locus-tag	class	description
M4S28_00010	COG1494	fructose-1,6-bisphosphatase
M4S28_00015	COG3074	FtsZ-dependent cytokinesis
M4S28_00060	COG1609	Transcriptional regulator
M4S28_00070	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
M4S28_00075	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
M4S28_00080	COG1575	Belongs to the MenA family. Type 1 subfamily
M4S28_00085	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
M4S28_00090	COG3074	FtsZ-dependent cytokinesis
M4S28_00095	COG1494	fructose-1,6-bisphosphatase
M4S28_00110	COG3152	Membrane
M4S28_00125	COG2852	Protein conserved in bacteria
M4S28_00135	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
M4S28_00145	COG0745	RESPONSE REGULATOR receiver
M4S28_00150	COG2205	protein histidine kinase activity
M4S28_00160	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
M4S28_00170	COG1027	Aspartate ammonia-lyase
M4S28_00175	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
M4S28_00180	COG1288	antiporter activity
M4S28_00195	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
M4S28_00200	COG0540	Belongs to the ATCase OTCase family
M4S28_00205	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
M4S28_00210	COG1438	arginine binding
M4S28_00215	COG4232	protein-disulfide reductase activity
M4S28_00225	COG3263	regulation of cellular component size
M4S28_00235	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M4S28_00250	COG2198	Histidine kinase
M4S28_00250	COG0784	Response regulator, receiver
M4S28_00250	COG2205	protein histidine kinase activity
M4S28_00255	COG2814	Major facilitator Superfamily
M4S28_00270	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M4S28_00275	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
M4S28_00280	COG0511	ligase activity, forming carbon-carbon bonds
M4S28_00285	COG0439	Biotin carboxylase
M4S28_00290	COG2264	protein methyltransferase activity
M4S28_00295	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
M4S28_00300	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
M4S28_00305	COG0789	Transcriptional regulator
M4S28_00310	COG0138	bifunctional purine biosynthesis protein purh
M4S28_00315	COG0151	Belongs to the GarS family
M4S28_00330	COG1253	flavin adenine dinucleotide binding
M4S28_00335	COG3068	Protein conserved in bacteria
M4S28_00345	COG1573	uracil-dna glycosylase
M4S28_00355	COG2816	NAD+ diphosphatase activity
M4S28_00360	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
M4S28_00375	COG0222	ribosome binding
M4S28_00380	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
M4S28_00385	COG0081	regulation of translation
M4S28_00395	COG0250	Participates in transcription elongation, termination and antitermination
M4S28_00400	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
M4S28_00430	COG1072	(Pantothenic acid kinase))
M4S28_00440	COG0812	UDP-N-acetylmuramate dehydrogenase activity
M4S28_00450	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M4S28_00550	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
M4S28_00565	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
M4S28_00585	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M4S28_00590	COG0534	Mate efflux family protein
M4S28_00595	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
M4S28_00600	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
M4S28_00605	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
M4S28_00610	COG2937	Belongs to the GPAT DAPAT family
M4S28_00615	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
M4S28_00620	COG3161	chorismate lyase activity
M4S28_00625	COG1580	Controls the rotational direction of flagella during chemotaxis
M4S28_00630	COG0705	Rhomboid family
M4S28_00635	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
M4S28_00645	COG2177	Part of the ABC transporter FtsEX involved in
M4S28_00650	COG2884	Cell division ATP-binding protein ftsE
M4S28_00655	COG0552	protein localization to endoplasmic reticulum
M4S28_00655	COG0552	protein localization to endoplasmic reticulum
M4S28_00660	COG0742	ribosomal rna small subunit methyltransferase
M4S28_00670	COG2095	MarC family integral membrane protein
M4S28_00710	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
M4S28_00715	COG0640	Transcriptional regulator
M4S28_00720	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
M4S28_00725	COG1280	lysine exporter protein (LysE YggA)
M4S28_00730	COG2267	carboxylic ester hydrolase activity
M4S28_00735	COG0561	phosphatase activity
M4S28_00750	COG3148	PFAM DTW domain containing protein
M4S28_00755	COG2200	EAL domain
M4S28_00755	COG3287	FIST C domain
M4S28_00755	COG2199	diguanylate cyclase activity
M4S28_00760	COG2199	diguanylate cyclase activity
M4S28_00760	COG3287	FIST C domain
M4S28_00760	COG2200	EAL domain
M4S28_00765	COG1011	Hydrolase
M4S28_00770	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
M4S28_00780	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
M4S28_00785	COG0019	diaminopimelate decarboxylase activity
M4S28_00795	COG1965	Belongs to the frataxin family
M4S28_00800	COG3072	Adenylate cyclase
M4S28_00805	COG0181	hydroxymethylbilane synthase activity
M4S28_00810	COG1587	Uroporphyrinogen-III synthase
M4S28_00815	COG2959	enzyme of heme biosynthesis
M4S28_00820	COG3071	HemY protein
M4S28_00825	COG3385	transposase activity
M4S28_00880	COG2871	sodium ion transport
M4S28_00885	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
M4S28_00900	COG3118	belongs to the thioredoxin family
M4S28_00905	COG0513	Belongs to the DEAD box helicase family
M4S28_00910	COG0248	Ppx GppA phosphatase
M4S28_00915	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
M4S28_00925	COG0514	ATP-dependent DNA helicase (RecQ)
M4S28_00930	COG2962	Rard protein
M4S28_00940	COG1280	lysine exporter protein (LysE YggA)
M4S28_00945	COG0405	Gamma-glutamyltransferase
M4S28_00955	COG0210	DNA helicase
M4S28_00965	COG3220	belongs to the UPF0276 family
M4S28_00995	COG0006	proline dipeptidase activity
M4S28_00995	COG0006	proline dipeptidase activity
M4S28_01005	COG2022	thiamine diphosphate biosynthetic process
M4S28_01010	COG2104	thiamine diphosphate biosynthetic process
M4S28_01020	COG0352	thiamine-phosphate diphosphorylase activity
M4S28_01025	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
M4S28_01035	COG2132	Multicopper oxidase
M4S28_01080	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
M4S28_01090	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
M4S28_01095	COG0408	coproporphyrinogen oxidase activity
M4S28_01100	COG0009	L-threonylcarbamoyladenylate synthase
M4S28_01105	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
M4S28_01110	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
M4S28_01115	COG0551	DNA topoisomerase type I activity
M4S28_01120	COG2922	Belongs to the Smg family
M4S28_01125	COG0758	DNA mediated transformation
M4S28_01140	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
M4S28_01145	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
M4S28_01145	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
M4S28_01150	COG0569	domain protein
M4S28_01155	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
M4S28_01165	COG1272	protein, Hemolysin III
M4S28_01170	COG4326	sporulation control protein
M4S28_01180	COG3084	Protein conserved in bacteria
M4S28_01190	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
M4S28_01195	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M4S28_01205	COG0606	chelatase, subunit chli
M4S28_01215	COG3978	acetolactate synthase activity
M4S28_01220	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
M4S28_01225	COG0129	dihydroxy-acid dehydratase activity
M4S28_01235	COG0583	DNA-binding transcription factor activity
M4S28_01240	COG2814	Major facilitator Superfamily
M4S28_01250	COG0355	proton-transporting ATP synthase activity, rotational mechanism
M4S28_01255	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
M4S28_01260	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
M4S28_01265	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
M4S28_01270	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
M4S28_01275	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
M4S28_01290	COG3312	ion transport
M4S28_01295	COG1475	DNA binding
M4S28_01300	COG1192	Involved in chromosome partitioning
M4S28_01305	COG0357	Ribosomal RNA small subunit methyltransferase G
M4S28_01310	COG0445	tRNA wobble uridine modification
M4S28_01315	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
M4S28_01325	COG0706	membrane insertase activity
M4S28_01330	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
M4S28_01335	COG0594	ribonuclease P activity
M4S28_01340	COG0230	Belongs to the bacterial ribosomal protein bL34 family
M4S28_01345	COG1126	abc transporter atp-binding protein
M4S28_01360	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
M4S28_01365	COG0592	DNA-directed DNA polymerase activity
M4S28_01370	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
M4S28_01375	COG0187	DNA topoisomerase II activity
M4S28_01385	COG3977	Valine--pyruvate aminotransferase
M4S28_01390	COG0366	Alpha amylase catalytic
M4S28_01395	COG0751	glycine-tRNA ligase activity
M4S28_01400	COG0752	glycyl-tRNA synthetase alpha subunit
M4S28_01405	COG2119	membrane
M4S28_01415	COG0425	Belongs to the sulfur carrier protein TusA family
M4S28_01430	COG0604	alcohol dehydrogenase
M4S28_01435	COG0183	Belongs to the thiolase family
M4S28_01440	COG1250	3-hydroxyacyl-CoA dehydrogenase
M4S28_01440	COG1024	Enoyl-CoA hydratase
M4S28_01445	COG1739	Uncharacterized protein family UPF0029
M4S28_01450	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
M4S28_01500	COG0583	DNA-binding transcription factor activity
M4S28_01505	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
M4S28_01510	COG2960	long-chain fatty acid transporting porin activity
M4S28_01515	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M4S28_01520	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M4S28_01525	COG1309	transcriptional regulator
M4S28_01580	COG0601	transmembrane transport
M4S28_01585	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M4S28_01605	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M4S28_01610	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
M4S28_01620	COG1522	sequence-specific DNA binding
M4S28_01625	COG5002	protein histidine kinase activity
M4S28_01625	COG5001	Diguanylate cyclase
M4S28_01630	COG0742	ribosomal rna small subunit methyltransferase
M4S28_01645	COG0589	response to stress
M4S28_01650	COG1528	Iron-storage protein
M4S28_01660	COG2081	HI0933 family
M4S28_01695	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
M4S28_01710	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
M4S28_01750	COG0348	domain, Protein
M4S28_01750	COG3901	Regulator of nitric oxide reductase transcription
M4S28_01760	COG1322	Protein conserved in bacteria
M4S28_01765	COG2226	methyltransferase
M4S28_01770	COG3165	ubiquinone biosynthetic process from chorismate
M4S28_01775	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
M4S28_01780	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
M4S28_01785	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
M4S28_01790	COG0805	protein transport
M4S28_01795	COG0084	hydrolase, TatD family'
M4S28_01810	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M4S28_01810	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M4S28_01835	COG3078	GTPase activator activity
M4S28_01845	COG0635	Involved in the biosynthesis of porphyrin-containing compound
M4S28_01860	COG3852	Histidine kinase
M4S28_01870	COG0174	glutamine synthetase
M4S28_01875	COG1217	gtp-binding protein TYPA
M4S28_01890	COG1295	ribonuclease BN
M4S28_01895	COG1490	D-aminoacyl-tRNA deacylase activity
M4S28_01900	COG0456	acetyltransferase
M4S28_01910	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
M4S28_01920	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
M4S28_01925	COG3031	protein transport across the cell outer membrane
M4S28_01935	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
M4S28_01940	COG1459	type II secretion system
M4S28_01945	COG2165	general secretion pathway protein
M4S28_01950	COG2165	general secretion pathway protein
M4S28_01955	COG2165	general secretion pathway protein
M4S28_01960	COG4795	General secretion pathway protein
M4S28_01965	COG3156	type II secretion system protein K
M4S28_01970	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
M4S28_01975	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
M4S28_01985	COG1218	3'(2'),5'-bisphosphate nucleotidase
M4S28_01990	COG0494	nUDIX hydrolase
M4S28_01995	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
M4S28_01995	COG0316	Belongs to the HesB IscA family
M4S28_02000	COG1040	competence protein
M4S28_02005	COG0596	Alpha beta hydrolase
M4S28_02015	COG2183	response to ionizing radiation
M4S28_02020	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
M4S28_02035	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
M4S28_02040	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
M4S28_02045	COG1758	RNA polymerase activity
M4S28_02050	COG0194	GDP metabolic process
M4S28_02055	COG2252	PERMEase
M4S28_02070	COG1278	Cold shock
M4S28_02075	COG1561	YicC-like family, N-terminal region
M4S28_02080	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
M4S28_02085	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
M4S28_02090	COG1560	Kdo2-lipid A biosynthetic process
M4S28_02095	COG1309	transcriptional regulator
M4S28_02105	COG2003	Belongs to the UPF0758 family
M4S28_02110	COG0227	Belongs to the bacterial ribosomal protein bL28 family
M4S28_02115	COG0267	Belongs to the bacterial ribosomal protein bL33 family
M4S28_02125	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
M4S28_02145	COG0859	PFAM glycosyl transferase family 9
M4S28_02150	COG3642	lipopolysaccharide core region biosynthetic process
M4S28_02155	COG1519	Transferase
M4S28_02165	COG0463	Glycosyl transferase, family 2
M4S28_02180	COG0438	transferase activity, transferring glycosyl groups
M4S28_02200	COG1560	Kdo2-lipid A biosynthetic process
M4S28_02220	COG4942	peptidase
M4S28_02225	COG1045	serine acetyltransferase
M4S28_02235	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
M4S28_02240	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
M4S28_02260	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
M4S28_02265	COG1596	polysaccharide export
M4S28_02280	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
M4S28_02295	COG1086	Polysaccharide biosynthesis protein
M4S28_02300	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
M4S28_02305	COG1083	cytidylyl-transferase
M4S28_02315	COG2089	acid synthase
M4S28_02325	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
M4S28_02365	COG0367	asparagine synthase
M4S28_02370	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M4S28_02375	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
M4S28_02375	COG2755	lipolytic protein G-D-S-L family
M4S28_02385	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
M4S28_02390	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
M4S28_02410	COG0534	Mate efflux family protein
M4S28_02415	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
M4S28_02440	COG2199	diguanylate cyclase activity
M4S28_02440	COG2203	Gaf domain
M4S28_02445	COG1285	pathogenesis
M4S28_02455	COG1509	lysine 2,3-aminomutase activity
M4S28_02460	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
M4S28_02470	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
M4S28_02475	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
M4S28_02480	COG1053	succinate dehydrogenase
M4S28_02485	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
M4S28_02495	COG0840	transmembrane signaling receptor activity
M4S28_02500	COG0471	metal ion transport
M4S28_02500	COG0490	domain, Protein
M4S28_02510	COG1162	GTPase activity
M4S28_02605	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
M4S28_02610	COG0802	atpase or kinase
M4S28_02615	COG0860	N-Acetylmuramoyl-L-alanine amidase
M4S28_02620	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
M4S28_02625	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
M4S28_02630	COG1923	regulation of RNA biosynthetic process
M4S28_02635	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
M4S28_02640	COG0330	HflC and HflK could
M4S28_02645	COG0330	HflC and HflK could
M4S28_02650	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
M4S28_02655	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
