locus-tag	class	description
ITG12_00005	COG1074	ATP-dependent DNA helicase activity
ITG12_00065	COG3850	Histidine kinase
ITG12_00065	COG5002	protein histidine kinase activity
ITG12_00070	COG0745	RESPONSE REGULATOR receiver
ITG12_00075	COG0463	Glycosyl transferase, family 2
ITG12_00080	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
ITG12_00090	COG0840	transmembrane signaling receptor activity
ITG12_00095	COG2964	Protein conserved in bacteria
ITG12_00110	COG0446	pyridine nucleotide-disulphide oxidoreductase
ITG12_00135	COG1032	radical SAM domain protein
ITG12_00140	COG1716	ATPase activity
ITG12_00140	COG5001	Diguanylate cyclase
ITG12_00155	COG0583	DNA-binding transcription factor activity
ITG12_00160	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
ITG12_00170	COG2350	Protein conserved in bacteria
ITG12_00175	COG1607	acyl-coa hydrolase
ITG12_00200	COG1301	dicarboxylic acid transport
ITG12_00210	COG0159	tryptophan synthase activity
ITG12_00220	COG0134	indole-3-glycerol-phosphate synthase activity
ITG12_00220	COG0135	phosphoribosylanthranilate isomerase activity
ITG12_00230	COG0512	Glutamine amidotransferase of anthranilate synthase
ITG12_00235	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ITG12_00245	COG0613	PHP domain protein
ITG12_00250	COG0009	L-threonylcarbamoyladenylate synthase
ITG12_00260	COG1187	pseudouridine synthase activity
ITG12_00280	COG0417	DNA replication proofreading
ITG12_00285	COG2197	response regulator
ITG12_00290	COG0322	excinuclease ABC activity
ITG12_00330	COG0019	diaminopimelate decarboxylase activity
ITG12_00360	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ITG12_00365	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ITG12_00370	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ITG12_00390	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
ITG12_00400	COG0437	4 iron, 4 sulfur cluster binding
ITG12_00405	COG3301	Polysulphide reductase, NrfD
ITG12_00410	COG1138	Cytochrome C-type biogenesis protein
ITG12_00420	COG3088	subunit of a heme lyase
ITG12_00420	COG4235	cytochrome complex assembly
ITG12_00430	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ITG12_00455	COG2989	Protein conserved in bacteria
ITG12_00460	COG3108	Peptidase M15
ITG12_00465	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ITG12_00480	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
ITG12_00505	COG1846	Transcriptional regulator
ITG12_00510	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
ITG12_00515	COG0840	transmembrane signaling receptor activity
ITG12_00535	COG1448	Aminotransferase
ITG12_00540	COG2770	Histidine kinase
ITG12_00540	COG3437	response regulator, receiver
ITG12_00545	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ITG12_00555	COG1609	Transcriptional regulator
ITG12_00575	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ITG12_00590	COG0017	Asparaginyl-tRNA synthetase
ITG12_00600	COG0720	synthase
ITG12_00605	COG2197	response regulator
ITG12_00620	COG3300	MHYT domain
ITG12_00620	COG5001	Diguanylate cyclase
ITG12_00625	COG1760	l-serine dehydratase
ITG12_00630	COG0814	amino acid
ITG12_00635	COG0494	nUDIX hydrolase
ITG12_00645	COG2205	protein histidine kinase activity
ITG12_00645	COG0784	Response regulator, receiver
ITG12_00650	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ITG12_00665	COG3106	COG3106 Predicted ATPase
ITG12_00680	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ITG12_00760	COG2026	Addiction module toxin, RelE StbE family
ITG12_00790	COG0251	oxidation-reduction process
ITG12_01435	COG2026	Addiction module toxin, RelE StbE family
ITG12_01455	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
ITG12_01660	COG3738	Protein conserved in bacteria
ITG12_01665	COG3340	Belongs to the peptidase S51 family
ITG12_01685	COG0456	acetyltransferase
ITG12_01690	COG0471	metal ion transport
ITG12_01695	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ITG12_01695	COG4191	Histidine kinase
ITG12_01705	COG5001	Diguanylate cyclase
ITG12_01705	COG3300	MHYT domain
ITG12_01715	COG1280	lysine exporter protein (LysE YggA)
ITG12_01720	COG1328	CTP reductase activity
ITG12_01725	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
ITG12_01735	COG0861	Integral membrane protein TerC family
ITG12_01745	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
ITG12_01750	COG1028	Short-chain dehydrogenase reductase Sdr
ITG12_01755	COG3706	GGDEF domain
ITG12_01770	COG0814	amino acid
ITG12_01785	COG1120	ATPase activity
ITG12_01790	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ITG12_01800	COG4774	siderophore transport
ITG12_01810	COG1132	(ABC) transporter
ITG12_01815	COG1132	(ABC) transporter
ITG12_01820	COG2165	general secretion pathway protein
ITG12_01825	COG0583	DNA-binding transcription factor activity
ITG12_01850	COG0443	Heat shock 70 kDa protein
ITG12_01855	COG0443	Heat shock 70 kDa protein
ITG12_01895	COG3227	Zinc metalloprotease (Elastase)
ITG12_01905	COG0243	molybdopterin cofactor binding
ITG12_01910	COG0437	4 iron, 4 sulfur cluster binding
ITG12_01915	COG3302	dmso reductase anchor subunit
ITG12_01930	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
ITG12_01935	COG1643	Atp-dependent helicase
ITG12_01960	COG3063	Type IV pilus biogenesis stability protein PilW
ITG12_01965	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
ITG12_01995	COG0531	amino acid
ITG12_02000	COG1280	lysine exporter protein (LysE YggA)
ITG12_02005	COG0583	DNA-binding transcription factor activity
ITG12_02010	COG1560	Kdo2-lipid A biosynthetic process
ITG12_02025	COG1846	Transcriptional regulator
ITG12_02040	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
ITG12_02045	COG1280	lysine exporter protein (LysE YggA)
ITG12_02080	COG1115	amino acid carrier protein
ITG12_02110	COG1368	sulfuric ester hydrolase activity
ITG12_02115	COG0215	cysteine-tRNA ligase activity
ITG12_02120	COG0534	Mate efflux family protein
ITG12_02125	COG2113	Glycine betaine
ITG12_02130	COG4176	ABC-type proline glycine betaine transport system permease component
ITG12_02140	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
ITG12_02150	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
ITG12_02155	COG0456	acetyltransferase
ITG12_02160	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
ITG12_02165	COG0662	Cupin 2, conserved barrel domain protein
ITG12_02170	COG0527	aspartate kinase activity
ITG12_02175	COG1858	cytochrome C peroxidase
ITG12_02180	COG1404	Belongs to the peptidase S8 family
ITG12_02210	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
ITG12_02215	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
ITG12_02225	COG2814	Major facilitator Superfamily
ITG12_02230	COG0583	DNA-binding transcription factor activity
ITG12_02240	COG0446	pyridine nucleotide-disulphide oxidoreductase
ITG12_02250	COG1595	DNA-templated transcription, initiation
ITG12_02260	COG2918	glutathione biosynthetic process
ITG12_02265	COG1132	(ABC) transporter
ITG12_02270	COG1132	(ABC) transporter
ITG12_02290	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ITG12_02305	COG3976	FMN-binding domain protein
ITG12_02305	COG1053	succinate dehydrogenase
ITG12_02305	COG0431	NADPH-dependent FMN reductase
ITG12_02325	COG3290	protein histidine kinase activity
ITG12_02330	COG4565	transcriptional regulatory protein
ITG12_02335	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
ITG12_02340	COG0363	glucosamine-6-phosphate deaminase activity
ITG12_02345	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
ITG12_02380	COG3284	Transcriptional regulator
ITG12_02385	COG1012	belongs to the aldehyde dehydrogenase family
ITG12_02395	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ITG12_02400	COG2358	TRAP transporter, solute receptor (TAXI family
ITG12_02410	COG0814	amino acid
ITG12_02420	COG0730	response to heat
ITG12_02445	COG0456	acetyltransferase
ITG12_02455	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
ITG12_02460	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
ITG12_02570	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
ITG12_02575	COG0372	Belongs to the citrate synthase family
ITG12_02585	COG2828	Protein conserved in bacteria
ITG12_02610	COG0561	phosphatase activity
ITG12_02615	COG0602	queuosine metabolic process
ITG12_02625	COG3706	GGDEF domain
ITG12_02670	COG0840	transmembrane signaling receptor activity
ITG12_02675	COG1254	Belongs to the acylphosphatase family
ITG12_02680	COG2920	part of a sulfur-relay system
ITG12_02690	COG0670	Belongs to the BI1 family
ITG12_02695	COG1126	abc transporter atp-binding protein
ITG12_02700	COG0765	amino acid transport
ITG12_02705	COG4597	amino acid ABC transporter
ITG12_02710	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ITG12_02725	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ITG12_02750	COG3008	intermembrane lipid transfer
ITG12_02755	COG2995	paraquat-inducible protein a
ITG12_02760	COG1132	(ABC) transporter
ITG12_02765	COG1956	GAF domain-containing protein
ITG12_02770	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
ITG12_02785	COG0308	aminopeptidase N
ITG12_02795	COG2902	Dehydrogenase
ITG12_02820	COG0488	(ABC) transporter
ITG12_02835	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ITG12_02840	COG1067	ATP-dependent peptidase activity
ITG12_02845	COG3120	sequence-specific DNA binding
ITG12_02865	COG2801	Transposase and inactivated derivatives
ITG12_02880	COG0784	Response regulator, receiver
ITG12_02880	COG2205	protein histidine kinase activity
ITG12_02895	COG3278	Belongs to the heme-copper respiratory oxidase family
ITG12_02910	COG2010	Cytochrome c
ITG12_02920	COG2217	Heavy metal translocating P-type atpase
ITG12_02935	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ITG12_02940	COG0589	response to stress
ITG12_02965	COG3842	ATPase activity
ITG12_02975	COG1177	transmembrane transport
ITG12_02985	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
ITG12_02990	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
ITG12_03005	COG0437	4 iron, 4 sulfur cluster binding
ITG12_03010	COG0243	molybdopterin cofactor binding
ITG12_03010	COG3383	formate dehydrogenase (NAD+) activity
ITG12_03020	COG3381	protein complex oligomerization
ITG12_03040	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
ITG12_03045	COG0488	(ABC) transporter
ITG12_03060	COG4191	Histidine kinase
ITG12_03065	COG2204	response regulator
ITG12_03075	COG4662	Binding-protein-dependent transport system inner membrane component
ITG12_03080	COG3842	ATPase activity
ITG12_03090	COG0303	'Molybdopterin
ITG12_03100	COG1940	carbohydrate kinase activity
ITG12_03105	COG3148	PFAM DTW domain containing protein
ITG12_03150	COG0840	transmembrane signaling receptor activity
ITG12_03155	COG0791	NLP P60 protein
ITG12_03165	COG3706	GGDEF domain
ITG12_03170	COG2201	protein-glutamate methylesterase activity
ITG12_03175	COG3001	Fructosamine kinase
ITG12_03185	COG0307	riboflavin synthase, alpha
ITG12_03190	COG0534	Mate efflux family protein
ITG12_03200	COG1793	dna ligase
ITG12_03210	COG2885	chlorophyll binding
ITG12_03220	COG0489	protein tyrosine kinase activity
ITG12_03230	COG2204	response regulator
ITG12_03240	COG0438	transferase activity, transferring glycosyl groups
ITG12_03270	COG0438	transferase activity, transferring glycosyl groups
ITG12_03275	COG1215	transferase activity, transferring glycosyl groups
ITG12_03280	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
ITG12_03290	COG3064	Membrane
ITG12_03310	COG3300	MHYT domain
ITG12_03310	COG5001	Diguanylate cyclase
ITG12_03315	COG3437	response regulator, receiver
ITG12_03315	COG2205	protein histidine kinase activity
ITG12_03315	COG3850	Histidine kinase
ITG12_03315	COG4999	Histidine kinase
ITG12_03335	COG0110	maltose O-acetyltransferase activity
ITG12_03360	COG1846	Transcriptional regulator
ITG12_03375	COG2202	Pas domain
ITG12_03375	COG2199	diguanylate cyclase activity
ITG12_03375	COG2200	EAL domain
ITG12_03390	COG3247	response to pH
ITG12_03395	COG0668	transmembrane transport
ITG12_03410	COG2885	chlorophyll binding
ITG12_03410	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
ITG12_03415	COG5492	domain, Protein
ITG12_03415	COG4932	domain protein
ITG12_03420	COG1404	Belongs to the peptidase S8 family
ITG12_03435	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
ITG12_03515	COG0519	Catalyzes the synthesis of GMP from XMP
ITG12_03525	COG0297	glycogen (starch) synthase activity
ITG12_03535	COG0668	transmembrane transport
ITG12_03555	COG1196	nuclear chromosome segregation
ITG12_03565	COG1401	restriction endodeoxyribonuclease activity
ITG12_03575	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ITG12_03595	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
ITG12_03665	COG0625	glutathione transferase activity
ITG12_03675	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
ITG12_03690	COG2195	Cleaves the N-terminal amino acid of tripeptides
ITG12_03720	COG0813	purine-nucleoside phosphorylase activity
ITG12_03735	COG1451	nucleotide metabolic process
ITG12_03760	COG2165	general secretion pathway protein
ITG12_03765	COG0583	DNA-binding transcription factor activity
ITG12_03795	COG4139	cobalamin transport
ITG12_03820	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
ITG12_03830	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ITG12_03835	COG0702	epimerase
ITG12_03840	COG1823	symporter activity
ITG12_03850	COG2925	Exonuclease
ITG12_03860	COG1346	cytolysis
ITG12_03900	COG0072	phenylalanine-tRNA ligase activity
ITG12_03900	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ITG12_03945	COG0251	oxidation-reduction process
ITG12_03960	COG0291	Belongs to the bacterial ribosomal protein bL35 family
ITG12_03980	COG2188	Transcriptional regulator
ITG12_03990	COG0010	Belongs to the arginase family
ITG12_04000	COG2986	histidine ammonia-lyase
ITG12_04045	COG0247	lactate metabolic process
ITG12_04045	COG0277	FAD linked oxidase domain protein
ITG12_04100	COG1643	Atp-dependent helicase
ITG12_04110	COG2949	membrane
ITG12_04115	COG0471	metal ion transport
ITG12_04120	COG3706	GGDEF domain
ITG12_04140	COG0492	ferredoxin-NADP+ reductase activity
ITG12_04145	COG4988	ABC transporter
ITG12_04150	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
ITG12_04160	COG0583	DNA-binding transcription factor activity
ITG12_04165	COG2200	EAL domain
ITG12_04195	COG5001	Diguanylate cyclase
ITG12_04205	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
ITG12_04215	COG4191	Histidine kinase
ITG12_04215	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ITG12_04230	COG3070	regulator of competence-specific genes
ITG12_04240	COG2431	L-lysine efflux transmembrane transporter activity
ITG12_04250	COG0076	glutamate decarboxylase activity
ITG12_04255	COG1737	Transcriptional regulator
ITG12_04265	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
ITG12_04275	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
ITG12_04310	COG0534	Mate efflux family protein
ITG12_04315	COG0702	epimerase
ITG12_04320	COG4667	esterase of the alpha-beta hydrolase superfamily
ITG12_04330	COG2814	Major facilitator Superfamily
ITG12_04335	COG1187	pseudouridine synthase activity
ITG12_04340	COG1061	Type III restriction enzyme res subunit
ITG12_04345	COG3706	GGDEF domain
ITG12_04385	COG0454	-acetyltransferase
ITG12_04400	COG3313	Fe-S protein
ITG12_04410	COG0659	secondary active sulfate transmembrane transporter activity
ITG12_04435	COG0493	'glutamate synthase
ITG12_04445	COG0398	Pfam SNARE associated Golgi protein
ITG12_04450	COG4134	Bacterial extracellular solute-binding protein
ITG12_04455	COG4135	transport system, permease component
ITG12_04460	COG4136	ATPase activity
ITG12_04465	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ITG12_04475	COG3604	Transcriptional regulator
ITG12_04480	COG1151	hydroxylamine reductase activity
ITG12_04485	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ITG12_04495	COG0564	pseudouridine synthase activity
ITG12_04505	COG0733	neurotransmitter:sodium symporter activity
