locus_tag old_locus_tag gene Name start end strand product note type ID NCBI VSVS12_00001 VSVS12_00001 sthA sthA 2 706 + NAD(P)(+) transhydrogenase (Si-specific) Conversion of NADPH%2C generated by peripheral catabolic pathways%2C to NADH%2C which can enter the respiratory chain for energy generation%3B Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family%3B KEGG: vch:VC0151 NAD(P) transhydrogenase gene gene0 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00001 VSVS12_00002 VSVS12_00002 VSVS12_00002 776 2080 - DNA-damage-inducible protein Belongs to the multi antimicrobial extrusion (MATE) (TC 2. A. 66. 1) family gene gene1 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00002 VSVS12_00003 VSVS12_00003 VSVS12_00003 2157 2975 - hypothetical protein gene gene2 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00003 VSVS12_00004 VSVS12_00004 lexA lexA 3069 3689 - Repressor LexA Represses a number of genes involved in the response to DNA damage (SOS response)%2C including recA and lexA. In the presence of single-stranded DNA%2C RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA%2C leading to derepression of the SOS regulon and eventually DNA repair%3B Belongs to the peptidase S24 family%3B KEGG: hin:HI0749 repressor LexA gene gene3 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00004 VSVS12_00005 VSVS12_00005 dgkA dgkA 3775 4152 - Diacylglycerol kinase (ATP) Recycling of diacylglycerol produced during the turnover of membrane phospholipid%3B Belongs to the bacterial diacylglycerol kinase family%3B KEGG: vcy:IX92_00905 diacylglycerol kinase (ATP) gene gene4 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00005 VSVS12_00006 VSVS12_00006 plsB plsB 4338 6794 + Glycerol-3-phosphate 1-O-acyltransferase Belongs to the GPAT/DAPAT family%3B KEGG: vtu:IX91_14530 glycerol-3-phosphate O-acyltransferase gene gene5 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00006 VSVS12_00007 VSVS12_00007 ubiA ubiA 6925 7779 - 4-hydroxybenzoate polyprenyltransferase Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis%2C which is the condensation of the polyisoprenoid side chain with PHB%2C generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate%3B Belongs to the UbiA prenyltransferase family%3B KEGG: vfu:vfu_A00475 4-hydroxybenzoate polyprenyltransferase gene gene6 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00007 VSVS12_00008 VSVS12_00008 ubiC ubiC 7780 8319 - Chorismate lyase Removes the pyruvyl group from chorismate%2C with concomitant aromatization of the ring%2C to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway%3B Belongs to the UbiC family%3B KEGG: van:VAA_00456 chorismate--pyruvate lyase gene gene7 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00008 VSVS12_00009 VSVS12_00009 VSVS12_00009 8486 8896 + Flagellar protein FliL Controls the rotational direction of flagella during chemotaxis%3B Belongs to the FliL family gene gene8 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00009 VSVS12_00010 VSVS12_00010 VSVS12_00010 8970 9794 - Rhomboid protease GlpG Rhomboid-type serine protease that catalyzes intramembrane proteolysis%3B Belongs to the peptidase S54 family gene gene9 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00010 VSVS12_00011 VSVS12_00011 glpE glpE 9803 10123 - Thiosulfate sulfurtransferase Catalyzes%2C although with low efficiency%2C the sulfur transfer reaction from thiosulfate to cyanide%3B Belongs to the GlpE family%3B Contains 1 rhodanese domain%3B KEGG: eco:b3425 thiosulfate sulfurtransferase gene gene10 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00011 VSVS12_00012 VSVS12_00012 VSVS12_00012 10517 11374 - RNA polymerase sigma factor RpoH Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is involved in regulation of expression of heat shock genes%3B Belongs to the sigma-70 factor family. RpoH subfamily gene gene11 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00012 VSVS12_00013 VSVS12_00013 VSVS12_00013 11561 12523 - Cell division protein FtsX Part of the ABC transporter FtsEX involved in cellular division. Encoded in an operon consisting of genes ftsY%2C ftsE and ftsX%3B Belongs to the ABC-4 integral membrane protein family. FtsX subfamily gene gene12 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00013 VSVS12_00014 VSVS12_00014 VSVS12_00014 12513 13187 - Energy-coupling factor transporter ATP-binding protein EcfA1 ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates%3B Belongs to the ABC transporter superfamily. Energy- coupling factor EcfA family%3B Contains 1 ABC transporter domain gene gene13 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00014 VSVS12_00015 VSVS12_00015 VSVS12_00015 13214 14404 - Signal recognition particle receptor FtsY Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane%2C the hydrolysis of GTP by both Ffh and FtsY%2C and the dissociation of the SRP-FtsY complex into the individual components%3B Belongs to the GTP-binding SRP family. FtsY subfamily gene gene14 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00015 VSVS12_00016 VSVS12_00016 rsmD rsmD 14614 15213 + 16S rRNA (guanine(966)-N(2))-methyltransferase Specifically methylates the guanine in position 966 of 16S rRNA in the assembled 30S particle%3B Belongs to the methyltransferase superfamily. RsmD family%3B KEGG: vvu:VV1_1153 16S rRNA (guanine966-N2)-methyltransferase gene gene15 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00016 VSVS12_00017 VSVS12_00017 VSVS12_00017 15223 15489 + hypothetical protein gene gene16 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00017 VSVS12_00018 VSVS12_00018 VSVS12_00018 15601 16185 - UPF0056 inner membrane protein Belongs to the UPF0056 (MarC) family gene gene17 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00018 VSVS12_00019 VSVS12_00019 VSVS12_00019 16419 17627 + hypothetical protein gene gene18 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00019 VSVS12_00020 VSVS12_00020 VSVS12_00020 17637 17861 - hypothetical protein gene gene19 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00020 VSVS12_00021 VSVS12_00021 VSVS12_00021 17994 18617 - hypothetical protein gene gene20 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00021 VSVS12_00022 VSVS12_00022 VSVS12_00022 19567 19932 - hypothetical protein gene gene21 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00022 VSVS12_00023 VSVS12_00023 VSVS12_00023 20185 20514 + hypothetical protein gene gene22 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00023 VSVS12_00024 VSVS12_00024 VSVS12_00024 20531 21544 - hypothetical protein gene gene23 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00024 VSVS12_00025 VSVS12_00025 VSVS12_00025 21673 22890 - hypothetical protein gene gene24 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00025 VSVS12_00026 VSVS12_00026 draG draG 22957 23466 - ADP-ribosyl-[dinitrogen reductase] hydrolase KEGG: mex:Mext_4887 ADP-ribosyl-(dinitrogen reductase) hydrolase gene gene25 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00026 VSVS12_00027 VSVS12_00027 gapA gapA 23477 24478 - Glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) Involved in the glycolysis. Catalyzes the oxidative phosphorylation of glyceraldehyde 3-phosphate (G3P) to 1%2C3- bisphosphoglycerate (BPG) using the cofactor NAD. The first reaction step involves the formation of a hemiacetal intermediate between G3P and a cysteine residue%2C and this hemiacetal intermediate is then oxidized to a thioester%2C with concomitant reduction of NAD to NADH. The reduced NADH is then exchanged with the second NAD%2C and the thioester is attacked by a nucleophilic inorganic phosphate to produce BPG%3B Belongs to the glyceraldehyde-3-phosphate dehydrogenase family%3B KEGG: eco:b1779 glyceraldehyde 3-phosphate dehydrogenase gene gene26 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00027 VSVS12_00028 VSVS12_00028 VSVS12_00028 24499 24840 - Arsenical resistance operon repressor Transcriptional repressor for the ars operon. ArsR is a trans-acting regulatory protein which controls its own expression. The repressive effect of ArsR is alleviated by oxyions of +III oxidation state of arsenic%2C antimony%2C and bismuth%2C as well as arsenate (As(V)). Contains 1 HTH arsR-type DNA-binding domain gene gene27 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00028 VSVS12_00029 VSVS12_00029 VSVS12_00029 24950 26176 - uncharacterized protein Contains 1 EAL domain gene gene28 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00029 VSVS12_00030 VSVS12_00030 VSVS12_00030 26209 26826 - Leucine efflux protein Exporter of leucine%3B Belongs to the rht family gene gene29 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00030 VSVS12_00031 VSVS12_00031 pldB pldB 26911 27900 + Lysophospholipase KEGG: vpa:VP2974 lysophospholipase gene gene30 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00031 VSVS12_00032 VSVS12_00032 VSVS12_00032 28031 28858 + Putative phosphatase Belongs to the HAD-like hydrolase superfamily. Cof family gene gene31 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00032 VSVS12_00033 VSVS12_00033 VSVS12_00033 29057 30598 + hypothetical protein gene gene32 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00033 VSVS12_00034 VSVS12_00034 VSVS12_00034 30598 31227 + DTW domain-containing protein YfiP Belongs to the DTW family gene gene33 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00034 VSVS12_00035 VSVS12_00035 VSVS12_00035 31252 31965 - 5-amino-6-(5-phospho-D-ribitylamino)uracil phosphatase YigB Catalyzes the dephosphorylation of 5-amino-6-(5-phospho- D-ribitylamino)uracil%2C and thus could be involved in the riboflavin biosynthesis pathway (PubMed:24123841). Is also able to dephosphorylate flavin mononucleotide (FMN) and other phosphoric acid esters (PubMed:16990279) (PubMed:24123841). YigB is important for the formation of dormant persister cells (PubMed:18519731)%3B Belongs to the HAD-like hydrolase superfamily gene gene34 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00035 VSVS12_00036 VSVS12_00036 VSVS12_00036 32018 32938 - Tyrosine recombinase XerC Site-specific tyrosine recombinase%2C which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids%3B Belongs to the 'phage' integrase family. XerC subfamily gene gene35 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00036 VSVS12_00037 VSVS12_00037 VSVS12_00037 32910 33614 - uncharacterized protein gene gene36 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00037 VSVS12_00038 VSVS12_00038 dapF dapF 33629 34459 - Diaminopimelate epimerase Catalyzes the stereoinversion of LL-2%2C6- diaminoheptanedioate (L%2CL-DAP) to meso-diaminoheptanedioate (meso- DAP)%2C a precursor of L-lysine and an essential component of the bacterial peptidoglycan%3B Belongs to the diaminopimelate epimerase family%3B KEGG: vch:VC0126 diaminopimelate epimerase gene gene37 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00038 VSVS12_00039 VSVS12_00039 lysA lysA 34470 35723 - Diaminopimelate decarboxylase Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine%3B Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily%3B KEGG: vch:VC0125 diaminopimelate decarboxylase gene gene38 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00039 VSVS12_00040 VSVS12_00040 VSVS12_00040 35978 36292 + Protein CyaY Belongs to the frataxin family gene gene39 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00040 VSVS12_00041 VSVS12_00041 cyaA cyaA 36390 38918 - Adenylate cyclase Belongs to the adenylyl cyclase class-1 family%3B KEGG: vvu:VV1_1123 adenylate cyclase%2C class 1 gene gene40 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00041 VSVS12_00042 VSVS12_00042 hemC hemC 39267 40205 + Hydroxymethylbilane synthase Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps%3B Belongs to the HMBS family%3B KEGG: vvu:VV1_1122 hydroxymethylbilane synthase gene gene41 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00042 VSVS12_00043 VSVS12_00043 hemD hemD 40211 40945 + Uroporphyrinogen-III synthase Catalyzes cyclization of the linear tetrapyrrole%2C hydroxymethylbilane%2C to the macrocyclic uroporphyrinogen III%3B Belongs to the uroporphyrinogen-III synthase family%3B KEGG: dzc:W909_18870 uroporphyrinogen-III synthase gene gene42 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00043 VSVS12_00044 VSVS12_00044 hemX hemX 40956 42203 + Uroporphyrinogen-III C-methyltransferase KEGG: vpa:VP2990 uroporphyrin-III C-methyltransferase gene gene43 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00044 VSVS12_00045 VSVS12_00045 VSVS12_00045 42203 43381 + hypothetical protein Involved in a late step of protoheme IX synthesis%3B Contains 2 TPR repeats gene gene44 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00045 VSVS12_00046 VSVS12_00046 VSVS12_00046 43502 43834 + hypothetical protein gene gene45 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00046 VSVS12_00047 VSVS12_00047 VSVS12_00047 43955 44683 - Transposase InsF for insertion sequence IS3A Involved in the transposition of the insertion sequence IS3. Belongs to the transposase IS3/IS150/IS904 family%3B Contains 1 integrase catalytic domain gene gene46 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00047 VSVS12_00048 VSVS12_00048 VSVS12_00048 44782 45192 - hypothetical protein gene gene47 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00048 VSVS12_00049 VSVS12_00049 VSVS12_00049 45282 45358 - tRNA-Asp tRNA gene48 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00049 VSVS12_00050 VSVS12_00050 VSVS12_00050 45429 45544 - 5S ribosomal RNA rRNA gene49 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00050 VSVS12_00051 VSVS12_00051 VSVS12_00051 45635 48528 - 23S ribosomal RNA rRNA gene50 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00051 VSVS12_00052 VSVS12_00052 VSVS12_00052 48823 48898 - tRNA-Ala tRNA gene51 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00052 VSVS12_00053 VSVS12_00053 VSVS12_00053 48941 49017 - tRNA-Ile tRNA gene52 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00053 VSVS12_00054 VSVS12_00054 VSVS12_00054 49084 50630 - 16S ribosomal RNA rRNA gene53 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00054 VSVS12_00055 VSVS12_00055 VSVS12_00055 51007 51122 - 5S ribosomal RNA rRNA gene54 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00055 VSVS12_00056 VSVS12_00056 VSVS12_00056 51213 54106 - 23S ribosomal RNA rRNA gene55 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00056 VSVS12_00057 VSVS12_00057 VSVS12_00057 54401 54476 - tRNA-Ala tRNA gene56 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00057 VSVS12_00058 VSVS12_00058 VSVS12_00058 54519 54595 - tRNA-Ile tRNA gene57 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00058 VSVS12_00059 VSVS12_00059 VSVS12_00059 54662 56208 - 16S ribosomal RNA rRNA gene58 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00059 VSVS12_00060 VSVS12_00060 ubiB ubiB 56750 57463 - Aquacobalamin reductase Involved in bioluminescence. It is a good supplier of reduced flavin mononucleotide (FMNH2) to the bioluminescence reaction. Preferably uses riboflavin as an electron acceptor when NADPH is used as an electron donor. Belongs to the Fre/LuxG FAD/NAD(P) flavoprotein oxidoreductase family%3B Contains 1 FAD-binding FR-type domain%3B KEGG: vch:VC0312 aquacobalamin reductase / NAD(P)H-flavin reductase gene gene59 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00060 VSVS12_00061 VSVS12_00061 VSVS12_00061 57478 57747 - Ferredoxin--NAD(+) reductase Oxidizes toluene and xylenes to (methyl)benzyl alcohols. The enzyme has a broad specificity and also oxidizes (methyl)benzyl alcohols to (methyl)benzaldehydes and indole to indoxyl. Belongs to the bacterial ring-hydroxylating dioxygenase ferredoxin reductase family%3B Contains 1 2Fe-2S ferredoxin-type domain%3B Contains 1 FAD-binding FR-type domain%3B KEGG: ppf:Pput_2902 p-cymene monooxygenase electron transfer component gene gene60 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00061 VSVS12_00062 VSVS12_00062 ubiD ubiD 57747 59591 - 4-hydroxy-3-polyprenylbenzoate decarboxylase Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol%2C an intermediate step in ubiquinone biosynthesis%3B Belongs to the UbiD family%3B KEGG: ype:YPO3769 4-hydroxy-3-polyprenylbenzoate decarboxylase gene gene61 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00062 VSVS12_00063 VSVS12_00063 VSVS12_00063 59682 60680 - hypothetical protein gene gene62 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00063 VSVS12_00064 VSVS12_00064 VSVS12_00064 60783 62042 - Transcription termination factor Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA%2C activation of Rho's RNA-dependent ATPase activity%2C and release of the mRNA from the DNA template%3B Belongs to the Rho family gene gene63 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00064 VSVS12_00065 VSVS12_00065 VSVS12_00065 62246 62572 - Protein disulfide-isomerase A6 May function as a chaperone that inhibits aggregation of misfolded proteins. Plays a role in platelet aggregation and activation by agonists such as convulxin%2C collagen and thrombin%3B Belongs to the protein disulfide isomerase family%3B Contains 2 thioredoxin domains gene gene64 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00065 VSVS12_00066 VSVS12_00066 rhlB rhlB 62684 63985 + RNA helicase DEAD-box RNA helicase involved in RNA degradation. Has RNA-dependent ATPase activity and unwinds double-stranded RNA%3B Belongs to the DEAD box helicase family. RhlB subfamily%3B Contains 1 helicase ATP-binding domain%3B Contains 1 helicase C-terminal domain%3B KEGG: eco:b3780 ATP-dependent RNA helicase RhlB gene gene65 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00066 VSVS12_00067 VSVS12_00067 VSVS12_00067 63992 65482 + Exopolyphosphatase Conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the 'stringent response'%2C an adaptive process that allows bacteria to respond to amino acid starvation%2C resulting in the coordinated regulation of numerous cellular activities%3B Belongs to the GppA/Ppx family. GppA subfamily%3B KEGG: aex:Astex_2636 exopolyphosphatase / guanosine-5'-triphosphate%2C3'-diphosphate pyrophosphatase gene gene66 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00067 VSVS12_00068 VSVS12_00068 VSVS12_00068 65593 66273 - Inner membrane protein YhhQ To H. influenzae HI_0862 gene gene67 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00068 VSVS12_00069 VSVS12_00069 VSVS12_00069 66484 66819 - hypothetical protein gene gene68 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00069 VSVS12_00070 VSVS12_00070 recQ recQ 66812 68650 - DNA helicase Involved in the RecF recombination pathwa%3B its gene expression is under the regulation of the SOS system. It is a DNA helicase%3B Belongs to the helicase family. RecQ subfamily%3B Contains 1 helicase ATP-binding domain%3B Contains 1 helicase C-terminal domain%3B Contains 1 HRDC domain%3B KEGG: vvu:VV1_0943 ATP-dependent DNA helicase RecQ gene gene69 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00070 VSVS12_00071 VSVS12_00071 VSVS12_00071 68797 69711 + Protein RarD Belongs to the EamA transporter family%3B Contains 1 EamA domain gene gene70 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00071 VSVS12_00072 VSVS12_00072 VSVS12_00072 69778 70575 + putative HTH-type transcriptional regulator YbfI Contains 1 HTH araC/xylS-type DNA-binding domain gene gene71 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00072 VSVS12_00073 VSVS12_00073 VSVS12_00073 70647 71300 + Threonine efflux protein Conducts the efflux of threonine%3B Belongs to the rht family gene gene72 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00073 VSVS12_00074 VSVS12_00074 uvrD uvrD 72266 74440 - DNA helicase Has both ATPase and helicase activities. Unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present. Involved in the post-incision events of nucleotide excision repair and methyl-directed mismatch repair. Belongs to the helicase family. UvrD subfamily%3B Contains 1 uvrD-like helicase ATP-binding domain%3B Contains 1 uvrD-like helicase C-terminal domain%3B KEGG: vch:VC0190 DNA helicase II / ATP-dependent DNA helicase PcrA gene gene73 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00074 VSVS12_00075 VSVS12_00075 VSVS12_00075 74697 74957 + hypothetical protein gene gene74 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00075 VSVS12_00076 VSVS12_00076 VSVS12_00076 75053 75925 + UPF0276 protein Belongs to the UPF0276 family gene gene75 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00076 VSVS12_00077 VSVS12_00077 VSVS12_00077 75922 76704 + hypothetical protein gene gene76 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00077 VSVS12_00078 VSVS12_00078 VSVS12_00078 76714 77169 + hypothetical protein gene gene77 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00078 VSVS12_00079 VSVS12_00079 prlC prlC 77282 79324 - Oligopeptidase A May play a specific role in the degradation of signal peptides after they are released from precursor forms of secreted proteins. Can cleave N-acetyl-L-Ala(4) (By similarity)%3B Belongs to the peptidase M3 family%3B KEGG: pmu:PM0680 oligopeptidase A gene gene78 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00079 VSVS12_00080 VSVS12_00080 rlmJ rlmJ 79587 80426 + 23S rRNA (adenine(2030)-N(6))-methyltransferase Specifically methylates the adenine in position 2030 of 23S rRNA. Nascent 23S rRNA seems to be the natural substrate. Appears to be not necessary for ribosome assembly. Seems to be required for the utilization of extracellular DNA as the sole source of carbon and energy%3B Belongs to the RlmJ family%3B KEGG: eco:b3499 23S rRNA (adenine2030-N6)-methyltransferase gene gene79 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00080 VSVS12_00081 VSVS12_00081 VSVS12_00081 80680 82035 + Glutathione-disulfide reductase Maintains high levels of reduced glutathione in the cytosol%3B Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family%3B KEGG: vch:VC0186 glutathione reductase (NADPH) gene gene80 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00081 VSVS12_00082 VSVS12_00082 VSVS12_00082 82372 84627 + hypothetical protein gene gene81 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00082 VSVS12_00083 VSVS12_00083 VSVS12_00083 84694 85323 - uncharacterized protein To H. influenzae HI_0575 gene gene82 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00083 VSVS12_00084 VSVS12_00084 VSVS12_00084 85528 86763 + C4-dicarboxylate transport protein Responsible for the transport of dicarboxylates such as succinate%2C fumarate%2C and malate from the periplasm across the membrane%3B Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2. A. 23) family gene gene83 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00084 VSVS12_00085 VSVS12_00085 metC metC 86775 87962 + Cystathionine beta-lyase Belongs to the trans-sulfuration enzymes family%3B KEGG: spe:Spro_4212 cystathionine beta-lyase gene gene84 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00085 VSVS12_00086 VSVS12_00086 ridA ridA 88009 88383 + 2-iminobutanoate/2-iminopropanoate deaminase Belongs to the RutC family%3B KEGG: cml:BN424_362 2-iminobutanoate/2-iminopropanoate deaminase gene gene85 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00086 VSVS12_00087 VSVS12_00087 VSVS12_00087 88676 90622 + Methyl-accepting chemotaxis protein PctC Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment%2C transduce a signal from the outside to the inside of the cell%2C and facilitate sensory adaptation through the variation of the level of methylation. Responds to L-His%2C L-Pro and GABA. Also involved in repellent responses to trichloroethylene (TCE)%2C chloroform and methylthiocyanate%3B Contains 1 cache domain%3B Contains 1 HAMP domain%3B Contains 1 methyl-accepting transducer domain gene gene86 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00087 VSVS12_00088 VSVS12_00088 VSVS12_00088 90836 92122 + Non-specific serine/threonine protein kinase Plays a role in conventional modes of cytokinesis in meristems and during male gametogenesis but also acts in nonconventional modes of cytokinesis (cellularization) during female gametogenesis. Constitutes a signaling module in association with Kinesin-12 members that is required to support phragmoplast expansion and cell-plate growth in plant cells%3B Belongs to the protein kinase superfamily. Ser/Thr protein kinase family%3B Contains 6 ARM repeats%3B Contains 1 protein kinase domain%3B KEGG: vsa:VSAL_I0118 serine/threonine protein kinase%2C bacterial gene gene87 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00088 VSVS12_00089 VSVS12_00089 VSVS12_00089 92143 92649 + hypothetical protein gene gene88 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00089 VSVS12_00090 VSVS12_00090 VSVS12_00090 92689 93897 + hypothetical protein gene gene89 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00090 VSVS12_00091 VSVS12_00091 VSVS12_00091 93925 94941 + hypothetical protein gene gene90 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00091 VSVS12_00092 VSVS12_00092 VSVS12_00092 94941 95510 + hypothetical protein gene gene91 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00092 VSVS12_00093 VSVS12_00093 VSVS12_00093 95517 97097 + hypothetical protein gene gene92 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00093 VSVS12_00094 VSVS12_00094 VSVS12_00094 97540 100647 + hypothetical protein gene gene93 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00094 VSVS12_00095 VSVS12_00095 VSVS12_00095 100717 101664 - hypothetical protein gene gene94 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00095 VSVS12_00096 VSVS12_00096 eptA eptA 101920 103590 - Phosphoethanolamine transferase EptA Catalyzes the addition of a phosphoethanolamine moiety to the lipid A. The phosphoethanolamine modification is required for resistance to polymyxin (By similarity)%3B Belongs to the phosphoethanolamine transferase family. EptA subfamily%3B KEGG: van:VAA_03291 lipid A ethanolaminephosphotransferase%3B Transferases for other substituted phosphate groups gene gene95 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00096 VSVS12_00097 VSVS12_00097 VSVS12_00097 103587 103952 - Diacylglycerol kinase (ATP) Recycling of diacylglycerol produced during the turnover of membrane phospholipid%3B Belongs to the bacterial diacylglycerol kinase family%3B KEGG: spoi:IMCC21906_00961 diacylglycerol kinase (ATP) gene gene96 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00097 VSVS12_00098 VSVS12_00098 VSVS12_00098 104153 105109 - Dipeptide transport system permease protein Part of the binding-protein-dependent transport system for dipeptide%3B probably responsible for the translocation of the substrate across the membrane%3B Belongs to the binding-protein-dependent transport system permease family. OppBC subfamily%3B Contains 1 ABC transmembrane type-1 domain gene gene97 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00098 VSVS12_00099 VSVS12_00099 VSVS12_00099 105112 106089 - putative D%2CD-dipeptide transport system permease protein DdpB Part of the ABC transporter complex DdpABCDF%2C which is probably involved in D%2CD-dipeptide transport. Probably responsible for the translocation of the substrate across the membrane. Belongs to the binding-protein-dependent transport system permease family. OppBC subfamily%3B Contains 1 ABC transmembrane type-1 domain gene gene98 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00099 VSVS12_00100 VSVS12_00100 VSVS12_00100 106292 107845 - Putative peptide-binding periplasmic protein Probably part of an ABC transporter complex that could be involved in peptide import%3B Belongs to the bacterial solute-binding protein 5 family gene gene99 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00100 VSVS12_00101 VSVS12_00101 VSVS12_00101 107910 109652 - Dipeptide transport ATP-binding protein DppD Part of the binding-protein-dependent transport system for dipeptides. Probably responsible for energy coupling to the transport system (By similarity)%3B Belongs to the ABC transporter superfamily%3B Contains 1 ABC transporter domain gene gene100 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00101 VSVS12_00102 VSVS12_00102 VSVS12_00102 110405 110481 - tRNA-Pro tRNA gene101 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00102 VSVS12_00103 VSVS12_00103 VSVS12_00103 110535 110610 - tRNA-His tRNA gene102 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00103 VSVS12_00104 VSVS12_00104 VSVS12_00104 110655 110731 - tRNA-Pro tRNA gene103 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00104 VSVS12_00105 VSVS12_00105 VSVS12_00105 110787 110862 - tRNA-His tRNA gene104 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00105 VSVS12_00106 VSVS12_00106 VSVS12_00106 110897 110973 - tRNA-Arg tRNA gene105 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00106 VSVS12_00107 VSVS12_00107 coxD coxD 111269 111676 + Cytochrome-c oxidase KEGG: noc:Noc_1247 cytochrome c oxidase subunit IV gene gene106 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00107 VSVS12_00108 VSVS12_00108 VSVS12_00108 111805 113823 - DNA helicase Rep helicase is a single-stranded DNA-dependent ATPase involved in DNA replicatio%3B it can initiate unwinding at a nick in the DNA. It binds to the single-stranded DNA and acts in a progressive fashion along the DNA in the 3' to 5' direction%3B Belongs to the helicase family. UvrD subfamily%3B Contains 1 uvrD-like helicase ATP-binding domain%3B Contains 1 uvrD-like helicase C-terminal domain%3B KEGG: eco:b3778 ATP-dependent DNA helicase Rep gene gene107 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00108 VSVS12_00109 VSVS12_00109 VSVS12_00109 114037 114618 + putative HTH-type transcriptional regulator Contains 1 HTH tetR-type DNA-binding domain gene gene108 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00109 VSVS12_00110 VSVS12_00110 VSVS12_00110 114658 115743 + uncharacterized protein Belongs to the membrane fusion protein (MFP) (TC 8. A. 1) family gene gene109 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00110 VSVS12_00111 VSVS12_00111 VSVS12_00111 115755 118880 + putative transporter Could be a drug efflux pump%3B Belongs to the resistance-nodulation-cell division (RND) (TC 2. A. 6) family gene gene110 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00111 VSVS12_00112 VSVS12_00112 VSVS12_00112 119045 119296 + uncharacterized protein gene gene111 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00112 VSVS12_00113 VSVS12_00113 ilvC ilvC 119501 120985 - Ketol-acid reductoisomerase (NADP(+)) Belongs to the ketol-acid reductoisomerase family%3B KEGG: eco:b3774 ketol-acid reductoisomerase gene gene112 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00113 VSVS12_00114 VSVS12_00114 VSVS12_00114 121131 122021 + putative HTH-type transcriptional regulator in ibpB-leuC intergenic region Contains 1 HTH lysR-type DNA-binding domain gene gene113 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00114 VSVS12_00115 VSVS12_00115 hemN hemN 122074 123462 - Coproporphyrinogen dehydrogenase Involved in the heme biosynthesis. Catalyzes the anaerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX. It can use NAD or NADP%2C but NAD is preferred%3B Belongs to the anaerobic coproporphyrinogen-III oxidase family%3B KEGG: vcy:IX92_00390 oxygen-independent coproporphyrinogen III oxidase gene gene114 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00115 VSVS12_00116 VSVS12_00116 VSVS12_00116 123651 124139 - uncharacterized protein gene gene115 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00116 VSVS12_00117 VSVS12_00117 VSVS12_00117 124148 124708 - Der GTPase-activating protein YihI A GTPase-activating protein (GAP) that modifies Der/EngA GTPase function. May play a role in ribosome biogenesis%3B Belongs to the YihI family gene gene116 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00117 VSVS12_00118 VSVS12_00118 glgP glgP 124708 125346 - Glycogen phosphorylase KEGG: dfa:DFA_02214 starch phosphorylase gene gene117 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00118 VSVS12_00119 VSVS12_00119 VSVS12_00119 126156 126773 - Cytochrome c4 KEGG: bxe:Bxe_A0346 null%3B Oxidoreductases gene gene118 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00119 VSVS12_00120 VSVS12_00120 VSVS12_00120 126922 127587 + putative GTP-binding protein EngB Necessary for normal cell division and for the maintenance of normal septation%3B Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin- like GTPase superfamily. EngB GTPase family%3B Contains 1 EngB-type G (guanine nucleotide-binding) domain gene gene119 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00120 VSVS12_00121 VSVS12_00121 dpo1 dpo1 128224 131025 - DNA-directed DNA polymerase In addition to polymerase activity%2C this DNA polymerase exhibits 3' to 5' and 5' to 3' exonuclease activity. It is able to utilize nicked circular duplex DNA as a template and can unwind the parental DNA strand from its template. Belongs to the DNA polymerase type-A family%3B Contains 1 3'-5' exonuclease domain%3B Contains 1 5'-3' exonuclease domain%3B KEGG: vsp:VS_0108 DNA polymerase I gene gene120 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00121 VSVS12_00122 VSVS12_00122 hemB hemB 131778 132821 - Porphobilinogen synthase Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit%2C each at a distinct site%2C and catalyzes their condensation to form porphobilinogen (By similarity)%3B Belongs to the ALAD family%3B KEGG: vch:VC0105 porphobilinogen synthase gene gene121 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00122 VSVS12_00123 VSVS12_00123 tatD tatD 132984 133745 + 3'-5' ssDNA/RNA exonuclease TatD 3'-5' exonuclease that prefers single-stranded DNA and RNA. May play a role in the H(2)O(2)-induced DNA damage repair%3B Belongs to the TatD-type hydrolase family. TatD subfamily%3B KEGG: vch:VC0103 TatD DNase family protein%3B Endodeoxyribonucleases producing 5'-phosphomonoesters gene gene122 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00123 VSVS12_00124 VSVS12_00124 VSVS12_00124 133831 134583 - Sec-independent protein translocase protein Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB%2C TatC is part of a receptor directly interacting with Tat signal peptides%3B Belongs to the TatC family gene gene123 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00124 VSVS12_00125 VSVS12_00125 VSVS12_00125 134648 135028 - Sec-independent protein translocase protein TatB Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC%2C TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation%3B Belongs to the TatB family gene gene124 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00125 VSVS12_00126 VSVS12_00126 VSVS12_00126 135032 135274 - Sec-independent protein translocase protein TatA Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system%3B Belongs to the TatA/E family gene gene125 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00126 VSVS12_00127 VSVS12_00127 VSVS12_00127 135325 136959 - putative protein kinase UbiB Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis%3B Belongs to the ABC1 family. UbiB subfamily%3B Contains 1 protein kinase domain gene gene126 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00127 VSVS12_00128 VSVS12_00128 VSVS12_00128 136956 137561 - Ubiquinone biosynthesis protein UbiJ Involved in ubiquinone (coenzyme Q) biosynthesis under aerobic conditions%3B Belongs to the UbiJ family gene gene127 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00128 VSVS12_00129 VSVS12_00129 ubiE ubiE 137570 138352 - Demethylmenaquinone methyltransferase Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1%2C4-benzoquinol (DDMQH2) to 2- polyprenyl-3-methyl-6-methoxy-1%2C4-benzoquinol (DMQH2)%3B Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family%3B KEGG: vfu:vfu_A00410 demethylmenaquinone methyltransferase / 2-methoxy-6-polyprenyl-1%2C4-benzoquinol methylase gene gene128 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00129 VSVS12_00130 VSVS12_00130 VSVS12_00130 138506 140056 - DNA recombination protein RmuC like protein Involved in DNA recombination%3B Belongs to the RmuC family gene gene129 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00130 VSVS12_00131 VSVS12_00131 VSVS12_00131 140241 141146 + hypothetical protein gene gene130 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00131 VSVS12_00132 VSVS12_00132 VSVS12_00132 141247 141858 - 2-dehydro-3-deoxy-phosphogluconate aldolase Belongs to the KHG/KDPG aldolase family%3B KEGG: vvu:VV1_1102 2-dehydro-3-deoxyphosphogluconate aldolase / (4S)-4-hydroxy-2-oxoglutarate aldolase gene gene131 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00132 VSVS12_00133 VSVS12_00133 VSVS12_00133 141868 143244 - Gluconate permease Belongs to the GntP permease family gene gene132 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00133 VSVS12_00134 VSVS12_00134 gntK gntK 143398 143919 + Gluconokinase Belongs to the gluconokinase GntK/GntV family%3B KEGG: vch:VC0287 gluconokinase gene gene133 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00134 VSVS12_00135 VSVS12_00135 VSVS12_00135 143916 145712 + Phosphogluconate dehydratase Belongs to the IlvD/Edd family%3B KEGG: vpa:VP0062 phosphogluconate dehydratase gene gene134 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00135 VSVS12_00136 VSVS12_00136 VSVS12_00136 145805 146812 - HTH-type transcriptional regulator IdnR Idn operon regulator. May repress gntKU and gntT genes when growing on L-idonate%3B Contains 1 HTH lacI-type DNA-binding domain gene gene135 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00136 VSVS12_00137 VSVS12_00137 VSVS12_00137 147178 147924 + Protein cII gene gene136 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00137 VSVS12_00138 VSVS12_00138 VSVS12_00138 147986 149113 - hypothetical protein gene gene137 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00138 VSVS12_00139 VSVS12_00139 VSVS12_00139 149115 149612 - hypothetical protein gene gene138 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00139 VSVS12_00140 VSVS12_00140 VSVS12_00140 149609 150139 - hypothetical protein gene gene139 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00140 VSVS12_00141 VSVS12_00141 VSVS12_00141 150455 151684 - hypothetical protein gene gene140 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00141 VSVS12_00142 VSVS12_00142 VSVS12_00142 151819 153423 - hypothetical protein gene gene141 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00142 VSVS12_00143 VSVS12_00143 VSVS12_00143 153455 154879 - Transposon Tn7 transposition protein TnsC gene gene142 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00143 VSVS12_00144 VSVS12_00144 VSVS12_00144 154876 157008 - Transposon Tn7 transposition protein TnsB Sequence-specific%2C DNA-binding protein required for Tn7 transposition. Recognizes sequences necessary for recombination at both left and right ends of Tn7 and%2C together with TnsA%2C forms the transposase. TnsB executes the 5'-DNA strand breakage and joining reactions%3B Contains 1 integrase catalytic domain gene gene143 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00144 VSVS12_00145 VSVS12_00145 VSVS12_00145 156995 157822 - Transposon Tn7 transposition protein TnsA Required for Tn7 transposition. Forms the transposase%2C together with TnsB. TnsA executes the 5'-DNA strand breakage reaction. TnsABC and TnsD promote high-frequency insertion of Tn7 into a specific target site known as ATT-Tn7 whereas TnsABC and TnsD promote low-frequency insertion into many different sites gene gene144 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00145 VSVS12_00146 VSVS12_00146 VSVS12_00146 157955 159142 - uncharacterized protein To E. coli YhiN gene gene145 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00146 VSVS12_00147 VSVS12_00147 VSVS12_00147 159283 159606 - Universal stress protein B like protein Belongs to the universal stress protein B family gene gene146 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00147 VSVS12_00148 VSVS12_00148 VSVS12_00148 159679 160206 - putative bacterial non-heme ferritin Iron-storage protein%3B Belongs to the ferritin family. Prokaryotic subfamily%3B Contains 1 ferritin-like diiron domain gene gene147 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00148 VSVS12_00149 VSVS12_00149 VSVS12_00149 160360 160785 + Universal stress protein Required for resistance to DNA-damaging agents%3B Belongs to the universal stress protein A family gene gene148 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00149 VSVS12_00150 VSVS12_00150 VSVS12_00150 160845 161729 + putative membrane protein Contains 2 EamA domains gene gene149 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00150 VSVS12_00151 VSVS12_00151 rsmJ rsmJ 161795 162574 - 16S rRNA (guanine(1516)-N(2))-methyltransferase Specifically methylates the guanosine in position 1516 of 16S rRNA%3B Belongs to the methyltransferase superfamily. RsmJ family%3B KEGG: psi:S70_09940 16S rRNA (guanine1516-N2)-methyltransferase gene gene150 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00151 VSVS12_00152 VSVS12_00152 pleD pleD 162634 165810 - Diguanylate cyclase Involves in the regulation of cellulose production%3B Contains 1 GGDEF domain%3B KEGG: tig:THII_0061 two-component system%2C cell cycle response regulator gene gene151 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00152 VSVS12_00153 VSVS12_00153 VSVS12_00153 165916 166380 + putative HTH-type transcriptional regulator Contains 1 HTH asnC-type DNA-binding domain gene gene152 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00153 VSVS12_00154 VSVS12_00154 VSVS12_00154 166452 166736 - hypothetical protein gene gene153 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00154 VSVS12_00155 VSVS12_00155 VSVS12_00155 166920 168074 - Multidrug resistance protein MdtL Belongs to the major facilitator superfamily. DHA1 family. MdtL (TC 2. A. 1. 2. 22) subfamily gene gene154 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00155 VSVS12_00156 VSVS12_00156 VSVS12_00156 168215 169156 + HTH-type transcriptional regulator SyrM Acts in trans to stimulate nod gene expression%3B Contains 1 HTH lysR-type DNA-binding domain gene gene155 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00156 VSVS12_00157 VSVS12_00157 pepP pepP 169310 171097 + Xaa-Pro aminopeptidase Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides%3B Belongs to the peptidase M24B family%3B KEGG: vtu:IX91_15215 Xaa-Pro aminopeptidase gene gene156 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00157 VSVS12_00158 VSVS12_00158 thiH thiH 171226 172338 - 2-iminoacetate synthase Catalyzes the radical-mediated cleavage of tyrosine to 2-iminoacetate and 4-cresol%3B Belongs to the radical SAM superfamily. ThiH family%3B KEGG: vvu:VV1_0959 2-iminoacetate synthase gene gene157 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00158 VSVS12_00159 VSVS12_00159 thiG thiG 172348 173112 - Thiazole synthase Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro%2C sulfur can be provided by H(2)S%3B Belongs to the ThiG family%3B KEGG: senc:SEET0819_04595 thiazole synthase gene gene158 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00159 VSVS12_00160 VSVS12_00160 VSVS12_00160 173115 173324 - Sulfur carrier protein Is the sulfur donor in the synthesis of the thiazole phosphate moiety of thiamine phosphate%3B Belongs to the sulfur carrier protein ThiS family gene gene159 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00160 VSVS12_00161 VSVS12_00161 thiF thiF 173321 174097 - Sulfur carrier protein ThiS adenylyltransferase Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys)%2C tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers URM1 and MOCS2A. Its N-terminus first activates URM1 and MOCS2A as acyl-adenylates (-COAMP)%2C then the persulfide sulfur on the catalytic cysteine is transferred to URM1 and MOCS2A to form thiocarboxylation (-COSH) of their C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards URM1 and MOCS2A. Subsequently%2C a transient disulfide bond is formed. Does not use thiosulfate as sulfur dono%3B NFS1 probably acting as a sulfur donor for thiocarboxylation reactions%3B In the N-terminal sectio%3B belongs to the HesA/MoeB/ThiF family. UBA4 subfamily%3B Contains 1 rhodanese domain%3B KEGG: vch:VC0063 sulfur carrier protein ThiS adenylyltransferase gene gene160 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00161 VSVS12_00162 VSVS12_00162 thiE thiE 174087 175346 - Thiamine phosphate synthase Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP)%3B Belongs to the thiamine-phosphate synthase family%3B KEGG: vha:VIBHAR_00365 thiamine-phosphate pyrophosphorylase gene gene161 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00162 VSVS12_00163 VSVS12_00163 thiC thiC 175349 177286 - Phosphomethylpyrimidine synthase Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction%3B Belongs to the ThiC family%3B KEGG: vpa:VP3027 phosphomethylpyrimidine synthase gene gene162 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00163 VSVS12_00164 VSVS12_00164 VSVS12_00164 177584 177973 - Putative fluoride ion transporter CrcB Important for reducing fluoride concentration in the cell%2C thus reducing its toxicity%3B Belongs to the CrcB (TC 9. B. 71) family gene gene163 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00164 VSVS12_00165 VSVS12_00165 VSVS12_00165 178623 178699 - tRNA-Trp tRNA gene164 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00165 VSVS12_00166 VSVS12_00166 VSVS12_00166 178765 178841 - tRNA-Asp tRNA gene165 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00166 VSVS12_00167 VSVS12_00167 VSVS12_00167 178912 179027 - 5S ribosomal RNA rRNA gene166 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00167 VSVS12_00168 VSVS12_00168 VSVS12_00168 179118 182011 - 23S ribosomal RNA rRNA gene167 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00168 VSVS12_00169 VSVS12_00169 VSVS12_00169 182290 182365 - tRNA-Val tRNA gene168 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00169 VSVS12_00170 VSVS12_00170 VSVS12_00170 182403 182478 - tRNA-Ala tRNA gene169 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00170 VSVS12_00171 VSVS12_00171 VSVS12_00171 182489 182564 - tRNA-Lys tRNA gene170 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00171 VSVS12_00172 VSVS12_00172 VSVS12_00172 182569 182644 - tRNA-Glu tRNA gene171 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00172 VSVS12_00173 VSVS12_00173 VSVS12_00173 182738 184284 - 16S ribosomal RNA rRNA gene172 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00173 VSVS12_00174 VSVS12_00174 VSVS12_00174 184661 184776 - 5S ribosomal RNA rRNA gene173 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00174 VSVS12_00175 VSVS12_00175 VSVS12_00175 184869 187762 - 23S ribosomal RNA rRNA gene174 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00175 VSVS12_00176 VSVS12_00176 VSVS12_00176 188059 189605 - 16S ribosomal RNA rRNA gene175 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00176 VSVS12_00177 VSVS12_00177 hemG hemG 190117 190644 - Protoporphyrinogen IX dehydrogenase (menaquinone) Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX using menaquinone as electron acceptor%3B Contains 1 flavodoxin-like domain%3B KEGG: vvu:VV1_0978 menaquinone-dependent protoporphyrinogen oxidase gene gene176 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00177 VSVS12_00178 VSVS12_00178 VSVS12_00178 190654 192111 - Trk system potassium uptake protein TrkH Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA and requires TrkE for transport activity. Selective for permeation of potassium ion and rubidium ion over smaller ions such as natrium or litium%3B Belongs to the TrkH potassium transport family gene gene177 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00178 VSVS12_00179 VSVS12_00179 pepQ pepQ 192150 192773 - Xaa-Pro dipeptidase Belongs to the IMPACT family%3B KEGG: hpa:HPAG1_1428 Xaa-Pro dipeptidase gene gene178 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00179 VSVS12_00180 VSVS12_00180 fadB fadB 192975 195146 + 3-hydroxyacyl-CoA dehydrogenase Involved in the aerobic and anaerobic degradation of long-chain fatty acids via beta-oxidation cycle. Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA. It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate%3B In the N-terminal sectio%3B belongs to the enoyl-CoA hydratase/isomerase family%3B In the C-terminal sectio%3B belongs to the 3- hydroxyacyl-CoA dehydrogenase family%3B KEGG: vch:VC2758 3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase / 3-hydroxybutyryl-CoA epimerase / enoyl-CoA isomerase gene gene179 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00180 VSVS12_00181 VSVS12_00181 fadA fadA 195159 196334 + Acetyl-CoA C-acyltransferase Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed%3B Belongs to the thiolase family%3B KEGG: vpa:VP0029 acetyl-CoA acyltransferase gene gene180 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00181 VSVS12_00182 VSVS12_00182 VSVS12_00182 196381 197262 - putative HTH-type transcriptional regulator Contains 1 HTH lysR-type DNA-binding domain gene gene181 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00182 VSVS12_00183 VSVS12_00183 VSVS12_00183 197476 198681 + Putative multidrug resistance protein MdtD Belongs to the major facilitator superfamily. TCR/Tet family gene gene182 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00183 VSVS12_00184 VSVS12_00184 glmU glmU 198769 200130 - UDP-N-acetylglucosamine diphosphorylase Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P)%2C which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate)%2C a reaction catalyzed by the N-terminal domain%3B In the N-terminal sectio%3B belongs to the N- acetylglucosamine-1-phosphate uridyltransferase family%3B In the C-terminal sectio%3B belongs to the transferase hexapeptide repeat family%3B KEGG: bpn:BPEN_010 bifunctional UDP-N-acetylglucosamine pyrophosphorylase / Glucosamine-1-phosphate N-acetyltransferase gene gene183 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00184 VSVS12_00185 VSVS12_00185 VSVS12_00185 200284 200706 - ATP synthase epsilon chain Produces ATP from ADP in the presence of a proton gradient across the membrane%3B Belongs to the ATPase epsilon chain family gene gene184 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00185 VSVS12_00186 VSVS12_00186 atpD atpD 200725 202128 - H(+)-transporting two-sector ATPase Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits%3B Belongs to the ATPase alpha/beta chains family%3B KEGG: eco:b3732 F-type H+-transporting ATPase subunit beta gene gene185 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00186 VSVS12_00187 VSVS12_00187 VSVS12_00187 202164 203030 - ATP synthase gamma chain Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex%3B Belongs to the ATPase gamma chain family gene gene186 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00187 VSVS12_00188 VSVS12_00188 atpA atpA 203073 204614 - H(+)-transporting two-sector ATPase Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit%3B Belongs to the ATPase alpha/beta chains family%3B KEGG: eco:b3734 F-type H+-transporting ATPase subunit alpha gene gene187 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00188 VSVS12_00189 VSVS12_00189 VSVS12_00189 204628 205161 - ATP synthase subunit delta F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains%2C F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel%2C linked together by a central stalk and a peripheral stalk. During catalysis%2C ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation%3B This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction%3B Belongs to the ATPase delta chain family gene gene188 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00189 VSVS12_00190 VSVS12_00190 VSVS12_00190 205176 205646 - ATP synthase subunit b F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains%2C F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel%2C linked together by a central stalk and a peripheral stalk. During catalysis%2C ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation%3B Component of the F(0) channel%2C it forms part of the peripheral stalk%2C linking F(1) to F(0)%3B Belongs to the ATPase B chain family gene gene189 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00190 VSVS12_00191 VSVS12_00191 VSVS12_00191 205703 205960 - ATP synthase subunit F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains%2C F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel%2C linked together by a central stalk and a peripheral stalk. During catalysis%2C ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation%3B Key component of the F(0) channe%3B it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits%3B Belongs to the ATPase C chain family gene gene190 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00191 VSVS12_00192 VSVS12_00192 VSVS12_00192 206018 206830 - ATP synthase subunit a Key component of the proton channe%3B it plays a direct role in the translocation of protons across the membrane%3B Belongs to the ATPase A chain family gene gene191 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00192 VSVS12_00193 VSVS12_00193 VSVS12_00193 206839 207228 - ATP synthase protein A possible function for this protein is to guide the assembly of the membrane sector of the ATPase enzyme complex. Belongs to the bacterial AtpI family gene gene192 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00193 VSVS12_00194 VSVS12_00194 VSVS12_00194 207418 208299 - putative chromosome-partitioning protein ParB Involved in chromosome partition. Localize to both poles of the predivisional cell following completion of DNA replication. Binds to the DNA origin of replication (By similarity)%3B Belongs to the ParB family gene gene193 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00194 VSVS12_00195 VSVS12_00195 VSVS12_00195 208328 209101 - Sporulation initiation inhibitor protein Soj Inhibits the initiation of sporulation%2C Spo0J antagonizes this inhibition. Soj ultimately inhibits the activation (phosphorylation) of Spo0A. It is not required for chromosome partitioning (By similarity)%3B Belongs to the ParA family gene gene194 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00195 VSVS12_00196 VSVS12_00196 gidB gidB 209116 209748 - 16S rRNA (guanine(527)-N(7))-methyltransferase Specifically methylates the N7 position of guanine in position 527 of 16S rRNA%3B Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family%3B KEGG: vej:VEJY3_15500 16S rRNA (guanine527-N7)-methyltransferase gene gene195 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00196 VSVS12_00197 VSVS12_00197 VSVS12_00197 209748 211643 - tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs%2C forming tRNA-cmnm(5)s(2)U34%3B Belongs to the MnmG family gene gene196 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00197 VSVS12_00198 VSVS12_00198 VSVS12_00198 212115 212549 - Protein MioC like protein Probable electron transporter required for biotin synthase activity%3B Belongs to the flavodoxin family. MioC subfamily%3B Contains 1 flavodoxin-like domain gene gene197 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00198 VSVS12_00199 VSVS12_00199 mnmE mnmE 212635 213996 - tRNA modification GTPase MnmE Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs%2C forming tRNA- cmnm(5)s(2)U34%3B Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin- like GTPase superfamily. TrmE GTPase family%3B Contains 1 TrmE-type G (guanine nucleotide-binding) domain%3B KEGG: sml:Smlt4691 tRNA modification GTPase%3B Acting on acid anhydrides gene gene198 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00199 VSVS12_00200 VSVS12_00200 VSVS12_00200 214115 215734 - Membrane protein insertase YidC Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex%2C as well as at least some lipoproteins. Aids folding of multispanning membrane proteins%3B Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily gene gene199 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00200 VSVS12_00201 VSVS12_00201 VSVS12_00201 215737 215994 - Putative membrane protein insertion efficiency factor Could be involved in insertion of integral membrane proteins into the membrane%3B Belongs to the UPF0161 family gene gene200 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00201 VSVS12_00202 VSVS12_00202 rnpA rnpA 215961 216284 - Ribonuclease P RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4. 5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme%3B Belongs to the RnpA family%3B KEGG: bab:bbp014 ribonuclease P protein component gene gene201 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00202 VSVS12_00203 VSVS12_00203 VSVS12_00203 216331 216465 - 50S ribosomal protein L34 Belongs to the ribosomal protein L34P family gene gene202 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00203 VSVS12_00204 VSVS12_00204 VSVS12_00204 216693 217430 - Hemin import ATP-binding protein HmuV Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system%3B Belongs to the ABC transporter superfamily. Heme (hemin) importer (TC 3. A. 1. 14. 5) family%3B Contains 1 ABC transporter domain gene gene203 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00204 VSVS12_00205 VSVS12_00205 VSVS12_00205 217427 218098 - putative amino-acid ABC transporter permease protein PatM Probably part of a binding-protein-dependent transport system for an amino acid. Probably responsible for the translocation of the substrate across the membrane. Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily%3B Contains 1 ABC transmembrane type-1 domain gene gene204 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00205 VSVS12_00206 VSVS12_00206 VSVS12_00206 218184 218942 - Putative amino-acid ABC transporter-binding protein PatH Probably part of a binding-protein-dependent transport system for an amino acid. Belongs to the bacterial solute-binding protein 3 family gene gene205 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00206 VSVS12_00207 VSVS12_00207 VSVS12_00207 219367 220773 + Chromosomal replication initiator protein DnaA Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replicatio%3B it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids%3B Belongs to the DnaA family gene gene206 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00207 VSVS12_00208 VSVS12_00208 dnaN dnaN 220860 221960 + DNA-directed DNA polymerase DNA polymerase III is a complex%2C multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA%2C it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)%3B KEGG: vch:VC0013 DNA polymerase III subunit beta gene gene207 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00208 VSVS12_00209 VSVS12_00209 VSVS12_00209 221962 223041 + DNA replication and repair protein RecF The RecF protein is involved in DNA metabolis%3B it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded%2C linear DNA. It also seems to bind ATP%3B Belongs to the RecF family gene gene208 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00209 VSVS12_00210 VSVS12_00210 gyrB gyrB 223059 225479 + DNA topoisomerase (ATP-hydrolyzing) DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings%2C including catenanes and knotted rings%3B Belongs to the type II topoisomerase family%3B Contains 1 Toprim domain%3B KEGG: vch:VC0015 DNA gyrase subunit B gene gene209 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00210 VSVS12_00211 VSVS12_00211 VSVS12_00211 226019 226456 + Small heat shock protein IbpA Associates with aggregated proteins%2C together with IbpB%2C to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress. Aggregated proteins bound to the IbpAB complex are more efficiently refolded and reactivated by the ATP-dependent chaperone systems ClpB and DnaK/DnaJ/GrpE. Its activity is ATP- independent%3B Belongs to the small heat shock protein (HSP20) family gene gene210 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00211 VSVS12_00212 VSVS12_00212 avtA avtA 226570 227817 - Valine--pyruvate transaminase Involved in the biosynthesis of alanine%3B Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family%3B KEGG: sgl:SG0009 valine--pyruvate aminotransferase gene gene211 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00212 VSVS12_00213 VSVS12_00213 glyS glyS 228024 230090 - Glycine--tRNA ligase Belongs to the class-II aminoacyl-tRNA synthetase family%3B KEGG: lca:LSEI_1503 glycyl-tRNA synthetase beta chain gene gene212 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00213 VSVS12_00214 VSVS12_00214 glyQ glyQ 230094 231032 - Glycine--tRNA ligase Belongs to the class-II aminoacyl-tRNA synthetase family%3B KEGG: eco:b3560 glycyl-tRNA synthetase alpha chain gene gene213 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00214 VSVS12_00215 VSVS12_00215 VSVS12_00215 231624 233297 + hypothetical protein gene gene214 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00215 VSVS12_00216 VSVS12_00216 VSVS12_00216 233512 233772 + hypothetical protein gene gene215 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00216 VSVS12_00217 VSVS12_00217 tusA tusA 233831 234079 - Sulfurtransferase TusA like protein Could be part of a sulfur-relay system%3B Belongs to the UPF0033 family. TusA subfamily%3B KEGG: vtu:IX91_00060 tRNA 2-thiouridine synthesizing protein A%3B Sulfurtransferases gene gene216 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00217 VSVS12_00218 VSVS12_00218 VSVS12_00218 234565 235506 + putative HTH-type transcriptional regulator YbdO Contains 1 HTH lysR-type DNA-binding domain gene gene217 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00218 VSVS12_00219 VSVS12_00219 VSVS12_00219 235621 236601 - Alcohol dehydrogenase Probably catalyzes the NADPH-dependent reduction of acrylyl-CoA to propanoyl-CoA%3B Belongs to the zinc-containing alcohol dehydrogenase family. Acrylyl-CoA reductase subfamily%3B KEGG: pub:SAR11_1244 alcohol dehydrogenase gene gene218 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00219 VSVS12_00220 VSVS12_00220 ilvA ilvA 236815 238377 - Threonine ammonia-lyase Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate)%2C which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell%2C the second step is accelerated by RidA (By similarity)%3B Belongs to the serine/threonine dehydratase family%3B Contains 2 ACT-like domains%3B KEGG: eta:ETA_01880 threonine dehydratase gene gene219 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00220 VSVS12_00221 VSVS12_00221 ilvD ilvD 238381 240222 - Dihydroxy-acid dehydratase Belongs to the IlvD/Edd family%3B KEGG: eco:b3771 dihydroxy-acid dehydratase gene gene220 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00221 VSVS12_00222 VSVS12_00222 ilvE ilvE 240238 241182 - Branched-chain-amino-acid transaminase Acts on leucine%2C isoleucine and valine%3B Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family%3B KEGG: vch:VC0029 branched-chain amino acid aminotransferase gene gene221 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00222 VSVS12_00223 VSVS12_00223 ilvM ilvM 241196 241480 - Acetolactate synthase KEGG: vch:VC0030 acetolactate synthase II small subunit gene gene222 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00223 VSVS12_00224 VSVS12_00224 ilvB ilvB 241482 243128 - Acetolactate synthase Belongs to the TPP enzyme family%3B KEGG: eco:b0077 acetolactate synthase I/II/III large subunit gene gene223 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00224 VSVS12_00225 VSVS12_00225 VSVS12_00225 243630 243872 + Competence protein ComM Induced during competence development. Not needed for DNA uptake. May be involved in a recombination step. Belongs to the Mg-chelatase subunits D/I family. ComM subfamily gene gene224 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00225 VSVS12_00226 VSVS12_00226 VSVS12_00226 243976 244200 + hypothetical protein gene gene225 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00226 VSVS12_00227 VSVS12_00227 VSVS12_00227 244546 245721 + hypothetical protein gene gene226 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00227 VSVS12_00228 VSVS12_00228 VSVS12_00228 245751 245954 - hypothetical protein gene gene227 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00228 VSVS12_00229 VSVS12_00229 VSVS12_00229 245956 246183 - hypothetical protein gene gene228 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00229 VSVS12_00230 VSVS12_00230 VSVS12_00230 246176 246337 - hypothetical protein gene gene229 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00230 VSVS12_00231 VSVS12_00231 VSVS12_00231 246312 247001 - hypothetical protein gene gene230 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00231 VSVS12_00232 VSVS12_00232 VSVS12_00232 247459 249159 - uncharacterized protein Contains 1 recombinase DNA-binding domain%3B Contains 1 resolvase/invertase-type recombinase catalytic domain gene gene231 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00232 VSVS12_00233 VSVS12_00233 VSVS12_00233 249275 250003 + Competence protein ComM Induced during competence development. Not needed for DNA uptake. May be involved in a recombination step. Belongs to the Mg-chelatase subunits D/I family. ComM subfamily gene gene232 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00233 VSVS12_00234 VSVS12_00234 VSVS12_00234 250092 252431 + hypothetical protein gene gene233 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00234 VSVS12_00235 VSVS12_00235 VSVS12_00235 252425 254836 + hypothetical protein gene gene234 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00235 VSVS12_00236 VSVS12_00236 VSVS12_00236 254847 255377 + hypothetical protein gene gene235 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00236 VSVS12_00237 VSVS12_00237 VSVS12_00237 255377 256744 + hypothetical protein gene gene236 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00237 VSVS12_00238 VSVS12_00238 VSVS12_00238 256817 257410 - hypothetical protein gene gene237 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00238 VSVS12_00239 VSVS12_00239 VSVS12_00239 257433 258206 - hypothetical protein gene gene238 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00239 VSVS12_00240 VSVS12_00240 VSVS12_00240 258376 258678 - hypothetical protein gene gene239 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00240 VSVS12_00241 VSVS12_00241 VSVS12_00241 259269 259883 + Competence protein ComM Induced during competence development. Not needed for DNA uptake. May be involved in a recombination step. Belongs to the Mg-chelatase subunits D/I family. ComM subfamily gene gene240 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00241 VSVS12_00242 VSVS12_00242 VSVS12_00242 259959 260945 - hypothetical protein gene gene241 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00242 VSVS12_00243 VSVS12_00243 VSVS12_00243 261505 262107 - Thiol:disulfide interchange protein DsbA Involved in disulfide-bond formation. Required for the functional maturation of secreted virulence factors. Acts by transferring its disulfide bond to other proteins. Belongs to the thioredoxin family. DsbA subfamily%3B Contains 1 thioredoxin domain gene gene242 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00243 VSVS12_00244 VSVS12_00244 VSVS12_00244 262139 263125 - Serine/threonine protein kinase RdoA A protein kinase that (auto)phosphorylates on Ser and Thr residues%2C probably involved in the extracytoplasmic stress response (PubMed:12511488). Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species (By similarity)%3B Belongs to the SrkA/RdoA protein kinase family gene gene243 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00244 VSVS12_00245 VSVS12_00245 VSVS12_00245 263179 264597 - Nitrogen fixation protein FixG FixG is predicted to be involved in a redox process. The four proteins FixG%2C FixH%2C FixI%2C and FixS may participate in a membrane-bound complex coupling the FixI cation pump with a redox process catalyzed by FixG. Contains 1 4Fe-4S ferredoxin-type domain gene gene244 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00245 VSVS12_00246 VSVS12_00246 VSVS12_00246 264886 265152 - uncharacterized protein To E. coli YihD gene gene245 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00246 VSVS12_00247 VSVS12_00247 VSVS12_00247 265911 266708 + Sporulation-control protein spo0M Controls the expression of spo0A and is required to pass the morphological stage 0 of sporulation%3B Belongs to the spo0M family gene gene246 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00247 VSVS12_00248 VSVS12_00248 VSVS12_00248 266794 267447 + UPF0073 inner membrane protein YqfA Belongs to the UPF0073 (Hly-III) family gene gene247 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00248 VSVS12_00249 VSVS12_00249 VSVS12_00249 267444 268889 - Trk system potassium uptake protein TrkI Medium-affinity potassium transport system. Probably interacts with Trk system potassium uptake protein TrkA. Main K(+) transporter in osmotically adapted cells%3B Belongs to the TrkH potassium transport family gene gene248 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00249 VSVS12_00250 VSVS12_00250 VSVS12_00250 268903 270279 - Trk system potassium uptake protein TrkA Part of a potassium transport system%3B Contains 2 RCK C-terminal domains%3B Contains 2 RCK N-terminal domains gene gene249 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00250 VSVS12_00251 VSVS12_00251 rsmB rsmB 270440 271720 - 16S rRNA (cytosine(967)-C(5))-methyltransferase Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA%3B Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family%3B KEGG: hpr:PARA_06680 16S rRNA (cytosine967-C5)-methyltransferase gene gene250 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00251 VSVS12_00252 VSVS12_00252 VSVS12_00252 271860 272807 - Methionyl-tRNA formyltransferase Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by: (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP%3B Belongs to the Fmt family%3B KEGG: msu:MS2202 methionyl-tRNA formyltransferase gene gene251 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00252 VSVS12_00253 VSVS12_00253 VSVS12_00253 272826 273335 - Peptide deformylase Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions%3B Belongs to the polypeptide deformylase family%3B KEGG: xbv:XBW1_3930 peptide deformylase gene gene252 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00253 VSVS12_00254 VSVS12_00254 VSVS12_00254 273506 274441 + hypothetical protein gene gene253 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00254 VSVS12_00255 VSVS12_00255 VSVS12_00255 274445 275587 + Protein smf Essential for efficient chromosomal DNA transformation but not required for plasmid transformation%3B Belongs to the smf family gene gene254 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00255 VSVS12_00256 VSVS12_00256 VSVS12_00256 275584 276060 + Protein Smg like protein Belongs to the Smg family gene gene255 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00256 VSVS12_00257 VSVS12_00257 VSVS12_00257 276182 276760 + DNA topoisomerase Releases the supercoiling and torsional tension of DNA%2C which is introduced during the DNA replication and transcription%2C by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme%2C resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand%2C thus removing DNA supercoils. Finally%2C in the religation step%2C the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone%3B Belongs to the type IA topoisomerase family%3B Contains 1 Toprim domain gene gene256 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00257 VSVS12_00258 VSVS12_00258 purK purK 276815 277624 - 5-(carboxyamino)imidazole ribonucleotide synthase Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)%3B Belongs to the PurK/PurT family%3B Contains 1 ATP-grasp domain%3B KEGG: lcn:C270_05010 5-(carboxyamino)imidazole ribonucleotide synthase%3B overlaps another CDS with the same product name gene gene257 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00258 VSVS12_00259 VSVS12_00259 VSVS12_00259 277621 277956 - 5-(carboxyamino)imidazole ribonucleotide synthase Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)%3B Belongs to the PurK/PurT family%3B Contains 1 ATP-grasp domain%3B KEGG: vch:VC0051 5-(carboxyamino)imidazole ribonucleotide synthase%3B overlaps another CDS with the same product name gene gene258 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00259 VSVS12_00260 VSVS12_00260 purE purE 277960 278445 - 5-(carboxyamino)imidazole ribonucleotide mutase Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)%3B Belongs to the AIR carboxylase family. Class I subfamily%3B KEGG: xfa:XF2672 5-(carboxyamino)imidazole ribonucleotide mutase gene gene259 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00260 VSVS12_00261 VSVS12_00261 tsaC tsaC 278641 279198 + L-threonylcarbamoyladenylate synthase Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Catalyzes the conversion of L-threonine%2C HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate%2C with the release of diphosphate%3B Belongs to the SUA5 family. TsaC subfamily%3B Contains 1 YrdC-like domain%3B KEGG: vcy:IX92_15755 L-threonylcarbamoyladenylate synthase gene gene260 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00261 VSVS12_00262 VSVS12_00262 cpoX cpoX 279260 280180 + Coproporphyrinogen oxidase Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX%3B Belongs to the aerobic coproporphyrinogen-III oxidase family%3B KEGG: vch:VC0055 coproporphyrinogen III oxidase gene gene261 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00262 VSVS12_00263 VSVS12_00263 aroE aroE 280249 281082 + Shikimate dehydrogenase Involved in the biosynthesis of the chorismate%2C which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)%3B Belongs to the shikimate dehydrogenase family%3B KEGG: vvu:VV1_1057 shikimate dehydrogenase gene gene262 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00263 VSVS12_00264 VSVS12_00264 VSVS12_00264 281082 281348 + hypothetical protein gene gene263 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00264 VSVS12_00265 VSVS12_00265 VSVS12_00265 281341 281889 - Protein YrdA Belongs to the gamma-class carbonic anhydrase family gene gene264 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00265 VSVS12_00266 VSVS12_00266 VSVS12_00266 282452 283998 + 16S ribosomal RNA rRNA gene265 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00266 VSVS12_00267 VSVS12_00267 VSVS12_00267 284092 284167 + tRNA-Glu tRNA gene266 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00267 VSVS12_00268 VSVS12_00268 VSVS12_00268 284172 284247 + tRNA-Lys tRNA gene267 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00268 VSVS12_00269 VSVS12_00269 VSVS12_00269 284281 284356 + tRNA-Val tRNA gene268 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00269 VSVS12_00270 VSVS12_00270 VSVS12_00270 284700 287593 + 23S ribosomal RNA rRNA gene269 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00270 VSVS12_00271 VSVS12_00271 VSVS12_00271 287686 287801 + 5S ribosomal RNA rRNA gene270 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00271 VSVS12_00272 VSVS12_00272 VSVS12_00272 287905 287995 + tRNA-Ser tRNA gene271 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00272 VSVS12_00273 VSVS12_00273 VSVS12_00273 288242 289246 - Adenosine deaminase Belongs to the adenosine and AMP deaminases family. Adenosine deaminase subfamily%3B KEGG: pge:LG71_15775 adenosine deaminase gene gene272 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00273 VSVS12_00274 VSVS12_00274 VSVS12_00274 289345 291879 - Diguanylate cyclase DosC Globin-coupled heme-based oxygen sensor protein displaying diguanylate cyclase (DGC) activity in response to oxygen availability. Thus%2C catalyzes the synthesis of cyclic diguanylate (c-di-GMP) via the condensation of 2 GTP molecules. Cyclic-di-GMP is a second messenger which controls cell surface- associated traits in bacteria (By similarity)%3B Contains 1 GGDEF domain gene gene273 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00274 VSVS12_00275 VSVS12_00275 VSVS12_00275 292045 293448 - Transcriptional regulatory protein FixJ FixJ%2C when activated by FixL%2C induces the expression of both nifA%2C required for activation of classical nif and fix genes%2C and fixK%2C required for FixN activation. Contains 1 HTH luxR-type DNA-binding domain%3B Contains 1 response regulatory domain gene gene274 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00275 VSVS12_00276 VSVS12_00276 glnL glnL 293488 294537 - Histidine kinase NtrB acts as a signal transducer which responds to the nitrogen level of cell and modulates the activity of NtrC. In nitrogen limitation NtrB activates NtrC by phosphorylating it%2C while in nitrogen excess NtrC is dephosphorylated and consequently inactivated by NtrB (By similarity)%3B Contains 1 histidine kinase domain%3B Contains 1 PAS (PER-ARNT-SIM) domain%3B KEGG: vcy:IX92_15680 two-component system%2C NtrC family%2C nitrogen regulation sensor histidine kinase GlnL gene gene275 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00276 VSVS12_00277 VSVS12_00277 glnA glnA 294873 296282 - Glutamate--ammonia ligase Belongs to the glutamine synthetase family%3B KEGG: sgl:SG2230 glutamine synthetase gene gene276 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00277 VSVS12_00278 VSVS12_00278 VSVS12_00278 296856 298688 + Elongation factor Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction%2C by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex%2C thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner%3B Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily%3B Contains 1 tr-type G (guanine nucleotide-binding) domain gene gene277 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00278 VSVS12_00279 VSVS12_00279 VSVS12_00279 298824 299363 + hypothetical protein gene gene278 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00279 VSVS12_00280 VSVS12_00280 VSVS12_00280 299367 300008 - hypothetical protein gene gene279 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00280 VSVS12_00281 VSVS12_00281 VSVS12_00281 300071 301006 + UPF0761 membrane protein Belongs to the UPF0761 family gene gene280 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00281 VSVS12_00282 VSVS12_00282 dtd1 dtd1 300978 301412 + D-tyrosyl-tRNA(Tyr) deacylase ATPase involved in DNA replication%2C may facilitate loading of CDC45 onto pre-replication complexes. May hydrolyze D- tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr)%2C a possible defense mechanism against a harmful effect of D-tyrosine (By similarity)%3B Belongs to the DTD family%3B KEGG: eco:b3887 D-tyrosyl-tRNA(Tyr) deacylase%3B Acting on ester bonds gene gene281 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00282 VSVS12_00283 VSVS12_00283 VSVS12_00283 301522 302451 + uncharacterized protein Contains 1 N-acetyltransferase domain%3B KEGG: vfi:VF_0102 null%3B Transferring groups other than amino-acyl groups gene gene282 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00283 VSVS12_00284 VSVS12_00284 VSVS12_00284 302415 304334 - hypothetical protein gene gene283 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00284 VSVS12_00285 VSVS12_00285 pckA pckA 304446 306074 - Phosphoenolpyruvate carboxykinase (ATP) Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA%3B Belongs to the phosphoenolpyruvate carboxykinase [ATP] family%3B KEGG: vch:VC2738 phosphoenolpyruvate carboxykinase (ATP) gene gene284 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00285 VSVS12_00286 VSVS12_00286 VSVS12_00286 306411 307301 - 33 kDa chaperonin Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress%3B Belongs to the HSP33 family gene gene285 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00286 VSVS12_00287 VSVS12_00287 VSVS12_00287 307316 307702 - Heat shock protein 15 like protein May play a important role in binding of nucleic acid. More specific for RNA (By similarity)%3B Belongs to the HSP15 family%3B Contains 1 S4 RNA-binding domain gene gene286 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00287 VSVS12_00288 VSVS12_00288 VSVS12_00288 307937 308815 + Type II secretion system protein Involved in a type II secretion system (T2SS%2C formerly general secretion pathway%2C GSP) for the export of proteins (By similarity). Required for secretion of cholera toxin through the outer membrane%3B Belongs to the GSP C family gene gene287 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00288 VSVS12_00289 VSVS12_00289 VSVS12_00289 308852 310876 + Type II secretion system protein Involved in a type II secretion system (T2SS%2C formerly general secretion pathway%2C GSP) for the export of proteins (By similarity). Required for secretion of cholera toxin through the outer membrane%3B Belongs to the GSP D family%3B overlaps another CDS with the same product name gene gene288 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00289 VSVS12_00290 VSVS12_00290 VSVS12_00290 310873 312366 + Type II secretion system protein Involved in a type II secretion system (T2SS%2C formerly general secretion pathway%2C GSP) for the export of proteins. Required for secretion of cholera toxin through the outer membrane. Belongs to the GSP E family%3B overlaps another CDS with the same product name gene gene289 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00290 VSVS12_00291 VSVS12_00291 VSVS12_00291 312366 313595 + Type II secretion system protein Involved in a type II secretion system (T2SS%2C formerly general secretion pathway%2C GSP) for the export of proteins (By similarity). Required for secretion of cholera toxin through the outer membrane%3B Belongs to the GSP F family%3B overlaps another CDS with the same product name gene gene290 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00291 VSVS12_00292 VSVS12_00292 VSVS12_00292 313630 314076 + Type II secretion system protein Involved in a type II secretion system (T2SS%2C formerly general secretion pathway%2C GSP) for the export of proteins%3B Belongs to the GSP G family gene gene291 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00292 VSVS12_00293 VSVS12_00293 VSVS12_00293 314175 314768 + Type II secretion system protein Involved in a type II secretion system (T2SS%2C formerly general secretion pathway%2C GSP) for the export of proteins (By similarity). Required for secretion of cholera toxin through the outer membrane%3B Belongs to the GSP H family%3B overlaps another CDS with the same product name gene gene292 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00293 VSVS12_00294 VSVS12_00294 VSVS12_00294 314758 315159 + Type II secretion system protein Involved in a type II secretion system (T2SS%2C formerly general secretion pathway%2C GSP) for the export of proteins (By similarity). Required for secretion of cholera toxin through the outer membrane%3B Belongs to the GSP I family%3B overlaps another CDS with the same product name gene gene293 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00294 VSVS12_00295 VSVS12_00295 VSVS12_00295 315146 315817 + Type II secretion system protein J Involved in a type II secretion system (T2SS%2C formerly general secretion pathway%2C GSP) for the export of proteins (By similarity). Required for secretion of cholera toxin through the outer membrane%3B Belongs to the GSP J family gene gene294 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00295 VSVS12_00296 VSVS12_00296 VSVS12_00296 315807 316820 + Type II secretion system protein K Involved in a type II secretion system (T2SS%2C formerly general secretion pathway%2C GSP) for the export of proteins (By similarity). Required for the translocation of the multiple pectic enzymes%3B Belongs to the GSP K family gene gene295 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00296 VSVS12_00297 VSVS12_00297 VSVS12_00297 316786 317997 + Type II secretion system protein Involved in a type II secretion system (T2SS%2C formerly general secretion pathway%2C GSP) for the export of proteins (By similarity). Required for secretion of cholera toxin through the outer membrane%3B Belongs to the GSP L family gene gene296 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00297 VSVS12_00298 VSVS12_00298 VSVS12_00298 318008 318499 + Type II secretion system protein M Involved in a type II secretion system (T2SS%2C formerly general secretion pathway%2C GSP) for the export of proteins (By similarity). Required for secretion of cholera toxin through the outer membrane%3B Belongs to the GSP M family gene gene297 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00298 VSVS12_00299 VSVS12_00299 VSVS12_00299 318506 319267 + Type II secretion system protein Involved in a type II secretion system (T2SS%2C formerly general secretion pathway%2C GSP) for the export of proteins (By similarity). Required for secretion of cholera toxin through the outer membrane%3B Belongs to the GSP N family gene gene298 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00299 VSVS12_00300 VSVS12_00300 envZ envZ 319345 320649 - Histidine kinase Member of the two-component regulatory system EnvZ/OmpR involved in the regulation of osmoregulation (genes ompF and ompC). EnvZ functions as a membrane-associated protein kinase that phosphorylates OmpR in response to environmental signals. Contains 1 HAMP domain%3B Contains 1 histidine kinase domain%3B KEGG: vch:VC2713 two-component system%2C OmpR family%2C osmolarity sensor histidine kinase EnvZ gene gene299 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00300 VSVS12_00301 VSVS12_00301 VSVS12_00301 320748 321467 - Acetoacetate metabolism regulatory protein Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis. Contains 1 response regulatory domain%3B Contains 1 sigma-54 factor interaction domain gene gene300 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00301 VSVS12_00302 VSVS12_00302 VSVS12_00302 321794 322282 + Transcription elongation factor GreB Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through%2C resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreB releases sequences of up to 9 nucleotides in length%3B Belongs to the GreA/GreB family. GreB subfamily gene gene301 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00302 VSVS12_00303 VSVS12_00303 VSVS12_00303 322390 322827 - uncharacterized protein gene gene302 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00303 VSVS12_00304 VSVS12_00304 VSVS12_00304 322948 323880 + RuBisCO operon transcriptional regulator Trans-acting transcriptional regulator of RuBisCO genes (rbcAB) expression. Contains 1 HTH lysR-type DNA-binding domain gene gene303 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00304 VSVS12_00305 VSVS12_00305 VSVS12_00305 324024 326354 + uncharacterized protein Contains 1 S1 motif domain gene gene304 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00305 VSVS12_00306 VSVS12_00306 VSVS12_00306 326486 326956 - hypothetical protein gene gene305 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00306 VSVS12_00307 VSVS12_00307 bioH bioH 327048 327881 - Pimeloyl-[acyl-carrier protein] methyl ester esterase The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters%3B Belongs to the AB hydrolase superfamily. Carboxylesterase BioH family%3B KEGG: psu:Psesu_2980 pimeloyl-(acyl-carrier protein) methyl ester esterase gene gene306 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00307 VSVS12_00308 VSVS12_00308 VSVS12_00308 328171 328710 + Protein GntX Could be involved in gluconate metabolism%3B Belongs to the ComF/GntX family gene gene307 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00308 VSVS12_00309 VSVS12_00309 VSVS12_00309 328818 329405 + Fe/S bioproteinis protein NfuA Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster%2C can transfer this cluster to apoproteins%2C and thereby intervenes in the maturation of Fe/S proteins. Could also act as a scaffold/chaperone for damaged Fe/S proteins%3B Belongs to the NfuA family gene gene308 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00309 VSVS12_00310 VSVS12_00310 nudE nudE 329650 330198 + ADP compounds hydrolase NudE Active on adenosine(5')triphospho(5')adenosine (Ap3A)%2C ADP-ribose%2C NADH%2C adenosine(5')diphospho(5')adenosine (Ap2A). Belongs to the Nudix hydrolase family%3B Contains 1 nudix hydrolase domain%3B KEGG: vpa:VP0145 ADP-ribose diphosphatase%3B In phosphorus-containing anhydrides gene gene309 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00310 VSVS12_00311 VSVS12_00311 cysQ cysQ 330224 331051 + 3'(2')%2C5'-bisphosphate nucleotidase Responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides and has been implicated as the pharmacological target for lithium action in brain. Has broad substrate specificity and can use myo- inositol monophosphates%2C myo-inositol 1%2C3-diphosphate%2C myo- inositol 1%2C4-diphosphate%2C scyllo-inositol-phosphate%2C D-galactose 1-phosphate%2C glucose-1-phosphate%2C glucose-6-phosphate%2C fructose-1- phosphate%2C beta-glycerophosphate%2C and 2'-AMP as substrates%3B Belongs to the inositol monophosphatase family%3B KEGG: vcy:IX92_15515 3'(2')%2C 5'-bisphosphate nucleotidase gene gene310 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00311 VSVS12_00312 VSVS12_00312 VSVS12_00312 331629 334274 + Beta-N-acetylhexosaminidase Hydrolysis of terminal%2C non-reducing N-acetyl-beta-D- glucosamine residues in chitobiose and higher analogs%2C and in glycoproteins. Belongs to the glycosyl hydrolase 20 family%3B KEGG: awd:AWOD_II_1174 hexosaminidase gene gene311 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00312 VSVS12_00313 VSVS12_00313 recG recG 334693 336771 - DNA helicase Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA). Has a role in constitutive stable DNA replication (CsdR) and R-loop formation (By similarity)%3B Belongs to the helicase family. RecG subfamily%3B Contains 1 helicase ATP-binding domain%3B Contains 1 helicase C-terminal domain%3B KEGG: vch:VC2711 ATP-dependent DNA helicase RecG gene gene312 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00313 VSVS12_00314 VSVS12_00314 trmH trmH 337072 337755 - tRNA (guanosine(18)-2'-O)-methyltransferase Specifically methylates guanosine-18 in various tRNAs%3B Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family%3B KEGG: vha:VIBHAR_00626 tRNA (guanosine-2'-O-)-methyltransferase gene gene313 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00314 VSVS12_00315 VSVS12_00315 spoT spoT 337821 339941 - Guanosine-3'%2C5'-bis(diphosphate) 3'-diphosphatase In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance%3B Belongs to the RelA/SpoT family%3B Contains 1 ACT domain%3B Contains 1 HD domain%3B KEGG: vch:VC2710 guanosine-3'%2C5'-bis(diphosphate) 3'-pyrophosphohydrolase gene gene314 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00315 VSVS12_00316 VSVS12_00316 rpoZ rpoZ 339979 340251 - DNA-directed RNA polymerase Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits%3B Belongs to the RNA polymerase subunit omega family%3B KEGG: eco:b3649 DNA-directed RNA polymerase subunit omega gene gene315 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00316 VSVS12_00317 VSVS12_00317 VSVS12_00317 340364 340987 - Guanylate kinase Essential for recycling GMP and indirectly%2C cGMP%3B Belongs to the guanylate kinase family%3B Contains 1 guanylate kinase-like domain%3B KEGG: pfq:QQ39_00835 guanylate kinase gene gene316 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00317 VSVS12_00318 VSVS12_00318 VSVS12_00318 341095 341262 + hypothetical protein gene gene317 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00318 VSVS12_00319 VSVS12_00319 VSVS12_00319 341524 342894 + Adenine permease AdeQ High-affinity transporter for adenine%3B Belongs to the xanthine/uracil permease family. AzgA purine transporter (TC 2. A. 1. 40) subfamily gene gene318 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00319 VSVS12_00320 VSVS12_00320 VSVS12_00320 343021 343446 + hypothetical protein gene gene319 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00320 VSVS12_00321 VSVS12_00321 pdxK pdxK 343726 344589 + Pyridoxal kinase Phosphorylates B6 vitamer%3B functions in a salvage pathway. Uses pyridoxamine%3B Belongs to the pyridoxine kinase family%3B KEGG: vvu:VV2_1237 pyridoxine kinase gene gene320 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00321 VSVS12_00322 VSVS12_00322 VSVS12_00322 344676 345542 - Inositol-phosphate phosphatase Belongs to the UPF0701 family%3B KEGG: gsl:Gasu_46960 inositol-phosphate phosphatase / L-galactose 1-phosphate phosphatase / histidinol-phosphatase gene gene321 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00322 VSVS12_00323 VSVS12_00323 VSVS12_00323 345739 346455 + tRNA nucleotidyltransferase Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates%3B Belongs to the RNase PH family%3B KEGG: vpa:VP0177 ribonuclease PH gene gene322 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00323 VSVS12_00324 VSVS12_00324 pyrE pyrE 346674 347315 + Orotate phosphoribosyltransferase Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate%2C leading to the formation of orotidine monophosphate (OMP)%3B Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily%3B KEGG: ype:YPO0045 orotate phosphoribosyltransferase gene gene323 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00324 VSVS12_00325 VSVS12_00325 lpxL lpxL 347552 348502 - Kdo(2)-lipid IV(A) lauroyltransferase Catalyzes the transfer of laurate from lauroyl-acyl carrier protein (ACP) to Kdo(2)-lipid IV(A) to form Kdo(2)- (lauroyl)-lipid IV(A)%3B Belongs to the LpxL/LpxM/LpxP family%3B KEGG: vch:VC0213 KDO2-lipid IV(A) lauroyltransferase gene gene324 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00325 VSVS12_00326 VSVS12_00326 VSVS12_00326 348560 349150 - Nucleoid occlusion factor SlmA Required for nucleoid occlusion (NO) phenomenon%2C which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ%2C and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome%2C preventing FtsZ polymerization at these regions%3B Belongs to the nucleoid occlusion factor SlmA family%3B Contains 1 HTH tetR-type DNA-binding domain gene gene325 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00326 VSVS12_00327 VSVS12_00327 VSVS12_00327 349265 350464 - Phosphopantothenoylcysteine decarboxylase Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine%2C in the latter compound is decarboxylated to form 4'-phosphopantotheine (By similarity)%3B In the N-terminal sectio%3B belongs to the HFCD (homo- oligomeric flavin containing Cys decarboxylase) superfamily%3B In the C-terminal sectio%3B belongs to the PPC synthetase family%3B KEGG: ecf:ECH74115_5009 phosphopantothenoylcysteine decarboxylase / phosphopantothenate--cysteine ligase gene gene326 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00327 VSVS12_00328 VSVS12_00328 VSVS12_00328 350703 352382 + Sensor histidine kinase MctS Member of the two-component regulatory system MctS/MctR%2C which activates mctP expression%3B Contains 1 histidine kinase domain gene gene327 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00328 VSVS12_00329 VSVS12_00329 VSVS12_00329 352345 353178 + UPF0758 protein Belongs to the UPF0758 family gene gene328 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00329 VSVS12_00330 VSVS12_00330 VSVS12_00330 353460 353696 + 50S ribosomal protein L28 Belongs to the ribosomal protein L28P family gene gene329 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00330 VSVS12_00331 VSVS12_00331 VSVS12_00331 353711 353881 + 50S ribosomal protein L33 Belongs to the ribosomal protein L33P family gene gene330 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00331 VSVS12_00332 VSVS12_00332 VSVS12_00332 354004 354504 + hypothetical protein gene gene331 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00332 VSVS12_00333 VSVS12_00333 mutM mutM 354516 355322 + DNA-formamidopyrimidine glycosylase Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines%2C such as 7%2C8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates%3B Belongs to the FPG family%3B Contains 1 FPG-type zinc finger%3B KEGG: eco:b3635 formamidopyrimidine-DNA glycosylase gene gene332 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00333 VSVS12_00334 VSVS12_00334 coaD coaD 355332 355826 - Pantetheine-phosphate adenylyltransferase Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine%2C yielding dephospho-CoA (dPCoA) and pyrophosphate%3B Belongs to the bacterial CoaD family%3B KEGG: vch:VC0222 pantetheine-phosphate adenylyltransferase gene gene333 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00334 VSVS12_00335 VSVS12_00335 VSVS12_00335 355951 356982 + uncharacterized protein KEGG: hpk:Hprae_0259 heptosyltransferase I%3B Glycosyltransferases gene gene334 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00335 VSVS12_00336 VSVS12_00336 waaE waaE 357031 357825 - putative glycosyltransferase Belongs to the glycosyltransferase 2 family. WaaE/KdtX subfamily%3B KEGG: vcx:VAA049_3477 (heptosyl)LPS beta-1%2C4-glucosyltransferase%3B Hexosyltransferases%3B overlaps another CDS with the same product name gene gene335 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00336 VSVS12_00337 VSVS12_00337 opsX opsX 357815 358873 - Putative glycosyltransferase Belongs to the glycosyltransferase 9 family%3B KEGG: vvu:VV1_0816 heptosyltransferase I%3B Glycosyltransferases%3B overlaps another CDS with the same product name gene gene336 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00337 VSVS12_00338 VSVS12_00338 VSVS12_00338 358972 359349 + Diacylglycerol kinase (ATP) Recycling of diacylglycerol produced during the turnover of membrane phospholipid%3B Belongs to the bacterial diacylglycerol kinase family%3B KEGG: mvs:MVIS_3965 diacylglycerol kinase (ATP) gene gene337 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00338 VSVS12_00339 VSVS12_00339 kdkA kdkA 359366 360079 + 3-deoxy-D-manno-octulosonic acid kinase Catalyzes the ATP-dependent phosphorylation of the 3- deoxy-D-manno-octulosonic acid (Kdo) residue in Kdo-lipid IV(A) at the 4-OH position%3B Belongs to the protein kinase superfamily. KdkA/RfaP family%3B KEGG: vch:VC0227 3-deoxy-D-manno-octulosonic acid kinase gene gene338 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00339 VSVS12_00340 VSVS12_00340 VSVS12_00340 360099 361934 + Inner membrane protein To H. influenzae HI_0842 gene gene339 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00340 VSVS12_00341 VSVS12_00341 VSVS12_00341 361977 362969 - hypothetical protein gene gene340 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00341 VSVS12_00342 VSVS12_00342 pseB pseB 363153 364166 + UDP-N-acetylglucosamine 4%2C6-dehydratase (inverting) Epimerizes UDP-galactose to UDP-glucose%3B Belongs to the polysaccharide synthase family%3B KEGG: son:SO_3271 UDP-N-acetylglucosamine 4%2C6-dehydratase gene gene341 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00342 VSVS12_00343 VSVS12_00343 VSVS12_00343 364177 365340 + UDP-4-amino-4%2C6-dideoxy-N-acetyl-beta-L-altrosamine transaminase Catalyzes the second step in the biosynthesis of pseudaminic acid%2C a sialic-acid-like sugar that is used to modify flagellin. Uses UDP-2-acetamido-2%2C6-dideoxy-beta-L-arabino-4- hexulose as substrate producing UDP-4-amino-4%2C6-dideoxy-beta-L- AltNAc%3B Belongs to the DegT/DnrJ/EryC1 family%3B KEGG: gfo:GFO_2027 null%3B Transaminases gene gene342 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00343 VSVS12_00344 VSVS12_00344 VSVS12_00344 365352 366512 + hypothetical protein gene gene343 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00344 VSVS12_00345 VSVS12_00345 hisH hisH 366515 367129 + Imidazole glycerol phosphate synthase subunit HisH IGPS catalyzes the conversion of PRFAR and glutamine to IGP%2C AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR%3B Contains 1 glutamine amidotransferase type-1 domain%3B KEGG: nis:NIS_1412 glutamine amidotransferase%3B Pentosyltransferases gene gene344 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00345 VSVS12_00346 VSVS12_00346 hisF hisF 367131 367886 + Putative imidazole glycerol phosphate synthase subunit hisF2 IGPS catalyzes the conversion of PRFAR and glutamine to IGP%2C AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity)%3B Belongs to the HisA/HisF family%3B KEGG: pae:PA3151 cyclase%3B Oxo-acid-lyases gene gene345 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00346 VSVS12_00347 VSVS12_00347 neuA neuA 367890 368579 + N-acylneuraminate cytidylyltransferase Belongs to the CMP-NeuNAc synthase family%3B KEGG: pwa:Pecwa_3030 N-acylneuraminate cytidylyltransferase gene gene346 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00347 VSVS12_00348 VSVS12_00348 VSVS12_00348 368637 369188 + hypothetical protein gene gene347 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00348 VSVS12_00349 VSVS12_00349 pseG pseG 369164 370084 + UDP-2%2C4-diacetamido-2%2C4%2C6-trideoxy-beta-L-altropyranose hydrolase KEGG: dru:Desru_1220 UDP-2%2C4-diacetamido-2%2C4%2C6-trideoxy-beta-L-altropyranose hydrolase gene gene348 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00349 VSVS12_00350 VSVS12_00350 neuB neuB 370053 371144 + N-acetylneuraminate synthase Catalyzes the fifth step in the biosynthesis of pseudaminic acid%2C a sialic-acid-like sugar that is used to modify flagellin. Catalyzes the condensation of phosphoenolpyruvate with 2%2C4-diacetamido-2%2C4%2C6-trideoxy-beta-l-altropyranose%2C forming pseudaminic acid (By similarity)%3B Belongs to the pseudaminic acid synthase family%3B Contains 1 AFP-like domain%3B KEGG: psh:Psest_1815 N-acetylneuraminate synthase gene gene349 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00350 VSVS12_00351 VSVS12_00351 VSVS12_00351 371246 372256 - hypothetical protein gene gene350 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00351 VSVS12_00352 VSVS12_00352 kdtA kdtA 372290 373588 - Lipid IV(A) 3-deoxy-D-manno-octulosonic acid transferase Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of a single 3-deoxy-D-manno-octulosonate (Kdo) residue from CMP-Kdo to lipid IV(A)%2C the tetraacyldisaccharide-1%2C4'-bisphosphate precursor of lipid A. Is strictly monofunctional%2C i. e. is capable of adding only a single Kdo residue to the acceptor lipid%3B Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 30 subfamily%3B KEGG: vni:VIBNI_A3686 3-deoxy-D-manno-octulosonic-acid transferase gene gene351 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00352 VSVS12_00353 VSVS12_00353 waaF waaF 373582 374640 - ADP-heptose--LPS heptosyltransferase Belongs to the glycosyltransferase 9 family%3B KEGG: vch:VC0236 heptosyltransferase II%3B Glycosyltransferases gene gene352 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00353 VSVS12_00354 VSVS12_00354 lpxM lpxM 374637 375629 - Lauroyl-Kdo(2)-lipid IV(A) myristoyltransferase Catalyzes the transfer of myristate from myristoyl-acyl carrier protein (ACP) to Kdo(2)-(lauroyl)-lipid IV(A) to form Kdo(2)-lipid A. Can probably also catalyze the transfer of myristate to Kdo(2)-(palmitoleoyl)-lipid IV(A) to form the cold- adapted Kdo(2)-lipid A%3B Belongs to the LpxL/LpxM/LpxP family. LpxM subfamily%3B KEGG: vpa:VP0213 lauroyl-KDO2-lipid IV(A) myristoyltransferase gene gene353 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00354 VSVS12_00355 VSVS12_00355 gmhD gmhD 375648 376589 - ADP-glyceromanno-heptose 6-epimerase Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose%3B Belongs to the NAD(P)-dependent epimerase/dehydratase family. HldD subfamily%3B KEGG: eco:b3619 ADP-L-glycero-D-manno-heptose 6-epimerase gene gene354 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00355 VSVS12_00356 VSVS12_00356 pssA pssA 376822 378141 - CDP-diacylglycerol--serine O-phosphatidyltransferase Belongs to the CDP-alcohol phosphatidyltransferase class-II family%3B Contains 2 PLD phosphodiesterase domains%3B KEGG: vfu:vfu_A00050 CDP-diacylglycerol---serine O-phosphatidyltransferase gene gene355 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00356 VSVS12_00357 VSVS12_00357 VSVS12_00357 378267 378701 - hypothetical protein gene gene356 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00357 VSVS12_00358 VSVS12_00358 murB murB 378775 379836 + UDP-N-acetylmuramate dehydrogenase Cell wall formation%3B Belongs to the MurB family%3B Contains 1 FAD-binding PCMH-type domain%3B KEGG: vfu:vfu_A00048 UDP-N-acetylmuramate dehydrogenase gene gene357 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00358 VSVS12_00359 VSVS12_00359 birA birA 379833 380804 + Biotin--[acetyl-CoA-carboxylase] ligase Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP%2C BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase%2C or bind to the biotin operator site and inhibit transcription of the operon%3B Belongs to the biotin--protein ligase family%3B Contains 1 BPL/LPL catalytic domain%3B KEGG: ppr:PBPRA3445 BirA family transcriptional regulator%2C biotin operon repressor / biotin-(acetyl-CoA-carboxylase) ligase gene gene358 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00359 VSVS12_00360 VSVS12_00360 VSVS12_00360 380930 381295 + hypothetical protein gene gene359 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00360 VSVS12_00361 VSVS12_00361 VSVS12_00361 381471 381761 + 10 kDa chaperonin Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter%3B Belongs to the GroES chaperonin family gene gene360 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00361 VSVS12_00362 VSVS12_00362 VSVS12_00362 381959 383605 + 60 kDa chaperonin Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions%3B Belongs to the chaperonin (HSP60) family gene gene361 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00362 VSVS12_00363 VSVS12_00363 VSVS12_00363 383863 385332 + Protein AdrA Contains 1 GGDEF domain gene gene362 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00363 VSVS12_00364 VSVS12_00364 glpX glpX 385405 386412 - Fructose-bisphosphatase Catalyzes the hydrolysis of fructose 1%2C6-bisphosphate to fructose 6-phosphate%3B Belongs to the FBPase class 2 family%3B KEGG: vch:VC2688 fructose-1%2C6-bisphosphatase II gene gene363 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00364 VSVS12_00365 VSVS12_00365 VSVS12_00365 386726 386968 + Cell division protein ZapB Non-essential%2C abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ%2C stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA%3B Belongs to the ZapB family gene gene364 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00365 VSVS12_00366 VSVS12_00366 metF metF 387091 387981 - Methylenetetrahydrofolate reductase (NAD(P)H) Methylenetetrahydrofolate reductase required to generate the methyl groups necessary for methionine synthetase to convert homocysteine to methionine%3B Belongs to the methylenetetrahydrofolate reductase family%3B KEGG: vvu:VV1_1366 methylenetetrahydrofolate reductase (NADPH) gene gene365 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00366 VSVS12_00367 VSVS12_00367 metL metL 388278 390689 - Aspartate kinase In the N-terminal sectio%3B belongs to the aspartokinase family%3B In the C-terminal sectio%3B belongs to the homoserine dehydrogenase family%3B KEGG: vpa:VP2764 bifunctional aspartokinase / homoserine dehydrogenase 2 gene gene366 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00367 VSVS12_00368 VSVS12_00368 metB metB 390690 391856 - Cystathionine gamma-synthase Catalyzes the formation of L-cystathionine from O- succinyl-L-homoserine (OSHS) and L-cysteine%2C via a gamma- replacement reaction. In the absence of thiol%2C catalyzes gamma- elimination to form 2-oxobutanoate%2C succinate and ammonia%3B Belongs to the trans-sulfuration enzymes family%3B KEGG: ctu:CTU_01800 cystathionine gamma-synthase gene gene367 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00368 VSVS12_00369 VSVS12_00369 VSVS12_00369 392098 392415 + Met repressor This regulatory protein%2C when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis%3B Belongs to the MetJ family gene gene368 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00369 VSVS12_00370 VSVS12_00370 maeB maeB 392649 393923 - Malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+)) Required for symbiotic nitrogen fixation. Plays a key role in the conversion of malate to acetyl-CoA for efficient tricarboxylic acid cycle function in nitrogen-fixating bacteria. In the N-terminal sectio%3B belongs to the malic enzymes family%3B In the C-terminal sectio%3B belongs to the phosphate acetyltransferase and butyryltransferase family%3B KEGG: vvu:VV1_1361 malate dehydrogenase (oxaloacetate-decarboxylating)(NADP+) gene gene369 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00370 VSVS12_00371 VSVS12_00371 VSVS12_00371 394170 394388 - 50S ribosomal protein L31 Binds the 23S rRNA%3B Belongs to the ribosomal protein L31P family. Type A subfamily gene gene370 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00371 VSVS12_00372 VSVS12_00372 priA priA 394707 396908 + Primosomal protein N' Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex%2C via its helicase activity%2C and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA%3B Belongs to the helicase family. PriA subfamily%3B Contains 1 helicase ATP-binding domain%3B Contains 1 helicase C-terminal domain%3B KEGG: vch:VC2678 primosomal protein N' (replication factor Y) (superfamily II helicase)%3B Acting on ATP%3B involved in cellular and subcellular movement gene gene371 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00372 VSVS12_00373 VSVS12_00373 VSVS12_00373 397196 398203 + Sucrose operon repressor Repressor for the csc operon. Binds D-fructose as an inducer (By similarity)%3B Contains 1 HTH lacI-type DNA-binding domain gene gene372 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00373 VSVS12_00374 VSVS12_00374 VSVS12_00374 398447 398959 + hypothetical protein gene gene373 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00374 VSVS12_00375 VSVS12_00375 VSVS12_00375 399386 399925 + Transcription antitermination protein Enhances distal genes transcription elongation in a specialized subset of operons that encode extracytoplasmic components. RfaH is recruited into a multi-component RNA polymerase complex by the ops element%2C which is a short conserved DNA sequence located downstream of the main promoter of these operons. Once bound%2C RfaH suppresses pausing and inhibits Rho- dependent and intrinsic termination at a subset of sites. Termination signals are bypassed%2C which allows complete synthesis of long RNA chains%3B Belongs to the RfaH family gene gene374 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00375 VSVS12_00376 VSVS12_00376 wecB wecB 400283 401410 + UDP-N-acetylglucosamine 2-epimerase (non-hydrolyzing) Catalyzes the conversion of UDP-N-acetylglucosamine into UDP-N-acetylmannosamine%2C a precursor of the teichoic acid linkage unit%3B Belongs to the UDP-N-acetylglucosamine 2-epimerase family%3B KEGG: vvu:VV1_0780 UDP-N-acetylglucosamine 2-epimerase (non-hydrolysing) gene gene375 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00376 VSVS12_00377 VSVS12_00377 wecC wecC 401424 402698 + UDP-N-acetyl-D-mannosamine dehydrogenase Catalyzes the four-electron oxidation of UDP-N-acetyl-D- mannosamine (UDP-ManNAc)%2C reducing NAD(+) and releasing UDP-N- acetylmannosaminuronic acid (UDP-ManNAcA)%3B Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. WecC subfamily%3B KEGG: ype:YPO3863 UDP-N-acetyl-D-mannosaminuronic acid dehydrogenase gene gene376 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00377 VSVS12_00378 VSVS12_00378 wbpO wbpO 402695 403969 + Vi polysaccharide biosynthesis protein VipA/TviB Belongs to the UDP-glucose/GDP-mannose dehydrogenase family%3B KEGG: ppno:DA70_17265 UDP-N-acetyl-D-galactosamine dehydrogenase%3B With NAD(+) or NADP(+) as acceptor gene gene377 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00378 VSVS12_00379 VSVS12_00379 wbpP wbpP 404027 405055 + UDP-N-acetylglucosamine 4-epimerase Catalyzes the epimerization of UDP-N-acetylglucosamine (UDP-GlcNAc) to UDP-N-acetylgalactosamine (UDP-GalNAc). Has very low epimerase activity with UDP-Glc and UDP-Gal. Plays a role in the biosynthesis of 2-acetamino-2-deoxy-L-altruronic acid%2C a building block of the O-antigen in bacterial lipopolysaccharide (LPS)%3B Belongs to the NAD(P)-dependent epimerase/dehydratase family%3B KEGG: vcy:IX92_15295 UDP-N-acetylglucosamine 4-epimerase gene gene378 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00379 VSVS12_00380 VSVS12_00380 VSVS12_00380 405066 406346 + Inner membrane protein YghQ gene gene379 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00380 VSVS12_00381 VSVS12_00381 VSVS12_00381 406333 407328 + hypothetical protein gene gene380 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00381 VSVS12_00382 VSVS12_00382 VSVS12_00382 407325 408365 + hypothetical protein gene gene381 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00382 VSVS12_00383 VSVS12_00383 VSVS12_00383 408858 409652 + hypothetical protein gene gene382 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00383 VSVS12_00384 VSVS12_00384 catB catB 409652 410263 + Chloramphenicol O-acetyltransferase This enzyme is an effector of chloramphenicol (Cm) resistance in bacteria. Acetylates Cm but not 1-acetoxy-Cm. Belongs to the transferase hexapeptide repeat family%3B KEGG: ptt:VY86_08795 chloramphenicol O-acetyltransferase type B gene gene383 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00384 VSVS12_00385 VSVS12_00385 VSVS12_00385 410260 411414 + hypothetical protein gene gene384 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00385 VSVS12_00386 VSVS12_00386 VSVS12_00386 411426 412559 + hypothetical protein gene gene385 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00386 VSVS12_00387 VSVS12_00387 VSVS12_00387 412556 413173 + Imidazole glycerol phosphate synthase subunit HisH IGPS catalyzes the conversion of PRFAR and glutamine to IGP%2C AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity)%3B Contains 1 glutamine amidotransferase type-1 domain%3B KEGG: axy:AXYL_06292 glutamine amidotransferase%3B Pentosyltransferases gene gene386 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00387 VSVS12_00388 VSVS12_00388 VSVS12_00388 413166 413927 + Putative imidazole glycerol phosphate synthase subunit hisF2 IGPS catalyzes the conversion of PRFAR and glutamine to IGP%2C AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity)%3B Belongs to the HisA/HisF family%3B KEGG: vvy:VV0356 cyclase%3B Oxo-acid-lyases gene gene387 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00388 VSVS12_00389 VSVS12_00389 VSVS12_00389 413939 416062 + 1%2C5-anhydro-D-fructose reductase Catalyzes the NADPH-specific reduction of 1%2C5-anhydro-D- fructose to 1%2C5-anhydro-D-mannitol. Also shows some activity against structurally related compounds such as 3-keto-1%2C5-anhydro- D-fructose%2C D-glucosone and D-xylosone. The enzyme cannot use NADH as cosubstrate. Belongs to the Gfo/Idh/MocA family%3B KEGG: sat:SYN_02682 null%3B With NAD(+) or NADP(+) as acceptor gene gene388 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00389 VSVS12_00390 VSVS12_00390 VSVS12_00390 416064 417704 + hypothetical protein gene gene389 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00390 VSVS12_00391 VSVS12_00391 VSVS12_00391 417701 418867 + hypothetical protein gene gene390 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00391 VSVS12_00392 VSVS12_00392 galE galE 418860 419810 + UDP-glucose 4-epimerase Involved in the metabolism of galactose. Catalyzes the conversion of UDP-galactose (UDP-Gal) to UDP-glucose (UDP-Glc) through a mechanism involving the transient reduction of NAD (By similarity)%3B Belongs to the NAD(P)-dependent epimerase/dehydratase family%3B KEGG: ret:RHE_CH02844 UDP-glucose 4-epimerase gene gene391 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00392 VSVS12_00393 VSVS12_00393 VSVS12_00393 419820 420368 + Undecaprenyl phosphate N%2CN'-diacetylbacillosamine 1-phosphate transferase Glycosyl-1-phosphate transferase that mediates the first step in the biosynthesis of the undecaprenyl-linked heptasaccharide donor in the N-linked protein glycosylation pathway. Catalyzes the linking of uridine 5'- diphosphobacillosamine (UDP-Bac) to undecaprenyl phosphate to create the first membrane-associated intermediate undecaprenylpyrophosphate-linked Bac (Und-PP-Bac)%3B Belongs to the bacterial sugar transferase family gene gene392 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00393 VSVS12_00394 VSVS12_00394 VSVS12_00394 420778 422715 + Capsular polysaccharide biosynthesis protein CapD Required for the biosynthesis of type 1 capsular polysaccharide. Belongs to the polysaccharide synthase family gene gene393 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00394 VSVS12_00395 VSVS12_00395 VSVS12_00395 422808 423815 + UDP-glucose 4-epimerase Involved in the metabolism of galactose. Catalyzes the conversion of UDP-galactose (UDP-Gal) to UDP-glucose (UDP-Glc) through a mechanism involving the transient reduction of NAD (By similarity)%3B Belongs to the NAD(P)-dependent epimerase/dehydratase family%3B KEGG: eco:b0759 UDP-glucose 4-epimerase gene gene394 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00395 VSVS12_00396 VSVS12_00396 VSVS12_00396 423968 424585 - hypothetical protein gene gene395 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00396 VSVS12_00397 VSVS12_00397 VSVS12_00397 424582 425745 - hypothetical protein gene gene396 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00397 VSVS12_00398 VSVS12_00398 VSVS12_00398 426053 427396 - hypothetical protein gene gene397 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00398 VSVS12_00399 VSVS12_00399 VSVS12_00399 427464 430544 - hypothetical protein gene gene398 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00399 VSVS12_00400 VSVS12_00400 VSVS12_00400 430534 432153 - hypothetical protein gene gene399 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00400 VSVS12_00401 VSVS12_00401 VSVS12_00401 432572 433126 + hypothetical protein gene gene400 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00401 VSVS12_00402 VSVS12_00402 VSVS12_00402 433431 433553 - hypothetical protein gene gene401 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00402 VSVS12_00403 VSVS12_00403 VSVS12_00403 434469 434993 + hypothetical protein gene gene402 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00403 VSVS12_00404 VSVS12_00404 VSVS12_00404 435045 437702 + hypothetical protein gene gene403 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00404 VSVS12_00405 VSVS12_00405 VSVS12_00405 437825 438829 + hypothetical protein gene gene404 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00405 VSVS12_00406 VSVS12_00406 VSVS12_00406 439152 441359 - putative lipoprotein GfcD gene gene405 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00406 VSVS12_00407 VSVS12_00407 VSVS12_00407 441356 442135 - uncharacterized protein To E. coli YmcB gene gene406 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00407 VSVS12_00408 VSVS12_00408 VSVS12_00408 442142 442804 - putative lipoprotein YjbF To E. coli YmcC gene gene407 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00408 VSVS12_00409 VSVS12_00409 VSVS12_00409 442899 443141 - hypothetical protein gene gene408 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00409 VSVS12_00410 VSVS12_00410 hslV hslV 443456 443998 + HslU--HslV peptidase Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery%3B Belongs to the peptidase T1B family. HslV subfamily%3B KEGG: eco:b3932 ATP-dependent HslUV protease%2C peptidase subunit HslV gene gene409 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00410 VSVS12_00411 VSVS12_00411 VSVS12_00411 444037 445380 + ATP-dependent protease ATPase subunit HslU ATPase subunit of a proteasome-like degradation comple%3B this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis%3B Belongs to the ClpX chaperone family. HslU subfamily gene gene410 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00411 VSVS12_00412 VSVS12_00412 VSVS12_00412 445548 445925 - Fumarate reductase subunit Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane%3B Belongs to the FrdD family gene gene411 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00412 VSVS12_00413 VSVS12_00413 VSVS12_00413 445937 446320 - Fumarate reductase subunit Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane%3B Belongs to the FrdC family gene gene412 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00413 VSVS12_00414 VSVS12_00414 frdB frdB 446322 447080 - Fumarate reductase (quinol) Two distinct%2C membrane-bound%2C FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversio%3B the fumarate reductase is used in anaerobic growth%2C and the succinate dehydrogenase is used in aerobic growth%3B Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family%3B Contains 1 2Fe-2S ferredoxin-type domain%3B Contains 1 4Fe-4S ferredoxin-type domain%3B KEGG: vch:VC2657 fumarate reductase iron-sulfur subunit%3B overlaps another CDS with the same product name gene gene413 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00414 VSVS12_00415 VSVS12_00415 frdA frdA 447080 448897 - Fumarate reductase (quinol) Two distinct%2C membrane-bound%2C FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversio%3B the fumarate reductase is used in anaerobic growth%2C and the succinate dehydrogenase is used in aerobic growth. Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily%3B KEGG: vvu:VV1_1269 fumarate reductase flavoprotein subunit%3B overlaps another CDS with the same product name gene gene414 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00415 VSVS12_00416 VSVS12_00416 VSVS12_00416 449135 449245 + hypothetical protein gene gene415 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00416 VSVS12_00417 VSVS12_00417 poxA poxA 449324 450346 + Lysine--tRNA ligase With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB%2C forming a lysyl-adenylate%2C from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P%3B Belongs to the class-II aminoacyl-tRNA synthetase family. EpmA subfamily%3B KEGG: hdu:HD0029 lysyl-tRNA synthetase%2C class II gene gene416 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00417 VSVS12_00418 VSVS12_00418 VSVS12_00418 450384 451853 - hypothetical protein gene gene417 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00418 VSVS12_00419 VSVS12_00419 VSVS12_00419 452224 452658 + Thiosulfate sulfurtransferase Contains 1 rhodanese domain%3B KEGG: mham:J450_03580 thiosulfate sulfurtransferase gene gene418 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00419 VSVS12_00420 VSVS12_00420 VSVS12_00420 452807 453277 + Protein-export protein SecB One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins%2C maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA%3B Belongs to the SecB family gene gene419 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00420 VSVS12_00421 VSVS12_00421 gpsA gpsA 453438 454472 + Glycerol-3-phosphate dehydrogenase (NAD(P)(+)) Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family%3B KEGG: vcy:IX92_15030 glycerol-3-phosphate dehydrogenase (NAD(P)+) gene gene420 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00421 VSVS12_00422 VSVS12_00422 cysE cysE 454510 455331 + Serine O-acetyltransferase Belongs to the transferase hexapeptide repeat family%3B KEGG: mvr:X781_3590 serine O-acetyltransferase gene gene421 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00422 VSVS12_00423 VSVS12_00423 VSVS12_00423 455422 455961 - Negative transcription regulator PadR Negative transcriptional regulator of padC phenolic acid decarboxylase gene gene422 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00423 VSVS12_00424 VSVS12_00424 VSVS12_00424 456405 459038 - Phosphoenolpyruvate carboxylase Forms oxaloacetate%2C a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle%3B Belongs to the PEPCase type 1 family%3B KEGG: kmi:VW41_00490 phosphoenolpyruvate carboxylase gene gene423 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00424 VSVS12_00425 VSVS12_00425 argE argE 459357 460496 - Acetylornithine deacetylase Belongs to the peptidase M20A family. ArgE subfamily%3B KEGG: pae:PA5206 acetylornithine deacetylase gene gene424 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00425 VSVS12_00426 VSVS12_00426 argC argC 460648 461649 + N-acetyl-gamma-glutamyl-phosphate reductase Belongs to the NAGSA dehydrogenase family. Type 1 subfamily%3B KEGG: vch:VC2644 N-acetyl-gamma-glutamyl-phosphate reductase gene gene425 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00426 VSVS12_00427 VSVS12_00427 argB argB 461668 462462 + Acetylglutamate kinase Belongs to the acetylglutamate kinase family%3B KEGG: vcy:IX92_14215 acetylglutamate kinase gene gene426 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00427 VSVS12_00428 VSVS12_00428 argG argG 462518 463732 + Argininosuccinate synthase Belongs to the argininosuccinate synthase family. Type 1 subfamily%3B KEGG: vvu:VV1_1373 argininosuccinate synthase gene gene427 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00428 VSVS12_00429 VSVS12_00429 argH argH 463863 465236 + Argininosuccinate lyase In the N-terminal sectio%3B belongs to the lyase 1 family. Argininosuccinate lyase subfamily%3B In the C-terminal sectio%3B belongs to the acetyltransferase family. ArgA subfamily%3B Contains 1 N-acetyltransferase domain%3B KEGG: eco:b3960 argininosuccinate lyase gene gene428 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00429 VSVS12_00430 VSVS12_00430 pdhD pdhD 466238 467725 - Dihydrolipoyl dehydrogenase Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family%3B KEGG: van:VAA_02624 dihydrolipoamide dehydrogenase gene gene429 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00430 VSVS12_00431 VSVS12_00431 VSVS12_00431 467938 468666 - Glutathione amide-dependent peroxidase Catalyzes the oxidation of glutathione amide (GASH) to produce glutathione amide disulfide (GASSAG). May play a role in GASH metabolism under anaerobic conditions as a sulfide carrier necessary for cytoplasmic sulfide oxidation%3B Contains 1 glutaredoxin domain%3B Contains 1 thioredoxin domain%3B KEGG: vfi:VF_2300 peroxiredoxin%3B Peroxidases gene gene430 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00431 VSVS12_00432 VSVS12_00432 VSVS12_00432 468837 469724 + Hydrogen peroxide-inducible protein activator Required for the induction of a regulon of hydrogen peroxide inducible genes such as catalase and glutathione- reductase%3B Contains 1 HTH lysR-type DNA-binding domain gene gene431 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00432 VSVS12_00433 VSVS12_00433 VSVS12_00433 469751 470944 - Transposase for insertion sequence element IS1001 Involved in the transposition of the insertion sequence. Belongs to the transposase 12 family gene gene432 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00433 VSVS12_00434 VSVS12_00434 VSVS12_00434 471048 472241 - Transposase for insertion sequence element IS1001 Involved in the transposition of the insertion sequence. Belongs to the transposase 12 family gene gene433 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00434 VSVS12_00435 VSVS12_00435 mrcA mrcA 472403 474904 - Penicillin-binding protein 1A Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits) (By similarity)%3B In the N-terminal sectio%3B belongs to the glycosyltransferase 51 family%3B In the C-terminal sectio%3B belongs to the transpeptidase family%3B KEGG: ddc:Dd586_3807 penicillin-binding protein 1A%3B Hexosyltransferases gene gene434 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00435 VSVS12_00436 VSVS12_00436 VSVS12_00436 475089 476030 + hypothetical protein gene gene435 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00436 VSVS12_00437 VSVS12_00437 VSVS12_00437 476050 476652 + hypothetical protein gene gene436 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00437 VSVS12_00438 VSVS12_00438 VSVS12_00438 476633 477235 + hypothetical protein gene gene437 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00438 VSVS12_00439 VSVS12_00439 VSVS12_00439 477225 477800 + hypothetical protein gene gene438 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00439 VSVS12_00440 VSVS12_00440 VSVS12_00440 477797 479515 + Fimbrial assembly protein PilQ Essential for the formation of pili. Involved in the biogenesis of type 4 fimbriae probably by serving as a 'porthole' allowing passage of the fimbrae through the outer membrane. Belongs to the GSP D family gene gene439 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00440 VSVS12_00441 VSVS12_00441 aroK aroK 479680 480198 + Shikimate kinase Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate%3B Belongs to the shikimate kinase family%3B KEGG: eco:b3390 shikimate kinase gene gene440 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00441 VSVS12_00442 VSVS12_00442 aroB aroB 480229 481332 + 3-dehydroquinate synthase Belongs to the dehydroquinate synthase family%3B KEGG: ksa:C813_17270 3-dehydroquinate synthase gene gene441 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00442 VSVS12_00443 VSVS12_00443 VSVS12_00443 481428 482900 + hypothetical protein gene gene442 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00443 VSVS12_00444 VSVS12_00444 VSVS12_00444 483025 483879 + Site-specific DNA-methyltransferase (adenine-specific) Methylates DNA within the sequence GATC and protects the DNA from cleavage by the restriction endonuclease MboI. Although it shares sequence specificity with a number of type II restriction endonucleases and methylases%2C it is thought to act in postreplication mismatch repair rather than as a part of a restriction modification system. May also play a role in DNA replication (By similarity)%3B Belongs to the N(4)/N(6)-methyltransferase family%3B KEGG: eco:b3387 DNA adenine methylase gene gene443 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00444 VSVS12_00445 VSVS12_00445 VSVS12_00445 483983 484654 + Ribulose-phosphate 3-epimerase Catalyzes the reversible epimerization of D-ribulose 5- phosphate to D-xylulose 5-phosphate%3B Belongs to the ribulose-phosphate 3-epimerase family%3B KEGG: eco:b3386 ribulose-phosphate 3-epimerase gene gene444 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00445 VSVS12_00446 VSVS12_00446 VSVS12_00446 484680 485360 + Phosphoglycolate phosphatase Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends%2C a major class of DNA lesions induced by oxidative stress%3B Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family%3B KEGG: sty:STY4314 phosphoglycolate phosphatase gene gene445 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00446 VSVS12_00447 VSVS12_00447 warS warS 485477 486493 + Tryptophan--tRNA ligase Belongs to the class-I aminoacyl-tRNA synthetase family%3B KEGG: buc:BU536 tryptophanyl-tRNA synthetase gene gene446 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00447 VSVS12_00448 VSVS12_00448 pabA pabA 486662 487240 + Aminodeoxychorismate synthase Part of a heterodimeric complex that catalyzes the two- step biosynthesis of 4-amino-4-deoxychorismate (ADC)%2C a precursor of p-aminobenzoate (PABA) and tetrahydrofolate. In the first step%2C a glutamine amidotransferase (PabA) generates ammonia as a substrate that%2C along with chorismate%2C is used in the second step%2C catalyzed by aminodeoxychorismate synthase (PabB) to produce ADC. PabA converts glutamine into glutamate only in the presence of stoichiometric amounts of PabB. Also involved in the biosynthesis of anthranilate%3B Contains 1 glutamine amidotransferase type-1 domain%3B KEGG: eco:b3360 para-aminobenzoate synthetase component II gene gene447 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00448 VSVS12_00449 VSVS12_00449 argD argD 487734 488948 + Acetylornithine transaminase Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily%3B KEGG: vtu:IX91_01070 acetylornithine/N-succinyldiaminopimelate aminotransferase gene gene448 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00449 VSVS12_00450 VSVS12_00450 astA astA 489009 490028 + Arginine N-succinyltransferase Catalyzes the transfer of succinyl-CoA to arginine to produce N(2)-succinylarginine%3B Belongs to the arginine N-succinyltransferase family%3B KEGG: vvu:VV1_1314 arginine N-succinyltransferase gene gene449 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00450 VSVS12_00451 VSVS12_00451 mmsA mmsA 490055 491512 + Malonate-semialdehyde dehydrogenase (acetylating) Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate%3B Belongs to the aldehyde dehydrogenase family. AstD subfamily%3B KEGG: spe:Spro_0606 malonate-semialdehyde dehydrogenase (acetylating) / methylmalonate-semialdehyde dehydrogenase gene gene450 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00451 VSVS12_00452 VSVS12_00452 VSVS12_00452 491623 492414 + hypothetical protein gene gene451 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00452 VSVS12_00453 VSVS12_00453 VSVS12_00453 492640 493272 - cAMP-activated global transcriptional regulator A global transcription regulator. Complexes with cyclic AMP (cAMP) which allosterically activates DNA binding to regulate transcription. It can act as an activator%2C repressor%2C coactivator or corepressor. Induces a severe bend in DNA. Acts as a negative regulator of its own synthesis as well as for adenylate cyclase (cyaA)%2C which generates cAMP. Plays a major role in carbon catabolite repression (CCR) (By similarity)%3B Contains 1 cyclic nucleotide-binding domain%3B Contains 1 HTH crp-type DNA-binding domain gene gene452 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00453 VSVS12_00454 VSVS12_00454 VSVS12_00454 493362 493562 + hypothetical protein gene gene453 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00454 VSVS12_00455 VSVS12_00455 prkB prkB 493516 494385 - Phosphoribulokinase Belongs to the phosphoribulokinase family%3B KEGG: eco:b3355 phosphoribulokinase gene gene454 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00455 VSVS12_00456 VSVS12_00456 VSVS12_00456 494580 494792 - UPF0270 protein Belongs to the UPF0270 family gene gene455 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00456 VSVS12_00457 VSVS12_00457 VSVS12_00457 494835 495809 - Putative esterase Belongs to the AB hydrolase superfamily. AB hydrolase 4 family gene gene456 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00457 VSVS12_00458 VSVS12_00458 VSVS12_00458 495815 496306 - hypothetical protein gene gene457 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00458 VSVS12_00459 VSVS12_00459 VSVS12_00459 496306 498225 - putative ABC transporter ATP-binding protein Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily%3B Contains 2 ABC transporter domains gene gene458 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00459 VSVS12_00460 VSVS12_00460 VSVS12_00460 498361 498969 + Glutathione-regulated potassium-efflux system ancillary protein KefG Regulatory subunit of a potassium efflux system that confers protection against electrophiles. Required for full activity of KefB%3B Belongs to the NAD(P)H dehydrogenase (quinone) family. KefG subfamily gene gene459 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00460 VSVS12_00461 VSVS12_00461 VSVS12_00461 498953 500749 + Glutathione-regulated potassium-efflux system protein KefB Pore-forming subunit of a potassium efflux system that confers protection against electrophiles. Catalyzes K(+)/H(+) antiport%3B Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2. A. 37) family. KefB subfamily%3B Contains 1 RCK N-terminal domain gene gene460 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00461 VSVS12_00462 VSVS12_00462 VSVS12_00462 500808 501002 + uncharacterized protein gene gene461 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00462 VSVS12_00463 VSVS12_00463 slyD slyD 501090 501668 + Peptidylprolyl isomerase Folding helper with both chaperone and peptidyl-prolyl cis-trans isomerase (PPIase) activities. Chaperone activity prevents aggregation of unfolded or partially folded proteins and promotes their correct folding. PPIases catalyze the cis-trans isomerization of Xaa-Pro bonds of peptides%2C which accelerates slow steps of protein folding and thus shortens the lifetime of intermediates. Both strategies lower the concentration of intermediates and increase the productivity and yield of the folding reaction%3B Also involved in hydrogenase metallocenter assembly%2C probably by participating in the nickel insertion step. This function in hydrogenase biosynthesis requires chaperone activity and the presence of the metal-binding domain%2C but not PPIase activity (By similarity)%3B Belongs to the FKBP-type PPIase family%3B Contains 1 PPIase FKBP-type domain%3B KEGG: rso:RSc1149 FKBP-type peptidyl-prolyl cis-trans isomerase SlyD gene gene462 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00463 VSVS12_00464 VSVS12_00464 iaaA iaaA 501801 502742 + Beta-aspartyl-peptidase Has both L-asparaginase and beta-aspartyl peptidase activity. Does not have aspartylglucosaminidase activity and is inactive toward GlcNAc-L-Asn. Likewise%2C has no activity toward glutamine (By similarity)%3B Belongs to the Ntn-hydrolases family%3B KEGG: vch:VC2603 beta-aspartyl-peptidase (threonine type) gene gene463 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00464 VSVS12_00465 VSVS12_00465 purA purA 502880 504196 + Adenylosuccinate synthase Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP%3B Belongs to the adenylosuccinate synthetase family%3B KEGG: eco:b4177 adenylosuccinate synthase gene gene464 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00465 VSVS12_00466 VSVS12_00466 VSVS12_00466 504472 505167 + Sodium-type polar flagellar protein MotX The power to drive the polar flagellar rotary motor of V. parahaemolyticus is derived from the transmembrane potential of sodium ions. Force is generated by the motor on coupling of the movement of ions across the membrane to rotation of the flagellum. MotX interacts with MotY%2C which is the presumed stationary component of the motor. MotX may form a sodium channel. Contains 3 Sel1-like repeats gene gene465 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00466 VSVS12_00467 VSVS12_00467 mtaD mtaD 505262 506665 - S-methyl-5'-thioadenosine deaminase Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine%2C respectively. Is also able to deaminate adenosine%3B Belongs to the MTA/SAH deaminase family%3B KEGG: dpr:Despr_0311 5-methylthioadenosine/S-adenosylhomocysteine deaminase gene gene466 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00467 VSVS12_00468 VSVS12_00468 vacB vacB 507012 509480 + Ribonuclease 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs%3B Belongs to the RNR ribonuclease family. RNase R subfamily%3B Contains 1 S1 motif domain%3B KEGG: vpa:VP2807 ribonuclease R%3B Acting on ester bonds gene gene467 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00468 VSVS12_00469 VSVS12_00469 rlmB rlmB 509505 510242 + 23S rRNA (guanosine(2251)-2'-O)-methyltransferase Specifically methylates the ribose of guanosine 2251 in 23S rRNA%3B Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. RlmB subfamily%3B KEGG: vvu:VV1_1305 23S rRNA (guanosine2251-2'-O)-methyltransferase gene gene468 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00469 VSVS12_00470 VSVS12_00470 VSVS12_00470 510837 511148 + 30S ribosomal protein S10 Involved in the binding of tRNA to the ribosomes%3B Belongs to the ribosomal protein S10P family gene gene469 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00470 VSVS12_00471 VSVS12_00471 VSVS12_00471 511163 511792 + 50S ribosomal protein L3 One of the primary rRNA binding proteins%2C it binds directly near the 3'-end of the 23S rRNA%2C where it nucleates assembly of the 50S subunit%3B Belongs to the ribosomal protein L3P family gene gene470 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00471 VSVS12_00472 VSVS12_00472 VSVS12_00472 511810 512412 + 50S ribosomal protein L4 One of the primary rRNA binding proteins%2C this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome%3B Forms part of the polypeptide exit tunnel%3B Belongs to the ribosomal protein L4P family gene gene471 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00472 VSVS12_00473 VSVS12_00473 VSVS12_00473 512409 512711 + 50S ribosomal protein L23 One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome%3B Belongs to the ribosomal protein L23P family gene gene472 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00473 VSVS12_00474 VSVS12_00474 VSVS12_00474 512728 513552 + 50S ribosomal protein L2 One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome%2C for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activit%3B this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome%3B Belongs to the ribosomal protein L2P family gene gene473 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00474 VSVS12_00475 VSVS12_00475 VSVS12_00475 513572 513850 + 30S ribosomal protein S19%2C chloroplastic Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA%3B Belongs to the ribosomal protein S19P family gene gene474 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00475 VSVS12_00476 VSVS12_00476 VSVS12_00476 513861 514193 + 50S ribosomal protein L22 This protein binds specifically to 23S rRN%3B its binding is stimulated by other ribosomal proteins%2C e. g. L4%2C L17%2C and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)%3B The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit%2C while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome%3B Belongs to the ribosomal protein L22P family gene gene475 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00476 VSVS12_00477 VSVS12_00477 VSVS12_00477 514213 514911 + 30S ribosomal protein S3 Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome%2C positioning it for translation%3B Belongs to the ribosomal protein S3P family%3B Contains 1 KH type-2 domain gene gene476 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00477 VSVS12_00478 VSVS12_00478 VSVS12_00478 514923 515333 + 50S ribosomal protein L16 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs%3B Belongs to the ribosomal protein L16P family gene gene477 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00478 VSVS12_00479 VSVS12_00479 VSVS12_00479 515333 515524 + 50S ribosomal protein L29 Belongs to the ribosomal protein L29P family gene gene478 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00479 VSVS12_00480 VSVS12_00480 VSVS12_00480 515524 515778 + 30S ribosomal protein S17 One of the primary rRNA binding proteins%2C it binds specifically to the 5'-end of 16S ribosomal RNA%3B Belongs to the ribosomal protein S17P family gene gene479 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00480 VSVS12_00481 VSVS12_00481 VSVS12_00481 515944 516315 + 50S ribosomal protein L14 Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome%3B Belongs to the ribosomal protein L14P family gene gene480 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00481 VSVS12_00482 VSVS12_00482 VSVS12_00482 516327 516641 + 50S ribosomal protein L24 One of two assembly initiator proteins%2C it binds directly to the 5'-end of the 23S rRNA%2C where it nucleates assembly of the 50S subunit%3B One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit%3B Belongs to the ribosomal protein L24P family gene gene481 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00482 VSVS12_00483 VSVS12_00483 VSVS12_00483 516656 517195 + 50S ribosomal protein L5 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit%2C where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b)%2C connecting the 2 subunit%3B this bridge is implicated in subunit movement. Contacts the P site tRN%3B the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs%3B Belongs to the ribosomal protein L5P family gene gene482 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00483 VSVS12_00484 VSVS12_00484 VSVS12_00484 517213 517518 + 30S ribosomal protein S14 Binds 16S rRNA%2C required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site%3B Belongs to the ribosomal protein S14P family gene gene483 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00484 VSVS12_00485 VSVS12_00485 VSVS12_00485 517548 517940 + 30S ribosomal protein S8 One of the primary rRNA binding proteins%2C it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit%3B Belongs to the ribosomal protein S8P family gene gene484 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00485 VSVS12_00486 VSVS12_00486 VSVS12_00486 517951 518484 + 50S ribosomal protein L6 This protein binds to the 23S rRNA%2C and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk%2C and near the tRNA binding site of the peptidyltransferase center%3B Belongs to the ribosomal protein L6P family gene gene485 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00486 VSVS12_00487 VSVS12_00487 VSVS12_00487 518494 518847 + 50S ribosomal protein L18 This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit%2C where it forms part of the central protuberance%3B Belongs to the ribosomal protein L18P family gene gene486 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00487 VSVS12_00488 VSVS12_00488 VSVS12_00488 518862 519365 + 30S ribosomal protein With S4 and S12 plays an important role in translational accuracy%3B Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body%3B Belongs to the ribosomal protein S5P family%3B Contains 1 S5 DRBM domain gene gene487 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00488 VSVS12_00489 VSVS12_00489 VSVS12_00489 519373 519549 + 50S ribosomal protein L30 Belongs to the ribosomal protein L30P family gene gene488 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00489 VSVS12_00490 VSVS12_00490 VSVS12_00490 519556 519990 + 50S ribosomal protein L15 Binds to the 23S rRNA%3B Belongs to the ribosomal protein L15P family gene gene489 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00490 VSVS12_00491 VSVS12_00491 VSVS12_00491 520011 521345 + Protein translocase subunit SecY The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7%2C and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently%3B Belongs to the SecY/SEC61-alpha family gene gene490 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00491 VSVS12_00492 VSVS12_00492 VSVS12_00492 521385 521498 + 50S ribosomal protein L36%2C chloroplastic Belongs to the ribosomal protein L36P family gene gene491 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00492 VSVS12_00493 VSVS12_00493 VSVS12_00493 521647 522003 + Cyanelle 30S ribosomal protein S13 Located at the top of the head of the 30S subunit%2C it contacts several helices of the 16S rRNA%3B Belongs to the ribosomal protein S13P family gene gene492 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00493 VSVS12_00494 VSVS12_00494 VSVS12_00494 522022 522411 + 30S ribosomal protein S11 Located on the platform of the 30S subunit%2C it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome%3B Belongs to the ribosomal protein S11P family gene gene493 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00494 VSVS12_00495 VSVS12_00495 VSVS12_00495 522439 523059 + 30S ribosomal protein S4 One of the primary rRNA binding proteins%2C it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit%3B With S5 and S12 plays an important role in translational accuracy%3B Belongs to the ribosomal protein S4P family%3B Contains 1 S4 RNA-binding domain gene gene494 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00495 VSVS12_00496 VSVS12_00496 rpoA rpoA 523084 524076 + DNA-directed RNA polymerase DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates%3B Belongs to the RNA polymerase alpha chain family%3B KEGG: eco:b3295 DNA-directed RNA polymerase subunit alpha gene gene495 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00496 VSVS12_00497 VSVS12_00497 VSVS12_00497 524103 524483 + 50S ribosomal protein L17 Belongs to the ribosomal protein L17P family gene gene496 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00497 VSVS12_00498 VSVS12_00498 VSVS12_00498 524583 525068 - hypothetical protein gene gene497 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00498 VSVS12_00499 VSVS12_00499 fklB fklB 525162 525782 - Peptidylprolyl isomerase PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Belongs to the FKBP-type PPIase family%3B Contains 1 PPIase FKBP-type domain%3B KEGG: vch:VC2568 FKBP-type peptidyl-prolyl cis-trans isomerase FklB gene gene498 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00499 VSVS12_00500 VSVS12_00500 VSVS12_00500 526014 526574 + uncharacterized protein gene gene499 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00500 VSVS12_00501 VSVS12_00501 VSVS12_00501 526601 527461 - S-adenosylmethionine uptake transporter Transports S-adenosylmethionine%3B Belongs to the drug/metabolite transporter (DMT) superfamily. 10 TMS drug/metabolite exporter (DME) (TC 2. A. 7. 3) family%3B Contains 2 EamA domains gene gene500 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00501 VSVS12_00502 VSVS12_00502 VSVS12_00502 527461 527931 - UPF0039 protein Belongs to the UPF0039 (ElaA) family%3B Contains 1 N-acetyltransferase domain gene gene501 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00502 VSVS12_00503 VSVS12_00503 VSVS12_00503 528066 528629 - hypothetical protein gene gene502 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00503 VSVS12_00504 VSVS12_00504 cpdB cpdB 528738 530789 - 2'%2C3'-cyclic-nucleotide 2'-phosphodiesterase This bifunctional enzyme catalyzes two consecutive reactions during ribonucleic acid degradation. Converts a 2'%2C3'- cyclic nucleotide to a 3'-nucleotide and then the 3'-nucleotide to the corresponding nucleoside and phosphate%3B Belongs to the 5'-nucleotidase family%3B KEGG: vvu:VV1_0728 2'%2C3'-cyclic-nucleotide 2'-phosphodiesterase / 3'-nucleotidase gene gene503 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00504 VSVS12_00505 VSVS12_00505 cobA cobA 530961 531827 + Uroporphyrinogen-III C-methyltransferase Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally%2C it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme%3B In the N-terminal sectio%3B belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family%3B In the C-terminal sectio%3B belongs to the precorrin methyltransferase family%3B KEGG: vcy:IX92_14505 uroporphyrin-III C-methyltransferase gene gene504 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00505 VSVS12_00506 VSVS12_00506 cysD cysD 531875 532783 + Sulfate adenylyltransferase Belongs to the PAPS reductase family. CysD subfamily%3B KEGG: eta:ETA_27060 sulfate adenylyltransferase subunit 2 gene gene505 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00506 VSVS12_00507 VSVS12_00507 cysN cysN 532804 534231 + Sulfate adenylyltransferase May be the GTPase%2C regulating ATP sulfurylase activity%3B Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily%3B Contains 1 tr-type G (guanine nucleotide-binding) domain%3B KEGG: vvu:VV1_0725 sulfate adenylyltransferase subunit 1 gene gene506 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00507 VSVS12_00508 VSVS12_00508 VSVS12_00508 534406 536130 + Putative sulfur deprivation response regulator Not know%3B mutations in SAC1 produces cells that cannot synthesize arylsulfatase and cannot take up sulfate as rapidly as wild-type cells. SAC1 is necessary for cells to survive sulfur deprivation. Belongs to the CitM (TC 2. A. 11) transporter family%3B Contains 2 RCK C-terminal domains gene gene507 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00508 VSVS12_00509 VSVS12_00509 cysC cysC 536142 536759 + Adenylyl-sulfate kinase Catalyzes the synthesis of activated sulfate. Belongs to the APS kinase family%3B KEGG: rah:Rahaq_0678 adenylylsulfate kinase gene gene508 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00509 VSVS12_00510 VSVS12_00510 VSVS12_00510 536918 537379 - hypothetical protein gene gene509 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00510 VSVS12_00511 VSVS12_00511 VSVS12_00511 537397 537855 - Zinc uptake regulation protein Acts as a negative controlling element%2C employing Zn(2+) as a cofactor to bind the operator of the repressed genes (znuACB). Belongs to the Fur family gene gene510 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00511 VSVS12_00512 VSVS12_00512 dusA dusA 538114 539094 + tRNA-dihydrouridine(20/20a) synthase Catalyzes the synthesis of 5%2C6-dihydrouridine (D)%2C a modified base found in the D-loop of most tRNAs%2C via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U20 and U20a in tRNAs%3B Belongs to the Dus family. DusA subfamily%3B KEGG: vch:VC0379 tRNA-dihydrouridine synthase A%3B Oxidoreductases gene gene511 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00512 VSVS12_00513 VSVS12_00513 VSVS12_00513 539255 539464 + Phage shock protein Effector of the phage shock response gene gene512 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00513 VSVS12_00514 VSVS12_00514 VSVS12_00514 539537 540199 + hypothetical protein gene gene513 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00514 VSVS12_00515 VSVS12_00515 VSVS12_00515 540350 540577 + hypothetical protein gene gene514 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00515 VSVS12_00516 VSVS12_00516 cysJ cysJ 540698 542548 + Assimilatory sulfite reductase (NADPH) Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH -> FAD -> FMN to the hemoprotein component%3B Contains 1 FAD-binding FR-type domain%3B Contains 1 flavodoxin-like domain%3B KEGG: van:VAA_00271 sulfite reductase (NADPH) flavoprotein alpha-component%3B overlaps another CDS with the same product name gene gene515 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00516 VSVS12_00517 VSVS12_00517 cysI cysI 542548 544272 + Assimilatory sulfite reductase (NADPH) Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate%3B Belongs to the nitrite and sulfite reductase 4Fe-4S domain family%3B KEGG: vha:VIBHAR_00004 sulfite reductase (NADPH) hemoprotein beta-component%3B overlaps another CDS with the same product name gene gene516 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00517 VSVS12_00518 VSVS12_00518 cysH cysH 544265 545041 + Phosphoadenylyl-sulfate reductase (thioredoxin) Reduction of activated sulfate into sulfite. Belongs to the PAPS reductase family. CysH subfamily%3B KEGG: xne:XNC1_3858 phosphoadenosine phosphosulfate reductase gene gene517 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00518 VSVS12_00519 VSVS12_00519 VSVS12_00519 545696 547242 + 16S ribosomal RNA rRNA gene518 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00519 VSVS12_00520 VSVS12_00520 VSVS12_00520 547540 550433 + 23S ribosomal RNA rRNA gene519 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00520 VSVS12_00521 VSVS12_00521 VSVS12_00521 550547 550662 + 5S ribosomal RNA rRNA gene520 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00521 VSVS12_00522 VSVS12_00522 VSVS12_00522 551056 552602 + 16S ribosomal RNA rRNA gene521 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00522 VSVS12_00523 VSVS12_00523 VSVS12_00523 552672 552747 + tRNA-Glu tRNA gene522 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00523 VSVS12_00524 VSVS12_00524 VSVS12_00524 553039 555932 + 23S ribosomal RNA rRNA gene523 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00524 VSVS12_00525 VSVS12_00525 VSVS12_00525 556023 556138 + 5S ribosomal RNA rRNA gene524 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00525 VSVS12_00526 VSVS12_00526 VSVS12_00526 556515 558061 + 16S ribosomal RNA rRNA gene525 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00526 VSVS12_00527 VSVS12_00527 VSVS12_00527 558359 561252 + 23S ribosomal RNA rRNA gene526 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00527 VSVS12_00528 VSVS12_00528 VSVS12_00528 561366 561481 + 5S ribosomal RNA rRNA gene527 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00528 VSVS12_00529 VSVS12_00529 VSVS12_00529 561552 561628 + tRNA-Asp tRNA gene528 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00529 VSVS12_00530 VSVS12_00530 VSVS12_00530 562392 562790 + hypothetical protein gene gene529 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00530 VSVS12_00531 VSVS12_00531 VSVS12_00531 562821 563519 + Inner membrane protein Belongs to the DedA family gene gene530 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00531 VSVS12_00532 VSVS12_00532 VSVS12_00532 563635 564918 - Na(+)/H(+) antiporter NhaP Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons. Has also weak Li(+)/H(+) antiport activity%3B Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2. A. 36) family gene gene531 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00532 VSVS12_00533 VSVS12_00533 metH metH 565088 568765 + Methionine synthase Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine%2C yielding enzyme-bound cob(I)alamin and methionine. Subsequently%2C remethylates the cofactor using methyltetrahydrofolate (By similarity)%3B Belongs to the vitamin-B12 dependent methionine synthase family%3B Contains 1 AdoMet activation domain%3B Contains 1 B12-binding domain%3B Contains 1 B12-binding N-terminal domain%3B Contains 1 Hcy-binding domain%3B Contains 1 pterin-binding domain%3B KEGG: vpa:VP2717 5-methyltetrahydrofolate--homocysteine methyltransferase gene gene532 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00533 VSVS12_00534 VSVS12_00534 VSVS12_00534 568848 570203 - Magnesium transporter MgtE Acts as a magnesium transporter%3B Belongs to the SLC41A transporter family%3B Contains 2 CBS domains gene gene533 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00534 VSVS12_00535 VSVS12_00535 VSVS12_00535 570342 570620 - Phosphocarrier protein NPr Component of the phosphoenolpyruvate-dependent nitrogen- metabolic phosphotransferase system (nitrogen-metabolic PTS)%2C that seems to be involved in regulating nitrogen metabolism. The phosphoryl group from phosphoenolpyruvate (PEP) is transferred to the phosphoryl carrier protein NPr by enzyme I-Ntr. Phospho-NPr then transfers it to EIIA-Ntr. Could function in the transcriptional regulation of sigma-54 dependent operons in conjunction with the NPr (PtsO) and EIIA-Ntr (PtsN) proteins (By similarity)%3B Belongs to the HPr family%3B Contains 1 HPr domain gene gene534 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00535 VSVS12_00536 VSVS12_00536 VSVS12_00536 570624 571487 - RNase adapter protein RapZ Modulates the synthesis of GlmS%2C by affecting the processing and stability of the regulatory small RNA GlmZ. When glucosamine-6-phosphate (GlcN6P) concentrations are high in the cell%2C RapZ binds GlmZ and targets it to cleavage by RNase E. Consequently%2C GlmZ is inactivated and unable to activate GlmS synthesis. Under low GlcN6P concentrations%2C RapZ is sequestered and inactivated by an other regulatory small RNA%2C GlmY%2C preventing GlmZ degradation and leading to synthesis of GlmS%3B Belongs to the RapZ-like family. RapZ subfamily gene gene535 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00536 VSVS12_00537 VSVS12_00537 ptsN ptsN 571496 571942 - Protein-N(pi)-phosphohistidine--sugar phosphotransferase Seems to have a role in regulating nitrogen assimilation%3B Contains 1 PTS EIIA type-2 domain%3B KEGG: pmr:PMI3646 PTS system%2C nitrogen regulatory IIA component gene gene536 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00537 VSVS12_00538 VSVS12_00538 VSVS12_00538 571945 572232 - Ribosome hibernation promoting factor During stationary phase%2C promotes and stabilizes dimerization of 70S ribosomes%2C leading to the formation of inactive 100S ribosomes%3B Belongs to the Hpf/RaiA ribosome-associated protein family. Hpf subfamily gene gene537 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00538 VSVS12_00539 VSVS12_00539 VSVS12_00539 572257 573717 - RNA polymerase sigma-54 factor Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is responsible for the expression of the nitrogen fixation genes. The open complex (sigma-54 and core RNA polymerase) serves as the receptor for receipt of the melting signal from the remotely bound activator protein NifA for the expression of the nitrogen fixation proteins. Belongs to the sigma-54 factor family gene gene538 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00539 VSVS12_00540 VSVS12_00540 lptB lptB 573761 574486 - Lipopolysaccharide export system ATP-binding protein LptB Part of the ABC transporter complex LptBFG involved in the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane. Probably responsible for energy coupling to the transport system (By similarity)%3B Belongs to the ABC transporter superfamily. Outer membrane lipopolysaccharide export (TC 1. B. 42) family%3B Contains 1 ABC transporter domain%3B KEGG: vch:VC2528 lipopolysaccharide export system ATP-binding protein%3B Acting on acid anhydrides%3B catalyzing transmembrane movement of substances gene gene539 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00540 VSVS12_00541 VSVS12_00541 VSVS12_00541 574489 574986 - Lipopolysaccharide export system protein LptA Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane%2C via interactions with LptC and LptD%2C thereby facilitating LPS transfer across the periplasm%3B Belongs to the LptA family gene gene540 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00541 VSVS12_00542 VSVS12_00542 VSVS12_00542 574967 575530 - hypothetical protein gene gene541 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00542 VSVS12_00543 VSVS12_00543 kdsC kdsC 575527 576084 - 3-deoxy-manno-octulosonate-8-phosphatase Catalyzes the activation of N-acetylneuraminic acid (NeuNAc) to cytidine 5'-monophosphate N-acetylneuraminic acid (CMP-NeuNAc)%2C a substrate required for the addition of sialic acid. Has some activity toward NeuNAc%2C N-glycolylneuraminic acid (Neu5Gc) or 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN) (By similarity)%3B Belongs to the CMP-NeuNAc synthase family%3B KEGG: pge:LG71_01200 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase (KDO 8-P phosphatase) gene gene542 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00543 VSVS12_00544 VSVS12_00544 kdsD kdsD 576084 577049 - Arabinose-5-phosphate isomerase Belongs to the SIS family. GutQ/KpsF subfamily%3B Contains 2 CBS domains%3B Contains 1 SIS domain%3B KEGG: vcy:IX92_01075 arabinose-5-phosphate isomerase gene gene543 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00544 VSVS12_00545 VSVS12_00545 VSVS12_00545 577069 578034 - Inner membrane protein Belongs to the sodium/potassium/calcium exchanger family gene gene544 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00545 VSVS12_00546 VSVS12_00546 VSVS12_00546 578228 579067 + Zinc import ATP-binding protein ZnuC Part of the ABC transporter complex ZnuABC involved in zinc import. Responsible for energy coupling to the transport system%3B Belongs to the ABC transporter superfamily. Zinc importer (TC 3. A. 1. 