M4S28_02660	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
M4S28_02665	COG0402	S-adenosylhomocysteine deaminase activity
M4S28_02670	COG0557	exoribonuclease II activity
M4S28_02675	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M4S28_02680	COG0360	Binds together with S18 to 16S ribosomal RNA
M4S28_02690	COG0359	binds to the 23S rRNA
M4S28_02705	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
M4S28_02715	COG0432	Pfam Uncharacterised protein family UPF0047
M4S28_02720	COG0166	Belongs to the GPI family
M4S28_02725	COG3385	transposase activity
M4S28_02735	COG0735	belongs to the Fur family
M4S28_02775	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
M4S28_02780	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M4S28_02785	COG0175	sulfate reduction
M4S28_02870	COG0527	aspartate kinase activity
M4S28_02875	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
M4S28_02885	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
M4S28_02895	COG2197	response regulator
M4S28_02900	COG0629	single-stranded DNA binding
M4S28_02905	COG2199	diguanylate cyclase activity
M4S28_02905	COG2200	EAL domain
M4S28_02930	COG3409	Peptidoglycan-binding domain 1 protein
M4S28_02930	COG3267	Type II secretory pathway component ExeA
M4S28_02940	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
M4S28_02945	COG1459	type II secretion system
M4S28_02955	COG2165	general secretion pathway protein
M4S28_02960	COG2165	general secretion pathway protein
M4S28_02990	COG1077	Cell shape determining protein MreB Mrl
M4S28_02995	COG1792	Involved in formation and maintenance of cell shape
M4S28_03000	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
M4S28_03005	COG0424	maF-like protein
M4S28_03020	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
M4S28_03025	COG0312	modulator of DNA gyrase
M4S28_03030	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
M4S28_03035	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
M4S28_03050	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
M4S28_03055	COG0589	response to stress
M4S28_03070	COG1438	arginine binding
M4S28_03075	COG0039	L-malate dehydrogenase activity
M4S28_03085	COG0142	geranyltranstransferase activity
M4S28_03090	COG0261	This protein binds to 23S rRNA in the presence of protein L20
M4S28_03095	COG0211	Belongs to the bacterial ribosomal protein bL27 family
M4S28_03100	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
M4S28_03105	COG2966	Psort location CytoplasmicMembrane, score
M4S28_03110	COG3610	response to peptide
M4S28_03125	COG2967	ApaG domain
M4S28_03130	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
M4S28_03135	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
M4S28_03140	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M4S28_03145	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
M4S28_03150	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
M4S28_03165	COG0066	3-isopropylmalate dehydratase activity
M4S28_03175	COG0473	3-isopropylmalate dehydrogenase activity
M4S28_03180	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
M4S28_03215	COG1022	Amp-dependent synthetase and ligase
M4S28_03220	COG0028	Belongs to the TPP enzyme family
M4S28_03230	COG3706	GGDEF domain
M4S28_03235	COG1802	Transcriptional regulator
M4S28_03240	COG0469	pyruvate kinase activity
M4S28_03245	COG1349	DNA-binding transcription factor activity
M4S28_03250	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
M4S28_03255	COG2873	o-acetylhomoserine
M4S28_03275	COG1610	YqeY-like protein
M4S28_03280	COG0828	Belongs to the bacterial ribosomal protein bS21 family
M4S28_03285	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
M4S28_03290	COG0596	Alpha beta hydrolase
M4S28_03295	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
M4S28_03300	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
M4S28_03305	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
M4S28_03310	COG1968	undecaprenyl-diphosphatase activity
M4S28_03315	COG0617	tRNA 3'-terminal CCA addition
M4S28_03320	COG3267	Type II secretory pathway component ExeA
M4S28_03320	COG3409	Peptidoglycan-binding domain 1 protein
M4S28_03330	COG4991	sh3 domain protein
M4S28_03335	COG0306	phosphate transporter
M4S28_03340	COG1392	Phosphate transport regulator
M4S28_03345	COG3025	triphosphatase activity
M4S28_03350	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
M4S28_03360	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
M4S28_03365	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
M4S28_03365	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
M4S28_03370	COG1538	Outer membrane efflux protein
M4S28_03375	COG0494	nUDIX hydrolase
M4S28_03380	COG3151	Protein conserved in bacteria
M4S28_03390	COG3150	esterase
M4S28_03395	COG0187	DNA topoisomerase II activity
M4S28_03405	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M4S28_03415	COG3105	Protein conserved in bacteria
M4S28_03420	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
M4S28_03425	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
M4S28_03430	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
M4S28_03435	COG0723	plastoquinol--plastocyanin reductase activity
M4S28_03440	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
M4S28_03445	COG2857	Cytochrome c1
M4S28_03450	COG0625	glutathione transferase activity
M4S28_03455	COG2969	positive regulation of protein catabolic process
M4S28_03465	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
M4S28_03480	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
M4S28_03490	COG0275	rRNA processing
M4S28_03495	COG3116	cell division
M4S28_03500	COG0768	penicillin binding
M4S28_03505	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
M4S28_03510	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
M4S28_03515	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
M4S28_03520	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
M4S28_03525	COG0772	Belongs to the SEDS family
M4S28_03530	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
M4S28_03535	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
M4S28_03540	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
M4S28_03545	COG0849	cell division
M4S28_03550	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
M4S28_03555	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
M4S28_03560	COG0653	protein targeting
M4S28_03565	COG0494	nUDIX hydrolase
M4S28_03570	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
M4S28_03575	COG0505	Belongs to the CarA family
M4S28_03580	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
M4S28_03585	COG0730	response to heat
M4S28_03590	COG0583	DNA-binding transcription factor activity
M4S28_03600	COG2860	membrane
M4S28_03605	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M4S28_03615	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
M4S28_03625	COG0493	'glutamate synthase
M4S28_03630	COG0067	glutamate synthase
M4S28_03630	COG0069	glutamate synthase activity
M4S28_03630	COG0070	glutamate synthase
M4S28_03640	COG0067	glutamate synthase
M4S28_03640	COG0069	glutamate synthase activity
M4S28_03640	COG0070	glutamate synthase
M4S28_03645	COG1242	4 iron, 4 sulfur cluster binding
M4S28_03650	COG5001	Diguanylate cyclase
M4S28_03650	COG4251	negative regulation of phosphorylation
M4S28_03650	COG3706	GGDEF domain
M4S28_03650	COG2203	Gaf domain
M4S28_03655	COG0784	Response regulator, receiver
M4S28_03655	COG2198	Histidine kinase
M4S28_03655	COG5002	protein histidine kinase activity
M4S28_03665	COG0745	RESPONSE REGULATOR receiver
M4S28_03670	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
M4S28_03685	COG0083	homoserine kinase activity
M4S28_03690	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
M4S28_03695	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
M4S28_03700	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
M4S28_03705	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
M4S28_03720	COG1115	amino acid carrier protein
M4S28_03730	COG3022	response to hydroperoxide
M4S28_03735	COG0513	Belongs to the DEAD box helicase family
M4S28_03740	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
M4S28_03750	COG0716	FMN binding
M4S28_03755	COG4974	Belongs to the 'phage' integrase family
M4S28_03760	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M4S28_03765	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
M4S28_03775	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
M4S28_03800	COG0494	nUDIX hydrolase
M4S28_03810	COG0730	response to heat
M4S28_03815	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
M4S28_03820	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
M4S28_03825	COG0745	RESPONSE REGULATOR receiver
M4S28_03835	COG1283	sodium-dependent phosphate transmembrane transporter activity
M4S28_03840	COG0583	DNA-binding transcription factor activity
M4S28_03845	COG0640	Transcriptional regulator
M4S28_03850	COG0268	Binds directly to 16S ribosomal RNA
M4S28_03855	COG0728	peptidoglycan biosynthetic process
M4S28_03860	COG0196	riboflavin kinase activity
M4S28_03865	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
M4S28_03875	COG1047	Peptidyl-prolyl cis-trans
M4S28_03880	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
M4S28_03885	COG3279	Response regulator of the LytR AlgR family
M4S28_03890	COG3275	phosphorelay sensor kinase activity
M4S28_03895	COG3385	transposase activity
M4S28_03900	COG1966	Carbon starvation protein
M4S28_03910	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
M4S28_03915	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
M4S28_03920	COG2971	BadF BadG BcrA BcrD
M4S28_03940	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
M4S28_03945	COG0287	Prephenate dehydrogenase
M4S28_03945	COG1605	Chorismate mutase
M4S28_03950	COG0739	heme binding
M4S28_03960	COG0488	(ABC) transporter
M4S28_03970	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
M4S28_03975	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
M4S28_03980	COG5001	Diguanylate cyclase
M4S28_03985	COG0077	Prephenate dehydratase
M4S28_03985	COG1605	Chorismate mutase
M4S28_03990	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
M4S28_03995	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
M4S28_04000	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
M4S28_04005	COG0564	pseudouridine synthase activity
M4S28_04050	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
M4S28_04060	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
M4S28_04065	COG0826	peptidase U32
M4S28_04070	COG2974	May be involved in recombination
M4S28_04075	COG0745	RESPONSE REGULATOR receiver
M4S28_04080	COG5002	protein histidine kinase activity
M4S28_04090	COG0248	Ppx GppA phosphatase
M4S28_04095	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
M4S28_04100	COG0573	inorganic phosphate transmembrane transporter activity
M4S28_04105	COG0581	inorganic phosphate transmembrane transporter activity
M4S28_04110	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
M4S28_04115	COG0704	Plays a role in the regulation of phosphate uptake
M4S28_04135	COG3142	Participates in the control of copper homeostasis
M4S28_04140	COG0450	alkyl hydroperoxide reductase
M4S28_04145	COG0583	DNA-binding transcription factor activity
M4S28_04150	COG0840	transmembrane signaling receptor activity
M4S28_04155	COG0517	IMP dehydrogenase activity
M4S28_04160	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
M4S28_04165	COG0343	queuine tRNA-ribosyltransferase activity
M4S28_04170	COG1862	Preprotein translocase
M4S28_04175	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
M4S28_04180	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
M4S28_04185	COG0483	inositol monophosphate 1-phosphatase activity
M4S28_04190	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
M4S28_04195	COG1959	2 iron, 2 sulfur cluster binding
M4S28_04200	COG1104	cysteine desulfurase activity
M4S28_04205	COG0822	iron-sulfur transferase activity
M4S28_04215	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
M4S28_04220	COG0443	Heat shock 70 kDa protein
M4S28_04230	COG2975	iron-sulfur cluster assembly
M4S28_04235	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
M4S28_04240	COG0105	UTP biosynthetic process
M4S28_04245	COG0820	rRNA (adenine-C2-)-methyltransferase activity
M4S28_04250	COG1426	Protein conserved in bacteria
M4S28_04255	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
M4S28_04260	COG0124	histidyl-tRNA synthetase
M4S28_04265	COG2976	Protein conserved in bacteria
M4S28_04270	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
M4S28_04275	COG1160	GTP binding
M4S28_04280	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
M4S28_04285	COG3706	GGDEF domain
M4S28_04325	COG0831	urea catabolic process
M4S28_04330	COG0832	Belongs to the urease beta subunit family
M4S28_04335	COG0804	urea catabolic process
M4S28_04340	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
M4S28_04355	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
M4S28_04360	COG1570	exodeoxyribonuclease VII activity
M4S28_04365	COG0516	GMP reductase activity
M4S28_04365	COG0517	IMP dehydrogenase activity
M4S28_04370	COG0519	Catalyzes the synthesis of GMP from XMP
M4S28_04370	COG0518	GMP synthase (glutamine-hydrolyzing) activity
M4S28_04380	COG1757	Na H antiporter
M4S28_04385	COG1584	GPR1 FUN34 yaaH family protein
M4S28_04390	COG1115	amino acid carrier protein
M4S28_04395	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
M4S28_04400	COG0204	Acyl-transferase
M4S28_04425	COG0189	ligase activity
M4S28_04425	COG4067	protein conserved in archaea
M4S28_04440	COG2867	negative regulation of translational initiation
M4S28_04445	COG2914	Belongs to the UPF0125 (RnfH) family
M4S28_04450	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
M4S28_04455	COG0497	DNA recombination
M4S28_04460	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
M4S28_04465	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
M4S28_04480	COG3385	transposase activity
M4S28_04485	COG0443	Heat shock 70 kDa protein
M4S28_04490	COG0484	heat shock protein binding
M4S28_04520	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
M4S28_04525	COG1253	flavin adenine dinucleotide binding
M4S28_04540	COG0047	phosphoribosylformylglycinamidine synthase activity
M4S28_04540	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
M4S28_04550	COG2171	N-acyltransferase activity
M4S28_04555	COG0737	Belongs to the 5'-nucleotidase family
M4S28_04560	COG2095	MarC family integral membrane protein
M4S28_04575	COG3141	response to X-ray
M4S28_04590	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
M4S28_04600	COG1074	ATP-dependent DNA helicase activity
M4S28_04605	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
M4S28_04615	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
M4S28_04615	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
M4S28_04625	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
M4S28_04630	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
M4S28_04635	COG2166	iron-sulfur cluster assembly
M4S28_04640	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
M4S28_04645	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
M4S28_04660	COG2211	Major facilitator Superfamily
M4S28_04665	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
M4S28_04675	COG2813	Specifically methylates the guanine in position
M4S28_04680	COG0271	Belongs to the BolA IbaG family
M4S28_04685	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
M4S28_04690	COG1805	sodium ion transport
M4S28_04700	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
M4S28_04705	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
M4S28_04710	COG2871	sodium ion transport
M4S28_04715	COG1477	protein flavinylation
M4S28_04720	COG2991	Protein conserved in bacteria
M4S28_04730	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
M4S28_04735	COG0840	transmembrane signaling receptor activity
M4S28_04755	COG0733	neurotransmitter:sodium symporter activity
M4S28_04760	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
M4S28_04765	COG0321	lipoyl(octanoyl) transferase activity
M4S28_04775	COG1686	Belongs to the peptidase S11 family
M4S28_04780	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
M4S28_04785	COG0772	Belongs to the SEDS family
M4S28_04790	COG0768	penicillin binding
M4S28_04795	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
M4S28_04800	COG0799	negative regulation of ribosome biogenesis