ITG12_04515	COG0626	cystathionine gamma-synthase activity
ITG12_04520	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
ITG12_04525	COG5380	lipid catabolic process
ITG12_04530	COG2818	Glycosylase
ITG12_04540	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ITG12_04560	COG1842	Phage shock protein A
ITG12_04565	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
ITG12_04575	COG4168	peptide transport system, permease
ITG12_04580	COG4171	peptide transport system, permease
ITG12_04590	COG4172	Belongs to the ABC transporter superfamily
ITG12_04600	COG1227	inorganic diphosphatase activity
ITG12_04605	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ITG12_04610	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ITG12_04615	COG1121	(ABC) transporter
ITG12_04630	COG0243	molybdopterin cofactor binding
ITG12_04635	COG3005	denitrification pathway
ITG12_04640	COG4459	periplasmic nitrate reductase
ITG12_04645	COG0390	transport system, permease component
ITG12_04655	COG2116	formate transmembrane transporter activity
ITG12_04680	COG1434	Gram-negative-bacterium-type cell wall biogenesis
ITG12_04685	COG1435	thymidine kinase activity
ITG12_04690	COG0215	cysteine-tRNA ligase activity
ITG12_04695	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ITG12_04700	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ITG12_04705	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
ITG12_04710	COG3012	SEC-C Motif Domain Protein
ITG12_04715	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
ITG12_04715	COG0140	phosphoribosyl-ATP diphosphatase activity
ITG12_04725	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
ITG12_04730	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
ITG12_04735	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
ITG12_04735	COG0131	Imidazoleglycerol-phosphate dehydratase
ITG12_04745	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
ITG12_04755	COG1757	Na H antiporter
ITG12_04765	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ITG12_04785	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
ITG12_04805	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
ITG12_04820	COG0300	oxidoreductase activity
ITG12_04865	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
ITG12_04885	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
ITG12_04895	COG1674	ftsk spoiiie
ITG12_04905	COG0686	Belongs to the AlaDH PNT family
ITG12_04915	COG0583	DNA-binding transcription factor activity
ITG12_04930	COG2801	Transposase and inactivated derivatives
ITG12_04990	COG4934	collagen metabolic process
ITG12_05010	COG3568	Endonuclease Exonuclease Phosphatase
ITG12_05035	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
ITG12_05045	COG0800	Aldolase
ITG12_05050	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ITG12_05055	COG1917	Cupin 2, conserved barrel domain protein
ITG12_05080	COG2186	Transcriptional regulator
ITG12_05085	COG1028	Short-chain dehydrogenase reductase Sdr
ITG12_05090	COG2186	Transcriptional regulator
ITG12_05095	COG0517	IMP dehydrogenase activity
ITG12_05100	COG2176	DNA-directed DNA polymerase activity
ITG12_05110	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
ITG12_05125	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ITG12_05155	COG1288	antiporter activity
ITG12_05165	COG2186	Transcriptional regulator
ITG12_05175	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ITG12_05180	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ITG12_05215	COG4608	Belongs to the ABC transporter superfamily
ITG12_05220	COG0444	Belongs to the ABC transporter superfamily
ITG12_05225	COG0534	Mate efflux family protein
ITG12_05240	COG2824	Alkylphosphonate utilization operon protein PhnA
ITG12_05245	COG2723	6-phospho-beta-galactosidase activity
ITG12_05250	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ITG12_05250	COG1263	PTS System
ITG12_05255	COG3119	arylsulfatase activity
ITG12_05275	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ITG12_05295	COG0457	Tetratricopeptide repeat
ITG12_05365	COG4790	Type iii secretion
ITG12_05370	COG4794	Type iii secretion
ITG12_05375	COG4791	protein targeting
ITG12_05380	COG4792	protein secretion
ITG12_05395	COG3177	Filamentation induced by cAMP protein fic
ITG12_05415	COG4669	(LipO)protein
ITG12_05545	COG0784	Response regulator, receiver
ITG12_05545	COG5002	protein histidine kinase activity
ITG12_05555	COG0754	glutathionylspermidine amidase activity
ITG12_05565	COG3766	membrane
ITG12_05580	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
ITG12_05585	COG2885	chlorophyll binding
ITG12_05590	COG0823	Involved in the tonB-independent uptake of proteins
ITG12_05605	COG0811	peptide transport
ITG12_05610	COG0824	Thioesterase
ITG12_05620	COG4890	Cyd operon protein YbgT
ITG12_05625	COG1294	oxidase, subunit
ITG12_05630	COG1271	oxidase subunit
ITG12_05640	COG0632	four-way junction helicase activity
ITG12_05645	COG0840	transmembrane signaling receptor activity
ITG12_05655	COG0217	transcriptional regulatory protein
ITG12_05665	COG1801	Protein of unknown function DUF72
ITG12_05680	COG4067	protein conserved in archaea
ITG12_05680	COG0189	ligase activity
ITG12_05705	COG0318	PFAM AMP-dependent synthetase and ligase
ITG12_05720	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
ITG12_05725	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
ITG12_05730	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
ITG12_05735	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ITG12_05740	COG1434	Gram-negative-bacterium-type cell wall biogenesis
ITG12_05745	COG0745	RESPONSE REGULATOR receiver
ITG12_05760	COG3070	regulator of competence-specific genes
ITG12_05780	COG0297	glycogen (starch) synthase activity
ITG12_05785	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
ITG12_05790	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ITG12_05820	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
ITG12_05825	COG0542	response to heat
ITG12_05835	COG1278	Cold shock
ITG12_05845	COG1187	pseudouridine synthase activity
ITG12_05850	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
ITG12_05860	COG1199	ATP-dependent helicase activity
ITG12_05865	COG0730	response to heat
ITG12_05870	COG3923	Primosomal replication protein n
ITG12_05880	COG0708	Exodeoxyribonuclease III
ITG12_05890	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ITG12_05930	COG1882	Formate acetyltransferase
ITG12_05940	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
ITG12_05955	COG2766	serine protein kinase
ITG12_05960	COG2718	Belongs to the UPF0229 family
ITG12_05965	COG2719	SpoVR family
ITG12_05985	COG1132	(ABC) transporter
ITG12_05990	COG0658	competence protein
ITG12_05990	COG2333	competence protein COMEC
ITG12_06000	COG4591	ABC-type transport system involved in lipoprotein release permease component
ITG12_06005	COG1136	(ABC) transporter
ITG12_06010	COG4591	ABC-type transport system involved in lipoprotein release permease component
ITG12_06020	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
ITG12_06035	COG1252	NADH dehydrogenase
ITG12_06065	COG0537	adenosine 5'-monophosphoramidase activity
ITG12_06095	COG0516	GMP reductase activity
ITG12_06095	COG0517	IMP dehydrogenase activity
ITG12_06100	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
ITG12_06105	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
ITG12_06110	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ITG12_06115	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
ITG12_06125	COG2199	diguanylate cyclase activity
ITG12_06140	COG3126	Type III secretion system lipoprotein chaperone (YscW)
ITG12_06145	COG1946	Acyl-CoA thioesterase
ITG12_06155	COG1522	sequence-specific DNA binding
ITG12_06180	COG2963	transposase activity
ITG12_06185	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ITG12_06190	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ITG12_06240	COG2855	membrane
ITG12_06250	COG0583	DNA-binding transcription factor activity
ITG12_06255	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ITG12_06255	COG1263	PTS System
ITG12_06255	COG2190	(PTS) system
ITG12_06270	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
ITG12_06275	COG0596	Alpha beta hydrolase
ITG12_06285	COG1169	isochorismate synthase
ITG12_06290	COG0436	Aminotransferase
ITG12_06295	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
ITG12_06315	COG1555	photosystem II stabilization
ITG12_06320	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ITG12_06325	COG0776	regulation of translation
ITG12_06330	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
ITG12_06360	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
ITG12_06365	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
ITG12_06370	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
ITG12_06390	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ITG12_06395	COG0569	domain protein
ITG12_06400	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
ITG12_06405	COG0513	Belongs to the DEAD box helicase family
ITG12_06410	COG1253	flavin adenine dinucleotide binding
ITG12_06415	COG4771	TonB-dependent receptor
ITG12_06430	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ITG12_06430	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ITG12_06435	COG3433	isochorismatase activity
ITG12_06435	COG1535	isochorismatase
ITG12_06440	COG1021	2,3-dihydroxybenzoate-AMP ligase
ITG12_06445	COG1169	isochorismate synthase
ITG12_06455	COG1028	Short-chain dehydrogenase reductase Sdr
ITG12_06465	COG2391	methyltransferase activity
ITG12_06570	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ITG12_06575	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ITG12_06585	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ITG12_06595	COG1216	Glycosyl transferase, family 2
ITG12_06600	COG2986	histidine ammonia-lyase
ITG12_06635	COG1028	Short-chain dehydrogenase reductase Sdr
ITG12_06655	COG2852	Protein conserved in bacteria
ITG12_06660	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ITG12_06670	COG2951	lytic endotransglycosylase activity
ITG12_06685	COG2894	cell division
ITG12_06690	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
ITG12_06695	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
ITG12_06700	COG0318	PFAM AMP-dependent synthetase and ligase
ITG12_06705	COG2267	carboxylic ester hydrolase activity
ITG12_06710	COG3065	identical protein binding
ITG12_06720	COG1214	PFAM Peptidase M22, glycoprotease
ITG12_06725	COG1199	ATP-dependent helicase activity
ITG12_06730	COG0788	formyltetrahydrofolate deformylase activity
ITG12_06735	COG3102	Protein conserved in bacteria
ITG12_06765	COG1918	ferrous iron import across plasma membrane
ITG12_06770	COG4977	sequence-specific DNA binding
ITG12_06775	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
ITG12_06780	COG1121	(ABC) transporter
ITG12_06785	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ITG12_06790	COG2801	Transposase and inactivated derivatives
ITG12_06800	COG2963	transposase activity
ITG12_06815	COG0508	dehydrogenase complex catalyzes the overall conversion of
ITG12_06820	COG0567	Dehydrogenase, E1 component
ITG12_06830	COG1053	succinate dehydrogenase
ITG12_06835	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
ITG12_06850	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
ITG12_06860	COG0033	Phosphoglucomutase
ITG12_06865	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
ITG12_06870	COG0596	Alpha beta hydrolase
ITG12_06890	COG0735	belongs to the Fur family
ITG12_06895	COG2165	general secretion pathway protein
ITG12_06905	COG1263	PTS System
ITG12_06905	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ITG12_06905	COG2190	(PTS) system
ITG12_06910	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
ITG12_06915	COG1846	Transcriptional regulator
ITG12_06915	COG1940	carbohydrate kinase activity
ITG12_06920	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ITG12_06920	COG4651	solute:proton antiporter activity
ITG12_06925	COG0367	asparagine synthase
ITG12_06930	COG0250	Participates in transcription elongation, termination and antitermination
ITG12_06935	COG3104	oligopeptide transport
ITG12_06940	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
ITG12_06955	COG3710	Transcriptional regulator
ITG12_06975	COG0622	Phosphoesterase
ITG12_07000	COG1090	epimerase
ITG12_07005	COG0300	oxidoreductase activity
ITG12_07010	COG3118	belongs to the thioredoxin family
ITG12_07015	COG0457	Tetratricopeptide repeat
ITG12_07015	COG3118	belongs to the thioredoxin family
ITG12_07020	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
ITG12_07025	COG1215	transferase activity, transferring glycosyl groups
ITG12_07030	COG1215	transferase activity, transferring glycosyl groups
ITG12_07055	COG2194	sulfuric ester hydrolase activity
ITG12_07060	COG0330	HflC and HflK could
ITG12_07090	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
ITG12_07095	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ITG12_07100	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ITG12_07105	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ITG12_07110	COG2190	(PTS) system
ITG12_07115	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ITG12_07130	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ITG12_07135	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ITG12_07150	COG1705	Flagellar rod assembly protein muramidase FlgJ
ITG12_07150	COG3951	Flagellar rod assembly protein muramidase FlgJ
ITG12_07155	COG1706	bacterial-type flagellum-dependent cell motility
ITG12_07160	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
ITG12_07170	COG4787	bacterial-type flagellum-dependent cell motility
ITG12_07175	COG1749	Flagellar hook protein flgE
ITG12_07185	COG1558	bacterial-type flagellum-dependent cell motility
ITG12_07190	COG1815	bacterial-type flagellum-dependent cell motility
ITG12_07195	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
ITG12_07200	COG0835	chemotaxis
ITG12_07200	COG0784	Response regulator, receiver
ITG12_07255	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
ITG12_07265	COG2608	mercury ion transmembrane transporter activity
ITG12_07265	COG2217	Heavy metal translocating P-type atpase
ITG12_07310	COG1187	pseudouridine synthase activity
ITG12_07315	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
ITG12_07330	COG2912	Transglutaminase-like superfamily
ITG12_07335	COG3094	Invasion gene expression up-regulator, SirB
ITG12_07340	COG2890	protein-(glutamine-N5) methyltransferase activity
ITG12_07365	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ITG12_07480	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ITG12_07490	COG1702	phosphate starvation-inducible protein PhoH
ITG12_07500	COG4535	Mg2 and Co2 transporter CorC
ITG12_07505	COG0815	Transfers the fatty acyl group on membrane lipoproteins
ITG12_07510	COG2888	peptidyl-tyrosine sulfation
ITG12_07515	COG0495	leucyl-tRNA aminoacylation
ITG12_07520	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
ITG12_07525	COG1466	dna polymerase III delta subunit
ITG12_07530	COG0799	negative regulation of ribosome biogenesis
ITG12_07535	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
ITG12_07540	COG0768	penicillin binding
ITG12_07545	COG0772	Belongs to the SEDS family
ITG12_07550	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
ITG12_07555	COG1686	Belongs to the peptidase S11 family
ITG12_07575	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
ITG12_07580	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ITG12_07595	COG0366	Alpha amylase catalytic
ITG12_07600	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ITG12_07600	COG1263	PTS System
ITG12_07610	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
ITG12_07615	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
ITG12_07620	COG2011	ABC-type metal ion transport system permease component
ITG12_07625	COG1464	Belongs to the NlpA lipoprotein family
ITG12_07635	COG0737	Belongs to the 5'-nucleotidase family
ITG12_07640	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
