locus-tag class description G7083_00005 ENOG4105C5H ABC transporter G7083_00010 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) G7083_00040 ENOG4108IEG Formate dehydrogenase Alpha subunit G7083_00040 ENOG4108IEG Formate dehydrogenase Alpha subunit G7083_00045 ENOG4105QAX Iron-sulfur G7083_00060 ENOG4108VPT UPF0234 protein G7083_00065 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) G7083_00075 ENOG4105QNR S1 RNA binding domain protein G7083_00085 ENOG4105DY2 Paraquat-inducible protein b G7083_00090 ENOG4105H2K paraquat-inducible protein a G7083_00095 ENOG4105BZ1 (ABC) transporter G7083_00100 ENOG4108ZGC gaf domain protein G7083_00105 ENOG41073DY may be a structural element that influences the osmotic activation of ProP at a post-translational level (By similarity) G7083_00110 ENOG4105CN1 protease G7083_00115 ENOG4105CD8 aminopeptidase N G7083_00125 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) G7083_00130 ENOG4108T7E Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity) G7083_00135 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) G7083_00145 ENOG4105C5H ABC transporter G7083_00160 ENOG4108RKI Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity) G7083_00165 ENOG4105DAN ATP-dependent protease G7083_00170 ENOG4108R9Q Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle. Prevents early segregation of duplicated Ter macrodomains during cell division. Binds specifically to matS, which is a 13 bp signature motif repeated within the Ter macrodomain (By similarity) G7083_00205 ENOG4105D6P C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex (By similarity) G7083_00215 ENOG4105C59 p-type ATPase G7083_00230 ENOG4105DS0 Transcriptional regulator, Crp Fnr family G7083_00235 ENOG4105Q9Y Universal stress protein G7083_00240 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) G7083_00255 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) G7083_00260 ENOG4105F38 ABC transporter, permease G7083_00265 ENOG4105D38 putrescine abc transporter G7083_00270 ENOG4108HM4 ABC transporter G7083_00275 ENOG4107RUE extracellular solute-binding protein family 1 G7083_00290 ENOG4105BZG amino acid carrier protein G7083_00305 ENOG4105CTD carboxy-peptidase G7083_00315 ENOG4105DFS Conserved Protein G7083_00330 ENOG4105CVR type I restriction-modification system G7083_00335 ENOG4105C0R drug resistance transporter emrb qaca subfamily G7083_00340 ENOG4105CW7 secretion protein, HlyD family G7083_00345 ENOG4105ENJ RND efflux system, outer membrane lipoprotein G7083_00355 ENOG4105C1J atp-dependent rna helicase G7083_00360 ENOG4105R8A Heat shock protein G7083_00385 ENOG4105CQ7 ATP-dependent helicase G7083_00410 ENOG4105CFG Acts as a chaperone (By similarity) G7083_00415 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB G7083_00430 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) G7083_00435 ENOG410667J hydrolase G7083_00445 ENOG4107QXX ABC transporter G7083_00450 ENOG4105EZ7 amino acid ABC transporter G7083_00455 ENOG4105DRP amino acid AbC transporter G7083_00460 ENOG4105CDA abc transporter atp-binding protein G7083_00465 ENOG4108MN8 Membrane G7083_00470 ENOG4108Z0T Part of a sulfur-relay system (By similarity) G7083_00475 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 G7083_00480 ENOG4105DR4 Methyltransferase G7083_00485 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) G7083_00500 ENOG4105ETT transcriptional Regulator, LysR family G7083_00505 ENOG4105CJP fad dependent oxidoreductase G7083_00515 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family G7083_00520 ENOG4105BZU Histidine kinase G7083_00525 ENOG4105C8P )-transporter G7083_00540 ENOG4105D9U N-acetyltransferase G7083_00545 ENOG4108JU8 Transcriptional regulator G7083_00555 ENOG4105CM6 amino acid regulated cytosolic protein G7083_00570 ENOG4105CRQ synthase (Component I) G7083_00575 ENOG4105P8F nudix hydrolase G7083_00580 ENOG4105C44 Serine transporter G7083_00585 ENOG4105EJQ L-serine dehydratase G7083_00590 ENOG4105DJY efflux transporter, rnd family, mfp subunit G7083_00595 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) G7083_00600 ENOG4105C5S asparaginyl-tRNA synthetase G7083_00605 ENOG4105CGF Aromatic amino acid aminotransferase G7083_00610 ENOG4105C8Q Methyl-accepting chemotaxis G7083_00615 ENOG4105DJ9 glucan biosynthesis protein G7083_00620 ENOG4105C3A Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity) G7083_00625 ENOG4105C5X domain protein G7083_00630 ENOG4105EAQ (twin-arginine translocation) pathway signal G7083_00635 ENOG4105DIT ErfK YbiS YcfS YnhG family protein G7083_00640 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) G7083_00650 ENOG4105S8Q sugar efflux transporter G7083_00660 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) G7083_00665 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) G7083_00670 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) G7083_00675 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) G7083_00710 ENOG4105FE9 pseudouridine synthase G7083_00715 ENOG4107RTD sua5 ycio yrdc ywlc family protein G7083_00720 ENOG4105DB7 PHP domain protein G7083_00730 ENOG4105CRQ synthase (Component I) G7083_00735 ENOG4105DDQ anthranilate synthase G7083_00740 ENOG4108I0Q anthranilate phosphoribosyltransferase G7083_00745 ENOG4105DK0 Indole-3-glycerol phosphate synthase G7083_00750 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) G7083_00755 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) G7083_00760 ENOG4105CK2 sodium dicarboxylate symporter G7083_00765 ENOG4107104 thymidine kinase G7083_00770 ENOG4105C9M aspartyl-trna synthetase G7083_00775 ENOG4105DA6 Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity) G7083_00780 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) G7083_00785 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) G7083_00805 ENOG4108ESU Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane (By similarity) G7083_00820 ENOG4108YZT Adenosylcobinamide kinase G7083_00825 ENOG4108UHF Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) G7083_00830 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) G7083_00835 ENOG4108ETY sodium dicarboxylate symporter G7083_00840 ENOG4105CJB Exodeoxyribonuclease I G7083_00845 ENOG4105VAW lrga family G7083_00850 ENOG41067MG lrgb family G7083_00870 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) G7083_00875 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) G7083_00880 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) G7083_00900 ENOG4105GR3 Histidine kinase G7083_00905 ENOG4105ETX regulatoR G7083_00940 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) G7083_00945 ENOG4105WH1 Two component transcriptional regulator luxr family G7083_00950 ENOG4105CQ2 DNA polymerase G7083_00960 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) G7083_00965 ENOG4108W5H UPF0263 protein G7083_00985 ENOG4105CQB FAD linked oxidase domain protein G7083_01015 ENOG4105C8V SAICAR synthetase G7083_01025 ENOG4107R1I NAD-dependent malic enzyme G7083_01035 ENOG4107GZ4 SanA protein G7083_01040 ENOG4105C3M thioredoxin reductase G7083_01045 ENOG4108JJ9 ABC, transporter G7083_01055 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) G7083_01065 ENOG4105CUX Signal transduction histidine kinase G7083_01090 ENOG4105DWU Membrane G7083_01095 ENOG4105DY8 decarboxylase G7083_01100 ENOG4106KNT transcriptional regulator G7083_01110 ENOG41090BQ Glutaredoxin G7083_01115 ENOG4105D0C transport protein G7083_01120 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit G7083_01125 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) G7083_01130 ENOG4105VEQ Cold shock protein G7083_01140 ENOG4108R99 pseudouridine synthase G7083_01145 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase G7083_01150 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) G7083_01155 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase G7083_01160 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) G7083_01165 ENOG4105ECC imidazole-glycerol-phosphate dehydratase G7083_01170 ENOG4105CIH Imidazole acetol-phosphate transaminase G7083_01175 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) G7083_01180 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) G7083_01185 ENOG4107S6Z Na H antiporter G7083_01195 ENOG4107RE1 Inosine-guanosine kinase G7083_01200 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) G7083_01205 ENOG41075W9 High frequency lysogenization protein HflD homolog G7083_01210 ENOG4107QTF adenylosuccinate lyase G7083_01220 ENOG4105RHG G7083_01230 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase G7083_01245 ENOG4107FW0 short-chain dehydrogenase reductase G7083_01255 ENOG41061MD high-affinity nickel-transporter G7083_01265 ENOG4105D0M Protease HtpX homolog G7083_01275 ENOG4105EWW Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) G7083_01280 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) G7083_01285 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) G7083_01290 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) G7083_01295 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) G7083_01300 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) G7083_01305 ENOG4105D1H recombination factor protein RarA G7083_01315 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving G7083_01320 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) G7083_01325 ENOG4108JJB ABC transporter G7083_01330 ENOG4105C7J ABC transporter, permease G7083_01340 ENOG4105VYA Uncharacterized conserved protein (DUF2132) G7083_01345 ENOG4105PQ6 UPF0208 membrane protein G7083_01350 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) G7083_01355 ENOG4108DNC Involved in acetate metabolism (By similarity) G7083_01360 ENOG4108JQ7 (ABC) transporter G7083_01365 ENOG4105C3U ABC transporter G7083_01370 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component G7083_01375 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component G7083_01380 ENOG4107QSI ABC, transporter G7083_01400 ENOG4105VEQ Cold shock protein G7083_01415 ENOG41082YX Transcriptional regulator, arsr family G7083_01425 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) G7083_01435 ENOG4105VNG YcgL domain-containing protein G7083_01440 ENOG4105K7U Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) G7083_01445 ENOG4107QMS site-determining protein G7083_01450 ENOG4105VJP Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity) G7083_01475 ENOG4107S74 Lysophospholipid transporter LplT G7083_01485 ENOG4105CEY Amp-dependent synthetase and ligase G7083_01495 ENOG4108IPT Naphthoate synthase G7083_01500 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) G7083_01505 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) G7083_01510 ENOG4105E4F Isochorismate synthase G7083_01515 ENOG4105CHM Aminotransferase G7083_01520 ENOG4105DK2 UPF0207 protein G7083_01525 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein G7083_01540 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) G7083_01545 ENOG4105CEY Amp-dependent synthetase and ligase G7083_01560 ENOG41072GX Peptidase M22 Glycoprotease G7083_01565 ENOG4105DVT helicase G7083_01575 ENOG4105CIY formyltetrahydrofolate deformylase G7083_01580 ENOG4105D07 Signal peptide peptidase, SppA G7083_01585 ENOG4105HDK L-asparaginase G7083_01595 ENOG4105E0X reductase G7083_01600 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase G7083_01605 ENOG4105DSB aldose 1-epimerase G7083_01615 ENOG4105DHI Methyltransferase G7083_01630 ENOG4105DAG ROK family G7083_01635 ENOG4108NRW Phospholipase, patatin family G7083_01650 ENOG4105C8J )-transporter G7083_01675 ENOG4105F8V Hydrolase, tatD family G7083_01680 ENOG4107QRG dna polymerase iii G7083_01685 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) G7083_01690 ENOG4105HHA aminodeoxychorismate lyase G7083_01695 ENOG4105YAZ 4-amino-4-deoxychorismate lyase G7083_01700 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) G7083_01705 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) G7083_01710 ENOG4105CHR reductase G7083_01715 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase G7083_01720 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) G7083_01725 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) G7083_01730 ENOG4105VGS 50s ribosomal protein l32 G7083_01735 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein G7083_01770 ENOG4108UHJ MAF-like protein G7083_01775 ENOG4105EI2 Pseudouridine synthase G7083_01780 ENOG4105C03 ribonuclease G7083_01790 ENOG4105C0A alcohol dehydrogenase G7083_01800 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein G7083_01805 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) G7083_01810 ENOG4105DFD Na H antiporter G7083_01815 ENOG4106V8H Nucleoid-associated protein G7083_01820 ENOG4105YDX UPF0352 protein G7083_01825 ENOG4105E68 Sulfatase