M4S28_04805	COG1466	dna polymerase III delta subunit
M4S28_04810	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
M4S28_04815	COG0495	leucyl-tRNA aminoacylation
M4S28_04820	COG2888	peptidyl-tyrosine sulfation
M4S28_04825	COG0815	Transfers the fatty acyl group on membrane lipoproteins
M4S28_04830	COG4535	Mg2 and Co2 transporter CorC
M4S28_04835	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
M4S28_04840	COG1702	phosphate starvation-inducible protein PhoH
M4S28_04850	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M4S28_04855	COG2706	6-phosphogluconolactonase activity
M4S28_04960	COG0193	aminoacyl-tRNA hydrolase activity
M4S28_04965	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
M4S28_04970	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
M4S28_04975	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
M4S28_04980	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
M4S28_04985	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
M4S28_04990	COG2890	protein-(glutamine-N5) methyltransferase activity
M4S28_04995	COG3094	Invasion gene expression up-regulator, SirB
M4S28_05000	COG2912	Transglutaminase-like superfamily
M4S28_05005	COG2877	3-deoxy-8-phosphooctulonate synthase activity
M4S28_05015	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
M4S28_05020	COG1187	pseudouridine synthase activity
M4S28_05025	COG2840	Smr protein MutS2
M4S28_05065	COG2608	mercury ion transmembrane transporter activity
M4S28_05065	COG2217	Heavy metal translocating P-type atpase
M4S28_05080	COG1028	Short-chain dehydrogenase reductase Sdr
M4S28_05120	COG1216	Glycosyl transferase, family 2
M4S28_05140	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M4S28_05145	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M4S28_05205	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
M4S28_05210	COG0784	Response regulator, receiver
M4S28_05210	COG0835	chemotaxis
M4S28_05215	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
M4S28_05220	COG1815	bacterial-type flagellum-dependent cell motility
M4S28_05225	COG1558	bacterial-type flagellum-dependent cell motility
M4S28_05235	COG1749	Flagellar hook protein flgE
M4S28_05240	COG4787	bacterial-type flagellum-dependent cell motility
M4S28_05250	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
M4S28_05255	COG1706	bacterial-type flagellum-dependent cell motility
M4S28_05260	COG1705	Flagellar rod assembly protein muramidase FlgJ
M4S28_05260	COG3951	Flagellar rod assembly protein muramidase FlgJ
M4S28_05275	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
M4S28_05285	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
M4S28_05290	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
M4S28_05300	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
M4S28_05310	COG1516	flagellar protein fliS
M4S28_05330	COG1677	Flagellar hook-basal body complex protein FliE
M4S28_05340	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
M4S28_05390	COG1987	bacterial-type flagellum assembly
M4S28_05395	COG1684	flagellar biosynthetic protein fliR
M4S28_05430	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
M4S28_05435	COG0643	Histidine kinase
M4S28_05435	COG0784	Response regulator, receiver
M4S28_05435	COG2198	Histidine kinase
M4S28_05440	COG2201	protein-glutamate methylesterase activity
M4S28_05445	COG1192	Involved in chromosome partitioning
M4S28_05455	COG0835	chemotaxis
M4S28_05465	COG4133	protoheme IX ABC transporter activity
M4S28_05470	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
M4S28_05475	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
M4S28_05480	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
M4S28_05485	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
M4S28_05490	COG1138	Cytochrome C-type biogenesis protein
M4S28_05495	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M4S28_05505	COG4235	cytochrome complex assembly
M4S28_05505	COG3088	subunit of a heme lyase
M4S28_05515	COG2067	long-chain fatty acid transport protein
M4S28_05535	COG0183	Belongs to the thiolase family
M4S28_05540	COG1024	Enoyl-CoA hydratase
M4S28_05540	COG1250	3-hydroxyacyl-CoA dehydrogenase
M4S28_05550	COG2062	phosphohistidine phosphatase, SixA
M4S28_05555	COG2840	Smr protein MutS2
M4S28_05560	COG2890	protein-(glutamine-N5) methyltransferase activity
M4S28_05565	COG1280	lysine exporter protein (LysE YggA)
M4S28_05570	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
M4S28_05590	COG1175	transmembrane transport
M4S28_05600	COG3842	ATPase activity
M4S28_05610	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
M4S28_05615	COG2070	2-Nitropropane dioxygenase
M4S28_05615	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
M4S28_05630	COG3321	synthase
M4S28_05630	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M4S28_05645	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
M4S28_05650	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
M4S28_05655	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
M4S28_05665	COG2204	response regulator
M4S28_05675	COG0544	peptidyl-prolyl cis-trans isomerase activity
M4S28_05680	COG0740	serine-type endopeptidase activity
M4S28_05685	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
M4S28_05690	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
M4S28_05695	COG0776	regulation of translation
M4S28_05700	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M4S28_05705	COG1555	photosystem II stabilization
M4S28_05720	COG0232	Belongs to the dGTPase family. Type 2 subfamily
M4S28_05725	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
M4S28_05730	COG0436	Aminotransferase
M4S28_05735	COG1169	isochorismate synthase
M4S28_05740	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
M4S28_05745	COG2267	carboxylic ester hydrolase activity
M4S28_05750	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
M4S28_05770	COG2855	membrane
M4S28_05835	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M4S28_05845	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
M4S28_05850	COG1522	sequence-specific DNA binding
M4S28_05860	COG1946	Acyl-CoA thioesterase
M4S28_05865	COG3126	Type III secretion system lipoprotein chaperone (YscW)
M4S28_05885	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
M4S28_05885	COG2169	Transcriptional regulator
M4S28_05915	COG3152	Membrane
M4S28_05925	COG0328	RNA-DNA hybrid ribonuclease activity
M4S28_05925	COG3341	Caulimovirus viroplasmin
M4S28_05930	COG0438	transferase activity, transferring glycosyl groups
M4S28_05935	COG1216	Glycosyl transferase, family 2
M4S28_05935	COG0463	Glycosyl transferase, family 2
M4S28_05975	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
M4S28_06000	COG0069	glutamate synthase activity
M4S28_06010	COG1250	3-hydroxyacyl-CoA dehydrogenase
M4S28_06010	COG1024	Enoyl-CoA hydratase
M4S28_06015	COG0583	DNA-binding transcription factor activity
M4S28_06020	COG0789	Transcriptional regulator
M4S28_06030	COG1486	melibiose metabolic process
M4S28_06035	COG0583	DNA-binding transcription factor activity
M4S28_06060	COG3119	arylsulfatase activity
M4S28_06065	COG1609	Transcriptional regulator
M4S28_06080	COG2814	Major facilitator Superfamily
M4S28_06090	COG1760	l-serine dehydratase
M4S28_06095	COG1522	sequence-specific DNA binding
M4S28_06100	COG1280	lysine exporter protein (LysE YggA)
M4S28_06120	COG2233	PERMEase
M4S28_06125	COG0583	DNA-binding transcription factor activity
M4S28_06130	COG1028	Short-chain dehydrogenase reductase Sdr
M4S28_06135	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
M4S28_06150	COG1227	inorganic diphosphatase activity
M4S28_06165	COG0583	DNA-binding transcription factor activity
M4S28_06190	COG0446	pyridine nucleotide-disulphide oxidoreductase
M4S28_06200	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
M4S28_06215	COG1228	amidohydrolase
M4S28_06230	COG3040	lipid binding
M4S28_06245	COG0583	DNA-binding transcription factor activity
M4S28_06250	COG1309	transcriptional regulator
M4S28_06260	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M4S28_06265	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
M4S28_06270	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
M4S28_06275	COG1845	cytochrome c oxidase, subunit III
M4S28_06280	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
M4S28_06295	COG2015	COG2015, Alkyl sulfatase and related hydrolases
M4S28_06315	COG0583	DNA-binding transcription factor activity
M4S28_06320	COG0346	lactoylglutathione lyase activity
M4S28_06325	COG1902	pentaerythritol trinitrate reductase activity
M4S28_06340	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
M4S28_06345	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M4S28_06375	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
M4S28_06375	COG0517	IMP dehydrogenase activity
M4S28_06375	COG0617	tRNA 3'-terminal CCA addition
M4S28_06405	COG0537	adenosine 5'-monophosphoramidase activity
M4S28_06430	COG3150	esterase
M4S28_06435	COG1252	NADH dehydrogenase
M4S28_06450	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
M4S28_06460	COG4591	ABC-type transport system involved in lipoprotein release permease component
M4S28_06465	COG1136	(ABC) transporter
M4S28_06470	COG4591	ABC-type transport system involved in lipoprotein release permease component
M4S28_06480	COG2333	competence protein COMEC
M4S28_06480	COG0658	competence protein
M4S28_06485	COG1132	(ABC) transporter
M4S28_06490	COG1663	tetraacyldisaccharide 4'-kinase activity
M4S28_06495	COG2835	tetraacyldisaccharide 4'-kinase activity
M4S28_06500	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
M4S28_06505	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
M4S28_06510	COG0539	negative regulation of cytoplasmic translation
M4S28_06515	COG0776	regulation of translation
M4S28_06520	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
M4S28_06525	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
M4S28_06530	COG0284	orotidine-5'-phosphate decarboxylase activity
M4S28_06545	COG0583	DNA-binding transcription factor activity
M4S28_06555	COG0686	Belongs to the AlaDH PNT family
M4S28_06560	COG1522	sequence-specific DNA binding
M4S28_06565	COG1674	ftsk spoiiie
M4S28_06570	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
M4S28_06575	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
M4S28_06580	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
M4S28_06585	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
M4S28_06590	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
M4S28_06595	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
M4S28_06600	COG0156	8-amino-7-oxononanoate synthase activity
M4S28_06620	COG0501	Belongs to the peptidase M48B family
M4S28_06625	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
M4S28_06630	COG2915	High frequency lysogenization protein hflD homolog
M4S28_06645	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M4S28_06650	COG2916	Histone family protein nucleoid-structuring protein H-NS
M4S28_06655	COG1757	Na H antiporter
M4S28_06670	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
M4S28_06675	COG0131	Imidazoleglycerol-phosphate dehydratase
M4S28_06675	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
M4S28_06680	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
M4S28_06685	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
M4S28_06690	COG0107	imidazoleglycerol-phosphate synthase activity
M4S28_06695	COG0140	phosphoribosyl-ATP diphosphatase activity
M4S28_06695	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
M4S28_06700	COG3012	SEC-C Motif Domain Protein
M4S28_06705	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
M4S28_06710	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M4S28_06715	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
M4S28_06720	COG0215	cysteine-tRNA ligase activity
M4S28_06750	COG2116	formate transmembrane transporter activity
M4S28_06785	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
M4S28_06800	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
M4S28_06815	COG0390	transport system, permease component
M4S28_06820	COG4459	periplasmic nitrate reductase
M4S28_06825	COG3005	denitrification pathway
M4S28_06830	COG0243	molybdopterin cofactor binding
M4S28_06840	COG1227	inorganic diphosphatase activity
M4S28_06855	COG4172	Belongs to the ABC transporter superfamily
M4S28_06870	COG4168	peptide transport system, permease
M4S28_06875	COG4166	transmembrane transport
M4S28_06880	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
M4S28_06885	COG1842	Phage shock protein A
M4S28_06895	COG1983	PspC domain protein
M4S28_06915	COG2818	Glycosylase
M4S28_06930	COG0626	cystathionine gamma-synthase activity
M4S28_06940	COG0733	neurotransmitter:sodium symporter activity
M4S28_06950	COG0564	pseudouridine synthase activity
M4S28_06955	COG0116	Belongs to the methyltransferase superfamily
M4S28_06955	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
M4S28_06960	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
M4S28_06965	COG4136	ATPase activity
M4S28_06970	COG4135	transport system, permease component
M4S28_06975	COG4134	Bacterial extracellular solute-binding protein
M4S28_06985	COG3313	Fe-S protein
M4S28_07005	COG0513	Belongs to the DEAD box helicase family
M4S28_07010	COG1280	lysine exporter protein (LysE YggA)
M4S28_07020	COG2866	Carboxypeptidase
M4S28_07045	COG4176	ABC-type proline glycine betaine transport system permease component
M4S28_07050	COG2113	Glycine betaine
M4S28_07060	COG0583	DNA-binding transcription factor activity
M4S28_07065	COG2995	paraquat-inducible protein a
M4S28_07070	COG3008	intermembrane lipid transfer
M4S28_07070	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
M4S28_07130	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M4S28_07140	COG0641	radical SAM
M4S28_07150	COG3119	arylsulfatase activity
M4S28_07170	COG2211	Major facilitator Superfamily
M4S28_07310	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
M4S28_07320	COG0586	Pfam SNARE associated Golgi protein
M4S28_07330	COG0642	Histidine kinase
M4S28_07345	COG1061	Type III restriction enzyme res subunit
M4S28_07355	COG2814	Major facilitator Superfamily
M4S28_07365	COG0702	epimerase
M4S28_07370	COG0534	Mate efflux family protein
M4S28_07375	COG1136	(ABC) transporter
M4S28_07390	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
M4S28_07425	COG2985	domain, Protein
M4S28_07425	COG3273	potassium ion transport
M4S28_07430	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
M4S28_07440	COG1737	Transcriptional regulator
M4S28_07445	COG0076	glutamate decarboxylase activity
M4S28_07455	COG2431	L-lysine efflux transmembrane transporter activity
M4S28_07465	COG3070	regulator of competence-specific genes
M4S28_07475	COG2204	response regulator
M4S28_07480	COG3852	Histidine kinase
M4S28_07490	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
M4S28_07500	COG2258	MOSC domain
M4S28_07505	COG2176	DNA-directed DNA polymerase activity
M4S28_07520	COG1448	Aminotransferase
M4S28_07525	COG2770	Histidine kinase
M4S28_07525	COG3437	response regulator, receiver
M4S28_07535	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M4S28_07555	COG0017	Asparaginyl-tRNA synthetase
M4S28_07560	COG0659	secondary active sulfate transmembrane transporter activity
M4S28_07565	COG0840	transmembrane signaling receptor activity
M4S28_07575	COG0583	DNA-binding transcription factor activity
M4S28_07580	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
M4S28_07590	COG0814	amino acid
M4S28_07595	COG1760	l-serine dehydratase
M4S28_07600	COG0814	amino acid
M4S28_07605	COG0494	nUDIX hydrolase
M4S28_07615	COG2205	protein histidine kinase activity
M4S28_07615	COG0784	Response regulator, receiver
M4S28_07635	COG3106	COG3106 Predicted ATPase
M4S28_07650	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M4S28_07665	COG0443	Heat shock 70 kDa protein
M4S28_07680	COG3706	GGDEF domain
M4S28_07700	COG3710	Transcriptional regulator
M4S28_07730	COG1643	Atp-dependent helicase
M4S28_07775	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
M4S28_07780	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M4S28_07780	COG0072	phenylalanine-tRNA ligase activity
M4S28_07865	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
M4S28_07870	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
M4S28_07875	COG2356	endonuclease I
M4S28_07925	COG1522	sequence-specific DNA binding
M4S28_07930	COG2873	o-acetylhomoserine