ITG12_07665	COG1611	Belongs to the LOG family
ITG12_07680	COG2363	Small membrane protein
ITG12_07690	COG0583	DNA-binding transcription factor activity
ITG12_07705	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
ITG12_07715	COG0142	geranyltranstransferase activity
ITG12_07725	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
ITG12_07730	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
ITG12_07755	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ITG12_07755	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ITG12_07760	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
ITG12_07765	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
ITG12_07780	COG1073	alpha beta
ITG12_07790	COG2252	PERMEase
ITG12_07795	COG2195	Cleaves the N-terminal amino acid of tripeptides
ITG12_07825	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ITG12_07825	COG0047	phosphoribosylformylglycinamidine synthase activity
ITG12_07840	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
ITG12_07880	COG1301	dicarboxylic acid transport
ITG12_07900	COG0497	DNA recombination
ITG12_07910	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ITG12_07920	COG2914	Belongs to the UPF0125 (RnfH) family
ITG12_07925	COG2867	negative regulation of translational initiation
ITG12_07940	COG0583	DNA-binding transcription factor activity
ITG12_07945	COG1289	transmembrane transporter activity
ITG12_07965	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ITG12_07970	COG2873	o-acetylhomoserine
ITG12_07975	COG0668	transmembrane transport
ITG12_07990	COG0583	DNA-binding transcription factor activity
ITG12_08000	COG1115	amino acid carrier protein
ITG12_08005	COG1584	GPR1 FUN34 yaaH family protein
ITG12_08015	COG1757	Na H antiporter
ITG12_08025	COG0516	GMP reductase activity
ITG12_08025	COG0517	IMP dehydrogenase activity
ITG12_08040	COG2199	diguanylate cyclase activity
ITG12_08040	COG2203	Gaf domain
ITG12_08055	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ITG12_08060	COG2976	Protein conserved in bacteria
ITG12_08095	COG2975	iron-sulfur cluster assembly
ITG12_08100	COG0633	Ferredoxin
ITG12_08115	COG0316	Belongs to the HesB IscA family
ITG12_08120	COG0822	iron-sulfur transferase activity
ITG12_08135	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
ITG12_08140	COG0483	inositol monophosphate 1-phosphatase activity
ITG12_08155	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ITG12_08160	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ITG12_08165	COG1862	Preprotein translocase
ITG12_08170	COG0343	queuine tRNA-ribosyltransferase activity
ITG12_08175	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
ITG12_08190	COG0517	IMP dehydrogenase activity
ITG12_08200	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
ITG12_08205	COG0583	DNA-binding transcription factor activity
ITG12_08210	COG0450	alkyl hydroperoxide reductase
ITG12_08240	COG0704	Plays a role in the regulation of phosphate uptake
ITG12_08245	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ITG12_08250	COG0581	inorganic phosphate transmembrane transporter activity
ITG12_08255	COG0573	inorganic phosphate transmembrane transporter activity
ITG12_08260	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
ITG12_08265	COG0248	Ppx GppA phosphatase
ITG12_08275	COG5002	protein histidine kinase activity
ITG12_08280	COG0745	RESPONSE REGULATOR receiver
ITG12_08290	COG0826	peptidase U32
ITG12_08295	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
ITG12_08305	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
ITG12_08350	COG0542	response to heat
ITG12_08355	COG1496	oxidoreductase activity
ITG12_08360	COG0564	pseudouridine synthase activity
ITG12_08365	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ITG12_08370	COG0741	lytic transglycosylase activity
ITG12_08375	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
ITG12_08380	COG0077	Prephenate dehydratase
ITG12_08380	COG1605	Chorismate mutase
ITG12_08385	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
ITG12_08400	COG0488	(ABC) transporter
ITG12_08410	COG0739	heme binding
ITG12_08415	COG0287	Prephenate dehydrogenase
ITG12_08415	COG1605	Chorismate mutase
ITG12_08420	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ITG12_08430	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
ITG12_08450	COG1966	Carbon starvation protein
ITG12_08455	COG3275	phosphorelay sensor kinase activity
ITG12_08460	COG3279	Response regulator of the LytR AlgR family
ITG12_08465	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
ITG12_08470	COG1047	Peptidyl-prolyl cis-trans
ITG12_08485	COG0196	riboflavin kinase activity
ITG12_08490	COG0728	peptidoglycan biosynthetic process
ITG12_08495	COG0268	Binds directly to 16S ribosomal RNA
ITG12_08500	COG0640	Transcriptional regulator
ITG12_08505	COG0583	DNA-binding transcription factor activity
ITG12_08510	COG1283	sodium-dependent phosphate transmembrane transporter activity
ITG12_08525	COG0730	response to heat
ITG12_08530	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
ITG12_08550	COG0667	Aldo Keto reductase
ITG12_08575	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
ITG12_08580	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ITG12_08585	COG4974	Belongs to the 'phage' integrase family
ITG12_08590	COG0716	FMN binding
ITG12_08600	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
ITG12_08605	COG0513	Belongs to the DEAD box helicase family
ITG12_08615	COG3022	response to hydroperoxide
ITG12_08620	COG1115	amino acid carrier protein
ITG12_08650	COG0431	NADPH-dependent FMN reductase
ITG12_08660	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
ITG12_08665	COG0083	homoserine kinase activity
ITG12_08680	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
ITG12_08690	COG0745	RESPONSE REGULATOR receiver
ITG12_08700	COG0784	Response regulator, receiver
ITG12_08700	COG2198	Histidine kinase
ITG12_08700	COG5002	protein histidine kinase activity
ITG12_08705	COG5001	Diguanylate cyclase
ITG12_08705	COG4251	negative regulation of phosphorylation
ITG12_08705	COG3706	GGDEF domain
ITG12_08705	COG2203	Gaf domain
ITG12_08710	COG1242	4 iron, 4 sulfur cluster binding
ITG12_08715	COG0069	glutamate synthase activity
ITG12_08715	COG0067	glutamate synthase
ITG12_08715	COG0070	glutamate synthase
ITG12_08725	COG0069	glutamate synthase activity
ITG12_08725	COG0070	glutamate synthase
ITG12_08725	COG0067	glutamate synthase
ITG12_08730	COG0493	'glutamate synthase
ITG12_08755	COG2860	membrane
ITG12_08760	COG0583	DNA-binding transcription factor activity
ITG12_08765	COG0730	response to heat
ITG12_08775	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
ITG12_08780	COG0505	Belongs to the CarA family
ITG12_08790	COG0494	nUDIX hydrolase
ITG12_08805	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
ITG12_08810	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
ITG12_08815	COG0849	cell division
ITG12_08820	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
ITG12_08835	COG0772	Belongs to the SEDS family
ITG12_08850	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
ITG12_08855	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
ITG12_08860	COG0768	penicillin binding
ITG12_08865	COG3116	cell division
ITG12_08880	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
ITG12_08895	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
ITG12_08905	COG2969	positive regulation of protein catabolic process
ITG12_08910	COG0625	glutathione transferase activity
ITG12_08915	COG2857	Cytochrome c1
ITG12_08920	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
ITG12_08925	COG0723	plastoquinol--plastocyanin reductase activity
ITG12_08930	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
ITG12_08940	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
ITG12_08945	COG3105	Protein conserved in bacteria
ITG12_08955	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ITG12_08970	COG3150	esterase
ITG12_08980	COG3151	Protein conserved in bacteria
ITG12_08985	COG0494	nUDIX hydrolase
ITG12_08990	COG1538	Outer membrane efflux protein
ITG12_09000	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
ITG12_09010	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ITG12_09015	COG3025	triphosphatase activity
ITG12_09020	COG1392	Phosphate transport regulator
ITG12_09025	COG0306	phosphate transporter
ITG12_09030	COG4991	sh3 domain protein
ITG12_09035	COG0405	Gamma-glutamyltransferase
ITG12_09045	COG3267	Type II secretory pathway component ExeA
ITG12_09045	COG3409	Peptidoglycan-binding domain 1 protein
ITG12_09060	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
ITG12_09065	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
ITG12_09075	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ITG12_09080	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
ITG12_09085	COG0828	Belongs to the bacterial ribosomal protein bS21 family
ITG12_09090	COG1610	YqeY-like protein
ITG12_09095	COG0358	DNA primase activity
ITG12_09125	COG2801	Transposase and inactivated derivatives
ITG12_09145	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
ITG12_09145	COG2213	PTS system mannitol-specific
ITG12_09155	COG3722	fumarate hydratase activity
ITG12_09160	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ITG12_09165	COG5002	protein histidine kinase activity
ITG12_09185	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ITG12_09190	COG1349	DNA-binding transcription factor activity
ITG12_09195	COG0469	pyruvate kinase activity
ITG12_09205	COG3706	GGDEF domain
ITG12_09210	COG0440	acetolactate synthase activity
ITG12_09215	COG0028	Belongs to the TPP enzyme family
ITG12_09220	COG1022	Amp-dependent synthetase and ligase
ITG12_09225	COG0583	DNA-binding transcription factor activity
ITG12_09245	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ITG12_09250	COG0473	3-isopropylmalate dehydrogenase activity
ITG12_09270	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
ITG12_09275	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
ITG12_09280	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ITG12_09285	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
ITG12_09295	COG2967	ApaG domain
ITG12_09310	COG3610	response to peptide
ITG12_09315	COG2966	Psort location CytoplasmicMembrane, score
ITG12_09330	COG0261	This protein binds to 23S rRNA in the presence of protein L20
ITG12_09335	COG0142	geranyltranstransferase activity
ITG12_09355	COG2358	TRAP transporter, solute receptor (TAXI family
ITG12_09370	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
ITG12_09375	COG1178	ABC-type Fe3 transport system permease component
ITG12_09380	COG4143	(ABC) transporter
ITG12_09385	COG0163	prenyltransferase activity
ITG12_09390	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ITG12_09400	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
ITG12_09415	COG2105	PFAM AIG2 family protein
ITG12_09420	COG2911	Protein conserved in bacteria
ITG12_09425	COG0729	surface antigen
ITG12_09430	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ITG12_09440	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
ITG12_09455	COG1136	(ABC) transporter
ITG12_09475	COG0529	Catalyzes the synthesis of activated sulfate
ITG12_09480	COG3273	potassium ion transport
ITG12_09480	COG0471	metal ion transport
ITG12_09490	COG0175	sulfate reduction
ITG12_09495	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ITG12_09495	COG1648	precorrin-2 dehydrogenase activity
ITG12_09500	COG0737	Belongs to the 5'-nucleotidase family
ITG12_09515	COG0513	Belongs to the DEAD box helicase family
ITG12_09520	COG2153	protein acetylation
ITG12_09535	COG0545	Peptidyl-prolyl cis-trans isomerase
ITG12_09545	COG0203	ribosomal protein L17
ITG12_09550	COG0202	RNA polymerase activity
ITG12_09560	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
ITG12_09565	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
ITG12_09570	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ITG12_09575	COG0201	protein transport
ITG12_09580	COG0200	Binds to the 23S rRNA
ITG12_09585	COG1841	ribosomal large subunit assembly
ITG12_09625	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
ITG12_09655	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
ITG12_09670	COG0088	Forms part of the polypeptide exit tunnel
ITG12_09690	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
ITG12_09695	COG1609	Transcriptional regulator
ITG12_09715	COG1575	Belongs to the MenA family. Type 1 subfamily
ITG12_09720	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
ITG12_09725	COG3074	FtsZ-dependent cytokinesis
ITG12_09730	COG1494	fructose-1,6-bisphosphatase
ITG12_09760	COG0149	triose-phosphate isomerase activity
ITG12_09765	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
ITG12_09785	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
ITG12_09815	COG0438	transferase activity, transferring glycosyl groups
ITG12_09850	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ITG12_09855	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ITG12_09860	COG1560	Kdo2-lipid A biosynthetic process
ITG12_09870	COG1519	Transferase
ITG12_09875	COG1083	cytidylyl-transferase
ITG12_09880	COG0483	inositol monophosphate 1-phosphatase activity
ITG12_09885	COG2089	acid synthase
ITG12_09900	COG2089	acid synthase
ITG12_09910	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
ITG12_09910	COG1181	Belongs to the D-alanine--D-alanine ligase family
ITG12_09915	COG0436	Aminotransferase
ITG12_09925	COG1083	cytidylyl-transferase
ITG12_09930	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ITG12_09935	COG1086	Polysaccharide biosynthesis protein
ITG12_09940	COG3642	lipopolysaccharide core region biosynthetic process
ITG12_09945	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
ITG12_09950	COG0859	PFAM glycosyl transferase family 9
ITG12_09955	COG0463	Glycosyl transferase, family 2
ITG12_09960	COG0438	transferase activity, transferring glycosyl groups
ITG12_09990	COG0227	Belongs to the bacterial ribosomal protein bL28 family
ITG12_10000	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ITG12_10010	COG1560	Kdo2-lipid A biosynthetic process
ITG12_10015	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
ITG12_10020	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
ITG12_10025	COG1561	YicC-like family, N-terminal region
ITG12_10030	COG3710	Transcriptional regulator
ITG12_10055	COG4608	Belongs to the ABC transporter superfamily
ITG12_10060	COG0444	Belongs to the ABC transporter superfamily
ITG12_10065	COG0747	negative chemotaxis
ITG12_10070	COG4239	(ABC) transporter, permease
ITG12_10075	COG4174	ABC transporter (Permease)
ITG12_10080	COG4206	TonB-dependent receptor
ITG12_10095	COG0811	peptide transport
ITG12_10100	COG0848	biopolymer transport protein
ITG12_10115	COG0194	GDP metabolic process
ITG12_10120	COG1758	RNA polymerase activity
ITG12_10125	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ITG12_10130	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ITG12_10135	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
ITG12_10145	COG2233	PERMEase
ITG12_10160	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ITG12_10170	COG2183	response to ionizing radiation
ITG12_10185	COG1040	competence protein
ITG12_10195	COG0494	nUDIX hydrolase
ITG12_10200	COG1218	3'(2'),5'-bisphosphate nucleotidase
ITG12_10210	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
ITG12_10215	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
ITG12_10220	COG3156	type II secretion system protein K
ITG12_10225	COG4795	General secretion pathway protein
ITG12_10230	COG2165	general secretion pathway protein
ITG12_10235	COG2165	general secretion pathway protein
ITG12_10240	COG2165	general secretion pathway protein
ITG12_10245	COG1459	type II secretion system
ITG12_10250	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ITG12_10260	COG3031	protein transport across the cell outer membrane
ITG12_10265	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