15. 5) family%3B Contains 1 ABC transporter domain gene gene545 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00546 VSVS12_00547 VSVS12_00547 VSVS12_00547 579064 579855 + putative phospholipid ABC transporter permease protein MlaE Part of the ABC transporter complex MlaFEDB that actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane (By similarity)%3B Belongs to the MlaE permease family gene gene546 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00547 VSVS12_00548 VSVS12_00548 VSVS12_00548 579858 580346 + putative phospholipid ABC transporter-binding protein MlaD Part of the ABC transporter complex MlaFEDB that actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane (By similarity)%3B Belongs to the MlaD family gene gene547 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00548 VSVS12_00549 VSVS12_00549 VSVS12_00549 580346 580984 + putative phospholipid-binding protein MlaC Actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane. May transfer phospholipid across the periplasmic space and deliver it to the MlaFEDB complex at the inner membrane%3B Belongs to the MlaC/ttg2D family gene gene548 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00549 VSVS12_00550 VSVS12_00550 VSVS12_00550 580981 581295 + hypothetical protein gene gene549 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00550 VSVS12_00551 VSVS12_00551 VSVS12_00551 581305 581559 + Acid stress protein IbaG Involved in cell resistance against acid stress%3B Belongs to the BolA/IbaG family gene gene550 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00551 VSVS12_00552 VSVS12_00552 murA murA 581569 582834 + UDP-N-acetylglucosamine 1-carboxyvinyltransferase Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine%3B Belongs to the EPSP synthase family. MurA subfamily%3B KEGG: vtu:IX91_01635 UDP-N-acetylglucosamine 1-carboxyvinyltransferase gene gene551 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00552 VSVS12_00553 VSVS12_00553 plsC plsC 582966 583694 + 1-acylglycerol-3-phosphate O-acyltransferase Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the 2 position. This enzyme can utilize either acyl-CoA or acyl-ACP as the fatty acyl donor%3B Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family%3B KEGG: amc:MADE_1016010 1-acyl-sn-glycerol-3-phosphate acyltransferase gene gene552 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00553 VSVS12_00554 VSVS12_00554 nylB nylB 583832 584875 + 6-aminohexanoate-oligomer exohydrolase KEGG: rde:RD1_3903 6-aminohexanoate-oligomer exohydrolase gene gene553 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00554 VSVS12_00555 VSVS12_00555 VSVS12_00555 584966 585041 - tRNA-Asn tRNA gene554 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00555 VSVS12_00556 VSVS12_00556 VSVS12_00556 585047 585122 - tRNA-Thr tRNA gene555 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00556 VSVS12_00557 VSVS12_00557 VSVS12_00557 585161 585236 - tRNA-Asn tRNA gene556 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00557 VSVS12_00558 VSVS12_00558 VSVS12_00558 585258 585333 - tRNA-Thr tRNA gene557 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00558 VSVS12_00559 VSVS12_00559 VSVS12_00559 585385 585460 - tRNA-Phe tRNA gene558 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00559 VSVS12_00560 VSVS12_00560 VSVS12_00560 585682 587307 - Heme-based aerotactic transducer HemAT Heme-containing signal transducer responsible for aerotaxis%2C the migratory response toward or away from oxygen%3B Contains 1 methyl-accepting transducer domain gene gene559 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00560 VSVS12_00561 VSVS12_00561 VSVS12_00561 587813 587888 - tRNA-Asn tRNA gene560 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00561 VSVS12_00562 VSVS12_00562 VSVS12_00562 587928 588003 - tRNA-Phe tRNA gene561 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00562 VSVS12_00563 VSVS12_00563 VSVS12_00563 588011 588086 - tRNA-Thr tRNA gene562 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00563 VSVS12_00564 VSVS12_00564 VSVS12_00564 588140 588215 - tRNA-Phe tRNA gene563 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00564 VSVS12_00565 VSVS12_00565 VSVS12_00565 588318 589454 - Membrane-bound lytic murein transglycosylase Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division%3B Belongs to the transglycosylase Slt family gene gene564 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00565 VSVS12_00566 VSVS12_00566 mutY mutY 589529 589801 - putative Fe(2+)-trafficking protein Could be a mediator in iron transactions between iron acquisition and iron-requiring processes%2C such as synthesis and/or repair of Fe-S clusters in biosynthetic enzymes%3B Belongs to the Fe(2+)-trafficking protein family%3B KEGG: baj:BCTU_372 A/G-specific adenine glycosylase%3B Hydrolyzing N-glycosyl compounds gene gene565 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00566 VSVS12_00567 VSVS12_00567 VSVS12_00567 589818 590870 - A/G-specific adenine glycosylase Adenine glycosylase active on G-A mispairs. MutY also corrects error-prone DNA synthesis past GO lesions which are due to the oxidatively damaged form of guanine: 7%2C8-dihydro-8- oxoguanine (8-oxo-dGTP). Belongs to the Nth/MutY family%3B KEGG: dji:CH75_15390 A/G-specific adenine glycosylase%3B Hydrolyzing N-glycosyl compounds gene gene566 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00567 VSVS12_00568 VSVS12_00568 trmB trmB 591043 591762 + tRNA (guanine(46)-N(7))-methyltransferase Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA%3B Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family%3B KEGG: vvu:VV1_1516 tRNA (guanine-N7-)-methyltransferase gene gene567 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00568 VSVS12_00569 VSVS12_00569 glsA glsA 591900 592820 + Glutaminase Belongs to the glutaminase family%3B KEGG: yru:BD65_1318 glutaminase gene gene568 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00569 VSVS12_00570 VSVS12_00570 VSVS12_00570 592992 594167 - Coproporphyrinogen dehydrogenase Involved in the biosynthesis of porphyrin-containing compound%3B Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemN-like subfamily%3B KEGG: vvu:VV1_1519 oxygen-independent coproporphyrinogen III oxidase gene gene569 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00570 VSVS12_00571 VSVS12_00571 rdgB rdgB 594171 594767 - XTP/dITP diphosphatase Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP/dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool%2C thus preventing their incorporation into DNA and avoiding chromosomal lesions%3B Belongs to the HAM1 NTPase family%3B KEGG: eco:b2954 XTP/dITP diphosphohydrolase gene gene570 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00571 VSVS12_00572 VSVS12_00572 VSVS12_00572 594780 595211 - hypothetical protein gene gene571 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00572 VSVS12_00573 VSVS12_00573 VSVS12_00573 595242 595532 - UPF0235 protein Belongs to the UPF0235 family gene gene572 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00573 VSVS12_00574 VSVS12_00574 VSVS12_00574 595532 596089 - uncharacterized protein Belongs to the YggT family gene gene573 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00574 VSVS12_00575 VSVS12_00575 proC proC 596131 596949 - Pyrroline-5-carboxylate reductase Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline%3B Belongs to the pyrroline-5-carboxylate reductase family%3B KEGG: yru:BD65_1312 pyrroline-5-carboxylate reductase gene gene574 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00575 VSVS12_00576 VSVS12_00576 VSVS12_00576 597000 597716 - UPF0001 protein Belongs to the UPF0001 family gene gene575 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00576 VSVS12_00577 VSVS12_00577 VSVS12_00577 597741 598772 + Twitching mobility protein May be involved in pilus retraction. Belongs to the GSP E family gene gene576 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00577 VSVS12_00578 VSVS12_00578 VSVS12_00578 598787 599887 + uncharacterized protein Belongs to the GSP E family gene gene577 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00578 VSVS12_00579 VSVS12_00579 lysC lysC 599949 601301 - Aspartate kinase Belongs to the aspartokinase family%3B Contains 1 ACT domain%3B KEGG: vch:VC0391 aspartate kinase gene gene578 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00579 VSVS12_00580 VSVS12_00580 agxT agxT 601765 602886 + Alanine--glyoxylate transaminase Dual metabolic roles of gluconeogenesis (in the mitochondria) and glyoxylate detoxification (in the peroxisomes). Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family%3B KEGG: vni:VIBNI_A3034 alanine-glyoxylate transaminase / serine-glyoxylate transaminase / serine-pyruvate transaminase gene gene579 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00580 VSVS12_00581 VSVS12_00581 VSVS12_00581 602966 604735 - hypothetical protein gene gene580 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00581 VSVS12_00582 VSVS12_00582 VSVS12_00582 604915 607737 - UvrABC system protein The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB%2C the UvrA molecules dissociate%3B Belongs to the ABC transporter superfamily. UvrA family%3B Contains 2 ABC transporter domains gene gene581 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00582 VSVS12_00583 VSVS12_00583 ugp2 ugp2 607921 608793 - UTP--glucose-1-phosphate uridylyltransferase May play a role in stationary phase survival%3B Belongs to the UDPGP type 2 family%3B KEGG: vch:VC0395 UTP--glucose-1-phosphate uridylyltransferase gene gene582 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00583 VSVS12_00584 VSVS12_00584 VSVS12_00584 608912 609559 - Fimbriae Z protein Contains 1 HTH luxR-type DNA-binding domain%3B Contains 1 response regulatory domain gene gene583 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00584 VSVS12_00585 VSVS12_00585 VSVS12_00585 609858 610397 + Single-stranded DNA-binding protein Plays an important role in DNA replication%2C recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism%3B Contains 1 SSB domain gene gene584 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00585 VSVS12_00586 VSVS12_00586 VSVS12_00586 610607 612574 + RNase E specificity factor CsrD Serves as a specificity factor required for RNase E- mediated decay of the small global regulatory RNAs CsrB and CsrC%2C it is probably not a nuclease. Nor does its activity involve c-di- GMP%2C despite its domain composition. Positively modulates motility gene expression%2C is also required for curli expression%3B Contains 1 EAL domain%3B Contains 1 GGDEF domain gene gene585 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00586 VSVS12_00587 VSVS12_00587 VSVS12_00587 612582 614024 + hypothetical protein gene gene586 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00587 VSVS12_00588 VSVS12_00588 VSVS12_00588 614021 614671 + hypothetical protein gene gene587 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00588 VSVS12_00589 VSVS12_00589 VSVS12_00589 614664 615002 + hypothetical protein gene gene588 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00589 VSVS12_00590 VSVS12_00590 VSVS12_00590 615018 616658 + Type II secretion system protein Involved in a type II secretion system (T2SS%2C formerly general secretion pathway%2C GSP) for the export of proteins%3B Belongs to the GSP D family gene gene589 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00590 VSVS12_00591 VSVS12_00591 VSVS12_00591 616665 617504 + General secretion pathway protein A Involved in a general secretion pathway (GSP) for the export of proteins. Belongs to the ExeA family gene gene590 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00591 VSVS12_00592 VSVS12_00592 VSVS12_00592 617508 618752 + hypothetical protein gene gene591 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00592 VSVS12_00593 VSVS12_00593 VSVS12_00593 618742 619677 + Type IV pilus assembly protein PilF Involved in the translocation of the type IV pilin. Belongs to the GSP E family gene gene592 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00593 VSVS12_00594 VSVS12_00594 VSVS12_00594 619635 620843 - hypothetical protein gene gene593 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00594 VSVS12_00595 VSVS12_00595 VSVS12_00595 620950 621804 + Type II secretion system protein Involved in a type II secretion system (T2SS%2C formerly general secretion pathway%2C GSP) for the export of proteins. Required for secretion of cholera toxin through the outer membrane. Belongs to the GSP E family gene gene594 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00595 VSVS12_00596 VSVS12_00596 VSVS12_00596 621813 623033 + Putative type II secretion system protein Involved in a type II secretion system (T2SS%2C formerly general secretion pathway%2C GSP) for the export of proteins%3B Belongs to the GSP F family gene gene595 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00596 VSVS12_00597 VSVS12_00597 VSVS12_00597 623017 623496 + hypothetical protein gene gene596 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00597 VSVS12_00598 VSVS12_00598 VSVS12_00598 623577 624152 + hypothetical protein gene gene597 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00598 VSVS12_00599 VSVS12_00599 VSVS12_00599 624189 624650 + hypothetical protein gene gene598 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00599 VSVS12_00600 VSVS12_00600 VSVS12_00600 624772 625239 + hypothetical protein gene gene599 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00600 VSVS12_00601 VSVS12_00601 VSVS12_00601 625239 625796 + hypothetical protein gene gene600 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00601 VSVS12_00602 VSVS12_00602 VSVS12_00602 625796 626548 + hypothetical protein gene gene601 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00602 VSVS12_00603 VSVS12_00603 VSVS12_00603 626538 627050 + hypothetical protein gene gene602 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00603 VSVS12_00604 VSVS12_00604 VSVS12_00604 627050 629311 + hypothetical protein gene gene603 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00604 VSVS12_00605 VSVS12_00605 VSVS12_00605 629320 630486 + hypothetical protein gene gene604 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00605 VSVS12_00606 VSVS12_00606 VSVS12_00606 630639 631682 + Rod shape-determining protein MreB Involved in formation of the rod shape of the cell%3B Belongs to the FtsA/MreB family gene gene605 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00606 VSVS12_00607 VSVS12_00607 VSVS12_00607 631742 632629 + Cell shape-determining protein MreC Involved in formation and maintenance of cell shape. Responsible for formation of rod shape. May also contribute to regulation of formation of penicillin-binding proteins%3B Belongs to the MreC family gene gene606 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00607 VSVS12_00608 VSVS12_00608 VSVS12_00608 632619 633107 + Rod shape-determining protein Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins (By similarity)%3B Belongs to the MreD family gene gene607 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00608 VSVS12_00609 VSVS12_00609 VSVS12_00609 633110 633670 + Maf-like protein Belongs to the maf family gene gene608 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00609 VSVS12_00610 VSVS12_00610 cafA cafA 633690 635159 + Ribonuclease Involved in the processing of the 5'-end of 16S rRNA. Could be involved in chromosome segregation and cell division. It may be one of the components of the cytoplasmic axial filaments bundles or merely regulate the formation of this structure (By similarity)%3B Belongs to the RNase E/G family. RNase G subfamily%3B Contains 1 S1 motif domain%3B KEGG: eco:b3247 ribonuclease G%3B Endoribonucleases producing 5'-phosphomonoesters gene gene609 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00610 VSVS12_00611 VSVS12_00611 VSVS12_00611 635170 639042 + uncharacterized protein gene gene610 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00611 VSVS12_00612 VSVS12_00612 VSVS12_00612 639072 639890 + Nitrilase Cleaves A-5'-PPP-5'A to yield AMP and ADP%3B In the N-terminal sectio%3B belongs to the UPF0012 family%3B Contains 1 CN hydrolase domain%3B Contains 1 HIT domain%3B KEGG: swi:Swit_2469 nitrilase gene gene611 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00612 VSVS12_00613 VSVS12_00613 VSVS12_00613 639900 641345 + Metalloprotease TldD like protein Probable metalloprotease%3B Belongs to the peptidase U62 family gene gene612 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00613 VSVS12_00614 VSVS12_00614 VSVS12_00614 641297 641416 - hypothetical protein gene gene613 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00614 VSVS12_00615 VSVS12_00615 arcA arcA 641546 642766 - Arginine deiminase Belongs to the arginine deiminase family%3B KEGG: vch:VC0423 arginine deiminase gene gene614 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00615 VSVS12_00616 VSVS12_00616 VSVS12_00616 643307 643729 + Regulator of ribonuclease activity Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome%3B Belongs to the RraB family gene gene615 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00616 VSVS12_00617 VSVS12_00617 VSVS12_00617 643870 645507 + hypothetical protein gene gene616 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00617 VSVS12_00618 VSVS12_00618 VSVS12_00618 645504 647348 + hypothetical protein gene gene617 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00618 VSVS12_00619 VSVS12_00619 VSVS12_00619 647351 649366 + hypothetical protein gene gene618 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00619 VSVS12_00620 VSVS12_00620 VSVS12_00620 649376 649861 + hypothetical protein gene gene619 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00620 VSVS12_00621 VSVS12_00621 VSVS12_00621 650227 652008 + hypothetical protein gene gene620 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00621 VSVS12_00622 VSVS12_00622 penP penP 652198 653046 - Beta-lactamase Hydrolyzes carbenicillin. Methicillin and oxacillin are weakly hydrolyzed. Belongs to the class-A beta-lactamase family%3B KEGG: pva:Pvag_pPag30396 beta-lactamase class A gene gene621 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00622 VSVS12_00623 VSVS12_00623 VSVS12_00623 653620 655689 + hypothetical protein gene gene622 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00623 VSVS12_00624 VSVS12_00624 manB manB 656141 656941 + Beta-mannosidase KEGG: vvy:VVA0201 beta-mannosidase gene gene623 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00624 VSVS12_00625 VSVS12_00625 VSVS12_00625 656949 657347 - hypothetical protein gene gene624 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00625 VSVS12_00626 VSVS12_00626 VSVS12_00626 657501 657938 - hypothetical protein gene gene625 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00626 VSVS12_00627 VSVS12_00627 VSVS12_00627 657982 660561 - Putative TRAP transporter large permease protein Belongs to the TRAP transporter large permease family gene gene626 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00627 VSVS12_00628 VSVS12_00628 VSVS12_00628 660779 661747 - 31 kDa immunogenic protein gene gene627 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00628 VSVS12_00629 VSVS12_00629 VSVS12_00629 662081 662551 - Arginine repressor Regulates arginine biosynthesis genes%3B Belongs to the ArgR family gene gene628 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00629 VSVS12_00630 VSVS12_00630 VSVS12_00630 662882 663817 + Malate dehydrogenase Catalyzes the reversible oxidation of malate to oxaloacetate%3B Belongs to the LDH/MDH superfamily. MDH type 1 family%3B KEGG: eco:b3236 malate dehydrogenase gene gene629 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00630 VSVS12_00631 VSVS12_00631 VSVS12_00631 663913 664104 + hypothetical protein gene gene630 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00631 VSVS12_00632 VSVS12_00632 ispB ispB 664178 665149 - All-trans-octaprenyl-diphosphate synthase Supplies octaprenyl diphosphate%2C the precursor for the side chain of the isoprenoid quinones ubiquinone and menaquinone%3B Belongs to the FPP/GGPP synthase family%3B KEGG: vsp:VS_0360 octaprenyl-diphosphate synthase gene gene631 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00632 VSVS12_00633 VSVS12_00633 VSVS12_00633 665420 665731 + 50S ribosomal protein L21 This protein binds to 23S rRNA in the presence of protein L20%3B Belongs to the ribosomal protein L21P family gene gene632 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00633 VSVS12_00634 VSVS12_00634 VSVS12_00634 665753 666013 + 50S ribosomal protein L27 Belongs to the ribosomal protein L27P family gene gene633 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00634 VSVS12_00635 VSVS12_00635 VSVS12_00635 666301 667476 + GTPase Obg An essential GTPase which binds GTP%2C GDP and possibly (p)ppGpp with moderate affinity%2C with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle%2C stress response%2C ribosome biogenesis and in those bacteria that undergo differentiation%2C in morphogenesis control%3B Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family%3B Contains 1 OBG-type G (guanine nucleotide-binding) domain gene gene634 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00635 VSVS12_00636 VSVS12_00636 VSVS12_00636 667675 668442 + Inner membrane protein YjjP To H. influenzae HI_0108 gene gene635 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00636 VSVS12_00637 VSVS12_00637 VSVS12_00637 668439 668912 + uncharacterized protein To E. coli YjjP gene gene636 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00637 VSVS12_00638 VSVS12_00638 folA folA 668955 669434 + Dihydrofolate reductase Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis%2C and for DNA precursor synthesis (By similarity)%3B Belongs to the dihydrofolate reductase family%3B Contains 1 DHFR (dihydrofolate reductase) domain%3B KEGG: ype:YPO0486 dihydrofolate reductase gene gene637 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00638 VSVS12_00639 VSVS12_00639 apaH apaH 669581 670387 - Bis(5'-nucleosyl)-tetraphosphatase (symmetrical) Hydrolyzes diadenosine 5'%2C5'''-P1%2CP4-tetraphosphate to yield ADP%3B Belongs to the Ap4A hydrolase family%3B KEGG: eco:b0049 bis(5'-nucleosyl)-tetraphosphatase (symmetrical) gene gene638 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00639 VSVS12_00640 VSVS12_00640 VSVS12_00640 670397 670777 - Protein ApaG Contains 1 apaG domain gene gene639 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00640 VSVS12_00641 VSVS12_00641 ksgA ksgA 670841 671647 - 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits%3B Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily%3B KEGG: vch:VC0443 16S rRNA (adenine1518-N6/adenine1519-N6)-dimethyltransferase gene gene640 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00641 VSVS12_00642 VSVS12_00642 pdxA pdxA 671644 672633 - 4-hydroxythreonine-4-phosphate dehydrogenase Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)%3B Belongs to the PdxA family%3B KEGG: dze:Dd1591_0564 4-hydroxythreonine-4-phosphate dehydrogenase gene gene641 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00642 VSVS12_00643 VSVS12_00643 surA surA 672623 673918 - Peptidylprolyl isomerase Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains%2C which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation%3B Contains 2 PpiC domains%3B KEGG: vfi:VF_0288 peptidyl-prolyl cis-trans isomerase SurA gene gene642 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00643 VSVS12_00644 VSVS12_00644 VSVS12_00644 673970 676342 - LPS-assembly protein LptD Together with LptE%2C is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane%3B Belongs to the LptD family gene gene643 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00644 VSVS12_00645 VSVS12_00645 VSVS12_00645 676543 677397 + DnaJ-like protein DjlA Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon%2C involved in the synthesis of a colanic acid polysaccharide capsule%2C possibly through activation of the RcsB/RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host%3B Contains 1 J domain gene gene644 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00645 VSVS12_00646 VSVS12_00646 VSVS12_00646 677483 677872 - 2-iminobutanoate/2-iminopropanoate deaminase May be a post-translational regulator that controls the metabolic fate of L-threonine or the potentially toxic intermediate 2-ketobutyrate%3B Belongs to the RutC family%3B KEGG: eco:b3113 2-iminobutanoate/2-iminopropanoate deaminase gene gene645 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00646 VSVS12_00647 VSVS12_00647 VSVS12_00647 678016 678477 - Aspartate carbamoyltransferase regulatory chain Involved in allosteric regulation of aspartate carbamoyltransferase%3B Belongs to the PyrI family gene gene646 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00647 VSVS12_00648 VSVS12_00648 pyrB pyrB 678494 679423 - Aspartate carbamoyltransferase Belongs to the ATCase/OTCase family%3B KEGG: bak:BAKON_372 aspartate carbamoyltransferase catalytic subunit gene gene647 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00648 VSVS12_00649 VSVS12_00649 argF argF 679696 680700 - Ornithine carbamoyltransferase Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline%3B Belongs to the ATCase/OTCase family%3B KEGG: hin:HI0596 ornithine carbamoyltransferase gene gene648 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00649 VSVS12_00650 VSVS12_00650 VSVS12_00650 680830 682206 - uncharacterized protein In the C-terminal sectio%3B belongs to the PhoH family%3B Contains 1 PINc domain gene gene649 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00650 VSVS12_00651 VSVS12_00651 hepA hepA 682791 685700 + RNA polymerase-associated protein RapA Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP%2C when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair%3B Belongs to the SNF2/RAD54 helicase family. RapA subfamily%3B Contains 1 helicase ATP-binding domain%3B Contains 1 helicase C-terminal domain%3B KEGG: hin:HI0616 ATP-dependent helicase HepA%3B Acting on ATP%3B involved in cellular and subcellular movement gene gene650 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00651 VSVS12_00652 VSVS12_00652 rluA rluA 685948 686685 + tRNA pseudouridine(32) synthase Responsible for synthesis of pseudouridine from uracil- 746 in 23S ribosomal RNA and from uracil-32 in the anticodon stem and loop of transfer RNAs%3B Belongs to the pseudouridine synthase RluA family%3B KEGG: hin:HI0617 tRNA pseudouridine32 synthase / 23S rRNA pseudouridine746 synthase gene gene651 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00652 VSVS12_00653 VSVS12_00653 hprA hprA 686741 687703 + Glycerate dehydrogenase Plays a central role in assimilation of carbon. It converts hydroxypyruvate to glycerate as a key step in the serine cycle%2C and may also play an important role in C2 reactions%2C by interconverting glyoxylate and glycolate. Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family%3B KEGG: vag:N646_1770 glycerate dehydrogenase gene gene652 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00653 VSVS12_00654 VSVS12_00654 larS larS 687794 690667 - Leucine--tRNA ligase Belongs to the class-I aminoacyl-tRNA synthetase family%3B KEGG: bpn:BPEN_321 leucyl-tRNA synthetase gene gene653 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00654 VSVS12_00655 VSVS12_00655 holC holC 690874 691323 - DNA-directed DNA polymerase KEGG: eco:b4259 DNA polymerase III subunit chi gene gene654 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00655 VSVS12_00656 VSVS12_00656 carP carP 691479 692999 - Leucyl aminopeptidase Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)%3B Belongs to the peptidase M17 family%3B KEGG: eco:b4260 leucyl aminopeptidase gene gene655 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00656 VSVS12_00657 VSVS12_00657 VSVS12_00657 693192 694295 + Lipopolysaccharide export system permease protein LptF Part of the ABC transporter complex LptBFG involved in the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane%3B Belongs to the LptF/LptG family gene gene656 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00657 VSVS12_00658 VSVS12_00658 VSVS12_00658 694299 695369 + Lipopolysaccharide export system permease protein LptG Part of the ABC transporter complex LptBFG involved in the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane%3B Belongs to the LptF/LptG family gene gene657 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00658 VSVS12_00659 VSVS12_00659 VSVS12_00659 695451 695573 - hypothetical protein gene gene658 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00659 VSVS12_00660 VSVS12_00660 nadC nadC 695739 696626 - Nicotinate-nucleotide diphosphorylase (carboxylating) Involved in the catabolism of quinolinic acid (QA)%3B Belongs to the NadC/ModD family%3B KEGG: vch:VC2422 nicotinate-nucleotide pyrophosphorylase (carboxylating) gene gene659 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00660 VSVS12_00661 VSVS12_00661 VSVS12_00661 696750 697292 + 1%2C6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD Involved in both cell wall peptidoglycans recycling and beta-lactamase induction. Specifically cleaves the amide bond between the lactyl group of N-acetylmuramic acid and the alpha- amino group of the L-alanine in degradation products containing an anhydro N-acetylmuramyl moiety (By similarity)%3B Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family gene gene660 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00661 VSVS12_00662 VSVS12_00662 VSVS12_00662 697394 697918 - Flavodoxin Low-potential electron donor to a number of redox enzymes%3B Belongs to the flavodoxin family%3B Contains 1 flavodoxin-like domain gene gene661 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00662 VSVS12_00663 VSVS12_00663 VSVS12_00663 698084 698980 + Tyrosine recombinase XerD Site-specific tyrosine recombinase%2C which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)%3B Belongs to the 'phage' integrase family. XerD subfamily gene gene662 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00663 VSVS12_00664 VSVS12_00664 dsbC dsbC 699016 699762 + Protein disulfide-isomerase Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process. DsbC is reoxidized by a yet uncharacterized protein. Also acts as a disulfide isomerase. Belongs to the thioredoxin family. DsbC subfamily%3B Contains 1 thioredoxin domain%3B KEGG: vch:VC2418 thiol:disulfide interchange protein DsbC gene gene663 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00664 VSVS12_00665 VSVS12_00665 recJ recJ 699802 701544 + Single-stranded-DNA-specific exonuclease RecJ Single-stranded-DNA-specific exonuclease. Required for many types of recombinational events%2C although the stringency of the requirement for RecJ appears to vary with the type of recombinational event monitored and the other recombination gene products which are available%3B Belongs to the RecJ family%3B KEGG: ahy:AHML_17495 single-stranded-DNA-specific exonuclease%3B Acting on ester bonds gene gene664 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00665 VSVS12_00666 VSVS12_00666 VSVS12_00666 702050 702814 + Pyruvate dehydrogenase complex repressor Transcriptional repressor for the pyruvate dehydrogenase complex genes aceEF and lpd%3B Contains 1 HTH gntR-type DNA-binding domain gene gene665 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00666 VSVS12_00667 VSVS12_00667 aceE aceE 702846 705509 + Pyruvate dehydrogenase (acetyl-transferring) Component of the pyruvate dehydrogenase (PDH) complex%2C that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)%3B KEGG: vch:VC2414 pyruvate dehydrogenase E1 component gene gene666 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00667 VSVS12_00668 VSVS12_00668 dlaT dlaT 705539 707428 + Dihydrolipoyllysine-residue acetyltransferase The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1)%2C dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). Belongs to the 2-oxoacid dehydrogenase family%3B Contains 3 lipoyl-binding domains%3B KEGG: eco:b0115 pyruvate dehydrogenase E2 component (dihydrolipoamide acetyltransferase) gene gene667 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00668 VSVS12_00669 VSVS12_00669 VSVS12_00669 707712 709142 + Dihydrolipoyl dehydrogenase The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of 3 enzymatic components: branched-chain alpha-keto acid decarboxylase (E1)%2C lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity)%3B Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family%3B KEGG: vch:VC2412 dihydrolipoamide dehydrogenase gene gene668 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00669 VSVS12_00670 VSVS12_00670 VSVS12_00670 709225 709839 - HTH-type transcriptional regulator LuxR Regulatory protein of bacterial bioluminescence. It probably binds the autoinducer molecule and potentiates the transcription of the bioluminescence operon. Contains 1 HTH tetR-type DNA-binding domain gene gene669 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00670 VSVS12_00671 VSVS12_00671 hprT hprT 710247 710777 + Hypoxanthine phosphoribosyltransferase Acts preferentially on hypoxanthin%3B has very low activity towards guanine. Inactive towards xanthine (By similarity)%3B Belongs to the purine/pyrimidine phosphoribosyltransferase family%3B KEGG: ype:YPO3408 hypoxanthine phosphoribosyltransferase gene gene670 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00671 VSVS12_00672 VSVS12_00672 cynT cynT 710877 711545 - Carbonate dehydratase Belongs to the beta-class carbonic anhydrase family%3B KEGG: hin:HI1301 carbonic anhydrase gene gene671 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00672 VSVS12_00673 VSVS12_00673 VSVS12_00673 711791 712273 + Bicarbonate transporter BicA Low/medium affinity%2C Na(+)-dependent bicarbonate transporter%3B Belongs to the SLC26A/SulP transporter (TC 2. A. 53) family%3B Contains 1 STAS domain gene gene672 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00673 VSVS12_00674 VSVS12_00674 VSVS12_00674 712377 713585 + hypothetical protein gene gene673 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00674 VSVS12_00675 VSVS12_00675 VSVS12_00675 713582 714802 + Bicarbonate transporter BicA Low/medium affinity%2C Na(+)-dependent bicarbonate transporter%3B Belongs to the SLC26A/SulP transporter (TC 2. A. 53) family%3B Contains 1 STAS domain gene gene674 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00675 VSVS12_00676 VSVS12_00676 VSVS12_00676 715003 715926 + putative ABC transporter ATP-binding protein Belongs to the ABC transporter superfamily%3B Contains 1 ABC transporter domain gene gene675 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00676 VSVS12_00677 VSVS12_00677 VSVS12_00677 715928 716698 + Inner membrane transport permease Belongs to the ABC-2 integral membrane protein family%3B Contains 1 ABC transmembrane type-2 domain gene gene676 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00677 VSVS12_00678 VSVS12_00678 panC panC 716864 717766 - Pantoate--beta-alanine ligase (AMP-forming) Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate%3B Belongs to the pantothenate synthetase family%3B KEGG: vvu:VV1_1642 pantoate--beta-alanine ligase gene gene677 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00678 VSVS12_00679 VSVS12_00679 panB panB 717778 718572 - 3-methyl-2-oxobutanoate hydroxymethyltransferase Catalyzes the reversible reaction in which hydroxymethyl group from 5%2C10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate%3B Belongs to the PanB family%3B KEGG: vch:VC0592 3-methyl-2-oxobutanoate hydroxymethyltransferase gene gene678 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00679 VSVS12_00680 VSVS12_00680 folK folK 718596 719081 - 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase Belongs to the HPPK family%3B KEGG: hin:HI0064 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase gene gene679 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00680 VSVS12_00681 VSVS12_00681 pcnB pcnB 719078 720454 - Polynucleotide adenylyltransferase Adds poly(A) tail to the 3' end of many RNAs%2C which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression%2C through influencing the rate of transcript degradation%2C and in the general RNA quality control%3B Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family%3B KEGG: van:VAA_00753 poly(A) polymerase gene gene680 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00681 VSVS12_00682 VSVS12_00682 gluQ gluQ 720540 721430 - Glutamyl-Q tRNA(Asp) synthetase Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4%2C5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon%3B Belongs to the class-I aminoacyl-tRNA synthetase family. GluQ subfamily%3B KEGG: sgl:SG0491 glutamyl-Q tRNA(Asp) synthetase%3B Ligases forming aminoacyl-tRNA and related compounds gene gene681 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00682 VSVS12_00683 VSVS12_00683 VSVS12_00683 721507 721953 - RNA polymerase-binding transcription factor DksA Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters. Also required for regulation of fis expression%3B Belongs to the DksA family%3B Contains 1 dksA C4-type zinc finger gene gene682 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00683 VSVS12_00684 VSVS12_00684 VSVS12_00684 722083 722802 - Sugar fermentation stimulation protein like protein Belongs to the SfsA family gene gene683 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00684 VSVS12_00685 VSVS12_00685 hrpB hrpB 722804 725350 + RNA helicase Belongs to the DEAD box helicase family%3B Contains 1 helicase ATP-binding domain%3B Contains 1 helicase C-terminal domain%3B KEGG: vph:VPUCM_2588 ATP-dependent helicase HrpB gene gene684 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00685 VSVS12_00686 VSVS12_00686 mrcB mrcB 725378 727744 + Penicillin-binding protein 1B Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits) (By similarity)%3B In the N-terminal sectio%3B belongs to the glycosyltransferase 51 family%3B In the C-terminal sectio%3B belongs to the transpeptidase family%3B KEGG: vfi:VF_2162 penicillin-binding protein 1B%3B Peptidoglycan glycosyltransferase gene gene685 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00686 VSVS12_00687 VSVS12_00687 VSVS12_00687 727827 730109 + Lysophospholipase NTE1 Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. Responsible for the rapid PC turnover in response to inositol%2C elevated temperatures%2C or when choline is present in the growth medium (By similarity)%3B Belongs to the NTE family%3B Contains 2 cyclic nucleotide-binding domains%3B Contains 1 patatin domain gene gene686 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00687 VSVS12_00688 VSVS12_00688 acnB acnB 730387 732975 + Aconitate hydratase Involved in the catabolism of short chain fatty acids (SCFA) via the tricarboxylic acid (TCA)(acetyl degradation route) and probably via the 2-methylcitrate cycle I (propionate degradation route). Catalyzes the reversible isomerization of citrate to isocitrate via cis-aconitate. Catalyzes the hydration of 2-methyl-cis-aconitate to yield (2R%2C3S)-2-methylisocitrate. The apo form of AcnB functions as a RNA-binding regulatory protein%3B Belongs to the aconitase/IPM isomerase family%3B KEGG: kox:KOX_16605 aconitate hydratase 2 / 2-methylisocitrate dehydratase gene gene687 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00688 VSVS12_00689 VSVS12_00689 glxK glxK 733236 734369 - Glycerate 3-kinase Belongs to the glycerate kinase type-1 family%3B KEGG: eco:b0514 glycerate kinase gene gene688 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00689 VSVS12_00690 VSVS12_00690 VSVS12_00690 734389 735654 - putative transporter Belongs to the CitM (TC 2. A. 11) transporter family gene gene689 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00690 VSVS12_00691 VSVS12_00691 VSVS12_00691 735788 736939 - Carbohydrate diacid regulator Seems to regulate the expression of the operons for the enzymes involved in D-galactarate%2C D-glucarate and D-glycerate utilization. Belongs to the CdaR family gene gene690 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00691 VSVS12_00692 VSVS12_00692 VSVS12_00692 737186 737557 + UPF0231 protein Belongs to the UPF0231 family gene gene691 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00692 VSVS12_00693 VSVS12_00693 VSVS12_00693 737788 738126 + Nitrogen regulatory protein P-II In nitrogen-limiting conditions%2C when the ratio of Gln to 2-ketoglutarate decreases%2C P-II is uridylylated to P-II-UMP. P- II-UMP allows the deadenylation of glutamine synthetase (GS)%2C thus activating the enzyme. Conversely%2C in nitrogen excess P-II is deuridylated and promotes the adenylation of GS. P-II indirectly controls the transcription of the GS gene (glnA). P-II prevents NR-II-catalyzed conversion of NR-I to NR-I-phosphate%2C the transcriptional activator of glnA. When P-II is uridylylated to P- II-UMP%2C these events are reversed (By similarity)%3B Belongs to the P(II) protein family gene gene692 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00693 VSVS12_00694 VSVS12_00694 VSVS12_00694 738144 739379 + Putative ammonium transporter Belongs to the ammonia transporter channel (TC 1. A. 11. 2) family gene gene693 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00694 VSVS12_00695 VSVS12_00695 VSVS12_00695 739531 740544 + Iron uptake protein Plays an important role in protecting the acceptor side of photosystem II (PSII) against oxidative damage%2C especially under iron-limiting growth conditions (Probable). The differing subcellular locations of futA1 (predominantly thylakoid lumen) and futA2 (predominantly periplasmic) suggest they may fulfill different roles%3B A major iron-binding protein involved in Fe(3+) uptake%2C probably part of a periplasmic ABC transporter complex futA1A2BC (TC 3. A. 1. 10. 2) involved in Fe(3+) ion import (ferric iron). This protein and futA2 (slr0531) may be subunit proteins that have redundant or overlapping substrate-binding functions (Probable)%3B Belongs to the bacterial solute-binding protein 1 family gene gene694 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00695 VSVS12_00696 VSVS12_00696 VSVS12_00696 740632 742257 + Fe(3+)-transport system permease protein FbpB Part of the ABC transporter complex FbpABC (TC 3. A. 1. 10. 1) involved in Fe(3+) ions import. Probably responsible for the translocation of the substrate across the membrane (By similarity)%3B Belongs to the binding-protein-dependent transport system permease family. FbpB subfamily%3B Contains 2 ABC transmembrane type-1 domains gene gene695 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00696 VSVS12_00697 VSVS12_00697 afuC afuC 742257 743288 + Fe(3+)-transporting ATPase Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system%3B Belongs to the ABC transporter superfamily. Phosphonates importer (TC 3. A. 1. 9. 1) family%3B Contains 1 ABC transporter domain%3B KEGG: vcy:IX92_12755 iron(III) transport system ATP-binding protein gene gene696 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00697 VSVS12_00698 VSVS12_00698 VSVS12_00698 743285 743563 - hypothetical protein gene gene697 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00698 VSVS12_00699 VSVS12_00699 pfpI pfpI 743661 744221 - Protein DJ-1 like protein Possesses glyoxalase I activity. Catalyzes the conversion of hemimercaptal%2C formed from methylglyoxal and glutathione%2C to S-lactoylglutathione. May be involved in oxidative stress response%3B Belongs to the peptidase C56 family%3B Contains 2 PfpI endopeptidase domains%3B KEGG: pwa:Pecwa_4093 protease I%3B Glycosylases gene gene698 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00699 VSVS12_00700 VSVS12_00700 VSVS12_00700 744383 745795 - Phosphoglucomutase (alpha-D-glucose-1%2C6-bisphosphate-dependent) Belongs to the phosphohexose mutase family%3B KEGG: glo:Glov_1605 phosphoglucomutase gene gene699 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00700 VSVS12_00701 VSVS12_00701 chbP chbP 745845 748253 - N%2CN'-diacetylchitobiose phosphorylase Catalyzes the phosphorolysis of cellobiose%2C yielding glucose 1-phosphate and glucose. Is inactive against cellotriose and the disaccharides lactose%2C chitobiose and xylobiose. May be the primary enzyme for processing cellobiose in T. neapolitana%3B Belongs to the glycosyl hydrolase 94 family%3B KEGG: vch:VC0612 N%2CN'-diacetylchitobiose phosphorylase gene gene700 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00701 VSVS12_00702 VSVS12_00702 VSVS12_00702 748347 750260 - Beta-N-acetylhexosaminidase Hydrolyzes rapidly p-nitrophenyl-N-acetyl-beta-D- glucosaminide (PNP-beta-GlcNAc) and 4-methylumbelliferyl-beta- GlcNAc%2C and slightly active on p-nitrophenyl-beta-GalNAc. Hydrolyzes aryl-N-acetyl-beta-D-glucosaminide (aryl-beta-GlcNAc)%2C aryl-beta-GalNAc and chitin oligosaccharides. This enzyme is not processive%2C i. e. when it hydrolyzes (GlcNAc)n%2C both products%2C (Glc-NAc)n-1 and the terminal GlcNAc%2C are released before the enzyme attacks a second molecule of (GlcNAc)n or (GlcNAc)n-1. Belongs to the glycosyl hydrolase 20 family%3B KEGG: vcy:IX92_12740 hexosaminidase gene gene701 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00702 VSVS12_00703 VSVS12_00703 gspK gspK 750273 751148 - Glucosamine kinase ATP-dependent kinase%2C which is specific for glucosamine. Does not show kinase activity with any other sugar%3B Belongs to the eukaryotic-type N-acetylglucosamine kinase family%3B KEGG: serr:Ser39006_3702 glucosamine kinase gene gene702 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00703 VSVS12_00704 VSVS12_00704 VSVS12_00704 751153 752871 - hypothetical protein gene gene703 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00704 VSVS12_00705 VSVS12_00705 VSVS12_00705 752952 753947 - Peptide transport system ATP-binding protein SapF Involved in a peptide intake transport system that plays a role in the resistance to antimicrobial peptides%3B Belongs to the ABC transporter superfamily%3B Contains 1 ABC transporter domain gene gene704 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00705 VSVS12_00706 VSVS12_00706 VSVS12_00706 753987 754970 - Lipoprotein-releasing system ATP-binding protein LolD Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins%2C from the inner membrane to the periplasmic chaperone%2C LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner%3B Belongs to the ABC transporter superfamily. Lipoprotein translocase (TC 3. A. 1. 125) family%3B Contains 1 ABC transporter domain gene gene705 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00706 VSVS12_00707 VSVS12_00707 VSVS12_00707 754973 755998 - Oligopeptide transport system permease protein AppC This protein is a component of an oligopeptide permease%2C a binding protein-dependent transport system. This APP system can completely substitute for the OPP system in both sporulation and genetic competence%2C though%2C unlike OPP%2C is incapable of transporting tripeptides. Probably responsible for the translocation of the substrate across the membrane (By similarity)%3B Belongs to the binding-protein-dependent transport system permease family. OppBC subfamily%3B Contains 1 ABC transmembrane type-1 domain gene gene706 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00707 VSVS12_00708 VSVS12_00708 VSVS12_00708 756001 756987 - Oligopeptide transport system permease protein OppB Part of the binding-protein-dependent transport system for oligopeptide%3B probably responsible for the translocation of the substrate across the membrane. Also required for sporulation and competence. Belongs to the binding-protein-dependent transport system permease family. OppBC subfamily%3B Contains 1 ABC transmembrane type-1 domain gene gene707 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00708 VSVS12_00709 VSVS12_00709 VSVS12_00709 757160 758842 - uncharacterized protein Possible binding-protein with either a transport or enzymatic activity. Belongs to the bacterial solute-binding protein 5 family gene gene708 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00709 VSVS12_00710 VSVS12_00710 VSVS12_00710 759485 762889 - Transducer protein Htr6 Potentially involved in chemo- or phototactic signal transduction%3B Contains 2 HAMP domains%3B Contains 1 methyl-accepting transducer domain%3B KEGG: vfi:VF_2138 null%3B Phosphotransferases with a nitrogenous group as acceptor gene gene709 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00710 VSVS12_00711 VSVS12_00711 rsmC rsmC 763062 764084 - 16S rRNA (guanine(1207)-N(2))-methyltransferase Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle%3B Belongs to the methyltransferase superfamily. RsmC family%3B KEGG: vpa:VP2477 16S rRNA (guanine1207-N2)-methyltransferase gene gene710 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00711 VSVS12_00712 VSVS12_00712 VSVS12_00712 764181 765383 - UPF0118 membrane protein Belongs to the UPF0118 (PerM) family gene gene711 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00712 VSVS12_00713 VSVS12_00713 VSVS12_00713 765388 765558 + hypothetical protein gene gene712 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00713 VSVS12_00714 VSVS12_00714 hemL hemL 765599 766891 - Glutamate-1-semialdehyde 2%2C1-aminomutase Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily%3B KEGG: yro:CH64_3351 glutamate-1-semialdehyde 2%2C1-aminomutase gene gene713 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00714 VSVS12_00715 VSVS12_00715 VSVS12_00715 767150 767518 + Iron-sulfur cluster insertion protein ErpA Required for insertion of 4Fe-4S clusters for at least IspG%3B Belongs to the HesB/IscA family gene gene714 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00715 VSVS12_00716 VSVS12_00716 VSVS12_00716 767797 768900 + uncharacterized protein Belongs to the membrane fusion protein (MFP) (TC 8. A. 1) family gene gene715 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00716 VSVS12_00717 VSVS12_00717 VSVS12_00717 768909 772076 + Multidrug resistance protein MdtB Belongs to the resistance-nodulation-cell division (RND) (TC 2. A. 6) family. MdtB subfamily gene gene716 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00717 VSVS12_00718 VSVS12_00718 mepM mepM 772183 773469 - Murein DD-endopeptidase MepM A murein DD-endopeptidase with specificity for D-Ala- meso-diaminopimelic acid (mDAP) cross-links. Its role is probably to cleave D-Ala-mDAP cross-links to allow insertion of new glycans and thus cell wall expansion. Functionally redundant with MepM and MepH (By similarity)%3B Belongs to the peptidase M23B family%3B Contains 1 LysM repeat%3B KEGG: aha:AHA_3724 murein DD-endopeptidase%3B Metalloendopeptidases gene gene717 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00718 VSVS12_00719 VSVS12_00719 yarS yarS 773598 774785 + Tyrosine--tRNA ligase Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)%3B Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 2 subfamily%3B Contains 1 S4 RNA-binding domain%3B KEGG: sml:Smlt0417 tyrosyl-tRNA synthetase gene gene718 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00719 VSVS12_00720 VSVS12_00720 VSVS12_00720 775230 776075 + Magnesium transporter MgtE Acts as a magnesium transporter%3B Belongs to the SLC41A transporter family%3B Contains 2 CBS domains gene gene719 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00720 VSVS12_00721 VSVS12_00721 dacB dacB 776054 777481 - D-alanyl-D-alanine carboxypeptidase DacB Not involved in transpeptidation but exclusively catalyzes a DD-carboxypeptidase and DD-endopeptidase reaction%3B Belongs to the peptidase S13 family%3B KEGG: van:VAA_00793 D-alanyl-D-alanine carboxypeptidase / D-alanyl-D-alanine-endopeptidase (penicillin-binding protein 4)%3B Serine-type D-Ala-D-Ala carboxypeptidase gene gene720 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00721 VSVS12_00722 VSVS12_00722 VSVS12_00722 777583 778644 - Outer membrane protein Forms pores that allow passive diffusion of small molecules across the outer membrane%3B Belongs to the Gram-negative porin family gene gene721 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00722 VSVS12_00723 VSVS12_00723 VSVS12_00723 779167 779640 + Transcription elongation factor GreA Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through%2C resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides%3B Belongs to the GreA/GreB family gene gene722 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00723 VSVS12_00724 VSVS12_00724 VSVS12_00724 779721 780017 - RNA-binding protein Contains 1 CRM domain gene gene723 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00724 VSVS12_00725 VSVS12_00725 rlmE rlmE 780156 780785 + 23S rRNA (uridine(2552)-2'-O)-methyltransferase Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit%3B Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family%3B KEGG: vch:VC0636 23S rRNA (uridine2552-2'-O)-methyltransferase gene gene724 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00725 VSVS12_00726 VSVS12_00726 ftsH ftsH 780893 782857 + ATP-dependent zinc metalloprotease FtsH Acts as a processive%2C ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins%3B In the central sectio%3B belongs to the AAA ATPase family%3B In the C-terminal sectio%3B belongs to the peptidase M41 family%3B KEGG: eco:b3178 cell division protease FtsH%3B Metalloendopeptidases gene gene725 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00726 VSVS12_00727 VSVS12_00727 folP folP 782906 783739 + Dihydropteroate synthase Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7%2C8-dihydropterin diphosphate (DHPt-PP) to form 7%2C8-dihydropteroate (H2Pte)%2C the immediate precursor of folate derivatives%3B Belongs to the DHPS family%3B Contains 1 pterin-binding domain%3B KEGG: aah:CF65_00635 dihydropteroate synthase gene gene726 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00727 VSVS12_00728 VSVS12_00728 glmM glmM 783756 785096 + Phosphoglucosamine mutase Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate%3B Belongs to the phosphohexose mutase family%3B KEGG: vch:VC0639 phosphoglucosamine mutase gene gene727 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00728 VSVS12_00729 VSVS12_00729 VSVS12_00729 785351 785689 + Protein-export membrane protein SecG Involved in protein export. Participates in an early event of protein translocation (By similarity)%3B Belongs to the SecG family gene gene728 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00729 VSVS12_00730 VSVS12_00730 VSVS12_00730 785699 785782 + tRNA-Leu tRNA gene729 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00730 VSVS12_00731 VSVS12_00731 VSVS12_00731 785839 785915 + tRNA-Met tRNA gene730 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00731 VSVS12_00732 VSVS12_00732 VSVS12_00732 786122 786577 + Ribosome maturation factor RimP Required for maturation of 30S ribosomal subunits%3B Belongs to the RimP family gene gene731 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00732 VSVS12_00733 VSVS12_00733 VSVS12_00733 786612 788099 + Transcription termination/antitermination protein NusA Participates in both transcription termination and antitermination%3B Belongs to the NusA family%3B Contains 1 KH domain%3B Contains 1 S1 motif domain gene gene732 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00733 VSVS12_00734 VSVS12_00734 VSVS12_00734 788121 790826 + Translation initiation factor IF-2 One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex%3B Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily%3B Contains 1 tr-type G (guanine nucleotide-binding) domain gene gene733 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00734 VSVS12_00735 VSVS12_00735 VSVS12_00735 790938 791333 + Ribosome-binding factor Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA%3B Belongs to the RbfA family gene gene734 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00735 VSVS12_00736 VSVS12_00736 truB truB 791333 792286 + tRNA pseudouridine(55) synthase Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs%3B Belongs to the pseudouridine synthase TruB family. Type 1 subfamily%3B KEGG: pay:PAU_04027 tRNA pseudouridine55 synthase gene gene735 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00736 VSVS12_00737 VSVS12_00737 VSVS12_00737 792447 792812 - hypothetical protein gene gene736 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00737 VSVS12_00738 VSVS12_00738 VSVS12_00738 792960 793055 - hypothetical protein gene gene737 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00738 VSVS12_00739 VSVS12_00739 gltD gltD 793055 794524 - Glutamate synthase (NADPH) Contains 1 4Fe-4S ferredoxin-type domain%3B KEGG: vvu:VV1_0554 glutamate synthase (NADPH/NADH) small chain%3B overlaps another CDS with the same product name gene gene738 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00739 VSVS12_00740 VSVS12_00740 gltB gltB 794524 799071 - Glutamate synthase (NADPH) Belongs to the glutamate synthase family%3B Contains 1 glutamine amidotransferase type-2 domain%3B KEGG: vsa:VSAL_I2562 glutamate synthase (NADPH/NADH) large chain%3B overlaps another CDS with the same product name gene gene739 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00740 VSVS12_00741 VSVS12_00741 VSVS12_00741 799603 800532 + uncharacterized protein To M. jannaschii MJ0486 gene gene740 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00741 VSVS12_00742 VSVS12_00742 arcB arcB 800604 802352 + Histidine kinase Contains 1 GGDEF domain%3B KEGG: eca:ECA0314 two-component system%2C OmpR family%2C aerobic respiration control sensor histidine kinase ArcB gene gene741 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00742 VSVS12_00743 VSVS12_00743 VSVS12_00743 802433 804778 + Histidine kinase Member of the two-component regulatory system ArcB/ArcA. Sensor-regulator protein for anaerobic repression of the arc modulon. Activates ArcA via a four-step phosphorelay. ArcB can also dephosphorylate ArcA by a reverse phosphorelay involving His- 717 and Asp-576 (By similarity)%3B Contains 1 histidine kinase domain%3B Contains 1 HPt domain%3B Contains 1 PAC (PAS-associated C-terminal) domain%3B Contains 1 PAS (PER-ARNT-SIM) domain%3B Contains 1 response regulatory domain%3B KEGG: vch:VC2369 two-component system%2C OmpR family%2C aerobic respiration control sensor histidine kinase ArcB gene gene742 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00743 VSVS12_00744 VSVS12_00744 VSVS12_00744 804831 805277 + hypothetical protein gene gene743 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00744 VSVS12_00745 VSVS12_00745 VSVS12_00745 805588 805710 + hypothetical protein gene gene744 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00745 VSVS12_00746 VSVS12_00746 VSVS12_00746 805825 806076 + hypothetical protein gene gene745 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00746 VSVS12_00747 VSVS12_00747 VSVS12_00747 806117 807151 - Protein tas Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily%3B KEGG: aci:ACIAD1261 null%3B With NAD(+) or NADP(+) as acceptor gene gene746 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00747 VSVS12_00748 VSVS12_00748 VSVS12_00748 807371 807682 + hypothetical protein gene gene747 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00748 VSVS12_00749 VSVS12_00749 VSVS12_00749 807704 808372 - DNA mismatch repair protein MutH Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair%3B Belongs to the MutH family gene gene748 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00749 VSVS12_00750 VSVS12_00750 nudH nudH 808988 809506 + RNA pyrophosphohydrolase Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA%2C leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage%3B Belongs to the Nudix hydrolase family. RppH subfamily%3B Contains 1 nudix hydrolase domain%3B KEGG: vch:VC0671 putative (di)nucleoside polyphosphate hydrolase%3B In phosphorus-containing anhydrides gene gene749 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00750 VSVS12_00751 VSVS12_00751 ptsP ptsP 809509 811755 + Phosphoenolpyruvate--protein phosphotransferase Component of the phosphoenolpyruvate-dependent nitrogen- metabolic phosphotransferase system (nitrogen-metabolic PTS)%2C that seems to be involved in regulating nitrogen metabolism. Enzyme I- Ntr transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (NPr). Could function in the transcriptional regulation of sigma-54 dependent operons in conjunction with the NPr (PtsO) and EIIA-Ntr (PtsN) proteins%3B Belongs to the PEP-utilizing enzyme family%3B Contains 1 GAF domain%3B KEGG: eta:ETA_27610 phosphotransferase system%2C enzyme I%2C PtsP gene gene750 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00751 VSVS12_00752 VSVS12_00752 VSVS12_00752 811765 812556 + UPF0721 transmembrane protein Belongs to the UPF0721 family gene gene751 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00752 VSVS12_00753 VSVS12_00753 umpA umpA 812599 813423 + Prolipoprotein diacylglyceryl transferase Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins%3B Belongs to the Lgt family%3B KEGG: vch:VC0674 phosphatidylglycerol:prolipoprotein diacylglycerol transferase%3B Transferases gene gene752 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00753 VSVS12_00754 VSVS12_00754 thyA thyA 813433 814284 + Thymidylate synthase Provides the sole de novo source of dTMP for DNA biosynthesis%3B Belongs to the thymidylate synthase family. Bacterial- type ThyA subfamily%3B KEGG: pmr:PMI2318 thymidylate synthase gene gene753 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00754 VSVS12_00755 VSVS12_00755 VSVS12_00755 814732 815880 - Sodium-dependent phosphate transport protein 2A May be involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane. Probably mediates 70-80%25 of the apical influx. Belongs to the SLC34A transporter family gene gene754 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00755 VSVS12_00756 VSVS12_00756 VSVS12_00756 816303 817193 + Transcriptional activator protein NhaR Plays a role in the positive regulation of NhaA%3B Contains 1 HTH lysR-type DNA-binding domain gene gene755 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00756 VSVS12_00757 VSVS12_00757 VSVS12_00757 817312 817608 + Transcriptional activator HlyU Up-regulates the expression of the hemolysin gene%2C hlyA%2C and may promote expression of other virulence determinants in vivo. It may have both positive and negative regulator activities. Contains 1 HTH arsR-type DNA-binding domain gene gene756 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00757 VSVS12_00758 VSVS12_00758 VSVS12_00758 817703 817963 - 30S ribosomal protein S20 Binds directly to 16S ribosomal RNA%3B Belongs to the ribosomal protein S20P family gene gene757 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00758 VSVS12_00759 VSVS12_00759 VSVS12_00759 818223 819785 + Putative lipid II flippase MurJ Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane (By similarity)%3B Belongs to the MurJ/MviN family gene gene758 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00759 VSVS12_00760 VSVS12_00760 ribF ribF 819851 820786 + Riboflavin kinase Belongs to the RibF family%3B KEGG: sty:STY0054 riboflavin kinase / FMN adenylyltransferase gene gene759 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00760 VSVS12_00761 VSVS12_00761 iarS iarS 820851 823691 + Isoleucine--tRNA ligase Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine%2C to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)%3B Confers resistance to the antibiotic mupirocin (pseudomonic acid A)%2C an Ile-analog produced by P. fluorescens NCIMB 10586 itself that competitively inhibits activation by Ile- tRNA synthetase%2C thus inhibiting protein biosynthesis. Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily%3B KEGG: eco:b0026 isoleucyl-tRNA synthetase gene gene760 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00761 VSVS12_00762 VSVS12_00762 lspA lspA 823794 824300 + Signal peptidase II This protein specifically catalyzes the removal of signal peptides from prolipoproteins%3B Belongs to the peptidase A8 family%3B KEGG: vej:VEJY3_02415 signal peptidase II gene gene761 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00762 VSVS12_00763 VSVS12_00763 slpA slpA 824426 824857 + Peptidylprolyl isomerase PPIases accelerate the folding of proteins. Substrate specificity carried out with 'Suc-Ala-Xaa-Pro-Phe-4-nitroanilide'%2C where Xaa is the amino acid tested%2C was found to be Phe > Leu >> Ile > Lys %3D Ala > Trp > His >> Gln (By similarity)%3B Belongs to the FKBP-type PPIase family%3B Contains 1 PPIase FKBP-type domain%3B KEGG: vtu:IX91_02725 FKBP-type peptidyl-prolyl cis-trans isomerase SlpA gene gene762 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00763 VSVS12_00764 VSVS12_00764 ispH ispH 824893 825846 + 4-hydroxy-3-methylbut-2-enyl diphosphate reductase Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP)%3B Belongs to the IspH family%3B KEGG: eco:b0029 4-hydroxy-3-methylbut-2-enyl diphosphate reductase gene gene763 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00764 VSVS12_00765 VSVS12_00765 VSVS12_00765 825937 827424 - putative membrane protein Belongs to the CstA family gene gene764 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00765 VSVS12_00766 VSVS12_00766 VSVS12_00766 827636 827983 + hypothetical protein gene gene765 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00766 VSVS12_00767 VSVS12_00767 anmK anmK 828095 829210 - Anhydro-N-acetylmuramic acid kinase Catalyzes the specific phosphorylation of 1%2C6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1%2C6-anhydro ring%2C generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein%2C and thus plays a role in cell wall recycling%3B Belongs to the anhydro-N-acetylmuramic acid kinase family%3B KEGG: vvu:VV1_0497 anhydro-N-acetylmuramic acid kinase gene gene766 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00767 VSVS12_00768 VSVS12_00768 nagZ nagZ 829311 830300 + Beta-N-acetylhexosaminidase Belongs to the glycosyl hydrolase 3 family. NagZ subfamily%3B KEGG: vch:VC0692 beta-N-acetylhexosaminidase gene gene767 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00768 VSVS12_00769 VSVS12_00769 VSVS12_00769 830331 830435 + hypothetical protein gene gene768 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00769 VSVS12_00770 VSVS12_00770 VSVS12_00770 830429 831163 - putative response regulatory protein Contains 1 HTH LytTR-type DNA-binding domain%3B Contains 1 response regulatory domain gene gene769 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00770 VSVS12_00771 VSVS12_00771 VSVS12_00771 831173 832846 - Histidine kinase Member of the two-component regulatory system YehU/YehT%2C which may be involved in the stationary-phase control network. Activates YehT by phosphorylation (By similarity)%3B Contains 1 histidine kinase domain%3B KEGG: eca:ECA4152 two-component system%2C LytT family%2C sensor kinase gene gene770 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00771 VSVS12_00772 VSVS12_00772 aroF aroF 833091 834164 + 3-deoxy-7-phosphoheptulonate synthase Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP). Belongs to the class-I DAHP synthase family%3B KEGG: vch:VC0695 3-deoxy-7-phosphoheptulonate synthase gene gene771 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00772 VSVS12_00773 VSVS12_00773 tyrA tyrA 834186 835313 + Chorismate mutase Contains 1 chorismate mutase domain%3B Contains 1 prephenate/arogenate dehydrogenase domain%3B KEGG: aha:AHA_1655 chorismate mutase / prephenate dehydrogenase gene gene772 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00773 VSVS12_00774 VSVS12_00774 lytM lytM 835353 836336 - Lysostaphin Belongs to the peptidase M23B family%3B KEGG: har:HEAR2799 lysostaphin gene gene773 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00774 VSVS12_00775 VSVS12_00775 VSVS12_00775 836346 836717 - Cyclic diguanosine monophosphate-binding protein Binds the second messenger bis-(3'-5') cyclic dimeric guanosine monophosphate (c-di-GMP). Can bind two c-di-GMP molecules per monomer. May play a role in bacterial second- messenger regulated processes. Binding to c-di-GMP induces a conformational change of the C- and N-termini resulting in the exposure of a highly negative surface on one side of the protein to a possible effector protein%3B Contains 1 PilZ domain gene gene774 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00775 VSVS12_00776 VSVS12_00776 VSVS12_00776 836945 838612 - Sulfate-transporting ATPase A translation factor that gates the progression of the 70S ribosomal inititation complex (IC%2C containing tRNA(fMet) in the P site) into the translation elongation cycle by using a mechanism sensitive to the ATP/ADP ratio. Binds to the 70S ribosome E site where it modulates the state of the translating ribosome during subunit translocation (By similarity)%3B Belongs to the ABC transporter superfamily. ABCF family. Translational throttle EttA subfamily%3B Contains 2 ABC transporter domains%3B KEGG: afe:Lferr_0037 sulfate-transporting ATPase gene gene775 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00776 VSVS12_00777 VSVS12_00777 VSVS12_00777 838866 840821 + Soluble lytic murein transglycosylase Murein-degrading enzyme. Catalyzes the cleavage of the glycosidic bonds between N-acetylmuramic acid and N- acetylglucosamine residues in peptidoglycan. May play a role in recycling of muropeptides during cell elongation and/or cell division (By similarity)%3B Belongs to the transglycosylase Slt family%3B KEGG: gps:C427_5355 soluble lytic murein transglycosylase%3B Glycosidases%2C i. e. enzymes hydrolyzing O- and S-glycosyl compounds gene gene776 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00777 VSVS12_00778 VSVS12_00778 VSVS12_00778 840836 841138 + Trp operon repressor like protein This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon and prevents the initiation of transcription%3B Belongs to the TrpR family gene gene777 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00778 VSVS12_00779 VSVS12_00779 VSVS12_00779 841202 841735 - Non-canonical purine NTP phosphatase Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool%2C thus preventing their incorporation into DNA and avoiding chromosomal lesions%3B Belongs to the YjjX NTPase family gene gene778 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00779 VSVS12_00780 VSVS12_00780 VSVS12_00780 841701 844046 - Cyclic-guanylate-specific phosphodiesterase Plays an essential role in the maintenance and the formation of the three-dimensional structure of the biofilms at the later stages of their development. Absence of mbaA promotes the accumulation of larger amount of biomass on the surfaces at later stage of development%2C results in the overproduction of an extracellular polymeric substance that accumulates in the matrix of biofilms. This yields biofilms lacking the typical structure consisting of pillars of cells separated by fluid filled channels%3B Contains 1 EAL domain%3B Contains 1 GGDEF domain%3B Contains 1 HAMP domain%3B KEGG: bxe:Bxe_B1152 cyclic di-GMP phosphodiesterase Gmr gene gene779 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00780 VSVS12_00781 VSVS12_00781 VSVS12_00781 844030 845079 - Norspermidine sensor Acts as a sensor of norspermidine and enhances biofilm formation. When complexed to norspermidine%2C could interact with the periplasmic portion of MbaA to regulate its enzymatic activity%3B Belongs to the bacterial solute-binding protein PotD/PotF family gene gene780 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00781 VSVS12_00782 VSVS12_00782 pheA pheA 845239 846417 - Chorismate mutase Contains 1 ACT domain%3B Contains 1 chorismate mutase domain%3B Contains 1 prephenate dehydratase domain%3B KEGG: vch:VC0705 chorismate mutase / prephenate dehydratase gene gene781 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00782 VSVS12_00783 VSVS12_00783 VSVS12_00783 846658 846984 - Ribosome-associated inhibitor During stationary phase%2C prevents 70S dimer formation%2C probably in order to regulate translation efficiency during transition between the exponential and the stationary phases. In addition%2C during environmental stress such as cold shock or excessive cell density at stationary phase%2C stabilizes the 70S ribosome against dissociation%2C inhibits translation initiation and increase translation accuracy. When normal growth conditions are restored%2C is quickly released from the ribosome (By similarity)%3B Belongs to the Hpf/RaiA ribosome-associated protein family. RaiA subfamily gene gene782 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00783 VSVS12_00784 VSVS12_00784 VSVS12_00784 847332 848768 - hypothetical protein gene gene783 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00784 VSVS12_00785 VSVS12_00785 VSVS12_00785 848960 849370 + hypothetical protein gene gene784 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00785 VSVS12_00786 VSVS12_00786 VSVS12_00786 849469 850197 + Transposase InsF for insertion sequence IS3A Involved in the transposition of the insertion sequence IS3. Belongs to the transposase IS3/IS150/IS904 family%3B Contains 1 integrase catalytic domain gene gene785 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00786 VSVS12_00787 VSVS12_00787 VSVS12_00787 850237 850962 - Outer membrane protein assembly factor BamD Part of the outer membrane protein assembly complex%2C which is involved in assembly and insertion of beta-barrel proteins into the outer membrane%3B Belongs to the BamD family gene gene786 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00787 VSVS12_00788 VSVS12_00788 rluD rluD 851093 852070 + 23S rRNA pseudouridine(1911/1915/1917) synthase Responsible for synthesis of pseudouridine from uracil at positions 1911%2C 1915 and 1917 in 23S ribosomal RNA%3B Belongs to the pseudouridine synthase RluA family%3B Contains 1 S4 RNA-binding domain%3B KEGG: ype:YPO3277 23S rRNA pseudouridine1911/1915/1917 synthase gene gene787 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00788 VSVS12_00789 VSVS12_00789 VSVS12_00789 852072 852812 + Laccase domain protein Belongs to the LACC1 family gene gene788 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00789 VSVS12_00790 VSVS12_00790 VSVS12_00790 852943 855516 + Chaperone protein ClpB Part of a stress-induced multi-chaperone system%2C it is involved in the recovery of the cell from heat-induced damage%2C in cooperation with DnaK%2C DnaJ and GrpE. Acts before DnaK%2C in the processing of protein aggregates. Protein binding stimulates the ATPase activit%3B ATP hydrolysis unfolds the denatured protein aggregates%2C which probably helps expose new hydrophobic binding sites on the surface of ClpB-bound aggregates%2C contributing to the solubilization and refolding of denatured protein aggregates by DnaK (By similarity)%3B Belongs to the ClpA/ClpB family gene gene789 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00790 VSVS12_00791 VSVS12_00791 VSVS12_00791 856059 857605 + 16S ribosomal RNA rRNA gene790 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00791 VSVS12_00792 VSVS12_00792 VSVS12_00792 857700 857775 + tRNA-Glu tRNA gene791 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00792 VSVS12_00793 VSVS12_00793 VSVS12_00793 857793 857868 + tRNA-Ala tRNA gene792 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00793 VSVS12_00794 VSVS12_00794 VSVS12_00794 858210 861103 + 23S ribosomal RNA rRNA gene793 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00794 VSVS12_00795 VSVS12_00795 VSVS12_00795 861215 861329 + 5S ribosomal RNA rRNA gene794 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00795 VSVS12_00796 VSVS12_00796 VSVS12_00796 861399 861475 + tRNA-Asp tRNA gene795 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00796 VSVS12_00797 VSVS12_00797 VSVS12_00797 861511 861587 + tRNA-Trp tRNA gene796 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00797 VSVS12_00798 VSVS12_00798 VSVS12_00798 861692 862045 - uncharacterized protein gene gene797 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00798 VSVS12_00799 VSVS12_00799 VSVS12_00799 862239 862727 - hypothetical protein gene gene798 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00799 VSVS12_00800 VSVS12_00800 VSVS12_00800 863560 863892 + hypothetical protein gene gene799 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00800 VSVS12_00801 VSVS12_00801 VSVS12_00801 863937 864317 + hypothetical protein gene gene800 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00801 VSVS12_00802 VSVS12_00802 VSVS12_00802 864405 865133 - Transposase InsF for insertion sequence IS3A Involved in the transposition of the insertion sequence IS3. Belongs to the transposase IS3/IS150/IS904 family%3B Contains 1 integrase catalytic domain gene gene801 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00802 VSVS12_00803 VSVS12_00803 VSVS12_00803 865232 865642 - hypothetical protein gene gene802 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00803 VSVS12_00804 VSVS12_00804 impA impA 865748 866551 - Inositol-phosphate phosphatase Belongs to the inositol monophosphatase family%3B KEGG: eco:b2533 myo-inositol-1(or 4)-monophosphatase gene gene803 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00804 VSVS12_00805 VSVS12_00805 trmJ trmJ 866730 867455 + tRNA (cytidine(32)/uridine(32)-2'-O)-methyltransferase Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA%3B Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family%3B KEGG: eco:b2532 tRNA (cytidine32/uridine32-2'-O)-methyltransferase gene gene804 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00805 VSVS12_00806 VSVS12_00806 VSVS12_00806 867575 868081 + HTH-type transcriptional regulator CymR Master repressor of cysteine metabolism in B. subtilis. Controls the expression of genes involved either in cysteine synthesis from sulfide (cysK)%2C sulfonates (ssu)%2C or methionine (mccAB) or in cystine uptake (tcyP). Activity of CymR is positively regulated by CysK in response to cysteine availability. When cysteine is present%2C the pool of O-acetylserine (OAS) is low%2C which leads to the formation of a CymR-CysK complex and transcriptional repression of the CymR regulon occurs. In the absence of cysteine%2C the OAS pool is high and the CymR-CysK complex is mostly dissociated%2C leading to a faster dissociation of CymR from its DNA targets and the lifting of CymR-dependent repression%3B Contains 1 HTH rrf2-type DNA-binding domain gene gene805 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00806 VSVS12_00807 VSVS12_00807 iscS iscS 868112 869326 + Cysteine desulfurase Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly%2C tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU%2C an Fe-S scaffold assembly protein%2C as well as other S acceptor proteins%3B Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily%3B KEGG: eco:b2530 cysteine desulfurase gene gene806 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00807 VSVS12_00808 VSVS12_00808 VSVS12_00808 869377 869757 + Iron-sulfur cluster assembly scaffold protein IscU A scaffold on which IscS assembles Fe-S clusters. Cluster assembly on IscU homodimers proceeds sequentially from 1 2Fe-2S per dimer%2C to 2 2Fe-2S per dimer and finally 1 4Fe-4S per dimer. Subsequently IscU transfers the Fe-S cluster to other acceptor proteins. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters. The clusters are very sensitive to O(2)%3B Belongs to the NifU family gene gene807 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00808 VSVS12_00809 VSVS12_00809 VSVS12_00809 869825 870148 + Iron-binding protein IscA Is able to transfer iron-sulfur clusters to apo- ferredoxin. Multiple cycles of [2Fe2S] cluster formation and transfer are observed%2C suggesting that IscA acts catalytically. Recruits intracellular free iron so as to provide iron for the assembly of transient iron-sulfur cluster in IscU in the presence of IscS%2C L-cysteine and the thioredoxin reductase system TrxA/TrxB%3B Belongs to the HesB/IscA family gene gene808 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00809 VSVS12_00810 VSVS12_00810 VSVS12_00810 870202 870717 + Co-chaperone protein HscB like protein Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA%3B Belongs to the HscB family%3B Contains 1 J domain gene gene809 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00810 VSVS12_00811 VSVS12_00811 VSVS12_00811 870738 872591 + Chaperone protein HscA like protein Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB%3B Belongs to the heat shock protein 70 family gene gene810 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00811 VSVS12_00812 VSVS12_00812 VSVS12_00812 872603 872941 + 2Fe-2S ferredoxin Ferredoxin are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. Belongs to the adrenodoxin/putidaredoxin family%3B Contains 1 2Fe-2S ferredoxin-type domain gene gene811 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00812 VSVS12_00813 VSVS12_00813 VSVS12_00813 873040 873234 + Protein IscX May function as iron donor in the assembly of iron- sulfur clusters%3B Belongs to the IscX family gene gene812 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00813 VSVS12_00814 VSVS12_00814 pepB pepB 873433 874719 + PepB aminopeptidase Probably plays an important role in intracellular peptide degradation%3B Belongs to the peptidase M17 family%3B KEGG: vch:VC0755 PepB aminopeptidase gene gene813 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00814 VSVS12_00815 VSVS12_00815 VSVS12_00815 874789 875214 + Nucleoside-diphosphate kinase Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism%2C using a phosphorylated active-site intermediate%3B Belongs to the NDK family%3B KEGG: eco:b2518 nucleoside-diphosphate kinase gene gene814 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00815 VSVS12_00816 VSVS12_00816 sufS sufS 875304 876515 - Cysteine desulfurase Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine%2C L-cystine%2C L-selenocysteine%2C and L- selenocystine to produce L-alanine%3B Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily%3B KEGG: fph:Fphi_0125 cysteine desulfurase / selenocysteine lyase gene gene815 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00816 VSVS12_00817 VSVS12_00817 VSVS12_00817 876515 877114 - putative protein deglycase Protein deglycase that repairs methylglyoxal- and glyoxal-glycated amino acids and proteins%2C and releases repaired proteins and lactate or glycolate%2C respectively. Deglycates cysteines%2C arginines and lysines residues in proteins%2C and thus reactivates these proteins by reversing glycation by glyoxals. Acts on early glycation intermediates (hemithioacetals and aminocarbinols)%2C preventing the formation of advanced glycation endproducts (AGE) (PubMed:25416785) (By similarity). Displays a covalent chaperone activity with sulfenylated thiol proteins by forming mixed disulfides with members of the thiol proteome%2C and preferentially with sulfenylated cellular proteins%2C upon oxidative stres%3B these mixed disulfides can be subsequently reduced by low- molecular-weight thiols to regenerate YajL and reduced proteins (PubMed:22157000%2C PubMed:22321799). Involved in biogenesis of ribosomal proteins%2C probably as a ribosomal protein-folding chaperone. Confers resistance to oxidative stress. The chaperone activity reported for YajL is probably recruited to execute its deglycase activity%2C to interact with non-native glycated proteins and gain access to partially buried glycated sites%3B Belongs to the peptidase C56 family gene gene816 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00817 VSVS12_00818 VSVS12_00818 panE panE 877119 878000 - 2-dehydropantoate 2-reductase Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. Belongs to the ketopantoate reductase family%3B KEGG: vch:VC2307 2-dehydropantoate 2-reductase gene gene817 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00818 VSVS12_00819 VSVS12_00819 VSVS12_00819 878104 878946 - Outer membrane protein OmpK Serves as receptor for a broad-host-range vibriophage%2C KVP40%3B To E. coli tsx gene gene818 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00819 VSVS12_00820 VSVS12_00820 VSVS12_00820 879295 879867 + hypothetical protein gene gene819 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00820 VSVS12_00821 VSVS12_00821 VSVS12_00821 879924 880508 + ECF RNA polymerase sigma factor RpoE Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. Extracytoplasmic function (ECF) sigma factors are held in an inactive form by a cognate anti-sigma factor until released. Sigma-E controls a transcriptional response to singlet oxygen%2C a by-product of photosynthesi%3B its continuous activity requires constant exposure to singlet oxygen. The regulon has about 180 genes that protect against or repair damage induced by singlet oxygen%2C including itself and rpoH2%2C a heat shock- responsive sigma factor%3B Belongs to the sigma-70 factor family. ECF subfamily gene gene820 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00821 VSVS12_00822 VSVS12_00822 VSVS12_00822 880505 881167 + hypothetical protein gene gene821 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00822 VSVS12_00823 VSVS12_00823 VSVS12_00823 881228 882604 - Putative transporter AmpG Belongs to the major facilitator superfamily gene gene822 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00823 VSVS12_00824 VSVS12_00824 ppiA ppiA 882690 883235 - Peptidylprolyl isomerase PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. May be involved in pre-mRNA splicing (By similarity)%3B Belongs to the cyclophilin-type PPIase family. PPIL1 subfamily%3B Contains 1 PPIase cyclophilin-type domain%3B KEGG: vcy:IX92_12105 peptidyl-prolyl cis-trans isomerase A (cyclophilin A) gene gene823 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00824 VSVS12_00825 VSVS12_00825 VSVS12_00825 883235 883807 - hypothetical protein gene gene824 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00825 VSVS12_00826 VSVS12_00826 VSVS12_00826 883867 885087 - 16S rRNA (guanine(1207)-N(2))-methyltransferase Specifically methylates the guanine in position 1835 (m2G1835) of 23S rRNA%3B Belongs to the methyltransferase superfamily. RlmG family%3B KEGG: vvu:VV1_1819 16S rRNA (guanine1207-N2)-methyltransferase gene gene825 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00826 VSVS12_00827 VSVS12_00827 VSVS12_00827 885147 885452 + Protein BolA like protein Belongs to the BolA/IbaG family gene gene826 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00827 VSVS12_00828 VSVS12_00828 nqrA nqrA 885878 887218 + Na(+)-translocating NADH-quinone reductase subunit NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions%2C coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step%2C the conversion of ubisemiquinone to ubiquinol%3B Belongs to the NqrA family%3B KEGG: hin:HI0164 Na+-transporting NADH:ubiquinone oxidoreductase subunit A%3B With a quinone or similar compound as acceptor gene gene827 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00828 VSVS12_00829 VSVS12_00829 nqrB nqrB 887222 888463 + Na(+)-translocating NADH-quinone reductase subunit NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions%2C coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step%2C the conversion of ubisemiquinone to ubiquinol%3B Belongs to the NqrB/RnfD family%3B KEGG: vha:VIBHAR_03274 Na+-transporting NADH:ubiquinone oxidoreductase subunit B%3B With a quinone or similar compound as acceptor%3B overlaps another CDS with the same product name gene gene828 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00829 VSVS12_00830 VSVS12_00830 nqrC nqrC 888453 889238 + Na(+)-translocating NADH-quinone reductase subunit NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions%2C coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step%2C the conversion of ubisemiquinone to ubiquinol%3B Belongs to the NqrC family%3B KEGG: vch:VC2293 Na+-transporting NADH:ubiquinone oxidoreductase subunit C%3B With a quinone or similar compound as acceptor%3B overlaps another CDS with the same product name gene gene829 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00830 VSVS12_00831 VSVS12_00831 nqrD nqrD 889238 889870 + Na(+)-translocating NADH-quinone reductase subunit D NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions%2C coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step%2C the conversion of ubisemiquinone to ubiquinol%3B Belongs to the NqrDE/RnfAE family%3B KEGG: son:SO_1106 Na+-transporting NADH:ubiquinone oxidoreductase subunit D%3B With a quinone or similar compound as acceptor gene gene830 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00831 VSVS12_00832 VSVS12_00832 nqrE nqrE 889875 890474 + Na(+)-translocating NADH-quinone reductase subunit NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions%2C coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step%2C the conversion of ubisemiquinone to ubiquinol%3B Belongs to the NqrDE/RnfAE family%3B KEGG: hch:HCH_02689 Na+-transporting NADH:ubiquinone oxidoreductase subunit E%3B With a quinone or similar compound as acceptor gene gene831 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00832 VSVS12_00833 VSVS12_00833 nqrF nqrF 890504 891730 + Na(+)-translocating NADH-quinone reductase subunit NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions%2C coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF%2C which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway%3B Belongs to the NqrF family%3B Contains 1 2Fe-2S ferredoxin-type domain%3B Contains 1 FAD-binding FR-type domain%3B KEGG: vch:VC2290 Na+-transporting NADH:ubiquinone oxidoreductase subunit F%3B With a quinone or similar compound as acceptor gene gene832 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00833 VSVS12_00834 VSVS12_00834 VSVS12_00834 891982 892986 + FAD:protein FMN transferase Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein such as NqrB and NqrC%2C two subunits of the NQR complex. Cannot use directly FMN instead of FAD as substrate%3B Belongs to the ApbE family gene gene833 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00834 VSVS12_00835 VSVS12_00835 VSVS12_00835 893009 893242 + uncharacterized protein gene gene834 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00835 VSVS12_00836 VSVS12_00836 VSVS12_00836 893318 894532 - Two-component response regulator ORR11 Functions as response regulator involved in His-to-Asp phosphorelay signal transduction system. Phosphorylation of the Asp residue in the receiver domain activates the ability of the protein to promote the transcription of target genes. Type-A response regulators seem to act as negative regulators of the cytokinin signaling%3B Belongs to the ARR family. Type-A subfamily%3B Contains 1 response regulatory domain gene gene835 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00836 VSVS12_00837 VSVS12_00837 dpo4 dpo4 894683 895756 + DNA-directed DNA polymerase Poorly processive%2C error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks%2C which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis%2C in conjunction with the beta clamp from PolIII%3B Belongs to the DNA polymerase type-Y family%3B Contains 1 umuC domain%3B KEGG: pami:JCM7686_3234 DNA polymerase IV gene gene836 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00837 VSVS12_00838 VSVS12_00838 VSVS12_00838 895785 896342 + hypothetical protein gene gene837 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00838 VSVS12_00839 VSVS12_00839 VSVS12_00839 896404 897165 + hypothetical protein gene gene838 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00839 VSVS12_00840 VSVS12_00840 VSVS12_00840 897352 898713 + Sodium-dependent neutral amino acid transporter B(0)AT2 Functions as a sodium-dependent neutral amino acid transporter. Exhibits preference for methionine and for the branched-chain amino acids%2C particularly leucine%2C valine and isoleucine. Mediates the saturable%2C pH-sensitive and electrogenic cotransport of proline and sodium ions with a stoichiometry of 1:1. May have a role as transporter for neurotransmitter precursors into neurons. Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2. A. 22) family. SLC6A15 subfamily gene gene839 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00840 VSVS12_00841 VSVS12_00841 VSVS12_00841 898850 900181 + Transposase InsG for insertion sequence element IS4 Involved in the transposition of the insertion sequence IS4. Belongs to the transposase 11 family gene gene840 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00841 VSVS12_00842 VSVS12_00842 VSVS12_00842 900225 901289 - hypothetical protein gene gene841 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00842 VSVS12_00843 VSVS12_00843 rimK rimK 901276 902181 - putative alpha-L-glutamate ligase Belongs to the RimK family%3B Contains 1 ATP-grasp domain%3B KEGG: vch:VC2281 ribosomal protein S6--L-glutamate ligase%3B Acid--amino-acid ligases (peptide synthases)%3B overlaps another CDS with the same product name gene gene842 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00843 VSVS12_00844 VSVS12_00844 VSVS12_00844 902181 902624 - putative alpha-L-glutamate ligase In the C-terminal sectio%3B belongs to the RimK family%3B Contains 1 ATP-grasp domain%3B KEGG: sse:Ssed_3966 ribosomal protein S6--L-glutamate ligase%3B Acid--amino-acid ligases (peptide synthases)%3B overlaps another CDS with the same product name gene gene843 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00844 VSVS12_00845 VSVS12_00845 pepD pepD 903041 904513 - Cytosol non-specific dipeptidase Dipeptidase with broad substrate specificity. Requires dipeptide substrates with an unblocked N-terminus and the amino group in the alpha or beta position. Non-protein amino acids and proline are not accepted in the C-terminal position%2C whereas some dipeptide amides and formyl amino acids are hydrolyzed. Also shows cysteinylglycinase activity%2C which is sufficient for E. coli to utilize cysteinylglycine as a cysteine source%3B Belongs to the peptidase M20C family%3B KEGG: vvu:VV1_0333 dipeptidase D%3B Dipeptidases gene gene844 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00845 VSVS12_00846 VSVS12_00846 VSVS12_00846 905537 906826 + Adenine permease AdeP High-affinity transporter for adenine%3B Belongs to the xanthine/uracil permease family. AzgA purine transporter (TC 2. A. 1. 40) subfamily gene gene845 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00846 VSVS12_00847 VSVS12_00847 VSVS12_00847 907114 907578 + Xanthine phosphoribosyltransferase Acts on guanine%2C xanthine and to a lesser extent hypoxanthine%3B Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily%3B KEGG: bab:bbp232 xanthine phosphoribosyltransferase gene gene846 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00847 VSVS12_00848 VSVS12_00848 frsA frsA 907720 908967 + UPF0255 protein Belongs to the UPF0255 family%3B KEGG: van:VAA_03877 esterase FrsA%3B Acting on ester bonds gene gene847 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00848 VSVS12_00849 VSVS12_00849 VSVS12_00849 909051 909440 + Sigma factor-binding protein Crl Binds to the sigma-S subunit of RNA polymerase%2C activating expression of sigma-S-regulated genes. Stimulates RNA polymerase holoenzyme formation and may bind to several other sigma factors%2C such as sigma-70 and sigma-32%3B Belongs to the Crl family gene gene848 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00849 VSVS12_00850 VSVS12_00850 proB proB 909559 910698 + Glutamate 5-kinase Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate%3B Belongs to the glutamate 5-kinase family%3B Contains 1 PUA domain%3B KEGG: vpa:VP0676 glutamate 5-kinase gene gene849 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00850 VSVS12_00851 VSVS12_00851 proA proA 910734 911969 + Glutamate-5-semialdehyde dehydrogenase Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate%3B Belongs to the gamma-glutamyl phosphate reductase family%3B KEGG: ype:YPO3221 glutamate-5-semialdehyde dehydrogenase gene gene850 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00851 VSVS12_00852 VSVS12_00852 VSVS12_00852 912127 912576 + Transcriptional repressor NrdR Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes%3B Belongs to the NrdR family%3B Contains 1 ATP-cone domain gene gene851 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00852 VSVS12_00853 VSVS12_00853 ribD ribD 912589 913695 + Diaminohydroxyphosphoribosylaminopyrimidine deaminase Converts 2%2C5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2%2C4(1h%2C3h)- pyrimidinedione 5'-phosphate. In the N-terminal sectio%3B belongs to the cytidine and deoxycytidylate deaminase family%3B In the C-terminal sectio%3B belongs to the HTP reductase family%3B Contains 1 CMP/dCMP-type deaminase domain%3B KEGG: pmu:PM0749 diaminohydroxyphosphoribosylaminopyrimidine deaminase / 5-amino-6-(5-phosphoribosylamino)uracil reductase gene gene852 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00853 VSVS12_00854 VSVS12_00854 ribE ribE 913698 914351 + Riboflavin synthase Catalyzes the dismutation of two molecules of 6%2C7- dimethyl-8-ribityllumazine%2C resulting in the formation of riboflavin and 5-amino-6-(D-ribitylamino)uracil%3B Contains 2 lumazine-binding repeats%3B KEGG: bpn:BPEN_377 riboflavin synthase gene gene853 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00854 VSVS12_00855 VSVS12_00855 VSVS12_00855 914426 915535 + 3%2C4-dihydroxy-2-butanone-4-phosphate synthase Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3%2C4-dihydroxy-2-butanone 4-phosphate%3B In the N-terminal sectio%3B belongs to the DHBP synthase family%3B In the C-terminal sectio%3B belongs to the GTP cyclohydrolase II family%3B KEGG: vch:VC2269 3%2C4-dihydroxy 2-butanone 4-phosphate synthase / GTP cyclohydrolase II gene gene854 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00855 VSVS12_00856 VSVS12_00856 ribH ribH 915685 916155 + 6%2C7-dimethyl-8-ribityllumazine synthase Catalyzes the formation of 6%2C7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3%2C4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin%3B Belongs to the DMRL synthase family%3B KEGG: vch:VC2268 6%2C7-dimethyl-8-ribityllumazine synthase gene gene855 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00856 VSVS12_00857 VSVS12_00857 VSVS12_00857 916155 916622 + N utilization substance protein B like protein Involved in the transcription termination process%3B Belongs to the NusB family gene gene856 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00857 VSVS12_00858 VSVS12_00858 thiL thiL 916714 917685 + Thiamine-phosphate kinase Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP)%2C the active form of vitamin B1%3B Belongs to the thiamine-monophosphate kinase family%3B KEGG: eca:ECA1129 thiamine-monophosphate kinase gene gene857 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00858 VSVS12_00859 VSVS12_00859 pgpA pgpA 917695 918198 + Phosphatidylglycerophosphatase Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)%3B KEGG: vpa:VP0685 phosphatidylglycerophosphatase A gene gene858 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00859 VSVS12_00860 VSVS12_00860 VSVS12_00860 918341 918655 + hypothetical protein gene gene859 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00860 VSVS12_00861 VSVS12_00861 VSVS12_00861 918697 919512 + Transposase for insertion sequence element IS904 Involved in the transposition of the insertion sequence. Belongs to the transposase IS3/IS150/IS904 family%3B Contains 1 integrase catalytic domain gene gene860 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00861 VSVS12_00862 VSVS12_00862 VSVS12_00862 919572 919955 - UPF0325 protein Belongs to the UPF0325 family gene gene861 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00862 VSVS12_00863 VSVS12_00863 glnD glnD 920100 922724 - [Protein-PII] uridylyltransferase Under low glutamine levels%2C catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi%2C while under higher glutamine levels%2C GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus%2C controls uridylylation state and activity of the PII proteins%2C and plays an important role in the regulation of nitrogen assimilation and metabolism%3B Belongs to the GlnD family%3B Contains 2 ACT domains%3B Contains 1 HD domain%3B KEGG: vch:VC2262 (protein-PII) uridylyltransferase gene gene862 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00863 VSVS12_00864 VSVS12_00864 VSVS12_00864 922814 923692 - Methionyl aminopeptidase Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-%2C Cys%2C Gly%2C Pro%2C Ser%2C Thr%2C or Val)%3B Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily%3B KEGG: psts:E05_24480 methionyl aminopeptidase gene gene863 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00864 VSVS12_00865 VSVS12_00865 VSVS12_00865 924084 924812 + 30S ribosomal protein S2 Belongs to the ribosomal protein S2P family gene gene864 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00865 VSVS12_00866 VSVS12_00866 VSVS12_00866 924936 925781 + Elongation factor Ts Associates with the EF-Tu. GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA. EF- Tu. GTP complex up to the GTP hydrolysis stage on the ribosome%3B Belongs to the EF-Ts family gene gene865 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00866 VSVS12_00867 VSVS12_00867 pyrH pyrH 925934 926665 + UMP kinase Catalyzes the reversible phosphorylation of UMP to UDP%3B Belongs to the UMP kinase family%3B KEGG: vch:VC2258 uridylate kinase gene gene866 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00867 VSVS12_00868 VSVS12_00868 VSVS12_00868 926775 927332 + Ribosome-recycling factor Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another%3B Belongs to the RRF family gene gene867 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00868 VSVS12_00869 VSVS12_00869 uppS uppS 927426 928181 + Ditrans%2Cpolycis-undecaprenyl-diphosphate synthase ((2E%2C6E)-farnesyl-diphosphate specific) Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E%2C6E)-farnesyl diphosphate (E%2CE-FPP) to yield (2Z%2C6Z%2C10Z%2C14Z%2C18Z%2C22Z%2C26Z%2C30Z%2C34E%2C38E)-undecaprenyl diphosphate (di-trans%2Cocta-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide%3B Belongs to the UPP synthase family%3B KEGG: vni:VIBNI_A2500 undecaprenyl diphosphate synthase gene gene868 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00869 VSVS12_00870 VSVS12_00870 cds1 cds1 928192 929034 + Phosphatidate cytidylyltransferase Belongs to the CDS family%3B KEGG: hiz:R2866_1464 phosphatidate cytidylyltransferase gene gene869 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00870 VSVS12_00871 VSVS12_00871 VSVS12_00871 929080 930288 + 1-deoxy-D-xylulose-5-phosphate reductoisomerase Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)%3B Belongs to the DXR family%3B KEGG: plu:plu0676 1-deoxy-D-xylulose-5-phosphate reductoisomerase gene gene870 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00871 VSVS12_00872 VSVS12_00872 rseP rseP 930285 931643 + Putative zinc metalloprotease Belongs to the peptidase M50B family%3B Contains 1 PDZ (DHR) domain%3B KEGG: vsp:VS_2345 regulator of sigma E protease%3B Metalloendopeptidases gene gene871 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00872 VSVS12_00873 VSVS12_00873 VSVS12_00873 931683 934085 + Outer membrane protein assembly factor BamA Part of the outer membrane protein assembly complex%2C which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. Constitutes%2C with BamD%2C the core component of the assembly machinery%3B Belongs to the BamA family%3B Contains 5 POTRA domains gene gene872 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00873 VSVS12_00874 VSVS12_00874 VSVS12_00874 934100 934609 + Chaperone protein Skp Molecular chaperone that interacts specifically with outer membrane proteins%2C thus maintaining the solubility of early folding intermediates during passage through the periplasm%3B Belongs to the Skp family gene gene873 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00874 VSVS12_00875 VSVS12_00875 lpxD lpxD 934616 935647 + UDP-3-O-(3-hydroxymyristoyl)glucosamine N-acyltransferase Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A%2C a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell%3B Belongs to the transferase hexapeptide repeat family. LpxD subfamily%3B KEGG: ssz:SCc_215 UDP-3-O-(3-hydroxymyristoyl) glucosamine N-acyltransferase gene gene874 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00875 VSVS12_00876 VSVS12_00876 fabZ fabZ 935799 936251 + 3-hydroxyacyl-[acyl-carrier-protein] dehydratase Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs%3B Belongs to the thioester dehydratase family. FabZ subfamily%3B KEGG: vch:VC2249 3-hydroxyacyl-(acyl-carrier-protein) dehydratase gene gene875 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00876 VSVS12_00877 VSVS12_00877 lpxA lpxA 936253 937041 + Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase Involved in the biosynthesis of lipid A%2C a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell%3B Belongs to the transferase hexapeptide repeat family. LpxA subfamily%3B KEGG: vch:VC2248 UDP-N-acetylglucosamine acyltransferase gene gene876 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00877 VSVS12_00878 VSVS12_00878 lpxB lpxB 937121 938272 + Lipid-A-disaccharide synthase Condensation of UDP-2%2C3-diacylglucosamine and 2%2C3- diacylglucosamine-1-phosphate to form lipid A disaccharide%2C a precursor of lipid A%2C a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell%3B Belongs to the LpxB family%3B KEGG: ssz:SCc_218 lipid-A-disaccharide synthase gene gene877 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00878 VSVS12_00879 VSVS12_00879 rnhB rnhB 938269 938898 + Ribonuclease H Endonuclease that specifically degrades the RNA of RNA- DNA hybrids%3B Belongs to the RNase HII family%3B KEGG: vcy:IX92_11835 ribonuclease HII gene gene878 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00879 VSVS12_00880 VSVS12_00880 dnaE dnaE 938954 942433 + DNA-directed DNA polymerase DNA polymerase III is a complex%2C multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The alpha chain is the DNA polymerase (By similarity)%3B Belongs to the DNA polymerase type-C family. DnaE subfamily%3B KEGG: eco:b0184 DNA polymerase III subunit alpha gene gene879 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00880 VSVS12_00881 VSVS12_00881 accA accA 942471 943430 + Acetyl-CoA carboxylase Component of the acetyl coenzyme A carboxylase (ACC) complex. First%2C biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA%3B Belongs to the AccA family%3B KEGG: eco:b0185 acetyl-CoA carboxylase carboxyl transferase subunit alpha gene gene880 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00881 VSVS12_00882 VSVS12_00882 tilS tilS 943526 944836 + tRNA(Ile)-lysidine synthetase Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU%2C in an ATP-dependent manner. Cytidine is converted to lysidine%2C thus changing the amino acid specificity of the tRNA from methionine to isoleucine%3B Belongs to the tRNA(Ile)-lysidine synthase family%3B KEGG: mmb:Mmol_1287 tRNA(Ile)-lysidine synthase gene gene881 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00882 VSVS12_00883 VSVS12_00883 VSVS12_00883 944912 945250 + Nitrogen regulatory protein P-II In nitrogen-limiting conditions%2C when the ratio of Gln to 2-ketoglutarate decreases%2C P-II is uridylylated to P-II-UMP. P- II-UMP allows the deadenylation of glutamine synthetase (GS)%2C thus activating the enzyme. Conversely%2C in nitrogen excess P-II is deuridylated and promotes the adenylation of GS. P-II indirectly controls the transcription of the GS gene (glnA). P-II prevents NR-II-catalyzed conversion of NR-I to NR-I-phosphate%2C the transcriptional activator of glnA. When P-II is uridylylated to P- II-UMP%2C these events are reversed (By similarity)%3B Belongs to the P(II) protein family gene gene882 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00883 VSVS12_00884 VSVS12_00884 VSVS12_00884 945370 946260 + UPF0294 protein Belongs to the UPF0294 family gene gene883 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00884 VSVS12_00885 VSVS12_00885 VSVS12_00885 946246 946932 - hypothetical protein gene gene884 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00885 VSVS12_00886 VSVS12_00886 VSVS12_00886 946929 948500 - Membrane-bound lytic murein transglycosylase D Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division (By similarity)%3B Belongs to the transglycosylase Slt family%3B Contains 2 LysM repeats gene gene885 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00886 VSVS12_00887 VSVS12_00887 gloB gloB 948571 949329 - Hydroxyacylglutathione hydrolase Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid%3B Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family%3B KEGG: vch:VC2236 hydroxyacylglutathione hydrolase gene gene886 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00887 VSVS12_00888 VSVS12_00888 VSVS12_00888 949363 950109 + uncharacterized protein gene gene887 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00888 VSVS12_00889 VSVS12_00889 rnhA rnhA 950173 950640 - Ribonuclease H Endonuclease that specifically degrades the RNA of RNA- DNA hybrids%3B Belongs to the RNase H family%3B Contains 1 RNase H domain%3B KEGG: eco:b0214 ribonuclease HI gene gene888 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00889 VSVS12_00890 VSVS12_00890 dnaQ dnaQ 950697 951440 + DNA-directed DNA polymerase KEGG: vvu:VV1_1887 DNA polymerase III subunit epsilon gene gene889 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00890 VSVS12_00891 VSVS12_00891 VSVS12_00891 951449 952735 + hypothetical protein gene gene890 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00891 VSVS12_00892 VSVS12_00892 VSVS12_00892 952893 954224 + Transposase InsG for insertion sequence element IS4 Involved in the transposition of the insertion sequence IS4. Belongs to the transposase 11 family gene gene891 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00892 VSVS12_00893 VSVS12_00893 fadE fadE 954290 956737 - Acyl-coenzyme A dehydrogenase Catalyzes the dehydrogenation of acyl-CoA%3B Belongs to the acyl-CoA dehydrogenase family%3B KEGG: vch:VC2231 acyl-CoA dehydrogenase%3B With other acceptors gene gene892 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00893 VSVS12_00894 VSVS12_00894 gmhA gmhA 957072 957650 + D-sedoheptulose 7-phosphate isomerase Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate%3B Belongs to the SIS family. GmhA subfamily%3B Contains 1 SIS domain%3B KEGG: yep:YE105_C1039 D-sedoheptulose 7-phosphate isomerase gene gene893 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00894 VSVS12_00895 VSVS12_00895 VSVS12_00895 957735 958583 + Putative glutamine amidotransferase YafJ Contains 1 glutamine amidotransferase type-2 domain gene gene894 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00895 VSVS12_00896 VSVS12_00896 VSVS12_00896 958414 959298 - hypothetical protein gene gene895 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00896 VSVS12_00897 VSVS12_00897 parS parS 959522 961237 - Proline--tRNA ligase Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine%2C to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS%3B Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily%3B KEGG: eco:b0194 prolyl-tRNA synthetase gene gene896 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00897 VSVS12_00898 VSVS12_00898 VSVS12_00898 961347 962042 - putative tRNA (adenine(37)-N6)-methyltransferase Is likely the methyltransferase responsible for the addition of the methyl group in the formation of N6-methyl-N6- threonylcarbamoyladenosine at position 37 (m6t6A37) in some tRNAs species that read codons starting with adenosine. The methyl group of m6t6A37 appears to slightly improve the efficiency of the tRNA. Contains 1 TsaA-like domain gene gene897 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00898 VSVS12_00899 VSVS12_00899 VSVS12_00899 962198 962455 + 50S ribosomal protein L31 type Belongs to the ribosomal protein L31P family. Type B subfamily gene gene898 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00899 VSVS12_00900 VSVS12_00900 VSVS12_00900 962452 962577 + 50S ribosomal protein L36 Belongs to the ribosomal protein L36P family gene gene899 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00900 VSVS12_00901 VSVS12_00901 VSVS12_00901 962692 963501 - putative D-methionine-binding lipoprotein MetQ This protein is a component of a D-methionine permease%2C a binding protein-dependent%2C ATP-driven transport system%3B Belongs to the NlpA lipoprotein family gene gene900 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00901 VSVS12_00902 VSVS12_00902 VSVS12_00902 963525 964202 - putative D-methionine transport system permease protein MetI Part of the binding-protein-dependent transport system for D-methionine. Probably responsible for the translocation of the substrate across the membrane (By similarity)%3B Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily%3B Contains 1 ABC transmembrane type-1 domain gene gene901 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00902 VSVS12_00903 VSVS12_00903 VSVS12_00903 964192 965226 - Lipoprotein-releasing system ATP-binding protein LolD Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins%2C from the inner membrane to the periplasmic chaperone%2C LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner%3B Belongs to the ABC transporter superfamily. Lipoprotein translocase (TC 3. A. 1. 125) family%3B Contains 1 ABC transporter domain gene gene902 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00903 VSVS12_00904 VSVS12_00904 gmhB gmhB 965449 966000 + D-glycero-beta-D-manno-heptose 1%2C7-bisphosphate 7-phosphatase Converts the D-glycero-beta-D-manno-heptose 1%2C7- bisphosphate intermediate into D-glycero-beta-D-manno-heptose 1- phosphate by removing the phosphate group at the C-7 position%3B Belongs to the GmhB family%3B KEGG: vch:VC0908 D-glycero-D-manno-heptose 1%2C7-bisphosphate phosphatase gene gene903 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00904 VSVS12_00905 VSVS12_00905 VSVS12_00905 966052 966405 + hypothetical protein gene gene904 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00905 VSVS12_00906 VSVS12_00906 VSVS12_00906 966521 967156 - hypothetical protein gene gene905 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00906 VSVS12_00907 VSVS12_00907 glyA glyA 967455 968705 + Glycine hydroxymethyltransferase Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines%2C thymidylate%2C methionine%2C and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids%2C producing glycine and aldehydes%2C via a retro-aldol mechanism%3B Belongs to the SHMT family%3B KEGG: eco:b2551 glycine hydroxymethyltransferase gene gene906 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00907 VSVS12_00908 VSVS12_00908 VSVS12_00908 968923 969249 - hypothetical protein gene gene907 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00908 VSVS12_00909 VSVS12_00909 lipA lipA 969480 970445 - Lipoyl synthase Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes%2C thereby converting the octanoylated domains into lipoylated derivatives%3B Belongs to the radical SAM superfamily. Lipoyl synthase family%3B KEGG: eco:b0628 lipoic acid synthetase gene gene908 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00909 VSVS12_00910 VSVS12_00910 lipB lipB 970453 971106 - Lipoyl(octanoyl) transferase Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate%3B Belongs to the LipB family%3B Contains 1 BPL/LPL catalytic domain%3B KEGG: sgl:SG0793 lipoyl(octanoyl) transferase gene gene909 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00910 VSVS12_00911 VSVS12_00911 VSVS12_00911 971285 971563 - UPF0250 protein Belongs to the UPF0250 family gene gene910 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00911 VSVS12_00912 VSVS12_00912 dacC dacC 971708 972886 - Serine-type D-Ala-D-Ala carboxypeptidase Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors. Belongs to the peptidase S11 family%3B KEGG: vcy:IX92_11620 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 5/6) gene gene911 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00912 VSVS12_00913 VSVS12_00913 VSVS12_00913 972976 973812 - RlpA-like lipoprotein Belongs to the RlpA family%3B Contains 1 SPOR domain gene gene912 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00913 VSVS12_00914 VSVS12_00914 VSVS12_00914 973812 974933 - Rod shape-determining protein RodA Required for the maintenance of the rod cell shape. Required for the expression of the enzymatic activity of the penicillin-binding protein 2 (PBP2) (By similarity)%3B Belongs to the SEDS family. RodA subfamily gene gene913 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00914 VSVS12_00915 VSVS12_00915 VSVS12_00915 974933 976816 - Penicillin-binding protein Cell wall formatio%3B PBP-2 is responsible for the determination of the rod shape of the cell. Its synthesize cross- linked peptidoglycan from the lipid intermediates (By similarity)%3B Belongs to the transpeptidase family gene gene914 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00915 VSVS12_00916 VSVS12_00916 rlmH rlmH 976823 977293 - 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA%3B Belongs to the RNA methyltransferase RlmH family%3B KEGG: eco:b0636 23S rRNA (pseudouridine1915-N3)-methyltransferase gene gene915 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00916 VSVS12_00917 VSVS12_00917 VSVS12_00917 977297 977614 - Ribosomal silencing factor RsfS Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN)%2C blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes%2C thus repressing translation%3B Belongs to the Iojap/RsfS family gene gene916 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00917 VSVS12_00918 VSVS12_00918 holA holA 977680 978693 - DNA-directed DNA polymerase DNA polymerase III is a complex%2C multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The delta subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA (By similarity)%3B KEGG: vch:VC0953 DNA polymerase III subunit delta gene gene917 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00918 VSVS12_00919 VSVS12_00919 VSVS12_00919 978702 979364 - LPS-assembly lipoprotein LptE Together with LptD%2C is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane%3B Belongs to the LptE lipoprotein family gene gene918 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00919 VSVS12_00920 VSVS12_00920 VSVS12_00920 979527 982103 - Leucine--tRNA ligase Belongs to the class-I aminoacyl-tRNA synthetase family%3B KEGG: eco:b0642 leucyl-tRNA synthetase gene gene919 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00920 VSVS12_00921 VSVS12_00921 VSVS12_00921 982351 982821 + uncharacterized protein gene gene920 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00921 VSVS12_00922 VSVS12_00922 VSVS12_00922 982864 984378 - Apolipoprotein N-acyltransferase Transfers the fatty acyl group on membrane lipoproteins%3B Belongs to the CN hydrolase family. Apolipoprotein N- acyltransferase subfamily%3B Contains 1 CN hydrolase domain%3B KEGG: vch:VC0958 apolipoprotein N-acyltransferase%3B Transferring groups other than amino-acyl groups gene gene921 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00922 VSVS12_00923 VSVS12_00923 VSVS12_00923 984409 985308 - Magnesium and cobalt efflux protein CorC Plays a role in the transport of magnesium and cobalt ions%3B Belongs to the UPF0053 family%3B Contains 2 CBS domains gene gene922 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00923 VSVS12_00924 VSVS12_00924 VSVS12_00924 985411 985875 - Endoribonuclease YbeY Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA%3B Belongs to the endoribonuclease YbeY family gene gene923 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00924 VSVS12_00925 VSVS12_00925 VSVS12_00925 985875 986972 - PhoH-like protein Belongs to the PhoH family gene gene924 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00925 VSVS12_00926 VSVS12_00926 miaB miaB 987086 988510 - tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A)%2C leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine%3B Belongs to the methylthiotransferase family. MiaB subfamily%3B Contains 1 MTTase N-terminal domain%3B Contains 1 TRAM domain%3B KEGG: eco:b0661 tRNA-2-methylthio-N6-dimethylallyladenosine synthase gene gene925 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00926 VSVS12_00927 VSVS12_00927 ubiF ubiF 988779 989930 + 2-octaprenyl-3-methyl-6-methoxy-1%2C4-benzoquinol hydroxylase Oxygenase that introduces the hydroxyl group at carbon five of 2-octaprenyl-3-methyl-6-methoxy-1%2C4-benzoquinol resulting in the formation of 2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1%2C4- benzoquinol. Belongs to the UbiH/COQ6 family%3B KEGG: vvu:VV1_0265 2-octaprenyl-3-methyl-6-methoxy-1%2C4-benzoquinol hydroxylase%3B With NADH or NADPH as one donor%2C and incorporation of one atom of oxygen gene gene926 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00927 VSVS12_00928 VSVS12_00928 VSVS12_00928 990017 990526 - Protein-N(pi)-phosphohistidine--sugar phosphotransferase The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS)%2C a major carbohydrate active -transport system%2C catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in glucose transport (By similarity)%3B Contains 1 PTS EIIA type-1 domain%3B KEGG: eco:b2417 PTS system%2C glucose-specific IIA component gene gene927 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00928 VSVS12_00929 VSVS12_00929 ptsI ptsI 990732 992456 - Phosphoenolpyruvate--protein phosphotransferase General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity)%3B Belongs to the PEP-utilizing enzyme family%3B KEGG: eco:b2416 phosphotransferase system%2C enzyme I%2C PtsI gene gene928 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00929 VSVS12_00930 VSVS12_00930 VSVS12_00930 992496 992669 + hypothetical protein gene gene929 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00930 VSVS12_00931 VSVS12_00931 VSVS12_00931 992593 992850 - HPr-like protein Crh Involved in carbon catabolite repression (CCR)%3B Belongs to the HPr family%3B Contains 1 HPr domain gene gene930 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00931 VSVS12_00932 VSVS12_00932 cysK cysK 993152 994120 - Cysteine synthase Belongs to the cysteine synthase/cystathionine beta- synthase family%3B KEGG: eco:b2414 cysteine synthase A gene gene931 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00932 VSVS12_00933 VSVS12_00933 VSVS12_00933 994314 995066 - Sulfate transporter CysZ High affinity%2C high specificity proton-dependent sulfate transporter%2C which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway%3B Belongs to the CysZ family gene gene932 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00933 VSVS12_00934 VSVS12_00934 VSVS12_00934 995281 996345 + Cell division protein ZipA Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring. Also required for the recruitment to the septal ring of downstream cell division proteins%3B Belongs to the ZipA family gene gene933 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00934 VSVS12_00935 VSVS12_00935 ligA ligA 996537 998546 + DNA ligase (NAD(+)) DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA%3B Belongs to the NAD-dependent DNA ligase family. LigA subfamily%3B Contains 1 BRCT domain%3B KEGG: vtu:IX91_11535 DNA ligase (NAD+) gene gene934 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00935 VSVS12_00936 VSVS12_00936 VSVS12_00936 999052 1000155 + Chitoporin Involved in the uptake of chitosugars%3B Belongs to the Gram-negative porin family gene gene935 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00936 VSVS12_00937 VSVS12_00937 VSVS12_00937 1000235 1000867 + hypothetical protein gene gene936 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00937 VSVS12_00938 VSVS12_00938 VSVS12_00938 1000938 1001123 - hypothetical protein gene gene937 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00938 VSVS12_00939 VSVS12_00939 VSVS12_00939 1001368 1001817 - Inner membrane protein YbbJ To M. jannaschii MJ0826 gene gene938 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00939 VSVS12_00940 VSVS12_00940 hflK hflK 1001858 1002778 - Protein QmcA Belongs to the band 7/mec-2 family%3B KEGG: tde:TDE1332 membrane protease subunit HflK%3B Acting on peptide bonds (peptidases) gene gene939 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00940 VSVS12_00941 VSVS12_00941 VSVS12_00941 1002931 1003785 - Thioredoxin Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. Belongs to the thioredoxin family%3B Contains 1 thioredoxin domain gene gene940 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00941 VSVS12_00942 VSVS12_00942 VSVS12_00942 1004111 1004938 - putative oxidoreductase YbbO Belongs to the short-chain dehydrogenases/reductases (SDR) family%3B KEGG: ype:YPO3081 null%3B Oxidoreductases gene gene941 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00942 VSVS12_00943 VSVS12_00943 VSVS12_00943 1004990 1005904 - Protein Rcp Belongs to the NAD(P)-dependent epimerase/dehydratase family gene gene942 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00943 VSVS12_00944 VSVS12_00944 VSVS12_00944 1006136 1006882 + hypothetical protein gene gene943 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00944 VSVS12_00945 VSVS12_00945 VSVS12_00945 1006879 1007664 + hypothetical protein gene gene944 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00945 VSVS12_00946 VSVS12_00946 VSVS12_00946 1007654 1008004 + hypothetical protein gene gene945 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00946 VSVS12_00947 VSVS12_00947 guaB guaB 1008001 1008408 + IMP dehydrogenase Contains 2 CBS domains%3B KEGG: bma:BMAA1350 IMP dehydrogenase gene gene946 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00947 VSVS12_00948 VSVS12_00948 VSVS12_00948 1008456 1009013 + Phosphodiesterase Shows phosphodiesterase activity%3B Belongs to the metallophosphoesterase superfamily. YfcE family gene gene947 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00948 VSVS12_00949 VSVS12_00949 VSVS12_00949 1009205 1009483 - hypothetical protein gene gene948 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00949 VSVS12_00950 VSVS12_00950 VSVS12_00950 1009492 1010283 - UPF0721 transmembrane protein Belongs to the UPF0721 family gene gene949 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00950 VSVS12_00951 VSVS12_00951 VSVS12_00951 1010295 1010810 - Transmembrane regulatory protein ToxS Interacts with ToxR and stimulates its activity gene gene950 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00951 VSVS12_00952 VSVS12_00952 VSVS12_00952 1010820 1011692 - Cholera toxin like protein transcriptional activator In the presence of ToxS%2C promotes the expression of the thermostable direct hemolysin 2. May be a global regulator. Contains 1 OmpR/PhoB-type DNA-binding domain gene gene951 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00952 VSVS12_00953 VSVS12_00953 VSVS12_00953 1011957 1013861 + Chaperone protein HtpG Molecular chaperone. Has ATPase activity%3B Belongs to the heat shock protein 90 family gene gene952 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00953 VSVS12_00954 VSVS12_00954 VSVS12_00954 1014209 1014853 + Adenylate kinase Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Plays a major role in the equilibration of adenylates and de novo synthesis of ADP in the plastid stroma%3B Belongs to the adenylate kinase family%3B KEGG: eco:b0474 adenylate kinase gene gene953 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00954 VSVS12_00955 VSVS12_00955 hemH hemH 1015002 1015958 + Protoporphyrin ferrochelatase Catalyzes the ferrous insertion into protoporphyrin IX%3B Belongs to the ferrochelatase family%3B KEGG: vag:N646_2975 ferrochelatase gene gene954 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00955 VSVS12_00956 VSVS12_00956 VSVS12_00956 1016480 1017145 + hypothetical protein gene gene955 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00956 VSVS12_00957 VSVS12_00957 VSVS12_00957 1017220 1017663 - hypothetical protein gene gene956 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00957 VSVS12_00958 VSVS12_00958 copA copA 1017672 1020419 - Cu(+) exporting ATPase Involved in copper export%3B Belongs to the cation transport ATPase (P-type) (TC 3. A. 3) family. Type IB subfamily%3B Contains 3 HMA domains%3B KEGG: van:VAA_03537 Cu+-exporting ATPase gene gene957 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00958 VSVS12_00959 VSVS12_00959 VSVS12_00959 1020899 1021978 + Chitoporin Involved in the uptake of chitosugars%3B Belongs to the Gram-negative porin family gene gene958 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00959 VSVS12_00960 VSVS12_00960 VSVS12_00960 1022049 1022702 + hypothetical protein gene gene959 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00960 VSVS12_00961 VSVS12_00961 earS earS 1022871 1024295 + Glutamate--tRNA ligase Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)%3B Belongs to the class-I aminoacyl-tRNA synthetase family%3B KEGG: eco:b2400 glutamyl-tRNA synthetase gene gene960 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00961 VSVS12_00962 VSVS12_00962 VSVS12_00962 1024709 1025671 + Outer membrane protein A Required for the action of colicins K and L and for the stabilization of mating aggregates in conjugation. Serves as a receptor for a number of T-even like phages. Also acts as a porin with low permeability that allows slow penetration of small solutes (By similarity)%3B Belongs to the OmpA family%3B Contains 1 OmpA-like domain gene gene961 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00962 VSVS12_00963 VSVS12_00963 VSVS12_00963 1025758 1026264 - hypothetical protein gene gene962 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00963 VSVS12_00964 VSVS12_00964 VSVS12_00964 1026559 1026635 - tRNA-Arg tRNA gene963 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00964 VSVS12_00965 VSVS12_00965 VSVS12_00965 1026689 1027825 - hypothetical protein gene gene964 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00965 VSVS12_00966 VSVS12_00966 VSVS12_00966 1027989 1028624 + hypothetical protein gene gene965 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00966 VSVS12_00967 VSVS12_00967 VSVS12_00967 1028633 1029064 + hypothetical protein gene gene966 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00967 VSVS12_00968 VSVS12_00968 VSVS12_00968 1029152 1029577 - hypothetical protein gene gene967 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00968 VSVS12_00969 VSVS12_00969 VSVS12_00969 1029591 1029908 - hypothetical protein gene gene968 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00969 VSVS12_00970 VSVS12_00970 VSVS12_00970 1030027 1030773 - hypothetical protein gene gene969 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00970 VSVS12_00971 VSVS12_00971 VSVS12_00971 1030852 1031778 + Chemotaxis protein CheV Involved in the transmission of sensory signals from the chemoreceptors to the flagellar motors. Chemotaxis involves both a phosphorylation-dependent excitation and a methylation-dependent adaptation. CheV and CheW are involved in the coupling of the methyl-accepting chemoreceptors to the central two-component kinase Che%3B they are both necessary for efficient chemotaxis. Moreover%2C CheA-dependent phosphorylation of CheV is required for adaptation to attractants during B. subtilis chemotaxis%3B Contains 1 cheW-like domain%3B Contains 1 response regulatory domain gene gene970 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00971 VSVS12_00972 VSVS12_00972 cheR cheR 1031789 1032616 + Protein-glutamate O-methyltransferase Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP%3B Contains 1 cheR-type methyltransferase domain%3B KEGG: vch:VC2201 chemotaxis protein methyltransferase CheR gene gene971 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00972 VSVS12_00973 VSVS12_00973 VSVS12_00973 1032865 1033260 + Flagellar basal body rod protein FlgB Structural component of flagellum%2C the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity)%3B Belongs to the flagella basal body rod proteins family gene gene972 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00973 VSVS12_00974 VSVS12_00974 VSVS12_00974 1033265 1033681 + Flagellar basal-body rod protein Belongs to the flagella basal body rod proteins family gene gene973 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00974 VSVS12_00975 VSVS12_00975 VSVS12_00975 1033699 1034406 + Basal-body rod modification protein FlgD Required for flagellar hook formation. May act as a scaffolding protein (By similarity)%3B Belongs to the FlgD family gene gene974 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00975 VSVS12_00976 VSVS12_00976 VSVS12_00976 1034435 1035739 + Flagellar hook protein FlgE Belongs to the flagella basal body rod proteins family gene gene975 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00976 VSVS12_00977 VSVS12_00977 VSVS12_00977 1035949 1036698 + Flagellar basal-body rod protein Belongs to the flagella basal body rod proteins family gene gene976 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00977 VSVS12_00978 VSVS12_00978 VSVS12_00978 1036718 1037506 + Flagellar basal-body rod protein FlgG Belongs to the flagella basal body rod proteins family gene gene977 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00978 VSVS12_00979 VSVS12_00979 VSVS12_00979 1037562 1038350 + Flagellar L-ring protein Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation%3B Belongs to the FlgH family gene gene978 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00979 VSVS12_00980 VSVS12_00980 VSVS12_00980 1038401 1039492 + Flagellar P-ring protein Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation%3B Belongs to the FlgI family gene gene979 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00980 VSVS12_00981 VSVS12_00981 VSVS12_00981 1039503 1040426 + Peptidoglycan hydrolase FlgJ Flagellum-specific muramidase which hydrolyzes the peptidoglycan layer to assemble the rod structure in the periplasmic space%3B In the N-terminal sectio%3B belongs to the FlgJ family%3B In the C-terminal sectio%3B belongs to the glycosyl hydrolase 73 family gene gene980 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00981 VSVS12_00982 VSVS12_00982 VSVS12_00982 1040738 1042612 + Flagellar hook-associated protein Belongs to the flagella basal body rod proteins family gene gene981 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00982 VSVS12_00983 VSVS12_00983 VSVS12_00983 1042622 1043815 + Flagellar hook-associated protein Belongs to the bacterial flagellin family gene gene982 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00983 VSVS12_00984 VSVS12_00984 VSVS12_00984 1044180 1045319 + Flagellin Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella. FlaA is required to form a core or scaffold into which the other flagellins are inserted to provide structural integrity. Essential for flagellar synthesis and motilit%3B important for full virulence. Belongs to the bacterial flagellin family gene gene983 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00984 VSVS12_00985 VSVS12_00985 VSVS12_00985 1046004 1047140 + Flagellin Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella. FlaA is required to form a core or scaffold into which the other flagellins are inserted to provide structural integrity. Essential for flagellar synthesis and motilit%3B important for full virulence. Belongs to the bacterial flagellin family gene gene984 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00985 VSVS12_00986 VSVS12_00986 VSVS12_00986 1047345 1047429 - tRNA-Leu tRNA gene985 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00986 VSVS12_00987 VSVS12_00987 VSVS12_00987 1047507 1047581 - tRNA-Gln tRNA gene986 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00987 VSVS12_00988 VSVS12_00988 VSVS12_00988 1047615 1047699 - tRNA-Leu tRNA gene987 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00988 VSVS12_00989 VSVS12_00989 VSVS12_00989 1047777 1047851 - tRNA-Gln tRNA gene988 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00989 VSVS12_00990 VSVS12_00990 VSVS12_00990 1047885 1047969 - tRNA-Leu tRNA gene989 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00990 VSVS12_00991 VSVS12_00991 VSVS12_00991 1048047 1048121 - tRNA-Gln tRNA gene990 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00991 VSVS12_00992 VSVS12_00992 VSVS12_00992 1048190 1048274 - tRNA-Leu tRNA gene991 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00992 VSVS12_00993 VSVS12_00993 VSVS12_00993 1048355 1048431 - tRNA-Met tRNA gene992 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00993 VSVS12_00994 VSVS12_00994 VSVS12_00994 1048470 1048554 - tRNA-Leu tRNA gene993 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00994 VSVS12_00995 VSVS12_00995 VSVS12_00995 1048635 1048709 - tRNA-Gln tRNA gene994 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00995 VSVS12_00996 VSVS12_00996 VSVS12_00996 1048742 1048826 - tRNA-Leu tRNA gene995 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00996 VSVS12_00997 VSVS12_00997 VSVS12_00997 1048854 1048938 - tRNA-Leu tRNA gene996 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00997 VSVS12_00998 VSVS12_00998 VSVS12_00998 1048991 1049067 - tRNA-Met tRNA gene997 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00998 VSVS12_00999 VSVS12_00999 VSVS12_00999 1049147 1049221 - tRNA-Gln tRNA gene998 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_00999 VSVS12_01000 VSVS12_01000 VSVS12_01000 1049255 1049339 - tRNA-Leu tRNA gene999 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01000 VSVS12_01001 VSVS12_01001 VSVS12_01001 1049386 1049462 - tRNA-Met tRNA gene1000 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01001 VSVS12_01002 VSVS12_01002 VSVS12_01002 1049745 1050836 - Ribosome-binding ATPase YchF ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner%3B Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily%3B Contains 1 OBG-type G (guanine nucleotide-binding) domain gene gene1001 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01002 VSVS12_01003 VSVS12_01003 pth1 pth1 1050847 1051437 - Aminoacyl-tRNA hydrolase The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis%3B Belongs to the PTH family%3B KEGG: vvu:VV1_0258 peptidyl-tRNA hydrolase%2C PTH1 family gene gene1002 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01003 VSVS12_01004 VSVS12_01004 prpS prpS 1051634 1052578 - Ribose-phosphate diphosphokinase Involved in the biosynthesis of ribose 1%2C5-bisphosphate. Catalyzes the transfer of pyrophosphoryl group from ATP to ribose- 5-phosphate to yield phosphoribosyl diphosphate (PRPP) and AMP%3B Belongs to the ribose-phosphate pyrophosphokinase family%3B KEGG: eco:b1207 ribose-phosphate pyrophosphokinase gene gene1003 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01004 VSVS12_01005 VSVS12_01005 ispE ispE 1052608 1053480 - 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol%3B Belongs to the GHMP kinase family. IspE subfamily%3B KEGG: vcy:IX92_11100 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase gene gene1004 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01005 VSVS12_01006 VSVS12_01006 VSVS12_01006 1053480 1054097 - Outer-membrane lipoprotein LolB Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein%3B Belongs to the LolB family gene gene1005 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01006 VSVS12_01007 VSVS12_01007 hemA hemA 1054385 1055644 + Glutamyl-tRNA reductase Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)%3B Belongs to the glutamyl-tRNA reductase family%3B KEGG: eco:b1210 glutamyl-tRNA reductase gene gene1006 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01007 VSVS12_01008 VSVS12_01008 VSVS12_01008 1055668 1056756 + Peptide chain release factor Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA%3B Belongs to the prokaryotic/mitochondrial release factor family gene gene1007 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01008 VSVS12_01009 VSVS12_01009 hemK hemK 1056761 1057615 + Peptide chain release factor N(5)-glutamine methyltransferase Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif%3B Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily%3B KEGG: vni:VIBNI_A2679 release factor glutamine methyltransferase gene gene1008 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01009 VSVS12_01010 VSVS12_01010 VSVS12_01010 1057632 1058003 + hypothetical protein gene gene1009 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01010 VSVS12_01011 VSVS12_01011 VSVS12_01011 1058016 1058825 + UPF0162 protein Belongs to the UPF0162 family gene gene1010 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01011 VSVS12_01012 VSVS12_01012 kdsA kdsA 1058873 1059724 + 3-deoxy-8-phosphooctulonate synthase Belongs to the KdsA family%3B KEGG: eca:ECA2194 2-dehydro-3-deoxyphosphooctonate aldolase (KDO 8-P synthase) gene gene1011 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01012 VSVS12_01013 VSVS12_01013 ushA ushA 1060123 1061784 + 5'-nucleotidase Degradation of extracellular 5'-nucleotides for nutritional needs. Belongs to the 5'-nucleotidase family%3B KEGG: vvu:VV1_0248 5'-nucleotidase / UDP-sugar diphosphatase gene gene1012 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01013 VSVS12_01014 VSVS12_01014 ybaK ybaK 1062014 1062487 + Cys-tRNA(Pro)/Cys-tRNA(Cys) deacylase YbaK Functions in trans to edit the amino acid from incorrectly charged Cys-tRNA(Pro) via a Cys-tRNA(Pro) deacylase activity. May compensate for the lack of Cys-tRNA(Pro) editing by ProRS. Is also able to deacylate Cys-tRNA(Cys)%2C and displays weak deacylase activity in vitro against Gly-tRNA(Gly)%2C as well as%2C at higher concentrations%2C some other correctly charged tRNAs. Unlike some of its orthologs it is not able to remove the amino acid moiety from incorrectly charged Ala-tRNA(Pro)%3B Belongs to the prolyl-tRNA editing family. YbaK/EbsC subfamily%3B KEGG: maq:Maqu_0092 Cys-tRNA(Pro)/Cys-tRNA(Cys) deacylase%3B Carboxylic ester hydrolases gene gene1013 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01014 VSVS12_01015 VSVS12_01015 VSVS12_01015 1062576 1063769 - Transposase for insertion sequence element IS1001 Involved in the transposition of the insertion sequence. Belongs to the transposase 12 family gene gene1014 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01015 VSVS12_01016 VSVS12_01016 VSVS12_01016 1063960 1065198 - putative uracil permease Transport of uracil in the cell%3B Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2. A. 40) subfamily gene gene1015 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01016 VSVS12_01017 VSVS12_01017 VSVS12_01017 1065537 1066802 + hypothetical protein gene gene1016 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01017 VSVS12_01018 VSVS12_01018 VSVS12_01018 1066843 1067301 - hypothetical protein gene gene1017 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01018 VSVS12_01019 VSVS12_01019 wrbA wrbA 1067304 1067873 - NAD(P)H dehydrogenase (quinone) It seems to function in response to environmental stress when various electron transfer chains are affected or when the environment is highly oxidizing. It reduces quinones to the hydroquinone state to prevent interaction of the semiquinone with O2 and production of superoxide (By similarity)%3B Belongs to the WrbA family%3B Contains 1 flavodoxin-like domain%3B KEGG: vfu:vfu_A01153 NAD(P)H dehydrogenase (quinone) gene gene1018 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01019 VSVS12_01020 VSVS12_01020 arsC arsC 1067870 1068214 - Arsenate reductase (glutaredoxin) Reduction of arsenate [As(V)] to arsenite [As(III)]%3B Belongs to the ArsC family%3B KEGG: hin:HI0236 arsenate reductase gene gene1019 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01020 VSVS12_01021 VSVS12_01021 VSVS12_01021 1068228 1069685 - Putative beta-barrel assembly-enhancing protease Functions as both a chaperone and a metalloprotease. Maintains the integrity of the outer membrane by promoting either the assembly or the elimination of outer membrane proteins%2C depending on their folding state%3B Belongs to the peptidase M48 family. BepA subfamily%3B Contains 4 TPR repeats gene gene1020 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01021 VSVS12_01022 VSVS12_01022 VSVS12_01022 1069935 1070156 + hypothetical protein gene gene1021 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01022 VSVS12_01023 VSVS12_01023 VSVS12_01023 1070158 1071222 + Putative permease Belongs to the UPF0118 (PerM) family gene gene1022 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01023 VSVS12_01024 VSVS12_01024 VSVS12_01024 1071417 1073288 + Methyl-accepting chemotaxis protein PctA Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment%2C transduce a signal from the outside to the inside of the cell%2C and facilitate sensory adaptation through the variation of the level of methylation. Major receptor that responds to all naturally occurring L-amino acids%2C except L-Gln and L-Asp. Also involved in repellent responses to trichloroethylene (TCE)%2C chloroform and methylthiocyanate%3B Contains 1 cache domain%3B Contains 1 HAMP domain%3B Contains 1 methyl-accepting transducer domain gene gene1023 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01024 VSVS12_01025 VSVS12_01025 prxQ prxQ 1073370 1073507 - Peroxiredoxin Belongs to the AhpC/TSA family%3B Contains 1 thioredoxin domain%3B KEGG: hpr:PARA_09000 peroxiredoxin Q/BCP gene gene1024 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01025 VSVS12_01026 VSVS12_01026 VSVS12_01026 1073910 1074083 - hypothetical protein gene gene1025 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01026 VSVS12_01027 VSVS12_01027 VSVS12_01027 1074094 1074870 - hypothetical protein gene gene1026 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01027 VSVS12_01028 VSVS12_01028 hsdR hsdR 1074873 1078160 - Type I site-specific deoxyribonuclease To M. jannaschii MJ1214%3B KEGG: vha:VIBHAR_06807 type I restriction enzyme%2C R subunit gene gene1027 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01028 VSVS12_01029 VSVS12_01029 VSVS12_01029 1078203 1079039 - hypothetical protein gene gene1028 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01029 VSVS12_01030 VSVS12_01030 hsdS hsdS 1079105 1080346 - Type I site-specific deoxyribonuclease The M and S subunits together form a methyltransferase (MTase) that methylates two adenine residues in complementary strands of a bipartite DNA recognition sequence. In the presence of the R subunit the complex can also act as an endonuclease%2C binding to the same target sequence but cutting the DNA some distance from this site. Whether the DNA is cut or modified depends on the methylation state of the target sequence. When the target site is unmodified%2C the DNA is cut. When the target site is hemimethylated%2C the complex acts as a maintenance MTase modifying the DNA so that both strands become methylated. Subunit S dictates DNA sequences specificity (By similarity)%3B Belongs to the type-I restriction system S methylase family%3B KEGG: hie:R2846_0422 type I restriction enzyme%2C S subunit gene gene1029 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01030 VSVS12_01031 VSVS12_01031 hsdM hsdM 1080336 1081853 - Site-specific DNA-methyltransferase (adenine-specific) Methylation of specific adenine residue%3B required for both restriction and modification activities%3B Belongs to the N(4)/N(6)-methyltransferase family%3B KEGG: mvi:X808_10560 type I restriction enzyme M protein gene gene1030 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01031 VSVS12_01032 VSVS12_01032 VSVS12_01032 1081873 1082814 - hypothetical protein gene gene1031 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01032 VSVS12_01033 VSVS12_01033 VSVS12_01033 1082816 1083220 - hypothetical protein gene gene1032 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01033 VSVS12_01034 VSVS12_01034 VSVS12_01034 1083409 1084002 - hypothetical protein gene gene1033 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01034 VSVS12_01035 VSVS12_01035 VSVS12_01035 1084318 1085826 + Putative transposase Contains 1 integrase catalytic domain gene gene1034 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01035 VSVS12_01036 VSVS12_01036 VSVS12_01036 1085953 1086609 - hypothetical protein gene gene1035 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01036 VSVS12_01037 VSVS12_01037 VSVS12_01037 1086649 1087113 - Peroxiredoxin Belongs to the AhpC/TSA family%3B Contains 1 thioredoxin domain%3B KEGG: ipa:Isop_0033 peroxiredoxin Q/BCP gene gene1036 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01037 VSVS12_01038 VSVS12_01038 VSVS12_01038 1087274 1087777 - hypothetical protein gene gene1037 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01038 VSVS12_01039 VSVS12_01039 VSVS12_01039 1087777 1089972 - hypothetical protein gene gene1038 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01039 VSVS12_01040 VSVS12_01040 VSVS12_01040 1089987 1092314 - hypothetical protein gene gene1039 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01040 VSVS12_01041 VSVS12_01041 VSVS12_01041 1092314 1093717 - hypothetical protein gene gene1040 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01041 VSVS12_01042 VSVS12_01042 VSVS12_01042 1093788 1094141 - Peroxiredoxin Reduces hydrogen peroxide with reducing equivalents provided through the thioredoxin system. Could be involved in the photosystem II protection against hydrogen peroxide%3B Belongs to the AhpC/TSA family. PrxQ subfamily%3B Contains 1 thioredoxin domain%3B KEGG: vch:VC2160 peroxiredoxin Q/BCP gene gene1041 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01042 VSVS12_01043 VSVS12_01043 VSVS12_01043 1094154 1094696 - Glycine cleavage system transcriptional repressor Negative transcriptional regulator of the glycine cleavage system operon (GCV). Does not autoregulate its own expression. It is not yet known how GcvR acts as a repressor. It does not seem to bind DNA. It could interact with GcvA and suppress its activatory activity. Contains 2 ACT domains gene gene1042 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01043 VSVS12_01044 VSVS12_01044 dapA dapA 1095032 1095910 + 4-hydroxy-tetrahydrodipicolinate synthase Catalyzes the condensation of (S)-aspartate-beta- semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)%3B Belongs to the DapA family%3B KEGG: eco:b2478 4-hydroxy-tetrahydrodipicolinate synthase gene gene1043 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01044 VSVS12_01045 VSVS12_01045 VSVS12_01045 1095964 1096986 + Outer membrane protein assembly factor BamC Part of the outer membrane protein assembly complex%2C which is involved in assembly and insertion of beta-barrel proteins into the outer membrane%3B Belongs to the BamC family gene gene1044 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01045 VSVS12_01046 VSVS12_01046 VSVS12_01046 1097104 1098429 - putative membrane protein gene gene1045 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01046 VSVS12_01047 VSVS12_01047 VSVS12_01047 1098529 1099254 - Ribonuclease Trims short 3' overhangs of a variety of RNA species%2C leaving a one or two nucleotide 3' overhang. Responsible for the end-turnover of tRNA: specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis%3B Belongs to the RNase T family%3B Contains 1 exonuclease domain%3B KEGG: vch:VC1006 ribonuclease T%3B Exoribonucleases producing 5'-phosphomonoesters gene gene1046 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01047 VSVS12_01048 VSVS12_01048 VSVS12_01048 1099409 1100362 + Sodium-type flagellar protein MotY Plays the role of a stator in the sodium flagellar motor%2C stabilizing the force-generating unit through direct interaction with the cell wall. Involved in adherence and invasion of fish cell line. Belongs to the OmpA family%3B Contains 1 OmpA-like domain gene gene1047 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01048 VSVS12_01049 VSVS12_01049 VSVS12_01049 1100471 1100908 - uncharacterized protein gene gene1048 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01049 VSVS12_01050 VSVS12_01050 glo1 glo1 1101046 1101462 - Lactoylglutathione lyase Catalyzes the conversion of hemimercaptal%2C formed from methylglyoxal and glutathione%2C to S-lactoylglutathione%3B Belongs to the glyoxalase I family%3B KEGG: vvu:VV1_3100 lactoylglutathione lyase gene gene1049 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01050 VSVS12_01051 VSVS12_01051 VSVS12_01051 1101581 1102216 - DNA-(apurinic or apyrimidinic site) lyase DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond%2C leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination%2C leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate%3B Belongs to the Nth/MutY family%3B Contains 1 HhH domain%3B KEGG: efe:EFER_1410 endonuclease III gene gene1050 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01051 VSVS12_01052 VSVS12_01052 VSVS12_01052 1102355 1103044 - Electron transport complex subunit Part of a membrane complex involved in electron transport%3B Belongs to the NqrDE/RnfAE family%3B overlaps another CDS with the same product name gene gene1051 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01052 VSVS12_01053 VSVS12_01053 VSVS12_01053 1103037 1103675 - Electron transport complex subunit Part of a membrane complex involved in electron transport%3B Belongs to the RnfG family%3B overlaps another CDS with the same product name gene gene1052 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01053 VSVS12_01054 VSVS12_01054 VSVS12_01054 1103685 1104731 - Electron transport complex subunit Part of a membrane complex involved in electron transport%3B Belongs to the NqrB/RnfD family%3B overlaps another CDS with the same product name gene gene1053 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01054 VSVS12_01055 VSVS12_01055 VSVS12_01055 1104731 1107406 - Electron transport complex subunit Part of a membrane complex involved in electron transport%3B Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfC subfamily%3B Contains 2 4Fe-4S ferredoxin-type domains%3B overlaps another CDS with the same product name gene gene1054 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01055 VSVS12_01056 VSVS12_01056 VSVS12_01056 1107415 1108002 - Electron transport complex subunit B Part of a membrane complex involved in electron transport%3B Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfB subfamily%3B Contains 1 4Fe-4S domain%3B Contains 2 4Fe-4S ferredoxin-type domains gene gene1055 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01056 VSVS12_01057 VSVS12_01057 VSVS12_01057 1108002 1108583 - Electron transport complex subunit Part of a membrane complex involved in electron transport%3B Belongs to the NqrDE/RnfAE family gene gene1056 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01057 VSVS12_01058 VSVS12_01058 VSVS12_01058 1108944 1110257 + Anaerobic C4-dicarboxylate transporter DcuB Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane%3B Belongs to the DcuA/DcuB transporter (TC 2. A. 13. 1) family gene gene1057 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01058 VSVS12_01059 VSVS12_01059 VSVS12_01059 1110437 1110512 - tRNA-Asn tRNA gene1058 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01059 VSVS12_01060 VSVS12_01060 VSVS12_01060 1111055 1113085 + UvrABC system protein The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site%2C the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix%2C facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found%2C the DNA wraps around the other UvrB subunit that will check the other stand for damage%3B Belongs to the UvrB family%3B Contains 1 helicase ATP-binding domain%3B Contains 1 helicase C-terminal domain%3B Contains 1 UVR domain gene gene1059 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01060 VSVS12_01061 VSVS12_01061 VSVS12_01061 1113393 1114739 + Luminescence regulatory protein LuxO Acts negatively to control the expression of luminescence. At low cell density%2C LuxO is phosphorylated%2C and together with sigma-54%2C causes repression of the luxCDABEGH operon. This repression could be indirect%2C LuxO could activate a negative regulator of luminescence. At high cell density%2C LuxO is dephosphorylated and inactive%2C therefore the luxCDABEGH operon is not repressed and light is emitted. LuxO and sigma-54 have also a role in activating the production of siderophore and in regulating the rugose colony morphology phenotype%3B Contains 1 response regulatory domain%3B Contains 1 sigma-54 factor interaction domain gene gene1060 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01061 VSVS12_01062 VSVS12_01062 VSVS12_01062 1114742 1115098 + Phosphorelay protein LuxU Phosphorelay protein which receives sensory signals from LuxN and LuxP and transmits them to LuxO%2C at low cell density. LuxN and LuxP transfer a phosphoryl group to LuxU on His-58 and this phosphoryl group is further transferred to LuxO. At high cell density%2C as LuxU could function to establish an equilibrium between the aspartyl-phosphate of LuxN and the aspartyl-phosphate of LuxO%2C LuxU transfers phosphate from LuxO to LuxN (and probably LuxP) and finally phosphate is drained from the system. Contains 1 HPt domain gene gene1061 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01062 VSVS12_01063 VSVS12_01063 VSVS12_01063 1115084 1115971 - Putative gluconeoproteinis factor Required for morphogenesis under gluconeogenic growth conditions%3B Belongs to the gluconeogenesis factor family gene gene1062 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01063 VSVS12_01064 VSVS12_01064 moaA moaA 1116290 1117279 + Cyclic pyranopterin phosphate synthase Catalyzes%2C together with MoaC%2C the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z)%3B Belongs to the radical SAM superfamily. MoaA family%3B KEGG: vvu:VV1_3088 cyclic pyranopterin phosphate synthase gene gene1063 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01064 VSVS12_01065 VSVS12_01065 VSVS12_01065 1117370 1117882 + Molybdenum cofactor biosynthesis protein May be involved in the biosynthesis of molybdopterin. Can bind GTP and has low GTPase activity. Can bind MPT%2C but has no MPT adenylyl transferase activity%3B Belongs to the MoaB/Mog family gene gene1064 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01065 VSVS12_01066 VSVS12_01066 moaC moaC 1117907 1118386 + Cyclic pyranopterin phosphate synthase Together with MoaA%2C is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z)%3B Belongs to the MoaC family%3B KEGG: hdu:HD1391 cyclic pyranopterin phosphate synthase gene gene1065 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01066 VSVS12_01067 VSVS12_01067 VSVS12_01067 1118383 1118628 + Molybdopterin synthase sulfur carrier subunit Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin%3B Belongs to the MoaD family gene gene1066 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01067 VSVS12_01068 VSVS12_01068 moaE moaE 1118591 1119085 + Molybdopterin synthase Catalytic subunit of the molybdopterin synthase complex%2C a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group%3B Belongs to the MoaE family. MOCS2B subfamily%3B KEGG: vag:N646_1167 molybdopterin synthase catalytic subunit gene gene1067 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01068 VSVS12_01069 VSVS12_01069 VSVS12_01069 1119293 1119709 + IMP dehydrogenase KEGG: afu:AF_1259 IMP dehydrogenase gene gene1068 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01069 VSVS12_01070 VSVS12_01070 VSVS12_01070 1119775 1121235 + putative multidrug resistance protein YoeA Belongs to the multi antimicrobial extrusion (MATE) (TC 2. A. 66. 