M4S28_07940	COG0697	spore germination
M4S28_07965	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
M4S28_07970	COG0583	DNA-binding transcription factor activity
M4S28_08000	COG1289	transmembrane transporter activity
M4S28_08015	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
M4S28_08035	COG2205	protein histidine kinase activity
M4S28_08050	COG1342	Belongs to the UPF0251 family
M4S28_08075	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
M4S28_08100	COG0776	regulation of translation
M4S28_08105	COG3961	Belongs to the TPP enzyme family
M4S28_08165	COG0840	transmembrane signaling receptor activity
M4S28_08175	COG0583	DNA-binding transcription factor activity
M4S28_08185	COG2175	clavaminate synthase activity
M4S28_08200	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M4S28_08215	COG0523	cobalamin synthesis protein
M4S28_08230	COG0776	regulation of translation
M4S28_08260	COG0500	methyltransferase
M4S28_08265	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
M4S28_08270	COG0295	cytidine deaminase activity
M4S28_08275	COG1346	cytolysis
M4S28_08285	COG2925	Exonuclease
M4S28_08330	COG3568	Endonuclease Exonuclease Phosphatase
M4S28_08335	COG3122	Protein conserved in bacteria
M4S28_08370	COG4989	oxidoreductase activity
M4S28_08380	COG1823	symporter activity
M4S28_08385	COG0702	epimerase
M4S28_08390	COG2165	general secretion pathway protein
M4S28_08395	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
M4S28_08400	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
M4S28_08405	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
M4S28_08425	COG2988	succinylglutamate desuccinylase activity
M4S28_08430	COG4139	cobalamin transport
M4S28_08435	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
M4S28_08445	COG0583	DNA-binding transcription factor activity
M4S28_08465	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M4S28_08470	COG1271	oxidase subunit
M4S28_08475	COG1294	oxidase, subunit
M4S28_08520	COG1247	-acetyltransferase
M4S28_08540	COG2814	Major facilitator Superfamily
M4S28_08545	COG0583	DNA-binding transcription factor activity
M4S28_08555	COG1451	nucleotide metabolic process
M4S28_08565	COG3063	Type IV pilus biogenesis stability protein PilW
M4S28_08570	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
M4S28_08585	COG2195	Cleaves the N-terminal amino acid of tripeptides
M4S28_08590	COG3706	GGDEF domain
M4S28_08610	COG0582	viral genome integration into host DNA
M4S28_08625	COG4983	Phage plasmid primase, P4 family domain protein
M4S28_08660	COG2003	Belongs to the UPF0758 family
M4S28_08695	COG0514	ATP-dependent DNA helicase (RecQ)
M4S28_08725	COG1484	DNA-dependent DNA replication
M4S28_08730	COG4584	PFAM Integrase catalytic
M4S28_08740	COG0583	DNA-binding transcription factor activity
M4S28_08760	COG4964	Belongs to the GSP D family
M4S28_08770	COG0455	bacterial-type flagellum organization
M4S28_08815	COG5001	Diguanylate cyclase
M4S28_08815	COG5002	protein histidine kinase activity
M4S28_08820	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
M4S28_08825	COG0583	DNA-binding transcription factor activity
M4S28_08840	COG0840	transmembrane signaling receptor activity
M4S28_08855	COG3469	chitinase activity
M4S28_08865	COG4771	TonB-dependent receptor
M4S28_08870	COG2226	methyltransferase
M4S28_08875	COG3706	GGDEF domain
M4S28_08880	COG0454	-acetyltransferase
M4S28_08910	COG0420	3'-5' exonuclease activity
M4S28_08915	COG0419	ATPase involved in DNA repair
M4S28_08935	COG3046	protein related to deoxyribodipyrimidine photolyase
M4S28_08940	COG0415	Belongs to the DNA photolyase family
M4S28_08945	COG0589	response to stress
M4S28_08975	COG2271	Major facilitator Superfamily
M4S28_08980	COG0584	glycerophosphoryl diester phosphodiesterase
M4S28_08990	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
M4S28_09010	COG0494	nUDIX hydrolase
M4S28_09025	COG1187	pseudouridine synthase activity
M4S28_09035	COG0110	maltose O-acetyltransferase activity
M4S28_09085	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
M4S28_09110	COG0494	nUDIX hydrolase
M4S28_09155	COG0346	lactoylglutathione lyase activity
M4S28_09185	COG1619	proteins homologs of microcin C7 resistance protein MccF
M4S28_09205	COG0653	protein targeting
M4S28_09210	COG0546	phosphoglycolate phosphatase activity
M4S28_09220	COG1028	Short-chain dehydrogenase reductase Sdr
M4S28_09255	COG0786	glutamate:sodium symporter activity
M4S28_09270	COG0826	peptidase U32
M4S28_09285	COG1126	abc transporter atp-binding protein
M4S28_09290	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M4S28_09295	COG4215	(ABC) transporter
M4S28_09300	COG4160	amino acid transport
M4S28_09310	COG0517	IMP dehydrogenase activity
M4S28_09375	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
M4S28_09425	COG0583	DNA-binding transcription factor activity
M4S28_09430	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
M4S28_09465	COG0438	transferase activity, transferring glycosyl groups
M4S28_09470	COG2204	response regulator
M4S28_09480	COG3448	diguanylate cyclase activity
M4S28_09480	COG4175	Glycine betaine
M4S28_09485	COG4176	ABC-type proline glycine betaine transport system permease component
M4S28_09495	COG4999	Histidine kinase
M4S28_09495	COG3437	response regulator, receiver
M4S28_09495	COG3850	Histidine kinase
M4S28_09495	COG2205	protein histidine kinase activity
M4S28_09515	COG2885	chlorophyll binding
M4S28_09525	COG1793	dna ligase
M4S28_09530	COG0534	Mate efflux family protein
M4S28_09535	COG0307	riboflavin synthase, alpha
M4S28_09545	COG3001	Fructosamine kinase
M4S28_09555	COG0791	NLP P60 protein
M4S28_09570	COG3148	PFAM DTW domain containing protein
M4S28_09575	COG1940	carbohydrate kinase activity
M4S28_09585	COG0303	'Molybdopterin
M4S28_09590	COG0746	molybdenum cofactor guanylyltransferase activity
M4S28_09595	COG3842	ATPase activity
M4S28_09600	COG4662	Binding-protein-dependent transport system inner membrane component
M4S28_09615	COG4191	Histidine kinase
M4S28_09620	COG0840	transmembrane signaling receptor activity
M4S28_09635	COG0488	(ABC) transporter
M4S28_09640	COG0840	transmembrane signaling receptor activity
M4S28_09645	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
M4S28_09665	COG3381	protein complex oligomerization
M4S28_09675	COG0243	molybdopterin cofactor binding
M4S28_09675	COG3383	formate dehydrogenase (NAD+) activity
M4S28_09680	COG0437	4 iron, 4 sulfur cluster binding
M4S28_09695	COG0004	ammonium transporteR
M4S28_09700	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
M4S28_09710	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
M4S28_09720	COG1177	transmembrane transport
M4S28_09730	COG3842	ATPase activity
M4S28_09750	COG0037	tRNA processing
M4S28_09755	COG0589	response to stress
M4S28_09760	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M4S28_09775	COG2217	Heavy metal translocating P-type atpase
M4S28_09785	COG2010	Cytochrome c
M4S28_09800	COG3278	Belongs to the heme-copper respiratory oxidase family
M4S28_09815	COG0784	Response regulator, receiver
M4S28_09815	COG5002	protein histidine kinase activity
M4S28_09835	COG4128	Pfam Zonular occludens toxin
M4S28_09895	COG4128	Pfam Zonular occludens toxin
M4S28_09955	COG4128	Pfam Zonular occludens toxin
M4S28_10015	COG4128	Pfam Zonular occludens toxin
M4S28_10145	COG3120	sequence-specific DNA binding
M4S28_10150	COG1067	ATP-dependent peptidase activity
M4S28_10170	COG0488	(ABC) transporter
M4S28_10180	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
M4S28_10180	COG0116	Belongs to the methyltransferase superfamily
M4S28_10190	COG0167	dihydroorotate dehydrogenase activity
M4S28_10195	COG2902	Dehydrogenase
M4S28_10205	COG0308	aminopeptidase N
M4S28_10220	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
M4S28_10225	COG1956	GAF domain-containing protein
M4S28_10230	COG1132	(ABC) transporter
M4S28_10235	COG2995	paraquat-inducible protein a
M4S28_10240	COG3008	intermembrane lipid transfer
M4S28_10245	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
M4S28_10245	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
M4S28_10250	COG2996	Protein conserved in bacteria
M4S28_10265	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
M4S28_10265	COG0574	Belongs to the PEP-utilizing enzyme family
M4S28_10270	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
M4S28_10275	COG1666	GTP binding
M4S28_10285	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M4S28_10290	COG4597	amino acid ABC transporter
M4S28_10295	COG0765	amino acid transport
M4S28_10300	COG1126	abc transporter atp-binding protein
M4S28_10305	COG0670	Belongs to the BI1 family
M4S28_10310	COG2920	part of a sulfur-relay system
M4S28_10315	COG1254	Belongs to the acylphosphatase family
M4S28_10320	COG0840	transmembrane signaling receptor activity
M4S28_10345	COG2885	chlorophyll binding
M4S28_10355	COG3706	GGDEF domain
M4S28_10360	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
M4S28_10365	COG0602	queuosine metabolic process
M4S28_10370	COG0561	phosphatase activity
M4S28_10400	COG2828	Protein conserved in bacteria
M4S28_10405	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
M4S28_10410	COG0372	Belongs to the citrate synthase family
M4S28_10415	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
M4S28_10425	COG2814	Major facilitator Superfamily
M4S28_10435	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
M4S28_10540	COG0515	serine threonine protein kinase
M4S28_10540	COG2815	serine threonine protein kinase
M4S28_10585	COG4628	conserved protein (DUF2132)
M4S28_10595	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
M4S28_10600	COG0363	glucosamine-6-phosphate deaminase activity
M4S28_10605	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
M4S28_10610	COG4565	transcriptional regulatory protein
M4S28_10615	COG3290	protein histidine kinase activity
M4S28_10630	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M4S28_10645	COG1115	amino acid carrier protein
M4S28_10665	COG1115	amino acid carrier protein
M4S28_10685	COG1280	lysine exporter protein (LysE YggA)
M4S28_10690	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
M4S28_10720	COG0730	response to heat
M4S28_10795	COG0471	metal ion transport
M4S28_10875	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M4S28_10885	COG0840	transmembrane signaling receptor activity
M4S28_10895	COG2176	DNA-directed DNA polymerase activity
M4S28_10900	COG0517	IMP dehydrogenase activity
M4S28_10905	COG2186	Transcriptional regulator
M4S28_10910	COG1028	Short-chain dehydrogenase reductase Sdr
M4S28_10915	COG2186	Transcriptional regulator
M4S28_10945	COG0840	transmembrane signaling receptor activity
M4S28_10960	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M4S28_10965	COG2186	Transcriptional regulator
M4S28_10985	COG1917	Cupin 2, conserved barrel domain protein
M4S28_10990	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M4S28_10995	COG0800	Aldolase
M4S28_11000	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M4S28_11005	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
M4S28_11020	COG0010	Belongs to the arginase family
M4S28_11025	COG1166	arginine decarboxylase activity
M4S28_11035	COG1309	transcriptional regulator
M4S28_11040	COG0488	(ABC) transporter
M4S28_11055	COG3097	Belongs to the UPF0267 family
M4S28_11060	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
M4S28_11065	COG0291	Belongs to the bacterial ribosomal protein bL35 family
M4S28_11075	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
M4S28_11080	COG4326	sporulation control protein
M4S28_11090	COG1228	amidohydrolase
M4S28_11095	COG0010	Belongs to the arginase family
M4S28_11100	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
M4S28_11105	COG2986	histidine ammonia-lyase
M4S28_11120	COG0277	FAD linked oxidase domain protein
M4S28_11120	COG0247	lactate metabolic process
M4S28_11155	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
M4S28_11165	COG1643	Atp-dependent helicase
M4S28_11175	COG2949	membrane
M4S28_11180	COG0471	metal ion transport
M4S28_11200	COG2199	diguanylate cyclase activity
M4S28_11200	COG2203	Gaf domain
M4S28_11215	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
M4S28_11240	COG0492	ferredoxin-NADP+ reductase activity
M4S28_11245	COG4988	ABC transporter
M4S28_11250	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
M4S28_11280	COG2199	diguanylate cyclase activity
M4S28_11280	COG2202	Pas domain
M4S28_11280	COG2200	EAL domain
M4S28_11290	COG0457	Tetratricopeptide repeat
M4S28_11290	COG3710	Transcriptional regulator
M4S28_11295	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
M4S28_11305	COG0840	transmembrane signaling receptor activity
M4S28_11310	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M4S28_11315	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M4S28_11340	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
M4S28_11355	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M4S28_11360	COG3108	Peptidase M15
M4S28_11365	COG2989	Protein conserved in bacteria
M4S28_11390	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
M4S28_11400	COG4235	cytochrome complex assembly
M4S28_11400	COG3088	subunit of a heme lyase
M4S28_11410	COG1138	Cytochrome C-type biogenesis protein
M4S28_11415	COG3301	Polysulphide reductase, NrfD
M4S28_11420	COG0437	4 iron, 4 sulfur cluster binding
M4S28_11425	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
M4S28_11430	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
M4S28_11435	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
M4S28_11450	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
M4S28_11455	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M4S28_11460	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M4S28_11480	COG0243	molybdopterin cofactor binding
M4S28_11485	COG0437	4 iron, 4 sulfur cluster binding
M4S28_11490	COG3302	dmso reductase anchor subunit
M4S28_11510	COG0019	diaminopimelate decarboxylase activity
M4S28_11550	COG0322	excinuclease ABC activity
M4S28_11555	COG2197	response regulator
M4S28_11560	COG0417	DNA replication proofreading
M4S28_11570	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
M4S28_11585	COG1187	pseudouridine synthase activity
M4S28_11590	COG0009	L-threonylcarbamoyladenylate synthase
M4S28_11595	COG0613	PHP domain protein
M4S28_11605	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
M4S28_11610	COG0512	Glutamine amidotransferase of anthranilate synthase
M4S28_11615	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
M4S28_11620	COG0135	phosphoribosylanthranilate isomerase activity
M4S28_11620	COG0134	indole-3-glycerol-phosphate synthase activity
M4S28_11625	COG0133	tryptophan synthase activity
M4S28_11630	COG0159	tryptophan synthase activity
M4S28_11635	COG0330	HflC and HflK could
M4S28_11645	COG1301	dicarboxylic acid transport
M4S28_11655	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
M4S28_11670	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
M4S28_11685	COG2917	probably involved in intracellular septation
M4S28_11690	COG1607	acyl-coa hydrolase
M4S28_11695	COG2350	Protein conserved in bacteria
M4S28_11705	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
M4S28_11710	COG0583	DNA-binding transcription factor activity
M4S28_11725	COG1032	radical SAM domain protein
M4S28_11740	COG0463	Glycosyl transferase, family 2
M4S28_11745	COG0745	RESPONSE REGULATOR receiver
M4S28_11765	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M4S28_11770	COG0583	DNA-binding transcription factor activity
M4S28_11785	COG5002	protein histidine kinase activity
M4S28_11785	COG0784	Response regulator, receiver
M4S28_11800	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
M4S28_11805	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
M4S28_11810	COG2885	chlorophyll binding
M4S28_11815	COG0823	Involved in the tonB-independent uptake of proteins
M4S28_11830	COG0811	peptide transport
M4S28_11835	COG0824	Thioesterase
M4S28_11845	COG4890	Cyd operon protein YbgT
M4S28_11850	COG1294	oxidase, subunit
M4S28_11855	COG1271	oxidase subunit
M4S28_11860	COG2255	four-way junction helicase activity
M4S28_11865	COG0632	four-way junction helicase activity
M4S28_11870	COG0840	transmembrane signaling receptor activity
M4S28_11875	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
M4S28_11880	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
M4S28_11885	COG1801	Protein of unknown function DUF72
M4S28_11890	COG4106	trans-aconitate 2-methyltransferase activity