G7083_01840 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) G7083_01845 ENOG4105M2J Glutaredoxin G7083_01850 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) G7083_01865 ENOG410903C (LipO)protein G7083_01870 ENOG4108M1T Cytochrome c-type biogenesis protein G7083_01875 ENOG4105KWW Biogenesis protein G7083_01880 ENOG4107QX9 Thiol disulfide interChange protein G7083_01885 ENOG4105DA4 cytochrome c-type biogenesis protein G7083_01890 ENOG4108ZKK Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity) G7083_01895 ENOG41067VX Heme exporter protein G7083_01900 ENOG41060IM Heme exporter protein G7083_01905 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) G7083_01910 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) G7083_01920 ENOG4108V3W Chemotaxis protein, CheW G7083_01930 ENOG4107QJE Chromosome Partitioning Protein G7083_01935 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) G7083_01945 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) G7083_01950 ENOG4108VYJ response regulator receiver protein G7083_01955 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) G7083_01965 ENOG4105FZW flagellar biosynthesis regulator FlhF G7083_01970 ENOG4105D7B Flagellar biosynthesis protein flha G7083_01975 ENOG4108BY2 phosphohistidine phosphatase G7083_01980 ENOG4108JQM Insulinase (Peptidase family M16) G7083_01990 ENOG4105C75 arginyL-tRNA synthetase G7083_02005 ENOG4105CE1 Ferrous iron transport protein b G7083_02010 ENOG4105XFK Ferrous iron transport protein A G7083_02015 ENOG4107S4Z Activates expression of the rhaBAD and rhaT operons (By similarity) G7083_02020 ENOG4105NXV High-affinity zinc uptake system protein G7083_02025 ENOG4105FDK ABC transporter G7083_02030 ENOG4105FAV ABC, transporter G7083_02035 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha G7083_02040 ENOG4105CMV Succinyl-CoA synthetase subunit beta G7083_02045 ENOG4105C7S Dehydrogenase G7083_02050 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 G7083_02060 ENOG4105BZN citrate synthase G7083_02065 ENOG4107QNR UPF0135 protein G7083_02070 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 G7083_02075 ENOG4107CDU Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity) G7083_02080 ENOG4105EV9 Alpha Beta Hydrolase G7083_02090 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) G7083_02095 ENOG41090R7 Ferric uptake G7083_02100 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) G7083_02105 ENOG4105CJ0 Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate (By similarity) G7083_02110 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) G7083_02115 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) G7083_02125 ENOG4105MH2 YfcL protein G7083_02130 ENOG4108BPE -transporting atpase G7083_02135 ENOG4105EN6 Membrane G7083_02140 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase G7083_02145 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) G7083_02150 ENOG4108DG9 Smr protein MutS2 G7083_02155 ENOG4105D00 flagellar biosynthetic protein flhB G7083_02160 ENOG4105D19 Role in flagellar biosynthesis (By similarity) G7083_02165 ENOG4105VS8 Flagellar biosynthetic protein fliq G7083_02170 ENOG4105CN7 Flagellar biosynthetic protein FliP G7083_02175 ENOG4105VTB flagellar biosynthesis protein fliO G7083_02180 ENOG4105DD5 Flagellar motor switch protein G7083_02185 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) G7083_02190 ENOG4105X6C Flagellar basal body-associated protein FliL G7083_02205 ENOG4108JIR Flagellum-specific ATP synthase G7083_02215 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) G7083_02220 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) G7083_02225 ENOG4105VQ0 flagellar hook-basal body complex protein fliE G7083_02235 ENOG4105BZU Histidine kinase G7083_02245 ENOG4105MQ3 flagellar protein FliS G7083_02255 ENOG4107W9T flagellar hook-associated G7083_02260 ENOG41063QE flagellar protein FlaG G7083_02265 ENOG4105I03 Flagellin G7083_02270 ENOG4105I03 Flagellin G7083_02275 ENOG4105EZR dyp-type peroxidase family protein G7083_02300 ENOG4105KUZ arsenate reductase G7083_02320 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) G7083_02335 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen G7083_02340 ENOG4105C8Q Methyl-accepting chemotaxis G7083_02355 ENOG4105ERG peptidase m48, ste24p G7083_02360 ENOG4105K89 arsenate reductase G7083_02370 ENOG4105C2W permease G7083_02375 ENOG4108Z66 YbaK ebsC protein G7083_02380 ENOG4105CGH 5'-nucleotidase G7083_02385 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase G7083_02390 ENOG41063JG Transcriptional regulator G7083_02395 ENOG4108YY7 Invasion gene expression up-regulator SirB G7083_02400 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) G7083_02405 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) G7083_02410 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) G7083_02415 ENOG4105C1U Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity) G7083_02420 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) G7083_02425 ENOG4105C5T Phosphoribosyl pyrophosphate synthase G7083_02430 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) G7083_02435 ENOG4105C3G gtp-binding protein G7083_02510 ENOG4105I03 Flagellin G7083_02515 ENOG4105I03 Flagellin G7083_02530 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj G7083_02535 ENOG4105D92 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) G7083_02540 ENOG4107W7W Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) G7083_02545 ENOG4105CGA flagellar basal-body rod protein FlgG G7083_02550 ENOG4108KPB Flagellar basal-body rod protein FlgF G7083_02555 ENOG4105BZE flagellar hook protein, FlgE G7083_02560 ENOG4105W00 Flagellar hook capping protein G7083_02565 ENOG4108ZC9 flagellar basal-body rod protein flgc G7083_02570 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) G7083_02575 ENOG4105BZU Histidine kinase G7083_02580 ENOG4107R88 Chemotaxis protein (CheV) G7083_02620 ENOG4105UYK outer membrane protein a G7083_02625 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) G7083_02640 ENOG4105E2D ec 3.2.1.52 G7083_02650 ENOG4105FE9 pseudouridine synthase G7083_02655 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) G7083_02660 ENOG4105CXB phosphoribosylaminoimidazole synthetase G7083_02665 ENOG4108V3E phosphoribosylglycinamide formyltransferase G7083_02670 ENOG4105E7A Glutamine amidotransferase G7083_02675 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) G7083_02685 ENOG4107RZZ dna polymerase iii epsilon subunit G7083_02690 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) G7083_02695 ENOG4105D1A Methyltransferase G7083_02700 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) G7083_02705 ENOG4105E9H Lytic Murein transglycosylase G7083_02710 ENOG4107NA1 Endonuclease Exonuclease phosphatase G7083_02715 ENOG4108YZA Nitrogen regulatory protein pii G7083_02720 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) G7083_02725 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) G7083_02730 ENOG4105C0B DNA polymerase III (alpha subunit) G7083_02735 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) G7083_02740 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) G7083_02745 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) G7083_02750 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) G7083_02755 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) G7083_02760 ENOG4108RFI Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity) G7083_02765 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane G7083_02770 ENOG4105DZP Membrane-associated zinc metalloprotease G7083_02775 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) G7083_02780 ENOG4105KNE Phosphatidate cytidylyltransferase G7083_02785 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) G7083_02790 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) G7083_02795 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) G7083_02800 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) G7083_02805 ENOG4105CE9 30S ribosomal protein S2 G7083_02810 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) G7083_02815 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) G7083_02820 ENOG4105C8Q Methyl-accepting chemotaxis G7083_02825 ENOG4108ZAI phosphatidylglycerophosphatase a G7083_02830 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) G7083_02835 ENOG4107YIM Involved in the transcription termination process (By similarity) G7083_02840 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) G7083_02855 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) G7083_02860 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) G7083_02865 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) G7083_02870 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) G7083_02875 ENOG4108UVK Binds to the sigma-S subunit of RNA polymerase, activating expression of sigma-S-regulated genes. Stimulates RNA polymerase holoenzyme formation and may bind to several other sigma factors, such as sigma-70 and sigma-32 (By similarity) G7083_02880 ENOG4108DJV Fermentation respiration switch protein G7083_02885 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) G7083_02890 ENOG4105C7N Xanthine uracil vitamin C permease G7083_02895 ENOG4105CIN aminoacyl-histidine dipeptidase G7083_02900 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) G7083_02905 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) G7083_02910 ENOG4105C8J )-transporter G7083_02920 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) G7083_02930 ENOG4105CJ2 (LipO)protein G7083_02935 ENOG4105D26 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway (By similarity) G7083_02940 ENOG4108IUB NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) G7083_02945 ENOG4105F5D NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) G7083_02950 ENOG4106I92 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) G7083_02955 ENOG4108J5C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) G7083_02960 ENOG4105DWQ NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) G7083_02965 ENOG4105M85 Bola protein G7083_02970 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) G7083_02980 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) G7083_02985 ENOG4105EYM Major Facilitator superfamily G7083_02990 ENOG4105DRB nucleoside-specific channel-forming protein G7083_02995 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) G7083_03000 ENOG4107S0N DJ-1 family G7083_03005 ENOG4105C9B Cysteine desulfurase G7083_03010 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) G7083_03015 ENOG4105CUZ uba thif-type nad fad binding protein G7083_03020 ENOG4105CA3 membrane-bound lytic murein transglycosylase G7083_03025 ENOG4107QZM n-acetylglutamate synthase G7083_03035 ENOG4107QYX exodeoxyribonuclease v alpha G7083_03040 ENOG4107QKA exodeoxyribonuclease V beta G7083_03045 ENOG4105DSY exodeoxyribonuclease V, gamma G7083_03055 ENOG4108M0I Transcriptional regulator G7083_03060 ENOG4105X2V dna damage-inducible protein G7083_03065 ENOG4105EJ3 Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA (By similarity) G7083_03070 ENOG4108R6G acetyltransferase G7083_03075 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) G7083_03090 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase G7083_03095 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) G7083_03100 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) G7083_03110 ENOG4105DTN riboflavin biosynthesis protein ribF G7083_03115 ENOG4105CJR Integral membrane protein (MviN G7083_03125 ENOG41063Z6 transcriptional regulator, lysR family G7083_03135 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) G7083_03140 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) G7083_03145 ENOG4105HF0 Membrane G7083_03150 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase G7083_03155 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) G7083_03160 ENOG4105IRT Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair (By similarity) G7083_03165 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family G7083_03170 ENOG4105CRK lysyL-tRNA synthetase G7083_03180 ENOG4105CWM branched-chain amino acid transport system II carrier protein G7083_03190 ENOG4105C1J atp-dependent rna helicase G7083_03200 ENOG4105BZU Histidine kinase G7083_03215 ENOG4108YYD acetyltransferase G7083_03225 ENOG4105BZU Histidine kinase G7083_03255 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) G7083_03260 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) G7083_03275 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) G7083_03280 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) G7083_03285 ENOG4105CHV Transcription elongation factor NusA G7083_03290 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) G7083_03305 ENOG4105NTZ Preprotein translocase