1) family gene gene1069 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01070 VSVS12_01071 VSVS12_01071 zntA zntA 1121298 1123604 + Cadmium-exporting ATPase Involved in export of lead%2C cadmium%2C zinc and mercury. Belongs to the cation transport ATPase (P-type) (TC 3. A. 3) family. Type IB subfamily%3B Contains 1 HMA domain%3B KEGG: vcy:IX92_10535 Cd2+/Zn2+-exporting ATPase gene gene1070 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01071 VSVS12_01072 VSVS12_01072 VSVS12_01072 1123904 1124662 + Uridine phosphorylase Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity)%3B Belongs to the PNP/UDP phosphorylase family%3B KEGG: vvu:VV1_2064 uridine phosphorylase gene gene1071 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01072 VSVS12_01073 VSVS12_01073 marS marS 1124853 1126910 - Methionine--tRNA ligase Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation%3B Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily%3B Contains 1 tRNA-binding domain%3B KEGG: vch:VC1036 methionyl-tRNA synthetase gene gene1072 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01073 VSVS12_01074 VSVS12_01074 VSVS12_01074 1127069 1128142 + Iron-sulfur cluster carrier protein Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP%3B Belongs to the Mrp/NBP35 ATP-binding proteins family gene gene1073 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01074 VSVS12_01075 VSVS12_01075 VSVS12_01075 1128387 1129028 + Uridine kinase Belongs to the uridine kinase family%3B KEGG: vch:VC1038 uridine kinase gene gene1074 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01075 VSVS12_01076 VSVS12_01076 VSVS12_01076 1129200 1131329 + Protein AsmA gene gene1075 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01076 VSVS12_01077 VSVS12_01077 VSVS12_01077 1131440 1132045 - Cob(I)yrinic acid a%2Cc-diamide adenosyltransferase Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids (By similarity)%3B Belongs to the Cob(I)alamin adenosyltransferase family%3B KEGG: vpa:VP2065 cob(I)alamin adenosyltransferase gene gene1076 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01077 VSVS12_01078 VSVS12_01078 VSVS12_01078 1132176 1132625 + Protein-tyrosine-phosphatase KEGG: vch:VC1041 protein-tyrosine phosphatase gene gene1077 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01078 VSVS12_01079 VSVS12_01079 VSVS12_01079 1132648 1133310 - hypothetical protein gene gene1078 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01079 VSVS12_01080 VSVS12_01080 VSVS12_01080 1133497 1134000 - hypothetical protein gene gene1079 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01080 VSVS12_01081 VSVS12_01081 sod2 sod2 1134124 1134708 - Superoxide dismutase Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems%3B Belongs to the iron/manganese superoxide dismutase family%3B KEGG: eco:b1656 superoxide dismutase%2C Fe-Mn family gene gene1080 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01081 VSVS12_01082 VSVS12_01082 VSVS12_01082 1135096 1135431 + Glutaredoxin-4 Monothiol glutaredoxin involved in the biogenesis of iron-sulfur clusters%3B Belongs to the glutaredoxin family. Monothiol subfamily%3B Contains 1 glutaredoxin domain gene gene1081 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01082 VSVS12_01083 VSVS12_01083 topB topB 1135531 1137474 + DNA topoisomerase Releases the supercoiling and torsional tension of DNA%2C which is introduced during the DNA replication and transcription%2C by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme%2C resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand%2C thus removing DNA supercoils. Finally%2C in the religation step%2C the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone%3B Belongs to the type IA topoisomerase family%3B Contains 1 Toprim domain%3B KEGG: spq:SPAB_02045 DNA topoisomerase III gene gene1082 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01083 VSVS12_01084 VSVS12_01084 VSVS12_01084 1137527 1137730 - hypothetical protein gene gene1083 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01084 VSVS12_01085 VSVS12_01085 VSVS12_01085 1138125 1139042 + Histone deacetylase Putative deacetylase%3B Belongs to the histone deacetylase family%3B KEGG: tcc:TCM_037278 histone deacetylase 11 gene gene1084 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01085 VSVS12_01086 VSVS12_01086 VSVS12_01086 1139075 1140697 - uncharacterized protein Contains 1 EAL domain%3B Contains 1 GGDEF domain gene gene1085 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01086 VSVS12_01087 VSVS12_01087 VSVS12_01087 1140906 1142342 - uncharacterized protein gene gene1086 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01087 VSVS12_01088 VSVS12_01088 VSVS12_01088 1142346 1143497 - Cystathionine gamma-synthase Catalyzes the formation of L-cystathionine from O- succinyl-L-homoserine (OSHS) and L-cysteine%2C via a gamma- replacement reaction. In the absence of thiol%2C catalyzes gamma- elimination to form 2-oxobutanoate%2C succinate and ammonia (By similarity)%3B Belongs to the trans-sulfuration enzymes family%3B KEGG: pmr:PMI3223 cystathionine gamma-synthase gene gene1087 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01088 VSVS12_01089 VSVS12_01089 VSVS12_01089 1143712 1144620 - hypothetical protein gene gene1088 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01089 VSVS12_01090 VSVS12_01090 VSVS12_01090 1144755 1145483 - Mannosyl-D-glycerate transport/metabolism system repressor MngR Represses mngA and mngB. Regulates its own expression%3B Contains 1 HTH gntR-type DNA-binding domain gene gene1089 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01090 VSVS12_01091 VSVS12_01091 tktA tktA 1145646 1146587 - Transketolase Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)%3B Belongs to the transketolase family. DXPS subfamily%3B KEGG: axy:AXYL_04857 transketolase%3B overlaps another CDS with the same product name gene gene1090 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01091 VSVS12_01092 VSVS12_01092 VSVS12_01092 1146584 1147435 - Transketolase Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor%2C via a covalent intermediate with the cofactor thiamine pyrophosphate%3B Belongs to the transketolase family%3B KEGG: mvn:Mevan_0440 transketolase%3B overlaps another CDS with the same product name gene gene1091 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01092 VSVS12_01093 VSVS12_01093 VSVS12_01093 1147489 1148841 - Ascorbate-specific permease IIC component UlaA The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS)%2C a major carbohydrate active- transport system%2C catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. This system is involved in ascorbate transport (By similarity)%3B Belongs to the UlaA family gene gene1092 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01093 VSVS12_01094 VSVS12_01094 ulaB ulaB 1148853 1149119 - Protein-N(pi)-phosphohistidine--sugar phosphotransferase KEGG: efe:EFER_0867 PTS system%2C ascorbate-specific IIB component gene gene1093 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01094 VSVS12_01095 VSVS12_01095 ulaC ulaC 1149130 1149573 - Protein-N(pi)-phosphohistidine--sugar phosphotransferase The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS)%2C a major carbohydrate active -transport system%2C catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane%3B Contains 1 PTS EIIA type-2 domain%3B KEGG: plu:plu1979 PTS system%2C ascorbate-specific IIA component gene gene1094 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01095 VSVS12_01096 VSVS12_01096 aphA aphA 1150153 1150860 - Acid phosphatase Dephosphorylates several organic phosphate monoesters. Also has a phosphotransferase activity catalyzing the transfer of low-energy phosphate groups from organic phosphate monoesters to free hydroxyl groups of various organic compounds (By similarity)%3B Belongs to the class B bacterial acid phosphatase family%3B KEGG: eic:NT01EI_3833 acid phosphatase (class B) gene gene1095 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01096 VSVS12_01097 VSVS12_01097 VSVS12_01097 1151129 1152451 - Coenzyme A disulfide reductase Belongs to the class-III pyridine nucleotide-disulfide oxidoreductase family%3B KEGG: gca:Galf_0318 tRNA 2-thiouridine synthesizing protein A%3B Sulfurtransferases gene gene1096 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01097 VSVS12_01098 VSVS12_01098 VSVS12_01098 1152528 1153940 - L-cystine uptake protein TcyP Mediates uptake of L-cystine%2C the oxidized form of L- cysteine%3B Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2. A. 23) family gene gene1097 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01098 VSVS12_01099 VSVS12_01099 VSVS12_01099 1153980 1154363 - 2-iminobutanoate/2-iminopropanoate deaminase Belongs to the RutC family%3B KEGG: ror:RORB6_16900 2-iminobutanoate/2-iminopropanoate deaminase gene gene1098 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01099 VSVS12_01100 VSVS12_01100 VSVS12_01100 1154391 1155056 - uncharacterized protein To E. coli YheO gene gene1099 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01100 VSVS12_01101 VSVS12_01101 VSVS12_01101 1155517 1156923 - uncharacterized protein To E. coli YfcC%3B To B. subtilis YcgA gene gene1100 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01101 VSVS12_01102 VSVS12_01102 VSVS12_01102 1156972 1158081 - Opine dehydrogenase In the forward direction acts also on secondary amine dicarboxylates such as N-(1-carboxyethyl)methionine and N-(1- carboxyethyl)phenylalanine. In the reverse direction%2C the enzyme also acts on neutral amino acids as an amino donor. They include L-amino acids such as 2-aminopentanoic acid%2C 2-aminobutyric acid%2C 2-aminohexanoic acid%2C 3-chloroalanine%2C O-acetylserine%2C methionine%2C isoleucine%2C valine%2C phenylalanine%2C leucine and alanine. Belongs to the lysopine/nopaline/octopine/opine/vitopine dehydrogenases family%3B KEGG: psy:PCNPT3_02670 opine dehydrogenase gene gene1101 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01102 VSVS12_01103 VSVS12_01103 VSVS12_01103 1158336 1159259 - Regulatory protein NocR Positive regulatory protein for the noc operon involved in nopaline catabolism and uptake. Contains 1 HTH lysR-type DNA-binding domain gene gene1102 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01103 VSVS12_01104 VSVS12_01104 VSVS12_01104 1159546 1159636 - tRNA-Ser tRNA gene1103 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01104 VSVS12_01105 VSVS12_01105 VSVS12_01105 1159966 1160042 - tRNA-Pro tRNA gene1104 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01105 VSVS12_01106 VSVS12_01106 VSVS12_01106 1160094 1161893 - uncharacterized protein To E. coli YejM gene gene1105 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01106 VSVS12_01107 VSVS12_01107 VSVS12_01107 1161919 1162143 - UPF0352 protein Belongs to the UPF0352 family gene gene1106 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01107 VSVS12_01108 VSVS12_01108 VSVS12_01108 1162176 1163228 + Nucleoid-associated protein Belongs to the YejK family gene gene1107 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01108 VSVS12_01109 VSVS12_01109 VSVS12_01109 1163428 1164771 + hypothetical protein gene gene1108 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01109 VSVS12_01110 VSVS12_01110 VSVS12_01110 1164976 1166130 + hypothetical protein gene gene1109 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01110 VSVS12_01111 VSVS12_01111 VSVS12_01111 1166206 1167642 - Malate-2H(+)/Na(+)-lactate antiporter Couples proton uptake and Na(+) efflux to the substrate- product malate/lactate antiport%2C in an electroneutral malate- 2H(+)/Na(+)-lactate exchange. Plays a role in supporting growth to high density on malate at reduced protonmotive force. Belongs to the NhaC Na(+)/H(+) (TC 2. A. 35) antiporter family gene gene1110 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01111 VSVS12_01112 VSVS12_01112 VSVS12_01112 1168200 1169318 + Aspartate-semialdehyde dehydrogenase Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate%3B Belongs to the aspartate-semialdehyde dehydrogenase family%3B KEGG: bfl:Bfl574 aspartate-semialdehyde dehydrogenase gene gene1111 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01112 VSVS12_01113 VSVS12_01113 VSVS12_01113 1169646 1170074 + Nta operon transcriptional regulator Probable regulator for the expression of the NTA monooxygenase subunits. Contains 1 HTH gntR-type DNA-binding domain gene gene1112 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01113 VSVS12_01114 VSVS12_01114 VSVS12_01114 1170089 1170301 + hypothetical protein gene gene1113 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01114 VSVS12_01115 VSVS12_01115 VSVS12_01115 1170471 1170992 + hypothetical protein gene gene1114 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01115 VSVS12_01116 VSVS12_01116 VSVS12_01116 1171106 1171957 - Potassium voltage-gated channel subfamily G member Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB%3B modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 (PubMed:19074135)%3B Belongs to the potassium channel family. G (TC 1. A. 1. 2) subfamily. Kv6. 1/KCNG1 sub-subfamily gene gene1115 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01116 VSVS12_01117 VSVS12_01117 VSVS12_01117 1172035 1172676 - UPF0056 membrane protein Belongs to the UPF0056 (MarC) family gene gene1116 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01117 VSVS12_01118 VSVS12_01118 adhE adhE 1173327 1176023 + Acetaldehyde dehydrogenase (acetylating) This enzyme has three activities: ADH%2C ACDH%2C and PFL- deactivase. In aerobic conditions it acts as a hydrogen peroxide scavenger. The PFL deactivase activity catalyzes the quenching of the pyruvate-formate-lyase catalyst in an iron%2C NAD%2C and CoA dependent reaction (By similarity)%3B In the N-terminal sectio%3B belongs to the aldehyde dehydrogenase family%3B In the C-terminal sectio%3B belongs to the iron- containing alcohol dehydrogenase family%3B KEGG: eco:b1241 acetaldehyde dehydrogenase / alcohol dehydrogenase gene gene1117 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01118 VSVS12_01119 VSVS12_01119 VSVS12_01119 1176956 1177219 - Cell division topological specificity factor Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell%3B Belongs to the MinE family gene gene1118 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01119 VSVS12_01120 VSVS12_01120 VSVS12_01120 1177226 1178038 - Septum site-determining protein MinD ATPase required for the correct placement of the division site. Cell division inhibitors MinC and MinD act in concert to form an inhibitor capable of blocking formation of the polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings (By similarity)%3B Belongs to the ParA family. MinD subfamily gene gene1119 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01120 VSVS12_01121 VSVS12_01121 VSVS12_01121 1178059 1178721 - putative septum site-determining protein MinC Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization%3B Belongs to the MinC family gene gene1120 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01121 VSVS12_01122 VSVS12_01122 VSVS12_01122 1178904 1179185 + YcgL domain-containing protein Contains 1 YcgL domain gene gene1121 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01122 VSVS12_01123 VSVS12_01123 VSVS12_01123 1179212 1180186 + Membrane-bound lytic murein transglycosylase gene gene1122 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01123 VSVS12_01124 VSVS12_01124 VSVS12_01124 1180251 1181204 + HTH-type transcriptional regulator BudR Regulator of the budABC operon for 2%2C3-butanediol synthesis%3B Contains 1 HTH lysR-type DNA-binding domain gene gene1123 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01124 VSVS12_01125 VSVS12_01125 VSVS12_01125 1181421 1182620 + Putative nucleoside permease NupX Belongs to the concentrative nucleoside transporter (CNT) (TC 2. A. 41) family gene gene1124 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01125 VSVS12_01126 VSVS12_01126 folD folD 1183472 1184332 - Methylenetetrahydrofolate dehydrogenase (NADP(+)) Catalyzes the oxidation of 5%2C10- methylenetetrahydrofolate to 5%2C10-methenyltetrahydrofolate and then the hydrolysis of 5%2C10-methenyltetrahydrofolate to 10- formyltetrahydrofolate%3B Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family%3B KEGG: vch:VC1942 methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase gene gene1125 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01126 VSVS12_01127 VSVS12_01127 VSVS12_01127 1184535 1184611 + tRNA-Arg tRNA gene1126 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01127 VSVS12_01128 VSVS12_01128 VSVS12_01128 1184785 1185330 - hypothetical protein gene gene1127 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01128 VSVS12_01129 VSVS12_01129 VSVS12_01129 1185348 1186412 - hypothetical protein gene gene1128 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01129 VSVS12_01130 VSVS12_01130 VSVS12_01130 1186422 1186691 - hypothetical protein gene gene1129 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01130 VSVS12_01131 VSVS12_01131 VSVS12_01131 1186688 1187353 - hypothetical protein gene gene1130 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01131 VSVS12_01132 VSVS12_01132 VSVS12_01132 1187424 1187846 - hypothetical protein gene gene1131 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01132 VSVS12_01133 VSVS12_01133 VSVS12_01133 1188507 1189466 + hypothetical protein gene gene1132 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01133 VSVS12_01134 VSVS12_01134 VSVS12_01134 1189992 1191260 - hypothetical protein gene gene1133 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01134 VSVS12_01135 VSVS12_01135 VSVS12_01135 1191647 1192342 - hypothetical protein gene gene1134 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01135 VSVS12_01136 VSVS12_01136 VSVS12_01136 1192925 1193632 - hypothetical protein gene gene1135 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01136 VSVS12_01137 VSVS12_01137 VSVS12_01137 1193632 1195227 - (6-4) photolyase Photolyase involved in the repair of UV-induced (6-4) lesions in DNA. Catalyzes the photoreactivation of (6-4) pyrimidine-pyrimidone photoproducts by using blue-light energy. Can repair (6-4) photoproducts in ssDNA as well as in dsDNA%3B Belongs to the iron-sulfur bacterial cryptochrome/photolyase (FeS-BCP) family gene gene1136 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01137 VSVS12_01138 VSVS12_01138 phrB phrB 1195227 1196567 - Deoxyribodipyrimidine photo-lyase May have a photoreceptor function. Binds DN%3B probably functions as a transcriptional repressor (By similarity). Has no photolyase activity. Upon purification from either V. cholerae or E. coli an approximately 60 nucleotide RNA is associated with the protein%3B Belongs to the DNA photolyase class-1 family%3B Contains 1 photolyase/cryptochrome alpha/beta domain%3B KEGG: vcx:VAA049_1056 deoxyribodipyrimidine photo-lyase gene gene1137 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01138 VSVS12_01139 VSVS12_01139 VSVS12_01139 1196742 1197137 + hypothetical protein gene gene1138 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01139 VSVS12_01140 VSVS12_01140 patB patB 1197277 1198473 - Cystathionine beta-lyase Acts as a beta-cystathionase and as a repressor of the maltose regulon. Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. MalY/PatB cystathionine beta-lyase subfamily%3B KEGG: enr:H650_03875 cystathione beta-lyase gene gene1139 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01140 VSVS12_01141 VSVS12_01141 celC celC 1198571 1198927 - Protein-N(pi)-phosphohistidine--sugar phosphotransferase The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS)%2C a major carbohydrate active -transport system%2C catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. This system is involved in N%2CN'-diacetylchitobiose transport (By similarity)%3B Contains 1 PTS EIIA type-3 domain%3B KEGG: pmr:PMI2954 PTS system%2C cellobiose-specific IIA component gene gene1140 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01141 VSVS12_01142 VSVS12_01142 VSVS12_01142 1199258 1200466 + hypothetical protein gene gene1141 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01142 VSVS12_01143 VSVS12_01143 celA celA 1200441 1200791 + Protein-N(pi)-phosphohistidine--sugar phosphotransferase KEGG: lcr:LCRIS_01428 PTS system%2C cellobiose-specific IIB component gene gene1142 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01143 VSVS12_01144 VSVS12_01144 VSVS12_01144 1200863 1202206 + Cellobiose permease IIC component The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS)%2C a major carbohydrate active -transport system%2C catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. This system is involved in cellobiose transport. Contains 1 PTS EIIC type-3 domain gene gene1143 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01144 VSVS12_01145 VSVS12_01145 VSVS12_01145 1202321 1203391 + Xaa-Pro aminopeptidase Splits dipeptides with a prolyl in the C-terminal position and a nonpolar amino acid at the N-terminal position%3B Belongs to the peptidase M24B family. Archaeal-type prolidase subfamily%3B KEGG: lfu:HR49_02820 Xaa-Pro aminopeptidase gene gene1144 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01145 VSVS12_01146 VSVS12_01146 VSVS12_01146 1203438 1204490 + Cellulase Belongs to the peptidase M42 family%3B KEGG: css:Cst_c05910 endoglucanase gene gene1145 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01146 VSVS12_01147 VSVS12_01147 VSVS12_01147 1204438 1206201 - hypothetical protein gene gene1146 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01147 VSVS12_01148 VSVS12_01148 VSVS12_01148 1207012 1208220 - hypothetical protein gene gene1147 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01148 VSVS12_01149 VSVS12_01149 VSVS12_01149 1208327 1209073 + Putative aga operon transcriptional repressor Probable repressor for the aga operon for N-acetyl galactosamine transport and metabolism%3B Contains 1 HTH deoR-type DNA-binding domain gene gene1148 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01149 VSVS12_01150 VSVS12_01150 agaV agaV 1209088 1209576 + Protein-N(pi)-phosphohistidine--sugar phosphotransferase The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS)%2C a major carbohydrate active -transport system%2C catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in fructose transport. LevD and LevE act as negative regulators of the levanase operon. They may be involved in a PTS-mediated phosphorylation of a regulator. Contains 1 PTS EIIB type-4 domain%3B KEGG: vvy:VV0537 PTS system%2C N-acetylgalactosamine-specific IIB component gene gene1149 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01150 VSVS12_01151 VSVS12_01151 VSVS12_01151 1209588 1210358 + Putative N-acetylgalactosamine permease IIC component The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS)%2C a major carbohydrate active -transport system%2C catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. This system is involved in N-acetylgalactosamine transport. Contains 1 PTS EIIC type-4 domain gene gene1150 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01151 VSVS12_01152 VSVS12_01152 VSVS12_01152 1210345 1211232 + Fructose permease IID component The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS)%2C a major carbohydrate active -transport system%2C catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. This system is involved in fructose transport. Contains 1 PTS EIID domain gene gene1151 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01152 VSVS12_01153 VSVS12_01153 agaF agaF 1211245 1211685 + Protein-N(pi)-phosphohistidine--sugar phosphotransferase The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS)%2C a major carbohydrate active -transport system%2C catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in fructose transport. LevD and LevE act as negative regulators of the levanase operon. They may be involved in a PTS-mediated phosphorylation of a regulator. Contains 1 PTS EIIA type-4 domain%3B KEGG: ses:SARI_01161 PTS system%2C N-acetylgalactosamine-specific IIA component gene gene1152 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01153 VSVS12_01154 VSVS12_01154 yteR yteR 1211861 1212901 + Unsaturated rhamnogalacturonyl hydrolase KEGG: hdl:HALDL1_04845 unsaturated rhamnogalacturonyl hydrolase gene gene1153 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01154 VSVS12_01155 VSVS12_01155 lacA lacA 1213046 1213687 + Galactose-6-phosphate isomerase KEGG: sgl:SG1887 galactose-6-phosphate isomerase gene gene1154 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01155 VSVS12_01156 VSVS12_01156 VSVS12_01156 1213790 1215277 + hypothetical protein gene gene1155 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01156 VSVS12_01157 VSVS12_01157 VSVS12_01157 1215353 1216135 - Pectin degradation repressor protein KdgR Transcriptional repressor of genes involved in pectinolysis and in pectinase secretion. Controls all the genes involved in pectin catabolism%2C including the pel genes encoding pectate lyases%2C KdgT which encodes the 2-keto-3-deoxygluconate transport system and KdgK which encodes the kdg kinase. Contains 1 HTH iclR-type DNA-binding domain%3B Contains 1 iclR-ED (iclR effector binding) domain gene gene1156 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01157 VSVS12_01158 VSVS12_01158 kduD kduD 1216416 1217177 + 2-deoxy-D-gluconate 3-dehydrogenase Catalyzes the reduction of 2%2C5-diketo-3-deoxygluconate (DKII or 4%2C6-dihydroxy-2%2C5-dioxohexanoate) into 2-keto-3- deoxygluconate (KDG or 2-dehydro-3-deoxygluconate) with a concomitant oxidation of NADH%3B Belongs to the short-chain dehydrogenases/reductases (SDR) family%3B KEGG: ype:YPO1724 2-deoxy-D-gluconate 3-dehydrogenase gene gene1157 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01158 VSVS12_01159 VSVS12_01159 VSVS12_01159 1217225 1217758 + Inner membrane protein YgjV gene gene1158 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01159 VSVS12_01160 VSVS12_01160 kdgK kdgK 1217868 1218797 + 2-dehydro-3-deoxygluconokinase Catalyzes the phosphorylation of 2-keto-3-deoxygluconate (KDG) to produce 2-keto-3-deoxy-6-phosphogluconate (KDPG)%3B Belongs to the carbohydrate kinase PfkB family%3B KEGG: vvy:VV0554 2-dehydro-3-deoxygluconokinase gene gene1159 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01160 VSVS12_01161 VSVS12_01161 VSVS12_01161 1218856 1219203 + 2-dehydro-3-deoxy-phosphogluconate aldolase Belongs to the KHG/KDPG aldolase family%3B KEGG: vag:N646_4456 2-dehydro-3-deoxyphosphogluconate aldolase / (4S)-4-hydroxy-2-oxoglutarate aldolase gene gene1160 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01161 VSVS12_01162 VSVS12_01162 VSVS12_01162 1219215 1219478 + 2-dehydro-3-deoxy-phosphogluconate aldolase Belongs to the KHG/KDPG aldolase family%3B KEGG: vch:VC0285 2-dehydro-3-deoxyphosphogluconate aldolase / (4S)-4-hydroxy-2-oxoglutarate aldolase gene gene1161 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01162 VSVS12_01163 VSVS12_01163 VSVS12_01163 1219529 1220881 - putative chaperone protein YegD Belongs to the heat shock protein 70 family gene gene1162 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01163 VSVS12_01164 VSVS12_01164 VSVS12_01164 1221219 1222079 + Disulfide-bond oxidoreductase YghU Exhibits a robust glutathione (GSH)-dependent disulfide- bond reductase activity toward the model substrate%2C 2-hydroxyethyl disulfid%3B the actual physiological substrates are not known. Also displays a modest GSH-dependent peroxidase activity toward several organic hydroperoxides%2C such as cumene hydroperoxide and linoleic acid 13(S)-hydroperoxide%2C but does not reduce H(2)O(2) or tert- butyl hydroperoxide at appreciable rates. Exhibits little or no GSH transferase activity with most typical electrophilic substrates%2C and has no detectable transferase activity toward 1- chloro-2%2C4-dinitrobenzene (CDNB) with glutathionylspermidine (GspSH) as the nucleophilic substrate%3B Belongs to the GST superfamily. Nu-class GSH transferase family%3B Contains 1 GST C-terminal domain%3B Contains 1 GST N-terminal domain gene gene1163 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01164 VSVS12_01165 VSVS12_01165 VSVS12_01165 1222139 1222900 - hypothetical protein gene gene1164 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01165 VSVS12_01166 VSVS12_01166 VSVS12_01166 1223260 1223703 + hypothetical protein gene gene1165 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01166 VSVS12_01167 VSVS12_01167 VSVS12_01167 1223752 1223844 - hypothetical protein gene gene1166 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01167 VSVS12_01168 VSVS12_01168 VSVS12_01168 1223882 1223983 + hypothetical protein gene gene1167 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01168 VSVS12_01169 VSVS12_01169 VSVS12_01169 1224106 1225575 + UPF0061 protein Belongs to the UPF0061 (SELO) family gene gene1168 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01169 VSVS12_01170 VSVS12_01170 VSVS12_01170 1225840 1226838 + C4-dicarboxylate-binding protein DctB Part of the binding-protein-dependent transport system for uptake of C4-dicarboxylates. Responsible for growth on fumarate and succinate but not malate. Is not directly involved in C4-dicarboxylate uptake%2C but plays a sensory role in the DctS/DctR two-component system which regulates the expression of the dctA C4-dicarboxylate transporter%3B Belongs to the bacterial solute-binding protein 7 family gene gene1169 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01170 VSVS12_01171 VSVS12_01171 VSVS12_01171 1226911 1227591 + Putative TRAP transporter small permease protein Belongs to the TRAP transporter small permease family gene gene1170 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01171 VSVS12_01172 VSVS12_01172 VSVS12_01172 1227592 1228953 + Sialic acid TRAP transporter permease protein SiaT Part of the tripartite ATP-independent periplasmic (TRAP) transport system SiaPT involved in the uptake of sialic acid%3B In the N-terminal sectio%3B belongs to the TRAP transporter small permease family%3B In the C-terminal sectio%3B belongs to the TRAP transporter large permease family gene gene1171 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01172 VSVS12_01173 VSVS12_01173 VSVS12_01173 1229040 1229228 - hypothetical protein gene gene1172 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01173 VSVS12_01174 VSVS12_01174 VSVS12_01174 1229351 1230184 - Iron-chelate-transporting ATPase Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system%3B Belongs to the ABC transporter superfamily. Heme (hemin) importer (TC 3. A. 1. 14. 5) family%3B Contains 1 ABC transporter domain%3B KEGG: cko:CKO_03217 iron complex transport system ATP-binding protein gene gene1173 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01174 VSVS12_01175 VSVS12_01175 VSVS12_01175 1230184 1231239 - Putative ABC transporter permease protein Probably part of a binding-protein-dependent transport system. Probably responsible for the translocation of the substrate across the membrane. Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily gene gene1174 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01175 VSVS12_01176 VSVS12_01176 VSVS12_01176 1231264 1232136 - Hemin-binding periplasmic protein HmuT Part of the binding-protein-dependent transport system for hemin. Contains 1 Fe/B12 periplasmic-binding domain gene gene1175 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01176 VSVS12_01177 VSVS12_01177 VSVS12_01177 1232136 1232570 - Biopolymer transport protein exbD1 Involved in the TonB-dependent energy-dependent transport of various receptor-bound substrates%3B Belongs to the ExbD/TolR family gene gene1176 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01177 VSVS12_01178 VSVS12_01178 VSVS12_01178 1232570 1233286 - Biopolymer transport protein exbB1 Involved in the TonB-dependent energy-dependent transport of various receptor-bound substrates. Protects ExbD from proteolytic degradation and functionally stabilizes TonB (By similarity)%3B Belongs to the ExbB/TolQ family gene gene1177 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01178 VSVS12_01179 VSVS12_01179 VSVS12_01179 1233298 1233621 - Protein TonB Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane%2C resulting in the release into the periplasm of ligands bound by these outer membrane proteins (By similarity)%3B Belongs to the TonB family gene gene1178 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01179 VSVS12_01180 VSVS12_01180 VSVS12_01180 1233623 1234204 - hypothetical protein gene gene1179 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01180 VSVS12_01181 VSVS12_01181 VSVS12_01181 1234449 1235858 + Coproporphyrinogen dehydrogenase Involved in the biosynthesis of porphyrin-containing compound%3B Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemN-like subfamily%3B KEGG: vch:VCA0909 oxygen-independent coproporphyrinogen III oxidase gene gene1180 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01181 VSVS12_01182 VSVS12_01182 VSVS12_01182 1235894 1236415 + hypothetical protein gene gene1181 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01182 VSVS12_01183 VSVS12_01183 VSVS12_01183 1236412 1236996 + hypothetical protein gene gene1182 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01183 VSVS12_01184 VSVS12_01184 VSVS12_01184 1237081 1238172 + Hemoglobin and hemoglobin-haptoglobin-binding protein B Acts as a receptor for hemoglobin or the hemoglobin/haptoglobin complex of the human host and is required for heme uptake. Belongs to the TonB-dependent receptor family. Hemoglobin/haptoglobin binding protein subfamily gene gene1183 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01184 VSVS12_01185 VSVS12_01185 VSVS12_01185 1238226 1239194 + Hemoglobin and hemoglobin-haptoglobin-binding protein Acts as a receptor for hemoglobin or the hemoglobin/haptoglobin complex of the host and is required for heme uptake. May be involved in virulence%3B Belongs to the TonB-dependent receptor family. Hemoglobin/haptoglobin binding protein subfamily gene gene1184 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01185 VSVS12_01186 VSVS12_01186 VSVS12_01186 1239250 1240587 - Acetoacetate metabolism regulatory protein Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis. Contains 1 response regulatory domain%3B Contains 1 sigma-54 factor interaction domain gene gene1185 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01186 VSVS12_01187 VSVS12_01187 dctB dctB 1240587 1242419 - Histidine kinase Member of the two-component regulatory system DctB/DctD involved in the transport of C4-dicarboxylates. DctB functions as a membrane-associated protein kinase that phosphorylates DctD in response to environmental signals. Contains 1 histidine kinase domain%3B KEGG: van:VAA_02300 two-component system%2C NtrC family%2C C4-dicarboxylate transport sensor histidine kinase DctB gene gene1186 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01187 VSVS12_01188 VSVS12_01188 VSVS12_01188 1242959 1244260 + Trigger factor Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase%3B Belongs to the FKBP-type PPIase family. Tig subfamily%3B Contains 1 PPIase FKBP-type domain gene gene1187 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01188 VSVS12_01189 VSVS12_01189 clpP clpP 1244367 1244981 + Endopeptidase Clp Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins%3B Belongs to the peptidase S14 family%3B KEGG: mec:Q7C_2671 ATP-dependent Clp protease%2C protease subunit gene gene1188 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01189 VSVS12_01190 VSVS12_01190 VSVS12_01190 1245105 1246385 + ATP-dependent Clp protease ATP-binding subunit ClpX ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP%3B Belongs to the ClpX chaperone family gene gene1189 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01190 VSVS12_01191 VSVS12_01191 VSVS12_01191 1246512 1248863 + Endopeptidase La ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Binds to DNA in a double-stranded%2C site-specific manner (By similarity). Regulates swarmer cell differentiation of V. parahaemolyticus%3B Belongs to the peptidase S16 family%3B Contains 1 Lon domain%3B KEGG: plu:plu3867 ATP-dependent Lon protease gene gene1190 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01191 VSVS12_01192 VSVS12_01192 VSVS12_01192 1249057 1249329 + DNA-binding protein HU-1 Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it%2C and thus to prevent its denaturation under extreme environmental conditions%3B Belongs to the bacterial histone-like protein family gene gene1191 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01192 VSVS12_01193 VSVS12_01193 ppiD ppiD 1249501 1251360 + Peptidylprolyl isomerase PPIases accelerate the folding of proteins%3B Contains 1 PpiC domain%3B KEGG: vch:VC1918 peptidyl-prolyl cis-trans isomerase D gene gene1192 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01193 VSVS12_01194 VSVS12_01194 VSVS12_01194 1251498 1251812 + uncharacterized protein Contains 2 HhH domains gene gene1193 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01194 VSVS12_01195 VSVS12_01195 VSVS12_01195 1252092 1252772 + UMP/CMP kinase Belongs to the cytidylate kinase family. Type 1 subfamily%3B KEGG: vch:VC1916 cytidylate kinase gene gene1194 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01195 VSVS12_01196 VSVS12_01196 VSVS12_01196 1252881 1254551 + 30S ribosomal protein S1 Binds mRN%3B thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)%3B Belongs to the ribosomal protein S1P family%3B Contains 6 S1 motif domains gene gene1195 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01196 VSVS12_01197 VSVS12_01197 VSVS12_01197 1254754 1255035 + Integration host factor subunit beta This protein is one of the two subunits of integration host factor%2C a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control%3B Belongs to the bacterial histone-like protein family gene gene1196 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01197 VSVS12_01198 VSVS12_01198 VSVS12_01198 1255169 1255447 + putative lipopolysaccharide assembly protein Involved in the assembly of lipopolysaccharide (LPS)%3B Belongs to the LapA family gene gene1197 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01198 VSVS12_01199 VSVS12_01199 VSVS12_01199 1255473 1256642 + Lipopolysaccharide assembly protein Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC%2C which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane%3B Belongs to the LapB family%3B Contains 7 TPR repeats gene gene1198 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01199 VSVS12_01200 VSVS12_01200 pyrF pyrF 1256728 1257423 + Orotidine-5'-phosphate decarboxylase Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP)%3B Belongs to the OMP decarboxylase family. Type 1 subfamily%3B KEGG: vvu:VV1_2977 orotidine-5'-phosphate decarboxylase gene gene1199 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01200 VSVS12_01201 VSVS12_01201 VSVS12_01201 1257577 1258341 - hypothetical protein gene gene1200 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01201 VSVS12_01202 VSVS12_01202 VSVS12_01202 1258693 1259667 + HTH-type transcriptional regulator This protein is a positive regulator of gene expression for the cysteine regulon. The inducer for CysB is N-acetylserine (By similarity)%3B Contains 1 HTH lysR-type DNA-binding domain gene gene1201 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01202 VSVS12_01203 VSVS12_01203 VSVS12_01203 1259736 1260929 + hypothetical protein gene gene1202 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01203 VSVS12_01204 VSVS12_01204 VSVS12_01204 1261160 1262125 + hypothetical protein gene gene1203 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01204 VSVS12_01205 VSVS12_01205 VSVS12_01205 1262228 1263163 + hypothetical protein gene gene1204 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01205 VSVS12_01206 VSVS12_01206 VSVS12_01206 1263160 1263630 + Energy-coupling factor transporter ATP-binding protein EcfA1 ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates%3B Belongs to the ABC transporter superfamily. Energy- coupling factor EcfA family%3B Contains 1 ABC transporter domain gene gene1205 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01206 VSVS12_01207 VSVS12_01207 VSVS12_01207 1263639 1263953 + Methionine import ATP-binding protein MetN Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system%3B Belongs to the ABC transporter superfamily. Methionine importer (TC 3. A. 1. 24) family%3B Contains 1 ABC transporter domain gene gene1206 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01207 VSVS12_01208 VSVS12_01208 dusC dusC 1264079 1265029 - tRNA-dihydrouridine(16) synthase Catalyzes the synthesis of 5%2C6-dihydrouridine (D)%2C a modified base found in the D-loop of most tRNAs%2C via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U16 in tRNAs%3B Belongs to the Dus family. DusC subfamily%3B KEGG: eco:b2140 tRNA-dihydrouridine synthase C%3B Oxidoreductases gene gene1207 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01208 VSVS12_01209 VSVS12_01209 VSVS12_01209 1265120 1265689 - hypothetical protein gene gene1208 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01209 VSVS12_01210 VSVS12_01210 VSVS12_01210 1265893 1266507 + Protein translocase subunit SecA Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane%2C serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane%3B Belongs to the SecA family gene gene1209 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01210 VSVS12_01211 VSVS12_01211 VSVS12_01211 1266635 1267231 + Outer-membrane lipoprotein carrier protein Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)%3B Belongs to the LolA family gene gene1210 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01211 VSVS12_01212 VSVS12_01212 VSVS12_01212 1267235 1268584 + Replication-associated recombination protein DNA-dependent ATPase that plays important roles in cellular responses to stalled DNA replication processes%3B Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily gene gene1211 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01212 VSVS12_01213 VSVS12_01213 sarS sarS 1268676 1269983 + Serine--tRNA ligase Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine%2C to form the misacylated tRNA L-seryl-tRNA(Sec)%2C which will be further converted into selenocysteinyl-tRNA(Sec)%3B Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily%3B KEGG: vch:VC1110 seryl-tRNA synthetase gene gene1212 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01213 VSVS12_01214 VSVS12_01214 VSVS12_01214 1270111 1270203 + hypothetical protein gene gene1213 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01214 VSVS12_01215 VSVS12_01215 VSVS12_01215 1270205 1270759 + Maltose O-acetyltransferase May assist cellular detoxification by acetylating non- metabolizable pyranosides%2C thereby preventing their reentry into the cell. Belongs to the transferase hexapeptide repeat family%3B KEGG: van:VAA_02970 maltose O-acetyltransferase gene gene1214 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01215 VSVS12_01216 VSVS12_01216 VSVS12_01216 1270911 1271798 + hypothetical protein gene gene1215 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01216 VSVS12_01217 VSVS12_01217 ansA ansA 1271854 1272870 - Asparaginase Belongs to the asparaginase 1 family%3B Contains 1 asparaginase/glutaminase domain%3B KEGG: vsp:VS_0936 L-asparaginase gene gene1216 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01217 VSVS12_01218 VSVS12_01218 sppA sppA 1273016 1274866 - Protease Digests cleaved signal peptides in vitro%2C its in vivo function is unknown. This activity is necessary to maintain proper secretion of mature proteins across the membrane%3B Belongs to the peptidase S49 family%3B KEGG: eae:EAE_21690 protease IV%3B Serine endopeptidases gene gene1217 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01218 VSVS12_01219 VSVS12_01219 fadH fadH 1275204 1277207 + 2%2C4-dienoyl-CoA reductase (NADPH) KEGG: vpa:VP2151 2%2C4-dienoyl-CoA reductase (NADPH2) gene gene1218 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01219 VSVS12_01220 VSVS12_01220 VSVS12_01220 1277279 1277860 - hypothetical protein gene gene1219 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01220 VSVS12_01221 VSVS12_01221 purU purU 1278067 1278900 - Formyltetrahydrofolate deformylase Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4)%3B Belongs to the PurU family%3B Contains 1 ACT domain%3B KEGG: vch:VC1992 formyltetrahydrofolate deformylase gene gene1220 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01221 VSVS12_01222 VSVS12_01222 VSVS12_01222 1279101 1279301 + hypothetical protein gene gene1221 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01222 VSVS12_01223 VSVS12_01223 dinG dinG 1279555 1281486 + DNA helicase Belongs to the helicase family. DinG subfamily%3B Contains 1 helicase ATP-binding domain%3B KEGG: vch:VC1990 ATP-dependent DNA helicase DinG gene gene1222 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01223 VSVS12_01224 VSVS12_01224 VSVS12_01224 1281495 1282196 + tRNA threonylcarbamoyladenosine biosynthesis protein TsaB Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37%2C together with TsaD and Tsa%3B this reaction does not require ATP in vitro. TsaB seems to play an indirect role in the t(6)A biosynthesis pathway%2C possibly in regulating the core enzymatic function of TsaD (By similarity)%3B Belongs to the KAE1 / TsaD family. TsaB subfamily gene gene1223 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01224 VSVS12_01225 VSVS12_01225 VSVS12_01225 1282238 1282540 + hypothetical protein gene gene1224 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01225 VSVS12_01226 VSVS12_01226 VSVS12_01226 1282601 1283158 + hypothetical protein gene gene1225 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01226 VSVS12_01227 VSVS12_01227 VSVS12_01227 1283159 1284004 + Abhydrolase domain-containing protein Belongs to the AB hydrolase superfamily gene gene1226 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01227 VSVS12_01228 VSVS12_01228 acsL acsL 1284134 1285852 + Long-chain-fatty-acid--CoA ligase Catalyzes the esterification%2C concomitant with transport%2C of exogenous long-chain fatty acids into metabolically active CoA thioesters for subsequent degradation or incorporation into phospholipids%3B Belongs to the ATP-dependent AMP-binding enzyme family%3B KEGG: vch:VC1985 long-chain acyl-CoA synthetase gene gene1227 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01228 VSVS12_01229 VSVS12_01229 VSVS12_01229 1285923 1287041 + Ribonuclease D Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides%3B Belongs to the RNase D family%3B Contains 1 3'-5' exonuclease domain%3B Contains 1 HRDC domain%3B KEGG: esc:Entcl_1988 ribonuclease D gene gene1228 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01229 VSVS12_01230 VSVS12_01230 VSVS12_01230 1287288 1289990 + hypothetical protein gene gene1229 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01230 VSVS12_01231 VSVS12_01231 VSVS12_01231 1290062 1291660 - Cardiolipin synthase Catalyzes the synthesis of cardiolipin (CL) (diphosphatidylglycerol) from phosphatidylglycerol (PG) and phosphatidylethanolamine (PE). Belongs to the phospholipase D family. Cardiolipin synthase subfamily. ClsC sub-subfamily%3B Contains 2 PLD phosphodiesterase domains%3B KEGG: bli:BL04039 cardiolipin synthase%3B Transferases for other substituted phosphate groups gene gene1230 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01231 VSVS12_01232 VSVS12_01232 VSVS12_01232 1291912 1293471 - Sulfate transporter 3.1 H(+)/sulfate cotransporter that may play a role in the regulation of sulfate assimilation. Belongs to the SLC26A/SulP transporter (TC 2. A. 53) family%3B Contains 1 STAS domain gene gene1231 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01232 VSVS12_01233 VSVS12_01233 VSVS12_01233 1293767 1296901 - Ribonuclease E Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs%3B Belongs to the RNase E/G family. RNase E subfamily%3B Contains 1 S1 motif domain%3B KEGG: eco:b1084 ribonuclease E gene gene1232 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01233 VSVS12_01234 VSVS12_01234 rluC rluC 1297459 1298403 + 23S rRNA pseudouridine(955/2504/2580) synthase Responsible for synthesis of pseudouridine from uracil at positions 955%2C 2504 and 2580 in 23S ribosomal RNA%3B Belongs to the pseudouridine synthase RluA family%3B Contains 1 S4 RNA-binding domain%3B KEGG: vch:VC2028 23S rRNA pseudouridine955/2504/2580 synthase gene gene1233 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01234 VSVS12_01235 VSVS12_01235 VSVS12_01235 1298564 1299160 - Maf-like protein Belongs to the maf family gene gene1234 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01235 VSVS12_01236 VSVS12_01236 VSVS12_01236 1299309 1299836 + uncharacterized protein To E. coli YceD gene gene1235 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01236 VSVS12_01237 VSVS12_01237 VSVS12_01237 1299885 1300055 + 50S ribosomal protein L32 Belongs to the ribosomal protein L32P family gene gene1236 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01237 VSVS12_01238 VSVS12_01238 plsX plsX 1300065 1301090 + Glycerol-3-phosphate 1-O-acyltransferase Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor%2C but not acyl-CoA%3B Belongs to the PlsX family%3B KEGG: plu:plu2836 glycerol-3-phosphate acyltransferase PlsX gene gene1237 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01238 VSVS12_01239 VSVS12_01239 fabH fabH 1301096 1302049 + Beta-ketoacyl-[acyl-carrier-protein] synthase III Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and/or straight-chain of fatty acids%3B Belongs to the FabH family%3B KEGG: eco:b1091 3-oxoacyl-(acyl-carrier-protein) synthase III gene gene1238 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01239 VSVS12_01240 VSVS12_01240 fabD fabD 1302122 1303045 + [Acyl-carrier-protein] S-malonyltransferase Belongs to the FabD family%3B KEGG: ype:YPO1598 (acyl-carrier-protein) S-malonyltransferase gene gene1239 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01240 VSVS12_01241 VSVS12_01241 fabG fabG 1303078 1303815 + 3-oxoacyl-[acyl-carrier-protein] reductase Belongs to the short-chain dehydrogenases/reductases (SDR) family%3B KEGG: vpb:VPBB_1888 3-oxoacyl-(acyl-carrier protein) reductase gene gene1240 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01241 VSVS12_01242 VSVS12_01242 VSVS12_01242 1304055 1304288 + Acyl carrier protein Carrier of the growing fatty acid chain in fatty acid biosynthesis%3B Contains 1 acyl carrier domain gene gene1241 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01242 VSVS12_01243 VSVS12_01243 fabF fabF 1304382 1305623 + Beta-ketoacyl-[acyl-carrier-protein] synthase II Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP%3B Belongs to the beta-ketoacyl-ACP synthases family%3B KEGG: eco:b1095 3-oxoacyl-(acyl-carrier-protein) synthase II gene gene1242 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01243 VSVS12_01244 VSVS12_01244 pabC pabC 1305758 1306561 + Aminodeoxychorismate lyase Involved in the biosynthesis of p-aminobenzoate (PABA)%2C a precursor of tetrahydrofolate. Converts 4-amino-4- deoxychorismate into 4-aminobenzoate (PABA) and pyruvate (By similarity)%3B Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family%3B KEGG: pay:PAU_01707 4-amino-4-deoxychorismate lyase gene gene1243 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01244 VSVS12_01245 VSVS12_01245 VSVS12_01245 1306558 1307574 + UPF0755 protein YceG Belongs to the UPF0755 family gene gene1244 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01245 VSVS12_01246 VSVS12_01246 VSVS12_01246 1307578 1308210 + dTMP kinase Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis%3B Belongs to the thymidylate kinase family%3B KEGG: vvu:VV1_3002 dTMP kinase gene gene1245 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01246 VSVS12_01247 VSVS12_01247 holB holB 1308210 1309172 + DNA-directed DNA polymerase DNA polymerase III is a complex%2C multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity)%3B KEGG: vcy:IX92_04280 DNA polymerase III subunit delta' gene gene1246 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01247 VSVS12_01248 VSVS12_01248 VSVS12_01248 1309163 1309930 + putative metal-dependent hydrolase Belongs to the TatD-type hydrolase family%3B KEGG: ype:YPO1607 TatD DNase family protein%3B Endodeoxyribonucleases producing 5'-phosphomonoesters gene gene1247 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01248 VSVS12_01249 VSVS12_01249 VSVS12_01249 1310010 1310207 + hypothetical protein gene gene1248 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01249 VSVS12_01250 VSVS12_01250 ptsG ptsG 1310377 1311804 + Protein-N(pi)-phosphohistidine--sugar phosphotransferase The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS)%2C a major carbohydrate active -transport system%2C catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in glucose transport (By similarity)%3B Contains 1 PTS EIIB type-1 domain%3B Contains 1 PTS EIIC type-1 domain%3B KEGG: buc:BU356 PTS system%2C glucose-specific IIB component gene gene1249 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01250 VSVS12_01251 VSVS12_01251 VSVS12_01251 1312143 1312562 + hypothetical protein gene gene1250 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01251 VSVS12_01252 VSVS12_01252 VSVS12_01252 1312673 1312768 - hypothetical protein gene gene1251 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01252 VSVS12_01253 VSVS12_01253 VSVS12_01253 1312771 1314237 - putative sodium-dependent transporter YhdH Putative sodium-dependent transporter%3B Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2. A. 22) family gene gene1252 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01253 VSVS12_01254 VSVS12_01254 VSVS12_01254 1314673 1314915 + hypothetical protein gene gene1253 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01254 VSVS12_01255 VSVS12_01255 VSVS12_01255 1314866 1315387 + hypothetical protein gene gene1254 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01255 VSVS12_01256 VSVS12_01256 VSVS12_01256 1315427 1316071 - hypothetical protein gene gene1255 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01256 VSVS12_01257 VSVS12_01257 VSVS12_01257 1316153 1316245 + hypothetical protein gene gene1256 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01257 VSVS12_01258 VSVS12_01258 VSVS12_01258 1316258 1317418 + uncharacterized protein Probable lipid hydrolase%3B Contains 1 patatin domain gene gene1257 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01258 VSVS12_01259 VSVS12_01259 VSVS12_01259 1317672 1318889 + Protein mlc Transcriptional repressor that regulates the expression of proteins that are part of the phosphotransferase system for sugar uptake. Regulates the expression of malT%3B Belongs to the ROK (NagC/XylR) family gene gene1258 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01259 VSVS12_01260 VSVS12_01260 VSVS12_01260 1318980 1319927 + hypothetical protein gene gene1259 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01260 VSVS12_01261 VSVS12_01261 VSVS12_01261 1320223 1323309 - DNA-directed DNA polymerase DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase%3B Belongs to the DNA polymerase type-C family. DnaE2 subfamily%3B KEGG: vvu:VV1_2989 error-prone DNA polymerase gene gene1260 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01261 VSVS12_01262 VSVS12_01262 VSVS12_01262 1323322 1324728 - hypothetical protein gene gene1261 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01262 VSVS12_01263 VSVS12_01263 VSVS12_01263 1324732 1325409 - hypothetical protein gene gene1262 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01263 VSVS12_01264 VSVS12_01264 VSVS12_01264 1325531 1326274 - putative 2%2C4-dienoyl-CoA reductase Auxiliary enzyme of beta-oxidation. It participates in the metabolism of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions. Catalyzes the NADP-dependent reduction of 2%2C4-dienoyl-CoA to yield trans-3- enoyl-CoA%3B Belongs to the short-chain dehydrogenases/reductases (SDR) family. 2%2C4-dienoyl-CoA reductase subfamily%3B KEGG: cel:CELE_T05C12. 3 null%3B Oxidoreductases gene gene1263 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01264 VSVS12_01265 VSVS12_01265 sohB sohB 1326365 1327426 + putative protease SohB Multicopy suppressor of the HtrA (DegP) null phenotype. It is possibly a protease%2C not essential for bacterial viability. Belongs to the peptidase S49 family%3B KEGG: pmr:PMI1336 serine protease SohB%3B Serine endopeptidases gene gene1264 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01265 VSVS12_01266 VSVS12_01266 VSVS12_01266 1327618 1328472 - Tagatose-bisphosphate aldolase Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3- phosphate (G3P) to form fructose 1%2C6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis%3B Belongs to the class II fructose-bisphosphate aldolase family%3B KEGG: eco:b2096 tagatose 1%2C6-diphosphate aldolase GatY/KbaY gene gene1265 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01266 VSVS12_01267 VSVS12_01267 agaA agaA 1328463 1329656 - N-acetylglucosamine-6-phosphate deacetylase Involved in the first committed step in the biosynthesis of amino-sugar-nucleotides. Catalyzes the hydrolysis of the N- acetyl group of N-acetylglucosamine-6-phosphate (GlcNAc-6-P) to yield glucosamine 6-phosphate and acetate%3B Belongs to the NagA family%3B KEGG: vvu:VV2_1018 N-acetylgalactosamine-6-phosphate deacetylase gene gene1266 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01267 VSVS12_01268 VSVS12_01268 VSVS12_01268 1329646 1330086 - Protein-N(pi)-phosphohistidine--sugar phosphotransferase The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS)%2C a major carbohydrate active -transport system%2C catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in fructose transport. LevD and LevE act as negative regulators of the levanase operon. They may be involved in a PTS-mediated phosphorylation of a regulator. Contains 1 PTS EIIA type-4 domain%3B KEGG: vvu:VV2_1019 PTS system%2C N-acetylgalactosamine-specific IIA component gene gene1267 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01268 VSVS12_01269 VSVS12_01269 VSVS12_01269 1330166 1331050 - N-acetylgalactosamine permease IID component The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS)%2C a major carbohydrate active -transport system%2C catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. This system is involved in N-acetylgalactosamine transport. Contains 1 PTS EIID domain gene gene1268 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01269 VSVS12_01270 VSVS12_01270 VSVS12_01270 1331040 1331822 - Fructose permease IIC component The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS)%2C a major carbohydrate active -transport system%2C catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. This system is involved in fructose transport. Contains 1 PTS EIIC type-4 domain gene gene1269 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01270 VSVS12_01271 VSVS12_01271 VSVS12_01271 1331840 1332313 - Protein-N(pi)-phosphohistidine--sugar phosphotransferase The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS)%2C a major carbohydrate active -transport system%2C catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in N-acetylgalactosamine transport. Contains 1 PTS EIIB type-4 domain%3B KEGG: eco:b3133 PTS system%2C N-acetylgalactosamine-specific IIB component gene gene1270 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01271 VSVS12_01272 VSVS12_01272 agaS agaS 1332336 1333493 - D-galactosamine-6-phosphate deaminase AgaS Involved in the pathway of N-acetyl-D-galactosamine degradation. Catalyzes the conversion of D-galactosamine 6- phosphate (GalN-6-P) to D-tagatofuranose 6-phosphate (Tag-6-P). It can also catalyze the conversion of D-glucosamine 6-phosphate%3B Contains 2 SIS domains%3B KEGG: sod:Sant_0727 tagatose-6-phosphate ketose/aldose isomerase%3B Isomerases gene gene1271 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01272 VSVS12_01273 VSVS12_01273 VSVS12_01273 1333493 1334800 - D-tagatose-1%2C6-bisphosphate aldolase subunit KbaZ Component of the tagatose-1%2C6-bisphosphate aldolase KbaYZ that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of KbaY. When expressed alone%2C KbaZ does not show any aldolase activity%3B Belongs to the GatZ/KbaZ family. KbaZ subfamily gene gene1272 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01273 VSVS12_01274 VSVS12_01274 VSVS12_01274 1334809 1335585 - putative HTH-type transcriptional regulator Contains 1 HTH deoR-type DNA-binding domain gene gene1273 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01274 VSVS12_01275 VSVS12_01275 VSVS12_01275 1336383 1336595 + Cold shock-like protein CspG Contains 1 CSD (cold-shock) domain gene gene1274 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01275 VSVS12_01276 VSVS12_01276 VSVS12_01276 1337009 1337098 + hypothetical protein gene gene1275 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01276 VSVS12_01277 VSVS12_01277 VSVS12_01277 1337095 1337304 + hypothetical protein gene gene1276 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01277 VSVS12_01278 VSVS12_01278 VSVS12_01278 1337361 1338134 - Putative aga operon transcriptional repressor Probable repressor for the aga operon for N-acetyl galactosamine transport and metabolism%3B Contains 1 HTH deoR-type DNA-binding domain gene gene1277 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01278 VSVS12_01279 VSVS12_01279 VSVS12_01279 1338234 1338515 - hypothetical protein gene gene1278 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01279 VSVS12_01280 VSVS12_01280 VSVS12_01280 1338777 1339391 + hypothetical protein gene gene1279 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01280 VSVS12_01281 VSVS12_01281 VSVS12_01281 1339457 1340773 - dGTPase Belongs to the dGTPase family. Type 2 subfamily%3B KEGG: vtu:IX91_10045 dGTPase gene gene1280 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01281 VSVS12_01282 VSVS12_01282 yfbR yfbR 1340816 1341400 - 5'-deoxynucleotidase Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates%3B Belongs to the 5DNU family%3B KEGG: eco:b2291 5'-deoxynucleotidase gene gene1281 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01282 VSVS12_01283 VSVS12_01283 alaA alaA 1341493 1342707 - Valine--pyruvate transaminase Involved in the biosynthesis of alanine%3B Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family%3B KEGG: vch:VC1977 alanine-synthesizing transaminase gene gene1282 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01283 VSVS12_01284 VSVS12_01284 menF menF 1343179 1344486 + Isochorismate synthase Involved in the synthesis of salicylic acid (SA) required for both local and systemic acquired resistance (LAR and SAR) while SA synthesized through the phenylalanine ammonium lyase (PAL) pathway seems to potentiate plant cell death. Also involved in phylloquinone (vitamin K1) synthesis. Has no isochorismate pyruvate lyase (IPL) activity%3B Belongs to the isochorismate synthase family%3B KEGG: vsp:VS_2192 menaquinone-specific isochorismate synthase gene gene1283 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01284 VSVS12_01285 VSVS12_01285 menD menD 1344483 1346222 + 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acidsynthase Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)%3B Belongs to the TPP enzyme family. MenD subfamily%3B KEGG: vch:VC1975 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase gene gene1284 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01285 VSVS12_01286 VSVS12_01286 menH menH 1346209 1347000 + 2-succinyl-6-hydroxy-2%2C4-cyclohexadiene-1-carboxylate synthase Catalyzes a proton abstraction reaction that results in 2%2C5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2%2C4-cyclohexadiene-1-carboxylate (SHCHC)%3B Belongs to the AB hydrolase superfamily. MenH family%3B KEGG: ebi:EbC_30510 2-succinyl-6-hydroxy-2%2C4-cyclohexadiene-1-carboxylate synthase gene gene1285 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01286 VSVS12_01287 VSVS12_01287 menB menB 1347022 1347888 + 1%2C4-dihydroxy-2-naphthoyl-CoA synthase Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1%2C4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)%3B Belongs to the enoyl-CoA hydratase/isomerase family. MenB subfamily%3B KEGG: vvu:VV1_3170 naphthoate synthase gene gene1286 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01287 VSVS12_01288 VSVS12_01288 menC menC 1348062 1349051 + o-succinylbenzoate synthase Converts 2-succinyl-6-hydroxy-2%2C4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB)%3B Belongs to the mandelate racemase/muconate lactonizing enzyme family. MenC type 1 subfamily%3B KEGG: hdu:HD1055 O-succinylbenzoate synthase gene gene1287 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01288 VSVS12_01289 VSVS12_01289 menE menE 1349051 1350460 + o-succinylbenzoate--CoA ligase Converts 2-succinylbenzoate (OSB) to 2-succinylbenzoyl- CoA (OSB-CoA)%3B Belongs to the ATP-dependent AMP-binding enzyme family. MenE subfamily%3B KEGG: xne:XNC1_2849 O-succinylbenzoic acid--CoA ligase gene gene1288 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01289 VSVS12_01290 VSVS12_01290 nagE nagE 1350658 1352124 - Protein-N(pi)-phosphohistidine--sugar phosphotransferase The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS)%2C a major carbohydrate active -transport system%2C catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in N-acetylglucosamine transport. Contains 1 PTS EIIA type-1 domain%3B Contains 1 PTS EIIB type-1 domain%3B Contains 1 PTS EIIC type-1 domain%3B KEGG: ype:YPO2628 PTS system%2C N-acetylglucosamine-specific IIA component gene gene1289 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01290 VSVS12_01291 VSVS12_01291 VSVS12_01291 1352315 1353193 + HTH-type transcriptional regulator DsdC Regulates the expression of the dsd operon for D-serine deaminase (dsdA)%3B Contains 1 HTH lysR-type DNA-binding domain gene gene1290 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01291 VSVS12_01292 VSVS12_01292 VSVS12_01292 1353284 1353457 + hypothetical protein gene gene1291 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01292 VSVS12_01293 VSVS12_01293 VSVS12_01293 1353479 1354402 - UPF0324 membrane protein Belongs to the UPF0324 family gene gene1292 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01293 VSVS12_01294 VSVS12_01294 VSVS12_01294 1354558 1356432 - hypothetical protein gene gene1293 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01294 VSVS12_01295 VSVS12_01295 VSVS12_01295 1356449 1357039 - hypothetical protein gene gene1294 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01295 VSVS12_01296 VSVS12_01296 VSVS12_01296 1357248 1358126 + hypothetical protein gene gene1295 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01296 VSVS12_01297 VSVS12_01297 VSVS12_01297 1358241 1358561 + hypothetical protein gene gene1296 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01297 VSVS12_01298 VSVS12_01298 VSVS12_01298 1358694 1359761 - Cysteine synthase Belongs to the cysteine synthase/cystathionine beta- synthase family%3B KEGG: vch:VC1061 cysteine synthase A gene gene1297 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01298 VSVS12_01299 VSVS12_01299 VSVS12_01299 1359888 1360346 + HTH-type transcriptional regulator LrpA Negative regulation of glyA transcription and kinB- dependent sporulation%3B Contains 1 HTH asnC-type DNA-binding domain gene gene1298 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01299 VSVS12_01300 VSVS12_01300 tesB tesB 1360378 1361241 - Acyl-CoA thioesterase Can hydrolyze a broad range of acyl-CoA thioesters. Its physiological function is not known (By similarity)%3B Belongs to the C/M/P thioester hydrolase family%3B KEGG: vch:VC1063 acyl-CoA thioesterase II%3B Thiolester hydrolases gene gene1299 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01300 VSVS12_01301 VSVS12_01301 VSVS12_01301 1361464 1361895 + putative lipoprotein YbaY gene gene1300 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01301 VSVS12_01302 VSVS12_01302 VSVS12_01302 1361937 1362245 - DNA base-flipping protein Involved in DNA damage recognition. Binds DNA containing O(6)-methylguanine (PubMed:20212037). Binds to the damaged base and flips the base out of the DNA duplex into an extrahelical conformation%2C which allows processing by repair proteins (By similarity)%3B Belongs to the MGMT family. ATL subfamily gene gene1301 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01302 VSVS12_01303 VSVS12_01303 VSVS12_01303 1362365 1363105 + hypothetical protein gene gene1302 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01303 VSVS12_01304 VSVS12_01304 VSVS12_01304 1363263 1365302 + Diguanylate cyclase KEGG: lfi:LFML04_0741 two-component system%2C cell cycle response regulator gene gene1303 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01304 VSVS12_01305 VSVS12_01305 VSVS12_01305 1365783 1366838 + IgA-specific serine endopeptidase KEGG: llm:llmg_0877 IgA-specific serine endopeptidase gene gene1304 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01305 VSVS12_01306 VSVS12_01306 VSVS12_01306 1366950 1371377 - Putative lipoprotein AcfD like protein Contains 1 peptidase M60 domain%3B To V. cholerae AcfD (VC_0845) gene gene1305 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01306 VSVS12_01307 VSVS12_01307 VSVS12_01307 1371805 1373421 - hypothetical protein gene gene1306 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01307 VSVS12_01308 VSVS12_01308 vieA vieA 1373428 1375167 - Cyclic-guanylate-specific phosphodiesterase Photoreceptor which exists in two forms that are reversibly interconvertible by light: the R form that absorbs maximally in the red region of the spectrum and the FR form that absorbs maximally in the far-red region. Belongs to the phytochrome family%3B Contains 1 EAL domain%3B Contains 2 GAF domains%3B Contains 2 GGDEF domains%3B KEGG: vch:VC1652 c-di-GMP phosphodiesterase gene gene1307 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01308 VSVS12_01309 VSVS12_01309 evgS evgS 1375170 1378721 - Histidine kinase Ethylene receptor related to bacterial two-component regulators. Acts as a redundant negative regulator of ethylene signaling. Belongs to the ethylene receptor family%3B Contains 1 GAF domain%3B Contains 1 histidine kinase domain%3B KEGG: van:VAA_03253 two-component system%2C NarL family%2C sensor histidine kinase EvgS gene gene1308 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01309 VSVS12_01310 VSVS12_01310 VSVS12_01310 1378907 1379797 - HTH-type transcriptional regulator DmlR Transcriptional regulator required for the aerobic growth on D-malate as the sole carbon source. Induces the expression of dmlA in response to D-malate or L- or meso-tartrate. Negatively regulates its own expression%3B Contains 1 HTH lysR-type DNA-binding domain gene gene1309 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01310 VSVS12_01311 VSVS12_01311 isfD isfD 1380055 1380774 + Sulfoacetaldehyde reductase Belongs to the short-chain dehydrogenases/reductases (SDR) family%3B KEGG: pge:LG71_22100 sulfoacetaldehyde reductase gene gene1310 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01311 VSVS12_01312 VSVS12_01312 VSVS12_01312 1381324 1382952 + Periplasmic murein peptide-binding protein Essential for the uptake of the murein peptide L-alanyl- gamma-D-glutamyl-meso-diaminopimelate. Also transports some alpha- linked peptides such as Pro-Phe-Lys with low affinity. The transport is effected by the oligopeptide permease system. Belongs to the bacterial solute-binding protein 5 family gene gene1311 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01312 VSVS12_01313 VSVS12_01313 VSVS12_01313 1383118 1384038 + Dipeptide transport system permease protein DppB Part of the binding-protein-dependent transport system for dipeptide%3B probably responsible for the translocation of the substrate across the membrane. Is expressed to facilitate adaptation to nutrient deficiency conditions. Belongs to the binding-protein-dependent transport system permease family. OppBC subfamily%3B Contains 1 ABC transmembrane type-1 domain gene gene1312 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01313 VSVS12_01314 VSVS12_01314 VSVS12_01314 1384048 1384956 + Oligopeptide transport system permease protein Part of the binding-protein-dependent transport system for oligopeptide%3B probably responsible for the translocation of the substrate across the membrane%3B Belongs to the binding-protein-dependent transport system permease family. OppBC subfamily%3B Contains 1 ABC transmembrane type-1 domain gene gene1313 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01314 VSVS12_01315 VSVS12_01315 VSVS12_01315 1384986 1385957 + Dipeptide transport ATP-binding protein DppD Part of the binding-protein-dependent transport system for dipeptides. Probably responsible for energy coupling to the transport system (By similarity)%3B Belongs to the ABC transporter superfamily%3B Contains 1 ABC transporter domain gene gene1314 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01315 VSVS12_01316 VSVS12_01316 VSVS12_01316 1385954 1386946 + Oligopeptide transport ATP-binding protein OppF Part of the binding-protein-dependent transport system for oligopeptides. Probably responsible for energy coupling to the transport system. Belongs to the ABC transporter superfamily%3B Contains 1 ABC transporter domain gene gene1315 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01316 VSVS12_01317 VSVS12_01317 VSVS12_01317 1387206 1388234 + Spermidine/putrescine-binding periplasmic protein Required for the activity of the bacterial periplasmic transport system of putrescine and spermidine. Polyamine binding protein (By similarity)%3B Belongs to the bacterial solute-binding protein PotD/PotF family gene gene1316 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01317 VSVS12_01318 VSVS12_01318 VSVS12_01318 1388234 1389277 + Histone deacetylase Acts on many types of acetylpolyamines. Has high affinity towards acetylputrescine%2C acetylcadaverine%2C acetylspermidine%2C and acetylspermine. Acts on L-Lys-(epsilon- acetyl)-coumarin%2C but has very low activity towards acetylated peptides. Belongs to the histone deacetylase family%3B KEGG: ccw:104683746 histone deacetylase 7 gene gene1317 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01318 VSVS12_01319 VSVS12_01319 VSVS12_01319 1389469 1390413 + Glutathionyl-hydroquinone reductase YqjG Catalyzes glutathione (GSH)-dependent reduction of glutathionyl-hydroquinones (GS-HQs) to the corresponding hydroquinones. Can use a variety of GS-HQs as substrates%2C such as GS-p-hydroquinone (GS-HQ)%2C GS-hydroxy-p-hydroquinone (GS-HHQ)%2C GS- methyl-p-hydroquinone (GS-MHQ)%2C GS-menadiol%2C and GS-trichloro-p- hydroquinone (GS-TriCH). Also displays GSH-dependent disulfide- bond reduction activity toward HED (2-hydroxyethyl disulfide)%2C and is able to catalyze DMA (dimethylarsinate) reduction. Exhibits no GSH transferase activity with 1-chloro-2%2C4-dinitrobenzene (CDNB)%3B Belongs to the GST superfamily. Xi-class GSH transferase family%3B Contains 1 GST C-terminal domain gene gene1318 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01319 VSVS12_01320 VSVS12_01320 VSVS12_01320 1390801 1391301 + hypothetical protein gene gene1319 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01320 VSVS12_01321 VSVS12_01321 VSVS12_01321 1391288 1391854 + hypothetical protein gene gene1320 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01321 VSVS12_01322 VSVS12_01322 VSVS12_01322 1391854 1392702 + hypothetical protein gene gene1321 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01322 VSVS12_01323 VSVS12_01323 VSVS12_01323 1392677 1393066 + hypothetical protein gene gene1322 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01323 VSVS12_01324 VSVS12_01324 VSVS12_01324 1393063 1399956 + hypothetical protein gene gene1323 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01324 VSVS12_01325 VSVS12_01325 VSVS12_01325 1400099 1400692 - hypothetical protein gene gene1324 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01325 VSVS12_01326 VSVS12_01326 VSVS12_01326 1400880 1401995 + UPF0194 membrane protein YbhG Belongs to the UPF0194 family gene gene1325 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01326 VSVS12_01327 VSVS12_01327 VSVS12_01327 1401995 1405045 + Swarming motility protein SwrC Required for self-resistance to surfactin%2C an antimicrobial lipopeptide surfactant produced by B. subtilis. Also required for swarming motility%3B Belongs to the resistance-nodulation-cell division (RND) (TC 2. A. 6) family gene gene1326 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01327 VSVS12_01328 VSVS12_01328 VSVS12_01328 1405139 1405678 - uncharacterized protein Contains 3 4Fe-4S ferredoxin-type domains gene gene1327 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01328 VSVS12_01329 VSVS12_01329 VSVS12_01329 1405679 1406263 - putative Tat proofreading chaperone DmsD Required for biogenesis/assembly of DMSO reductase%2C but not for the interaction of the DmsA signal peptide with the Tat system. May be part of a chaperone cascade complex that facilitates a folding-maturation pathway for the substrate protein%3B Belongs to the TorD/DmsD family. DmsD subfamily gene gene1328 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01329 VSVS12_01330 VSVS12_01330 dmsA dmsA 1406572 1409016 + Dimethylsulfoxide reductase Catalyzes the reduction of dimethyl sulfoxide (DMSO) to dimethyl sulfide (DMS). DMSO reductase serves as the terminal reductase under anaerobic conditions%2C with DMSO being the terminal electron acceptor. Terminal reductase during anaerobic growth on various sulfoxides and N-oxide compounds. Allows E. coli to grow anaerobically on DMSO as respiratory oxidant%3B Belongs to the prokaryotic molybdopterin-containing oxidoreductase family%3B Contains 1 4Fe-4S Mo/W bis-MGD-type domain%3B KEGG: yel:LC20_03833 anaerobic dimethyl sulfoxide reductase subunit A gene gene1329 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01330 VSVS12_01331 VSVS12_01331 VSVS12_01331 1409026 1409643 + Anaerobic dimethyl sulfoxide reductase chain Electron transfer subunit of the terminal reductase during anaerobic growth on various sulfoxide and N-oxide compounds. Contains 3 4Fe-4S ferredoxin-type domains gene gene1330 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01331 VSVS12_01332 VSVS12_01332 VSVS12_01332 1409645 1410490 + Anaerobic dimethyl sulfoxide reductase chain Terminal reductase during anaerobic growth on various sulfoxide and N-oxide compounds. DmsC anchors the DmsAB dimer to the membrane and stabilizes it. To E. coli YnfH gene gene1331 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01332 VSVS12_01333 VSVS12_01333 VSVS12_01333 1410582 1410833 - hypothetical protein gene gene1332 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01333 VSVS12_01334 VSVS12_01334 VSVS12_01334 1411121 1413274 - Phosphate acetyltransferase Involved in acetate metabolism%3B In the N-terminal sectio%3B belongs to the CobB/CobQ family%3B In the C-terminal sectio%3B belongs to the phosphate acetyltransferase and butyryltransferase family%3B KEGG: ype:YPO2567 phosphate acetyltransferase gene gene1333 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01334 VSVS12_01335 VSVS12_01335 ackA ackA 1413410 1414606 - Acetate kinase Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction%3B Belongs to the acetokinase family%3B KEGG: eic:NT01EI_2694 acetate kinase gene gene1334 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01335 VSVS12_01336 VSVS12_01336 VSVS12_01336 1414969 1415421 + UPF0208 membrane protein Belongs to the UPF0208 family gene gene1335 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01336 VSVS12_01337 VSVS12_01337 VSVS12_01337 1415711 1416025 + hypothetical protein gene gene1336 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01337 VSVS12_01338 VSVS12_01338 VSVS12_01338 1416592 1416882 + Putative transposase InsK for insertion sequence element IS150 Involved in the transposition of the insertion sequence IS150. Belongs to the transposase IS3/IS150/IS904 family%3B Contains 1 integrase catalytic domain gene gene1337 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01338 VSVS12_01339 VSVS12_01339 pntA pntA 1417031 1418155 - NAD(P)(+) transhydrogenase (Re/Si-specific) May play a role in cell wall synthesis as L-alanine is an important constituent of the peptidoglycan layer%3B Belongs to the AlaDH/PNT family%3B KEGG: esa:ESA_01957 NAD(P) transhydrogenase subunit alpha gene gene1338 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01339 VSVS12_01340 VSVS12_01340 VSVS12_01340 1418312 1418806 + Leucine-responsive regulatory protein Mediates a global response to leucine. Exogenous leucine affects the expression of a number of different operon%3B lrp mediates this effect for at least some of these operons. For example it is regulator of the branched-chain amino acid transport genes (By similarity)%3B Contains 1 HTH asnC-type DNA-binding domain gene gene1339 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01340 VSVS12_01341 VSVS12_01341 VSVS12_01341 1419050 1422106 + DNA translocase FtsK Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site%2C which is located within the replication terminus region. Translocation stops specifically at Xer-dif sites%2C where FtsK interacts with the Xer recombinase%2C allowing activation of chromosome unlinking by recombination. FtsK orienting polar sequences (KOPS) guide the direction of DNA translocation. FtsK can remove proteins from DNA as it translocates%2C but translocation stops specifically at XerCD-dif site%2C thereby preventing removal of XerC and XerD from dif (By similarity)%3B Belongs to the FtsK/SpoIIIE/SftA family%3B Contains 1 FtsK domain gene gene1340 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01341 VSVS12_01342 VSVS12_01342 VSVS12_01342 1422393 1422914 - Disulfide bond formation protein B Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein%3B Belongs to the DsbB family gene gene1341 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01342 VSVS12_01343 VSVS12_01343 VSVS12_01343 1422997 1424583 - Na(+)/H(+) antiporter NhaB Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons%3B Belongs to the NhaB Na(+)/H(+) (TC 2. A. 34) antiporter family gene gene1342 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01343 VSVS12_01344 VSVS12_01344 VSVS12_01344 1425221 1426060 + Fatty acid metabolism regulator protein Multifunctional regulator of fatty acid metabolism%3B Contains 1 HTH gntR-type DNA-binding domain gene gene1343 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01344 VSVS12_01345 VSVS12_01345 VSVS12_01345 1426143 1427219 - Flavohemoprotein Is involved in NO detoxification in an aerobic process%2C termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate%2C which protects the bacterium from various noxious nitrogen compounds. Therefore%2C plays a central role in the inducible response to nitrosative stress%3B Belongs to the globin family. Two-domain flavohemoproteins subfamily%3B In the C-terminal sectio%3B belongs to the flavoprotein pyridine nucleotide cytochrome reductase family%3B Contains 1 FAD-binding FR-type domain%3B KEGG: vpa:VP1188 NADH oxidoreductase Hcr%3B Oxidoreductases gene gene1344 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01345 VSVS12_01346 VSVS12_01346 VSVS12_01346 1427380 1429041 - Hydroxylamine reductase Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O%3B Belongs to the HCP family%3B KEGG: eco:b0873 hydroxylamine reductase gene gene1345 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01346 VSVS12_01347 VSVS12_01347 VSVS12_01347 1429248 1430807 - Regulatory protein LuxO Involved in the regulation of different processes depending on the cell density. Acts together with sigma-54 to repress%2C perhaps indirectly%2C some genes. Contains 1 sigma-54 factor interaction domain gene gene1346 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01347 VSVS12_01348 VSVS12_01348 VSVS12_01348 1430971 1432140 - hypothetical protein gene gene1347 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01348 VSVS12_01349 VSVS12_01349 VSVS12_01349 1432291 1434282 - Toxin coregulated pilus biosynthesis protein May function as an environmental regulator of TCP biogenesis. Negatively regulates the synthesis of the major pilin subunit of TCP (TcpA) (By similarity)%3B Contains 1 methyl-accepting transducer domain gene gene1348 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01349 VSVS12_01350 VSVS12_01350 VSVS12_01350 1434504 1434854 + HIT-like protein HinT Hydrolyzes purine nucleotide phosphoramidates%2C including adenosine 5'monophosphoramidate (AMP-NH2)%2C adenosine 5'monophosphomorpholidate (AMP-morpholidate)%2C guanosine 5'monophosphomorpholidate (GMP-morpholidate) and tryptamine 5'guanosine monophosphate (TpGd). Hydrolyzes lysyl-AMP (AMP-N- epsilon-(N-alpha-acetyl lysine methyl ester)) generated by lysine tRNA ligase and lysyl-GMP (GMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)). Required for growth at high salt concentrations. Required for normal DadA activity and the ability to grow with D%2CL-alanine as carbon source (By similarity)%3B Belongs to the HINT family%3B Contains 1 HIT domain gene gene1349 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01350 VSVS12_01351 VSVS12_01351 VSVS12_01351 1434929 1436335 + hypothetical protein gene gene1350 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01351 VSVS12_01352 VSVS12_01352 VSVS12_01352 1436335 1436724 + hypothetical protein gene gene1351 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01352 VSVS12_01353 VSVS12_01353 VSVS12_01353 1436787 1437377 + Penicillin-binding protein activator LpoB Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)%3B Belongs to the LpoB family gene gene1352 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01353 VSVS12_01354 VSVS12_01354 thiK thiK 1437423 1438292 + Thiamine kinase KEGG: eno:ECENHK_08640 thiamine kinase gene gene1353 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01354 VSVS12_01355 VSVS12_01355 VSVS12_01355 1438442 1438981 + UPF0227 protein Belongs to the UPF0227 family gene gene1354 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01355 VSVS12_01356 VSVS12_01356 VSVS12_01356 1439450 1440739 + NADH dehydrogenase Transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Does not couple the redox reaction to proton translocation. Belongs to the NADH dehydrogenase family%3B KEGG: eco:b1109 NADH dehydrogenase gene gene1355 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01356 VSVS12_01357 VSVS12_01357 rimJ rimJ 1440807 1441346 - Ribosomal-protein-alanine N-acetyltransferase KEGG: pste:PSTEL_22215 ribosomal-protein-alanine N-acetyltransferase gene gene1356 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01357 VSVS12_01358 VSVS12_01358 VSVS12_01358 1441534 1442301 - hypothetical protein gene gene1357 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01358 VSVS12_01359 VSVS12_01359 VSVS12_01359 1442338 1445802 - Transcription-repair-coupling factor Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA%2C and recruitment of nucleotide excision repair machinery to the damaged site. Can also dissociate RNAP that is blocked by low concentration of nucleoside triphosphates or by physical obstruction%2C such as bound proteins. In addition%2C can rescue arrested complexes by promoting forward translocation. Has ATPase activity%2C which is required for removal of stalled RNAP%2C but seems to lack helicase activity. May act through a translocase activity that rewinds upstream DNA%2C leading either to translocation or to release of RNAP when the enzyme active site can not continue elongation%3B In the N-terminal sectio%3B belongs to the UvrB family%3B In the C-terminal sectio%3B belongs to the helicase family. RecG subfamily%3B Contains 1 helicase ATP-binding domain%3B Contains 1 helicase C-terminal domain%3B KEGG: vvu:VV1_2078 transcription-repair coupling factor (superfamily II helicase)%3B Acting on ATP%3B involved in cellular and subcellular movement gene gene1358 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01359 VSVS12_01360 VSVS12_01360 VSVS12_01360 1445812 1446378 - hypothetical protein gene gene1359 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01360 VSVS12_01361 VSVS12_01361 VSVS12_01361 1446555 1447763 + Lipoprotein-releasing system transmembrane protein LolC Part of an ATP-dependent transport system responsible for the release of lipoproteins targeted to the outer membrane from the inner membrane. Such a release is dependent of the sorting-signal (absence of an Asp at position 2 of the mature lipoprotein) and of LolA (By similarity)%3B Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily gene gene1360 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01361 VSVS12_01362 VSVS12_01362 lolD lolD 1447756 1448442 + Macrolide export ATP-binding/permease protein MacB Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD)%2C which form a pore in the inner membrane%2C and an ATP-binding domain (NBD)%2C which is responsible for energy generation. Confers resistance against macrolides%3B Belongs to the ABC transporter superfamily. Macrolide exporter (TC 3. A. 1. 122) family%3B Contains 1 ABC transporter domain%3B KEGG: amac:MASE_07760 lipoprotein-releasing system ATP-binding protein%3B Acting on acid anhydrides%3B catalyzing transmembrane movement of substances gene gene1361 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01362 VSVS12_01363 VSVS12_01363 VSVS12_01363 1448442 1449686 + Lipoprotein-releasing system transmembrane protein LolC Part of an ATP-dependent transport system responsible for the release of lipoproteins targeted to the outer membrane from the inner membrane. Such a release is dependent of the sorting-signal (absence of an Asp at position 2 of the mature lipoprotein) and of LolA (By similarity)%3B Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily gene gene1362 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01363 VSVS12_01364 VSVS12_01364 VSVS12_01364 1449880 1450407 - hypothetical protein gene gene1363 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01364 VSVS12_01365 VSVS12_01365 VSVS12_01365 1450416 1452728 + Recombination protein gene gene1364 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01365 VSVS12_01366 VSVS12_01366 msbA msbA 1452761 1454512 + Lipid A export ATP-binding/permease protein MsbA Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation%3B Belongs to the ABC transporter superfamily. Lipid exporter (TC 3. A. 1. 106) family%3B Contains 1 ABC transmembrane type-1 domain%3B Contains 1 ABC transporter domain%3B KEGG: vcy:IX92_04920 ATP-binding cassette%2C subfamily B%2C bacterial MsbA%3B Acting on acid anhydrides%3B catalyzing transmembrane movement of substances gene gene1365 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01366 VSVS12_01367 VSVS12_01367 lpxK lpxK 1454516 1455523 + Tetraacyldisaccharide 4'-kinase Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1%2C4'-bis-phosphate (lipid IVA)%3B Belongs to the LpxK family%3B KEGG: vvu:VV1_2086 tetraacyldisaccharide 4'-kinase gene gene1366 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01367 VSVS12_01368 VSVS12_01368 VSVS12_01368 1455504 1455683 + UPF0434 protein Belongs to the UPF0434 family gene gene1367 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01368 VSVS12_01369 VSVS12_01369 kdsB kdsB 1455683 1456432 + 3-deoxy-manno-octulosonate cytidylyltransferase Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria%3B Belongs to the KdsB family%3B KEGG: eca:ECA2554 3-deoxy-manno-octulosonate cytidylyltransferase (CMP-KDO synthetase) gene gene1368 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01369 VSVS12_01370 VSVS12_01370 VSVS12_01370 1456494 1458032 - uncharacterized protein To B. subtilis SpoVR gene gene1369 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01370 VSVS12_01371 VSVS12_01371 VSVS12_01371 1458042 1459313 - UPF0229 protein Belongs to the UPF0229 family gene gene1370 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01371 VSVS12_01372 VSVS12_01372 VSVS12_01372 1459409 1461343 - uncharacterized protein Belongs to the PrkA family gene gene1371 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01372 VSVS12_01373 VSVS12_01373 VSVS12_01373 1461648 1462430 + MltA-interacting protein May serve as a scaffold protein required for the formation of a complex with MrcB/PonB and MltA%2C this complex could play a role in enlargement and septation of the murein sacculus. Belongs to the MipA/OmpV family gene gene1372 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01373 VSVS12_01374 VSVS12_01374 VSVS12_01374 1462494 1462994 - UPF0304 protein Belongs to the UPF0304 family gene gene1373 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01374 VSVS12_01375 VSVS12_01375 VSVS12_01375 1463291 1464379 + Choloylglycine hydrolase Belongs to the peptidase C59 family%3B KEGG: shl:Shal_0591 choloylglycine hydrolase gene gene1374 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01375 VSVS12_01376 VSVS12_01376 pflA pflA 1464453 1465193 - [Formate-C-acetyltransferase]-activating enzyme Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical%2C using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine. Belongs to the organic radical-activating enzymes family%3B KEGG: vvu:VV1_2095 pyruvate formate lyase activating enzyme gene gene1375 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01376 VSVS12_01377 VSVS12_01377 VSVS12_01377 1465399 1466394 - hypothetical protein gene gene1376 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01377 VSVS12_01378 VSVS12_01378 pflD pflD 1466654 1468930 - Formate C-acetyltransferase Contains 1 glycine radical domain%3B Contains 1 PFL domain%3B KEGG: vch:VC1866 formate C-acetyltransferase gene gene1377 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01378 VSVS12_01379 VSVS12_01379 VSVS12_01379 1469231 1470778 - hypothetical protein gene gene1378 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01379 VSVS12_01380 VSVS12_01380 aotP aotP 1471425 1472195 + L-cystine transport system ATP-binding protein YecC Part of the ABC transporter complex FliY-YecC-YecS involved in L-cystine transport. The system can probably also transport L-cysteine%2C and it mediates accumulation of the toxic compounds L-selenaproline (SCA) and L-selenocystine (SeCys) (PubMed:25139244). Probably responsible for energy coupling to the transport system (Probable)%3B Belongs to the ABC transporter superfamily%3B Contains 1 ABC transporter domain%3B KEGG: vch:VC1864 arginine/ornithine transport system ATP-binding protein%3B Acting on acid anhydrides%3B catalyzing transmembrane movement of substances gene gene1379 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01380 VSVS12_01381 VSVS12_01381 VSVS12_01381 1472367 1473134 + Nopaline-binding periplasmic protein Component of the nopaline active transport system probably consisting of four subunits: Q%2C M%2C P and T. This system is also capable of transporting octopine provided that catabolic functions are induced with nopaline. Belongs to the bacterial solute-binding protein 3 family gene gene1380 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01381 VSVS12_01382 VSVS12_01382 VSVS12_01382 1473276 1474016 + Histidine transport system permease protein Part of the histidine permease ABC transporter. Also part of a lysine/arginine/ornithine transporter. Probably responsible for the translocation of the substrate across the membrane. Required to relay the ATPase-inducing signal from the solute-binding protein to HisP (By similarity)%3B Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily%3B Contains 1 ABC transmembrane type-1 domain gene gene1381 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01382 VSVS12_01383 VSVS12_01383 VSVS12_01383 1474020 1474697 + putative amino-acid ABC transporter permease protein PatM Probably part of a binding-protein-dependent transport system for an amino acid. Probably responsible for the translocation of the substrate across the membrane. Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily%3B Contains 1 ABC transmembrane type-1 domain gene gene1382 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01383 VSVS12_01384 VSVS12_01384 VSVS12_01384 1474767 1475609 - putative response regulatory protein Contains 1 HTH LytTR-type DNA-binding domain%3B Contains 1 response regulatory domain gene gene1383 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01384 VSVS12_01385 VSVS12_01385 VSVS12_01385 1475606 1476661 - Sensor protein LytS Member of the two-component regulatory system LytS/LytT that probably regulates genes involved in cell wall metabolism. Contains 1 histidine kinase domain%3B KEGG: vfi:VF_A0733 null%3B Phosphotransferases with a nitrogenous group as acceptor gene gene1384 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01385 VSVS12_01386 VSVS12_01386 VSVS12_01386 1476661 1477944 - hypothetical protein gene gene1385 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01386 VSVS12_01387 VSVS12_01387 VSVS12_01387 1477944 1478723 - hypothetical protein gene gene1386 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01387 VSVS12_01388 VSVS12_01388 VSVS12_01388 1478716 1479981 - ABC transporter permease YtrF Part of the ABC transporter complex YtrBCDEF that plays a role in acetoin utilization during stationary phase and sporulation%3B Belongs to the ABC-4 integral membrane protein family gene gene1387 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01388 VSVS12_01389 VSVS12_01389 VSVS12_01389 1479969 1480667 - Lipoprotein-releasing system ATP-binding protein LolD Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins%2C from the inner membrane to the periplasmic chaperone%2C LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner%3B Belongs to the ABC transporter superfamily. Lipoprotein translocase (TC 3. A. 1. 125) family%3B Contains 1 ABC transporter domain gene gene1388 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01389 VSVS12_01390 VSVS12_01390 VSVS12_01390 1480678 1481328 - hypothetical protein gene gene1389 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01390 VSVS12_01391 VSVS12_01391 VSVS12_01391 1481566 1482150 + hypothetical protein gene gene1390 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01391 VSVS12_01392 VSVS12_01392 VSVS12_01392 1482339 1482767 + hypothetical protein gene gene1391 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01392 VSVS12_01393 VSVS12_01393 VSVS12_01393 1482906 1483148 + hypothetical protein gene gene1392 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01393 VSVS12_01394 VSVS12_01394 VSVS12_01394 1483205 1483465 - hypothetical protein gene gene1393 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01394 VSVS12_01395 VSVS12_01395 VSVS12_01395 1483653 1484363 - DNA-3-methyladenine glycosylase I KEGG: rru:Rru_A1573 DNA-3-methyladenine glycosylase I gene gene1394 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01395 VSVS12_01396 VSVS12_01396 VSVS12_01396 1484440 1485060 - Thiol:disulfide interchange protein DsbA Required for disulfide bond formation in some periplasmic proteins such as PhoA or OmpA. Acts by transferring its disulfide bond to other proteins and is reduced in the process. DsbA is reoxidized by DsbB. It is required for pilus biogenesis. Belongs to the thioredoxin family. DsbA subfamily%3B Contains 1 thioredoxin domain gene gene1395 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01396 VSVS12_01397 VSVS12_01397 VSVS12_01397 1485151 1485516 - hypothetical protein gene gene1396 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01397 VSVS12_01398 VSVS12_01398 VSVS12_01398 1485672 1488497 - hypothetical protein gene gene1397 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01398 VSVS12_01399 VSVS12_01399 VSVS12_01399 1488687 1490651 - hypothetical protein gene gene1398 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01399 VSVS12_01400 VSVS12_01400 VSVS12_01400 1490651 1491283 - hypothetical protein gene gene1399 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01400 VSVS12_01401 VSVS12_01401 VSVS12_01401 1491574 1493103 + Diguanylate cyclase Contains 1 EAL domain%3B Contains 1 GGDEF domain%3B Contains 1 MHYT domain%3B KEGG: wol:WD0221 two-component system%2C cell cycle response regulator gene gene1400 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01401 VSVS12_01402 VSVS12_01402 VSVS12_01402 1493200 1493730 + hypothetical protein gene gene1401 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01402 VSVS12_01403 VSVS12_01403 VSVS12_01403 1493811 1494263 - hypothetical protein gene gene1402 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01403 VSVS12_01404 VSVS12_01404 VSVS12_01404 1494413 1496326 - hypothetical protein gene gene1403 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01404 VSVS12_01405 VSVS12_01405 VSVS12_01405 1496371 1496760 - hypothetical protein gene gene1404 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01405 VSVS12_01406 VSVS12_01406 VSVS12_01406 1496858 1498183 + hypothetical protein gene gene1405 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01406 VSVS12_01407 VSVS12_01407 hrpA hrpA 1498346 1502275 + RNA helicase Not yet known. Belongs to the DEAD box helicase family. DEAH subfamily%3B Contains 1 helicase ATP-binding domain%3B Contains 1 helicase C-terminal domain%3B KEGG: vcy:IX92_05290 ATP-dependent helicase HrpA gene gene1406 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01407 VSVS12_01408 VSVS12_01408 VSVS12_01408 1502454 1502948 + hypothetical protein gene gene1407 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01408 VSVS12_01409 VSVS12_01409 VSVS12_01409 1503094 1503630 + hypothetical protein gene gene1408 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01409 VSVS12_01410 VSVS12_01410 VSVS12_01410 1503695 1504951 - C4-dicarboxylate transport protein Responsible for the transport of dicarboxylates such as succinate%2C fumarate%2C and malate from the periplasm across the membrane%3B Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2. A. 23) family gene gene1409 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01410 VSVS12_01411 VSVS12_01411 trpA trpA 1505382 1506188 - Tryptophan synthase The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate%3B Belongs to the TrpA family%3B KEGG: eco:b1260 tryptophan synthase alpha chain%3B overlaps another CDS with the same product name gene gene1410 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01411 VSVS12_01412 VSVS12_01412 trpB trpB 1506188 1507378 - Tryptophan synthase The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine%3B Belongs to the TrpB family%3B KEGG: yru:BD65_282 tryptophan synthase beta chain%3B overlaps another CDS with the same product name gene gene1411 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01412 VSVS12_01413 VSVS12_01413 VSVS12_01413 1507390 1508817 - Indole-3-glycerol-phosphate synthase Bifunctional enzyme that catalyzes two sequential steps of tryptophan biosynthetic pathway. The first reaction is catalyzed by the isomerase%2C coded by the TrpF domai%3B the second reaction is catalyzed by the synthase%2C coded by the TrpC domain (By similarity)%3B In the N-terminal sectio%3B belongs to the TrpC family%3B In the C-terminal sectio%3B belongs to the TrpF family%3B KEGG: vha:VIBHAR_02761 indole-3-glycerol phosphate synthase / phosphoribosylanthranilate isomerase gene gene1412 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01413 VSVS12_01414 VSVS12_01414 trpD trpD 1508831 1509829 - Anthranilate phosphoribosyltransferase Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)%3B Belongs to the anthranilate phosphoribosyltransferase family%3B KEGG: pct:PC1_2005 anthranilate phosphoribosyltransferase gene gene1413 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01414 VSVS12_01415 VSVS12_01415 VSVS12_01415 1509841 1510431 - Anthranilate synthase Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate%2C an intermediate in the biosynthesis of L-tryptophan. In the first step%2C the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that%2C along with chorismate%2C is used in the second step%2C catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG%2C TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia. In addition to synthesizing anthranilate%2C it also catalyzes the second step of the pathway%2C the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate%3B In the C-terminal sectio%3B belongs to the anthranilate phosphoribosyltransferase family%3B Contains 1 glutamine amidotransferase type-1 domain%3B KEGG: eco:b1263 anthranilate synthase/phosphoribosyltransferase gene gene1414 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01415 VSVS12_01416 VSVS12_01416 trpE trpE 1510448 1512037 - Anthranilate synthase Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate%2C an intermediate in the biosynthesis of L-tryptophan. In the first step%2C the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that%2C along with chorismate%2C is used in the second step%2C catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG%2C TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia (By similarity)%3B Belongs to the anthranilate synthase component I family%3B KEGG: vch:VC1174 anthranilate synthase component I gene gene1415 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01416 VSVS12_01417 VSVS12_01417 VSVS12_01417 1512594 1513460 + 5'-3' exoribonuclease Efficiently catalyzes the hydrolysis of the 3'-phosphate from 3'%2C5'-bis-phosphonucleotides as well as the successive hydrolysis of 5'-phosphomononucleotides from the 5'-end of short pieces of RNA and DNA%2C with no specificity toward the identity of the nucleotide base. Is more efficient at hydrolyzing RNA oligonucleotides than DNA oligonucleotides. This enzyme can also hydrolyze annealed DNA duplexes%2C albeit at a catalytic efficiency lower than that of the corresponding single-stranded oligonucleotides%3B Belongs to the PHP family. TrpH/YciV subfamily gene gene1416 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01417 VSVS12_01418 VSVS12_01418 VSVS12_01418 1513484 1514104 + L-threonylcarbamoyladenylate synthase Belongs to the SUA5 family%3B Contains 1 YrdC-like domain%3B KEGG: msi:Msm_0612 L-threonylcarbamoyladenylate synthase gene gene1417 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01418 VSVS12_01419 VSVS12_01419 rluB rluB 1514233 1515201 + 23S rRNA pseudouridine(2605) synthase Responsible for synthesis of pseudouridine from uracil- 2605 in 23S ribosomal RNA%3B Belongs to the pseudouridine synthase RsuA family%3B Contains 1 S4 RNA-binding domain%3B KEGG: eco:b1269 23S rRNA pseudouridine2605 synthase gene gene1418 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01419 VSVS12_01420 VSVS12_01420 VSVS12_01420 1515459 1520909 + Ethylene receptor Ethylene receptor related to bacterial two-component regulators. Acts as negative regulator of ethylene signaling. May delay the transition from the vegetative stage to the floral stage by upregulating GI (GIGANTEA) and RCN1 and cause starch accumulation in stems by down-regulating the alpha-amylase AMY3D%3B Belongs to the ethylene receptor family%3B Contains 1 GAF domain%3B Contains 1 histidine kinase domain%3B Contains 1 response regulatory domain gene gene1419 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01420 VSVS12_01421 VSVS12_01421 VSVS12_01421 1520997 1522118 + Hybrid signal transduction histidine kinase Acts as a receptor histidine kinase for a signal transduction pathway. This protein undergoes an ATP-dependent autophosphorylation at a conserved histidine residue in the kinase core%2C and a phosphoryl group is then transferred to a conserved aspartate residue in the receiver domain (By similarity)%3B Contains 2 histidine kinase domains%3B Contains 1 PAC (PAS-associated C-terminal) domain%3B Contains 1 PAS (PER-ARNT-SIM) domain%3B Contains 2 response regulatory domains gene gene1420 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01421 VSVS12_01422 VSVS12_01422 VSVS12_01422 1522120 1523646 + Chemotaxis protein CheY Involved in the transmission of sensory signals from the chemoreceptors to the flagellar motors. CheY is likely to be involved in changing the direction of flagellar rotation. Contains 1 response regulatory domain gene gene1421 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01422 VSVS12_01423 VSVS12_01423 VSVS12_01423 1523691 1524035 - hypothetical protein gene gene1422 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01423 VSVS12_01424 VSVS12_01424 VSVS12_01424 1524070 1524627 - hypothetical protein gene gene1423 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01424 VSVS12_01425 VSVS12_01425 VSVS12_01425 1524858 1525361 - Peptide deformylase Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions%3B Belongs to the polypeptide deformylase family%3B KEGG: xbo:XBJ1_3499 peptide deformylase gene gene1424 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01425 VSVS12_01426 VSVS12_01426 VSVS12_01426 1525569 1526240 - hypothetical protein gene gene1425 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01426 VSVS12_01427 VSVS12_01427 VSVS12_01427 1526388 1526888 - hypothetical protein gene gene1426 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01427 VSVS12_01428 VSVS12_01428 VSVS12_01428 1527101 1528294 + Transposase for insertion sequence element IS1001 Involved in the transposition of the insertion sequence. Belongs to the transposase 12 family gene gene1427 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01428 VSVS12_01429 VSVS12_01429 VSVS12_01429 1528369 1529985 - uncharacterized protein gene gene1428 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01429 VSVS12_01430 VSVS12_01430 VSVS12_01430 1530228 1530551 + Ferredoxin-1 Contains 2 4Fe-4S ferredoxin-type domains gene gene1429 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01430 VSVS12_01431 VSVS12_01431 VSVS12_01431 1530678 1531412 - putative tRNA/rRNA methyltransferase Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family gene gene1430 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01431 VSVS12_01432 VSVS12_01432 VSVS12_01432 1531735 1532913 + hypothetical protein gene gene1431 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01432 VSVS12_01433 VSVS12_01433 VSVS12_01433 1533083 1533496 - hypothetical protein gene gene1432 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01433 VSVS12_01434 VSVS12_01434 VSVS12_01434 1533471 1534679 - hypothetical protein gene gene1433 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01434 VSVS12_01435 VSVS12_01435 VSVS12_01435 1534783 1535100 - hypothetical protein gene gene1434 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01435 VSVS12_01436 VSVS12_01436 VSVS12_01436 1535241 1536449 + hypothetical protein gene gene1435 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01436 VSVS12_01437 VSVS12_01437 VSVS12_01437 1536788 1537276 - hypothetical protein gene gene1436 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01437 VSVS12_01438 VSVS12_01438 VSVS12_01438 1537501 1538373 + Dihydrolipoyllysine-residue acetyltransferase Catalyzes hydrolytic cleavage of carbon-halogen bonds in halogenated aliphatic compounds%2C leading to the formation of the corresponding primary alcohols%2C halide ions and protons. Has a broad substrate specificity%2C which includes mono- and di- chlorinated and brominated alkanes. The highest activity was found with 1%2C2-dibromoethane%2C whereas low activity was measured with the analog 1%2C2-dichloroethane. Belongs to the haloalkane dehalogenase family. Type 2 subfamily%3B KEGG: pbc:CD58_13995 pyruvate dehydrogenase E2 component (dihydrolipoamide acetyltransferase) gene gene1437 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01438 VSVS12_01439 VSVS12_01439 VSVS12_01439 1538639 1539640 - hypothetical protein gene gene1438 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01439 VSVS12_01440 VSVS12_01440 VSVS12_01440 1539953 1540291 + hypothetical protein gene gene1439 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01440 VSVS12_01441 VSVS12_01441 VSVS12_01441 1540331 1541203 + putative NTE family protein Belongs to the NTE family%3B Contains 1 patatin domain gene gene1440 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01441 VSVS12_01442 VSVS12_01442 VSVS12_01442 1541238 1541594 + hypothetical protein gene gene1441 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01442 VSVS12_01443 VSVS12_01443 VSVS12_01443 1541767 1543275 - hypothetical protein gene gene1442 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01443 VSVS12_01444 VSVS12_01444 VSVS12_01444 1544036 1546444 + Beta-mannosidase Exoglycosidase that cleaves the single beta-linked mannose residue from the non-reducing end of beta-mannosidic oligosaccharides of various complexity and length. Prefers manobiose over mannotriose and has no activity against polymeric mannan. Is also severly restricetd by galactosyl substitutions at the +1 subsite (By similarity)%3B Belongs to the glycosyl hydrolase 2 family. Beta- mannosidase B subfamily%3B KEGG: vvu:VV2_1361 beta-mannosidase gene gene1443 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01444 VSVS12_01445 VSVS12_01445 VSVS12_01445 1546591 1547472 - hypothetical protein gene gene1444 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01445 VSVS12_01446 VSVS12_01446 VSVS12_01446 1547557 1548432 - hypothetical protein gene gene1445 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01446 VSVS12_01447 VSVS12_01447 VSVS12_01447 1548487 1550220 - E3 ubiquitin-protein ligase SlrP Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein is an E3 ubiquitin ligase that interferes with host's ubiquitination pathway. Can ubiquitinate both ubiquitin and host TXN (Thioredoxin). Leads to significant decrease of thioredoxin activity and increase of host cell death (By similarity)%3B Belongs to the LRR-containing bacterial E3 ligase family%3B Contains 10 LRR (leucine-rich) repeats gene gene1446 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01447 VSVS12_01448 VSVS12_01448 VSVS12_01448 1550533 1551315 + Ribonuclease H Endonuclease that specifically degrades the RNA of RNA- DNA hybrids%3B Belongs to the RNase H family%3B Contains 1 RNase H domain%3B KEGG: slo:Shew_1682 ribonuclease HI gene gene1447 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01448 VSVS12_01449 VSVS12_01449 VSVS12_01449 1551396 1552340 - hypothetical protein gene gene1448 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01449 VSVS12_01450 VSVS12_01450 VSVS12_01450 1552564 1553070 + hypothetical protein gene gene1449 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01450 VSVS12_01451 VSVS12_01451 VSVS12_01451 1553091 1554299 + hypothetical protein gene gene1450 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01451 VSVS12_01452 VSVS12_01452 VSVS12_01452 1554339 1554572 + hypothetical protein gene gene1451 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01452 VSVS12_01453 VSVS12_01453 VSVS12_01453 1554582 1555790 - hypothetical protein gene gene1452 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01453 VSVS12_01454 VSVS12_01454 VSVS12_01454 1555914 1556996 + hypothetical protein gene gene1453 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01454 VSVS12_01455 VSVS12_01455 rsuA rsuA 1557267 1557962 + 16S rRNA pseudouridine(516) synthase Responsible for synthesis of pseudouridine from uracil- 516 in 16S ribosomal RNA%3B Belongs to the pseudouridine synthase RsuA family%3B Contains 1 S4 RNA-binding domain%3B KEGG: vch:VC1635 16S rRNA pseudouridine516 synthase gene gene1454 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01455 VSVS12_01456 VSVS12_01456 murQ murQ 1558246 1559145 + N-acetylmuramic acid 6-phosphate etherase Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate%2C producing GlcNAc 6- phosphate and D-lactate. Together with AnmK%2C is also required for the utilization of anhydro-N-acetylmuramic acid (anhMurNAc) either imported from the medium or derived from its own cell wall murein%2C and thus plays a role in cell wall recycling%3B Belongs to the GCKR-like family. MurNAc-6-P etherase subfamily%3B Contains 1 SIS domain%3B KEGG: vej:VEJY3_01755 N-acetylmuramic acid 6-phosphate etherase gene gene1455 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01456 VSVS12_01457 VSVS12_01457 scrA scrA 1559150 1560505 + Protein-N(pi)-phosphohistidine--sugar phosphotransferase The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS)%2C a major carbohydrate active -transport system%2C catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in beta-glucoside transport (By similarity)%3B Contains 1 PTS EIIA type-1 domain%3B Contains 1 PTS EIIB type-1 domain%3B Contains 1 PTS EIIC type-1 domain%3B KEGG: pmr:PMI3515 PTS system%2C sucrose-specific IIB component gene gene1456 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01457 VSVS12_01458 VSVS12_01458 VSVS12_01458 1560608 1561459 + HTH-type transcriptional regulator MurR Represses the expression of the murPQ operon involved in the uptake and degradation of N-acetylmuramic acid (MurNAc). Binds to two adjacent inverted repeats within the operator region. MurNAc 6-phosphate%2C the substrate of MurQ%2C is the specific inducer that weakens binding of MurR to the operator%3B Contains 1 HTH rpiR-type DNA-binding domain%3B Contains 1 SIS domain gene gene1457 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01458 VSVS12_01459 VSVS12_01459 VSVS12_01459 1561463 1561801 + Inner membrane protein To M. tuberculosis Rv2272 gene gene1458 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01459 VSVS12_01460 VSVS12_01460 VSVS12_01460 1561798 1562112 + hypothetical protein gene gene1459 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01460 VSVS12_01461 VSVS12_01461 VSVS12_01461 1562184 1562444 - hypothetical protein gene gene1460 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01461 VSVS12_01462 VSVS12_01462 VSVS12_01462 1562899 1563915 + Lactocepin KEGG: pta:HPL003_05920 lactocepin gene gene1461 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01462 VSVS12_01463 VSVS12_01463 VSVS12_01463 1564057 1564701 - hypothetical protein gene gene1462 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01463 VSVS12_01464 VSVS12_01464 VSVS12_01464 1564997 1566205 + hypothetical protein gene gene1463 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01464 VSVS12_01465 VSVS12_01465 VSVS12_01465 1566363 1568318 + Putative alkyl/aryl-sulfatase YjcS Belongs to the metallo-beta-lactamase superfamily%3B KEGG: vfi:VF_A0035 uncharacterized sulfatase%3B Sulfuric ester hydrolases gene gene1464 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01465 VSVS12_01466 VSVS12_01466 VSVS12_01466 1568365 1568862 + hypothetical protein gene gene1465 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01466 VSVS12_01467 VSVS12_01467 VSVS12_01467 1569031 1569375 - uncharacterized protein Contains 1 HNH domain gene gene1466 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01467 VSVS12_01468 VSVS12_01468 VSVS12_01468 1569436 1569579 - hypothetical protein gene gene1467 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01468 VSVS12_01469 VSVS12_01469 VSVS12_01469 1569632 1570594 - putative deferrochelatase/peroxidase YfeX Involved in the recovery of exogenous heme iron. Extracts iron from heme while preserving the tetrapyrrol ring intact%3B Belongs to the DyP-type peroxidase family gene gene1468 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01469 VSVS12_01470 VSVS12_01470 VSVS12_01470 1570860 1572122 - hypothetical protein gene gene1469 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01470 VSVS12_01471 VSVS12_01471 VSVS12_01471 1572224 1573156 - Carboxylesterase NlhH Hydrolyzes various short-chain esters%2C such as triacylglycerols and vinyl esters. Has no activity against emulsified substrates (By similarity)%3B Belongs to the 'GDXG' lipolytic enzyme family%3B KEGG: myv:G155_04140 acetyl esterase%3B Carboxylic ester hydrolases gene gene1470 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01471 VSVS12_01472 VSVS12_01472 VSVS12_01472 1573166 1574368 - uncharacterized protein gene gene1471 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01472 VSVS12_01473 VSVS12_01473 fabV fabV 1574568 1575770 - Enoyl-[acyl-carrier-protein] reductase (NADH) Involved in the final reduction of the elongation cycle of fatty acid synthesis (FAS II). Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP)%3B Belongs to the TER reductase family%3B KEGG: vvu:VV2_0265 enoyl-(acyl-carrier protein) reductase / trans-2-enoyl-CoA reductase (NAD+) gene gene1472 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01473 VSVS12_01474 VSVS12_01474 VSVS12_01474 1575792 1576208 - Phosphate acetyltransferase Catalyzes the hydration of trans-2-enoyl-CoAs with a chain-length of 4-6 carbon atoms%2C forming the corresponding (3R)- 3-hydroxyacyl-CoAs%2C which can then be utilized for the production of polyhydroxyalkanoates (PHA) polymers. Cannot use trans-2%2C3- octenoyl-CoA as substrate%3B Contains 1 MaoC-like domain%3B KEGG: rhd:R2APBS1_2145 phosphate acetyltransferase gene gene1473 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01474 VSVS12_01475 VSVS12_01475 VSVS12_01475 1576324 1577943 - Propionate CoA-transferase CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons. Exhibits high activity with acetoacetyl-CoA%2C propionyl-CoA%2C crotonoyl-CoA or butyryl-CoA as donors%2C with acetate as an acceptor. When acetyl-CoA is used as the donor%2C propionate%2C acetoacetate%2C butyrate%2C isobutyrate%2C and 4-hydroxybutyrate can be utilized as acceptors but not isovalerate. May play a role in short-chain fatty acid metabolism in E. coli%3B Belongs to the 3-oxoacid CoA-transferase family%3B KEGG: app:CAP2UW1_0217 propionate CoA-transferase gene gene1474 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01475 VSVS12_01476 VSVS12_01476 VSVS12_01476 1578129 1579037 - HTH-type transcriptional activator TtdR Positive regulator required for L-tartrate-dependent anaerobic growth on glycerol. Induces expression of the ttdA-ttdB- ygjE operon (By similarity)%3B Contains 1 HTH lysR-type DNA-binding domain gene gene1475 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01476 VSVS12_01477 VSVS12_01477 VSVS12_01477 1579355 1580089 + 3-oxoacyl-[acyl-carrier-protein] reductase Belongs to the short-chain dehydrogenases/reductases (SDR) family%3B KEGG: hap:HAPS_0854 3-oxoacyl-(acyl-carrier protein) reductase gene gene1476 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01477 VSVS12_01478 VSVS12_01478 atoB atoB 1580100 1581305 + Acetyl-CoA C-acetyltransferase Plays a role in ketone body metabolism (By similarity). Has an effect on lysosome related organelles (LRO) function%2C in a pathway with serotonin (PubMed:24204312). Acts downstream of sir- 2. 1 to regulate aging and stress resistance (PubMed:20956318)%3B Belongs to the thiolase family%3B KEGG: vch:VCA0690 acetyl-CoA C-acetyltransferase gene gene1477 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01478 VSVS12_01479 VSVS12_01479 VSVS12_01479 1581419 1582318 - DnaJ like protein subfamily C member 24 Stimulates the ATPase activity of several Hsp70-type chaperones. This ability is enhanced by iron-binding. The iron- bound form is redox-active and can function as electron carrier. Plays a role in the diphthamide biosynthesis%2C a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2) (By similarity)%3B Belongs to the DPH4 family%3B Contains 1 DPH-type zinc finger%3B Contains 1 J domain gene gene1478 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01479 VSVS12_01480 VSVS12_01480 VSVS12_01480 1582449 1584344 - Chaperone protein DnaK Acts as a chaperone%3B Belongs to the heat shock protein 70 family gene gene1479 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01480 VSVS12_01481 VSVS12_01481 VSVS12_01481 1584637 1585056 - Small heat shock protein IbpA Associates with aggregated proteins%2C together with IbpB%2C to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress. Aggregated proteins bound to the IbpAB complex are more efficiently refolded and reactivated by the ATP-dependent chaperone systems ClpB and DnaK/DnaJ/GrpE. Its activity is ATP- independent%3B Belongs to the small heat shock protein (HSP20) family gene gene1480 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01481 VSVS12_01482 VSVS12_01482 VSVS12_01482 1585656 1587038 + GTPase HflX GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis%3B Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family%3B Contains 1 Hflx-type G (guanine nucleotide-binding) domain gene gene1481 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01482 VSVS12_01483 VSVS12_01483 VSVS12_01483 1587106 1590168 - Multidrug resistance protein MdtB The MdtABC tripartite complex confers resistance against novobiocin and deoxycholate%3B Belongs to the resistance-nodulation-cell division (RND) (TC 2. A. 6) family. MdtB subfamily gene gene1482 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01483 VSVS12_01484 VSVS12_01484 VSVS12_01484 1590202 1591260 - Antibiotic efflux pump periplasmic linker protein ArpA The periplasmic linker protein component of an antibiotic efflux pump. Confers resistance to numerous structurally unrelated antibiotics such as carbenicillin%2C chloramphenicol%2C erythromycin%2C novobiocin%2C streptomycin and tetracycline. Is not involved in organic solvent efflux. Belongs to the membrane fusion protein (MFP) (TC 8. A. 1) family gene gene1483 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01484 VSVS12_01485 VSVS12_01485 VSVS12_01485 1591700 1592947 + Putative permease Belongs to the UPF0718 family gene gene1484 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01485 VSVS12_01486 VSVS12_01486 hdhA hdhA 1593008 1593853 + 7-alpha-hydroxysteroid dehydrogenase Belongs to the short-chain dehydrogenases/reductases (SDR) family%3B KEGG: prw:PsycPRwf_0646 7-alpha-hydroxysteroid dehydrogenase gene gene1485 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01486 VSVS12_01487 VSVS12_01487 VSVS12_01487 1593906 1595237 - Transposase InsG for insertion sequence element IS4 Involved in the transposition of the insertion sequence IS4. Belongs to the transposase 11 family gene gene1486 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01487 VSVS12_01488 VSVS12_01488 VSVS12_01488 1595387 1597696 - hypothetical protein gene gene1487 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01488 VSVS12_01489 VSVS12_01489 mtnN mtnN 1598050 1598802 + Adenosylhomocysteine nucleosidase Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose%2C 5'-methylthioribose and S-ribosylhomocysteine%2C respectively%3B Belongs to the PNP/UDP phosphorylase family. MtnN subfamily%3B KEGG: vpa:VPA1089 adenosylhomocysteine nucleosidase gene gene1488 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01489 VSVS12_01490 VSVS12_01490 VSVS12_01490 1598881 1600623 - hypothetical protein gene gene1489 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01490 VSVS12_01491 VSVS12_01491 fdoG fdoG 1600850 1605181 - Formate dehydrogenase Contains 4 4Fe-4S ferredoxin-type domains%3B KEGG: vvu:VV2_1360 formate dehydrogenase major subunit gene gene1490 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01491 VSVS12_01492 VSVS12_01492 VSVS12_01492 1605477 1606085 - Ribosomal-protein-alanine N-acetyltransferase Contains 1 N-acetyltransferase domain%3B KEGG: pbc:CD58_16375 ribosomal-protein-alanine N-acetyltransferase gene gene1491 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01492 VSVS12_01493 VSVS12_01493 VSVS12_01493 1606186 1607031 - hypothetical protein gene gene1492 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01493 VSVS12_01494 VSVS12_01494 VSVS12_01494 1607260 1607604 + hypothetical protein gene gene1493 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01494 VSVS12_01495 VSVS12_01495 VSVS12_01495 1607781 1608683 + Regulatory protein Transcriptional activator of the superoxide response regulon of E. coli that includes at least 10 genes such as sodA%2C nfo%2C zwf and micF. Binds the DNA sequence 5'-GCACN(7)CAA-3'. It also facilitates the subsequent binding of RNA polymerase to the micF and the nfo promoters (By similarity)%3B Contains 1 HTH araC/xylS-type DNA-binding domain gene gene1494 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01495 VSVS12_01496 VSVS12_01496 amiE amiE 1608941 1610521 + Amidase Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)%3B Belongs to the amidase family. GatA subfamily%3B KEGG: mxa:MXAN_6372 amidase gene gene1495 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01496 VSVS12_01497 VSVS12_01497 VSVS12_01497 1610578 1611576 + hypothetical protein gene gene1496 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01497 VSVS12_01498 VSVS12_01498 VSVS12_01498 1611857 1612873 + Ornithine utilization regulator Probably activates the ArgJ gene that encodes ornithine acetyltransferase. Binds to its own promoter-operator region. Probably binds ornithine. Contains 1 HTH araC/xylS-type DNA-binding domain gene gene1497 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01498 VSVS12_01499 VSVS12_01499 VSVS12_01499 1613075 1616413 - Chitinase Hydrolyzes chitin oligosaccharide%3B (GlcNAc)4 to (GlcNAc)2 and (GlcNAc)5%2C6 to (GlcNAc)2 and (GlcNAc)3. Inactive towards chitin%2C glucosamine oligosaccharides%2C glycoproteins and glycopeptides containing (GlcNAc)2. Belongs to the glycosyl hydrolase 18 family%3B KEGG: vvu:VV2_0213 chitinase gene gene1498 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01499 VSVS12_01500 VSVS12_01500 VSVS12_01500 1617203 1617988 + dTDP-3-amino-3%2C4%2C6-trideoxy-alpha-D-glucopyranose S-adenosyl-L-methionine-dependent methyltransferase involved in the biosynthesis of desosamine%2C found in certain macrolide antibiotics such as erthyromycin%2C azithromycin%2C and clarithromycin. Catalyzes the last step in the biosynthesis of dTDP-desosamine%3B Belongs to the methyltransferase TylM1/DesVI family gene gene1499 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01500 VSVS12_01501 VSVS12_01501 VSVS12_01501 1618240 1619124 + hypothetical protein gene gene1500 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01501 VSVS12_01502 VSVS12_01502 VSVS12_01502 1619767 1621584 + hypothetical protein gene gene1501 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01502 VSVS12_01503 VSVS12_01503 VSVS12_01503 1621907 1623238 - hypothetical protein gene gene1502 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01503 VSVS12_01504 VSVS12_01504 VSVS12_01504 1624380 1624586 + hypothetical protein gene gene1503 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01504 VSVS12_01505 VSVS12_01505 VSVS12_01505 1624771 1625715 - Protein AdrA Contains 1 GGDEF domain gene gene1504 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01505 VSVS12_01506 VSVS12_01506 VSVS12_01506 1626079 1626702 + hypothetical protein gene gene1505 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01506 VSVS12_01507 VSVS12_01507 VSVS12_01507 1626811 1627845 + hypothetical protein gene gene1506 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01507 VSVS12_01508 VSVS12_01508 VSVS12_01508 1627845 1629365 + hypothetical protein gene gene1507 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01508 VSVS12_01509 VSVS12_01509 VSVS12_01509 1629372 1630559 + hypothetical protein gene gene1508 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01509 VSVS12_01510 VSVS12_01510 VSVS12_01510 1630563 1631456 + hypothetical protein gene gene1509 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01510 VSVS12_01511 VSVS12_01511 VSVS12_01511 1631402 1632220 + hypothetical protein gene gene1510 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01511 VSVS12_01512 VSVS12_01512 VSVS12_01512 1632230 1632823 + hypothetical protein gene gene1511 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01512 VSVS12_01513 VSVS12_01513 VSVS12_01513 1632842 1633963 + Endo-type membrane-bound lytic murein transglycosylase A-like protein Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division (Potential)%3B Belongs to the transglycosylase Slt family gene gene1512 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01513 VSVS12_01514 VSVS12_01514 VSVS12_01514 1633947 1634912 + hypothetical protein gene gene1513 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01514 VSVS12_01515 VSVS12_01515 VSVS12_01515 1635011 1636669 - CoA-disulfide reductase Catalyzes specifically the NADPH-dependent reduction of coenzyme A disulfide%3B Belongs to the class-III pyridine nucleotide-disulfide oxidoreductase family%3B KEGG: sau:SA0831 CoA-disulfide reductase gene gene1514 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01515 VSVS12_01516 VSVS12_01516 VSVS12_01516 1636944 1638362 + Internalin-J Involved in several steps of L. monocytogenes infection%3B Contains 14 LRR (leucine-rich) repeats%3B Contains 4 MucBP domains gene gene1515 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01516 VSVS12_01517 VSVS12_01517 VSVS12_01517 1638511 1639218 + hypothetical protein gene gene1516 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01517 VSVS12_01518 VSVS12_01518 VSVS12_01518 1639289 1648846 - hypothetical protein gene gene1517 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01518 VSVS12_01519 VSVS12_01519 VSVS12_01519 1649173 1649388 - hypothetical protein gene gene1518 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01519 VSVS12_01520 VSVS12_01520 VSVS12_01520 1649683 1651308 + Methyl-accepting chemotaxis protein II Receptor for the attractant L-aspartate and related amino and dicarboxylic acids. Tar mediates taxis away from the repellents cobalt and nickel. Unlike in E. coli tar%2C it does not mediates maltose taxis. Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment%2C transduce a signal from the outside to the inside of the cell%2C and facilitate sensory adaptation through the variation of the level of methylation. Attractants increase the level of methylation while repellents decrease the level of methylation%2C the methyl groups are added by the methyltransferase CheR and removed by the methylesterase CheB. Contains 1 HAMP domain%3B Contains 1 methyl-accepting transducer domain gene gene1519 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01520 VSVS12_01521 VSVS12_01521 VSVS12_01521 1651770 1654115 + Chitinase Degrades chitin%2C chitotriose and chitobiose. May participate in the defense against nematodes and other pathogens. Isoform 3 has no enzymatic activity%3B Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily%3B Contains 1 chitin-binding type-2 domain%3B KEGG: pgb:H744_1c1215 chitinase gene gene1520 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01521 VSVS12_01522 VSVS12_01522 VSVS12_01522 1654304 1654555 + hypothetical protein gene gene1521 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01522 VSVS12_01523 VSVS12_01523 VSVS12_01523 1654652 1655551 - Solute carrier family 35 member G1 May play a role in intracellular calcium sensing and homeostasis. May act as a negative regulator of plasma membrane calcium-transporting ATPases preventing calcium efflux from the cell%3B Belongs to the TMEM20 family%3B Contains 2 EamA domains gene gene1522 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01523 VSVS12_01524 VSVS12_01524 VSVS12_01524 1655981 1657906 + hypothetical protein gene gene1523 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01524 VSVS12_01525 VSVS12_01525 VSVS12_01525 1658156 1658962 + hypothetical protein gene gene1524 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01525 VSVS12_01526 VSVS12_01526 VSVS12_01526 1659073 1659357 - Carboxypeptidase Taq KEGG: ype:YPO2310 carboxypeptidase Taq gene gene1525 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01526 VSVS12_01527 VSVS12_01527 VSVS12_01527 1660253 1661557 - 6-aminohexanoate-oligomer exohydrolase KEGG: ban:BA_3346 6-aminohexanoate-oligomer exohydrolase gene gene1526 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01527 VSVS12_01528 VSVS12_01528 VSVS12_01528 1661697 1662596 + hypothetical protein gene gene1527 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01528 VSVS12_01529 VSVS12_01529 VSVS12_01529 1662872 1664353 - Carboxypeptidase Taq Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus%2C including neutral%2C aromatic%2C polar and basic residues%2C but not Pro%3B Belongs to the peptidase M32 family%3B KEGG: enl:A3UG_09990 carboxypeptidase Taq gene gene1528 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01529 VSVS12_01530 VSVS12_01530 VSVS12_01530 1664548 1665177 + Homoserine/homoserine lactone efflux protein Conducts the efflux of homoserine and homoserine lactone%3B Belongs to the rht family gene gene1529 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01530 VSVS12_01531 VSVS12_01531 VSVS12_01531 1665312 1666682 - Sodium/alanine symporter AgcS Probably functions as a sodium/L- and D-alanine symporter for alanine uptake%3B Belongs to the sodium:alanine (SAF) symporter family gene gene1530 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01531 VSVS12_01532 VSVS12_01532 VSVS12_01532 1667351 1667692 - hypothetical protein gene gene1531 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01532 VSVS12_01533 VSVS12_01533 VSVS12_01533 1667921 1668079 + hypothetical protein gene gene1532 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01533 VSVS12_01534 VSVS12_01534 VSVS12_01534 1668097 1668837 + hypothetical protein gene gene1533 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01534 VSVS12_01535 VSVS12_01535 VSVS12_01535 1668938 1669483 - hypothetical protein gene gene1534 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01535 VSVS12_01536 VSVS12_01536 VSVS12_01536 1669666 1670163 - hypothetical protein gene gene1535 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01536 VSVS12_01537 VSVS12_01537 VSVS12_01537 1670182 1672110 - Non-specific serine/threonine protein kinase KEGG: ana:all3691 protein kinase gene gene1536 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01537 VSVS12_01538 VSVS12_01538 VSVS12_01538 1672341 1673609 + hypothetical protein gene gene1537 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01538 VSVS12_01539 VSVS12_01539 serC serC 1673751 1674833 + Phosphoserine transaminase Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine%3B Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily%3B KEGG: eco:b0907 phosphoserine aminotransferase gene gene1538 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01539 VSVS12_01540 VSVS12_01540 thg1 thg1 1674943 1677351 - tRNA(His) guanylyltransferase Belongs to the UPF0313 family%3B KEGG: cic:CICLE_v10027573mg tRNA(His) guanylyltransferase gene gene1539 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01540 VSVS12_01541 VSVS12_01541 VSVS12_01541 1677580 1684470 + hypothetical protein gene gene1540 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01541 VSVS12_01542 VSVS12_01542 VSVS12_01542 1684618 1685322 + hypothetical protein gene gene1541 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01542 VSVS12_01543 VSVS12_01543 VSVS12_01543 1685449 1685649 + hypothetical protein gene gene1542 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01543 VSVS12_01544 VSVS12_01544 VSVS12_01544 1685736 1686647 - HTH-type transcriptional regulator MetR Control of the last step in methionine biosynthesi%3B MetR is a positive activator of the metA%2C metE and metH genes%3B Contains 1 HTH lysR-type DNA-binding domain gene gene1543 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01544 VSVS12_01545 VSVS12_01545 metE metE 1686935 1689217 + 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation%3B Belongs to the vitamin-B12 independent methionine synthase family%3B KEGG: vvu:VV1_2219 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase gene gene1544 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01545 VSVS12_01546 VSVS12_01546 VSVS12_01546 1689304 1691022 - Putative transport protein Belongs to the AAE transporter (TC 2. A. 81) family. YbjL subfamily%3B Contains 2 RCK C-terminal domains gene gene1545 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01546 VSVS12_01547 VSVS12_01547 VSVS12_01547 1691196 1691462 - Glutaredoxin Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins (By similarity)%3B Belongs to the glutaredoxin family%3B Contains 1 glutaredoxin domain gene gene1546 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01547 VSVS12_01548 VSVS12_01548 VSVS12_01548 1691712 1692965 + putative alcohol dehydrogenase Belongs to the iron-containing alcohol dehydrogenase family%3B KEGG: ppr:PBPRA2418 null%3B With NAD(+) or NADP(+) as acceptor gene gene1547 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01548 VSVS12_01549 VSVS12_01549 VSVS12_01549 1693051 1693905 - HTH-type transcriptional regulator HexR Represses the expression of the hex regulon (zwf%2C eda%2C glp and gap)%3B Contains 1 HTH rpiR-type DNA-binding domain%3B Contains 1 SIS domain gene gene1548 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01549 VSVS12_01550 VSVS12_01550 gadB gadB 1694197 1695819 - Glutamate decarboxylase May catalyze the decarboxylation of aspartate%2C cysteine sulfinic acid%2C and cysteic acid to beta-alanine%2C hypotaurine and taurine%2C respectively. Does not exhibit any decarboxylation activity toward glutamate%3B Belongs to the group II decarboxylase family%3B KEGG: vvu:VV1_2824 glutamate decarboxylase gene gene1549 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01550 VSVS12_01551 VSVS12_01551 VSVS12_01551 1696039 1696551 - hypothetical protein gene gene1550 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01551 VSVS12_01552 VSVS12_01552 VSVS12_01552 1696639 1697544 - Lysine exporter LysO Mediates export of lysine%3B Belongs to the LysO family gene gene1551 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01552 VSVS12_01553 VSVS12_01553 VSVS12_01553 1697561 1698481 - hypothetical protein gene gene1552 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01553 VSVS12_01554 VSVS12_01554 VSVS12_01554 1698851 1698955 + hypothetical protein gene gene1553 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01554 VSVS12_01555 VSVS12_01555 VSVS12_01555 1698965 1700173 - hypothetical protein gene gene1554 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01555 VSVS12_01556 VSVS12_01556 VSVS12_01556 1700285 1700770 + DNA transformation protein TfoX1 Required for DNA transformation jointly with TfoX2%3B Belongs to the TfoX family gene gene1555 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01556 VSVS12_01557 VSVS12_01557 VSVS12_01557 1700883 1701272 + hypothetical protein gene gene1556 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01557 VSVS12_01558 VSVS12_01558 VSVS12_01558 1701447 1701875 + hypothetical protein gene gene1557 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01558 VSVS12_01559 VSVS12_01559 VSVS12_01559 1701971 1702462 - hypothetical protein gene gene1558 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01559 VSVS12_01560 VSVS12_01560 VSVS12_01560 1702473 1705622 - Cation efflux system protein CusA Part of a cation efflux system that mediates resistance to copper and silver%3B Belongs to the resistance-nodulation-cell division (RND) (TC 2. A. 6) family gene gene1559 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01560 VSVS12_01561 VSVS12_01561 VSVS12_01561 1705619 1707349 - Putative membrane fusion protein SilB Component of the sil cation efflux system that confers resistance to silver. May be part of a three-component cation/proton antiporter. Belongs to the membrane fusion protein (MFP) (TC 8. A. 1) family gene gene1560 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01561 VSVS12_01562 VSVS12_01562 VSVS12_01562 1707360 1708775 - hypothetical protein gene gene1561 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01562 VSVS12_01563 VSVS12_01563 VSVS12_01563 1708883 1709281 - hypothetical protein gene gene1562 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01563 VSVS12_01564 VSVS12_01564 pepT pepT 1709414 1710520 - Tripeptide aminopeptidase Could be a peptidase. Belongs to the peptidase M20A family%3B KEGG: vfi:VF_A0004 tripeptide aminopeptidase gene gene1563 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01564 VSVS12_01565 VSVS12_01565 hppD hppD 1710850 1711923 + 4-hydroxyphenylpyruvate dioxygenase Belongs to the 4HPPD family%3B KEGG: ppr:PBPRB1180 4-hydroxyphenylpyruvate dioxygenase gene gene1564 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01565 VSVS12_01566 VSVS12_01566 hmgA hmgA 1711916 1713046 + Homogentisate 1%2C2-dioxygenase Belongs to the homogentisate dioxygenase family%3B KEGG: vch:VC1345 homogentisate 1%2C2-dioxygenase gene gene1565 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01566 VSVS12_01567 VSVS12_01567 faaH faaH 1713074 1714081 + Fumarylacetoacetase KEGG: vch:VC1346 fumarylacetoacetate (FAA) hydrolase gene gene1566 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01567 VSVS12_01568 VSVS12_01568 nagL nagL 1714081 1714731 + Maleylpyruvate isomerase Belongs to the GST superfamily. Zeta family%3B Contains 1 GST C-terminal domain%3B Contains 1 GST N-terminal domain%3B KEGG: dja:HY57_20110 maleylpyruvate isomerase gene gene1567 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01568 VSVS12_01569 VSVS12_01569 VSVS12_01569 1714810 1714995 - hypothetical protein gene gene1568 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01569 VSVS12_01570 VSVS12_01570 VSVS12_01570 1715164 1716204 - Secretory immunoglobulin A-binding protein EsiB Upon host (human neutrophil) infection interferes with productive FCAR signaling%2C inhibiting secreted IgA (SIgA) effector functions and probably avoiding neutrophil activation. Inhibits the SIgA-mediated oxidative burst by neutrophils%2C decreases generation of ROS (reactive oxygen species) by neutrophils and reduces chemotaxis by neutrophils%2C all of which are SIgA effector functions used to stimulate the immune response. Does not block SIgA-binding to its receptor (FCAR) on neutrophils%2C but it decreases SIgA-stimulated phosphorylation of cytoplasmic proteins%2C including phospholipase C-gamma and MAP kinases%2C all actions that may be advantageous to the pathogen%3B Contains 11 Sel1-like repeats gene gene1569 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01570 VSVS12_01571 VSVS12_01571 VSVS12_01571 1716344 1717012 - putative lipoprotein YiaD Suppresses temperature-sensitive mutations in BamB when overexpressed%3B Belongs to the OmpA family%3B Contains 1 OmpA-like domain gene gene1570 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01571 VSVS12_01572 VSVS12_01572 VSVS12_01572 1717177 1717860 - hypothetical protein gene gene1571 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01572 VSVS12_01573 VSVS12_01573 VSVS12_01573 1718062 1718778 - hypothetical protein gene gene1572 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01573 VSVS12_01574 VSVS12_01574 glcD glcD 1719001 1722027 + (S)-2-hydroxy-acid oxidase Contains 1 4Fe-4S ferredoxin-type domain%3B Contains 1 FAD-binding PCMH-type domain%3B To E. coli YdiJ%3B To mammalian alkyldihydroxyacetonephosphate synthases%2C to yeast AIP2 and DLD1 and to E. coli YgcU%3B KEGG: gau:GAU_0600 glycolate oxidase gene gene1573 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01574 VSVS12_01575 VSVS12_01575 icmT icmT 1722027 1722488 + Protein-S-isoprenylcysteine O-methyltransferase KEGG: loa:LOAG_09538 protein-S-isoprenylcysteine O-methyltransferase gene gene1574 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01575 VSVS12_01576 VSVS12_01576 VSVS12_01576 1722566 1723234 - Arginine ABC transporter permease protein Part of the ABC transporter complex ArtPIQMJ involved in arginine transport. Probably responsible for the translocation of the substrate across the membrane (By similarity)%3B Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily%3B Contains 1 ABC transmembrane type-1 domain gene gene1575 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01576 VSVS12_01577 VSVS12_01577 VSVS12_01577 1723231 1723920 - Octopine transport system permease protein OccQ Component of the octopine active transport system probably consisting of four subunits: Q%2C M%2C P and T%3B Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily%3B Contains 1 ABC transmembrane type-1 domain gene gene1576 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01577 VSVS12_01578 VSVS12_01578 VSVS12_01578 1723922 1724653 - Putative ABC transporter arginine-binding protein Part of the ABC transporter complex ArtPIQMJ involved in arginine transport%3B Belongs to the bacterial solute-binding protein 3 family gene gene1577 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01578 VSVS12_01579 VSVS12_01579 artP artP 1724712 1725455 - General L-amino acid transport ATP-binding protein AapP Part of a binding-protein-dependent transport system for L-amino acids%2C affects the uptake as well as the efflux of these amino acids. Probably responsible for energy coupling to the transport system. Belongs to the ABC transporter superfamily%3B Contains 1 ABC transporter domain%3B KEGG: vcm:VCM66_A0719 arginine transport system ATP-binding protein%3B Acting on acid anhydrides%3B catalyzing transmembrane movement of substances gene gene1578 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01579 VSVS12_01580 VSVS12_01580 VSVS12_01580 1725724 1726449 - hypothetical protein gene gene1579 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01580 VSVS12_01581 VSVS12_01581 VSVS12_01581 1726715 1727155 + hypothetical protein gene gene1580 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01581 VSVS12_01582 VSVS12_01582 VSVS12_01582 1727464 1728087 + hypothetical protein gene gene1581 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01582 VSVS12_01583 VSVS12_01583 hutH hutH 1728162 1729694 - Histidine ammonia-lyase Belongs to the PAL/histidase family%3B KEGG: hch:HCH_04172 histidine ammonia-lyase gene gene1582 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01583 VSVS12_01584 VSVS12_01584 hutU hutU 1729697 1731391 - Urocanate hydratase Belongs to the urocanase family%3B KEGG: vch:VC1203 urocanate hydratase gene gene1583 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01584 VSVS12_01585 VSVS12_01585 hutG hutG 1731412 1732410 - Formimidoylglutamase Belongs to the arginase family%3B KEGG: vcy:IX92_06190 formiminoglutamase gene gene1584 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01585 VSVS12_01586 VSVS12_01586 hutI hutI 1732403 1733674 - Imidazolonepropionase Belongs to the HutI family%3B KEGG: sau:SA2121 imidazolonepropionase gene gene1585 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01586 VSVS12_01587 VSVS12_01587 VSVS12_01587 1733777 1734490 - Arabinose metabolism transcriptional repressor Transcriptional repressor of the arabinose utilization genes. Also regulates its own expression. Binds to two sequences within the promoters of the araABDLMNPQ-abfA operon and the araE gene%2C and to one sequence in the araR promoter. Contains 1 HTH gntR-type DNA-binding domain gene gene1586 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01587 VSVS12_01588 VSVS12_01588 VSVS12_01588 1734739 1735482 + Sporulation-control protein spo0M Controls the expression of spo0A and is required to pass the morphological stage 0 of sporulation%3B Belongs to the spo0M family gene gene1587 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01588 VSVS12_01589 VSVS12_01589 VSVS12_01589 1735493 1736467 - hypothetical protein gene gene1588 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01589 VSVS12_01590 VSVS12_01590 VSVS12_01590 1736601 1737377 - hypothetical protein gene gene1589 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01590 VSVS12_01591 VSVS12_01591 tpmT tpmT 1737709 1738356 + Thiopurine S-methyltransferase Belongs to the class I-like SAM-binding methyltransferase superfamily. TPMT family%3B KEGG: vch:VC1226 thiopurine S-methyltransferase gene gene1590 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01591 VSVS12_01592 VSVS12_01592 purT purT 1738433 1739608 - Phosphoribosylglycinamide formyltransferase Catalyzes two reactions: the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate%2C ATP and beta GA%3B the second%2C a side reaction%2C is the production of acetyl phosphate and ADP from acetate and ATP%3B Belongs to the PurK/PurT family%3B Contains 1 ATP-grasp domain%3B KEGG: vch:VC1228 phosphoribosylglycinamide formyltransferase 2 gene gene1591 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01592 VSVS12_01593 VSVS12_01593 VSVS12_01593 1739851 1741269 + putative transporter Belongs to the CitM (TC 2. A. 11) transporter family%3B Contains 1 SPX domain gene gene1592 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01593 VSVS12_01594 VSVS12_01594 VSVS12_01594 1741273 1742595 + C4-dicarboxylate transport sensor protein DctB Member of the two-component regulatory system DctB/DctD involved in the transport of C4-dicarboxylates. DctB functions as a membrane-associated protein kinase that phosphorylates DctD in response to environmental signals. Contains 1 histidine kinase domain%3B KEGG: vfi:VF_1053 null%3B Phosphotransferases with a nitrogenous group as acceptor gene gene1593 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01594 VSVS12_01595 VSVS12_01595 VSVS12_01595 1742597 1743070 + hypothetical protein gene gene1594 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01595 VSVS12_01596 VSVS12_01596 VSVS12_01596 1743342 1744553 + uncharacterized protein Contains 1 GGDEF domain%3B Contains 1 HD domain gene gene1595 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01596 VSVS12_01597 VSVS12_01597 VSVS12_01597 1744662 1745549 - Cytidine deaminase This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis%3B Belongs to the cytidine and deoxycytidylate deaminase family%3B Contains 2 CMP/dCMP-type deaminase domains%3B KEGG: vpa:VP1298 cytidine deaminase gene gene1596 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01597 VSVS12_01598 VSVS12_01598 VSVS12_01598 1745737 1746414 - Holin-like protein CidB Increases the activity of extracellular murein hydrolases possibly by mediating their export via hole formation. Inhibited by the antiholin-like proteins LrgAB. In an unstressed cell%2C the LrgAB products probably inhibit the function of the CidAB proteins. When a cell is stressed by the addition of antibiotics or by other factors in the environment%2C the CidAB proteins possibly oligomerize within the bacterial cell membrane%2C creating lesions that disrupt the proton motive force%2C which in turn results in loss of cell viability. These lesions are also hypothesized to regulate the subsequent cell lysis by either allowing the murein hydrolases access to the cell wall substrate and/or regulating their activity by a possible change in the cell wall pH that results from loss of membrane potential%3B Belongs to the CidB/LrgB family. CidB subfamily gene gene1597 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01598 VSVS12_01599 VSVS12_01599 VSVS12_01599 1746414 1746833 - UPF0299 membrane protein Belongs to the UPF0299 family gene gene1598 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01599 VSVS12_01600 VSVS12_01600 sbcB sbcB 1746823 1748259 - Exodeoxyribonuclease I Degrades single-stranded DNA (ssDNA) in a highly processive manner. Also functions as a DNA deoxyribophosphodiesterase that releases deoxyribose-phosphate moieties following the cleavage of DNA at an apurinic/apyrimidinic (AP) site by either an AP endonuclease or AP lyase%3B Contains 1 exonuclease C-terminal domain%3B Contains 1 exonuclease domain%3B KEGG: vch:VC1234 exodeoxyribonuclease I gene gene1599 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01600 VSVS12_01601 VSVS12_01601 VSVS12_01601 1748467 1748844 - 2-iminobutanoate/2-iminopropanoate deaminase Belongs to the RutC family%3B KEGG: psf:PSE_1250 2-iminobutanoate/2-iminopropanoate deaminase gene gene1600 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01601 VSVS12_01602 VSVS12_01602 VSVS12_01602 1749154 1750230 + Serine-type D-Ala-D-Ala carboxypeptidase Catalyzes distinct carboxypeptidation and transpeptidation reactions during the last stages of wall peptidoglycan synthesis. Mistaking a beta-lactam antibiotic molecule for a normal substrate (i. e. a D-alanyl-D-alanine- terminated peptide)%2C it becomes immobilized in the form of a long- lived%2C serine-ester-linked acyl enzyme and thus behave as penicillin-binding protein (PBP). Belongs to the peptidase S12 family%3B KEGG: rer:RER_26670 D-alanyl-D-alanine carboxypeptidase gene gene1601 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01602 VSVS12_01603 VSVS12_01603 VSVS12_01603 1750304 1750984 - uncharacterized protein To yeast YER004W%3B KEGG: crg:105330969 oxidoreductase%3B With NAD(+) or NADP(+) as acceptor gene gene1602 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01603 VSVS12_01604 VSVS12_01604 VSVS12_01604 1751688 1752299 + uncharacterized protein Belongs to the flavoredoxin family gene gene1603 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01604 VSVS12_01605 VSVS12_01605 cobU cobU 1752313 1753341 + Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5%2C6- dimethylbenzimidazole (DMB)%3B Belongs to the CobT family%3B KEGG: vtu:IX91_06900 nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase gene gene1604 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01605 VSVS12_01606 VSVS12_01606 cobS cobS 1753341 1754120 + Adenosylcobinamide-GDP ribazoletransferase Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate%3B Belongs to the CobS family%3B KEGG: spl:Spea_3379 adenosylcobinamide-GDP ribazoletransferase gene gene1605 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01606 VSVS12_01607 VSVS12_01607 cobP cobP 1754117 1754644 + Adenosylcobinamide kinase Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate%3B Belongs to the CobU/CobP family%3B KEGG: rru:Rru_A0670 adenosylcobinamide kinase / adenosylcobinamide-phosphate guanylyltransferase gene gene1606 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01607 VSVS12_01608 VSVS12_01608 cobC cobC 1754649 1755275 + Adenosylcobalamin/alpha-ribazole phosphatase KEGG: vpa:VP1307 alpha-ribazole phosphatase gene gene1607 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01608 VSVS12_01609 VSVS12_01609 VSVS12_01609 1755287 1757074 + hypothetical protein gene gene1608 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01609 VSVS12_01610 VSVS12_01610 astE astE 1757325 1758353 + Succinylglutamate desuccinylase Transforms N(2)-succinylglutamate into succinate and glutamate%3B Belongs to the AspA/AstE family. Succinylglutamate desuccinylase subfamily%3B KEGG: vch:VC1242 succinylglutamate desuccinylase gene gene1609 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01610 VSVS12_01611 VSVS12_01611 VSVS12_01611 1758463 1759458 + putative ABC transporter permease protein YclN Probably part of an ABC transporter complex. Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily gene gene1610 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01611 VSVS12_01612 VSVS12_01612 btuD btuD 1759445 1760200 + Vitamin B12-transporting ATPase Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system%3B Belongs to the ABC transporter superfamily. Vitamin B12 importer (TC 3. A. 1. 13. 1) family%3B Contains 1 ABC transporter domain%3B KEGG: vpa:VP1312 vitamin B12 transport system ATP-binding protein gene gene1611 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01612 VSVS12_01613 VSVS12_01613 VSVS12_01613 1760235 1760747 - Ribosomal-protein-alanine N-acetyltransferase KEGG: bha:BH1961 ribosomal-protein-alanine N-acetyltransferase gene gene1612 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01613 VSVS12_01614 VSVS12_01614 VSVS12_01614 1760834 1761409 - hypothetical protein gene gene1613 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01614 VSVS12_01615 VSVS12_01615 VSVS12_01615 1761558 1762124 - hypothetical protein gene gene1614 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01615 VSVS12_01616 VSVS12_01616 VSVS12_01616 1762181 1763389 - hypothetical protein May be involved in either the transport or processing of arabinose polymers. Belongs to the major facilitator superfamily gene gene1615 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01616 VSVS12_01617 VSVS12_01617 VSVS12_01617 1763489 1764385 + SDS degradation transcriptional activation protein Activates the transcription of the sdsA gene for sodium dodecyl sulfate (SDS) degradation. Contains 1 HTH lysR-type DNA-binding domain gene gene1616 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01617 VSVS12_01618 VSVS12_01618 VSVS12_01618 1764446 1765675 - putative membrane protein Belongs to the NRAMP family gene gene1617 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01618 VSVS12_01619 VSVS12_01619 rocF rocF 1766090 1767013 + Arginase Belongs to the arginase family%3B KEGG: vfu:vfu_B00012 arginase gene gene1618 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01619 VSVS12_01620 VSVS12_01620 VSVS12_01620 1767082 1767309 - hypothetical protein gene gene1619 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01620 VSVS12_01621 VSVS12_01621 VSVS12_01621 1767449 1767943 + uncharacterized protein gene gene1620 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01621 VSVS12_01622 VSVS12_01622 rlmF rlmF 1767954 1769111 + 23S rRNA (adenine(1618)-N(6))-methyltransferase Specifically methylates the adenine in position 1618 of 23S rRNA%3B Belongs to the methyltransferase superfamily. METTL16/RlmF family%3B KEGG: vsp:VS_1679 23S rRNA (adenine1618-N6)-methyltransferase gene gene1621 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01622 VSVS12_01623 VSVS12_01623 VSVS12_01623 1769098 1769214 - hypothetical protein gene gene1622 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01623 VSVS12_01624 VSVS12_01624 VSVS12_01624 1769211 1769972 - uncharacterized protein gene gene1623 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01624 VSVS12_01625 VSVS12_01625 metA metA 1770156 1771097 - Homoserine O-succinyltransferase Belongs to the HTS family%3B KEGG: eco:b4013 homoserine O-succinyltransferase gene gene1624 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01625 VSVS12_01626 VSVS12_01626 VSVS12_01626 1771227 1771604 + hypothetical protein gene gene1625 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01626 VSVS12_01627 VSVS12_01627 VSVS12_01627 1771711 1772853 - hypothetical protein gene gene1626 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01627 VSVS12_01628 VSVS12_01628 VSVS12_01628 1772850 1773998 - hypothetical protein gene gene1627 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01628 VSVS12_01629 VSVS12_01629 VSVS12_01629 1773998 1774972 - 36 kDa antigen Belongs to the membrane fusion protein (MFP) (TC 8. A. 1) family gene gene1628 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01629 VSVS12_01630 VSVS12_01630 VSVS12_01630 1774982 1776379 - hypothetical protein gene gene1629 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01630 VSVS12_01631 VSVS12_01631 cpdP cpdP 1776678 1779818 + 3'%2C5'-cyclic-nucleotide phosphodiesterase KEGG: eba:ebA1682 3'%2C5'-cyclic-nucleotide phosphodiesterase gene gene1630 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01631 VSVS12_01632 VSVS12_01632 VSVS12_01632 1779974 1780519 + hypothetical protein gene gene1631 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01632 VSVS12_01633 VSVS12_01633 bcrC bcrC 1780516 1781934 + Undecaprenyl-diphosphate phosphatase KEGG: ahh:RY45_20895 undecaprenyl-diphosphatase gene gene1632 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01633 VSVS12_01634 VSVS12_01634 VSVS12_01634 1781987 1783627 - Methyl-accepting chemotaxis protein PctC Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment%2C transduce a signal from the outside to the inside of the cell%2C and facilitate sensory adaptation through the variation of the level of methylation. Responds to L-His%2C L-Pro and GABA. Also involved in repellent responses to trichloroethylene (TCE)%2C chloroform and methylthiocyanate%3B Contains 1 cache domain%3B Contains 1 HAMP domain%3B Contains 1 methyl-accepting transducer domain gene gene1633 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01634 VSVS12_01635 VSVS12_01635 queE queE 1783961 1784626 + 7-carboxy-7-deazaguanine synthase Catalyzes the conversion of 6-carboxy-5%2C6%2C7%2C8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG)%3B Belongs to the radical SAM superfamily. 