M4S28_11895	COG0500	methyltransferase
M4S28_11900	COG4067	protein conserved in archaea
M4S28_11900	COG0189	ligase activity
M4S28_11915	COG3383	formate dehydrogenase (NAD+) activity
M4S28_11920	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
M4S28_11925	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
M4S28_11930	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
M4S28_11935	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
M4S28_11940	COG1434	Gram-negative-bacterium-type cell wall biogenesis
M4S28_11945	COG0745	RESPONSE REGULATOR receiver
M4S28_11950	COG3381	protein complex oligomerization
M4S28_11955	COG1609	Transcriptional regulator
M4S28_11960	COG3070	regulator of competence-specific genes
M4S28_11985	COG0297	glycogen (starch) synthase activity
M4S28_11990	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
M4S28_11995	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
M4S28_12005	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
M4S28_12015	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
M4S28_12020	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
M4S28_12025	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
M4S28_12030	COG0542	response to heat
M4S28_12035	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
M4S28_12040	COG1278	Cold shock
M4S28_12050	COG1187	pseudouridine synthase activity
M4S28_12065	COG1199	ATP-dependent helicase activity
M4S28_12070	COG0730	response to heat
M4S28_12085	COG2850	peptidyl-arginine hydroxylation
M4S28_12090	COG0840	transmembrane signaling receptor activity
M4S28_12095	COG2814	Major facilitator Superfamily
M4S28_12100	COG1770	oligopeptidase
M4S28_12105	COG0708	Exodeoxyribonuclease III
M4S28_12110	COG4160	amino acid transport
M4S28_12135	COG1882	Formate acetyltransferase
M4S28_12145	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
M4S28_12150	COG3013	Belongs to the UPF0304 family
M4S28_12155	COG3713	MltA-interacting MipA family protein
M4S28_12160	COG2766	serine protein kinase
M4S28_12165	COG2718	Belongs to the UPF0229 family
M4S28_12170	COG2719	SpoVR family
M4S28_12175	COG0616	signal peptide processing
M4S28_12180	COG1028	Short-chain dehydrogenase reductase Sdr
M4S28_12185	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
M4S28_12200	COG0784	Response regulator, receiver
M4S28_12200	COG0835	chemotaxis
M4S28_12205	COG1940	carbohydrate kinase activity
M4S28_12210	COG0469	pyruvate kinase activity
M4S28_12215	COG4667	esterase of the alpha-beta hydrolase superfamily
M4S28_12235	COG1263	PTS System
M4S28_12235	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M4S28_12240	COG0084	hydrolase, TatD family'
M4S28_12255	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
M4S28_12260	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
M4S28_12285	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
M4S28_12290	COG0416	fatty acid biosynthetic process
M4S28_12295	COG0333	Belongs to the bacterial ribosomal protein bL32 family
M4S28_12300	COG1399	metal-binding, possibly nucleic acid-binding protein
M4S28_12310	COG0564	pseudouridine synthase activity
M4S28_12315	COG1530	ribonuclease E activity
M4S28_12320	COG0659	secondary active sulfate transmembrane transporter activity
M4S28_12330	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
M4S28_12335	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
M4S28_12340	COG2982	Protein involved in outer membrane biogenesis
M4S28_12345	COG0572	uridine kinase
M4S28_12350	COG0489	protein tyrosine kinase activity
M4S28_12355	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M4S28_12355	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M4S28_12365	COG2186	Transcriptional regulator
M4S28_12370	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
M4S28_12380	COG0653	protein targeting
M4S28_12385	COG2165	general secretion pathway protein
M4S28_12390	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
M4S28_12395	COG3706	GGDEF domain
M4S28_12400	COG0366	Alpha amylase catalytic
M4S28_12410	COG3092	negative regulation of chromosome organization
M4S28_12415	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
M4S28_12420	COG0280	phosphate acetyltransferase
M4S28_12420	COG0857	belongs to the CobB CobQ family
M4S28_12425	COG0435	Glutathione S-transferase
M4S28_12435	COG0444	Belongs to the ABC transporter superfamily
M4S28_12440	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M4S28_12445	COG0601	transmembrane transport
M4S28_12455	COG0314	molybdopterin synthase activity
M4S28_12460	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
M4S28_12465	COG0315	cyclic pyranopterin monophosphate synthase activity
M4S28_12470	COG0521	Mo-molybdopterin cofactor biosynthetic process
M4S28_12475	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
M4S28_12480	COG0391	Required for morphogenesis under gluconeogenic growth conditions
M4S28_12485	COG2198	Histidine kinase
M4S28_12490	COG2204	response regulator
M4S28_12495	COG0556	nucleotide-excision repair
M4S28_12510	COG4657	Part of a membrane complex involved in electron transport
M4S28_12515	COG2878	Part of a membrane complex involved in electron transport
M4S28_12520	COG4656	Part of a membrane complex involved in electron transport
M4S28_12525	COG4658	electron transport chain
M4S28_12530	COG4659	FMN binding
M4S28_12535	COG4660	Part of a membrane complex involved in electron transport
M4S28_12540	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
M4S28_12545	COG0346	lactoylglutathione lyase activity
M4S28_12565	COG2056	Na+-H+ antiporter family
M4S28_12575	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
M4S28_12595	COG1012	belongs to the aldehyde dehydrogenase family
M4S28_12595	COG1454	alcohol dehydrogenase
M4S28_12600	COG2095	MarC family integral membrane protein
M4S28_12605	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M4S28_12610	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
M4S28_12615	COG1757	Na H antiporter
M4S28_12630	COG3081	Nucleoid-associated protein
M4S28_12635	COG3082	Protein of unknown function (DUF1414)
M4S28_12640	COG3083	sulfuric ester hydrolase activity
M4S28_12655	COG1959	2 iron, 2 sulfur cluster binding
M4S28_12665	COG0123	including yeast histone deacetylase and acetoin utilization protein
M4S28_12680	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
M4S28_12685	COG0778	Nitroreductase
M4S28_12690	COG1902	pentaerythritol trinitrate reductase activity
M4S28_12690	COG0446	pyridine nucleotide-disulphide oxidoreductase
M4S28_12695	COG0616	signal peptide processing
M4S28_12700	COG0252	asparaginase activity
M4S28_12705	COG3139	Protein of unknown function (DUF1315)
M4S28_12715	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
M4S28_12720	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
M4S28_12735	COG2226	methyltransferase
M4S28_12755	COG1785	Belongs to the alkaline phosphatase family
M4S28_12775	COG2983	Belongs to the UPF0260 family
M4S28_12790	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
M4S28_12795	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
M4S28_12800	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
M4S28_12805	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
M4S28_12810	COG2832	Protein of unknown function (DUF454)
M4S28_12815	COG0745	RESPONSE REGULATOR receiver
M4S28_12820	COG0583	DNA-binding transcription factor activity
M4S28_12825	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
M4S28_12830	COG1286	toxin biosynthetic process
M4S28_12835	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
M4S28_12840	COG0285	dihydrofolate synthase activity
M4S28_12845	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
M4S28_12850	COG0101	tRNA pseudouridine synthase activity
M4S28_12860	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
M4S28_12865	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
M4S28_12870	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
M4S28_12880	COG0431	NADPH-dependent FMN reductase
M4S28_12890	COG3101	peptidyl-lysine hydroxylation
M4S28_12895	COG2860	membrane
M4S28_12900	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
M4S28_12915	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
M4S28_12925	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
M4S28_12930	COG0583	DNA-binding transcription factor activity
M4S28_12935	COG2951	lytic endotransglycosylase activity
M4S28_12940	COG3100	YcgL domain-containing protein
M4S28_12945	COG0850	regulation of cytokinetic process
M4S28_12950	COG2894	cell division
M4S28_12955	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
M4S28_12960	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
M4S28_12965	COG0318	PFAM AMP-dependent synthetase and ligase
M4S28_12970	COG0596	Alpha beta hydrolase
M4S28_12985	COG1214	PFAM Peptidase M22, glycoprotease
M4S28_12990	COG1199	ATP-dependent helicase activity
M4S28_13000	COG0788	formyltetrahydrofolate deformylase activity
M4S28_13005	COG3102	Protein conserved in bacteria
M4S28_13010	COG0018	arginyl-trna synthetase
M4S28_13030	COG1918	ferrous iron import across plasma membrane
M4S28_13045	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
M4S28_13050	COG1121	(ABC) transporter
M4S28_13055	COG1108	ABC-type Mn2 Zn2 transport systems permease components
M4S28_13065	COG0045	succinate-CoA ligase (ADP-forming) activity
M4S28_13070	COG0508	dehydrogenase complex catalyzes the overall conversion of
M4S28_13075	COG0567	Dehydrogenase, E1 component
M4S28_13085	COG1053	succinate dehydrogenase
M4S28_13090	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
M4S28_13100	COG0372	Belongs to the citrate synthase family
M4S28_13105	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
M4S28_13115	COG0033	Phosphoglucomutase
M4S28_13120	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
M4S28_13125	COG0596	Alpha beta hydrolase
M4S28_13150	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
M4S28_13155	COG1263	PTS System
M4S28_13155	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M4S28_13160	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
M4S28_13165	COG1940	carbohydrate kinase activity
M4S28_13165	COG1846	Transcriptional regulator
M4S28_13170	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
M4S28_13170	COG4651	solute:proton antiporter activity
M4S28_13175	COG0367	asparagine synthase
M4S28_13180	COG0250	Participates in transcription elongation, termination and antitermination
M4S28_13190	COG3104	oligopeptide transport
M4S28_13195	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
M4S28_13200	COG0563	adenylate kinase activity
M4S28_13205	COG0326	Molecular chaperone. Has ATPase activity
M4S28_13210	COG3710	Transcriptional regulator
M4S28_13225	COG0622	Phosphoesterase
M4S28_13250	COG1090	epimerase
M4S28_13255	COG0300	oxidoreductase activity
M4S28_13260	COG3118	belongs to the thioredoxin family
M4S28_13265	COG0330	HflC and HflK could
M4S28_13275	COG0789	Transcriptional regulator
M4S28_13290	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
M4S28_13295	COG3115	cell septum assembly
M4S28_13300	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
M4S28_13310	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
M4S28_13320	COG2190	(PTS) system
M4S28_13325	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
M4S28_13330	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
M4S28_13335	COG2837	iron assimilation
M4S28_13360	COG1393	Belongs to the ArsC family
M4S28_13365	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M4S28_13380	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
M4S28_13385	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M4S28_13390	COG2716	regulation of RNA biosynthetic process
M4S28_13395	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
M4S28_13410	COG4783	chaperone-mediated protein folding
M4S28_13415	COG1393	Belongs to the ArsC family
M4S28_13435	COG2233	PERMEase
M4S28_13440	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
M4S28_13445	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
M4S28_13450	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
M4S28_13455	COG0121	glutamine amidotransferase
M4S28_13460	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
M4S28_13475	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
M4S28_13480	COG0328	RNA-DNA hybrid ribonuclease activity
M4S28_13485	COG2226	methyltransferase
M4S28_13490	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M4S28_13495	COG0741	lytic transglycosylase activity
M4S28_13495	COG1388	LysM domain
M4S28_13505	COG3021	interspecies interaction between organisms
M4S28_13510	COG0347	Belongs to the P(II) protein family
M4S28_13520	COG0037	tRNA processing
M4S28_13525	COG0825	malonyl-CoA metabolic process
M4S28_13530	COG0587	DNA-directed DNA polymerase activity
M4S28_13535	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
M4S28_13545	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M4S28_13550	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
M4S28_13555	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M4S28_13560	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
M4S28_13570	COG0750	zinc metalloprotease
M4S28_13580	COG0575	Belongs to the CDS family
M4S28_13585	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
M4S28_13590	COG0233	cytoplasmic translational termination
M4S28_13595	COG0528	UMP kinase activity
M4S28_13600	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
M4S28_13605	COG0052	Belongs to the universal ribosomal protein uS2 family
M4S28_13610	COG0024	Methionine aminopeptidase
M4S28_13615	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
M4S28_13625	COG0564	pseudouridine synthase activity
M4S28_13630	COG3098	single-species biofilm formation
M4S28_13655	COG1671	Belongs to the UPF0178 family
M4S28_13675	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
M4S28_13685	COG0254	rRNA binding
M4S28_13690	COG1720	tRNA m6t6A37 methyltransferase activity
M4S28_13695	COG0442	prolyl-tRNA aminoacylation
M4S28_13720	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
M4S28_13740	COG0366	Alpha amylase catalytic
M4S28_13745	COG1263	PTS System
M4S28_13745	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M4S28_13750	COG1609	Transcriptional regulator
M4S28_13760	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
M4S28_13765	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
M4S28_13770	COG2011	ABC-type metal ion transport system permease component
M4S28_13775	COG1464	Belongs to the NlpA lipoprotein family
M4S28_13780	COG4580	involved in the transport of maltose and maltodextrins
M4S28_13785	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
M4S28_13800	COG2885	chlorophyll binding
M4S28_13815	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
M4S28_13815	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
M4S28_13830	COG1611	Belongs to the LOG family
M4S28_13835	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M4S28_13845	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
M4S28_13860	COG0583	DNA-binding transcription factor activity
M4S28_13865	COG0301	tRNA thio-modification
M4S28_13865	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
M4S28_13875	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
M4S28_13880	COG1722	exodeoxyribonuclease VII activity
M4S28_13885	COG0142	geranyltranstransferase activity
M4S28_13890	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
M4S28_13900	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
M4S28_13910	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
M4S28_13930	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M4S28_13930	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M4S28_13935	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
M4S28_13940	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
M4S28_13955	COG1073	alpha beta
M4S28_13960	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
M4S28_13965	COG2252	PERMEase
M4S28_13970	COG2195	Cleaves the N-terminal amino acid of tripeptides
M4S28_13990	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
M4S28_14005	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M4S28_14010	COG1609	Transcriptional regulator
M4S28_14015	COG2017	converts alpha-aldose to the beta-anomer
M4S28_14025	COG1085	galactose-1-phosphate uridylyltransferase
M4S28_14030	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
M4S28_14035	COG1609	Transcriptional regulator
M4S28_14040	COG3250	beta-galactosidase activity