ITG12_10285	COG0456	acetyltransferase
ITG12_10290	COG1490	D-aminoacyl-tRNA deacylase activity
ITG12_10310	COG1217	gtp-binding protein TYPA
ITG12_10315	COG0174	glutamine synthetase
ITG12_10325	COG3852	Histidine kinase
ITG12_10330	COG2204	response regulator
ITG12_10335	COG5001	Diguanylate cyclase
ITG12_10340	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
ITG12_10370	COG0218	Necessary for normal cell division and for the maintenance of normal septation
ITG12_10375	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ITG12_10375	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ITG12_10390	COG0084	hydrolase, TatD family'
ITG12_10395	COG0805	protein transport
ITG12_10400	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ITG12_10415	COG3165	ubiquinone biosynthetic process from chorismate
ITG12_10425	COG1322	Protein conserved in bacteria
ITG12_10450	COG2081	HI0933 family
ITG12_10460	COG1528	Iron-storage protein
ITG12_10465	COG0589	response to stress
ITG12_10485	COG5002	protein histidine kinase activity
ITG12_10485	COG5001	Diguanylate cyclase
ITG12_10490	COG1522	sequence-specific DNA binding
ITG12_10500	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
ITG12_10510	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ITG12_10520	COG0800	Aldolase
ITG12_10525	COG2610	gluconate transmembrane transporter activity
ITG12_10530	COG3265	gluconokinase activity
ITG12_10535	COG0129	dihydroxy-acid dehydratase activity
ITG12_10545	COG2076	Multidrug Resistance protein
ITG12_10550	COG0583	DNA-binding transcription factor activity
ITG12_10555	COG1609	Transcriptional regulator
ITG12_10590	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ITG12_10595	COG0601	transmembrane transport
ITG12_10605	COG4172	Belongs to the ABC transporter superfamily
ITG12_10610	COG0546	phosphoglycolate phosphatase activity
ITG12_10650	COG1309	transcriptional regulator
ITG12_10655	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ITG12_10660	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ITG12_10665	COG2960	long-chain fatty acid transporting porin activity
ITG12_10675	COG0583	DNA-binding transcription factor activity
ITG12_10725	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ITG12_10730	COG1739	Uncharacterized protein family UPF0029
ITG12_10740	COG0183	Belongs to the thiolase family
ITG12_10745	COG0604	alcohol dehydrogenase
ITG12_10760	COG0425	Belongs to the sulfur carrier protein TusA family
ITG12_10770	COG2119	membrane
ITG12_10780	COG0751	glycine-tRNA ligase activity
ITG12_10785	COG0366	Alpha amylase catalytic
ITG12_10850	COG4964	Belongs to the GSP D family
ITG12_10870	COG3977	Valine--pyruvate aminotransferase
ITG12_10875	COG0071	Belongs to the small heat shock protein (HSP20) family
ITG12_10880	COG0187	DNA topoisomerase II activity
ITG12_10890	COG0592	DNA-directed DNA polymerase activity
ITG12_10910	COG1126	abc transporter atp-binding protein
ITG12_10940	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
ITG12_10945	COG0445	tRNA wobble uridine modification
ITG12_10950	COG0357	Ribosomal RNA small subunit methyltransferase G
ITG12_10955	COG1192	Involved in chromosome partitioning
ITG12_10960	COG1475	DNA binding
ITG12_10965	COG3312	ion transport
ITG12_10995	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
ITG12_11005	COG0355	proton-transporting ATP synthase activity, rotational mechanism
ITG12_11015	COG0765	amino acid transport
ITG12_11025	COG2814	Major facilitator Superfamily
ITG12_11030	COG0583	DNA-binding transcription factor activity
ITG12_11035	COG3706	GGDEF domain
ITG12_11050	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ITG12_11055	COG3978	acetolactate synthase activity
ITG12_11065	COG0606	chelatase, subunit chli
ITG12_11075	COG0204	Acyl-transferase
ITG12_11080	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ITG12_11085	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
ITG12_11095	COG3084	Protein conserved in bacteria
ITG12_11105	COG4326	sporulation control protein
ITG12_11110	COG1272	protein, Hemolysin III
ITG12_11120	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ITG12_11125	COG0569	domain protein
ITG12_11130	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
ITG12_11130	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ITG12_11150	COG0758	DNA mediated transformation
ITG12_11160	COG0551	DNA topoisomerase type I activity
ITG12_11170	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
ITG12_11175	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
ITG12_11200	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
ITG12_11240	COG2132	Multicopper oxidase
ITG12_11260	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ITG12_11265	COG2104	thiamine diphosphate biosynthetic process
ITG12_11280	COG0006	proline dipeptidase activity
ITG12_11280	COG0006	proline dipeptidase activity
ITG12_11290	COG2814	Major facilitator Superfamily
ITG12_11310	COG3220	belongs to the UPF0276 family
ITG12_11320	COG0210	DNA helicase
ITG12_11325	COG0405	Gamma-glutamyltransferase
ITG12_11330	COG1280	lysine exporter protein (LysE YggA)
ITG12_11340	COG2962	Rard protein
ITG12_11345	COG0514	ATP-dependent DNA helicase (RecQ)
ITG12_11355	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
ITG12_11375	COG3118	belongs to the thioredoxin family
ITG12_11390	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
ITG12_11395	COG0633	Ferredoxin
ITG12_11435	COG3071	HemY protein
ITG12_11440	COG2959	enzyme of heme biosynthesis
ITG12_11445	COG1587	Uroporphyrinogen-III synthase
ITG12_11455	COG3072	Adenylate cyclase
ITG12_11470	COG0019	diaminopimelate decarboxylase activity
ITG12_11490	COG1011	Hydrolase
ITG12_11495	COG3287	FIST C domain
ITG12_11495	COG2199	diguanylate cyclase activity
ITG12_11495	COG2200	EAL domain
ITG12_11500	COG3148	PFAM DTW domain containing protein
ITG12_11515	COG0561	phosphatase activity
ITG12_11520	COG2267	carboxylic ester hydrolase activity
ITG12_11525	COG1280	lysine exporter protein (LysE YggA)
ITG12_11530	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
ITG12_11535	COG0640	Transcriptional regulator
ITG12_11540	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ITG12_11585	COG2095	MarC family integral membrane protein
ITG12_11595	COG0742	ribosomal rna small subunit methyltransferase
ITG12_11600	COG0552	protein localization to endoplasmic reticulum
ITG12_11605	COG2884	Cell division ATP-binding protein ftsE
ITG12_11610	COG2177	Part of the ABC transporter FtsEX involved in
ITG12_11630	COG1580	Controls the rotational direction of flagella during chemotaxis
ITG12_11635	COG3161	chorismate lyase activity
ITG12_11645	COG2937	Belongs to the GPAT DAPAT family
ITG12_11660	COG0534	Mate efflux family protein
ITG12_11665	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ITG12_11670	COG1309	transcriptional regulator
ITG12_11730	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ITG12_11740	COG0812	UDP-N-acetylmuramate dehydrogenase activity
ITG12_11780	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ITG12_11785	COG0250	Participates in transcription elongation, termination and antitermination
ITG12_11790	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
ITG12_11795	COG0081	regulation of translation
ITG12_11800	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
ITG12_11820	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
ITG12_11825	COG2816	NAD+ diphosphatase activity
ITG12_11835	COG1573	uracil-dna glycosylase
ITG12_11845	COG3068	Protein conserved in bacteria
ITG12_11850	COG1253	flavin adenine dinucleotide binding
ITG12_11865	COG0151	Belongs to the GarS family
ITG12_11870	COG0138	bifunctional purine biosynthesis protein purh
ITG12_11880	COG0789	Transcriptional regulator
ITG12_11885	COG3710	Transcriptional regulator
ITG12_11895	COG0531	amino acid
ITG12_11900	COG1982	Orn Lys Arg decarboxylase major
ITG12_11980	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
ITG12_11985	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ITG12_11995	COG0439	Biotin carboxylase
ITG12_12000	COG0511	ligase activity, forming carbon-carbon bonds
ITG12_12005	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
ITG12_12010	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ITG12_12025	COG2814	Major facilitator Superfamily
ITG12_12030	COG2205	protein histidine kinase activity
ITG12_12030	COG2198	Histidine kinase
ITG12_12030	COG0784	Response regulator, receiver
ITG12_12050	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ITG12_12060	COG2095	MarC family integral membrane protein
ITG12_12070	COG4232	protein-disulfide reductase activity
ITG12_12075	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
ITG12_12080	COG1027	Aspartate ammonia-lyase
ITG12_12085	COG3030	protein affecting phage T7 exclusion by the F plasmid
ITG12_12090	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
ITG12_12100	COG2205	protein histidine kinase activity
ITG12_12105	COG0745	RESPONSE REGULATOR receiver
ITG12_12110	COG3678	ATP-independent chaperone mediated protein folding
ITG12_12115	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
ITG12_12125	COG0534	Mate efflux family protein
ITG12_12135	COG0459	protein refolding
ITG12_12145	COG1285	pathogenesis
ITG12_12150	COG1509	lysine 2,3-aminomutase activity
ITG12_12175	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ITG12_12180	COG1053	succinate dehydrogenase
ITG12_12205	COG4942	peptidase
ITG12_12210	COG1045	serine acetyltransferase
ITG12_12225	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ITG12_12230	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
ITG12_12240	COG0840	transmembrane signaling receptor activity
ITG12_12245	COG0471	metal ion transport
ITG12_12255	COG1162	GTPase activity
ITG12_12335	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
ITG12_12340	COG0802	atpase or kinase
ITG12_12345	COG0860	N-Acetylmuramoyl-L-alanine amidase
ITG12_12350	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
ITG12_12365	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
ITG12_12370	COG0330	HflC and HflK could
ITG12_12375	COG0330	HflC and HflK could
ITG12_12380	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
ITG12_12385	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
ITG12_12390	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
ITG12_12395	COG1017	nitric oxide dioxygenase activity
ITG12_12395	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ITG12_12405	COG0557	exoribonuclease II activity
ITG12_12410	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ITG12_12415	COG0546	phosphoglycolate phosphatase activity
ITG12_12440	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ITG12_12460	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ITG12_12465	COG3954	Phosphoribulokinase
ITG12_12475	COG0429	hydrolase of the alpha beta-hydrolase fold
ITG12_12485	COG0488	(ABC) transporter
ITG12_12490	COG2249	NAD(P)H dehydrogenase (quinone) activity
ITG12_12505	COG1047	Peptidyl-prolyl cis-trans
ITG12_12510	COG1446	asparaginase
ITG12_12525	COG0545	Peptidyl-prolyl cis-trans isomerase
ITG12_12530	COG2964	Protein conserved in bacteria
ITG12_12535	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
ITG12_12540	COG2923	Belongs to the DsrF TusC family
ITG12_12545	COG2168	tRNA wobble position uridine thiolation
ITG12_12560	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ITG12_12570	COG2906	2 iron, 2 sulfur cluster binding
ITG12_12580	COG0281	malic enzyme
ITG12_12590	COG0626	cystathionine gamma-synthase activity
ITG12_12595	COG0460	homoserine dehydrogenase
ITG12_12595	COG0527	aspartate kinase activity
ITG12_12600	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
ITG12_12610	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
ITG12_12620	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
ITG12_12635	COG0165	Argininosuccinate lyase
ITG12_12635	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
ITG12_12645	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ITG12_12650	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
ITG12_12650	COG0678	peroxiredoxin activity
ITG12_12660	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
ITG12_12705	COG0338	D12 class N6 adenine-specific DNA methyltransferase
ITG12_12710	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ITG12_12720	COG2965	DNA replication, synthesis of RNA primer
ITG12_12745	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ITG12_12755	COG0432	Pfam Uncharacterised protein family UPF0047
ITG12_12770	COG0735	belongs to the Fur family
ITG12_12775	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ITG12_12795	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
ITG12_12870	COG1410	methionine synthase
ITG12_12870	COG0646	methionine synthase
ITG12_12875	COG0527	aspartate kinase activity
ITG12_12880	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
ITG12_12890	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ITG12_12905	COG0629	single-stranded DNA binding
ITG12_12915	COG2199	diguanylate cyclase activity
ITG12_12915	COG2200	EAL domain
ITG12_12940	COG3409	Peptidoglycan-binding domain 1 protein
ITG12_12940	COG3267	Type II secretory pathway component ExeA
ITG12_12950	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ITG12_12955	COG1459	type II secretion system
ITG12_12965	COG2165	general secretion pathway protein
ITG12_13000	COG1077	Cell shape determining protein MreB Mrl
ITG12_13005	COG1792	Involved in formation and maintenance of cell shape
ITG12_13010	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
ITG12_13015	COG0424	maF-like protein
ITG12_13025	COG3164	Protein of unknown function
ITG12_13030	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ITG12_13035	COG0312	modulator of DNA gyrase
ITG12_13040	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
ITG12_13055	COG0564	pseudouridine synthase activity
ITG12_13060	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ITG12_13065	COG3028	Belongs to the UPF0307 family
ITG12_13070	COG0312	modulator of DNA gyrase
ITG12_13075	COG2239	Acts as a magnesium transporter
ITG12_13080	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ITG12_13090	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ITG12_13095	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
ITG12_13105	COG1137	ATPase activity
ITG12_13110	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
ITG12_13120	COG0517	IMP dehydrogenase activity
ITG12_13120	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
ITG12_13130	COG1127	ABC transporter
ITG12_13135	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ITG12_13140	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
ITG12_13145	COG2854	intermembrane phospholipid transfer
ITG12_13155	COG5007	Belongs to the BolA IbaG family
ITG12_13165	COG0204	Acyl-transferase
ITG12_13170	COG0251	oxidation-reduction process
ITG12_13210	COG0456	acetyltransferase
ITG12_13220	COG0525	valine-tRNA ligase activity
ITG12_13225	COG2927	DNA polymerase III (CHI subunit)
ITG12_13235	COG0795	lipopolysaccharide-transporting ATPase activity
ITG12_13240	COG0795	lipopolysaccharide-transporting ATPase activity
ITG12_13250	COG1028	Short-chain dehydrogenase reductase Sdr
ITG12_13260	COG0726	polysaccharide deacetylase
ITG12_13265	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ITG12_13275	COG1447	Phosphotransferase system cellobiose-specific component IIA
ITG12_13280	COG1486	melibiose metabolic process
ITG12_13285	COG3394	polysaccharide catabolic process
ITG12_13345	COG1012	belongs to the aldehyde dehydrogenase family
ITG12_13445	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ITG12_13450	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
ITG12_13460	COG1872	DUF167
ITG12_13465	COG0762	integral membrane protein
ITG12_13470	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ITG12_13475	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
ITG12_13490	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
ITG12_13495	COG1678	Uncharacterized ACR, COG1678
ITG12_13500	COG0189	ligase activity