7-carboxy-7- deazaguanine synthase family%3B KEGG: vch:VC1365 7-carboxy-7-deazaguanine synthase gene gene1634 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01635 VSVS12_01636 VSVS12_01636 queC queC 1784640 1785335 + 7-cyano-7-deazaguanine synthase Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))%3B Belongs to the QueC family%3B KEGG: eco:b0444 7-cyano-7-deazaguanine synthase gene gene1635 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01636 VSVS12_01637 VSVS12_01637 VSVS12_01637 1785343 1787268 - uncharacterized protein Contains 1 GGDEF domain gene gene1636 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01637 VSVS12_01638 VSVS12_01638 VSVS12_01638 1787469 1787819 - hypothetical protein gene gene1637 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01638 VSVS12_01639 VSVS12_01639 VSVS12_01639 1787921 1788532 - Outer membrane protein P.III Belongs to the OmpA family%3B Contains 1 OmpA-like domain gene gene1638 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01639 VSVS12_01640 VSVS12_01640 VSVS12_01640 1788534 1789841 - Outer membrane efflux protein BepC Involved in the efflux of toxic and relatively hydrophobic compounds. Influences survival inside the host%3B Belongs to the outer membrane factor (OMF) (TC 1. B. 17) family gene gene1639 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01640 VSVS12_01641 VSVS12_01641 VSVS12_01641 1790264 1795018 + Clumping factor Cell surface-associated protein implicated in virulence. Promotes bacterial attachment exclusively to the gamma-chain of human fibrinogen. Induces formation of bacterial clumps%2C which diminish the ability of group IIA phospholipase A2 to cause bacterial phospholipid hydrolysis and killing. Significantly decreases macrophage phagocytosis possibly thanks to the clumps%2C clumped bacteria being too large to be phagocytosed. Dominant factor responsible for human platelet aggregation%2C which may be an important mechanism for initiating infective endocarditis. Enhances spleen cell proliferative response in vitro%2C contributing significantly to the immunostimulatory activity of S. aureus%3B Belongs to the serine-aspartate repeat-containing protein (SDr) family gene gene1640 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01641 VSVS12_01642 VSVS12_01642 VSVS12_01642 1795318 1797495 + Serralysin One of the virulence factors produced during swarmer cell differentiation of the bacteria%2C which seems to be associated with pathogenesis. The protease activity is limited to IgA1%2C IgA2%2C as well as IgG degradation. Belongs to the peptidase M10B family%3B Contains 3 hemolysin-type calcium-binding repeats gene gene1641 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01642 VSVS12_01643 VSVS12_01643 rlmI rlmI 1797603 1798796 - 23S rRNA (cytosine(1962)-C(5))-methyltransferase Specifically methylates the cytosine at position 1962 (m5C1962) of 23S rRNA%3B Belongs to the methyltransferase superfamily. RlmI family%3B Contains 1 PUA domain%3B KEGG: vch:VC1354 23S rRNA (cytosine1962-C5)-methyltransferase gene gene1642 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01643 VSVS12_01644 VSVS12_01644 VSVS12_01644 1798909 1800312 - Halobacterial transducer protein Potentially involved in chemo- or phototactic signal transduction. Contains 1 methyl-accepting transducer domain%3B Contains 1 PAS (PER-ARNT-SIM) domain gene gene1643 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01644 VSVS12_01645 VSVS12_01645 acyP acyP 1800397 1800669 + Acylphosphatase Belongs to the acylphosphatase family%3B Contains 1 acylphosphatase-like domain%3B KEGG: vvu:VV1_2711 acylphosphatase gene gene1644 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01645 VSVS12_01646 VSVS12_01646 tusE tusE 1800726 1801055 - Sulfurtransferase TusE like protein Could be part of a sulfur-relay system%3B Belongs to the DsrC/TusE family%3B KEGG: eae:EAE_15440 tRNA 2-thiouridine synthesizing protein E%3B Sulfurtransferases gene gene1645 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01646 VSVS12_01647 VSVS12_01647 VSVS12_01647 1801170 1801838 - putative membrane protein Belongs to the BI1 family gene gene1646 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01647 VSVS12_01648 VSVS12_01648 aapP aapP 1802167 1802544 - Glutamate/glutamine/aspartate/asparagine transport ATP-binding protein BztD Part of a binding-protein-dependent transport system for glutamate%2C glutamine%2C aspartate%2C asparagine. Probably responsible for energy coupling to the transport system. Belongs to the ABC transporter superfamily%3B Contains 1 ABC transporter domain%3B KEGG: eco:b3271 general L-amino acid transport system ATP-binding protein%3B Acting on acid anhydrides%3B catalyzing transmembrane movement of substances gene gene1647 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01648 VSVS12_01649 VSVS12_01649 VSVS12_01649 1802610 1802915 - Spermidine/putrescine import ATP-binding protein PotA Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system%3B Belongs to the ABC transporter superfamily. Spermidine/putrescine importer (TC 3. A. 1. 11. 1) family%3B Contains 1 ABC transporter domain%3B KEGG: vvu:VV1_2706 general L-amino acid transport system ATP-binding protein%3B Acting on acid anhydrides%3B catalyzing transmembrane movement of substances gene gene1648 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01649 VSVS12_01650 VSVS12_01650 VSVS12_01650 1802932 1804029 - Inner membrane amino-acid ABC transporter permease protein Probably part of the binding-protein-dependent transport system YdhWXYZ for an amino aci%3B probably responsible for the translocation of the substrate across the membrane. Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily%3B Contains 1 ABC transmembrane type-1 domain gene gene1649 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01650 VSVS12_01651 VSVS12_01651 VSVS12_01651 1804031 1805227 - Putative amino-acid ABC transporter permease protein Probably part of the binding-protein-dependent transport system YdhWXYZ for an amino aci%3B probably responsible for the translocation of the substrate across the membrane. Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily%3B Contains 1 ABC transmembrane type-1 domain gene gene1650 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01651 VSVS12_01652 VSVS12_01652 VSVS12_01652 1805351 1806379 - Putative amino-acid ABC transporter-binding protein YhdW Probably part of the binding-protein-dependent transport system YdhWXYZ for an amino acid. Belongs to the bacterial solute-binding protein 3 family gene gene1651 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01652 VSVS12_01653 VSVS12_01653 cysG cysG 1806944 1807879 + Uroporphyrinogen-III C-methyltransferase Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally%2C it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme%3B In the N-terminal sectio%3B belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family%3B In the C-terminal sectio%3B belongs to the precorrin methyltransferase family%3B KEGG: buh:BUAMB_401 uroporphyrin-III C-methyltransferase / precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase gene gene1652 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01653 VSVS12_01654 VSVS12_01654 VSVS12_01654 1807942 1808427 - UPF0234 protein Belongs to the UPF0234 family gene gene1653 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01654 VSVS12_01655 VSVS12_01655 VSVS12_01655 1808449 1809504 - 3-deoxy-7-phosphoheptulonate synthase Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)%3B Belongs to the class-I DAHP synthase family%3B KEGG: vch:VC1507 3-deoxy-7-phosphoheptulonate synthase gene gene1654 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01655 VSVS12_01656 VSVS12_01656 VSVS12_01656 1809753 1810232 + hypothetical protein gene gene1655 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01656 VSVS12_01657 VSVS12_01657 VSVS12_01657 1810229 1811599 - hypothetical protein gene gene1656 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01657 VSVS12_01658 VSVS12_01658 VSVS12_01658 1811700 1812533 + Conserved virulence factor Contributes to the expression of virulence factors and to pathogenicity. Involved in the production of hemolysin%2C DNase%2C protease and protein A (By similarity)%3B Belongs to the CvfB family gene gene1657 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01658 VSVS12_01659 VSVS12_01659 rsmF rsmF 1812710 1814131 - 16S rRNA (cytosine(1407)-C(5))-methyltransferase Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA%3B Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family%3B KEGG: vcy:IX92_06810 16S rRNA (cytosine1407-C5)-methyltransferase gene gene1658 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01659 VSVS12_01660 VSVS12_01660 VSVS12_01660 1814274 1816907 - uncharacterized protein Belongs to the PqiB family gene gene1659 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01660 VSVS12_01661 VSVS12_01661 VSVS12_01661 1816900 1818192 - Paraquat-inducible protein Belongs to the PqiA family gene gene1660 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01661 VSVS12_01662 VSVS12_01662 VSVS12_01662 1818223 1820019 - Multidrug resistance ABC transporter ATP-binding and permease protein Efflux transporter for a variety of amphiphilic cationic compounds%2C including antibiotics%3B Belongs to the ABC transporter superfamily. Multidrug exporter LmrA (TC 3. A. 1. 117. 1) family%3B Contains 1 ABC transmembrane type-1 domain%3B Contains 1 ABC transporter domain gene gene1661 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01662 VSVS12_01663 VSVS12_01663 VSVS12_01663 1820223 1820591 + hypothetical protein Belongs to the free Met sulfoxide reductase family gene gene1662 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01663 VSVS12_01664 VSVS12_01664 VSVS12_01664 1820693 1821325 + RNA chaperone ProQ RNA chaperone with significant RNA binding%2C RNA strand exchange and RNA duplexing activities%3B Belongs to the ProQ family gene gene1663 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01664 VSVS12_01665 VSVS12_01665 ctpA ctpA 1821343 1823337 + C-terminal processing peptidase Involved in the cleavage of a C-terminal peptide of 11 residues from the precursor form of penicillin-binding protein 3 (PBP3). May be involved in protection of the bacterium from thermal and osmotic stresses. Belongs to the peptidase S41A family%3B Contains 1 PDZ (DHR) domain%3B KEGG: vch:VC1496 carboxyl-terminal processing protease gene gene1664 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01665 VSVS12_01666 VSVS12_01666 VSVS12_01666 1823471 1824133 + hypothetical protein gene gene1665 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01666 VSVS12_01667 VSVS12_01667 pepN pepN 1824283 1826889 + Membrane alanyl aminopeptidase Aminopeptidase N is involved in the degradation of intracellular peptides generated by protein breakdown during normal growth as well as in response to nutrient starvation. Belongs to the peptidase M1 family%3B KEGG: vch:VC1494 aminopeptidase N gene gene1666 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01667 VSVS12_01668 VSVS12_01668 VSVS12_01668 1826975 1827193 + hypothetical protein gene gene1667 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01668 VSVS12_01669 VSVS12_01669 gdh2 gdh2 1827425 1832266 + Glutamate dehydrogenase Involved in arginine catabolism by converting L- glutamate%2C into 2-oxoglutarate%2C which is then channeled into the tricarboxylic acid cycle. Can also utilize other amino acids of the glutamate family%3B Belongs to the Glu/Leu/Phe/Val dehydrogenases family%3B KEGG: vch:VC1492 glutamate dehydrogenase gene gene1668 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01669 VSVS12_01670 VSVS12_01670 pyrD pyrD 1832313 1833323 + Dihydroorotate dehydrogenase (quinone) Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor%3B Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily%3B KEGG: vpa:VP1601 dihydroorotate dehydrogenase gene gene1669 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01670 VSVS12_01671 VSVS12_01671 VSVS12_01671 1833493 1834038 + Cell division protein ZapC Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ%3B Belongs to the ZapC family gene gene1670 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01671 VSVS12_01672 VSVS12_01672 rlmL rlmL 1834582 1836708 + 23S rRNA (guanine(2445)-N(2))-methyltransferase Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA%3B Belongs to the methyltransferase superfamily. RlmKL family%3B Contains 1 THUMP domain%3B KEGG: vch:VC1488 23S rRNA (guanine2445-N2)-methyltransferase / 23S rRNA (guanine2069-N7)-methyltransferase gene gene1671 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01672 VSVS12_01673 VSVS12_01673 VSVS12_01673 1836769 1836963 + hypothetical protein gene gene1672 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01673 VSVS12_01674 VSVS12_01674 VSVS12_01674 1836941 1838857 + Fe(3+)-transporting ATPase Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily%3B Contains 2 ABC transporter domains%3B KEGG: mvr:X781_10300 iron(III) transport system ATP-binding protein gene gene1673 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01674 VSVS12_01675 VSVS12_01675 VSVS12_01675 1838865 1840505 + hypothetical protein gene gene1674 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01675 VSVS12_01676 VSVS12_01676 VSVS12_01676 1840673 1840846 + Ribosome modulation factor During stationary phase%2C converts 70S ribosomes to an inactive dimeric form (100S ribosomes)%3B Belongs to the ribosome modulation factor family gene gene1675 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01676 VSVS12_01677 VSVS12_01677 fabA fabA 1840977 1841495 - 3-hydroxyacyl-[acyl-carrier-protein] dehydratase Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16:0%2C being most active on intermediate chain length%3B Belongs to the thioester dehydratase family. FabA subfamily%3B KEGG: eco:b0954 3-hydroxyacyl-(acyl-carrier protein) dehydratase / trans-2-decenoyl-(acyl-carrier protein) isomerase gene gene1676 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01677 VSVS12_01678 VSVS12_01678 lonH lonH 1841566 1843209 - Putative Lon protease like protein Belongs to the peptidase S16 family%3B KEGG: vvu:VV1_2628 Lon-like ATP-dependent protease%3B Serine endopeptidases gene gene1677 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01678 VSVS12_01679 VSVS12_01679 VSVS12_01679 1843395 1843844 + Macrodomain Ter protein Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle. Prevents early segregation of duplicated Ter macrodomains during cell division. Binds specifically to matS%2C which is a 13 bp signature motif repeated within the Ter macrodomain%3B Belongs to the MatP family gene gene1678 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01679 VSVS12_01680 VSVS12_01680 VSVS12_01680 1843858 1844166 + hypothetical protein gene gene1679 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01680 VSVS12_01681 VSVS12_01681 VSVS12_01681 1845313 1845669 - hypothetical protein gene gene1680 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01681 VSVS12_01682 VSVS12_01682 ccoN ccoN 1845930 1847357 + Cytochrome-c oxidase Cbb3-type cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits CcoN and CcoO form the functional core of the enzyme complex. Subunits CcoP and CcoQ may optionally bind to the core. CcoN is the catalytic subunit of the enzyme. Electrons originating in cytochrome c or a quinol are transferred to the bimetallic center formed by a high-spin heme and copper B. The complex also functions as a proton pump%3B Belongs to the heme-copper respiratory oxidase family%3B KEGG: vch:VC1442 cytochrome c oxidase cbb3-type subunit I gene gene1681 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01682 VSVS12_01683 VSVS12_01683 VSVS12_01683 1847370 1847990 + hypothetical protein gene gene1682 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01683 VSVS12_01684 VSVS12_01684 VSVS12_01684 1848001 1848174 + hypothetical protein gene gene1683 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01684 VSVS12_01685 VSVS12_01685 VSVS12_01685 1848174 1849154 + Cbb3-type cytochrome c oxidase subunit CcoP1 C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex. CcoP subunit is required for transferring electrons from donor cytochrome c via its heme groups to CcoO subunit. From there%2C electrons are shuttled to the catalytic binuclear center of CcoN subunit where oxygen reduction takes place. The complex also functions as a proton pump (By similarity)%3B Belongs to the CcoP / FixP family%3B Contains 2 cytochrome c domains gene gene1684 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01685 VSVS12_01686 VSVS12_01686 VSVS12_01686 1849235 1849714 + hypothetical protein gene gene1685 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01686 VSVS12_01687 VSVS12_01687 copB copB 1849722 1852103 + Cu(2+)-exporting ATPase Involved in copper export%3B Belongs to the cation transport ATPase (P-type) (TC 3. A. 3) family. Type IB subfamily%3B Contains 2 HMA domains%3B KEGG: vvu:VV1_2614 Cu2+-exporting ATPase gene gene1686 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01687 VSVS12_01688 VSVS12_01688 VSVS12_01688 1852109 1852270 + hypothetical protein gene gene1687 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01688 VSVS12_01689 VSVS12_01689 VSVS12_01689 1852267 1852932 + hypothetical protein gene gene1688 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01689 VSVS12_01690 VSVS12_01690 VSVS12_01690 1853030 1853776 + Fumarate and nitrate reduction regulatory protein Global transcription factor that controls the expression of over 100 target genes in response to anoxia. It facilitates the adaptation to anaerobic growth conditions by regulating the expression of gene products that are involved in anaerobic energy metabolism. When the terminal electron acceptor%2C O(2)%2C is no longer available%2C it represses the synthesis of enzymes involved in aerobic respiration and increases the synthesis of enzymes required for anaerobic respiration (By similarity)%3B Contains 1 cyclic nucleotide-binding domain%3B Contains 1 HTH crp-type DNA-binding domain gene gene1689 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01690 VSVS12_01691 VSVS12_01691 VSVS12_01691 1853929 1854876 + Universal stress protein Required for resistance to DNA-damaging agents%3B Belongs to the universal stress protein A family gene gene1690 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01691 VSVS12_01692 VSVS12_01692 VSVS12_01692 1855046 1855978 + tRNA 2-thiocytidine biosynthesis protein TtcA Required for the thiolation of cytidine in position 32 of tRNA%2C to form 2-thiocytidine (s(2)C32)%3B Belongs to the TtcA family gene gene1691 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01692 VSVS12_01693 VSVS12_01693 VSVS12_01693 1856104 1856763 - hypothetical protein gene gene1692 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01693 VSVS12_01694 VSVS12_01694 VSVS12_01694 1856763 1857590 - Protein bax gene gene1693 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01694 VSVS12_01695 VSVS12_01695 VSVS12_01695 1857583 1858380 - hypothetical protein gene gene1694 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01695 VSVS12_01696 VSVS12_01696 pstB pstB 1858801 1859940 + Phosphate-transporting ATPase Part of the ABC transporter complex ZnuABC involved in zinc import. Responsible for energy coupling to the transport system%3B Belongs to the ABC transporter superfamily. Zinc importer (TC 3. A. 1. 15. 5) family%3B Contains 1 ABC transporter domain%3B KEGG: nga:Ngar_c09820 phosphate transport system ATP-binding protein gene gene1695 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01696 VSVS12_01697 VSVS12_01697 VSVS12_01697 1859921 1860781 + Spermidine/putrescine transport system permease protein Required for the activity of the bacterial periplasmic transport system of putrescine and spermidine. Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily%3B Contains 1 ABC transmembrane type-1 domain gene gene1696 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01697 VSVS12_01698 VSVS12_01698 VSVS12_01698 1860781 1861551 + Spermidine/putrescine transport system permease protein PotC Required for the activity of the bacterial periplasmic transport system of putrescine and spermidine%3B Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily%3B Contains 1 ABC transmembrane type-1 domain gene gene1697 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01698 VSVS12_01699 VSVS12_01699 VSVS12_01699 1861649 1862683 + Spermidine/putrescine-binding periplasmic protein Required for the activity of the bacterial periplasmic transport system of putrescine and spermidine. Polyamine binding protein (By similarity)%3B Belongs to the bacterial solute-binding protein PotD/PotF family gene gene1698 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01699 VSVS12_01700 VSVS12_01700 VSVS12_01700 1862861 1863898 + Spermidine/putrescine-binding periplasmic protein Required for the activity of the bacterial periplasmic transport system of putrescine and spermidine. Polyamine binding protein%3B Belongs to the bacterial solute-binding protein PotD/PotF family gene gene1699 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01700 VSVS12_01701 VSVS12_01701 npdA npdA 1864001 1864735 - NAD-dependent protein deacylase NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form%3B Belongs to the sirtuin family. Class III subfamily%3B Contains 1 deacetylase sirtuin-type domain%3B KEGG: vvu:VV1_2599 NAD-dependent deacetylase%3B In linear amides gene gene1700 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01701 VSVS12_01702 VSVS12_01702 VSVS12_01702 1864949 1866169 - Putative ammonium transporter Belongs to the ammonia transporter channel (TC 1. A. 11. 2) family gene gene1701 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01702 VSVS12_01703 VSVS12_01703 VSVS12_01703 1866585 1867001 - hypothetical protein gene gene1702 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01703 VSVS12_01704 VSVS12_01704 VSVS12_01704 1866985 1868040 - hypothetical protein gene gene1703 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01704 VSVS12_01705 VSVS12_01705 VSVS12_01705 1868055 1868663 - Formate dehydrogenase iron-sulfur subunit This chain is an electron transfer unit containing 18 cysteine residues%2C 16 of which occur in four clusters. Contains 3 4Fe-4S ferredoxin-type domains gene gene1704 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01705 VSVS12_01706 VSVS12_01706 VSVS12_01706 1868675 1871530 - Formate dehydrogenase Belongs to the prokaryotic molybdopterin-containing oxidoreductase family%3B Contains 1 4Fe-4S Mo/W bis-MGD-type domain%3B KEGG: vcf:IR04_12795 formate dehydrogenase major subunit gene gene1705 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01706 VSVS12_01707 VSVS12_01707 VSVS12_01707 1871546 1871743 - hypothetical protein gene gene1706 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01707 VSVS12_01708 VSVS12_01708 VSVS12_01708 1871806 1872432 - hypothetical protein gene gene1707 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01708 VSVS12_01709 VSVS12_01709 VSVS12_01709 1872442 1874103 - hypothetical protein gene gene1708 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01709 VSVS12_01710 VSVS12_01710 VSVS12_01710 1874404 1875114 - hypothetical protein gene gene1709 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01710 VSVS12_01711 VSVS12_01711 VSVS12_01711 1875104 1875553 - hypothetical protein gene gene1710 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01711 VSVS12_01712 VSVS12_01712 VSVS12_01712 1875906 1876736 + Protein FdhD like protein Necessary for formate dehydrogenase activity. Belongs to the FdhD family gene gene1711 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01712 VSVS12_01713 VSVS12_01713 VSVS12_01713 1876920 1878809 + Putative methyl-accepting chemotaxis protein YoaH Contains 1 HAMP domain%3B Contains 1 methyl-accepting transducer domain gene gene1712 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01713 VSVS12_01714 VSVS12_01714 VSVS12_01714 1879005 1880597 - Iron-chelate-transporting ATPase Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily%3B Contains 2 ABC transporter domains%3B KEGG: bto:WQG_3490 iron complex transport system ATP-binding protein gene gene1713 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01714 VSVS12_01715 VSVS12_01715 VSVS12_01715 1880684 1881571 - putative HTH-type transcriptional regulator in ibpB-leuC intergenic region Contains 1 HTH lysR-type DNA-binding domain gene gene1714 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01715 VSVS12_01716 VSVS12_01716 VSVS12_01716 1881706 1882647 + Alcohol dehydrogenase Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily%3B KEGG: esi:Exig_1536 alcohol dehydrogenase gene gene1715 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01716 VSVS12_01717 VSVS12_01717 VSVS12_01717 1882904 1885249 + hypothetical protein gene gene1716 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01717 VSVS12_01718 VSVS12_01718 VSVS12_01718 1885251 1886129 + Small-conductance mechanosensitive channel Mechanosensitive channel that participates in the regulation of osmotic pressure changes within the cell. Forms an ion channel of 1. 0 nanosiemens conductance with a slight preference for anions. The channel is sensitive to voltage (By similarity)%3B Belongs to the MscS (TC 1. A. 23) family gene gene1717 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01718 VSVS12_01719 VSVS12_01719 VSVS12_01719 1886212 1889079 - Metalloprotease StcE Virulence factor that contributes to intimate adherence of enterohemorrhagic E. coli (EHEC) O157:H7 to host cells. Is able to cleave the secreted human mucin 7 (MUC7) and the glycoprotein 340 (DMBT1/GP340). Also cleaves human C1 inhibitor (SERPING1)%2C a regulator of multiple inflammatory pathways%2C and binds and localizes it to bacterial and host cell surfaces%2C protecting them from complement-mediated lysis. Therefore%2C the current model proposes two roles for StcE during infection: it acts first as a mucinase%2C allowing passage of EHEC through the oral cavity by cleaving the salivary glycoproteins that are responsible for bacterial aggregation. Similarly%2C in the colon%2C StcE cleaves the glycoproteins that protect the intestinal epithelial surface%2C allowing EHEC to come into close contact with host cell membranes. Secondly%2C it acts as an anti-inflammatory agent by localizing SERPING1 to cell membranes%3B Contains 1 peptidase M66 domain gene gene1718 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01719 VSVS12_01720 VSVS12_01720 VSVS12_01720 1889423 1891468 - Histidine kinase Contains 1 HAMP domain%3B Contains 1 methyl-accepting transducer domain%3B KEGG: vvy:VV1711 two-component system%2C NtrC family%2C sensor kinase gene gene1719 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01720 VSVS12_01721 VSVS12_01721 VSVS12_01721 1891458 1892909 - Transcriptional regulatory protein The N-terminus of this protein is required for the transcriptional expression of both major outer membrane protein genes ompF and omp%3B its C-terminal moiety mediates the multimerization of the OmpR protein. As a multimer%2C it turns on the expression of the ompC gen%3B as a monomer%2C it turns on the expression of the ompF gene (By similarity)%3B Contains 1 OmpR/PhoB-type DNA-binding domain%3B Contains 1 response regulatory domain gene gene1720 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01721 VSVS12_01722 VSVS12_01722 VSVS12_01722 1893159 1893980 + Putative ABC transporter anion-binding protein Part of an ABC transporter complex involved in anions import gene gene1721 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01722 VSVS12_01723 VSVS12_01723 VSVS12_01723 1893987 1894685 + putative anion ABC transporter permease protein Part of an ABC transporter complex involved in anions import (Probable). Responsible for the translocation of the substrate across the membrane (By similarity)%3B Belongs to the binding-protein-dependent transport system permease family%3B Contains 1 ABC transmembrane type-1 domain gene gene1722 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01723 VSVS12_01724 VSVS12_01724 tupC tupC 1894695 1895411 + Tungstate-importing ATPase Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochrome%3B once thought to export heme%2C this seems not to be the case%2C but its exact role is uncertain. Responsible for energy coupling to the transport system%3B Belongs to the ABC transporter superfamily. CcmA exporter (TC 3. A. 1. 107) family%3B Contains 1 ABC transporter domain%3B KEGG: vch:VC1525 tungstate transport system ATP-binding protein gene gene1723 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01724 VSVS12_01725 VSVS12_01725 mobA mobA 1895389 1895976 + Molybdenum cofactor guanylyltransferase Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor%3B Belongs to the MobA family%3B KEGG: vch:VC1526 molybdopterin-guanine dinucleotide biosynthesis protein A gene gene1724 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01725 VSVS12_01726 VSVS12_01726 VSVS12_01726 1895973 1897790 + Molybdopterin-guanine dinucleotide biosynthesis adapter protein GTP-binding protein that is not required for the biosynthesis of Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor%2C and not necessary for the formation of active molybdoenzymes using this form of molybdenum cofactor. May act as an adapter protein to achieve the efficient biosynthesis and utilization of MGD. Displays a weak intrinsic GTPase activity. Is also able to bind the nucleotides ATP%2C TTP and GDP%2C but with lower affinity than GTP%3B Belongs to the MobB family gene gene1725 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01726 VSVS12_01727 VSVS12_01727 VSVS12_01727 1897853 1898119 + hypothetical protein gene gene1726 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01727 VSVS12_01728 VSVS12_01728 nagK nagK 1898210 1899118 - N-acetylglucosamine kinase Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation%2C yielding GlcNAc-6-P%3B Belongs to the ROK (NagC/XylR) family. NagK subfamily%3B KEGG: eco:b1119 N-acetylglucosamine kinase gene gene1727 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01728 VSVS12_01729 VSVS12_01729 VSVS12_01729 1899243 1899899 - DTW domain-containing protein YfiP Belongs to the DTW family gene gene1728 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01729 VSVS12_01730 VSVS12_01730 erg3 erg3 1900064 1900852 + Delta(7)-sterol 5(6)-desaturase KEGG: hch:HCH_01597 delta7-sterol 5-desaturase gene gene1729 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01730 VSVS12_01731 VSVS12_01731 VSVS12_01731 1901148 1903181 - Methyl-accepting chemotaxis protein HlyB Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment%2C transduce a signal from the outside to the inside of the cell%2C and facilitate sensory adaptation through the variation of the level of methylation%3B Contains 1 HAMP domain%3B Contains 1 methyl-accepting transducer domain gene gene1730 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01731 VSVS12_01732 VSVS12_01732 VSVS12_01732 1903278 1903790 + putative endopeptidase NlpC Belongs to the peptidase C40 family gene gene1731 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01732 VSVS12_01733 VSVS12_01733 VSVS12_01733 1903815 1904159 - hypothetical protein gene gene1732 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01733 VSVS12_01734 VSVS12_01734 VSVS12_01734 1904640 1905506 + Protein-ribulosamine 3-kinase Belongs to the fructosamine kinase family%3B KEGG: nve:NEMVE_v1g166358 protein-ribulosamine 3-kinase gene gene1733 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01734 VSVS12_01735 VSVS12_01735 VSVS12_01735 1905724 1905927 + hypothetical protein gene gene1734 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01735 VSVS12_01736 VSVS12_01736 VSVS12_01736 1906015 1906635 - Riboflavin synthase Catalyzes the dismutation of two molecules of 6%2C7- dimethyl-8-ribityllumazine%2C resulting in the formation of riboflavin and 5-amino-6-(D-ribitylamino)uracil%3B Contains 2 lumazine-binding repeats%3B KEGG: eco:b1662 riboflavin synthase gene gene1735 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01736 VSVS12_01737 VSVS12_01737 VSVS12_01737 1907180 1908550 + Multidrug resistance protein NorM Multidrug efflux pump that functions as a Na(+)/drug antiporter. Confers resistance to norfloxacin%2C ciprofloxacin%2C ofloxacin%2C daunomycin%2C doxorubicin%2C streptomycin%2C kanamycin%2C ethidium bromide and acriflavine%3B Belongs to the multi antimicrobial extrusion (MATE) (TC 2. A. 66. 1) family gene gene1736 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01737 VSVS12_01738 VSVS12_01738 VSVS12_01738 1908587 1909753 + hypothetical protein gene gene1737 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01738 VSVS12_01739 VSVS12_01739 VSVS12_01739 1909893 1910090 - hypothetical protein gene gene1738 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01739 VSVS12_01740 VSVS12_01740 VSVS12_01740 1910344 1914018 + hypothetical protein gene gene1739 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01740 VSVS12_01741 VSVS12_01741 VSVS12_01741 1914118 1915347 + hypothetical protein gene gene1740 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01741 VSVS12_01742 VSVS12_01742 VSVS12_01742 1915693 1916322 + Leucine efflux protein Exporter of leucine%3B Belongs to the rht family gene gene1741 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01742 VSVS12_01743 VSVS12_01743 VSVS12_01743 1916500 1916910 - hypothetical protein gene gene1742 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01743 VSVS12_01744 VSVS12_01744 VSVS12_01744 1917042 1917851 - hypothetical protein gene gene1743 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01744 VSVS12_01745 VSVS12_01745 VSVS12_01745 1918155 1918343 - hypothetical protein gene gene1744 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01745 VSVS12_01746 VSVS12_01746 ribB ribB 1918399 1919055 + 3%2C4-dihydroxy-2-butanone-4-phosphate synthase Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3%2C4-dihydroxy-2-butanone 4-phosphate%3B Belongs to the DHBP synthase family%3B KEGG: hru:Halru_2254 3%2C4-dihydroxy 2-butanone 4-phosphate synthase gene gene1745 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01746 VSVS12_01747 VSVS12_01747 VSVS12_01747 1920278 1921534 - Adenylosuccinate synthase Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP%3B Belongs to the adenylosuccinate synthetase family%3B KEGG: vvu:VV2_0768 adenylosuccinate synthase gene gene1746 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01747 VSVS12_01748 VSVS12_01748 VSVS12_01748 1921712 1922599 + HTH-type transcriptional regulator CfxR Trans-acting transcriptional regulator of RuBisCO genes (cfxLS) expression. Contains 1 HTH lysR-type DNA-binding domain gene gene1747 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01748 VSVS12_01749 VSVS12_01749 VSVS12_01749 1923023 1924294 + Hydroxymethylglutaryl-CoA reductase (NADPH) Catalyzes the NADPH-dependent reductive deacylation of (S)-3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) to (R)-mevalonate. Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP)%2C a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids. Is also able to catalyze the reduction of mevaldehyde to mevalonate and the oxidative acylation of mevaldehyde to HMG-CoA%3B Belongs to the HMG-CoA reductase family%3B KEGG: vch:VCA0723 hydroxymethylglutaryl-CoA reductase (NADPH) gene gene1748 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01749 VSVS12_01750 VSVS12_01750 VSVS12_01750 1924366 1925499 + hypothetical protein gene gene1749 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01750 VSVS12_01751 VSVS12_01751 VSVS12_01751 1925708 1926433 + hypothetical protein gene gene1750 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01751 VSVS12_01752 VSVS12_01752 VSVS12_01752 1926761 1929700 + hypothetical protein gene gene1751 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01752 VSVS12_01753 VSVS12_01753 VSVS12_01753 1929808 1930689 - hypothetical protein gene gene1752 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01753 VSVS12_01754 VSVS12_01754 VSVS12_01754 1930771 1931586 - Dodecenoyl-CoA isomerase Decarboxylases ethylmalonyl-CoA decarboxylase%2C a potentially toxic metabolite%2C to form butyryl-CoA%2C suggesting it might be involved in metabolite proofreading. Also has methylmalonyl-CoA decarboxylase activity at lower level (By similarity)%3B Belongs to the enoyl-CoA hydratase/isomerase family%3B KEGG: tcr:509261. 30 3%2C2-trans-enoyl-CoA isomerase%2C mitochondrial gene gene1753 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01754 VSVS12_01755 VSVS12_01755 VSVS12_01755 1931770 1932720 + putative HTH-type transcriptional regulator LtrA Contains 1 HTH lysR-type DNA-binding domain gene gene1754 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01755 VSVS12_01756 VSVS12_01756 VSVS12_01756 1932900 1933385 - hypothetical protein gene gene1755 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01756 VSVS12_01757 VSVS12_01757 VSVS12_01757 1933516 1934205 + hypothetical protein gene gene1756 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01757 VSVS12_01758 VSVS12_01758 VSVS12_01758 1934283 1935476 - Transposase for insertion sequence element IS1001 Involved in the transposition of the insertion sequence. Belongs to the transposase 12 family gene gene1757 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01758 VSVS12_01759 VSVS12_01759 VSVS12_01759 1935640 1937226 - hypothetical protein gene gene1758 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01759 VSVS12_01760 VSVS12_01760 VSVS12_01760 1937201 1938409 - hypothetical protein gene gene1759 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01760 VSVS12_01761 VSVS12_01761 VSVS12_01761 1938469 1940223 - hypothetical protein gene gene1760 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01761 VSVS12_01762 VSVS12_01762 murP murP 1940484 1941947 - Protein-N(pi)-phosphohistidine--sugar phosphotransferase The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS)%2C a major carbohydrate active -transport system%2C catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in N-acetylmuramic acid (MurNAc) transport%2C yielding cytoplasmic MurNAc-6-P. Is also able to take up anhydro-N-acetylmuramic acid (anhMurNAc)%2C but cannot phosphorylate the carbon 6%2C probably because of the 1%2C6-anhydro ring (By similarity)%3B Contains 1 PTS EIIB type-1 domain%3B Contains 1 PTS EIIC type-1 domain%3B KEGG: vpa:VPA1744 PTS system%2C N-acetylmuramic acid-specific IIB component gene gene1761 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01762 VSVS12_01763 VSVS12_01763 VSVS12_01763 1942059 1942973 - N-acetylmuramic acid 6-phosphate etherase Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate%2C producing GlcNAc 6- phosphate and D-lactate. Together with AnmK%2C is also required for the utilization of anhydro-N-acetylmuramic acid (anhMurNAc) either imported from the medium or derived from its own cell wall murein%2C and thus plays a role in cell wall recycling%3B Belongs to the GCKR-like family. MurNAc-6-P etherase subfamily%3B Contains 1 SIS domain%3B KEGG: pmr:PMI3138 N-acetylmuramic acid 6-phosphate etherase gene gene1762 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01763 VSVS12_01764 VSVS12_01764 VSVS12_01764 1943220 1944065 + HTH-type transcriptional regulator MurR Represses the expression of the murPQ operon involved in the uptake and degradation of N-acetylmuramic acid (MurNAc). Binds to two adjacent inverted repeats within the operator region. MurNAc 6-phosphate%2C the substrate of MurQ%2C is the specific inducer that weakens binding of MurR to the operator%3B Contains 1 HTH rpiR-type DNA-binding domain%3B Contains 1 SIS domain gene gene1763 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01764 VSVS12_01765 VSVS12_01765 lig1 lig1 1944073 1944939 - DNA ligase (ATP) Catalyzes efficient strand joining on a single nicked DNA. Belongs to the ATP-dependent DNA ligase family%3B KEGG: vsa:VSAL_I1366 DNA ligase 1 gene gene1764 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01765 VSVS12_01766 VSVS12_01766 VSVS12_01766 1945203 1945523 + hypothetical protein gene gene1765 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01766 VSVS12_01767 VSVS12_01767 VSVS12_01767 1945542 1946378 + hypothetical protein gene gene1766 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01767 VSVS12_01768 VSVS12_01768 VSVS12_01768 1946365 1947516 + hypothetical protein gene gene1767 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01768 VSVS12_01769 VSVS12_01769 VSVS12_01769 1947513 1948475 + hypothetical protein gene gene1768 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01769 VSVS12_01770 VSVS12_01770 VSVS12_01770 1948475 1949167 + hypothetical protein gene gene1769 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01770 VSVS12_01771 VSVS12_01771 baeS baeS 1949188 1951491 + Histidine kinase Ethylene receptor related to bacterial two-component regulators. Acts as negative regulator of ethylene signaling. May delay the transition from the vegetative stage to the floral stage by upregulating GI (GIGANTEA) and RCN1 and cause starch accumulation in stems by down-regulating the alpha-amylase AMY3D%3B Belongs to the ethylene receptor family%3B Contains 1 GAF domain%3B Contains 1 histidine kinase domain%3B Contains 1 response regulatory domain%3B KEGG: mah:MEALZ_3850 two-component system%2C OmpR family%2C sensor histidine kinase BaeS gene gene1770 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01771 VSVS12_01772 VSVS12_01772 VSVS12_01772 1951527 1952996 + DNA-binding response regulator MtrA Member of the two-component regulatory system MtrA/MtrB%3B Contains 1 OmpR/PhoB-type DNA-binding domain%3B Contains 1 response regulatory domain gene gene1771 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01772 VSVS12_01773 VSVS12_01773 VSVS12_01773 1952974 1954041 + hypothetical protein gene gene1772 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01773 VSVS12_01774 VSVS12_01774 VSVS12_01774 1954164 1955378 + Lipopolysaccharide core biosynthesis glycosyltransferase LpsE Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily%3B KEGG: vfi:VF_A1028 null%3B Hexosyltransferases gene gene1773 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01774 VSVS12_01775 VSVS12_01775 VSVS12_01775 1955535 1956566 + hypothetical protein gene gene1774 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01775 VSVS12_01776 VSVS12_01776 VSVS12_01776 1956570 1958063 + hypothetical protein gene gene1775 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01776 VSVS12_01777 VSVS12_01777 VSVS12_01777 1958060 1959460 + hypothetical protein gene gene1776 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01777 VSVS12_01778 VSVS12_01778 wbbJ wbbJ 1959531 1960247 + Putative acetyltransferase YvoF Belongs to the transferase hexapeptide repeat family%3B KEGG: pfl:PFL_5101 lipopolysaccharide O-acetyltransferase%3B Transferring groups other than amino-acyl groups gene gene1777 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01778 VSVS12_01779 VSVS12_01779 VSVS12_01779 1960240 1961181 + Putative teichuronic acid biosynthesis glycosyltransferase TuaH Belongs to the glycosyltransferase group 1 family%3B KEGG: vfi:VF_A1033 null%3B Hexosyltransferases gene gene1778 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01779 VSVS12_01780 VSVS12_01780 VSVS12_01780 1961285 1962493 + hypothetical protein gene gene1779 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01780 VSVS12_01781 VSVS12_01781 VSVS12_01781 1962490 1962690 + hypothetical protein gene gene1780 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01781 VSVS12_01782 VSVS12_01782 VSVS12_01782 1962687 1964126 + hypothetical protein gene gene1781 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01782 VSVS12_01783 VSVS12_01783 waaB waaB 1964240 1965346 + Lipopolysaccharide core biosynthesis mannosyltransferase LpcC Acts at transfer of mannose group to a 3-deoxy-D-mono octulonic acid (KDO) via an alpha-1%2C5 linkage. Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily%3B KEGG: clt:CM240_1092 UDP-D-galactose:(glucosyl)LPS alpha-1%2C6-D-galactosyltransferase%3B Hexosyltransferases gene gene1782 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01783 VSVS12_01784 VSVS12_01784 hasA hasA 1965348 1966529 + Hyaluronan synthase KEGG: sht:KO02_15915 hyaluronan synthase gene gene1783 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01784 VSVS12_01785 VSVS12_01785 VSVS12_01785 1966540 1967178 + Undecaprenyl-phosphate glucose phosphotransferase Involved in the biosynthesis of the exopolysaccharide acetan%2C a water-soluble polysaccharide involved in production of bacterial cellulose (BC)%3B Belongs to the bacterial sugar transferase family gene gene1784 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01785 VSVS12_01786 VSVS12_01786 VSVS12_01786 1967392 1967468 + tRNA-Val tRNA gene1785 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01786 VSVS12_01787 VSVS12_01787 VSVS12_01787 1967850 1969175 + uncharacterized protein Contains 1 GGDEF domain%3B Contains 1 PAC (PAS-associated C-terminal) domain%3B Contains 2 PAS (PER-ARNT-SIM) domains%3B KEGG: vfi:VF_A0343 null%3B Phosphotransferases with a nitrogenous group as acceptor gene gene1786 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01787 VSVS12_01788 VSVS12_01788 VSVS12_01788 1969344 1969583 + Serine/arginine-rich splicing factor Splicing factor that seems to antagonize SR proteins in pre-mRNA splicing regulation%3B Belongs to the splicing factor SR family%3B Contains 1 RRM (RNA recognition motif) domain gene gene1787 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01788 VSVS12_01789 VSVS12_01789 VSVS12_01789 1969677 1970609 - Glucokinase Transcriptional repressor of xylose-utilizing enzymes%3B Belongs to the ROK (NagC/XylR) family%3B KEGG: lsa:LSA0123 glucokinase gene gene1788 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01789 VSVS12_01790 VSVS12_01790 VSVS12_01790 1970982 1973468 + Phytochrome-like protein cph2 Photoreceptor which exists in two forms that are reversibly interconvertible by light: the R form that absorbs maximally in the red region of the spectrum and the FR form that absorbs maximally in the far-red region. Belongs to the phytochrome family%3B Contains 1 EAL domain%3B Contains 2 GAF domains%3B Contains 2 GGDEF domains%3B KEGG: dar:Daro_0244 null%3B Phosphotransferases with a nitrogenous group as acceptor gene gene1789 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01790 VSVS12_01791 VSVS12_01791 VSVS12_01791 1973750 1974958 + hypothetical protein gene gene1790 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01791 VSVS12_01792 VSVS12_01792 VSVS12_01792 1975061 1976368 + hypothetical protein gene gene1791 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01792 VSVS12_01793 VSVS12_01793 VSVS12_01793 1976597 1977637 + Cyclic di-GMP phosphodiesterase Gmr Part of a 2 protein system that seems to be dedicated to transcription of csgD. This protein decreases csgD transcription and thus decreases expression of adhesive curli fimbriae genes csgEFG%2C csgBAC/ymaD and adrA (yaic). Activity of this protein is antagonized by the diguanylate cyclase YdaM. In vitro has c-di-GMP phosphodiesterase activity. Cyclic-di-GMP is a second messenger which controls cell surface-associated traits in bacteria%3B Contains 1 EAL domain%3B Contains 1 GGDEF domain%3B Contains 1 PAS (PER-ARNT-SIM) domain gene gene1792 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01793 VSVS12_01794 VSVS12_01794 VSVS12_01794 1977685 1978341 - hypothetical protein gene gene1793 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01794 VSVS12_01795 VSVS12_01795 VSVS12_01795 1978586 1979317 + Spermidine/putrescine import ATP-binding protein PotA Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system%3B Belongs to the ABC transporter superfamily. Spermidine/putrescine importer (TC 3. A. 1. 11. 1) family%3B Contains 1 ABC transporter domain gene gene1794 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01795 VSVS12_01796 VSVS12_01796 VSVS12_01796 1979318 1980115 + Putative amino-acid ABC transporter permease protein Probably part of the binding-protein-dependent transport system YdhWXYZ for an amino aci%3B probably responsible for the translocation of the substrate across the membrane. Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily%3B Contains 1 ABC transmembrane type-1 domain gene gene1795 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01796 VSVS12_01797 VSVS12_01797 VSVS12_01797 1980125 1980952 + putative ABC transporter arginine-binding protein ArtJ Probably part of an ABC transporter complex involved in arginine transport. Binds arginine. Interacts with host epithelial cells%2C suggesting a role in host-cell adhesion during infection%3B Belongs to the bacterial solute-binding protein 3 family gene gene1796 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01797 VSVS12_01798 VSVS12_01798 VSVS12_01798 1981040 1981957 + Glutamate/aspartate transport system permease protein GltJ Part of the binding-protein-dependent transport system for aspartate/glutamat%3B probably responsible for the translocation of the substrate across the membrane%3B Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily%3B Contains 1 ABC transmembrane type-1 domain gene gene1797 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01798 VSVS12_01799 VSVS12_01799 VSVS12_01799 1982046 1983245 - hypothetical protein gene gene1798 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01799 VSVS12_01800 VSVS12_01800 VSVS12_01800 1983242 1983862 - Protein tonB2 Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane%2C resulting in the release into the periplasm of ligands bound by these outer membrane proteins (By similarity)%3B Belongs to the TonB family gene gene1799 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01800 VSVS12_01801 VSVS12_01801 VSVS12_01801 1983862 1984266 - Biopolymer transport protein exbD2 Involved in the TonB-dependent energy-dependent transport of various receptor-bound substrates%3B Belongs to the ExbD/TolR family gene gene1800 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01801 VSVS12_01802 VSVS12_01802 VSVS12_01802 1984263 1984823 - hypothetical protein gene gene1801 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01802 VSVS12_01803 VSVS12_01803 VSVS12_01803 1984823 1986184 - Putative biopolymer transport protein ExbB-like Involved in the TonB-dependent energy-dependent transport of various receptor-bound substrates. Protects ExbD from proteolytic degradation and functionally stabilizes TonB (By similarity)%3B Belongs to the ExbB/TolQ family gene gene1802 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01803 VSVS12_01804 VSVS12_01804 VSVS12_01804 1986184 1986945 - hypothetical protein gene gene1803 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01804 VSVS12_01805 VSVS12_01805 VSVS12_01805 1987165 1989273 - Pesticin receptor Receptor for the bacteriocin pesticin and for the siderophore yersiniabactin%3B Belongs to the TonB-dependent receptor family gene gene1804 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01805 VSVS12_01806 VSVS12_01806 cpxA cpxA 1989749 1991122 - Histidine kinase Member of the two-component regulatory system ArlS/ArlR involved in the regulation of adhesion%2C autolysis%2C multidrug resistance and virulence. ArlS probably functions as a sensor protein kinase which is autophosphorylated at a histidine residue and transfers its phosphate group to ArlR (By similarity)%3B Contains 1 HAMP domain%3B Contains 1 histidine kinase domain%3B KEGG: llo:LLO_1782 two-component system%2C OmpR family%2C sensor histidine kinase CpxA gene gene1805 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01806 VSVS12_01807 VSVS12_01807 VSVS12_01807 1991126 1991791 - Response regulator ArlR Member of the two-component regulatory system ArlS/ArlR%3B Contains 1 OmpR/PhoB-type DNA-binding domain%3B Contains 1 response regulatory domain gene gene1806 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01807 VSVS12_01808 VSVS12_01808 VSVS12_01808 1991962 1994553 - Putative TRAP transporter large permease protein Belongs to the TRAP transporter large permease family gene gene1807 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01808 VSVS12_01809 VSVS12_01809 VSVS12_01809 1994703 1995674 - 31 kDa immunogenic protein gene gene1808 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01809 VSVS12_01810 VSVS12_01810 glpQ glpQ 1996316 1997035 + Glycerophosphodiester phosphodiesterase Belongs to the glycerophosphoryl diester phosphodiesterase family%3B Contains 1 GP-PDE domain%3B KEGG: slg:SLGD_01210 glycerophosphoryl diester phosphodiesterase gene gene1809 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01810 VSVS12_01811 VSVS12_01811 VSVS12_01811 1997279 1997674 + hypothetical protein gene gene1810 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01811 VSVS12_01812 VSVS12_01812 purC purC 1997941 1999044 + Phosphoribosylaminoimidazolesuccinocarboxamide synthase Belongs to the SAICAR synthetase family%3B KEGG: vch:VC1190 phosphoribosylaminoimidazole-succinocarboxamide synthase gene gene1811 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01812 VSVS12_01813 VSVS12_01813 VSVS12_01813 1999265 2000173 + HTH-type transcriptional regulator YidZ Involved in anaerobic NO protection%3B Contains 1 HTH lysR-type DNA-binding domain gene gene1812 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01813 VSVS12_01814 VSVS12_01814 VSVS12_01814 2000282 2001178 - [Formate-C-acetyltransferase]-activating enzyme Belongs to the organic radical-activating enzymes family%3B Contains 2 4Fe-4S ferredoxin-type domains%3B KEGG: vfi:VF_A0962 pyruvate formate lyase activating enzyme gene gene1813 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01814 VSVS12_01815 VSVS12_01815 VSVS12_01815 2001184 2002725 - uncharacterized protein To H. influenzae HI_0521 gene gene1814 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01815 VSVS12_01816 VSVS12_01816 VSVS12_01816 2002904 2004787 - Methyl-accepting chemotaxis protein PctA Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment%2C transduce a signal from the outside to the inside of the cell%2C and facilitate sensory adaptation through the variation of the level of methylation. Major receptor that responds to all naturally occurring L-amino acids%2C except L-Gln and L-Asp. Also involved in repellent responses to trichloroethylene (TCE)%2C chloroform and methylthiocyanate%3B Contains 1 cache domain%3B Contains 1 HAMP domain%3B Contains 1 methyl-accepting transducer domain gene gene1815 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01816 VSVS12_01817 VSVS12_01817 VSVS12_01817 2005038 2005292 - hypothetical protein gene gene1816 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01817 VSVS12_01818 VSVS12_01818 VSVS12_01818 2005361 2006038 - Leucine efflux protein Exporter of leucine%3B Belongs to the rht family gene gene1817 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01818 VSVS12_01819 VSVS12_01819 gyrA gyrA 2006277 2008937 - DNA topoisomerase (ATP-hydrolyzing) DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings%2C including catenanes and knotted rings%3B Belongs to the topoisomerase GyrA/ParC subunit family%3B KEGG: eco:b2231 DNA gyrase subunit A gene gene1818 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01819 VSVS12_01820 VSVS12_01820 ubiG ubiG 2009148 2009930 + 2-polyprenyl-6-hydroxyphenol methylase O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway%3B Belongs to the methyltransferase superfamily. UbiG/COQ3 family%3B KEGG: vvu:VV1_3040 2-polyprenyl-6-hydroxyphenyl methylase / 3-demethylubiquinone-9 3-methyltransferase gene gene1819 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01820 VSVS12_01821 VSVS12_01821 nrdA nrdA 2010382 2012664 + Ribonucleoside-diphosphate reductase Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. R1 contains the binding sites for both substrates and allosteric effectors and carries out the actual reduction of the ribonucleotide. It also provides redox- active cysteines. Belongs to the ribonucleoside diphosphate reductase large chain family%3B Contains 1 ATP-cone domain%3B KEGG: eco:b2234 ribonucleoside-diphosphate reductase alpha chain gene gene1820 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01821 VSVS12_01822 VSVS12_01822 nrdB nrdB 2012752 2013885 + Ribonucleoside-diphosphate reductase Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. R2 contains the tyrosyl radical required for catalysis. Belongs to the ribonucleoside diphosphate reductase small chain family%3B KEGG: eclx:LI66_15175 ribonucleoside-diphosphate reductase beta chain gene gene1821 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01822 VSVS12_01823 VSVS12_01823 VSVS12_01823 2013885 2014163 + putative ferredoxin-like protein YfaE Contains 1 2Fe-2S ferredoxin-type domain gene gene1822 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01823 VSVS12_01824 VSVS12_01824 VSVS12_01824 2014291 2014539 - hypothetical protein gene gene1823 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01824 VSVS12_01825 VSVS12_01825 pncC pncC 2014724 2015971 - Nicotinamide-nucleotide amidase Belongs to the CinA family%3B KEGG: clo:HMPREF0868_0630 nicotinamide-nucleotide amidase gene gene1824 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01825 VSVS12_01826 VSVS12_01826 VSVS12_01826 2016149 2017042 + hypothetical protein gene gene1825 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01826 VSVS12_01827 VSVS12_01827 VSVS12_01827 2017269 2017781 + hypothetical protein gene gene1826 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01827 VSVS12_01828 VSVS12_01828 nspC nspC 2017839 2018972 - Carboxynorspermidine decarboxylase Catalyzes the decarboxylation of carboxynorspermidine and carboxyspermidine. 2%2C3-diaminopropionic acid%2C 2%2C4- diaminobutyric acid%2C L-ornithine or L-lysine can not serve as substrates%3B Belongs to the Orn/Lys/Arg decarboxylase class-II family. NspC subfamily%3B KEGG: vag:N646_1022 carboxynorspermidine decarboxylase gene gene1827 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01828 VSVS12_01829 VSVS12_01829 VSVS12_01829 2020016 2021260 - Carboxynorspermidine synthase Required for norspermidine biosynthesis and for biofilm formation%3B Belongs to the saccharopine dehydrogenase family. carboxynorspermidine synthase subfamily%3B KEGG: vch:VC1624 carboxynorspermidine synthase gene gene1828 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01829 VSVS12_01830 VSVS12_01830 ectB ectB 2021270 2024182 - Diaminobutyrate--2-oxoglutarate transaminase Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family%3B KEGG: vvu:VV1_3050 diaminobutyrate-2-oxoglutarate transaminase gene gene1829 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01830 VSVS12_01831 VSVS12_01831 VSVS12_01831 2024854 2026167 + Outer membrane efflux protein BepC Involved in the efflux of toxic and relatively hydrophobic compounds. Influences survival inside the host%3B Belongs to the outer membrane factor (OMF) (TC 1. B. 17) family gene gene1830 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01831 VSVS12_01832 VSVS12_01832 VSVS12_01832 2026167 2026790 + Outer membrane protein P.III Belongs to the OmpA family%3B Contains 1 OmpA-like domain gene gene1831 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01832 VSVS12_01833 VSVS12_01833 VSVS12_01833 2026858 2028012 - Na(+)/H(+) antiporter NhaA Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons%3B Belongs to the NhaA Na(+)/H(+) (TC 2. A. 33) antiporter family gene gene1832 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01833 VSVS12_01834 VSVS12_01834 VSVS12_01834 2028321 2029439 - hypothetical protein gene gene1833 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01834 VSVS12_01835 VSVS12_01835 VSVS12_01835 2029440 2031893 - hypothetical protein gene gene1834 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01835 VSVS12_01836 VSVS12_01836 VSVS12_01836 2031874 2032545 - Lipoprotein-releasing system ATP-binding protein LolD Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins%2C from the inner membrane to the periplasmic chaperone%2C LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner%3B Belongs to the ABC transporter superfamily. Lipoprotein translocase (TC 3. A. 1. 125) family%3B Contains 1 ABC transporter domain gene gene1835 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01836 VSVS12_01837 VSVS12_01837 VSVS12_01837 2032668 2034038 - putative multidrug resistance protein NorM Multidrug efflux pump%3B Belongs to the multi antimicrobial extrusion (MATE) (TC 2. A. 66. 1) family gene gene1836 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01837 VSVS12_01838 VSVS12_01838 rfbB rfbB 2034182 2035606 + dTDP-glucose 4%2C6-dehydratase KEGG: hma:rrnAC2178 dTDP-glucose 4%2C6-dehydratase gene gene1837 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01838 VSVS12_01839 VSVS12_01839 VSVS12_01839 2035666 2037867 - Cyclic di-GMP phosphodiesterase PdeB Affects motility and biofilm formation%2C and is linked to the regulation of sulfate uptake and assimilation%3B Contains 1 EAL domain%3B Contains 1 GGDEF domain%3B Contains 1 PAS (PER-ARNT-SIM) domain gene gene1838 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01839 VSVS12_01840 VSVS12_01840 VSVS12_01840 2038050 2039435 - Putative sodium/proton-dependent alanine carrier protein YrbD Belongs to the sodium:alanine (SAF) symporter family gene gene1839 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01840 VSVS12_01841 VSVS12_01841 VSVS12_01841 2039552 2040760 + hypothetical protein gene gene1840 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01841 VSVS12_01842 VSVS12_01842 VSVS12_01842 2040757 2041026 + hypothetical protein gene gene1841 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01842 VSVS12_01843 VSVS12_01843 VSVS12_01843 2041360 2042025 + Glutathione transferase KEGG: pen:PSEEN1720 glutathione S-transferase gene gene1842 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01843 VSVS12_01844 VSVS12_01844 VSVS12_01844 2042104 2042826 - hypothetical protein gene gene1843 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01844 VSVS12_01845 VSVS12_01845 VSVS12_01845 2042823 2044031 - hypothetical protein gene gene1844 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01845 VSVS12_01846 VSVS12_01846 VSVS12_01846 2044135 2044404 - hypothetical protein gene gene1845 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01846 VSVS12_01847 VSVS12_01847 VSVS12_01847 2044673 2045338 - hypothetical protein gene gene1846 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01847 VSVS12_01848 VSVS12_01848 VSVS12_01848 2045338 2046540 - Multidrug resistance protein MdtL Belongs to the major facilitator superfamily. DHA1 family. MdtL (TC 2. A. 1. 2. 22) subfamily gene gene1847 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01848 VSVS12_01849 VSVS12_01849 VSVS12_01849 2046752 2047483 - 16S rRNA pseudouridine(516) synthase Responsible for synthesis of pseudouridine from uracil- 516 in 16S ribosomal RNA%3B Belongs to the pseudouridine synthase RsuA family%3B Contains 1 S4 RNA-binding domain%3B KEGG: son:SO_3583 16S rRNA pseudouridine516 synthase gene gene1848 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01849 VSVS12_01850 VSVS12_01850 VSVS12_01850 2047557 2049299 + uncharacterized protein Contains 1 helicase ATP-binding domain%3B Contains 1 helicase C-terminal domain%3B KEGG: eco:b2184 ATP-dependent helicase IRC3%3B Acting on ATP%3B involved in cellular and subcellular movement gene gene1849 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01850 VSVS12_01851 VSVS12_01851 VSVS12_01851 2049403 2049834 + hypothetical protein gene gene1850 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01851 VSVS12_01852 VSVS12_01852 VSVS12_01852 2049839 2050498 + Transcriptional regulatory protein Member of the two-component regulatory system BasS/BasR. BasR induces the transcription of the ugd%2C ais%2C arnBCADTEF and eptA-basRS loci%2C all involved in resistance to polymyxin (By similarity)%3B Contains 1 OmpR/PhoB-type DNA-binding domain%3B Contains 1 response regulatory domain gene gene1851 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01852 VSVS12_01853 VSVS12_01853 phoQ phoQ 2050488 2051828 + Histidine kinase Member of the two-component regulatory system PhoP/PhoQ involved in virulence%2C adaptation to low Mg(2+) environments and the control of acid resistance genes. In low periplasmic Mg(2+)%2C PhoQ functions as a membrane-associated protein kinase that undergoes autophosphorylation and subsequently transfers the phosphate to PhoP%2C resulting in the expression of PhoP-activated genes (PAG) and repression of PhoP-repressed genes (PRG). In high periplasmic Mg(2+)%2C acts as a protein phosphatase that dephosphorylates phospho-PhoP%2C which results in the repression of PG and may lead to expression of some PRG (By similarity)%3B Contains 1 HAMP domain%3B Contains 1 histidine kinase domain%3B KEGG: nit:NAL212_1248 two-component system%2C OmpR family%2C sensor histidine kinase PhoQ gene gene1852 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01853 VSVS12_01854 VSVS12_01854 VSVS12_01854 2051951 2053138 - Sugar efflux transporter Involved in the efflux of sugars. The physiological role may be the detoxification of non-metabolizable sugar analogs. Can transport lactose and glucose. Belongs to the major facilitator superfamily. Set transporter family gene gene1853 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01854 VSVS12_01855 VSVS12_01855 VSVS12_01855 2053331 2054218 + putative HTH-type transcriptional regulator YijO Contains 1 HTH araC/xylS-type DNA-binding domain gene gene1854 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01855 VSVS12_01856 VSVS12_01856 VSVS12_01856 2054271 2055569 - hypothetical protein gene gene1855 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01856 VSVS12_01857 VSVS12_01857 VSVS12_01857 2055589 2056323 - putative glycosyltransferase EpsJ May be involved in the production of the exopolysaccharide (EPS) component of the extracellular matrix during biofilm formation. EPS is responsible for the adhesion of chains of cells into bundles. Belongs to the glycosyltransferase 2 family%3B KEGG: vfi:VF_1399 null%3B Glycosyltransferases gene gene1856 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01857 VSVS12_01858 VSVS12_01858 VSVS12_01858 2056681 2056959 + 50S ribosomal protein L25 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance%3B Belongs to the ribosomal protein L25P family gene gene1857 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01858 VSVS12_01859 VSVS12_01859 VSVS12_01859 2057325 2057681 - hypothetical protein gene gene1858 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01859 VSVS12_01860 VSVS12_01860 VSVS12_01860 2057951 2058841 + Protein RarD Belongs to the EamA transporter family%3B Contains 1 EamA domain gene gene1859 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01860 VSVS12_01861 VSVS12_01861 VSVS12_01861 2058958 2059368 + hypothetical protein gene gene1860 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01861 VSVS12_01862 VSVS12_01862 VSVS12_01862 2059467 2060195 + Transposase InsF for insertion sequence IS3A Involved in the transposition of the insertion sequence IS3. Belongs to the transposase IS3/IS150/IS904 family%3B Contains 1 integrase catalytic domain gene gene1861 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01862 VSVS12_01863 VSVS12_01863 VSVS12_01863 2060294 2060515 - hypothetical protein gene gene1862 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01863 VSVS12_01864 VSVS12_01864 VSVS12_01864 2060861 2062648 + Diguanylate cyclase DosC Globin-coupled heme-based oxygen sensor protein displaying diguanylate cyclase (DGC) activity in response to oxygen availability. Thus%2C catalyzes the synthesis of cyclic diguanylate (c-di-GMP) via the condensation of 2 GTP molecules. Cyclic-di-GMP is a second messenger which controls cell surface- associated traits in bacteria (By similarity)%3B Contains 1 GGDEF domain gene gene1863 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01864 VSVS12_01865 VSVS12_01865 VSVS12_01865 2062611 2062748 - hypothetical protein gene gene1864 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01865 VSVS12_01866 VSVS12_01866 VSVS12_01866 2062748 2063224 - Nutrient stress-induced DNA-binding protein Involved in protection of chromosomal DNA from damage under nutrient-limited and oxidative stress conditions. Binds heme (By similarity)%3B Belongs to the Dps family gene gene1865 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01866 VSVS12_01867 VSVS12_01867 VSVS12_01867 2063404 2063751 - hypothetical protein gene gene1866 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01867 VSVS12_01868 VSVS12_01868 VSVS12_01868 2063948 2064946 + NTD biosynthesis operon regulator NtdR Positively regulates the ntdABC operon and negatively regulates its own transcription. Binds to NTD to induce ntdABC transcription%3B Contains 1 HTH lacI-type DNA-binding domain gene gene1867 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01868 VSVS12_01869 VSVS12_01869 VSVS12_01869 2065227 2065535 + Protein-N(pi)-phosphohistidine--sugar phosphotransferase The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS)%2C a major carbohydrate active -transport system%2C catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in cellobiose transport. Contains 1 PTS EIIB type-3 domain%3B KEGG: serr:Ser39006_2113 PTS system%2C cellobiose-specific IIB component gene gene1868 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01869 VSVS12_01870 VSVS12_01870 VSVS12_01870 2065556 2066896 + Cellobiose permease IIC component The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS)%2C a major carbohydrate active -transport system%2C catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. This system is involved in cellobiose transport. Contains 1 PTS EIIC type-3 domain gene gene1869 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01870 VSVS12_01871 VSVS12_01871 VSVS12_01871 2066880 2067296 + Protein-N(pi)-phosphohistidine--sugar phosphotransferase The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS)%2C a major carbohydrate active -transport system%2C catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. This system is involved in lactose transport (By similarity)%3B Contains 1 PTS EIIA type-3 domain%3B KEGG: ppr:PBPRA2778 PTS system%2C cellobiose-specific IIA component gene gene1870 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01871 VSVS12_01872 VSVS12_01872 VSVS12_01872 2067293 2068174 + hypothetical protein gene gene1871 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01872 VSVS12_01873 VSVS12_01873 VSVS12_01873 2068342 2068977 - Chemotaxis response regulator protein-glutamate methylesterase Involved in the modulation of the chemotaxis syste%3B catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR%3B Contains 1 cheB-type methylesterase domain%3B Contains 1 response regulatory domain gene gene1872 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01873 VSVS12_01874 VSVS12_01874 VSVS12_01874 2068970 2070325 - Histidine kinase Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment%2C transduce a signal from the outside to the inside of the cell%2C and facilitate sensory adaptation through the variation of the level of methylation. Chemoreceptor for malate%3B Contains 1 HAMP domain%3B Contains 1 methyl-accepting transducer domain%3B KEGG: vvu:VV1_2240 two-component system%2C NarL family%2C sensor kinase gene gene1873 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01874 VSVS12_01875 VSVS12_01875 VSVS12_01875 2070454 2071737 - Sialic acid TRAP transporter permease protein SiaT Part of the tripartite ATP-independent periplasmic (TRAP) transport system SiaPT involved in the uptake of sialic acid%3B In the N-terminal sectio%3B belongs to the TRAP transporter small permease family%3B In the C-terminal sectio%3B belongs to the TRAP transporter large permease family gene gene1874 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01875 VSVS12_01876 VSVS12_01876 VSVS12_01876 2071748 2072281 - hypothetical protein gene gene1875 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01876 VSVS12_01877 VSVS12_01877 VSVS12_01877 2072468 2073589 - Monocarboxylate 2-oxoacid-binding periplasmic protein Part of the tripartite ATP-independent periplasmic (TRAP) transport system involved in the uptake of monocarboxylate 2-oxoacids. This protein specifically binds monocarboxylate 2- oxoacids including pyruvate%2C 2-oxobutyrate%2C 2-oxovalerate%2C 2- oxoisovalerate%2C 2-oxoisocaproate and 2-oxo-3-methylvalerate. Is not able to bind mannitol%3B Belongs to the bacterial solute-binding protein 7 family gene gene1876 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01877 VSVS12_01878 VSVS12_01878 VSVS12_01878 2073966 2074352 - hypothetical protein gene gene1877 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01878 VSVS12_01879 VSVS12_01879 VSVS12_01879 2074589 2075329 + hypothetical protein gene gene1878 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01879 VSVS12_01880 VSVS12_01880 VSVS12_01880 2075447 2076103 - Hydroxyacylglutathione hydrolase Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family%3B KEGG: pha:PSHAa1401 hydroxyacylglutathione hydrolase gene gene1879 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01880 VSVS12_01881 VSVS12_01881 VSVS12_01881 2076189 2076686 - uncharacterized protein To H. influenzae HI_1666 gene gene1880 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01881 VSVS12_01882 VSVS12_01882 VSVS12_01882 2076941 2078479 - putative L%2CD-transpeptidase YcbB Responsible%2C at least in part%2C for generating a meso- diaminopimelyl-3-a meso-diaminopimelyl-3 cross-link%3B Belongs to the YkuD family gene gene1881 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01882 VSVS12_01883 VSVS12_01883 VSVS12_01883 2078591 2079676 - hypothetical protein gene gene1882 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01883 VSVS12_01884 VSVS12_01884 VSVS12_01884 2079666 2080703 - hypothetical protein gene gene1883 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01884 VSVS12_01885 VSVS12_01885 VSVS12_01885 2080715 2082109 - hypothetical protein gene gene1884 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01885 VSVS12_01886 VSVS12_01886 VSVS12_01886 2082235 2083497 - hypothetical protein gene gene1885 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01886 VSVS12_01887 VSVS12_01887 ribA ribA 2083688 2084335 - GTP cyclohydrolase II Catalyzes the conversion of GTP to 2%2C5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP)%2C formate and pyrophosphate%3B Belongs to the GTP cyclohydrolase II family%3B KEGG: vcy:IX92_05595 GTP cyclohydrolase II gene gene1886 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01887 VSVS12_01888 VSVS12_01888 VSVS12_01888 2084673 2084852 - hypothetical protein gene gene1887 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01888 VSVS12_01889 VSVS12_01889 VSVS12_01889 2085092 2085565 - hypothetical protein gene gene1888 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01889 VSVS12_01890 VSVS12_01890 VSVS12_01890 2085579 2086166 - HD domain-containing protein Belongs to the HDDC2 family%3B Contains 1 HD domain gene gene1889 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01890 VSVS12_01891 VSVS12_01891 VSVS12_01891 2086166 2086750 - Ribosomal-protein-alanine N-acetyltransferase This enzyme acetylates the N-terminal alanine of ribosomal protein S5. Plays also a role in the temperature regulation of pap pilin transcription (By similarity)%3B Belongs to the acetyltransferase family. RimJ subfamily%3B Contains 1 N-acetyltransferase domain%3B KEGG: vcy:IX92_05565 ribosomal-protein-alanine N-acetyltransferase gene gene1890 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01891 VSVS12_01892 VSVS12_01892 VSVS12_01892 2086750 2088294 - Transcriptional regulatory protein TyrR Involved in transcriptional regulation of aromatic amino acid biosynthesis and transport. Modulates the expression of at least 8 unlinked operons. Seven of these operons are regulated in response to changes in the concentration of the three aromatic amino acids (phenylalanine%2C tyrosine and tryptophan). These amino acids are suggested to act as co-effectors which bind to the TyrR protein to form an active regulatory protein. In most cases TyrR causes negative regulation%2C but positive effects on the tyrP gene have been observed at high phenylalanine concentrations (By similarity)%3B Contains 1 ACT domain%3B Contains 1 PAS (PER-ARNT-SIM) domain%3B Contains 1 sigma-54 factor interaction domain gene gene1891 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01892 VSVS12_01893 VSVS12_01893 VSVS12_01893 2088396 2089424 - UPF0283 membrane protein Belongs to the UPF0283 family gene gene1892 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01893 VSVS12_01894 VSVS12_01894 VSVS12_01894 2089421 2090797 - uncharacterized protein To H. influenzae HI_1637 gene gene1893 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01894 VSVS12_01895 VSVS12_01895 VSVS12_01895 2090948 2091133 - hypothetical protein gene gene1894 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01895 VSVS12_01896 VSVS12_01896 fumA fumA 2091317 2092837 - Fumarate hydratase Belongs to the class-I fumarase family%3B KEGG: xfa:XF1855 fumarate hydratase%2C class I gene gene1895 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01896 VSVS12_01897 VSVS12_01897 pabB pabB 2093016 2094398 + Aminodeoxychorismate synthase Part of a heterodimeric complex that catalyzes the two- step biosynthesis of 4-amino-4-deoxychorismate (ADC)%2C a precursor of p-aminobenzoate (PABA) and tetrahydrofolate. In the first step%2C a glutamine amidotransferase (PabA) generates ammonia as a substrate that%2C along with chorismate%2C is used in the second step%2C catalyzed by aminodeoxychorismate synthase (PabB) to produce ADC. PabB%2C in the absence of PabA%2C can catalyze the formation of ADC in the presence of exogenous ammonia%3B Belongs to the anthranilate synthase component I family%3B KEGG: vha:VIBHAR_01914 para-aminobenzoate synthetase component I gene gene1896 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01897 VSVS12_01898 VSVS12_01898 VSVS12_01898 2094496 2096199 - Signal transduction histidine-protein kinase Member of the two-component regulatory system UvrY/BarA involved in the regulation of carbon metabolism via the CsrA/CsrB regulatory system. Phosphorylates UvrY%2C probably via a four-step phosphorelay (By similarity)%3B Contains 1 HAMP domain%3B Contains 1 histidine kinase domain%3B Contains 1 HPt domain%3B Contains 1 response regulatory domain%3B KEGG: vfi:VF_A0072 null%3B Phosphotransferases with a nitrogenous group as acceptor gene gene1897 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01898 VSVS12_01899 VSVS12_01899 VSVS12_01899 2096196 2096738 - hypothetical protein gene gene1898 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01899 VSVS12_01900 VSVS12_01900 VSVS12_01900 2096901 2097509 + putative Nudix hydrolase NudL Probably mediates the hydrolysis of some nucleoside diphosphate derivatives%3B Belongs to the Nudix hydrolase family. PCD1 subfamily%3B Contains 1 nudix hydrolase domain%3B KEGG: phi:102113473 peroxisomal coenzyme A diphosphatase NUDT7%3B In phosphorus-containing anhydrides gene gene1899 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01900 VSVS12_01901 VSVS12_01901 VSVS12_01901 2097801 2099054 + Serine transporter Involved in the import of serine into the cell. May be required for phage C1 adsorption by interacting with DrcB. May also be involved in ampicillin sensitivity (By similarity)%3B Belongs to the amino acid/polyamine transporter 2 family. SdaC/TdcC subfamily gene gene1900 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01901 VSVS12_01902 VSVS12_01902 sdaA sdaA 2099146 2100507 + L-serine ammonia-lyase Deaminates also threonine%2C particularly when it is present in high concentration. Belongs to the iron-sulfur dependent L-serine dehydratase family%3B KEGG: eco:b1814 L-serine dehydratase gene gene1901 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01902 VSVS12_01903 VSVS12_01903 VSVS12_01903 2100668 2101132 + hypothetical protein gene gene1902 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01903 VSVS12_01904 VSVS12_01904 queD queD 2101230 2101592 - 6-pyruvoyltetrahydropterin synthase Catalyzes the conversion of 7%2C8-dihydroneopterin triphosphate (H2NTP) to 6-carboxy-5%2C6%2C7%2C8-tetrahydropterin (CPH4) and acetaldehyde%3B Belongs to the PTPS family. QueD subfamily%3B KEGG: vch:VC1299 6-pyruvoyltetrahydropterin/6-carboxytetrahydropterin synthase gene gene1903 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01904 VSVS12_01905 VSVS12_01905 VSVS12_01905 2101875 2103512 + Putative methyl-accepting chemotaxis protein Belongs to the phytochrome family%3B Contains 2 GAF domains%3B Contains 1 HAMP domain%3B Contains 1 methyl-accepting transducer domain gene gene1904 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01905 VSVS12_01906 VSVS12_01906 VSVS12_01906 2103711 2105066 + RING-type E3 ubiquitin transferase Contains 8 LRR (leucine-rich) repeats%3B KEGG: apla:101796642 E3 ubiquitin-protein ligase LRSAM1 gene gene1905 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01906 VSVS12_01907 VSVS12_01907 narS narS 2105379 2106824 + Asparagine--tRNA ligase Belongs to the class-II aminoacyl-tRNA synthetase family%3B KEGG: vco:VC0395_A0915 asparaginyl-tRNA synthetase gene gene1906 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01907 VSVS12_01908 VSVS12_01908 VSVS12_01908 2106973 2108166 + Transposase for insertion sequence element IS1001 Involved in the transposition of the insertion sequence. Belongs to the transposase 12 family gene gene1907 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01908 VSVS12_01909 VSVS12_01909 VSVS12_01909 2108379 2108609 + hypothetical protein gene gene1908 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01909 VSVS12_01910 VSVS12_01910 VSVS12_01910 2108782 2109081 + hypothetical protein gene gene1909 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01910 VSVS12_01911 VSVS12_01911 VSVS12_01911 2109169 2110161 - hypothetical protein gene gene1910 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01911 VSVS12_01912 VSVS12_01912 VSVS12_01912 2110136 2111344 - hypothetical protein gene gene1911 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01912 VSVS12_01913 VSVS12_01913 VSVS12_01913 2111404 2111979 - hypothetical protein gene gene1912 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01913 VSVS12_01914 VSVS12_01914 aspC aspC 2112356 2113546 + Aspartate transaminase Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family%3B KEGG: ype:YPO1410 aspartate aminotransferase gene gene1913 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01914 VSVS12_01915 VSVS12_01915 VSVS12_01915 2113636 2114277 - hypothetical protein gene gene1914 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01915 VSVS12_01916 VSVS12_01916 VSVS12_01916 2114523 2114921 - hypothetical protein gene gene1915 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01916 VSVS12_01917 VSVS12_01917 VSVS12_01917 2115125 2117059 - RNA helicase KEGG: ade:Adeh_0787 ATP-dependent helicase HrpB%3B overlaps another CDS with the same product name gene gene1916 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01917 VSVS12_01918 VSVS12_01918 VSVS12_01918 2117040 2117486 - RNA helicase May be involved in pre-mRNA splicing%3B Belongs to the DEAD box helicase family. DEAH subfamily. PRP22 sub-subfamily%3B Contains 1 helicase ATP-binding domain%3B Contains 1 helicase C-terminal domain%3B KEGG: drt:Dret_1053 ATP-dependent helicase HrpB%3B overlaps another CDS with the same product name gene gene1917 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01918 VSVS12_01919 VSVS12_01919 sfcA sfcA 2117684 2119372 + Malate dehydrogenase (oxaloacetate-decarboxylating) Belongs to the malic enzymes family%3B KEGG: vch:VC1188 malate dehydrogenase (oxaloacetate-decarboxylating) gene gene1918 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01919 VSVS12_01920 VSVS12_01920 VSVS12_01920 2119437 2119760 + hypothetical protein gene gene1919 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01920 VSVS12_01921 VSVS12_01921 VSVS12_01921 2119760 2120542 + hypothetical protein Participates in the barrier function of the cell envelope gene gene1920 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01921 VSVS12_01922 VSVS12_01922 VSVS12_01922 2120671 2121990 - uncharacterized protein Contains 1 GGDEF domain%3B Contains 1 PAC (PAS-associated C-terminal) domain%3B Contains 2 PAS (PER-ARNT-SIM) domains gene gene1921 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01922 VSVS12_01923 VSVS12_01923 VSVS12_01923 2122260 2123090 + hypothetical protein gene gene1922 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01923 VSVS12_01924 VSVS12_01924 csdA csdA 2123200 2124438 - putative cysteine desulfurase Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine%2C L-cystine%2C L-selenocysteine%2C and L- selenocystine to produce L-alanine%3B Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily%3B KEGG: psw:LK03_10895 cysteine sulfinate desulfinase%3B Carbon-sulfur lyases gene gene1923 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01924 VSVS12_01925 VSVS12_01925 VSVS12_01925 2124422 2125078 - hypothetical protein gene gene1924 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01925 VSVS12_01926 VSVS12_01926 trxB trxB 2125477 2126439 + Thioredoxin-disulfide reductase Thioredoxin reductase (TR) that exhibits both TR and thioredoxin (Trx) activities. Contains a C-terminal functional Trx domain. Functions as an electron donor for the plastidial 2-Cys peroxiredoxin BAS1 and participates in a NADPH-dependent hydrogen peroxide scavenging system in chloroplasts in the dark%3B Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family%3B Contains 1 thioredoxin domain%3B KEGG: vsp:VS_1186 thioredoxin reductase (NADPH) gene gene1925 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01926 VSVS12_01927 VSVS12_01927 VSVS12_01927 2126568 2128355 + ATP-binding/permease protein CydD Somehow involved in the cytochrome D branch of aerobic respiration. Seems to be a component of a transport system (By similarity)%3B Belongs to the ABC transporter superfamily. Cysteine exporter (TC 3. A. 1. 129. 1) family%3B Contains 1 ABC transmembrane type-1 domain%3B Contains 1 ABC transporter domain gene gene1926 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01927 VSVS12_01928 VSVS12_01928 VSVS12_01928 2128348 2130084 + ATP-binding/permease protein CydC Somehow involved in the cytochrome D branch of aerobic respiration. Seems to be a component of a transport system (By similarity)%3B Belongs to the ABC transporter superfamily. Cysteine exporter (TC 3. A. 1. 129. 1) family%3B Contains 1 ABC transmembrane type-1 domain%3B Contains 1 ABC transporter domain gene gene1927 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01928 VSVS12_01929 VSVS12_01929 VSVS12_01929 2130285 2130416 - hypothetical protein gene gene1928 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01929 VSVS12_01930 VSVS12_01930 VSVS12_01930 2130576 2131763 + Xaa-Pro dipeptidase Belongs to the peptidase M24 family%3B KEGG: bme:BMEI0485 Xaa-Pro dipeptidase gene gene1929 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01930 VSVS12_01931 VSVS12_01931 VSVS12_01931 2131801 2132313 + Transcriptional regulatory protein DoeX Acts as a transcriptional regulator%3B Contains 1 HTH asnC-type DNA-binding domain gene gene1930 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01931 VSVS12_01932 VSVS12_01932 doeC doeC 2132590 2134122 + Aldehyde dehydrogenase family 9 member A1-B Belongs to the aldehyde dehydrogenase family%3B KEGG: vag:N646_3798 aspartate-semialdehyde dehydrogenase%3B With NAD(+) or NADP(+) as acceptor gene gene1931 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01932 VSVS12_01933 VSVS12_01933 doeD doeD 2134281 2135696 + Diaminobutyrate--2-oxoglutarate transaminase Involved in the biosynthesis of ectoine ((S)-2-methyl- 1%2C4%2C5%2C6-tetrahydropyrimidine-4-carboxylic acid) which is a highly soluble organic osmolyte%2C called compatible solute%2C use to avoid excessive water efflux%2C plasmolysis%2C molecular crowding of the cytoplasm%2C and cessation of growth in high salinity environments. Catalyzes the conversion of L-2%2C4-diaminobutyrate (DABA) to L- aspartate beta-semialdehyde (ASA) by transamination with 2- oxoglutarate%3B Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family%3B KEGG: vag:N646_3797 L-2%2C4-diaminobutyrate transaminase%3B Transaminases gene gene1932 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01933 VSVS12_01934 VSVS12_01934 VSVS12_01934 2135767 2136246 - Peptide-methionine (S)-S-oxide reductase Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine%3B In the N-terminal sectio%3B belongs to the MsrA Met sulfoxide reductase family%3B In the C-terminal sectio%3B belongs to the MsrB Met sulfoxide reductase family%3B KEGG: mht:D648_18040 peptide methionine sulfoxide reductase msrA/msrB gene gene1933 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01934 VSVS12_01935 VSVS12_01935 VSVS12_01935 2136320 2137318 - hypothetical protein gene gene1934 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01935 VSVS12_01936 VSVS12_01936 nqo1 nqo1 2137488 2137814 - NAD(P)H dehydrogenase (quinone) KEGG: azo:azo1477 NAD(P)H dehydrogenase (quinone) gene gene1935 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01936 VSVS12_01937 VSVS12_01937 msrA msrA 2137804 2137911 - Peptide-methionine (S)-S-oxide reductase KEGG: vpb:VPBB_A0281 peptide-methionine (S)-S-oxide reductase gene gene1936 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01937 VSVS12_01938 VSVS12_01938 VSVS12_01938 2138030 2138575 - hypothetical protein gene gene1937 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01938 VSVS12_01939 VSVS12_01939 deaD deaD 2138791 2140077 + RNA helicase ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5. 8S rRNAs%3B Belongs to the DEAD box helicase family. DDX56/DBP9 subfamily%3B Contains 1 helicase ATP-binding domain%3B Contains 1 helicase C-terminal domain%3B KEGG: mvs:MVIS_3808 ATP-dependent RNA helicase DeaD gene gene1938 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01939 VSVS12_01940 VSVS12_01940 VSVS12_01940 2140192 2140776 - hypothetical protein gene gene1939 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01940 VSVS12_01941 VSVS12_01941 VSVS12_01941 2140802 2141152 - hypothetical protein gene gene1940 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01941 VSVS12_01942 VSVS12_01942 VSVS12_01942 2141378 2142475 + hypothetical protein gene gene1941 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01942 VSVS12_01943 VSVS12_01943 VSVS12_01943 2142662 2142904 + hypothetical protein gene gene1942 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01943 VSVS12_01944 VSVS12_01944 VSVS12_01944 2143021 2143515 + hypothetical protein gene gene1943 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01944 VSVS12_01945 VSVS12_01945 VSVS12_01945 2143870 2144397 - hypothetical protein gene gene1944 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01945 VSVS12_01946 VSVS12_01946 VSVS12_01946 2144611 2144949 - hypothetical protein gene gene1945 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01946 VSVS12_01947 VSVS12_01947 VSVS12_01947 2145245 2145811 - putative HTH-type transcriptional regulator YhgD Contains 1 HTH tetR-type DNA-binding domain gene gene1946 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01947 VSVS12_01948 VSVS12_01948 VSVS12_01948 2146124 2146630 + hypothetical protein gene gene1947 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01948 VSVS12_01949 VSVS12_01949 VSVS12_01949 2146987 2147925 + hypothetical protein gene gene1948 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01949 VSVS12_01950 VSVS12_01950 VSVS12_01950 2147883 2149091 - hypothetical protein gene gene1949 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01950 VSVS12_01951 VSVS12_01951 VSVS12_01951 2149330 2149428 + hypothetical protein gene gene1950 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01951 VSVS12_01952 VSVS12_01952 VSVS12_01952 2150303 2151811 - Putative transposase Contains 1 integrase catalytic domain gene gene1951 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01952 VSVS12_01953 VSVS12_01953 VSVS12_01953 2152316 2152696 + hypothetical protein gene gene1952 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01953 VSVS12_01954 VSVS12_01954 VSVS12_01954 2152800 2154008 + hypothetical protein gene gene1953 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01954 VSVS12_01955 VSVS12_01955 VSVS12_01955 2154005 2155171 + hypothetical protein gene gene1954 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01955 VSVS12_01956 VSVS12_01956 VSVS12_01956 2155585 2156049 + hypothetical protein gene gene1955 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01956 VSVS12_01957 VSVS12_01957 VSVS12_01957 2156334 2156993 + hypothetical protein gene gene1956 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01957 VSVS12_01958 VSVS12_01958 VSVS12_01958 2157151 2157774 + hypothetical protein gene gene1957 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01958 VSVS12_01959 VSVS12_01959 VSVS12_01959 2157841 2159109 - hypothetical protein gene gene1958 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01959 VSVS12_01960 VSVS12_01960 VSVS12_01960 2159167 2159739 - Protein LemA Belongs to the LemA family gene gene1959 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01960 VSVS12_01961 VSVS12_01961 VSVS12_01961 2159943 2160857 - hypothetical protein gene gene1960 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01961 VSVS12_01962 VSVS12_01962 VSVS12_01962 2160860 2161546 - hypothetical protein gene gene1961 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01962 VSVS12_01963 VSVS12_01963 VSVS12_01963 2161791 2162450 + hypothetical protein gene gene1962 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01963 VSVS12_01964 VSVS12_01964 VSVS12_01964 2162545 2163276 - hypothetical protein gene gene1963 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01964 VSVS12_01965 VSVS12_01965 VSVS12_01965 2163273 2165039 - hypothetical protein gene gene1964 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01965 VSVS12_01966 VSVS12_01966 VSVS12_01966 2165181 2166776 - putative transporter Belongs to the BCCT transporter (TC 2. A. 15) family gene gene1965 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01966 VSVS12_01967 VSVS12_01967 dpeP dpeP 2166896 2167930 - Membrane dipeptidase Belongs to the peptidase M19 family%3B KEGG: smaf:D781_3034 membrane dipeptidase gene gene1966 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01967 VSVS12_01968 VSVS12_01968 VSVS12_01968 2168009 2169499 - Aldehyde dehydrogenase (NAD(+)) Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate%3B Belongs to the aldehyde dehydrogenase family. AstD subfamily%3B KEGG: vha:VIBHAR_05501 aldehyde dehydrogenase (NAD+) gene gene1967 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01968 VSVS12_01969 VSVS12_01969 VSVS12_01969 2169626 2170042 - 2-iminobutanoate/2-iminopropanoate deaminase Plays a role in the maintenance of mitochondrial DNA%3B Belongs to the RutC family%3B KEGG: ari:UM93_14050 2-iminobutanoate/2-iminopropanoate deaminase gene gene1968 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01969 VSVS12_01970 VSVS12_01970 VSVS12_01970 2170209 2171084 + hypothetical protein gene gene1969 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01970 VSVS12_01971 VSVS12_01971 VSVS12_01971 2171206 2172243 + Choloylglycine hydrolase KEGG: vsp:VS_II0926 choloylglycine hydrolase gene gene1970 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01971 VSVS12_01972 VSVS12_01972 VSVS12_01972 2172387 2173274 - hypothetical protein gene gene1971 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01972 VSVS12_01973 VSVS12_01973 srmB srmB 2173523 2174803 - RNA helicase DEAD-box RNA helicase involved in the assembly of the 50S ribosomal subunit at low temperature. Exhibits RNA-stimulated ATP hydrolysis and RNA unwinding activity%3B Belongs to the DEAD box helicase family. SrmB subfamily%3B Contains 1 helicase ATP-binding domain%3B Contains 1 helicase C-terminal domain%3B KEGG: hin:HI0422 ATP-dependent RNA helicase SrmB gene gene1972 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01973 VSVS12_01974 VSVS12_01974 VSVS12_01974 2175069 2175389 - hypothetical protein gene gene1973 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01974 VSVS12_01975 VSVS12_01975 VSVS12_01975 2175379 2176407 - Toxin coregulated pilus biosynthesis protein May function as an environmental regulator of TCP biogenesis. Negatively regulates the synthesis of the major pilin subunit of TCP (TcpA). Contains 1 methyl-accepting transducer domain gene gene1974 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01975 VSVS12_01976 VSVS12_01976 VSVS12_01976 2176944 2177327 - hypothetical protein gene gene1975 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01976 VSVS12_01977 VSVS12_01977 VSVS12_01977 2177577 2177921 + Thiosulfate sulfurtransferase GlpE Catalyzes%2C although with low efficiency%2C the sulfur transfer reaction from thiosulfate to cyanide%3B Belongs to the GlpE family%3B Contains 1 rhodanese domain gene gene1976 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01977 VSVS12_01978 VSVS12_01978 VSVS12_01978 2178039 2178494 + hypothetical protein gene gene1977 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01978 VSVS12_01979 VSVS12_01979 VSVS12_01979 2178594 2179892 - Excitatory amino acid transporter Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium. Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2. A. 23) family. SLC1A2 subfamily gene gene1978 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01979 VSVS12_01980 VSVS12_01980 VSVS12_01980 2180018 2181250 - NADH dehydrogenase Transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Does not couple the redox reaction to proton translocation. Belongs to the NADH dehydrogenase family%3B KEGG: eco:b1109 NADH dehydrogenase gene gene1979 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01980 VSVS12_01981 VSVS12_01981 VSVS12_01981 2181715 2182296 + hypothetical protein gene gene1980 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01981 VSVS12_01982 VSVS12_01982 VSVS12_01982 2182576 2182977 + hypothetical protein gene gene1981 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01982 VSVS12_01983 VSVS12_01983 VSVS12_01983 2183005 2183703 - Histidine utilization repressor Repressor which binds to the hutP region in the histidine utilization (hut) operon. It blocks the expression of all the hut genes in the absence of inducer. Contains 1 HTH gntR-type DNA-binding domain gene gene1982 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01983 VSVS12_01984 VSVS12_01984 VSVS12_01984 2184098 2186095 + Toxin coregulated pilus biosynthesis protein May function as an environmental regulator of TCP biogenesis. Negatively regulates the synthesis of the major pilin subunit of TCP (TcpA). Contains 1 methyl-accepting transducer domain gene gene1983 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01984 VSVS12_01985 VSVS12_01985 VSVS12_01985 2186178 2186792 - Galactoside O-acetyltransferase Belongs to the transferase hexapeptide repeat family%3B KEGG: vvy:VVA0614 galactoside O-acetyltransferase gene gene1984 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01985 VSVS12_01986 VSVS12_01986 VSVS12_01986 2186900 2187460 - Ribosomal-protein-alanine N-acetyltransferase Catalyzes the transfer of an acetyl group from acetyl coenzyme A (AcCoA) to an acceptor substrate and releases both CoA and the acetylated product. It prefers the peptide Asp-Phe methyl ester (or aspartame) and the peptide antibiotics polymyxin B and colistin. Other substrates like dopamine%2C serotonin%2C puromycin%2C chloramphenicol%2C D-glucosamine%2C glycine and N-alpha-acetyl-L- glutamine are used and displayed lower activity%3B Contains 1 N-acetyltransferase domain%3B KEGG: pat:Patl_0113 ribosomal-protein-alanine N-acetyltransferase gene gene1985 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01986 VSVS12_01987 VSVS12_01987 VSVS12_01987 2187757 2188116 - hypothetical protein gene gene1986 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01987 VSVS12_01988 VSVS12_01988 VSVS12_01988 2188281 2189222 - HTH-type transcriptional regulator CzcR Contains 1 HTH lysR-type DNA-binding domain gene gene1987 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01988 VSVS12_01989 VSVS12_01989 VSVS12_01989 2189356 2190696 + putative multidrug resistance protein NorM Multidrug efflux pump%3B Belongs to the multi antimicrobial extrusion (MATE) (TC 2. A. 66. 1) family gene gene1988 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01989 VSVS12_01990 VSVS12_01990 VSVS12_01990 2190707 2191096 + hypothetical protein gene gene1989 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01990 VSVS12_01991 VSVS12_01991 VSVS12_01991 2191200 2192408 + hypothetical protein gene gene1990 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01991 VSVS12_01992 VSVS12_01992 VSVS12_01992 2192405 2192518 + hypothetical protein gene gene1991 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01992 VSVS12_01993 VSVS12_01993 VSVS12_01993 2192676 2193350 - hypothetical protein gene gene1992 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01993 VSVS12_01994 VSVS12_01994 pheT pheT 2193663 2196068 - Phenylalanine--tRNA ligase Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily%3B Contains 1 B5 domain%3B Contains 1 FDX-ACB domain%3B Contains 1 tRNA-binding domain%3B KEGG: eco:b1713 phenylalanyl-tRNA synthetase beta chain gene gene1993 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01994 VSVS12_01995 VSVS12_01995 pheS pheS 2196087 2197070 - Phenylalanine--tRNA ligase Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily%3B KEGG: hdu:HD1484 phenylalanyl-tRNA synthetase alpha chain gene gene1994 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01995 VSVS12_01996 VSVS12_01996 VSVS12_01996 2197179 2197286 - hypothetical protein gene gene1995 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01996 VSVS12_01997 VSVS12_01997 yjgM yjgM 2197322 2197804 + putative N-acetyltransferase camello Plays a role in regulation of gastrulation%2C possibly by controlled reduction of cell adhesion in the periblastopore region which is necessary for optimal cell motility%3B Belongs to the camello family%3B Contains 1 N-acetyltransferase domain%3B KEGG: vch:VC1217 putative acetyltransferase%3B Transferring groups other than amino-acyl groups gene gene1996 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01997 VSVS12_01998 VSVS12_01998 VSVS12_01998 2197850 2198965 - putative signaling protein Contains 1 EAL domain%3B Contains 1 GGDEF domain%3B Contains 1 MHYT domain gene gene1997 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01998 VSVS12_01999 VSVS12_01999 VSVS12_01999 2199141 2200328 - hypothetical protein gene gene1998 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_01999 VSVS12_02000 VSVS12_02000 VSVS12_02000 2200337 2201152 - uncharacterized protein gene gene1999 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02000 VSVS12_02001 VSVS12_02001 VSVS12_02001 2201188 2203551 - Putative membrane protein Belongs to the resistance-nodulation-cell division (RND) (TC 2. A. 6) family. MmpL subfamily gene gene2000 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02001 VSVS12_02002 VSVS12_02002 VSVS12_02002 2203736 2204524 - hypothetical protein gene gene2001 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02002 VSVS12_02003 VSVS12_02003 VSVS12_02003 2204870 2206375 - Diguanylate cyclase DosC Globin-coupled heme-based oxygen sensor protein displaying diguanylate cyclase (DGC) activity in response to oxygen availability. Thus%2C catalyzes the synthesis of cyclic diguanylate (c-di-GMP) via the condensation of 2 GTP molecules. Cyclic-di-GMP is a second messenger which controls cell surface- associated traits in bacteria (By similarity)%3B Contains 1 GGDEF domain gene gene2002 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02003 VSVS12_02004 VSVS12_02004 VSVS12_02004 2206405 2206929 - hypothetical protein gene gene2003 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02004 VSVS12_02005 VSVS12_02005 VSVS12_02005 2207273 2207348 - tRNA-Gly tRNA gene2004 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02005 VSVS12_02006 VSVS12_02006 VSVS12_02006 2207376 2207462 - tRNA-Leu tRNA gene2005 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02006 VSVS12_02007 VSVS12_02007 VSVS12_02007 2207549 2207624 - tRNA-Gly tRNA gene2006 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02007 VSVS12_02008 VSVS12_02008 VSVS12_02008 2207662 2207735 - tRNA-Cys tRNA gene2007 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02008 VSVS12_02009 VSVS12_02009 pgsA pgsA 2207976 2208533 - CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase This protein catalyzes the committed step to the synthesis of the acidic phospholipids%3B Belongs to the CDP-alcohol phosphatidyltransferase class-I family%3B KEGG: vch:VC1215 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase gene gene2008 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02009 VSVS12_02010 VSVS12_02010 VSVS12_02010 2208609 2210441 - UvrABC system protein The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision%3B Belongs to the UvrC family%3B Contains 1 GIY-YIG domain%3B Contains 1 UVR domain gene gene2009 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02010 VSVS12_02011 VSVS12_02011 VSVS12_02011 2210441 2211085 - Transcriptional regulatory protein DesR Member of the two-component regulatory system DesR/DesK%2C responsible for cold induction of the des gene coding for the Delta5 acyl-lipid desaturase%3B Contains 1 HTH luxR-type DNA-binding domain%3B Contains 1 response regulatory domain gene gene2010 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02011 VSVS12_02012 VSVS12_02012 VSVS12_02012 2211451 2211936 + hypothetical protein gene gene2011 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02012 VSVS12_02013 VSVS12_02013 VSVS12_02013 2212102 2213955 + hypothetical protein gene gene2012 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02013 VSVS12_02014 VSVS12_02014 dpo2 dpo2 2214144 2216507 + DNA-directed DNA polymerase Thought to be involved in DNA repair and/or mutagenesis. Belongs to the DNA polymerase type-B family%3B KEGG: spe:Spro_0731 DNA polymerase II gene gene2013 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02014 VSVS12_02015 VSVS12_02015 VSVS12_02015 2216493 2218541 - N%2CN'-diacetylchitobiose permease IIC component The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS)%2C a major carbohydrate active -transport system%2C catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. This system is involved in N%2CN'-diacetylchitobiose transport%3B Contains 1 PTS EIIC type-3 domain gene gene2014 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02015 VSVS12_02016 VSVS12_02016 VSVS12_02016 2218763 2219530 - hypothetical protein gene gene2015 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02016 VSVS12_02017 VSVS12_02017 VSVS12_02017 2219709 2220275 + Elongation factor P-like protein Belongs to the elongation factor P family gene gene2016 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02017 VSVS12_02018 VSVS12_02018 VSVS12_02018 2220278 2220598 + UPF0263 protein Belongs to the UPF0263 family gene gene2017 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02018 VSVS12_02019 VSVS12_02019 VSVS12_02019 2220736 2221032 - Integration host factor subunit alpha This protein is one of the two subunits of integration host factor%2C a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control%3B Belongs to the bacterial histone-like protein family gene gene2018 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02019 VSVS12_02020 VSVS12_02020 luxN luxN 2221736 2224237 + Autoinducer 1 sensor kinase/phosphatase LuxN At low cell density%2C in the absence of AI-1 (autoinducer 1)%2C LuxN has a kinase activity and autophosphorylates on His-471. The phosphoryl group is then transferred on Asp-771 of the response regulator domain. The phosphoryl group is transferred to LuxU%2C and ultimately to LuxO. At high cell density%2C in the presence of AI-1%2C the kinase activity is inactivated%2C and the response regulator domain has a phosphatase activity. LuxN phosphatase acts on itself. As LuxU could function to establish an equilibrium between the aspartyl-phosphate of LuxN and the aspartyl-phosphate of LuxO%2C LuxU transfers phosphate from LuxO to LuxN and finally phosphate is drained from the system%3B Contains 1 histidine kinase domain%3B Contains 1 response regulatory domain%3B KEGG: vcy:IX92_09305 two-component system%2C autoinducer 1 sensor kinase/phosphatase LuxN%3B Histidine kinase gene gene2019 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02020 VSVS12_02021 VSVS12_02021 VSVS12_02021 2224440 2224667 + hypothetical protein gene gene2020 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02021 VSVS12_02022 VSVS12_02022 VSVS12_02022 2224783 2225328 + putative intracellular septation protein Involved in cell divisio%3B probably involved in intracellular septation%3B Belongs to the YciB family gene gene2021 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02022 VSVS12_02023 VSVS12_02023 yciA yciA 2225489 2225884 + Acyl-CoA thioester hydrolase YciA Catalyzes the hydrolysis of the thioester bond in palmitoyl-CoA and malonyl-CoA%3B Belongs to the acyl coenzyme A hydrolase family%3B Contains 1 HotDog ACOT-type domain%3B KEGG: eam:EAMY_1926 acyl-CoA thioesterase YciA%3B Thiolester hydrolases gene gene2022 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02023 VSVS12_02024 VSVS12_02024 VSVS12_02024 2225997 2226293 + uncharacterized protein Belongs to the YciI family gene gene2023 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02024 VSVS12_02025 VSVS12_02025 VSVS12_02025 2226296 2226688 + hypothetical protein gene gene2024 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02025 VSVS12_02026 VSVS12_02026 VSVS12_02026 2226772 2226885 - hypothetical protein gene gene2025 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02026 VSVS12_02027 VSVS12_02027 VSVS12_02027 2227141 2227362 + hypothetical protein gene gene2026 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02027 VSVS12_02028 VSVS12_02028 VSVS12_02028 2227428 2227685 - uncharacterized protein gene gene2027 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02028 VSVS12_02029 VSVS12_02029 VSVS12_02029 2227838 2228281 + hypothetical protein gene gene2028 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02029 VSVS12_02030 VSVS12_02030 VSVS12_02030 2228629 2229771 + Protein YnjB gene gene2029 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02030 VSVS12_02031 VSVS12_02031 VSVS12_02031 2229812 2231512 + Inner membrane ABC transporter permease protein Probably part of the binding-protein-dependent transport system YnjCD. Probably responsible for the translocation of the substrate across the membrane. Belongs to the binding-protein-dependent transport system permease family%3B Contains 2 ABC transmembrane type-1 domains gene gene2030 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02031 VSVS12_02032 VSVS12_02032 VSVS12_02032 2231478 2232146 + Spermidine/putrescine import ATP-binding protein Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system%3B Belongs to the ABC transporter superfamily. Spermidine/putrescine importer (TC 3. A. 1. 11. 1) family%3B Contains 1 ABC transporter domain gene gene2031 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02032 VSVS12_02033 VSVS12_02033 VSVS12_02033 2232149 2232757 + CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase Belongs to the CDP-alcohol phosphatidyltransferase class-I family%3B KEGG: vfi:VF_A0094 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase gene gene2032 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02033 VSVS12_02034 VSVS12_02034 VSVS12_02034 2232960 2233829 + hypothetical protein gene gene2033 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02034 VSVS12_02035 VSVS12_02035 VSVS12_02035 2233856 2234791 - 23S rRNA (cytosine(1962)-C(5))-methyltransferase Specifically methylates the cytosine at position 1962 (m5C1962) of 23S rRNA%3B Belongs to the methyltransferase superfamily. RlmI family%3B Contains 1 PUA domain%3B KEGG: vcy:IX92_09375 23S rRNA (cytosine1962-C5)-methyltransferase gene gene2034 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02035 VSVS12_02036 VSVS12_02036 VSVS12_02036 2234800 2235495 - tRNA pseudouridine(32) synthase Belongs to the pseudouridine synthase RluA family%3B KEGG: vsp:VS_1978 tRNA pseudouridine32 synthase / 23S rRNA pseudouridine746 synthase gene gene2035 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02036 VSVS12_02037 VSVS12_02037 VSVS12_02037 2235615 2237231 - Methyl-accepting chemotaxis protein Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment%2C transduce a signal from the outside to the inside of the cell%2C and facilitate sensory adaptation through the variation of the level of methylation. Chemoreceptor for malate%3B Contains 1 HAMP domain%3B Contains 1 methyl-accepting transducer domain gene gene2036 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02037 VSVS12_02038 VSVS12_02038 VSVS12_02038 2237406 2238701 - putative sodium-dependent transporter YhdH Putative sodium-dependent transporter%3B Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2. A. 22) family gene gene2037 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02038 VSVS12_02039 VSVS12_02039 VSVS12_02039 2239139 2240593 + Cardiolipin synthase Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol%3B Belongs to the phospholipase D family. Cardiolipin synthase subfamily. ClsA sub-subfamily%3B Contains 2 PLD phosphodiesterase domains%3B KEGG: vvu:VV1_2871 cardiolipin synthase%3B Transferases for other substituted phosphate groups gene gene2038 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02039 VSVS12_02040 VSVS12_02040 VSVS12_02040 2240740 2241771 + Cystathionine beta-lyase Belongs to the trans-sulfuration enzymes family%3B KEGG: vtu:IX91_06075 cystathionine beta-lyase%3B overlaps another CDS with the same product name gene gene2039 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02040 VSVS12_02041 VSVS12_02041 VSVS12_02041 2241744 2241944 + Cystathionine beta-lyase Belongs to the trans-sulfuration enzymes family%3B KEGG: eco:b3008 cystathionine beta-lyase%3B overlaps another CDS with the same product name gene gene2040 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02041 VSVS12_02042 VSVS12_02042 VSVS12_02042 2242056 2242631 - DNA-3-methyladenine glycosylase I Catalyzes the synthesis of GMP from XMP%3B Contains 1 glutamine amidotransferase type-1 domain%3B Contains 1 GMPS ATP-PPase (ATP pyrophosphatase) domain%3B Contains 3 N-acetyltransferase domains%3B KEGG: vha:VIBHAR_01878 DNA-3-methyladenine glycosylase I gene gene2041 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02042 VSVS12_02043 VSVS12_02043 VSVS12_02043 2242683 2245781 - Nodulation protein NolG Involved in the production of Medicago-specific nodulation signal molecule. Belongs to the resistance-nodulation-cell division (RND) (TC 2. A. 6) family gene gene2042 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02043 VSVS12_02044 VSVS12_02044 VSVS12_02044 2245774 2246859 - Multidrug resistance protein MdtA Belongs to the membrane fusion protein (MFP) (TC 8. A. 1) family gene gene2043 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02044 VSVS12_02045 VSVS12_02045 VSVS12_02045 2246861 2247892 - putative efflux pump periplasmic linker protein SepA Probable periplasmic linker protein component of the SepABC efflux pump with unknown specificity. Belongs to the membrane fusion protein (MFP) (TC 8. A. 1) family gene gene2044 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02045 VSVS12_02046 VSVS12_02046 VSVS12_02046 2248092 2248478 - Phage shock protein The phage shock protein (psp) operon (pspABCDE) may play a significant role in the competition for survival under nutrient- or energy-limited conditions. PspC is involved in transcription regulation (By similarity)%3B Belongs to the phageshock PspC family gene gene2045 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02046 VSVS12_02047 VSVS12_02047 VSVS12_02047 2248471 2248704 - hypothetical protein gene gene2046 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02047 VSVS12_02048 VSVS12_02048 VSVS12_02048 2248789 2249457 - Phage shock protein The phage shock protein (psp) operon (pspABCDE) may play a significant role in the competition for survival under nutrient- or energy-limited conditions. PspA negatively regulates expression of the pspABCDE promoter and of pspG through negative regulation of the psp-specific transcriptional activator PspF. Is also required for membrane integrity%2C efficient translocation and maintenance of the proton motive force (By similarity)%3B Belongs to the PspA/IM30 family gene gene2047 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02048 VSVS12_02049 VSVS12_02049 VSVS12_02049 2249696 2250697 + Anaerobic nitric oxide reductase transcription regulator NorR Required for the expression of anaerobic nitric oxide (NO) reductase%2C acts as a transcriptional activator for at least the norVW operon. Activation also requires sigma-54%3B Contains 1 sigma-54 factor interaction domain gene gene2048 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02049 VSVS12_02050 VSVS12_02050 VSVS12_02050 2250867 2252510 + Periplasmic dipeptide transport protein Dipeptide-binding protein of a transport system that can be subject to osmotic shock. DppA is also required for peptide chemotaxis. Belongs to the bacterial solute-binding protein 5 family gene gene2049 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02050 VSVS12_02051 VSVS12_02051 VSVS12_02051 2252511 2253473 + Peptide transport system permease protein Involved in a peptide intake transport system that plays a role in the resistance to antimicrobial peptides%3B Belongs to the binding-protein-dependent transport system permease family. OppBC subfamily%3B Contains 1 ABC transmembrane type-1 domain gene gene2050 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02051 VSVS12_02052 VSVS12_02052 VSVS12_02052 2253460 2254347 + Peptide transport system permease protein SapC Involved in a peptide intake transport system that plays a role in the resistance to antimicrobial peptides%3B Belongs to the binding-protein-dependent transport system permease family. OppBC subfamily%3B Contains 1 ABC transmembrane type-1 domain gene gene2051 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02052 VSVS12_02053 VSVS12_02053 VSVS12_02053 2254347 2255342 + Dipeptide transport ATP-binding protein DppD Part of the binding-protein-dependent transport system for dipeptides. Probably responsible for energy coupling to the transport system (By similarity)%3B Belongs to the ABC transporter superfamily%3B Contains 1 ABC transporter domain gene gene2052 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02053 VSVS12_02054 VSVS12_02054 VSVS12_02054 2255339 2256124 + Nickel import ATP-binding protein Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system%3B Belongs to the ABC transporter superfamily. Nickel importer (TC 3. A. 1. 5. 3) family%3B Contains 1 ABC transporter domain gene gene2053 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02054 VSVS12_02055 VSVS12_02055 ppaC ppaC 2256251 2257156 - Inorganic diphosphatase Belongs to the PPase class C family%3B KEGG: vch:VC1687 manganese-dependent inorganic pyrophosphatase gene gene2054 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02055 VSVS12_02056 VSVS12_02056 VSVS12_02056 2257392 2258597 + hypothetical protein gene gene2055 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02056 VSVS12_02057 VSVS12_02057 VSVS12_02057 2258823 2259458 - Phosphoribosyl-ATP diphosphatase In the N-terminal sectio%3B belongs to the PRA-CH family%3B In the C-terminal sectio%3B belongs to the PRA-PH family%3B KEGG: vcy:IX92_09500 phosphoribosyl-ATP pyrophosphohydrolase / phosphoribosyl-AMP cyclohydrolase gene gene2056 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02057 VSVS12_02058 VSVS12_02058 VSVS12_02058 2259455 2260243 - Imidazole glycerol phosphate synthase subunit hisF1 IGPS catalyzes the conversion of PRFAR and glutamine to IGP%2C AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity)%3B Belongs to the HisA/HisF family%3B KEGG: eco:b2025 cyclase%3B Oxo-acid-lyases gene gene2057 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02058 VSVS12_02059 VSVS12_02059 hisA hisA 2260225 2260962 - 1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamideisomerase Belongs to the HisA/HisF family%3B KEGG: eco:b2024 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase gene gene2058 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02059 VSVS12_02060 VSVS12_02060 VSVS12_02060 2260975 2261589 - Imidazole glycerol phosphate synthase subunit HisH IGPS catalyzes the conversion of PRFAR and glutamine to IGP%2C AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity)%3B Contains 1 glutamine amidotransferase type-1 domain%3B KEGG: vvu:VV1_2916 glutamine amidotransferase%3B Pentosyltransferases gene gene2059 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02060 VSVS12_02061 VSVS12_02061 hisB hisB 2261599 2262672 - Imidazoleglycerol-phosphate dehydratase In the N-terminal sectio%3B belongs to the histidinol- phosphatase family%3B In the C-terminal sectio%3B belongs to the imidazoleglycerol-phosphate dehydratase family%3B KEGG: gan:UMN179_01801 imidazoleglycerol-phosphate dehydratase / histidinol-phosphatase gene gene2060 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02061 VSVS12_02062 VSVS12_02062 hisC hisC 2262764 2263804 - Histidinol-phosphate transaminase Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily%3B KEGG: vpa:VP1139 histidinol-phosphate aminotransferase gene gene2061 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02062 VSVS12_02063 VSVS12_02063 hisD hisD 2263804 2265105 - Histidinol dehydrogenase Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine%3B Belongs to the histidinol dehydrogenase family%3B KEGG: pmu:PM1198 histidinol dehydrogenase gene gene2062 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02063 VSVS12_02064 VSVS12_02064 hisG hisG 2265110 2266006 - ATP phosphoribosyltransferase Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity%3B Belongs to the ATP phosphoribosyltransferase family. Long subfamily%3B KEGG: vch:VC1132 ATP phosphoribosyltransferase gene gene2063 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02064 VSVS12_02065 VSVS12_02065 VSVS12_02065 2266410 2268005 - uncharacterized protein gene gene2064 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02065 VSVS12_02066 VSVS12_02066 VSVS12_02066 2268820 2269227 + DNA-binding protein H-NS like protein Binds tightly to ds-DNA%2C increases its thermal stability and inhibits transcription%3B Belongs to the histone-like protein H-NS family gene gene2065 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02066 VSVS12_02067 VSVS12_02067 VSVS12_02067 2269332 2270636 - Inosine kinase Belongs to the carbohydrate kinase PfkB family%3B KEGG: eco:b0477 inosine kinase gene gene2066 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02067 VSVS12_02068 VSVS12_02068 VSVS12_02068 2270729 2270998 - hypothetical protein gene gene2067 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02068 VSVS12_02069 VSVS12_02069 mnmA mnmA 2271322 2272443 + tRNA-specific 2-thiouridylase MnmA Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA%2C leading to the formation of s(2)U34%3B Belongs to the MnmA/TRMU family%3B KEGG: vcy:IX92_09560 tRNA-specific 2-thiouridylase%3B Sulfurtransferases gene gene2068 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02069 VSVS12_02070 VSVS12_02070 VSVS12_02070 2272471 2273088 + High frequency lysogenization protein HflD like protein Belongs to the HflD family gene gene2069 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02070 VSVS12_02071 VSVS12_02071 purB purB 2273239 2274609 + Adenylosuccinate lyase Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily%3B KEGG: hdu:HD1649 adenylosuccinate lyase gene gene2070 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02071 VSVS12_02072 VSVS12_02072 VSVS12_02072 2274679 2275209 - hypothetical protein gene gene2071 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02072 VSVS12_02073 VSVS12_02073 VSVS12_02073 2275206 2275796 - hypothetical protein gene gene2072 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02073 VSVS12_02074 VSVS12_02074 VSVS12_02074 2275774 2276280 - hypothetical protein gene gene2073 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02074 VSVS12_02075 VSVS12_02075 VSVS12_02075 2276290 2277531 - Cyclopropane-fatty-acyl-phospholipid synthase Catalyzes the conversion of a double bond to a cyclopropane ring at the distal position of an alpha mycolic acid via the transfer of a methylene group from S-adenosyl-L- methionine. Cyclopropanated mycolic acids are key factors participating in cell envelope permeability%2C host immunomodulation and persistence%3B Belongs to the CFA/CMAS family%3B KEGG: van:VAA_02271 cyclopropane-fatty-acyl-phospholipid synthase gene gene2074 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02075 VSVS12_02076 VSVS12_02076 VSVS12_02076 2277536 2278342 - hypothetical protein gene gene2075 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02076 VSVS12_02077 VSVS12_02077 VSVS12_02077 2278344 2279648 - hypothetical protein gene gene2076 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02077 VSVS12_02078 VSVS12_02078 dltE dltE 2279662 2280387 - L-xylulose reductase Catalyzes the NADPH-dependent reduction of several pentoses%2C tetroses%2C trioses%2C alpha-dicarbonyl compounds and L- xylulose. Participates in the uronate cycle of glucose metabolism. May play a role in the water absorption and cellular osmoregulation in the proximal renal tubules by producing xylitol%2C an osmolyte%2C thereby preventing osmolytic stress from occurring in the renal tubules. Belongs to the short-chain dehydrogenases/reductases (SDR) family%3B KEGG: buo:BRPE64_CCDS01240 uncharacterized oxidoreductase%3B Oxidoreductases gene gene2077 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02078 VSVS12_02079 VSVS12_02079 VSVS12_02079 2280384 2280803 - hypothetical protein gene gene2078 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02079 VSVS12_02080 VSVS12_02080 htpX htpX 2280989 2281858 - Protease HtpX Belongs to the peptidase M48B family%3B KEGG: vch:VC1117 heat shock protein HtpX%3B Metalloendopeptidases gene gene2079 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02080 VSVS12_02081 VSVS12_02081 VSVS12_02081 2282208 2282375 + hypothetical protein gene gene2080 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02081 VSVS12_02082 VSVS12_02082 bioD bioD 2282481 2283161 - Dethiobiotin synthase Catalyzes a mechanistically unusual reaction%2C the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7%2C8-diaminopelargonic acid (DAPA) to form an ureido ring%3B Belongs to the dethiobiotin synthetase family%3B KEGG: vpa:VP1116 dethiobiotin synthetase gene gene2081 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02082 VSVS12_02083 VSVS12_02083 bioC bioC 2283158 2283976 - Malonyl-[acyl-carrier protein] O-methyltransferase Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway%3B Belongs to the methyltransferase superfamily%3B KEGG: vha:VIBHAR_01809 malonyl-CoA O-methyltransferase gene gene2082 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02083 VSVS12_02084 VSVS12_02084 bioF bioF 2283980 2285122 - 8-amino-7-oxononanoate synthase Catalyzes the decarboxylative condensation of pimeloyl- [acyl-carrier protein] and L-alanine to produce 8-amino-7- oxononanoate (AON)%2C [acyl-carrier protein]%2C and carbon dioxide%3B Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily%3B KEGG: ent:Ent638_1267 8-amino-7-oxononanoate synthase gene gene2083 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02084 VSVS12_02085 VSVS12_02085 bioB bioB 2285106 2286158 - Biotin synthase Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism%3B Belongs to the radical SAM superfamily. Biotin synthase family%3B KEGG: vch:VC1112 biotin synthase gene gene2084 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02085 VSVS12_02086 VSVS12_02086 bioA bioA 2286322 2287596 + Adenosylmethionine--8-amino-7-oxononanoate transaminase Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7%2C8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor%3B Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily%3B KEGG: vtu:IX91_05825 adenosylmethionine---8-amino-7-oxononanoate aminotransferase gene gene2085 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02086 VSVS12_02087 VSVS12_02087 VSVS12_02087 2287663 2288346 - UPF0319 protein Belongs to the UPF0319 family gene gene2086 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02087 VSVS12_02088 VSVS12_02088 VSVS12_02088 2288436 2289425 - hypothetical protein gene gene2087 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02088 VSVS12_02089 VSVS12_02089 VSVS12_02089 2289937 2292009 + DNA helicase Probable helicase involved in DNA repair and perhaps also replication%3B Belongs to the helicase family. DinG subfamily%3B Contains 1 helicase ATP-binding domain%3B Contains 1 helicase C-terminal domain%3B KEGG: vcy:IX92_09655 ATP-dependent DNA helicase DinG gene gene2088 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02089 VSVS12_02090 VSVS12_02090 VSVS12_02090 2292084 2292863 + UPF0721 transmembrane protein Belongs to the UPF0721 family gene gene2089 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02090 VSVS12_02091 VSVS12_02091 VSVS12_02091 2292860 2293408 + hypothetical protein gene gene2090 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02091 VSVS12_02092 VSVS12_02092 VSVS12_02092 2293411 2293575 + uncharacterized protein gene gene2091 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02092 VSVS12_02093 VSVS12_02093 ycfD ycfD 2293587 2294726 + 50S ribosomal protein L16 3-hydroxylase Growth-regulating oxygenase that catalyzes the hydroxylation of 50S ribosomal protein L16 on 'Arg-81'%3B Contains 1 JmjC domain%3B KEGG: sbl:Sbal_2481 50S ribosomal protein L16 3-hydroxylase gene gene2092 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02093 VSVS12_02094 VSVS12_02094 xthA xthA 2294765 2295571 + Exodeoxyribonuclease III Major apurinic-apyrimidinic endonuclease of E. coli. It removes the damaged DNA at cytosines and guanines by cleaving on the 3'-side of the AP site by a beta-elimination reaction. It exhibits 3'-5'-exonuclease%2C 3'-phosphomonoesterase%2C 3'-repair diesterase and ribonuclease H activities. Belongs to the DNA repair enzymes AP/ExoA family%3B KEGG: eca:ECA2335 exodeoxyribonuclease III gene gene2093 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02094 VSVS12_02095 VSVS12_02095 VSVS12_02095 2295770 2297464 + Proteases secretion ATP-binding protein PrtD Involved in the secretion of proteases A%2C B%2C C and G. Belongs to the ABC transporter superfamily%3B Contains 1 ABC transmembrane type-1 domain%3B Contains 1 ABC transporter domain gene gene2094 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02095 VSVS12_02096 VSVS12_02096 VSVS12_02096 2297457 2298806 + Type I secretion system membrane fusion protein PrsE Mediates secretion of glycanase ExsH%3B Belongs to the membrane fusion protein (MFP) (TC 8. A. 1) family gene gene2095 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02096 VSVS12_02097 VSVS12_02097 VSVS12_02097 2299016 2301982 + Serralysin Converts beta-D-mannuronic acid (M) to alpha-L-guluronic acid (G)%2C producing a polymer with gel-forming capacity%2C required for the formation of the cyst coat. Belongs to the D-mannuronate C5-epimerase family%3B Contains 12 hemolysin-type calcium-binding repeats%3B Contains 15 PbH1 repeats%3B KEGG: mei:Msip34_2776 serralysin gene gene2096 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02097 VSVS12_02098 VSVS12_02098 VSVS12_02098 2302147 2303349 - Enoyl-[acyl-carrier-protein] reductase (NADH) Involved in the final reduction of the elongation cycle of fatty acid synthesis (FAS II). Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP)%3B Belongs to the TER reductase family%3B KEGG: ype:YPO4104 enoyl-(acyl-carrier protein) reductase / trans-2-enoyl-CoA reductase (NAD+) gene gene2097 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02098 VSVS12_02099 VSVS12_02099 VSVS12_02099 2303546 2305855 - Acyl-coenzyme A dehydrogenase Catalyzes the dehydrogenation of acyl-CoA%3B Belongs to the acyl-CoA dehydrogenase family%3B KEGG: vch:VC1740 null%3B With other acceptors gene gene2098 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02099 VSVS12_02100 VSVS12_02100 VSVS12_02100 2305999 2306667 - hypothetical protein gene gene2099 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02100 VSVS12_02101 VSVS12_02101 VSVS12_02101 2307112 2307540 - hypothetical protein gene gene2100 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02101 VSVS12_02102 VSVS12_02102 VSVS12_02102 2307537 2308946 - hypothetical protein gene gene2101 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02102 VSVS12_02103 VSVS12_02103 arnC arnC 2308943 2309947 - Undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase Involved in O antigen modification. Catalyzes the transfer of the glucose residue from UDP-glucose to a lipid carrier (By similarity)%3B Belongs to the glycosyltransferase 2 family. GtrB subfamily%3B KEGG: cvi:CV_0749 undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase gene gene2102 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02103 VSVS12_02104 VSVS12_02104 VSVS12_02104 2310135 2310812 + Response regulator ArlR Member of the two-component regulatory system ArlS/ArlR%3B Contains 1 OmpR/PhoB-type DNA-binding domain%3B Contains 1 response regulatory domain gene gene2103 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02104 VSVS12_02105 VSVS12_02105 tctE tctE 2310809 2312068 + Histidine kinase KEGG: xdo:XDD1_2646 two-component system%2C OmpR family%2C sensor histidine kinase TctE gene gene2104 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02105 VSVS12_02106 VSVS12_02106 VSVS12_02106 2312181 2313074 + 1-aminocyclopropane-1-carboxylate deaminase KEGG: shn:Shewana3_2469 1-aminocyclopropane-1-carboxylate deaminase gene gene2105 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02106 VSVS12_02107 VSVS12_02107 VSVS12_02107 2313116 2313427 + hypothetical protein gene gene2106 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02107 VSVS12_02108 VSVS12_02108 VSVS12_02108 2313634 2314611 + Cytochrome-c peroxidase KEGG: gan:UMN179_00536 cytochrome c peroxidase gene gene2107 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02108 VSVS12_02109 VSVS12_02109 VSVS12_02109 2314604 2316982 + Histidine kinase Acts as a receptor histidine kinase for a signal transduction pathway. This protein undergoes an ATP-dependent autophosphorylation at a conserved histidine residue in the kinase core%2C and a phosphoryl group is then transferred to a conserved aspartate residue in the receiver domain (By similarity)%3B Contains 12 HAMP domains%3B Contains 1 histidine kinase domain%3B Contains 2 response regulatory domains%3B KEGG: pec:W5S_1553 two-component system%2C NarL family%2C sensor histidine kinase EvgS gene gene2108 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02109 VSVS12_02110 VSVS12_02110 VSVS12_02110 2317106 2317354 + hypothetical protein gene gene2109 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02110 VSVS12_02111 VSVS12_02111 VSVS12_02111 2317513 2318943 - S-methyl-5'-thioadenosine deaminase Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine%2C respectively. Is also able to deaminate adenosine%3B Belongs to the MTA/SAH deaminase family%3B KEGG: dpr:Despr_0311 5-methylthioadenosine/S-adenosylhomocysteine deaminase gene gene2110 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02111 VSVS12_02112 VSVS12_02112 VSVS12_02112 2319151 2319702 + uncharacterized protein gene gene2111 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02112 VSVS12_02113 VSVS12_02113 VSVS12_02113 2319792 2320004 - hypothetical protein gene gene2112 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02113 VSVS12_02114 VSVS12_02114 VSVS12_02114 2320091 2321179 - hypothetical protein gene gene2113 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02114 VSVS12_02115 VSVS12_02115 VSVS12_02115 2321183 2322313 - uncharacterized protein gene gene2114 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02115 VSVS12_02116 VSVS12_02116 VSVS12_02116 2322724 2323041 - hypothetical protein gene gene2115 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02116 VSVS12_02117 VSVS12_02117 VSVS12_02117 2323298 2323450 - hypothetical protein gene gene2116 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02117 VSVS12_02118 VSVS12_02118 VSVS12_02118 2323447 2324613 - hypothetical protein gene gene2117 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02118 VSVS12_02119 VSVS12_02119 VSVS12_02119 2324597 2325265 - Protein TonB Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates such as cobalamin%2C and various iron compounds (such as iron dicitrate%2C enterochelin%2C aerobactin%2C etc.). In the absence of TonB these receptors bind their substrates but do not carry out active transport. TonB also interacts with some colicins and is involved in the energy- dependent%2C irreversible steps of bacteriophages phi 80 and T1 infection. It could act to transduce energy from the cytoplasmic membrane to specific energy-requiring processes in the outer membrane%2C resulting in the release into the periplasm of ligands bound by these outer membrane proteins. Implicated in hydroxy radical-mediated cell death induced by hydroxyurea treatment (PubMed:20005847)%3B Belongs to the TonB family gene gene2118 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02119 VSVS12_02120 VSVS12_02120 VSVS12_02120 2325240 2325641 - Biopolymer transport protein exbD2 Involved in the TonB-dependent energy-dependent transport of various receptor-bound substrates%3B Belongs to the ExbD/TolR family gene gene2119 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02120 VSVS12_02121 VSVS12_02121 VSVS12_02121 2325625 2326143 - hypothetical protein gene gene2120 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02121 VSVS12_02122 VSVS12_02122 VSVS12_02122 2326144 2327433 - Biopolymer transport protein Involved in the TonB-dependent energy-dependent transport of various receptor-bound substrates. Protects ExbD from proteolytic degradation and functionally stabilizes TonB (By similarity)%3B Belongs to the ExbB/TolQ family gene gene2121 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02122 VSVS12_02123 VSVS12_02123 VSVS12_02123 2327433 2328215 - hypothetical protein gene gene2122 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02123 VSVS12_02124 VSVS12_02124 VSVS12_02124 2328443 2330917 + uncharacterized protein To H. influenzae HI_1369 gene gene2123 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02124 VSVS12_02125 VSVS12_02125 VSVS12_02125 2330981 2332663 + Inner membrane ABC transporter ATP-binding protein Belongs to the ABC transporter superfamily%3B Contains 1 ABC transmembrane type-1 domain%3B Contains 1 ABC transporter domain gene gene2124 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02125 VSVS12_02126 VSVS12_02126 pqqL pqqL 2332668 2335499 + putative zinc protease PqqL Belongs to the peptidase M16 family%3B KEGG: pmr:PMI3704 zinc protease%3B Metalloendopeptidases gene gene2125 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02126 VSVS12_02127 VSVS12_02127 rbsK rbsK 2335860 2336810 - Ribokinase Belongs to the carbohydrate kinase PfkB family%3B KEGG: cwo:Cwoe_1176 ribokinase gene gene2126 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02127 VSVS12_02128 VSVS12_02128 VSVS12_02128 2336822 2338237 - hypothetical protein gene gene2127 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02128 VSVS12_02129 VSVS12_02129 VSVS12_02129 2338209 2339300 - uncharacterized protein Belongs to the ADP-ribosylglycohydrolase family gene gene2128 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02129 VSVS12_02130 VSVS12_02130 VSVS12_02130 2339445 2340191 + putative HTH-type transcriptional regulator YurK Contains 1 HTH gntR-type DNA-binding domain gene gene2129 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02130 VSVS12_02131 VSVS12_02131 VSVS12_02131 2340509 2341648 - Type-2 restriction enzyme HphI gene gene2130 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02131 VSVS12_02132 VSVS12_02132 VSVS12_02132 2341649 2342257 - hypothetical protein gene gene2131 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02132 VSVS12_02133 VSVS12_02133 VSVS12_02133 2342778 2342865 - tRNA-Ser tRNA gene2132 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02133 VSVS12_02134 VSVS12_02134 VSVS12_02134 2343014 2343463 - L-alanine exporter AlaE Exports L-alanine%3B Belongs to the AlaE exporter family gene gene2133 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02134 VSVS12_02135 VSVS12_02135 VSVS12_02135 2343705 2346125 - Histidine kinase Cytokinins (CK) receptor related to bacterial two- component regulators. Functions as a histidine kinase and transmits the stress signal to a downstream MAPK cascade. This protein undergoes an ATP-dependent autophosphorylation at a conserved histidine residue in the kinase core%2C and a phosphoryl group is then transferred to a conserved aspartate residue in the receiver domain. In the presence of cytokinin%2C feed phosphate to phosphorelay-integrating histidine phosphotransfer protein (HPt) and activates subsequent cascade. Involved in meristems establishment in seedlings. Redundant negative regulator of drought and salt stress responses and abscisic acid (ABA) signaling. Together with AHK2%2C plays a negative regulatory role in cold stress signaling via inhibition of ABA response%2C occurring independently of the cold acclimation pathway. Redundant positive regulator of cytokinin signaling that regulates many development process including seed germination%2C cell division%2C seed size%2C chlorophyll retention during leaf senescence%2C root repression and shoot promotion. Can interact with isoprenoid-type cytokinins trans-zeatin (tZ and tZR)%2C cis-zeatin (cZ)%2C dihydrozeatin (DZ)%2C buta-2%2C3-dienyladenine (HA-8)%2C penta-2%2C3-dienyladenine (HA-1)%2C 4- methyl-penta-2%2C3-dienyladenine (HA-10)%2C 4-hydroxy-2-butynyladenine (RM1)%2C 2-propynyladenine (RM3)%2C 2-butynyladenine (RM6)%2C and cytokinin ribosides and ribotides. Together with AHK4%2C involved in the cytokinin-dependent responses to Pi starvation and sucrose stresses. Promotes cytokinin-mediated leaf longevity through a specific phosphorylation of the response regulator ARR2. Involved in alkamides (e. g. N-isobutyl decanamide) and N-acylethanolamides (NAE) signaling that control meristematic activity and differentiation processes during plant development. Contributes to vascular bundle formation and secondary growth in a cytokinin- dependent manner%2C probably by promoting the maintenance of mitotic activity and/or identity of procambial cells. Plays a role in the cytokinin-mediated repression of the iron uptake pathway. Required by the cytokinin-dependent flower development regulation pathway%3B Contains 1 CHASE domain%3B Contains 1 histidine kinase domain%3B Contains 2 response regulatory domains%3B KEGG: vfi:VF_A0360 null%3B Phosphotransferases with a nitrogenous group as acceptor gene gene2134 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02135 VSVS12_02136 VSVS12_02136 VSVS12_02136 2346242 2346826 + hypothetical protein gene gene2135 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02136 VSVS12_02137 VSVS12_02137 VSVS12_02137 2346948 2347979 - hypothetical protein gene gene2136 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02137 VSVS12_02138 VSVS12_02138 nadA nadA 2348222 2349283 - Quinolinate synthase Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate%3B Belongs to the quinolinate synthase A family. Type 1 subfamily%3B KEGG: vvu:VV1_2173 quinolinate synthase gene gene2137 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02138 VSVS12_02139 VSVS12_02139 VSVS12_02139 2349414 2350187 - uncharacterized protein gene gene2138 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02139 VSVS12_02140 VSVS12_02140 VSVS12_02140 2350203 2350718 - Peptidoglycan-associated lipoprotein Thought to play a role in bacterial envelope integrity. Very strongly associated with the peptidoglycan (By similarity)%3B Belongs to the OmpA family. Pal subfamily%3B Contains 1 OmpA-like domain gene gene2139 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02140 VSVS12_02141 VSVS12_02141 VSVS12_02141 2350753 2352105 - Protein TolB Involved in the TonB-independent uptake of proteins%3B Belongs to the TolB family gene gene2140 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02141 VSVS12_02142 VSVS12_02142 VSVS12_02142 2352121 2353206 - Coiled-coil domain-containing protein 88B Belongs to the CCDC88 family gene gene2141 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02142 VSVS12_02143 VSVS12_02143 VSVS12_02143 2353220 2353663 - Protein TolR Involved in the TonB-independent uptake of proteins%3B Belongs to the ExbD/TolR family gene gene2142 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02143 VSVS12_02144 VSVS12_02144 VSVS12_02144 2353667 2354350 - hypothetical protein Involved in the TonB-independent uptake of proteins%3B Belongs to the ExbB/TolQ family gene gene2143 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02144 VSVS12_02145 VSVS12_02145 ybgC ybgC 2354340 2354759 - Acyl-CoA thioester hydrolase Thioesterase that appears to be involved in phospholipid metabolism. Some specific acyl-ACPs could be physiological substrates. Displays acyl-CoA thioesterase activity on malonyl-CoA in vitro%2C catalyzing the hydrolysis of the thioester bond (By similarity)%3B Belongs to the 4-hydroxybenzoyl-CoA thioesterase family%3B KEGG: eco:b0736 acyl-CoA thioester hydrolase%3B Thiolester hydrolases gene gene2144 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02145 VSVS12_02146 VSVS12_02146 VSVS12_02146 2354925 2355227 - hypothetical protein gene gene2145 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02146 VSVS12_02147 VSVS12_02147 VSVS12_02147 2355220 2355327 - Cytochrome bd-I ubiquinol oxidase subunit Required for correct functioning of cytochrome bd-I oxidase. This protein and AppX may have some functional overlap. Belongs to the cytochrome ubiquinol oxidase subunit X family gene gene2146 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02147 VSVS12_02148 VSVS12_02148 cydB cydB 2355340 2356476 - Cytochrome bd-II ubiquinol oxidase subunit A terminal oxidase that catalyzes quinol-dependent%2C Na(+)-independent oxygen uptake. Prefers menadiol over other quinols although ubiquinol was not tested (PubMed:8626304). Generates a proton motive force using protons and electrons from opposite sides of the membrane to generate H(2)O%2C transferring 1 proton/electron%3B Belongs to the cytochrome ubiquinol oxidase subunit 2 family%3B KEGG: eco:b0734 cytochrome d ubiquinol oxidase subunit II%3B With oxygen as acceptor gene gene2147 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02148 VSVS12_02149 VSVS12_02149 cydA cydA 2356488 2358074 - Cytochrome bd-II ubiquinol oxidase subunit A terminal oxidase that catalyzes quinol-dependent%2C Na(+)-independent oxygen uptake. Prefers menadiol over other quinols although ubiquinol was not tested (PubMed:8626304). Generates a proton motive force using protons and electrons from opposite sides of the membrane to generate H(2)O%2C transferring 1 proton/electron%3B Belongs to the cytochrome ubiquinol oxidase subunit 1 family%3B KEGG: eco:b0733 cytochrome d ubiquinol oxidase subunit I%3B With oxygen as acceptor gene gene2148 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02149 VSVS12_02150 VSVS12_02150 ruvB ruvB 2358605 2359609 - DNA helicase RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing%3B Belongs to the RuvB family%3B KEGG: vch:VC1845 holliday junction DNA helicase RuvB gene gene2149 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02150 VSVS12_02151 VSVS12_02151 ruvA ruvA 2359622 2360239 - DNA helicase RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates%2C in the presence of DNA%2C the weak ATPase activity of RuvB%3B Belongs to the RuvA family%3B KEGG: eco:b1861 holliday junction DNA helicase RuvA gene gene2150 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02151 VSVS12_02152 VSVS12_02152 ruvC ruvC 2360338 2360859 - Crossover junction endodeoxyribonuclease Nuclease that resolves Holliday junction intermediates in genetic recombination%3B Belongs to the RuvC family%3B KEGG: eco:b1863 crossover junction endodeoxyribonuclease RuvC gene gene2151 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02152 VSVS12_02153 VSVS12_02153 galA galA 2360925 2362664 - Alpha-galactosidase KEGG: vha:VIBHAR_01858 alpha-galactosidase gene gene2152 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02153 VSVS12_02154 VSVS12_02154 torA torA 2362963 2365425 - Trimethylamine-N-oxide reductase (cytochrome c) Reduces trimethylamine-N-oxide (TMAO) into trimethylamin%3B an anaerobic reaction coupled to energy-yielding reactions%3B Belongs to the prokaryotic molybdopterin-containing oxidoreductase family%3B KEGG: vch:VC1692 trimethylamine-N-oxide reductase (cytochrome c) gene gene2153 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02154 VSVS12_02155 VSVS12_02155 VSVS12_02155 2365450 2366634 - Cytochrome c-type protein NapC gene gene2154 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02155 VSVS12_02156 VSVS12_02156 VSVS12_02156 2366685 2366975 - Protein NapE gene gene2155 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02156 VSVS12_02157 VSVS12_02157 VSVS12_02157 2367302 2368093 + UPF0014 membrane protein Belongs to the UPF0014 family gene gene2156 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02157 VSVS12_02158 VSVS12_02158 VSVS12_02158 2368285 2368461 + hypothetical protein gene gene2157 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02158 VSVS12_02159 VSVS12_02159 VSVS12_02159 2368631 2369482 - putative formate transporter Involved in the bidirectional transport of formate%3B Belongs to the FNT transporter (TC 2. A. 44) family gene gene2158 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02159 VSVS12_02160 VSVS12_02160 VSVS12_02160 2369929 2370168 + hypothetical protein gene gene2159 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02160 VSVS12_02161 VSVS12_02161 VSVS12_02161 2370250 2370678 - hypothetical protein gene gene2160 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02161 VSVS12_02162 VSVS12_02162 VSVS12_02162 2370767 2371660 + putative RuBisCO transcriptional regulator Trans-acting transcriptional regulator of RuBisCO genes (rbcL and rbcS) expression%3B Contains 1 HTH lysR-type DNA-binding domain gene gene2161 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02162 VSVS12_02163 VSVS12_02163 VSVS12_02163 2371674 2372495 + Protein YeeZ gene gene2162 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02163 VSVS12_02164 VSVS12_02164 VSVS12_02164 2372507 2373148 + uncharacterized protein The imp locus inhibits the extrachromosomal maintenance of the streptomyces plasmid SLP1. May function as a transcriptional activator. To E. coli YdcF gene gene2163 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02164 VSVS12_02165 VSVS12_02165 VSVS12_02165 2373221 2375491 - ATP-dependent Clp protease ATP-binding subunit ATP-dependent specificity component of the ClpAP protease. It directs the protease to specific substrates. It has unfoldase activity. The primary function of the ClpA-ClpP complex appears to be the degradation of unfolded or abnormal proteins (By similarity)%3B Belongs to the ClpA/ClpB family gene gene2164 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02165 VSVS12_02166 VSVS12_02166 VSVS12_02166 2375534 2375854 - ATP-dependent Clp protease adapter protein ClpS Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation%3B Belongs to the ClpS family gene gene2165 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02166 VSVS12_02167 VSVS12_02167 VSVS12_02167 2376314 2376535 + Cold shock-like protein 7.0 Contains 1 CSD (cold-shock) domain gene gene2166 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02167 VSVS12_02168 VSVS12_02168 idh1 idh1 2376620 2378845 - Isocitrate dehydrogenase (NADP(+)) Belongs to the monomeric-type IDH family%3B KEGG: vch:VC1141 isocitrate dehydrogenase gene gene2167 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02168 VSVS12_02169 VSVS12_02169 rluE rluE 2379137 2379829 + 23S rRNA pseudouridine(2457) synthase Responsible for synthesis of pseudouridine from uracil- 2457 in 23S ribosomal RNA%3B Belongs to the pseudouridine synthase RsuA family%3B KEGG: vct:JV59_28475 23S rRNA pseudouridine2457 synthase gene gene2168 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02169 VSVS12_02170 VSVS12_02170 VSVS12_02170 2380478 2382643 + hypothetical protein gene gene2169 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02170 VSVS12_02171 VSVS12_02171 VSVS12_02171 2382645 2383160 + Thioredoxin-like protein Belongs to the thioredoxin family%3B Contains 1 thioredoxin domain gene gene2170 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02171 VSVS12_02172 VSVS12_02172 darS darS 2383255 2385033 - Aspartate--tRNA ligase Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn)%3B Belongs to the class-II aminoacyl-tRNA synthetase family%3B KEGG: mvi:X808_4800 aspartyl-tRNA synthetase gene gene2171 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02172 VSVS12_02173 VSVS12_02173 VSVS12_02173 2385307 2386173 + UPF0759 protein Belongs to the UPF0759 family gene gene2172 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02173 VSVS12_02174 VSVS12_02174 cmoA cmoA 2386290 2387027 + tRNA (cmo5U34)-methyltransferase Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U)%3B Belongs to the methyltransferase superfamily. CmoA family%3B KEGG: vvu:VV1_2154 tRNA (cmo5U34)-methyltransferase%3B Methyltransferases gene gene2173 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02174 VSVS12_02175 VSVS12_02175 cmoB cmoB 2387141 2388112 + tRNA (mo5U34)-methyltransferase Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA%3B Belongs to the methyltransferase superfamily. CmoB family%3B KEGG: vvu:VV1_2153 tRNA (mo5U34)-methyltransferase%3B Methyltransferases gene gene2174 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02175 VSVS12_02176 VSVS12_02176 VSVS12_02176 2388409 2389155 + hypothetical protein gene gene2175 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02176 VSVS12_02177 VSVS12_02177 VSVS12_02177 2389172 2390677 + hypothetical protein gene gene2176 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02177 VSVS12_02178 VSVS12_02178 VSVS12_02178 2390682 2391662 + hypothetical protein gene gene2177 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02178 VSVS12_02179 VSVS12_02179 VSVS12_02179 2391824 2392711 + uncharacterized protein Contains 2 EamA domains gene gene2178 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02179 VSVS12_02180 VSVS12_02180 VSVS12_02180 2392812 2397269 - Chromosome partition protein MukB Plays a central role in chromosome condensation%2C segregation and cell cycle progression. Functions as a homodimer%2C which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo%2C and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division%3B Belongs to the SMC family. MukB subfamily gene gene2179 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02180 VSVS12_02181 VSVS12_02181 VSVS12_02181 2397266 2397979 - Chromosome partition protein MukE Involved in chromosome condensation%2C segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF%3B Belongs to the MukE family gene gene2180 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02181 VSVS12_02182 VSVS12_02182 VSVS12_02182 2397960 2399297 - Chromosome partition protein MukF Involved in chromosome condensation%2C segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity%3B Belongs to the MukF family gene gene2181 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02182 VSVS12_02183 VSVS12_02183 VSVS12_02183 2399294 2400109 - Protein SmtA gene gene2182 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02183 VSVS12_02184 VSVS12_02184 VSVS12_02184 2400206 2401009 + Envelope bioproteinis factor ElyC Plays a critical role in the metabolism of the essential lipid carrier used for cell wall synthesis gene gene2183 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02184 VSVS12_02185 VSVS12_02185 VSVS12_02185 2401118 2401828 - Aerobic respiration control protein Member of the two-component regulatory system ArcB/ArcA. Represses a wide variety of aerobic enzymes under anaerobic conditions. It also may be involved in the osmoregulation of envelope proteins. When activated by ArcB%2C it negatively regulates the expression of genes of aerobic function. Activates the transcription of the plfB operon by binding to its promoter (By similarity)%3B Contains 1 OmpR/PhoB-type DNA-binding domain%3B Contains 1 response regulatory domain gene gene2184 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02185 VSVS12_02186 VSVS12_02186 VSVS12_02186 2402068 2402715 + Chaperone protein TorD Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and%2C as a result%2C probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor%3B Belongs to the TorD/DmsD family. TorD subfamily gene gene2185 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02186 VSVS12_02187 VSVS12_02187 VSVS12_02187 2403087 2404091 + Sucrose operon repressor Repressor for the csc operon. Binds D-fructose as an inducer (By similarity)%3B Contains 1 HTH lacI-type DNA-binding domain gene gene2186 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02187 VSVS12_02188 VSVS12_02188 VSVS12_02188 2404440 2405033 + DNA transformation protein TfoX2 Required for efficient DNA transformation jointly with TfoX1%3B Belongs to the TfoX family gene gene2187 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02188 VSVS12_02189 VSVS12_02189 VSVS12_02189 2405249 2405953 + Phospholipase D Belongs to the TMEM41 family%3B KEGG: reh:H16_B0932 phospholipase D1/2 gene gene2188 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02189 VSVS12_02190 VSVS12_02190 VSVS12_02190 2405953 2406261 + hypothetical protein gene gene2189 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02190 VSVS12_02191 VSVS12_02191 dehH dehH 2406341 2407144 - Haloacetate dehalogenase KEGG: har:HEAR0772 haloacetate dehalogenase gene gene2190 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02191 VSVS12_02192 VSVS12_02192 glgA glgA 2407347 2408804 - Starch synthase Synthesizes alpha-1%2C4-glucan chains using ADP-glucose%3B Belongs to the glycosyltransferase 1 family. Bacterial/plant glycogen synthase subfamily%3B KEGG: vcy:IX92_10105 starch synthase gene gene2191 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02192 VSVS12_02193 VSVS12_02193 glgC glgC 2408794 2410011 - Glucose-1-phosphate adenylyltransferase Catalyzes the synthesis of ADP-glucose%2C a sugar donor used in elongation reactions on alpha-glucans%3B Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family%3B KEGG: vch:VC1727 glucose-1-phosphate adenylyltransferase gene gene2192 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02193 VSVS12_02194 VSVS12_02194 topA topA 2410452 2413073 - DNA topoisomerase Releases the supercoiling and torsional tension of DNA%2C which is introduced during the DNA replication and transcription%2C by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme%2C resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand%2C thus removing DNA supercoils. Finally%2C in the religation step%2C the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone%3B Belongs to the type IA topoisomerase family%3B Contains 1 Toprim domain%3B KEGG: buc:BU284 DNA topoisomerase I gene gene2193 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02194 VSVS12_02195 VSVS12_02195 VSVS12_02195 2413424 2413738 + hypothetical protein gene gene2194 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02195 VSVS12_02196 VSVS12_02196 aroA aroA 2414009 2415304 - 3-phosphoshikimate 1-carboxyvinyltransferase Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate%3B Belongs to the EPSP synthase family%3B KEGG: eco:b0908 3-phosphoshikimate 1-carboxyvinyltransferase gene gene2195 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02196 VSVS12_02197 VSVS12_02197 VSVS12_02197 2415458 2415907 - uncharacterized protein To Rickettsia 17 kDa surface antigen gene gene2196 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02197 VSVS12_02198 VSVS12_02198 VSVS12_02198 2415923 2416639 + Leucyltransferase Functions in the N-end rule pathway of protein degradation where it conjugates Leu%2C Phe and%2C less efficiently%2C Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine%3B Belongs to the L/F-transferase family%3B KEGG: vch:VC1735 leucyl/phenylalanyl-tRNA--protein transferase gene gene2197 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02198 VSVS12_02199 VSVS12_02199 ate1 ate1 2416641 2417339 + Arginyltransferase May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate%3B Belongs to the R-transferase family%3B KEGG: vch:VC1736 arginine-tRNA-protein transferase gene gene2198 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02199 VSVS12_02200 VSVS12_02200 VSVS12_02200 2417421 2417639 + Translation initiation factor IF-1 One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection%2C yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1%2C IF-2 and IF-3 are released leaving the mature 70S translation initation complex%3B Belongs to the IF-1 family%3B Contains 1 S1-like domain gene gene2199 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02200 VSVS12_02201 VSVS12_02201 VSVS12_02201 2417710 2418288 - Thymidine kinase Belongs to the thymidine kinase family%3B KEGG: eco:b1238 thymidine kinase gene gene2200 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02201 VSVS12_02202 VSVS12_02202 carS carS 2418390 2419772 - Cysteine--tRNA ligase Belongs to the class-I aminoacyl-tRNA synthetase family%3B KEGG: eco:b0526 cysteinyl-tRNA synthetase gene gene2201 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02202 VSVS12_02203 VSVS12_02203 ppiB ppiB 2419976 2420470 + Peptidylprolyl isomerase PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Belongs to the cyclophilin-type PPIase family%3B Contains 1 PPIase cyclophilin-type domain%3B KEGG: hin:HI0079 peptidyl-prolyl cis-trans isomerase B (cyclophilin B) gene gene2202 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02203 VSVS12_02204 VSVS12_02204 lpxH lpxH 2420489 2421262 + UDP-2%2C3-diacylglucosamine diphosphatase Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2%2C3-diacylglucosamine to yield 2%2C3-diacylglucosamine 1- phosphate (lipid X) and UMP%3B Belongs to the LpxH family%3B KEGG: xcv:XCV1066 UDP-2%2C3-diacylglucosamine hydrolase gene gene2203 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02204 VSVS12_02205 VSVS12_02205 VSVS12_02205 2421308 2422555 + uncharacterized protein Contains 1 EAL domain gene gene2204 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02205 VSVS12_02206 VSVS12_02206 VSVS12_02206 2422717 2423124 + UPF0225 protein Belongs to the UPF0225 family gene gene2205 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02206 VSVS12_02207 VSVS12_02207 VSVS12_02207 2423182 2423469 - uncharacterized protein To E. coli YeaC gene gene2206 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02207 VSVS12_02208 VSVS12_02208 VSVS12_02208 2423574 2424389 + hypothetical protein gene gene2207 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02208 VSVS12_02209 VSVS12_02209 msrB msrB 2424474 2424893 - Peptide-methionine (R)-S-oxide reductase Belongs to the MsrB Met sulfoxide reductase family%3B KEGG: pseu:Pse7367_0932 peptide-methionine (R)-S-oxide reductase gene gene2208 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02209 VSVS12_02210 VSVS12_02210 VSVS12_02210 2425229 2426224 + Glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) Involved in the glycolysis. Catalyzes the oxidative phosphorylation of glyceraldehyde 3-phosphate (G3P) to 1%2C3- bisphosphoglycerate (BPG) using the cofactor NAD. The first reaction step involves the formation of a hemiacetal intermediate between G3P and a cysteine residue%2C and this hemiacetal intermediate is then oxidized to a thioester%2C with concomitant reduction of NAD to NADH. The reduced NADH is then exchanged with the second NAD%2C and the thioester is attacked by a nucleophilic inorganic phosphate to produce BPG%3B Belongs to the glyceraldehyde-3-phosphate dehydrogenase family%3B KEGG: eco:b1779 glyceraldehyde 3-phosphate dehydrogenase gene gene2209 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02210 VSVS12_02211 VSVS12_02211 VSVS12_02211 2426433 2427314 + Glucose-6-phosphate 1-epimerase Belongs to the Glucose-6-phosphate 1-epimerase family%3B KEGG: vpa:VP2158 glucose-6-phosphate 1-epimerase gene gene2210 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02211 VSVS12_02212 VSVS12_02212 VSVS12_02212 2427475 2428302 + 23S rRNA (guanine(745)-N(1))-methyltransferase Specifically methylates the guanosine in position 745 of 23S rRNA%3B Belongs to the methyltransferase superfamily. RlmA family%3B KEGG: ype:YPO1748 23S rRNA (guanine745-N1)-methyltransferase gene gene2211 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02212 VSVS12_02213 VSVS12_02213 VSVS12_02213 2428624 2428968 + hypothetical protein gene gene2212 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02213 VSVS12_02214 VSVS12_02214 VSVS12_02214 2429091 2430974 + Glycine betaine transporter BetP High-affinity uptake of glycine betaine%3B Belongs to the BCCT transporter (TC 2. A. 15) family gene gene2213 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02214 VSVS12_02215 VSVS12_02215 VSVS12_02215 2431156 2432811 - Small-conductance mechanosensitive channel Mechanosensitive channel that participates in the regulation of osmotic pressure changes within the cell. Forms an ion channel of 1. 