subunit SecG G7083_03315 ENOG4105EEI dihydropteroate synthase G7083_03325 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) G7083_03330 ENOG4105HBR Rna-binding protein G7083_03335 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) G7083_03345 ENOG4105FCK Membrane G7083_03350 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase G7083_03355 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) G7083_03365 ENOG4108YX9 iron--sulfur cluster insertion protein erpA G7083_03370 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase G7083_03375 ENOG4105IPI Membrane G7083_03380 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) G7083_03385 ENOG4105BZU Histidine kinase G7083_03390 ENOG4107QRA Extracellular solute-binding protein, family 5 G7083_03400 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component G7083_03405 ENOG4105C3U ABC transporter G7083_03410 ENOG4108JQ7 (ABC) transporter G7083_03420 ENOG4105RD7 BadF BadG BcrA BcrD G7083_03425 ENOG4105E2D ec 3.2.1.52 G7083_03430 ENOG4105E2V Glycosyltransferase 36 G7083_03435 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) G7083_03440 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) G7083_03445 ENOG4105E0C molybdate abc transporter G7083_03460 ENOG4108YZA Nitrogen regulatory protein pii G7083_03465 ENOG4105XTV UPF0231 protein G7083_03480 ENOG4105BZ4 penicillin-binding protein G7083_03485 ENOG4105CQ7 ATP-dependent helicase G7083_03490 ENOG4105PW4 Sugar fermentation stimulation protein homolog G7083_03495 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters G7083_03500 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) G7083_03505 ENOG4105DJ0 Poly(A) Polymerase G7083_03510 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase G7083_03515 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) G7083_03520 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) G7083_03525 ENOG4105E3A (ABC) transporter G7083_03530 ENOG4105DA5 (ABC) transporter G7083_03535 ENOG41077A9 carbonic anhydrase G7083_03540 ENOG4108UGV hypoxanthine phosphoribosyltransferase G7083_03545 ENOG410630P Transcriptional regulator G7083_03550 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) G7083_03555 ENOG4105E1C Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a) (By similarity) G7083_03560 ENOG41082RQ UPF0102 protein G7083_03565 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) G7083_03570 ENOG4105W4M Transport-associated protein G7083_03575 ENOG4105KB2 stringent starvation protein b G7083_03580 ENOG4107MKT Stringent starvation protein a G7083_03585 ENOG4105EIX cytochrome c1 G7083_03590 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) G7083_03595 ENOG4108R5F Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) G7083_03600 ENOG4108UJD 30S ribosomal protein S9 G7083_03605 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) G7083_03615 ENOG4105C0H protease G7083_03620 ENOG4105C0H protease G7083_03625 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) G7083_03630 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) G7083_03635 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) G7083_03640 ENOG4105K5M 30s ribosomal protein S16 G7083_03645 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY G7083_03650 ENOG4106KVJ cytochrome C assembly protein G7083_03655 ENOG4108JU6 CBS domain protein G7083_03660 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) G7083_03665 ENOG4105D9M gamma-glutamylcysteine synthetase G7083_03675 ENOG4105W39 Membrane G7083_03685 ENOG4105D9Q decarboxylase (Beta subunit) G7083_03690 ENOG4107QSA Oxaloacetate decarboxylase G7083_03740 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) G7083_03750 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) G7083_03755 ENOG4105Y3E Modulates RecA activity (By similarity) G7083_03760 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) G7083_03765 ENOG4107TH8 cina domain protein G7083_03770 ENOG4108IJ6 ABC transporter G7083_03775 ENOG4105ECW sulfate abc transporter G7083_03780 ENOG4108I5D sulfate abc transporter G7083_03785 ENOG4108J2H Sulfate ABC transporter periplasmic sulfate-binding protein G7083_03790 ENOG4105C6T cysteine synthase G7083_03795 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) G7083_03800 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) G7083_03805 ENOG4108K5P (LipO)protein G7083_03810 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) G7083_03815 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) G7083_03820 ENOG4106NZV Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity) G7083_03825 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) G7083_03830 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) G7083_03840 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) G7083_03845 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase G7083_03850 ENOG4107ZVW dihydroneopterin aldolase G7083_03855 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) G7083_03865 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) G7083_03875 ENOG4105VCC 30S ribosomal protein S21 G7083_03880 ENOG4105KTH gatB Yqey G7083_03885 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) G7083_03890 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) G7083_03905 ENOG4105CAF HipA N-terminal domain protein G7083_03965 ENOG4107QTH restriction modification system DNA specificity domain G7083_04005 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) G7083_04010 ENOG410804X Transcriptional regulator G7083_04015 ENOG4105CA9 Pyruvate kinase G7083_04020 ENOG4105MPN Membrane G7083_04025 ENOG4105D64 Mechanosensitive ion channel G7083_04030 ENOG4105D2N Aldolase G7083_04035 ENOG4105BZA Phosphoglycerate kinase G7083_04040 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase G7083_04050 ENOG4105D05 Receptor G7083_04055 ENOG4108R4R Iron-regulated virulence regulatory protein G7083_04060 ENOG4105CV1 Transketolase (EC 2.2.1.1) G7083_04070 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP G7083_04080 ENOG4105RWS endonuclease I G7083_04085 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) G7083_04090 ENOG4105D7Z glutathione synthase G7083_04095 ENOG4108UJU UPF0301 protein G7083_04100 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) G7083_04105 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) G7083_04115 ENOG4105CZX twitching motility protein G7083_04120 ENOG4105CZX twitching motility protein G7083_04125 ENOG4105DFA alanine racemase domain protein G7083_04130 ENOG4105II7 pyrroline-5-carboxylate reductase G7083_04135 ENOG4108VIA integral membrane protein G7083_04145 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) G7083_04150 ENOG4105CSA Coproporphyrinogen iii oxidase G7083_04155 ENOG4105CSV Glutaminase G7083_04160 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) G7083_04165 ENOG4105CEN a g-specific adenine glycosylase G7083_04170 ENOG4105KMG Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity) G7083_04175 ENOG4106S48 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division G7083_04230 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) G7083_04235 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) G7083_04240 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) G7083_04245 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) G7083_04250 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) G7083_04255 ENOG4105NWN ApaG protein G7083_04260 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) G7083_04270 ENOG4107XM3 UPF0442 protein G7083_04275 ENOG4105DWK Membrane G7083_04280 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control G7083_04285 ENOG4105K46 50S ribosomal protein l27 G7083_04290 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) G7083_04295 ENOG4105EAH synthase G7083_04300 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) G7083_04305 ENOG410682Y Regulates arginine biosynthesis genes (By similarity) G7083_04340 ENOG41081QV Universal stress protein G7083_04360 ENOG4105D1U peptidase U62 modulator of DNA gyrase G7083_04370 ENOG4105QD6 exported protein G7083_04375 ENOG4105C03 ribonuclease G7083_04380 ENOG4108Z03 MAF-like protein G7083_04385 ENOG4105VQ7 Rod shape-determining protein MreD G7083_04390 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) G7083_04430 ENOG4105X0D Fimbrial protein G7083_04440 ENOG4105D7Q type ii secretion system G7083_04445 ENOG4107QHF type ii secretion system protein e G7083_04460 ENOG4105E4G Type IV pilus G7083_04480 ENOG41062P1 Diguanylate cyclase phosphodiesterase G7083_04485 ENOG4108UUM single-stranded DNA-binding protein G7083_04490 ENOG41086KC Transcriptional regulator G7083_04495 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase G7083_04500 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) G7083_04510 ENOG4105CFH Aspartokinase G7083_04515 ENOG4105C3R Methionine synthase G7083_04520 ENOG4105EEQ Na H antiporter G7083_04605 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) G7083_04615 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) G7083_04625 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) G7083_04630 ENOG4105MYN Zinc uptake regulation protein G7083_04640 ENOG4107QP8 phosphohexose isomerase G7083_04645 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) G7083_04650 ENOG4105CDU Replicative dna helicase G7083_04660 ENOG4105K9Q Binds to the 23S rRNA (By similarity) G7083_04665 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) G7083_04670 ENOG4108VDV Binds single-stranded DNA at the primosome assembly site (PAS) (By similarity) G7083_04675 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) G7083_04680 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) G7083_04685 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) G7083_04690 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) G7083_04705 ENOG4108ZKU Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) G7083_04710 ENOG4108ZAT Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity) G7083_04715 ENOG4105WWK YheO domain protein G7083_04720 ENOG4108V1T peptidylprolyl cis-trans isomerase G7083_04730 ENOG41069P5 Protein slyX homolog G7083_04740 ENOG4105EPW hflc protein G7083_04745 ENOG4107QJR hflk protein G7083_04750 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) G7083_04755 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) G7083_04760 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) G7083_04765 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) G7083_04770 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase G7083_04775 ENOG4105K8N protein family UPF0079, ATPase G7083_04780 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) G7083_04835 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) G7083_04840 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) G7083_04845 ENOG4105DJ4 phosphatidylserine decarboxylase G7083_04850 ENOG4105C8P )-transporter G7083_04860 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) G7083_04865 ENOG41063SB peptidase G7083_04880 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) G7083_04885 ENOG4105E09 nadh pyrophosphatase G7083_04895 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) G7083_04900 ENOG4107QIH DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) G7083_04905 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) G7083_04910 ENOG4108VZM 50s ribosomal protein L10 G7083_04920 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) G7083_04925 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) G7083_04930 ENOG4105PM1 preprotein translocase subunit SecE G7083_04935 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) G7083_04960 ENOG4105CS9 pantothenic acid kinase G7083_04965 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase G7083_04970 ENOG4105D4A Cell wall formation (By similarity) G7083_04980 ENOG4105JIM Phosphatidylserine synthase G7083_05015 ENOG4107QK7 reductase G7083_05025 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) G7083_05030 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) G7083_05040 ENOG4105C1J atp-dependent rna helicase G7083_05045 ENOG4105C9X ppx gppa phosphatase G7083_05050 ENOG4105D8G Major Facilitator superfamily G7083_05055 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) G7083_05060 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein G7083_05065 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase G7083_05070 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) G7083_05075 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) G7083_05080 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) G7083_05090 ENOG4105R2J Conserved Protein G7083_05095 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase G7083_05100 ENOG4105CUY Mechanosensitive ion channel G7083_05105 ENOG4105DIQ Transcriptional regulator G7083_05110 ENOG4105C01 Dihydroxy-acid