ITG12_13505	COG1385	rRNA (uridine-N3-)-methyltransferase activity
ITG12_13510	COG2356	endonuclease I
ITG12_13530	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
ITG12_13550	COG0191	fructose-bisphosphate aldolase activity
ITG12_13555	COG0668	transmembrane transport
ITG12_13570	COG0583	DNA-binding transcription factor activity
ITG12_13580	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ITG12_13590	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
ITG12_13600	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
ITG12_13605	COG3079	Belongs to the UPF0149 family
ITG12_13610	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ITG12_13615	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ITG12_13635	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
ITG12_13645	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
ITG12_13650	COG1595	DNA-templated transcription, initiation
ITG12_13660	COG3026	antisigma factor binding
ITG12_13670	COG0481	GTPase activity
ITG12_13685	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
ITG12_13690	COG1381	Involved in DNA repair and RecF pathway recombination
ITG12_13695	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
ITG12_13715	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ITG12_13720	COG3956	TIGRFAM MazG family protein
ITG12_13730	COG0148	phosphopyruvate hydratase activity
ITG12_13740	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
ITG12_13770	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ITG12_13780	COG1546	Belongs to the CinA family
ITG12_13785	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
ITG12_13890	COG3630	sodium ion export across plasma membrane
ITG12_13895	COG0511	ligase activity, forming carbon-carbon bonds
ITG12_13895	COG5016	pyruvate
ITG12_13900	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
ITG12_13910	COG1238	metal cluster binding
ITG12_13915	COG0612	Peptidase, M16
ITG12_13935	COG4536	flavin adenine dinucleotide binding
ITG12_13940	COG4137	Cytochrome C assembly protein
ITG12_13945	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ITG12_13950	COG0228	four-way junction DNA binding
ITG12_13970	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
ITG12_13975	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
ITG12_13980	COG0237	dephospho-CoA kinase activity
ITG12_13990	COG1459	type II secretion system
ITG12_13995	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ITG12_14015	COG2186	Transcriptional regulator
ITG12_14020	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
ITG12_14025	COG0508	dehydrogenase complex catalyzes the overall conversion of
ITG12_14030	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ITG12_14045	COG0288	reversible hydration of carbon dioxide
ITG12_14050	COG0659	secondary active sulfate transmembrane transporter activity
ITG12_14055	COG1131	(ABC) transporter
ITG12_14060	COG0842	Transport permease protein
ITG12_14065	COG1560	Kdo2-lipid A biosynthetic process
ITG12_14080	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
ITG12_14090	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ITG12_14105	COG1643	Atp-dependent helicase
ITG12_14110	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ITG12_14115	COG1752	Esterase of the alpha-beta hydrolase superfamily
ITG12_14120	COG1049	propionate catabolic process, 2-methylcitrate cycle
ITG12_14135	COG0004	ammonium transporteR
ITG12_14140	COG1840	ABC-type Fe3 transport system, periplasmic component
ITG12_14150	COG3842	ATPase activity
ITG12_14155	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ITG12_14170	COG2971	BadF BadG BcrA BcrD
ITG12_14180	COG4608	Belongs to the ABC transporter superfamily
ITG12_14185	COG0444	Belongs to the ABC transporter superfamily
ITG12_14190	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ITG12_14200	COG0747	negative chemotaxis
ITG12_14205	COG2205	protein histidine kinase activity
ITG12_14205	COG0784	Response regulator, receiver
ITG12_14215	COG0628	permease
ITG12_14235	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ITG12_14240	COG0739	heme binding
ITG12_14245	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
ITG12_14255	COG2027	D-alanyl-D-alanine carboxypeptidase
ITG12_14260	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
ITG12_14265	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ITG12_14270	COG1534	Rna-binding protein
ITG12_14275	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
ITG12_14280	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ITG12_14285	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
ITG12_14295	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ITG12_14315	COG0195	Participates in both transcription termination and antitermination
ITG12_14335	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
ITG12_14355	COG0534	Mate efflux family protein
ITG12_14360	COG0826	peptidase U32
ITG12_14365	COG0826	peptidase U32
ITG12_14375	COG3154	lipid carrier protein
ITG12_14380	COG3153	acetyltransferase
ITG12_14410	COG0084	hydrolase, TatD family'
ITG12_14415	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ITG12_14420	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
ITG12_14425	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
ITG12_14435	COG0813	purine-nucleoside phosphorylase activity
ITG12_14445	COG0560	Phosphoserine phosphatase
ITG12_14455	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
ITG12_14460	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ITG12_14465	COG0583	DNA-binding transcription factor activity
ITG12_14500	COG1022	Amp-dependent synthetase and ligase
ITG12_14505	COG0741	lytic transglycosylase activity
ITG12_14530	COG4964	Belongs to the GSP D family
ITG12_14590	COG0583	DNA-binding transcription factor activity
ITG12_14595	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
ITG12_14595	COG3408	Glycogen debranching enzyme
ITG12_14605	COG0531	amino acid
ITG12_14610	COG2731	YhcH YjgK YiaL family protein
ITG12_14615	COG3250	beta-galactosidase activity
ITG12_14620	COG1609	Transcriptional regulator
ITG12_14625	COG0768	penicillin binding
ITG12_14630	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
ITG12_14635	COG1085	galactose-1-phosphate uridylyltransferase
ITG12_14645	COG2017	converts alpha-aldose to the beta-anomer
ITG12_14650	COG1609	Transcriptional regulator
ITG12_14655	COG1263	PTS System
ITG12_14655	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ITG12_14665	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ITG12_14690	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
ITG12_14695	COG1349	DNA-binding transcription factor activity
ITG12_14705	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
ITG12_14710	COG2271	Major facilitator Superfamily
ITG12_14715	COG0584	glycerophosphoryl diester phosphodiesterase
ITG12_14730	COG2171	N-acyltransferase activity
ITG12_14745	COG3141	response to X-ray
ITG12_14760	COG2261	transglycosylase associated protein
ITG12_14770	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
ITG12_14775	COG1074	ATP-dependent DNA helicase activity
ITG12_14780	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ITG12_14800	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ITG12_14800	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
ITG12_14810	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
ITG12_14815	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
ITG12_14820	COG2166	iron-sulfur cluster assembly
ITG12_14825	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ITG12_14830	COG0693	protein deglycase activity
ITG12_14835	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
ITG12_14840	COG3248	Nucleoside-binding outer membrane protein
ITG12_14855	COG1595	DNA-templated transcription, initiation
ITG12_14885	COG0271	Belongs to the BolA IbaG family
ITG12_14890	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
ITG12_14910	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
ITG12_14920	COG1477	protein flavinylation
ITG12_14935	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ITG12_14940	COG0514	ATP-dependent DNA helicase (RecQ)
ITG12_14945	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ITG12_14960	COG0733	neurotransmitter:sodium symporter activity
ITG12_14985	COG1720	tRNA m6t6A37 methyltransferase activity
ITG12_15000	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
ITG12_15035	COG3098	single-species biofilm formation
ITG12_15040	COG0564	pseudouridine synthase activity
ITG12_15055	COG0024	Methionine aminopeptidase
ITG12_15080	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
ITG12_15085	COG0575	Belongs to the CDS family
ITG12_15095	COG0750	zinc metalloprotease
ITG12_15105	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
ITG12_15110	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ITG12_15135	COG0587	DNA-directed DNA polymerase activity
ITG12_15155	COG0347	Belongs to the P(II) protein family
ITG12_15170	COG0741	lytic transglycosylase activity
ITG12_15170	COG1388	LysM domain
ITG12_15180	COG2226	methyltransferase
ITG12_15190	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ITG12_15225	COG1960	acyl-CoA dehydrogenase activity
ITG12_15230	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
ITG12_15235	COG0121	glutamine amidotransferase
ITG12_15240	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
ITG12_15245	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
ITG12_15250	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
ITG12_15255	COG2233	PERMEase
ITG12_15275	COG1393	Belongs to the ArsC family
ITG12_15280	COG4783	chaperone-mediated protein folding
ITG12_15300	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ITG12_15345	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ITG12_15375	COG2716	regulation of RNA biosynthetic process
ITG12_15380	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ITG12_15385	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
ITG12_15400	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ITG12_15405	COG1393	Belongs to the ArsC family
ITG12_15430	COG2837	iron assimilation
ITG12_15435	COG2169	Transcriptional regulator
ITG12_15440	COG1486	melibiose metabolic process
ITG12_15445	COG2211	Major facilitator Superfamily
ITG12_15455	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ITG12_15460	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ITG12_15465	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ITG12_15470	COG1334	flagellar protein FlaG
ITG12_15475	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
ITG12_15485	COG1516	flagellar protein fliS
ITG12_15505	COG1677	Flagellar hook-basal body complex protein FliE
ITG12_15515	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ITG12_15570	COG1987	bacterial-type flagellum assembly
ITG12_15575	COG1684	flagellar biosynthetic protein fliR
ITG12_15610	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
ITG12_15615	COG2198	Histidine kinase
ITG12_15615	COG0784	Response regulator, receiver
ITG12_15615	COG0643	Histidine kinase
ITG12_15620	COG2201	protein-glutamate methylesterase activity
ITG12_15625	COG1192	Involved in chromosome partitioning
ITG12_15635	COG0835	chemotaxis
ITG12_15645	COG4133	protoheme IX ABC transporter activity
ITG12_15650	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ITG12_15655	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ITG12_15670	COG1138	Cytochrome C-type biogenesis protein
ITG12_15675	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ITG12_15685	COG3088	subunit of a heme lyase
ITG12_15685	COG4235	cytochrome complex assembly
ITG12_15690	COG2853	Lipoprotein
ITG12_15695	COG2067	long-chain fatty acid transport protein
ITG12_15700	COG2067	long-chain fatty acid transport protein
ITG12_15715	COG0183	Belongs to the thiolase family
ITG12_15735	COG2062	phosphohistidine phosphatase, SixA
ITG12_15745	COG2890	protein-(glutamine-N5) methyltransferase activity
ITG12_15755	COG2860	membrane
ITG12_15760	COG3101	peptidyl-lysine hydroxylation
ITG12_15780	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ITG12_15785	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ITG12_15790	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ITG12_15810	COG0285	dihydrofolate synthase activity
ITG12_15815	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
ITG12_15820	COG1286	toxin biosynthetic process
ITG12_15825	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
ITG12_15830	COG0583	DNA-binding transcription factor activity
ITG12_15835	COG0745	RESPONSE REGULATOR receiver
ITG12_15840	COG2832	Protein of unknown function (DUF454)
ITG12_15860	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
ITG12_15865	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
ITG12_15870	COG0814	amino acid
ITG12_15875	COG0251	oxidation-reduction process
ITG12_15885	COG2964	Protein conserved in bacteria
ITG12_15900	COG2983	Belongs to the UPF0260 family
ITG12_15905	COG2261	transglycosylase associated protein
ITG12_15910	COG2985	domain, Protein
ITG12_15915	COG0076	glutamate decarboxylase activity
ITG12_15920	COG0668	transmembrane transport
ITG12_15930	COG0346	lactoylglutathione lyase activity
ITG12_15940	COG1785	Belongs to the alkaline phosphatase family
ITG12_15960	COG2226	methyltransferase
ITG12_15985	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ITG12_15990	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ITG12_16000	COG3139	Protein of unknown function (DUF1315)
ITG12_16005	COG0252	asparaginase activity
ITG12_16010	COG0616	signal peptide processing
ITG12_16015	COG0446	pyridine nucleotide-disulphide oxidoreductase
ITG12_16015	COG1902	pentaerythritol trinitrate reductase activity
ITG12_16020	COG0778	Nitroreductase
ITG12_16025	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ITG12_16040	COG0123	including yeast histone deacetylase and acetoin utilization protein
ITG12_16045	COG4269	membrane
ITG12_16060	COG3083	sulfuric ester hydrolase activity
ITG12_16085	COG1757	Na H antiporter
ITG12_16090	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ITG12_16095	COG2165	general secretion pathway protein
ITG12_16100	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ITG12_16105	COG2095	MarC family integral membrane protein
ITG12_16110	COG1012	belongs to the aldehyde dehydrogenase family
ITG12_16110	COG1454	alcohol dehydrogenase
ITG12_16130	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
ITG12_16140	COG2056	Na+-H+ antiporter family
ITG12_16150	COG2885	chlorophyll binding
ITG12_16160	COG0346	lactoylglutathione lyase activity
ITG12_16165	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
ITG12_16170	COG4660	Part of a membrane complex involved in electron transport
ITG12_16175	COG4659	FMN binding
ITG12_16180	COG4658	electron transport chain
ITG12_16185	COG4656	Part of a membrane complex involved in electron transport
ITG12_16195	COG4657	Part of a membrane complex involved in electron transport
ITG12_16200	COG1882	Formate acetyltransferase
ITG12_16210	COG0556	nucleotide-excision repair
ITG12_16220	COG2198	Histidine kinase
ITG12_16225	COG0391	Required for morphogenesis under gluconeogenic growth conditions
ITG12_16230	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ITG12_16235	COG0521	Mo-molybdopterin cofactor biosynthetic process
ITG12_16240	COG0315	cyclic pyranopterin monophosphate synthase activity
ITG12_16245	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
ITG12_16250	COG0314	molybdopterin synthase activity
ITG12_16260	COG0601	transmembrane transport
ITG12_16265	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ITG12_16270	COG0444	Belongs to the ABC transporter superfamily
ITG12_16280	COG0435	Glutathione S-transferase
ITG12_16290	COG3174	membrane
ITG12_16295	COG0280	phosphate acetyltransferase
ITG12_16295	COG0857	belongs to the CobB CobQ family
ITG12_16315	COG4120	Belongs to the binding-protein-dependent transport system permease family
ITG12_16320	COG1122	ATPase activity
ITG12_16325	COG0366	Alpha amylase catalytic
ITG12_16330	COG3706	GGDEF domain