0 nanosiemens conductance with a slight preference for anions. The channel is sensitive to voltage (By similarity)%3B Belongs to the MscS (TC 1. A. 23) family gene gene2214 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02215 VSVS12_02216 VSVS12_02216 VSVS12_02216 2433051 2433503 - UPF0260 protein Belongs to the UPF0260 family gene gene2215 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02216 VSVS12_02217 VSVS12_02217 VSVS12_02217 2433643 2433894 + UPF0410 protein Belongs to the UPF0410 family gene gene2216 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02217 VSVS12_02218 VSVS12_02218 VSVS12_02218 2434073 2434369 + UPF0153 protein Belongs to the UPF0153 family gene gene2217 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02218 VSVS12_02219 VSVS12_02219 VSVS12_02219 2434742 2436493 - Acid phosphatase KEGG: rso:RSp1174 acid phosphatase gene gene2218 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02219 VSVS12_02220 VSVS12_02220 VSVS12_02220 2436856 2437554 + Aquaporin Z Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity%3B Belongs to the MIP/aquaporin (TC 1. A. 8) family gene gene2219 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02220 VSVS12_02221 VSVS12_02221 VSVS12_02221 2437833 2438432 - Recombination protein RecR May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO%3B Belongs to the RecR family%3B Contains 1 Toprim domain gene gene2220 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02221 VSVS12_02222 VSVS12_02222 VSVS12_02222 2438449 2438778 - Nucleoid-associated protein Binds to DNA and alters its conformation. May be involved in regulation of gene expression%2C nucleoid organization and DNA protection%3B Belongs to the YbaB/EbfC family gene gene2221 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02222 VSVS12_02223 VSVS12_02223 dnaX dnaX 2438944 2441109 - DNA-directed DNA polymerase DNA polymerase III is a complex%2C multichain enzyme responsible for most of the replicative synthesis in bacteria. Belongs to the DnaX/STICHEL family%3B KEGG: vch:VC1054 DNA polymerase III subunit gamma/tau gene gene2222 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02223 VSVS12_02224 VSVS12_02224 aprT aprT 2441122 2441667 - Adenine phosphoribosyltransferase Catalyzes a salvage reaction resulting in the formation of AMP%2C that is energically less costly than de novo synthesis%3B Belongs to the purine/pyrimidine phosphoribosyltransferase family%3B KEGG: vch:VC1053 adenine phosphoribosyltransferase gene gene2223 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02224 VSVS12_02225 VSVS12_02225 VSVS12_02225 2441817 2442086 - Inner membrane protein gene gene2224 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02225 VSVS12_02226 VSVS12_02226 VSVS12_02226 2442225 2442359 - hypothetical protein gene gene2225 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02226 VSVS12_02227 VSVS12_02227 VSVS12_02227 2442601 2443695 - putative transcriptional regulator ycf27 Probable promoter-specific protein mediating the interaction between DNA and RNA polymerase. Contains 1 OmpR/PhoB-type DNA-binding domain%3B Contains 1 response regulatory domain gene gene2226 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02227 VSVS12_02228 VSVS12_02228 VSVS12_02228 2443887 2444816 + putative HTH-type transcriptional regulator YraN Contains 1 HTH lysR-type DNA-binding domain gene gene2227 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02228 VSVS12_02229 VSVS12_02229 VSVS12_02229 2444908 2445456 - Putative NAD(P)H nitroreductase Belongs to the nitroreductase family gene gene2228 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02229 VSVS12_02230 VSVS12_02230 fadJ fadJ 2445603 2447717 - 3-hydroxyacyl-CoA dehydrogenase Catalyzes the formation of a hydroxyacyl-CoA by addition of water on enoyl-CoA. Also exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities%3B In the N-terminal sectio%3B belongs to the enoyl-CoA hydratase/isomerase family%3B In the central sectio%3B belongs to the 3-hydroxyacyl- CoA dehydrogenase family%3B KEGG: vfu:vfu_A02552 3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase / 3-hydroxybutyryl-CoA epimerase gene gene2229 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02230 VSVS12_02231 VSVS12_02231 VSVS12_02231 2447717 2449024 - Acetyl-CoA C-acyltransferase Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed%3B Belongs to the thiolase family%3B KEGG: vch:VC1046 acetyl-CoA acyltransferase gene gene2230 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02231 VSVS12_02232 VSVS12_02232 VSVS12_02232 2449598 2450161 + RNA polymerase sigma factor SigX Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. May be involved in the regulation of iron metabolism. Belongs to the sigma-70 factor family. ECF subfamily gene gene2231 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02232 VSVS12_02233 VSVS12_02233 VSVS12_02233 2450154 2450885 + hypothetical protein gene gene2232 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02233 VSVS12_02234 VSVS12_02234 VSVS12_02234 2451171 2452469 + Long-chain fatty acid transport protein Involved in translocation of long-chain fatty acids across the outer membrane. FadL may form a specific channel (By similarity)%3B Belongs to the OmpP1/FadL family gene gene2233 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02234 VSVS12_02235 VSVS12_02235 VSVS12_02235 2452813 2454129 + Long-chain fatty acid transport protein Involved in translocation of long-chain fatty acids across the outer membrane. FadL may form a specific channel (By similarity)%3B Belongs to the OmpP1/FadL family gene gene2234 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02235 VSVS12_02236 VSVS12_02236 VSVS12_02236 2454223 2454984 - putative phospholipid-binding lipoprotein MlaA Actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane%3B Belongs to the MlaA family gene gene2235 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02236 VSVS12_02237 VSVS12_02237 VSVS12_02237 2455047 2456267 - Putative cytochrome c-type bioproteinis protein CcmH May be required for the biogenesis of c-type cytochromes. Possible subunit of a heme lyase (By similarity)%3B Belongs to the CcmH/CycL/Ccl2/NrfF family%3B Contains 2 TPR repeats gene gene2236 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02237 VSVS12_02238 VSVS12_02238 VSVS12_02238 2456267 2456746 - Cytochrome c-type bioproteinis protein CcmH May be required for the biogenesis of c-type cytochromes. Possible subunit of a heme lyase. Belongs to the CcmH/CycL/Ccl2/NrfF family%3B Contains 2 TPR repeats gene gene2237 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02238 VSVS12_02239 VSVS12_02239 VSVS12_02239 2456746 2457297 - Thiol:disulfide interchange protein DsbE Involved in disulfide bond formation. Catalyzes a late%2C reductive step in the assembly of periplasmic c-type cytochromes%2C probably the reduction of disulfide bonds of the apocytochrome c to allow covalent linkage with the heme. Possible subunit of a heme lyase (By similarity)%3B Belongs to the thioredoxin family. DsbE subfamily%3B Contains 1 thioredoxin domain gene gene2238 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02239 VSVS12_02240 VSVS12_02240 VSVS12_02240 2457299 2459257 - Cytochrome c-type bioproteinis protein CcmF Required for the biogenesis of c-type cytochromes. Possible subunit of a heme lyase. Belongs to the CcmF/CycK/Ccl1/NrfE/CcsA family gene gene2239 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02240 VSVS12_02241 VSVS12_02241 VSVS12_02241 2459254 2459739 - Cytochrome c-type bioproteinis protein CcmE Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH%3B Belongs to the CcmE/CycJ family gene gene2240 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02241 VSVS12_02242 VSVS12_02242 VSVS12_02242 2459736 2459942 - Heme exporter protein D Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes%3B Belongs to the CcmD/CycX/HelD family gene gene2241 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02242 VSVS12_02243 VSVS12_02243 VSVS12_02243 2459945 2460709 - Heme exporter protein Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes%3B Belongs to the CcmC/CycZ/HelC family gene gene2242 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02243 VSVS12_02244 VSVS12_02244 VSVS12_02244 2460820 2461476 - Heme exporter protein Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes. Belongs to the CcmB/CycW/HelB family gene gene2243 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02244 VSVS12_02245 VSVS12_02245 VSVS12_02245 2461491 2462111 - Cytochrome c bioproteinis ATP-binding export protein CcmA Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochrome%3B once thought to export heme%2C this seems not to be the case%2C but its exact role is uncertain. Responsible for energy coupling to the transport system%3B Belongs to the ABC transporter superfamily. CcmA exporter (TC 3. A. 1. 107) family%3B Contains 1 ABC transporter domain gene gene2244 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02245 VSVS12_02246 VSVS12_02246 VSVS12_02246 2462328 2462828 - hypothetical protein gene gene2245 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02246 VSVS12_02247 VSVS12_02247 VSVS12_02247 2462828 2463322 - Chemotaxis protein CheW Involved in the transmission of sensory signals from the chemoreceptors to the flagellar motors%3B Contains 1 cheW-like domain gene gene2246 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02247 VSVS12_02248 VSVS12_02248 VSVS12_02248 2463359 2464459 - Translation initiation factor IF-2 One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex%3B Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily%3B Contains 1 tr-type G (guanine nucleotide-binding) domain gene gene2247 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02248 VSVS12_02249 VSVS12_02249 VSVS12_02249 2464452 2465228 - Sporulation initiation inhibitor protein Soj Inhibits the initiation of sporulation%2C Spo0J antagonizes this inhibition. Soj ultimately inhibits the activation (phosphorylation) of Spo0A. It is not required for chromosome partitioning (By similarity)%3B Belongs to the ParA family gene gene2248 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02249 VSVS12_02250 VSVS12_02250 cheB cheB 2465239 2466369 - Protein-glutamate methylesterase Involved in the modulation of the chemotaxis syste%3B catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR%3B Required for aerobic and anaerobic chemotaxis. Contains 1 cheB-type methylesterase domain%3B Contains 1 response regulatory domain%3B KEGG: psu:Psesu_1460 two-component system%2C chemotaxis family%2C response regulator CheB gene gene2249 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02250 VSVS12_02251 VSVS12_02251 cheA cheA 2466398 2468581 - Histidine kinase Involved in the transmission of sensory signals from the chemoreceptors to the flagellar motors. CheA is autophosphorylate%3B it can transfer its phosphate group to either CheB or CheY (By similarity)%3B Contains 1 cheW-like domain%3B Contains 1 histidine kinase domain%3B Contains 1 HPt domain%3B KEGG: vch:VC2063 two-component system%2C chemotaxis family%2C sensor kinase CheA gene gene2250 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02251 VSVS12_02252 VSVS12_02252 VSVS12_02252 2468591 2469313 - Protein phosphatase CheZ Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)%3B Belongs to the CheZ family gene gene2251 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02252 VSVS12_02253 VSVS12_02253 VSVS12_02253 2469359 2469739 - Chemotaxis protein Involved in the transmission of sensory signals from the chemoreceptors to the flagellar motors. In its active (phosphorylated or acetylated) form%2C CheY exhibits enhanced binding to a switch component%2C FliM%2C at the flagellar motor which induces a change from counterclockwise to clockwise flagellar rotation (By similarity)%3B Contains 1 response regulatory domain gene gene2252 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02253 VSVS12_02254 VSVS12_02254 VSVS12_02254 2469773 2470507 - RNA polymerase sigma factor WhiG Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. The level of this sigma factor may be crucial in determining the developmental fate of hyphae. Belongs to the sigma-70 factor family gene gene2253 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02254 VSVS12_02255 VSVS12_02255 VSVS12_02255 2470500 2471387 - Iron-sulfur cluster carrier protein Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP%3B In the N-terminal sectio%3B belongs to the MIP18 family%3B In the C-terminal sectio%3B belongs to the Mrp/NBP35 ATP-binding proteins family gene gene2254 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02255 VSVS12_02256 VSVS12_02256 VSVS12_02256 2471400 2472872 - Flagellar biosynthesis protein FlhF Necessary for flagellar biosynthesis. May be involved in translocation of the flagellum (By similarity)%3B Belongs to the GTP-binding SRP family gene gene2255 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02256 VSVS12_02257 VSVS12_02257 VSVS12_02257 2472933 2475029 - Flagellar biosynthesis protein FlhA Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH%2C may constitute the export apparatus of flagellin (By similarity)%3B Belongs to the FHIPEP (flagella/HR/invasion proteins export pore) family gene gene2256 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02257 VSVS12_02258 VSVS12_02258 VSVS12_02258 2475144 2475608 - hypothetical protein gene gene2257 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02258 VSVS12_02259 VSVS12_02259 VSVS12_02259 2475909 2478683 + Pitrilysin Can cleave insulin and TGF-alpha%3B Belongs to the peptidase M16 family%3B KEGG: pseo:OM33_19265 protease III gene gene2258 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02259 VSVS12_02260 VSVS12_02260 VSVS12_02260 2478707 2479303 - Protein YecM To H. influenzae HI_1582/HI_1581 gene gene2259 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02260 VSVS12_02261 VSVS12_02261 rarS rarS 2479515 2481248 + Arginine--tRNA ligase Belongs to the class-I aminoacyl-tRNA synthetase family%3B KEGG: vch:VC2074 arginyl-tRNA synthetase gene gene2260 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02261 VSVS12_02262 VSVS12_02262 VSVS12_02262 2482388 2482819 + hypothetical protein gene gene2261 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02262 VSVS12_02263 VSVS12_02263 VSVS12_02263 2482915 2483145 - hypothetical protein gene gene2262 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02263 VSVS12_02264 VSVS12_02264 VSVS12_02264 2483142 2485412 - Ferrous iron transport protein B Fe(2+) uptake system%2C probably driven by GTP%3B Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin- like GTPase superfamily. FeoB GTPase (TC 9. A. 8) family%3B Contains 1 FeoB-type G (guanine nucleotide-binding) domain gene gene2263 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02264 VSVS12_02265 VSVS12_02265 VSVS12_02265 2485412 2485639 - hypothetical protein gene gene2264 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02265 VSVS12_02266 VSVS12_02266 VSVS12_02266 2486678 2490052 - hypothetical protein gene gene2265 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02266 VSVS12_02267 VSVS12_02267 VSVS12_02267 2490203 2491081 - High-affinity zinc uptake system protein ZnuA Involved in the high-affinity zinc uptake transport system. Belongs to the bacterial solute-binding protein 9 family gene gene2266 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02267 VSVS12_02268 VSVS12_02268 znuC znuC 2491166 2491954 + Ribose import ATP-binding protein RbsA Part of the ABC transporter complex RbsABCD involved in ribose import. Responsible for energy coupling to the transport system%3B Belongs to the ABC transporter superfamily. Ribose importer (TC 3. A. 1. 2. 1) family%3B Contains 2 ABC transporter domains%3B KEGG: yin:CH53_3805 zinc transport system ATP-binding protein%3B Acting on acid anhydrides%3B catalyzing transmembrane movement of substances gene gene2267 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02268 VSVS12_02269 VSVS12_02269 VSVS12_02269 2491917 2492732 + putative membrane protein in ycf23-apcF intergenic region Belongs to the ABC-3 integral membrane protein family gene gene2268 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02269 VSVS12_02270 VSVS12_02270 purF purF 2492822 2494336 - Amidophosphoribosyltransferase Catalyzes the first step in hexosamine metabolism%2C converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source%3B Contains 1 glutamine amidotransferase type-2 domain%3B Contains 2 SIS domains%3B KEGG: plu:plu3167 amidophosphoribosyltransferase gene gene2269 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02270 VSVS12_02271 VSVS12_02271 VSVS12_02271 2494372 2494863 - Colicin V production protein like protein To E. coli CvpA gene gene2270 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02271 VSVS12_02272 VSVS12_02272 VSVS12_02272 2494926 2495477 - Cell division protein DedD Non-essential cell division protein that could be required for efficient cell constriction%3B Belongs to the DedD family%3B Contains 1 SPOR domain gene gene2271 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02272 VSVS12_02273 VSVS12_02273 folC folC 2495478 2496743 - Dihydrofolate synthase Conversion of folates to polyglutamate derivatives%3B Belongs to the folylpolyglutamate synthase family%3B KEGG: vcy:IX92_03655 dihydrofolate synthase / folylpolyglutamate synthase gene gene2272 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02273 VSVS12_02274 VSVS12_02274 accD accD 2496789 2497715 - Acetyl-CoA carboxylase Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA%3B Belongs to the AccD/PCCB family%3B KEGG: ype:YPO2768 acetyl-CoA carboxylase carboxyl transferase subunit beta gene gene2273 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02274 VSVS12_02275 VSVS12_02275 truA truA 2497935 2498729 - tRNA pseudouridine(38-40) synthase Formation of pseudouridine at positions 38%2C 39 and 40 in the anticodon stem and loop of transfer RNAs%3B Belongs to the tRNA pseudouridine synthase TruA family%3B KEGG: ype:YPO2766 tRNA pseudouridine38-40 synthase gene gene2274 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02275 VSVS12_02276 VSVS12_02276 VSVS12_02276 2498898 2503916 - Dentin sialophosphoprotein gene gene2275 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02276 VSVS12_02277 VSVS12_02277 VSVS12_02277 2504124 2505137 - Aspartate-semialdehyde dehydrogenase Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate%3B Belongs to the aspartate-semialdehyde dehydrogenase family%3B KEGG: vch:VC2107 aspartate-semialdehyde dehydrogenase gene gene2276 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02277 VSVS12_02278 VSVS12_02278 pdxB pdxB 2505134 2506270 - 4-phosphoerythronate dehydrogenase Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate%3B Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. PdxB subfamily%3B KEGG: seb:STM474_2469 erythronate-4-phosphate dehydrogenase gene gene2277 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02278 VSVS12_02279 VSVS12_02279 fabB fabB 2506612 2507823 - Beta-ketoacyl-[acyl-carrier-protein] synthase I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Specific for elongation from C-10 to unsaturated C-16 and C-18 fatty acids (By similarity)%3B Belongs to the beta-ketoacyl-ACP synthases family%3B KEGG: plu:plu3184 3-oxoacyl-(acyl-carrier-protein) synthase I gene gene2278 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02279 VSVS12_02280 VSVS12_02280 mnmC mnmC 2507952 2509964 + tRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34%2C followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34%2C to form mnm(5)s(2)U34%3B In the N-terminal sectio%3B belongs to the methyltransferase superfamily. tRNA (mnm(5)s(2)U34)- methyltransferase family%3B In the C-terminal sectio%3B belongs to the DAO family%3B KEGG: vch:VC2110 tRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein%3B tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase gene gene2279 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02280 VSVS12_02281 VSVS12_02281 VSVS12_02281 2510119 2510655 - hypothetical protein gene gene2280 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02281 VSVS12_02282 VSVS12_02282 VSVS12_02282 2510781 2511044 - uncharacterized protein gene gene2281 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02282 VSVS12_02283 VSVS12_02283 VSVS12_02283 2511154 2512131 - uncharacterized protein To E. coli YbeQ gene gene2282 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02283 VSVS12_02284 VSVS12_02284 VSVS12_02284 2512297 2514441 + hypothetical protein gene gene2283 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02284 VSVS12_02285 VSVS12_02285 VSVS12_02285 2514452 2514925 + hypothetical protein gene gene2284 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02285 VSVS12_02286 VSVS12_02286 VSVS12_02286 2515031 2515561 - Elongation factor P hydroxylase Is involved in the final hydroxylation step of the post- translational modification of translation elongation factor P (EF- P) on 'Lys-34'. Acts after beta-lysylation of 'Lys-34' by EpmA and EpmB. EpmC adds an oxygen atom to the C5 position of 'Lys-34' and does not modify the added beta-lysine%3B Belongs to the EpmC family gene gene2285 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02286 VSVS12_02287 VSVS12_02287 VSVS12_02287 2515795 2516418 + UPF0126 membrane protein Belongs to the UPF0126 family gene gene2286 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02287 VSVS12_02288 VSVS12_02288 aroC aroC 2516517 2517602 - Chorismate synthase Catalyzes the anti-1%2C4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate%2C which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system%3B Belongs to the chorismate synthase family%3B KEGG: eco:b2329 chorismate synthase gene gene2287 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02288 VSVS12_02289 VSVS12_02289 prmB prmB 2517792 2518724 - Ribosomal protein L3 N(5)-glutamine methyltransferase Specifically methylates the 50S ribosomal protein L3 on 'Gln-150'. Does not methylate the translation termination release factors RF1 and RF2%3B Belongs to the protein N5-glutamine methyltransferase family. PrmB subfamily%3B KEGG: eco:b2330 ribosomal protein L3 glutamine methyltransferase gene gene2288 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02289 VSVS12_02290 VSVS12_02290 VSVS12_02290 2518798 2519328 + UPF0115 protein Belongs to the UPF0115 family%3B Contains 1 Smr domain gene gene2289 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02290 VSVS12_02291 VSVS12_02291 VSVS12_02291 2520425 2521555 - Flagellar biosynthetic protein FlhB Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH%2C may constitute the export apparatus of flagellin. Belongs to the type III secretion exporter family gene gene2290 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02291 VSVS12_02292 VSVS12_02292 VSVS12_02292 2521577 2522359 - Flagellar biosynthetic protein FliR Role in flagellar biosynthesis. Belongs to the FliR/MopE/SpaR family gene gene2291 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02292 VSVS12_02293 VSVS12_02293 VSVS12_02293 2522368 2522637 - Flagellar biosynthetic protein FliQ Role in flagellar biosynthesis. Belongs to the FliQ/MopD/SpaQ family gene gene2292 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02293 VSVS12_02294 VSVS12_02294 VSVS12_02294 2522650 2523525 - Flagellar biosynthetic protein FliP Plays a role in the flagellum-specific transport system%3B Belongs to the FliP/MopC/SpaP family gene gene2293 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02294 VSVS12_02295 VSVS12_02295 VSVS12_02295 2523512 2523904 - Flagellar protein FliO Involved in flagellar biosynthesis and adherence. May have a role in assisting the proper localization of the various flagellar components and in the localization and assembly of the adhesin on the bacterial surface. Belongs to the FliO/MopB family gene gene2294 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02295 VSVS12_02296 VSVS12_02296 VSVS12_02296 2523908 2524318 - Flagellar motor switch protein FliN FliN is one of three proteins (FliG%2C FliN%2C FliM) that form the rotor-mounted switch complex (C ring)%2C located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins%2C in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity)%3B Belongs to the FliN/MopA/SpaO family gene gene2295 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02296 VSVS12_02297 VSVS12_02297 VSVS12_02297 2524342 2525388 - Flagellar motor switch protein FliM FliM is one of three proteins (FliG%2C FliN%2C FliM) that forms the rotor-mounted switch complex (C ring)%2C located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins%2C in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity)%3B Belongs to the FliM family gene gene2296 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02297 VSVS12_02298 VSVS12_02298 VSVS12_02298 2525397 2525894 - hypothetical protein gene gene2297 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02298 VSVS12_02299 VSVS12_02299 VSVS12_02299 2525944 2527692 - Flagellar hook-length control protein Controls the length of the flagellar hook. Belongs to the FliK family gene gene2298 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02299 VSVS12_02300 VSVS12_02300 VSVS12_02300 2527921 2528358 - hypothetical protein gene gene2299 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02300 VSVS12_02301 VSVS12_02301 fliI fliI 2528359 2529684 - H(+)-transporting two-sector ATPase Probable catalytic subunit of a protein translocase for flagellum-specific export%2C or a proton translocase involved in local circuits at the flagellum%3B Belongs to the ATPase alpha/beta chains family%3B KEGG: vsp:VS_0826 flagellum-specific ATP synthase gene gene2300 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02301 VSVS12_02302 VSVS12_02302 VSVS12_02302 2529684 2530484 - hypothetical protein gene gene2301 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02302 VSVS12_02303 VSVS12_02303 VSVS12_02303 2530511 2531566 - Flagellar motor switch protein FliG FliG is one of three proteins (FliG%2C FliN%2C FliM) that forms the rotor-mounted switch complex (C ring)%2C located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins%2C in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity)%3B Belongs to the FliG family gene gene2302 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02303 VSVS12_02304 VSVS12_02304 VSVS12_02304 2531559 2533304 - Flagellar M-ring protein The M ring may be actively involved in energy transduction%3B Belongs to the FliF family gene gene2303 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02304 VSVS12_02305 VSVS12_02305 VSVS12_02305 2533319 2533630 - Flagellar hook-basal body complex protein FliE Belongs to the FliE family gene gene2304 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02305 VSVS12_02306 VSVS12_02306 VSVS12_02306 2533729 2535135 - Alginate biosynthesis transcriptional regulatory protein AlgB Member of the two-component regulatory system AlgB/KinB involved in regulation of alginate biosynthesis genes. Positive regulator of the alginate biosynthetic gene AlgD. Contains 1 response regulatory domain%3B Contains 1 sigma-54 factor interaction domain gene gene2305 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02306 VSVS12_02307 VSVS12_02307 flrB flrB 2535137 2536171 - Histidine kinase Member of the two-component regulatory system PgtB/PgtA that regulates the inducible phosphoglycerate transport system. Activates PgtA by phosphorylation. Contains 1 HAMP domain%3B Contains 1 histidine kinase domain%3B KEGG: vcy:IX92_03485 two-component system%2C sensor histidine kinase FlrB gene gene2306 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02307 VSVS12_02308 VSVS12_02308 VSVS12_02308 2536302 2537768 - Anaerobic nitric oxide reductase transcription regulator NorR Required for the expression of anaerobic nitric oxide (NO) reductase%2C acts as a transcriptional activator for at least the norVW operon. Activation also requires sigma-54%3B Contains 1 sigma-54 factor interaction domain gene gene2307 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02308 VSVS12_02309 VSVS12_02309 VSVS12_02309 2538021 2538431 - Flagellar protein FliS Belongs to the FliS family gene gene2308 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02309 VSVS12_02310 VSVS12_02310 VSVS12_02310 2538444 2538767 - hypothetical protein gene gene2309 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02310 VSVS12_02311 VSVS12_02311 VSVS12_02311 2538751 2540790 - Flagellar hook-associated protein Required for the morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure%2C which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end (By similarity)%3B Belongs to the FliD family gene gene2310 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02311 VSVS12_02312 VSVS12_02312 VSVS12_02312 2540811 2541239 - Protein FlaG To FlaG in other Vibrio species gene gene2311 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02312 VSVS12_02313 VSVS12_02313 VSVS12_02313 2541314 2542447 - Flagellin Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella. FlaA is required to form a core or scaffold into which the other flagellins are inserted to provide structural integrity. Essential for flagellar synthesis and motilit%3B important for full virulence. Belongs to the bacterial flagellin family gene gene2312 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02313 VSVS12_02314 VSVS12_02314 VSVS12_02314 2542689 2543831 - Flagellin Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella. FlaA is required to form a core or scaffold into which the other flagellins are inserted to provide structural integrity. Essential for flagellar synthesis and motilit%3B important for full virulence. Belongs to the bacterial flagellin family gene gene2313 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02314 VSVS12_02315 VSVS12_02315 VSVS12_02315 2544135 2545268 - Flagellin Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella. FlaA is essential for flagellar synthesis and full motility. Important for virulence at two different levels: is needed for crossing the fish integument and may play a role once the bacterium has entered the host. Belongs to the bacterial flagellin family gene gene2314 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02315 VSVS12_02316 VSVS12_02316 VSVS12_02316 2545413 2546315 - putative deferrochelatase/peroxidase YfeX Involved in the recovery of exogenous heme iron. Extracts iron from heme while preserving the tetrapyrrol ring intact%3B Belongs to the DyP-type peroxidase family gene gene2315 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02316 VSVS12_02317 VSVS12_02317 VSVS12_02317 2546384 2546848 - Inner membrane protein YfeZ gene gene2316 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02317 VSVS12_02318 VSVS12_02318 VSVS12_02318 2546999 2547472 - Formate-dependent nitrite reductase complex bifunctional subunit NrfFG Possible subunit of a heme lyase%3B Belongs to the CcmH/CycL/Ccl2/NrfF family%3B Contains 2 TPR repeats gene gene2317 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02318 VSVS12_02319 VSVS12_02319 VSVS12_02319 2547485 2548009 - Thiol:disulfide interchange protein Involved in disulfide bond formation. Catalyzes a late%2C reductive step in the assembly of periplasmic c-type cytochromes%2C probably the reduction of disulfide bonds of the apocytochrome c to allow covalent linkage with the heme. Possible subunit of a heme lyase (By similarity)%3B Belongs to the thioredoxin family. DsbE subfamily%3B Contains 1 thioredoxin domain gene gene2318 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02319 VSVS12_02320 VSVS12_02320 VSVS12_02320 2547987 2549906 - Cytochrome c-type bioproteinis protein CcmF Required for the biogenesis of c-type cytochromes. Possible subunit of a heme lyase. Belongs to the CcmF/CycK/Ccl1/NrfE/CcsA family gene gene2319 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02320 VSVS12_02321 VSVS12_02321 VSVS12_02321 2549910 2550881 - hypothetical protein Probably involved in the transfer of electrons from the quinone pool to the type-c cytochromes. Belongs to the NrfD family gene gene2320 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02321 VSVS12_02322 VSVS12_02322 VSVS12_02322 2550878 2551573 - Polysulfide reductase chain Component of the phosphorylative electron transport system with polysulfide as the terminal acceptor. Contains 3 4Fe-4S ferredoxin-type domains gene gene2321 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02322 VSVS12_02323 VSVS12_02323 VSVS12_02323 2551575 2552162 - Cytochrome c-type protein NrfB Plays a role in nitrite reduction gene gene2322 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02323 VSVS12_02324 VSVS12_02324 nrfA nrfA 2552651 2554078 + Nitrite reductase (cytochrome%3B ammonia-forming) Catalyzes the reduction of nitrite to ammonia%2C consuming six electrons in the process%3B Belongs to the cytochrome c-552 family%3B KEGG: vfi:VF_1554 nitrite reductase (cytochrome c-552) gene gene2323 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02324 VSVS12_02325 VSVS12_02325 VSVS12_02325 2554218 2554757 - Formate-dependent nitrite reductase complex subunit Required for formate-dependent nitrite reduction. Not required for the biosynthesis of any of the c-type cytochromes nor for the secretion of the periplasmic cytochromes. Contains 2 TPR repeats gene gene2324 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02325 VSVS12_02326 VSVS12_02326 VSVS12_02326 2554848 2555195 + hypothetical protein gene gene2325 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02326 VSVS12_02327 VSVS12_02327 VSVS12_02327 2555176 2555535 + hypothetical protein gene gene2326 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02327 VSVS12_02328 VSVS12_02328 VSVS12_02328 2555662 2555949 - hypothetical protein gene gene2327 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02328 VSVS12_02329 VSVS12_02329 VSVS12_02329 2556149 2556496 + Arsenate reductase (glutaredoxin) Belongs to the ArsC family%3B KEGG: pre:PCA10_45380 arsenate reductase gene gene2328 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02329 VSVS12_02330 VSVS12_02330 dapE dapE 2556524 2557657 + Succinyl-diaminopimelate desuccinylase Catalyzes the hydrolysis of N-succinyl-L%2CL- diaminopimelic acid (SDAP)%2C forming succinate and LL-2%2C6- diaminoheptanedioate (DAP)%2C an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid%2C an essential component of bacterial cell walls%3B Belongs to the peptidase M20A family. DapE subfamily%3B KEGG: vch:VC2152 succinyl-diaminopimelate desuccinylase gene gene2329 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02330 VSVS12_02331 VSVS12_02331 VSVS12_02331 2557654 2558340 + uncharacterized protein gene gene2330 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02331 VSVS12_02332 VSVS12_02332 VSVS12_02332 2558340 2558528 + hypothetical protein gene gene2331 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02332 VSVS12_02333 VSVS12_02333 VSVS12_02333 2558617 2559393 - uncharacterized protein gene gene2332 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02333 VSVS12_02334 VSVS12_02334 VSVS12_02334 2559396 2559941 - Protein Syd Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY%2C thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function%3B Belongs to the Syd family gene gene2333 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02334 VSVS12_02335 VSVS12_02335 queF queF 2560019 2560864 + PreQ(1) synthase Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)%3B Belongs to the GTP cyclohydrolase I family. QueF type 2 subfamily%3B KEGG: vch:VC0902 7-cyano-7-deazaguanine reductase gene gene2334 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02335 VSVS12_02336 VSVS12_02336 VSVS12_02336 2560879 2563149 + hypothetical protein gene gene2335 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02336 VSVS12_02337 VSVS12_02337 VSVS12_02337 2563262 2564827 + Diguanylate cyclase DosC Globin-coupled heme-based oxygen sensor protein displaying diguanylate cyclase (DGC) activity in response to oxygen availability. Thus%2C catalyzes the synthesis of cyclic diguanylate (c-di-GMP) via the condensation of 2 GTP molecules. Cyclic-di-GMP is a second messenger which controls cell surface- associated traits in bacteria (By similarity)%3B Contains 1 GGDEF domain gene gene2336 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02337 VSVS12_02338 VSVS12_02338 VSVS12_02338 2565109 2566476 + LOG family protein Belongs to the LOG family gene gene2337 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02338 VSVS12_02339 VSVS12_02339 VSVS12_02339 2566571 2567350 + Flap endonuclease Xni Has flap endonuclease activity%3B Belongs to the Xni family%3B Contains 1 5'-3' exonuclease domain gene gene2338 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02339 VSVS12_02340 VSVS12_02340 VSVS12_02340 2567455 2568786 - Transposase InsG for insertion sequence element IS4 Involved in the transposition of the insertion sequence IS4. Belongs to the transposase 11 family gene gene2339 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02340 VSVS12_02341 VSVS12_02341 rlmM rlmM 2568941 2570032 - 23S rRNA (cytidine(2498)-2'-O)-methyltransferase Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA%3B Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily%3B KEGG: sgl:SG1954 23S rRNA (cytidine2498-2'-O)-methyltransferase gene gene2340 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02341 VSVS12_02342 VSVS12_02342 VSVS12_02342 2570033 2570428 - Proline--tRNA ligase Belongs to the UPF0382 family%3B KEGG: gsl:Gasu_24190 prolyl-tRNA synthetase gene gene2341 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02342 VSVS12_02343 VSVS12_02343 VSVS12_02343 2570430 2571062 - hypothetical protein gene gene2342 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02343 VSVS12_02344 VSVS12_02344 VSVS12_02344 2571052 2571966 - Glycine cleavage system transcriptional activator Regulatory protein for the glycine cleavage system operon (gcv). Mediates activation of gcv by glycine and repression by purines. GcvA is negatively autoregulated. Binds to three sites upstream of the gcv promoter (By similarity)%3B Contains 1 HTH lysR-type DNA-binding domain gene gene2343 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02344 VSVS12_02345 VSVS12_02345 VSVS12_02345 2572516 2572830 + hypothetical protein gene gene2344 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02345 VSVS12_02346 VSVS12_02346 VSVS12_02346 2573397 2573687 + Putative transposase InsK for insertion sequence element IS150 Involved in the transposition of the insertion sequence IS150. Belongs to the transposase IS3/IS150/IS904 family%3B Contains 1 integrase catalytic domain gene gene2345 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02346 VSVS12_02347 VSVS12_02347 VSVS12_02347 2573892 2575340 - tRNA sulfurtransferase Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs%2C which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS%2C forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole%2C in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS%3B Belongs to the ThiI family%3B Contains 1 rhodanese domain%3B Contains 1 THUMP domain gene gene2346 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02347 VSVS12_02348 VSVS12_02348 VSVS12_02348 2575503 2576450 - uncharacterized protein May be involved in some transport function. Belongs to the MotB family%3B Contains 1 OmpA-like domain gene gene2347 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02348 VSVS12_02349 VSVS12_02349 VSVS12_02349 2576463 2577224 - Motility protein MotA and MotB comprise the stator element of the flagellar motor complex. Required for rotation of the flagellar motor. Probable transmembrane proton channel (By similarity)%3B Belongs to the MotA family gene gene2348 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02349 VSVS12_02350 VSVS12_02350 xseB xseB 2577522 2577764 + Exodeoxyribonuclease VII Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides%2C which are then degraded further into small acid-soluble oligonucleotides%3B Belongs to the XseB family%3B KEGG: vch:VC0891 exodeoxyribonuclease VII small subunit gene gene2349 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02350 VSVS12_02351 VSVS12_02351 ispA ispA 2577785 2578669 + Dimethylallyltranstransferase Belongs to the FPP/GGPP synthase family%3B KEGG: vch:VC0890 farnesyl diphosphate synthase gene gene2350 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02351 VSVS12_02352 VSVS12_02352 VSVS12_02352 2578690 2580555 + 1-deoxy-D-xylulose-5-phosphate synthase Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)%3B Belongs to the transketolase family. DXPS subfamily%3B KEGG: ype:YPO3177 1-deoxy-D-xylulose-5-phosphate synthase gene gene2351 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02352 VSVS12_02353 VSVS12_02353 VSVS12_02353 2580638 2581303 - ToxR-activated A lipoprotein Contains 1 fibronectin type-III domain%3B Contains 1 peptidase M66 domain gene gene2352 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02353 VSVS12_02354 VSVS12_02354 VSVS12_02354 2581291 2581662 - hypothetical protein gene gene2353 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02354 VSVS12_02355 VSVS12_02355 VSVS12_02355 2581659 2583608 - hypothetical protein gene gene2354 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02355 VSVS12_02356 VSVS12_02356 truC truC 2583929 2584651 - tRNA pseudouridine(65) synthase Responsible for synthesis of pseudouridine from uracil- 65 in transfer RNAs%3B Belongs to the pseudouridine synthase RluA family%3B KEGG: eco:b2791 tRNA pseudouridine65 synthase gene gene2355 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02356 VSVS12_02357 VSVS12_02357 VSVS12_02357 2584652 2584966 - tRNA pseudouridine(65) synthase Responsible for synthesis of pseudouridine from uracil- 65 in transfer RNAs%3B In the C-terminal sectio%3B belongs to the pseudouridine synthase RluA family%3B To E. coli YqcC in the N-terminal section%3B KEGG: aao:ANH9381_1783 tRNA pseudouridine65 synthase gene gene2356 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02357 VSVS12_02358 VSVS12_02358 VSVS12_02358 2585043 2586080 + hypothetical protein gene gene2357 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02358 VSVS12_02359 VSVS12_02359 VSVS12_02359 2586095 2586394 + hypothetical protein gene gene2358 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02359 VSVS12_02360 VSVS12_02360 VSVS12_02360 2586342 2586905 - Ribosomal-protein-alanine N-acetyltransferase KEGG: ddh:Desde_1483 ribosomal-protein-alanine N-acetyltransferase gene gene2359 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02360 VSVS12_02361 VSVS12_02361 VSVS12_02361 2587751 2588032 + hypothetical protein gene gene2360 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02361 VSVS12_02362 VSVS12_02362 sucD sucD 2588176 2589048 - Succinate--CoA ligase (ADP-forming) Belongs to the succinate/malate CoA ligase alpha subunit family%3B KEGG: eco:b0729 succinyl-CoA synthetase alpha subunit%3B overlaps another CDS with the same product name gene gene2361 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02362 VSVS12_02363 VSVS12_02363 sucC sucC 2589048 2590214 - Succinate--CoA ligase (ADP-forming) Belongs to the succinate/malate CoA ligase beta subunit family%3B Contains 1 ATP-grasp domain%3B KEGG: eco:b0728 succinyl-CoA synthetase beta subunit%3B overlaps another CDS with the same product name gene gene2362 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02363 VSVS12_02364 VSVS12_02364 dlsT dlsT 2590412 2591617 - Dihydrolipoyllysine-residue succinyltransferase The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2- oxoglutarate dehydrogenase (E1)%2C dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity)%3B Belongs to the 2-oxoacid dehydrogenase family%3B Contains 1 lipoyl-binding domain%3B KEGG: hin:HI1661 2-oxoglutarate dehydrogenase E2 component (dihydrolipoamide succinyltransferase) gene gene2363 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02364 VSVS12_02365 VSVS12_02365 ogdH ogdH 2591629 2594484 - Oxoglutarate dehydrogenase (succinyl-transferring) The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2- oxoglutarate dehydrogenase (E1)%2C dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity)%3B Belongs to the alpha-ketoglutarate dehydrogenase family%3B KEGG: vch:VC2087 2-oxoglutarate dehydrogenase E1 component gene gene2364 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02365 VSVS12_02366 VSVS12_02366 sdhB sdhB 2594583 2595296 - Succinate dehydrogenase (quinone) Two distinct%2C membrane-bound%2C FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversio%3B the fumarate reductase is used in anaerobic growth%2C and the succinate dehydrogenase is used in aerobic growth. Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family%3B Contains 1 2Fe-2S ferredoxin-type domain%3B Contains 1 4Fe-4S ferredoxin-type domain%3B KEGG: sty:STY0778 succinate dehydrogenase / fumarate reductase%2C iron-sulfur subunit gene gene2365 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02366 VSVS12_02367 VSVS12_02367 sdhA sdhA 2595307 2597073 - Succinate dehydrogenase (quinone) Two distinct%2C membrane-bound%2C FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversio%3B the fumarate reductase is used in anaerobic growth%2C and the succinate dehydrogenase is used in aerobic growth%3B Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily%3B KEGG: eco:b0723 succinate dehydrogenase / fumarate reductase%2C flavoprotein subunit gene gene2366 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02367 VSVS12_02368 VSVS12_02368 VSVS12_02368 2597074 2597418 - Succinate dehydrogenase hydrophobic membrane anchor subunit Membrane-anchoring subunit of succinate dehydrogenase (SDH) gene gene2367 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02368 VSVS12_02369 VSVS12_02369 VSVS12_02369 2597412 2597792 - Succinate dehydrogenase cytochrome b556 subunit Membrane-anchoring subunit of succinate dehydrogenase (SDH)%3B Belongs to the cytochrome b560 family gene gene2368 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02369 VSVS12_02370 VSVS12_02370 gltA gltA 2598200 2599489 + Citrate (Si)-synthase Belongs to the citrate synthase family%3B KEGG: yel:LC20_01675 citrate synthase gene gene2369 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02370 VSVS12_02371 VSVS12_02371 VSVS12_02371 2599834 2600592 - GTP cyclohydrolase 1 type 2 like protein Belongs to the GTP cyclohydrolase I type 2/NIF3 family gene gene2370 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02371 VSVS12_02372 VSVS12_02372 VSVS12_02372 2600696 2601448 + hypothetical protein gene gene2371 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02372 VSVS12_02373 VSVS12_02373 VSVS12_02373 2601637 2601801 + hypothetical protein gene gene2372 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02373 VSVS12_02374 VSVS12_02374 VSVS12_02374 2601782 2603428 - Phosphoglucomutase (alpha-D-glucose-1%2C6-bisphosphate-dependent) This enzyme participates in both the breakdown and synthesis of glucose%3B Belongs to the phosphohexose mutase family%3B KEGG: xbo:XBJ1_1074 phosphoglucomutase gene gene2373 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02374 VSVS12_02375 VSVS12_02375 VSVS12_02375 2603510 2604049 - Negative modulator of initiation of replication Negative regulator of replication initiation%2C which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region%2C thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated%3B Belongs to the SeqA family gene gene2374 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02375 VSVS12_02376 VSVS12_02376 ybfF ybfF 2604143 2604907 + Esterase Displays esterase activity toward palmitoyl-CoA%2C malonyl-CoA and pNP-butyrate%3B Belongs to the DmpD/TodF/XylF esterase family%3B KEGG: vsp:VS_2254 esterase%3B Acting on ester bonds gene gene2375 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02376 VSVS12_02377 VSVS12_02377 VSVS12_02377 2605100 2605321 + hypothetical protein gene gene2376 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02377 VSVS12_02378 VSVS12_02378 VSVS12_02378 2605370 2605903 + Flavodoxin Low-potential electron donor to a number of redox enzymes%3B Belongs to the flavodoxin family%3B Contains 1 flavodoxin-like domain gene gene2377 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02378 VSVS12_02379 VSVS12_02379 VSVS12_02379 2605952 2606446 - hypothetical protein gene gene2378 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02379 VSVS12_02380 VSVS12_02380 VSVS12_02380 2606645 2607091 + Ferric uptake regulation protein Acts as a global negative controlling element%2C employing Fe(2+) as a cofactor to bind the operator of the repressed genes. Regulates the expression of several outer-membrane proteins including the iron transport operon (By similarity)%3B Belongs to the Fur family gene gene2379 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02380 VSVS12_02381 VSVS12_02381 qarS qarS 2607199 2608869 - Glutamine--tRNA ligase Belongs to the class-I aminoacyl-tRNA synthetase family%3B KEGG: eco:b0680 glutaminyl-tRNA synthetase gene gene2380 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02381 VSVS12_02382 VSVS12_02382 VSVS12_02382 2609117 2610691 - Protein-N(pi)-phosphohistidine--sugar phosphotransferase The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS)%2C a major carbohydrate active -transport system%2C catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in N-acetylglucosamine transport. Contains 1 PTS EIIA type-1 domain%3B Contains 1 PTS EIIB type-1 domain%3B Contains 1 PTS EIIC type-1 domain%3B KEGG: vch:VC0995 PTS system%2C N-acetylglucosamine-specific IIB component gene gene2381 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02382 VSVS12_02383 VSVS12_02383 nagA nagA 2611176 2612312 + N-acetylglucosamine-6-phosphate deacetylase Involved in the first committed step in the biosynthesis of amino-sugar-nucleotides. Catalyzes the hydrolysis of the N- acetyl group of N-acetylglucosamine-6-phosphate (GlcNAc-6-P) to yield glucosamine 6-phosphate and acetate%3B Belongs to the NagA family%3B KEGG: srr:SerAS9_1198 N-acetylglucosamine-6-phosphate deacetylase gene gene2382 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02383 VSVS12_02384 VSVS12_02384 VSVS12_02384 2612315 2613529 + N-acetylglucosamine repressor Acts as a repressor of the nagEBACD operon and acts both as an activator and a repressor for the transcription of the glmSU operon%3B Belongs to the ROK (NagC/XylR) family gene gene2383 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02384 VSVS12_02385 VSVS12_02385 VSVS12_02385 2613616 2615202 + K(+) efflux antiporter 3%2C chloroplastic Electroneutral K(+)/H(+) antiporter. Accelerates photosynthetic acclimation in fluctuating light environments%3B Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2. A. 37) family. KEA (TC 2. A. 37. 1) subfamily%3B Contains 1 RCK N-terminal domain gene gene2384 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02385 VSVS12_02386 VSVS12_02386 asnB asnB 2615410 2617074 + Asparagine synthase (glutamine-hydrolyzing) Catalyzes the ATP-dependent conversion of aspartate into asparagine%2C using glutamine as a source of nitrogen. Can also use ammonia as the nitrogen source in vitro%2C albeit with lower efficiency. As nucleotide substrates%2C ATP and dATP are utilized at a similar rate in both the glutamine- and ammonia-dependent reactions%2C whereas GTP utilization is only 15%25 that of ATP%2C and CTP%2C UTP%2C ITP and XTP are very poor or not substrates. Also exhibits glutaminase activity%3B Belongs to the asparagine synthetase family%3B Contains 1 glutamine amidotransferase type-2 domain%3B KEGG: ype:YPO2623 asparagine synthase (glutamine-hydrolysing) gene gene2385 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02386 VSVS12_02387 VSVS12_02387 VSVS12_02387 2617364 2618755 + putative transporter YclF Belongs to the PTR2/POT transporter (TC 2. A. 17) family gene gene2386 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02387 VSVS12_02388 VSVS12_02388 VSVS12_02388 2619024 2619893 + hypothetical protein gene gene2387 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02388 VSVS12_02389 VSVS12_02389 VSVS12_02389 2620056 2620132 - tRNA-Pro tRNA gene2388 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02389 VSVS12_02390 VSVS12_02390 VSVS12_02390 2620389 2620529 + hypothetical protein gene gene2389 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02390 VSVS12_02391 VSVS12_02391 VSVS12_02391 2620760 2621341 + putative DNA endonuclease SmrA Has DNA endonuclease activity. Binds DNA%3B Contains 1 Smr domain gene gene2390 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02391 VSVS12_02392 VSVS12_02392 rluF rluF 2621434 2622579 + 23S rRNA pseudouridine(2604) synthase Responsible for synthesis of pseudouridine from uracil- 2604 in 23S ribosomal RNA%3B Belongs to the pseudouridine synthase RsuA family%3B Contains 1 S4 RNA-binding domain%3B KEGG: vvu:VV1_0246 23S rRNA pseudouridine2604 synthase gene gene2391 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02392 VSVS12_02393 VSVS12_02393 uprT uprT 2622801 2623427 - Uracil phosphoribosyltransferase Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate%3B Belongs to the UPRTase family%3B KEGG: eco:b2498 uracil phosphoribosyltransferase gene gene2392 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02393 VSVS12_02394 VSVS12_02394 purM purM 2623608 2624648 + Phosphoribosylformylglycinamidine cyclo-ligase Belongs to the AIR synthase family%3B KEGG: vch:VC2226 phosphoribosylformylglycinamidine cyclo-ligase gene gene2393 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02394 VSVS12_02395 VSVS12_02395 purN purN 2624651 2625292 + Phosphoribosylglycinamide formyltransferase Belongs to the GART family%3B KEGG: dze:Dd1591_2993 phosphoribosylglycinamide formyltransferase 1 gene gene2394 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02395 VSVS12_02396 VSVS12_02396 VSVS12_02396 2625630 2626289 + Inner membrane protein YebE gene gene2395 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02396 VSVS12_02397 VSVS12_02397 VSVS12_02397 2626423 2626632 + UPF0253 protein Belongs to the UPF0253 family gene gene2396 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02397 VSVS12_02398 VSVS12_02398 VSVS12_02398 2626635 2626826 + hypothetical protein gene gene2397 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02398 VSVS12_02399 VSVS12_02399 VSVS12_02399 2626900 2627241 - hypothetical protein gene gene2398 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02399 VSVS12_02400 VSVS12_02400 purL purL 2627698 2631609 - Phosphoribosylformylglycinamidine synthase Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate%3B In the N-terminal sectio%3B belongs to the FGAMS family%3B Contains 1 glutamine amidotransferase type-1 domain%3B KEGG: eco:b2557 phosphoribosylformylglycinamidine synthase gene gene2399 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02400 VSVS12_02401 VSVS12_02401 VSVS12_02401 2631903 2633468 + Membrane-bound lytic murein transglycosylase Murein-degrading enzyme that degrades murein glycan strands and insoluble%2C high-molecular weight murein sacculi%2C with the concomitant formation of a 1%2C6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella%3B In the N-terminal sectio%3B belongs to the bacterial solute-binding protein 3 family%3B In the C-terminal sectio%3B belongs to the transglycosylase Slt family gene gene2400 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02401 VSVS12_02402 VSVS12_02402 VSVS12_02402 2633751 2633885 + hypothetical protein gene gene2401 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02402 VSVS12_02403 VSVS12_02403 tadA tadA 2633979 2634560 - tRNA(adenine(34)) deaminase Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2)%3B Belongs to the cytidine and deoxycytidylate deaminase family%3B Contains 1 CMP/dCMP-type deaminase domain%3B KEGG: fsu:Fisuc_3025 tRNA(adenine34) deaminase gene gene2402 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02403 VSVS12_02404 VSVS12_02404 VSVS12_02404 2634644 2635924 - UPF0053 protein Belongs to the UPF0053 family%3B Contains 2 CBS domains%3B Contains 1 DUF21 domain gene gene2403 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02404 VSVS12_02405 VSVS12_02405 VSVS12_02405 2636052 2637611 - p-aminobenzoyl-glutamate transport protein Essential for aminobenzoyl-glutamate utilization. It catalyzes the concentration-dependent uptake of p-aminobenzoyl- glutamate (PABA-GLU) into the cell and allows accumulation of PABA-GLU to a concentration enabling AbgAB to catalyze cleavage into p-aminobenzoate and glutamate. It seems also to increase the sensitivity to low levels of aminobenzoyl-glutamate. May actually serve physiologically as a transporter for some other molecule%2C perhaps a dipeptide%2C and that it transports p-aminobenzoyl- glutamate as a secondary activity. The physiological role of abgABT should be clarified gene gene2404 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02405 VSVS12_02406 VSVS12_02406 VSVS12_02406 2637863 2638387 - hypothetical protein gene gene2405 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02406 VSVS12_02407 VSVS12_02407 VSVS12_02407 2638335 2638850 - hypothetical protein gene gene2406 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02407 VSVS12_02408 VSVS12_02408 VSVS12_02408 2638847 2639485 - hypothetical protein gene gene2407 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02408 VSVS12_02409 VSVS12_02409 VSVS12_02409 2639463 2639972 - hypothetical protein gene gene2408 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02409 VSVS12_02410 VSVS12_02410 VSVS12_02410 2640100 2640519 + hypothetical protein gene gene2409 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02410 VSVS12_02411 VSVS12_02411 VSVS12_02411 2640629 2641777 - Chaperone protein DnaJ Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins%2C also in an autonomous%2C DnaK-independent fashion. Unfolded proteins bind initially to Dna%3B upon interaction with the DnaJ-bound protein%2C DnaK hydrolyzes its bound ATP%2C resulting in the formation of a stable complex. GrpE releases ADP from Dna%3B ATP binding to DnaK triggers the release of the substrate protein%2C thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ%2C DnaK and GrpE are required for fully efficient folding. Also involved%2C together with DnaK and GrpE%2C in the DNA replication of plasmids through activation of initiation proteins%3B Belongs to the DnaJ family%3B Contains 1 CR-type zinc finger%3B Contains 1 J domain gene gene2410 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02411 VSVS12_02412 VSVS12_02412 VSVS12_02412 2642062 2643975 - Chaperone protein DnaK Acts as a chaperone%3B Belongs to the heat shock protein 70 family gene gene2411 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02412 VSVS12_02413 VSVS12_02413 VSVS12_02413 2644236 2644526 - Putative transposase InsK for insertion sequence element IS150 Involved in the transposition of the insertion sequence IS150. Belongs to the transposase IS3/IS150/IS904 family%3B Contains 1 integrase catalytic domain gene gene2412 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02413 VSVS12_02414 VSVS12_02414 VSVS12_02414 2645093 2645407 - hypothetical protein gene gene2413 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02414 VSVS12_02415 VSVS12_02415 VSVS12_02415 2645561 2645908 + hypothetical protein gene gene2414 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02415 VSVS12_02416 VSVS12_02416 VSVS12_02416 2646110 2647387 - C4-dicarboxylate transport protein Responsible for the transport of dicarboxylates such as succinate%2C fumarate%2C and malate from the periplasm across the membrane%3B Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2. A. 23) family gene gene2415 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02416 VSVS12_02417 VSVS12_02417 VSVS12_02417 2647658 2647960 + hypothetical protein gene gene2416 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02417 VSVS12_02418 VSVS12_02418 VSVS12_02418 2647821 2648426 - Protein GrpE Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins%2C in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to Dna%3B upon interaction with the DnaJ-bound protein%2C DnaK hydrolyzes its bound ATP%2C resulting in the formation of a stable complex. GrpE releases ADP from Dna%3B ATP binding to DnaK triggers the release of the substrate protein%2C thus completing the reaction cycle. Several rounds of ATP- dependent interactions between DnaJ%2C DnaK and GrpE are required for fully efficient folding%3B Belongs to the GrpE family gene gene2417 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02418 VSVS12_02419 VSVS12_02419 ppnK ppnK 2648572 2649456 + NAD(+) kinase Involved in the regulation of the intracellular balance of NAD and NADP%2C and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP%3B Belongs to the NAD kinase family%3B KEGG: vch:VC0853 NAD+ kinase gene gene2418 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02419 VSVS12_02420 VSVS12_02420 VSVS12_02420 2649610 2649738 - hypothetical protein gene gene2419 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02420 VSVS12_02421 VSVS12_02421 VSVS12_02421 2650042 2651706 + DNA repair protein RecN May be involved in recombinational repair of damaged DNA%3B Belongs to the RecN family gene gene2420 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02421 VSVS12_02422 VSVS12_02422 VSVS12_02422 2651835 2652218 + Outer membrane protein assembly factor BamE Part of the outer membrane protein assembly complex%2C which is involved in assembly and insertion of beta-barrel proteins into the outer membrane%3B Belongs to the BamE family gene gene2421 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02422 VSVS12_02423 VSVS12_02423 VSVS12_02423 2652294 2652647 - UPF0125 protein Belongs to the UPF0125 (RnfH) family gene gene2422 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02423 VSVS12_02424 VSVS12_02424 VSVS12_02424 2652637 2653080 - Persistence and stress-resistance toxin PasT Toxic component of a toxin-antitoxin (TA) module. Binds to 50S ribosomal subunits%2C preventing them from associating with 30S subunits to form 70S ribosomes (By similarity). In this strain of E. coli low levels of PasT complement operon disruption%2C however high levels are toxi%3B their effects are abrogated by high level expression of cognate antitoxin PasI. Plays a role in persistence after antibiotic exposure and survival of nitrosative stres%3B the toxic and persistence phenotypes are conferred by the same N- terminal region of the protein%2C while the stress resistance effects can be uncoupled from them in deletion mutants%3B Belongs to the ribosome association toxin RatA family gene gene2423 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02424 VSVS12_02425 VSVS12_02425 VSVS12_02425 2653199 2653684 + SsrA-binding protein Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA)%2C required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape%2C replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gen%3B the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide'%2C a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA%2C entering the A-site of stalled ribosomes%2C displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRN%3B the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation%2C which seems to be the essential function of trans- translation%3B Belongs to the SmpB family gene gene2424 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02425 VSVS12_02426 VSVS12_02426 mcrA mcrA 2654400 2655260 + 5-methylcytosine-specific restriction enzyme Restriction of 5-methyl and 5-hydroxymethylcytosines at the specific DNA sequence C(me)CGG. Contains 1 HNH domain%3B KEGG: ssp:SSP0073 5-methylcytosine-specific restriction enzyme A%3B Endodeoxyribonucleases producing 5'-phosphomonoesters gene gene2425 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02426 VSVS12_02427 VSVS12_02427 VSVS12_02427 2655510 2656775 + Miniconductance mechanosensitive channel YbdG Mechanosensitive channel of miniconductance that confers protection against mild hypoosmotic shock. Overexpression confers protection against severe shocks%3B Belongs to the MscS (TC 1. A. 23) family gene gene2426 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02427 VSVS12_02428 VSVS12_02428 VSVS12_02428 2656879 2657760 - hypothetical protein gene gene2427 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02428 VSVS12_02429 VSVS12_02429 VSVS12_02429 2658056 2659468 - S-methyl-5'-thioadenosine deaminase Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine%2C respectively. Is also able to deaminate adenosine%3B Belongs to the MTA/SAH deaminase family%3B KEGG: ctm:Cabther_A2117 5-methylthioadenosine/S-adenosylhomocysteine deaminase gene gene2428 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02429 VSVS12_02430 VSVS12_02430 VSVS12_02430 2659765 2660058 + hypothetical protein gene gene2429 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02430 VSVS12_02431 VSVS12_02431 VSVS12_02431 2660296 2661831 + Hydrolase YhcX Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family%3B Contains 1 CN hydrolase domain%3B Contains 1 N-acetyltransferase domain gene gene2430 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02431 VSVS12_02432 VSVS12_02432 VSVS12_02432 2661876 2663870 - Flagellar attachment zone protein A component of FAZ filament that is required for correct FAZ assembly and attachment. Not essential for new flagellum growth gene gene2431 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02432 VSVS12_02433 VSVS12_02433 VSVS12_02433 2664605 2665963 + uncharacterized protein gene gene2432 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02433 VSVS12_02434 VSVS12_02434 VSVS12_02434 2665945 2666043 - hypothetical protein gene gene2433 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02434 VSVS12_02435 VSVS12_02435 gamP gamP 2666169 2667680 - Protein-N(pi)-phosphohistidine--sugar phosphotransferase The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS)%2C a major carbohydrate active -transport system%2C catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in glucose transport (By similarity)%3B Contains 1 PTS EIIA type-1 domain%3B Contains 1 PTS EIIB type-1 domain%3B Contains 1 PTS EIIC type-1 domain%3B KEGG: vni:VIBNI_A0269 PTS system%2C D-glucosamine-specific IIA component gene gene2434 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02435 VSVS12_02436 VSVS12_02436 VSVS12_02436 2667924 2668853 - Inner membrane protein YedI gene gene2435 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02436 VSVS12_02437 VSVS12_02437 metY metY 2668986 2670254 - O-acetylhomoserine aminocarboxypropyltransferase Transforms O-acetylhomoserine into homocysteine. Belongs to the trans-sulfuration enzymes family%3B KEGG: vcs:MS6_A0927 O-acetylhomoserine (thiol)-lyase gene gene2436 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02437 VSVS12_02438 VSVS12_02438 VSVS12_02438 2670735 2672282 + Amino-acid carrier protein AlsT Belongs to the sodium:alanine (SAF) symporter family gene gene2437 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02438 VSVS12_02439 VSVS12_02439 VSVS12_02439 2672399 2672995 - Succinate-acetate/proton symporter SatP Uptake of acetate and succinate. Transport is energetically dependent on the protonmotive force (By similarity)%3B Belongs to the acetate uptake transporter (AceTr) (TC 2. A. 96) family gene gene2438 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02439 VSVS12_02440 VSVS12_02440 VSVS12_02440 2673285 2674805 - uncharacterized protein gene gene2439 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02440 VSVS12_02441 VSVS12_02441 guaA guaA 2674984 2676537 - GMP synthase (glutamine-hydrolyzing) Catalyzes the synthesis of GMP from XMP%3B Contains 1 glutamine amidotransferase type-1 domain%3B Contains 1 GMPS ATP-PPase (ATP pyrophosphatase) domain%3B KEGG: vch:VC0768 GMP synthase (glutamine-hydrolysing) gene gene2440 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02441 VSVS12_02442 VSVS12_02442 VSVS12_02442 2676650 2678113 - IMP dehydrogenase Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP)%2C the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides%2C and therefore plays an important role in the regulation of cell growth%3B Belongs to the IMPDH/GMPR family%3B Contains 2 CBS domains%3B KEGG: eco:b2508 IMP dehydrogenase gene gene2441 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02442 VSVS12_02443 VSVS12_02443 xseA xseA 2678347 2679678 + Exodeoxyribonuclease VII Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides%2C which are then degraded further into small acid-soluble oligonucleotides%3B Belongs to the XseA family%3B KEGG: vni:VIBNI_A2769 exodeoxyribonuclease VII large subunit gene gene2442 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02443 VSVS12_02444 VSVS12_02444 VSVS12_02444 2679819 2680049 - hypothetical protein gene gene2443 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02444 VSVS12_02445 VSVS12_02445 aarS aarS 2680354 2681259 - Alanine--tRNA ligase KEGG: vsp:VS_0624 alanyl-tRNA synthetase gene gene2444 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02445 VSVS12_02446 VSVS12_02446 VSVS12_02446 2681358 2682851 - GTPase Der GTPase that plays an essential role in the late steps of ribosome biogenesis%3B Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin- like GTPase superfamily. EngA (Der) GTPase family%3B Contains 2 EngA-type G (guanine nucleotide-binding) domains%3B Contains 1 KH-like domain gene gene2445 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02446 VSVS12_02447 VSVS12_02447 VSVS12_02447 2683038 2684198 - Outer membrane protein assembly factor BamB Part of the outer membrane protein assembly complex%2C which is involved in assembly and insertion of beta-barrel proteins into the outer membrane%3B Belongs to the BamB family gene gene2446 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02447 VSVS12_02448 VSVS12_02448 VSVS12_02448 2684210 2684824 - UPF0070 protein YfgM Belongs to the UPF0070 family gene gene2447 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02448 VSVS12_02449 VSVS12_02449 harS harS 2684929 2686197 - Histidine--tRNA ligase Belongs to the class-II aminoacyl-tRNA synthetase family%3B KEGG: hin:HI0369 histidyl-tRNA synthetase gene gene2448 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02449 VSVS12_02450 VSVS12_02450 gcpE gcpE 2686233 2687351 - (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase (ferredoxin) Converts 2C-methyl-D-erythritol 2%2C4-cyclodiphosphate (ME-2%2C4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate%3B Belongs to the IspG family%3B KEGG: vtu:IX91_03515 (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase gene gene2449 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02450 VSVS12_02451 VSVS12_02451 VSVS12_02451 2687360 2688316 - Cytoskeleton protein RodZ Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis%3B Belongs to the RodZ family%3B Contains 1 HTH cro/C1-type DNA-binding domain gene gene2450 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02451 VSVS12_02452 VSVS12_02452 rlmN rlmN 2688749 2689873 - 23S rRNA (adenine(2503)-C(2))-methyltransferase Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity%3B Belongs to the radical SAM superfamily. RlmN family%3B KEGG: vch:VC0757 23S rRNA (adenine2503-C2)-methyltransferase gene gene2451 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02452 VSVS12_02453 VSVS12_02453 VSVS12_02453 2690007 2690450 - Sulfur acceptor protein CsdE Stimulates the cysteine desulfurase activity of CsdA. Contains a cysteine residue (Cys-61) that acts to accept sulfur liberated via the desulfurase activity of CsdA. May be able to transfer sulfur to TcdA/CsdL. Seems to support the function of TcdA in the generation of cyclic threonylcarbamoyladenosine at position 37 (ct(6)A37) in tRNAs that read codons beginning with adenine. Does not appear to participate in Fe/S biogenesis (By similarity)%3B Belongs to the SufE family gene gene2452 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02453 VSVS12_02454 VSVS12_02454 sae2 sae2 2690461 2691270 - E1 ubiquitin-activating enzyme Catalyzes the ATP-dependent dehydration of threonylcarbamoyladenosine at position 37 (t(6)A37) to form cyclic t(6)A37 (ct(6)A37) in tRNAs that read codons beginning with adenine%3B Belongs to the HesA/MoeB/ThiF family%3B KEGG: cit:102625845 ubiquitin-like 1-activating enzyme E1 B gene gene2453 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02454 VSVS12_02455 VSVS12_02455 VSVS12_02455 2691374 2692474 - Membrane-bound lytic murein transglycosylase Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division. Degrades murein glycan strands and insoluble%2C high-molecular weight murein sacculi (By similarity) gene gene2454 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02455 VSVS12_02456 VSVS12_02456 VSVS12_02456 2692564 2692986 - hypothetical protein gene gene2455 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02456 VSVS12_02457 VSVS12_02457 VSVS12_02457 2693225 2694484 + Amino-acid N-acetyltransferase Belongs to the acetyltransferase family. ArgA subfamily%3B Contains 1 N-acetyltransferase domain%3B KEGG: vch:VC2316 amino-acid N-acetyltransferase gene gene2456 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02457 VSVS12_02458 VSVS12_02458 VSVS12_02458 2694730 2694918 + hypothetical protein gene gene2457 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02458 VSVS12_02459 VSVS12_02459 recD recD 2694964 2697078 - Exodeoxyribonuclease V A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a rapid (>1 kb/second) and highly processive (>30 kb) ATP-dependent bidirectional helicase. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator%2C 5'-GCTGGTGG-3') sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to Chi site%2C by nicking one strand or switching the strand degraded (depending on the reaction conditions). The properties and activities of the enzyme are changed at Chi. In the holoenzyme this subunit contributes ssDNA-dependent ATPase and fast 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD%3B Belongs to the RecD family%3B KEGG: van:VAA_03635 exodeoxyribonuclease V alpha subunit%3B overlaps another CDS with the same product name gene gene2458 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02459 VSVS12_02460 VSVS12_02460 recB recB 2697075 2700695 - Exodeoxyribonuclease V A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. In the holoenzyme this subunit contributes ATPase%2C 3'-5' helicase%2C exonuclease activity and loads RecA onto ssDNA%3B Belongs to the helicase family. UvrD subfamily%3B Contains 1 uvrD-like helicase ATP-binding domain%3B Contains 1 uvrD-like helicase C-terminal domain%3B KEGG: vcy:IX92_02700 exodeoxyribonuclease V beta subunit%3B overlaps another CDS with the same product name gene gene2459 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02460 VSVS12_02461 VSVS12_02461 recC recC 2701049 2704570 - Exodeoxyribonuclease V A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. In the holoenzyme this subunit recognizes the wild- type Chi sequence%2C and when added to isolated RecB increases its ATP-dependent helicase processivity%3B Belongs to the RecC family%3B KEGG: ype:YPO1018 exodeoxyribonuclease V gamma subunit gene gene2460 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02461 VSVS12_02462 VSVS12_02462 VSVS12_02462 2704757 2705731 - hypothetical protein gene gene2461 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02462 VSVS12_02463 VSVS12_02463 VSVS12_02463 2705888 2706787 + RuBisCO operon transcriptional regulator Trans-acting transcriptional regulator of RuBisCO genes (rbcAB) expression. Contains 1 HTH lysR-type DNA-binding domain gene gene2462 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02463 VSVS12_02464 VSVS12_02464 VSVS12_02464 2706958 2707266 + uncharacterized protein gene gene2463 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02464 VSVS12_02465 VSVS12_02465 VSVS12_02465 2707359 2710496 - putative transporter Could be a drug efflux pump%3B Belongs to the resistance-nodulation-cell division (RND) (TC 2. A. 6) family gene gene2464 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02465 VSVS12_02466 VSVS12_02466 VSVS12_02466 2710496 2711572 - Macrolide export protein Part of the tripartite efflux system MacAB-TolC. MacA stimulates the ATPase activity of MacB by promoting the closed ATP-bound state of MacB%2C increases the capacity of MacB to bind macrolides such as erythromycin%2C and provides a physical link between MacB and TolC. When overexpressed%2C the system confers resistance against macrolides composed of 14- and 15-membered lactones but no or weak resistance against 16-membered ones. In addition%2C MacA binds tightly rough-core lipopolysaccharide (R- LPS)%2C suggesting that the system could also transport R-LPS or a similar glycolipid%3B Belongs to the membrane fusion protein (MFP) (TC 8. A. 1) family gene gene2465 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02466 VSVS12_02467 VSVS12_02467 VSVS12_02467 2711845 2711929 + tRNA-Tyr tRNA gene2466 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02467 VSVS12_02468 VSVS12_02468 VSVS12_02468 2712034 2712118 + tRNA-Tyr tRNA gene2467 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02468 VSVS12_02469 VSVS12_02469 VSVS12_02469 2712215 2712299 + tRNA-Tyr tRNA gene2468 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02469 VSVS12_02470 VSVS12_02470 VSVS12_02470 2712397 2712481 + tRNA-Tyr tRNA gene2469 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02470 VSVS12_02471 VSVS12_02471 VSVS12_02471 2712687 2713433 + Copper homeostasis protein CutC Involved in copper homeostasis%3B Belongs to the CutC family gene gene2470 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02471 VSVS12_02472 VSVS12_02472 VSVS12_02472 2713729 2714427 - Phosphate-specific transport system accessory protein PhoU Part of the phosphate (Pho) regulon%2C which plays a key role in phosphate homeostasis. Encoded together with proteins of the phosphate-specific transport (Pst) system in the polycistronic pstSCAB-phoU operon. PhoU is essential for the repression of the Pho regulon at high phosphate conditions. In this role%2C it may bind%2C possibly as a chaperone%2C to PhoR%2C PhoB or a PhoR-PhoB complex to promote dephosphorylation of phospho-PhoB%2C or inhibit formation of the PhoR-PhoB transitory complex. Is also part of complex networks important for bacterial virulence%2C tolerance to antibiotics and stress response (By similarity)%3B Belongs to the PhoU family gene gene2471 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02472 VSVS12_02473 VSVS12_02473 VSVS12_02473 2714529 2715347 - Phosphate-transporting ATPase Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system%3B Belongs to the ABC transporter superfamily. Phosphate importer (TC 3. A. 1. 7) family%3B Contains 1 ABC transporter domain%3B KEGG: vsp:VS_0587 phosphate transport system ATP-binding protein gene gene2472 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02473 VSVS12_02474 VSVS12_02474 VSVS12_02474 2715350 2717008 - Phosphate transport system permease protein Part of the binding-protein-dependent transport system for phosphat%3B probably responsible for the translocation of the substrate across the membrane. Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily%3B Contains 1 ABC transmembrane type-1 domain gene gene2473 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02474 VSVS12_02475 VSVS12_02475 VSVS12_02475 2717035 2719221 - putative ABC transporter permease protein YqgH Part of the binding-protein-dependent transport system YqgGHIJK. Probably responsible for the translocation of the substrate across the membrane (By similarity)%3B Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily%3B Contains 1 ABC transmembrane type-1 domain gene gene2474 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02475 VSVS12_02476 VSVS12_02476 VSVS12_02476 2719534 2721039 + Exopolyphosphatase Degradation of inorganic polyphosphates. Orthophosphate is released progressively from the ends of polyphosphate. Belongs to the GppA/Ppx family%3B KEGG: rbu:PG1C_03670 exopolyphosphatase / guanosine-5'-triphosphate%2C3'-diphosphate pyrophosphatase gene gene2475 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02476 VSVS12_02477 VSVS12_02477 VSVS12_02477 2721114 2722112 - Phosphate-binding protein PstS Involved in the system for phosphate transport across the cytoplasmic membrane. The ability of PstS to bind phosphate may allow it to acquire phosphate from its host%3B Belongs to the PstS family gene gene2476 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02477 VSVS12_02478 VSVS12_02478 phoR phoR 2722112 2723407 - Histidine kinase Member of the two-component regulatory system PhoR/PhoB involved in the phosphate regulon genes expression. PhoR may function as a membrane-associated protein kinase that phosphorylates PhoB in response to environmental signals. Contains 1 histidine kinase domain%3B Contains 1 PAS (PER-ARNT-SIM) domain%3B KEGG: eco:b0400 two-component system%2C OmpR family%2C phosphate regulon sensor histidine kinase PhoR gene gene2477 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02478 VSVS12_02479 VSVS12_02479 VSVS12_02479 2723413 2724102 - Phosphate regulon transcriptional regulatory protein This protein is a positive regulator for the phosphate regulon. Transcription of this operon is positively regulated by PhoB and PhoR when phosphate is limited (By similarity)%3B Contains 1 OmpR/PhoB-type DNA-binding domain%3B Contains 1 response regulatory domain gene gene2478 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02479 VSVS12_02480 VSVS12_02480 VSVS12_02480 2724360 2725274 + Recombination-associated protein RdgC May be involved in recombination%3B Belongs to the RdgC family gene gene2479 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02480 VSVS12_02481 VSVS12_02481 VSVS12_02481 2725429 2726829 + putative protease Belongs to the peptidase U32 family%3B KEGG: vpa:VP0567 putative protease%3B Acting on peptide bonds (peptidases) gene gene2480 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02481 VSVS12_02482 VSVS12_02482 VSVS12_02482 2726850 2727104 + putative ferredoxin-like protein Contains 2 4Fe-4S ferredoxin-type domains gene gene2481 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02482 VSVS12_02483 VSVS12_02483 VSVS12_02483 2727195 2727503 - hypothetical protein gene gene2482 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02483 VSVS12_02484 VSVS12_02484 mepA mepA 2727738 2728613 - Penicillin-insensitive murein endopeptidase Involved in the removal of murein from the sacculus. May also facilitate integration of nascent murein strands into the sacculus by cleaving the peptide bonds between neighboring strands in mature murein%3B Belongs to the peptidase M74 family%3B KEGG: eco:b2328 penicillin-insensitive murein endopeptidase%3B Metalloendopeptidases gene gene2483 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02484 VSVS12_02485 VSVS12_02485 VSVS12_02485 2728653 2728985 - hypothetical protein gene gene2484 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02485 VSVS12_02486 VSVS12_02486 VSVS12_02486 2729132 2730079 - Protein translocase subunit SecF Expression of V. alginolyticus SecDF in an E. coli secDF mutant restores protein export in a Na(+)-dependent manner%2C strongly suggesting SecDF functions via cation-coupled protein translocation%3B Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)%3B Belongs to the SecD/SecF family. SecF subfamily gene gene2485 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02486 VSVS12_02487 VSVS12_02487 VSVS12_02487 2730094 2731950 - Protein translocase subunit Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA%3B Belongs to the SecD/SecF family. SecD subfamily gene gene2486 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02487 VSVS12_02488 VSVS12_02488 VSVS12_02488 2731971 2732300 - UPF0092 membrane protein Belongs to the UPF0092 family gene gene2487 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02488 VSVS12_02489 VSVS12_02489 VSVS12_02489 2732503 2733636 - tRNA-guanine(34) transglycosylase Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp%2C -Asn%2C -His and -Tyr). After this exchange%2C a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine%2C resulting in the hypermodified nucleoside queuosine (Q) (7-(((4%2C5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity)%3B Belongs to the queuine tRNA-ribosyltransferase family%3B KEGG: vch:VC0741 queuine tRNA-ribosyltransferase gene gene2488 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02489 VSVS12_02490 VSVS12_02490 queA queA 2733909 2734961 - S-adenosylmethionine:tRNA ribosyltransferase-isomerase Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)%3B Belongs to the QueA family%3B KEGG: hdu:HD1257 S-adenosylmethionine:tRNA ribosyltransferase-isomerase gene gene2489 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02490 VSVS12_02491 VSVS12_02491 VSVS12_02491 2735237 2737177 + Transducer protein BasT Mediates chemotaxis towards five attractant amino acids (leucine%2C isoleucine%2C valine%2C methionine and cysteine). Probably transduces the signal from the substrate-binding protein BasB to the histidine kinase CheA%3B Contains 2 HAMP domains%3B Contains 1 methyl-accepting transducer domain gene gene2490 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02491 VSVS12_02492 VSVS12_02492 VSVS12_02492 2737446 2737889 + uncharacterized protein Contains 2 CBS domains gene gene2491 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02492 VSVS12_02493 VSVS12_02493 aceA aceA 2738133 2739443 - Isocitrate lyase Involved in the persistence and virulence of Mycobacterium. Catalyzes the reversible formation of succinate and glyoxylate from isocitrate%2C a key step of the glyoxylate cycle%2C which operates as an anaplerotic route for replenishing the tricarboxylic acid cycle during growth on fatty acid substrates%3B Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family%3B KEGG: vch:VC0736 isocitrate lyase gene gene2492 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02493 VSVS12_02494 VSVS12_02494 aceB aceB 2739604 2741241 - Malate synthase Does not seem to be essential for lipid utilization and gluconeogenesis in seedlings%3B Belongs to the malate synthase family%3B KEGG: vfu:vfu_A02800 malate synthase gene gene2493 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02494 VSVS12_02495 VSVS12_02495 VSVS12_02495 2741838 2742743 - HTH-type transcriptional regulator EstR Transcriptional regulator of the esterase operon. Contains 1 HTH lysR-type DNA-binding domain gene gene2494 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02495 VSVS12_02496 VSVS12_02496 prdX prdX 2742943 2743551 + Peroxiredoxin Belongs to the AhpC/TSA family%3B Contains 1 thioredoxin domain%3B KEGG: vvu:VV1_0453 peroxiredoxin (alkyl hydroperoxide reductase subunit C) gene gene2495 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02496 VSVS12_02497 VSVS12_02497 VSVS12_02497 2744088 2744780 + hypothetical protein gene gene2496 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02497 VSVS12_02498 VSVS12_02498 VSVS12_02498 2744836 2745828 + hypothetical protein gene gene2497 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02498 VSVS12_02499 VSVS12_02499 dapD dapD 2746256 2747287 + 2%2C3%2C4%2C5-tetrahydropyridine-2%2C6-dicarboxylate N-succinyltransferase Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA%3B Belongs to the type 2 tetrahydrodipicolinate N- succinyltransferase family%3B KEGG: vvu:VV1_1790 2%2C3%2C4%2C5-tetrahydropyridine-2-carboxylate N-succinyltransferase gene gene2498 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02499 VSVS12_02500 VSVS12_02500 VSVS12_02500 2747435 2748556 + Membrane-bound lytic murein transglycosylase Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division%3B Belongs to the transglycosylase Slt family gene gene2499 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02500 VSVS12_02501 VSVS12_02501 VSVS12_02501 2748621 2749805 - hypothetical protein gene gene2500 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02501 VSVS12_02502 VSVS12_02502 VSVS12_02502 2750087 2750641 + hypothetical protein gene gene2501 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02502 VSVS12_02503 VSVS12_02503 VSVS12_02503 2750773 2752116 + putative transporter YisQ Belongs to the multi antimicrobial extrusion (MATE) (TC 2. A. 66. 1) family gene gene2502 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02503 VSVS12_02504 VSVS12_02504 VSVS12_02504 2752338 2753006 + hypothetical protein gene gene2503 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02504 VSVS12_02505 VSVS12_02505 VSVS12_02505 2753078 2754013 - HTH-type transcriptional regulator LeuO A global transcription factor. Activates transcription of the 9 following operon%3B yjjQ-bglJ%2C yjjP%2C acrEF%2C ybdO%2C yjcRQP%2C casABCDE12%2C rhsD-ybbC%2C fepE and gltF%2C in most cases it probably interferes with silencing by H-NS and activates transcription. Represses transcription of the 3 following operon%3B uxaCA%2C sdaCB and yjiY. H-NS repression of the bgl operon%2C leading to the ability to metabolize some beta-glucosides. It also directly activates the bgl operon. Activation is H-NS and BglJ-RcsB independent%3B Contains 1 HTH lysR-type DNA-binding domain gene gene2504 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02505 VSVS12_02506 VSVS12_02506 VSVS12_02506 2754119 2755264 + Putative uncharacterized transporter Belongs to the chromate ion transporter (CHR) (TC 2. A. 51) family gene gene2505 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02506 VSVS12_02507 VSVS12_02507 VSVS12_02507 2755349 2755987 - Peptidoglycan-associated lipoprotein Thought to play a role in bacterial envelope integrity. Very strongly associated with the peptidoglycan (By similarity)%3B Belongs to the OmpA family. Pal subfamily%3B Contains 1 OmpA-like domain gene gene2506 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02507 VSVS12_02508 VSVS12_02508 VSVS12_02508 2756033 2757304 - hypothetical protein gene gene2507 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02508 VSVS12_02509 VSVS12_02509 VSVS12_02509 2757308 2757859 - hypothetical protein gene gene2508 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02509 VSVS12_02510 VSVS12_02510 VSVS12_02510 2757834 2758319 - hypothetical protein gene gene2509 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02510 VSVS12_02511 VSVS12_02511 VSVS12_02511 2758329 2759126 - hypothetical protein gene gene2510 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02511 VSVS12_02512 VSVS12_02512 VSVS12_02512 2759137 2760039 - hypothetical protein gene gene2511 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02512 VSVS12_02513 VSVS12_02513 VSVS12_02513 2760039 2760959 - hypothetical protein gene gene2512 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02513 VSVS12_02514 VSVS12_02514 VSVS12_02514 2760956 2762239 - Type IV secretion system protein VirB11 The virB operon is essential for intracellular survival and is not involved in the invasion process. Constitutes a major determinant of virulence in mice. Virb11 is essential for pathogenesis in mice but is not required for intracellular survival%3B Belongs to the GSP E family gene gene2513 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02514 VSVS12_02515 VSVS12_02515 VSVS12_02515 2762243 2763478 - hypothetical protein gene gene2514 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02515 VSVS12_02516 VSVS12_02516 VSVS12_02516 2763490 2764008 - hypothetical protein gene gene2515 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02516 VSVS12_02517 VSVS12_02517 VSVS12_02517 2764005 2765324 - uncharacterized protein Involved in the secretion of an unknown compound%3B Belongs to the GSP D family%3B Contains 1 BON domain gene gene2516 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02517 VSVS12_02518 VSVS12_02518 VSVS12_02518 2765347 2766141 - hypothetical protein gene gene2517 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02518 VSVS12_02519 VSVS12_02519 VSVS12_02519 2766227 2767435 - hypothetical protein gene gene2518 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02519 VSVS12_02520 VSVS12_02520 cpaA cpaA 2767539 2767913 - Prepilin peptidase KEGG: mvs:MVIS_0924 prepilin peptidase CpaA gene gene2519 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02520 VSVS12_02521 VSVS12_02521 VSVS12_02521 2767929 2768129 - hypothetical protein gene gene2520 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02521 VSVS12_02522 VSVS12_02522 VSVS12_02522 2768443 2768853 + hypothetical protein gene gene2521 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02522 VSVS12_02523 VSVS12_02523 VSVS12_02523 2768893 2770101 + hypothetical protein gene gene2522 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02523 VSVS12_02524 VSVS12_02524 VSVS12_02524 2770655 2772340 + Long-chain-fatty-acid--CoA ligase Long chain fatty acid acyl-CoA synthetases catalyze the formation of a thiester bond between a free fatty acid and coenzyme A during fatty acid metabolic process. May mediate fatty acid retrieval from the lumen of endosomes into the cytoplasm%3B Belongs to the ATP-dependent AMP-binding enzyme family%3B KEGG: asd:AS9A_3933 long-chain acyl-CoA synthetase gene gene2523 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02524 VSVS12_02525 VSVS12_02525 VSVS12_02525 2772521 2773414 + HTH-type transcriptional activator AmpR Regulates the expression of the beta-lactamase gene. Represses cephalosporinase (AmpC) in the presence of beta-lactams and induces it in the absence of them. Contains 1 HTH lysR-type DNA-binding domain gene gene2524 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02525 VSVS12_02526 VSVS12_02526 VSVS12_02526 2773550 2775637 - Elongation factor G Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step%2C the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites%2C respectively. Catalyzes the coordinated movement of the two tRNA molecules%2C the mRNA and conformational changes in the ribosome%3B Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily%3B Contains 1 tr-type G (guanine nucleotide-binding) domain gene gene2525 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02526 VSVS12_02527 VSVS12_02527 VSVS12_02527 2776198 2777577 - DNA repair protein RadA May play a role in the repair of endogenous alkylation damage. Belongs to the RecA family. RadA subfamily gene gene2526 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02527 VSVS12_02528 VSVS12_02528 VSVS12_02528 2777711 2780053 + hypothetical protein gene gene2527 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02528 VSVS12_02529 VSVS12_02529 serB serB 2780274 2781113 - Phosphoserine phosphatase Catalyzes the dephosphorylation of phosphoserine (P- Ser)%3B Belongs to the SerB family%3B KEGG: vch:VC2345 phosphoserine phosphatase gene gene2528 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02529 VSVS12_02530 VSVS12_02530 VSVS12_02530 2781265 2781867 + Protein AhpA When anaerobically expressed in wild-type E. coli K12 confers a hemolytic phenotype%2C but not in an sheA mutant. Suggests it effects the expression of the latent E. coli K12 hemolysin sheA under anaerobic conditions%3B Belongs to the Smp family gene gene2529 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02530 VSVS12_02531 VSVS12_02531 VSVS12_02531 2782002 2782292 - Putative transposase InsK for insertion sequence element IS150 Involved in the transposition of the insertion sequence IS150. Belongs to the transposase IS3/IS150/IS904 family%3B Contains 1 integrase catalytic domain gene gene2530 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02531 VSVS12_02532 VSVS12_02532 VSVS12_02532 2782859 2783173 - hypothetical protein gene gene2531 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02532 VSVS12_02533 VSVS12_02533 deoD deoD 2783343 2784062 - Purine-nucleoside phosphorylase Belongs to the PNP/UDP phosphorylase family%3B KEGG: eco:b4384 purine-nucleoside phosphorylase gene gene2532 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02533 VSVS12_02534 VSVS12_02534 deoB deoB 2784126 2785346 - Phosphopentomutase Phosphotransfer between the C1 and C5 carbon atoms of pentose%3B Belongs to the phosphopentomutase family%3B KEGG: eco:b4383 phosphopentomutase gene gene2533 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02534 VSVS12_02535 VSVS12_02535 deoA deoA 2785404 2786732 - Thymidine phosphorylase The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources%2C or in the rescue of pyrimidine bases for nucleotide synthesis%3B Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family%3B KEGG: eta:ETA_06670 thymidine phosphorylase gene gene2534 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02535 VSVS12_02536 VSVS12_02536 deoC deoC 2786960 2787736 - Deoxyribose-phosphate aldolase Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate%3B Belongs to the DeoC/FbaB aldolase family. DeoC type 2 subfamily%3B KEGG: kln:LH22_05675 deoxyribose-phosphate aldolase gene gene2535 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02536 VSVS12_02537 VSVS12_02537 VSVS12_02537 2788262 2789566 - Pyrimidine nucleoside transport protein Belongs to the concentrative nucleoside transporter (CNT) (TC 2. A. 41) family gene gene2536 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02537 VSVS12_02538 VSVS12_02538 VSVS12_02538 2789771 2790544 - D-aminoacyl-tRNA deacylase Catalyzes the hydrolysis of D-tyrosyl-tRNA(Tyr)%3B Belongs to the TatD-type hydrolase family. DTD3 subfamily%3B KEGG: vvu:VV1_1722 TatD DNase family protein%3B Endodeoxyribonucleases producing 5'-phosphomonoesters gene gene2537 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02538 VSVS12_02539 VSVS12_02539 VSVS12_02539 2790544 2790696 - hypothetical protein gene gene2538 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02539 VSVS12_02540 VSVS12_02540 VSVS12_02540 2790709 2791482 - UPF0246 protein Belongs to the UPF0246 family gene gene2539 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02540 VSVS12_02541 VSVS12_02541 VSVS12_02541 2791590 2793023 - putative transporter Belongs to the sodium:alanine (SAF) symporter family gene gene2540 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02541 VSVS12_02542 VSVS12_02542 VSVS12_02542 2793715 2793897 + hypothetical protein gene gene2541 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02542 VSVS12_02543 VSVS12_02543 VSVS12_02543 2793952 2794503 - hypothetical protein gene gene2542 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02543 VSVS12_02544 VSVS12_02544 VSVS12_02544 2794682 2795365 - Uracil-DNA glycosylase Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine%3B Belongs to the uracil-DNA glycosylase family%3B KEGG: panp:PSNIH2_02975 uracil-DNA glycosylase gene gene2543 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02544 VSVS12_02545 VSVS12_02545 VSVS12_02545 2795453 2796319 - Deoxyribonuclease IV Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin%3B Belongs to the AP endonuclease 2 family%3B KEGG: ypk:y2879 deoxyribonuclease IV gene gene2544 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02545 VSVS12_02546 VSVS12_02546 VSVS12_02546 2796656 2797033 + Autonomous glycyl radical cofactor Acts as a radical domain for damaged PFL and possibly other radical proteins%3B Contains 1 glycine radical domain gene gene2545 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02546 VSVS12_02547 VSVS12_02547 VSVS12_02547 2797506 2798966 + GlcNAc-binding protein Probably interacts with GlcNAc residues. May promote attachment to both epithelial cell surfaces and chitin%3B Belongs to the GbpA family%3B Contains 1 chitin-binding type-3 domain%3B Contains 1 chitin-binding type-4 domain gene gene2546 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02547 VSVS12_02548 VSVS12_02548 VSVS12_02548 2799111 2799977 + putative HTH-type transcriptional regulator Contains 1 HTH lysR-type DNA-binding domain gene gene2547 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02548 VSVS12_02549 VSVS12_02549 VSVS12_02549 2799907 2800581 - UPF0721 transmembrane protein Belongs to the UPF0721 family gene gene2548 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02549 VSVS12_02550 VSVS12_02550 carB carB 2800880 2804110 - Carbamoyl-phosphate synthase (glutamine-hydrolyzing) Belongs to the CarB family%3B Contains 2 ATP-grasp domains%3B KEGG: hde:HDEF_0108 carbamoyl-phosphate synthase large subunit gene gene2549 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02550 VSVS12_02551 VSVS12_02551 carA carA 2804127 2805266 - Carbamoyl-phosphate synthase (glutamine-hydrolyzing) Belongs to the CarA family%3B Contains 1 glutamine amidotransferase type-1 domain%3B KEGG: bcc:BCc_091 carbamoyl-phosphate synthase small subunit gene gene2550 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02551 VSVS12_02552 VSVS12_02552 dapB dapB 2805782 2806591 - 4-hydroxy-tetrahydrodipicolinate reductase Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate%3B Belongs to the DapB family%3B KEGG: spe:Spro_0712 4-hydroxy-tetrahydrodipicolinate reductase gene gene2551 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02552 VSVS12_02553 VSVS12_02553 mutT mutT 2806708 2807106 - 8-oxo-dGTP diphosphatase Involved in the GO system responsible for removing an oxidatively damaged form of guanine (7%2C8-dihydro-8-oxoguanine) from DNA and the nucleotide pool. 8-oxo-dGTP is inserted opposite dA and dC residues of template DNA with almost equal efficiency thus leading to A. T to G. C transversions. MutT specifically degrades 8-oxo-dGTP to the monophosphate. Belongs to the Nudix hydrolase family%3B Contains 1 nudix hydrolase domain%3B KEGG: vch:VC2392 8-oxo-dGTP diphosphatase gene gene2552 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02553 VSVS12_02554 VSVS12_02554 VSVS12_02554 2807416 2810145 - Protein translocase subunit SecA Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane%2C serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane%3B Belongs to the SecA family gene gene2553 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02554 VSVS12_02555 VSVS12_02555 VSVS12_02555 2810466 2810930 + hypothetical protein gene gene2554 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02555 VSVS12_02556 VSVS12_02556 lpxC lpxC 2810995 2811912 - UDP-3-O-acyl-N-acetylglucosamine deacetylase Involved in the biosynthesis of lipid A%2C a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell%3B Belongs to the LpxC family%3B KEGG: eco:b0096 UDP-3-O-(3-hydroxymyristoyl) N-acetylglucosamine deacetylase gene gene2555 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02556 VSVS12_02557 VSVS12_02557 VSVS12_02557 2812010 2813233 - Cell division protein FtsZ Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity%3B Belongs to the FtsZ family gene gene2556 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02557 VSVS12_02558 VSVS12_02558 VSVS12_02558 2813264 2814526 - Cell division protein FtsA Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring%3B Belongs to the FtsA/MreB family gene gene2557 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02558 VSVS12_02559 VSVS12_02559 VSVS12_02559 2814519 2815301 - Cell division protein FtsQ Essential cell division protein. May link together the upstream cell division proteins%2C which are predominantly cytoplasmic%2C with the downstream cell division proteins%2C which are predominantly periplasmic. May control correct divisome assembly%3B Belongs to the FtsQ/DivIB family. FtsQ subfamily%3B Contains 1 POTRA domain gene gene2558 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02559 VSVS12_02560 VSVS12_02560 murC murC 2815472 2816932 - UDP-N-acetylmuramate--L-alanine ligase Cell wall formation%3B Belongs to the MurCDEF family%3B KEGG: vch:VC2400 UDP-N-acetylmuramate--alanine ligase gene gene2559 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02560 VSVS12_02561 VSVS12_02561 murG murG 2816944 2818005 - Undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)%3B Belongs to the glycosyltransferase 28 family. MurG subfamily%3B KEGG: vch:VC2401 UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase gene gene2560 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02561 VSVS12_02562 VSVS12_02562 VSVS12_02562 2817998 2819188 - Putative lipid II flippase FtsW Essential cell division protein. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane%3B Belongs to the SEDS family. FtsW subfamily gene gene2561 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02562 VSVS12_02563 VSVS12_02563 murD murD 2819237 2820559 - UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)%3B Belongs to the MurCDEF family%3B KEGG: vtu:IX91_12360 UDP-N-acetylmuramoylalanine--D-glutamate ligase gene gene2562 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02563 VSVS12_02564 VSVS12_02564 mraY mraY 2820572 2821654 - Phospho-N-acetylmuramoyl-pentapeptide-transferase First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan%3B Belongs to the glycosyltransferase 4 family. MraY subfamily%3B KEGG: psi:S70_03880 phospho-N-acetylmuramoyl-pentapeptide-transferase gene gene2563 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02564 VSVS12_02565 VSVS12_02565 murF murF 2821651 2823009 - UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide%2C the precursor of murein%3B Belongs to the MurCDEF family. MurF subfamily%3B KEGG: epy:EpC_07390 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase gene gene2564 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02565 VSVS12_02566 VSVS12_02566 murE murE 2823006 2824502 - UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2%2C6-diaminopimelate ligase Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan%3B Belongs to the MurCDEF family. MurE subfamily%3B KEGG: bva:BVAF_138 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2%2C6-diaminopimelate ligase gene gene2565 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02566 VSVS12_02567 VSVS12_02567 VSVS12_02567 2824517 2826244 - Peptidoglycan synthase FtsI Essential cell division protein that is required for the synthesis of peptidoglycan at the division septum. Catalyzes the synthesis of cross-linked peptidoglycan from the lipid-linked precursors%3B Belongs to the transpeptidase family gene gene2566 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02567 VSVS12_02568 VSVS12_02568 VSVS12_02568 2826241 2826558 - Cell division protein FtsL Essential cell division protein. May link together the upstream cell division proteins%2C which are predominantly cytoplasmic%2C with the downstream cell division proteins%2C which are predominantly periplasmic%3B Belongs to the FtsL family gene gene2567 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02568 VSVS12_02569 VSVS12_02569 mraW mraW 2826566 2827516 - 16S rRNA (cytosine(1402)-N(4))-methyltransferase Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA%3B Belongs to the methyltransferase superfamily. RsmH family%3B KEGG: vsp:VS_0442 16S rRNA (cytosine1402-N4)-methyltransferase gene gene2568 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02569 VSVS12_02570 VSVS12_02570 rsmI rsmI 2828653 2829516 - 16S rRNA (cytidine(1402)-2'-O)-methyltransferase Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA%3B Belongs to the methyltransferase superfamily. RsmI family%3B KEGG: vch:VC0582 16S rRNA (cytidine1402-2'-O)-methyltransferase gene gene2569 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02570 VSVS12_02571 VSVS12_02571 VSVS12_02571 2829580 2831460 + Penicillin-binding protein activator LpoA Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a)%3B Belongs to the LpoA family gene gene2570 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02571 VSVS12_02572 VSVS12_02572 VSVS12_02572 2831441 2831803 + UPF0102 protein Belongs to the UPF0102 family gene gene2571 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02572 VSVS12_02573 VSVS12_02573 VSVS12_02573 2831807 2832397 + Phosphoheptose isomerase Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate%3B Belongs to the SIS family. GmhA subfamily%3B Contains 1 SIS domain gene gene2572 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02573 VSVS12_02574 VSVS12_02574 VSVS12_02574 2832402 2832971 + uncharacterized protein Contains 2 BON domains gene gene2573 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02574 VSVS12_02575 VSVS12_02575 VSVS12_02575 2832968 2833120 - hypothetical protein gene gene2574 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02575 VSVS12_02576 VSVS12_02576 VSVS12_02576 2833068 2833544 - Stringent starvation protein Seems to act in concert with SspA in the regulation of several proteins during exponential and stationary-phase growth. The exact function of SspB is not yet known (By similarity)%3B Belongs to the SspB family gene gene2575 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02576 VSVS12_02577 VSVS12_02577 VSVS12_02577 2833570 2834205 - Stringent starvation protein Forms an equimolar complex with the RNA polymerase holoenzyme (RNAP) but not with the core enzyme%3B Belongs to the GST superfamily. HSP26 family%3B Contains 1 GST C-terminal domain%3B Contains 1 GST N-terminal domain gene gene2576 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02577 VSVS12_02578 VSVS12_02578 VSVS12_02578 2834306 2835043 - Cytochrome c1 gene gene2577 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02578 VSVS12_02579 VSVS12_02579 VSVS12_02579 2835040 2836305 - Cytochrome b/c1 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex)%2C which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis. c1 functions as an electron donor to cytochrome c. Belongs to the cytochrome b family%3B Contains 1 cytochrome c domain gene gene2578 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02579 VSVS12_02580 VSVS12_02580 rip1 rip1 2836305 2836898 - Quinol--cytochrome-c reductase Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex)%2C which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis. Contains 1 Rieske domain%3B KEGG: vch:VC0573 ubiquinol-cytochrome c reductase iron-sulfur subunit gene gene2579 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02580 VSVS12_02581 VSVS12_02581 VSVS12_02581 2837232 2837624 - 30S ribosomal protein S9 Belongs to the ribosomal protein S9P family gene gene2580 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02581 VSVS12_02582 VSVS12_02582 VSVS12_02582 2837639 2838067 - 50S ribosomal protein L13 This protein is one of the early assembly proteins of the 50S ribosomal subunit%2C although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly%3B Belongs to the ribosomal protein L13P family gene gene2581 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02582 VSVS12_02583 VSVS12_02583 VSVS12_02583 2838114 2838245 + hypothetical protein gene gene2582 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02583 VSVS12_02584 VSVS12_02584 VSVS12_02584 2838309 2839412 - Lactation elevated protein Belongs to the AFG1 ATPase family gene gene2583 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02584 VSVS12_02585 VSVS12_02585 VSVS12_02585 2839601 2840053 + Putative cytochrome d ubiquinol oxidase subunit To H. influenzae HI_1628 gene gene2584 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02585 VSVS12_02586 VSVS12_02586 degP degP 2840201 2841568 + Peptidase Do DegQ could degrade transiently denatured and unfolded proteins which accumulate in the periplasm following stress conditions. DegQ is efficient with Val-Xaa and Ile-Xaa peptide bonds%2C suggesting a preference for a beta-branched side chain amino acids. Only unfolded proteins devoid of disulfide bonds appear capable to be cleaved%2C thereby preventing non-specific proteolysis of folded proteins. DegQ can substitute for the periplasmic protease DegP%3B Belongs to the peptidase S1C family%3B Contains 2 PDZ (DHR) domains%3B KEGG: vpa:VP0433 serine protease Do gene gene2585 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02586 VSVS12_02587 VSVS12_02587 hhoB hhoB 2841687 2842751 + Serine endoprotease A site-1 protease (S1P) that cleaves the peptide bond between 'Val-148' and 'Ser-149' in RseA. Part of a regulated intramembrane proteolysis (RIP) cascade. When heat shock or other environmental stresses disrupt protein folding in the periplasm%2C DegS senses the accumulation of unassembled outer membrane porins (OMP) and then initiates RseA (anti sigma-E factor) degradation by cleaving its periplasmic domain%2C making it a substrate for subsequent cleavage by RseP. This cascade ultimately leads to the sigma-E-driven expression of a variety of factors dealing with folding stress in the periplasm and OMP assembly. Required for basal and stress-induced degradation of RseA (By similarity)%3B Belongs to the peptidase S1C family%3B Contains 1 PDZ (DHR) domain%3B KEGG: vvu:VV1_0604 serine protease DegS%3B Serine endopeptidases gene gene2586 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02587 VSVS12_02588 VSVS12_02588 parC parC 2842834 2845119 - DNA topoisomerase 4 subunit Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule%3B Belongs to the topoisomerase GyrA/ParC subunit family. ParC type 1 subfamily%3B KEGG: hpaz:K756_04620 topoisomerase IV subunit A%3B Other isomerases gene gene2587 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02588 VSVS12_02589 VSVS12_02589 parE parE 2845123 2847003 - DNA topoisomerase 4 subunit Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule. MukB stimulates the relaxation activity of topoisomerase IV and also has a modest effect on decatenation%3B Belongs to the type II topoisomerase family. ParE type 1 subfamily%3B Contains 1 Toprim domain%3B KEGG: vch:VC2431 topoisomerase IV subunit B%3B Other isomerases gene gene2588 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02589 VSVS12_02590 VSVS12_02590 VSVS12_02590 2847263 2847844 - Esterase Displays esterase activity toward palmitoyl-CoA and pNP- butyrate gene gene2589 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02590 VSVS12_02591 VSVS12_02591 VSVS12_02591 2847883 2848704 - 3'%2C5'-cyclic adenosine monophosphate phosphodiesterase CpdA Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP%2C thereby influencing cAMP-dependent processes (Probable)%3B Belongs to the cAMP phosphodiesterase class-III family gene gene2590 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02591 VSVS12_02592 VSVS12_02592 VSVS12_02592 2848714 2849190 - uncharacterized protein gene gene2591 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02592 VSVS12_02593 VSVS12_02593 nudF nudF 2849139 2849771 - ADP-ribose diphosphatase Acts on ADP-mannose and ADP-glucose as well as ADP- ribose. Prevents glycogen biosynthesis. The reaction catalyzed by this enzyme is a limiting step of the gluconeogenic process (By similarity)%3B Belongs to the Nudix hydrolase family. NudF subfamily%3B Contains 1 nudix hydrolase domain%3B KEGG: gni:GNIT_2884 ADP-ribose pyrophosphatase gene gene2592 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02593 VSVS12_02594 VSVS12_02594 VSVS12_02594 2850002 2851318 + Outer membrane protein TolC Outer membrane channel%2C which is required for the function of several efflux systems such as AcrAB-TolC%2C AcrEF-TolC%2C EmrAB-TolC and MacAB-TolC. These systems are involved in export of antibiotics and other toxic compounds from the cell. TolC is also involved in import of colicin E1 into the cells%3B Belongs to the outer membrane factor (OMF) (TC 1. B. 17) family gene gene2593 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02594 VSVS12_02595 VSVS12_02595 VSVS12_02595 2851448 2852722 - Transposase InsG for insertion sequence element IS4 Involved in the transposition of the insertion sequence IS4. Belongs to the transposase 11 family gene gene2594 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02595 VSVS12_02596 VSVS12_02596 VSVS12_02596 2852870 2854204 - Nitrogen assimilation regulatory protein NtrC Member of the two-component regulatory system NtrB/NtrC involved in the activation of nitrogen assimilatory genes such as GlnA. NtrC is phosphorylated by NtrB and interacts with sigma-54. Contains 1 response regulatory domain%3B Contains 1 sigma-54 factor interaction domain gene gene2595 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02596 VSVS12_02597 VSVS12_02597 karS karS 2854531 2856066 - Lysine--tRNA ligase Belongs to the class-II aminoacyl-tRNA synthetase family%3B KEGG: vvu:VV1_0526 lysyl-tRNA synthetase%2C class II gene gene2596 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02597 VSVS12_02598 VSVS12_02598 VSVS12_02598 2856100 2857032 - Peptide chain release factor Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA%3B Belongs to the prokaryotic/mitochondrial release factor family gene gene2597 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02598 VSVS12_02599 VSVS12_02599 VSVS12_02599 2857360 2858673 - Branched-chain amino acid transport system 2 carrier protein Component of the LIV-II transport system for branched- chain amino acids. BraB is specific for isoleucine%2C leucine and valine. The LIV-II transport system is coupled to sodium and lithium ions. Belongs to the branched chain amino acid transporter family gene gene2598 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02599 VSVS12_02600 VSVS12_02600 yfiC yfiC 2858983 2859702 + tRNA(1)(Val) (adenine(37)-N(6))-methyltransferase Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)%3B Belongs to the methyltransferase superfamily. tRNA (adenine-N(6)-)-methyltransferase family%3B KEGG: vpa:VP0506 tRNA1Val (adenine37-N6)-methyltransferase gene gene2599 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02600 VSVS12_02601 VSVS12_02601 VSVS12_02601 2859848 2861086 + RNA helicase Probable ATP-binding RNA helicase. Belongs to the DEAD box helicase family. DDX4/VASA subfamily%3B Contains 4 CCHC-type zinc fingers%3B Contains 1 helicase ATP-binding domain%3B Contains 1 helicase C-terminal domain%3B KEGG: vcy:IX92_12590 ATP-dependent RNA helicase SrmB gene gene2600 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02601 VSVS12_02602 VSVS12_02602 VSVS12_02602 2861348 2862937 - Peptide chain release factor Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP%2C but not by GMP%3B Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily%3B Contains 1 tr-type G (guanine nucleotide-binding) domain gene gene2601 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02602 VSVS12_02603 VSVS12_02603 rimI rimI 2863113 2863562 - Ribosomal-protein-alanine N-acetyltransferase This enzyme acetylates the N-terminal alanine of ribosomal protein S18%3B Belongs to the acetyltransferase family. RimI subfamily%3B Contains 1 N-acetyltransferase domain%3B KEGG: vfu:vfu_A00954 ribosomal-protein-alanine N-acetyltransferase gene gene2602 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02603 VSVS12_02604 VSVS12_02604 holD holD 2863571 2863966 - DNA-directed DNA polymerase KEGG: vtu:IX91_02585 DNA polymerase III subunit psi gene gene2603 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02604 VSVS12_02605 VSVS12_02605 yhbS yhbS 2864064 2864567 - putative N-acetyltransferase Belongs to the acetyltransferase family%3B Contains 1 N-acetyltransferase domain%3B KEGG: vch:VC0655 putative acetyltransferase%3B Transferring groups other than amino-acyl groups gene gene2604 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02605 VSVS12_02606 VSVS12_02606 VSVS12_02606 2864551 2865078 - uncharacterized protein gene gene2605 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02606 VSVS12_02607 VSVS12_02607 VSVS12_02607 2865269 2867311 + Diguanylate cyclase VdcA Diguanylate cyclase (DGC) that catalyzes the synthesis of cyclic diguanylate (c-di-GMP) via the condensation of 2 GTP molecules. Is involved in the modulation of intracellular c-di-GMP levels. Cyclic-di-GMP is a second messenger which positively regulates biofilm formation and negatively regulates virulence in V. cholerae%2C and is proposed to play an important role in the transition from persistence in the environment to survival in the host. Overexpression of vdcA results in increased biofilm formation%2C and reduced motility and virulence%3B Contains 1 GGDEF domain gene gene2606 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02607 VSVS12_02608 VSVS12_02608 VSVS12_02608 2867456 2868469 + putative protease YhbU Belongs to the peptidase U32 family%3B KEGG: eco:b3158 putative protease%3B Acting on peptide bonds (peptidases) gene gene2607 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02608 VSVS12_02609 VSVS12_02609 VSVS12_02609 2868488 2869363 + uncharacterized protein gene gene2608 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02609 VSVS12_02610 VSVS12_02610 VSVS12_02610 2869582 2871141 + 5'-nucleotidase Involved in the biosynthesis of the compatible solute mannosylglucosylglycerate through a phosphorylating pathway. Catalyzes the dephosphorylation of mannosylglucosyl-3- phosphoglycerate (MGPG) to mannosylglucosylglycerate (MGG). Can also dephosphorylate UDP-glucose%2C ADP-glucose%2C GDP-mannose%2C glucosyl-3-phosphoglycerate (GPG)%2C mannosyl-3-phosphoglycerate (MPG)%2C ADP%2C GDP and UDP%3B Belongs to the 5'-nucleotidase family%3B KEGG: wvi:Weevi_2014 5'-nucleotidase gene gene2609 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02610 VSVS12_02611 VSVS12_02611 VSVS12_02611 2871168 2872649 + hypothetical protein gene gene2610 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02611 VSVS12_02612 VSVS12_02612 VSVS12_02612 2872676 2874052 - putative multidrug resistance protein YoeA Belongs to the multi antimicrobial extrusion (MATE) (TC 2. A. 66. 1) family gene gene2611 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02612 VSVS12_02613 VSVS12_02613 VSVS12_02613 2874085 2874498 - Transcriptional regulator SlyA Transcription regulator that can specifically activate or repress expression of target genes%3B Belongs to the SlyA family%3B Contains 1 HTH marR-type DNA-binding domain gene gene2612 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02613 VSVS12_02614 VSVS12_02614 VSVS12_02614 2874620 2875528 - Lipoprotein NlpI May be involved in cell division. May play a role in bacterial septation or regulation of cell wall degradation during cell division (By similarity)%3B Contains 3 TPR repeats gene gene2613 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02614 VSVS12_02615 VSVS12_02615 VSVS12_02615 2875746 2877881 - Polyribonucleotide nucleotidyltransferase Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction%3B Belongs to the polyribonucleotide nucleotidyltransferase family%3B Contains 1 KH domain%3B Contains 1 S1 motif domain%3B KEGG: vch:VC0647 polyribonucleotide nucleotidyltransferase gene gene2614 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02615 VSVS12_02616 VSVS12_02616 VSVS12_02616 2878185 2878454 - 30S ribosomal protein S15 One of the primary rRNA binding proteins%2C it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA%3B Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome%3B Belongs to the ribosomal protein S15P family gene gene2615 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02616 VSVS12_02617 VSVS12_02617 VSVS12_02617 2878691 2879389 + Adenosylhomocysteine nucleosidase Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose%2C 5'-methylthioribose and S-ribosylhomocysteine%2C respectively%3B Belongs to the PNP/UDP phosphorylase family. MtnN subfamily%3B KEGG: eco:b0159 adenosylhomocysteine nucleosidase gene gene2616 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02617 VSVS12_02618 VSVS12_02618 cbiB cbiB 2879402 2880355 + Adenosylcobinamide-phosphate synthase Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group%3B Belongs to the CobD/CbiB family%3B KEGG: vvu:VV1_0559 adenosylcobinamide-phosphate synthase gene gene2617 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02618 VSVS12_02619 VSVS12_02619 VSVS12_02619 2880355 2881173 + Vitamin B12-binding protein Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC%3B Belongs to the BtuF family%3B Contains 1 Fe/B12 periplasmic-binding domain gene gene2618 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02619 VSVS12_02620 VSVS12_02620 VSVS12_02620 2881295 2881915 + UPF0126 membrane protein Belongs to the UPF0126 family gene gene2619 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02620 VSVS12_02621 VSVS12_02621 thrC thrC 2882019 2883302 - Threonine synthase Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine%3B Belongs to the threonine synthase family%3B KEGG: eco:b0004 threonine synthase gene gene2620 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02621 VSVS12_02622 VSVS12_02622 VSVS12_02622 2883299 2884267 - Homoserine kinase Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate%3B Belongs to the GHMP kinase family. Homoserine kinase subfamily%3B KEGG: vex:VEA_004456 homoserine kinase gene gene2621 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02622 VSVS12_02623 VSVS12_02623 thrA thrA 2884270 2886729 - Aspartate kinase In the N-terminal sectio%3B belongs to the aspartokinase family%3B In the C-terminal sectio%3B belongs to the homoserine dehydrogenase family%3B Contains 2 ACT domains%3B KEGG: eco:b0002 bifunctional aspartokinase / homoserine dehydrogenase 1 gene gene2622 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02623 VSVS12_02624 VSVS12_02624 VSVS12_02624 2887152 2887604 + hypothetical protein gene gene2623 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02624 VSVS12_02625 VSVS12_02625 VSVS12_02625 2887622 2888107 - Putative 4-hydroxy-4-methyl-2-oxoglutarate aldolase Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions (By similarity)%3B Belongs to the class II aldolase/RraA-like family gene gene2624 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02625 VSVS12_02626 VSVS12_02626 VSVS12_02626 2888138 2888521 - hypothetical protein gene gene2625 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02626 VSVS12_02627 VSVS12_02627 VSVS12_02627 2888853 2889569 + Transcriptional regulatory protein SrrA Member of the two-component regulatory system SrrA/SrrB%2C which is involved in the global regulation of staphylococcal virulence factors in response to environmental oxygen levels. SrrA binds to the agr%2C spa and tst promoters and represses their transcription%2C particularly under low-oxygen conditions. Activates its own expression (By similarity)%3B Contains 1 OmpR/PhoB-type DNA-binding domain%3B Contains 1 response regulatory domain gene gene2626 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02627 VSVS12_02628 VSVS12_02628 gmhC gmhC 2889726 2891156 - D-glycero-beta-D-manno-heptose-7-phosphate kinase Catalyzes the phosphorylation of D-glycero-D-manno- heptose 7-phosphate at the C-1 position to selectively form D- glycero-beta-D-manno-heptose-1%2C7-bisphosphate%3B Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate%2C yielding ADP-D-glycero-beta-D-manno- heptose%3B In the N-terminal sectio%3B belongs to the carbohydrate kinase PfkB family%3B In the C-terminal sectio%3B belongs to the cytidylyltransferase family%3B KEGG: vcf:IR04_17270 D-beta-D-heptose 7-phosphate kinase / D-beta-D-heptose 1-phosphate adenosyltransferase gene gene2627 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02628 VSVS12_02629 VSVS12_02629 glnE glnE 2891309 2894149 - [Glutamate--ammonia-ligase] adenylyltransferase Adenylation and deadenylation of glutamate--ammonia ligase%3B Belongs to the GlnE family%3B KEGG: vch:VC2438 glutamate-ammonia-ligase adenylyltransferase gene gene2628 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02629 VSVS12_02630 VSVS12_02630 VSVS12_02630 2894289 2895545 - Methyl-accepting chemotaxis serine transducer Receptor for the attractant L-serine and related amino acids. Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment%2C transduce a signal from the outside to the inside of the cell%2C and facilitate sensory adaptation through the variation of the level of methylation. Attractants increase the level of methylation while repellents decrease the level of methylation%2C the methyl groups are added by the methyltransferase CheR and removed by the methylesterase CheB. Contains 1 HAMP domain%3B Contains 1 methyl-accepting transducer domain gene gene2629 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02630 VSVS12_02631 VSVS12_02631 VSVS12_02631 2895649 2896449 + Potassium voltage-gated channel subfamily V member Potassium channel subunit that does not form functional channels by itself. Modulates KCNB1 and KCNB2 channel activity by shifting the threshold for inactivation to more negative values and by slowing the rate of inactivation. Can down-regulate the channel activity of KCNB1%2C KCNB2%2C KCNC4 and KCND1%2C possibly by trapping them in intracellular membranes (By similarity)%3B Belongs to the potassium channel family. V (TC 1. A. 1. 2) subfamily. Kv8. 1/KCNV1 sub-subfamily gene gene2630 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02631 VSVS12_02632 VSVS12_02632 ygiF ygiF 2896482 2897999 - Triphosphatase Involved in the hydrolysis of the beta-gamma- phosphoanhydride linkage of triphosphate-containing substrates (inorganic or nucleoside-linked). Catalyzes the hydrolysis of inorganic triphosphate (PPPi)%2C which could be cytotoxic because of its high affinity for calcium ion%2C thereby interfering with calcium signaling. It also hydrolyzes slowly thiamine triphosphate (ThTP). YgiF is a specific PPPase%2C but it contributes only marginally to the total PPPase activity in E. coli%2C where the main enzyme responsible for hydrolysis of PPPi is inorganic pyrophosphatase (PPase)%3B Contains 1 CHAD domain%3B Contains 1 CYTH domain%3B KEGG: pant:PSNIH1_03020 triphosphatase gene gene2631 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02632 VSVS12_02633 VSVS12_02633 VSVS12_02633 2898206 2898886 + UPF0111 protein Belongs to the UPF0111 family gene gene2632 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02633 VSVS12_02634 VSVS12_02634 VSVS12_02634 2899018 2900277 + Putative phosphate permease Potential transporter for phosphate. Belongs to the inorganic phosphate transporter (PiT) (TC 2. A. 20) family gene gene2633 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02634 VSVS12_02635 VSVS12_02635 VSVS12_02635 2900444 2901055 + uncharacterized protein To H. influenzae HI_1605 gene gene2634 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02635 VSVS12_02636 VSVS12_02636 VSVS12_02636 2901141 2901944 - General secretion pathway protein Involved in a general secretion pathway (GSP) for the export of proteins. Belongs to the ExeB/OutB/PulB family gene gene2635 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02636 VSVS12_02637 VSVS12_02637 VSVS12_02637 2901944 2903569 - General secretion pathway protein A Involved in a general secretion pathway (GSP) for the export of proteins. Belongs to the ExeA family gene gene2636 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02637 VSVS12_02638 VSVS12_02638 VSVS12_02638 2903659 2904870 + Multifunctional CCA protein Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C%2C C%2C and A to the tRNA nucleotide-73%2C using CTP and ATP as substrates and producing inorganic pyrophosphate. Also shows phosphatase%2C 2'- nucleotidase and 2'%2C3'-cyclic phosphodiesterase activities. These phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases%3B Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Bacterial CCA-adding enzyme type 1 subfamily%3B KEGG: wbr:WGLp238 tRNA nucleotidyltransferase (CCA-adding enzyme)%3B CCA tRNA nucleotidyltransferase gene gene2637 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02638 VSVS12_02639 VSVS12_02639 VSVS12_02639 2905835 2907136 - Phosphopyruvate hydratase Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis%3B Belongs to the enolase family%3B KEGG: eco:b2779 enolase gene gene2638 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02639 VSVS12_02640 VSVS12_02640 pyrG pyrG 2907213 2908853 - CTP synthase (glutamine hydrolyzing) Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen%3B Belongs to the CTP synthase family%3B Contains 1 glutamine amidotransferase type-1 domain%3B KEGG: eco:b2780 CTP synthase gene gene2639 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02640 VSVS12_02641 VSVS12_02641 mazG mazG 2909059 2909856 - ATP diphosphatase Involved in the regulation of bacterial cell survival under conditions of nutritional stress. Regulates the MazE-MazF toxin-antitoxin (TA) module that mediates programmed cell death (PCD). This is achieved by lowering the cellular concentration of (p)ppGpp produced by RelA under amino acid starvation%2C thus protecting the cell from the toxicity of MazF. Reduction of (p)ppGpp can be achieved by direct degradation of (p)ppGpp or by degradation of NTPs%2C which are substrates for (p)ppGpp synthesis by RelA (By similarity)%3B Belongs to the nucleoside triphosphate pyrophosphohydrolase family%3B KEGG: vch:VC2450 ATP diphosphatase gene gene2640 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02641 VSVS12_02642 VSVS12_02642 relA relA 2909933 2912155 - GTP diphosphokinase In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which is then hydrolyzed to form ppGpp. Plays also a role in the reductive division that occurs during the initial phase of nutrient starvation. Belongs to the RelA/SpoT family%3B Contains 1 ACT domain%3B KEGG: vch:VC2451 GTP pyrophosphokinase gene gene2641 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02642 VSVS12_02643 VSVS12_02643 rumA rumA 2912231 2913559 - 23S rRNA (uracil(1939)-C(5))-methyltransferase Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA%3B Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. RlmD subfamily%3B Contains 1 TRAM domain%3B KEGG: vch:VC2452 23S rRNA (uracil1939-C5)-methyltransferase gene gene2642 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02643 VSVS12_02644 VSVS12_02644 barA barA 2913718 2916507 + Histidine kinase Member of the two-component regulatory system UvrY/BarA involved in the regulation of carbon metabolism via the CsrA/CsrB regulatory system. Phosphorylates UvrY%2C probably via a four-step phosphorelay (By similarity)%3B Contains 1 HAMP domain%3B Contains 1 histidine kinase domain%3B Contains 1 HPt domain%3B Contains 1 response regulatory domain%3B KEGG: vvu:VV1_1573 two-component system%2C NarL family%2C sensor histidine kinase BarA gene gene2643 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02644 VSVS12_02645 VSVS12_02645 acpS acpS 2916582 2916965 - Holo-[acyl-carrier-protein] synthase Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein%3B Belongs to the P-Pant transferase superfamily. AcpS family%3B KEGG: eco:b2563 holo-(acyl-carrier protein) synthase gene gene2644 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02645 VSVS12_02646 VSVS12_02646 pdxJ pdxJ 2916969 2917700 - Pyridoxine 5'-phosphate synthase Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate%3B Belongs to the PNP synthase family%3B KEGG: vch:VC2458 pyridoxine 5-phosphate synthase gene gene2645 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02646 VSVS12_02647 VSVS12_02647 VSVS12_02647 2917697 2918422 - DNA repair protein RecO Involved in DNA repair and RecF pathway recombination%3B Belongs to the RecO family gene gene2646 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02647 VSVS12_02648 VSVS12_02648 VSVS12_02648 2918513 2919493 - GTPase Era An essential GTPase that binds both GDP and GTP%2C with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism%3B Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin- like GTPase superfamily. Era GTPase family%3B Contains 1 Era-type G (guanine nucleotide-binding) domain%3B Contains 1 KH type-2 domain gene gene2647 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02648 VSVS12_02649 VSVS12_02649 rnt1 rnt1 2919486 2920163 - Ribonuclease III Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs%2C and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism%3B Contains 1 DRBM (double-stranded RNA-binding) domain%3B Contains 1 RNase III domain%3B KEGG: vcy:IX92_01770 ribonuclease III gene gene2648 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02649 VSVS12_02650 VSVS12_02650 lepB lepB 2920179 2921075 - Signal peptidase I Belongs to the peptidase S26 family%3B KEGG: plu:plu3341 signal peptidase I gene gene2649 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02650 VSVS12_02651 VSVS12_02651 VSVS12_02651 2921166 2922959 - Elongation factor Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction%2C by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex%2C thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner%3B Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily%3B Contains 1 tr-type G (guanine nucleotide-binding) domain gene gene2650 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02651 VSVS12_02652 VSVS12_02652 VSVS12_02652 2923074 2923544 - hypothetical protein gene gene2651 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02652 VSVS12_02653 VSVS12_02653 VSVS12_02653 2923541 2924521 - Sigma-E factor regulatory protein Negatively modulates the activity of sigma-E (RpoE) by stabilizing RseA under non-stress conditions. Although not essential for association of sigma-E with Rsea it increases their affinity 2- to 3-fold. When bound to RseA it prevents proteolysis by DegS%2C which is probably relieved by lipopolysaccharide binding (LPS) (By similarity)%3B Belongs to the RseB family gene gene2652 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02653 VSVS12_02654 VSVS12_02654 VSVS12_02654 2924518 2925150 - Anti-sigma-E factor RseA An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal (periplasmic or acid stress or heat shock) triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease%2C S1P%2C DegS)%2C then within the membrane itself (site-2 protease%2C S2P%2C RseP)%2C while cytoplasmic proteases finish degrading the anti-sigma factor%2C liberating sigma-E (Probable). In this organism acid stress response does not require DegS degradation%3B Belongs to the RseA family gene gene2653 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02654 VSVS12_02655 VSVS12_02655 VSVS12_02655 2925161 2925739 - ECF RNA polymerase sigma-E factor Sigma factors are initiation factors that promote the attachment of RNA polymerase (RNAP) to specific initiation sites and are then released. Extracytoplasmic function (ECF) sigma-E controls the envelope stress response%2C responding to periplasmic protein stress%2C increased levels of periplasmic lipopolysaccharide (LPS) as well as heat shock and oxidative stres%3B it controls protein processing in the extracytoplasmic compartment (By similarity)%3B Belongs to the sigma-70 factor family. ECF subfamily gene gene2654 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02655 VSVS12_02656 VSVS12_02656 nadB nadB 2926054 2927670 + L-aspartate oxidase Catalyzes the oxidation of L-aspartate to iminoaspartate. Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily%3B KEGG: vch:VC2469 L-aspartate oxidase gene gene2655 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02656 VSVS12_02657 VSVS12_02657 VSVS12_02657 2927707 2928021 - hypothetical protein gene gene2656 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02657 VSVS12_02658 VSVS12_02658 VSVS12_02658 2928089 2928349 - uncharacterized protein Belongs to the CptB antitoxin family gene gene2657 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02658 VSVS12_02659 VSVS12_02659 VSVS12_02659 2928596 2929576 + tRNA-modifying protein YgfZ Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification%2C such as initiation of chromosomal replication%3B Belongs to the tRNA-modifying YgfZ family gene gene2658 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02659 VSVS12_02660 VSVS12_02660 VSVS12_02660 2929566 2930042 + hypothetical protein gene gene2659 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02660 VSVS12_02661 VSVS12_02661 VSVS12_02661 2930640 2930846 + uncharacterized protein gene gene2660 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02661 VSVS12_02662 VSVS12_02662 ubiI ubiI 2930970 2932196 - 2-octaprenylphenol hydroxylase FAD-dependent monooxygenase required for the aerobic hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy- phenol%2C the first hydroxylation step in coenzyme Q (ubiquinone) biosynthesis%3B Belongs to the UbiH/COQ6 family%3B KEGG: vvu:VV1_1553 2-octaprenylphenol hydroxylase%3B With NADH or NADPH as one donor%2C and incorporation of one atom of oxygen gene gene2661 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02662 VSVS12_02663 VSVS12_02663 ubiH ubiH 2932218 2933396 - 2-octaprenyl-6-methoxyphenol hydroxylase Is likely an oxygenase that introduces the hydroxyl group at carbon four of 2-octaprenyl-6-methoxyphenol resulting in the formation of 2-octaprenyl-6-methoxy-1%2C4-benzoquinol%3B Belongs to the UbiH/COQ6 family%3B KEGG: mvr:X781_16520 2-octaprenyl-6-methoxyphenol hydroxylase%3B With NADH or NADPH as one donor%2C and incorporation of one atom of oxygen gene gene2662 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02663 VSVS12_02664 VSVS12_02664 VSVS12_02664 2933410 2933988 - UPF0149 protein Belongs to the UPF0149 family gene gene2663 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02664 VSVS12_02665 VSVS12_02665 VSVS12_02665 2934225 2934548 + Cell division protein ZapA Activator of cell division through the inhibition of FtsZ GTPase activity%2C therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division%3B Belongs to the ZapA family. Type 1 subfamily gene gene2664 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02665 VSVS12_02666 VSVS12_02666 VSVS12_02666 2934833 2935426 + 5-formyltetrahydrofolate cyclo-ligase Involved in the removal of 5-formyltetrahydrofolate. In vitro%2C it is a potent inhibitor of various folate-dependent enzymes in the C1 metabolism network and in vivo it might function as a folate storage. 5-formyltetrahydrofolate is also used as an antifolate rescue agent in cancer chemotherapy. Catalyzes the irreversible ATP-dependent transformation of 5- formyltetrahydrofolate (5-CHO-THF) to form 5%2C10- methenyltetrahydrofolate (5%2C10-CH%3DTHF). The reverse reaction is catalyzed by the serine hydroxymethyltransferase GlyA (SHMT) (By similarity)%3B Belongs to the 5-formyltetrahydrofolate cyclo-ligase family%3B KEGG: vcy:IX92_01685 5-formyltetrahydrofolate cyclo-ligase gene gene2665 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02666 VSVS12_02667 VSVS12_02667 rpiA rpiA 2935480 2936136 + Ribose-5-phosphate isomerase Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate%3B Belongs to the ribose 5-phosphate isomerase family%3B KEGG: eco:b2914 ribose 5-phosphate isomerase A gene gene2666 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02667 VSVS12_02668 VSVS12_02668 serA serA 2936462 2937691 + Phosphoglycerate dehydrogenase Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family%3B Contains 1 ACT domain%3B KEGG: eco:b2913 D-3-phosphoglycerate dehydrogenase gene gene2667 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02668 VSVS12_02669 VSVS12_02669 ilvH ilvH 2937787 2938281 - Acetolactate synthase Belongs to the acetolactate synthase small subunit family%3B Contains 1 ACT domain%3B KEGG: vch:VC2482 acetolactate synthase I/III small subunit gene gene2668 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02669 VSVS12_02670 VSVS12_02670 VSVS12_02670 2938283 2940007 - Acetolactate synthase Belongs to the TPP enzyme family%3B KEGG: vvu:VV1_0648 acetolactate synthase I/II/III large subunit gene gene2669 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02670 VSVS12_02671 VSVS12_02671 VSVS12_02671 2940427 2942235 - Long-chain-fatty-acid--CoA ligase Mediates activation of long-chain fatty acids for both synthesis of cellular lipids%2C and degradation via beta-oxidation. Able to activate long-chain fatty acids. Can activate diverse saturated%2C monosaturated and polyunsaturated fatty acids (By similarity)%3B Belongs to the ATP-dependent AMP-binding enzyme family. Bubblegum subfamily%3B KEGG: vch:VC2484 long-chain acyl-CoA synthetase gene gene2670 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02671 VSVS12_02672 VSVS12_02672 VSVS12_02672 2942441 2943409 - HTH-type transcriptional regulator LeuO A global transcription factor. Activates transcription of the 9 following operon%3B yjjQ-bglJ%2C yjjP%2C acrEF%2C ybdO%2C yjcRQP%2C casABCDE12%2C rhsD-ybbC%2C fepE and gltF%2C in most cases it probably interferes with silencing by H-NS and activates transcription. Represses transcription of the 3 following operon%3B uxaCA%2C sdaCB and yjiY. H-NS repression of the bgl operon%2C leading to the ability to metabolize some beta-glucosides. It also directly activates the bgl operon. Activation is H-NS and BglJ-RcsB independent%3B Contains 1 HTH lysR-type DNA-binding domain gene gene2671 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02672 VSVS12_02673 VSVS12_02673 leuA leuA 2944449 2945996 + 2-isopropylmalate synthase Catalyzes the condensation of alpha-ketoglutarate and acetyl-CoA to form trans-homoaconitate. Can also catalyze the condensation of alpha-ketoadipate with acetyl-CoA to form (R)- homo(2)citrate%2C and the condensation of alpha-ketopimelate with acetyl-CoA to form (R)-homo(3)citrate (By similarity)%3B Belongs to the alpha-IPM synthase/homocitrate synthase family%3B KEGG: eco:b0074 2-isopropylmalate synthase gene gene2672 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02673 VSVS12_02674 VSVS12_02674 leuB leuB 2946108 2947199 + 3-isopropylmalate dehydrogenase Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate%3B Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily%3B KEGG: vvu:VV1_0655 3-isopropylmalate dehydrogenase gene gene2673 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02674 VSVS12_02675 VSVS12_02675 leuC leuC 2947359 2948759 + 3-isopropylmalate dehydratase Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate%2C via the formation of 2-isopropylmaleate%3B Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily%3B KEGG: eco:b0072 3-isopropylmalate/(R)-2-methylmalate dehydratase large subunit gene gene2674 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02675 VSVS12_02676 VSVS12_02676 leuD leuD 2948771 2949373 + 3-isopropylmalate dehydratase Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate%2C via the formation of 2-isopropylmaleate%3B Belongs to the LeuD family. LeuD type 1 subfamily%3B KEGG: gan:UMN179_00671 3-isopropylmalate/(R)-2-methylmalate dehydratase small subunit gene gene2675 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02676 VSVS12_02677 VSVS12_02677 VSVS12_02677 2949507 2950301 + hypothetical protein gene gene2676 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02677 VSVS12_02678 VSVS12_02678 VSVS12_02678 2950424 2950539 - 5S ribosomal RNA rRNA gene2677 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02678 VSVS12_02679 VSVS12_02679 VSVS12_02679 2950556 2950631 - tRNA-Thr tRNA gene2678 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02679 VSVS12_02680 VSVS12_02680 VSVS12_02680 2950732 2950847 - 5S ribosomal RNA rRNA gene2679 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02680 VSVS12_02681 VSVS12_02681 VSVS12_02681 2950940 2953833 - 23S ribosomal RNA rRNA gene2680 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02681 VSVS12_02682 VSVS12_02682 VSVS12_02682 2954113 2954188 - tRNA-Ala tRNA gene2681 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02682 VSVS12_02683 VSVS12_02683 VSVS12_02683 2954231 2954307 - tRNA-Ile tRNA gene2682 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02683 VSVS12_02684 VSVS12_02684 VSVS12_02684 2954375 2955921 - 16S ribosomal RNA rRNA gene2683 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02684 VSVS12_02685 VSVS12_02685 VSVS12_02685 2956481 2957737 - uncharacterized protein Contains 1 GGDEF domain%3B Contains 1 HD domain gene gene2684 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02685 VSVS12_02686 VSVS12_02686 VSVS12_02686 2957847 2958254 - Protein PhnB gene gene2685 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02686 VSVS12_02687 VSVS12_02687 VSVS12_02687 2958327 2959325 - Catabolite control protein Transcriptional regulator involved in catabolite repression of several operons. Contains 1 HTH lacI-type DNA-binding domain gene gene2686 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02687 VSVS12_02688 VSVS12_02688 chbG chbG 2959434 2960168 - Chitin disaccharide deacetylase Probably catalyzes the deacetylation of acetylated carbohydrates an important step in the degradation of oligosaccharides%3B Belongs to the YdjC deacetylase family%3B KEGG: vch:VC1285 chitin disaccharide deacetylase gene gene2687 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02688 VSVS12_02689 VSVS12_02689 celF celF 2960207 2961529 - 6-phospho-beta-glucosidase Hydrolyzes cellobiose 6'-phosphate into glucose 6- phosphate (Glc6P) and glucose. Belongs to the glycosyl hydrolase 4 family%3B KEGG: efa:EF1411 6-phospho-beta-glucosidase gene gene2688 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02689 VSVS12_02690 VSVS12_02690 VSVS12_02690 2961542 2961850 - Protein-N(pi)-phosphohistidine--sugar phosphotransferase The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS)%2C a major carbohydrate active -transport system%2C catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. This system is involved in N%2CN'-diacetylchitobiose transport (By similarity)%3B Contains 1 PTS EIIA type-3 domain%3B KEGG: vch:VC1283 PTS system%2C cellobiose-specific IIA component gene gene2689 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02690 VSVS12_02691 VSVS12_02691 VSVS12_02691 2961895 2963226 - Oligo-beta-mannoside permease IIC component The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS)%2C a major carbohydrate active -transport system%2C catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in the transport of oligo- glucomannans such as cellobiose or mannobiose (Probable)%3B Contains 1 PTS EIIC type-3 domain gene gene2690 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02691 VSVS12_02692 VSVS12_02692 VSVS12_02692 2963327 2963632 - Protein-N(pi)-phosphohistidine--sugar phosphotransferase The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS)%2C a major carbohydrate active -transport system%2C catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in the transport of oligo- glucomannans such as cellobiose or mannobiose (Probable)%3B Contains 1 PTS EIIB type-3 domain%3B KEGG: efe:EFER_3956 PTS system%2C cellobiose-specific IIB component gene gene2691 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02692 VSVS12_02693 VSVS12_02693 VSVS12_02693 2963925 2965565 - Methyl-accepting chemotaxis protein NahY Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment%2C transduce a signal from the outside to the inside of the cell%2C and facilitate sensory adaptation through the variation of the level of methylation. Chemoreceptor for naphthalene or a related compound. May facilitate biodegradation%3B Contains 1 HAMP domain%3B Contains 1 methyl-accepting transducer domain gene gene2692 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02693 VSVS12_02694 VSVS12_02694 VSVS12_02694 2965907 2967115 + hypothetical protein gene gene2693 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02694 VSVS12_02695 VSVS12_02695 VSVS12_02695 2967450 2968658 + hypothetical protein gene gene2694 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02695 VSVS12_02696 VSVS12_02696 VSVS12_02696 2968818 2969474 + Inorganic diphosphatase KEGG: dds:Ddes_1854 inorganic pyrophosphatase gene gene2695 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02696 VSVS12_02697 VSVS12_02697 VSVS12_02697 2969604 2970521 - hypothetical protein gene gene2696 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02697 VSVS12_02698 VSVS12_02698 VSVS12_02698 2970621 2970746 - hypothetical protein gene gene2697 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02698 VSVS12_02699 VSVS12_02699 VSVS12_02699 2971215 2972342 - hypothetical protein gene gene2698 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02699 VSVS12_02700 VSVS12_02700 VSVS12_02700 2972343 2973773 - hypothetical protein gene gene2699 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02700 VSVS12_02701 VSVS12_02701 VSVS12_02701 2973826 2974428 - hypothetical protein gene gene2700 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02701 VSVS12_02702 VSVS12_02702 VSVS12_02702 2974443 2975765 - hypothetical protein gene gene2701 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02702 VSVS12_02703 VSVS12_02703 VSVS12_02703 2976094 2976702 - hypothetical protein gene gene2702 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02703 VSVS12_02704 VSVS12_02704 VSVS12_02704 2976812 2977048 - Ribonuclease H KEGG: dsf:UWK_01133 ribonuclease HI gene gene2703 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02704 VSVS12_02705 VSVS12_02705 VSVS12_02705 2977360 2980059 - hypothetical protein gene gene2704 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02705 VSVS12_02706 VSVS12_02706 VSVS12_02706 2980122 2980562 - hypothetical protein gene gene2705 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02706 VSVS12_02707 VSVS12_02707 VSVS12_02707 2980656 2980838 - hypothetical protein gene gene2706 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02707 VSVS12_02708 VSVS12_02708 VSVS12_02708 2980848 2982011 - Tyrosine recombinase XerC Site-specific tyrosine recombinase%2C which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids%3B Belongs to the 'phage' integrase family. XerC subfamily gene gene2707 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02708 VSVS12_02709 VSVS12_02709 VSVS12_02709 2982114 2983583 + hypothetical protein gene gene2708 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02709 VSVS12_02710 VSVS12_02710 VSVS12_02710 2983734 2983934 - hypothetical protein gene gene2709 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02710 VSVS12_02711 VSVS12_02711 VSVS12_02711 2984018 2984155 - hypothetical protein gene gene2710 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02711 VSVS12_02712 VSVS12_02712 VSVS12_02712 2984470 2985399 + putative HTH-type transcriptional regulator YfjR Contains 1 HTH deoR-type DNA-binding domain gene gene2711 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02712 VSVS12_02713 VSVS12_02713 VSVS12_02713 2985459 2985575 - hypothetical protein gene gene2712 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02713 VSVS12_02714 VSVS12_02714 VSVS12_02714 2985928 2986356 - hypothetical protein gene gene2713 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02714 VSVS12_02715 VSVS12_02715 VSVS12_02715 2986717 2987925 - hypothetical protein gene gene2714 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02715 VSVS12_02716 VSVS12_02716 VSVS12_02716 2987985 2988296 - hypothetical protein gene gene2715 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02716 VSVS12_02717 VSVS12_02717 VSVS12_02717 2988341 2988724 - hypothetical protein gene gene2716 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02717 VSVS12_02718 VSVS12_02718 VSVS12_02718 2988817 2990055 - hypothetical protein gene gene2717 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02718 VSVS12_02719 VSVS12_02719 VSVS12_02719 2990151 2990540 - hypothetical protein gene gene2718 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02719 VSVS12_02720 VSVS12_02720 VSVS12_02720 2991956 2993134 + hypothetical protein gene gene2719 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02720 VSVS12_02721 VSVS12_02721 VSVS12_02721 2993174 2994025 - hypothetical protein gene gene2720 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02721 VSVS12_02722 VSVS12_02722 VSVS12_02722 2994275 2994496 - hypothetical protein gene gene2721 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02722 VSVS12_02723 VSVS12_02723 VSVS12_02723 2994489 2994698 - hypothetical protein gene gene2722 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02723 VSVS12_02724 VSVS12_02724 VSVS12_02724 2994859 2996484 + hypothetical protein gene gene2723 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02724 VSVS12_02725 VSVS12_02725 VSVS12_02725 2996699 2996956 - hypothetical protein gene gene2724 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02725 VSVS12_02726 VSVS12_02726 VSVS12_02726 2996956 2998287 - hypothetical protein gene gene2725 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02726 VSVS12_02727 VSVS12_02727 VSVS12_02727 2998414 2998575 + hypothetical protein gene gene2726 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02727 VSVS12_02728 VSVS12_02728 VSVS12_02728 2998559 2998828 + hypothetical protein gene gene2727 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02728 VSVS12_02729 VSVS12_02729 VSVS12_02729 2998831 2999112 + hypothetical protein gene gene2728 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02729 VSVS12_02730 VSVS12_02730 VSVS12_02730 2999115 2999240 + hypothetical protein gene gene2729 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02730 VSVS12_02731 VSVS12_02731 VSVS12_02731 2999321 2999482 + hypothetical protein gene gene2730 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02731 VSVS12_02732 VSVS12_02732 VSVS12_02732 2999556 2999675 + hypothetical protein gene gene2731 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02732 VSVS12_02733 VSVS12_02733 VSVS12_02733 2999685 3001448 + hypothetical protein gene gene2732 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02733 VSVS12_02734 VSVS12_02734 VSVS12_02734 3001460 3001771 + hypothetical protein gene gene2733 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02734 VSVS12_02735 VSVS12_02735 VSVS12_02735 3001771 3002952 + hypothetical protein gene gene2734 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02735 VSVS12_02736 VSVS12_02736 VSVS12_02736 3003013 3003285 - hypothetical protein gene gene2735 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02736 VSVS12_02737 VSVS12_02737 VSVS12_02737 3003401 3003485 - tRNA-Leu tRNA gene2736 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02737 VSVS12_02738 VSVS12_02738 VSVS12_02738 3003817 3004293 + hypothetical protein gene gene2737 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02738 VSVS12_02739 VSVS12_02739 luxS luxS 3004386 3004904 - S-ribosylhomocysteine lyase Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4%2C5- dihydroxy-2%2C3-pentadione (DPD)%3B Belongs to the LuxS family%3B KEGG: eco:b2687 S-ribosylhomocysteine lyase gene gene2738 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02739 VSVS12_02740 VSVS12_02740 VSVS12_02740 3004922 3005533 - hypothetical protein gene gene2739 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02740 VSVS12_02741 VSVS12_02741 gshA gshA 3005550 3007115 - Glutamate--cysteine ligase Belongs to the glutamate--cysteine ligase type 1 family. Type 1 subfamily%3B KEGG: vvu:VV1_1606 glutamate--cysteine ligase gene gene2740 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02741 VSVS12_02742 VSVS12_02742 VSVS12_02742 3007224 3010082 - putative zinc protease Belongs to the peptidase M16 family%3B KEGG: vsp:VS_2565 zinc protease%3B Metalloendopeptidases gene gene2741 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02742 VSVS12_02743 VSVS12_02743 VSVS12_02743 3010092 3010553 - Inner membrane protein YqaA To H. influenzae HI_0489 gene gene2742 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02743 VSVS12_02744 VSVS12_02744 cryZ cryZ 3010547 3011497 - NADPH:quinone reductase Catalyzes the reduction of succinate semialdehyde to succinyl-CoA. The enzyme is specific for succinate semialdehyde and succinyl-CoA%2C and only shows low activity with palmitoyl-CoA. There is no activity with NAD(+) as cosubstrate. Participates in the 3-hydroxypropanoate/4-hydroxybutyrate cycle%2C an autotrophic CO(2) fixation pathway found in some thermoacidophilic archaea%3B Belongs to the zinc-containing alcohol dehydrogenase family%3B KEGG: vvu:VV1_1603 NADPH2:quinone reductase gene gene2743 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02744 VSVS12_02745 VSVS12_02745 oadB oadB 3011635 3012765 - Oxaloacetate decarboxylase Tunnel subunit of the primary sodium pump glutaconyl-CoA decarboxylase (GCD). Belongs to the GcdB/MmdB/OadB family%3B KEGG: mvr:X781_19090 oxaloacetate decarboxylase%2C beta subunit gene gene2744 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02745 VSVS12_02746 VSVS12_02746 oadA oadA 3012775 3014553 - Oxaloacetate decarboxylase The 5S subunit specifically catalyzes the transfer of the carboxyl group from biotin of the 1. 