M4S28_14045	COG2731	YhcH YjgK YiaL family protein
M4S28_14050	COG0531	amino acid
M4S28_14055	COG0531	amino acid
M4S28_14065	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
M4S28_14065	COG3408	Glycogen debranching enzyme
M4S28_14070	COG3250	beta-galactosidase activity
M4S28_14080	COG0395	ABC-type sugar transport system, permease component
M4S28_14085	COG1175	transmembrane transport
M4S28_14095	COG0534	Mate efflux family protein
M4S28_14100	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M4S28_14110	COG1609	Transcriptional regulator
M4S28_14115	COG0583	DNA-binding transcription factor activity
M4S28_14120	COG2059	Chromate
M4S28_14180	COG4964	Belongs to the GSP D family
M4S28_14210	COG1022	Amp-dependent synthetase and ligase
M4S28_14215	COG0583	DNA-binding transcription factor activity
M4S28_14225	COG0583	DNA-binding transcription factor activity
M4S28_14230	COG4628	conserved protein (DUF2132)
M4S28_14235	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
M4S28_14240	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
M4S28_14250	COG0560	Phosphoserine phosphatase
M4S28_14260	COG0813	purine-nucleoside phosphorylase activity
M4S28_14270	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
M4S28_14275	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
M4S28_14280	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
M4S28_14285	COG0084	hydrolase, TatD family'
M4S28_14310	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
M4S28_14325	COG3153	acetyltransferase
M4S28_14330	COG3154	lipid carrier protein
M4S28_14340	COG0826	peptidase U32
M4S28_14345	COG0826	peptidase U32
M4S28_14350	COG0534	Mate efflux family protein
M4S28_14365	COG1185	polyribonucleotide nucleotidyltransferase activity
M4S28_14370	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
M4S28_14375	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
M4S28_14380	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
M4S28_14385	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
M4S28_14390	COG0195	Participates in both transcription termination and antitermination
M4S28_14395	COG0779	Required for maturation of 30S ribosomal subunits
M4S28_14410	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
M4S28_14415	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M4S28_14420	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
M4S28_14425	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
M4S28_14430	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
M4S28_14435	COG1534	Rna-binding protein
M4S28_14440	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
M4S28_14445	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
M4S28_14450	COG2027	D-alanyl-D-alanine carboxypeptidase
M4S28_14455	COG2239	Acts as a magnesium transporter
M4S28_14460	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
M4S28_14465	COG0739	heme binding
M4S28_14480	COG0316	Belongs to the HesB IscA family
M4S28_14485	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
M4S28_14490	COG0628	permease
M4S28_14495	COG2813	Specifically methylates the guanine in position
M4S28_14505	COG0747	negative chemotaxis
M4S28_14515	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M4S28_14520	COG0444	Belongs to the ABC transporter superfamily
M4S28_14525	COG4608	Belongs to the ABC transporter superfamily
M4S28_14535	COG2971	BadF BadG BcrA BcrD
M4S28_14550	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M4S28_14555	COG3842	ATPase activity
M4S28_14565	COG1840	ABC-type Fe3 transport system, periplasmic component
M4S28_14570	COG0004	ammonium transporteR
M4S28_14585	COG1049	propionate catabolic process, 2-methylcitrate cycle
M4S28_14590	COG1752	Esterase of the alpha-beta hydrolase superfamily
M4S28_14595	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M4S28_14600	COG1643	Atp-dependent helicase
M4S28_14605	COG1489	DNA binding
M4S28_14625	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
M4S28_14630	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
M4S28_14635	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
M4S28_14640	COG0842	Transport permease protein
M4S28_14645	COG1131	(ABC) transporter
M4S28_14650	COG0659	secondary active sulfate transmembrane transporter activity
M4S28_14655	COG0288	reversible hydration of carbon dioxide
M4S28_14670	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M4S28_14675	COG0508	dehydrogenase complex catalyzes the overall conversion of
M4S28_14680	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
M4S28_14685	COG2186	Transcriptional regulator
M4S28_14695	COG0157	Belongs to the NadC ModD family
M4S28_14705	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
M4S28_14710	COG1459	type II secretion system
M4S28_14720	COG0237	dephospho-CoA kinase activity
M4S28_14725	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
M4S28_14735	COG0335	large ribosomal subunit rRNA binding
M4S28_14740	COG0336	Belongs to the RNA methyltransferase TrmD family
M4S28_14745	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
M4S28_14750	COG0228	four-way junction DNA binding
M4S28_14755	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
M4S28_14760	COG4137	Cytochrome C assembly protein
M4S28_14765	COG4536	flavin adenine dinucleotide binding
M4S28_14770	COG3385	transposase activity
M4S28_14775	COG1854	S-ribosylhomocysteine lyase activity
M4S28_14785	COG2918	glutathione biosynthetic process
M4S28_14790	COG0612	Peptidase, M16
M4S28_14795	COG1238	metal cluster binding
M4S28_14805	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
M4S28_14810	COG0511	ligase activity, forming carbon-carbon bonds
M4S28_14810	COG5016	pyruvate
M4S28_14815	COG3630	sodium ion export across plasma membrane
M4S28_14875	COG0527	aspartate kinase activity
M4S28_14885	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
M4S28_14920	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
M4S28_14935	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
M4S28_14965	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
M4S28_14975	COG1546	Belongs to the CinA family
M4S28_14980	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
M4S28_14985	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
M4S28_14995	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
M4S28_15000	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
M4S28_15005	COG0585	pseudouridine synthase activity
M4S28_15015	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
M4S28_15020	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
M4S28_15025	COG0148	phosphopyruvate hydratase activity
M4S28_15030	COG0504	CTP synthase activity
M4S28_15035	COG3956	TIGRFAM MazG family protein
M4S28_15040	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
M4S28_15045	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
M4S28_15050	COG4999	Histidine kinase
M4S28_15050	COG3437	response regulator, receiver
M4S28_15050	COG2205	protein histidine kinase activity
M4S28_15050	COG3850	Histidine kinase
M4S28_15055	COG0736	holo-[acyl-carrier-protein] synthase activity
M4S28_15060	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
M4S28_15065	COG1381	Involved in DNA repair and RecF pathway recombination
M4S28_15070	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
M4S28_15075	COG0571	ribonuclease III activity
M4S28_15085	COG0481	GTPase activity
M4S28_15105	COG1595	DNA-templated transcription, initiation
M4S28_15110	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
M4S28_15115	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
M4S28_15120	COG0354	folic acid binding
M4S28_15135	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M4S28_15140	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M4S28_15145	COG3079	Belongs to the UPF0149 family
M4S28_15150	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
M4S28_15160	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
M4S28_15165	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
M4S28_15170	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
M4S28_15190	COG1279	arginine transmembrane transporter activity
M4S28_15195	COG0668	transmembrane transport
M4S28_15200	COG0191	fructose-bisphosphate aldolase activity
M4S28_15215	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
M4S28_15220	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
M4S28_15230	COG3091	SprT-like family
M4S28_15235	COG2356	endonuclease I
M4S28_15240	COG1385	rRNA (uridine-N3-)-methyltransferase activity
M4S28_15245	COG0189	ligase activity
M4S28_15250	COG1678	Uncharacterized ACR, COG1678
M4S28_15255	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
M4S28_15275	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
M4S28_15280	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
M4S28_15285	COG0762	integral membrane protein
M4S28_15410	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
M4S28_15415	COG0635	Involved in the biosynthesis of porphyrin-containing compound
M4S28_15420	COG2066	Belongs to the glutaminase family
M4S28_15435	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
M4S28_15440	COG0741	lytic transglycosylase activity
M4S28_15480	COG0840	transmembrane signaling receptor activity
M4S28_15590	COG0795	lipopolysaccharide-transporting ATPase activity
M4S28_15595	COG0795	lipopolysaccharide-transporting ATPase activity
M4S28_15600	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
M4S28_15605	COG2927	DNA polymerase III (CHI subunit)
M4S28_15610	COG0525	valine-tRNA ligase activity
M4S28_15615	COG0501	Belongs to the peptidase M48B family
M4S28_15620	COG4269	membrane
M4S28_15630	COG0456	acetyltransferase
M4S28_15660	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
M4S28_15665	COG0251	oxidation-reduction process
M4S28_15670	COG0204	Acyl-transferase
M4S28_15675	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
M4S28_15680	COG5007	Belongs to the BolA IbaG family
M4S28_15690	COG2854	intermembrane phospholipid transfer
M4S28_15695	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
M4S28_15700	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
M4S28_15705	COG1127	ABC transporter
M4S28_15715	COG0517	IMP dehydrogenase activity
M4S28_15715	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
M4S28_15720	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
M4S28_15730	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
M4S28_15735	COG1137	ATPase activity
M4S28_15745	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
M4S28_15750	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
M4S28_15755	COG1660	Displays ATPase and GTPase activities
M4S28_15760	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
M4S28_15765	COG2239	Acts as a magnesium transporter
M4S28_15770	COG0312	modulator of DNA gyrase
M4S28_15775	COG3028	Belongs to the UPF0307 family
M4S28_15780	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
M4S28_15785	COG1178	ABC-type Fe3 transport system permease component
M4S28_15790	COG4143	(ABC) transporter
M4S28_15795	COG0163	prenyltransferase activity
M4S28_15800	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
M4S28_15805	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
M4S28_15810	COG2105	PFAM AIG2 family protein
M4S28_15815	COG2911	Protein conserved in bacteria
M4S28_15820	COG0729	surface antigen
M4S28_15825	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
M4S28_15835	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
M4S28_15870	COG0529	Catalyzes the synthesis of activated sulfate
M4S28_15875	COG0471	metal ion transport
M4S28_15875	COG3273	potassium ion transport
M4S28_15880	COG2895	sulfate adenylyltransferase (ATP) activity
M4S28_15885	COG0175	sulfate reduction
M4S28_15935	COG2153	protein acetylation
M4S28_15945	COG3061	Opacity-associated protein A
M4S28_15945	COG3266	domain, Protein
M4S28_15950	COG0545	Peptidyl-prolyl cis-trans isomerase
M4S28_15960	COG0203	ribosomal protein L17
M4S28_15965	COG0202	RNA polymerase activity
M4S28_15970	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
M4S28_15975	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
M4S28_15980	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
M4S28_15985	COG0257	Belongs to the bacterial ribosomal protein bL36 family
M4S28_15990	COG0201	protein transport
M4S28_15995	COG0200	Binds to the 23S rRNA
M4S28_16000	COG1841	ribosomal large subunit assembly
M4S28_16005	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
M4S28_16015	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
M4S28_16020	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
M4S28_16025	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
M4S28_16030	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
M4S28_16035	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
M4S28_16040	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
M4S28_16045	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
M4S28_16055	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
M4S28_16060	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
M4S28_16070	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
M4S28_16075	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
M4S28_16080	COG0089	rRNA binding
M4S28_16085	COG0088	Forms part of the polypeptide exit tunnel
M4S28_16090	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
M4S28_16105	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
M4S28_16110	COG0049	tRNA binding
M4S28_16125	COG2923	Belongs to the DsrF TusC family
M4S28_16130	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
M4S28_16135	COG2964	Protein conserved in bacteria
M4S28_16140	COG0545	Peptidyl-prolyl cis-trans isomerase
M4S28_16150	COG2900	Belongs to the SlyX family
M4S28_16155	COG1446	asparaginase
M4S28_16160	COG1047	Peptidyl-prolyl cis-trans
M4S28_16175	COG2249	NAD(P)H dehydrogenase (quinone) activity
M4S28_16180	COG0488	(ABC) transporter
M4S28_16190	COG0429	hydrolase of the alpha beta-hydrolase fold
M4S28_16195	COG3089	Belongs to the UPF0270 family
M4S28_16200	COG3954	Phosphoribulokinase
M4S28_16205	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M4S28_16215	COG1012	belongs to the aldehyde dehydrogenase family
M4S28_16225	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
M4S28_16230	COG0512	Glutamine amidotransferase of anthranilate synthase
M4S28_16240	COG0180	Tryptophanyl-tRNA synthetase
M4S28_16245	COG0546	phosphoglycolate phosphatase activity
M4S28_16250	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
M4S28_16255	COG0338	D12 class N6 adenine-specific DNA methyltransferase
M4S28_16265	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
M4S28_16300	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
M4S28_16315	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
M4S28_16315	COG0678	peroxiredoxin activity
M4S28_16320	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M4S28_16325	COG0251	oxidation-reduction process
M4S28_16335	COG0165	Argininosuccinate lyase
M4S28_16335	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
M4S28_16350	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
M4S28_16355	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M4S28_16360	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
M4S28_16370	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
M4S28_16375	COG0460	homoserine dehydrogenase
M4S28_16375	COG0527	aspartate kinase activity
M4S28_16380	COG0626	cystathionine gamma-synthase activity
M4S28_16385	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
M4S28_16390	COG0281	malic enzyme
M4S28_16395	COG0254	rRNA binding
M4S28_16400	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
M4S28_16405	COG1609	Transcriptional regulator
M4S28_16415	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
M4S28_16420	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
M4S28_16425	COG1575	Belongs to the MenA family. Type 1 subfamily
M4S28_16430	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
M4S28_16470	COG2814	Major facilitator Superfamily
M4S28_16480	COG2207	Transcriptional regulator
M4S28_16480	COG3708	Transcriptional regulator
M4S28_16535	COG0840	transmembrane signaling receptor activity
M4S28_16540	COG4533	DNA binding
M4S28_16545	COG0189	ligase activity
M4S28_16550	COG4067	protein conserved in archaea
M4S28_16550	COG0189	ligase activity
M4S28_16555	COG3385	transposase activity
M4S28_16580	COG1175	transmembrane transport
M4S28_16585	COG0395	ABC-type sugar transport system, permease component