dehydratase G7083_05115 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family G7083_05120 ENOG4105C6Z Gluconate G7083_05125 ENOG4108UHU Aldolase G7083_05140 ENOG4105EIP mannose-6-phosphate isomerase G7083_05145 ENOG4105DM4 PTS System G7083_05150 ENOG4106R3P AraC family transcriptional regulator G7083_05160 ENOG4108YRF PTS System G7083_05165 ENOG4105DM4 PTS System G7083_05170 ENOG4105DM4 PTS System G7083_05175 ENOG4105DM4 PTS System G7083_05180 ENOG4105W1Y Transcriptional regulator G7083_05195 ENOG4105C12 Phosphoribosylglycinamide synthetase G7083_05235 ENOG4105M0J Toxic component of a toxin-antitoxin (TA) module. A G7083_05245 ENOG4105K70 DNA-binding protein G7083_05250 ENOG4105CDV Ompa motb domain protein G7083_05380 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase G7083_05390 ENOG4105D3Q Sugar transferase G7083_05410 ENOG4108UW5 maltose o-acetyltransferase G7083_05425 ENOG4108IJ1 Dehydrogenase G7083_05430 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase G7083_05435 ENOG410600T transposase G7083_05440 ENOG4108KPN Confers a modal distribution of chain length on the O- antigen component of lipopolysaccharide (LPS). Gives rise to a reduced number of short chain molecules and increases in numbers of longer molecules, with a modal value of 13 (in strain O111 M92) and of 17 (in strain K12) G7083_05445 ENOG4105CY0 Metallo-Beta-Lactamase G7083_05450 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) G7083_05475 ENOG4105XA0 heptosyltransferase ii G7083_05480 ENOG4108ST3 glycosyltransferase G7083_05485 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase G7083_05515 ENOG4105EXC Acyl-transferase G7083_05520 ENOG4108W7E Catalyzes the ATP-dependent phosphorylation of the 3- deoxy-D-manno-octulosonic acid (Kdo) residue in Kdo-lipid IV(A) at the 4-OH position (By similarity) G7083_05525 ENOG4105DKP glycosyl transferase, family 9 G7083_05530 ENOG4106WTF Glycosyl transferase, family 2 G7083_05535 ENOG4105M5K heptosyltransferase G7083_05540 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) G7083_05545 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) G7083_05555 ENOG4105W0E 50S ribosomal protein L33 G7083_05560 ENOG4105KDC 50s ribosomal protein l28 G7083_05565 ENOG4105W5Q DNA repair protein (RadC G7083_05570 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase G7083_05575 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) G7083_05580 ENOG4105D1S lipid A biosynthesis G7083_05585 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase G7083_05590 ENOG4107QP2 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) G7083_05595 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) G7083_05600 ENOG4105DSJ YicC domain protein G7083_05620 ENOG4105DU6 RNA polymerase G7083_05635 ENOG4105BZ1 (ABC) transporter G7083_05635 ENOG4105BZ1 (ABC) transporter G7083_05640 ENOG4105C9U ATP-dependent DNA helicase RecQ G7083_05645 ENOG4105FR1 rard protein G7083_05650 ENOG4105C4R Atp-dependent dna helicase G7083_05655 ENOG4105DGW oligopeptidase A G7083_05660 ENOG4105D6S protein involved in catabolism of external DNA G7083_05665 ENOG4105DC8 reductase G7083_05760 ENOG41072JS exoenzyme T G7083_05770 ENOG4105CCD The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) G7083_05780 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component G7083_05785 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component G7083_05825 ENOG4105MPD Cytochrome G7083_05830 ENOG4105C4R Atp-dependent dna helicase G7083_05835 ENOG410624X efflux transporter, rnd family, mfp subunit G7083_05840 ENOG4105BZS acriflavin resistance protein G7083_05845 ENOG4105W0Z cytoplasmic protein G7083_05850 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase G7083_05855 ENOG4105EMY transcriptional regulator G7083_05915 ENOG4108Z0R Transferase G7083_05925 ENOG4105E2X shikimate dehydrogenase G7083_05935 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) G7083_05940 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) G7083_05945 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit G7083_05950 ENOG4108WI1 Dna topoisomerase G7083_05955 ENOG4108RPN Protein smg homolog G7083_05960 ENOG4105C79 DNA protecting protein DprA G7083_05965 ENOG4108WZM domain protein G7083_05980 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B G7083_05985 ENOG4105C1A potassium transporter peripheral membrane G7083_05990 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) G7083_05995 ENOG4108UT2 hemolysin iii G7083_06000 ENOG4105PC1 Conserved Protein G7083_06005 ENOG4105C58 cytochrome c oxidase accessory protein ccog G7083_06010 ENOG4105E27 serine threonine protein kinase G7083_06015 ENOG4108Z33 Thiol disulfide Interchange Protein G7083_06020 ENOG4105C0P Mg chelatase subunit ChlI G7083_06040 ENOG4105C01 Dihydroxy-acid dehydratase G7083_06045 ENOG4105C7B Threonine dehydratase G7083_06050 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family G7083_06055 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) G7083_06070 ENOG4107QIB glycyl-tRNA synthetase, alpha subunit G7083_06075 ENOG4105C38 Glycyl-tRNA synthetase beta subunit G7083_06080 ENOG4105JKW Valine--pyruvate aminotransferase G7083_06085 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) G7083_06090 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) G7083_06095 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) G7083_06100 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) G7083_06110 ENOG4105NVJ RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) G7083_06120 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins G7083_06125 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) G7083_06130 ENOG4105QTB Flavodoxin G7083_06135 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) G7083_06140 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) G7083_06145 ENOG4107QJE Chromosome Partitioning Protein G7083_06150 ENOG4105FA0 parb-like partition protein G7083_06155 ENOG410684E atp synthase G7083_06160 ENOG4105EE4 it plays a direct role in the translocation of protons across the membrane (By similarity) G7083_06170 ENOG4107Z6K F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) G7083_06175 ENOG4107S15 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) G7083_06180 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) G7083_06185 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) G7083_06190 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) G7083_06195 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) G7083_06200 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) G7083_06205 ENOG4105CZQ inner membrane transport protein YdhC G7083_06210 ENOG4105F52 Transcriptional regulator G7083_06215 ENOG4105CHU acetyl-coa acetyltransferase G7083_06225 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein G7083_06230 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) G7083_06235 ENOG4108RR8 protoporphyrinogen oxidase G7083_06355 ENOG4105WMR Protein CrcB homolog G7083_06370 ENOG4108VVK transcriptional Regulator, AsnC G7083_06385 ENOG4105EMK carboxylate amino acid amine transporter G7083_06390 ENOG4108M6U Universal stress protein A G7083_06395 ENOG41090A1 ferritin G7083_06400 ENOG4108V6B universal stress protein B G7083_06405 ENOG4105CBX hi0933 family G7083_06410 ENOG4105CGY Dna recombination protein G7083_06415 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) G7083_06420 ENOG4105JC1 sterol-binding domain protein G7083_06430 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) G7083_06435 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) G7083_06440 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) G7083_06445 ENOG4107R73 Mate efflux family protein G7083_06450 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) G7083_06455 ENOG4105E55 glycerol-3-phosphate acyltransferase G7083_06460 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) G7083_06465 ENOG4105VEI Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity) G7083_06470 ENOG4105X6C Flagellar basal body-associated protein FliL G7083_06480 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) G7083_06490 ENOG4105D52 delta-aminolevulinic acid dehydratase G7083_06500 ENOG4105C2M dna polymerase I G7083_06510 ENOG4106RE7 Cytochrome G7083_06520 ENOG4105ZR3 A GTPase-activating protein (GAP) that modifies Der EngA GTPase function. May play a role in ribosome biogenesis (By similarity) G7083_06525 ENOG4105XCT Protein of unknown function (DUF2489) G7083_06530 ENOG4105D4P Coproporphyrinogen iii oxidase G7083_06535 ENOG410601J HemY protein G7083_06540 ENOG4105ECF c-methyltransferase G7083_06545 ENOG41076E6 Uroporphyrinogen-III Synthase G7083_06550 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) G7083_06555 ENOG4107T0K Adenylate cyclase G7083_06560 ENOG4105XQ6 frataxin-like protein G7083_06570 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) G7083_06575 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) G7083_06580 ENOG4105CT0 Protein of unknown function, DUF484 G7083_06585 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) G7083_06590 ENOG4105BZU Histidine kinase G7083_06600 ENOG4105DQF Hydrolase G7083_06605 ENOG4108EUD Lysophospholipase G7083_06610 ENOG410829K Lysine exporter protein (Lyse ygga) G7083_06615 ENOG4105D58 Diguanylate phosphodiesterase G7083_06620 ENOG4108RMU ferritin dps family protein G7083_06640 ENOG4106H78 methyltransferase G7083_06645 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) G7083_06650 ENOG4105CAK Cell division ATP-binding protein ftsE G7083_06655 ENOG4105CRP Part of the ABC transporter FtsEX involved in G7083_06660 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) G7083_06690 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) G7083_06695 ENOG4105EMU Dehydrogenase G7083_06700 ENOG4107R9T Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNAs (By similarity) G7083_06705 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) G7083_06715 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) G7083_06800 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) G7083_06805 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family G7083_06810 ENOG4105CUX Signal transduction histidine kinase G7083_06820 ENOG4105C5F glutamine synthetase G7083_06825 ENOG4105CI3 gtp-binding protein typa G7083_06835 ENOG4107S2Z UPF0761 membrane protein G7083_06840 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) G7083_06845 ENOG4105SUU thioesterase domain G7083_06855 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase G7083_06860 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) G7083_06865 ENOG4105VEJ Heat shock protein G7083_06870 ENOG4108XKW General secretion pathway protein C G7083_06880 ENOG4107QHF type ii secretion system protein e G7083_06885 ENOG4105D7Q type ii secretion system G7083_06890 ENOG4108VAU general secretion pathway protein G G7083_06895 ENOG4105VWV general secretion pathway protein h G7083_06900 ENOG4105X5Z General secretion pathway protein I G7083_06905 ENOG4108WWZ General secretion pathway protein J G7083_06910 ENOG4108RTD type II secretion system protein K G7083_06915 ENOG4108BY5 Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins (By similarity) G7083_06920 ENOG4105U1E general secretion pathway protein M G7083_06925 ENOG4105PIC general secretion pathway protein N G7083_06930 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase G7083_06935 ENOG4107RK2 ADP-ribose diphosphatase NudE G7083_06945 ENOG4105MJ2 Competence protein G7083_06950 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) G7083_06960 ENOG4105BZM domain protein G7083_06965 ENOG4108RRZ Transcription elongation factor GreB G7083_06980 ENOG4105E0F Histidine kinase G7083_06985 ENOG4105C2W permease G7083_06990 ENOG4105CB5 ATP-dependent DNA helicase recG G7083_06995 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) G7083_07005 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) G7083_07010 ENOG4105EX9 Membrane G7083_07020 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) G7083_07030 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter G7083_07035 ENOG4108IJ0 Aspartate ammonia-lyase G7083_07045 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) G7083_07050 ENOG4105E0F Histidine kinase G7083_07055 ENOG4105E3W Two component transcriptional regulator (Winged helix family G7083_07065 ENOG41076HS cation diffusion facilitator family transporter G7083_07070 ENOG4105CTQ phosphohexokinase G7083_07075 ENOG4105CBT Fructose-1,6-bisphosphatase G7083_07085 ENOG4105SYT Methylenetetrahydrofolate reductase G7083_07090 ENOG4105CFH Aspartokinase G7083_07095 ENOG4105C28 cystathionine G7083_07100 ENOG4105GGQ This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis (By similarity) G7083_07105 ENOG4105C6K Malic enzyme G7083_07110 ENOG4105VFB Binds the 23S rRNA (By similarity) G7083_07115 