3S subunit to pyruvate to form oxaloacetate and 1. 3S biotin. Contains 1 carboxyltransferase domain%3B KEGG: vch:VC0550 oxaloacetate decarboxylase%2C alpha subunit gene gene2745 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02746 VSVS12_02747 VSVS12_02747 oadG oadG 3014585 3014839 - Oxaloacetate decarboxylase Lyase and sodium transporter%3B Belongs to the OadG family%3B KEGG: vcy:IX92_01335 oxaloacetate decarboxylase%2C gamma subunit gene gene2746 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02747 VSVS12_02748 VSVS12_02748 VSVS12_02748 3015281 3015357 - tRNA-Arg tRNA gene2747 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02748 VSVS12_02749 VSVS12_02749 VSVS12_02749 3015428 3015504 - tRNA-Arg tRNA gene2748 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02749 VSVS12_02750 VSVS12_02750 VSVS12_02750 3015575 3015651 - tRNA-Arg tRNA gene2749 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02750 VSVS12_02751 VSVS12_02751 VSVS12_02751 3015722 3015798 - tRNA-Arg tRNA gene2750 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02751 VSVS12_02752 VSVS12_02752 VSVS12_02752 3015874 3015950 - tRNA-Arg tRNA gene2751 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02752 VSVS12_02753 VSVS12_02753 VSVS12_02753 3016018 3016110 - tRNA-Ser tRNA gene2752 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02753 VSVS12_02754 VSVS12_02754 VSVS12_02754 3016135 3016211 - tRNA-Arg tRNA gene2753 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02754 VSVS12_02755 VSVS12_02755 VSVS12_02755 3016281 3016373 - tRNA-Ser tRNA gene2754 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02755 VSVS12_02756 VSVS12_02756 VSVS12_02756 3016557 3016754 - Carbon storage regulator like protein Could accelerate the degradation of some genes transcripts potentially through selective RNA binding%3B Belongs to the CsrA family gene gene2755 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02756 VSVS12_02757 VSVS12_02757 VSVS12_02757 3016831 3018021 - Aspartate kinase Catalyzes the phosphorylation of the beta-carboxyl group of aspartic acid with ATP to yield 4-phospho-L-aspartate%2C which is involved in the branched biosynthetic pathway leading to the biosynthesis of amino acids threonine%2C isoleucine and methionine%3B Belongs to the aspartokinase family%3B Contains 2 ACT domains%3B KEGG: vch:VC0547 aspartate kinase gene gene2756 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02757 VSVS12_02758 VSVS12_02758 VSVS12_02758 3018173 3020755 - Alanine--tRNA ligase Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain%3B Belongs to the class-II aminoacyl-tRNA synthetase family%3B KEGG: vch:VC0545 alanyl-tRNA synthetase gene gene2757 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02758 VSVS12_02759 VSVS12_02759 VSVS12_02759 3021116 3022156 - Protein RecA It interacts with LexA causing its activation and leading to its autocatalytic cleavage. Belongs to the RecA family gene gene2758 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02759 VSVS12_02760 VSVS12_02760 VSVS12_02760 3022371 3022859 - Nicotinamide-nucleotide amidase Belongs to the CinA family%3B KEGG: sma:SAV_2506 nicotinamide-nucleotide amidase gene gene2759 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02760 VSVS12_02761 VSVS12_02761 VSVS12_02761 3022944 3025511 + DNA mismatch repair protein MutS This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity%3B Belongs to the DNA mismatch repair MutS family gene gene2760 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02761 VSVS12_02762 VSVS12_02762 VSVS12_02762 3025774 3026232 + Fimbrial protein Belongs to the N-Me-Phe pilin family gene gene2761 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02762 VSVS12_02763 VSVS12_02763 VSVS12_02763 3026232 3027914 + Type 4 fimbrial assembly protein PilB Involved in the translocation of the type IV pilin (PilA). Belongs to the GSP E family gene gene2762 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02763 VSVS12_02764 VSVS12_02764 VSVS12_02764 3027968 3029191 + Type IV pilin assembly protein PilC Involved in the translocation of the type IV pilin. Belongs to the GSP F family gene gene2763 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02764 VSVS12_02765 VSVS12_02765 gspO gspO 3029578 3030165 + Type 4 prepilin-like protein leader peptide-processing enzyme Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue%3B Belongs to the peptidase A24 family%3B KEGG: yen:YE3574 general secretion pathway protein O%3B Prepilin peptidase gene gene2764 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02765 VSVS12_02766 VSVS12_02766 coaE coaE 3030170 3030778 + Dephospho-CoA kinase Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A%3B Belongs to the CoaE family%3B Contains 1 DPCK (dephospho-CoA kinase) domain%3B KEGG: vch:VC2427 dephospho-CoA kinase gene gene2765 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02766 VSVS12_02767 VSVS12_02767 VSVS12_02767 3030813 3031553 + Cell division protein ZapD Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments%2C with a reduction in FtsZ GTPase activity%3B Belongs to the ZapD family gene gene2766 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02767 VSVS12_02768 VSVS12_02768 VSVS12_02768 3031629 3031823 + DNA gyrase inhibitor YacG Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB%2C which probably disrupts DNA binding by the gyrase%3B Belongs to the DNA gyrase inhibitor YacG family gene gene2767 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02768 VSVS12_02769 VSVS12_02769 VSVS12_02769 3032182 3032535 - 50S ribosomal protein L19%2C chloroplastic Belongs to the ribosomal protein L19P family gene gene2768 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02769 VSVS12_02770 VSVS12_02770 trmD trmD 3032585 3033334 - tRNA (guanine(37)-N(1))-methyltransferase Specifically methylates guanosine-37 in various tRNAs%3B Belongs to the RNA methyltransferase TrmD family%3B KEGG: eco:b2607 tRNA (guanine37-N1)-methyltransferase gene gene2769 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02770 VSVS12_02771 VSVS12_02771 VSVS12_02771 3033362 3033916 - Ribosome maturation factor RimM An accessory protein needed during the final step in the assembly of 30S ribosomal subunit%2C possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes%3B Belongs to the RimM family%3B Contains 1 PRC barrel domain gene gene2770 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02771 VSVS12_02772 VSVS12_02772 VSVS12_02772 3033941 3034189 - 30S ribosomal protein S16 Belongs to the ribosomal protein S16P family gene gene2771 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02772 VSVS12_02773 VSVS12_02773 VSVS12_02773 3034401 3035780 - Signal recognition particle protein Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane%2C the hydrolysis of GTP by both Ffh and FtsY%2C and the dissociation of the SRP-FtsY complex into the individual components%3B Belongs to the GTP-binding SRP family. SRP54 subfamily gene gene2772 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02773 VSVS12_02774 VSVS12_02774 VSVS12_02774 3035963 3036757 + Inner membrane protein YpjD gene gene2773 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02774 VSVS12_02775 VSVS12_02775 VSVS12_02775 3036886 3038160 + UPF0053 inner membrane protein YfjD Belongs to the UPF0053 family%3B Contains 2 CBS domains%3B Contains 1 DUF21 domain gene gene2774 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02775 VSVS12_02776 VSVS12_02776 VSVS12_02776 3038333 3039316 - RNA polymerase sigma factor RpoS Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the master transcriptional regulator of the stationary phase and the general stress response (By similarity). May be required for the persistence of V. cholerae in aquatic habitats%3B Belongs to the sigma-70 factor family. RpoS subfamily gene gene2775 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02776 VSVS12_02777 VSVS12_02777 VSVS12_02777 3039394 3040314 - Outer membrane antigenic lipoprotein May be a virulence determinant. Belongs to the E. coli NlpD/Haemophilus LppB family%3B Contains 1 LysM repeat gene gene2776 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02777 VSVS12_02778 VSVS12_02778 VSVS12_02778 3040317 3040943 - Protein-L-isoaspartate(D-aspartate) O-methyltransferase Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins%3B Belongs to the methyltransferase superfamily. L- isoaspartyl/D-aspartyl protein methyltransferase family%3B KEGG: vpa:VP2555 protein-L-isoaspartate(D-aspartate) O-methyltransferase gene gene2777 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02778 VSVS12_02779 VSVS12_02779 surE surE 3040947 3041720 - 5'-nucleotidase Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates%3B Belongs to the SurE nucleotidase family%3B KEGG: vfu:vfu_A02985 5'-nucleotidase gene gene2778 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02779 VSVS12_02780 VSVS12_02780 truD truD 3041717 3042811 - tRNA pseudouridine(13) synthase Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs%3B Belongs to the pseudouridine synthase TruD family%3B Contains 1 TRUD domain%3B KEGG: vch:VC0530 tRNA pseudouridine13 synthase gene gene2779 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02780 VSVS12_02781 VSVS12_02781 ispF ispF 3042871 3043347 - 2-C-methyl-D-erythritol 2%2C4-cyclodiphosphate synthase Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl- D-erythritol 4-phosphate (MEP) (IspD)%2C and catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2- phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2%2C4- cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF)%3B In the N-terminal sectio%3B belongs to the IspD family%3B In the C-terminal sectio%3B belongs to the IspF family%3B KEGG: eco:b2746 2-C-methyl-D-erythritol 2%2C4-cyclodiphosphate synthase gene gene2780 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02781 VSVS12_02782 VSVS12_02782 ispD ispD 3043354 3044076 - 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP)%3B Belongs to the IspD family%3B KEGG: gni:GNIT_2916 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase gene gene2781 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02782 VSVS12_02783 VSVS12_02783 VSVS12_02783 3044076 3044357 - Cell division protein FtsB Essential cell division protein. May link together the upstream cell division proteins%2C which are predominantly cytoplasmic%2C with the downstream cell division proteins%2C which are predominantly periplasmic%3B Belongs to the FtsB family gene gene2782 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02783 VSVS12_02784 VSVS12_02784 bacA bacA 3044462 3045265 - Undecaprenyl-diphosphate phosphatase Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin%3B Belongs to the UppP family%3B KEGG: vvu:VV1_0623 undecaprenyl-diphosphatase gene gene2783 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02784 VSVS12_02785 VSVS12_02785 VSVS12_02785 3045287 3045772 - 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase KEGG: vpa:VP0412 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase gene gene2784 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02785 VSVS12_02786 VSVS12_02786 folB folB 3045769 3046122 - Dihydroneopterin aldolase Catalyzes the conversion of 7%2C8-dihydroneopterin to 6- hydroxymethyl-7%2C8-dihydropterin. Can use L-threo-dihydroneopterin and D-erythro-dihydroneopterin as substrates for the formation of 6-hydroxymethyldihydropterin%2C but it can also catalyze the epimerization of carbon 2' of dihydroneopterin to dihydromonapterin%3B Belongs to the DHNA family%3B KEGG: hin:HI0265 dihydroneopterin aldolase gene gene2785 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02786 VSVS12_02787 VSVS12_02787 plsY plsY 3046271 3046867 + Glycerol-3-phosphate 1-O-acyltransferase Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor%2C but not acyl-CoA or acyl-ACP%3B Belongs to the PlsY family%3B KEGG: ype:YPO0647 glycerol-3-phosphate acyltransferase PlsY gene gene2786 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02787 VSVS12_02788 VSVS12_02788 VSVS12_02788 3046957 3047784 - Pimeloyl-[acyl-carrier protein] methyl ester esterase May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation%3B Belongs to the AB hydrolase superfamily. Hydrolase RutD family%3B KEGG: pca:Pcar_1664 pimeloyl-(acyl-carrier protein) methyl ester esterase gene gene2787 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02788 VSVS12_02789 VSVS12_02789 kae1 kae1 3047922 3048938 - N(6)-L-threonylcarbamoyladenine synthase Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine. Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Involved in mitochondrial genome maintenance (By similarity). May have a role in embryonic development in plants%3B Belongs to the KAE1 / TsaD family%3B KEGG: eco:b3064 N6-L-threonylcarbamoyladenine synthase gene gene2788 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02789 VSVS12_02790 VSVS12_02790 VSVS12_02790 3049418 3049633 + 30S ribosomal protein S21 Belongs to the ribosomal protein S21P family gene gene2789 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02790 VSVS12_02791 VSVS12_02791 VSVS12_02791 3049659 3050102 + uncharacterized protein gene gene2790 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02791 VSVS12_02792 VSVS12_02792 dnaG dnaG 3050249 3052012 + DNA primase RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication%3B Belongs to the DnaG primase family%3B Contains 1 Toprim domain%3B KEGG: vch:VC0518 DNA primase%3B Nucleotidyltransferases gene gene2791 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02792 VSVS12_02793 VSVS12_02793 VSVS12_02793 3052111 3053967 + RNA polymerase sigma factor RpoD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth%3B Belongs to the sigma-70 factor family. RpoD/SigA subfamily gene gene2792 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02793 VSVS12_02794 VSVS12_02794 VSVS12_02794 3054111 3054186 + tRNA-Met tRNA gene2793 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02794 VSVS12_02795 VSVS12_02795 VSVS12_02795 3054333 3055613 + Putative prophage P4 integrase Belongs to the 'phage' integrase family gene gene2794 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02795 VSVS12_02796 VSVS12_02796 VSVS12_02796 3055837 3056661 - Insertion element IS600 uncharacterized 31 kDa protein Contains 1 integrase catalytic domain gene gene2795 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02796 VSVS12_02797 VSVS12_02797 VSVS12_02797 3056694 3056987 - Putative transposase YkgN Belongs to the transposase 8 family gene gene2796 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02797 VSVS12_02798 VSVS12_02798 VSVS12_02798 3057138 3058235 - Sensory rhodopsin II transducer Transduces signals from the phototaxis receptor sensory rhodopsin II (SR-II) to the flagellar motor. Responds to light changes through the variation of the level of methylation. Also acts as a chemotransducer. Contains 2 HAMP domains%3B Contains 1 methyl-accepting transducer domain gene gene2797 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02798 VSVS12_02799 VSVS12_02799 VSVS12_02799 3058326 3058586 - hypothetical protein gene gene2798 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02799 VSVS12_02800 VSVS12_02800 VSVS12_02800 3058610 3058795 - hypothetical protein gene gene2799 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02800 VSVS12_02801 VSVS12_02801 VSVS12_02801 3058758 3059222 - hypothetical protein gene gene2800 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02801 VSVS12_02802 VSVS12_02802 VSVS12_02802 3059176 3059349 - hypothetical protein gene gene2801 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02802 VSVS12_02803 VSVS12_02803 VSVS12_02803 3059361 3060497 - hypothetical protein gene gene2802 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02803 VSVS12_02804 VSVS12_02804 VSVS12_02804 3060500 3061012 - hypothetical protein gene gene2803 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02804 VSVS12_02805 VSVS12_02805 VSVS12_02805 3061151 3062038 - hypothetical protein gene gene2804 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02805 VSVS12_02806 VSVS12_02806 VSVS12_02806 3062038 3064476 - hypothetical protein gene gene2805 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02806 VSVS12_02807 VSVS12_02807 VSVS12_02807 3064498 3065199 - hypothetical protein gene gene2806 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02807 VSVS12_02808 VSVS12_02808 VSVS12_02808 3065301 3065876 - hypothetical protein gene gene2807 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02808 VSVS12_02809 VSVS12_02809 VSVS12_02809 3066461 3066643 - uncharacterized protein To E. coli prophage CP4-57 regulatory protein alpA gene gene2808 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02809 VSVS12_02810 VSVS12_02810 VSVS12_02810 3066804 3067268 + UPF0758 protein Belongs to the UPF0758 family gene gene2809 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02810 VSVS12_02811 VSVS12_02811 VSVS12_02811 3067268 3067711 + hypothetical protein gene gene2810 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02811 VSVS12_02812 VSVS12_02812 VSVS12_02812 3067776 3068255 + hypothetical protein gene gene2811 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02812 VSVS12_02813 VSVS12_02813 VSVS12_02813 3068344 3068559 + hypothetical protein gene gene2812 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02813 VSVS12_02814 VSVS12_02814 VSVS12_02814 3068550 3069233 + hypothetical protein gene gene2813 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02814 VSVS12_02815 VSVS12_02815 VSVS12_02815 3069368 3069538 + hypothetical protein gene gene2814 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02815 VSVS12_02816 VSVS12_02816 VSVS12_02816 3069555 3070292 + hypothetical protein gene gene2815 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02816 VSVS12_02817 VSVS12_02817 VSVS12_02817 3070289 3070648 + hypothetical protein gene gene2816 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02817 VSVS12_02818 VSVS12_02818 VSVS12_02818 3070730 3071161 + hypothetical protein gene gene2817 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02818 VSVS12_02819 VSVS12_02819 VSVS12_02819 3071694 3072632 - hypothetical protein gene gene2818 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02819 VSVS12_02820 VSVS12_02820 VSVS12_02820 3072817 3073452 - uncharacterized protein To E. coli YfjJ gene gene2819 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02820 VSVS12_02821 VSVS12_02821 VSVS12_02821 3074085 3075023 + hypothetical protein gene gene2820 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02821 VSVS12_02822 VSVS12_02822 VSVS12_02822 3075712 3076851 + Response regulator PleD Response regulator that is part of a signal transduction pathway controlling cell differentiation in the swarmer-to-stalked cell transition. Catalyzes the condensation of two GTP molecules to the cyclic dinucleotide di-GMP (c-di-GMP)%2C which acts as a secondary messenger. Contains 1 GGDEF domain%3B Contains 2 response regulatory domains gene gene2821 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02822 VSVS12_02823 VSVS12_02823 VSVS12_02823 3076936 3078315 - Guanine/hypoxanthine permease GhxP High-affinity transporter for guanine and hypoxanthine%3B Belongs to the xanthine/uracil permease family. AzgA purine transporter (TC 2. A. 1. 40) subfamily gene gene2822 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02823 VSVS12_02824 VSVS12_02824 VSVS12_02824 3078721 3079167 + hypothetical protein gene gene2823 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02824 VSVS12_02825 VSVS12_02825 VSVS12_02825 3079317 3081071 + hypothetical protein gene gene2824 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02825 VSVS12_02826 VSVS12_02826 VSVS12_02826 3081337 3082410 + Monocarboxylate 2-oxoacid-binding periplasmic protein Part of the tripartite ATP-independent periplasmic (TRAP) transport system involved in the uptake of monocarboxylate 2-oxoacids. This protein specifically binds monocarboxylate 2- oxoacids including pyruvate%2C 2-oxobutyrate%2C 2-oxovalerate%2C 2- oxoisovalerate%2C 2-oxoisocaproate and 2-oxo-3-methylvalerate. Is not able to bind mannitol%3B Belongs to the bacterial solute-binding protein 7 family gene gene2825 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02826 VSVS12_02827 VSVS12_02827 VSVS12_02827 3082499 3082831 - Multidrug resistance protein EbrB Part of a multidrug efflux pump. Confers resistance to cationic lipophilic dyes such as ethidium bromide%2C acriflavine%2C pyronine Y and safranin O. The efflux is probably coupled to an influx of protons (By similarity)%3B Belongs to the small multidrug resistance (SMR) protein family. EbrA/EbrB (TC 2. A. 7. 1. 6) subfamily gene gene2826 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02827 VSVS12_02828 VSVS12_02828 frmA frmA 3083033 3084181 - S-(hydroxymethyl)glutathione dehydrogenase Oxidizes long-chain aliphatic alcohols%2C long-chain hydroxylated fatty acids and S-hydroxymethylglutathione (hmGSH) in increasing order of preference. Shows little or no activity with short-chain aliphatic alcohols. Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily%3B KEGG: vpa:VPA0071 S-(hydroxymethyl)glutathione dehydrogenase / alcohol dehydrogenase gene gene2827 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02828 VSVS12_02829 VSVS12_02829 VSVS12_02829 3084504 3084893 - hypothetical protein gene gene2828 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02829 VSVS12_02830 VSVS12_02830 bjaI bjaI 3084954 3085517 - Acyl-homoserine-lactone synthase Required for the synthesis of N-butanoyl-L-homoserine lactone (BHL)%2C an autoinducer molecule which binds to AhyR. Belongs to the autoinducer synthase family%3B KEGG: avi:Avi_9666 acyl-homoserine lactone synthase%3B Isovaleryl-homoserine lactone synthase gene gene2829 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02830 VSVS12_02831 VSVS12_02831 VSVS12_02831 3085602 3085994 - hypothetical protein gene gene2830 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02831 VSVS12_02832 VSVS12_02832 VSVS12_02832 3086179 3086901 + Regulatory protein RhlR Necessary for transcriptional activation of the rhlAB genes encoding the rhamnosyltransferase. It also functions as a transcriptional activator of elastase structural gene (lasB). Binds to autoinducer molecules BHL (N-butanoyl-L-homoserine lactone)%2C and HHL (N-hexanoyl-L-homoserine lactone). Belongs to the autoinducer-regulated transcriptional regulatory protein family%3B Contains 1 HTH luxR-type DNA-binding domain gene gene2831 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02832 VSVS12_02833 VSVS12_02833 glmS glmS 3087120 3088952 - Glutamine--fructose-6-phosphate transaminase (isomerizing) Catalyzes the first step in hexosamine metabolism%2C converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source%3B Contains 1 glutamine amidotransferase type-2 domain%3B Contains 2 SIS domains%3B KEGG: eco:b3729 glucosamine--fructose-6-phosphate aminotransferase (isomerizing) gene gene2832 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02833 VSVS12_02834 VSVS12_02834 VSVS12_02834 3089004 3089765 - Galactitol utilization operon repressor Repressor of the gat operon for galacticol transport and metabolism. Contains 1 HTH deoR-type DNA-binding domain gene gene2833 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02834 VSVS12_02835 VSVS12_02835 VSVS12_02835 3090234 3091646 + Pyruvate kinase Belongs to the pyruvate kinase family%3B KEGG: eco:b1676 pyruvate kinase gene gene2834 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02835 VSVS12_02836 VSVS12_02836 VSVS12_02836 3091795 3092556 - uncharacterized protein gene gene2835 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02836 VSVS12_02837 VSVS12_02837 VSVS12_02837 3092600 3093496 - HTH-type transcriptional regulator ArgP Controls the transcription of genes involved in arginine and lysine metabolism%3B Contains 1 HTH lysR-type DNA-binding domain gene gene2836 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02837 VSVS12_02838 VSVS12_02838 VSVS12_02838 3093686 3094270 + Putative amino-acid transporter YggA Belongs to the LysE/ArgO transporter (TC 2. A. 75) family gene gene2837 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02838 VSVS12_02839 VSVS12_02839 VSVS12_02839 3094359 3095225 - putative MscS family protein Belongs to the MscS (TC 1. A. 23) family gene gene2838 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02839 VSVS12_02840 VSVS12_02840 fbaA fbaA 3095545 3096621 - Fructose-bisphosphate aldolase Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3- phosphate (G3P) to form fructose 1%2C6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis%3B Belongs to the class II fructose-bisphosphate aldolase family%3B KEGG: eco:b2925 fructose-bisphosphate aldolase%2C class II gene gene2839 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02840 VSVS12_02841 VSVS12_02841 VSVS12_02841 3096779 3097939 - Phosphoglycerate kinase Belongs to the phosphoglycerate kinase family%3B KEGG: eco:b2926 phosphoglycerate kinase gene gene2840 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02841 VSVS12_02842 VSVS12_02842 VSVS12_02842 3098080 3099114 - Erythrose-4-phosphate dehydrogenase Catalyzes the NAD-dependent conversion of D-erythrose 4- phosphate to 4-phosphoerythronate%3B Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. Epd subfamily%3B KEGG: vch:VC0476 D-erythrose 4-phosphate dehydrogenase gene gene2841 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02842 VSVS12_02843 VSVS12_02843 VSVS12_02843 3099326 3099562 + hypothetical protein gene gene2842 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02843 VSVS12_02844 VSVS12_02844 VSVS12_02844 3099668 3101662 - Transketolase Catalyzes the reversible transfer of a two-carbon ketol group from sedoheptulose-7-phosphate to glyceraldehyde-3- phosphate%2C producing xylulose-5-phosphate and ribose-5-phosphate. Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor%2C via a covalent intermediate with the cofactor thiamine pyrophosphate%3B Belongs to the transketolase family%3B KEGG: eco:b2935 transketolase gene gene2843 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02844 VSVS12_02845 VSVS12_02845 metK metK 3101984 3103138 + Methionine adenosyltransferase Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The overall synthetic reaction is composed of two sequential steps%2C AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme%3B Belongs to the AdoMet synthase family%3B KEGG: eco:b2942 S-adenosylmethionine synthetase gene gene2844 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02845 VSVS12_02846 VSVS12_02846 VSVS12_02846 3103112 3103219 - hypothetical protein gene gene2845 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02846 VSVS12_02847 VSVS12_02847 VSVS12_02847 3103496 3104293 + hypothetical protein gene gene2846 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02847 VSVS12_02848 VSVS12_02848 VSVS12_02848 3104366 3104863 + Protein SprT Belongs to the SprT family%3B Contains 1 SprT-like domain gene gene2847 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02848 VSVS12_02849 VSVS12_02849 endA endA 3104960 3105682 + Deoxyribonuclease I Belongs to the EndA/NucM nuclease family%3B KEGG: son:SO_0833 deoxyribonuclease I gene gene2848 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02849 VSVS12_02850 VSVS12_02850 rsmE rsmE 3105776 3106507 + 16S rRNA (uracil(1498)-N(3))-methyltransferase Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity)%3B Belongs to the RNA methyltransferase RsmE family%3B KEGG: eco:b2946 16S rRNA (uracil1498-N3)-methyltransferase gene gene2849 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02850 VSVS12_02851 VSVS12_02851 gshB gshB 3106520 3107467 + Glutathione synthase Belongs to the prokaryotic GSH synthase family%3B Contains 1 ATP-grasp domain%3B KEGG: eco:b2947 glutathione synthase gene gene2850 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02851 VSVS12_02852 VSVS12_02852 VSVS12_02852 3107552 3108115 + UPF0301 protein Belongs to the UPF0301 (AlgH) family gene gene2851 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02852 VSVS12_02853 VSVS12_02853 ruvX ruvX 3108185 3108595 + Putative pre-16S rRNA nuclease Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA%3B Belongs to the YqgF nuclease family%3B KEGG: eco:b2949 putative holliday junction resolvase%3B Acting on ester bonds gene gene2852 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02853 VSVS12_02854 VSVS12_02854 VSVS12_02854 3108726 3110069 - Metalloprotease Metalloprotease involved in CcdA degradation. Suppresses the inhibitory activity of the carbon storage regulator (CsrA) (By similarity)%3B Belongs to the peptidase U62 family gene gene2853 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02854 VSVS12_02855 VSVS12_02855 VSVS12_02855 3110180 3110707 + UPF0307 protein Belongs to the UPF0307 family gene gene2854 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02855 VSVS12_02856 VSVS12_02856 VSVS12_02856 3110766 3111470 - Spermidine/putrescine import ATP-binding protein PotA Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system%3B Belongs to the ABC transporter superfamily. Spermidine/putrescine importer (TC 3. A. 1. 11. 1) family%3B Contains 1 ABC transporter domain gene gene2855 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02856 VSVS12_02857 VSVS12_02857 VSVS12_02857 3111479 3113071 - Thiamine transport system permease protein ThiP Part of the ABC transporter complex ThiBPQ involved in thiamine import. Probably responsible for the translocation of the substrate across the membrane%3B Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily%3B Contains 2 ABC transmembrane type-1 domains gene gene2856 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02857 VSVS12_02858 VSVS12_02858 VSVS12_02858 3113117 3114124 - Thiamine-binding periplasmic protein Part of the ABC transporter complex ThiBPQ involved in thiamine import%3B Belongs to the bacterial solute-binding protein 1 family gene gene2857 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02858 VSVS12_02859 VSVS12_02859 VSVS12_02859 3114121 3114249 - hypothetical protein gene gene2858 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02859 VSVS12_02860 VSVS12_02860 ubiX ubiX 3114341 3114967 - 4-hydroxy-3-polyprenylbenzoate decarboxylase Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN%3B Belongs to the UbiX/PAD1 family%3B KEGG: son:SO_3804 4-hydroxy-3-polyprenylbenzoate decarboxylase gene gene2859 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02860 VSVS12_02861 VSVS12_02861 VSVS12_02861 3114973 3116325 - UDP-N-acetylmuramate--L-alanyl-gamma-D-glutamyl-meso-2%2C6-diaminoheptandioate ligase Reutilizes the intact tripeptide L-alanyl-gamma-D- glutamyl-meso-diaminopimelate by linking it to UDP-N- acetylmuramate. The enzyme can also use the tetrapeptide L-alanyl- gamma-D-glutamyl-meso-2%2C6-diaminoheptanedioyl-D-alanine or the pentapeptide L-alanyl-gamma-D-glutamyl-meso-2%2C6- diaminoheptandioyl-D-alanyl-D-alanine in vivo and in vitro%3B Belongs to the MurCDEF family. Mpl subfamily%3B KEGG: eco:b4233 UDP-N-acetylmuramate: L-alanyl-gamma-D-glutamyl-meso-diaminopimelate ligase%3B Acid--amino-acid ligases (peptide synthases) gene gene2860 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02861 VSVS12_02862 VSVS12_02862 VSVS12_02862 3116647 3117657 + Fructose-bisphosphatase Belongs to the FBPase class 1 family%3B KEGG: vvu:VV1_0707 fructose-1%2C6-bisphosphatase I gene gene2861 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02862 VSVS12_02863 VSVS12_02863 VSVS12_02863 3117796 3118323 + Inorganic diphosphatase Belongs to the PPase family%3B KEGG: ype:YPO3521 inorganic pyrophosphatase gene gene2862 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02863 VSVS12_02864 VSVS12_02864 VSVS12_02864 3118395 3118757 - hypothetical protein gene gene2863 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02864 VSVS12_02865 VSVS12_02865 VSVS12_02865 3118818 3119165 - Putative gamma-glutamylcyclotransferase Putative gamma-glutamylcyclotransferase%3B Belongs to the gamma-glutamylcyclotransferase family gene gene2864 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02865 VSVS12_02866 VSVS12_02866 VSVS12_02866 3119213 3122983 - Translocation and assembly module TamB Part of the translocation and assembly module (TAM) autotransporter assembly complex%2C which functions in translocation of autotransporters across the outer membrane%3B Belongs to the TamB family gene gene2865 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02866 VSVS12_02867 VSVS12_02867 VSVS12_02867 3122980 3124695 - Translocation and assembly module TamA Part of the translocation and assembly module (TAM) autotransporter assembly complex%2C which functions in translocation of autotransporters across the outer membrane%3B Belongs to the TamA family gene gene2866 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02867 VSVS12_02868 VSVS12_02868 VSVS12_02868 3124822 3125451 + Peptide-methionine (S)-S-oxide reductase Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine%3B Belongs to the MsrA Met sulfoxide reductase family%3B KEGG: vch:VC2549 peptide-methionine (S)-S-oxide reductase gene gene2867 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02868 VSVS12_02869 VSVS12_02869 VSVS12_02869 3125546 3126097 + uncharacterized protein To H. influenzae HI_0045 gene gene2868 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02869 VSVS12_02870 VSVS12_02870 VSVS12_02870 3126167 3126469 + putative 11.6 kDa protein in scrR 3'region gene gene2869 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02870 VSVS12_02871 VSVS12_02871 VSVS12_02871 3126592 3127257 + Trigger factor Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase%3B Belongs to the FKBP-type PPIase family. Tig subfamily%3B Contains 1 PPIase FKBP-type domain gene gene2870 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02871 VSVS12_02872 VSVS12_02872 VSVS12_02872 3127322 3128029 + ATP-binding/permease protein Somehow involved in the cytochrome D branch of aerobic respiration. Seems to be a component of a transport system. Belongs to the ABC transporter superfamily. Cysteine exporter (TC 3. A. 1. 129. 1) family%3B Contains 1 ABC transmembrane type-1 domain%3B Contains 1 ABC transporter domain gene gene2871 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02872 VSVS12_02873 VSVS12_02873 VSVS12_02873 3128026 3128565 + hypothetical protein gene gene2872 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02873 VSVS12_02874 VSVS12_02874 VSVS12_02874 3128605 3129813 + hypothetical protein gene gene2873 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02874 VSVS12_02875 VSVS12_02875 VSVS12_02875 3129880 3130623 + putative ABC transporter permease YvrN Belongs to the ABC-4 integral membrane protein family gene gene2874 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02875 VSVS12_02876 VSVS12_02876 VSVS12_02876 3130626 3131126 + hypothetical protein gene gene2875 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02876 VSVS12_02877 VSVS12_02877 VSVS12_02877 3131238 3131342 - hypothetical protein gene gene2876 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02877 VSVS12_02878 VSVS12_02878 VSVS12_02878 3131621 3132517 + hypothetical protein gene gene2877 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02878 VSVS12_02879 VSVS12_02879 VSVS12_02879 3132658 3134310 - Glucose-6-phosphate isomerase Belongs to the GPI family%3B KEGG: eci:UTI89_C4593 glucose-6-phosphate isomerase gene gene2878 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02879 VSVS12_02880 VSVS12_02880 gen1 gen1 3134586 3135005 + UPF0047 protein Belongs to the UPF0047 family%3B KEGG: smm:Smp_169840 flap endonuclease GEN%3B Acting on ester bonds gene gene2879 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02880 VSVS12_02881 VSVS12_02881 VSVS12_02881 3135082 3136167 - Alanine racemase Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids%3B Belongs to the alanine racemase family%3B KEGG: vch:VC0372 alanine racemase gene gene2880 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02881 VSVS12_02882 VSVS12_02882 dnaB dnaB 3136172 3137584 - DNA helicase Participates in initiation and elongation during chromosome replicatio%3B it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding%2C DNA binding%2C and interaction with DnaC protein%2C primase%2C and other prepriming proteins%3B Belongs to the helicase family. DnaB subfamily%3B Contains 1 SF4 helicase domain%3B KEGG: vcy:IX92_13695 replicative DNA helicase gene gene2881 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02882 VSVS12_02883 VSVS12_02883 VSVS12_02883 3137769 3138530 + hypothetical protein gene gene2882 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02883 VSVS12_02884 VSVS12_02884 VSVS12_02884 3138638 3139090 - 50S ribosomal protein L9 Binds to the 23S rRNA%3B Belongs to the ribosomal protein L9P family gene gene2883 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02884 VSVS12_02885 VSVS12_02885 VSVS12_02885 3139124 3139351 - 30S ribosomal protein S18 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA%2C where it helps stabilize the platform of the 30S subunit%3B Belongs to the ribosomal protein S18P family gene gene2884 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02885 VSVS12_02886 VSVS12_02886 VSVS12_02886 3139368 3139670 - Primosomal replication protein Binds single-stranded DNA at the primosome assembly site (PAS)%3B Belongs to the PriB family%3B Contains 1 SSB domain gene gene2885 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02886 VSVS12_02887 VSVS12_02887 VSVS12_02887 3139679 3140059 - 30S ribosomal protein S6 Binds together with S18 to 16S ribosomal RNA%3B Belongs to the ribosomal protein S6P family gene gene2886 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02887 VSVS12_02888 VSVS12_02888 VSVS12_02888 3140282 3140767 - Ferroxidase Iron-storage protein%2C whose ferroxidase center binds Fe(2+) ions%2C oxidizes them by dioxygen to Fe(3+)%2C and participates in the subsequent Fe(3+) oxide mineral core formation within the central cavity of the protein complex%3B Belongs to the bacterioferritin family%3B Contains 1 ferritin-like diiron domain%3B KEGG: xfa:XF0395 bacterioferritin gene gene2887 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02888 VSVS12_02889 VSVS12_02889 VSVS12_02889 3140839 3141027 - Bacterioferritin-associated ferredoxin Seems to associate with BF%3B could be a general redox and/or regulatory component participating in the iron storage mobilization functions of BFR. Could participate in the release or the delivery of iron from/to bacterioferritin (or other iron complexes) (By similarity) gene gene2888 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02889 VSVS12_02890 VSVS12_02890 VSVS12_02890 3141338 3142522 - Elongation factor Tu-A This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis%3B Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily%3B Contains 1 tr-type G (guanine nucleotide-binding) domain gene gene2889 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02890 VSVS12_02891 VSVS12_02891 VSVS12_02891 3142678 3144777 - Elongation factor G Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step%2C the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites%2C respectively. Catalyzes the coordinated movement of the two tRNA molecules%2C the mRNA and conformational changes in the ribosome%3B Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily%3B Contains 1 tr-type G (guanine nucleotide-binding) domain gene gene2890 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02891 VSVS12_02892 VSVS12_02892 VSVS12_02892 3144916 3145386 - 30S ribosomal protein S7 One of the primary rRNA binding proteins%2C it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center%2C probably blocks exit of the E-site tRNA%3B Belongs to the ribosomal protein S7P family gene gene2891 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02892 VSVS12_02893 VSVS12_02893 VSVS12_02893 3145482 3145856 - 30S ribosomal protein S12%2C chloroplastic With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits (By similarity)%3B Belongs to the ribosomal protein S12P family gene gene2892 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02893 VSVS12_02894 VSVS12_02894 VSVS12_02894 3146050 3146325 - hypothetical protein gene gene2893 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02894 VSVS12_02895 VSVS12_02895 VSVS12_02895 3146335 3146691 - Protein TusC like protein Could be part of a sulfur-relay system%3B Belongs to the DsrF/TusC family gene gene2894 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02895 VSVS12_02896 VSVS12_02896 tusD tusD 3146688 3147080 - Sulfurtransferase TusD Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE%3B Belongs to the DsrE/TusD family%3B KEGG: smaf:D781_4281 tRNA 2-thiouridine synthesizing protein D%3B Sulfurtransferases gene gene2895 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02896 VSVS12_02897 VSVS12_02897 VSVS12_02897 3147071 3147799 - uncharacterized protein To H. influenzae HI_0575 gene gene2896 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02897 VSVS12_02898 VSVS12_02898 fkpA fkpA 3148062 3148862 - Peptidylprolyl isomerase PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. FkpA probably acts in the folding of extracytoplasmic proteins. Belongs to the FKBP-type PPIase family%3B Contains 1 PPIase FKBP-type domain%3B KEGG: pfq:QQ39_01560 FKBP-type peptidyl-prolyl cis-trans isomerase FkpA gene gene2897 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02898 VSVS12_02899 VSVS12_02899 VSVS12_02899 3148995 3149972 + putative WD repeat-containing protein Contains 16 WD repeats gene gene2898 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02899 VSVS12_02900 VSVS12_02900 VSVS12_02900 3149977 3150204 + Protein SlyX like protein Belongs to the SlyX family gene gene2899 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02900 VSVS12_02901 VSVS12_02901 VSVS12_02901 3150263 3150448 - uncharacterized protein gene gene2900 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02901 VSVS12_02902 VSVS12_02902 hflC hflC 3150609 3151592 - Protein HflC HflC and HflK could regulate a protease%3B Belongs to the band 7/mec-2 family. HflC subfamily%3B KEGG: pfq:QQ39_02145 membrane protease subunit HflC%3B Acting on peptide bonds (peptidases) gene gene2901 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02902 VSVS12_02903 VSVS12_02903 VSVS12_02903 3151595 3152791 - Protein HflK HflC and HflK could encode or regulate a protease%3B Belongs to the band 7/mec-2 family. HflK subfamily%3B KEGG: vch:VC0349 membrane protease subunit HflK%3B Acting on peptide bonds (peptidases) gene gene2902 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02903 VSVS12_02904 VSVS12_02904 VSVS12_02904 3152837 3154126 - GTPase HflX GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis. In vitro%2C also exhibits ATPase activity%3B Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family%3B Contains 1 Hflx-type G (guanine nucleotide-binding) domain gene gene2903 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02904 VSVS12_02905 VSVS12_02905 VSVS12_02905 3154167 3154427 - RNA-binding protein Hfq RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress%2C environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs%3B Belongs to the Hfq family gene gene2904 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02905 VSVS12_02906 VSVS12_02906 miaA miaA 3154611 3155558 - tRNA dimethylallyltransferase Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine%2C leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)%3B Belongs to the IPP transferase family%3B KEGG: yro:CH64_3005 tRNA dimethylallyltransferase gene gene2905 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02906 VSVS12_02907 VSVS12_02907 VSVS12_02907 3155555 3157633 - DNA mismatch repair protein MutL This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker'%2C a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex%3B Belongs to the DNA mismatch repair MutL/HexB family gene gene2906 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02907 VSVS12_02908 VSVS12_02908 amiA amiA 3157646 3159361 - N-acetylmuramoyl-L-alanine amidase Cell-wall hydrolase involved in septum cleavage during cell division%3B Belongs to the N-acetylmuramoyl-L-alanine amidase 3 family%3B KEGG: vcy:IX92_13820 N-acetylmuramoyl-L-alanine amidase gene gene2907 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02908 VSVS12_02909 VSVS12_02909 VSVS12_02909 3159358 3159822 - tRNA threonylcarbamoyladenosine biosynthesis protein TsaE Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37%2C together with TsaD and TsaB. TsaE seems to play an indirect role in the t(6)A biosynthesis pathway%2C possibly in regulating the core enzymatic function of TsaD (By similarity)%3B Belongs to the TsaE family gene gene2908 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02909 VSVS12_02910 VSVS12_02910 queG queG 3160011 3161132 + Epoxyqueuosine reductase Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q)%2C which is a hypermodified base found in the wobble positions of tRNA(Asp)%2C tRNA(Asn)%2C tRNA(His) and tRNA(Tyr)%3B Belongs to the QueG family%3B Contains 1 4Fe-4S ferredoxin-type domain%3B KEGG: kmi:VW41_02060 epoxyqueuosine reductase gene gene2909 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02910 VSVS12_02911 VSVS12_02911 VSVS12_02911 3161721 3161796 - tRNA-Gly tRNA gene2910 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02911 VSVS12_02912 VSVS12_02912 VSVS12_02912 3161829 3161905 - tRNA-Met tRNA gene2911 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02912 VSVS12_02913 VSVS12_02913 VSVS12_02913 3161958 3162033 - tRNA-Gly tRNA gene2912 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02913 VSVS12_02914 VSVS12_02914 VSVS12_02914 3162067 3162143 - tRNA-Met tRNA gene2913 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02914 VSVS12_02915 VSVS12_02915 VSVS12_02915 3162179 3162254 - tRNA-Gly tRNA gene2914 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02915 VSVS12_02916 VSVS12_02916 VSVS12_02916 3162287 3162363 - tRNA-Met tRNA gene2915 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02916 VSVS12_02917 VSVS12_02917 VSVS12_02917 3162417 3162492 - tRNA-Gly tRNA gene2916 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02917 VSVS12_02918 VSVS12_02918 VSVS12_02918 3162525 3162601 - tRNA-Met tRNA gene2917 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02918 VSVS12_02919 VSVS12_02919 VSVS12_02919 3162637 3162712 - tRNA-Gly tRNA gene2918 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02919 VSVS12_02920 VSVS12_02920 VSVS12_02920 3162835 3162911 - tRNA-Met tRNA gene2919 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02920 VSVS12_02921 VSVS12_02921 VSVS12_02921 3162980 3163055 - tRNA-Gly tRNA gene2920 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02921 VSVS12_02922 VSVS12_02922 VSVS12_02922 3163423 3164142 + hypothetical protein gene gene2921 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02922 VSVS12_02923 VSVS12_02923 rex2 rex2 3164224 3164769 - Oligoribonuclease 3'-to-5' exoribonuclease specific for small oligoribonucleotides%3B Belongs to the oligoribonuclease family%3B Contains 1 exonuclease domain%3B KEGG: vch:VC0341 oligoribonuclease%3B Acting on ester bonds gene gene2922 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02923 VSVS12_02924 VSVS12_02924 rsgA rsgA 3164881 3165936 + Putative ribosome bioproteinis GTPase RsgA May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover%3B Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily%3B Contains 1 CP-type G (guanine nucleotide-binding) domain%3B KEGG: vsp:VS_0254 ribosome biogenesis GTPase%3B In phosphorus-containing anhydrides gene gene2923 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02924 VSVS12_02925 VSVS12_02925 pisD pisD 3166046 3166912 + Phosphatidylserine decarboxylase Belongs to the phosphatidylserine decarboxylase family. Type 1 subfamily%3B KEGG: pmr:PMI3355 phosphatidylserine decarboxylase gene gene2924 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02925 VSVS12_02926 VSVS12_02926 VSVS12_02926 3167086 3168489 + putative transporter Belongs to the CitM (TC 2. A. 11) transporter family%3B Contains 1 SPX domain gene gene2925 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02926 VSVS12_02927 VSVS12_02927 VSVS12_02927 3168619 3169506 + hypothetical protein gene gene2926 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02927 VSVS12_02928 VSVS12_02928 gpmI gpmI 3169781 3171313 + Phosphoglycerate mutase (2%2C3-diphosphoglycerate-independent) Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate%3B Belongs to the BPG-independent phosphoglycerate mutase family%3B KEGG: vch:VC0336 2%2C3-bisphosphoglycerate-independent phosphoglycerate mutase gene gene2927 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02928 VSVS12_02929 VSVS12_02929 VSVS12_02929 3171476 3172618 + Murein hydrolase activator EnvC Activator of the cell wall hydrolases AmiA and AmiB. Required for septal murein cleavage and daughter cell separation during cell division. In vitro%2C exhibits weak endoproteolytic activity on beta-casein%3B Belongs to the peptidase M23B family gene gene2928 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02929 VSVS12_02930 VSVS12_02930 VSVS12_02930 3172708 3173667 - hypothetical protein gene gene2929 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02930 VSVS12_02931 VSVS12_02931 VSVS12_02931 3173782 3174420 - hypothetical protein gene gene2930 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02931 VSVS12_02932 VSVS12_02932 hemE hemE 3174517 3175584 - Uroporphyrinogen decarboxylase Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III%3B Belongs to the uroporphyrinogen decarboxylase family%3B KEGG: eco:b3997 uroporphyrinogen decarboxylase gene gene2931 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02932 VSVS12_02933 VSVS12_02933 nudC nudC 3175834 3176628 - NAD(+) diphosphatase Belongs to the Nudix hydrolase family. NudC subfamily%3B Contains 1 nudix hydrolase domain%3B KEGG: vcy:IX92_13940 NAD+ diphosphatase gene gene2932 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02933 VSVS12_02934 VSVS12_02934 VSVS12_02934 3176814 3177302 + hypothetical protein gene gene2933 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02934 VSVS12_02935 VSVS12_02935 rpoC rpoC 3177835 3182037 - DNA-directed RNA polymerase DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates%3B Belongs to the RNA polymerase beta' chain family%3B KEGG: eco:b3988 DNA-directed RNA polymerase subunit beta' gene gene2934 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02935 VSVS12_02936 VSVS12_02936 rpoB rpoB 3182143 3186171 - DNA-directed RNA polymerase DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates%3B Belongs to the RNA polymerase beta chain family%3B KEGG: eco:b3987 DNA-directed RNA polymerase subunit beta gene gene2935 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02936 VSVS12_02937 VSVS12_02937 VSVS12_02937 3186400 3186765 - 50S ribosomal protein L7/L12 Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation%3B Belongs to the ribosomal protein L7/L12P family gene gene2936 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02937 VSVS12_02938 VSVS12_02938 VSVS12_02938 3186825 3187319 - 50S ribosomal protein L10 Forms part of the ribosomal stalk%2C playing a central role in the interaction of the ribosome with GTP-bound translation factors%3B Belongs to the ribosomal protein L10P family gene gene2937 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02938 VSVS12_02939 VSVS12_02939 VSVS12_02939 3187623 3188324 - 50S ribosomal protein L1 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome%2C and is involved in E site tRNA release%3B Protein L1 is also a translational repressor protein%2C it controls the translation of the L11 operon by binding to its mRNA%3B Belongs to the ribosomal protein L1P family gene gene2938 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02939 VSVS12_02940 VSVS12_02940 VSVS12_02940 3188329 3188757 - 50S ribosomal protein L11 Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors%3B Belongs to the ribosomal protein L11P family gene gene2939 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02940 VSVS12_02941 VSVS12_02941 VSVS12_02941 3188902 3189450 - Transcription termination/antitermination protein Participates in transcription elongation%2C termination and antitermination. In the absence of Rho%2C increases the rate of transcription elongation by the RNA polymerase (RNAP)%2C probably by partially suppressing pausing. In the presence of Rho%2C modulates most Rho-dependent termination events by interacting with the RNAP to render the complex more susceptible to the termination activity of Rho. May be required to overcome a kinetic limitation of Rho to function at certain terminators. Also involved in ribosomal RNA transcriptional antitermination%3B Belongs to the NusG family%3B Contains 1 KOW domain gene gene2940 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02941 VSVS12_02942 VSVS12_02942 VSVS12_02942 3189464 3189844 - Protein translocase subunit SecE Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation%3B Belongs to the SecE/SEC61-gamma family gene gene2941 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02942 VSVS12_02943 VSVS12_02943 VSVS12_02943 3190119 3191303 - Elongation factor Tu-A This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis%3B Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily%3B Contains 1 tr-type G (guanine nucleotide-binding) domain gene gene2942 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02943 VSVS12_02944 VSVS12_02944 VSVS12_02944 3191406 3191481 - tRNA-Thr tRNA gene2943 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02944 VSVS12_02945 VSVS12_02945 VSVS12_02945 3191494 3191568 - tRNA-Gly tRNA gene2944 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02945 VSVS12_02946 VSVS12_02946 VSVS12_02946 3191603 3191687 - tRNA-Tyr tRNA gene2945 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02946 VSVS12_02947 VSVS12_02947 VSVS12_02947 3191741 3191816 - tRNA-Thr tRNA gene2946 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02947 VSVS12_02948 VSVS12_02948 coaA coaA 3192022 3192951 + Pantothenate kinase Belongs to the prokaryotic pantothenate kinase family%3B KEGG: eco:b3974 type I pantothenate kinase gene gene2947 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02948 VSVS12_02949 VSVS12_02949 VSVS12_02949 3193087 3193512 - hypothetical protein gene gene2948 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02949 VSVS12_02950 VSVS12_02950 hpaF hpaF 3193633 3193980 - 5-carboxymethyl-2-hydroxymuconate Delta-isomerase KEGG: vfi:VF_0207 5-carboxymethyl-2-hydroxymuconate isomerase gene gene2949 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02950 VSVS12_02951 VSVS12_02951 tpiA tpiA 3194251 3195021 + Triose-phosphate isomerase Belongs to the triosephosphate isomerase family%3B KEGG: hhs:HHS_01030 triosephosphate isomerase (TIM) gene gene2950 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02951 VSVS12_02952 VSVS12_02952 VSVS12_02952 3195165 3196556 + putative transporter Belongs to the multi antimicrobial extrusion (MATE) (TC 2. A. 66. 1) family gene gene2951 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02952 VSVS12_02953 VSVS12_02953 VSVS12_02953 3196664 3197176 - Regulator of ribonuclease activity Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome%3B Belongs to the RraA family gene gene2952 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02953 VSVS12_02954 VSVS12_02954 menA menA 3197252 3198169 - 1%2C4-dihydroxy-2-naphthoate octaprenyltransferase Conversion of 1%2C4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK). Attaches octaprenylpyrophosphate%2C a membrane-bound 40-carbon side chain to DHNA. The conversion of DHNA to DMK proceeds in three stages: the removal of the carboxyl group of DHNA as CO(2)%2C the attachment of the isoprenoid side chain%2C and a quinol-to-quinone oxidation%2C which is thought to be spontaneous%3B Belongs to the MenA family. Type 1 subfamily%3B KEGG: vch:VC2673 1%2C4-dihydroxy-2-naphthoate octaprenyltransferase%3B 1%2C4-dihydroxy-2-naphthoate polyprenyltransferase gene gene2953 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02954 VSVS12_02955 VSVS12_02955 VSVS12_02955 3198276 3198842 - Elongation factor Involved in peptide bond synthesis. Alleviates ribosome stalling that occurs when 3 or more consecutive Pro residues or the sequence PPG is present in a protein%2C possibly by augmenting the peptidyl transferase activity of the ribosome. Modification of Lys-34 is required for alleviation%3B Belongs to the elongation factor P family gene gene2954 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02955 VSVS12_02956 VSVS12_02956 kamA kamA 3198876 3199898 + Lysine 2%2C3-aminomutase With EpmA is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P) on 'Lys-34'. EpmB appears to act before EpmA. Displays lysine 2%2C3-aminomutase activity%2C producing (R)-beta-lysine from (S)-alpha-lysine (L-lysine) (By similarity)%3B Belongs to the radical SAM superfamily. KamA family%3B KEGG: gur:Gura_2149 lysine 2%2C3-aminomutase gene gene2955 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02956 VSVS12_02957 VSVS12_02957 VSVS12_02957 3199977 3200468 + hypothetical protein gene gene2956 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02957 VSVS12_02958 VSVS12_02958 VSVS12_02958 3200559 3201068 + Protein MgtC Virulence factor required for growth in low Mg(2+) medium and for intramacrophage survival. May be involved in regulating membrane potential by activating Na(+)/K(+)-ATPase (By similarity)%3B Belongs to the MgtC/SapB family gene gene2957 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02958 VSVS12_02959 VSVS12_02959 pfkA pfkA 3201159 3202121 - 6-phosphofructokinase Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1%2C6-bisphosphate by ATP%2C the first committing step of glycolysis%3B Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Prokaryotic clade 'B1' sub-subfamily%3B KEGG: eco:b3916 6-phosphofructokinase 1 gene gene2958 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02959 VSVS12_02960 VSVS12_02960 VSVS12_02960 3202394 3203302 - Cation-efflux pump FieF Cation-efflux transporter that may have a role in detoxification%3B Belongs to the cation diffusion facilitator (CDF) transporter (TC 2. A. 4) family. FieF subfamily gene gene2959 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02960 VSVS12_02961 VSVS12_02961 VSVS12_02961 3203486 3203974 - Periplasmic protein CpxP Aids in combating extracytoplasmic protein-mediated toxicity%3B To E. coli spy gene gene2960 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02961 VSVS12_02962 VSVS12_02962 VSVS12_02962 3204155 3204841 + Response regulator SaeR Member of the two-component regulatory system SaeR/SaeS involved in the regulation of staphylococcal virulence factors in a strain-dependent fashion. Probably functions as a transcriptional regulator via a specific DNA-binding domain%2C recognizing motifs near the promoter sequences of target genes (By similarity)%3B Contains 1 OmpR/PhoB-type DNA-binding domain%3B Contains 1 response regulatory domain gene gene2961 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02962 VSVS12_02963 VSVS12_02963 VSVS12_02963 3204841 3206223 + Histidine kinase This protein is involved in several diverse cellular processes%2C such as the functioning of acetohydroxyacid synthetase I%2C in the biosynthesis of isoleucine and valine%2C the TraJ protein activation activity for tra gene expression in F plasmid%2C and the synthesis%2C translocation%2C or stability of cell envelope proteins. Activates CpxR by phosphorylation (By similarity)%3B Contains 1 HAMP domain%3B Contains 1 histidine kinase domain%3B KEGG: vvu:VV1_1253 two-component system%2C OmpR family%2C sensor histidine kinase CpxA gene gene2962 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02963 VSVS12_02964 VSVS12_02964 trmL trmL 3206337 3206816 + tRNA (cytidine(34)-2'-O)-methyltransferase Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide%3B Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily%3B KEGG: vch:VC2695 tRNA (cytidine/uridine-2'-O-)-methyltransferase gene gene2963 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02964 VSVS12_02965 VSVS12_02965 VSVS12_02965 3206903 3207433 - UPF0716 protein YtzA Belongs to the UPF0716 (FxsA) family gene gene2964 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02965 VSVS12_02966 VSVS12_02966 aspA aspA 3207857 3209305 + Aspartate ammonia-lyase Belongs to the class-II fumarase/aspartase family. Aspartase subfamily%3B KEGG: vpa:VP2863 aspartate ammonia-lyase gene gene2965 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02966 VSVS12_02967 VSVS12_02967 VSVS12_02967 3209534 3210841 + Anaerobic C4-dicarboxylate transporter DcuA Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane%3B Belongs to the DcuA/DcuB transporter (TC 2. A. 13. 1) family gene gene2966 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02967 VSVS12_02968 VSVS12_02968 dsbD dsbD 3211079 3212884 + Protein-disulfide reductase Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps%3B Belongs to the thioredoxin family. DsbD subfamily%3B Contains 1 thioredoxin domain%3B KEGG: vvu:VV1_1247 thiol:disulfide interchange protein DsbD gene gene2967 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02968 VSVS12_02969 VSVS12_02969 VSVS12_02969 3213043 3213678 + Glycerol metabolism activator Positive activator for glycerol metabolism. Contains 1 HTH luxR-type DNA-binding domain%3B Contains 1 response regulatory domain gene gene2968 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02969 VSVS12_02970 VSVS12_02970 VSVS12_02970 3213834 3214460 + UPF0056 membrane protein YhcE Belongs to the UPF0056 (MarC) family gene gene2969 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02970 VSVS12_02971 VSVS12_02971 VSVS12_02971 3214678 3214941 + hypothetical protein gene gene2970 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02971 VSVS12_02972 VSVS12_02972 VSVS12_02972 3214954 3216681 + putative symporter YwcA Belongs to the sodium:solute symporter (SSF) (TC 2. A. 21) family gene gene2971 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02972 VSVS12_02973 VSVS12_02973 VSVS12_02973 3216833 3217321 + hypothetical protein gene gene2972 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02973 VSVS12_02974 VSVS12_02974 VSVS12_02974 3217348 3220779 - Sensory/regulatory protein RpfC Member of the two-component regulatory system RpfG/RpfC%2C which is required for full virulence and for formation and dispersal of biofilms. Involved in sensing and responding to the diffusible signaling factor (DSF)%2C which is essential for cell- cell signaling. RpfC is probably a sensor of environmental signals%2C including DSF%2C which is autophosphorylated at a histidine residue in response to the signal. Then%2C probably activates RpfG via a four-step phosphorelay. May also negatively regulate the production of DSF%2C independently of RpfG%3B Contains 1 histidine kinase domain%3B Contains 1 HPt domain%3B Contains 1 response regulatory domain%3B KEGG: vfi:VF_2379 null%3B Phosphotransferases with a nitrogenous group as acceptor gene gene2973 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02974 VSVS12_02975 VSVS12_02975 VSVS12_02975 3220874 3222064 - putative 3-phenylpropionic acid transporter Probable permease involved in the uptake of 3- phenylpropionic acid%3B Belongs to the LacY/RafB permease family. HcaT subfamily gene gene2974 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02975 VSVS12_02976 VSVS12_02976 VSVS12_02976 3222272 3224098 + hypothetical protein gene gene2975 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02976 VSVS12_02977 VSVS12_02977 VSVS12_02977 3224109 3224741 + DNA-directed DNA polymerase KEGG: vpa:VP2877 DNA polymerase III subunit epsilon gene gene2976 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02977 VSVS12_02978 VSVS12_02978 acsS acsS 3224975 3226927 + Acetate--CoA ligase Catalyzes the conversion of acetate into acetyl-CoA (AcCoA)%2C an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction%2C AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction%2C it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA%2C forming the product AcCoA%3B Belongs to the ATP-dependent AMP-binding enzyme family%3B KEGG: vch:VC0298 acetyl-CoA synthetase gene gene2977 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02978 VSVS12_02979 VSVS12_02979 aroQ aroQ 3227234 3227683 + 3-dehydroquinate dehydratase Catalyzes a trans-dehydration via an enolate intermediate%3B Belongs to the type-II 3-dehydroquinase family%3B KEGG: vch:VC0297 3-dehydroquinate dehydratase II gene gene2978 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02979 VSVS12_02980 VSVS12_02980 VSVS12_02980 3227743 3228204 + Biotin carboxyl carrier protein of acetyl-CoA carboxylase This protein is a component of the acetyl coenzyme A carboxylase comple%3B first%2C biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA%3B Contains 1 biotinyl-binding domain gene gene2979 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02980 VSVS12_02981 VSVS12_02981 accC accC 3228219 3229562 + Acetyl-CoA carboxylase This protein is a component of the acetyl coenzyme A carboxylase comple%3B first%2C biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA%3B Contains 1 ATP-grasp domain%3B Contains 1 biotin carboxylation domain%3B KEGG: eco:b3256 acetyl-CoA carboxylase%2C biotin carboxylase subunit gene gene2980 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02981 VSVS12_02982 VSVS12_02982 prmA prmA 3229669 3230556 + Ribosomal protein L11 methyltransferase Methylates ribosomal protein L11%3B Belongs to the methyltransferase superfamily. PrmA family%3B KEGG: vch:VC0293 ribosomal protein L11 methyltransferase%3B Methyltransferases gene gene2981 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02982 VSVS12_02983 VSVS12_02983 dusB dusB 3230744 3231664 + tRNA-dihydrouridine synthase Catalyzes the synthesis of 5%2C6-dihydrouridine (D)%2C a modified base found in the D-loop of most tRNAs%2C via the reduction of the C5-C6 double bond in target uridines%3B Belongs to the Dus family. DusB subfamily%3B KEGG: eco:b3260 tRNA-dihydrouridine synthase B%3B Oxidoreductases gene gene2982 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02983 VSVS12_02984 VSVS12_02984 VSVS12_02984 3231688 3231984 + DNA-binding protein Fis Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters%3B Belongs to the transcriptional regulatory Fis family gene gene2983 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02984 VSVS12_02985 VSVS12_02985 VSVS12_02985 3232230 3233219 + Diguanylate cyclase Contains 1 EAL domain%3B Contains 1 GGDEF domain%3B Contains 1 MHYT domain%3B Contains 1 PAS (PER-ARNT-SIM) domain%3B KEGG: csq:CSCA_1240 two-component system%2C cell cycle response regulator gene gene2984 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02985 VSVS12_02986 VSVS12_02986 VSVS12_02986 3233216 3233656 - HTH-type transcriptional regulator ZntR Zinc-responsive transcriptional regulator of zntA%3B Contains 1 HTH merR-type DNA-binding domain gene gene2985 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02986 VSVS12_02987 VSVS12_02987 purH purH 3233915 3235504 + Phosphoribosylaminoimidazolecarboxamide formyltransferase Belongs to the PurH family%3B KEGG: pfq:QQ39_15830 phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase gene gene2986 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02987 VSVS12_02988 VSVS12_02988 purD purD 3235788 3237077 + Phosphoribosylamine--glycine ligase Belongs to the GARS family%3B Contains 1 ATP-grasp domain%3B KEGG: xal:XALc_0306 phosphoribosylamine--glycine ligase gene gene2987 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02988 VSVS12_02989 VSVS12_02989 VSVS12_02989 3237141 3237725 - hypothetical protein gene gene2988 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02989 VSVS12_02990 VSVS12_02990 VSVS12_02990 3237886 3238158 - DNA-binding protein HU-1 Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it%2C and thus to prevent its denaturation under extreme environmental conditions%3B Belongs to the bacterial histone-like protein family gene gene2989 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02990 VSVS12_02991 VSVS12_02991 VSVS12_02991 3238511 3239611 + UPF0053 protein Belongs to the UPF0053 family%3B Contains 2 CBS domains%3B Contains 1 DUF21 domain gene gene2990 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02991 VSVS12_02992 VSVS12_02992 VSVS12_02992 3239670 3240257 - uncharacterized protein To H. influenzae HI_0431 gene gene2991 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02992 VSVS12_02993 VSVS12_02993 VSVS12_02993 3240329 3241255 + putative 2-ketogluconate reductase Catalyzes the NADPH-dependent reduction of 2%2C5-diketo-D- gluconate (25DKG) to 5-keto-D-gluconate (5KDG)%2C 2-keto-D-gluconate (2KDG) to D-gluconate%2C and 2-keto-L-gulonate (2KLG) to L-idonate (IA)%3B Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family%3B KEGG: pen:PSEEN4033 null%3B With NAD(+) or NADP(+) as acceptor gene gene2992 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02993 VSVS12_02994 VSVS12_02994 VSVS12_02994 3241255 3241587 + uncharacterized protein gene gene2993 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02994 VSVS12_02995 VSVS12_02995 VSVS12_02995 3242116 3242192 - tRNA-Asp tRNA gene2994 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02995 VSVS12_02996 VSVS12_02996 VSVS12_02996 3242263 3242378 - 5S ribosomal RNA rRNA gene2995 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02996 VSVS12_02997 VSVS12_02997 VSVS12_02997 3242469 3245362 - 23S ribosomal RNA rRNA gene2996 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02997 VSVS12_02998 VSVS12_02998 VSVS12_02998 3245656 3245731 - tRNA-Ala tRNA gene2997 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02998 VSVS12_02999 VSVS12_02999 VSVS12_02999 3245774 3245850 - tRNA-Ile tRNA gene2998 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_02999 VSVS12_03000 VSVS12_03000 VSVS12_03000 3245917 3247463 - 16S ribosomal RNA rRNA gene2999 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03000 VSVS12_03001 VSVS12_03001 VSVS12_03001 3247853 3247968 - 5S ribosomal RNA rRNA gene3000 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03001 VSVS12_03002 VSVS12_03002 VSVS12_03002 3248061 3250954 - 23S ribosomal RNA rRNA gene3001 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03002 VSVS12_03003 VSVS12_03003 VSVS12_03003 3251297 3251372 - tRNA-Val tRNA gene3002 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03003 VSVS12_03004 VSVS12_03004 VSVS12_03004 3251406 3251481 - tRNA-Lys tRNA gene3003 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03004 VSVS12_03005 VSVS12_03005 VSVS12_03005 3251486 3251561 - tRNA-Glu tRNA gene3004 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03005 VSVS12_03006 VSVS12_03006 VSVS12_03006 3251655 3253201 - 16S ribosomal RNA rRNA gene3005 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03006 VSVS12_03007 VSVS12_03007 VSVS12_03007 3253591 3253706 - 5S ribosomal RNA rRNA gene3006 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03007 VSVS12_03008 VSVS12_03008 VSVS12_03008 3253797 3256690 - 23S ribosomal RNA rRNA gene3007 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03008 VSVS12_03009 VSVS12_03009 VSVS12_03009 3256987 3258533 - 16S ribosomal RNA rRNA gene3008 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03009 VSVS12_03010 VSVS12_03010 VSVS12_03010 3259166 3259615 + Cleavage stimulation factor subunit One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs. This subunit is directly involved in the binding to pre-mRNAs (By similarity)%3B Contains 1 RRM (RNA recognition motif) domain gene gene3009 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03010 VSVS12_03011 VSVS12_03011 murI murI 3259581 3260372 - Glutamate racemase Provides the (R)-glutamate required for cell wall biosynthesis%3B Belongs to the aspartate/glutamate racemases family%3B KEGG: oac:Oscil6304_4153 glutamate racemase gene gene3010 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03011 VSVS12_03012 VSVS12_03012 VSVS12_03012 3260404 3261087 - hypothetical protein gene gene3011 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03012 VSVS12_03013 VSVS12_03013 VSVS12_03013 3261140 3262960 - Vitamin B12 transporter BtuB Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB%3B Belongs to the TonB-dependent receptor family. BtuB (TC 1. B. 14. 3. 1) subfamily gene gene3012 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03013 VSVS12_03014 VSVS12_03014 trmA trmA 3263400 3264509 + tRNA (uracil(54)-C(5))-methyltransferase Dual-specificity methyltransferase that catalyzes the formation of 5-methyluridine at position 54 (m5U54) in all tRNAs%2C and that of position 341 (m5U341) in tmRNA (transfer-mRNA)%3B Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. TrmA subfamily%3B KEGG: vch:VC0154 tRNA (uracil-5-)-methyltransferase gene gene3013 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03014 VSVS12_03015 VSVS12_03015 VSVS12_03015 3264572 3264958 - Inner membrane protein gene gene3014 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03015 VSVS12_03016 VSVS12_03016 VSVS12_03016 3264958 3265407 - HTH-type transcriptional repressor FabR Represses the transcription of fabB%2C involved in unsaturated fatty acid (UFA) biosynthesis. By controlling UFA production%2C FabR directly influences the physical properties of the membrane bilayer%3B Contains 1 HTH tetR-type DNA-binding domain gene gene3015 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03016 VSVS12_03017 VSVS12_03017 VSVS12_03017 3265877 3265993 + NAD(P)(+) transhydrogenase (Si-specific) Conversion of NADPH%2C generated by peripheral catabolic pathways%2C to NADH%2C which can enter the respiratory chain for energy generation%3B Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family%3B KEGG: vcy:IX92_00925 NAD(P) transhydrogenase gene gene3016 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03017 VSVS12_03018 VSVS12_03018 VSVS12_03018 3266253 3266486 + NAD(P)(+) transhydrogenase (Si-specific) Conversion of NADPH%2C generated by peripheral catabolic pathways%2C to NADH%2C which can enter the respiratory chain for energy generation%3B Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family%3B KEGG: vha:VIBHAR_00265 NAD(P) transhydrogenase gene gene3017 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03018 VSVS12_03019 VSVS12_03019 yhhY yhhY 1188 1679 + putative N-acetyltransferase YhhY Belongs to the acetyltransferase family%3B Contains 1 N-acetyltransferase domain%3B KEGG: vcy:IX92_17440 putative acetyltransferase%3B Transferring groups other than amino-acyl groups gene gene3018 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03019 VSVS12_03020 VSVS12_03020 VSVS12_03020 2284 3021 + Cyclic di-GMP binding protein May act as a flagellar brake%2C regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Increasing levels of c-di-GMP lead to decreased motility (Potential). Binds bis-(3'-5') cyclic diguanylic acid (c- di-GMP) with a dissociation constant of 170 nM in the presence of 10 mM KCl and with 100 nM in its absence. Binds 1 to 2 c-di-GMP per subunit. Only 1 c-di-GMP is seen in the wild-type crystal%2C while 2 are seen in the mutant. Depending on the concentration of K(+) stoichiometries of 1:1%2C 1. 43:1 and 2:1 are determined by isothermal titration calorimetry%3B Belongs to the YcgR family%3B Contains 1 PilZ domain gene gene3019 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03020 VSVS12_03021 VSVS12_03021 VSVS12_03021 3169 4053 + hypothetical protein gene gene3020 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03021 VSVS12_03022 VSVS12_03022 VSVS12_03022 4298 6154 + putative ABC transporter ATP-binding protein Belongs to the ABC transporter superfamily%3B Contains 1 ABC transmembrane type-1 domain%3B Contains 1 ABC transporter domain gene gene3021 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03022 VSVS12_03023 VSVS12_03023 VSVS12_03023 6349 7053 + hypothetical protein gene gene3022 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03023 VSVS12_03024 VSVS12_03024 VSVS12_03024 7126 7593 - Leucine-responsive regulatory protein Mediates a global response to leucine. Exogenous leucine affects the expression of a number of different operon%3B lrp mediates this effect for at least some of these operons. For example it is regulator of the branched-chain amino acid transport genes (By similarity)%3B Contains 1 HTH asnC-type DNA-binding domain gene gene3023 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03024 VSVS12_03025 VSVS12_03025 VSVS12_03025 7691 7918 - hypothetical protein gene gene3024 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03025 VSVS12_03026 VSVS12_03026 VSVS12_03026 8096 9586 - Sodium/proline symporter Catalyzes the sodium-dependent uptake of extracellular L-proline%3B Belongs to the sodium:solute symporter (SSF) (TC 2. A. 21) family gene gene3025 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03026 VSVS12_03027 VSVS12_03027 VSVS12_03027 9681 10373 - hypothetical protein gene gene3026 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03027 VSVS12_03028 VSVS12_03028 putA putA 10388 13516 - Proline dehydrogenase Oxidizes proline to glutamate for use as a carbon and nitrogen source and also function as a transcriptional repressor of the put operon. In the N-terminal sectio%3B belongs to the proline dehydrogenase family%3B In the C-terminal sectio%3B belongs to the aldehyde dehydrogenase family%3B KEGG: vco:VC0395_0169 RHH-type transcriptional regulator%2C proline utilization regulon repressor / proline dehydrogenase / delta 1-pyrroline-5-carboxylate dehydrogenase gene gene3027 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03028 VSVS12_03029 VSVS12_03029 VSVS12_03029 13703 14524 - Thermoregulatory protein LcrF Transcriptional activator of the thermally regulated virulent yopE gene. LcrF activity could be modulated by the interaction with an inducer molecule serving as a temperature messenger. The availability of the messenger would in turn be controlled by a temperature-responsive process serving as a cellular thermometer. Contains 1 HTH araC/xylS-type DNA-binding domain gene gene3028 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03029 VSVS12_03030 VSVS12_03030 VSVS12_03030 14958 16058 + hypothetical protein gene gene3029 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03030 VSVS12_03031 VSVS12_03031 ppkA ppkA 16211 18037 + Non-specific serine/threonine protein kinase KEGG: tvi:Thivi_4543 serine/threonine-protein kinase PpkA gene gene3030 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03031 VSVS12_03032 VSVS12_03032 VSVS12_03032 18332 19051 + hypothetical protein gene gene3031 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03032 VSVS12_03033 VSVS12_03033 pdxH pdxH 19118 19636 - Pyridoxal 5'-phosphate synthase Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP)%3B Belongs to the pyridoxamine 5'-phosphate oxidase family%3B KEGG: eca:ECA1935 pyridoxamine 5'-phosphate oxidase gene gene3032 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03033 VSVS12_03034 VSVS12_03034 VSVS12_03034 19615 19752 - hypothetical protein gene gene3033 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03034 VSVS12_03035 VSVS12_03035 VSVS12_03035 19978 21411 + Leukotoxin secretion protein Involved in the transport of the Leukotoxin. Belongs to the membrane fusion protein (MFP) (TC 8. A. 1) family gene gene3034 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03035 VSVS12_03036 VSVS12_03036 VSVS12_03036 21526 22290 + hypothetical protein gene gene3035 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03036 VSVS12_03037 VSVS12_03037 wspR wspR 22296 24206 + Diguanylate cyclase KEGG: byi:BYI23_B000130 two-component system%2C chemotaxis family%2C response regulator WspR gene gene3036 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03037 VSVS12_03038 VSVS12_03038 VSVS12_03038 24227 26344 + Alpha-hemolysin translocation ATP-binding protein HlyB Part of the ABC transporter complex HlyBD involved in hemolysin export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)%3B Belongs to the ABC transporter superfamily. Protein-1 exporter (TC 3. A. 1. 109) family%3B Contains 1 ABC transmembrane type-1 domain%3B Contains 1 ABC transporter domain%3B Contains 1 peptidase C39 domain gene gene3037 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03038 VSVS12_03039 VSVS12_03039 VSVS12_03039 26579 27217 + UPF0319 protein Belongs to the UPF0319 family gene gene3038 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03039 VSVS12_03040 VSVS12_03040 rimL rimL 27294 27827 + Putative ribosomal-protein-alanine acetyltransferase This enzyme acetylates the N-terminal alanine of ribosomal protein S5%3B Belongs to the acetyltransferase family. RimJ subfamily%3B Contains 1 N-acetyltransferase domain%3B KEGG: wce:WS08_0663 ribosomal-protein-serine acetyltransferase%3B Transferring groups other than amino-acyl groups gene gene3039 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03040 VSVS12_03041 VSVS12_03041 VSVS12_03041 27971 28396 + hypothetical protein gene gene3040 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03041 VSVS12_03042 VSVS12_03042 VSVS12_03042 28393 28983 + Protein SCO1 like protein 1%2C mitochondrial Thought to play a role in cellular copper homeostasis%2C mitochondrial redox signaling or insertion of copper into the active site of COX. Plays an essential role in embryo development%3B Belongs to the SCO1/2 family%3B Contains 1 thioredoxin domain gene gene3041 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03042 VSVS12_03043 VSVS12_03043 VSVS12_03043 28996 29442 + hypothetical protein gene gene3042 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03043 VSVS12_03044 VSVS12_03044 VSVS12_03044 29563 30615 + Putative ribosome bioproteinis GTPase RsgA May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover%3B Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily%3B Contains 1 CP-type G (guanine nucleotide-binding) domain%3B KEGG: vsp:VS_II0177 ribosome biogenesis GTPase%3B In phosphorus-containing anhydrides gene gene3043 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03044 VSVS12_03045 VSVS12_03045 VSVS12_03045 30883 32106 + Serine/threonine transporter SstT Involved in the import of serine and threonine into the cell%2C with the concomitant import of sodium (symport system)%3B Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2. A. 23) family gene gene3044 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03045 VSVS12_03046 VSVS12_03046 VSVS12_03046 32297 33463 - uncharacterized protein To E. coli YbeT gene gene3045 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03046 VSVS12_03047 VSVS12_03047 nagB nagB 33972 34772 + Glucosamine-6-phosphate deaminase Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion%3B Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily%3B KEGG: hpr:PARA_00630 glucosamine-6-phosphate deaminase gene gene3046 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03047 VSVS12_03048 VSVS12_03048 VSVS12_03048 34832 35164 - Membrane protein GlpM Could play a role in alginate biosynthesis. Overexpression may be lethal. To E. coli YdgC gene gene3047 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03048 VSVS12_03049 VSVS12_03049 VSVS12_03049 35177 35533 - hypothetical protein gene gene3048 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03049 VSVS12_03050 VSVS12_03050 VSVS12_03050 35769 36095 + hypothetical protein gene gene3049 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03050 VSVS12_03051 VSVS12_03051 VSVS12_03051 36246 37010 - Ferredoxin--NADP(+) reductase Transports electrons between flavodoxin or ferredoxin and NADPH%3B Belongs to the ferredoxin--NADP reductase type 1 family%3B Contains 1 FAD-binding FR-type domain%3B KEGG: vvl:VV93_v1c43540 ferredoxin--NADP+ reductase gene gene3050 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03051 VSVS12_03052 VSVS12_03052 VSVS12_03052 37196 37414 + hypothetical protein gene gene3051 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03052 VSVS12_03053 VSVS12_03053 VSVS12_03053 37622 38920 + Prolyl aminopeptidase Higher activity toward long peptides. Acts on hydroxyproline beta-naphthylamide with almost as high an activity as on proline beta-naphthylamide. Belongs to the peptidase S33 family%3B KEGG: saz:Sama_2143 proline iminopeptidase gene gene3052 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03053 VSVS12_03054 VSVS12_03054 VSVS12_03054 38989 39402 + Peptidyl-tRNA hydrolase ArfB Rescues stalled ribosomes. Can hydrolyze peptidyl-tRNA on ribosomes stalled by both non-stop mRNAs and mRNAs that contain rare codon clusters. May function as a complementary rescue system when the stalled ribosome can not be rescued by the SsrA(tmRNA)- SmpB quality control system or the alternative ribosome-rescue factor A%3B Belongs to the prokaryotic/mitochondrial release factor family gene gene3053 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03054 VSVS12_03055 VSVS12_03055 VSVS12_03055 39523 43662 + hypothetical protein gene gene3054 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03055 VSVS12_03056 VSVS12_03056 VSVS12_03056 43729 44547 - hypothetical protein gene gene3055 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03056 VSVS12_03057 VSVS12_03057 VSVS12_03057 44670 45059 - putative HTH-type transcriptional regulator YkoM Contains 1 HTH marR-type DNA-binding domain gene gene3056 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03057 VSVS12_03058 VSVS12_03058 VSVS12_03058 45114 45743 - hypothetical protein gene gene3057 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03058 VSVS12_03059 VSVS12_03059 VSVS12_03059 45909 46340 + hypothetical protein gene gene3058 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03059 VSVS12_03060 VSVS12_03060 VSVS12_03060 46421 46876 + hypothetical protein gene gene3059 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03060 VSVS12_03061 VSVS12_03061 VSVS12_03061 46914 47540 - Demethylmenaquinone methyltransferase Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2)%3B Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family gene gene3060 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03061 VSVS12_03062 VSVS12_03062 VSVS12_03062 47865 48323 - UPF0178 protein Belongs to the UPF0178 family gene gene3061 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03062 VSVS12_03063 VSVS12_03063 VSVS12_03063 48751 50055 + C4-dicarboxylate transport protein Responsible for the transport of dicarboxylates such as succinate%2C fumarate%2C and malate from the periplasm across the membrane%3B Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2. A. 23) family gene gene3062 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03063 VSVS12_03064 VSVS12_03064 VSVS12_03064 50180 50608 - hypothetical protein gene gene3063 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03064 VSVS12_03065 VSVS12_03065 VSVS12_03065 50756 51880 - Glutamate carboxypeptidase KEGG: vpa:VPA1611 glutamate carboxypeptidase gene gene3064 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03065 VSVS12_03066 VSVS12_03066 VSVS12_03066 51890 52357 - Inner membrane protein Belongs to the SpmB family gene gene3065 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03066 VSVS12_03067 VSVS12_03067 VSVS12_03067 52357 53082 - uncharacterized protein gene gene3066 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03067 VSVS12_03068 VSVS12_03068 VSVS12_03068 53623 55056 + Na(+)/H(+) antiporter NhaD Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons. Can also transport lithium%3B Belongs to the NhaD Na(+)/H(+) (TC 2. A. 62) antiporter family gene gene3067 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03068 VSVS12_03069 VSVS12_03069 VSVS12_03069 55262 55591 + hypothetical protein gene gene3068 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03069 VSVS12_03070 VSVS12_03070 VSVS12_03070 55735 56934 + RNA helicase Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily%3B Contains 1 helicase ATP-binding domain%3B Contains 1 helicase C-terminal domain%3B KEGG: hde:HDEF_0325 ATP-dependent RNA helicase DeaD gene gene3069 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03070 VSVS12_03071 VSVS12_03071 VSVS12_03071 57038 57217 + hypothetical protein gene gene3070 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03071 VSVS12_03072 VSVS12_03072 mgmT mgmT 57239 57709 - Methylated-DNA--[protein]-cysteine S-methyltransferase Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated%3B Belongs to the MGMT family%3B KEGG: scb:SCAB_17781 methylated-DNA-(protein)-cysteine S-methyltransferase gene gene3071 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03072 VSVS12_03073 VSVS12_03073 VSVS12_03073 57706 59091 - DNA-3-methyladenine glycosylase II Is involved in the adaptive response to alkylation damage in DNA caused by alkylating agents. Repairs the Sp diastereomer of DNA methylphosphotriester lesions by a direct and irreversible transfer of the methyl group to one of its own cysteine residues. Also catalyzes the hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine%2C 3- methylguanine%2C 7-methylguanine%2C O2-methylthymine%2C and O2- methylcytosine from the damaged DNA polymer formed by alkylation lesions (By similarity)%3B The methylation of Alka by methylphosphotriesters in DNA leads to its activation as a transcriptional regulator that activates the transcription of its own gene and other alkylation resistance genes%3B In the C-terminal sectio%3B belongs to the alkylbase DNA glycosidase AlkA family%3B Contains 1 HTH araC/xylS-type DNA-binding domain%3B KEGG: pha:PSHAb0291 AraC family transcriptional regulator%2C regulatory protein of adaptative response / DNA-3-methyladenine glycosylase II gene gene3072 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03073 VSVS12_03074 VSVS12_03074 VSVS12_03074 59316 59519 + hypothetical protein gene gene3073 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03074 VSVS12_03075 VSVS12_03075 VSVS12_03075 59641 60522 - HTH-type transcriptional regulator HdfR Negatively regulates the transcription of the flagellar master operon flhDC by binding to the upstream region of the operon%3B Contains 1 HTH lysR-type DNA-binding domain gene gene3074 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03075 VSVS12_03076 VSVS12_03076 VSVS12_03076 60770 61126 + hypothetical protein gene gene3075 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03076 VSVS12_03077 VSVS12_03077 speA speA 61365 63275 + Arginine decarboxylase Catalyzes the biosynthesis of agmatine from arginine%3B Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily%3B KEGG: pin:Ping_0861 arginine decarboxylase gene gene3076 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03077 VSVS12_03078 VSVS12_03078 speB speB 63276 64205 + Agmatinase Catalyzes the formation of putrescine from agmatine%3B Belongs to the arginase family. Agmatinase subfamily%3B KEGG: vch:VCA0814 agmatinase gene gene3077 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03078 VSVS12_03079 VSVS12_03079 VSVS12_03079 64272 64763 - hypothetical protein gene gene3078 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03079 VSVS12_03080 VSVS12_03080 VSVS12_03080 64922 66310 - Protein I'm not dead yet Cation-independent electroneutral transporter (not associated with membrane depolarization) of a variety of tricarboxylic and dicarboxylic acid-cycle intermediates. There is also small%2C but detectable%2C transport of monocarboxylics. Transport is through the epithelium of the gut and across the plasma membranes of organs involved in intermediary metabolism and storage. Affinity for substrates is citrate > succinate > pyruvate. Fumarate%2C a-ketoglutarate%2C and glutarate are also transported%2C but not lactate. Transport mechanism that is not coupled to Na(+)%2C K(+)%2C or Cl(-). Function is shown in Xenopus oocytes and human retinal pigment epithelial (HRPE) cell lines%3B Belongs to the SLC13A/DASS transporter (TC 2. A. 47) family. NADC subfamily gene gene3079 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03080 VSVS12_03081 VSVS12_03081 VSVS12_03081 66438 67283 - Lysophospholipase KEGG: dsy:DSY0424 lysophospholipase gene gene3080 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03081 VSVS12_03082 VSVS12_03082 VSVS12_03082 67416 68027 - hypothetical protein gene gene3081 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03082 VSVS12_03083 VSVS12_03083 VSVS12_03083 68241 69263 + hypothetical protein gene gene3082 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03083 VSVS12_03084 VSVS12_03084 VSVS12_03084 69313 69825 - hypothetical protein gene gene3083 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03084 VSVS12_03085 VSVS12_03085 VSVS12_03085 69887 70273 - Inner membrane protein YecN gene gene3084 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03085 VSVS12_03086 VSVS12_03086 glgB glgB 70389 72509 - 1%2C4-alpha-glucan branching enzyme Catalyzes the formation of the alpha-1%2C6-glucosidic linkages in glycogen by scission of a 1%2C4-alpha-linked oligosaccharide from growing alpha-1%2C4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1%2C6 position%3B Belongs to the glycosyl hydrolase 13 family. GlgB subfamily%3B KEGG: vvu:VV2_1252 1%2C4-alpha-glucan branching enzyme gene gene3085 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03086 VSVS12_03087 VSVS12_03087 malQ malQ 72797 75019 - 4-alpha-glucanotransferase Belongs to the disproportionating enzyme family%3B KEGG: mvs:MVIS_3183 4-alpha-glucanotransferase gene gene3086 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03087 VSVS12_03088 VSVS12_03088 VSVS12_03088 75125 77578 - Glycogen phosphorylase Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However%2C all known phosphorylases share catalytic and structural properties. Belongs to the glycogen phosphorylase family%3B KEGG: vcm:VCM66_A0013 starch phosphorylase gene gene3087 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03088 VSVS12_03089 VSVS12_03089 VSVS12_03089 78149 80905 + HTH-type transcriptional regulator MalT Positively regulates the transcription of the maltose regulon whose gene products are responsible for uptake and catabolism of malto-oligosaccharides. Binds and recognizes a DNA motif (called the malT box): 5'-GGA[TG]GA-3'%3B Contains 1 HTH luxR-type DNA-binding domain gene gene3088 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03089 VSVS12_03090 VSVS12_03090 nfnB nfnB 81137 81796 + Major NAD(P)H-flavin oxidoreductase Involved in bioluminescence. It is a good supplier of reduced flavin mononucleotide (FMNH2) to the bioluminescence reaction. Major FMN reductase. It is capable of using both NADH and NADPH as electron donors. As electron acceptor%2C FMN is the most effective%2C FAD is considerably effective%2C and riboflavin is the least effective. Belongs to the nitroreductase family%3B KEGG: awd:AWOD_II_0195 nitroreductase / dihydropteridine reductase%3B Oxidoreductases gene gene3089 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03090 VSVS12_03091 VSVS12_03091 VSVS12_03091 82125 83000 + hypothetical protein gene gene3090 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03091 VSVS12_03092 VSVS12_03092 VSVS12_03092 83219 85414 - Chitinase Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily%3B KEGG: scq:SCULI_v1c08220 chitinase gene gene3091 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03092 VSVS12_03093 VSVS12_03093 VSVS12_03093 85698 86465 - Prolyl aminopeptidase Specifically catalyzes the removal of N-terminal proline residues from peptides%3B Belongs to the peptidase S33 family%3B KEGG: mca:MCA1737 proline iminopeptidase gene gene3092 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03093 VSVS12_03094 VSVS12_03094 VSVS12_03094 86671 87672 - 3'%2C5'-cyclic-nucleotide phosphodiesterase Seems to allow the organism to grow on cAMP. Belongs to the cAMP phosphodiesterase class-II family%3B KEGG: vfi:VF_1256 3'%2C5'-cyclic-nucleotide phosphodiesterase gene gene3093 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03094 VSVS12_03095 VSVS12_03095 VSVS12_03095 88006 88299 + Protein-N(pi)-phosphohistidine--sugar phosphotransferase The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS)%2C a major carbohydrate active -transport system%2C catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in glucose transport (By similarity)%3B Contains 1 PTS EIIA type-1 domain%3B Contains 1 PTS EIIB type-1 domain%3B Contains 1 PTS EIIC type-1 domain%3B KEGG: psi:S70_15555 PTS system%2C N-acetylglucosamine-specific IIA component gene gene3094 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03095 VSVS12_03096 VSVS12_03096 bglA bglA 88339 89751 + 6-phospho-beta-glucosidase Belongs to the glycosyl hydrolase 1 family%3B KEGG: lmo:lmo0319 6-phospho-beta-glucosidase gene gene3095 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03096 VSVS12_03097 VSVS12_03097 VSVS12_03097 90036 90329 + Sugar transporter SemiSWEET The homodimer mediates transmembrane sugar transport down a concentration gradient. Transport is probably effected by rocking-type movements%2C where a cargo-binding cavity opens first on one and then on the other side of the membrane%3B Contains 1 PQ-loop domain gene gene3096 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03097 VSVS12_03098 VSVS12_03098 VSVS12_03098 90337 90774 - DNA-directed DNA polymerase Catalyzes the transfer of an acetyl group from acetyl coenzyme A (AcCoA) to an acceptor substrate and releases both CoA and the acetylated product. It prefers glucosamine 6-phosphate or dopamine. It can also use the thialysine%2C N(8)-acetylspermidine%2C chloramphenicol%2C puromycin%2C polymyxin B%2C and 4-aminobutyrate ethyl ester%3B Contains 1 N-acetyltransferase domain%3B KEGG: bww:bwei_2369 DNA polymerase III subunit beta gene gene3097 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03098 VSVS12_03099 VSVS12_03099 VSVS12_03099 90903 91004 + hypothetical protein gene gene3098 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03099 VSVS12_03100 VSVS12_03100 VSVS12_03100 91040 91516 + hypothetical protein gene gene3099 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03100 VSVS12_03101 VSVS12_03101 VSVS12_03101 91607 92083 - uncharacterized protein To Rickettsia 17 kDa surface antigen gene gene3100 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03101 VSVS12_03102 VSVS12_03102 VSVS12_03102 92279 94618 - hypothetical protein gene gene3101 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03102 VSVS12_03103 VSVS12_03103 lyxK lyxK 94802 96436 - L-xylulokinase Belongs to the FGGY kinase family%3B KEGG: eco:b3580 L-xylulokinase gene gene3102 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03103 VSVS12_03104 VSVS12_03104 VSVS12_03104 96448 97407 - L-arabinose ABC transporter permease protein AraH Part of the ABC transporter complex AraFGH involved in L-arabinose import. Responsible for the translocation of the substrate across the membrane (Probable)%3B Belongs to the binding-protein-dependent transport system permease family. AraH/RbsC subfamily gene gene3103 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03104 VSVS12_03105 VSVS12_03105 VSVS12_03105 97407 98405 - Ribose transport system permease protein Part of the binding-protein-dependent transport system for ribose. Probably responsible for the translocation of the substrate across the membrane (By similarity)%3B Belongs to the binding-protein-dependent transport system permease family. AraH/RbsC subfamily gene gene3104 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03105 VSVS12_03106 VSVS12_03106 araG araG 98398 99891 - Monosaccharide-transporting ATPase Part of the ABC transporter complex SsuABC involved in aliphatic sulfonates import. Responsible for energy coupling to the transport system%3B Belongs to the ABC transporter superfamily. Aliphatic sulfonates importer (TC 3. A. 1. 17. 2) family%3B Contains 1 ABC transporter domain%3B KEGG: ebt:EBL_c15690 L-arabinose transport system ATP-binding protein gene gene3105 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03106 VSVS12_03107 VSVS12_03107 VSVS12_03107 99988 100962 - Autoinducer 2-binding protein LsrB Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Binds AI-2 and delivers it to the LsrC and LsrD permeases (By similarity)%3B Belongs to the bacterial solute-binding protein 2 family gene gene3106 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03107 VSVS12_03108 VSVS12_03108 VSVS12_03108 101530 102846 + hypothetical protein gene gene3107 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03108 VSVS12_03109 VSVS12_03109 VSVS12_03109 102894 103880 - Cytochrome-c peroxidase KEGG: vpa:VP1718 cytochrome c peroxidase gene gene3108 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03109 VSVS12_03110 VSVS12_03110 VSVS12_03110 104255 104803 - hypothetical protein gene gene3109 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03110 VSVS12_03111 VSVS12_03111 VSVS12_03111 104855 106018 - HTH-type transcriptional regulator HmrR Regulates the transcription of actP. It detects cytoplasmic copper stress and activates transcription in response to increasing copper concentrations. In the absence of copper%2C it negatively regulates the transcription of actP%3B Contains 1 HTH merR-type DNA-binding domain gene gene3110 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03111 VSVS12_03112 VSVS12_03112 sod1 sod1 106399 106911 + Superoxide dismutase Destroys radicals which are normally produced within the cells and which are toxic to biological systems%3B Belongs to the Cu-Zn superoxide dismutase family%3B KEGG: vch:VC1583 superoxide dismutase%2C Cu-Zn family gene gene3111 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03112 VSVS12_03113 VSVS12_03113 VSVS12_03113 107078 108271 + Transposase for insertion sequence element IS1001 Involved in the transposition of the insertion sequence. Belongs to the transposase 12 family gene gene3112 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03113 VSVS12_03114 VSVS12_03114 VSVS12_03114 108290 109180 - putative RuBisCO transcriptional regulator Trans-acting transcriptional regulator of RuBisCO genes (rbcL and rbcS) expression%3B Contains 1 HTH lysR-type DNA-binding domain gene gene3113 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03114 VSVS12_03115 VSVS12_03115 VSVS12_03115 109334 109762 + hypothetical protein gene gene3114 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03115 VSVS12_03116 VSVS12_03116 VSVS12_03116 109852 111435 - Glutathione synthase KEGG: swd:Swoo_2096 glutathione synthase gene gene3115 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03116 VSVS12_03117 VSVS12_03117 VSVS12_03117 111906 112652 + putative phosphatase Belongs to the PHP family gene gene3116 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03117 VSVS12_03118 VSVS12_03118 VSVS12_03118 112733 113863 - hypothetical protein gene gene3117 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03118 VSVS12_03119 VSVS12_03119 VSVS12_03119 113872 115014 - hypothetical protein gene gene3118 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03119 VSVS12_03120 VSVS12_03120 VSVS12_03120 115250 115630 - hypothetical protein gene gene3119 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03120 VSVS12_03121 VSVS12_03121 VSVS12_03121 115907 117106 + hypothetical protein gene gene3120 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03121 VSVS12_03122 VSVS12_03122 VSVS12_03122 117210 117866 - hypothetical protein gene gene3121 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03122 VSVS12_03123 VSVS12_03123 phnA phnA 117962 118291 - Phosphonoacetate hydrolase KEGG: asi:ASU2_10620 phosphonoacetate hydrolase gene gene3122 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03123 VSVS12_03124 VSVS12_03124 catA catA 118492 119151 + Chloramphenicol O-acetyltransferase This enzyme is an effector of chloramphenicol resistance in bacteria. Belongs to the chloramphenicol acetyltransferase family%3B KEGG: pmr:PMI0728 chloramphenicol O-acetyltransferase type A gene gene3123 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03124 VSVS12_03125 VSVS12_03125 VSVS12_03125 119400 119972 + hypothetical protein gene gene3124 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03125 VSVS12_03126 VSVS12_03126 VSVS12_03126 120090 123242 - Antibiotic efflux pump membrane transporter ArpB The inner membrane transporter component of an antibiotic efflux pump. Confers resistance to numerous structurally unrelated antibiotics such as carbenicillin%2C chloramphenicol%2C erythromycin%2C novobiocin%2C streptomycin and tetracycline. Is not involved in organic solvent efflux. Belongs to the resistance-nodulation-cell division (RND) (TC 2. A. 6) family gene gene3125 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03126 VSVS12_03127 VSVS12_03127 VSVS12_03127 123252 124397 - Membrane fusion protein MtrC Cell membrane lipoprotein%2C involved in cell membrane permeability to hydrophobic compounds such as antibiotics%2C dyes and detergents. Belongs to the membrane fusion protein (MFP) (TC 8. A. 1) family gene gene3126 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03127 VSVS12_03128 VSVS12_03128 VSVS12_03128 125313 125693 - DNA-binding protein Binds double-stranded DNA (dsDNA) gene gene3127 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03128 VSVS12_03129 VSVS12_03129 VSVS12_03129 125860 127191 + Putative beta-lactamase HcpC May hydrolyze 6-aminopenicillinic acid and 7- aminocephalosporanic acid (ACA) derivatives%3B Belongs to the hcp beta-lactamase family%3B Contains 7 TPR repeats gene gene3128 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03129 VSVS12_03130 VSVS12_03130 VSVS12_03130 127359 127826 - Peptide chain release factor N(5)-glutamine methyltransferase KEGG: mham:J450_04300 release factor glutamine methyltransferase gene gene3129 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03130 VSVS12_03131 VSVS12_03131 VSVS12_03131 127989 129263 - 2-methyl-aconitate isomerase Catalyzes the isomerization of 2-methyl-trans-aconitate to yield 2-methyl-cis-aconitate through a base-catalyzed proton abstraction coupled with a rotation about C2-C3 bond of 2-methyl- aconitate%3B Belongs to the PrpF family gene gene3130 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03131 VSVS12_03132 VSVS12_03132 acnA acnA 129277 131880 - Aconitate hydratase Involved in the catabolism of short chain fatty acids (SCFA) via the 2-methylcitrate cycle II (propionate degradation route). In vivo under anaerobic conditions%2C AcnD catalyzes the stereospecific dehydration of (2S%2C3S)-methylcitrate (2-MC) to yield the trans isomer of 2-methyl-aconitate (2-MCA). AcnD can also accept citrate and cis-aconitate%2C but with a lower efficiency. 2-methylisocitrate and isocitrate are not substrates%3B Belongs to the aconitase/IPM isomerase family%3B KEGG: vtu:IX91_07225 aconitate hydratase gene gene3131 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03132 VSVS12_03133 VSVS12_03133 prpC prpC 131973 133115 - 2-methylcitrate synthase Involved in the catabolism of short chain fatty acids (SCFA) via the tricarboxylic acid (TCA)(acetyl degradation route) and via the 2-methylcitrate cycle II (propionate degradation route). Catalyzes the Claisen condensation of propionyl-CoA and oxaloacetate (OAA) to yield (2S%2C3S)-2-methylcitrate (2-MC) and CoA (PubMed:14702315). Catalyzes the condensation of oxaloacetate with acetyl-CoA (By similarity)%3B Belongs to the citrate synthase family%3B KEGG: vch:VC1337 2-methylcitrate synthase gene gene3132 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03133 VSVS12_03134 VSVS12_03134 prpB prpB 133245 134162 - Methylisocitrate lyase Involved in the catabolism of short chain fatty acids (SCFA) via the 2-methylcitrate cycle I (propionate degradation route). Catalyzes the thermodynamically favored C-C bond cleavage reaction of (2R%2C3S)-2-methylisocitrate to yield pyruvate and succinate via an alpha-carboxy-carbanion intermediate%3B Belongs to the isocitrate lyase/PEP mutase superfamily. Methylisocitrate lyase family%3B KEGG: vch:VC1336 methylisocitrate lyase gene gene3133 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03134 VSVS12_03135 VSVS12_03135 VSVS12_03135 134269 134994 - putative HTH-type transcriptional regulator YdhC Contains 1 HTH gntR-type DNA-binding domain gene gene3134 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03135 VSVS12_03136 VSVS12_03136 VSVS12_03136 135254 135631 - hypothetical protein gene gene3135 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03136 VSVS12_03137 VSVS12_03137 VSVS12_03137 135726 136031 - Putative monooxygenase YdhR May function as monoxygenase and play a role in the metabolism of aromatic compounds gene gene3136 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03137 VSVS12_03138 VSVS12_03138 VSVS12_03138 136175 137065 + HTH-type transcriptional regulator IlvY This protein activates the transcription of the ilvC gene in the presence of acetolactate or acetohydroxybutyrate. IlvY is also a negative regulator of its own expression. Contains 1 HTH lysR-type DNA-binding domain gene gene3137 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03138 VSVS12_03139 VSVS12_03139 nanM nanM 137146 138225 - N-acetylneuraminate epimerase Contains 4 Kelch repeats%3B KEGG: vcl:VCLMA_A1535 N-acetylneuraminate epimerase gene gene3138 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03139 VSVS12_03140 VSVS12_03140 VSVS12_03140 138229 139380 - N-acetylneuraminate epimerase Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer%2C accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac%2C which is likely taken up in the beta-anomer. In addition%2C the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses%3B Belongs to the NanM family%3B Contains 7 Kelch repeats%3B KEGG: hin:HI0148 N-acetylneuraminate epimerase gene gene3139 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03140 VSVS12_03141 VSVS12_03141 VSVS12_03141 139545 140432 - HTH-type transcriptional regulator HexR Represses the expression of the hex regulon (zwf%2C eda%2C glp and gap)%3B Contains 1 HTH rpiR-type DNA-binding domain%3B Contains 1 SIS domain gene gene3140 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03141 VSVS12_03142 VSVS12_03142 nanA nanA 140565 141461 - N-acetylneuraminate lyase Catalyzes the condensation of (S)-aspartate-beta- semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)%3B Belongs to the DapA family%3B KEGG: ype:YPO3024 N-acetylneuraminate lyase gene gene3141 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03142 VSVS12_03143 VSVS12_03143 VSVS12_03143 141525 142808 - Sialic acid TRAP transporter permease protein SiaT Part of the tripartite ATP-independent periplasmic (TRAP) transport system SiaPT involved in the uptake of sialic acid%3B In the N-terminal sectio%3B belongs to the TRAP transporter small permease family%3B In the C-terminal sectio%3B belongs to the TRAP transporter large permease family gene gene3142 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03143 VSVS12_03144 VSVS12_03144 VSVS12_03144 142815 143324 - Sialic acid TRAP transporter permease protein SiaT Part of the tripartite ATP-independent periplasmic (TRAP) transport system SiaPT involved in the uptake of sialic acid%3B In the N-terminal sectio%3B belongs to the TRAP transporter small permease family%3B In the C-terminal sectio%3B belongs to the TRAP transporter large permease family gene gene3143 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03144 VSVS12_03145 VSVS12_03145 VSVS12_03145 143402 144367 - uncharacterized protein Belongs to the bacterial solute-binding protein 7 family gene gene3144 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03145 VSVS12_03146 VSVS12_03146 nanE nanE 144645 145343 + N-acylglucosamine-6-phosphate 2-epimerase Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)%3B Belongs to the NanE family%3B KEGG: vvy:VVA1204 N-acylglucosamine-6-phosphate 2-epimerase gene gene3145 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03146 VSVS12_03147 VSVS12_03147 nanK nanK 145343 146224 + N-acylmannosamine kinase Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P%3B Belongs to the ROK (NagC/XylR) family. NanK subfamily%3B KEGG: yru:BD65_957 N-acylmannosamine kinase gene gene3146 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03147 VSVS12_03148 VSVS12_03148 VSVS12_03148 146227 147360 + N-acetylglucosamine-6-phosphate deacetylase Involved in the first committed step in the biosynthesis of amino-sugar-nucleotides. Catalyzes the hydrolysis of the N- acetyl group of N-acetylglucosamine-6-phosphate (GlcNAc-6-P) to yield glucosamine 6-phosphate and acetate%3B Belongs to the NagA family%3B KEGG: vch:VC1783 N-acetylglucosamine-6-phosphate deacetylase gene gene3147 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03148 VSVS12_03149 VSVS12_03149 VSVS12_03149 147447 148358 - hypothetical protein gene gene3148 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03149 VSVS12_03150 VSVS12_03150 VSVS12_03150 148724 149686 + hypothetical protein gene gene3149 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03150 VSVS12_03151 VSVS12_03151 VSVS12_03151 150014 151591 - hypothetical protein gene gene3150 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03151 VSVS12_03152 VSVS12_03152 VSVS12_03152 151925 152299 + hypothetical protein To H. influenzae HI_1709 gene gene3151 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03152 VSVS12_03153 VSVS12_03153 katE katE 152381 153811 - Catalase Decomposes hydrogen peroxide into water and oxyge%3B serves to protect cells from the toxic effects of hydrogen peroxide. Could protect cells in nodules which have a high potential to produce hydrogen peroxide because of the strong reducing conditions required for nitrogen fixation and the action of several proteins. Belongs to the catalase family%3B KEGG: vha:VIBHAR_05192 catalase gene gene3152 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03153 VSVS12_03154 VSVS12_03154 VSVS12_03154 154437 155600 + Tyrosine-specific transport protein Involved in transporting tyrosine across the cytoplasmic membrane%3B Belongs to the amino acid/polyamine transporter 2 family. Mtr/TnaB/TyrP permease subfamily gene gene3153 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03154 VSVS12_03155 VSVS12_03155 VSVS12_03155 155830 156993 + Tyrosine-specific transport protein Involved in transporting tyrosine across the cytoplasmic membrane%3B Belongs to the amino acid/polyamine transporter 2 family. Mtr/TnaB/TyrP permease subfamily gene gene3154 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03155 VSVS12_03156 VSVS12_03156 VSVS12_03156 157321 158736 - hypothetical protein gene gene3155 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03156 VSVS12_03157 VSVS12_03157 malX malX 158874 160457 - Protein-N(pi)-phosphohistidine--sugar phosphotransferase The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS)%2C a major carbohydrate active -transport system%2C catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in glucose transport (By similarity)%3B Contains 1 PTS EIIA type-1 domain%3B Contains 1 PTS EIIB type-1 domain%3B Contains 1 PTS EIIC type-1 domain%3B KEGG: cdg:CDBI1_14950 PTS system%2C maltose and glucose-specific IIB component gene gene3156 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03157 VSVS12_03158 VSVS12_03158 VSVS12_03158 160461 161867 - Succinyl-diaminopimelate desuccinylase Belongs to the peptidase M20A family%3B KEGG: lmo:lmo1620 succinyl-diaminopimelate desuccinylase gene gene3157 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03158 VSVS12_03159 VSVS12_03159 VSVS12_03159 161927 162622 - Ribose-5-phosphate isomerase Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate%3B Belongs to the ribose 5-phosphate isomerase family%3B KEGG: vsp:VS_0167 ribose 5-phosphate isomerase A gene gene3158 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03159 VSVS12_03160 VSVS12_03160 VSVS12_03160 162623 164620 - Transketolase Plays an essential role in total transketolase activity and cell proliferation in cancer cell%3B after transfection with anti-TKTL1 siRNA%2C total transketolase activity dramatically decreases and proliferation was significantly inhibited in cancer cells. Plays a pivotal role in carcinogenesis (By similarity)%3B Belongs to the transketolase family%3B KEGG: sehc:A35E_00113 transketolase gene gene3159 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03160 VSVS12_03161 VSVS12_03161 talA talA 164635 165588 - Transaldolase Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway%3B Belongs to the transaldolase family. Type 1 subfamily%3B KEGG: hde:HDEF_0722 transaldolase gene gene3160 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03161 VSVS12_03162 VSVS12_03162 VSVS12_03162 165585 166328 - uncharacterized protein Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family gene gene3161 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03162 VSVS12_03163 VSVS12_03163 VSVS12_03163 166352 167509 - Alcohol dehydrogenase Involved in ethanol oxidation in mitochondria%3B Belongs to the iron-containing alcohol dehydrogenase family%3B KEGG: rho:RHOM_16595 alcohol dehydrogenase gene gene3162 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03163 VSVS12_03164 VSVS12_03164 VSVS12_03164 167581 168291 - Ribulose-phosphate 3-epimerase KEGG: nis:NIS_0320 ribulose-phosphate 3-epimerase gene gene3163 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03164 VSVS12_03165 VSVS12_03165 VSVS12_03165 168301 169143 - Pyridoxal phosphate phosphatase YbhA Catalyzes the dephosphorylation of pyridoxal-phosphate (PLP). Can also hydrolyze erythrose-4-phosphate (Ery4P) and fructose-1%2C6-bis-phosphate (Fru1%2C6bisP)%3B Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family gene gene3164 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03165 VSVS12_03166 VSVS12_03166 VSVS12_03166 169225 170133 + HTH-type transcriptional regulator UlaR Represses ulaG and the ulaABCDEF operon%3B Contains 1 HTH deoR-type DNA-binding domain gene gene3165 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03166 VSVS12_03167 VSVS12_03167 VSVS12_03167 170525 171520 + hypothetical protein gene gene3166 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03167 VSVS12_03168 VSVS12_03168 VSVS12_03168 171593 172240 - hypothetical protein gene gene3167 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03168 VSVS12_03169 VSVS12_03169 VSVS12_03169 172243 172827 - hypothetical protein gene gene3168 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03169 VSVS12_03170 VSVS12_03170 VSVS12_03170 172922 173251 - hypothetical protein gene gene3169 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03170 VSVS12_03171 VSVS12_03171 VSVS12_03171 173266 173886 - hypothetical protein gene gene3170 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03171 VSVS12_03172 VSVS12_03172 VSVS12_03172 174429 174815 + hypothetical protein gene gene3171 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03172 VSVS12_03173 VSVS12_03173 VSVS12_03173 174863 175075 + Response regulator protein TmoT Member of the two-component regulatory system TmoS/TmoT involved in the regulation of toluene degradation. Induces expression of tmoX operon%3B Contains 1 HTH luxR-type DNA-binding domain%3B Contains 1 response regulatory domain gene gene3172 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03173 VSVS12_03174 VSVS12_03174 VSVS12_03174 175120 175518 - uncharacterized protein gene gene3173 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03174 VSVS12_03175 VSVS12_03175 VSVS12_03175 175625 176404 + hypothetical protein gene gene3174 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03175 VSVS12_03176 VSVS12_03176 VSVS12_03176 176605 178266 + Methyl-accepting chemotaxis protein Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment%2C transduce a signal from the outside to the inside of the cell%2C and facilitate sensory adaptation through the variation of the level of methylation. Chemoreceptor for malate%3B Contains 1 HAMP domain%3B Contains 1 methyl-accepting transducer domain gene gene3175 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03176 VSVS12_03177 VSVS12_03177 VSVS12_03177 178361 178720 - Inner membrane protein To E. coli YhaI gene gene3176 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03177 VSVS12_03178 VSVS12_03178 trmK trmK 179190 179894 - tRNA (adenine(22)-N(1))-methyltransferase KEGG: slo:Shew_2722 tRNA (adenine22-N1)-methyltransferase gene gene3177 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03178 VSVS12_03179 VSVS12_03179 VSVS12_03179 180112 180678 - hypothetical protein gene gene3178 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03179 VSVS12_03180 VSVS12_03180 VSVS12_03180 180942 181844 - HTH-type transcriptional activator AaeR Activates transcription of the aaeXAB operon%3B Contains 1 HTH lysR-type DNA-binding domain gene gene3179 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03180 VSVS12_03181 VSVS12_03181 VSVS12_03181 181970 183019 + p-hydroxybenzoic acid efflux pump subunit AaeA Forms an efflux pump with AaeB%3B Belongs to the membrane fusion protein (MFP) (TC 8. A. 1) family gene gene3180 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03181 VSVS12_03182 VSVS12_03182 VSVS12_03182 183032 184102 + hypothetical protein gene gene3181 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03182 VSVS12_03183 VSVS12_03183 VSVS12_03183 184180 184896 - Glucose-1-phosphate adenylyltransferase Belongs to the TACO1 family%3B KEGG: pmf:P9303_05381 glucose-1-phosphate adenylyltransferase gene gene3182 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03183 VSVS12_03184 VSVS12_03184 VSVS12_03184 184982 185191 - hypothetical protein gene gene3183 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03184 VSVS12_03185 VSVS12_03185 VSVS12_03185 185341 185538 - hypothetical protein gene gene3184 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03185 VSVS12_03186 VSVS12_03186 VSVS12_03186 185909 186757 + Methionine import ATP-binding protein MetN Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system%3B Belongs to the ABC transporter superfamily. Methionine importer (TC 3. A. 1. 24) family%3B Contains 1 ABC transporter domain gene gene3185 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03186 VSVS12_03187 VSVS12_03187 VSVS12_03187 186754 187686 + Peptide transport system ATP-binding protein SapF Involved in a peptide intake transport system that plays a role in the resistance to antimicrobial peptides%3B Belongs to the ABC transporter superfamily%3B Contains 1 ABC transporter domain gene gene3186 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03187 VSVS12_03188 VSVS12_03188 VSVS12_03188 187683 188156 + hypothetical protein gene gene3187 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03188 VSVS12_03189 VSVS12_03189 VSVS12_03189 188506 190476 - hypothetical protein gene gene3188 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03189 VSVS12_03190 VSVS12_03190 VSVS12_03190 191723 192940 + Plasmid partition protein A This protein is essential for plasmid partition. It ensures the proper distribution of newly replicated plasmids to daughter cells during cell division. ParA is trans-acting. Belongs to the ParA family gene gene3189 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03190 VSVS12_03191 VSVS12_03191 VSVS12_03191 192948 193919 + hypothetical protein gene gene3190 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03191 VSVS12_03192 VSVS12_03192 VSVS12_03192 193878 193982 - hypothetical protein gene gene3191 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03192 VSVS12_03193 VSVS12_03193 VSVS12_03193 193979 195172 - Transposase for insertion sequence element IS1001 Involved in the transposition of the insertion sequence. Belongs to the transposase 12 family gene gene3192 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03193 VSVS12_03194 VSVS12_03194 tmcA tmcA 195387 197483 + tRNA(Met) cytidine acetyltransferase Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met)%2C by using acetyl-CoA as an acetyl donor and ATP (or GTP)%3B Belongs to the TmcA family%3B Contains 1 N-acetyltransferase domain%3B KEGG: vch:VCA1112 tRNA(Met) cytidine acetyltransferase gene gene3193 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03194 VSVS12_03195 VSVS12_03195 VSVS12_03195 198190 198489 + STAS-domain containing protein Contains 1 STAS domain gene gene3194 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03195 VSVS12_03196 VSVS12_03196 VSVS12_03196 198500 200197 + Protein EIN4 Ethylene receptor related to bacterial two-component regulators. Acts as a redundant negative regulator of ethylene signaling. Belongs to the ethylene receptor family%3B Contains 1 GAF domain%3B Contains 1 histidine kinase domain%3B Contains 1 response regulatory domain%3B KEGG: cvi:CV_3503 null%3B Phosphotransferases with a nitrogenous group as acceptor gene gene3195 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03196 VSVS12_03197 VSVS12_03197 VSVS12_03197 200327 202624 - Formate C-acetyltransferase Contains 1 glycine radical domain%3B Contains 1 PFL domain%3B KEGG: vha:VIBHAR_02963 formate C-acetyltransferase gene gene3196 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03197 VSVS12_03198 VSVS12_03198 VSVS12_03198 202927 203571 + hypothetical protein gene gene3197 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03198 VSVS12_03199 VSVS12_03199 VSVS12_03199 203568 204752 + Dityrosine transporter Prospore-specific dityrosine transporter responsible for translocation of dityrosine through the prospore membrane and required for the formation of the outermost layer of the spore%3B Belongs to the major facilitator superfamily. CAR1 family gene gene3198 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03199 VSVS12_03200 VSVS12_03200 VSVS12_03200 204990 205460 - hypothetical protein gene gene3199 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03200 VSVS12_03201 VSVS12_03201 VSVS12_03201 205460 207133 - hypothetical protein gene gene3200 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03201 VSVS12_03202 VSVS12_03202 VSVS12_03202 207151 207750 - Baseplate protein Baseplate protein that may be part of the wedges of the baseplate. Plays a role in tail assembly%3B Belongs to the P2likevirus gpI protein family gene gene3201 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03202 VSVS12_03203 VSVS12_03203 VSVS12_03203 207747 208952 - hypothetical protein gene gene3202 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03203 VSVS12_03204 VSVS12_03204 VSVS12_03204 209061 209642 + hypothetical protein gene gene3203 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03204 VSVS12_03205 VSVS12_03205 VSVS12_03205 209706 211643 + uncharacterized protein To B. subtilis XkdO gene gene3204 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03205 VSVS12_03206 VSVS12_03206 VSVS12_03206 211601 212809 - hypothetical protein gene gene3205 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03206 VSVS12_03207 VSVS12_03207 VSVS12_03207 212994 213443 + hypothetical protein gene gene3206 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03207 VSVS12_03208 VSVS12_03208 VSVS12_03208 213611 214636 + Site-specific DNA-methyltransferase (adenine-specific) This methylase recognizes the double-stranded sequence GTTAAC%2C causes specific methylation on A-5 on both strands%2C and protects the DNA from cleavage by the HpaI endonuclease. Belongs to the N(4)/N(6)-methyltransferase family%3B KEGG: xbo:XBJ1_1254 site-specific DNA-methyltransferase (adenine-specific) gene gene3207 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03208 VSVS12_03209 VSVS12_03209 VSVS12_03209 214671 214889 - hypothetical protein gene gene3208 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03209 VSVS12_03210 VSVS12_03210 VSVS12_03210 215105 216202 + Nucleoid-associated protein YejK Belongs to the YejK family gene gene3209 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03210 VSVS12_03211 VSVS12_03211 VSVS12_03211 216215 217471 + hypothetical protein gene gene3210 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03211 VSVS12_03212 VSVS12_03212 VSVS12_03212 217547 218836 - hypothetical protein gene gene3211 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03212 VSVS12_03213 VSVS12_03213 VSVS12_03213 218827 219936 - hypothetical protein gene gene3212 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03213 VSVS12_03214 VSVS12_03214 VSVS12_03214 219887 220408 - hypothetical protein gene gene3213 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03214 VSVS12_03215 VSVS12_03215 VSVS12_03215 220418 221416 - hypothetical protein gene gene3214 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03215 VSVS12_03216 VSVS12_03216 VSVS12_03216 221475 221915 - Coupling protein TraD Conjugative DNA transfer (CDT) is the unidirectional transfer of ssDNA plasmid from a donor to a recipient cell. It is the central mechanism by which antibiotic resistance and virulence factors are propagated in bacterial populations. Couples the transferosome to a type IV secretion system. Probably forms a pore through which single-stranded plasmid DNA is transferred to the secretion system. Plasmid specificity is conferred by the TraD- TraM pair (By similarity)%3B Belongs to the TrwB coupling protein family gene gene3215 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03216 VSVS12_03217 VSVS12_03217 VSVS12_03217 221917 222252 - hypothetical protein gene gene3216 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03217 VSVS12_03218 VSVS12_03218 VSVS12_03218 222255 223217 - hypothetical protein gene gene3217 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03218 VSVS12_03219 VSVS12_03219 VSVS12_03219 223221 223709 - hypothetical protein gene gene3218 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03219 VSVS12_03220 VSVS12_03220 VSVS12_03220 223706 225040 - Putative prophage major tail sheath protein Belongs to the myoviridae tail sheath protein family gene gene3219 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03220 VSVS12_03221 VSVS12_03221 VSVS12_03221 225116 225781 - hypothetical protein gene gene3220 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03221 VSVS12_03222 VSVS12_03222 VSVS12_03222 225778 226116 - hypothetical protein gene gene3221 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03222 VSVS12_03223 VSVS12_03223 VSVS12_03223 226292 226927 - hypothetical protein gene gene3222 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03223 VSVS12_03224 VSVS12_03224 VSVS12_03224 226927 228516 - hypothetical protein gene gene3223 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03224 VSVS12_03225 VSVS12_03225 VSVS12_03225 228509 229051 - hypothetical protein gene gene3224 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03225 VSVS12_03226 VSVS12_03226 VSVS12_03226 229184 229846 + hypothetical protein gene gene3225 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03226 VSVS12_03227 VSVS12_03227 VSVS12_03227 229843 230433 + hypothetical protein gene gene3226 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03227 VSVS12_03228 VSVS12_03228 VSVS12_03228 230426 230830 + hypothetical protein gene gene3227 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03228 VSVS12_03229 VSVS12_03229 VSVS12_03229 230827 231051 + hypothetical protein gene gene3228 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03229 VSVS12_03230 VSVS12_03230 VSVS12_03230 231039 232031 + hypothetical protein gene gene3229 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03230 VSVS12_03231 VSVS12_03231 VSVS12_03231 232028 233158 + hypothetical protein gene gene3230 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03231 VSVS12_03232 VSVS12_03232 VSVS12_03232 233162 233497 + hypothetical protein gene gene3231 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03232 VSVS12_03233 VSVS12_03233 VSVS12_03233 233500 233709 + hypothetical protein gene gene3232 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03233 VSVS12_03234 VSVS12_03234 VSVS12_03234 233684 234097 + hypothetical protein gene gene3233 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03234 VSVS12_03235 VSVS12_03235 VSVS12_03235 234094 234615 + hypothetical protein gene gene3234 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03235 VSVS12_03236 VSVS12_03236 VSVS12_03236 234814 235065 - hypothetical protein gene gene3235 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03236 VSVS12_03237 VSVS12_03237 VSVS12_03237 235077 235505 - hypothetical protein gene gene3236 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03237 VSVS12_03238 VSVS12_03238 VSVS12_03238 235607 235861 - hypothetical protein gene gene3237 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03238 VSVS12_03239 VSVS12_03239 VSVS12_03239 235849 236373 - hypothetical protein gene gene3238 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03239 VSVS12_03240 VSVS12_03240 VSVS12_03240 236494 236727 - hypothetical protein gene gene3239 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03240 VSVS12_03241 VSVS12_03241 VSVS12_03241 236824 237270 - hypothetical protein gene gene3240 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03241 VSVS12_03242 VSVS12_03242 VSVS12_03242 237260 237436 - hypothetical protein gene gene3241 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03242 VSVS12_03243 VSVS12_03243 VSVS12_03243 237442 238116 - hypothetical protein gene gene3242 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03243 VSVS12_03244 VSVS12_03244 VSVS12_03244 238261 238566 - hypothetical protein gene gene3243 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03244 VSVS12_03245 VSVS12_03245 VSVS12_03245 238581 238754 - hypothetical protein gene gene3244 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03245 VSVS12_03246 VSVS12_03246 VSVS12_03246 238754 239134 - hypothetical protein gene gene3245 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03246 VSVS12_03247 VSVS12_03247 VSVS12_03247 239124 239354 - hypothetical protein gene gene3246 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03247 VSVS12_03248 VSVS12_03248 VSVS12_03248 239496 240155 - hypothetical protein gene gene3247 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03248 VSVS12_03249 VSVS12_03249 VSVS12_03249 240157 240345 - hypothetical protein gene gene3248 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03249 VSVS12_03250 VSVS12_03250 VSVS12_03250 240327 240572 - hypothetical protein gene gene3249 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03250 VSVS12_03251 VSVS12_03251 VSVS12_03251 240578 241000 - hypothetical protein gene gene3250 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03251 VSVS12_03252 VSVS12_03252 VSVS12_03252 241000 241917 - ATP-dependent target DNA activator B Selects the target DNA sites for transposition. Recruits DDE-recombinase A to the target sites and catalytically activates it. Displays non-specific DNA-binding properties. Polymerizes as helical filaments around the DNA. Coating of the DNA by the target DNA activator B might play a role in favoring target-primed replication over integration. Prevents self-integration into an integrated copy of the viral genome. This mechanism is called target immunity and is achieved by two mechanisms: first%2C the target DNA activator B dissociates from the viral genome ends upon interaction in cis with DDE-recombinase A%2C which makes the viral genome ends a poor target for new insertions. Second%2C the interior of the viral genome may also ne protected from integration events by the target DNA activator B being strongly bound throughout the whole viral genome (By similarity)%3B Belongs to the AAA ATPase family gene gene3251 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03252 VSVS12_03253 VSVS12_03253 VSVS12_03253 241944 243998 - DDE-recombinase Responsible for viral genome integration into the host chromosome. During integration of the incoming virus%2C DDE- recombinase A cleaves both viral DNA ends and the resulting 3'-OH perform a nucleophilic attack of the host DNA. The 5' flanking DNA attached to the ends of the viral genome (flaps) are resected by the DDE-recombinase A endonuclease activity%2C with the help of host chaperone ClpX. The gaps created in the host chromosome by the viral genome insertion are repaired by the host primary machinery for double-strand break repair. Responsible for replication of the viral genome by replicative transposition. During replicative transposition%2C DDE- recombinase A is part of the transpososome complex. DDE- recombinase A cleaves the viral DNA and the resulting 3'-OH performs a nucleophilic attack of the host DNA. The 5' flanking DNA is not resected and an intermediary structure is formed. This structure is resolved by target-primed replication leading to two copies of the viral genome (the original one and the copied one). Host ClpX and translation initiation factor IF2 play an essential transpososome-remodeling role by releasing the block between transposition and DNA replication. Successive rounds of replicative transposition can lead up to 100 copies of the viral genome. Promotes replication and thereby lytic development by competing with repressor c (Repc) for binding to the internal activation sequence (IAS) in the enhancer/operator region. The outcome of this competition determines if the virus enters latency or starts replication. Belongs to the mulikevirus repressor c protein family%3B Contains 1 HTH Mu-type domain gene gene3252 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03253 VSVS12_03254 VSVS12_03254 VSVS12_03254 244000 244224 - Sugar fermentation stimulation protein This protein is involved in positive regulation of the metabolism of sugars%3B Belongs to the ner transcriptional regulatory family gene gene3253 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03254 VSVS12_03255 VSVS12_03255 VSVS12_03255 244407 245156 + putative HTH-type transcriptional regulator Contains 1 HTH cro/C1-type DNA-binding domain gene gene3254 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03255 VSVS12_03256 VSVS12_03256 VSVS12_03256 245439 247253 + Mitochondrial sodium/hydrogen exchanger 9B2 Electroneutral exchange of protons for Na(+) and Li(+) across the inner mitochondrial membrane. Contributes to the organellar volume homeostasis. Required for osteoclast differentiation and bone resorption activity (By similarity)%3B Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2. A. 36) family gene gene3255 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03256 VSVS12_03257 VSVS12_03257 VSVS12_03257 247713 248189 - hypothetical protein gene gene3256 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03257 VSVS12_03258 VSVS12_03258 VSVS12_03258 248621 248902 + hypothetical protein gene gene3257 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03258 VSVS12_03259 VSVS12_03259 VSVS12_03259 248946 249314 + hypothetical protein gene gene3258 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03259 VSVS12_03260 VSVS12_03260 VSVS12_03260 249361 249711 + hypothetical protein gene gene3259 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03260 VSVS12_03261 VSVS12_03261 VSVS12_03261 249848 250168 + hypothetical protein gene gene3260 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03261 VSVS12_03262 VSVS12_03262 VSVS12_03262 250217 250642 + Lactoylglutathione lyase Belongs to the glyoxalase I family%3B KEGG: zmo:ZMO0030 lactoylglutathione lyase gene gene3261 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03262 VSVS12_03263 VSVS12_03263 VSVS12_03263 250664 251149 + hypothetical protein gene gene3262 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03263 VSVS12_03264 VSVS12_03264 VSVS12_03264 251216 251593 + hypothetical protein gene gene3263 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03264 VSVS12_03265 VSVS12_03265 VSVS12_03265 251717 252058 - UPF0045 protein Belongs to the UPF0045 family gene gene3264 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03265 VSVS12_03266 VSVS12_03266 VSVS12_03266 252079 252570 - Peptidylprolyl isomerase May catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides thereby assisting the folding of proteins. May also function as a chaperone%2C playing a role in intracellular transport of proteins. May also have a protein ubiquitin ligase activity acting as an E3 ubiquitin protein ligase or as an ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on proteins%3B Belongs to the cyclophilin-type PPIase family. PPIL2 subfamily%3B Contains 1 PPIase cyclophilin-type domain%3B Contains 1 U-box domain%3B KEGG: vfi:VF_1098 peptidyl-prolyl cis-trans isomerase B (cyclophilin B) gene gene3265 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03266 VSVS12_03267 VSVS12_03267 VSVS12_03267 252732 253133 + 8-oxo-dGTP diphosphatase KEGG: ccr:CC_1346 8-oxo-dGTP diphosphatase gene gene3266 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03267 VSVS12_03268 VSVS12_03268 VSVS12_03268 253221 253628 - hypothetical protein gene gene3267 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03268 VSVS12_03269 VSVS12_03269 VSVS12_03269 253797 254150 + hypothetical protein gene gene3268 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03269 VSVS12_03270 VSVS12_03270 VSVS12_03270 254299 255021 + hypothetical protein gene gene3269 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03270 VSVS12_03271 VSVS12_03271 VSVS12_03271 255014 255478 + hypothetical protein gene gene3270 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03271 VSVS12_03272 VSVS12_03272 VSVS12_03272 255553 256197 - 1-acylglycerol-3-phosphate O-acyltransferase KEGG: noc:Noc_1727 1-acyl-sn-glycerol-3-phosphate acyltransferase gene gene3271 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03272 VSVS12_03273 VSVS12_03273 VSVS12_03273 256207 257139 - Phosphatidate cytidylyltransferase Belongs to the CDS family%3B KEGG: vch:VC1936 phosphatidate cytidylyltransferase gene gene3272 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03273 VSVS12_03274 VSVS12_03274 VSVS12_03274 257132 257857 - CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase KEGG: ret:RHE_PB00101 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase gene gene3273 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03274 VSVS12_03275 VSVS12_03275 VSVS12_03275 258221 258709 + hypothetical protein gene gene3274 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03275 VSVS12_03276 VSVS12_03276 VSVS12_03276 258775 259236 + hypothetical protein gene gene3275 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03276 VSVS12_03277 VSVS12_03277 VSVS12_03277 259233 259622 + hypothetical protein gene gene3276 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03277 VSVS12_03278 VSVS12_03278 VSVS12_03278 259632 259973 + hypothetical protein gene gene3277 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03278 VSVS12_03279 VSVS12_03279 VSVS12_03279 259970 260482 + hypothetical protein gene gene3278 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03279 VSVS12_03280 VSVS12_03280 VSVS12_03280 260504 260938 + hypothetical protein gene gene3279 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03280 VSVS12_03281 VSVS12_03281 VSVS12_03281 261000 262907 + hypothetical protein gene gene3280 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03281 VSVS12_03282 VSVS12_03282 VSVS12_03282 263144 263569 + hypothetical protein gene gene3281 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03282 VSVS12_03283 VSVS12_03283 VSVS12_03283 263790 264068 - hypothetical protein gene gene3282 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03283 VSVS12_03284 VSVS12_03284 VSVS12_03284 264348 266024 + hypothetical protein gene gene3283 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03284 VSVS12_03285 VSVS12_03285 VSVS12_03285 266125 266556 - uncharacterized protein gene gene3284 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03285 VSVS12_03286 VSVS12_03286 VSVS12_03286 266672 267160 - hypothetical protein gene gene3285 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03286 VSVS12_03287 VSVS12_03287 VSVS12_03287 267222 267782 - hypothetical protein gene gene3286 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03287 VSVS12_03288 VSVS12_03288 VSVS12_03288 267871 268404 + uncharacterized protein To B. subtilis YyaP gene gene3287 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03288 VSVS12_03289 VSVS12_03289 VSVS12_03289 268870 269595 + hypothetical protein gene gene3288 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03289 VSVS12_03290 VSVS12_03290 VSVS12_03290 269601 270434 + hypothetical protein gene gene3289 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03290 VSVS12_03291 VSVS12_03291 VSVS12_03291 271164 271316 + hypothetical protein gene gene3290 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03291 VSVS12_03292 VSVS12_03292 VSVS12_03292 271402 272298 - Putative HTH-type transcriptional regulator protein PtxE Contains 1 HTH lysR-type DNA-binding domain gene gene3291 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03292 VSVS12_03293 VSVS12_03293 VSVS12_03293 272802 273656 + Thiamine phosphate synthase Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP%2C and also probably that of HMP to HMP- P%3B In the N-terminal sectio%3B belongs to the ThiD family%3B In the C-terminal sectio%3B belongs to the thiaminase-2 family%3B KEGG: pgi:PG2109 thiamine-phosphate pyrophosphorylase gene gene3292 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03293 VSVS12_03294 VSVS12_03294 pgpB pgpB 273861 274616 + Phosphatidylglycerophosphatase Catalyzes the dephosphorylation of diacylglycerol diphosphate (DGPP) to phosphatidate (PA) and the subsequent dephosphorylation of PA to diacylglycerol (DAG). Also has undecaprenyl pyrophosphate phosphatase activity%2C required for the biosynthesis of the lipid carrier undecaprenyl phosphate. Can also use lysophosphatidic acid (LPA) and phosphatidylglycerophosphate as substrates. The pattern of activities varies according to subcellular location%2C PGP phosphatase activity is higher in the cytoplasmic membrane%2C whereas PA and LPA phosphatase activities are higher in the outer membrane. Activity is independent of a divalent cation ion and insensitive to inhibition by N- ethylmaleimide (By similarity)%3B Belongs to the PA-phosphatase related phosphoesterase family%3B KEGG: vpa:VPA0129 phosphatidylglycerophosphatase B gene gene3293 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03294 VSVS12_03295 VSVS12_03295 VSVS12_03295 274675 275748 - Putative two-component membrane permease complex subunit Could be part of a two-component membrane permease system responsible for amino acid transport under low pH. Involved in acidogenesis%2C biofilm formation and low-pH survival%3B Belongs to the UPF0718 family gene gene3294 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03295 VSVS12_03296 VSVS12_03296 VSVS12_03296 276172 276663 - hypothetical protein gene gene3295 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03296 VSVS12_03297 VSVS12_03297 VSVS12_03297 276780 277988 + hypothetical protein gene gene3296 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03297 VSVS12_03298 VSVS12_03298 VSVS12_03298 278734 279486 + Glycerol-3-phosphate regulon repressor Repressor of the glycerol-3-phosphate regulon. Contains 1 HTH deoR-type DNA-binding domain gene gene3297 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03298 VSVS12_03299 VSVS12_03299 VSVS12_03299 279495 279836 + putative NADH-dependent butanol dehydrogenase Belongs to the iron-containing alcohol dehydrogenase family%3B KEGG: cth:Cthe_0101 null%3B With NAD(+) or NADP(+) as acceptor gene gene3298 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03299 VSVS12_03300 VSVS12_03300 VSVS12_03300 279940 281148 + hypothetical protein gene gene3299 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03300 VSVS12_03301 VSVS12_03301 VSVS12_03301 281145 281996 + 1%2C3-propanediol dehydrogenase Belongs to the iron-containing alcohol dehydrogenase family%3B KEGG: esi:Exig_2290 null%3B With NAD(+) or NADP(+) as acceptor gene gene3300 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03301 VSVS12_03302 VSVS12_03302 fucA fucA 282035 282688 + L-fuculose-phosphate aldolase Belongs to the aldolase class II family. AraD/FucA subfamily%3B KEGG: amt:Amet_3758 L-fuculose-phosphate aldolase gene gene3301 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03302 VSVS12_03303 VSVS12_03303 VSVS12_03303 282696 284009 + Malate-2H(+)/Na(+)-lactate antiporter Couples proton uptake and Na(+) efflux to the substrate- product malate/lactate antiport%2C in an electroneutral malate- 2H(+)/Na(+)-lactate exchange. Plays a role in supporting growth to high density on malate at reduced protonmotive force. Belongs to the NhaC Na(+)/H(+) (TC 2. A. 35) antiporter family gene gene3302 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03303 VSVS12_03304 VSVS12_03304 mtnA mtnA 284019 285071 + S-methyl-5-thioribose-1-phosphate isomerase Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)%3B Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily%3B KEGG: ctc:CTC00945 methylthioribose-1-phosphate isomerase gene gene3303 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03304 VSVS12_03305 VSVS12_03305 mtnK mtnK 285078 286280 + S-methyl-5-thioribose kinase Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate%3B Belongs to the methylthioribose kinase family%3B KEGG: ctc:CTC00946 5-methylthioribose kinase gene gene3304 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03305 VSVS12_03306 VSVS12_03306 VSVS12_03306 286454 287800 + Arginine/ornithine antiporter ArcD Uptake of arginine from the medium in exchange for ornithine%3B Belongs to the NhaC Na(+)/H(+) (TC 2. A. 35) antiporter family gene gene3305 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03306 VSVS12_03307 VSVS12_03307 VSVS12_03307 288084 289292 + hypothetical protein gene gene3306 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03307 VSVS12_03308 VSVS12_03308 VSVS12_03308 289609 290088 + Ribosomal-protein-alanine N-acetyltransferase KEGG: myv:G155_08035 ribosomal-protein-alanine N-acetyltransferase gene gene3307 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03308 VSVS12_03309 VSVS12_03309 VSVS12_03309 290158 290418 + hypothetical protein gene gene3308 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03309 VSVS12_03310 VSVS12_03310 VSVS12_03310 290646 290801 + hypothetical protein gene gene3309 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03310 VSVS12_03311 VSVS12_03311 VSVS12_03311 290883 291179 + Arsenate reductase (glutaredoxin) KEGG: mfa:Mfla_1493 arsenate reductase gene gene3310 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03311 VSVS12_03312 VSVS12_03312 VSVS12_03312 291163 291735 + RNA polymerase sigma factor SigZ Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. Belongs to the sigma-70 factor family. ECF subfamily gene gene3311 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03312 VSVS12_03313 VSVS12_03313 VSVS12_03313 291815 293728 - Putative methyl-accepting chemotaxis protein YoaH Contains 1 HAMP domain%3B Contains 1 methyl-accepting transducer domain gene gene3312 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03313 VSVS12_03314 VSVS12_03314 VSVS12_03314 294139 294567 + hypothetical protein gene gene3313 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03314 VSVS12_03315 VSVS12_03315 VSVS12_03315 294627 294941 - hypothetical protein gene gene3314 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03315 VSVS12_03316 VSVS12_03316 VSVS12_03316 295082 295399 + hypothetical protein gene gene3315 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03316 VSVS12_03317 VSVS12_03317 VSVS12_03317 295551 295964 + hypothetical protein gene gene3316 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03317 VSVS12_03318 VSVS12_03318 VSVS12_03318 296066 298159 - Methyl-accepting chemotaxis protein PctA Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment%2C transduce a signal from the outside to the inside of the cell%2C and facilitate sensory adaptation through the variation of the level of methylation. Major receptor that responds to all naturally occurring L-amino acids%2C except L-Gln and L-Asp. Also involved in repellent responses to trichloroethylene (TCE)%2C chloroform and methylthiocyanate%3B Contains 1 cache domain%3B Contains 1 HAMP domain%3B Contains 1 methyl-accepting transducer domain gene gene3317 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03318 VSVS12_03319 VSVS12_03319 VSVS12_03319 298585 299211 + DNA-directed DNA polymerase Probable helicase involved in DNA repair and perhaps also replication%3B Belongs to the helicase family. DinG subfamily%3B Contains 1 exonuclease domain%3B Contains 1 helicase ATP-binding domain%3B Contains 1 helicase C-terminal domain%3B KEGG: vtu:IX91_15555 DNA polymerase III subunit epsilon gene gene3318 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03319 VSVS12_03320 VSVS12_03320 VSVS12_03320 299337 299795 + hypothetical protein gene gene3319 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03320 VSVS12_03321 VSVS12_03321 VSVS12_03321 299792 299989 + uncharacterized protein gene gene3320 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03321 VSVS12_03322 VSVS12_03322 VSVS12_03322 300044 300355 - UPF0251 protein Belongs to the UPF0251 family gene gene3321 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03322 VSVS12_03323 VSVS12_03323 VSVS12_03323 300389 300796 + hypothetical protein gene gene3322 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03323 VSVS12_03324 VSVS12_03324 VSVS12_03324 300901 301587 + Protein YiiM Contains 1 MOSC domain gene gene3323 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03324 VSVS12_03325 VSVS12_03325 VSVS12_03325 301844 302731 - putative HTH-type transcriptional regulator YwbI Contains 1 HTH lysR-type DNA-binding domain gene gene3324 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03325 VSVS12_03326 VSVS12_03326 VSVS12_03326 302766 303401 - hypothetical protein gene gene3325 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03326 VSVS12_03327 VSVS12_03327 VSVS12_03327 303455 303880 - putative HTH-type transcriptional regulator YidP Contains 1 HTH gntR-type DNA-binding domain gene gene3326 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03327 VSVS12_03328 VSVS12_03328 VSVS12_03328 304070 304816 + hypothetical protein gene gene3327 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03328 VSVS12_03329 VSVS12_03329 VSVS12_03329 304965 306356 + Multidrug resistance protein HmrM Multidrug efflux pump that functions as a Na(+)/drug antiporter. Confers resistance to norfloxacin%2C acriflavine%2C doxorubicin%2C ethidium bromide%2C tetraphenylphosphonium chloride%2C daunomycin%2C berberine and sodium deoxycholate%3B Belongs to the multi antimicrobial extrusion (MATE) (TC 2. A. 66. 