M4S28_16590	COG3842	ATPase activity
M4S28_16595	COG0584	glycerophosphoryl diester phosphodiesterase
M4S28_16615	COG0673	inositol 2-dehydrogenase activity
M4S28_16625	COG2999	glutathione oxidoreductase activity
M4S28_16630	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
M4S28_16645	COG0534	Mate efflux family protein
M4S28_16650	COG2964	Protein conserved in bacteria
M4S28_16665	COG0446	pyridine nucleotide-disulphide oxidoreductase
M4S28_16675	COG2194	sulfuric ester hydrolase activity
M4S28_16730	COG1901	pseudouridine methyltransferase
M4S28_16770	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M4S28_16800	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
M4S28_16810	COG0583	DNA-binding transcription factor activity
M4S28_16815	COG2910	NAD(P)H-binding
M4S28_16825	COG1028	Short-chain dehydrogenase reductase Sdr
M4S28_16830	COG1733	regulation of RNA biosynthetic process
M4S28_16835	COG0583	DNA-binding transcription factor activity
M4S28_16840	COG4221	oxidoreductase activity
M4S28_16850	COG3047	cAMP biosynthetic process
M4S28_16855	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
M4S28_16860	COG1288	antiporter activity
M4S28_16885	COG3639	organic phosphonate transmembrane transporter activity
M4S28_16890	COG3639	organic phosphonate transmembrane transporter activity
M4S28_16895	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
M4S28_16920	COG4948	Mandelate Racemase Muconate Lactonizing
M4S28_16930	COG0583	DNA-binding transcription factor activity
M4S28_16955	COG0583	DNA-binding transcription factor activity
M4S28_16980	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M4S28_16985	COG3385	transposase activity
M4S28_17000	COG2814	Major facilitator Superfamily
M4S28_17005	COG0814	amino acid
M4S28_17010	COG2211	Major facilitator Superfamily
M4S28_17015	COG1397	ADP-ribosylglycohydrolase
M4S28_17020	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M4S28_17025	COG2223	nitrite transmembrane transporter activity
M4S28_17030	COG2188	Transcriptional regulator
M4S28_17035	COG1846	Transcriptional regulator
M4S28_17040	COG1764	response to oxidative stress
M4S28_17050	COG1012	belongs to the aldehyde dehydrogenase family
M4S28_17060	COG0840	transmembrane signaling receptor activity
M4S28_17075	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M4S28_17080	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M4S28_17090	COG2207	Transcriptional regulator
M4S28_17095	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M4S28_17095	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
M4S28_17095	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M4S28_17110	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M4S28_17115	COG3842	ATPase activity
M4S28_17120	COG0546	phosphoglycolate phosphatase activity
M4S28_17145	COG0583	DNA-binding transcription factor activity
M4S28_17150	COG4166	transmembrane transport
M4S28_17165	COG3012	SEC-C Motif Domain Protein
M4S28_17175	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
M4S28_17180	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
M4S28_17200	COG1012	belongs to the aldehyde dehydrogenase family
M4S28_17205	COG3284	Transcriptional regulator
M4S28_17210	COG0840	transmembrane signaling receptor activity
M4S28_17225	COG3655	Transcriptional regulator
M4S28_17260	COG2161	toxin-antitoxin pair type II binding
M4S28_17265	COG4115	mRNA cleavage
M4S28_17275	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
M4S28_17280	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M4S28_17285	COG1418	mRNA catabolic process
M4S28_17310	COG1529	Aldehyde oxidase and xanthine dehydrogenase
M4S28_17320	COG0402	S-adenosylhomocysteine deaminase activity
M4S28_17330	COG3423	Transcriptional regulator
M4S28_17335	COG2801	Transposase and inactivated derivatives
M4S28_17340	COG2842	Transposition protein
M4S28_17440	COG0640	Transcriptional regulator
M4S28_17455	COG4373	Mu-like prophage FluMu protein gp28
M4S28_17465	COG4383	Mu-like prophage protein gp29
M4S28_17480	COG4397	Mu-like prophage major head subunit gpT
M4S28_17500	COG4387	Mu-like prophage protein GP36
M4S28_17520	COG4386	tail sheath protein
M4S28_17550	COG4384	Bacteriophage Mu Gp45 protein
M4S28_17565	COG3778	Protein conserved in bacteria
M4S28_17585	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
M4S28_17590	COG0789	Transcriptional regulator
M4S28_17605	COG2814	Major facilitator Superfamily
M4S28_17615	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
M4S28_17630	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
M4S28_17635	COG4266	Belongs to the allantoicase family
M4S28_17655	COG2252	PERMEase
M4S28_17680	COG0402	S-adenosylhomocysteine deaminase activity
M4S28_17695	COG2084	Dehydrogenase
M4S28_17700	COG3622	Belongs to the hyi family
M4S28_17705	COG3960	tartronate-semialdehyde synthase activity
M4S28_17710	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
M4S28_17720	COG2259	Doxx family
M4S28_17725	COG1846	Transcriptional regulator
M4S28_17805	COG4964	Belongs to the GSP D family
M4S28_17895	COG1067	ATP-dependent peptidase activity
M4S28_17905	COG4172	Belongs to the ABC transporter superfamily
M4S28_17920	COG2378	regulation of single-species biofilm formation
M4S28_17925	COG1609	Transcriptional regulator
M4S28_17935	COG2017	converts alpha-aldose to the beta-anomer
M4S28_17940	COG3459	Glycosyltransferase 36 associated
M4S28_17945	COG3842	ATPase activity
M4S28_17950	COG2723	6-phospho-beta-galactosidase activity
M4S28_17955	COG0395	ABC-type sugar transport system, permease component
M4S28_17975	COG0840	transmembrane signaling receptor activity
M4S28_17990	COG1505	serine-type exopeptidase activity
M4S28_17995	COG0583	DNA-binding transcription factor activity
M4S28_18000	COG1620	l-lactate permease
M4S28_18005	COG1304	FMN binding
M4S28_18025	COG0747	negative chemotaxis
M4S28_18030	COG4608	Belongs to the ABC transporter superfamily
M4S28_18040	COG0534	Mate efflux family protein
M4S28_18045	COG2207	Transcriptional regulator
M4S28_18045	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M4S28_18050	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M4S28_18065	COG1054	Belongs to the UPF0176 family
M4S28_18090	COG2271	Major facilitator Superfamily
M4S28_18095	COG3851	Histidine kinase
M4S28_18100	COG2197	response regulator
M4S28_18125	COG1741	Belongs to the pirin family
M4S28_18130	COG3123	guanosine phosphorylase activity
M4S28_18145	COG0596	Alpha beta hydrolase
M4S28_18190	COG3788	relative of glutathione S-transferase, MAPEG superfamily
M4S28_18195	COG0700	Nucleoside recognition
M4S28_18200	COG3366	ferrous iron transmembrane transporter activity
M4S28_18210	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
M4S28_18225	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
M4S28_18245	COG0363	glucosamine-6-phosphate deaminase activity
M4S28_18250	COG3722	fumarate hydratase activity
M4S28_18255	COG0246	Mannitol dehydrogenase
M4S28_18260	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
M4S28_18260	COG2213	PTS system mannitol-specific
M4S28_18285	COG0446	pyridine nucleotide-disulphide oxidoreductase
M4S28_18290	COG0786	glutamate:sodium symporter activity
M4S28_18305	COG1942	4-Oxalocrotonate Tautomerase
M4S28_18315	COG1595	DNA-templated transcription, initiation
M4S28_18320	COG3806	Anti-sigma factor
M4S28_18330	COG0415	Belongs to the DNA photolyase family
M4S28_18355	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
M4S28_18380	COG4221	oxidoreductase activity
M4S28_18385	COG0724	RNA recognition motif
M4S28_18395	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
M4S28_18410	COG1263	PTS System
M4S28_18410	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M4S28_18410	COG2190	(PTS) system
M4S28_18440	COG2205	protein histidine kinase activity
M4S28_18505	COG1028	Short-chain dehydrogenase reductase Sdr
M4S28_18510	COG2814	Major facilitator Superfamily
M4S28_18515	COG1902	pentaerythritol trinitrate reductase activity
M4S28_18525	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
M4S28_18530	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
M4S28_18540	COG0612	Peptidase, M16
M4S28_18545	COG3279	Response regulator of the LytR AlgR family
M4S28_18550	COG3275	phosphorelay sensor kinase activity
M4S28_18565	COG4591	ABC-type transport system involved in lipoprotein release permease component
M4S28_18580	COG0583	DNA-binding transcription factor activity
M4S28_18595	COG2084	Dehydrogenase
M4S28_18610	COG0217	transcriptional regulatory protein
M4S28_18625	COG3186	Phenylalanine-4-hydroxylase
M4S28_18630	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M4S28_18640	COG0625	glutathione transferase activity
M4S28_18650	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
M4S28_18670	COG3842	ATPase activity
M4S28_18710	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
M4S28_18710	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
M4S28_18720	COG0444	Belongs to the ABC transporter superfamily
M4S28_18725	COG4608	Belongs to the ABC transporter superfamily
M4S28_18750	COG1444	tRNA N-acetyltransferase activity
M4S28_18790	COG0259	pyridoxamine-phosphate oxidase activity
M4S28_18825	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M4S28_18855	COG4399	Belongs to the UPF0754 family
M4S28_18860	COG1132	(ABC) transporter
M4S28_18895	COG2194	sulfuric ester hydrolase activity
M4S28_18925	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
M4S28_18935	COG4145	pantothenate transmembrane transporter activity
M4S28_18940	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M4S28_18945	COG0800	Aldolase
M4S28_18960	COG2204	response regulator
M4S28_18975	COG0579	oxidoreductase
M4S28_18995	COG2205	protein histidine kinase activity
M4S28_19000	COG0745	RESPONSE REGULATOR receiver
M4S28_19015	COG1522	sequence-specific DNA binding
M4S28_19025	COG1473	amidohydrolase
M4S28_19030	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
M4S28_19040	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
M4S28_19050	COG1309	transcriptional regulator
M4S28_19055	COG1012	belongs to the aldehyde dehydrogenase family
M4S28_19075	COG4175	Glycine betaine
M4S28_19075	COG0517	IMP dehydrogenase activity
M4S28_19080	COG1846	Transcriptional regulator
M4S28_19110	COG0641	radical SAM
M4S28_19115	COG1309	transcriptional regulator
M4S28_19150	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
M4S28_19155	COG0800	Aldolase
M4S28_19160	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M4S28_19165	COG1263	PTS System
M4S28_19165	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M4S28_19180	COG2188	Transcriptional regulator
M4S28_19190	COG0110	maltose O-acetyltransferase activity
M4S28_19195	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
M4S28_19205	COG2918	glutathione biosynthetic process
M4S28_19210	COG1132	(ABC) transporter
M4S28_19215	COG1132	(ABC) transporter
M4S28_19230	COG0604	alcohol dehydrogenase
M4S28_19230	COG1028	Short-chain dehydrogenase reductase Sdr
M4S28_19230	COG3321	synthase
M4S28_19275	COG2015	COG2015, Alkyl sulfatase and related hydrolases
M4S28_19290	COG0346	lactoylglutathione lyase activity
M4S28_19315	COG2723	6-phospho-beta-galactosidase activity
M4S28_19320	COG1609	Transcriptional regulator
M4S28_19325	COG0110	maltose O-acetyltransferase activity
M4S28_19335	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
M4S28_19345	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M4S28_19365	COG0641	radical SAM
M4S28_19370	COG0583	DNA-binding transcription factor activity
M4S28_19375	COG3119	arylsulfatase activity
M4S28_19395	COG0549	Belongs to the carbamate kinase family
M4S28_19400	COG0531	amino acid
M4S28_19405	COG2957	Belongs to the agmatine deiminase family
M4S28_19410	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
M4S28_19440	COG0583	DNA-binding transcription factor activity
M4S28_19445	COG1028	Short-chain dehydrogenase reductase Sdr
M4S28_19450	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
M4S28_19455	COG1349	DNA-binding transcription factor activity
M4S28_19460	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
M4S28_19465	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
M4S28_19490	COG2994	toxin metabolic process
M4S28_19495	COG1073	alpha beta
M4S28_19495	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
M4S28_19495	COG3064	Membrane
M4S28_19505	COG0583	DNA-binding transcription factor activity
M4S28_19510	COG0798	PFAM Bile acid sodium symporter
M4S28_19530	COG0561	phosphatase activity
M4S28_19540	COG3214	Protein conserved in bacteria
M4S28_19545	COG0583	DNA-binding transcription factor activity
M4S28_19605	COG0561	phosphatase activity
M4S28_19610	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
M4S28_19615	COG3623	hexulose-6-phosphate isomerase
M4S28_19625	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M4S28_19630	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
M4S28_19650	COG3623	hexulose-6-phosphate isomerase
M4S28_19655	COG1414	Transcriptional regulator
M4S28_19660	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
M4S28_19675	COG0561	phosphatase activity
M4S28_19685	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
M4S28_19690	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
M4S28_19695	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
M4S28_19705	COG1929	Belongs to the glycerate kinase type-1 family
M4S28_19710	COG0753	catalase activity
M4S28_19715	COG4667	esterase of the alpha-beta hydrolase superfamily
M4S28_19720	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
M4S28_19730	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M4S28_19735	COG0204	Acyl-transferase
M4S28_19740	COG2384	SAM-dependent methyltransferase
M4S28_19755	COG4580	involved in the transport of maltose and maltodextrins
M4S28_19795	COG3258	Cytochrome c
M4S28_19825	COG4566	intracellular signal transduction
M4S28_19835	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
M4S28_19840	COG1162	GTPase activity
M4S28_19850	COG1999	signal sequence binding
M4S28_19865	COG2909	trisaccharide binding
M4S28_19870	COG0058	SHG alpha-glucan phosphorylase activity
M4S28_19875	COG1640	4-alpha-glucanotransferase
M4S28_19880	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
M4S28_19890	COG3385	transposase activity
M4S28_19900	COG1122	ATPase activity
M4S28_19905	COG4720	Psort location CytoplasmicMembrane, score
M4S28_19910	COG1566	PFAM secretion protein HlyD family protein
M4S28_19940	COG0813	purine-nucleoside phosphorylase activity
M4S28_19945	COG1376	ErfK ybiS ycfS ynhG family protein
M4S28_19945	COG1388	LysM domain
M4S28_19955	COG0513	Belongs to the DEAD box helicase family
M4S28_19960	COG3240	lipase activity
M4S28_19965	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
M4S28_19975	COG0840	transmembrane signaling receptor activity
M4S28_19985	COG0573	inorganic phosphate transmembrane transporter activity
M4S28_19990	COG0581	inorganic phosphate transmembrane transporter activity
M4S28_19995	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
M4S28_20020	COG2304	oxidoreductase activity
M4S28_20025	COG2304	oxidoreductase activity
M4S28_20040	COG0714	Associated with various cellular activities
M4S28_20045	COG0840	transmembrane signaling receptor activity
M4S28_20055	COG3842	ATPase activity
M4S28_20065	COG1175	transmembrane transport
M4S28_20070	COG3833	ABC-type maltose transport systems, permease component
M4S28_20110	COG0583	DNA-binding transcription factor activity
M4S28_20125	COG2356	endonuclease I
M4S28_20135	COG0577	efflux transmembrane transporter activity
M4S28_20140	COG1136	(ABC) transporter
M4S28_20165	COG0737	Belongs to the 5'-nucleotidase family
M4S28_20170	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
M4S28_20180	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M4S28_20195	COG1032	radical SAM domain protein
M4S28_20210	COG3706	GGDEF domain
M4S28_20230	COG1028	Short-chain dehydrogenase reductase Sdr
M4S28_20265	COG4934	collagen metabolic process
M4S28_20295	COG1012	belongs to the aldehyde dehydrogenase family
M4S28_20300	COG1414	Transcriptional regulator
M4S28_20310	COG0730	response to heat
M4S28_20340	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M4S28_20345	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
M4S28_20350	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
M4S28_20355	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
M4S28_20355	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