ENOG4105C25 Primosomal protein n' G7083_07205 ENOG4108RBT type iii secretion G7083_07230 ENOG4108HR8 type iii secretion G7083_07240 ENOG4108JIR Flagellum-specific ATP synthase G7083_07260 ENOG41075IY surface presentation of antigens protein SpaP G7083_07265 ENOG4105U07 type iii secretion G7083_07270 ENOG4108TN6 type iii secretion G7083_07290 ENOG4108M6W surface presentation of antigens protein SpaS G7083_07300 ENOG4105ER2 Ompa motb domain protein G7083_07305 ENOG4107VGF ig domain protein group 2 domain protein G7083_07330 ENOG4105DU6 RNA polymerase G7083_07340 ENOG4105C8Q Methyl-accepting chemotaxis G7083_07390 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) G7083_07395 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) G7083_07400 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase G7083_07405 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) G7083_07415 ENOG4105CP7 Triose-phosphate isomerase G7083_07440 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) G7083_07445 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) G7083_07455 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein G7083_07460 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) G7083_07470 ENOG4108WJH Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) G7083_07475 ENOG4105E33 succinate dehydrogenase G7083_07485 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) G7083_07490 ENOG4107YZP Rhodanese domain protein G7083_07495 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) G7083_07500 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase G7083_07505 ENOG4105D7W serine acetyltransferase G7083_07510 ENOG4105U3E Transcriptional regulator G7083_07515 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) G7083_07520 ENOG4105CWC Acetylornithine deacetylase G7083_07525 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase G7083_07530 ENOG4105CAS nag kinase G7083_07535 ENOG4105CDH Citrulline--aspartate ligase G7083_07550 ENOG4107QN2 dihydrolipoyl dehydrogenase G7083_07555 ENOG4105EHV domain protein G7083_07565 ENOG4108JQC penicillin-binding protein 1A G7083_07590 ENOG4105E4G Type IV pilus G7083_07595 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) G7083_07600 ENOG4105D49 3-dehydroquinate synthase G7083_07610 ENOG4105DFE Dna adenine methylase G7083_07615 ENOG4105DJV ribulose-phosphate 3-epimerase G7083_07620 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) G7083_07625 ENOG4105C31 Tryptophanyl-tRNA synthetase G7083_07630 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) G7083_07635 ENOG4105DDQ anthranilate synthase G7083_07640 ENOG4105C8Y Acetylornithine aminotransferase G7083_07645 ENOG4107RYR Transcriptional regulator, Crp Fnr family G7083_07650 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) G7083_07660 ENOG4105C5H ABC transporter G7083_07665 ENOG4108YZY peptidylprolyl cis-trans isomerase G7083_07670 ENOG4105D44 asparaginase G7083_07675 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis G7083_07680 ENOG4108UV7 flagellar protein motX G7083_07685 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) G7083_07690 ENOG4105C2N RNA methyltransferase TrmH family group 3 G7083_07695 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) G7083_07700 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) G7083_07705 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) G7083_07710 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) G7083_07720 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) G7083_07725 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) G7083_07730 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) G7083_07735 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) G7083_07740 ENOG41083MP 50s ribosomal protein l29 G7083_07750 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) G7083_07755 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) G7083_07760 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits G7083_07765 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) G7083_07770 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) G7083_07775 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) G7083_07780 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) G7083_07785 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) G7083_07790 ENOG4105VPB 50S ribosomal protein L30 G7083_07800 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) G7083_07810 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits G7083_07815 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) G7083_07820 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) G7083_07825 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) G7083_07830 ENOG4108ZT0 50S ribosomal protein l17 G7083_07835 ENOG4108V1T peptidylprolyl cis-trans isomerase G7083_07840 ENOG4105FHY Opacity-associated protein A G7083_07850 ENOG4105C1J atp-dependent rna helicase G7083_07855 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) G7083_07860 ENOG4105C11 sulfate adenylyltransferase), subunit 2 G7083_07865 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) G7083_07870 ENOG4107UCJ Catalyzes the synthesis of activated sulfate (By similarity) G7083_07890 ENOG4107R39 (ABC) transporter G7083_07905 ENOG4108UUE Transcriptional regulator G7083_07910 ENOG4105CFU surface antigen G7083_07920 ENOG41066HZ AIG2-like family G7083_07925 ENOG4105F0N pyrophosphate phospho-hydrolase G7083_07935 ENOG4105DFU Cell wall formation (By similarity) G7083_07940 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase G7083_07955 ENOG4107T0D ABC, transporter G7083_07960 ENOG4105N42 UPF0307 protein G7083_07965 ENOG4105CMS peptidase U62, modulator of DNA gyrase G7083_07970 ENOG4105CJW magnesium transporter G7083_07975 ENOG41080Z8 PHOSPHOCARRIER protein G7083_07980 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) G7083_07985 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN G7083_07990 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA G7083_07995 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) G7083_08000 ENOG4108IUZ ABC transporter G7083_08005 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA G7083_08010 ENOG4108P1K Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane (By similarity) G7083_08015 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase G7083_08020 ENOG4105C2X Arabinose 5-phosphate isomerase G7083_08030 ENOG4105DHJ ABC, transporter G7083_08035 ENOG4105CY3 ABC transporter, permease G7083_08040 ENOG4107PE3 Mammalian cell entry related domain protein G7083_08045 ENOG4105E3I toluene tolerance G7083_08055 ENOG4105VFK BolA family G7083_08060 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) G7083_08065 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase G7083_08070 ENOG4105KME endoribonuclease L-psp G7083_08075 ENOG4108R9M Involved in allosteric regulation of aspartate carbamoyltransferase (By similarity) G7083_08080 ENOG4105CXT aspartate transcarbamylase G7083_08090 ENOG4108IAB Phoh family G7083_08105 ENOG4105K3M )-transporter G7083_08110 ENOG4105D3G Pseudouridine synthase G7083_08115 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) G7083_08120 ENOG4105MYG DNA polymerase iii, chi subunit G7083_08125 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) G7083_08130 ENOG4108M8S permease YjgP YjgQ family protein G7083_08135 ENOG4108K5H permease YjgP YjgQ family protein G7083_08200 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) G7083_08205 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) G7083_08210 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) G7083_08220 ENOG410841Q phosphoesterase PA-phosphatase related protein G7083_08230 ENOG41064T2 transcriptional regulator, lysR family G7083_08235 ENOG4108IQE Amp-dependent synthetase and ligase G7083_08240 ENOG4105C7K acetolactate synthase G7083_08245 ENOG4108ZP8 Acetolactate synthase small subunit G7083_08250 ENOG4108JQ1 Dehydrogenase G7083_08255 ENOG4105E66 phosphoriboisomerase A G7083_08260 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase G7083_08270 ENOG4107YUN Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) G7083_08280 ENOG4105D0A hydroxylase G7083_08285 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family G7083_08300 ENOG4105Y75 tpr repeat protein G7083_08310 ENOG4108IYU L-aspartate oxidase G7083_08315 ENOG4105EMN RNA polymerase sigma factor G7083_08320 ENOG41069PW sigma-e factor negative regulatory protein G7083_08330 ENOG4105WMJ Positive regulator of sigma E, RseC MucC G7083_08335 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) G7083_08340 ENOG4105C3F Signal peptidase i G7083_08345 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) G7083_08350 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) G7083_08355 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) G7083_08360 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) G7083_08365 ENOG4105KJV Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) G7083_08370 ENOG4105BZU Histidine kinase G7083_08375 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) G7083_08380 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) G7083_08385 ENOG4105DXN mazG family G7083_08390 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) G7083_08395 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) G7083_08400 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate G7083_08415 ENOG4106MWK domain protein G7083_08420 ENOG4105CJ3 phosphate transporter G7083_08425 ENOG4107IX6 phosphate transport regulator G7083_08430 ENOG4105I7R Adenylate cyclase G7083_08435 ENOG4108NVR Methyl-accepting chemotaxis G7083_08440 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) G7083_08445 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) G7083_08450 ENOG4105DFG type I secretion outer membrane protein G7083_08455 ENOG41087AY ADP-Ribose pyrophosphatase G7083_08460 ENOG4108SX3 cytoplasmic protein G7083_08465 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) G7083_08470 ENOG4105IPS esterase G7083_08475 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) G7083_08480 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) G7083_08490 ENOG4105DHA Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity (By similarity) G7083_08495 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) G7083_08500 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) G7083_08505 ENOG4105D7Q type ii secretion system G7083_08510 ENOG4107QHF type ii secretion system protein e G7083_08515 ENOG4105KHS type IV fimbrial pilin protein G7083_08520 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase G7083_08530 ENOG41071R3 Low-potential electron donor to a number of redox enzymes (By similarity) G7083_08535 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) G7083_08540 ENOG4105T95 Thiol disulfide interChange protein G7083_08545 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) G7083_08550 ENOG41073TP transcriptional regulator G7083_08555 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) G7083_08560 ENOG4107QSN dihydrolipoamide acetyltransferase G7083_08565 ENOG4107QN2 dihydrolipoyl dehydrogenase G7083_08580 ENOG41063Y6 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) G7083_08585 ENOG4105CJN penicillin-binding protein G7083_08590 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) G7083_08595 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) G7083_08605 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) G7083_08615 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) G7083_08620 ENOG4105DFU Cell wall formation (By similarity) G7083_08625 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) G7083_08630 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) G7083_08635 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) G7083_08640 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) G7083_08650 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving G7083_08655 ENOG4105M6F mutator MutT protein G7083_08660 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) G7083_08665 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain G7083_08670 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain G7083_08675 ENOG4105EJ9 Membrane G7083_08680 ENOG4105EN6 Membrane G7083_08685 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) G7083_08695 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) G7083_08710 ENOG4105N5T Radical SAM Protein G7083_08715 ENOG4105BZU Histidine kinase G7083_08720 ENOG41065U4 response regulator G7083_08725 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) G7083_08740 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) G7083_08745 ENOG4105D98 threonine synthase G7083_08750 ENOG4108VKA Acts as a radical domain for damaged PFL and possibly other radical proteins (By similarity) G7083_08755 