1) family gene gene3328 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03329 VSVS12_03330 VSVS12_03330 speG speG 306453 306899 - Diamine N-acetyltransferase KEGG: pat:Patl_0928 diamine N-acetyltransferase gene gene3329 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03330 VSVS12_03331 VSVS12_03331 VSVS12_03331 307091 307522 + hypothetical protein gene gene3330 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03331 VSVS12_03332 VSVS12_03332 VSVS12_03332 307545 308192 - hypothetical protein gene gene3331 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03332 VSVS12_03333 VSVS12_03333 fruA fruA 308368 309771 + Protein-N(pi)-phosphohistidine--sugar phosphotransferase The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS)%2C a major carbohydrate active -transport system%2C catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in fructose transport (By similarity)%3B Contains 1 PTS EIIA type-2 domain%3B Contains 1 PTS EIIB type-2 domain%3B Contains 1 PTS EIIC type-2 domain%3B KEGG: vvy:VVA1395 PTS system%2C fructose-specific IIB component gene gene3332 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03333 VSVS12_03334 VSVS12_03334 VSVS12_03334 309857 312538 + Alpha-mannosidase May hydrolyze mannosyl-D-glycerate to mannose-6- phosphate and glycerate%3B Belongs to the glycosyl hydrolase 38 family%3B KEGG: vvy:VVA1394 alpha-mannosidase gene gene3333 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03334 VSVS12_03335 VSVS12_03335 VSVS12_03335 312562 314268 + Sucrose phosphorylase Catalyzes the reversible phosphorolysis of sucrose 6(F)- phosphate. It also acts on sucrose%2C D-fructose%2C alpha-D-glucose 1- phosphate and D-fructose 6-phosphate%3B Belongs to the sucrose phosphorylase family%3B KEGG: vtu:IX91_16210 sucrose phosphorylase gene gene3334 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03335 VSVS12_03336 VSVS12_03336 fruB fruB 314281 314883 + Protein-N(pi)-phosphohistidine--sugar phosphotransferase Involved in thermoinduction of ompC. The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS)%2C a major carbohydrate active -transport system%2C catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane%3B Contains 1 PTS EIIA type-2 domain%3B Contains 1 PTS EIIB type-2 domain%3B Contains 1 PTS EIIC type-2 domain%3B KEGG: vvy:VVA1392 PTS system%2C fructose-specific IIA component gene gene3335 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03336 VSVS12_03337 VSVS12_03337 manA manA 315147 316340 + Mannose-6-phosphate isomerase Involved in the conversion of glucose to GDP-L-fucose%2C which can be converted to L-fucose%2C a capsular polysaccharide. Belongs to the mannose-6-phosphate isomerase type 1 family%3B KEGG: vvy:VVA1390 mannose-6-phosphate isomerase gene gene3336 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03337 VSVS12_03338 VSVS12_03338 VSVS12_03338 316474 317610 - NADPH-dependent butanol dehydrogenase This enzyme has activity using butanol and ethanol as substrates. Belongs to the iron-containing alcohol dehydrogenase family%3B KEGG: ckl:CKL_0543 null%3B With NAD(+) or NADP(+) as acceptor gene gene3337 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03338 VSVS12_03339 VSVS12_03339 VSVS12_03339 317870 318712 - hypothetical protein gene gene3338 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03339 VSVS12_03340 VSVS12_03340 VSVS12_03340 318803 319126 - hypothetical protein gene gene3339 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03340 VSVS12_03341 VSVS12_03341 pgpC pgpC 319107 319751 - Phosphatidylglycerophosphatase KEGG: bvi:Bcep1808_2258 phosphatidylglycerophosphatase C gene gene3340 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03341 VSVS12_03342 VSVS12_03342 VSVS12_03342 319748 320092 - hypothetical protein gene gene3341 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03342 VSVS12_03343 VSVS12_03343 nhoA nhoA 320204 321040 - N-hydroxyarylamine O-acetyltransferase Belongs to the arylamine N-acetyltransferase family%3B KEGG: rme:Rmet_4744 N-hydroxyarylamine O-acetyltransferase gene gene3342 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03343 VSVS12_03344 VSVS12_03344 VSVS12_03344 321050 321598 - hypothetical protein gene gene3343 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03344 VSVS12_03345 VSVS12_03345 VSVS12_03345 321788 323491 - Putative uncharacterized protein YddK Contains 9 LRR (leucine-rich) repeats gene gene3344 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03345 VSVS12_03346 VSVS12_03346 VSVS12_03346 323655 324176 - hypothetical protein gene gene3345 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03346 VSVS12_03347 VSVS12_03347 VSVS12_03347 324306 324917 + hypothetical protein gene gene3346 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03347 VSVS12_03348 VSVS12_03348 lipL lipL 324972 325682 + Octanoyl-[GcvH]:protein N-octanoyltransferase Contains 1 BPL/LPL catalytic domain%3B KEGG: gtn:GTNG_3360 octanoyl-(GcvH):protein N-octanoyltransferase gene gene3347 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03348 VSVS12_03349 VSVS12_03349 proV proV 325763 327001 - Quaternary-amine-transporting ATPase Involved in a multicomponent binding-protein-dependent transport system for glycine betaine/L-proline. Belongs to the ABC transporter superfamily%3B Contains 1 ABC transporter domain%3B Contains 2 CBS domains%3B KEGG: vha:VIBHAR_06564 glycine betaine/proline transport system ATP-binding protein gene gene3348 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03349 VSVS12_03350 VSVS12_03350 VSVS12_03350 326994 327893 - Bicarbonate transport system permease protein CmpB Part of the ABC transporter complex CmpABCD involved in bicarbonate transport. Probably responsible for the translocation of the substrate across the membrane (Probable)%3B Belongs to the binding-protein-dependent transport system permease family%3B Contains 1 ABC transmembrane type-1 domain gene gene3349 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03350 VSVS12_03351 VSVS12_03351 VSVS12_03351 327990 328991 - hypothetical protein gene gene3350 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03351 VSVS12_03352 VSVS12_03352 VSVS12_03352 329216 330967 - HTH-type transcriptional regulator SgrR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain%3B Contains 1 HTH marR-type DNA-binding domain gene gene3351 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03352 VSVS12_03353 VSVS12_03353 VSVS12_03353 331254 331871 - putative membrane protein Belongs to the DedA family gene gene3352 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03353 VSVS12_03354 VSVS12_03354 VSVS12_03354 332359 333675 + Arginine/agmatine antiporter Major component of the acid-resistance (AR) system allowing enteric pathogens to survive the acidic environment in the stomach. Exchanges extracellular arginine for its intracellular decarboxylation product agmatine (Agm) thereby expelling intracellular protons%3B Belongs to the amino acid-polyamine-organocation (APC) superfamily gene gene3353 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03354 VSVS12_03355 VSVS12_03355 adiA adiA 333739 336030 + Arginine decarboxylase ADC can be found in two forms: biodegradative and biosynthetic. The biodegradative form may play a role in regulating pH by consuming proteins. Belongs to the Orn/Lys/Arg decarboxylase class-I family%3B KEGG: xdo:XDD1_2275 arginine decarboxylase gene gene3354 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03355 VSVS12_03356 VSVS12_03356 VSVS12_03356 336208 336729 - Chromate reductase Involved in the protection against chromate toxicity. Catalyzes the transfer of three electrons to Cr(6+) producing Cr(3+) and one electron to molecular oxygen without producing the toxic Cr(5+) species and only producing a minimal amount of reactive oxygen species (ROS) (By similarity)%3B Belongs to the SsuE family gene gene3355 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03356 VSVS12_03357 VSVS12_03357 VSVS12_03357 336865 337767 + putative HTH-type transcriptional regulator YhjC Contains 1 HTH lysR-type DNA-binding domain gene gene3356 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03357 VSVS12_03358 VSVS12_03358 VSVS12_03358 337900 339108 - Putative nucleoside permease NupX Belongs to the concentrative nucleoside transporter (CNT) (TC 2. A. 41) family gene gene3357 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03358 VSVS12_03359 VSVS12_03359 dbpA dbpA 339717 341270 + RNA helicase DEAD-box RNA helicase possibly involved in RNA degradation. Unwinds dsRNA in both 5'- and 3'-directions%2C has RNA- dependent ATPase activity%3B Belongs to the DEAD box helicase family. CshA subfamily%3B Contains 1 helicase ATP-binding domain%3B Contains 1 helicase C-terminal domain%3B KEGG: kko:Kkor_0617 ATP-independent RNA helicase DbpA gene gene3358 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03359 VSVS12_03360 VSVS12_03360 VSVS12_03360 342063 343652 + putative transporter Belongs to the amino acid-polyamine-organocation (APC) superfamily gene gene3359 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03360 VSVS12_03361 VSVS12_03361 VSVS12_03361 343667 344626 + Glutaminase Belongs to the glutaminase family%3B KEGG: bth:BT_2571 glutaminase gene gene3360 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03361 VSVS12_03362 VSVS12_03362 VSVS12_03362 344642 346036 + Glutamate decarboxylase Converts internalized glutamate to GABA and increases the internal pH. Involved in glutamate-dependent acid resistance in gastric fluid. Belongs to the group II decarboxylase family%3B KEGG: dhy:DESAM_22313 glutamate decarboxylase gene gene3361 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03362 VSVS12_03363 VSVS12_03363 VSVS12_03363 346150 346764 + UPF0126 membrane protein Belongs to the UPF0126 family gene gene3362 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03363 VSVS12_03364 VSVS12_03364 VSVS12_03364 347086 347628 + hypothetical protein gene gene3363 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03364 VSVS12_03365 VSVS12_03365 VSVS12_03365 347670 347888 + hypothetical protein gene gene3364 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03365 VSVS12_03366 VSVS12_03366 VSVS12_03366 347921 348841 - putative transporter YoaV Belongs to the EamA transporter family%3B Contains 2 EamA domains gene gene3365 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03366 VSVS12_03367 VSVS12_03367 VSVS12_03367 349078 349662 + UPF0098 protein Belongs to the UPF0098 family gene gene3366 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03367 VSVS12_03368 VSVS12_03368 VSVS12_03368 349962 350387 + hypothetical protein gene gene3367 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03368 VSVS12_03369 VSVS12_03369 VSVS12_03369 350384 352717 + hypothetical protein gene gene3368 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03369 VSVS12_03370 VSVS12_03370 VSVS12_03370 352801 353019 - putative HTH-type transcriptional regulator YozG Contains 1 HTH cro/C1-type DNA-binding domain gene gene3369 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03370 VSVS12_03371 VSVS12_03371 VSVS12_03371 353029 353577 - hypothetical protein gene gene3370 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03371 VSVS12_03372 VSVS12_03372 VSVS12_03372 353918 354358 + hypothetical protein gene gene3371 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03372 VSVS12_03373 VSVS12_03373 VSVS12_03373 354701 355018 + G-box-binding factor gene gene3372 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03373 VSVS12_03374 VSVS12_03374 VSVS12_03374 355122 356459 - UPF0597 protein Belongs to the UPF0597 family gene gene3373 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03374 VSVS12_03375 VSVS12_03375 VSVS12_03375 356774 358717 - putative signaling protein Contains 1 EAL domain%3B Contains 1 GGDEF domain%3B Contains 1 MHYT domain%3B KEGG: vfi:VF_A0057 null%3B Phosphotransferases with a nitrogenous group as acceptor gene gene3374 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03375 VSVS12_03376 VSVS12_03376 VSVS12_03376 358720 359205 - hypothetical protein gene gene3375 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03376 VSVS12_03377 VSVS12_03377 VSVS12_03377 359279 360415 - hypothetical protein gene gene3376 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03377 VSVS12_03378 VSVS12_03378 VSVS12_03378 360485 361414 - hypothetical protein gene gene3377 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03378 VSVS12_03379 VSVS12_03379 VSVS12_03379 361597 362481 - Transposon Tn10 TetD protein Contains 1 HTH araC/xylS-type DNA-binding domain gene gene3378 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03379 VSVS12_03380 VSVS12_03380 lysN lysN 362664 363815 + 2-aminoadipate transaminase Catalyzes the transfer of an amino group between 2- oxoadipate (2-OA) and glutamate (Glu) to yield alpha-aminodipate (AAA). It can also transaminate glutamate%2C leucine%2C and aromatic amino acids. It also contributes in the biosynthesis of other amino acids such as leucine%3B Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family%3B KEGG: nno:NONO_c11340 2-aminoadipate transaminase%3B Transaminases gene gene3379 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03380 VSVS12_03381 VSVS12_03381 VSVS12_03381 363885 364448 - hypothetical protein gene gene3380 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03381 VSVS12_03382 VSVS12_03382 VSVS12_03382 364693 365355 - Phosphoserine phosphatase KEGG: nno:NONO_c06800 putative phosphoserine phosphatase / 1-acylglycerol-3-phosphate O-acyltransferase gene gene3381 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03382 VSVS12_03383 VSVS12_03383 VSVS12_03383 365358 366377 - Cytochrome c bioproteinis ATP-binding export protein CcmA Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochrome%3B once thought to export heme%2C this seems not to be the case%2C but its exact role is uncertain. Responsible for energy coupling to the transport system%3B Belongs to the ABC transporter superfamily. CcmA exporter (TC 3. A. 1. 107) family%3B Contains 1 ABC transporter domain gene gene3382 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03383 VSVS12_03384 VSVS12_03384 VSVS12_03384 366377 367162 - hypothetical protein gene gene3383 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03384 VSVS12_03385 VSVS12_03385 VSVS12_03385 367149 368060 - Thiamine transport system permease protein ThiP Part of the ABC transporter complex ThiBPQ involved in thiamine import. Probably responsible for the translocation of the substrate across the membrane (By similarity)%3B Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily%3B Contains 2 ABC transmembrane type-1 domains gene gene3384 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03385 VSVS12_03386 VSVS12_03386 VSVS12_03386 368057 368881 - hypothetical protein gene gene3385 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03386 VSVS12_03387 VSVS12_03387 VSVS12_03387 368918 369994 - hypothetical protein gene gene3386 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03387 VSVS12_03388 VSVS12_03388 VSVS12_03388 370232 370948 + Putative transcriptional regulator of 2-aminoethylphosphonate degradation operons Contains 1 HTH gntR-type DNA-binding domain gene gene3387 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03388 VSVS12_03389 VSVS12_03389 VSVS12_03389 371121 371540 + hypothetical protein gene gene3388 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03389 VSVS12_03390 VSVS12_03390 VSVS12_03390 371664 371942 - hypothetical protein gene gene3389 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03390 VSVS12_03391 VSVS12_03391 VSVS12_03391 371944 373368 - hypothetical protein gene gene3390 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03391 VSVS12_03392 VSVS12_03392 VSVS12_03392 373439 374356 - putative HTH-type transcriptional regulator LtrA Contains 1 HTH lysR-type DNA-binding domain gene gene3391 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03392 VSVS12_03393 VSVS12_03393 VSVS12_03393 374591 375853 + hypothetical protein gene gene3392 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03393 VSVS12_03394 VSVS12_03394 VSVS12_03394 375853 376032 + hypothetical protein gene gene3393 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03394 VSVS12_03395 VSVS12_03395 pldA pldA 376269 377060 + Phospholipase A(1) Hydrolysis of phosphatidylcholine with phospholipase A2 (EC 3. 1. 1. 4) and phospholipase A1 (EC 3. 1. 1. 32) activities%3B Belongs to the phospholipase A1 family%3B KEGG: vha:VIBHAR_02841 phospholipase A1 gene gene3394 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03395 VSVS12_03396 VSVS12_03396 VSVS12_03396 377164 378705 - putative MFS-type transporter YvkA Belongs to the major facilitator superfamily. TCR/Tet family gene gene3395 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03396 VSVS12_03397 VSVS12_03397 VSVS12_03397 378707 379744 - Multidrug resistance protein MdtN Could be involved in resistance to puromycin%2C acriflavine and tetraphenylarsonium chloride%3B Belongs to the membrane fusion protein (MFP) (TC 8. A. 1) family gene gene3396 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03397 VSVS12_03398 VSVS12_03398 VSVS12_03398 380177 380560 + hypothetical protein gene gene3397 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03398 VSVS12_03399 VSVS12_03399 VSVS12_03399 380780 381706 + Protein PagO Belongs to the EamA transporter family%3B Contains 2 EamA domains gene gene3398 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03399 VSVS12_03400 VSVS12_03400 VSVS12_03400 381792 382661 - HTH-type transcriptional activator RhaS Activates expression of the rhaBAD and rhaT operons%3B Contains 2 HTH araC/xylS-type DNA-binding domains gene gene3399 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03400 VSVS12_03401 VSVS12_03401 VSVS12_03401 382752 382970 - hypothetical protein gene gene3400 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03401 VSVS12_03402 VSVS12_03402 VSVS12_03402 382973 384271 - hypothetical protein gene gene3401 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03402 VSVS12_03403 VSVS12_03403 VSVS12_03403 384296 384607 - hypothetical protein gene gene3402 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03403 VSVS12_03404 VSVS12_03404 VSVS12_03404 384607 386157 - 3-chloro-4-hydroxyphenylacetate reductive dehalogenase Catalyzes the reductive dechlorination of C1-OHPA to 4- hydroxyphenylacetate with reduced methyl viologen as the electron donor. Contains 2 4Fe-4S ferredoxin-type domains gene gene3403 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03404 VSVS12_03405 VSVS12_03405 VSVS12_03405 386141 387247 - hypothetical protein gene gene3404 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03405 VSVS12_03406 VSVS12_03406 VSVS12_03406 387501 388376 - putative HTH-type transcriptional regulator YbfI Contains 1 HTH araC/xylS-type DNA-binding domain gene gene3405 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03406 VSVS12_03407 VSVS12_03407 VSVS12_03407 388443 389036 - Cysteine/O-acetylserine efflux protein Exporter of O-acetylserine (OAS) and cysteine%3B Belongs to the rht family gene gene3406 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03407 VSVS12_03408 VSVS12_03408 VSVS12_03408 389385 390965 + putative ABC transporter ATP-binding protein Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily%3B Contains 2 ABC transporter domains gene gene3407 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03408 VSVS12_03409 VSVS12_03409 VSVS12_03409 391106 391549 + DNA-binding protein Binds double-stranded DNA (dsDNA) gene gene3408 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03409 VSVS12_03410 VSVS12_03410 VSVS12_03410 391944 393170 + Sodium/glutamate symport carrier protein Catalyzes the sodium-dependent uptake of extracellular glutamate%3B Belongs to the GltS symporter family gene gene3409 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03410 VSVS12_03411 VSVS12_03411 VSVS12_03411 393511 395241 + Histidine kinase Cyclic-di-GMP is a second messenger which controls cell surface-associated traits in bacteria. Contains 1 GGDEF domain%3B KEGG: gme:Gmet_2694 two-component system%2C OmpR family%2C phosphate regulon sensor histidine kinase PhoR gene gene3410 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03411 VSVS12_03412 VSVS12_03412 VSVS12_03412 395398 395787 + hypothetical protein gene gene3411 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03412 VSVS12_03413 VSVS12_03413 VSVS12_03413 396098 396622 + hypothetical protein gene gene3412 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03413 VSVS12_03414 VSVS12_03414 VSVS12_03414 396859 397233 + hypothetical protein gene gene3413 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03414 VSVS12_03415 VSVS12_03415 VSVS12_03415 397418 399415 - Lactocepin Mediates the entry of Listeria monocytogenes into cells%3B Contains 15 LRR (leucine-rich) repeats%3B Contains 1 LRRCT domain%3B Contains 1 LRRNT domain%3B KEGG: pta:HPL003_05920 lactocepin gene gene3414 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03415 VSVS12_03416 VSVS12_03416 VSVS12_03416 399575 400414 - hypothetical protein gene gene3415 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03416 VSVS12_03417 VSVS12_03417 VSVS12_03417 400537 401064 - Diamine N-acetyltransferase Involved in the protection against polyamine toxicity by regulating their concentration. Catalyzes the transfer of an acetyl group from acetyl coenzyme A (AcCoA) to the primary amino groups of spermidine to yield N(1)- and N(8)-acetylspermidine%3B Belongs to the acetyltransferase family%3B Contains 1 N-acetyltransferase domain%3B KEGG: van:VAA_01303 diamine N-acetyltransferase gene gene3416 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03417 VSVS12_03418 VSVS12_03418 VSVS12_03418 401339 402775 + Coniferyl-aldehyde dehydrogenase Belongs to the aldehyde dehydrogenase family%3B KEGG: vtu:IX91_22150 coniferyl-aldehyde dehydrogenase gene gene3417 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03418 VSVS12_03419 VSVS12_03419 VSVS12_03419 402868 403764 - Protein translocase subunit SecF Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA%3B Belongs to the SecD/SecF family. SecF subfamily gene gene3418 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03419 VSVS12_03420 VSVS12_03420 VSVS12_03420 403767 405581 - Protein translocase subunit Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA%3B Belongs to the SecD/SecF family. SecD subfamily gene gene3419 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03420 VSVS12_03421 VSVS12_03421 VSVS12_03421 405790 406305 - hypothetical protein gene gene3420 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03421 VSVS12_03422 VSVS12_03422 VSVS12_03422 406613 408460 - hypothetical protein gene gene3421 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03422 VSVS12_03423 VSVS12_03423 VSVS12_03423 408744 409658 - Non-specific serine/threonine protein kinase Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family%3B Contains 1 protein kinase domain%3B KEGG: vsp:VS_1622 RIO kinase 1 gene gene3422 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03423 VSVS12_03424 VSVS12_03424 malZ malZ 410239 411825 + Alpha-glucosidase Belongs to the glycosyl hydrolase 13 family%3B KEGG: kvd:KR75_26480 alpha-glucosidase gene gene3423 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03424 VSVS12_03425 VSVS12_03425 VSVS12_03425 411825 413156 + Putative sulfoquinovose importer Could be involved in sulfoquinovose import%3B Belongs to the sodium:galactoside symporter (TC 2. A. 2) family gene gene3424 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03425 VSVS12_03426 VSVS12_03426 VSVS12_03426 413493 413849 + hypothetical protein gene gene3425 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03426 VSVS12_03427 VSVS12_03427 VSVS12_03427 413952 414770 + Sugar phosphatase YbiV Catalyzes the hydrolysis of sugar phosphate to sugar and inorganic phosphate. Has a wide substrate specificity catalyzing the hydrolysis of ribose-5-phosphate%2C glucose-6-phosphate%2C fructose-1-phosphate%2C acetyl-phosphate%2C glycerol-1-phosphate%2C glycerol-2-phosphate%2C 2-deoxy-glucose-6-phosphate%2C mannose-6- phosphate and fructose-6-phosphate. Appears to have a low level of phosphotransferase activity using monophosphates as the phosphate donor%3B Belongs to the HAD-like hydrolase superfamily. Cof family. SupH subfamily gene gene3426 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03427 VSVS12_03428 VSVS12_03428 VSVS12_03428 414839 415129 - hypothetical protein gene gene3427 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03428 VSVS12_03429 VSVS12_03429 VSVS12_03429 415329 416267 - HTH-type transcriptional regulator ArgR ArgR could be a transcriptional activator of the dauBAR operon in response to the presence of L-Arg gene gene3428 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03429 VSVS12_03430 VSVS12_03430 VSVS12_03430 416416 416811 + hypothetical protein gene gene3429 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03430 VSVS12_03431 VSVS12_03431 VSVS12_03431 416983 417162 + hypothetical protein gene gene3430 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03431 VSVS12_03432 VSVS12_03432 VSVS12_03432 417223 418431 + putative MFS-type transporter YbfB Belongs to the major facilitator superfamily gene gene3431 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03432 VSVS12_03433 VSVS12_03433 VSVS12_03433 418512 419246 + hypothetical protein gene gene3432 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03433 VSVS12_03434 VSVS12_03434 VSVS12_03434 419394 419825 + Cyclic pyranopterin phosphate synthase KEGG: mtuh:I917_06110 cyclic pyranopterin phosphate synthase gene gene3433 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03434 VSVS12_03435 VSVS12_03435 VSVS12_03435 419926 420795 - hypothetical protein gene gene3434 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03435 VSVS12_03436 VSVS12_03436 VSVS12_03436 420927 422687 - uncharacterized protein Contains 1 GGDEF domain gene gene3435 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03436 VSVS12_03437 VSVS12_03437 treX treX 422883 424841 - Glycogen debranching enzyme Hydrolyzes the alpha-1%2C6-glucosidic linkages in glycogen which has first been partially depolymerized by phosphorylase. Shows only very little activity with native glycogen%3B Belongs to the glycosyl hydrolase 13 family%3B KEGG: van:VAA_02890 glycogen operon protein%3B Glycosidases%2C i. e. enzymes hydrolyzing O- and S-glycosyl compounds gene gene3436 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03437 VSVS12_03438 VSVS12_03438 VSVS12_03438 425311 426726 + 6-aminohexanoate-oligomer exohydrolase KEGG: btm:MC28_2428 6-aminohexanoate-oligomer exohydrolase gene gene3437 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03438 VSVS12_03439 VSVS12_03439 VSVS12_03439 426863 427135 + hypothetical protein gene gene3438 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03439 VSVS12_03440 VSVS12_03440 VSVS12_03440 427242 428474 - putative sugar-binding periplasmic protein Part of a binding-protein-dependent transport system for a sugar%3B Belongs to the bacterial solute-binding protein 1 family gene gene3439 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03440 VSVS12_03441 VSVS12_03441 VSVS12_03441 428477 429889 - Histidine kinase Member of a two-component regulatory system QseB/QseC. Activates the flagella regulon by activating transcription of FlhDC. May activate QseB by phosphorylation (By similarity)%3B Contains 1 HAMP domain%3B Contains 1 histidine kinase domain%3B KEGG: vch:VC2713 two-component system%2C OmpR family%2C osmolarity sensor histidine kinase EnvZ gene gene3440 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03441 VSVS12_03442 VSVS12_03442 VSVS12_03442 429912 430619 - Regulator of RpoS Regulates the turnover of the sigma S factor (RpoS) by promoting its proteolysis in exponentially growing cells. Acts by binding and delivering RpoS to the ClpXP protease. RssB is not co- degraded with RpoS%2C but is released from the complex and can initiate a new cycle of RpoS recognition and degradation%3B Belongs to the RssB family%3B Contains 1 response regulatory domain gene gene3441 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03442 VSVS12_03443 VSVS12_03443 VSVS12_03443 430819 438603 - hypothetical protein gene gene3442 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03443 VSVS12_03444 VSVS12_03444 VSVS12_03444 439002 439445 + HTH-type transcriptional activator SoxR like protein Contains 1 HTH merR-type DNA-binding domain gene gene3443 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03444 VSVS12_03445 VSVS12_03445 VSVS12_03445 439506 440381 - hypothetical protein gene gene3444 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03445 VSVS12_03446 VSVS12_03446 VSVS12_03446 440559 441443 + uncharacterized protein Probable lipid hydrolase%3B Contains 1 patatin domain gene gene3445 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03446 VSVS12_03447 VSVS12_03447 VSVS12_03447 441459 441986 - hypothetical protein gene gene3446 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03447 VSVS12_03448 VSVS12_03448 VSVS12_03448 442301 443911 + Energy-dependent translational throttle protein EttA A translation factor that gates the progression of the 70S ribosomal inititation complex (IC%2C containing tRNA(fMet) in the P site) into the translation elongation cycle by using a mechanism sensitive to the ATP/ADP ratio. Binds to the 70S ribosome E site where it modulates the state of the translating ribosome during subunit translocation (By similarity)%3B Belongs to the ABC transporter superfamily. ABCF family. Translational throttle EttA subfamily%3B Contains 2 ABC transporter domains gene gene3447 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03448 VSVS12_03449 VSVS12_03449 VSVS12_03449 444026 444541 + hypothetical protein gene gene3448 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03449 VSVS12_03450 VSVS12_03450 VSVS12_03450 444672 444791 - hypothetical protein gene gene3449 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03450 VSVS12_03451 VSVS12_03451 VSVS12_03451 444788 445996 - hypothetical protein gene gene3450 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03451 VSVS12_03452 VSVS12_03452 VSVS12_03452 446208 447305 + Protein AdrA Contains 1 GGDEF domain%3B KEGG: gfo:GFO_0149 null%3B Phosphotransferases with a nitrogenous group as acceptor gene gene3451 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03452 VSVS12_03453 VSVS12_03453 VSVS12_03453 447299 447532 + hypothetical protein gene gene3452 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03453 VSVS12_03454 VSVS12_03454 VSVS12_03454 447792 448529 + Transcriptional activator protein CzcR Member of the two-component regulatory system CzcS/CzcR involved in the control of cobalt%2C zinc and cadmium homeostasis. Contains 1 OmpR/PhoB-type DNA-binding domain%3B Contains 1 response regulatory domain gene gene3453 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03454 VSVS12_03455 VSVS12_03455 creC creC 448526 449968 + Histidine kinase Member of the two-component regulatory system CreC/CreB involved in catabolic regulation. CreC may function as a membrane- associated protein kinase that phosphorylates CreB in response to environmental signals. CreC can also phosphorylate PhoB%3B Contains 1 HAMP domain%3B Contains 1 histidine kinase domain%3B KEGG: vha:VIBHAR_06625 two-component system%2C OmpR family%2C sensor histidine kinase CreC gene gene3454 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03455 VSVS12_03456 VSVS12_03456 VSVS12_03456 450088 451497 + Inner membrane protein CreD gene gene3455 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03456 VSVS12_03457 VSVS12_03457 VSVS12_03457 451487 451936 + hypothetical protein gene gene3456 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03457 VSVS12_03458 VSVS12_03458 VSVS12_03458 452121 453299 - Rubredoxin--NAD(+) reductase One of at least two accessory proteins for anaerobic nitric oxide (NO) reductase. Reduces the rubredoxin moiety of NO reductase%3B Belongs to the FAD-dependent oxidoreductase family%3B KEGG: aby:ABAYE1067 rubredoxin-NAD+ reductase gene gene3457 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03458 VSVS12_03459 VSVS12_03459 VSVS12_03459 453314 454852 - Anaerobic nitric oxide reductase flavorubredoxin Anaerobic nitric oxide reductas%3B uses NADH to detoxify nitric oxide (NO)%2C protecting several 4Fe-4S NO-sensitive enzymes. Has at least 2 reductase partners%2C only one of which (NorW%2C flavorubredoxin reductase) has been identified. NO probably binds to the di-iron cente%3B electrons enter from the NorW at rubredoxin and are transferred sequentially to the FMN center and the di-iron center. Also able to function as an aerobic oxygen reductase%3B In the N-terminal sectio%3B belongs to the zinc metallo-hydrolase group 3 family%3B Contains 1 flavodoxin-like domain%3B Contains 1 rubredoxin-like domain gene gene3458 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03459 VSVS12_03460 VSVS12_03460 VSVS12_03460 455086 456654 + Anaerobic nitric oxide reductase transcription regulator NorR Required for the expression of anaerobic nitric oxide (NO) reductase%2C acts as a transcriptional activator for at least the norVW operon. Activation also requires sigma-54%3B Contains 1 sigma-54 factor interaction domain gene gene3459 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03460 VSVS12_03461 VSVS12_03461 VSVS12_03461 456706 457668 - hypothetical protein gene gene3460 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03461 VSVS12_03462 VSVS12_03462 VSVS12_03462 457894 458328 + hypothetical protein gene gene3461 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03462 VSVS12_03463 VSVS12_03463 VSVS12_03463 458433 458684 - hypothetical protein gene gene3462 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03463 VSVS12_03464 VSVS12_03464 VSVS12_03464 458844 459101 - hypothetical protein gene gene3463 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03464 VSVS12_03465 VSVS12_03465 VSVS12_03465 459257 460252 - hypothetical protein gene gene3464 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03465 VSVS12_03466 VSVS12_03466 VSVS12_03466 460255 461604 - Putative antitoxin YwqK Probable antitoxin component of a toxin-antitoxin (TA) module. Probably neutralizes the ability to inhibit growth of cognate toxin YwqJ. Probably does not have antitoxin activity on other toxins with the LXG toxin domain (By similarity) gene gene3465 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03466 VSVS12_03467 VSVS12_03467 VSVS12_03467 461601 462857 - hypothetical protein gene gene3466 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03467 VSVS12_03468 VSVS12_03468 VSVS12_03468 463391 464722 + Uric acid permease PucJ Uptake of uric acid%3B Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2. A. 40) subfamily gene gene3467 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03468 VSVS12_03469 VSVS12_03469 guaD guaD 464725 466104 + Guanine deaminase Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine%2C respectively. Is also able to deaminate adenosine%3B Belongs to the MTA/SAH deaminase family%3B KEGG: aur:HMPREF9243_0091 guanine deaminase gene gene3468 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03469 VSVS12_03470 VSVS12_03470 VSVS12_03470 466294 467562 + hypothetical protein gene gene3469 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03470 VSVS12_03471 VSVS12_03471 VSVS12_03471 468167 468496 + Altronate dehydratase KEGG: spl:Spea_3856 altronate dehydratase small subunit%3B overlaps another CDS with the same product name gene gene3470 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03471 VSVS12_03472 VSVS12_03472 VSVS12_03472 468496 469671 + Altronate dehydratase Catalyzes the dehydration of D-altronate%3B Belongs to the UxaA family%3B KEGG: shl:Shal_0412 altronate dehydratase large subunit%3B overlaps another CDS with the same product name gene gene3471 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03472 VSVS12_03473 VSVS12_03473 VSVS12_03473 469785 470756 + hypothetical protein gene gene3472 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03473 VSVS12_03474 VSVS12_03474 lra3 lra3 470872 472014 + L-rhamnonate dehydratase Catalyzes the ring opening of D-galactaro-1%2C4-lactone to yield 5-keto-4-deoxy-D-glucarate (KDG) via a beta-elimination reaction. This is a step in the oxidative degradation pathway of D-galacturonate%2C which allows A. tumefaciens to utilize D- galacturonate as a sole carbon source. To a lesser extent%2C can also use D-glucaro-1%2C4-lactone as substrate to produce KDG%2C but cannot use D-galactaro-1%2C5-lactone%2C D-glucaro-6%2C3-lactone and linear D-glucarate%3B Belongs to the mandelate racemase/muconate lactonizing enzyme family%3B KEGG: ant:Arnit_0012 L-rhamnonate dehydratase gene gene3473 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03474 VSVS12_03475 VSVS12_03475 VSVS12_03475 472381 472650 + uncharacterized protein Contains 1 dksA C4-type zinc finger gene gene3474 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03475 VSVS12_03476 VSVS12_03476 VSVS12_03476 472988 474364 + UPF0053 protein Belongs to the UPF0053 family%3B Contains 2 CBS domains%3B Contains 1 DUF21 domain%3B overlaps another CDS with the same product name gene gene3475 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03476 VSVS12_03477 VSVS12_03477 VSVS12_03477 474361 475377 + UPF0053 protein Belongs to the UPF0053 family%3B Contains 2 CBS domains%3B Contains 1 DUF21 domain%3B overlaps another CDS with the same product name gene gene3476 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03477 VSVS12_03478 VSVS12_03478 VSVS12_03478 475370 475486 - hypothetical protein gene gene3477 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03478 VSVS12_03479 VSVS12_03479 VSVS12_03479 475535 476332 - HTH-type transcriptional regulator NimR Negatively regulates expression of the nimT operon and its own expression. Acts by binding to the nimR-nimT intergenic region%3B Contains 1 HTH araC/xylS-type DNA-binding domain gene gene3478 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03479 VSVS12_03480 VSVS12_03480 VSVS12_03480 476432 477553 + Multidrug resistance protein Multidrug resistance pump that participates in a low energy shock adaptive response. Belongs to the major facilitator superfamily gene gene3479 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03480 VSVS12_03481 VSVS12_03481 VSVS12_03481 477728 479749 - Alkyl/aryl-sulfatase BDS1 Alkyl/aryl-sulfatase. Enables the use of SDS and 4- nitrocatechol as sulfur source%3B Belongs to the metallo-beta-lactamase superfamily%3B KEGG: vfi:VF_A0035 uncharacterized sulfatase%3B Sulfuric ester hydrolases gene gene3480 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03481 VSVS12_03482 VSVS12_03482 VSVS12_03482 479866 480756 + HTH-type transcriptional activator AmpR This protein is a positive regulator of gene expression of beta-lactamase (AmpC). Contains 1 HTH lysR-type DNA-binding domain gene gene3481 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03482 VSVS12_03483 VSVS12_03483 VSVS12_03483 481054 482016 - hypothetical protein gene gene3482 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03483 VSVS12_03484 VSVS12_03484 VSVS12_03484 482239 482487 - hypothetical protein gene gene3483 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03484 VSVS12_03485 VSVS12_03485 VSVS12_03485 482517 482726 - hypothetical protein gene gene3484 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03485 VSVS12_03486 VSVS12_03486 VSVS12_03486 482735 483832 - uncharacterized protein gene gene3485 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03486 VSVS12_03487 VSVS12_03487 VSVS12_03487 484028 484510 - hypothetical protein gene gene3486 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03487 VSVS12_03488 VSVS12_03488 VSVS12_03488 484908 485186 + UPF0345 protein Belongs to the UPF0345 family gene gene3487 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03488 VSVS12_03489 VSVS12_03489 VSVS12_03489 485478 485780 + hypothetical protein gene gene3488 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03489 VSVS12_03490 VSVS12_03490 VSVS12_03490 485777 486934 - Diguanylate cyclase Photoreceptor which exists in two forms that are reversibly interconvertible by light: the R form that absorbs maximally in the red region of the spectrum and the FR form that absorbs maximally in the far-red region. Belongs to the phytochrome family%3B Contains 1 EAL domain%3B Contains 2 GAF domains%3B Contains 2 GGDEF domains%3B KEGG: tvr:TVD_08845 two-component system%2C cell cycle response regulator gene gene3489 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03490 VSVS12_03491 VSVS12_03491 VSVS12_03491 487184 488254 - hypothetical protein gene gene3490 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03491 VSVS12_03492 VSVS12_03492 VSVS12_03492 488374 488955 - Alpha-ketoglutarate-dependent dioxygenase alkB like protein Dioxygenase that repairs alkylated DNA containing 1- methyladenine (1meA) and 3-methylcytosine (3meC) by oxidative demethylation. Has a strong preference for single-stranded DNA. Able to process alkylated 3mC within double-stranded regions via its interaction with ASCC3%2C which promotes DNA unwinding to generate single-stranded substrate needed for ALKHB3. May also act on RNA. Requires molecular oxygen%2C alpha-ketoglutarate and iron%3B Belongs to the alkB family%3B Contains 1 Fe2OG dioxygenase domain%3B With 2-oxoglutarate as one donor%2C and incorporation of one atom each of oxygen into both donors gene gene3491 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03492 VSVS12_03493 VSVS12_03493 VSVS12_03493 489177 490280 + hypothetical protein gene gene3492 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03493 VSVS12_03494 VSVS12_03494 VSVS12_03494 490249 491457 - hypothetical protein gene gene3493 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03494 VSVS12_03495 VSVS12_03495 VSVS12_03495 491574 491882 + hypothetical protein gene gene3494 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03495 VSVS12_03496 VSVS12_03496 VSVS12_03496 492150 493343 - Transposase for insertion sequence element IS1001 Involved in the transposition of the insertion sequence. Belongs to the transposase 12 family gene gene3495 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03496 VSVS12_03497 VSVS12_03497 VSVS12_03497 493490 494926 - hypothetical protein gene gene3496 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03497 VSVS12_03498 VSVS12_03498 VSVS12_03498 495171 495737 + Malate synthase Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA%3B Belongs to the malate synthase family. GlcB subfamily%3B KEGG: vsp:VS_II0324 malate synthase gene gene3497 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03498 VSVS12_03499 VSVS12_03499 VSVS12_03499 495810 496058 - hypothetical protein gene gene3498 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03499 VSVS12_03500 VSVS12_03500 VSVS12_03500 496055 496465 - hypothetical protein gene gene3499 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03500 VSVS12_03501 VSVS12_03501 VSVS12_03501 496545 497141 - Lysine exporter protein Involved in the efflux of excess of L-lysine. This is necessary to control the intracellular L-lysine level (By similarity)%3B Belongs to the LysE/ArgO transporter (TC 2. A. 75) family gene gene3500 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03501 VSVS12_03502 VSVS12_03502 VSVS12_03502 497142 497678 - hypothetical protein gene gene3501 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03502 VSVS12_03503 VSVS12_03503 VSVS12_03503 497898 498197 + hypothetical protein gene gene3502 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03503 VSVS12_03504 VSVS12_03504 VSVS12_03504 498303 498851 - hypothetical protein gene gene3503 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03504 VSVS12_03505 VSVS12_03505 VSVS12_03505 499116 499271 - hypothetical protein gene gene3504 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03505 VSVS12_03506 VSVS12_03506 rbsD rbsD 499706 500125 + D-ribose pyranase Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose%3B Belongs to the RbsD / FucU family. RbsD subfamily%3B KEGG: eclx:LI66_22675 D-ribose pyranase gene gene3505 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03506 VSVS12_03507 VSVS12_03507 yihV yihV 500158 501084 + Sulfofructose kinase Phosphorylates 6-deoxy-6-sulfo-D-fructose (SF) to 6- deoxy-6-sulfo-D-fructose 1-phosphate (SFP)%3B Belongs to the carbohydrate kinase PfkB family%3B KEGG: eco:b3883 sulfofructose kinase gene gene3506 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03507 VSVS12_03508 VSVS12_03508 VSVS12_03508 501149 502471 + L-fucose permease Transport of L-fucose into the cell. Belongs to the major facilitator superfamily. FHS transporter (TC 2. A. 1. 7) family gene gene3507 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03508 VSVS12_03509 VSVS12_03509 VSVS12_03509 502522 503526 + Monosaccharide-transporting ATPase KEGG: rsq:Rsph17025_3351 monosaccharide-transporting ATPase gene gene3508 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03509 VSVS12_03510 VSVS12_03510 VSVS12_03510 503718 504635 + Sulfofructose kinase Belongs to the carbohydrate kinase PfkB family%3B KEGG: enc:ECL_05102 sulfofructose kinase gene gene3509 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03510 VSVS12_03511 VSVS12_03511 VSVS12_03511 504653 505657 + putative HTH-type transcriptional repressor ExuR Transcriptional repressor for the exu locus which is required for galacturonate utilization%3B Contains 1 HTH lacI-type DNA-binding domain gene gene3510 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03511 VSVS12_03512 VSVS12_03512 VSVS12_03512 506151 507299 + hypothetical protein gene gene3511 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03512 VSVS12_03513 VSVS12_03513 VSVS12_03513 507703 508707 + hypothetical protein gene gene3512 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03513 VSVS12_03514 VSVS12_03514 VSVS12_03514 508821 510935 + Putative TRAP transporter large permease protein Belongs to the TRAP transporter large permease family gene gene3513 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03514 VSVS12_03515 VSVS12_03515 VSVS12_03515 511079 513103 - RNA helicase ATP-dependent RNA helicase required for ribosome biogenesis. Involved in the release of U14 snoRNA in pre-ribosomal complexes. Required for pre-rRNA cleavage at site A2 (By similarity)%3B Belongs to the DEAD box helicase family. DDX10/DBP4 subfamily%3B Contains 1 helicase ATP-binding domain%3B Contains 1 helicase C-terminal domain%3B KEGG: vvu:VV2_0147 ATP-dependent RNA helicase DeaD gene gene3514 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03515 VSVS12_03516 VSVS12_03516 VSVS12_03516 513195 513437 + hypothetical protein gene gene3515 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03516 VSVS12_03517 VSVS12_03517 VSVS12_03517 513471 515489 + Exoribonuclease II Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction%3B Belongs to the RNR ribonuclease family. RNase II subfamily%3B Contains 1 S1 motif domain%3B KEGG: eco:b1286 exoribonuclease II gene gene3516 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03517 VSVS12_03518 VSVS12_03518 VSVS12_03518 516400 516690 - hypothetical protein gene gene3517 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03518 VSVS12_03519 VSVS12_03519 VSVS12_03519 516871 517356 - putative acyl-CoA thioester hydrolase Belongs to the acyl coenzyme A hydrolase family%3B Contains 1 HotDog ACOT-type domain%3B KEGG: kbl:CKBE_00273 acyl-CoA thioesterase YciA%3B Thiolester hydrolases gene gene3518 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03519 VSVS12_03520 VSVS12_03520 VSVS12_03520 517487 517711 - hypothetical protein gene gene3519 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03520 VSVS12_03521 VSVS12_03521 VSVS12_03521 518017 519447 - Glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) Belongs to the glyceraldehyde-3-phosphate dehydrogenase family%3B KEGG: vsp:VS_II0346 glyceraldehyde 3-phosphate dehydrogenase gene gene3520 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03521 VSVS12_03522 VSVS12_03522 VSVS12_03522 520112 522805 + Hybrid signal transduction histidine kinase Acts as a receptor histidine kinase for a signal transduction pathway. This protein undergoes an ATP-dependent autophosphorylation at a conserved histidine residue in the kinase core%2C and a phosphoryl group is then transferred to a conserved aspartate residue in the receiver domain (By similarity)%3B Contains 1 histidine kinase domain%3B Contains 1 PAC (PAS-associated C-terminal) domain%3B Contains 1 response regulatory domain%3B KEGG: ava:Ava_3362 null%3B Phosphotransferases with a nitrogenous group as acceptor gene gene3521 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03522 VSVS12_03523 VSVS12_03523 VSVS12_03523 522786 523241 - dCMP deaminase Belongs to the cytidine and deoxycytidylate deaminase family%3B Contains 1 CMP/dCMP-type deaminase domain%3B KEGG: vch:VCA0840 dCMP deaminase gene gene3522 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03523 VSVS12_03524 VSVS12_03524 codA codA 523910 525187 - Cytosine deaminase Catalyzes the hydrolytic deamination of cytosine to uracil. Is involved in the pyrimidine salvage pathway%2C which allows the cell to utilize cytosine for pyrimidine nucleotide synthesis. Is also able to catalyze deamination of isoguanine%2C a mutagenic oxidation product of adenine in DNA%2C and of isocytosine. To a lesser extent%2C also catalyzes the conversion of 5- fluorocytosine (5FC) to 5-fluorouracil (5FU%3B this activity allows the formation of a cytotoxic chemotherapeutic agent from a non- cytotoxic precursor%3B Belongs to the cytosine deaminase family%3B KEGG: vvu:VV2_0789 cytosine deaminase gene gene3523 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03524 VSVS12_03525 VSVS12_03525 VSVS12_03525 525197 526435 - Cytosine permease Required for cytosine transport into the cell. Belongs to the purine-cytosine permease (2. A. 39) family gene gene3524 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03525 VSVS12_03526 VSVS12_03526 VSVS12_03526 527102 527554 + Azurin-2 Transfers electrons from cytochrome c551 to cytochrome oxidase. Contains 1 plastocyanin-like domain gene gene3525 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03526 VSVS12_03527 VSVS12_03527 ura4 ura4 527688 528716 - Dihydroorotase Belongs to the DHOase family. Type 1 subfamily%3B KEGG: vch:VCA0925 dihydroorotase gene gene3526 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03527 VSVS12_03528 VSVS12_03528 VSVS12_03528 529012 530823 + uncharacterized protein Contains 1 2Fe-2S ferredoxin-type domain%3B Contains 1 MOSC domain gene gene3527 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03528 VSVS12_03529 VSVS12_03529 VSVS12_03529 530894 531799 - putative transporter YyaM Belongs to the EamA transporter family%3B Contains 2 EamA domains gene gene3528 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03529 VSVS12_03530 VSVS12_03530 VSVS12_03530 531898 532689 + HTH-type transcriptional regulator NimR Negatively regulates expression of the nimT operon and its own expression. Acts by binding to the nimR-nimT intergenic region%3B Contains 1 HTH araC/xylS-type DNA-binding domain gene gene3529 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03530 VSVS12_03531 VSVS12_03531 VSVS12_03531 532833 534578 - Methyl-accepting chemotaxis protein PctA Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment%2C transduce a signal from the outside to the inside of the cell%2C and facilitate sensory adaptation through the variation of the level of methylation. Major receptor that responds to all naturally occurring L-amino acids%2C except L-Gln and L-Asp. Also involved in repellent responses to trichloroethylene (TCE)%2C chloroform and methylthiocyanate%3B Contains 1 cache domain%3B Contains 1 HAMP domain%3B Contains 1 methyl-accepting transducer domain gene gene3530 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03531 VSVS12_03532 VSVS12_03532 VSVS12_03532 534873 535529 - hypothetical protein gene gene3531 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03532 VSVS12_03533 VSVS12_03533 VSVS12_03533 535730 536656 - hypothetical protein gene gene3532 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03533 VSVS12_03534 VSVS12_03534 amyA amyA 536941 538296 + Alpha-amylase Belongs to the glycosyl hydrolase 13 family%3B KEGG: van:VAA_00917 alpha-amylase gene gene3533 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03534 VSVS12_03535 VSVS12_03535 VSVS12_03535 538330 538932 - hypothetical protein gene gene3534 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03535 VSVS12_03536 VSVS12_03536 VSVS12_03536 539122 540225 + hypothetical protein gene gene3535 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03536 VSVS12_03537 VSVS12_03537 VSVS12_03537 540381 540998 - hypothetical protein gene gene3536 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03537 VSVS12_03538 VSVS12_03538 VSVS12_03538 541103 541399 - hypothetical protein gene gene3537 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03538 VSVS12_03539 VSVS12_03539 VSVS12_03539 541903 542364 + hypothetical protein gene gene3538 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03539 VSVS12_03540 VSVS12_03540 VSVS12_03540 542545 543555 + Sensor protein Member of the two-component regulatory system EvgS/EvgA. Phosphorylates EvgA via a four-step phosphorelay in response to environmental signals (By similarity)%3B Contains 1 histidine kinase domain%3B Contains 1 HPt domain%3B Contains 1 response regulatory domain gene gene3539 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03540 VSVS12_03541 VSVS12_03541 VSVS12_03541 543555 543989 + hypothetical protein gene gene3540 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03541 VSVS12_03542 VSVS12_03542 VSVS12_03542 544170 545795 + ADP-dependent NAD(P)H-hydrate dehydratase Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP%2C which is converted to AMP. This allows the repair of both epimers of NAD(P)HX%2C a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity)%3B In the N-terminal sectio%3B belongs to the NnrE/AIBP family%3B In the C-terminal sectio%3B belongs to the NnrD/CARKD family%3B Contains 1 YjeF C-terminal domain%3B Contains 1 YjeF N-terminal domain%3B KEGG: mec:Q7C_1666 ADP-dependent NAD(P)H-hydrate dehydratase gene gene3541 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03542 VSVS12_03543 VSVS12_03543 guaC guaC 546231 547274 + GMP reductase Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase%2C nucleoside and nucleotide derivatives of G to A nucleotides%2C and in maintaining the intracellular balance of A and G nucleotides%3B Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily%3B KEGG: eco:b0104 GMP reductase gene gene3542 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03543 VSVS12_03544 VSVS12_03544 VSVS12_03544 547525 549132 + Histidine kinase Member of the two-component regulatory system CitT/CitS. Functions probably as a membrane-associated protein kinase that phosphorylates CitT in response to environmental citrate or Mg(2+)-citrate complex (By similarity)%3B Contains 1 histidine kinase domain%3B Contains 1 PAS (PER-ARNT-SIM) domain%3B KEGG: ctc:CTC01524 two-component system%2C CitB family%2C sensor kinase gene gene3543 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03544 VSVS12_03545 VSVS12_03545 VSVS12_03545 549123 549827 + Transcriptional regulatory protein CitB Member of the two-component regulatory system CitA/CitB essential for expression of citrate-specific fermentation genes. Phosphorylated CitB binds to two sites in the citS-citC intergenic region where it probably activates transcription of both genes%3B Contains 1 response regulatory domain gene gene3544 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03545 VSVS12_03546 VSVS12_03546 VSVS12_03546 549904 551427 - putative 52.8 kDa protein in TAR-I ttuC' 3'region gene gene3545 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03546 VSVS12_03547 VSVS12_03547 VSVS12_03547 551440 551934 - hypothetical protein gene gene3546 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03547 VSVS12_03548 VSVS12_03548 VSVS12_03548 552126 553097 - hypothetical protein gene gene3547 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03548 VSVS12_03549 VSVS12_03549 VSVS12_03549 553295 554446 - hypothetical protein gene gene3548 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03549 VSVS12_03550 VSVS12_03550 VSVS12_03550 554557 555771 - hypothetical protein gene gene3549 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03550 VSVS12_03551 VSVS12_03551 VSVS12_03551 556366 557112 + 3-oxoacyl-[acyl-carrier-protein] reductase Involved in the degradation of pyridoxine or pyridoxamine (free%2C phosphate-unbound%2C forms of vitamin B6). Oxidizes pyridoxal to 4-pyridoxolactone%2C but does not have activity toward pyridoxal 5'-phosphate%2C pyridoxine%2C pyridoxamine%2C pyridoxamine 5'-phosphate%2C 4-phthalaldehyde%2C 2-nitrobenzaldehyde%2C pyridine%2C formaldehyde%2C 2-carboxybenzaldehyde or sugars%3B Belongs to the short-chain dehydrogenases/reductases (SDR) family%3B KEGG: vej:VEJY3_19291 3-oxoacyl-(acyl-carrier protein) reductase gene gene3550 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03551 VSVS12_03552 VSVS12_03552 VSVS12_03552 557239 558627 - Protein I'm not dead yet Cation-independent electroneutral transporter (not associated with membrane depolarization) of a variety of tricarboxylic and dicarboxylic acid-cycle intermediates. There is also small%2C but detectable%2C transport of monocarboxylics. Transport is through the epithelium of the gut and across the plasma membranes of organs involved in intermediary metabolism and storage. Affinity for substrates is citrate > succinate > pyruvate. Fumarate%2C a-ketoglutarate%2C and glutarate are also transported%2C but not lactate. Transport mechanism that is not coupled to Na(+)%2C K(+)%2C or Cl(-). Function is shown in Xenopus oocytes and human retinal pigment epithelial (HRPE) cell lines%3B Belongs to the SLC13A/DASS transporter (TC 2. A. 47) family. NADC subfamily gene gene3551 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03552 VSVS12_03553 VSVS12_03553 VSVS12_03553 559152 561035 + uncharacterized protein Contains 2 CBS domains gene gene3552 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03553 VSVS12_03554 VSVS12_03554 VSVS12_03554 561032 561772 + DNA-directed DNA polymerase KEGG: vpa:VP1724 DNA polymerase III subunit epsilon gene gene3553 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03554 VSVS12_03555 VSVS12_03555 VSVS12_03555 561968 563632 + Glycine betaine transporter OpuD High-affinity uptake of glycine betaine. Does not mediate either carnitine or choline uptake%3B Belongs to the BCCT transporter (TC 2. A. 15) family gene gene3554 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03555 VSVS12_03556 VSVS12_03556 VSVS12_03556 564251 566605 - Histidine kinase Cytokinins (CK) receptor related to bacterial two- component regulators. Functions as a histidine kinase and transmits the stress signal to a downstream MAPK cascade. This protein undergoes an ATP-dependent autophosphorylation at a conserved histidine residue in the kinase core%2C and a phosphoryl group is then transferred to a conserved aspartate residue in the receiver domain. In the presence of cytokinin%2C feed phosphate to phosphorelay-integrating histidine phosphotransfer protein (HPt) and activates subsequent cascade. Involved in meristems establishment in seedlings. Redundant negative regulator of drought and salt stress responses and abscisic acid (ABA) signaling. Together with AHK3%2C plays a negative regulatory role in cold stress signaling via inhibition of ABA response%2C occurring independently of the cold acclimation pathway. Redundant positive regulator of cytokinin signaling that regulates many development process including seed germination%2C cell division%2C seed size%2C chlorophyll retention during leaf senescence%2C root repression and shoot promotion. Involved in alkamides (e. g. N-isobutyl decanamide) and N-acylethanolamides (NAE) signaling that control meristematic activity and differentiation processes during plant development. Contributes to vascular bundle formation and secondary growth in a cytokinin-dependent manner%2C probably by promoting the maintenance of mitotic activity and/or identity of procambial cells. Together with AHK4%2C required for growth and reproduction promotion stimulated by the endophytic fungus Piriformospora indica in a trans-zeatin-dependent manner. Required by the cytokinin-dependent flower development regulation pathway%3B Contains 1 CHASE domain%3B Contains 1 histidine kinase domain%3B Contains 2 response regulatory domains gene gene3555 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03556 VSVS12_03557 VSVS12_03557 VSVS12_03557 566655 568142 - hypothetical protein gene gene3556 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03557 VSVS12_03558 VSVS12_03558 VSVS12_03558 568465 569097 + hypothetical protein gene gene3557 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03558 VSVS12_03559 VSVS12_03559 VSVS12_03559 569173 570882 + Proteases secretion ATP-binding protein PrtD Involved in the secretion of proteases A%2C B%2C C and G. Belongs to the ABC transporter superfamily%3B Contains 1 ABC transmembrane type-1 domain%3B Contains 1 ABC transporter domain gene gene3558 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03559 VSVS12_03560 VSVS12_03560 VSVS12_03560 570892 572217 + Proteases secretion protein PrtE Involved in the secretion of proteases A%2C B%2C C and G. Belongs to the membrane fusion protein (MFP) (TC 8. A. 1) family gene gene3559 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03560 VSVS12_03561 VSVS12_03561 VSVS12_03561 572217 572471 + hypothetical protein gene gene3560 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03561 VSVS12_03562 VSVS12_03562 VSVS12_03562 572598 577133 - Bifunctional hemolysin/adenylate cyclase This adenylate cyclase belongs to a special class of bacterial toxin. It causes whooping cough by acting on mammalian cells by elevating cAMP-concentration and thus disrupts normal cell function. In the N-terminal sectio%3B belongs to the adenylyl cyclase class-2 family%3B In the C-terminal sectio%3B belongs to the RTX prokaryotic toxin family%3B Contains 17 hemolysin-type calcium-binding repeats gene gene3561 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03562 VSVS12_03563 VSVS12_03563 VSVS12_03563 577272 578294 - hypothetical protein gene gene3562 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03563 VSVS12_03564 VSVS12_03564 VSVS12_03564 578490 579743 + Chemotaxis protein CheY like protein Involved in the transmission of sensory signals from the chemoreceptors to the flagellar motors. CheY seems to regulate the clockwise (CW) rotation (By similarity)%3B Contains 1 response regulatory domain gene gene3563 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03564 VSVS12_03565 VSVS12_03565 VSVS12_03565 579695 580027 + hypothetical protein gene gene3564 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03565 VSVS12_03566 VSVS12_03566 gmpP gmpP 580036 581157 + Mannose-1-phosphate guanylyltransferase Involved in the assembly of a N-linked pentasaccharide that decorates the S-layer glycoprotein and flagellins. Involved in the biosynthesis of the hexuronic acid found at position 3 of the pentasaccharide%3B Belongs to the UDPGP type 2 family%3B KEGG: vsa:VSAL_II0327 mannose-1-phosphate guanylyltransferase gene gene3565 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03566 VSVS12_03567 VSVS12_03567 rsbW rsbW 581178 581657 + Non-specific serine/threonine protein kinase KEGG: vsa:VSAL_II0326 serine/threonine-protein kinase RsbW gene gene3566 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03567 VSVS12_03568 VSVS12_03568 bcsA bcsA 581707 583566 + Cellulose synthase (UDP-forming) In the N-terminal sectio%3B belongs to the glycosyltransferase 2 family%3B In the C-terminal sectio%3B belongs to the AcsB/BcsB family%3B Contains 1 PilZ domain%3B KEGG: pgb:H744_2c1635 cellulose synthase (UDP-forming) gene gene3567 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03568 VSVS12_03569 VSVS12_03569 VSVS12_03569 583556 584875 + hypothetical protein gene gene3568 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03569 VSVS12_03570 VSVS12_03570 VSVS12_03570 584896 586296 + hypothetical protein gene gene3569 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03570 VSVS12_03571 VSVS12_03571 VSVS12_03571 586308 587690 + hypothetical protein gene gene3570 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03571 VSVS12_03572 VSVS12_03572 VSVS12_03572 587687 588685 + hypothetical protein gene gene3571 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03572 VSVS12_03573 VSVS12_03573 exoK exoK 588773 589567 + Beta-glucanase Belongs to the glycosyl hydrolase 16 family%3B Contains 1 dockerin domain%3B Contains 1 GH16 (glycosyl hydrolase family 16) domain%3B KEGG: mor:MOC_5281 endo-1%2C3-1%2C4-beta-glycanase ExoK%3B Glycosidases%2C i. e. enzymes hydrolyzing O- and S-glycosyl compounds gene gene3572 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03573 VSVS12_03574 VSVS12_03574 VSVS12_03574 589706 590986 + hypothetical protein gene gene3573 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03574 VSVS12_03575 VSVS12_03575 VSVS12_03575 591097 591297 - hypothetical protein gene gene3574 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03575 VSVS12_03576 VSVS12_03576 VSVS12_03576 591484 593097 - hypothetical protein gene gene3575 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03576 VSVS12_03577 VSVS12_03577 VSVS12_03577 593305 594198 - hypothetical protein gene gene3576 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03577 VSVS12_03578 VSVS12_03578 VSVS12_03578 594436 595314 - putative HTH-type transcriptional regulator in ibpB-leuC intergenic region Contains 1 HTH lysR-type DNA-binding domain gene gene3577 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03578 VSVS12_03579 VSVS12_03579 VSVS12_03579 595451 596032 + hypothetical protein gene gene3578 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03579 VSVS12_03580 VSVS12_03580 aacS aacS 596061 598142 - Acetoacetate--CoA ligase Catalyzes the conversion of acetate into acetyl-CoA (AcCoA)%2C an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction%2C AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction%2C it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA%2C forming the product AcCoA%3B Belongs to the ATP-dependent AMP-binding enzyme family%3B KEGG: vpa:VPA1158 acetoacetyl-CoA synthetase gene gene3579 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03580 VSVS12_03581 VSVS12_03581 phhA phhA 598468 599262 + Phenylalanine 4-monooxygenase Belongs to the biopterin-dependent aromatic amino acid hydroxylase family%3B KEGG: vha:VIBHAR_05421 phenylalanine-4-hydroxylase gene gene3580 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03581 VSVS12_03582 VSVS12_03582 pcbD pcbD 599252 599614 + 4a-hydroxytetrahydrobiopterin dehydratase Belongs to the pterin-4-alpha-carbinolamine dehydratase family%3B KEGG: vch:VCA0827 4a-hydroxytetrahydrobiopterin dehydratase gene gene3581 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03582 VSVS12_03583 VSVS12_03583 VSVS12_03583 599815 600483 + hypothetical protein gene gene3582 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03583 VSVS12_03584 VSVS12_03584 VSVS12_03584 600637 601320 + Pyrimidine 5'-nucleotidase Nucleotidase that shows high phosphatase activity toward non-canonical pyrimidine nucleotides and three canonical nucleoside 5'-monophosphates (UMP%2C dUMP%2C and dTMP)%2C and very low activity against TDP%2C IMP%2C UDP%2C GMP%2C dGMP%2C AMP%2C dAMP%2C and 6- phosphogluconate. Appears to function as a house-cleaning nucleotidase in vivo%2C since the general nucleotidase activity of YjjG allows it to protect cells against non-canonical pyrimidine derivatives such as 5-fluoro-2'-deoxyuridine%2C 5-fluorouridine%2C 5- fluoroorotate%2C 5-fluorouracil%2C and 5-aza-2'-deoxycytidine%2C and prevents the incorporation of potentially mutagenic nucleotides into DNA. Its dUMP phosphatase activity that catalyzes the hydrolysis of dUMP to deoxyuridine is necessary for thymine utilization via the thymine salvage pathway. Is strictly specific to substrates with 5'-phosphates and shows no activity against nucleoside 2'- or 3'-monophosphates (By similarity)%3B Belongs to the HAD-like hydrolase superfamily. YjjG family gene gene3583 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03584 VSVS12_03585 VSVS12_03585 nirB nirB 601643 604216 + Nitrite reductase (NADH) Belongs to the nitrite and sulfite reductase 4Fe-4S domain family%3B KEGG: vvu:VV2_0370 nitrite reductase (NADH) large subunit gene gene3584 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03585 VSVS12_03586 VSVS12_03586 nirD nirD 604230 604553 + Nitrite reductase (NADH) Required for activity of the reductase%3B To B. subtilis NasE%3B KEGG: vpa:VPA0986 nitrite reductase (NADH) small subunit gene gene3585 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03586 VSVS12_03587 VSVS12_03587 VSVS12_03587 604664 605512 + putative transporter Belongs to the FNT transporter (TC 2. A. 44) family gene gene3586 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03587 VSVS12_03588 VSVS12_03588 VSVS12_03588 605651 606439 + Uroporphyrinogen-III C-methyltransferase Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally%2C it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme%3B In the N-terminal sectio%3B belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family%3B In the C-terminal sectio%3B belongs to the precorrin methyltransferase family%3B KEGG: vcy:IX92_08050 uroporphyrin-III C-methyltransferase gene gene3587 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03588 VSVS12_03589 VSVS12_03589 VSVS12_03589 606668 607804 + Cyclic di-GMP phosphodiesterase response regulator RpfG Member of the two-component regulatory system RpfG/RpfC%2C which is required for full virulence and for formation and dispersal of biofilms. Involved in sensing and responding to the diffusible signaling factor (DSF)%2C which is essential for cell- cell signaling. Activated RpfG degrades cyclic di-GMP%2C an unusual nucleotide second messenger%2C leading to the activation of Clp%2C a global transcriptional regulator that regulates a large set of genes in DSF pathway. May also directly control genes involved in biofilm dispersal%3B Contains 1 HD domain%3B Contains 1 response regulatory domain gene gene3588 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03589 VSVS12_03590 VSVS12_03590 VSVS12_03590 607851 608399 - hypothetical protein gene gene3589 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03590 VSVS12_03591 VSVS12_03591 VSVS12_03591 608598 609080 + hypothetical protein gene gene3590 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03591 VSVS12_03592 VSVS12_03592 VSVS12_03592 609124 609354 - hypothetical protein gene gene3591 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03592 VSVS12_03593 VSVS12_03593 VSVS12_03593 609787 610143 + hypothetical protein gene gene3592 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03593 VSVS12_03594 VSVS12_03594 VSVS12_03594 610380 611852 - Dipeptide and tripeptide permease Proton-dependent permease that transports di- and tripeptides%3B Belongs to the PTR2/POT transporter (TC 2. A. 17) family. DtpB subfamily gene gene3593 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03594 VSVS12_03595 VSVS12_03595 VSVS12_03595 612043 613434 - L-serine ammonia-lyase Deaminates also threonine%2C particularly when it is present in high concentration. Belongs to the iron-sulfur dependent L-serine dehydratase family%3B KEGG: eco:b1814 L-serine dehydratase gene gene3594 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03595 VSVS12_03596 VSVS12_03596 VSVS12_03596 613509 614465 + hypothetical protein gene gene3595 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03596 VSVS12_03597 VSVS12_03597 VSVS12_03597 614482 614760 - hypothetical protein gene gene3596 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03597 VSVS12_03598 VSVS12_03598 VSVS12_03598 614854 615813 - Diguanylate cyclase VdcA Diguanylate cyclase (DGC) that catalyzes the synthesis of cyclic diguanylate (c-di-GMP) via the condensation of 2 GTP molecules. Is involved in the modulation of intracellular c-di-GMP levels. Cyclic-di-GMP is a second messenger which positively regulates biofilm formation and negatively regulates virulence in V. cholerae%2C and is proposed to play an important role in the transition from persistence in the environment to survival in the host. Overexpression of vdcA results in increased biofilm formation%2C and reduced motility and virulence%3B Contains 1 GGDEF domain gene gene3597 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03598 VSVS12_03599 VSVS12_03599 VSVS12_03599 616100 617026 - Chemotaxis protein CheV Involved in the transmission of sensory signals from the chemoreceptors to the flagellar motors. Chemotaxis involves both a phosphorylation-dependent excitation and a methylation-dependent adaptation. CheV and CheW are involved in the coupling of the methyl-accepting chemoreceptors to the central two-component kinase Che%3B they are both necessary for efficient chemotaxis. Moreover%2C CheA-dependent phosphorylation of CheV is required for adaptation to attractants during B. subtilis chemotaxis%3B Contains 1 cheW-like domain%3B Contains 1 response regulatory domain gene gene3598 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03599 VSVS12_03600 VSVS12_03600 ppiC ppiC 617218 617496 + Peptidylprolyl isomerase PPIases accelerate the folding of proteins. It prefers amino acid residues with hydrophobic side chains like leucine and phenylalanine in the P1 position of the peptides substrates (By similarity)%3B Belongs to the PpiC/parvulin rotamase family%3B Contains 1 PpiC domain%3B KEGG: eca:ECA4216 peptidyl-prolyl cis-trans isomerase C gene gene3599 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03600 VSVS12_03601 VSVS12_03601 VSVS12_03601 617582 618514 - Kdo(2)-lipid IV(A) lauroyltransferase Catalyzes the transfer of myristate from myristoyl-acyl carrier protein (ACP) to Kdo(2)-(lauroyl)-lipid IV(A) to form Kdo(2)-lipid A. Can probably also catalyze the transfer of myristate to Kdo(2)-(palmitoleoyl)-lipid IV(A) to form the cold- adapted Kdo(2)-lipid A%3B Belongs to the LpxL/LpxM/LpxP family. LpxM subfamily%3B KEGG: smac:SMDB11_2341 KDO2-lipid IV(A) lauroyltransferase gene gene3600 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03601 VSVS12_03602 VSVS12_03602 VSVS12_03602 618630 618950 - Cytochrome c-554(548) gene gene3601 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03602 VSVS12_03603 VSVS12_03603 ltaE ltaE 619103 620107 - L-threonine aldolase Belongs to the threonine aldolase family%3B KEGG: vch:VCA0765 threonine aldolase gene gene3602 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03603 VSVS12_03604 VSVS12_03604 VSVS12_03604 620142 620672 - ADP-ribose diphosphatase Involved in the activation of the NAD-dependent methanol dehydrogenase (MDH). MDH activation by Act involves hydrolytic removal of the nicotinamide mononucleotide (NMN) moiety of the NAD cofactor%2C changing its ping-pong type of reaction mechanism into a ternary complex reaction mechanism. It requires the presence of magnesium ions and is also able to use ADP-ribose%3B Belongs to the Nudix hydrolase family%3B KEGG: vni:VIBNI_B0914 ADP-ribose pyrophosphatase gene gene3603 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03604 VSVS12_03605 VSVS12_03605 moxR moxR 620933 622597 + ATPase RavA Functions as an ATPase. May play a role in metal insertion (metal-chelatase) or as a chaperone%3B Belongs to the RavA family%3B KEGG: vcy:IX92_21485 MoxR-like ATPase%3B Acting on acid anhydrides%3B catalyzing transmembrane movement of substances gene gene3604 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03605 VSVS12_03606 VSVS12_03606 VSVS12_03606 622606 624051 + Protein ViaA Belongs to the ViaA family gene gene3605 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03606 VSVS12_03607 VSVS12_03607 VSVS12_03607 624155 625045 - hypothetical protein gene gene3606 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03607 VSVS12_03608 VSVS12_03608 VSVS12_03608 625183 625674 + HTH-type transcriptional regulator PecS Negative regulator of pectinase%2C cellulase%2C blue pigment production and virulence genes. Also binds to promoter sites in the pecS-pecM intergenic region and negatively autoregulate its expression as well as that of pecM%3B Contains 1 HTH marR-type DNA-binding domain gene gene3607 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03608 VSVS12_03609 VSVS12_03609 VSVS12_03609 625753 626109 + uncharacterized protein gene gene3608 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03609 VSVS12_03610 VSVS12_03610 VSVS12_03610 626287 626360 + tRNA-Cys tRNA gene3609 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03610 VSVS12_03611 VSVS12_03611 VSVS12_03611 626394 626469 + tRNA-Gly tRNA gene3610 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03611 VSVS12_03612 VSVS12_03612 VSVS12_03612 626554 626640 + tRNA-Leu tRNA gene3611 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03612 VSVS12_03613 VSVS12_03613 VSVS12_03613 626670 626745 + tRNA-Gly tRNA gene3612 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03613 VSVS12_03614 VSVS12_03614 VSVS12_03614 626778 626851 + tRNA-Cys tRNA gene3613 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03614 VSVS12_03615 VSVS12_03615 asnA asnA 627015 628022 - Aspartate--ammonia ligase Belongs to the class-II aminoacyl-tRNA synthetase family. AsnA subfamily%3B KEGG: ppe:PEPE_1469 aspartate--ammonia ligase gene gene3614 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03615 VSVS12_03616 VSVS12_03616 VSVS12_03616 628180 629757 - Aerotaxis receptor Signal transducer for aerotaxis. The aerotactic response is the accumulation of cells around air bubbles. The nature of the sensory stimulus detected by this protein is the proton motive force or cellular redox state. It uses a FAD prosthetic group as a redox sensor to monitor oxygen levels%3B Contains 1 methyl-accepting transducer domain%3B Contains 1 PAC (PAS-associated C-terminal) domain%3B Contains 1 PAS (PER-ARNT-SIM) domain gene gene3615 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03616 VSVS12_03617 VSVS12_03617 VSVS12_03617 630266 630352 + tRNA-Leu tRNA gene3616 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03617 VSVS12_03618 VSVS12_03618 VSVS12_03618 630379 630454 + tRNA-Gly tRNA gene3617 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03618 VSVS12_03619 VSVS12_03619 VSVS12_03619 630487 630560 + tRNA-Cys tRNA gene3618 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03619 VSVS12_03620 VSVS12_03620 VSVS12_03620 630646 631080 - hypothetical protein gene gene3619 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03620 VSVS12_03621 VSVS12_03621 VSVS12_03621 631331 631738 + uncharacterized protein gene gene3620 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03621 VSVS12_03622 VSVS12_03622 VSVS12_03622 631805 632965 - putative MFS-type transporter Belongs to the major facilitator superfamily. YcaD (TC 2. A. 1. 26) family gene gene3621 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03622 VSVS12_03623 VSVS12_03623 trxC trxC 633189 633623 - Protein-disulfide reductase Efficient electron donor for the essential enzyme ribonucleotide reductase. Is also able to reduce the interchain disulfide bridges of insulin (By similarity)%3B Belongs to the thioredoxin family%3B Contains 1 thioredoxin domain%3B KEGG: vch:VCA0752 thioredoxin 2 gene gene3622 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03623 VSVS12_03624 VSVS12_03624 VSVS12_03624 633733 634869 + Beta-ketoacyl-[acyl-carrier-protein] synthase III Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and/or straight-chain of fatty acids%3B Belongs to the FabH family%3B KEGG: gau:GAU_3169 3-oxoacyl-(acyl-carrier-protein) synthase III gene gene3623 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03624 VSVS12_03625 VSVS12_03625 VSVS12_03625 634953 636125 + Nuclease SbcCD subunit SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity (By similarity)%3B Belongs to the SbcD family gene gene3624 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03625 VSVS12_03626 VSVS12_03626 VSVS12_03626 636129 639176 + Nuclease SbcCD subunit SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity (By similarity)%3B Belongs to the SMC family. SbcC subfamily gene gene3625 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03626 VSVS12_03627 VSVS12_03627 cqsS cqsS 639328 641379 + CAI-1 autoinducer sensor kinase/phosphatase CqsS Senses the quorum-sensing autoinducer CAI-1 ((S)-3- hydroxytridecan-4-one) which probably functions as an intragenus signal. The sensory signal is then relayed to LuxU and LuxO%3B Contains 1 histidine kinase domain%3B Contains 1 response regulatory domain%3B KEGG: vpa:VPA0710 two-component system%2C CAI-1 autoinducer sensor kinase/phosphatase CqsS%3B Histidine kinase gene gene3626 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03627 VSVS12_03628 VSVS12_03628 VSVS12_03628 641411 642376 - hypothetical protein gene gene3627 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03628 VSVS12_03629 VSVS12_03629 VSVS12_03629 642504 643904 - H(+)/Cl(-) exchange transporter ClcA Proton-coupled chloride transporter. Functions as antiport system and exchanges two chloride ions for 1 proton. Probably acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation%2C as part of the extreme acid resistance (XAR) response%3B Belongs to the chloride channel (TC 2. A. 49) family. ClcA subfamily gene gene3628 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03629 VSVS12_03630 VSVS12_03630 VSVS12_03630 644479 645480 + Zinc-binding GTPase YeiR Involved in metal homeostasis. Has GTPase activity. Binds several Zn(2+) ions in vitro%3B Belongs to the SIMIBI class G3E GTPase family. CobW subfamily%3B Contains 1 cobW C-terminal domain gene gene3629 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03630 VSVS12_03631 VSVS12_03631 VSVS12_03631 645577 646521 - DAR GTPase 3%2C chloroplastic GTPase that may function in chloroplast ribosome assembly (Probable)%3B Belongs to the TRAFAC class YlqF/YawG GTPase family%3B Contains 1 CP-type G (guanine nucleotide-binding) domain gene gene3630 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03631 VSVS12_03632 VSVS12_03632 glpC glpC 647315 648598 - Glycerol-3-phosphate dehydrogenase Electron transfer protei%3B may also function as the membrane anchor for the GlpAB dimer%3B Contains 2 4Fe-4S ferredoxin-type domains%3B KEGG: vfi:VF_A0248 glycerol-3-phosphate dehydrogenase subunit C%3B overlaps another CDS with the same product name gene gene3631 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03632 VSVS12_03633 VSVS12_03633 glpB glpB 648595 649968 - Glycerol-3-phosphate dehydrogenase Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor%3B Belongs to the anaerobic G-3-P dehydrogenase subunit B family%3B KEGG: eco:b2242 glycerol-3-phosphate dehydrogenase subunit B%3B overlaps another CDS with the same product name gene gene3632 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03633 VSVS12_03634 VSVS12_03634 glpA glpA 649972 651651 - Glycerol-3-phosphate dehydrogenase Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor (By similarity)%3B Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family%3B KEGG: vfi:VF_A0250 glycerol-3-phosphate dehydrogenase gene gene3633 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03634 VSVS12_03635 VSVS12_03635 VSVS12_03635 651981 653279 - hypothetical protein gene gene3634 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03635 VSVS12_03636 VSVS12_03636 VSVS12_03636 653320 654060 - Glycerophosphodiester phosphodiesterase Glycerophosphoryl diester phosphodiesterase hydrolyzes deacylated phospholipids to G3P and the corresponding alcohols. Belongs to the glycerophosphoryl diester phosphodiesterase family%3B Contains 1 GP-PDE domain%3B KEGG: vfi:VF_A0958 glycerophosphoryl diester phosphodiesterase gene gene3635 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03636 VSVS12_03637 VSVS12_03637 VSVS12_03637 654638 655405 - L-fucose operon activator Transcriptional activator of the fuc operon. Contains 1 HTH deoR-type DNA-binding domain gene gene3636 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03637 VSVS12_03638 VSVS12_03638 glpK glpK 655587 657101 - Glycerol kinase Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate%3B Belongs to the FGGY kinase family%3B KEGG: vch:VCA0744 glycerol kinase gene gene3637 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03638 VSVS12_03639 VSVS12_03639 VSVS12_03639 657173 658027 - Glycerol uptake facilitator protein Transporter of glycerol across the cytoplasmic membrane%2C with limited permeability to water and small uncharged compounds such as polyols%3B Belongs to the MIP/aquaporin (TC 1. A. 8) family gene gene3638 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03639 VSVS12_03640 VSVS12_03640 VSVS12_03640 658492 659820 + Anaerobic C4-dicarboxylate transporter Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane%3B Belongs to the DcuA/DcuB transporter (TC 2. A. 13. 1) family gene gene3639 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03640 VSVS12_03641 VSVS12_03641 VSVS12_03641 660207 660743 - hypothetical protein gene gene3640 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03641 VSVS12_03642 VSVS12_03642 VSVS12_03642 660813 661439 - hypothetical protein gene gene3641 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03642 VSVS12_03643 VSVS12_03643 VSVS12_03643 662071 662184 + hypothetical protein gene gene3642 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03643 VSVS12_03644 VSVS12_03644 VSVS12_03644 662165 662551 - hypothetical protein gene gene3643 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03644 VSVS12_03645 VSVS12_03645 VSVS12_03645 662574 662750 - hypothetical protein gene gene3644 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03645 VSVS12_03646 VSVS12_03646 VSVS12_03646 662853 662969 - hypothetical protein gene gene3645 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03646 VSVS12_03647 VSVS12_03647 VSVS12_03647 663458 664066 - hypothetical protein gene gene3646 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03647 VSVS12_03648 VSVS12_03648 VSVS12_03648 664465 665673 - hypothetical protein gene gene3647 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03648 VSVS12_03649 VSVS12_03649 VSVS12_03649 665725 666888 + hypothetical protein gene gene3648 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03649 VSVS12_03650 VSVS12_03650 VSVS12_03650 666948 668156 + hypothetical protein gene gene3649 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03650 VSVS12_03651 VSVS12_03651 VSVS12_03651 668213 669136 - putative HTH-type transcriptional regulator LtrA Contains 1 HTH lysR-type DNA-binding domain gene gene3650 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03651 VSVS12_03652 VSVS12_03652 VSVS12_03652 669251 669364 + hypothetical protein gene gene3651 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03652 VSVS12_03653 VSVS12_03653 gcaT gcaT 669561 670754 + Glycine C-acetyltransferase Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA%3B Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family%3B KEGG: vch:VCA0886 glycine C-acetyltransferase gene gene3652 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03653 VSVS12_03654 VSVS12_03654 VSVS12_03654 670862 671902 + L-threonine 3-dehydrogenase Belongs to the zinc-containing alcohol dehydrogenase family%3B KEGG: vha:VIBHAR_05001 threonine 3-dehydrogenase gene gene3653 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03654 VSVS12_03655 VSVS12_03655 VSVS12_03655 672592 678162 + Non-specific serine/threonine protein kinase KEGG: saci:Sinac_4765 titin gene gene3654 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03655 VSVS12_03656 VSVS12_03656 VSVS12_03656 678159 681674 + hypothetical protein gene gene3655 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03656 VSVS12_03657 VSVS12_03657 VSVS12_03657 681671 682270 + Peptidylprolyl isomerase This adenylate cyclase belongs to a special class of bacterial toxin. It causes whooping cough by acting on mammalian cells by elevating cAMP-concentration and thus disrupts normal cell function. In the N-terminal sectio%3B belongs to the adenylyl cyclase class-2 family%3B In the C-terminal sectio%3B belongs to the RTX prokaryotic toxin family%3B Contains 17 hemolysin-type calcium-binding repeats%3B KEGG: arp:NIES39_L02390 peptidyl-prolyl cis-trans isomerase B (cyclophilin B) gene gene3656 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03657 VSVS12_03658 VSVS12_03658 VSVS12_03658 682487 682954 - hypothetical protein gene gene3657 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03658 VSVS12_03659 VSVS12_03659 VSVS12_03659 683548 683982 + hypothetical protein gene gene3658 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03659 VSVS12_03660 VSVS12_03660 VSVS12_03660 684051 684536 - hypothetical protein gene gene3659 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03660 VSVS12_03661 VSVS12_03661 VSVS12_03661 685125 686726 - putative acyl-activating enzyme 1%2C peroxisomal May act as an acid--thiol ligase that activates carboxylic acids by forming acyl-CoAs%3B Belongs to the ATP-dependent AMP-binding enzyme family%3B KEGG: smul:SMUL_0748 fatty-acyl-CoA synthase%3B Acid--thiol ligases gene gene3660 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03661 VSVS12_03662 VSVS12_03662 VSVS12_03662 687132 687293 - hypothetical protein gene gene3661 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03662 VSVS12_03663 VSVS12_03663 VSVS12_03663 687502 687723 - hypothetical protein gene gene3662 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03663 VSVS12_03664 VSVS12_03664 VSVS12_03664 687858 688223 - uncharacterized protein gene gene3663 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03664 VSVS12_03665 VSVS12_03665 VSVS12_03665 688426 690057 - Putative methyl-accepting chemotaxis protein YoaH Contains 1 HAMP domain%3B Contains 1 methyl-accepting transducer domain gene gene3664 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03665 VSVS12_03666 VSVS12_03666 VSVS12_03666 690648 691856 + putative transporter YutK Belongs to the concentrative nucleoside transporter (CNT) (TC 2. A. 41) family gene gene3665 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03666 VSVS12_03667 VSVS12_03667 VSVS12_03667 692217 693425 + hypothetical protein gene gene3666 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03667 VSVS12_03668 VSVS12_03668 VSVS12_03668 693422 694624 + Tripeptide aminopeptidase Cleaves the N-terminal amino acid of tripeptides%3B Belongs to the peptidase M20B family%3B KEGG: vfi:VF_A0253 tripeptide aminopeptidase gene gene3667 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03668 VSVS12_03669 VSVS12_03669 VSVS12_03669 694675 695145 + hypothetical protein gene gene3668 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03669 VSVS12_03670 VSVS12_03670 VSVS12_03670 695219 696076 + hypothetical protein gene gene3669 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03670 VSVS12_03671 VSVS12_03671 VSVS12_03671 696366 698396 + Putative permease IIC component YwbA The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS)%2C a major carbohydrate active -transport system%2C catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane%3B Contains 1 PTS EIIC type-3 domain gene gene3670 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03671 VSVS12_03672 VSVS12_03672 VSVS12_03672 698441 699526 - Arsenical-resistance protein Acr3 Catalyzes the proton motive force-dependent arsenite efflux from the cell. Probably functions as an arsenite/H(+) antiporter. Does not transport antimonite%3B Belongs to the arsenical resistance-3 (ACR3) (TC 2. A. 59) family gene gene3671 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03672 VSVS12_03673 VSVS12_03673 VSVS12_03673 699613 699963 - hypothetical protein gene gene3672 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03673 VSVS12_03674 VSVS12_03674 VSVS12_03674 700086 700703 - hypothetical protein gene gene3673 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03674 VSVS12_03675 VSVS12_03675 VSVS12_03675 701064 713309 + Poly(beta-D-mannuronate) C5 epimerase Converts beta-D-mannuronic acid (M) to alpha-L-guluronic acid (G)%2C producing a polymer with gel-forming capacity%2C required for the formation of the cyst coat. Belongs to the D-mannuronate C5-epimerase family%3B Contains 12 hemolysin-type calcium-binding repeats%3B Contains 15 PbH1 repeats gene gene3674 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03675 VSVS12_03676 VSVS12_03676 VSVS12_03676 713509 713769 + hypothetical protein gene gene3675 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03676 VSVS12_03677 VSVS12_03677 VSVS12_03677 713968 714129 - hypothetical protein gene gene3676 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03677 VSVS12_03678 VSVS12_03678 gntZ gntZ 714404 715852 - Phosphogluconate dehydrogenase (NADP(+)-dependent%2C decarboxylating) Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2)%2C with concomitant reduction of NADP to NADPH%3B Belongs to the 6-phosphogluconate dehydrogenase family%3B KEGG: hin:HI0553 6-phosphogluconate dehydrogenase gene gene3677 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03678 VSVS12_03679 VSVS12_03679 pglS pglS 715904 716620 - 6-phosphogluconolactonase Hydrolysis of 6-phosphogluconolactone to 6- phosphogluconate. Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily%3B KEGG: vvu:VV1_2683 6-phosphogluconolactonase gene gene3678 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03679 VSVS12_03680 VSVS12_03680 g6pD g6pD 716617 718200 - Glucose-6-phosphate dehydrogenase (NADP(+)) Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway%2C which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis (By similarity)%3B Belongs to the glucose-6-phosphate dehydrogenase family%3B KEGG: vvy:VV1605 glucose-6-phosphate 1-dehydrogenase gene gene3679 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03680 VSVS12_03681 VSVS12_03681 VSVS12_03681 718651 719037 + hypothetical protein gene gene3680 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03681 VSVS12_03682 VSVS12_03682 VSVS12_03682 719403 720068 + Pentapeptide repeat protein QnrB4 Probably plays a role in resistance to quinolone antibiotics (PubMed:16870791). Only inhibits ATP-dependent DNA supercoiling by E. coli gyrase at high concentration (30 uM) (PubMed:19060136). Protects E. coli gyrase supercoiling activity from inhibition by fluoroquinolones (ciprofloxacin) at 0. 1 uM%2C does not protect M. tuberculosis gyrase activity (PubMed:19060136)%3B Belongs to the pentapeptide repeat protein family%3B Contains 1 pentapeptide repeat domain gene gene3681 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03682 VSVS12_03683 VSVS12_03683 VSVS12_03683 720156 721322 - Peptide-methionine (S)-S-oxide reductase Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine%3B Belongs to the MsrA Met sulfoxide reductase family%3B KEGG: stax:MC45_08050 peptide-methionine (S)-S-oxide reductase gene gene3682 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03683 VSVS12_03684 VSVS12_03684 VSVS12_03684 721482 723248 - Formate--tetrahydrofolate ligase Belongs to the formate--tetrahydrofolate ligase family%3B KEGG: vvu:VV2_0216 formate--tetrahydrofolate ligase gene gene3683 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03684 VSVS12_03685 VSVS12_03685 VSVS12_03685 723515 724993 - Pyruvate kinase Belongs to the pyruvate kinase family%3B KEGG: pwa:Pecwa_3622 pyruvate kinase gene gene3684 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03685 VSVS12_03686 VSVS12_03686 VSVS12_03686 725146 726525 - Glycerol-3-phosphate transporter Responsible for glycerol-3-phosphate uptake%3B Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2. A. 1. 4) family gene gene3685 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03686 VSVS12_03687 VSVS12_03687 VSVS12_03687 726912 728108 + Phosphoglycerate transport regulatory protein PgtC Required for pgtP expression%2C it may act jointly with the PgtA/PgtB signaling proteins gene gene3686 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03687 VSVS12_03688 VSVS12_03688 pgtB pgtB 728108 730468 + Histidine kinase Member of the two-component regulatory system DctB/DctD involved in the transport of C4-dicarboxylates. DctB functions as a membrane-associated protein kinase that phosphorylates DctD in response to environmental signals. Contains 1 histidine kinase domain%3B KEGG: vch:VCA0705 two-component system%2C NtrC family%2C phosphoglycerate transport system sensor histidine kinase PgtB gene gene3687 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03688 VSVS12_03689 VSVS12_03689 VSVS12_03689 730455 731717 + Acid tolerance regulatory protein ActR Member of the two-component regulatory system ActS/ActR acting in acid tolerance. These data implicate that a two- component sensor may be involved in pH sensing and/or response (By similarity)%3B Contains 1 response regulatory domain gene gene3688 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03689 VSVS12_03690 VSVS12_03690 VSVS12_03690 731771 731956 - hypothetical protein gene gene3689 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03690 VSVS12_03691 VSVS12_03691 VSVS12_03691 731995 734352 - hypothetical protein gene gene3690 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03691 VSVS12_03692 VSVS12_03692 VSVS12_03692 734477 735676 - Sugar efflux transporter Involved in the efflux of sugars. The physiological role may be the reduction of the intracellular concentration of toxic sugars or sugar metabolites. Transports IPTG%2C lactose and arabinose. Belongs to the major facilitator superfamily. Set transporter family gene gene3691 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03692 VSVS12_03693 VSVS12_03693 VSVS12_03693 735669 735884 - hypothetical protein gene gene3692 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03693 VSVS12_03694 VSVS12_03694 VSVS12_03694 735890 736795 - Ferric anguibactin-binding protein Binds ferric anguibacti%3B part of the binding-protein- dependent transport system for uptake of ferric anguibactin. Belongs to the bacterial solute-binding protein 8 family%3B Contains 1 Fe/B12 periplasmic-binding domain gene gene3693 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03694 VSVS12_03695 VSVS12_03695 VSVS12_03695 736809 738725 - TonB-dependent heme receptor Heme receptor%3B Belongs to the TonB-dependent receptor family gene gene3694 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03695 VSVS12_03696 VSVS12_03696 VSVS12_03696 738964 740298 - Heme sensor protein HssS Member of the two-component regulatory system HssS/HssR involved in intracellular heme homeostasis and tempering of staphylococcal virulence. HssS functions as a heme sensor histidine kinase which is autophosphorylated at a histidine residue and transfers its phosphate group to an aspartate residue of HssR. HssR/HssS activates the expression of hrtAB%2C an efflux pump%2C in response to extracellular heme%2C hemin%2C hemoglobin or blood (By similarity)%3B Contains 1 HAMP domain%3B Contains 1 histidine kinase domain%3B KEGG: pen:PSEEN1361 null%3B Phosphotransferases with a nitrogenous group as acceptor gene gene3695 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03696 VSVS12_03697 VSVS12_03697 VSVS12_03697 740295 741056 - CAI-1 autoinducer sensor kinase/phosphatase CqsS Senses the quorum-sensing autoinducer CAI-1 ((S)-3- hydroxytridecan-4-one) which probably functions as an intragenus signal. The sensory signal is then relayed to LuxU and LuxO%3B Contains 1 histidine kinase domain%3B Contains 1 response regulatory domain gene gene3696 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03697 VSVS12_03698 VSVS12_03698 VSVS12_03698 741229 741567 - hypothetical protein To H. influenzae HI_1709 gene gene3697 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03698 VSVS12_03699 VSVS12_03699 VSVS12_03699 741628 742275 - hypothetical protein gene gene3698 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03699 VSVS12_03700 VSVS12_03700 VSVS12_03700 742498 743730 - putative MFS-type transporter Belongs to the major facilitator superfamily gene gene3699 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03700 VSVS12_03701 VSVS12_03701 VSVS12_03701 744108 744680 + hypothetical protein gene gene3700 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03701 VSVS12_03702 VSVS12_03702 VSVS12_03702 744892 746283 + Diguanylate cyclase DosC Globin-coupled heme-based oxygen sensor protein displaying diguanylate cyclase (DGC) activity in response to oxygen availability. Thus%2C catalyzes the synthesis of cyclic diguanylate (c-di-GMP) via the condensation of 2 GTP molecules. Cyclic-di-GMP is a second messenger which controls cell surface- associated traits in bacteria (By similarity)%3B Contains 1 GGDEF domain gene gene3701 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03702 VSVS12_03703 VSVS12_03703 VSVS12_03703 746426 746500 + tRNA-Gly tRNA gene3702 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03703 VSVS12_03704 VSVS12_03704 VSVS12_03704 746724 746936 - hypothetical protein gene gene3703 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03704 VSVS12_03705 VSVS12_03705 VSVS12_03705 747053 747262 + hypothetical protein gene gene3704 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03705 VSVS12_03706 VSVS12_03706 VSVS12_03706 747276 748454 + Putative lambdoid prophage Rac integrase Integrase is necessary for integration of the phage into the host genome by site-specific recombination. In conjunction with excisionase%2C integrase is also necessary for excision of the prophage from the host genome (By similarity)%3B Belongs to the 'phage' integrase family gene gene3705 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03706 VSVS12_03707 VSVS12_03707 VSVS12_03707 748451 748762 + hypothetical protein gene gene3706 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03707 VSVS12_03708 VSVS12_03708 VSVS12_03708 749673 751385 + hypothetical protein gene gene3707 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03708 VSVS12_03709 VSVS12_03709 VSVS12_03709 751985 752128 + hypothetical protein gene gene3708 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03709 VSVS12_03710 VSVS12_03710 VSVS12_03710 752125 753429 + DNA-damage-inducible protein Belongs to the multi antimicrobial extrusion (MATE) (TC 2. A. 66. 1) family gene gene3709 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03710 VSVS12_03711 VSVS12_03711 VSVS12_03711 753708 754469 + Fe(3+) ions import ATP-binding protein FbpC Part of the ABC transporter complex FbpABC involved in Fe(3+) ions import. Responsible for energy coupling to the transport system%3B Belongs to the ABC transporter superfamily. Fe(3+) ion importer (TC 3. A. 1. 10) family%3B Contains 1 ABC transporter domain gene gene3710 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03711 VSVS12_03712 VSVS12_03712 VSVS12_03712 754490 755338 + Phosphonates import ATP-binding protein PhnC Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system%3B Belongs to the ABC transporter superfamily. Phosphonates importer (TC 3. A. 1. 9. 1) family%3B Contains 1 ABC transporter domain gene gene3711 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03712 VSVS12_03713 VSVS12_03713 VSVS12_03713 755328 756842 + Periplasmic dipeptide transport protein Dipeptide-binding protein of a transport system that can be subject to osmotic shock. DppA is also required for peptide chemotaxis. Belongs to the bacterial solute-binding protein 5 family gene gene3712 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03713 VSVS12_03714 VSVS12_03714 VSVS12_03714 756889 758610 + Dipeptide transport system permease protein DppB Part of the binding-protein-dependent transport system for dipeptide%3B probably responsible for the translocation of the substrate across the membrane. Is expressed to facilitate adaptation to nutrient deficiency conditions. Belongs to the binding-protein-dependent transport system permease family. OppBC subfamily%3B Contains 1 ABC transmembrane type-1 domain gene gene3713 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03714 VSVS12_03715 VSVS12_03715 VSVS12_03715 758748 759026 + hypothetical protein gene gene3714 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03715 VSVS12_03716 VSVS12_03716 VSVS12_03716 759210 759791 - hypothetical protein gene gene3715 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03716 VSVS12_03717 VSVS12_03717 VSVS12_03717 760077 760322 + hypothetical protein gene gene3716 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03717 VSVS12_03718 VSVS12_03718 VSVS12_03718 760449 761291 - Maltose operon periplasmic protein Not yet known. Might function in the uptake of a still unidentified substrate. To S. typhimurium MalM gene gene3717 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03718 VSVS12_03719 VSVS12_03719 VSVS12_03719 761377 762714 - Maltoporin Involved in the transport of maltose and maltodextrins%3B Belongs to the porin LamB (TC 1. B. 3) family gene gene3718 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03719 VSVS12_03720 VSVS12_03720 VSVS12_03720 763486 764376 - Maltose transport system permease protein Part of the binding-protein-dependent transport system for maltos%3B probably responsible for the translocation of the substrate across the membrane. Belongs to the binding-protein-dependent transport system permease family. MalFG subfamily%3B Contains 1 ABC transmembrane type-1 domain gene gene3719 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03720 VSVS12_03721 VSVS12_03721 VSVS12_03721 764389 765963 - Maltose transport system permease protein MalF Part of a binding-protein-dependent transport system. Probably responsible for the translocation of the substrate across the membrane (By similarity)%3B Belongs to the binding-protein-dependent transport system permease family. MalFG subfamily%3B Contains 1 ABC transmembrane type-1 domain gene gene3720 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03721 VSVS12_03722 VSVS12_03722 VSVS12_03722 766044 767222 - Maltose-binding periplasmic protein Involved in the high-affinity maltose membrane transport system MalEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides (By similarity)%3B Belongs to the bacterial solute-binding protein 1 family gene gene3721 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03722 VSVS12_03723 VSVS12_03723 VSVS12_03723 767838 768950 + Lipopolysaccharide export system ATP-binding protein LptB Part of the ABC transporter complex LptBFG involved in the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane. Probably responsible for energy coupling to the transport system (By similarity)%3B Belongs to the ABC transporter superfamily. Outer membrane lipopolysaccharide export (TC 1. B. 42) family%3B Contains 1 ABC transporter domain%3B KEGG: eco:b3201 lipopolysaccharide export system ATP-binding protein%3B Acting on acid anhydrides%3B catalyzing transmembrane movement of substances gene gene3722 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03723 VSVS12_03724 VSVS12_03724 VSVS12_03724 768973 772014 + HTH-type transcriptional regulator MalR Transcriptional repressor of the maltosaccharide utilization operon malEFG. Contains 1 HTH lacI-type DNA-binding domain gene gene3723 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03724 VSVS12_03725 VSVS12_03725 VSVS12_03725 772375 774366 - Methyl-accepting chemotaxis protein NahY Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment%2C transduce a signal from the outside to the inside of the cell%2C and facilitate sensory adaptation through the variation of the level of methylation. Chemoreceptor for naphthalene or a related compound. May facilitate biodegradation%3B Contains 1 HAMP domain%3B Contains 1 methyl-accepting transducer domain gene gene3724 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03725 VSVS12_03726 VSVS12_03726 VSVS12_03726 774418 776478 - Alpha-amylase Since only maltooligosaccharides up to a chain length of 6 glucose units are actively transported through the cytoplasmic membrane via the membrane-bound complex of three proteins%2C MalF%2C MalG%2C and MalK%2C longer maltooligosaccharides must first be degraded by the periplasmic alpha-amylase%2C the MalS protein. Belongs to the glycosyl hydrolase 13 family%3B KEGG: vcy:IX92_23125 alpha-amylase gene gene3725 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03726 VSVS12_03727 VSVS12_03727 VSVS12_03727 776539 778719 - 4-alpha-glucanotransferase Belongs to the disproportionating enzyme family%3B KEGG: vvu:VV2_1251 4-alpha-glucanotransferase gene gene3726 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03727 VSVS12_03728 VSVS12_03728 VSVS12_03728 778801 781254 - Glycogen phosphorylase Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However%2C all known phosphorylases share catalytic and structural properties (By similarity)%3B Belongs to the glycogen phosphorylase family%3B KEGG: puv:PUV_22600 starch phosphorylase gene gene3727 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03728 VSVS12_03729 VSVS12_03729 VSVS12_03729 781861 784569 + HTH-type transcriptional regulator MalT Positively regulates the transcription of the maltose regulon whose gene products are responsible for uptake and catabolism of malto-oligosaccharides. Binds and recognizes a DNA motif (called the malT box): 5'-GGA[TG]GA-3'%3B Contains 1 HTH luxR-type DNA-binding domain gene gene3728 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03729 VSVS12_03730 VSVS12_03730 VSVS12_03730 784797 787790 - hypothetical protein gene gene3729 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03730 VSVS12_03731 VSVS12_03731 VSVS12_03731 787784 790003 - hypothetical protein gene gene3730 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03731 VSVS12_03732 VSVS12_03732 VSVS12_03732 790981 791997 + hypothetical protein gene gene3731 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03732 VSVS12_03733 VSVS12_03733 VSVS12_03733 791994 792674 + hypothetical protein gene gene3732 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03733 VSVS12_03734 VSVS12_03734 VSVS12_03734 792744 793865 + Putative transposase YncI Belongs to the transposase 11 family gene gene3733 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03734 VSVS12_03735 VSVS12_03735 VSVS12_03735 793872 794855 + hypothetical protein gene gene3734 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03735 VSVS12_03736 VSVS12_03736 VSVS12_03736 794953 796107 - hypothetical protein gene gene3735 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03736 VSVS12_03737 VSVS12_03737 VSVS12_03737 796229 797473 + hypothetical protein gene gene3736 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03737 VSVS12_03738 VSVS12_03738 VSVS12_03738 797628 799007 - hypothetical protein gene gene3737 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03738 VSVS12_03739 VSVS12_03739 VSVS12_03739 798997 799674 - hypothetical protein gene gene3738 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03739 VSVS12_03740 VSVS12_03740 VSVS12_03740 799617 800213 - hypothetical protein gene gene3739 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03740 VSVS12_03741 VSVS12_03741 VSVS12_03741 800700 801908 - hypothetical protein gene gene3740 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03741 VSVS12_03742 VSVS12_03742 VSVS12_03742 801968 802624 - hypothetical protein gene gene3741 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03742 VSVS12_03743 VSVS12_03743 VSVS12_03743 802676 803884 + hypothetical protein gene gene3742 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03743 VSVS12_03744 VSVS12_03744 VSVS12_03744 803894 804400 - hypothetical protein gene gene3743 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03744 VSVS12_03745 VSVS12_03745 VSVS12_03745 805000 805323 + hypothetical protein gene gene3744 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03745 VSVS12_03746 VSVS12_03746 VSVS12_03746 806227 807735 - Putative transposase Contains 1 integrase catalytic domain gene gene3745 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03746 VSVS12_03747 VSVS12_03747 VSVS12_03747 808272 808508 + hypothetical protein gene gene3746 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03747 VSVS12_03748 VSVS12_03748 VSVS12_03748 808884 810203 - Protein ABC1 like protein%2C mitochondrial Belongs to the protein kinase superfamily. ADCK protein kinase family gene gene3747 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03748 VSVS12_03749 VSVS12_03749 VSVS12_03749 810632 810985 - uncharacterized protein gene gene3748 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03749 VSVS12_03750 VSVS12_03750 VSVS12_03750 811179 811667 - hypothetical protein gene gene3749 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03750 VSVS12_03751 VSVS12_03751 VSVS12_03751 812024 812377 + Spermidine export protein MdtJ Catalyzes the excretion of spermidine%3B Belongs to the small multidrug resistance (SMR) protein family. MdtJ subfamily gene gene3750 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03751 VSVS12_03752 VSVS12_03752 VSVS12_03752 812563 814188 - Protein BcsG like protein gene gene3751 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03752 VSVS12_03753 VSVS12_03753 VSVS12_03753 814192 814353 - hypothetical protein gene gene3752 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03753 VSVS12_03754 VSVS12_03754 VSVS12_03754 814356 815933 - Protein BcsE like protein gene gene3753 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03754 VSVS12_03755 VSVS12_03755 VSVS12_03755 816605 817381 + Putative cellulose biosynthesis protein BcsQ Essential for cellulose biosynthesis. May play a role in subcellular localization of an active cellulose biosynthesis apparatus at the bacterial cell pole%3B Belongs to the BcsQ family gene gene3754 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03755 VSVS12_03756 VSVS12_03756 VSVS12_03756 817384 820020 + Cellulose synthase (UDP-forming) Catalytic subunit of cellulose synthase. It polymerizes uridine 5'-diphosphate glucose to cellulose%2C which is produced as an extracellular component for mechanical and chemical protection at the onset of the stationary phase%2C when the cells exhibit multicellular behavior (rdar morphotype). Coexpression of cellulose and thin aggregative fimbriae leads to a hydrophobic network with tightly packed cells embedded in a highly inert matrix (By similarity)%3B Belongs to the glycosyltransferase 2 family%3B Contains 1 PilZ domain%3B KEGG: vpf:M634_06040 cellulose synthase (UDP-forming)%3B overlaps another CDS with the same product name gene gene3755 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03756 VSVS12_03757 VSVS12_03757 VSVS12_03757 820007 822295 + Cellulose synthase (UDP-forming) Binds the cellulose synthase activator%2C bis-(3'-5') cyclic diguanylic acid (c-di-GMP)%3B Belongs to the AcsB/BcsB family%3B KEGG: sphi:TS85_08140 cellulose synthase (UDP-forming)%3B overlaps another CDS with the same product name gene gene3756 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03757 VSVS12_03758 VSVS12_03758 VSVS12_03758 822292 822549 + Cellulase Hydrolyzes carboxymethylcellulose%3B Belongs to the glycosyl hydrolase 8 (cellulase D) family%3B KEGG: svo:SVI_0127 endoglucanase gene gene3757 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03758 VSVS12_03759 VSVS12_03759 VSVS12_03759 822603 823397 + Cellulase Hydrolyzes carboxymethylcellulose%3B Belongs to the glycosyl hydrolase 8 (cellulase D) family%3B KEGG: kox:KOX_05385 endoglucanase gene gene3758 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03759 VSVS12_03760 VSVS12_03760 VSVS12_03760 823445 827161 + Cellulase Required for maximal bacterial cellulose synthesis%3B Belongs to the AcsC/BcsC family%3B Contains 8 TPR repeats%3B KEGG: zmn:Za10_0232 endoglucanase gene gene3759 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03760 VSVS12_03761 VSVS12_03761 VSVS12_03761 827323 827685 + hypothetical protein gene gene3760 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03761 VSVS12_03762 VSVS12_03762 VSVS12_03762 827773 829542 - Methyl-accepting chemotaxis protein Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment%2C transduce a signal from the outside to the inside of the cell%2C and facilitate sensory adaptation through the variation of the level of methylation%3B Contains 1 HAMP domain%3B Contains 1 methyl-accepting transducer domain gene gene3761 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03762 VSVS12_03763 VSVS12_03763 pgmB pgmB 829671 830279 + Beta-phosphoglucomutase Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family%3B KEGG: cau:Caur_2018 beta-phosphoglucomutase gene gene3762 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03763 VSVS12_03764 VSVS12_03764 VSVS12_03764 830376 831683 - Inosine kinase Belongs to the carbohydrate kinase PfkB family%3B KEGG: epr:EPYR_02793 inosine kinase gene gene3763 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03764 VSVS12_03765 VSVS12_03765 VSVS12_03765 831789 832259 - hypothetical protein gene gene3764 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03765 VSVS12_03766 VSVS12_03766 VSVS12_03766 832422 832934 + hypothetical protein gene gene3765 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03766 VSVS12_03767 VSVS12_03767 VSVS12_03767 833004 834752 + Cyclic di-GMP phosphodiesterase response regulator RpfG Member of the two-component regulatory system RpfG/RpfC%2C which is required for full virulence and for formation and dispersal of biofilms. Involved in sensing and responding to the diffusible signaling factor (DSF)%2C which is essential for cell- cell signaling. Activated RpfG degrades cyclic di-GMP%2C an unusual nucleotide second messenger%2C leading to the activation of Clp%2C a global transcriptional regulator that regulates a large set of genes in DSF pathway. May also directly control genes involved in biofilm dispersal%3B Contains 1 HD domain%3B Contains 1 response regulatory domain gene gene3766 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03767 VSVS12_03768 VSVS12_03768 VSVS12_03768 834909 835550 + Phosphoglycolate phosphatase Catalyzes strongly the dephosphorylation of 6- phosphogluconate (6P-Glu) and slightly the dephosphorylation of dihydroxyacetone phosphate (DHAP) and phosphoenolpyruvate (PEP). Also hydrolyzes both purines (GMP and IMP) and pyrimidines as secondary substrates%3B Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family%3B KEGG: ava:Ava_0109 phosphoglycolate phosphatase gene gene3767 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03768 VSVS12_03769 VSVS12_03769 VSVS12_03769 835604 835810 - hypothetical protein gene gene3768 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03769 VSVS12_03770 VSVS12_03770 VSVS12_03770 836125 836445 + Protein CutA 1%2C chloroplastic Belongs to the CutA family gene gene3769 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03770 VSVS12_03771 VSVS12_03771 VSVS12_03771 836409 837026 - Inner membrane protein YjdF gene gene3770 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03771 VSVS12_03772 VSVS12_03772 VSVS12_03772 837314 837934 + hypothetical protein gene gene3771 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03772 VSVS12_03773 VSVS12_03773 VSVS12_03773 838034 839689 - hypothetical protein gene gene3772 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03773 VSVS12_03774 VSVS12_03774 VSVS12_03774 839829 841727 - putative signaling protein Contains 1 EAL domain%3B Contains 1 GGDEF domain%3B Contains 1 MHYT domain%3B Contains 1 PAS (PER-ARNT-SIM) domain%3B KEGG: mbu:Mbur_0768 null%3B Phosphotransferases with a nitrogenous group as acceptor gene gene3773 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03774 VSVS12_03775 VSVS12_03775 VSVS12_03775 841923 843143 - Enoyl-[acyl-carrier-protein] reductase (NADH) Involved in the final reduction of the elongation cycle of fatty acid synthesis (FAS II). Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP)%3B Belongs to the TER reductase family%3B KEGG: vch:VCA0784 enoyl-(acyl-carrier protein) reductase / trans-2-enoyl-CoA reductase (NAD+) gene gene3774 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03775 VSVS12_03776 VSVS12_03776 tesA tesA 843218 843820 - Esterase TesA Esterase that exhibits the highest activity towards Tween detergents and p-nitrophenyl esters of short acyl chain length. Also displays a low thioesterase activity towards palmitoyl-coenzyme A%2C but is not active towards acetyl-coenzyme A%3B Belongs to the 'GDSL' lipolytic enzyme family%3B KEGG: lag:N175_15565 acyl-CoA thioesterase I%3B Thiolester hydrolases gene gene3775 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03776 VSVS12_03777 VSVS12_03777 VSVS12_03777 843831 844493 + Spermidine/putrescine import ATP-binding protein PotA Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system%3B Belongs to the ABC transporter superfamily. Spermidine/putrescine importer (TC 3. A. 1. 11. 1) family%3B Contains 1 ABC transporter domain gene gene3776 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03777 VSVS12_03778 VSVS12_03778 VSVS12_03778 844493 846931 + putative ABC transporter permease Belongs to the ABC-4 integral membrane protein family gene gene3777 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03778 VSVS12_03779 VSVS12_03779 VSVS12_03779 847219 848682 + hypothetical protein gene gene3778 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03779 VSVS12_03780 VSVS12_03780 VSVS12_03780 848790 849725 - KipI antagonist Counteracts the inhibitory action of KipI on sporulation. May bind to KipI%2C preventing its function as an inhibitor of kinase A gene gene3779 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03780 VSVS12_03781 VSVS12_03781 VSVS12_03781 849718 850428 - Kinase A inhibitor Is a potent inhibitor of the autophosphorylation reaction of kinase A and its reverse reaction%2C but does not inhibit phosphate transfer to the Spo0F response regulator once kinase A is phosphorylated. KipI is an inhibitor of the catalytic domain of kinase A affecting the ATP/ADP reactions and not the phosphotransferase functions of this domain. The inhibition is noncompetitive with respect to ATP gene gene3780 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03781 VSVS12_03782 VSVS12_03782 VSVS12_03782 850418 851170 - UPF0271 protein Belongs to the UPF0271 (lamB) family gene gene3781 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03782 VSVS12_03783 VSVS12_03783 VSVS12_03783 851430 852257 + UDP-glucose 4-epimerase Involved in the metabolism of galactose. Catalyzes the conversion of UDP-galactose (UDP-Gal) to UDP-glucose (UDP-Glc) through a mechanism involving the transient reduction of NAD (By similarity)%3B Belongs to the NAD(P)-dependent epimerase/dehydratase family%3B KEGG: eco:b0759 UDP-glucose 4-epimerase gene gene3782 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03783 VSVS12_03784 VSVS12_03784 VSVS12_03784 852458 852709 + hypothetical protein gene gene3783 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03784 VSVS12_03785 VSVS12_03785 VSVS12_03785 852699 852986 + mRNA interferase RelE Toxic component of a type II toxin-antitoxin (TA) module (PubMed:9767574). A sequence-specific%2C ribosome-dependent mRNA endoribonuclease that inhibits translation during amino acid starvation (the stringent response). In vitro acts by cleaving mRNA with high codon specificity in the ribosomal A site between positions 2 and 3. The stop codon UAG is cleaved at a fast rate while UAA and UGA are cleaved with intermediate and slow rates. In vitro mRNA cleavage can also occur in the ribosomal E site after peptide release from peptidyl-tRNA in the P site as well as on free 30S subunits (PubMed:12526800). In vivo cuts frequently in the first 100 codons%2C most frequently after the second and third base and rarely near the stop codon (PubMed:21324908). Overexpression of RelE results in the inhibition of bacterial growth and a sharp decrease in colony-forming ability which is neutralized by the labile cognate antitoxin RelB. Overexpression also sharply increases persisters (cells that neither grow nor die in the presence of bactericidal agents and are largely responsible for high levels of biofilm tolerance to antimicrobials) (PubMed:15576765). Plays a role in dormancy when expressed in high-density cells in the absence of antitoxin Rel%3B amino acid starvation and an unidentified extracellular factor promote dormancy%2C while expression of antitoxin RelB restores cell culturability (PubMed:22210768). Acts with RelB as a corepressor of relBE transcription%2C considerably increasing the repression of RelB alone. 2 RelB dimers bind to 2 operator sequence%3B DNA- binding and repression is stronger when complexed with toxin/corepressor RelE by conditional cooperativity (PubMed:9767574%2C PubMed:19747491%2C PubMed:18501926%2C PubMed:22981948)%3B Seems to be a principal mediator of cell death in liquid media (PubMed:19707553). Implicated in hydroxy radical-mediated cell death induced by hydroxyurea treatment (PubMed:20005847)%3B Cross-talk can occur between different TA modules. Ectopic expression of this toxin induces transcription of 7 tested TA modules (dinJ/yafQ%2C hicAB%2C mazEF%2C mqsRA%2C prlF(sohA)/yhaV%2C relBEF and yefM/yoeB) with specific cleavage of the relBEF mRNA produced immediately upstream and within the relB coding sequence. The cleaved mRNA can be translated into RelE%2C leading to a positive feedback cycle of RelE expression. The relBEF operon is required for transcription of the mazEF TA module operon during amino acid starvation%3B Belongs to the RelE toxin family gene gene3784 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03785 VSVS12_03786 VSVS12_03786 VSVS12_03786 853025 853993 - Transposase for insertion sequence element IS4351 Required for the transposition of the insertion element%3B Belongs to the transposase IS30 family%3B Contains 1 integrase catalytic domain gene gene3785 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03786 VSVS12_03787 VSVS12_03787 VSVS12_03787 854024 854281 + UDP-glucose 4-epimerase Involved in the metabolism of galactose. Catalyzes the conversion of UDP-galactose (UDP-Gal) to UDP-glucose (UDP-Glc) through a mechanism involving the transient reduction of NAD. It is only active on UDP-galactose and UDP-glucose%3B Belongs to the NAD(P)-dependent epimerase/dehydratase family%3B KEGG: sbm:Shew185_1477 UDP-glucose 4-epimerase gene gene3786 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03787 VSVS12_03788 VSVS12_03788 VSVS12_03788 854433 856424 - Transketolase Catalyzes the reversible transfer of a two-carbon ketol group from sedoheptulose-7-phosphate to glyceraldehyde-3- phosphate%2C producing xylulose-5-phosphate and ribose-5-phosphate. Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor%2C via a covalent intermediate with the cofactor thiamine pyrophosphate%3B Belongs to the transketolase family%3B KEGG: wbr:WGLp582 transketolase gene gene3787 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03788 VSVS12_03789 VSVS12_03789 VSVS12_03789 856519 857469 - Transaldolase Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway%3B Belongs to the transaldolase family. Type 1 subfamily%3B KEGG: vch:VCA0623 transaldolase gene gene3788 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03789 VSVS12_03790 VSVS12_03790 dhaK dhaK 857936 858937 + Transcriptional regulator LsrR Regulates transcription of many different genes. In the absence of autoinducer 2 (AI-2)%2C represses transcription of the lsrACDBFG operon and its own transcription. In the presence of AI- 2%2C LsrR is inactivated by binding phospho-AI-2%2C leading to the transcription of the lsr genes (By similarity)%3B Belongs to the SorC transcriptional regulatory family%3B KEGG: sme:SM_b20312 dihydroxyacetone kinase%2C N-terminal domain%3B Phosphotransferases with an alcohol group as acceptor gene gene3789 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03790 VSVS12_03791 VSVS12_03791 VSVS12_03791 859083 860375 + Chitinase Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily%3B KEGG: vha:VIBHAR_06254 chitinase gene gene3790 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03791 VSVS12_03792 VSVS12_03792 mpsT mpsT 860435 861211 - Thiosulfate sulfurtransferase Catalyzes the transfer of a sulfur ion from a donor to cyanide or to other thiol compounds. Substrate preference is 3- mercaptopyruvate > thiosulfate. Involved in embryo and seed development%3B Contains 2 rhodanese domains%3B KEGG: vch:VCA0620 thiosulfate/3-mercaptopyruvate sulfurtransferase gene gene3791 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03792 VSVS12_03793 VSVS12_03793 VSVS12_03793 861288 861587 - hypothetical protein gene gene3792 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03793 VSVS12_03794 VSVS12_03794 VSVS12_03794 861622 862377 - Adenylyltransferase and sulfurtransferase MOCS3 Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys)%2C tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers URM1 and MOCS2A. Its N-terminus first activates URM1 and MOCS2A as acyl-adenylates (-COAMP)%2C then the persulfide sulfur on the catalytic cysteine is transferred to URM1 and MOCS2A to form thiocarboxylation (-COSH) of their C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards URM1 and MOCS2A. Subsequently%2C a transient disulfide bond is formed. Does not use thiosulfate as sulfur dono%3B NFS1 probably acting as a sulfur donor for thiocarboxylation reactions%3B In the N-terminal sectio%3B belongs to the HesA/MoeB/ThiF family. UBA4 subfamily%3B Contains 1 rhodanese domain gene gene3793 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03794 VSVS12_03795 VSVS12_03795 moeA moeA 862386 863621 - Molybdopterin molybdotransferase Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP%3B Belongs to the MoeA family%3B KEGG: vch:VCA0617 molybdopterin molybdotransferase gene gene3794 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03795 VSVS12_03796 VSVS12_03796 gch1 gch1 863804 864457 + GTP cyclohydrolase I Belongs to the GTP cyclohydrolase I family%3B KEGG: vch:VCA0616 GTP cyclohydrolase I gene gene3795 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03796 VSVS12_03797 VSVS12_03797 VSVS12_03797 864570 865946 + RNA helicase ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation%2C eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit%2C and subsequent scanning for the initiator codon (By similarity)%3B Belongs to the DEAD box helicase family. eIF4A subfamily%3B Contains 1 helicase ATP-binding domain%3B Contains 1 helicase C-terminal domain%3B KEGG: hav:AT03_19130 ATP-independent RNA helicase DbpA gene gene3796 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03797 VSVS12_03798 VSVS12_03798 VSVS12_03798 866051 867754 - D-lactate dehydrogenase First component of the membrane-bound D-lactate oxidase%2C which is believed to play an important role in the energization of the active transport of a variety of sugars and amino acids%3B Contains 1 FAD-binding PCMH-type domain%3B KEGG: vha:VIBHAR_05675 D-lactate dehydrogenase gene gene3797 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03798 VSVS12_03799 VSVS12_03799 desC desC 868087 869214 - Stearoyl-CoA 9-desaturase Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates. Has high specificity and catalyzes the insertion of a cis double bond at the delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA. Contributes to the biosynthesis of membrane phospholipids%2C cholesterol esters and triglycerides%3B Belongs to the fatty acid desaturase family%3B Contains 1 cytochrome b5 heme-binding domain%3B KEGG: vsp:VS_II0610 stearoyl-CoA desaturase (delta-9 desaturase) gene gene3798 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03799 VSVS12_03800 VSVS12_03800 VSVS12_03800 869392 869952 + hypothetical protein gene gene3799 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03800 VSVS12_03801 VSVS12_03801 VSVS12_03801 869997 870113 + hypothetical protein gene gene3800 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03801 VSVS12_03802 VSVS12_03802 VSVS12_03802 870052 871173 + Efflux pump periplasmic linker BepF May contribute to resistance to some drugs%2C such as deoxycholate%2C sodium dodecyl sulfate and nalidixic acid%2C in the absence of BepD and BepE%3B Belongs to the membrane fusion protein (MFP) (TC 8. A. 1) family gene gene3801 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03802 VSVS12_03803 VSVS12_03803 VSVS12_03803 871185 874337 + Antibiotic efflux pump membrane transporter ArpB The inner membrane transporter component of an antibiotic efflux pump. Confers resistance to numerous structurally unrelated antibiotics such as carbenicillin%2C chloramphenicol%2C erythromycin%2C novobiocin%2C streptomycin and tetracycline. Is not involved in organic solvent efflux. Belongs to the resistance-nodulation-cell division (RND) (TC 2. A. 6) family gene gene3802 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03803 VSVS12_03804 VSVS12_03804 VSVS12_03804 874390 875781 - putative multidrug resistance protein NorM Multidrug efflux pump%3B Belongs to the multi antimicrobial extrusion (MATE) (TC 2. A. 66. 1) family gene gene3803 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03804 VSVS12_03805 VSVS12_03805 VSVS12_03805 875877 876728 + hypothetical protein gene gene3804 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03805 VSVS12_03806 VSVS12_03806 VSVS12_03806 876807 877145 + hypothetical protein gene gene3805 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03806 VSVS12_03807 VSVS12_03807 VSVS12_03807 877252 878457 - Multidrug resistance protein Multidrug resistance pump that participates in a low energy shock adaptive response. Belongs to the major facilitator superfamily gene gene3806 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03807 VSVS12_03808 VSVS12_03808 VSVS12_03808 879059 879535 - putative HTH-type transcriptional regulator YsmB Contains 1 HTH marR-type DNA-binding domain gene gene3807 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03808 VSVS12_03809 VSVS12_03809 VSVS12_03809 879874 881445 + Glycine betaine transporter BetL High-affinity uptake of glycine betaine%2C driven by a sodium-motive force. Involved%2C with GbuABC and OpuC%2C in osmoprotection and cryoprotection of Listeria. Does not mediate either carnitine or choline uptake%3B Belongs to the BCCT transporter (TC 2. A. 15) family gene gene3808 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03809 VSVS12_03810 VSVS12_03810 VSVS12_03810 881584 882303 - DNA-directed DNA polymerase KEGG: vfu:vfu_A01763 DNA polymerase III subunit epsilon gene gene3809 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03810 VSVS12_03811 VSVS12_03811 VSVS12_03811 882311 884200 - CBS domain-containing protein YhcV Contains 2 CBS domains gene gene3810 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03811 VSVS12_03812 VSVS12_03812 VSVS12_03812 884504 885700 - Tyrosine-specific transport protein Involved in transporting tyrosine across the cytoplasmic membrane%3B Belongs to the amino acid/polyamine transporter 2 family. Mtr/TnaB/TyrP permease subfamily gene gene3811 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03812 VSVS12_03813 VSVS12_03813 VSVS12_03813 886026 886145 + hypothetical protein gene gene3812 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03813 VSVS12_03814 VSVS12_03814 acpH acpH 886258 886845 + [Acyl-carrier-protein] phosphodiesterase Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP%3B Belongs to the AcpH family%3B KEGG: eco:b0404 acyl carrier protein phosphodiesterase gene gene3813 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03814 VSVS12_03815 VSVS12_03815 rhlE rhlE 886904 888163 + RNA helicase ATP-dependent RNA helicase involved spliceosome assembly and in nuclear splicing. Catalyzes an ATP-dependent conformational change of U2 snRNP. Bridges U1 and U2 snRNPs and enables stable U2 snRNP association with intron RNA (By similarity)%3B Belongs to the DEAD box helicase family. DDX46/PRP5 subfamily%3B Contains 1 helicase ATP-binding domain%3B Contains 1 helicase C-terminal domain%3B KEGG: sur:STAUR_8180 ATP-dependent RNA helicase RhlE gene gene3814 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03815 VSVS12_03816 VSVS12_03816 VSVS12_03816 888279 888746 - hypothetical protein gene gene3815 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03816 VSVS12_03817 VSVS12_03817 VSVS12_03817 888798 890006 + hypothetical protein gene gene3816 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03817 VSVS12_03818 VSVS12_03818 VSVS12_03818 890016 890384 - hypothetical protein gene gene3817 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03818 VSVS12_03819 VSVS12_03819 phbB phbB 891371 892111 + Acetoacetyl-CoA reductase Belongs to the short-chain dehydrogenases/reductases (SDR) family%3B KEGG: vch:VCA0691 acetoacetyl-CoA reductase gene gene3818 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03819 VSVS12_03820 VSVS12_03820 VSVS12_03820 892127 893341 + Acetyl-CoA C-acetyltransferase Abolishes BNIP3-mediated apoptosis and mitochondrial damage%3B Belongs to the thiolase family%3B KEGG: kpk:A593_21990 acetyl-CoA C-acetyltransferase gene gene3819 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03820 VSVS12_03821 VSVS12_03821 VSVS12_03821 893367 893714 + hypothetical protein gene gene3820 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03821 VSVS12_03822 VSVS12_03822 phbC phbC 893774 895558 + Poly(3-hydroxyalkanoate) polymerase Belongs to the PHA/PHB synthase family%3B KEGG: vvu:VV2_0739 polyhydroxyalkanoate synthase%3B Transferring groups other than amino-acyl groups gene gene3821 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03822 VSVS12_03823 VSVS12_03823 VSVS12_03823 895867 896523 + Outer membrane lipoprotein Blc Involved in the storage or transport of lipids necessary for membrane maintenance under stressful conditions. Displays a binding preference for lysophospholipids (By similarity)%3B Belongs to the calycin superfamily. Lipocalin family gene gene3822 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03823 VSVS12_03824 VSVS12_03824 VSVS12_03824 896697 897758 + hypothetical protein gene gene3823 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03824 VSVS12_03825 VSVS12_03825 VSVS12_03825 898094 898513 + UPF0394 membrane protein Belongs to the UPF0394 family gene gene3824 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03825 VSVS12_03826 VSVS12_03826 VSVS12_03826 898521 898955 + UPF0394 membrane protein Belongs to the UPF0394 family gene gene3825 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03826 VSVS12_03827 VSVS12_03827 VSVS12_03827 899065 900273 + hypothetical protein gene gene3826 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03827 VSVS12_03828 VSVS12_03828 VSVS12_03828 900329 901270 - hypothetical protein gene gene3827 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03828 VSVS12_03829 VSVS12_03829 nrdD nrdD 901529 903649 + Ribonucleoside-triphosphate reductase Belongs to the anaerobic ribonucleoside-triphosphate reductase family%3B Contains 1 ATP-cone domain%3B Contains 1 glycine radical domain%3B KEGG: yru:BD65_2386 ribonucleoside-triphosphate reductase gene gene3828 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03829 VSVS12_03830 VSVS12_03830 nrdG nrdG 903715 904182 + [Formate-C-acetyltransferase]-activating enzyme Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical%2C using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine%3B Belongs to the organic radical-activating enzymes family%3B KEGG: eco:b4237 anaerobic ribonucleoside-triphosphate reductase activating protein gene gene3829 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03830 VSVS12_03831 VSVS12_03831 VSVS12_03831 904356 905102 + hypothetical protein gene gene3830 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03831 VSVS12_03832 VSVS12_03832 VSVS12_03832 905302 906483 + Aspartate transaminase Catalyzes the irreversible transamination of the L- tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids (By similarity)%3B Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family%3B KEGG: vfu:vfu_B00279 aspartate aminotransferase gene gene3831 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03832 VSVS12_03833 VSVS12_03833 VSVS12_03833 906543 907223 + putative alpha-L-glutamate ligase In the C-terminal sectio%3B belongs to the RimK family%3B Contains 1 ATP-grasp domain%3B KEGG: dps:DP2392 ribosomal protein S6--L-glutamate ligase%3B Acid--amino-acid ligases (peptide synthases) gene gene3832 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03833 VSVS12_03834 VSVS12_03834 VSVS12_03834 907304 907777 - Peptidylprolyl isomerase Essential virulence factor associated with macrophage infectivity. Exhibits PPIase activity. Belongs to the FKBP-type PPIase family%3B Contains 1 PPIase FKBP-type domain%3B KEGG: vpa:VPA0545 peptidylprolyl isomerase gene gene3833 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03834 VSVS12_03835 VSVS12_03835 VSVS12_03835 907795 908412 - hypothetical protein gene gene3834 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03835 VSVS12_03836 VSVS12_03836 VSVS12_03836 908698 909291 + Outer membrane lipoprotein Omp16 like protein Belongs to the OmpA family. Pal subfamily%3B Contains 1 OmpA-like domain gene gene3835 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03836 VSVS12_03837 VSVS12_03837 VSVS12_03837 909402 910907 + Gluconokinase Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate%3B Belongs to the FGGY kinase family%3B KEGG: care:LT85_4982 gluconokinase gene gene3836 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03837 VSVS12_03838 VSVS12_03838 VSVS12_03838 911033 911263 - Uroporphyrinogen decarboxylase KEGG: shn:Shewana3_3722 uroporphyrinogen decarboxylase gene gene3837 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03838 VSVS12_03839 VSVS12_03839 VSVS12_03839 911665 911985 - UPF0265 protein Belongs to the UPF0265 family gene gene3838 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03839 VSVS12_03840 VSVS12_03840 VSVS12_03840 912176 912370 + hypothetical protein gene gene3839 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03840 VSVS12_03841 VSVS12_03841 VSVS12_03841 912404 913060 + UPF0502 protein Belongs to the UPF0502 family gene gene3840 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03841 VSVS12_03842 VSVS12_03842 VSVS12_03842 913053 913376 + UPF0213 protein Belongs to the UPF0213 family%3B Contains 1 GIY-YIG domain gene gene3841 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03842 VSVS12_03843 VSVS12_03843 VSVS12_03843 913479 914576 + Autoinducer 2-binding periplasmic protein LuxP Binds to an autoinducer molecule. This complex then interacts with the LuxQ sensor protein (By similarity)%3B Belongs to the bacterial solute-binding protein 2 family gene gene3842 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03843 VSVS12_03844 VSVS12_03844 luxQ luxQ 914576 917143 + Autoinducer 2 sensor kinase/phosphatase LuxQ At low cell density%2C in absence of autoinducer has a kinase activity%2C and autophosphorylates on a histidine residue. The phosphoryl group is then transferred to an aspartate residue in the response regulator domain. The phosphoryl group is transferred to LuxU%2C and ultimately to LuxO. At high cell density%2C in the presence of autoinducer%2C the kinase activity is inactivated%2C and the response regulator domain has a phosphatase activity (By similarity)%3B Contains 1 histidine kinase domain%3B Contains 1 response regulatory domain%3B KEGG: vtu:IX91_20040 two-component system%2C autoinducer 2 sensor kinase/phosphatase LuxQ%3B Histidine kinase gene gene3843 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03844 VSVS12_03845 VSVS12_03845 VSVS12_03845 917182 917847 - hypothetical protein gene gene3844 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03845 VSVS12_03846 VSVS12_03846 VSVS12_03846 917908 919464 - Glycerol-3-phosphate dehydrogenase Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family%3B KEGG: amc:MADE_1001195 glycerol-3-phosphate dehydrogenase gene gene3845 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03846 VSVS12_03847 VSVS12_03847 VSVS12_03847 919556 919765 - hypothetical protein gene gene3846 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03847 VSVS12_03848 VSVS12_03848 VSVS12_03848 920039 922219 - Inner membrane protein YccS Belongs to the YccS/YhfK family gene gene3847 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03848 VSVS12_03849 VSVS12_03849 helD helD 922419 924482 + DNA helicase Helicase IV catalyzes the unwinding of duplex DNA in the 3' to 5' direction with respect to the bound single strand in a reaction that is dependent upon the hydrolysis of ATP. Belongs to the helicase family. UvrD subfamily%3B Contains 1 uvrD-like helicase ATP-binding domain%3B KEGG: vvu:VV2_0122 DNA helicase IV gene gene3848 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03849 VSVS12_03850 VSVS12_03850 mgsA mgsA 924593 925048 - Methylglyoxal synthase Belongs to the methylglyoxal synthase family%3B KEGG: vch:VCA0711 methylglyoxal synthase gene gene3849 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03850 VSVS12_03851 VSVS12_03851 VSVS12_03851 925058 926059 - Periplasmic protein Upon binding a putative inducer it probably interacts with TorS and allows it to play a role in the induction of the torCAD operon for trimethylamine N-oxide reductase%3B Belongs to the bacterial solute-binding protein 2 family gene gene3850 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03851 VSVS12_03852 VSVS12_03852 torS torS 926140 929025 + Histidine kinase Member of the two-component regulatory system TorS/TorR involved in the anaerobic utilization of trimethylamine-N-oxide (TMAO). Detects the presence of TMAO in the medium and%2C in response%2C activates TorR via a four-step phosphorelay. When TMAO is removed%2C TorS can dephosphorylate TorR%2C probably by a reverse phosphorelay involving His-860 and Asp-733 (By similarity)%3B Contains 1 HAMP domain%3B Contains 1 histidine kinase domain%3B Contains 1 HPt domain%3B Contains 1 response regulatory domain%3B KEGG: vch:VCA0709 two-component system%2C OmpR family%2C sensor histidine kinase TorS gene gene3851 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03852 VSVS12_03853 VSVS12_03853 VSVS12_03853 929091 929717 - Alkenylglycerophosphocholine hydrolase Belongs to the TMEM86 family%3B KEGG: rno:690610 alkenylglycerophosphocholine/alkenylglycerophosphoethanolamine hydrolase gene gene3852 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03853 VSVS12_03854 VSVS12_03854 VSVS12_03854 929827 930324 + hypothetical protein gene gene3853 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03854 VSVS12_03855 VSVS12_03855 yqhD yqhD 930423 931577 - Alcohol dehydrogenase YqhD NADP-dependent ADH activity%3B Belongs to the iron-containing alcohol dehydrogenase family%3B KEGG: vha:VIBHAR_05947 NADP-dependent alcohol dehydrogenase%3B Acting on the CH-OH group of donors gene gene3854 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03855 VSVS12_03856 VSVS12_03856 VSVS12_03856 931971 933248 - Glucose-1-phosphate adenylyltransferase Catalyzes the synthesis of ADP-glucose%2C a sugar donor used in elongation reactions on alpha-glucans%3B Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family%3B KEGG: hit:NTHI1807 glucose-1-phosphate adenylyltransferase gene gene3855 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03856 VSVS12_03857 VSVS12_03857 VSVS12_03857 933538 935265 - Protein-N(pi)-phosphohistidine--sugar phosphotransferase The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS)%2C a major carbohydrate active -transport system%2C catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane%3B Contains 1 PTS EIIB type-2 domain%3B KEGG: vsp:VS_II1034 PTS system%2C fructose-specific IIB component gene gene3856 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03857 VSVS12_03858 VSVS12_03858 fruK fruK 935281 936252 - 1-phosphofructokinase Belongs to the carbohydrate kinase PfkB family%3B KEGG: vpa:VPA0812 1-phosphofructokinase gene gene3857 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03858 VSVS12_03859 VSVS12_03859 mtlA mtlA 936257 937399 - Protein-N(pi)-phosphohistidine--sugar phosphotransferase The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS)%2C a major carbohydrate active -transport system%2C catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in mannitol transport (By similarity)%3B Contains 1 PTS EIIA type-2 domain%3B KEGG: yfr:AW19_3321 PTS system%2C mannitol-specific IIA component gene gene3858 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03859 VSVS12_03860 VSVS12_03860 VSVS12_03860 937640 938620 + Catabolite repressor/activator Global transcriptional regulator%2C which plays an important role in the regulation of carbon metabolism%3B Contains 1 HTH lacI-type DNA-binding domain gene gene3859 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03860 VSVS12_03861 VSVS12_03861 VSVS12_03861 938679 940559 - Methyl-accepting chemotaxis protein PctC Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment%2C transduce a signal from the outside to the inside of the cell%2C and facilitate sensory adaptation through the variation of the level of methylation. Responds to L-His%2C L-Pro and GABA. Also involved in repellent responses to trichloroethylene (TCE)%2C chloroform and methylthiocyanate%3B Contains 1 cache domain%3B Contains 1 HAMP domain%3B Contains 1 methyl-accepting transducer domain gene gene3860 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03861 VSVS12_03862 VSVS12_03862 VSVS12_03862 940923 941441 - hypothetical protein gene gene3861 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03862 VSVS12_03863 VSVS12_03863 VSVS12_03863 941530 941904 - hypothetical protein gene gene3862 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03863 VSVS12_03864 VSVS12_03864 cobQ cobQ 942084 943562 + Adenosylcobyric acid synthase (glutamine-hydrolyzing) Catalyzes amidations at positions B%2C D%2C E%2C and G on adenosylcobyrinic A%2CC-diamide. NH(2) groups are provided by glutamine%2C and one molecule of ATP is hydrogenolyzed for each amidation%3B Belongs to the CobB/CobQ family. CobQ subfamily%3B Contains 1 GATase cobBQ-type domain%3B KEGG: vsp:VS_II0722 adenosylcobyric acid synthase gene gene3863 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03864 VSVS12_03865 VSVS12_03865 VSVS12_03865 943546 944334 + Molybdate-binding periplasmic protein Involved in the transport of molybdenum into the cell. Binds molybdate with high specificity and affinity. Belongs to the bacterial solute-binding protein ModA family gene gene3864 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03865 VSVS12_03866 VSVS12_03866 VSVS12_03866 944372 945064 + Molybdenum transport system permease protein Part of the binding-protein-dependent transport system for molybdenu%3B probably responsible for the translocation of the substrate across the membrane%3B Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily%3B Contains 1 ABC transmembrane type-1 domain gene gene3865 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03866 VSVS12_03867 VSVS12_03867 modC modC 945061 946173 + Molybdate-transporting ATPase Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system%3B Belongs to the ABC transporter superfamily. Molybdate importer (TC 3. A. 1. 