ITG12_16335	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ITG12_16340	COG3012	SEC-C Motif Domain Protein
ITG12_16340	COG3318	Belongs to the UPF0149 family
ITG12_16345	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
ITG12_16355	COG2186	Transcriptional regulator
ITG12_16365	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ITG12_16365	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ITG12_16380	COG2982	Protein involved in outer membrane biogenesis
ITG12_16385	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
ITG12_16390	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ITG12_16395	COG0659	secondary active sulfate transmembrane transporter activity
ITG12_16400	COG1530	ribonuclease E activity
ITG12_16405	COG0564	pseudouridine synthase activity
ITG12_16410	COG0424	maF-like protein
ITG12_16415	COG1399	metal-binding, possibly nucleic acid-binding protein
ITG12_16430	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ITG12_16460	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
ITG12_16475	COG0084	hydrolase, TatD family'
ITG12_16480	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ITG12_16480	COG1263	PTS System
ITG12_16495	COG0733	neurotransmitter:sodium symporter activity
ITG12_16510	COG4667	esterase of the alpha-beta hydrolase superfamily
ITG12_16520	COG1940	carbohydrate kinase activity
ITG12_16525	COG0784	Response regulator, receiver
ITG12_16525	COG0835	chemotaxis
ITG12_16545	COG1028	Short-chain dehydrogenase reductase Sdr
ITG12_16550	COG0616	signal peptide processing
ITG12_16565	COG0539	negative regulation of cytoplasmic translation
ITG12_16575	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
ITG12_16580	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
ITG12_16590	COG4166	transmembrane transport
ITG12_16620	COG3119	arylsulfatase activity
ITG12_16625	COG1309	transcriptional regulator
ITG12_16630	COG3009	Protein conserved in bacteria
ITG12_16635	COG3008	intermembrane lipid transfer
ITG12_16635	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
ITG12_16640	COG2995	paraquat-inducible protein a
ITG12_16645	COG1609	Transcriptional regulator
ITG12_16650	COG3258	Cytochrome c
ITG12_16655	COG2863	cytochrome
ITG12_16685	COG3250	beta-galactosidase activity
ITG12_16695	COG4580	involved in the transport of maltose and maltodextrins
ITG12_16705	COG2211	Major facilitator Superfamily
ITG12_16710	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
ITG12_16725	COG4232	protein-disulfide reductase activity
ITG12_16730	COG3118	belongs to the thioredoxin family
ITG12_16755	COG3153	acetyltransferase
ITG12_16770	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ITG12_16790	COG0577	efflux transmembrane transporter activity
ITG12_16790	COG1136	(ABC) transporter
ITG12_16805	COG2176	DNA-directed DNA polymerase activity
ITG12_16830	COG2801	Transposase and inactivated derivatives
ITG12_16835	COG0840	transmembrane signaling receptor activity
ITG12_16845	COG0573	inorganic phosphate transmembrane transporter activity
ITG12_16850	COG0581	inorganic phosphate transmembrane transporter activity
ITG12_16855	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ITG12_16870	COG2304	oxidoreductase activity
ITG12_16890	COG0714	Associated with various cellular activities
ITG12_16910	COG0840	transmembrane signaling receptor activity
ITG12_16920	COG2197	response regulator
ITG12_16945	COG0110	maltose O-acetyltransferase activity
ITG12_16955	COG4191	Histidine kinase
ITG12_16965	COG0573	inorganic phosphate transmembrane transporter activity
ITG12_16975	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ITG12_16980	COG1028	Short-chain dehydrogenase reductase Sdr
ITG12_17025	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ITG12_17030	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ITG12_17035	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
ITG12_17090	COG1252	NADH dehydrogenase
ITG12_17095	COG1301	dicarboxylic acid transport
ITG12_17105	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ITG12_17135	COG1566	PFAM secretion protein HlyD family protein
ITG12_17140	COG0583	DNA-binding transcription factor activity
ITG12_17165	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ITG12_17165	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ITG12_17165	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ITG12_17170	COG2207	Transcriptional regulator
ITG12_17180	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ITG12_17185	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ITG12_17190	COG0583	DNA-binding transcription factor activity
ITG12_17200	COG2084	Dehydrogenase
ITG12_17205	COG0753	catalase activity
ITG12_17215	COG2130	NADP-dependent
ITG12_17220	COG1309	transcriptional regulator
ITG12_17270	COG3206	protein involved in exopolysaccharide biosynthesis
ITG12_17270	COG0489	protein tyrosine kinase activity
ITG12_17285	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
ITG12_17290	COG3842	ATPase activity
ITG12_17300	COG1175	transmembrane transport
ITG12_17305	COG3833	ABC-type maltose transport systems, permease component
ITG12_17335	COG2354	Protein conserved in bacteria
ITG12_17345	COG0401	homolog of Blt101
ITG12_17350	COG3217	Mosc domain protein beta barrel domain protein
ITG12_17350	COG0633	Ferredoxin
ITG12_17350	COG3217	Mosc domain protein beta barrel domain protein
ITG12_17350	COG0633	Ferredoxin
ITG12_17360	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
ITG12_17400	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
ITG12_17405	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ITG12_17415	COG0848	biopolymer transport protein
ITG12_17420	COG0811	peptide transport
ITG12_17425	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
ITG12_17435	COG3721	Heme iron utilization protein
ITG12_17440	COG0748	coenzyme F420 binding
ITG12_17455	COG0835	chemotaxis
ITG12_17455	COG0784	Response regulator, receiver
ITG12_17460	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ITG12_17465	COG0366	Alpha amylase catalytic
ITG12_17470	COG3321	synthase
ITG12_17470	COG1028	Short-chain dehydrogenase reductase Sdr
ITG12_17470	COG0604	alcohol dehydrogenase
ITG12_17510	COG0583	DNA-binding transcription factor activity
ITG12_17525	COG2249	NAD(P)H dehydrogenase (quinone) activity
ITG12_17530	COG0583	DNA-binding transcription factor activity
ITG12_17565	COG1335	isochorismatase
ITG12_17580	COG2194	sulfuric ester hydrolase activity
ITG12_17585	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
ITG12_17595	COG2205	protein histidine kinase activity
ITG12_17600	COG0745	RESPONSE REGULATOR receiver
ITG12_17620	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
ITG12_17625	COG4948	Mandelate Racemase Muconate Lactonizing
ITG12_17630	COG3976	FMN-binding domain protein
ITG12_17630	COG1053	succinate dehydrogenase
ITG12_17640	COG4221	oxidoreductase activity
ITG12_17655	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ITG12_17675	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ITG12_17685	COG2814	Major facilitator Superfamily
ITG12_17700	COG1418	mRNA catabolic process
ITG12_17715	COG0402	S-adenosylhomocysteine deaminase activity
ITG12_17720	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
ITG12_17725	COG2239	Acts as a magnesium transporter
ITG12_17730	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
ITG12_17735	COG1566	PFAM secretion protein HlyD family protein
ITG12_17760	COG0745	RESPONSE REGULATOR receiver
ITG12_17765	COG2205	protein histidine kinase activity
ITG12_17780	COG0531	amino acid
ITG12_17785	COG1522	sequence-specific DNA binding
ITG12_17795	COG0583	DNA-binding transcription factor activity
ITG12_17815	COG5002	protein histidine kinase activity
ITG12_17815	COG2205	protein histidine kinase activity
ITG12_17815	COG0784	Response regulator, receiver
ITG12_17820	COG0673	inositol 2-dehydrogenase activity
ITG12_17825	COG0534	Mate efflux family protein
ITG12_17895	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ITG12_17900	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ITG12_17910	COG1280	lysine exporter protein (LysE YggA)
ITG12_17920	COG0183	Belongs to the thiolase family
ITG12_17940	COG3005	denitrification pathway
ITG12_17960	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
ITG12_17965	COG3850	Histidine kinase
ITG12_17970	COG2197	response regulator
ITG12_17985	COG2195	Cleaves the N-terminal amino acid of tripeptides
ITG12_18010	COG0840	transmembrane signaling receptor activity
ITG12_18020	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ITG12_18025	COG2197	response regulator
ITG12_18050	COG0545	Peptidyl-prolyl cis-trans isomerase
ITG12_18080	COG1278	Cold shock
ITG12_18085	COG3036	rescue of stalled ribosome
ITG12_18095	COG2199	diguanylate cyclase activity
ITG12_18115	COG0577	efflux transmembrane transporter activity
ITG12_18115	COG1136	(ABC) transporter
ITG12_18140	COG1132	(ABC) transporter
ITG12_18145	COG1538	Outer membrane efflux protein
ITG12_18150	COG2205	protein histidine kinase activity
ITG12_18150	COG0784	Response regulator, receiver
ITG12_18175	COG0840	transmembrane signaling receptor activity
ITG12_18185	COG0783	Belongs to the Dps family
ITG12_18195	COG1619	proteins homologs of microcin C7 resistance protein MccF
ITG12_18200	COG2133	pyrroloquinoline quinone binding
ITG12_18205	COG1454	alcohol dehydrogenase
ITG12_18210	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
ITG12_18235	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ITG12_18240	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ITG12_18245	COG3186	Phenylalanine-4-hydroxylase
ITG12_18275	COG3530	Putative quorum-sensing-regulated virulence factor
ITG12_18310	COG0523	cobalamin synthesis protein
ITG12_18330	COG0513	Belongs to the DEAD box helicase family
ITG12_18350	COG3300	MHYT domain
ITG12_18350	COG5001	Diguanylate cyclase
ITG12_18355	COG1119	ATPase activity
ITG12_18370	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
ITG12_18385	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
ITG12_18390	COG0513	Belongs to the DEAD box helicase family
ITG12_18395	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
ITG12_18410	COG3278	Belongs to the heme-copper respiratory oxidase family
ITG12_18440	COG1024	Enoyl-CoA hydratase
ITG12_18445	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
ITG12_18450	COG1960	acyl-CoA dehydrogenase activity
ITG12_18460	COG0183	Belongs to the thiolase family
ITG12_18475	COG1024	Enoyl-CoA hydratase
ITG12_18480	COG1024	Enoyl-CoA hydratase
ITG12_18490	COG1028	Short-chain dehydrogenase reductase Sdr
ITG12_18500	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
ITG12_18505	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ITG12_18510	COG1845	cytochrome c oxidase, subunit III
ITG12_18515	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
ITG12_18535	COG0446	pyridine nucleotide-disulphide oxidoreductase
ITG12_18535	COG1902	pentaerythritol trinitrate reductase activity
ITG12_18560	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
ITG12_18600	COG1126	abc transporter atp-binding protein
ITG12_18605	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ITG12_18610	COG4215	(ABC) transporter
ITG12_18615	COG4160	amino acid transport
ITG12_18645	COG3119	arylsulfatase activity
ITG12_18690	COG0443	Heat shock 70 kDa protein
ITG12_18695	COG2847	Copper chaperone PCu(A)C
ITG12_18725	COG0745	RESPONSE REGULATOR receiver
ITG12_18740	COG1785	Belongs to the alkaline phosphatase family
ITG12_18765	COG0814	amino acid
ITG12_18770	COG5001	Diguanylate cyclase
ITG12_18770	COG5002	protein histidine kinase activity
ITG12_18780	COG0243	molybdopterin cofactor binding
ITG12_18800	COG3707	response regulator
ITG12_18805	COG1116	anion transmembrane transporter activity
ITG12_18805	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ITG12_18810	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ITG12_18815	COG1116	anion transmembrane transporter activity
ITG12_18820	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ITG12_18820	COG2146	nitrite reductase [NAD(P)H] activity
ITG12_18855	COG2165	general secretion pathway protein
ITG12_18865	COG2165	general secretion pathway protein
ITG12_18870	COG0745	RESPONSE REGULATOR receiver
ITG12_18875	COG2205	protein histidine kinase activity
ITG12_18875	COG2770	Histidine kinase
ITG12_18890	COG1294	oxidase, subunit
ITG12_18895	COG1271	oxidase subunit
ITG12_18905	COG0583	DNA-binding transcription factor activity
ITG12_18915	COG0739	heme binding
ITG12_18950	COG0628	permease
ITG12_18980	COG0604	alcohol dehydrogenase
ITG12_18980	COG3321	synthase
ITG12_18985	COG1024	Enoyl-CoA hydratase
ITG12_19000	COG0523	cobalamin synthesis protein
ITG12_19020	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
ITG12_19035	COG2207	Transcriptional regulator
ITG12_19035	COG0662	Cupin 2, conserved barrel domain protein
ITG12_19130	COG1132	(ABC) transporter
ITG12_19165	COG1733	regulation of RNA biosynthetic process
ITG12_19200	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
ITG12_19210	COG0404	The glycine cleavage system catalyzes the degradation of glycine
ITG12_19220	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ITG12_19225	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ITG12_19255	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ITG12_19255	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ITG12_19255	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
ITG12_19260	COG1105	Belongs to the carbohydrate kinase PfkB family
ITG12_19265	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ITG12_19265	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
ITG12_19270	COG1609	Transcriptional regulator
ITG12_19285	COG2199	diguanylate cyclase activity
ITG12_19285	COG2200	EAL domain
ITG12_19285	COG2203	Gaf domain
ITG12_19290	COG0765	amino acid transport
ITG12_19295	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ITG12_19300	COG0765	amino acid transport
ITG12_19305	COG1126	abc transporter atp-binding protein
ITG12_19315	COG1979	alcohol dehydrogenase
ITG12_19320	COG2207	Transcriptional regulator
ITG12_19330	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
ITG12_19340	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ITG12_19355	COG3437	response regulator, receiver
ITG12_19355	COG0784	Response regulator, receiver
ITG12_19360	COG0546	phosphoglycolate phosphatase activity
ITG12_19365	COG0840	transmembrane signaling receptor activity
ITG12_19370	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
ITG12_19375	COG0513	Belongs to the DEAD box helicase family
ITG12_19380	COG4943	cyclic-guanylate-specific phosphodiesterase activity
ITG12_19395	COG3038	cytochrome b561
ITG12_19405	COG2116	formate transmembrane transporter activity
ITG12_19410	COG0583	DNA-binding transcription factor activity
ITG12_19420	COG3593	DNA synthesis involved in DNA repair
ITG12_19425	COG0737	Belongs to the 5'-nucleotidase family
ITG12_19430	COG0861	Integral membrane protein TerC family
ITG12_19445	COG0646	methionine synthase
ITG12_19445	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
ITG12_19460	COG2267	carboxylic ester hydrolase activity
ITG12_19465	COG2067	long-chain fatty acid transport protein
ITG12_19480	COG2050	protein possibly involved in aromatic compounds catabolism
ITG12_19515	COG0484	heat shock protein binding
ITG12_19525	COG5001	Diguanylate cyclase
ITG12_19525	COG1716	ATPase activity
ITG12_19530	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
ITG12_19540	COG4181	ATPase activity
ITG12_19545	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
ITG12_19555	COG1984	allophanate hydrolase subunit 2
ITG12_19560	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
ITG12_19570	COG3447	MASE1 domain protein
ITG12_19570	COG5001	Diguanylate cyclase
ITG12_19570	COG5002	protein histidine kinase activity
ITG12_19575	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
ITG12_19585	COG0583	DNA-binding transcription factor activity
ITG12_19590	COG1042	CoA-binding domain protein