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) G7083_08760 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) G7083_08775 ENOG4105BZG amino acid carrier protein G7083_08780 ENOG4105D1Q UPF0246 protein G7083_08785 ENOG4105EYA deoxyribonuclease G7083_08790 ENOG4105D9N nucleoside G7083_08795 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) G7083_08800 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) G7083_08805 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) G7083_08810 ENOG4105D3A purine nucleoside phosphorylase DeoD-type G7083_08820 ENOG4105EAC phosphoserine phosphatase G7083_08830 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) G7083_08835 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) G7083_08840 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate G7083_08845 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) G7083_08855 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) G7083_08860 ENOG4105EHE chorismate mutase- prephenate dehydrogenase G7083_08870 ENOG4105C5H ABC transporter G7083_08875 ENOG4107SC1 transglycosylase G7083_08880 ENOG4105R9M This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region (By similarity) G7083_08890 ENOG4108K0B C-di-gmp phosphodiesterase G7083_08895 ENOG4107XW0 Spermidine putrescine ABC transporter periplasmic spermidine putrescine-binding protein G7083_08905 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA G7083_08910 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane G7083_08915 ENOG4105C34 Pseudouridine synthase G7083_08920 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase G7083_08925 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit G7083_09015 ENOG41064RH membrane protein YliF G7083_09025 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding G7083_09030 ENOG4105CFP Peptidase U32 G7083_09040 ENOG4105CK6 Two component transcriptional regulator (Winged helix family G7083_09045 ENOG4105BZU Histidine kinase G7083_09050 ENOG4105DJH phosphate G7083_09055 ENOG4105C9X ppx gppa phosphatase G7083_09060 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) G7083_09065 ENOG4105C8U phosphate abc transporter G7083_09070 ENOG4105E2Z phosphate ABC transporter (Permease G7083_09075 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) G7083_09085 ENOG4105CSR polyphosphate kinase 2 G7083_09090 ENOG4106N3A copper homeostasis protein cutc G7083_09095 ENOG4105D3R alkyl hydroperoxide reductase G7083_09100 ENOG4105C5Q Transcriptional regulator G7083_09105 ENOG4105W87 Cbs domain G7083_09110 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) G7083_09120 ENOG4105VIE preprotein translocase, subunit YajC G7083_09125 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) G7083_09130 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) G7083_09135 ENOG4105ECY inositol monophosphatase G7083_09140 ENOG4105CVS RNA methyltransferase TrmH family, group 1 G7083_09145 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family G7083_09155 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins G7083_09160 ENOG4108Z4V iron-sulfur cluster assembly G7083_09165 ENOG4108SWN Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity) G7083_09175 ENOG4108ZIT Ferredoxin, 2FE-2S G7083_09180 ENOG4105WVQ Fe-S assembly protein IscX G7083_09185 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) G7083_09190 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) G7083_09205 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) G7083_09210 ENOG4105CUT histidyl-tRNA synthetase G7083_09215 ENOG4105N21 Membrane G7083_09220 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) G7083_09225 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) G7083_09240 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) G7083_09245 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) G7083_09250 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) G7083_09255 ENOG4106HK8 GPR1 FUN34 yaaH family protein G7083_09260 ENOG4105BZG amino acid carrier protein G7083_09275 ENOG4108Z4U Ferredoxin G7083_09280 ENOG4105DZ0 fad dependent oxidoreductase G7083_09315 ENOG4105BZU Histidine kinase G7083_09410 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) G7083_09415 ENOG4108Z1B Cyclase dehydrase G7083_09420 ENOG4105VDB UPF0125 protein G7083_09425 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) G7083_09430 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) G7083_09435 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) G7083_09440 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ G7083_09445 ENOG4105CFG Acts as a chaperone (By similarity) G7083_09450 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) G7083_09480 ENOG4105CFC Transporter G7083_09485 ENOG4108Z6B deaminase G7083_09490 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) G7083_09500 ENOG4107QIK phosphoribosylformylglycinamidine synthase G7083_09515 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) G7083_09520 ENOG4108R96 Methyltransferase, YaeB family G7083_09525 ENOG4108UPT UPF0178 protein G7083_09540 ENOG4105WP7 tRNA pseudouridine synthase C G7083_09545 ENOG4105DR9 pseudouridine synthase G7083_09550 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) G7083_09555 ENOG4105CTB Polyprenyl synthetase G7083_09565 ENOG4105E14 MotA TolQ exbB proton channel G7083_09570 ENOG4107XSU flagellar motor protein motb G7083_09570 ENOG4107XSU flagellar motor protein motb G7083_09575 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) G7083_09580 ENOG4105ETT transcriptional Regulator, LysR family G7083_09585 ENOG4105CIQ May have a role in processing of nucleic acids. It is probably not an exonuclease G7083_09590 ENOG4105EWT decarboxylase family G7083_09595 ENOG4105FSR swimming returnes to normal when residues 206-207 are both mutated to Ala. Overexpression also leads to a reduction in flagellar abundance and a 20-fold increase in c-di- GMP levels in vivo. Required for aminoglycoside-mediated induction of biofilm formation, it also plays a lesser role in biofilm production in response to other classes of translation inhibitors. The c-di-GMP produced by this enzyme up-regulates poly-GlcNAc production as well as the biofilm synthesis protein PgaD, although c-di-GMP is probably not the main inducing principle. Cyclic-di- GMP is a second messenger which controls cell surface-associated traits in bacteria G7083_09605 ENOG4107R1K Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) G7083_09610 ENOG4108T6E Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function (By similarity) G7083_09615 ENOG4105EXF Zn-ribbon-containing, possibly nucleic-acid-binding protein G7083_09620 ENOG4105D01 (LipO)protein G7083_09625 ENOG4108UMI ABC transporter, permease G7083_09630 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) G7083_09635 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase G7083_09660 ENOG410624X efflux transporter, rnd family, mfp subunit G7083_09665 ENOG4105BZS acriflavin resistance protein G7083_09670 ENOG4105KJF protein tyrosine phosphatase G7083_09675 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase G7083_09735 ENOG4105D3Q Sugar transferase G7083_09745 ENOG4105DAY polysaccharide export protein G7083_09760 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) G7083_09765 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) G7083_09770 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) G7083_09775 ENOG4108Z43 UPF0250 protein G7083_09780 ENOG4105DZ1 carboxypeptidase G7083_09785 ENOG4105K6T rare lipoprotein A G7083_09790 ENOG4105CNI cell division protein FtsW G7083_09795 ENOG4105CJN penicillin-binding protein G7083_09800 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) G7083_09805 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) G7083_09810 ENOG4105DJF DNA polymerase III, delta' subunit G7083_09815 ENOG4108U2H Rare lipoprotein B G7083_09820 ENOG4105C8T Leucyl-tRNA synthetase G7083_09825 ENOG4107PAI alpha helical protein G7083_09830 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) G7083_09835 ENOG4108JU5 Magnesium and cobalt efflux protein G7083_09845 ENOG4105C9A Phoh family G7083_09850 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) G7083_09855 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family G7083_09865 ENOG4105C5Y PTS System G7083_09870 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) G7083_09875 ENOG4105KZ7 phosphocarrier protein hpr G7083_09880 ENOG4105C6T cysteine synthase G7083_09885 ENOG4105EXN Sulfate transport protein CysZ G7083_09890 ENOG4107NPY receptor for the septal ring structure, may anchor it to the inner-membrane (By similarity) G7083_09895 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) G7083_09900 ENOG41081QG Porin Gram-negative type G7083_09910 ENOG4108Z6Z Transcriptional regulator G7083_09920 ENOG4107QX8 SPFH domain, Band 7 family protein G7083_09925 ENOG4107QR8 Thioredoxin G7083_09930 ENOG4105ECP epimerase G7083_09940 ENOG4108TU9 TRANSCRIPTIONal G7083_09945 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) G7083_09950 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) G7083_09955 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) G7083_09960 ENOG4105MDZ Transcriptional activator rfaH G7083_09965 ENOG4105CAQ asparagine synthetase G7083_09970 ENOG4105CKD glutathione-regulated potassium-efflux system protein G7083_09975 ENOG4105E2R ROK family G7083_09980 ENOG4105CE4 GlcNAc 6-P deacetylase G7083_09985 ENOG4105CI1 PTS System G7083_10000 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) G7083_10010 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase G7083_10015 ENOG4108S3P Sporulation domain protein G7083_10020 ENOG4105E96 Colicin v production protein G7083_10025 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase G7083_10030 ENOG4105D3Y Na H antiporter G7083_10035 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) G7083_10040 ENOG4105EIY sodium-type flagellar protein motY G7083_10045 ENOG4108UYE Lactoylglutathione lyase G7083_10050 ENOG4105CSM endonuclease III G7083_10055 ENOG4105DZB Electron transport complex G7083_10075 ENOG4108R3D Electron transport complex G7083_10085 ENOG4105C8Q Methyl-accepting chemotaxis G7083_10095 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) G7083_10100 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family G7083_10110 ENOG4105CHW UPF0052 protein G7083_10115 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) G7083_10120 ENOG4108RIR Molybdenum cofactor biosynthesis protein G7083_10125 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) G7083_10130 ENOG4105M00 molybdopterin converting factor, subunit 1 G7083_10135 ENOG4108ZAF Molybdopterin G7083_10140 ENOG4105BZU Histidine kinase G7083_10150 ENOG4108I5U Uridine phosphorylase G7083_10160 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) G7083_10165 ENOG4105D1F ATP-binding protein G7083_10170 ENOG4105DBI uridine monophosphokinase G7083_10175 ENOG4108GAE asmA family G7083_10180 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase G7083_10185 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation G7083_10190 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation G7083_10195 ENOG4105CHU acetyl-coa acetyltransferase G7083_10200 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase G7083_10205 ENOG41069NU Nitroreductase G7083_10210 ENOG4105EJC lysr family transcriptional regulator G7083_10225 ENOG4105I93 response regulator G7083_10230 ENOG4105WD1 Membrane G7083_10235 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) G7083_10240 ENOG4107QMP dna polymerase iii subunits gamma and tau G7083_10245 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) G7083_10250 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) G7083_10255 ENOG4105KRS Proteinase inhibitor G7083_10260 ENOG4108ZZ3 UPF0260 protein G7083_10265 ENOG4105UBK short-chain dehydrogenase reductase G7083_10270 ENOG4105ERU peptidase G7083_10280 ENOG4108XM1 transcriptional regulator AsnC family G7083_10285 ENOG4105C29 acyl-CoA thioesterase G7083_10320 ENOG4106AXJ AraC family transcriptional regulator G7083_10325 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) G7083_10330 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase G7083_10335 ENOG4105ETU transcriptional activator (TenA G7083_10340 ENOG4107Z6I Thiamine biosynthesis protein G7083_10345 ENOG4105Y36 Binding-protein-dependent transport systems, inner membrane component G7083_10350 ENOG4108YI8 ABC transporter G7083_10360 ENOG4108IEG Formate dehydrogenase Alpha subunit G7083_10380 ENOG4108V1U phospholipid-binding protein G7083_10395 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation G7083_10400 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) G7083_10405 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) G7083_10410 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) G7083_10415 