8) family%3B Contains 1 ABC transporter domain%3B KEGG: vvu:VV2_0327 molybdate transport system ATP-binding protein gene gene3866 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03867 VSVS12_03868 VSVS12_03868 VSVS12_03868 946279 946716 - hypothetical protein gene gene3867 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03868 VSVS12_03869 VSVS12_03869 VSVS12_03869 946859 947836 + Virulence sensor protein BvgS Member of the two-component regulatory system BvgS/BvgA. Phosphorylates BvgA via a four-step phosphorelay in response to environmental signals (By similarity)%3B Contains 1 histidine kinase domain%3B Contains 1 HPt domain%3B Contains 1 PAC (PAS-associated C-terminal) domain%3B Contains 1 PAS (PER-ARNT-SIM) domain%3B Contains 1 response regulatory domain gene gene3868 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03869 VSVS12_03870 VSVS12_03870 VSVS12_03870 947876 948856 + hypothetical protein gene gene3869 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03870 VSVS12_03871 VSVS12_03871 VSVS12_03871 948905 950140 - Diguanylate cyclase VdcA Diguanylate cyclase (DGC) that catalyzes the synthesis of cyclic diguanylate (c-di-GMP) via the condensation of 2 GTP molecules. Is involved in the modulation of intracellular c-di-GMP levels. Cyclic-di-GMP is a second messenger which positively regulates biofilm formation and negatively regulates virulence in V. cholerae%2C and is proposed to play an important role in the transition from persistence in the environment to survival in the host. Overexpression of vdcA results in increased biofilm formation%2C and reduced motility and virulence%3B Contains 1 GGDEF domain%3B KEGG: vfi:VF_A0381 null%3B Phosphotransferases with a nitrogenous group as acceptor gene gene3870 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03871 VSVS12_03872 VSVS12_03872 VSVS12_03872 950398 950769 + hypothetical protein gene gene3871 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03872 VSVS12_03873 VSVS12_03873 VSVS12_03873 950861 951139 + hypothetical protein gene gene3872 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03873 VSVS12_03874 VSVS12_03874 VSVS12_03874 951433 952986 + NAD(P)(+) transhydrogenase (Re/Si-specific) May play a role in cell wall synthesis as L-alanine is an important constituent of the peptidoglycan layer%3B Belongs to the AlaDH/PNT family%3B KEGG: eco:b1603 NAD(P) transhydrogenase subunit alpha gene gene3873 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03874 VSVS12_03875 VSVS12_03875 pntB pntB 953002 954384 + NAD(P)(+) transhydrogenase (Re/Si-specific) The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane%3B Belongs to the PNT beta subunit family%3B KEGG: vch:VCA0564 NAD(P) transhydrogenase subunit beta gene gene3874 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03875 VSVS12_03876 VSVS12_03876 VSVS12_03876 954713 956131 + hypothetical protein gene gene3875 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03876 VSVS12_03877 VSVS12_03877 VSVS12_03877 956106 956765 + Transcriptional regulatory protein AfsQ1 Forms part of a two-component regulatory system AfsQ1/AfsQ2 involved in secondary metabolism. Contains 1 OmpR/PhoB-type DNA-binding domain%3B Contains 1 response regulatory domain gene gene3876 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03877 VSVS12_03878 VSVS12_03878 VSVS12_03878 956762 957640 + hypothetical protein gene gene3877 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03878 VSVS12_03879 VSVS12_03879 VSVS12_03879 957700 958833 + hypothetical protein gene gene3878 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03879 VSVS12_03880 VSVS12_03880 VSVS12_03880 958887 959045 + UPF0181 protein Belongs to the UPF0181 family gene gene3879 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03880 VSVS12_03881 VSVS12_03881 VSVS12_03881 959615 959968 + hypothetical protein gene gene3880 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03881 VSVS12_03882 VSVS12_03882 VSVS12_03882 960021 960581 - hypothetical protein gene gene3881 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03882 VSVS12_03883 VSVS12_03883 VSVS12_03883 960644 960913 + hypothetical protein gene gene3882 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03883 VSVS12_03884 VSVS12_03884 VSVS12_03884 961032 961169 + hypothetical protein gene gene3883 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03884 VSVS12_03885 VSVS12_03885 VSVS12_03885 961591 961926 - hypothetical protein gene gene3884 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03885 VSVS12_03886 VSVS12_03886 VSVS12_03886 962036 963175 + Replication-associated protein G2P Isoform G2P plays an essential role in viral DNA replication. Binds the origin of replication and cleaves the dsDNA replicative form I (RFI) and becomes covalently bound to it via phosphotyrosine bond%2C generating the dsDNA replicative form II (RFII). In turn%2C viral DNA replication initiates at the 3'-OH of the cleavage site. After one round of rolling circle synthesis%2C protein G2P is linked to the newly synthesized ssDNA and joins the ends of the displaced strand to generate a circular single- stranded molecule ready to be packed into a virion (By similarity)%3B Isoform G10P protein binds to double-stranded DNA and prevents hydrolysis by nucleases. Additionally%2C G10P is an inhibitor of DNA replication and may have a role in the transition from semiconservative replicative form DNA replication to single- stranded DNA synthesis in the life cycle (By similarity)%3B Belongs to the inovirus G2P protein family gene gene3885 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03886 VSVS12_03887 VSVS12_03887 VSVS12_03887 963201 963485 + DNA-Binding protein G5P Binds to DNA in a highly cooperative manner without pronounced sequence specificity. During synthesis of the single- stranded (progeny) viral DNA%2C prevents the conversion into the double-stranded replicative form. G5P is displaced by the capsid protein G8P during phage assembly on the inner bacterial membrane (By similarity)%3B Belongs to the inovirus G5P protein family gene gene3886 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03887 VSVS12_03888 VSVS12_03888 VSVS12_03888 963512 964192 + hypothetical protein gene gene3887 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03888 VSVS12_03889 VSVS12_03889 VSVS12_03889 964194 964400 + hypothetical protein gene gene3888 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03889 VSVS12_03890 VSVS12_03890 VSVS12_03890 964397 964594 + hypothetical protein gene gene3889 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03890 VSVS12_03891 VSVS12_03891 VSVS12_03891 964533 964793 + hypothetical protein gene gene3890 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03891 VSVS12_03892 VSVS12_03892 VSVS12_03892 964887 965024 + hypothetical protein gene gene3891 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03892 VSVS12_03893 VSVS12_03893 VSVS12_03893 965446 965781 - hypothetical protein gene gene3892 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03893 VSVS12_03894 VSVS12_03894 VSVS12_03894 965891 967030 + Replication-associated protein G2P Isoform G2P plays an essential role in viral DNA replication. Binds the origin of replication and cleaves the dsDNA replicative form I (RFI) and becomes covalently bound to it via phosphotyrosine bond%2C generating the dsDNA replicative form II (RFII). In turn%2C viral DNA replication initiates at the 3'-OH of the cleavage site. After one round of rolling circle synthesis%2C protein G2P is linked to the newly synthesized ssDNA and joins the ends of the displaced strand to generate a circular single- stranded molecule ready to be packed into a virion (By similarity)%3B Isoform G10P protein binds to double-stranded DNA and prevents hydrolysis by nucleases. Additionally%2C G10P is an inhibitor of DNA replication and may have a role in the transition from semiconservative replicative form DNA replication to single- stranded DNA synthesis in the life cycle (By similarity)%3B Belongs to the inovirus G2P protein family gene gene3893 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03894 VSVS12_03895 VSVS12_03895 VSVS12_03895 967056 967340 + DNA-Binding protein G5P Binds to DNA in a highly cooperative manner without pronounced sequence specificity. During synthesis of the single- stranded (progeny) viral DNA%2C prevents the conversion into the double-stranded replicative form. G5P is displaced by the capsid protein G8P during phage assembly on the inner bacterial membrane (By similarity)%3B Belongs to the inovirus G5P protein family gene gene3894 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03895 VSVS12_03896 VSVS12_03896 VSVS12_03896 967367 968047 + hypothetical protein gene gene3895 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03896 VSVS12_03897 VSVS12_03897 VSVS12_03897 968049 968255 + hypothetical protein gene gene3896 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03897 VSVS12_03898 VSVS12_03898 VSVS12_03898 968252 968449 + hypothetical protein gene gene3897 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03898 VSVS12_03899 VSVS12_03899 VSVS12_03899 969237 969626 - hypothetical protein gene gene3898 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03899 VSVS12_03900 VSVS12_03900 VSVS12_03900 970121 970354 + hypothetical protein gene gene3899 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03900 VSVS12_03901 VSVS12_03901 VSVS12_03901 970424 970705 + hypothetical protein gene gene3900 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03901 VSVS12_03902 VSVS12_03902 VSVS12_03902 970920 971231 - uncharacterized protein Belongs to the SUI1 family gene gene3901 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03902 VSVS12_03903 VSVS12_03903 VSVS12_03903 971234 971578 - hypothetical protein gene gene3902 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03903 VSVS12_03904 VSVS12_03904 VSVS12_03904 971707 972663 + hypothetical protein gene gene3903 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03904 VSVS12_03905 VSVS12_03905 VSVS12_03905 972690 973682 - D-alanine--D-alanine ligase Cell wall formation%3B Belongs to the D-alanine--D-alanine ligase family%3B Contains 1 ATP-grasp domain%3B KEGG: vch:VCA0572 D-alanine-D-alanine ligase gene gene3904 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03905 VSVS12_03906 VSVS12_03906 VSVS12_03906 973836 974420 - hypothetical protein gene gene3905 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03906 VSVS12_03907 VSVS12_03907 VSVS12_03907 974580 977279 + Protein lysine acetyltransferase Pat Acetylates and inactivates the acetyl-CoA synthase (Acs). Can also acetylate other central metabolic enzymes in response to environmental changes%3B In the N-terminal sectio%3B belongs to the acetate CoA ligase alpha subunit family%3B In the central sectio%3B belongs to the acetate CoA ligase beta subunit family%3B Contains 1 ATP-grasp domain%3B Contains 1 N-acetyltransferase domain gene gene3906 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03907 VSVS12_03908 VSVS12_03908 VSVS12_03908 977425 978312 - putative HTH-type transcriptional regulator Contains 1 HTH lysR-type DNA-binding domain gene gene3907 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03908 VSVS12_03909 VSVS12_03909 VSVS12_03909 978828 979079 - hypothetical protein gene gene3908 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03909 VSVS12_03910 VSVS12_03910 VSVS12_03910 979063 980787 - HTH-type transcriptional regulator SgrR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain%3B Contains 1 HTH marR-type DNA-binding domain gene gene3909 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03910 VSVS12_03911 VSVS12_03911 VSVS12_03911 980857 981090 - hypothetical protein gene gene3910 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03911 VSVS12_03912 VSVS12_03912 menI menI 981102 981560 - 1%2C4-dihydroxy-2-naphthoyl-CoA hydrolase Required for optimal enterobactin synthesis. Acts as a proofreading enzyme that prevents EntB misacylation by hydrolyzing the thioester bound existing between EntB and wrongly charged molecules%3B Belongs to the thioesterase PaaI family%3B KEGG: dji:CH75_22165 1%2C4-dihydroxy-2-naphthoyl-CoA hydrolase gene gene3911 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03912 VSVS12_03913 VSVS12_03913 VSVS12_03913 981642 982427 + Metalloendopeptidase OMA1%2C mitochondrial Metalloprotease that is part of the quality control system in the inner membrane of mitochondria. Following stress conditions that induce loss of mitochondrial membrane potential%2C mediates cleavage of OPA1 at S1 position%2C leading to OPA1 inactivation and negative regulation of mitochondrial fusion. May also cleave UQCC3 under these conditions. Its role in mitochondrial quality control is essential for regulating lipid metabolism as well as to maintain body temperature and energy expenditure under cold-stress conditions%3B Belongs to the peptidase M48 family gene gene3912 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03913 VSVS12_03914 VSVS12_03914 VSVS12_03914 982551 983579 - hypothetical protein gene gene3913 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03914 VSVS12_03915 VSVS12_03915 VSVS12_03915 983898 984455 + Phosphonoacetate hydrolase KEGG: vvu:VV2_0245 phosphonoacetate hydrolase gene gene3914 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03915 VSVS12_03916 VSVS12_03916 VSVS12_03916 984526 986076 - Aerotaxis receptor Signal transducer for aerotaxis. The aerotactic response is the accumulation of cells around air bubbles. The nature of the sensory stimulus detected by this protein is the proton motive force or cellular redox state. It uses a FAD prosthetic group as a redox sensor to monitor oxygen levels%3B Contains 1 methyl-accepting transducer domain%3B Contains 1 PAC (PAS-associated C-terminal) domain%3B Contains 1 PAS (PER-ARNT-SIM) domain gene gene3915 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03916 VSVS12_03917 VSVS12_03917 VSVS12_03917 986285 986476 - hypothetical protein gene gene3916 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03917 VSVS12_03918 VSVS12_03918 VSVS12_03918 986778 987722 - Inner membrane protein alx Belongs to the TerC family gene gene3917 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03918 VSVS12_03919 VSVS12_03919 VSVS12_03919 987995 988090 - hypothetical protein gene gene3918 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03919 VSVS12_03920 VSVS12_03920 VSVS12_03920 988173 989903 - 5'-nucleotidase Hydrolyzes extracellular nucleotides into membrane permeable nucleosides. Belongs to the 5'-nucleotidase family%3B KEGG: vtu:IX91_19805 5'-nucleotidase gene gene3919 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03920 VSVS12_03921 VSVS12_03921 VSVS12_03921 990059 991690 + uncharacterized protein Contains 1 Toprim domain gene gene3920 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03921 VSVS12_03922 VSVS12_03922 VSVS12_03922 991798 992286 - Inner membrane protein YcdZ To E. coli YahC gene gene3921 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03922 VSVS12_03923 VSVS12_03923 VSVS12_03923 992511 993416 - putative RuBisCO transcriptional regulator Trans-acting transcriptional regulator of RuBisCO genes (rbcL and rbcS) expression%3B Contains 1 HTH lysR-type DNA-binding domain gene gene3922 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03923 VSVS12_03924 VSVS12_03924 VSVS12_03924 993657 995102 + putative formate transporter Involved in the bidirectional transport of formate%3B Belongs to the FNT transporter (TC 2. A. 44) family gene gene3923 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03924 VSVS12_03925 VSVS12_03925 VSVS12_03925 995190 995759 - UPF0312 protein Belongs to the UPF0312 family. Type 1 subfamily gene gene3924 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03925 VSVS12_03926 VSVS12_03926 VSVS12_03926 995756 996295 - Cytochrome b561 like protein Belongs to the cytochrome b561 family gene gene3925 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03926 VSVS12_03927 VSVS12_03927 VSVS12_03927 996478 997686 + hypothetical protein gene gene3926 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03927 VSVS12_03928 VSVS12_03928 VSVS12_03928 997773 998024 - hypothetical protein gene gene3927 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03928 VSVS12_03929 VSVS12_03929 VSVS12_03929 998129 998764 + hypothetical protein gene gene3928 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03929 VSVS12_03930 VSVS12_03930 VSVS12_03930 999198 999992 + hypothetical protein gene gene3929 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03930 VSVS12_03931 VSVS12_03931 VSVS12_03931 1000232 1001599 + putative anaerobic C4-dicarboxylate transporter DcuC Responsible for the transport of C4-dicarboxylates during anaerobic growth%3B Belongs to the DcuC/DcuD transporter (TC 2. A. 61) family gene gene3930 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03931 VSVS12_03932 VSVS12_03932 VSVS12_03932 1001694 1002326 - Chemotaxis response regulator protein-glutamate methylesterase Involved in the modulation of the chemotaxis syste%3B catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR%3B Contains 1 cheB-type methylesterase domain%3B Contains 1 response regulatory domain gene gene3931 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03932 VSVS12_03933 VSVS12_03933 narQ narQ 1002313 1004046 - Histidine kinase Acts as a sensor for nitrate/nitrite and transduces signal of nitrate/nitrite availability to the NarL/NarP proteins. NarQ probably activates NarL and NarP by phosphorylation. NarQ probably negatively regulates the NarL protein by dephosphorylation. Contains 1 HAMP domain%3B Contains 1 histidine kinase domain%3B KEGG: vvu:VV2_0719 two-component system%2C NarL family%2C nitrate/nitrite sensor histidine kinase NarQ gene gene3932 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03933 VSVS12_03934 VSVS12_03934 VSVS12_03934 1004285 1004770 + Ferredoxin-type protein Involved in electron transfer%3B Contains 3 4Fe-4S ferredoxin-type domains gene gene3933 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03934 VSVS12_03935 VSVS12_03935 VSVS12_03935 1004797 1005117 + hypothetical protein gene gene3934 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03935 VSVS12_03936 VSVS12_03936 napA napA 1005114 1007603 + Nitrate reductase Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC%2C thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism%3B Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. NasA/NapA/NarB subfamily%3B Contains 1 4Fe-4S Mo/W bis-MGD-type domain%3B KEGG: vch:VCA0678 periplasmic nitrate reductase NapA gene gene3935 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03936 VSVS12_03937 VSVS12_03937 VSVS12_03937 1007666 1008121 + Periplasmic nitrate reductase%2C electron transfer subunit Electron transfer subunit of the periplasmic nitrate reductase complex NapAB. Receives electrons from the membrane- anchored tetraheme c-type NapC protein and transfers these to NapA subunit%2C thus allowing electron flow between membrane and periplasm. Essential for periplasmic nitrate reduction with nitrate as the terminal electron acceptor%3B Belongs to the NapB family gene gene3936 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03937 VSVS12_03938 VSVS12_03938 VSVS12_03938 1008153 1008731 + Cytochrome c-type protein Mediates electron flow from quinones to the NapAB complex gene gene3937 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03938 VSVS12_03939 VSVS12_03939 VSVS12_03939 1008741 1008878 + hypothetical protein gene gene3938 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03939 VSVS12_03940 VSVS12_03940 VSVS12_03940 1009217 1009456 - hypothetical protein gene gene3939 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03940 VSVS12_03941 VSVS12_03941 VSVS12_03941 1009758 1011698 + Hybrid signal transduction histidine kinase Acts as a receptor histidine kinase for a signal transduction pathway. This protein undergoes an ATP-dependent autophosphorylation at a conserved histidine residue in the kinase core%2C and a phosphoryl group is then transferred to a conserved aspartate residue in the receiver domain (By similarity)%3B Belongs to the protein kinase superfamily. Ser/Thr protein kinase family%3B Contains 1 GAF domain%3B Contains 1 histidine kinase domain%3B Contains 1 protein kinase domain%3B Contains 1 response regulatory domain%3B Contains 1 TPR repeat%3B KEGG: ava:Ava_4779 null%3B Phosphotransferases with a nitrogenous group as acceptor%3B overlaps another CDS with the same product name gene gene3940 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03941 VSVS12_03942 VSVS12_03942 VSVS12_03942 1011650 1012969 + Hybrid signal transduction histidine kinase Acts as a receptor histidine kinase for a signal transduction pathway. This protein undergoes an ATP-dependent autophosphorylation at a conserved histidine residue in the kinase core%2C and a phosphoryl group is then transferred to a conserved aspartate residue in the receiver domain (By similarity)%3B Contains 1 histidine kinase domain%3B Contains 2 response regulatory domains%3B KEGG: vfi:VF_A1016 null%3B Phosphotransferases with a nitrogenous group as acceptor%3B overlaps another CDS with the same product name gene gene3941 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03942 VSVS12_03943 VSVS12_03943 VSVS12_03943 1012983 1013468 + hypothetical protein gene gene3942 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03943 VSVS12_03944 VSVS12_03944 VSVS12_03944 1013471 1014577 + hypothetical protein gene gene3943 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03944 VSVS12_03945 VSVS12_03945 VSVS12_03945 1015291 1016499 + hypothetical protein gene gene3944 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03945 VSVS12_03946 VSVS12_03946 VSVS12_03946 1016680 1017123 + hypothetical protein gene gene3945 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03946 VSVS12_03947 VSVS12_03947 VSVS12_03947 1017170 1017601 + hypothetical protein gene gene3946 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03947 VSVS12_03948 VSVS12_03948 VSVS12_03948 1017598 1018293 + hypothetical protein gene gene3947 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03948 VSVS12_03949 VSVS12_03949 VSVS12_03949 1018314 1020740 + hypothetical protein gene gene3948 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03949 VSVS12_03950 VSVS12_03950 aslA aslA 1020802 1022349 - Arylsulfatase Displays arylsulfatase activity with pseudosubstrates at acidic pH%2C such as p-nitrocatechol sulfate%3B Belongs to the sulfatase family%3B KEGG: shd:SUTH_00506 arylsulfatase gene gene3949 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03950 VSVS12_03951 VSVS12_03951 VSVS12_03951 1022448 1023383 - hypothetical protein gene gene3950 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03951 VSVS12_03952 VSVS12_03952 VSVS12_03952 1023441 1024808 - Anaerobic sulfatase-maturating enzyme Involved in 'Ser-type' sulfatase maturation under anaerobic conditions. Catalyzes the post-translational modification of serine ('Ser-72' in the arylsulfatase AtsA) into 3-oxoalanine (also known as C(alpha)-formylglycine (FGly))%2C by a free radical chemical mechanism initiated via the reductive cleavage of S-adenosyl-L-methionine (SAM) (By similarity)%3B Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family gene gene3951 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03952 VSVS12_03953 VSVS12_03953 VSVS12_03953 1025042 1026250 - hypothetical protein gene gene3952 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03953 VSVS12_03954 VSVS12_03954 VSVS12_03954 1026424 1027431 - Putative beta-lactamase HcpC May hydrolyze 6-aminopenicillinic acid and 7- aminocephalosporanic acid (ACA) derivatives%3B Belongs to the hcp beta-lactamase family%3B Contains 7 TPR repeats gene gene3953 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03954 VSVS12_03955 VSVS12_03955 VSVS12_03955 1028101 1028193 - hypothetical protein gene gene3954 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03955 VSVS12_03956 VSVS12_03956 VSVS12_03956 1028267 1030927 + Cyclic-guanylate-specific phosphodiesterase Overexpression reduces biofilm formation. Cyclic-di-GMP is a second messenger which controls cell surface-associated traits in bacteria%3B Contains 1 EAL domain%3B KEGG: spe:Spro_4742 cyclic di-GMP phosphodiesterase Gmr gene gene3955 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03956 VSVS12_03957 VSVS12_03957 VSVS12_03957 1031067 1032524 + Membrane-bound protease Protease that cleaves its substrates preferentially near hydrophobic or aromatic amino acid residues%3B Belongs to the peptidase S14 family gene gene3956 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03957 VSVS12_03958 VSVS12_03958 VSVS12_03958 1032534 1033313 + Stomatin like protein Belongs to the band 7/mec-2 family%3B KEGG: bpn:BPEN_084 membrane protease subunit HflK%3B Acting on peptide bonds (peptidases) gene gene3957 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03958 VSVS12_03959 VSVS12_03959 VSVS12_03959 1033473 1034468 - hypothetical protein gene gene3958 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03959 VSVS12_03960 VSVS12_03960 VSVS12_03960 1034578 1036110 - uncharacterized protein To H. influenzae HI_0594%3B To B. subtilis YcgA gene gene3959 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03960 VSVS12_03961 VSVS12_03961 VSVS12_03961 1036490 1036732 + hypothetical protein gene gene3960 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03961 VSVS12_03962 VSVS12_03962 VSVS12_03962 1036833 1038083 + RNA helicase ATP-dependent rRNA helicase required for pre-ribosomal RNA processing. Involved in the maturation of the 35S-pre-rRNA and to its cleavage to mature 18S rRNA%3B Belongs to the DEAD box helicase family. DDX47/RRP3 subfamily%3B Contains 1 helicase ATP-binding domain%3B Contains 1 helicase C-terminal domain%3B KEGG: mvs:MVIS_3304 ATP-dependent RNA helicase RhlE gene gene3961 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03962 VSVS12_03963 VSVS12_03963 VSVS12_03963 1038224 1040068 - hypothetical protein gene gene3962 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03963 VSVS12_03964 VSVS12_03964 VSVS12_03964 1040073 1042427 - hypothetical protein gene gene3963 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03964 VSVS12_03965 VSVS12_03965 VSVS12_03965 1042825 1044822 + putative protease YrrO Belongs to the peptidase U32 family%3B KEGG: vpa:VPA1670 putative protease%3B Acting on peptide bonds (peptidases) gene gene3964 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03965 VSVS12_03966 VSVS12_03966 VSVS12_03966 1044935 1046218 - Branched-chain amino acid transport system 2 carrier protein Component of the LIV-II transport system for branched- chain amino acids. BraB is specific for isoleucine%2C leucine and valine. The LIV-II transport system is coupled to sodium and lithium ions. Belongs to the branched chain amino acid transporter family gene gene3965 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03966 VSVS12_03967 VSVS12_03967 VSVS12_03967 1046355 1046489 - hypothetical protein gene gene3966 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03967 VSVS12_03968 VSVS12_03968 VSVS12_03968 1046744 1048732 - UvrABC system protein The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site%2C the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix%2C facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found%2C the DNA wraps around the other UvrB subunit that will check the other stand for damage%3B Belongs to the UvrB family%3B Contains 1 helicase ATP-binding domain%3B Contains 1 helicase C-terminal domain%3B Contains 1 UVR domain gene gene3967 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03968 VSVS12_03969 VSVS12_03969 VSVS12_03969 1049082 1051412 + hypothetical protein gene gene3968 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03969 VSVS12_03970 VSVS12_03970 VSVS12_03970 1051530 1052138 - hypothetical protein gene gene3969 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03970 VSVS12_03971 VSVS12_03971 VSVS12_03971 1052506 1054470 + DNA helicase Involved in the RecF recombination pathwa%3B its gene expression is under the regulation of the SOS system. It is a DNA helicase%3B Belongs to the helicase family. RecQ subfamily%3B Contains 1 helicase ATP-binding domain%3B Contains 1 helicase C-terminal domain%3B Contains 1 HRDC domain%3B KEGG: pfv:Psefu_4024 ATP-dependent DNA helicase RecQ gene gene3970 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03971 VSVS12_03972 VSVS12_03972 katG katG 1054557 1056737 - Catalase peroxidase Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity%3B Belongs to the peroxidase family. Peroxidase/catalase subfamily%3B KEGG: eca:ECA1909 catalase-peroxidase gene gene3971 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03972 VSVS12_03973 VSVS12_03973 VSVS12_03973 1056988 1058181 - Acetate kinase Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction%3B Belongs to the acetokinase family%3B KEGG: vch:VCA0235 acetate kinase gene gene3972 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03973 VSVS12_03974 VSVS12_03974 VSVS12_03974 1058760 1060769 - Heme transporter BhuA Heme transporter playing an important role in stationary-phase iron acquisition and required for maintenance of chronic infection in mice%3B Belongs to the TonB-dependent receptor family gene gene3973 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03974 VSVS12_03975 VSVS12_03975 VSVS12_03975 1060885 1061865 + HTH-type transcriptional activator RhaS Activates expression of the rhaBAD and rhaT operons%3B Contains 2 HTH araC/xylS-type DNA-binding domains gene gene3974 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03975 VSVS12_03976 VSVS12_03976 VSVS12_03976 1061934 1062323 + HTH-type transcriptional regulator CueR Regulates the transcription of the copA and cueO genes. It detects cytoplasmic copper stress and activates transcription in response to increasing copper concentrations (By similarity)%3B Contains 1 HTH merR-type DNA-binding domain gene gene3975 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03976 VSVS12_03977 VSVS12_03977 rbsA rbsA 1062428 1063183 - Monosaccharide-transporting ATPase Part of a binding-protein-dependent transport system for arginine. Probably responsible for energy coupling to the transport system%3B Belongs to the ABC transporter superfamily%3B Contains 1 ABC transporter domain%3B KEGG: sod:Sant_0208 ribose transport system ATP-binding protein gene gene3976 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03977 VSVS12_03978 VSVS12_03978 VSVS12_03978 1063191 1064141 - Ferric anguibactin transport system permease protein FatC Part of the binding-protein-dependent transport system for ferric anguibactin. Probably responsible for the translocation of the substrate across the membrane. Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily gene gene3977 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03978 VSVS12_03979 VSVS12_03979 VSVS12_03979 1064131 1065066 - putative ABC transporter permease protein YclN Probably part of an ABC transporter complex. Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily gene gene3978 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03979 VSVS12_03980 VSVS12_03980 VSVS12_03980 1065132 1066040 - putative ABC transporter solute-binding protein YclQ Probably part of an ABC transporter complex. Belongs to the bacterial solute-binding protein 8 family%3B Contains 1 Fe/B12 periplasmic-binding domain gene gene3979 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03980 VSVS12_03981 VSVS12_03981 VSVS12_03981 1066305 1066877 - hypothetical protein gene gene3980 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03981 VSVS12_03982 VSVS12_03982 VSVS12_03982 1067216 1068994 + Cyclic-guanylate-specific phosphodiesterase Contains 1 EAL domain%3B Contains 1 GGDEF domain%3B Contains 2 PAC (PAS-associated C-terminal) domains%3B Contains 2 PAS (PER-ARNT-SIM) domains%3B KEGG: bvi:Bcep1808_4032 cyclic di-GMP phosphodiesterase Gmr gene gene3981 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03982 VSVS12_03983 VSVS12_03983 VSVS12_03983 1069038 1070681 - Dipeptide transport ATP-binding protein Part of the binding-protein-dependent transport system for dipeptides. Probably responsible for energy coupling to the transport system (By similarity)%3B Belongs to the ABC transporter superfamily%3B Contains 1 ABC transporter domain gene gene3982 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03983 VSVS12_03984 VSVS12_03984 VSVS12_03984 1070681 1071784 - Inner membrane ABC transporter permease protein Probably part of a binding-protein-dependent transport system. Probably responsible for the translocation of the substrate across the membrane. Belongs to the binding-protein-dependent transport system permease family. OppBC subfamily%3B Contains 1 ABC transmembrane type-1 domain gene gene3983 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03984 VSVS12_03985 VSVS12_03985 VSVS12_03985 1071784 1072872 - Inner membrane ABC transporter permease protein Probably part of a binding-protein-dependent transport system. Probably responsible for the translocation of the substrate across the membrane (By similarity)%3B Belongs to the binding-protein-dependent transport system permease family. OppBC subfamily%3B Contains 1 ABC transmembrane type-1 domain gene gene3984 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03985 VSVS12_03986 VSVS12_03986 VSVS12_03986 1072883 1074700 - uncharacterized protein To H. influenzae HbpA gene gene3985 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03986 VSVS12_03987 VSVS12_03987 VSVS12_03987 1074953 1075471 - hypothetical protein gene gene3986 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03987 VSVS12_03988 VSVS12_03988 ldhA ldhA 1075905 1076900 + D-lactate dehydrogenase Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family%3B KEGG: vpa:VPA0144 D-lactate dehydrogenase gene gene3987 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03988 VSVS12_03989 VSVS12_03989 VSVS12_03989 1076971 1079331 - Endopeptidase La Belongs to the peptidase S16 family%3B KEGG: sat:SYN_01156 ATP-dependent Lon protease gene gene3988 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03989 VSVS12_03990 VSVS12_03990 VSVS12_03990 1079561 1080055 + hypothetical protein gene gene3989 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03990 VSVS12_03991 VSVS12_03991 VSVS12_03991 1080091 1080990 - HTH-type transcriptional activator AllS Positive regulator essential for the expression of AllD operon. Binds to the AllD promoter (By similarity)%3B Contains 1 HTH lysR-type DNA-binding domain gene gene3990 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03991 VSVS12_03992 VSVS12_03992 VSVS12_03992 1081396 1081746 - hypothetical protein gene gene3991 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03992 VSVS12_03993 VSVS12_03993 VSVS12_03993 1081883 1082098 - hypothetical protein gene gene3992 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03993 VSVS12_03994 VSVS12_03994 VSVS12_03994 1082470 1082934 - uncharacterized protein gene gene3993 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03994 VSVS12_03995 VSVS12_03995 VSVS12_03995 1083279 1083611 + Protein translocase subunit SecA Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane%2C serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane%3B Belongs to the SecA family gene gene3994 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03995 VSVS12_03996 VSVS12_03996 VSVS12_03996 1083721 1084347 - uncharacterized protein Contains 1 HD domain gene gene3995 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03996 VSVS12_03997 VSVS12_03997 VSVS12_03997 1084571 1084819 - hypothetical protein gene gene3996 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03997 VSVS12_03998 VSVS12_03998 VSVS12_03998 1084989 1085399 - hypothetical protein gene gene3997 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03998 VSVS12_03999 VSVS12_03999 VSVS12_03999 1085525 1085917 + hypothetical protein gene gene3998 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_03999 VSVS12_04000 VSVS12_04000 VSVS12_04000 1085967 1086704 - UPF0721 transmembrane protein Belongs to the UPF0721 family gene gene3999 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04000 VSVS12_04001 VSVS12_04001 VSVS12_04001 1086811 1088019 + hypothetical protein gene gene4000 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04001 VSVS12_04002 VSVS12_04002 VSVS12_04002 1087977 1088111 - hypothetical protein gene gene4001 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04002 VSVS12_04003 VSVS12_04003 VSVS12_04003 1088421 1089395 + hypothetical protein gene gene4002 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04003 VSVS12_04004 VSVS12_04004 VSVS12_04004 1089412 1090458 + 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation%3B Belongs to the vitamin-B12 independent methionine synthase family%3B KEGG: pwa:Pecwa_1367 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase gene gene4003 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04004 VSVS12_04005 VSVS12_04005 VSVS12_04005 1090545 1090805 - hypothetical protein gene gene4004 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04005 VSVS12_04006 VSVS12_04006 VSVS12_04006 1090802 1091110 - hypothetical protein gene gene4005 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04006 VSVS12_04007 VSVS12_04007 VSVS12_04007 1091401 1092369 + Transposase for insertion sequence element IS4351 Required for the transposition of the insertion element%3B Belongs to the transposase IS30 family%3B Contains 1 integrase catalytic domain gene gene4006 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04007 VSVS12_04008 VSVS12_04008 VSVS12_04008 1092400 1092765 - hypothetical protein gene gene4007 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04008 VSVS12_04009 VSVS12_04009 VSVS12_04009 1092919 1093584 - hypothetical protein gene gene4008 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04009 VSVS12_04010 VSVS12_04010 VSVS12_04010 1093844 1094011 + hypothetical protein gene gene4009 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04010 VSVS12_04011 VSVS12_04011 VSVS12_04011 1094292 1094798 - hypothetical protein gene gene4010 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04011 VSVS12_04012 VSVS12_04012 VSVS12_04012 1094959 1095297 - hypothetical protein gene gene4011 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04012 VSVS12_04013 VSVS12_04013 VSVS12_04013 1095434 1096078 - hypothetical protein gene gene4012 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04013 VSVS12_04014 VSVS12_04014 VSVS12_04014 1096424 1096558 - hypothetical protein gene gene4013 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04014 VSVS12_04015 VSVS12_04015 VSVS12_04015 1096761 1097237 - hypothetical protein gene gene4014 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04015 VSVS12_04016 VSVS12_04016 VSVS12_04016 1097374 1098093 - hypothetical protein gene gene4015 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04016 VSVS12_04017 VSVS12_04017 VSVS12_04017 1098253 1098600 - hypothetical protein gene gene4016 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04017 VSVS12_04018 VSVS12_04018 VSVS12_04018 1098809 1099267 - hypothetical protein gene gene4017 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04018 VSVS12_04019 VSVS12_04019 VSVS12_04019 1099416 1099787 - hypothetical protein gene gene4018 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04019 VSVS12_04020 VSVS12_04020 VSVS12_04020 1099979 1100332 - hypothetical protein gene gene4019 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04020 VSVS12_04021 VSVS12_04021 VSVS12_04021 1101832 1103163 + Prophage CP4-57 integrase Integrase is necessary for integration of the phage into the host genome by site-specific recombination. In conjunction with excisionase%2C integrase is also necessary for excision of the prophage from the host genome. Belongs to the 'phage' integrase family gene gene4020 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04021 VSVS12_04022 VSVS12_04022 VSVS12_04022 1103236 1103742 + hypothetical protein gene gene4021 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04022 VSVS12_04023 VSVS12_04023 VSVS12_04023 1103764 1104525 + hypothetical protein gene gene4022 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04023 VSVS12_04024 VSVS12_04024 VSVS12_04024 1104951 1110689 - putative ATP-dependent helicase Belongs to the DNA2/NAM7 helicase family gene gene4023 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04024 VSVS12_04025 VSVS12_04025 VSVS12_04025 1110759 1110887 + hypothetical protein gene gene4024 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04025 VSVS12_04026 VSVS12_04026 VSVS12_04026 1110996 1112438 - hypothetical protein gene gene4025 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04026 VSVS12_04027 VSVS12_04027 VSVS12_04027 1113205 1114413 + hypothetical protein gene gene4026 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04027 VSVS12_04028 VSVS12_04028 VSVS12_04028 1114382 1116049 - hypothetical protein gene gene4027 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04028 VSVS12_04029 VSVS12_04029 VSVS12_04029 1116257 1117465 - hypothetical protein gene gene4028 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04029 VSVS12_04030 VSVS12_04030 VSVS12_04030 1117606 1118814 - hypothetical protein gene gene4029 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04030 VSVS12_04031 VSVS12_04031 VSVS12_04031 1119287 1119928 - hypothetical protein gene gene4030 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04031 VSVS12_04032 VSVS12_04032 VSVS12_04032 1119925 1121133 - hypothetical protein gene gene4031 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04032 VSVS12_04033 VSVS12_04033 VSVS12_04033 1121237 1121389 - hypothetical protein gene gene4032 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04033 VSVS12_04034 VSVS12_04034 VSVS12_04034 1122119 1122445 - hypothetical protein gene gene4033 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04034 VSVS12_04035 VSVS12_04035 VSVS12_04035 1123297 1123470 + hypothetical protein gene gene4034 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04035 VSVS12_04036 VSVS12_04036 VSVS12_04036 1123732 1124088 - hypothetical protein gene gene4035 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04036 VSVS12_04037 VSVS12_04037 VSVS12_04037 1124541 1124804 + hypothetical protein gene gene4036 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04037 VSVS12_04038 VSVS12_04038 VSVS12_04038 1125595 1126248 - hypothetical protein gene gene4037 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04038 VSVS12_04039 VSVS12_04039 VSVS12_04039 1126494 1126637 + hypothetical protein gene gene4038 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04039 VSVS12_04040 VSVS12_04040 VSVS12_04040 1126987 1127340 - hypothetical protein gene gene4039 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04040 VSVS12_04041 VSVS12_04041 VSVS12_04041 1127501 1128007 - Acetyltransferase Renders tabtoxin-producing pathogens tolerant to their own phytotoxins%3B Contains 1 N-acetyltransferase domain%3B KEGG: eca:ECA0954 null%3B Transferring groups other than amino-acyl groups gene gene4040 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04041 VSVS12_04042 VSVS12_04042 VSVS12_04042 1128895 1129005 + hypothetical protein gene gene4041 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04042 VSVS12_04043 VSVS12_04043 VSVS12_04043 1129166 1129585 - hypothetical protein gene gene4042 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04043 VSVS12_04044 VSVS12_04044 VSVS12_04044 1129585 1130046 - hypothetical protein gene gene4043 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04044 VSVS12_04045 VSVS12_04045 VSVS12_04045 1130252 1130500 - hypothetical protein gene gene4044 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04045 VSVS12_04046 VSVS12_04046 VSVS12_04046 1130727 1131050 - hypothetical protein gene gene4045 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04046 VSVS12_04047 VSVS12_04047 VSVS12_04047 1131225 1131926 - hypothetical protein gene gene4046 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04047 VSVS12_04048 VSVS12_04048 VSVS12_04048 1132726 1133220 - hypothetical protein gene gene4047 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04048 VSVS12_04049 VSVS12_04049 VSVS12_04049 1134075 1134293 + hypothetical protein gene gene4048 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04049 VSVS12_04050 VSVS12_04050 VSVS12_04050 1134293 1134514 + hypothetical protein gene gene4049 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04050 VSVS12_04051 VSVS12_04051 VSVS12_04051 1135216 1135581 - hypothetical protein gene gene4050 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04051 VSVS12_04052 VSVS12_04052 odc1 odc1 1135720 1136208 - Ornithine decarboxylase KEGG: amd:AMED_5536 ornithine decarboxylase gene gene4051 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04052 VSVS12_04053 VSVS12_04053 VSVS12_04053 1136469 1136747 + hypothetical protein gene gene4052 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04053 VSVS12_04054 VSVS12_04054 VSVS12_04054 1136912 1137199 - hypothetical protein gene gene4053 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04054 VSVS12_04055 VSVS12_04055 VSVS12_04055 1137199 1137477 - hypothetical protein gene gene4054 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04055 VSVS12_04056 VSVS12_04056 VSVS12_04056 1137877 1137987 + hypothetical protein gene gene4055 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04056 VSVS12_04057 VSVS12_04057 VSVS12_04057 1138256 1138675 - hypothetical protein gene gene4056 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04057 VSVS12_04058 VSVS12_04058 VSVS12_04058 1139381 1139770 - hypothetical protein gene gene4057 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04058 VSVS12_04059 VSVS12_04059 VSVS12_04059 1140021 1140188 + hypothetical protein gene gene4058 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04059 VSVS12_04060 VSVS12_04060 VSVS12_04060 1140465 1140656 - hypothetical protein gene gene4059 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04060 VSVS12_04061 VSVS12_04061 VSVS12_04061 1140833 1141249 - hypothetical protein gene gene4060 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04061 VSVS12_04062 VSVS12_04062 VSVS12_04062 1141425 1141772 - hypothetical protein gene gene4061 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04062 VSVS12_04063 VSVS12_04063 VSVS12_04063 1141972 1142481 - uncharacterized protein gene gene4062 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04063 VSVS12_04064 VSVS12_04064 VSVS12_04064 1143789 1144064 - hypothetical protein gene gene4063 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04064 VSVS12_04065 VSVS12_04065 VSVS12_04065 1144345 1144623 - hypothetical protein gene gene4064 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04065 VSVS12_04066 VSVS12_04066 VSVS12_04066 1144785 1145189 - hypothetical protein gene gene4065 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04066 VSVS12_04067 VSVS12_04067 VSVS12_04067 1145383 1145724 - hypothetical protein gene gene4066 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04067 VSVS12_04068 VSVS12_04068 VSVS12_04068 1145860 1146633 - hypothetical protein gene gene4067 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04068 VSVS12_04069 VSVS12_04069 VSVS12_04069 1146691 1146801 - hypothetical protein gene gene4068 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04069 VSVS12_04070 VSVS12_04070 VSVS12_04070 1146770 1147429 - hypothetical protein gene gene4069 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04070 VSVS12_04071 VSVS12_04071 VSVS12_04071 1147591 1147842 - hypothetical protein gene gene4070 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04071 VSVS12_04072 VSVS12_04072 VSVS12_04072 1148285 1148395 + hypothetical protein gene gene4071 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04072 VSVS12_04073 VSVS12_04073 VSVS12_04073 1148864 1148974 + hypothetical protein gene gene4072 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04073 VSVS12_04074 VSVS12_04074 VSVS12_04074 1149254 1149556 - hypothetical protein gene gene4073 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04074 VSVS12_04075 VSVS12_04075 VSVS12_04075 1150261 1150818 - hypothetical protein gene gene4074 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04075 VSVS12_04076 VSVS12_04076 VSVS12_04076 1151166 1151348 - hypothetical protein gene gene4075 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04076 VSVS12_04077 VSVS12_04077 VSVS12_04077 1152150 1152317 + hypothetical protein gene gene4076 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04077 VSVS12_04078 VSVS12_04078 VSVS12_04078 1152599 1152940 - hypothetical protein gene gene4077 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04078 VSVS12_04079 VSVS12_04079 VSVS12_04079 1153091 1153675 - UPF0167 protein Belongs to the UPF0167 family gene gene4078 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04079 VSVS12_04080 VSVS12_04080 VSVS12_04080 1153761 1154177 - hypothetical protein gene gene4079 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04080 VSVS12_04081 VSVS12_04081 VSVS12_04081 1154375 1154632 - hypothetical protein gene gene4080 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04081 VSVS12_04082 VSVS12_04082 VSVS12_04082 1154595 1154960 - hypothetical protein gene gene4081 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04082 VSVS12_04083 VSVS12_04083 VSVS12_04083 1155071 1156279 + hypothetical protein gene gene4082 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04083 VSVS12_04084 VSVS12_04084 VSVS12_04084 1158189 1158569 - Centromere protein Required for distribution of pericentromeric heterochromatin in interphase nuclei and for centromere formation and organization%2C chromosome alignment and cytokinesis%3B Belongs to the Gfa family gene gene4083 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04084 VSVS12_04085 VSVS12_04085 VSVS12_04085 1158821 1158988 + hypothetical protein gene gene4084 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04085 VSVS12_04086 VSVS12_04086 VSVS12_04086 1159278 1159778 - Ribosomal-protein-alanine N-acetyltransferase KEGG: slo:Shew_2943 ribosomal-protein-alanine N-acetyltransferase gene gene4085 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04086 VSVS12_04087 VSVS12_04087 VSVS12_04087 1159980 1160333 - hypothetical protein gene gene4086 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04087 VSVS12_04088 VSVS12_04088 VSVS12_04088 1160534 1161169 - Chloramphenicol O-acetyltransferase Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P)%2C which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate)%2C a reaction catalyzed by the N-terminal domain%3B In the N-terminal sectio%3B belongs to the N- acetylglucosamine-1-phosphate uridyltransferase family%3B In the C-terminal sectio%3B belongs to the transferase hexapeptide repeat family%3B KEGG: vsp:VS_II0508 chloramphenicol O-acetyltransferase type B gene gene4087 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04088 VSVS12_04089 VSVS12_04089 VSVS12_04089 1161285 1162493 + hypothetical protein gene gene4088 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04089 VSVS12_04090 VSVS12_04090 VSVS12_04090 1162633 1162725 + hypothetical protein gene gene4089 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04090 VSVS12_04091 VSVS12_04091 VSVS12_04091 1162769 1163620 - hypothetical protein gene gene4090 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04091 VSVS12_04092 VSVS12_04092 VSVS12_04092 1163771 1164979 - hypothetical protein gene gene4091 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04092 VSVS12_04093 VSVS12_04093 VSVS12_04093 1165102 1165854 - hypothetical protein gene gene4092 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04093 VSVS12_04094 VSVS12_04094 VSVS12_04094 1166009 1166356 - hypothetical protein gene gene4093 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04094 VSVS12_04095 VSVS12_04095 VSVS12_04095 1166650 1166922 + hypothetical protein gene gene4094 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04095 VSVS12_04096 VSVS12_04096 VSVS12_04096 1166919 1167416 + hypothetical protein gene gene4095 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04096 VSVS12_04097 VSVS12_04097 VSVS12_04097 1167574 1168782 - hypothetical protein gene gene4096 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04097 VSVS12_04098 VSVS12_04098 VSVS12_04098 1169331 1170317 - Sucrose operon repressor Repressor for the scr operon. Binds D-fructose as an inducer. Contains 1 HTH lacI-type DNA-binding domain gene gene4097 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04098 VSVS12_04099 VSVS12_04099 VSVS12_04099 1170552 1171991 + Protein-N(pi)-phosphohistidine--sugar phosphotransferase The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS)%2C a major carbohydrate active -transport system%2C catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in sucrose transport. Contains 1 PTS EIIB type-1 domain%3B Contains 1 PTS EIIC type-1 domain%3B KEGG: gan:UMN179_01099 PTS system%2C sucrose-specific IIB component gene gene4098 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04099 VSVS12_04100 VSVS12_04100 scrK scrK 1172148 1173143 + Fructokinase Belongs to the carbohydrate kinase PfkB family%3B KEGG: vag:N646_3834 fructokinase gene gene4099 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04100 VSVS12_04101 VSVS12_04101 sacA sacA 1173140 1174585 + Beta-fructofuranosidase Enables the bacterium to metabolize sucrose as a sole carbon source. Belongs to the glycosyl hydrolase 32 family%3B KEGG: vag:N646_3835 beta-fructofuranosidase gene gene4100 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04101 VSVS12_04102 VSVS12_04102 VSVS12_04102 1175543 1175722 + hypothetical protein gene gene4101 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04102 VSVS12_04103 VSVS12_04103 VSVS12_04103 1175962 1177080 + hypothetical protein gene gene4102 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04103 VSVS12_04104 VSVS12_04104 VSVS12_04104 1177566 1177889 - hypothetical protein gene gene4103 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04104 VSVS12_04105 VSVS12_04105 VSVS12_04105 1177975 1178124 - hypothetical protein gene gene4104 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04105 VSVS12_04106 VSVS12_04106 VSVS12_04106 1178158 1178649 - hypothetical protein gene gene4105 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04106 VSVS12_04107 VSVS12_04107 VSVS12_04107 1178676 1178855 - hypothetical protein gene gene4106 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04107 VSVS12_04108 VSVS12_04108 VSVS12_04108 1179191 1180399 - hypothetical protein gene gene4107 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04108 VSVS12_04109 VSVS12_04109 VSVS12_04109 1180503 1181519 - Melibiose carrier protein Responsible for melibiose and other galactoside transport. It is capable of using hydrogen%2C sodium%2C and lithium cations as coupling cations for cotransport%2C depending on the particular sugar transported (symport system). Belongs to the sodium:galactoside symporter (TC 2. A. 2) family gene gene4108 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04109 VSVS12_04110 VSVS12_04110 melA melA 1181629 1182981 - Alpha-galactosidase Belongs to the glycosyl hydrolase 4 family%3B KEGG: esc:Entcl_3271 alpha-galactosidase gene gene4109 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04110 VSVS12_04111 VSVS12_04111 VSVS12_04111 1183269 1184195 + Melibiose operon regulatory protein Transcription activator for the expression of the melAB operon. MelR binds at two sites located upstream of the melAB transcription site (By similarity)%3B Contains 1 HTH araC/xylS-type DNA-binding domain gene gene4110 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04111 VSVS12_04112 VSVS12_04112 VSVS12_04112 1184595 1185089 - Transposase for insertion sequence element IS1111A Required for the transposition of the insertion element%3B Belongs to the transposase IS1111A/IS1328/IS1533 family gene gene4111 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04112 VSVS12_04113 VSVS12_04113 VSVS12_04113 1185435 1186355 + putative transposase gene gene4112 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04113 VSVS12_04114 VSVS12_04114 VSVS12_04114 1186467 1187810 + Transposase Required for transposition of transposon Tn3926. Belongs to the transposase 7 family gene gene4113 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04114 VSVS12_04115 VSVS12_04115 VSVS12_04115 1187928 1188173 - Transposase for insertion sequence element IS1111A Required for the transposition of the insertion element%3B Belongs to the transposase IS1111A/IS1328/IS1533 family gene gene4114 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04115 VSVS12_04116 VSVS12_04116 VSVS12_04116 1188999 1190468 - Fructan beta-fructosidase Belongs to the glycosyl hydrolase 32 family%3B KEGG: pri:PRIO_1690 fructan beta-fructosidase gene gene4115 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04116 VSVS12_04117 VSVS12_04117 VSVS12_04117 1190652 1192307 - putative ABC transporter ATP-binding protein Belongs to the ABC transporter superfamily%3B Contains 2 ABC transporter domains gene gene4116 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04117 VSVS12_04118 VSVS12_04118 VSVS12_04118 1192330 1193409 - Dipeptide transport system permease protein DppC Part of the binding-protein-dependent transport system for dipeptide%3B probably responsible for the translocation of the substrate across the membrane%3B Belongs to the binding-protein-dependent transport system permease family. OppBC subfamily%3B Contains 1 ABC transmembrane type-1 domain gene gene4117 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04118 VSVS12_04119 VSVS12_04119 VSVS12_04119 1193419 1194417 - Nickel transport system permease protein Involved in a nickel transport system%2C probably translocates nickel through the bacterial inner membrane. Belongs to the binding-protein-dependent transport system permease family. OppBC subfamily%3B Contains 1 ABC transmembrane type-1 domain gene gene4118 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04119 VSVS12_04120 VSVS12_04120 VSVS12_04120 1194467 1196527 - Periplasmic alpha-galactoside-binding protein Probably involved in an alpha-galactosides intake transport system. Belongs to the bacterial solute-binding protein 5 family gene gene4119 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04120 VSVS12_04121 VSVS12_04121 VSVS12_04121 1197231 1197587 - hypothetical protein gene gene4120 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04121 VSVS12_04122 VSVS12_04122 VSVS12_04122 1197566 1197781 - hypothetical protein gene gene4121 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04122 VSVS12_04123 VSVS12_04123 VSVS12_04123 1198136 1198330 + hypothetical protein gene gene4122 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04123 VSVS12_04124 VSVS12_04124 VSVS12_04124 1198442 1199326 - hypothetical protein gene gene4123 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04124 VSVS12_04125 VSVS12_04125 VSVS12_04125 1199323 1200531 - hypothetical protein gene gene4124 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04125 VSVS12_04126 VSVS12_04126 VSVS12_04126 1200733 1202133 - UDP-glucose:undecaprenyl-phosphate glucose-1-phosphate transferase Is the initiating enzyme for colanic acid (CA) synthesis. Catalyzes the transfer of the glucose-1-phosphate moiety from UDP-Glc onto the carrier lipid undecaprenyl phosphate (C55-P)%2C forming a phosphoanhydride bond yielding to glucosyl- pyrophosphoryl-undecaprenol (Glc-PP-C55). Also possesses a weak galactose-1-P transferase activity%3B Belongs to the bacterial sugar transferase family gene gene4125 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04126 VSVS12_04127 VSVS12_04127 VSVS12_04127 1202643 1203392 - Phosphate-transporting ATPase Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system%3B Belongs to the ABC transporter superfamily. Phosphate importer (TC 3. A. 1. 7) family%3B Contains 1 ABC transporter domain%3B KEGG: vvu:VV2_1559 phosphate transport system ATP-binding protein gene gene4126 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04127 VSVS12_04128 VSVS12_04128 VSVS12_04128 1203422 1204291 - Phosphate transport system permease protein PstA Part of the binding-protein-dependent transport system for phosphat%3B probably responsible for the translocation of the substrate across the membrane%3B Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily%3B Contains 1 ABC transmembrane type-1 domain gene gene4127 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04128 VSVS12_04129 VSVS12_04129 VSVS12_04129 1204301 1205203 - Phosphate transport system permease protein PstC Part of the binding-protein-dependent transport system for phosphat%3B probably responsible for the translocation of the substrate across the membrane%3B Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily%3B Contains 1 ABC transmembrane type-1 domain gene gene4128 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04129 VSVS12_04130 VSVS12_04130 VSVS12_04130 1205326 1206147 - Phosphate-binding protein PstS Part of the ABC transporter complex PstSACB involved in phosphate import%3B Belongs to the PstS family gene gene4129 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04130 VSVS12_04131 VSVS12_04131 VSVS12_04131 1206571 1207302 - Protein-N(pi)-phosphohistidine--sugar phosphotransferase The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS)%2C a major carbohydrate active -transport system%2C catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in fructose transport. Contains 2 PTS EIIB type-2 domains%3B Contains 1 PTS EIIC type-2 domain%3B KEGG: vch:VC1821 PTS system%2C fructose-specific IIB-like component%3B overlaps another CDS with the same product name gene gene4130 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04131 VSVS12_04132 VSVS12_04132 VSVS12_04132 1207245 1208495 - Protein-N(pi)-phosphohistidine--sugar phosphotransferase The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS)%2C a major carbohydrate active -transport system%2C catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in mannose transport. Contains 1 PTS EIIA type-2 domain%3B Contains 1 PTS EIIB type-2 domain%3B Contains 1 PTS EIIC type-2 domain%3B KEGG: lmt:LMRG_00048 PTS system%2C fructose-specific IIA component%3B overlaps another CDS with the same product name gene gene4131 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04132 VSVS12_04133 VSVS12_04133 VSVS12_04133 1208661 1208963 + Protein-N(pi)-phosphohistidine--sugar phosphotransferase The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS)%2C a major carbohydrate active -transport system%2C catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in fructose transport. Contains 2 PTS EIIB type-2 domains%3B Contains 1 PTS EIIC type-2 domain%3B KEGG: eco:b3950 PTS system%2C fructose-specific IIB-like component gene gene4132 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04133 VSVS12_04134 VSVS12_04134 VSVS12_04134 1208987 1209763 + Protein-N(pi)-phosphohistidine--sugar phosphotransferase KEGG: vch:VC1824 PTS system%2C nitrogen regulatory IIA component gene gene4133 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04134 VSVS12_04135 VSVS12_04135 VSVS12_04135 1209807 1210646 - putative HTH-type transcriptional regulator YpdC Contains 1 HTH araC/xylS-type DNA-binding domain gene gene4134 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04135 VSVS12_04136 VSVS12_04136 VSVS12_04136 1211147 1212349 + Mannose-6-phosphate isomerase Involved in the conversion of glucose to GDP-L-fucose%2C which can be converted to L-fucose%2C a capsular polysaccharide. Belongs to the mannose-6-phosphate isomerase type 1 family%3B KEGG: vcf:IR04_14310 mannose-6-phosphate isomerase gene gene4135 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04136 VSVS12_04137 VSVS12_04137 VSVS12_04137 1212565 1213005 + Protein-N(pi)-phosphohistidine--sugar phosphotransferase KEGG: kpn:KPN_01743 PTS system%2C fructose-specific IIA component gene gene4136 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04137 VSVS12_04138 VSVS12_04138 VSVS12_04138 1213018 1214415 + Protein-N(pi)-phosphohistidine--sugar phosphotransferase The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS)%2C a major carbohydrate active -transport system%2C catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane%3B Contains 1 PTS EIIC type-2 domain%3B KEGG: vpa:VPA0297 PTS system%2C fructose-specific IIB-like component gene gene4137 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04138 VSVS12_04139 VSVS12_04139 VSVS12_04139 1214641 1216035 + putative HTH-type transcriptional regulator YtdP Contains 1 HTH araC/xylS-type DNA-binding domain gene gene4138 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04139 VSVS12_04140 VSVS12_04140 VSVS12_04140 1216120 1217679 - hypothetical protein gene gene4139 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04140 VSVS12_04141 VSVS12_04141 VSVS12_04141 1218007 1218216 - hypothetical protein gene gene4140 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04141 VSVS12_04142 VSVS12_04142 VSVS12_04142 1218424 1219164 - UPF0721 transmembrane protein Belongs to the UPF0721 family gene gene4141 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04142 VSVS12_04143 VSVS12_04143 VSVS12_04143 1219269 1220102 - hypothetical protein gene gene4142 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04143 VSVS12_04144 VSVS12_04144 VSVS12_04144 1220328 1220690 + hypothetical protein gene gene4143 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04144 VSVS12_04145 VSVS12_04145 lhgO lhgO 1220775 1221986 - L-2-hydroxyglutarate oxidase LhgO Oxidizes L-2-hydroxyglutarate%2C probably to recover alpha-ketoglutarate mistakenly reduced by other enzymes or formed during growth on propionate%3B Belongs to the L2HGDH family%3B KEGG: eco:b2660 L-2-hydroxyglutarate oxidase%3B With oxygen as acceptor gene gene4144 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04145 VSVS12_04146 VSVS12_04146 VSVS12_04146 1222153 1222353 - hypothetical protein gene gene4145 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04146 VSVS12_04147 VSVS12_04147 VSVS12_04147 1222848 1223804 + Protein MoxR May be involved in the regulation of formation of active methanol dehydrogenase. Belongs to the MoxR family%3B KEGG: tao:THIAE_02665 MoxR-like ATPase%3B Acting on acid anhydrides%3B catalyzing transmembrane movement of substances gene gene4146 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04147 VSVS12_04148 VSVS12_04148 VSVS12_04148 1223812 1224729 + uncharacterized protein To M. avium MAV169%3B KEGG: mtuh:I917_10510 MoxR-like ATPase%3B Acting on acid anhydrides%3B catalyzing transmembrane movement of substances gene gene4147 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04148 VSVS12_04149 VSVS12_04149 VSVS12_04149 1224734 1225195 + hypothetical protein gene gene4148 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04149 VSVS12_04150 VSVS12_04150 VSVS12_04150 1225196 1226164 + uncharacterized protein Contains 1 VWFA domain gene gene4149 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04150 VSVS12_04151 VSVS12_04151 VSVS12_04151 1226157 1228094 + Mediator of RNA polymerase II transcription subunit Component of the Mediator complex%2C a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for cholesterol-dependent gene regulation (By similarity). Positively regulates the Nodal signaling pathway%3B Belongs to the Mediator complex subunit 15 family gene gene4150 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04151 VSVS12_04152 VSVS12_04152 VSVS12_04152 1228088 1229761 + hypothetical protein gene gene4151 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04152 VSVS12_04153 VSVS12_04153 VSVS12_04153 1229891 1230058 + hypothetical protein gene gene4152 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04153 VSVS12_04154 VSVS12_04154 VSVS12_04154 1230086 1232209 - Diguanylate cyclase Contains 1 EAL domain%3B Contains 1 GGDEF domain%3B Contains 1 MHYT domain%3B KEGG: dal:Dalk_2974 two-component system%2C cell cycle response regulator gene gene4153 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04154 VSVS12_04155 VSVS12_04155 VSVS12_04155 1232566 1233111 + hypothetical protein gene gene4154 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04155 VSVS12_04156 VSVS12_04156 VSVS12_04156 1233230 1233628 - hypothetical protein gene gene4155 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04156 VSVS12_04157 VSVS12_04157 VSVS12_04157 1233641 1234627 - putative oxidoreductase YgjR Belongs to the Gfo/Idh/MocA family%3B KEGG: vfi:VF_A0726 null%3B With NAD(+) or NADP(+) as acceptor gene gene4156 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04157 VSVS12_04158 VSVS12_04158 VSVS12_04158 1234675 1235241 - putative membrane protein Belongs to the rht family gene gene4157 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04158 VSVS12_04159 VSVS12_04159 VSVS12_04159 1235382 1236302 - Nodulation protein D NodD regulates the expression of the nodABCFE genes which encode other nodulation proteins. NodD is also a negative regulator of its own expression. Binds flavonoids as inducers. Contains 1 HTH lysR-type DNA-binding domain gene gene4158 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04159 VSVS12_04160 VSVS12_04160 VSVS12_04160 1236295 1236744 - HTH-type transcriptional regulator Ptr1 Participates in positive as well as negative regulation of transcription. Binds to its own promoter. Contains 1 HTH asnC-type DNA-binding domain gene gene4159 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04160 VSVS12_04161 VSVS12_04161 VSVS12_04161 1236996 1238261 + Inner membrane protein YjeH gene gene4160 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04161 VSVS12_04162 VSVS12_04162 VSVS12_04162 1238265 1239320 - hypothetical protein gene gene4161 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04162 VSVS12_04163 VSVS12_04163 VSVS12_04163 1239384 1239713 + hypothetical protein gene gene4162 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04163 VSVS12_04164 VSVS12_04164 VSVS12_04164 1239707 1240930 + hypothetical protein gene gene4163 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04164 VSVS12_04165 VSVS12_04165 VSVS12_04165 1241249 1241653 - 8-oxo-dGTP diphosphatase KEGG: vni:VIBNI_B2151 8-oxo-dGTP diphosphatase gene gene4164 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04165 VSVS12_04166 VSVS12_04166 gabD gabD 1241926 1243395 - Succinate-semialdehyde dehydrogenase (NAD(P)(+)) Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate%3B Belongs to the aldehyde dehydrogenase family. AstD subfamily%3B KEGG: vvy:VV1589 succinate-semialdehyde dehydrogenase / glutarate-semialdehyde dehydrogenase gene gene4165 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04166 VSVS12_04167 VSVS12_04167 VSVS12_04167 1243737 1244648 + Methyl viologen resistance protein YddG Probable efflux pump. Required for resistance to methyl viologen. May function with OmpD porin%3B Belongs to the drug/metabolite transporter (DMT) superfamily. Aromatic amino acid/paraquat exporter (ArAA/P-E) (TC 2. A. 7. 17) family%3B Contains 2 EamA domains gene gene4166 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04167 VSVS12_04168 VSVS12_04168 VSVS12_04168 1244972 1250083 + Non-specific serine/threonine protein kinase Regulates the activity of endogenous beta-lactamase or related enzymes%2C by blocking their secretion by phosphorylation%2C in response to an external signal yet to be identified. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family%3B Contains 1 guanylate cyclase domain%3B Contains 1 protein kinase domain%3B KEGG: chy:CHY_1478 serine/threonine protein kinase%2C bacterial gene gene4167 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04168 VSVS12_04169 VSVS12_04169 VSVS12_04169 1250107 1252314 + Aldehyde dehydrogenase (NAD(+)) Catalyzes the conversion of methylglyoxal (MG) to D- lactate in a single glutathione (GSH)-independent step. May play a role in detoxifying endogenously produced glyoxals. Involved in protection against reactive oxygen species (ROS)%3B Belongs to the peptidase C56 family. HSP31-like subfamily%3B KEGG: sld:T261_0279 aldehyde dehydrogenase (NAD+) gene gene4168 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04169 VSVS12_04170 VSVS12_04170 VSVS12_04170 1252316 1252768 + hypothetical protein gene gene4169 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04170 VSVS12_04171 VSVS12_04171 VSVS12_04171 1252834 1254990 - Rhizobactin receptor Receptor for the siderophore rhizobactin. Belongs to the TonB-dependent receptor family gene gene4170 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04171 VSVS12_04172 VSVS12_04172 VSVS12_04172 1255432 1256388 - hypothetical protein gene gene4171 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04172 VSVS12_04173 VSVS12_04173 VSVS12_04173 1256606 1258603 - Hemin transport system permease protein HmuU Part of the binding-protein-dependent transport system for hemi%3B probably responsible for the translocation of the substrate across the membrane. Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily gene gene4172 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04173 VSVS12_04174 VSVS12_04174 VSVS12_04174 1258606 1259562 - Iron(3+)-hydroxamate-binding protein Part of the ABC transporter complex FhuCDB involved in iron(3+)-hydroxamate import. Binds the iron(3+)-hydroxamate complex and transfers it to the membrane-bound permease. Required for the transport of all iron(3+)-hydroxamate siderophores such as ferrichrome%2C gallichrome%2C desferrioxamine%2C coprogen%2C aerobactin%2C shizokinen%2C rhodotorulic acid and the antibiotic albomycin. Belongs to the bacterial solute-binding protein 8 family%3B Contains 1 Fe/B12 periplasmic-binding domain gene gene4173 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04174 VSVS12_04175 VSVS12_04175 VSVS12_04175 1259580 1260347 - Iron-chelate-transporting ATPase Involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. Also acts as a molecular scaffold for the final stage of MHC class I folding%2C namely the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin (By similarity)%3B Belongs to the ABC transporter superfamily. ABCB family. MHC peptide exporter (TC 3. A. 1. 209) subfamily%3B Contains 1 ABC transmembrane type-1 domain%3B Contains 1 ABC transporter domain%3B KEGG: tmo:TMO_b0220 iron complex transport system ATP-binding protein gene gene4174 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04175 VSVS12_04176 VSVS12_04176 VSVS12_04176 1260500 1261687 + hypothetical protein gene gene4175 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04176 VSVS12_04177 VSVS12_04177 VSVS12_04177 1261699 1262433 - hypothetical protein gene gene4176 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04177 VSVS12_04178 VSVS12_04178 VSVS12_04178 1262506 1263366 - putative HTH-type transcriptional regulator YafC Contains 1 HTH lysR-type DNA-binding domain gene gene4177 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04178 VSVS12_04179 VSVS12_04179 VSVS12_04179 1263466 1264530 + p-hydroxybenzoic acid efflux pump subunit AaeA Forms an efflux pump with AaeB%3B Belongs to the membrane fusion protein (MFP) (TC 8. A. 1) family gene gene4178 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04179 VSVS12_04180 VSVS12_04180 VSVS12_04180 1264549 1265556 + hypothetical protein gene gene4179 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04180 VSVS12_04181 VSVS12_04181 VSVS12_04181 1265647 1266426 - hypothetical protein gene gene4180 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04181 VSVS12_04182 VSVS12_04182 VSVS12_04182 1266736 1267749 - HTH-type transcriptional regulator GalS Repressor of the mgl operon. Binds galactose and D- fucose as inducers. GalS binds to an operator DNA sequence within its own coding sequence (corresponding to residues 15 to 20). Contains 1 HTH lacI-type DNA-binding domain gene gene4181 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04182 VSVS12_04183 VSVS12_04183 VSVS12_04183 1267948 1268397 + Beta-fructofuranosidase Belongs to the glycosyl hydrolase 32 family%3B KEGG: awd:AWOD_II_1089 beta-fructofuranosidase gene gene4182 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04183 VSVS12_04184 VSVS12_04184 VSVS12_04184 1268366 1269574 - hypothetical protein gene gene4183 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04184 VSVS12_04185 VSVS12_04185 VSVS12_04185 1269634 1270560 - hypothetical protein gene gene4184 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04185 VSVS12_04186 VSVS12_04186 VSVS12_04186 1271231 1271635 + hypothetical protein gene gene4185 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04186 VSVS12_04187 VSVS12_04187 VSVS12_04187 1271641 1272024 + hypothetical protein gene gene4186 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04187 VSVS12_04188 VSVS12_04188 VSVS12_04188 1272364 1272861 + hypothetical protein gene gene4187 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04188 VSVS12_04189 VSVS12_04189 VSVS12_04189 1272819 1274027 - hypothetical protein gene gene4188 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04189 VSVS12_04190 VSVS12_04190 VSVS12_04190 1274278 1275072 + hypothetical protein gene gene4189 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04190 VSVS12_04191 VSVS12_04191 VSVS12_04191 1275363 1275761 - hypothetical protein gene gene4190 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04191 VSVS12_04192 VSVS12_04192 VSVS12_04192 1275868 1277076 + hypothetical protein gene gene4191 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04192 VSVS12_04193 VSVS12_04193 VSVS12_04193 1277034 1277759 - hypothetical protein gene gene4192 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04193 VSVS12_04194 VSVS12_04194 VSVS12_04194 1277901 1279010 - hypothetical protein gene gene4193 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04194 VSVS12_04195 VSVS12_04195 VSVS12_04195 1279393 1279518 - hypothetical protein gene gene4194 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04195 VSVS12_04196 VSVS12_04196 VSVS12_04196 1279550 1279960 - hypothetical protein gene gene4195 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04196 VSVS12_04197 VSVS12_04197 VSVS12_04197 1280036 1281244 - hypothetical protein gene gene4196 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04197 VSVS12_04198 VSVS12_04198 VSVS12_04198 1281845 1282822 + Chromosome partition protein Smc Required for chromosome condensation and partitioning%3B Belongs to the SMC family gene gene4197 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04198 VSVS12_04199 VSVS12_04199 VSVS12_04199 1283371 1284600 + Prophage CP4-57 integrase Integrase is necessary for integration of the phage into the host genome by site-specific recombination. In conjunction with excisionase%2C integrase is also necessary for excision of the prophage from the host genome. Belongs to the 'phage' integrase family gene gene4198 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04199 VSVS12_04200 VSVS12_04200 VSVS12_04200 1285272 1285676 + hypothetical protein gene gene4199 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04200 VSVS12_04201 VSVS12_04201 VSVS12_04201 1285875 1286642 - hypothetical protein gene gene4200 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04201 VSVS12_04202 VSVS12_04202 VSVS12_04202 1286642 1286872 - uncharacterized protein To E. coli prophage CP4-57 regulatory protein alpA gene gene4201 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04202 VSVS12_04203 VSVS12_04203 VSVS12_04203 1287237 1287551 + hypothetical protein gene gene4202 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04203 VSVS12_04204 VSVS12_04204 VSVS12_04204 1288090 1289502 + hypothetical protein gene gene4203 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04204 VSVS12_04205 VSVS12_04205 VSVS12_04205 1289606 1290820 + hypothetical protein gene gene4204 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04205 VSVS12_04206 VSVS12_04206 VSVS12_04206 1290948 1291649 + hypothetical protein gene gene4205 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04206 VSVS12_04207 VSVS12_04207 VSVS12_04207 1292073 1292783 - Transcriptional activator PerA Could help in the transcriptional activator of eaeA expression in enteropathogenic E. coli. However%2C it seems that it is PerC which acts as an activator. Contains 1 HTH araC/xylS-type DNA-binding domain gene gene4206 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04207 VSVS12_04208 VSVS12_04208 VSVS12_04208 1292749 1293504 - hypothetical protein gene gene4207 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04208 VSVS12_04209 VSVS12_04209 VSVS12_04209 1293818 1294201 - hypothetical protein gene gene4208 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04209 VSVS12_04210 VSVS12_04210 VSVS12_04210 1294194 1295489 - hypothetical protein gene gene4209 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04210 VSVS12_04211 VSVS12_04211 VSVS12_04211 1295579 1295669 - tRNA-Ser tRNA gene4210 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04211 VSVS12_04212 VSVS12_04212 VSVS12_04212 1296004 1296681 + Nodulation protein Involved in the production of the root hair deformation (HAD) factor specifically on medicago. Contains 1 MaoC-like domain%3B To the R. leguminosarum biovar viciae counterpart gene gene4211 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04212 VSVS12_04213 VSVS12_04213 VSVS12_04213 1296739 1297554 - Phosphate-binding protein PstS Part of the ABC transporter complex PstSACB involved in phosphate import%3B Belongs to the PstS family gene gene4212 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04213 VSVS12_04214 VSVS12_04214 VSVS12_04214 1297788 1298135 + hypothetical protein gene gene4213 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04214 VSVS12_04215 VSVS12_04215 VSVS12_04215 1298185 1298820 - hypothetical protein gene gene4214 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04215 VSVS12_04216 VSVS12_04216 VSVS12_04216 1299001 1315077 - Serralysin Peptidase able to cleave azocasein and the milk substrates beta-casein and Na-caseinate. Can withstand UHT processing of milk%2C and is able to spoil UHT milk over the storage period%3B Belongs to the peptidase M10B family%3B Contains 3 hemolysin-type calcium-binding repeats%3B KEGG: hde:HDEF_0400 serralysin gene gene4215 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04216 VSVS12_04217 VSVS12_04217 VSVS12_04217 1315444 1317036 + Phytochrome-like protein cph2 Photoreceptor which exists in two forms that are reversibly interconvertible by light: the R form that absorbs maximally in the red region of the spectrum and the FR form that absorbs maximally in the far-red region. Belongs to the phytochrome family%3B Contains 1 EAL domain%3B Contains 2 GAF domains%3B Contains 2 GGDEF domains gene gene4216 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04217 VSVS12_04218 VSVS12_04218 VSVS12_04218 1317105 1318013 - putative oxidoreductase YcsN Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily%3B KEGG: vfi:VF_A0411 null%3B With NAD(+) or NADP(+) as acceptor gene gene4217 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04218 VSVS12_04219 VSVS12_04219 VSVS12_04219 1318312 1319364 - 3-deoxy-7-phosphoheptulonate synthase Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)%3B Belongs to the class-I DAHP synthase family%3B KEGG: eca:ECA1851 3-deoxy-7-phosphoheptulonate synthase gene gene4218 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04219 VSVS12_04220 VSVS12_04220 VSVS12_04220 1319758 1320114 - hypothetical protein gene gene4219 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04220 VSVS12_04221 VSVS12_04221 cyoE cyoE 1320272 1321168 - Protoheme IX farnesyltransferase Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group%3B Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily%3B KEGG: vtu:IX91_22310 protoheme IX farnesyltransferase%3B Transferring alkyl or aryl groups%2C other than methyl groups gene gene4220 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04221 VSVS12_04222 VSVS12_04222 VSVS12_04222 1321161 1322255 - Heme A synthase Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group%3B Belongs to the COX15/CtaA family. Type 2 subfamily gene gene4221 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04222 VSVS12_04223 VSVS12_04223 VSVS12_04223 1322265 1322813 - hypothetical protein gene gene4222 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04223 VSVS12_04224 VSVS12_04224 VSVS12_04224 1322838 1323533 - hypothetical protein gene gene4223 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04224 VSVS12_04225 VSVS12_04225 VSVS12_04225 1323595 1323831 + hypothetical protein gene gene4224 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04225 VSVS12_04226 VSVS12_04226 coxC coxC 1323914 1324798 - Cytochrome-c oxidase Subunits I%2C II and III form the functional core of the enzyme complex. Belongs to the cytochrome c oxidase subunit 3 family%3B KEGG: vha:VIBHAR_06269 cytochrome c oxidase subunit III gene gene4225 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04226 VSVS12_04227 VSVS12_04227 VSVS12_04227 1324864 1325505 - Cytochrome c oxidase assembly protein COX11%2C mitochondrial Exerts its effect at some terminal stage of cytochrome c oxidase synthesis%2C probably by being involved in the insertion of the copper B into subunit I%3B Belongs to the COX11/CtaG family gene gene4226 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04227 VSVS12_04228 VSVS12_04228 coxA coxA 1325516 1327156 - Cytochrome-c oxidase Mitochondrial DNA endonuclease involved in intron homing%3B In the C-terminal sectio%3B belongs to the LAGLIDADG endonuclease family%3B In the N-terminal sectio%3B belongs to the heme-copper respiratory oxidase family%3B KEGG: pin:Ping_2716 cytochrome c oxidase subunit I%3B overlaps another CDS with the same product name gene gene4227 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04228 VSVS12_04229 VSVS12_04229 coxB coxB 1327153 1328223 - Cytochrome-c oxidase Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B (By similarity)%3B In the N-terminal sectio%3B belongs to the heme-copper respiratory oxidase family%3B In the C-terminal sectio%3B belongs to the cytochrome c oxidase subunit 2 family%3B KEGG: vvu:VV2_0568 cytochrome c oxidase subunit II%3B overlaps another CDS with the same product name gene gene4228 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04229 VSVS12_04230 VSVS12_04230 VSVS12_04230 1328240 1328386 - hypothetical protein gene gene4229 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04230 VSVS12_04231 VSVS12_04231 VSVS12_04231 1328654 1330357 + Phosphomannomutase Glucose 1%2C6-bisphosphate synthase using 1%2C3- bisphosphoglycerate as a phosphate donor and a series of 1- phosphate sugars as acceptors%2C including glucose 1-phosphate%2C mannose 1-phosphate%2C ribose 1-phosphate and deoxyribose 1- phosphate. 5 or 6-phosphosugars are bad substrates%2C with the exception of glucose 6-phosphate. Also synthesizes ribose 1%2C5- bisphosphate. Has only low phosphopentomutase and phosphoglucomutase activities%3B Belongs to the phosphohexose mutase family%3B KEGG: vfu:vfu_B01099 phosphomannomutase gene gene4230 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04231 VSVS12_04232 VSVS12_04232 VSVS12_04232 1330448 1330867 - DNA-directed DNA polymerase KEGG: bww:bwei_2369 DNA polymerase III subunit beta gene gene4231 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04232 VSVS12_04233 VSVS12_04233 VSVS12_04233 1331048 1331683 - Leucine efflux protein Exporter of leucine%3B Belongs to the rht family gene gene4232 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04233 VSVS12_04234 VSVS12_04234 VSVS12_04234 1331960 1332787 + putative HTH-type transcriptional regulator YbfI Contains 1 HTH araC/xylS-type DNA-binding domain gene gene4233 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04234 VSVS12_04235 VSVS12_04235 VSVS12_04235 1332862 1333659 + hypothetical protein gene gene4234 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04235 VSVS12_04236 VSVS12_04236 VSVS12_04236 1333656 1333970 + hypothetical protein gene gene4235 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04236 VSVS12_04237 VSVS12_04237 VSVS12_04237 1334081 1334695 - 5-carboxymethyl-2-hydroxymuconate Delta-isomerase Belongs to the FAH family%3B KEGG: gur:Gura_3666 5-carboxymethyl-2-hydroxymuconate isomerase gene gene4236 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04237 VSVS12_04238 VSVS12_04238 VSVS12_04238 1334848 1335894 - hypothetical protein gene gene4237 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04238 VSVS12_04239 VSVS12_04239 VSVS12_04239 1336384 1337043 - hypothetical protein gene gene4238 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04239 VSVS12_04240 VSVS12_04240 VSVS12_04240 1337155 1338597 + putative HTH-type transcriptional regulator YisV In the C-terminal sectio%3B belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family%3B Contains 1 HTH gntR-type DNA-binding domain gene gene4239 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04240 VSVS12_04241 VSVS12_04241 VSVS12_04241 1338856 1339068 + Cold shock-like protein CspA Contains 1 CSD (cold-shock) domain gene gene4240 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04241 VSVS12_04242 VSVS12_04242 VSVS12_04242 1339133 1339768 - hypothetical protein gene gene4241 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04242 VSVS12_04243 VSVS12_04243 VSVS12_04243 1339796 1340665 - uncharacterized protein Probable lipid hydrolase%3B Contains 1 patatin domain gene gene4242 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04243 VSVS12_04244 VSVS12_04244 VSVS12_04244 1340842 1341480 - Pyroglutamyl-peptidase I Removes 5-oxoproline from various penultimate amino acid residues except L-proline%3B Belongs to the peptidase C15 family%3B KEGG: ype:YPO2703 pyroglutamyl-peptidase gene gene4243 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04244 VSVS12_04245 VSVS12_04245 VSVS12_04245 1341489 1342394 - hypothetical protein gene gene4244 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04245 VSVS12_04246 VSVS12_04246 VSVS12_04246 1342397 1343119 - Pyroglutamyl-peptidase I KEGG: gea:GARCT_01780 pyroglutamyl-peptidase gene gene4245 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04246 VSVS12_04247 VSVS12_04247 VSVS12_04247 1343715 1344644 - Putative methyl-accepting chemotaxis protein Belongs to the phytochrome family%3B Contains 2 GAF domains%3B Contains 1 HAMP domain%3B Contains 1 methyl-accepting transducer domain gene gene4246 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04247 VSVS12_04248 VSVS12_04248 VSVS12_04248 1344751 1345959 + hypothetical protein gene gene4247 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04248 VSVS12_04249 VSVS12_04249 VSVS12_04249 1345917 1346150 - hypothetical protein gene gene4248 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04249 VSVS12_04250 VSVS12_04250 VSVS12_04250 1346494 1347336 - hypothetical protein gene gene4249 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04250 VSVS12_04251 VSVS12_04251 VSVS12_04251 1347776 1348738 + hypothetical protein gene gene4250 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04251 VSVS12_04252 VSVS12_04252 VSVS12_04252 1349037 1349267 - uncharacterized protein gene gene4251 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04252 VSVS12_04253 VSVS12_04253 VSVS12_04253 1349391 1350062 - hypothetical protein gene gene4252 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04253 VSVS12_04254 VSVS12_04254 VSVS12_04254 1350160 1350510 - hypothetical protein gene gene4253 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04254 VSVS12_04255 VSVS12_04255 VSVS12_04255 1350745 1351911 - Serine-type D-Ala-D-Ala carboxypeptidase Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors. Belongs to the peptidase S11 family%3B KEGG: amt:Amet_2528 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 5/6) gene gene4254 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04255 VSVS12_04256 VSVS12_04256 VSVS12_04256 1352087 1352443 - hypothetical protein gene gene4255 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04256 VSVS12_04257 VSVS12_04257 VSVS12_04257 1353164 1353373 + Cold shock-like protein CspA Contains 1 CSD (cold-shock) domain gene gene4256 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04257 VSVS12_04258 VSVS12_04258 VSVS12_04258 1353439 1353975 + uncharacterized protein gene gene4257 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04258 VSVS12_04259 VSVS12_04259 VSVS12_04259 1353968 1354507 + hypothetical protein gene gene4258 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04259 VSVS12_04260 VSVS12_04260 yhb1 yhb1 1354556 1355716 - Nitric oxide dioxygenase Is involved in NO detoxification in an aerobic process%2C termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate%2C which protects the bacterium from various noxious nitrogen compounds. Therefore%2C plays a central role in the inducible response to nitrosative stress%3B Belongs to the globin family. Two-domain flavohemoproteins subfamily%3B In the C-terminal sectio%3B belongs to the flavoprotein pyridine nucleotide cytochrome reductase family%3B Contains 1 FAD-binding FR-type domain%3B KEGG: eca:ECA3251 nitric oxide dioxygenase gene gene4259 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04260 VSVS12_04261 VSVS12_04261 VSVS12_04261 1355913 1357496 + Regulatory protein LuxO Involved in the regulation of different processes depending on the cell density. Acts together with sigma-54 to repress%2C perhaps indirectly%2C some genes. Contains 1 sigma-54 factor interaction domain gene gene4260 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04261 VSVS12_04262 VSVS12_04262 VSVS12_04262 1357559 1357918 + hypothetical protein gene gene4261 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04262 VSVS12_04263 VSVS12_04263 VSVS12_04263 1357970 1358584 + hypothetical protein gene gene4262 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04263 VSVS12_04264 VSVS12_04264 VSVS12_04264 1358674 1359294 + Glutathione-regulated potassium-efflux system ancillary protein KefG Regulatory subunit of a potassium efflux system that confers protection against electrophiles. Required for full activity of KefB%3B Belongs to the NAD(P)H dehydrogenase (quinone) family. KefG subfamily gene gene4263 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04264 VSVS12_04265 VSVS12_04265 VSVS12_04265 1359291 1361213 + Glutathione-regulated potassium-efflux system protein KefC Pore-forming subunit of a potassium efflux system that confers protection against electrophiles. Catalyzes K(+)/H(+) antiport%3B Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2. A. 37) family. KefC subfamily%3B Contains 1 RCK N-terminal domain gene gene4264 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04265 VSVS12_04266 VSVS12_04266 VSVS12_04266 1361337 1362656 + putative transporter Belongs to the multi antimicrobial extrusion (MATE) (TC 2. A. 66. 1) family gene gene4265 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04266 VSVS12_04267 VSVS12_04267 VSVS12_04267 1362917 1363894 + hypothetical protein gene gene4266 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04267 VSVS12_04268 VSVS12_04268 VSVS12_04268 1363953 1364840 + Riboflavin transporter Transports riboflavin into the cell. Can also transport FMN and FAD. Required for normal nodule development during colonization of pea plant roots%3B Belongs to the drug/metabolite transporter (DMT) superfamily. 10 TMS drug/metabolite exporter (DME) (TC 2. A. 7. 3) family%3B Contains 2 EamA domains gene gene4267 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04268 VSVS12_04269 VSVS12_04269 VSVS12_04269 1364972 1365586 + hypothetical protein gene gene4268 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04269 VSVS12_04270 VSVS12_04270 VSVS12_04270 1365719 1366912 + Transposase for insertion sequence element IS1001 Involved in the transposition of the insertion sequence. Belongs to the transposase 12 family gene gene4269 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04270 VSVS12_04271 VSVS12_04271 VSVS12_04271 1366973 1367374 - hypothetical protein gene gene4270 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04271 VSVS12_04272 VSVS12_04272 VSVS12_04272 1367438 1368664 - Multidrug resistance protein Multidrug resistance pump that participates in a low energy shock adaptive response. Belongs to the major facilitator superfamily gene gene4271 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04272 VSVS12_04273 VSVS12_04273 VSVS12_04273 1368730 1369602 + HTH-type transcriptional regulator AbgR Could be the regulator of the abg operon. Contains 1 HTH lysR-type DNA-binding domain gene gene4272 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04273 VSVS12_04274 VSVS12_04274 VSVS12_04274 1369705 1370829 + Cyclic di-GMP phosphodiesterase Gmr Part of a 2 protein system that seems to be dedicated to transcription of csgD. This protein decreases csgD transcription and thus decreases expression of adhesive curli fimbriae genes csgEFG%2C csgBAC/ymaD and adrA (yaic). Activity of this protein is antagonized by the diguanylate cyclase YdaM. In vitro has c-di-GMP phosphodiesterase activity. Cyclic-di-GMP is a second messenger which controls cell surface-associated traits in bacteria%3B Contains 1 EAL domain%3B Contains 1 GGDEF domain%3B Contains 1 PAS (PER-ARNT-SIM) domain gene gene4273 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04274 VSVS12_04275 VSVS12_04275 VSVS12_04275 1370808 1371545 + Protein-glutamate O-methyltransferase Plays an essential role in the maintenance and the formation of the three-dimensional structure of the biofilms at the later stages of their development. Absence of mbaA promotes the accumulation of larger amount of biomass on the surfaces at later stage of development%2C results in the overproduction of an extracellular polymeric substance that accumulates in the matrix of biofilms. This yields biofilms lacking the typical structure consisting of pillars of cells separated by fluid filled channels%3B Contains 1 EAL domain%3B Contains 1 GGDEF domain%3B Contains 1 HAMP domain%3B KEGG: mca:MCA1246 two-component system%2C chemotaxis family%2C CheB/CheR fusion protein gene gene4274 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04275 VSVS12_04276 VSVS12_04276 VSVS12_04276 1371582 1372070 - hypothetical protein gene gene4275 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04276 VSVS12_04277 VSVS12_04277 nadD nadD 1372130 1372642 - Nicotinate-nucleotide adenylyltransferase KEGG: vvu:VV2_1600 nicotinate-nucleotide adenylyltransferase gene gene4276 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04277 VSVS12_04278 VSVS12_04278 nadE nadE 1372745 1373572 + NAD(+) synthase Belongs to the NAD synthetase family%3B KEGG: vvu:VV2_1599 NAD+ synthase gene gene4277 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04278 VSVS12_04279 VSVS12_04279 VSVS12_04279 1373671 1374342 - putative transcriptional regulatory protein YhcZ Member of the two-component regulatory system YhcY/YhcZ%3B Contains 1 HTH luxR-type DNA-binding domain%3B Contains 1 response regulatory domain gene gene4278 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04279 VSVS12_04280 VSVS12_04280 plaU plaU 1374482 1375528 - U-plasminogen activator Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin. Belongs to the peptidase S1 family%3B Contains 1 EGF-like domain%3B Contains 1 kringle domain%3B Contains 1 peptidase S1 domain%3B KEGG: mmu:18792 urokinase plasminogen activator gene gene4279 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04280 VSVS12_04281 VSVS12_04281 gcvT gcvT 1375703 1376821 - Aminomethyltransferase The glycine cleavage system catalyzes the degradation of glycine%3B Belongs to the GcvT family%3B KEGG: dat:HRM2_25000 aminomethyltransferase gene gene4280 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04281 VSVS12_04282 VSVS12_04282 VSVS12_04282 1377099 1377722 - hypothetical protein gene gene4281 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04282 VSVS12_04283 VSVS12_04283 VSVS12_04283 1378345 1378725 + Glycine cleavage system H protein The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein%3B Belongs to the GcvH family%3B Contains 1 lipoyl-binding domain gene gene4282 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04283 VSVS12_04284 VSVS12_04284 gldC gldC 1378850 1381717 + Glycine dehydrogenase (aminomethyl-transferring) The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofacto%3B CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein%3B Belongs to the GcvP family%3B KEGG: vpa:VPA0801 glycine dehydrogenase gene gene4283 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04284 VSVS12_04285 VSVS12_04285 VSVS12_04285 1382266 1382874 + putative HTH-type transcriptional regulator YhgD Contains 1 HTH tetR-type DNA-binding domain gene gene4284 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04285 VSVS12_04286 VSVS12_04286 VSVS12_04286 1383043 1383564 + uncharacterized protein gene gene4285 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04286 VSVS12_04287 VSVS12_04287 VSVS12_04287 1383589 1383732 + hypothetical protein gene gene4286 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04287 VSVS12_04288 VSVS12_04288 VSVS12_04288 1383794 1384633 + hypothetical protein gene gene4287 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04288 VSVS12_04289 VSVS12_04289 VSVS12_04289 1384706 1385323 - Cysteine/O-acetylserine efflux protein Exporter of O-acetylserine (OAS) and cysteine%3B Belongs to the rht family gene gene4288 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04289 VSVS12_04290 VSVS12_04290 VSVS12_04290 1385596 1386576 + Integrase/recombinase Putative integrase believed to be involved in the insertion of antibiotic resistance genes into plasmids and transposons. Belongs to the 'phage' integrase family gene gene4289 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04290 VSVS12_04291 VSVS12_04291 VSVS12_04291 1386703 1387056 - 50S ribosomal protein L20%2C chloroplastic Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit%3B Belongs to the ribosomal protein L20P family gene gene4290 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04291 VSVS12_04292 VSVS12_04292 VSVS12_04292 1387098 1387292 - 50S ribosomal protein L35 Belongs to the ribosomal protein L35P family gene gene4291 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04292 VSVS12_04293 VSVS12_04293 VSVS12_04293 1387412 1387801 - Translation initiation factor IF-3 IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits%2C thus enhancing the availability of 30S subunits on which protein synthesis initiation begins%3B Belongs to the IF-3 family gene gene4292 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04293 VSVS12_04294 VSVS12_04294 tarS tarS 1387967 1389895 - Threonine--tRNA ligase Belongs to the class-II aminoacyl-tRNA synthetase family%3B KEGG: eco:b1719 threonyl-tRNA synthetase gene gene4293 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04294 VSVS12_04295 VSVS12_04295 VSVS12_04295 1390312 1391940 - Methyl-accepting chemotaxis protein McpC Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment%2C transduce a signal from the outside to the inside of the cell%2C and facilitate sensory adaptation through the variation of the level of methylation. All amino acids serve as attractants in B. subtilis%2C they appear to cause an increase in the turnover methyl groups%2C leading to methylation of an unidentified acceptor%2C while repellents have been shown to cause a decrease in methyl group turnover. The methyl groups are added by a methyltransferase and removed by a methylesterase. McpC is required for taxis to cysteine%2C proline%2C threonine%2C glycine%2C serine%2C lysine%2C valine and arginine and for aspartate%2C glutamine%2C histidine and glutamate. Primarily mediates response to positive stimulus of PTS carbohydrates. Greatly influences the duration or magnitude of the response to negative PTS carbohydrate stimulus%3B Contains 1 cache domain%3B Contains 1 HAMP domain%3B Contains 1 methyl-accepting transducer domain gene gene4294 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04295 VSVS12_04296 VSVS12_04296 VSVS12_04296 1392194 1393189 - hypothetical protein gene gene4295 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04296 VSVS12_04297 VSVS12_04297 VSVS12_04297 1393376 1393816 - Transcriptional regulatory protein DoeX Acts as a transcriptional regulator%3B Contains 1 HTH asnC-type DNA-binding domain gene gene4296 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04297 VSVS12_04298 VSVS12_04298 VSVS12_04298 1393958 1394545 + Cysteine/O-acetylserine efflux protein Exporter of O-acetylserine (OAS) and cysteine%3B Belongs to the rht family gene gene4297 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04298 VSVS12_04299 VSVS12_04299 VSVS12_04299 1394738 1395520 + Vibriobactin utilization protein ViuB Involved in intracellular removal of iron from iron- vibriobactin complex. Vibriobactin is an iron-chelating compound involved in the transport of iron from the bacterial environment into the cell cytoplasm%3B Belongs to the SIP oxidoreductase family%3B Contains 1 FAD-binding FR-type domain gene gene4298 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04299 VSVS12_04300 VSVS12_04300 VSVS12_04300 1395674 1396546 - HTH-type transcriptional regulator PtxR Transcriptional activator of the toxA (exotoxin) and regA genes. Contains 1 HTH lysR-type DNA-binding domain gene gene4299 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04300 VSVS12_04301 VSVS12_04301 VSVS12_04301 1396730 1397878 + S-(hydroxymethyl)glutathione dehydrogenase Oxidizes long-chain aliphatic alcohols%2C long-chain hydroxylated fatty acids and S-hydroxymethylglutathione (hmGSH) in increasing order of preference. Shows little or no activity with short-chain aliphatic alcohols. Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily%3B KEGG: vpa:VPA0071 S-(hydroxymethyl)glutathione dehydrogenase / alcohol dehydrogenase gene gene4300 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04301 VSVS12_04302 VSVS12_04302 frmB frmB 1398068 1398907 + S-formylglutathione hydrolase Serine hydrolase involved in the detoxification of formaldehyde. Hydrolyzes S-formylglutathione to glutathione and formate (By similarity)%3B Belongs to the esterase D family%3B KEGG: vpa:VPA0070 S-formylglutathione hydrolase gene gene4301 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04302 VSVS12_04303 VSVS12_04303 VSVS12_04303 1399147 1399548 + hypothetical protein gene gene4302 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04303 VSVS12_04304 VSVS12_04304 VSVS12_04304 1399687 1401405 + tRNA pseudouridine(32) synthase Responsible for synthesis of pseudouridine from uracil- 65 in transfer RNAs%3B Belongs to the pseudouridine synthase RluA family%3B KEGG: vcy:IX92_18645 tRNA pseudouridine32 synthase / 23S rRNA pseudouridine746 synthase gene gene4303 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04304 VSVS12_04305 VSVS12_04305 VSVS12_04305 1401524 1402075 - Maltose O-acetyltransferase May assist cellular detoxification by acetylating non- metabolizable pyranosides%2C thereby preventing their reentry into the cell. Belongs to the transferase hexapeptide repeat family%3B KEGG: vsp:VS_II0099 maltose O-acetyltransferase gene gene4304 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04305 VSVS12_04306 VSVS12_04306 VSVS12_04306 1402139 1403233 - NADPH dehydrogenase Reduces a range of alternative electron acceptors. In the N-terminal sectio%3B belongs to the NADH:flavin oxidoreductase/NADH oxidase family%3B KEGG: ttm:Tthe_1998 NADPH2 dehydrogenase gene gene4305 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04306 VSVS12_04307 VSVS12_04307 VSVS12_04307 1403672 1403863 + hypothetical protein gene gene4306 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04307 VSVS12_04308 VSVS12_04308 VSVS12_04308 1404089 1404316 + UPF0267 protein Belongs to the UPF0267 family gene gene4307 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04308 VSVS12_04309 VSVS12_04309 VSVS12_04309 1404420 1405628 + hypothetical protein gene gene4308 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04309 VSVS12_04310 VSVS12_04310 VSVS12_04310 1405884 1406789 - hypothetical protein gene gene4309 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04310 VSVS12_04311 VSVS12_04311 VSVS12_04311 1406926 1408551 + N-substituted formamide deformylase Hydrolyzes N-substituted formamides%2C but not amides. N- benzylformamide is the preferred substrate%2C while N-butylformamide is hydrolyzed at a much lower rate. Has very low activity towards allylformamide%2C N-(2-cyclohex-1-enylethyl)formamide and N-(alpha- methylbenzyl)formamide gene gene4310 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04311 VSVS12_04312 VSVS12_04312 VSVS12_04312 1408655 1409863 + hypothetical protein gene gene4311 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04312 VSVS12_04313 VSVS12_04313 VSVS12_04313 1409860 1409961 + hypothetical protein gene gene4312 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04313 VSVS12_04314 VSVS12_04314 VSVS12_04314 1410054 1410515 - hypothetical protein gene gene4313 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04314 VSVS12_04315 VSVS12_04315 VSVS12_04315 1410548 1411051 - hypothetical protein gene gene4314 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04315 VSVS12_04316 VSVS12_04316 VSVS12_04316 1411109 1411588 - hypothetical protein gene gene4315 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04316 VSVS12_04317 VSVS12_04317 VSVS12_04317 1411733 1412737 - Zinc transport protein ZntB Mediates efflux of zinc ions%3B Belongs to the CorA metal ion transporter (MIT) (TC 1. A. 35) family gene gene4316 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04317 VSVS12_04318 VSVS12_04318 VSVS12_04318 1412898 1414118 + Voltage-gated potassium channel K(+)-specific ion channel. May play a role in the defense against osmotic shock%3B Belongs to the potassium channel family%3B Contains 1 RCK N-terminal domain gene gene4317 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04318 VSVS12_04319 VSVS12_04319 VSVS12_04319 1414285 1415016 - Uridine phosphorylase Cleavage of guanosine or inosine to respective bases and sugar-1-phosphate molecules. Cleaves inosine%2C guanosine%2C and adenosine with a better efficiency than MTA%3B Belongs to the PNP/UDP phosphorylase family%3B KEGG: vpa:VPA1079 uridine phosphorylase gene gene4318 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04319 VSVS12_04320 VSVS12_04320 VSVS12_04320 1415323 1416003 + hypothetical protein gene gene4319 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04320 VSVS12_04321 VSVS12_04321 VSVS12_04321 1416088 1417293 - Putative nucleoside permease NupX Belongs to the concentrative nucleoside transporter (CNT) (TC 2. A. 41) family gene gene4320 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04321 VSVS12_04322 VSVS12_04322 VSVS12_04322 1417300 1417866 - NAD(P)H dehydrogenase (quinone) The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinons involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis. Belongs to the NAD(P)H dehydrogenase (quinone) family%3B KEGG: msm:MSMEG_0284 NAD(P)H dehydrogenase (quinone) gene gene4321 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04322 VSVS12_04323 VSVS12_04323 VSVS12_04323 1418289 1418603 + hypothetical protein gene gene4322 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04323 VSVS12_04324 VSVS12_04324 VSVS12_04324 1418566 1418814 + hypothetical protein gene gene4323 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04324 VSVS12_04325 VSVS12_04325 VSVS12_04325 1418828 1419361 + hypothetical protein gene gene4324 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04325 VSVS12_04326 VSVS12_04326 VSVS12_04326 1419455 1420354 - putative HTH-type transcriptional regulator LtrA Contains 1 HTH lysR-type DNA-binding domain gene gene4325 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04326 VSVS12_04327 VSVS12_04327 VSVS12_04327 1420797 1421009 - Cold shock-like protein CspA Contains 1 CSD (cold-shock) domain gene gene4326 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04327 VSVS12_04328 VSVS12_04328 VSVS12_04328 1421746 1422936 + Rod shape-determining protein RodA Required for the maintenance of the rod cell shape. Required for the expression of the enzymatic activity of the penicillin-binding protein 2 (PBP2) (By similarity)%3B Belongs to the SEDS family. RodA subfamily gene gene4327 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04328 VSVS12_04329 VSVS12_04329 VSVS12_04329 1423154 1423684 + UPF0098 protein YbhB Belongs to the UPF0098 family gene gene4328 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04329 VSVS12_04330 VSVS12_04330 VSVS12_04330 1423717 1424484 + hypothetical protein gene gene4329 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04330 VSVS12_04331 VSVS12_04331 VSVS12_04331 1424579 1425886 - putative metalloprotease Belongs to the peptidase M23B family%3B KEGG: son:SO_2842 murein DD-endopeptidase%3B Metalloendopeptidases gene gene4330 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04331 VSVS12_04332 VSVS12_04332 VSVS12_04332 1426097 1426396 - hypothetical protein gene gene4331 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04332 VSVS12_04333 VSVS12_04333 VSVS12_04333 1426471 1427100 - hypothetical protein gene gene4332 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04333 VSVS12_04334 VSVS12_04334 VSVS12_04334 1427207 1427638 + hypothetical protein gene gene4333 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04334 VSVS12_04335 VSVS12_04335 VSVS12_04335 1427719 1428381 + hypothetical protein gene gene4334 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04335 VSVS12_04336 VSVS12_04336 VSVS12_04336 1428899 1430269 + uncharacterized protein gene gene4335 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04336 VSVS12_04337 VSVS12_04337 VSVS12_04337 1430894 1432228 - RNA helicase ATP-binding RNA helicase involved in 40S ribosomal subunit biogenesis and is required for the normal formation of 18S rRNAs through pre-rRNA processing at A0%2C A1 and A2 sites. Required for vegetative growth (By similarity)%3B Belongs to the DEAD box helicase family. DDX49/DBP8 subfamily%3B Contains 1 helicase ATP-binding domain%3B Contains 1 helicase C-terminal domain%3B KEGG: mpt:Mpe_A2088 ATP-dependent RNA helicase RhlE gene gene4336 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04337 VSVS12_04338 VSVS12_04338 VSVS12_04338 1432552 1432800 + Major outer membrane lipoprotein Interacts with the peptidoglycan both covalently and noncovalently%3B Belongs to the Lpp family gene gene4337 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04338 VSVS12_04339 VSVS12_04339 mmsB mmsB 1433042 1433914 - 3-hydroxyisobutyrate dehydrogenase Belongs to the 3-hydroxyisobutyrate dehydrogenase family%3B KEGG: aay:WYH_01380 3-hydroxyisobutyrate dehydrogenase gene gene4338 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04339 VSVS12_04340 VSVS12_04340 VSVS12_04340 1434112 1434759 + Putative pyrophosphatase PpaX Belongs to the HAD-like hydrolase superfamily. PpaX family gene gene4339 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04340 VSVS12_04341 VSVS12_04341 VSVS12_04341 1435069 1435971 + UPF0194 membrane protein Belongs to the UPF0194 family gene gene4340 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04341 VSVS12_04342 VSVS12_04342 VSVS12_04342 1435974 1436900 + Hypophosphite import ATP-binding protein HtxD Part of the ABC transporter complex HtxBCDE involved in hypophosphite import. Responsible for energy coupling to the transport system (Probable)%3B Belongs to the ABC transporter superfamily. Phosphonates importer (TC 3. A. 1. 9. 1) family%3B Contains 1 ABC transporter domain gene gene4341 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04342 VSVS12_04343 VSVS12_04343 VSVS12_04343 1436900 1438000 + Inner membrane transport permease Belongs to the ABC-2 integral membrane protein family%3B Contains 1 ABC transmembrane type-2 domain gene gene4342 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04343 VSVS12_04344 VSVS12_04344 VSVS12_04344 1438028 1438969 - hypothetical protein gene gene4343 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04344 VSVS12_04345 VSVS12_04345 VSVS12_04345 1439216 1439839 + Chloramphenicol O-acetyltransferase This enzyme is an effector of chloramphenicol resistance in bacteria. Belongs to the transferase hexapeptide repeat family%3B KEGG: ptt:VY86_08795 chloramphenicol O-acetyltransferase type B gene gene4344 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04345 VSVS12_04346 VSVS12_04346 VSVS12_04346 1439999 1440883 + hypothetical protein gene gene4345 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04346 VSVS12_04347 VSVS12_04347 VSVS12_04347 1441152 1441340 + hypothetical protein gene gene4346 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04347 VSVS12_04348 VSVS12_04348 VSVS12_04348 1441420 1441608 + hypothetical protein gene gene4347 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04348 VSVS12_04349 VSVS12_04349 VSVS12_04349 1441688 1441876 + hypothetical protein gene gene4348 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04349 VSVS12_04350 VSVS12_04350 VSVS12_04350 1441956 1442144 + hypothetical protein gene gene4349 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04350 VSVS12_04351 VSVS12_04351 VSVS12_04351 1442224 1442412 + hypothetical protein gene gene4350 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04351 VSVS12_04352 VSVS12_04352 VSVS12_04352 1443205 1443393 + hypothetical protein gene gene4351 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04352 VSVS12_04353 VSVS12_04353 VSVS12_04353 1443472 1443660 + hypothetical protein gene gene4352 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04353 VSVS12_04354 VSVS12_04354 VSVS12_04354 1443740 1443928 + hypothetical protein gene gene4353 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04354 VSVS12_04355 VSVS12_04355 VSVS12_04355 1444007 1444225 + hypothetical protein gene gene4354 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04355 VSVS12_04356 VSVS12_04356 VSVS12_04356 1444563 1444772 + hypothetical protein gene gene4355 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04356 VSVS12_04357 VSVS12_04357 VSVS12_04357 1444841 1445062 + hypothetical protein gene gene4356 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04357 VSVS12_04358 VSVS12_04358 VSVS12_04358 1445283 1446920 + L-carnitine/gamma-butyrobetaine antiporter Catalyzes the exchange of L-carnitine for gamma- butyrobetaine and related betaines%3B Belongs to the BCCT transporter (TC 2. A. 15) family. CaiT subfamily gene gene4357 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04358 VSVS12_04359 VSVS12_04359 VSVS12_04359 1447222 1447809 - UPF0750 membrane protein YdeO Belongs to the UPF0750 family gene gene4358 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04359 VSVS12_04360 VSVS12_04360 VSVS12_04360 1447944 1448861 - putative L%2CD-transpeptidase YcfS Responsible%2C at least in part%2C for anchoring of the major outer membrane lipoprotein (Lpp%2C also known as the Braun lipoprotein) to the peptidoglycan via a meso-diaminopimelyl-L-Lys- bond on the terminal residue of Lpp%3B Belongs to the YkuD family%3B Contains 1 LysM repeat gene gene4359 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04360 VSVS12_04361 VSVS12_04361 VSVS12_04361 1448858 1450309 - Deoxyribodipyrimidine photo-lyase Involved in repair of UV radiation-induced DNA damage. Catalyzes the light-dependent monomerization (300-600 nm) of cyclobutyl pyrimidine dimers (in cis-syn configuration)%2C which are formed between adjacent bases on the same DNA strand upon exposure to ultraviolet radiation. Belongs to the DNA photolyase class-1 family%3B Contains 1 photolyase/cryptochrome alpha/beta domain%3B KEGG: vch:VCA0057 deoxyribodipyrimidine photo-lyase gene gene4360 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04361 VSVS12_04362 VSVS12_04362 VSVS12_04362 1450387 1451187 - HTH-type transcriptional repressor BluR Controls the expression of several small proteins that may play a role in biofilm maturation. Binds to and represses the operator of the ycgZ-ymgA-ariR-ymgC operon and also regulates ynaK. Binding is antagonized by BluF upon blue light (470 nm) irradiation. Blue light may increase the affinity of BluF for BluR%2C allowing it to be released from its operator%3B Contains 1 HTH merR-type DNA-binding domain gene gene4361 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04362 VSVS12_04363 VSVS12_04363 VSVS12_04363 1451177 1452127 - uncharacterized protein gene gene4362 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04363 VSVS12_04364 VSVS12_04364 VSVS12_04364 1452518 1453228 + Purine-nucleoside phosphorylase Belongs to the PNP/UDP phosphorylase family%3B KEGG: eco:b4384 purine-nucleoside phosphorylase gene gene4363 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04364 VSVS12_04365 VSVS12_04365 VSVS12_04365 1453473 1454984 + hypothetical protein gene gene4364 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04365 VSVS12_04366 VSVS12_04366 VSVS12_04366 1455108 1456577 + hypothetical protein gene gene4365 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04366 VSVS12_04367 VSVS12_04367 VSVS12_04367 1456574 1458157 + uncharacterized protein Contains 1 GGDEF domain gene gene4366 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04367 VSVS12_04368 VSVS12_04368 VSVS12_04368 1458250 1458666 + Inner membrane protein To E. coli YibI gene gene4367 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04368 VSVS12_04369 VSVS12_04369 VSVS12_04369 1458669 1459799 + Inner membrane protein YiaV Belongs to the membrane fusion protein (MFP) (TC 8. A. 1) family gene gene4368 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04369 VSVS12_04370 VSVS12_04370 VSVS12_04370 1460233 1460781 + UPF0397 protein Belongs to the UPF0397 family gene gene4369 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04370 VSVS12_04371 VSVS12_04371 VSVS12_04371 1460788 1462482 + Putative ABC transporter ATP-binding protein Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system (By similarity)%3B Belongs to the ABC transporter superfamily%3B Contains 2 ABC transporter domains%3B KEGG: vvu:VV2_1533 energy-coupling factor transport system ATP-binding protein%3B Acting on acid anhydrides%3B catalyzing transmembrane movement of substances gene gene4370 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04371 VSVS12_04372 VSVS12_04372 VSVS12_04372 1462479 1463315 + hypothetical protein gene gene4371 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04372 VSVS12_04373 VSVS12_04373 VSVS12_04373 3 191 - hypothetical protein gene gene4372 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04373 VSVS12_04374 VSVS12_04374 VSVS12_04374 154 441 - hypothetical protein gene gene4373 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04374 VSVS12_04375 VSVS12_04375 VSVS12_04375 1278 1586 + hypothetical protein gene gene4374 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04375 VSVS12_04376 VSVS12_04376 VSVS12_04376 1641 1985 - Putative transposase YncI Belongs to the transposase 11 family gene gene4375 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04376 VSVS12_04377 VSVS12_04377 VSVS12_04377 1951 2664 - Putative transposase YncI Belongs to the transposase 11 family gene gene4376 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04377 VSVS12_04378 VSVS12_04378 VSVS12_04378 2761 2949 + hypothetical protein gene gene4377 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04378 VSVS12_04379 VSVS12_04379 VSVS12_04379 2965 3198 + hypothetical protein gene gene4378 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04379 VSVS12_04380 VSVS12_04380 VSVS12_04380 3195 3590 + hypothetical protein gene gene4379 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04380 VSVS12_04381 VSVS12_04381 VSVS12_04381 3590 5749 + DNA topoisomerase Releases the supercoiling and torsional tension of DNA%2C which is introduced during the DNA replication and transcription%2C by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme%2C resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand%2C thus removing DNA supercoils. Finally%2C in the religation step%2C the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone. TOP3 is a potent decatenase%3B Belongs to the type IA topoisomerase family%3B Contains 1 Toprim domain%3B KEGG: eco:b1763 DNA topoisomerase III gene gene4380 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04381 VSVS12_04382 VSVS12_04382 VSVS12_04382 5746 6297 + hypothetical protein gene gene4381 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04382 VSVS12_04383 VSVS12_04383 VSVS12_04383 6396 7166 + hypothetical protein gene gene4382 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04383 VSVS12_04384 VSVS12_04384 VSVS12_04384 7168 7395 + hypothetical protein gene gene4383 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04384 VSVS12_04385 VSVS12_04385 VSVS12_04385 7392 8081 + hypothetical protein gene gene4384 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04385 VSVS12_04386 VSVS12_04386 VSVS12_04386 8078 9715 + hypothetical protein gene gene4385 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04386 VSVS12_04387 VSVS12_04387 VSVS12_04387 9828 10199 + hypothetical protein gene gene4386 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04387 VSVS12_04388 VSVS12_04388 VSVS12_04388 10384 10845 + hypothetical protein gene gene4387 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04388 VSVS12_04389 VSVS12_04389 VSVS12_04389 11222 12331 - hypothetical protein gene gene4388 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04389 VSVS12_04390 VSVS12_04390 VSVS12_04390 12331 13236 - Trehalose/maltose transport system permease protein MalG Part of the ABC transporter complex MalEFGK involved in trehalose/maltose import. Responsible for the translocation of the substrate across the membrane%3B Belongs to the binding-protein-dependent transport system permease family%3B Contains 1 ABC transmembrane type-1 domain gene gene4389 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04390 VSVS12_04391 VSVS12_04391 VSVS12_04391 13236 14105 - putative ABC transporter permease protein MG188 like protein Probably part of a binding-protein-dependent transport system. Probably responsible for the translocation of the substrate across the membrane. Belongs to the binding-protein-dependent transport system permease family. MalFG subfamily%3B Contains 1 ABC transmembrane type-1 domain gene gene4390 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04391 VSVS12_04392 VSVS12_04392 VSVS12_04392 14105 15181 - Phosphonates import ATP-binding protein PhnC Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system%3B Belongs to the ABC transporter superfamily. Phosphonates importer (TC 3. A. 1. 9. 1) family%3B Contains 1 ABC transporter domain gene gene4391 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04392 VSVS12_04393 VSVS12_04393 VSVS12_04393 15370 16200 + Glycerophosphodiester phosphodiesterase Phosphatidylglycerol phospholipase required for the removal of excess phosphatidylglycerol (PG) via a phospholipase C- type degradation mechanism%3B Belongs to the glycerophosphoryl diester phosphodiesterase family%3B Contains 1 GP-PDE domain%3B KEGG: tsa:AciPR4_3634 glycerophosphoryl diester phosphodiesterase gene gene4392 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04393 VSVS12_04394 VSVS12_04394 VSVS12_04394 16200 17258 + uncharacterized protein Belongs to the ROK (NagC/XylR) family gene gene4393 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04394 VSVS12_04395 VSVS12_04395 VSVS12_04395 17394 18404 + UDP-glucose 4-epimerase Involved in the metabolism of galactose. Catalyzes the conversion of UDP-galactose (UDP-Gal) to UDP-glucose (UDP-Glc) through a mechanism involving the transient reduction of NAD (By similarity)%3B Belongs to the NAD(P)-dependent epimerase/dehydratase family%3B KEGG: eco:b0759 UDP-glucose 4-epimerase gene gene4394 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04395 VSVS12_04396 VSVS12_04396 galT galT 18456 19505 + UDP-glucose--hexose-1-phosphate uridylyltransferase Belongs to the galactose-1-phosphate uridylyltransferase type 1 family%3B KEGG: vvu:VV1_1771 UDPglucose--hexose-1-phosphate uridylyltransferase gene gene4395 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04396 VSVS12_04397 VSVS12_04397 VSVS12_04397 19656 20507 + hypothetical protein gene gene4396 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04397 VSVS12_04398 VSVS12_04398 VSVS12_04398 20554 22011 - hypothetical protein gene gene4397 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04398 VSVS12_04399 VSVS12_04399 VSVS12_04399 22013 23059 - hypothetical protein gene gene4398 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04399 VSVS12_04400 VSVS12_04400 VSVS12_04400 23487 23885 + hypothetical protein gene gene4399 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04400 VSVS12_04401 VSVS12_04401 VSVS12_04401 24026 24577 + hypothetical protein gene gene4400 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04401 VSVS12_04402 VSVS12_04402 VSVS12_04402 24587 24760 + hypothetical protein gene gene4401 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04402 VSVS12_04403 VSVS12_04403 VSVS12_04403 25164 25571 + hypothetical protein gene gene4402 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04403 VSVS12_04404 VSVS12_04404 VSVS12_04404 25704 26225 + hypothetical protein gene gene4403 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04404 VSVS12_04405 VSVS12_04405 VSVS12_04405 26287 26676 + hypothetical protein gene gene4404 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04405 VSVS12_04406 VSVS12_04406 VSVS12_04406 26750 27079 + hypothetical protein gene gene4405 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04406 VSVS12_04407 VSVS12_04407 VSVS12_04407 27165 27497 + hypothetical protein gene gene4406 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04407 VSVS12_04408 VSVS12_04408 VSVS12_04408 27580 27819 + hypothetical protein gene gene4407 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04408 VSVS12_04409 VSVS12_04409 VSVS12_04409 27988 28902 + hypothetical protein gene gene4408 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04409 VSVS12_04410 VSVS12_04410 VSVS12_04410 28964 29251 + hypothetical protein gene gene4409 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04410 VSVS12_04411 VSVS12_04411 VSVS12_04411 29443 30693 + hypothetical protein gene gene4410 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04411 VSVS12_04412 VSVS12_04412 VSVS12_04412 30690 32213 + hypothetical protein gene gene4411 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04412 VSVS12_04413 VSVS12_04413 VSVS12_04413 32213 33373 + hypothetical protein gene gene4412 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04413 VSVS12_04414 VSVS12_04414 VSVS12_04414 33370 34047 + hypothetical protein gene gene4413 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04414 VSVS12_04415 VSVS12_04415 VSVS12_04415 34044 35672 + Type II secretion system protein E Involved in a type II secretion system (T2SS%2C formerly general secretion pathway%2C GSP) for the export of proteins. Required for the translocation of pectate lyases and cellulases across the outer membrane. Belongs to the GSP E family gene gene4414 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04415 VSVS12_04416 VSVS12_04416 VSVS12_04416 35656 36648 + hypothetical protein gene gene4415 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04416 VSVS12_04417 VSVS12_04417 VSVS12_04417 36692 37207 + hypothetical protein gene gene4416 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04417 VSVS12_04418 VSVS12_04418 VSVS12_04418 37207 38676 + hypothetical protein gene gene4417 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04418 VSVS12_04419 VSVS12_04419 VSVS12_04419 38689 39192 + hypothetical protein gene gene4418 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04419 VSVS12_04420 VSVS12_04420 VSVS12_04420 39246 39461 + hypothetical protein gene gene4419 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04420 VSVS12_04421 VSVS12_04421 VSVS12_04421 39551 40543 + hypothetical protein gene gene4420 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04421 VSVS12_04422 VSVS12_04422 VSVS12_04422 40944 41219 + SPBc2 prophage-derived DNA-binding protein HU Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it%2C and thus to prevent its denaturation under extreme environmental conditions%3B Belongs to the bacterial histone-like protein family gene gene4421 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04422 VSVS12_04423 VSVS12_04423 VSVS12_04423 41547 42206 + hypothetical protein gene gene4422 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04423 VSVS12_04424 VSVS12_04424 VSVS12_04424 42203 42868 + hypothetical protein gene gene4423 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04424 VSVS12_04425 VSVS12_04425 VSVS12_04425 42838 43350 + hypothetical protein gene gene4424 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04425 VSVS12_04426 VSVS12_04426 VSVS12_04426 43360 43764 + hypothetical protein gene gene4425 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04426 VSVS12_04427 VSVS12_04427 VSVS12_04427 43806 44003 + hypothetical protein gene gene4426 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04427 VSVS12_04428 VSVS12_04428 VSVS12_04428 43981 44142 + hypothetical protein gene gene4427 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04428 VSVS12_04429 VSVS12_04429 VSVS12_04429 44204 46375 + hypothetical protein gene gene4428 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04429 VSVS12_04430 VSVS12_04430 VSVS12_04430 46372 47022 + hypothetical protein gene gene4429 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04430 VSVS12_04431 VSVS12_04431 VSVS12_04431 47092 47670 - hypothetical protein gene gene4430 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04431 VSVS12_04432 VSVS12_04432 VSVS12_04432 47639 47917 - hypothetical protein gene gene4431 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04432 VSVS12_04433 VSVS12_04433 VSVS12_04433 48066 48368 + hypothetical protein gene gene4432 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04433 VSVS12_04434 VSVS12_04434 VSVS12_04434 48365 48625 + hypothetical protein gene gene4433 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04434 VSVS12_04435 VSVS12_04435 VSVS12_04435 48622 48966 + hypothetical protein gene gene4434 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04435 VSVS12_04436 VSVS12_04436 VSVS12_04436 48971 49300 + hypothetical protein gene gene4435 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04436 VSVS12_04437 VSVS12_04437 VSVS12_04437 49311 49724 + hypothetical protein gene gene4436 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04437 VSVS12_04438 VSVS12_04438 VSVS12_04438 49717 50070 + hypothetical protein gene gene4437 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04438 VSVS12_04439 VSVS12_04439 VSVS12_04439 50067 50702 + hypothetical protein gene gene4438 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04439 VSVS12_04440 VSVS12_04440 VSVS12_04440 50702 51550 + hypothetical protein gene gene4439 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04440 VSVS12_04441 VSVS12_04441 VSVS12_04441 51543 52943 + hypothetical protein gene gene4440 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04441 VSVS12_04442 VSVS12_04442 VSVS12_04442 52930 53343 + hypothetical protein gene gene4441 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04442 VSVS12_04443 VSVS12_04443 VSVS12_04443 53343 56057 + hypothetical protein gene gene4442 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04443 VSVS12_04444 VSVS12_04444 VSVS12_04444 56054 57022 + hypothetical protein gene gene4443 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04444 VSVS12_04445 VSVS12_04445 VSVS12_04445 57039 58298 + hypothetical protein gene gene4444 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04445 VSVS12_04446 VSVS12_04446 VSVS12_04446 58298 58573 + hypothetical protein gene gene4445 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04446 VSVS12_04447 VSVS12_04447 VSVS12_04447 58567 60159 + hypothetical protein gene gene4446 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04447 VSVS12_04448 VSVS12_04448 VSVS12_04448 60205 60390 - hypothetical protein gene gene4447 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04448 VSVS12_04449 VSVS12_04449 VSVS12_04449 60538 61287 + hypothetical protein gene gene4448 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04449 VSVS12_04450 VSVS12_04450 VSVS12_04450 61292 61366 - tRNA-Gly tRNA gene4449 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04450 VSVS12_04451 VSVS12_04451 VSVS12_04451 61728 62018 - hypothetical protein gene gene4450 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04451 VSVS12_04452 VSVS12_04452 VSVS12_04452 62091 62342 + hypothetical protein gene gene4451 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04452 VSVS12_04453 VSVS12_04453 VSVS12_04453 62339 62515 + hypothetical protein gene gene4452 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04453 VSVS12_04454 VSVS12_04454 VSVS12_04454 62705 63181 - hypothetical protein gene gene4453 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04454 VSVS12_04455 VSVS12_04455 VSVS12_04455 63191 63538 - hypothetical protein gene gene4454 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04455 VSVS12_04456 VSVS12_04456 VSVS12_04456 63540 64460 - hypothetical protein gene gene4455 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04456 VSVS12_04457 VSVS12_04457 trmY trmY 65219 65821 - tRNA (pseudouridine(54)-N(1))-methyltransferase Belongs to the methyltransferase superfamily. TrmY family%3B KEGG: vtu:IX91_23425 tRNA (pseudouridine54-N1)-methyltransferase gene gene4456 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04457 VSVS12_04458 VSVS12_04458 VSVS12_04458 65889 66323 - Regulatory protein RecX Modulates RecA activity%3B Belongs to the RecX family gene gene4457 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04458 VSVS12_04459 VSVS12_04459 VSVS12_04459 67414 67809 + hypothetical protein gene gene4458 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04459 VSVS12_04460 VSVS12_04460 VSVS12_04460 67802 68014 + hypothetical protein gene gene4459 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04460 VSVS12_04461 VSVS12_04461 VSVS12_04461 68082 68612 + UPF0758 protein Belongs to the UPF0758 family gene gene4460 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04461 VSVS12_04462 VSVS12_04462 VSVS12_04462 68696 69259 + hypothetical protein gene gene4461 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04462 VSVS12_04463 VSVS12_04463 VSVS12_04463 69259 70344 + hypothetical protein gene gene4462 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04463 VSVS12_04464 VSVS12_04464 VSVS12_04464 70430 71020 + hypothetical protein gene gene4463 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04464 VSVS12_04465 VSVS12_04465 VSVS12_04465 71017 73299 + DNA topoisomerase KEGG: psp:PSPPH_0752 DNA topoisomerase III gene gene4464 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04465 VSVS12_04466 VSVS12_04466 VSVS12_04466 73366 73713 + hypothetical protein gene gene4465 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04466 VSVS12_04467 VSVS12_04467 VSVS12_04467 73778 74266 + hypothetical protein gene gene4466 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04467 VSVS12_04468 VSVS12_04468 VSVS12_04468 74263 74583 + hypothetical protein gene gene4467 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04468 VSVS12_04469 VSVS12_04469 VSVS12_04469 74602 74787 + hypothetical protein gene gene4468 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04469 VSVS12_04470 VSVS12_04470 VSVS12_04470 75149 76129 - hypothetical protein gene gene4469 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04470 VSVS12_04471 VSVS12_04471 VSVS12_04471 76140 77396 - hypothetical protein gene gene4470 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04471 VSVS12_04472 VSVS12_04472 VSVS12_04472 77943 78785 - Replication protein RepA This protein is essential for plasmid replicatio%3B it is involved in copy control functions%3B Belongs to the initiator RepB protein family gene gene4471 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04472 VSVS12_04473 VSVS12_04473 VSVS12_04473 79040 79378 - hypothetical protein gene gene4472 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04473 VSVS12_04474 VSVS12_04474 VSVS12_04474 80194 80697 + hypothetical protein gene gene4473 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04474 VSVS12_04475 VSVS12_04475 VSVS12_04475 80757 81965 + hypothetical protein gene gene4474 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04475 VSVS12_04476 VSVS12_04476 VSVS12_04476 81940 83529 + hypothetical protein gene gene4475 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04476 VSVS12_04477 VSVS12_04477 VSVS12_04477 83526 84107 + hypothetical protein gene gene4476 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04477 VSVS12_04478 VSVS12_04478 VSVS12_04478 84076 84744 + hypothetical protein gene gene4477 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04478 VSVS12_04479 VSVS12_04479 VSVS12_04479 84765 85754 + hypothetical protein gene gene4478 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04479 VSVS12_04480 VSVS12_04480 VSVS12_04480 86785 87111 + hypothetical protein gene gene4479 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04480 VSVS12_04481 VSVS12_04481 VSVS12_04481 87108 87320 + hypothetical protein gene gene4480 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04481 VSVS12_04482 VSVS12_04482 VSVS12_04482 87346 88116 + hypothetical protein gene gene4481 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04482 VSVS12_04483 VSVS12_04483 VSVS12_04483 88133 88246 + hypothetical protein gene gene4482 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04483 VSVS12_04484 VSVS12_04484 VSVS12_04484 88246 88506 + hypothetical protein gene gene4483 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04484 VSVS12_04485 VSVS12_04485 VSVS12_04485 88523 89530 + Nucleoid-associated protein Belongs to the YejK family gene gene4484 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04485 VSVS12_04486 VSVS12_04486 VSVS12_04486 90475 90744 + hypothetical protein gene gene4485 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04486 VSVS12_04487 VSVS12_04487 VSVS12_04487 90877 91461 + hypothetical protein gene gene4486 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04487 VSVS12_04488 VSVS12_04488 VSVS12_04488 91473 91715 - hypothetical protein gene gene4487 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04488 VSVS12_04489 VSVS12_04489 VSVS12_04489 91948 92121 + hypothetical protein gene gene4488 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04489 VSVS12_04490 VSVS12_04490 VSVS12_04490 92506 92760 + Antitoxin YefM Antitoxin component of a toxin-antitoxin (TA) module. Antitoxin that counteracts the effect of the YoeB mRNA interferase. YefM binds to the promoter region of the yefM-yeoB operon to repress transcription%2C YeoB acts as a corepressor (By similarity)%3B Belongs to the phD/YefM antitoxin family gene gene4489 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04490 VSVS12_04491 VSVS12_04491 yoeB yoeB 92753 93022 + Toxin RelK Toxic component of a toxin-antitoxin (TA) module. Has RNase activity and preferentially cleaves at the 3'-end of purine ribonucleotides (By similarity)%3B Belongs to the YoeB family%3B KEGG: vvy:VV1793 toxin YoeB%3B Acting on ester bonds gene gene4490 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04491 VSVS12_04492 VSVS12_04492 VSVS12_04492 93034 93597 - Transposon resolvase Resolvase catalyzes the resolution (a site-specific recombination) of the cointegrated replicon to yield the final transposition products. Belongs to the site-specific recombinase resolvase family%3B Contains 1 resolvase/invertase-type recombinase catalytic domain gene gene4491 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04492 VSVS12_04493 VSVS12_04493 VSVS12_04493 93868 94011 + hypothetical protein gene gene4492 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04493 VSVS12_04494 VSVS12_04494 VSVS12_04494 94048 95256 - Transposase for insertion sequence element IS1201 Required for the transposition of the insertion element. Belongs to the transposase mutator family gene gene4493 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04494 VSVS12_04495 VSVS12_04495 VSVS12_04495 95528 97303 - hypothetical protein gene gene4494 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04495 VSVS12_04496 VSVS12_04496 VSVS12_04496 97588 98379 - Putative ATP-binding protein in insertion sequence Belongs to the IS21/IS1162 putative ATP-binding protein family gene gene4495 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04496 VSVS12_04497 VSVS12_04497 VSVS12_04497 98376 99374 - Putative transposase for insertion sequence element IS5376 Involved in the transposition of the insertion sequence%3B Belongs to the transposase IS21/IS408/IS1162 family%3B Contains 1 HTH IS21-type DNA-binding domain%3B Contains 1 integrase catalytic domain gene gene4496 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04497 VSVS12_04498 VSVS12_04498 VSVS12_04498 100112 100507 - hypothetical protein gene gene4497 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04498 VSVS12_04499 VSVS12_04499 VSVS12_04499 100750 100908 + hypothetical protein gene gene4498 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04499 VSVS12_04500 VSVS12_04500 VSVS12_04500 101170 102087 - hypothetical protein gene gene4499 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04500 VSVS12_04501 VSVS12_04501 VSVS12_04501 102050 102337 - hypothetical protein gene gene4500 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04501 VSVS12_04502 VSVS12_04502 VSVS12_04502 103173 103481 + hypothetical protein gene gene4501 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04502 VSVS12_04503 VSVS12_04503 VSVS12_04503 103446 104567 - Putative transposase YncI Belongs to the transposase 11 family gene gene4502 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04503 VSVS12_04504 VSVS12_04504 VSVS12_04504 104664 104852 + hypothetical protein gene gene4503 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04504 VSVS12_04505 VSVS12_04505 VSVS12_04505 104868 105101 + hypothetical protein gene gene4504 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04505 VSVS12_04506 VSVS12_04506 VSVS12_04506 105098 105493 + hypothetical protein gene gene4505 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04506 VSVS12_04507 VSVS12_04507 VSVS12_04507 105493 107652 + DNA topoisomerase Releases the supercoiling and torsional tension of DNA%2C which is introduced during the DNA replication and transcription%2C by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme%2C resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand%2C thus removing DNA supercoils. Finally%2C in the religation step%2C the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone. TOP3 is a potent decatenase%3B Belongs to the type IA topoisomerase family%3B Contains 1 Toprim domain%3B KEGG: eco:b1763 DNA topoisomerase III gene gene4506 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04507 VSVS12_04508 VSVS12_04508 VSVS12_04508 107649 108200 + hypothetical protein gene gene4507 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04508 VSVS12_04509 VSVS12_04509 VSVS12_04509 108299 109069 + hypothetical protein gene gene4508 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04509 VSVS12_04510 VSVS12_04510 VSVS12_04510 109071 109298 + hypothetical protein gene gene4509 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04510 VSVS12_04511 VSVS12_04511 VSVS12_04511 109295 109984 + hypothetical protein gene gene4510 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04511 VSVS12_04512 VSVS12_04512 VSVS12_04512 109981 111618 + hypothetical protein gene gene4511 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04512 VSVS12_04513 VSVS12_04513 VSVS12_04513 111731 112102 + hypothetical protein gene gene4512 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04513 VSVS12_04514 VSVS12_04514 VSVS12_04514 112287 112748 + hypothetical protein gene gene4513 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04514 VSVS12_04515 VSVS12_04515 VSVS12_04515 113141 114235 - hypothetical protein gene gene4514 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04515 VSVS12_04516 VSVS12_04516 VSVS12_04516 114235 115140 - Trehalose/maltose transport system permease protein MalG Part of the ABC transporter complex MalEFGK involved in trehalose/maltose import. Responsible for the translocation of the substrate across the membrane%3B Belongs to the binding-protein-dependent transport system permease family%3B Contains 1 ABC transmembrane type-1 domain gene gene4515 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04516 VSVS12_04517 VSVS12_04517 VSVS12_04517 115140 116009 - putative ABC transporter permease protein MG188 like protein Probably part of a binding-protein-dependent transport system. Probably responsible for the translocation of the substrate across the membrane. Belongs to the binding-protein-dependent transport system permease family. MalFG subfamily%3B Contains 1 ABC transmembrane type-1 domain gene gene4516 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04517 VSVS12_04518 VSVS12_04518 VSVS12_04518 116009 117085 - Phosphonates import ATP-binding protein PhnC Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system%3B Belongs to the ABC transporter superfamily. Phosphonates importer (TC 3. A. 1. 9. 1) family%3B Contains 1 ABC transporter domain gene gene4517 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04518 VSVS12_04519 VSVS12_04519 VSVS12_04519 117274 118104 + Glycerophosphodiester phosphodiesterase Phosphatidylglycerol phospholipase required for the removal of excess phosphatidylglycerol (PG) via a phospholipase C- type degradation mechanism%3B Belongs to the glycerophosphoryl diester phosphodiesterase family%3B Contains 1 GP-PDE domain%3B KEGG: tsa:AciPR4_3634 glycerophosphoryl diester phosphodiesterase gene gene4518 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04519 VSVS12_04520 VSVS12_04520 VSVS12_04520 118104 119162 + uncharacterized protein Belongs to the ROK (NagC/XylR) family gene gene4519 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04520 VSVS12_04521 VSVS12_04521 VSVS12_04521 119298 120308 + UDP-glucose 4-epimerase Involved in the metabolism of galactose. Catalyzes the conversion of UDP-galactose (UDP-Gal) to UDP-glucose (UDP-Glc) through a mechanism involving the transient reduction of NAD (By similarity)%3B Belongs to the NAD(P)-dependent epimerase/dehydratase family%3B KEGG: eco:b0759 UDP-glucose 4-epimerase gene gene4520 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04521 VSVS12_04522 VSVS12_04522 VSVS12_04522 120360 121409 + UDP-glucose--hexose-1-phosphate uridylyltransferase Belongs to the galactose-1-phosphate uridylyltransferase type 1 family%3B KEGG: vvu:VV1_1771 UDPglucose--hexose-1-phosphate uridylyltransferase gene gene4521 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04522 VSVS12_04523 VSVS12_04523 VSVS12_04523 121560 122411 + hypothetical protein gene gene4522 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04523 VSVS12_04524 VSVS12_04524 VSVS12_04524 122458 123192 - hypothetical protein gene gene4523 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04524 VSVS12_04525 VSVS12_04525 VSVS12_04525 123177 123509 - hypothetical protein gene gene4524 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04525 VSVS12_04526 VSVS12_04526 VSVS12_04526 123734 123913 - hypothetical protein gene gene4525 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04526 VSVS12_04527 VSVS12_04527 VSVS12_04527 123915 124151 - hypothetical protein gene gene4526 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04527 VSVS12_04528 VSVS12_04528 VSVS12_04528 124144 124959 - hypothetical protein gene gene4527 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04528 VSVS12_04529 VSVS12_04529 VSVS12_04529 127019 127432 + hypothetical protein gene gene4528 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04529 VSVS12_04530 VSVS12_04530 VSVS12_04530 3 245 + Malate-2H(+)/Na(+)-lactate antiporter Couples proton uptake and Na(+) efflux to the substrate- product malate/lactate antiport%2C in an electroneutral malate- 2H(+)/Na(+)-lactate exchange. Plays a role in supporting growth to high density on malate at reduced protonmotive force. Belongs to the NhaC Na(+)/H(+) (TC 2. A. 35) antiporter family gene gene4547 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04530 VSVS12_04531 VSVS12_04531 VSVS12_04531 266 991 + Arginine/ornithine antiporter ArcD Uptake of arginine from the medium in exchange for ornithine%3B Belongs to the NhaC Na(+)/H(+) (TC 2. A. 35) antiporter family gene gene4548 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04531 VSVS12_04532 VSVS12_04532 VSVS12_04532 2120 2242 + Peroxiredoxin KEGG: vvu:VV1_1910 peroxiredoxin Q/BCP gene gene4549 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04532 VSVS12_04533 VSVS12_04533 VSVS12_04533 2307 2885 - Plasmid Partition par B protein Control of plasmid partitionin%3B required to recognize the cis-acting partition sites. Belongs to the ParB family gene gene4550 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04533 VSVS12_04534 VSVS12_04534 VSVS12_04534 3039 3197 - hypothetical protein gene gene4551 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04534 VSVS12_04535 VSVS12_04535 VSVS12_04535 3194 3382 - hypothetical protein gene gene4552 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04535 VSVS12_04536 VSVS12_04536 VSVS12_04536 3835 4341 - hypothetical protein gene gene4553 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04536 VSVS12_04537 VSVS12_04537 VSVS12_04537 5269 5562 - hypothetical protein gene gene4554 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04537 VSVS12_04538 VSVS12_04538 VSVS12_04538 5774 5962 + hypothetical protein gene gene4555 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04538 VSVS12_04539 VSVS12_04539 VSVS12_04539 6216 6839 + hypothetical protein gene gene4556 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04539 VSVS12_04540 VSVS12_04540 VSVS12_04540 6858 7325 + hypothetical protein gene gene4557 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04540 VSVS12_04541 VSVS12_04541 tnaA tnaA 7335 7574 - Tryptophanase Belongs to the beta-eliminating lyase family%3B KEGG: yen:YE0650 tryptophanase gene gene4558 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04541 VSVS12_04542 VSVS12_04542 VSVS12_04542 7923 8810 - Tryptophanase Belongs to the beta-eliminating lyase family%3B KEGG: eco:b3708 tryptophanase gene gene4559 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04542 VSVS12_04543 VSVS12_04543 VSVS12_04543 9234 9422 - hypothetical protein gene gene4560 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04543 VSVS12_04544 VSVS12_04544 VSVS12_04544 9442 9666 - hypothetical protein gene gene4561 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04544 VSVS12_04545 VSVS12_04545 ulaE ulaE 9681 10322 - L-ribulose-5-phosphate 3-epimerase Catalyzes the isomerization of L-xylulose-5-phosphate to L-ribulose-5-phosphate%3B Belongs to the L-ribulose-5-phosphate 3-epimerase family%3B KEGG: vvu:VV2_1085 L-ribulose-5-phosphate 3-epimerase gene gene4562 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04545 VSVS12_04546 VSVS12_04546 ulaD ulaD 10332 10976 - 3-dehydro-L-gulonate-6-phosphate decarboxylase Catalyzes the decarboxylation of 3-keto-L-gulonate-6-P into L-xylulose-5-P. May be involved in the utilization of 2%2C3- diketo-L-gulonate%3B Belongs to the HPS/KGPDC family. KGPDC subfamily%3B KEGG: mal:MAGa7310 3-dehydro-L-gulonate-6-phosphate decarboxylase gene gene4563 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04546 VSVS12_04547 VSVS12_04547 sgbE sgbE 11087 11800 - L-ribulose-5-phosphate 4-epimerase Belongs to the aldolase class II family. AraD/FucA subfamily%3B KEGG: spe:Spro_3939 L-ribulose-5-phosphate 4-epimerase gene gene4564 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04547 VSVS12_04548 VSVS12_04548 VSVS12_04548 11797 12264 - Protein-N(pi)-phosphohistidine--sugar phosphotransferase The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS)%2C a major carbohydrate active -transport system%2C catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in ascorbate transport (By similarity)%3B Contains 1 PTS EIIA type-2 domain%3B KEGG: dda:Dd703_0117 PTS system%2C ascorbate-specific IIA component gene gene4565 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04548 VSVS12_04549 VSVS12_04549 VSVS12_04549 12314 12568 - Protein-N(pi)-phosphohistidine--sugar phosphotransferase The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS)%2C a major carbohydrate active -transport system%2C catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in ascorbate transport (By similarity)%3B Contains 1 PTS EIIB type-2 domain%3B KEGG: yrb:UGYR_01865 PTS system%2C ascorbate-specific IIB component gene gene4566 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04549 VSVS12_04550 VSVS12_04550 VSVS12_04550 12598 14073 - Protein-N(pi)-phosphohistidine--sugar phosphotransferase The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS)%2C a major carbohydrate active- transport system%2C catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. This system is involved in ascorbate transport (By similarity)%3B Belongs to the UlaA family%3B KEGG: yrb:UGYR_01865 PTS system%2C ascorbate-specific IIB component gene gene4567 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04550 VSVS12_04551 VSVS12_04551 VSVS12_04551 14454 15209 + Glycerol-3-phosphate regulon repressor Repressor of the glycerol-3-phosphate regulon. Contains 1 HTH deoR-type DNA-binding domain gene gene4568 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04551 VSVS12_04552 VSVS12_04552 ulaG ulaG 15291 16358 + putative L-ascorbate-6-phosphate lactonase UlaG Probably catalyzes the hydrolysis of L-ascorbate-6-P into 3-keto-L-gulonate-6-P. Is essential for L-ascorbate utilization under anaerobic conditions%3B Belongs to the UlaG family%3B KEGG: hdu:HD1861 L-ascorbate 6-phosphate lactonase%3B Carboxylic ester hydrolases gene gene4569 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04552 VSVS12_04553 VSVS12_04553 VSVS12_04553 16434 18221 - Hemolysin ahh1 Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture by mechanisms not clearly defined. Belongs to the HlyA hemolysin family%3B Contains 1 ricin B-type lectin domain gene gene4570 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04553 VSVS12_04554 VSVS12_04554 VSVS12_04554 18327 19070 - hypothetical protein gene gene4571 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04554 VSVS12_04555 VSVS12_04555 VSVS12_04555 20055 21158 - Adenosine monophosphate-protein transferase SoFic Adenylyltransferase that mediates the addition of adenosine 5'-monophosphate (AMP) to specific residues of target proteins%3B Contains 1 fido domain gene gene4572 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04555 VSVS12_04556 VSVS12_04556 VSVS12_04556 21259 21801 - Putative transposon DNA-invertase bin3 Potential DNA invertase. Belongs to the site-specific recombinase resolvase family%3B Contains 1 resolvase/invertase-type recombinase catalytic domain gene gene4573 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04556 VSVS12_04557 VSVS12_04557 VSVS12_04557 21964 22581 - hypothetical protein gene gene4574 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04557 VSVS12_04558 VSVS12_04558 VSVS12_04558 23171 24250 - hypothetical protein gene gene4575 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04558 VSVS12_04559 VSVS12_04559 VSVS12_04559 25893 26693 + hypothetical protein gene gene4576 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04559 VSVS12_04560 VSVS12_04560 VSVS12_04560 27132 28016 - Glycine cleavage system transcriptional activator Regulatory protein for the glycine cleavage system operon (gcv). Mediates activation of gcv by glycine and repression by purines. GcvA is negatively autoregulated. Binds to three sites upstream of the gcv promoter (By similarity)%3B Contains 1 HTH lysR-type DNA-binding domain gene gene4577 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04560 VSVS12_04561 VSVS12_04561 VSVS12_04561 28141 29583 + Na(+)/H(+) antiporter NhaC Na(+)/H(+) antiporter. Involved in pH homeostasis and sodium extrusion%3B Belongs to the NhaC Na(+)/H(+) (TC 2. A. 35) antiporter family gene gene4578 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04561 VSVS12_04562 VSVS12_04562 VSVS12_04562 29576 30412 + hypothetical protein gene gene4579 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04562 VSVS12_04563 VSVS12_04563 VSVS12_04563 30651 30773 + Peroxiredoxin KEGG: vvu:VV1_1910 peroxiredoxin Q/BCP gene gene4580 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04563 VSVS12_04564 VSVS12_04564 VSVS12_04564 30838 31911 - Plasmid Partition par B protein Control of plasmid partitionin%3B required to recognize the cis-acting partition sites. Belongs to the ParB family gene gene4581 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04564 VSVS12_04565 VSVS12_04565 VSVS12_04565 31911 33110 - Putative replication protein gene gene4582 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04565 VSVS12_04566 VSVS12_04566 VSVS12_04566 33249 34049 - hypothetical protein gene gene4583 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04566 VSVS12_04567 VSVS12_04567 VSVS12_04567 34304 34492 + hypothetical protein gene gene4584 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04567 VSVS12_04568 VSVS12_04568 VSVS12_04568 34746 35369 + hypothetical protein gene gene4585 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04568 VSVS12_04569 VSVS12_04569 VSVS12_04569 35388 35855 + hypothetical protein gene gene4586 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04569 VSVS12_04570 VSVS12_04570 VSVS12_04570 35865 37340 - Tryptophanase Belongs to the beta-eliminating lyase family%3B KEGG: eco:b3708 tryptophanase gene gene4587 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04570 VSVS12_04571 VSVS12_04571 VSVS12_04571 37764 37952 - hypothetical protein gene gene4588 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04571 VSVS12_04572 VSVS12_04572 VSVS12_04572 37972 38853 - L-ribulose-5-phosphate 3-epimerase Catalyzes the isomerization of L-xylulose-5-phosphate to L-ribulose-5-phosphate%3B Belongs to the L-ribulose-5-phosphate 3-epimerase family%3B KEGG: vvu:VV2_1085 L-ribulose-5-phosphate 3-epimerase gene gene4589 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04572 VSVS12_04573 VSVS12_04573 VSVS12_04573 38863 39507 - 3-dehydro-L-gulonate-6-phosphate decarboxylase Catalyzes the decarboxylation of 3-keto-L-gulonate-6-P into L-xylulose-5-P. May be involved in the utilization of 2%2C3- diketo-L-gulonate%3B Belongs to the HPS/KGPDC family. KGPDC subfamily%3B KEGG: mal:MAGa7310 3-dehydro-L-gulonate-6-phosphate decarboxylase gene gene4590 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04573 VSVS12_04574 VSVS12_04574 araD araD 39617 39901 - L-ribulose-5-phosphate 4-epimerase Belongs to the aldolase class II family. AraD/FucA subfamily%3B KEGG: eam:EAMY_1894 L-ribulose-5-phosphate 4-epimerase gene gene4591 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04574 VSVS12_04575 VSVS12_04575 VSVS12_04575 39970 40329 - L-ribulose-5-phosphate 4-epimerase Belongs to the aldolase class II family. AraD/FucA subfamily%3B KEGG: spe:Spro_3939 L-ribulose-5-phosphate 4-epimerase gene gene4592 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04575 VSVS12_04576 VSVS12_04576 VSVS12_04576 40326 40793 - Protein-N(pi)-phosphohistidine--sugar phosphotransferase The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS)%2C a major carbohydrate active -transport system%2C catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in ascorbate transport (By similarity)%3B Contains 1 PTS EIIA type-2 domain%3B KEGG: dda:Dd703_0117 PTS system%2C ascorbate-specific IIA component gene gene4593 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04576 VSVS12_04577 VSVS12_04577 VSVS12_04577 40843 42603 - Protein-N(pi)-phosphohistidine--sugar phosphotransferase The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS)%2C a major carbohydrate active- transport system%2C catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. This system is involved in ascorbate transport (By similarity)%3B Belongs to the UlaA family%3B KEGG: yrb:UGYR_01865 PTS system%2C ascorbate-specific IIB component gene gene4594 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04577 VSVS12_04578 VSVS12_04578 VSVS12_04578 42984 43739 + Glycerol-3-phosphate regulon repressor Repressor of the glycerol-3-phosphate regulon. Contains 1 HTH deoR-type DNA-binding domain gene gene4595 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04578 VSVS12_04579 VSVS12_04579 VSVS12_04579 43821 44888 + putative L-ascorbate-6-phosphate lactonase UlaG Probably catalyzes the hydrolysis of L-ascorbate-6-P into 3-keto-L-gulonate-6-P. Is essential for L-ascorbate utilization under anaerobic conditions%3B Belongs to the UlaG family%3B KEGG: hdu:HD1861 L-ascorbate 6-phosphate lactonase%3B Carboxylic ester hydrolases gene gene4596 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04579 VSVS12_04580 VSVS12_04580 VSVS12_04580 44964 45836 - Hemolysin Bacterial hemolysin that causes cytolysis by forming heptameric pores in target host membranes%3B Belongs to the HlyA hemolysin family%3B Contains 1 ricin B-type lectin domain gene gene4597 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04580 VSVS12_04581 VSVS12_04581 VSVS12_04581 45866 46750 - Hemolysin ahh1 Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture by mechanisms not clearly defined. Belongs to the HlyA hemolysin family%3B Contains 1 ricin B-type lectin domain gene gene4598 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04581 VSVS12_04582 VSVS12_04582 VSVS12_04582 46856 47599 - hypothetical protein gene gene4599 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04582 VSVS12_04583 VSVS12_04583 VSVS12_04583 48581 49576 - Adenosine monophosphate-protein transferase SoFic Adenylyltransferase that mediates the addition of adenosine 5'-monophosphate (AMP) to specific residues of target proteins%3B Contains 1 fido domain gene gene4600 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04583 VSVS12_04584 VSVS12_04584 VSVS12_04584 49852 50325 - Putative transposon DNA-invertase bin3 Potential DNA invertase. Belongs to the site-specific recombinase resolvase family%3B Contains 1 resolvase/invertase-type recombinase catalytic domain gene gene4601 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04584 VSVS12_04585 VSVS12_04585 VSVS12_04585 50488 50784 - hypothetical protein gene gene4602 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04585 VSVS12_04586 VSVS12_04586 VSVS12_04586 51718 52035 - hypothetical protein gene gene4603 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04586 VSVS12_04587 VSVS12_04587 VSVS12_04587 52032 52139 - hypothetical protein gene gene4604 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04587 VSVS12_04588 VSVS12_04588 VSVS12_04588 52136 52393 - hypothetical protein gene gene4605 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04588 VSVS12_04589 VSVS12_04589 VSVS12_04589 52396 52764 - hypothetical protein gene gene4606 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04589 VSVS12_04590 VSVS12_04590 VSVS12_04590 1361 1588 + hypothetical protein gene gene4529 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04590 VSVS12_04591 VSVS12_04591 VSVS12_04591 1581 2465 + hypothetical protein gene gene4530 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04591 VSVS12_04592 VSVS12_04592 VSVS12_04592 2462 3124 + hypothetical protein gene gene4531 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04592 VSVS12_04593 VSVS12_04593 VSVS12_04593 3225 3557 + hypothetical protein gene gene4532 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04593 VSVS12_04594 VSVS12_04594 VSVS12_04594 3613 4377 - hypothetical protein gene gene4533 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04594 VSVS12_04595 VSVS12_04595 VSVS12_04595 4388 4999 - Resolvase Involved in plasmid partition. Belongs to the site-specific recombinase resolvase family%3B Contains 1 resolvase/invertase-type recombinase catalytic domain gene gene4534 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04595 VSVS12_04596 VSVS12_04596 VSVS12_04596 5256 5783 + hypothetical protein gene gene4535 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04596 VSVS12_04597 VSVS12_04597 VSVS12_04597 5827 6408 + hypothetical protein gene gene4536 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04597 VSVS12_04598 VSVS12_04598 VSVS12_04598 7505 7702 - hypothetical protein gene gene4537 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04598 VSVS12_04599 VSVS12_04599 VSVS12_04599 7713 7928 - hypothetical protein gene gene4538 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04599 VSVS12_04600 VSVS12_04600 VSVS12_04600 7934 8068 - hypothetical protein gene gene4539 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04600 VSVS12_04601 VSVS12_04601 VSVS12_04601 8207 8566 - hypothetical protein gene gene4540 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04601 VSVS12_04602 VSVS12_04602 VSVS12_04602 8563 9078 - hypothetical protein gene gene4541 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04602 VSVS12_04603 VSVS12_04603 VSVS12_04603 9879 10811 - hypothetical protein gene gene4542 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04603 VSVS12_04604 VSVS12_04604 VSVS12_04604 11021 11290 - hypothetical protein gene gene4543 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04604 VSVS12_04605 VSVS12_04605 VSVS12_04605 11300 14122 - putative tape measure protein Serves as a base for tail tube protein polymerization and acts as a template for tail length determination%3B Belongs to the P2likevirus tape measure protein family gene gene4544 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04605 VSVS12_04606 VSVS12_04606 VSVS12_04606 14115 14348 - hypothetical protein gene gene4545 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04606 VSVS12_04607 VSVS12_04607 VSVS12_04607 14345 14527 - hypothetical protein gene gene4546 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS12_04607