ITG12_19590	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ITG12_19590	COG0045	succinate-CoA ligase (ADP-forming) activity
ITG12_19610	COG0023	Translation Initiation Factor
ITG12_19660	COG4128	Pfam Zonular occludens toxin
ITG12_19690	COG2801	Transposase and inactivated derivatives
ITG12_19710	COG3140	Belongs to the UPF0181 family
ITG12_19725	COG0745	RESPONSE REGULATOR receiver
ITG12_19735	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
ITG12_19740	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
ITG12_19770	COG2203	Gaf domain
ITG12_19770	COG4251	negative regulation of phosphorylation
ITG12_19770	COG5001	Diguanylate cyclase
ITG12_19770	COG3706	GGDEF domain
ITG12_19780	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
ITG12_19785	COG4149	molybdate abc transporter
ITG12_19790	COG0725	ABC transporter, periplasmic molybdate-binding protein
ITG12_19800	COG3111	PFAM Bacterial OB fold (BOF) protein
ITG12_19820	COG2207	Transcriptional regulator
ITG12_19825	COG0534	Mate efflux family protein
ITG12_19830	COG0602	queuosine metabolic process
ITG12_19835	COG1328	CTP reductase activity
ITG12_19895	COG2197	response regulator
ITG12_19900	COG3851	Histidine kinase
ITG12_19905	COG2271	Major facilitator Superfamily
ITG12_19910	COG1482	cell wall glycoprotein biosynthetic process
ITG12_19920	COG0628	permease
ITG12_19930	COG1566	PFAM secretion protein HlyD family protein
ITG12_19960	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ITG12_19965	COG3118	belongs to the thioredoxin family
ITG12_19975	COG3292	Two component regulator propeller
ITG12_19975	COG2205	protein histidine kinase activity
ITG12_19975	COG0745	RESPONSE REGULATOR receiver
ITG12_19980	COG0534	Mate efflux family protein
ITG12_20000	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
ITG12_20020	COG2116	formate transmembrane transporter activity
ITG12_20030	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ITG12_20040	COG2199	diguanylate cyclase activity
ITG12_20090	COG0277	FAD linked oxidase domain protein
ITG12_20095	COG0583	DNA-binding transcription factor activity
ITG12_20100	COG1472	Belongs to the glycosyl hydrolase 3 family
ITG12_20110	COG2425	protein containing a von Willebrand factor type A (vWA) domain
ITG12_20125	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
ITG12_20135	COG1288	antiporter activity
ITG12_20145	COG3040	lipid binding
ITG12_20175	COG3469	chitinase activity
ITG12_20190	COG0419	ATPase involved in DNA repair
ITG12_20195	COG0420	3'-5' exonuclease activity
ITG12_20215	COG3209	COG3209 Rhs family protein
ITG12_20285	COG0631	protein serine/threonine phosphatase activity
ITG12_20320	COG2815	serine threonine protein kinase
ITG12_20320	COG0515	serine threonine protein kinase
ITG12_20355	COG0346	lactoylglutathione lyase activity
ITG12_20360	COG1902	pentaerythritol trinitrate reductase activity
ITG12_20370	COG0463	Glycosyl transferase, family 2
ITG12_20370	COG1216	Glycosyl transferase, family 2
ITG12_20380	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
ITG12_20380	COG2755	lipolytic protein G-D-S-L family
ITG12_20390	COG5642	Protein of unknown function (DUF2384)
ITG12_20395	COG2067	long-chain fatty acid transport protein
ITG12_20440	COG0671	phosphoesterase, PA-phosphatase related
ITG12_20455	COG2962	Rard protein
ITG12_20465	COG2165	general secretion pathway protein
ITG12_20470	COG0784	Response regulator, receiver
ITG12_20470	COG0835	chemotaxis
ITG12_20475	COG0778	Nitroreductase
ITG12_20485	COG2197	response regulator
ITG12_20495	COG3706	GGDEF domain
ITG12_20500	COG2197	response regulator
ITG12_20505	COG3300	MHYT domain
ITG12_20505	COG5001	Diguanylate cyclase
ITG12_20525	COG4771	TonB-dependent receptor
ITG12_20590	COG1522	sequence-specific DNA binding
ITG12_20625	COG0515	serine threonine protein kinase
ITG12_20650	COG3501	Rhs element vgr protein
ITG12_20665	COG2204	response regulator
ITG12_20690	COG0739	heme binding
ITG12_20695	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
ITG12_20725	COG3069	C4-dicarboxylate transmembrane transporter activity
ITG12_20730	COG1704	LemA family
ITG12_20760	COG0641	radical SAM
ITG12_20780	COG3111	PFAM Bacterial OB fold (BOF) protein
ITG12_20785	COG1597	lipid kinase activity
ITG12_20800	COG0355	proton-transporting ATP synthase activity, rotational mechanism
ITG12_20810	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
ITG12_20870	COG0714	Associated with various cellular activities
ITG12_20875	COG0641	radical SAM
ITG12_20880	COG3119	arylsulfatase activity
ITG12_20885	COG0583	DNA-binding transcription factor activity
ITG12_20890	COG3063	Type IV pilus biogenesis stability protein PilW
ITG12_20895	COG3119	arylsulfatase activity
ITG12_20900	COG3119	arylsulfatase activity
ITG12_20930	COG0784	Response regulator, receiver
ITG12_20930	COG2198	Histidine kinase
ITG12_20930	COG2205	protein histidine kinase activity
ITG12_20935	COG1879	ABC-type sugar transport system periplasmic component
ITG12_20945	COG0210	DNA helicase
ITG12_20950	COG1289	transmembrane transporter activity
ITG12_20985	COG4206	TonB-dependent receptor
ITG12_20995	COG0789	Transcriptional regulator
ITG12_21000	COG4604	ABC transporter, ATP-binding protein
ITG12_21005	COG4605	iron ion homeostasis
ITG12_21010	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ITG12_21015	COG4607	ABC-type enterochelin transport system periplasmic component
ITG12_21045	COG1609	Transcriptional regulator
ITG12_21050	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ITG12_21060	COG1172	Belongs to the binding-protein-dependent transport system permease family
ITG12_21065	COG1129	ABC transporter
ITG12_21075	COG5001	Diguanylate cyclase
ITG12_21080	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
ITG12_21085	COG1794	racemase activity, acting on amino acids and derivatives
ITG12_21090	COG1051	belongs to the nudix hydrolase family
ITG12_21095	COG0494	nUDIX hydrolase
ITG12_21155	COG2205	protein histidine kinase activity
ITG12_21155	COG0784	Response regulator, receiver
ITG12_21165	COG0784	Response regulator, receiver
ITG12_21165	COG2205	protein histidine kinase activity
ITG12_21170	COG5001	Diguanylate cyclase
ITG12_21170	COG3706	GGDEF domain
ITG12_21170	COG2203	Gaf domain
ITG12_21170	COG4251	negative regulation of phosphorylation
ITG12_21190	COG0330	HflC and HflK could
ITG12_21205	COG0517	IMP dehydrogenase activity
ITG12_21205	COG4175	Glycine betaine
ITG12_21210	COG4176	ABC-type proline glycine betaine transport system permease component
ITG12_21235	COG3706	GGDEF domain
ITG12_21250	COG0402	S-adenosylhomocysteine deaminase activity
ITG12_21275	COG2885	chlorophyll binding
ITG12_21315	COG0455	bacterial-type flagellum organization
ITG12_21325	COG4964	Belongs to the GSP D family
ITG12_21345	COG0583	DNA-binding transcription factor activity
ITG12_21350	COG1073	alpha beta
ITG12_21370	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
ITG12_21370	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
ITG12_21385	COG4989	oxidoreductase activity
ITG12_21410	COG1914	H( )-stimulated, divalent metal cation uptake system
ITG12_21425	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ITG12_21485	COG2897	thiosulfate sulfurtransferase activity
ITG12_21510	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
ITG12_21520	COG2814	Major facilitator Superfamily
ITG12_21525	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ITG12_21540	COG1612	heme a metabolic process
ITG12_21560	COG1845	cytochrome c oxidase, subunit III
ITG12_21565	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
ITG12_21580	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ITG12_21590	COG1280	lysine exporter protein (LysE YggA)
ITG12_21610	COG0179	Fumarylacetoacetate (FAA) hydrolase
ITG12_21625	COG0697	spore germination
ITG12_21640	COG2814	Major facilitator Superfamily
ITG12_21645	COG0583	DNA-binding transcription factor activity
ITG12_21665	COG3708	Transcriptional regulator
ITG12_21665	COG2207	Transcriptional regulator
ITG12_21675	COG1120	ATPase activity
ITG12_21680	COG5001	Diguanylate cyclase
ITG12_21685	COG0739	heme binding
ITG12_21705	COG3314	Sporulation integral membrane protein YlbJ
ITG12_21720	COG0814	amino acid
ITG12_21740	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
ITG12_21745	COG1072	(Pantothenic acid kinase))
ITG12_21755	COG1063	alcohol dehydrogenase
ITG12_21760	COG2213	PTS system mannitol-specific
ITG12_21765	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ITG12_21770	COG2188	Transcriptional regulator
ITG12_21775	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ITG12_21775	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ITG12_21775	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ITG12_21780	COG0383	alpha-mannosidase activity
ITG12_21785	COG1482	cell wall glycoprotein biosynthetic process
ITG12_21795	COG4989	oxidoreductase activity
ITG12_21815	COG0798	PFAM Bile acid sodium symporter
ITG12_21830	COG1881	PFAM PEBP family protein
ITG12_21840	COG0251	oxidation-reduction process
ITG12_21845	COG2706	6-phosphogluconolactonase activity
ITG12_21855	COG0800	Aldolase
ITG12_21860	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ITG12_21865	COG4145	pantothenate transmembrane transporter activity
ITG12_21875	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
ITG12_21890	COG0840	transmembrane signaling receptor activity
ITG12_21900	COG1131	(ABC) transporter
ITG12_21905	COG0842	Transport permease protein
ITG12_21925	COG3383	formate dehydrogenase (NAD+) activity
ITG12_21945	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ITG12_21985	COG0604	alcohol dehydrogenase
ITG12_21985	COG3321	synthase
ITG12_21985	COG1028	Short-chain dehydrogenase reductase Sdr
ITG12_22005	COG0494	nUDIX hydrolase
ITG12_22020	COG1858	cytochrome C peroxidase
ITG12_22030	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ITG12_22040	COG2067	long-chain fatty acid transport protein
ITG12_22050	COG1505	serine-type exopeptidase activity
ITG12_22055	COG0488	(ABC) transporter
ITG12_22060	COG1720	tRNA m6t6A37 methyltransferase activity
ITG12_22080	COG0589	response to stress
ITG12_22110	COG1175	transmembrane transport
ITG12_22115	COG0395	ABC-type sugar transport system, permease component
ITG12_22120	COG3842	ATPase activity
ITG12_22150	COG0523	cobalamin synthesis protein
ITG12_22155	COG4451	ribulose bisphosphate carboxylase, small
ITG12_22155	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
ITG12_22160	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ITG12_22170	COG4667	esterase of the alpha-beta hydrolase superfamily
ITG12_22175	COG1741	Belongs to the pirin family
ITG12_22180	COG1278	Cold shock
ITG12_22190	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
ITG12_22200	COG0583	DNA-binding transcription factor activity
ITG12_22220	COG2226	methyltransferase
ITG12_22230	COG1686	Belongs to the peptidase S11 family
ITG12_22235	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
ITG12_22240	COG0625	glutathione transferase activity
ITG12_22250	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
ITG12_22275	COG1278	Cold shock
ITG12_22295	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
ITG12_22305	COG1028	Short-chain dehydrogenase reductase Sdr
ITG12_22330	COG3746	phosphate-selective porin O and P
ITG12_22345	COG1028	Short-chain dehydrogenase reductase Sdr
ITG12_22355	COG0583	DNA-binding transcription factor activity
ITG12_22360	COG2207	Transcriptional regulator
ITG12_22360	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ITG12_22365	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ITG12_22415	COG0513	Belongs to the DEAD box helicase family
ITG12_22435	COG3501	Rhs element vgr protein
ITG12_22445	COG0583	DNA-binding transcription factor activity
ITG12_22455	COG0583	DNA-binding transcription factor activity
ITG12_22475	COG1028	Short-chain dehydrogenase reductase Sdr
ITG12_22480	COG2814	Major facilitator Superfamily
ITG12_22490	COG1902	pentaerythritol trinitrate reductase activity
ITG12_22500	COG3853	Toxic anion resistance protein (TelA)
ITG12_22510	COG2255	four-way junction helicase activity
ITG12_22525	COG3122	Protein conserved in bacteria
ITG12_22540	COG0583	DNA-binding transcription factor activity
ITG12_22545	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
ITG12_22560	COG0252	asparaginase activity
ITG12_22570	COG2807	transmembrane transport
ITG12_22580	COG0574	Belongs to the PEP-utilizing enzyme family
ITG12_22580	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ITG12_22590	COG2197	response regulator
ITG12_22595	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
ITG12_22630	COG0583	DNA-binding transcription factor activity
ITG12_22635	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ITG12_22655	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
ITG12_22660	COG0786	glutamate:sodium symporter activity
ITG12_22690	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
ITG12_22695	COG0318	PFAM AMP-dependent synthetase and ligase
ITG12_22715	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ITG12_22725	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ITG12_22735	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ITG12_22775	COG4948	Mandelate Racemase Muconate Lactonizing
ITG12_22780	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ITG12_22800	COG1342	Belongs to the UPF0251 family
ITG12_22810	COG4176	ABC-type proline glycine betaine transport system permease component
ITG12_22815	COG3448	diguanylate cyclase activity
ITG12_22815	COG4175	Glycine betaine
ITG12_22830	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
ITG12_22835	COG0583	DNA-binding transcription factor activity
ITG12_22845	COG2801	Transposase and inactivated derivatives
ITG12_22850	COG2801	Transposase and inactivated derivatives
ITG12_22855	COG2963	transposase activity
ITG12_22895	COG1335	isochorismatase
ITG12_22910	COG0753	catalase activity
ITG12_22935	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
ITG12_22940	COG1263	PTS System
ITG12_22940	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ITG12_22945	COG1609	Transcriptional regulator
ITG12_22950	COG1349	DNA-binding transcription factor activity
ITG12_22955	COG0346	lactoylglutathione lyase activity
ITG12_22960	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ITG12_22960	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ITG12_22970	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ITG12_22975	COG3537	Alpha-1,2-mannosidase
ITG12_22980	COG3537	Alpha-1,2-mannosidase
ITG12_22990	COG3537	Alpha-1,2-mannosidase
ITG12_22995	COG3537	Alpha-1,2-mannosidase
ITG12_23035	COG1280	lysine exporter protein (LysE YggA)
ITG12_23040	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ITG12_23055	COG3226	Transcriptional regulator
ITG12_23065	COG0583	DNA-binding transcription factor activity
ITG12_23080	COG0488	(ABC) transporter
ITG12_23100	COG0431	NADPH-dependent FMN reductase
ITG12_23105	COG0583	DNA-binding transcription factor activity
ITG12_23110	COG4628	conserved protein (DUF2132)
ITG12_23115	COG0488	(ABC) transporter
ITG12_23130	COG0346	lactoylglutathione lyase activity
ITG12_23135	COG0384	phenazine biosynthesis protein PhzF
ITG12_23150	COG3220	belongs to the UPF0276 family
ITG12_23165	COG1271	oxidase subunit
ITG12_23170	COG1294	oxidase, subunit
ITG12_23195	COG1882	Formate acetyltransferase
ITG12_23200	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
ITG12_23205	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ITG12_23220	COG2205	protein histidine kinase activity
ITG12_23225	COG0745	RESPONSE REGULATOR receiver
ITG12_23235	COG0454	-acetyltransferase
ITG12_23240	COG0148	phosphopyruvate hydratase activity
ITG12_23250	COG2814	Major facilitator Superfamily
ITG12_23280	COG0583	DNA-binding transcription factor activity
ITG12_23285	COG2988	succinylglutamate desuccinylase activity
ITG12_23325	COG0628	permease
ITG12_23330	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
ITG12_23335	COG2801	Transposase and inactivated derivatives
ITG12_23340	COG2801	Transposase and inactivated derivatives