ENOG4105K70 DNA-binding protein G7083_10420 ENOG4105EIN peptidylprolyl cis-trans isomerase G7083_10425 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein G7083_10430 ENOG4105CAT Cytidine monophosphate kinase G7083_10435 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) G7083_10440 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) G7083_10445 ENOG4105Q4A inner membrane protein yciS G7083_10450 ENOG4105CFV Tetratricopeptide repeat protein G7083_10465 ENOG4107R11 Transcriptional regulator G7083_10475 ENOG4105DCF alanine dehydrogenase G7083_10485 ENOG4105CNU cell division protein FtsK G7083_10490 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) G7083_10495 ENOG4105DKR Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) G7083_10500 ENOG4105C05 Multifunctional regulator of fatty acid metabolism (By similarity) G7083_10505 ENOG4108NVR Methyl-accepting chemotaxis G7083_10510 ENOG4105K59 histidine triad (HIT) protein G7083_10535 ENOG4105D0Y UPF0227 protein G7083_10540 ENOG4105CEP NADH dehydrogenase G7083_10555 ENOG4108JA2 transcriptioN-repair coupling factor G7083_10565 ENOG4105D60 lipoprotein releasing system transmembrane protein G7083_10570 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) G7083_10575 ENOG4105D60 lipoprotein releasing system transmembrane protein G7083_10585 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 G7083_10590 ENOG4105BZ1 (ABC) transporter G7083_10595 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) G7083_10600 ENOG4105W49 UPF0434 protein G7083_10605 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) G7083_10610 ENOG4105ED1 spovr family G7083_10615 ENOG4106AKX UPF0229 protein G7083_10620 ENOG4105CYN Serine protein kinase G7083_10625 ENOG4105XWI UPF0304 protein G7083_10630 ENOG4105F1A Pyruvate formate-lyase G7083_10640 ENOG4105C6N Formate acetyltransferase G7083_10645 ENOG4105E89 ABC transporter G7083_10650 ENOG4105CGK Exodeoxyribonuclease III G7083_10655 ENOG4106428 Protein of unknown function (DUF2496) G7083_10660 ENOG4108URS primosomal replication protein n'' G7083_10665 ENOG4105EJ9 Membrane G7083_10670 ENOG4105DVT helicase G7083_10680 ENOG4105K5B UPF0225 protein G7083_10685 ENOG4105D58 Diguanylate phosphodiesterase G7083_10690 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) G7083_10695 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) G7083_10700 ENOG4105C8N cysteinyl-tRNA synthetase G7083_10705 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) G7083_10710 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) G7083_10720 ENOG4105C4M (Ubiquinol oxidase) subunit I G7083_10725 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii G7083_10735 ENOG4105KJB cyd operon protein YbgE G7083_10740 ENOG4107YD3 Thioesterase G7083_10745 ENOG4105E02 MotA TolQ exbB proton channel G7083_10760 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) G7083_10765 ENOG4105KCK Peptidoglycan-associated lipoprotein G7083_10775 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) G7083_10800 ENOG4107QIV Cytochrome c biogenesis protein G7083_10810 ENOG4105CMR udp-glucose 4-epimerase G7083_10815 ENOG4105F0Z galactose-1-phosphate uridylyltransferase G7083_10820 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) G7083_10825 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) G7083_10830 ENOG41060NJ transcriptional regulator G7083_10835 ENOG41060NJ transcriptional regulator G7083_10845 ENOG4107FKK extracellular solute-binding protein family 1 G7083_10855 ENOG4105EG2 ABC transporter, permease G7083_10865 ENOG4105C4C beta-galactosidase G7083_10870 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) G7083_10875 ENOG4105C8Q Methyl-accepting chemotaxis G7083_10880 ENOG4105E7U AraC family transcriptional regulator G7083_10885 ENOG4105IGJ Zn-dependent Hydrolase of the beta-lactamase fold protein G7083_10890 ENOG4105DPZ Two component transcriptional regulator (Winged helix family G7083_10895 ENOG4105BZU Histidine kinase G7083_10905 ENOG4105C32 Amino acid ABC transporter (Permease) G7083_10915 ENOG4105C0Z ABC transporter G7083_10920 ENOG4108IV0 ABC, transporter G7083_10925 ENOG4108M9X Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) G7083_10930 ENOG4108YZ9 Urea amidohydrolase subunit gamma G7083_10935 ENOG4105KI2 Urea amidohydrolase subunit beta G7083_10940 ENOG4105CQM Urea amidohydrolase subunit alpha G7083_10945 ENOG4105MMR Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly (By similarity) G7083_10950 ENOG4108YH3 Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) G7083_10955 ENOG4105E8T Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) G7083_10965 ENOG4108RCM Nitroreductase G7083_10975 ENOG4105G6Z alkaline phosphatase G7083_10995 ENOG4105CK1 PTS System G7083_11000 ENOG41061TZ Short-chain dehydrogenase reductase Sdr G7083_11015 ENOG4105KAV tspo and mbr like protein G7083_11040 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase G7083_11045 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) G7083_11115 ENOG4105ENT Efflux transporter rnd family, mfp subunit G7083_11125 ENOG4105DY2 Paraquat-inducible protein b G7083_11130 ENOG4105F1S paraquat-inducible protein a G7083_11145 ENOG4107QPN acyl-Coa dehydrogenase G7083_11165 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) G7083_11175 ENOG4105RKX Protein of unknown function (DUF2498) G7083_11180 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) G7083_11190 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) G7083_11205 ENOG4105HP8 regulator of competence-specific genes G7083_11210 ENOG4105ETE Transcriptional regulator (LacI family G7083_11215 ENOG4107S90 membrAne G7083_11220 ENOG4106371 Methyltransferase G7083_11225 ENOG4105GHU Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity (By similarity) G7083_11230 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) G7083_11235 ENOG4105DUC Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division (By similarity) G7083_11240 ENOG4105CCT upf0313 protein G7083_11255 ENOG4105DZ2 Transcriptional regulator G7083_11260 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) G7083_11270 ENOG4105K9H YciI-like protein G7083_11275 ENOG4105NAU thioesterase Superfamily protein G7083_11285 ENOG4105GFG DUF218 domain G7083_11295 ENOG4105TMB Formate nitrite transporter G7083_11300 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase G7083_11310 ENOG4108JQ2 peptide transport system atp-binding protein G7083_11315 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein G7083_11320 ENOG4108EU3 peptide transport system, permease G7083_11325 ENOG4108I5W peptide transport system, permease protein G7083_11330 ENOG4108J59 Extracellular solute-binding protein, family 5 G7083_11335 ENOG4108R3E Dna-3-methyladenine glycosylase i G7083_11340 ENOG4105C28 cystathionine G7083_11350 ENOG4105C8J )-transporter G7083_11355 ENOG4108W1A pseudouridine synthase G7083_11370 ENOG4107QWP ABC-2 type transporter G7083_11375 ENOG4105CJ1 ABC, transporter G7083_11385 ENOG4105C44 Serine transporter G7083_11400 ENOG4105BZU Histidine kinase G7083_11410 ENOG4108N3W hemolysin secretion protein G7083_11415 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) G7083_11420 ENOG4105CFI type iii restriction protein res subunit G7083_11425 ENOG4105I08 Pseudouridine synthase G7083_11430 ENOG4105C2C drug resistance transporter, Bcr CflA G7083_11440 ENOG4105CGD Nad-dependent epimerase dehydratase G7083_11445 ENOG4107QI1 Mate efflux family protein G7083_11450 ENOG4108I0Y (ABC) transporter G7083_11465 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) G7083_11475 ENOG4105E3Q saccharopine dehydrogenase G7083_11480 ENOG4105D3D Catalyzes the decarboxylation of carboxynorspermidine and carboxyspermidine (By similarity) G7083_11485 ENOG4105CDV Ompa motb domain protein G7083_11500 ENOG4108VKG metal-dependent hydrolase G7083_11505 ENOG4105EBA Specifically methylates the adenine in position 1618 of 23S rRNA (By similarity) G7083_11520 ENOG4105CVG Homoserine O-transsuccinylase G7083_11535 ENOG4107V40 secretion protein, HlyD family G7083_11555 ENOG4107R88 Chemotaxis protein (CheV) G7083_11580 ENOG4107SV5 CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) G7083_11590 ENOG4105ENG CRISPR-associated protein, Csy1 family G7083_11610 ENOG4105F88 accessory colonization factor AcfD G7083_11625 ENOG4105BZU Histidine kinase G7083_11630 ENOG4105BZU Histidine kinase G7083_11635 ENOG4105V0I UPF0267 protein G7083_11650 ENOG4105CS2 ec 3.2.1.21 G7083_11660 ENOG4107YYT May reduce aminoacrylate peracid to aminoacrylate. Required to remove a toxic intermediate produce by the pyrimidine nitrogen degradation (By similarity) G7083_11665 ENOG4105XEP YhcH YjgK YiaL family protein G7083_11670 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase G7083_11675 ENOG4105E98 transcriptional regulator DeoR family G7083_11680 ENOG4108IJ9 (ABC) transporter G7083_11685 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component G7083_11690 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component G7083_11695 ENOG4105BZ7 extracellular solute-binding protein family 1 G7083_11720 ENOG4109015 Biopolymer transport protein exbD tolR G7083_11740 ENOG4107QI1 Mate efflux family protein G7083_11755 ENOG4107TT5 NLP P60 protein G7083_11760 ENOG4107SDU Methyl-accepting chemotaxis G7083_11765 ENOG4106IUH DTW domain containing protein G7083_11770 ENOG4105EZX Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P (By similarity) G7083_11780 ENOG4105CVM Molybdenum cofactor synthesis domain protein G7083_11785 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) G7083_11790 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) G7083_11795 ENOG4107A5B Binding-protein-dependent transport systems, inner membrane component G7083_11805 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family G7083_11810 ENOG4105BZU Histidine kinase G7083_11905 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) G7083_11910 ENOG41082NX 50s ribosomal protein l35 G7083_11915 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) G7083_11920 ENOG4105C22 threonyL-tRNA synthetase G7083_11925 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) G7083_11930 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) G7083_11935 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor G7083_11950 ENOG4105DZ1 carboxypeptidase G7083_11955 ENOG4105CYW agmatinase G7083_11960 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) G7083_11970 ENOG4105CJW magnesium transporter G7083_11975 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) G7083_11985 ENOG4105C37 (CBS) domain G7083_11990 ENOG4107YWA deoxycytidylate deaminase G7083_12005 ENOG4108VAC response regulator G7083_12010 ENOG4108HRK Histidine kinase G7083_12025 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) G7083_12030 ENOG4105C19 ABC transporter G7083_12035 ENOG4107RGM aldo keto reductase G7083_12040 ENOG4107T9C Alpha amylase catalytic region G7083_12050 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase G7083_12055 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) G7083_12065 ENOG4108IPW abc transporter atp-binding protein G7083_12070 ENOG4105CM4 permease protein G7083_12075 ENOG4105DHS permease protein G7083_12085 ENOG4108N3W hemolysin secretion protein G7083_12095 ENOG4105E5M Multidrug resistance protein D G7083_12100 ENOG4107S6Z Na H antiporter G7083_12105 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) G7083_12110 ENOG4107RA1 nh(3)-dependent nad( ) synthetase G7083_12115 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter G7083_12135 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving G7083_12165 ENOG4105CPQ Dehydrogenase G7083_12170 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) G7083_12175 ENOG4108IQK o-acetylhomoserine G7083_12180 ENOG4105EXG Transcriptional regulator G7083_12185 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase G7083_12190 ENOG4107SSZ Phosphatase G7083_12195 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase G7083_12200 ENOG4108Q79 6-phosphogluconolactonase (EC 3.1.1.31) G7083_12205 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) G7083_12215 ENOG4105PYN Pyridoxamine 5-phosphate oxidase-related G7083_12220 ENOG41090JE Utilization Protein G7083_12225 ENOG4105D4P Coproporphyrinogen iii oxidase G7083_12230 ENOG4105WQ5 TonB family G7083_12235 ENOG41090AP transport protein G7083_12240 ENOG4106GFD transport protein G7083_12245 ENOG4107R4I Periplasmic binding protein G7083_12250 ENOG4105EHG Permease protein G7083_12255 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) G7083_12285 ENOG4105QVC MOSC domain-containing protein G7083_12290 ENOG4105EKE dihydroorotase G7083_12295 ENOG4107SFS Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA (By similarity) G7083_12310 ENOG4105E98 transcriptional regulator DeoR family