ITG12_23360	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ITG12_23370	COG4628	conserved protein (DUF2132)
ITG12_23375	COG0583	DNA-binding transcription factor activity
ITG12_23400	COG1686	Belongs to the peptidase S11 family
ITG12_23420	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ITG12_23425	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ITG12_23450	COG0415	Belongs to the DNA photolyase family
ITG12_23455	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
ITG12_23465	COG4667	esterase of the alpha-beta hydrolase superfamily
ITG12_23470	COG2095	MarC family integral membrane protein
ITG12_23480	COG1596	polysaccharide export
ITG12_23490	COG3206	protein involved in exopolysaccharide biosynthesis
ITG12_23490	COG0489	protein tyrosine kinase activity
ITG12_23510	COG0583	DNA-binding transcription factor activity
ITG12_23540	COG1301	dicarboxylic acid transport
ITG12_23550	COG3339	Conserved Protein
ITG12_23555	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ITG12_23560	COG0700	Nucleoside recognition
ITG12_23565	COG3366	ferrous iron transmembrane transporter activity
ITG12_23590	COG0366	Alpha amylase catalytic
ITG12_23595	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ITG12_23600	COG1473	amidohydrolase
ITG12_23605	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
ITG12_23610	COG0583	DNA-binding transcription factor activity
ITG12_23615	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
ITG12_23620	COG1640	4-alpha-glucanotransferase
ITG12_23625	COG0058	SHG alpha-glucan phosphorylase activity
ITG12_23645	COG1999	signal sequence binding
ITG12_23660	COG1162	GTPase activity
ITG12_23665	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
ITG12_23670	COG0673	inositol 2-dehydrogenase activity
ITG12_23695	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ITG12_23700	COG0673	inositol 2-dehydrogenase activity
ITG12_23705	COG3962	Belongs to the TPP enzyme family
ITG12_23715	COG0477	Major facilitator Superfamily
ITG12_23715	COG2814	Major facilitator Superfamily
ITG12_23735	COG0183	Belongs to the thiolase family
ITG12_23740	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
ITG12_23765	COG0531	amino acid
ITG12_23770	COG1982	Orn Lys Arg decarboxylase major
ITG12_23790	COG2356	endonuclease I
ITG12_23795	COG0366	Alpha amylase catalytic
ITG12_23820	COG2203	Gaf domain
ITG12_23820	COG2199	diguanylate cyclase activity
ITG12_23850	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
ITG12_23865	COG2814	Major facilitator Superfamily
ITG12_23870	COG3214	Protein conserved in bacteria
ITG12_23880	COG4771	TonB-dependent receptor
ITG12_23885	COG0583	DNA-binding transcription factor activity
ITG12_23890	COG4607	ABC-type enterochelin transport system periplasmic component
ITG12_23895	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ITG12_23900	COG4605	iron ion homeostasis
ITG12_23905	COG4604	ABC transporter, ATP-binding protein
ITG12_23910	COG1309	transcriptional regulator
ITG12_23930	COG0739	heme binding
ITG12_23945	COG0800	Aldolase
ITG12_23950	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ITG12_23955	COG2190	(PTS) system
ITG12_23955	COG1263	PTS System
ITG12_23955	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ITG12_23965	COG2188	Transcriptional regulator
ITG12_23970	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
ITG12_23975	COG3876	Protein conserved in bacteria
ITG12_23980	COG1472	Belongs to the glycosyl hydrolase 3 family
ITG12_24000	COG3121	Chaperone
ITG12_24005	COG3188	usher protein
ITG12_24035	COG0612	Peptidase, M16
ITG12_24050	COG0826	peptidase U32
ITG12_24080	COG0583	DNA-binding transcription factor activity
ITG12_24095	COG1136	(ABC) transporter
ITG12_24100	COG0577	efflux transmembrane transporter activity
ITG12_24155	COG1764	response to oxidative stress
ITG12_24160	COG1846	Transcriptional regulator
ITG12_24170	COG3634	alkyl hydroperoxide reductase activity
ITG12_24190	COG2610	gluconate transmembrane transporter activity
ITG12_24195	COG3622	Belongs to the hyi family
ITG12_24200	COG0235	Class ii aldolase
ITG12_24205	COG3395	kinase activity
ITG12_24210	COG2084	Dehydrogenase
ITG12_24215	COG1349	DNA-binding transcription factor activity
ITG12_24235	COG0346	lactoylglutathione lyase activity
ITG12_24245	COG0583	DNA-binding transcription factor activity
ITG12_24250	COG1486	melibiose metabolic process
ITG12_24265	COG1522	sequence-specific DNA binding
ITG12_24280	COG2258	MOSC domain
ITG12_24285	COG2153	protein acetylation
ITG12_24295	COG1609	Transcriptional regulator
ITG12_24300	COG1757	Na H antiporter
ITG12_24305	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
ITG12_24310	COG3713	MltA-interacting MipA family protein
ITG12_24315	COG0513	Belongs to the DEAD box helicase family
ITG12_24335	COG1312	Catalyzes the dehydration of D-mannonate
ITG12_24340	COG2186	Transcriptional regulator
ITG12_24350	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
ITG12_24360	COG0246	Mannitol dehydrogenase
ITG12_24365	COG1904	glucuronate isomerase
ITG12_24370	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ITG12_24375	COG0800	Aldolase
ITG12_24400	COG0549	Belongs to the carbamate kinase family
ITG12_24405	COG0531	amino acid
ITG12_24410	COG2957	Belongs to the agmatine deiminase family
ITG12_24435	COG1132	(ABC) transporter
ITG12_24460	COG0406	alpha-ribazole phosphatase activity
ITG12_24485	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ITG12_24555	COG4166	transmembrane transport
ITG12_24570	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
ITG12_24575	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ITG12_24575	COG1263	PTS System
ITG12_24580	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
ITG12_24590	COG0583	DNA-binding transcription factor activity
ITG12_24605	COG1444	tRNA N-acetyltransferase activity
ITG12_24630	COG4608	Belongs to the ABC transporter superfamily
ITG12_24635	COG0444	Belongs to the ABC transporter superfamily
ITG12_24645	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ITG12_24645	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
ITG12_24670	COG0772	Belongs to the SEDS family
ITG12_24680	COG1566	PFAM secretion protein HlyD family protein
ITG12_24685	COG0583	DNA-binding transcription factor activity
ITG12_24695	COG1136	(ABC) transporter
ITG12_24715	COG3275	phosphorelay sensor kinase activity
ITG12_24720	COG3279	Response regulator of the LytR AlgR family
ITG12_24730	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ITG12_24755	COG0786	glutamate:sodium symporter activity
ITG12_24760	COG1028	Short-chain dehydrogenase reductase Sdr
ITG12_24795	COG1131	(ABC) transporter
ITG12_24800	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ITG12_24805	COG0786	glutamate:sodium symporter activity
ITG12_24825	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ITG12_24840	COG0829	nickel cation binding
ITG12_24845	COG0831	urea catabolic process
ITG12_24850	COG0832	Belongs to the urease beta subunit family
ITG12_24855	COG0804	urea catabolic process
ITG12_24860	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
ITG12_24865	COG0830	nickel cation binding
ITG12_24870	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
ITG12_24880	COG2207	Transcriptional regulator
ITG12_24885	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
ITG12_24895	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ITG12_24910	COG0251	oxidation-reduction process
ITG12_24915	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ITG12_24965	COG0561	phosphatase activity
ITG12_24970	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
ITG12_24975	COG3623	hexulose-6-phosphate isomerase
ITG12_25010	COG2259	Doxx family
ITG12_25020	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
ITG12_25025	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ITG12_25040	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ITG12_25090	COG5001	Diguanylate cyclase
ITG12_25095	COG4580	involved in the transport of maltose and maltodextrins
ITG12_25100	COG1609	Transcriptional regulator
ITG12_25115	COG0395	ABC-type sugar transport system, permease component
ITG12_25120	COG2723	6-phospho-beta-galactosidase activity
ITG12_25125	COG3842	ATPase activity
ITG12_25130	COG1609	Transcriptional regulator
ITG12_25135	COG0534	Mate efflux family protein
ITG12_25140	COG0564	pseudouridine synthase activity
ITG12_25145	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
ITG12_25155	COG0561	phosphatase activity
ITG12_25165	COG2199	diguanylate cyclase activity
ITG12_25175	COG3152	Membrane
ITG12_25190	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
ITG12_25210	COG0583	DNA-binding transcription factor activity
ITG12_25255	COG2076	Multidrug Resistance protein
ITG12_25270	COG0534	Mate efflux family protein
ITG12_25285	COG1357	PFAM Pentapeptide repeats (8 copies)
ITG12_25290	COG3047	cAMP biosynthetic process
ITG12_25295	COG2358	TRAP transporter, solute receptor (TAXI family
ITG12_25310	COG2814	Major facilitator Superfamily
ITG12_25330	COG3408	Glycogen debranching enzyme
ITG12_25330	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
ITG12_25360	COG0583	DNA-binding transcription factor activity
ITG12_25415	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ITG12_25425	COG0546	phosphoglycolate phosphatase activity
ITG12_25465	COG3835	regulator
ITG12_25470	COG1929	Belongs to the glycerate kinase type-1 family
ITG12_25475	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ITG12_25520	COG0456	acetyltransferase
ITG12_25540	COG1028	Short-chain dehydrogenase reductase Sdr
ITG12_25550	COG3005	denitrification pathway
ITG12_25555	COG0243	molybdopterin cofactor binding
ITG12_25585	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
ITG12_25590	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ITG12_25595	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ITG12_25600	COG1116	anion transmembrane transporter activity
ITG12_25605	COG0351	phosphomethylpyrimidine kinase
ITG12_25610	COG0312	modulator of DNA gyrase
ITG12_25615	COG0312	modulator of DNA gyrase
ITG12_25670	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ITG12_25680	COG0584	glycerophosphoryl diester phosphodiesterase
ITG12_25685	COG0745	RESPONSE REGULATOR receiver
ITG12_25705	COG0811	peptide transport
ITG12_25710	COG0811	peptide transport
ITG12_25715	COG0848	biopolymer transport protein
ITG12_25760	COG0803	Belongs to the bacterial solute-binding protein 9 family
ITG12_25765	COG1121	(ABC) transporter
ITG12_25770	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ITG12_25785	COG1770	oligopeptidase
ITG12_25790	COG2814	Major facilitator Superfamily
ITG12_25795	COG0010	Belongs to the arginase family
ITG12_25800	COG1166	arginine decarboxylase activity
ITG12_25810	COG4067	protein conserved in archaea
ITG12_25810	COG0189	ligase activity
ITG12_25815	COG0189	ligase activity
ITG12_25835	COG0583	DNA-binding transcription factor activity
ITG12_25875	COG1114	Component of the transport system for branched-chain amino acids
ITG12_25890	COG0579	oxidoreductase
ITG12_25895	COG3179	chitinase
ITG12_25915	COG3033	Beta-eliminating lyase
ITG12_25930	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ITG12_25935	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
ITG12_25955	COG3706	GGDEF domain
ITG12_25970	COG3706	GGDEF domain
ITG12_25975	COG0415	Belongs to the DNA photolyase family
ITG12_25980	COG3046	protein related to deoxyribodipyrimidine photolyase
ITG12_25995	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ITG12_25995	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ITG12_26000	COG1765	OsmC-like protein
ITG12_26025	COG1011	Hydrolase
ITG12_26065	COG3240	lipase activity
ITG12_26085	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
ITG12_26095	COG1840	ABC-type Fe3 transport system, periplasmic component
ITG12_26100	COG3842	ATPase activity
ITG12_26125	COG2990	Protein conserved in bacteria
ITG12_26135	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ITG12_26140	COG2866	Carboxypeptidase
ITG12_26150	COG0583	DNA-binding transcription factor activity
ITG12_26175	COG3104	oligopeptide transport
ITG12_26180	COG1760	l-serine dehydratase
ITG12_26205	COG1388	LysM domain
ITG12_26205	COG0741	lytic transglycosylase activity
ITG12_26225	COG1815	bacterial-type flagellum-dependent cell motility
ITG12_26230	COG1558	bacterial-type flagellum-dependent cell motility
ITG12_26235	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
ITG12_26240	COG1749	Flagellar hook protein flgE
ITG12_26245	COG4787	bacterial-type flagellum-dependent cell motility
ITG12_26250	COG4786	Flagellar basal body rod
ITG12_26255	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
ITG12_26260	COG1706	bacterial-type flagellum-dependent cell motility
ITG12_26270	COG4786	Flagellar basal body rod
ITG12_26270	COG1256	bacterial-type flagellum assembly
ITG12_26275	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ITG12_26300	COG0583	DNA-binding transcription factor activity
ITG12_26320	COG1522	sequence-specific DNA binding
ITG12_26330	COG1473	amidohydrolase
ITG12_26335	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
ITG12_26345	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
ITG12_26350	COG0006	proline dipeptidase activity
ITG12_26360	COG1253	flavin adenine dinucleotide binding
ITG12_26365	COG3710	Transcriptional regulator
ITG12_26415	COG0384	phenazine biosynthesis protein PhzF
ITG12_26440	COG1360	Flagellar Motor Protein
ITG12_26445	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
ITG12_26450	COG1191	sigma factor activity
ITG12_26455	COG1580	Controls the rotational direction of flagella during chemotaxis
ITG12_26470	COG1516	flagellar protein fliS
ITG12_26475	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
ITG12_26485	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ITG12_26500	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ITG12_26510	COG1987	bacterial-type flagellum assembly
ITG12_26570	COG2200	EAL domain
ITG12_26580	COG0583	DNA-binding transcription factor activity
ITG12_26630	COG0346	lactoylglutathione lyase activity
ITG12_26655	COG0745	RESPONSE REGULATOR receiver
ITG12_26680	COG0156	8-amino-7-oxononanoate synthase activity
ITG12_26685	COG1063	alcohol dehydrogenase
ITG12_26700	COG0668	transmembrane transport
ITG12_26715	COG1304	FMN binding
ITG12_26720	COG1620	l-lactate permease
ITG12_26725	COG0583	DNA-binding transcription factor activity
ITG12_26730	COG1505	serine-type exopeptidase activity
ITG12_26735	COG4172	Belongs to the ABC transporter superfamily
ITG12_26745	COG1067	ATP-dependent peptidase activity
ITG12_26755	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
ITG12_26775	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ITG12_26780	COG0437	4 iron, 4 sulfur cluster binding
ITG12_26785	COG0348	domain, Protein
ITG12_26815	COG1122	ATPase activity
ITG12_26825	COG1566	PFAM secretion protein HlyD family protein
ITG12_26855	COG0813	purine-nucleoside phosphorylase activity
ITG12_26860	COG3272	Protein of unknown function (DUF1722)
ITG12_26865	COG0789	Transcriptional regulator
ITG12_26870	COG0415	Belongs to the DNA photolyase family
ITG12_26875	COG1388	LysM domain
ITG12_26875	COG1376	ErfK ybiS ycfS ynhG family protein
ITG12_26885	COG0513	Belongs to the DEAD box helicase family
ITG12_26895	COG1770	oligopeptidase
ITG12_26900	COG4771	TonB-dependent receptor
ITG12_26980	COG2358	TRAP transporter, solute receptor (TAXI family
ITG12_27020	COG2200	EAL domain
ITG12_27035	COG2885	chlorophyll binding
ITG12_27035	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
ITG12_27105	COG2801	Transposase and inactivated derivatives
ITG12_27115	COG1192	Involved in chromosome partitioning
ITG12_27155	COG5268	conjugation
ITG12_27160	COG3451	type IV secretory pathway VirB4
ITG12_27170	COG4962	Type ii secretion system protein e
ITG12_27180	COG3701	Conjugal transfer protein
ITG12_27220	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ITG12_27255	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
ITG12_27505	COG1192	Involved in chromosome partitioning