G7083_12320 ENOG4105EG2 ABC transporter, permease G7083_12325 ENOG4105D56 permease protein G7083_12330 ENOG4107FKK extracellular solute-binding protein family 1 G7083_12335 ENOG4108IJ9 (ABC) transporter G7083_12340 ENOG41086KC Transcriptional regulator G7083_12345 ENOG4105KQ5 peptidylprolyl cis-trans isomerase G7083_12360 ENOG4105BZU Histidine kinase G7083_12365 ENOG4107RH7 Nicotinate phosphoribosyltransferase G7083_12380 ENOG4108P2H Inner membrane protein YjiG G7083_12385 ENOG41074DU domain protein G7083_12390 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) G7083_12410 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) G7083_12420 ENOG4107W52 maltose operon periplasmic protein G7083_12425 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) G7083_12440 ENOG4105C1J atp-dependent rna helicase G7083_12445 ENOG4105BZ1 (ABC) transporter G7083_12455 ENOG4105CCF Lysine exporter protein (Lyse ygga) G7083_12465 ENOG4105K56 Transcriptional regulator G7083_12470 ENOG4108ZHJ Organic hydroperoxide resistance protein G7083_12485 ENOG4105DR5 peptidase G7083_12495 ENOG4105CHH sulfate transporter G7083_12500 ENOG4105DWD nucleoside recognition domain protein G7083_12510 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) G7083_12515 ENOG4105E2Z phosphate ABC transporter (Permease G7083_12520 ENOG4105C8U phosphate abc transporter G7083_12525 ENOG4105CVA phosphate G7083_12530 ENOG4105C1J atp-dependent rna helicase G7083_12540 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein G7083_12545 ENOG4105CVP deoxyribo-dipyrimidine photolyase G7083_12550 ENOG4107SEY Conserved Protein G7083_12560 ENOG4106TD9 Diguanylate cyclase G7083_12570 ENOG4105D6U Sodium Glutamate Symporter G7083_12585 ENOG4107QV7 Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) G7083_12590 ENOG4105EYK Phosphatidylglycerophosphatase B G7083_12610 ENOG4105C8Q Methyl-accepting chemotaxis G7083_12620 ENOG4105CK7 Sodium proline symporter G7083_12640 ENOG4105E6M Sulphatase-modifying factor protein G7083_12650 ENOG4107QZV Type I secretion membrane fusion protein G7083_12665 ENOG4108JJA ABC, transporter G7083_12680 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component G7083_12685 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component G7083_12690 ENOG4108JQ6 ABC transporter G7083_12695 ENOG4105DHQ Histidine kinase G7083_12700 ENOG4105XJC Two component transcriptional regulator (Winged helix family G7083_12710 ENOG4108IXY short-chain dehydrogenase reductase G7083_12730 ENOG4105E0I Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity) G7083_12735 ENOG4107RUE extracellular solute-binding protein family 1 G7083_12740 ENOG4106RMF ParB family G7083_12765 ENOG4105CDY transcriptional regulatory protein G7083_12770 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase G7083_12775 ENOG4108YYI Protein of unknown function (DUF2810) G7083_12780 ENOG41061ZR Transcriptional regulator G7083_12785 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) G7083_12790 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) G7083_12795 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) G7083_12805 ENOG4105C8P )-transporter G7083_12810 ENOG4108Q67 UPF0319 protein G7083_12830 ENOG4105DR5 peptidase G7083_12840 ENOG4107QSU Phosphoglucomutase phosphomannomutase alpha beta alpha domain G7083_12845 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) G7083_12860 ENOG4105VEQ Cold shock protein G7083_12895 ENOG4105C7R Atpase associated with various cellular activities aaa_3 G7083_12900 ENOG4108N3W hemolysin secretion protein G7083_12910 ENOG4108JUA Transcriptional regulator G7083_12915 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) G7083_12920 ENOG4105VEQ Cold shock protein G7083_12930 ENOG4108UNF response regulator G7083_12940 ENOG4105C5I Dehydrogenase G7083_12960 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) G7083_12965 ENOG4107VXZ Hydrolase G7083_12975 ENOG4105D3G Pseudouridine synthase G7083_12985 ENOG4108RVA ribokinase G7083_12995 ENOG4105EDR glucose galactose transporter G7083_13000 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) G7083_13010 ENOG4105CXY transporter G7083_13020 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) G7083_13050 ENOG410907W The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in ascorbate transport G7083_13055 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia G7083_13060 ENOG4105ETE Transcriptional regulator (LacI family G7083_13070 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component G7083_13085 ENOG4105DFY n-acylglucosamine 2-epimerase G7083_13110 ENOG4105CAC Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) G7083_13115 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase G7083_13120 ENOG4105EF1 ribulokinase G7083_13125 ENOG4105DMK Periplasmic binding protein LacI transcriptional regulator G7083_13130 ENOG4105C2J ABC transporter G7083_13135 ENOG4105CNN ABC, transporter G7083_13145 ENOG4108M1A Chitin-binding protein G7083_13155 ENOG4105CVA phosphate G7083_13170 ENOG4105C1J atp-dependent rna helicase G7083_13175 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) G7083_13180 ENOG4107RCV ABC transporter, permease G7083_13190 ENOG4105BZU Histidine kinase G7083_13195 ENOG4108KX4 response regulator G7083_13200 ENOG4107RE1 Inosine-guanosine kinase G7083_13215 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) G7083_13230 ENOG4105RKW reductase (By G7083_13245 ENOG4105CV6 ABC transporter, permease G7083_13250 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase G7083_13255 ENOG4105CMR udp-glucose 4-epimerase G7083_13260 ENOG4105E0U tyrosine-specific transport protein G7083_13265 ENOG4105C1J atp-dependent rna helicase G7083_13270 ENOG4107XI7 Tetr family transcriptional regulator G7083_13285 ENOG4107R4Q Functions as an ATPase. May play a role in metal insertion (metal-chelatase) or as a chaperone (By similarity) G7083_13290 ENOG4105EV2 VWA domain protein interacting with AAA ATPase G7083_13295 ENOG4105E5Z arginine transporter ATP-binding subunit G7083_13300 ENOG4106PMH Extracellular solute-binding protein family 3 G7083_13305 ENOG4105GBT ABC transporter G7083_13310 ENOG4105DMR ABC, transporter G7083_13315 ENOG4105DUM transcriptional regulator, lysR family G7083_13335 ENOG4105K63 Thioredoxin G7083_13340 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) G7083_13345 ENOG4108KJ0 anaerobic glycerol-3-phosphate dehydrogenase, subunit B G7083_13350 ENOG4107R5Y anaerobic glycerol-3-phosphate dehydrogenase, subunit A G7083_13355 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) G7083_13365 ENOG41090HJ UPF0265 protein G7083_13375 ENOG4108YXG UPF0502 protein G7083_13380 ENOG41082IR Excinuclease ABC C subunit domain protein G7083_13395 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) G7083_13405 ENOG4105E0C molybdate abc transporter G7083_13410 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) G7083_13420 ENOG4105EM2 membrane G7083_13425 ENOG41088T4 Helicase IV G7083_13430 ENOG41080IJ Diacylglycerol kinase G7083_13435 ENOG4108RWI nicotinamidase G7083_13440 ENOG4108Z5K methylglyoxal synthase G7083_13445 ENOG4108I6A alcohol dehydrogenase G7083_13450 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) G7083_13455 ENOG4105BZU Histidine kinase G7083_13460 ENOG4105CKI cobalamin synthesis protein G7083_13465 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) G7083_13470 ENOG4105BZU Histidine kinase G7083_13475 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein G7083_13480 ENOG4105VYA Uncharacterized conserved protein (DUF2132) G7083_13490 ENOG4105BZU Histidine kinase G7083_13500 ENOG4107KGK dmso reductase anchor subunit G7083_13505 ENOG4105QAX Iron-sulfur G7083_13510 ENOG4107QY8 reductase G7083_13515 ENOG4108NEM leader-binding protein dmsD G7083_13525 ENOG4107QI1 Mate efflux family protein G7083_13535 ENOG4105D3P Mannan endo-1,4-beta-mannosidase G7083_13545 ENOG4105ETE Transcriptional regulator (LacI family G7083_13550 ENOG4105DIQ Transcriptional regulator G7083_13560 ENOG4105CKB glycosidase G7083_13565 ENOG4105HY2 Glycosidase related protein G7083_13570 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) G7083_13575 ENOG4108W2P Methyl-accepting chemotaxis G7083_13580 ENOG4105EIP mannose-6-phosphate isomerase G7083_13585 ENOG4108N3W hemolysin secretion protein G7083_13590 ENOG4107ENK receptor G7083_13595 ENOG4105CWB LysR family transcriptional Regulator G7083_13605 ENOG4105CPF Cell wall formation (By similarity) G7083_13615 ENOG4108ZJT translation initiation factor, Sui1 G7083_13620 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase G7083_13625 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) G7083_13630 ENOG4105CGF Aromatic amino acid aminotransferase G7083_13635 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) G7083_13640 ENOG4105DM4 PTS System G7083_13645 ENOG4105DE4 1-phosphofructokinase G7083_13650 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein G7083_13655 ENOG4107B7Y DNA-binding transcriptional regulator FruR G7083_13660 ENOG4107RFY SbcCD D subunit G7083_13665 ENOG4105EYH Exonuclease G7083_13680 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) G7083_13685 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) G7083_13705 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) G7083_13720 ENOG4105BZU Histidine kinase G7083_13725 ENOG4105WH1 Two component transcriptional regulator luxr family G7083_13730 ENOG4108N3W hemolysin secretion protein G7083_13735 ENOG4107VXZ Hydrolase G7083_13740 ENOG4108V1T peptidylprolyl cis-trans isomerase G7083_13745 ENOG4105CDV Ompa motb domain protein G7083_13755 ENOG4105C6V Glycerol-3-phosphate dehydrogenase G7083_13760 ENOG4105D7K pfkb domain protein G7083_13765 ENOG4108M0B Sucrose porin G7083_13785 ENOG4105CV1 Transketolase (EC 2.2.1.1) G7083_13795 ENOG4107RHR regulatoR G7083_13800 ENOG4105KHC sulfurtransferase G7083_13805 ENOG4105D06 uba thif-type nad fad binding protein G7083_13810 ENOG4105CVM Molybdenum cofactor synthesis domain protein G7083_13815 ENOG4105EUJ GTP cyclohydrolase i G7083_13820 ENOG4105CUB amino acid G7083_13850 ENOG4105VXN addiction module toxin, RelE StbE family G7083_13905 ENOG4107FQ9 ethanolamine ammonia-lyase G7083_13910 ENOG4105CPD ethanolamine ammonia-lyase G7083_13915 ENOG4105CKU formyltetrahydrofolate synthetase G7083_13920 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) G7083_13925 ENOG4105PAD Hydrolase G7083_13935 ENOG4108KAZ Involved in phosphonate degradation (By similarity) G7083_13940 ENOG4108JPW Aminotransferase G7083_13945 ENOG4107STF Involved in phosphonate degradation (By similarity) G7083_13960 ENOG4107RCV ABC transporter, permease G7083_13970 ENOG41061WM D-Alanyl-D-Alanine G7083_13975 ENOG4105ETE Transcriptional regulator (LacI family G7083_13985 ENOG4105ECY inositol monophosphatase G7083_13995 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) G7083_14000 ENOG4107RCV ABC transporter, permease G7083_14045 ENOG4105BZS acriflavin resistance protein G7083_14050 ENOG4105EPM Diguanylate phosphodiesterase G7083_14060 ENOG4105DS1 cytochrome b561 G7083_14065 ENOG4108YYC ycei family G7083_14070 ENOG4105CPB ATP-dependent endonuclease of the OLD family G7083_14075 ENOG4105CGH 5'-nucleotidase G7083_14080 ENOG4105DU1 integral membrane protein, terc G7083_14090 ENOG41064RH membrane protein YliF G7083_14105 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) G7083_14110 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) G7083_14120 ENOG4105CK6 Two component transcriptional regulator (Winged helix family G7083_14140 ENOG4105KA0 thioesterase Superfamily protein G7083_14155 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA G7083_14165 ENOG4108JQ5 ABC transporter G7083_14170 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component G7083_14175 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component G7083_14180 ENOG4105E43 Extracellular solute-binding protein, family 5 G7083_14190 ENOG4105C5Y PTS System G7083_14200 ENOG4107R3K hydrolase G7083_14210 ENOG4105RA2 Membrane G7083_14215 ENOG4105M6F mutator MutT protein G7083_14220 ENOG4105DAN ATP-dependent protease G7083_14230 ENOG4105NBK UPF0345 protein G7083_14270 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase G7083_14275 ENOG4105VDM plasmid maintenance system antidote protein, xre family G7083_14280 ENOG41080ET plasmid maintenance system killer protein G7083_14335 ENOG4105VDM plasmid maintenance system antidote protein, xre family G7083_14340 ENOG41080ET plasmid maintenance system killer protein G7083_14595 ENOG4109025 Glyoxalase Bleomycin resistance protein (Dioxygenase G7083_14605 ENOG4109025 Glyoxalase Bleomycin resistance protein (Dioxygenase G7083_14765 ENOG4105DSM The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components the iron protein and the molybdenum-iron protein (By similarity)