M4S28_20370	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M4S28_20385	COG0418	dihydroorotase activity
M4S28_20395	COG0633	Ferredoxin
M4S28_20395	COG3217	Mosc domain protein beta barrel domain protein
M4S28_20400	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
M4S28_20445	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
M4S28_20450	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M4S28_20460	COG0848	biopolymer transport protein
M4S28_20465	COG0811	peptide transport
M4S28_20470	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
M4S28_20480	COG3721	Heme iron utilization protein
M4S28_20485	COG0748	coenzyme F420 binding
M4S28_20490	COG2096	Adenosyltransferase
M4S28_20495	COG0784	Response regulator, receiver
M4S28_20495	COG0835	chemotaxis
M4S28_20500	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M4S28_20505	COG0366	Alpha amylase catalytic
M4S28_20515	COG3314	Sporulation integral membrane protein YlbJ
M4S28_20540	COG0739	heme binding
M4S28_20545	COG5001	Diguanylate cyclase
M4S28_20550	COG0583	DNA-binding transcription factor activity
M4S28_20555	COG2814	Major facilitator Superfamily
M4S28_20570	COG0697	spore germination
M4S28_20585	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
M4S28_20585	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M4S28_20590	COG3118	belongs to the thioredoxin family
M4S28_20595	COG4232	protein-disulfide reductase activity
M4S28_20610	COG0668	transmembrane transport
M4S28_20655	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M4S28_20660	COG1538	Outer membrane efflux protein
M4S28_20680	COG4989	oxidoreductase activity
M4S28_20685	COG0513	Belongs to the DEAD box helicase family
M4S28_20700	COG2176	DNA-directed DNA polymerase activity
M4S28_20710	COG0513	Belongs to the DEAD box helicase family
M4S28_20715	COG0778	Nitroreductase
M4S28_20730	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
M4S28_20735	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
M4S28_20740	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M4S28_20745	COG0667	Aldo Keto reductase
M4S28_20755	COG2195	Cleaves the N-terminal amino acid of tripeptides
M4S28_20790	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
M4S28_20805	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
M4S28_20810	COG0513	Belongs to the DEAD box helicase family
M4S28_20815	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
M4S28_20830	COG1396	sequence-specific DNA binding
M4S28_20835	COG3135	benzoate transporter
M4S28_20870	COG0019	diaminopimelate decarboxylase activity
M4S28_20875	COG4264	IucA IucC family
M4S28_20900	COG4772	TonB-dependent receptor
M4S28_20905	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
M4S28_20910	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M4S28_20915	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M4S28_20920	COG1120	ATPase activity
M4S28_20935	COG0366	Alpha amylase catalytic
M4S28_20945	COG0583	DNA-binding transcription factor activity
M4S28_20950	COG0534	Mate efflux family protein
M4S28_20980	COG0516	GMP reductase activity
M4S28_20985	COG0582	viral genome integration into host DNA
M4S28_21085	COG0653	protein targeting
M4S28_21090	COG4695	Portal protein
M4S28_21275	COG0697	spore germination
M4S28_21280	COG0351	phosphomethylpyrimidine kinase
M4S28_21285	COG1116	anion transmembrane transporter activity
M4S28_21290	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M4S28_21295	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M4S28_21300	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
M4S28_21305	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
M4S28_21315	COG0352	thiamine-phosphate diphosphorylase activity
M4S28_21325	COG0583	DNA-binding transcription factor activity
M4S28_21340	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
M4S28_21365	COG3706	GGDEF domain
M4S28_21375	COG1566	PFAM secretion protein HlyD family protein
M4S28_21385	COG0628	permease
M4S28_21415	COG4607	ABC-type enterochelin transport system periplasmic component
M4S28_21420	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M4S28_21425	COG4605	iron ion homeostasis
M4S28_21430	COG4604	ABC transporter, ATP-binding protein
M4S28_21435	COG3437	response regulator, receiver
M4S28_21445	COG0583	DNA-binding transcription factor activity
M4S28_21450	COG2814	Major facilitator Superfamily
M4S28_21470	COG1522	sequence-specific DNA binding
M4S28_21475	COG0840	transmembrane signaling receptor activity
M4S28_21480	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
M4S28_21500	COG4584	PFAM Integrase catalytic
M4S28_21505	COG1484	DNA-dependent DNA replication
M4S28_21530	COG4964	Belongs to the GSP D family
M4S28_21585	COG5001	Diguanylate cyclase
M4S28_21585	COG2203	Gaf domain
M4S28_21585	COG3706	GGDEF domain
M4S28_21585	COG4251	negative regulation of phosphorylation
M4S28_21590	COG2897	thiosulfate sulfurtransferase activity
M4S28_21620	COG0302	gtp cyclohydrolase
M4S28_21630	COG4681	YaeQ
M4S28_21670	COG4386	tail sheath protein
M4S28_21710	COG4695	Portal protein
M4S28_21770	COG4228	DNA circulation
M4S28_21865	COG1278	Cold shock
M4S28_21870	COG2133	pyrroloquinoline quinone binding
M4S28_21880	COG1120	ATPase activity
M4S28_21910	COG1024	Enoyl-CoA hydratase
M4S28_21930	COG2985	domain, Protein
M4S28_21940	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M4S28_21945	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M4S28_21960	COG3710	Transcriptional regulator
M4S28_21970	COG1902	pentaerythritol trinitrate reductase activity
M4S28_21985	COG1132	(ABC) transporter
M4S28_21990	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M4S28_22015	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M4S28_22050	COG2824	Alkylphosphonate utilization operon protein PhnA
M4S28_22090	COG0765	amino acid transport
M4S28_22095	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M4S28_22100	COG0765	amino acid transport
M4S28_22105	COG1126	abc transporter atp-binding protein
M4S28_22110	COG1979	alcohol dehydrogenase
M4S28_22115	COG2207	Transcriptional regulator
M4S28_22170	COG3059	membrane
M4S28_22180	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M4S28_22195	COG3706	GGDEF domain
M4S28_22210	COG1686	Belongs to the peptidase S11 family
M4S28_22220	COG0583	DNA-binding transcription factor activity
M4S28_22230	COG0564	pseudouridine synthase activity
M4S28_22240	COG2130	NADP-dependent
M4S28_22245	COG1309	transcriptional regulator
M4S28_22250	COG0545	Peptidyl-prolyl cis-trans isomerase
M4S28_22270	COG3604	Transcriptional regulator
M4S28_22275	COG1017	nitric oxide dioxygenase activity
M4S28_22275	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M4S28_22285	COG0038	chloride channel
M4S28_22290	COG0523	cobalamin synthesis protein
M4S28_22295	COG0513	Belongs to the DEAD box helicase family
M4S28_22300	COG1280	lysine exporter protein (LysE YggA)
M4S28_22325	COG0745	RESPONSE REGULATOR receiver
M4S28_22370	COG3005	denitrification pathway
M4S28_22380	COG0243	molybdopterin cofactor binding
M4S28_22390	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
M4S28_22390	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
M4S28_22395	COG3850	Histidine kinase
M4S28_22400	COG2197	response regulator
M4S28_22405	COG3069	C4-dicarboxylate transmembrane transporter activity
M4S28_22420	COG2267	carboxylic ester hydrolase activity
M4S28_22430	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M4S28_22435	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M4S28_22455	COG2188	Transcriptional regulator
M4S28_22460	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M4S28_22460	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M4S28_22460	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
M4S28_22465	COG0383	alpha-mannosidase activity
M4S28_22470	COG1929	Belongs to the glycerate kinase type-1 family
M4S28_22500	COG3706	GGDEF domain
M4S28_22505	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
M4S28_22510	COG0739	heme binding
M4S28_22550	COG3501	Rhs element vgr protein
M4S28_22575	COG0515	serine threonine protein kinase
M4S28_22575	COG2815	serine threonine protein kinase
M4S28_22610	COG1522	sequence-specific DNA binding
M4S28_22735	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
M4S28_22740	COG0494	nUDIX hydrolase
M4S28_22750	COG2425	protein containing a von Willebrand factor type A (vWA) domain
M4S28_22775	COG0840	transmembrane signaling receptor activity
M4S28_22825	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M4S28_22835	COG2116	formate transmembrane transporter activity
M4S28_22840	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
M4S28_22840	COG1648	precorrin-2 dehydrogenase activity
M4S28_22855	COG0745	RESPONSE REGULATOR receiver
M4S28_22860	COG2205	protein histidine kinase activity
M4S28_22865	COG1301	dicarboxylic acid transport
M4S28_22870	COG4774	siderophore transport
M4S28_22880	COG0811	peptide transport
M4S28_22885	COG0811	peptide transport
M4S28_22890	COG0848	biopolymer transport protein
M4S28_22935	COG0803	Belongs to the bacterial solute-binding protein 9 family
M4S28_22940	COG1121	(ABC) transporter
M4S28_22945	COG1108	ABC-type Mn2 Zn2 transport systems permease components
M4S28_22945	COG1321	iron dependent repressor
M4S28_22970	COG0534	Mate efflux family protein
M4S28_23000	COG0318	PFAM AMP-dependent synthetase and ligase
M4S28_23010	COG3118	belongs to the thioredoxin family
M4S28_23015	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
M4S28_23045	COG1328	CTP reductase activity
M4S28_23050	COG0602	queuosine metabolic process
M4S28_23055	COG0534	Mate efflux family protein
M4S28_23070	COG0189	ligase activity
M4S28_23070	COG4067	protein conserved in archaea
M4S28_23075	COG0488	(ABC) transporter
M4S28_23095	COG0725	ABC transporter, periplasmic molybdate-binding protein
M4S28_23100	COG4149	molybdate abc transporter
M4S28_23105	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
M4S28_23115	COG4251	negative regulation of phosphorylation
M4S28_23115	COG5001	Diguanylate cyclase
M4S28_23115	COG2203	Gaf domain
M4S28_23115	COG3706	GGDEF domain
M4S28_23125	COG3706	GGDEF domain
M4S28_23140	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
M4S28_23145	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
M4S28_23170	COG3140	Belongs to the UPF0181 family
M4S28_23175	COG3706	GGDEF domain
M4S28_23210	COG0023	Translation Initiation Factor
M4S28_23225	COG1181	Belongs to the D-alanine--D-alanine ligase family
M4S28_23230	COG3266	domain, Protein
M4S28_23235	COG0045	succinate-CoA ligase (ADP-forming) activity
M4S28_23235	COG1042	CoA-binding domain protein
M4S28_23235	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M4S28_23240	COG0583	DNA-binding transcription factor activity
M4S28_23245	COG4771	TonB-dependent receptor
M4S28_23245	COG1629	transport
M4S28_23275	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
M4S28_23280	COG1984	allophanate hydrolase subunit 2
M4S28_23290	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
M4S28_23295	COG4181	ATPase activity
M4S28_23305	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
M4S28_23310	COG1716	ATPase activity
M4S28_23310	COG5001	Diguanylate cyclase
M4S28_23320	COG0768	penicillin binding
M4S28_23350	COG4533	DNA binding
M4S28_23360	COG2050	protein possibly involved in aromatic compounds catabolism
M4S28_23365	COG0501	Belongs to the peptidase M48B family
M4S28_23375	COG2067	long-chain fatty acid transport protein
M4S28_23380	COG2267	carboxylic ester hydrolase activity
M4S28_23390	COG0583	DNA-binding transcription factor activity
M4S28_23410	COG0513	Belongs to the DEAD box helicase family
M4S28_23425	COG0861	Integral membrane protein TerC family
M4S28_23430	COG0737	Belongs to the 5'-nucleotidase family
M4S28_23435	COG3593	DNA synthesis involved in DNA repair
M4S28_23445	COG0583	DNA-binding transcription factor activity
M4S28_23450	COG2116	formate transmembrane transporter activity
M4S28_23455	COG2353	YceI-like domain
M4S28_23460	COG3038	cytochrome b561
M4S28_23475	COG2200	EAL domain
M4S28_23500	COG0513	Belongs to the DEAD box helicase family
M4S28_23505	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
M4S28_23510	COG0814	amino acid
M4S28_23515	COG0840	transmembrane signaling receptor activity
M4S28_23520	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M4S28_23525	COG0784	Response regulator, receiver
M4S28_23525	COG3437	response regulator, receiver
M4S28_23570	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M4S28_23575	COG2759	Belongs to the formate--tetrahydrofolate ligase family
M4S28_23580	COG3706	GGDEF domain
M4S28_23585	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M4S28_23625	COG0509	glycine decarboxylation via glycine cleavage system
M4S28_23650	COG0534	Mate efflux family protein
M4S28_23715	COG2807	transmembrane transport
M4S28_23725	COG1881	PFAM PEBP family protein
M4S28_23730	COG5002	protein histidine kinase activity
M4S28_23795	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M4S28_23800	COG0784	Response regulator, receiver
M4S28_23800	COG2205	protein histidine kinase activity
M4S28_23805	COG1538	Outer membrane efflux protein
M4S28_23810	COG1132	(ABC) transporter
M4S28_23825	COG2205	protein histidine kinase activity
M4S28_23825	COG5002	protein histidine kinase activity
M4S28_23825	COG0784	Response regulator, receiver
M4S28_23840	COG0405	Gamma-glutamyltransferase
M4S28_23850	COG0641	radical SAM
M4S28_23875	COG3300	MHYT domain
M4S28_23875	COG5001	Diguanylate cyclase
M4S28_23880	COG0583	DNA-binding transcription factor activity
M4S28_23910	COG0714	Associated with various cellular activities
M4S28_23920	COG3119	arylsulfatase activity
M4S28_23925	COG3119	arylsulfatase activity
M4S28_23935	COG2205	protein histidine kinase activity
M4S28_23935	COG0784	Response regulator, receiver
M4S28_23945	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
M4S28_23960	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
M4S28_23965	COG2197	response regulator
M4S28_23980	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
M4S28_24010	COG0384	phenazine biosynthesis protein PhzF
M4S28_24015	COG1280	lysine exporter protein (LysE YggA)
M4S28_24025	COG3300	MHYT domain
M4S28_24025	COG5001	Diguanylate cyclase
M4S28_24045	COG3278	Belongs to the heme-copper respiratory oxidase family
M4S28_24085	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M4S28_24095	COG1012	belongs to the aldehyde dehydrogenase family
M4S28_24105	COG0583	DNA-binding transcription factor activity
M4S28_24115	COG0356	it plays a direct role in the translocation of protons across the membrane
M4S28_24130	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
M4S28_24140	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
M4S28_24150	COG0355	proton-transporting ATP synthase activity, rotational mechanism
M4S28_24160	COG0583	DNA-binding transcription factor activity
M4S28_24170	COG4172	Belongs to the ABC transporter superfamily
M4S28_24175	COG4239	(ABC) transporter, permease
M4S28_24180	COG4174	ABC transporter (Permease)
M4S28_24185	COG4166	transmembrane transport
M4S28_24205	COG1869	D-ribose catabolic process
M4S28_24210	COG1129	ABC transporter
M4S28_24215	COG1172	Belongs to the binding-protein-dependent transport system permease family
M4S28_24220	COG1879	ABC-type sugar transport system periplasmic component
M4S28_24225	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M4S28_24230	COG1609	Transcriptional regulator
M4S28_24260	COG3941	tape measure
M4S28_24305	COG0488	(ABC) transporter
M4S28_24345	COG0583	DNA-binding transcription factor activity
M4S28_24380	COG2026	Addiction module toxin, RelE StbE family
M4S28_24415	COG0517	IMP dehydrogenase activity
M4S28_24425	COG0517	IMP dehydrogenase activity
M4S28_24440	COG0243	molybdopterin cofactor binding
M4S28_24445	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M4S28_24455	COG2223	nitrite transmembrane transporter activity
M4S28_24460	COG0515	serine threonine protein kinase
M4S28_24460	COG2815	serine threonine protein kinase
M4S28_24465	COG1609	Transcriptional regulator
M4S28_24470	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
M4S28_24470	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
M4S28_24475	COG1105	Belongs to the carbohydrate kinase PfkB family
M4S28_24480	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M4S28_24480	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M4S28_24480	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
M4S28_24515	COG0745	RESPONSE REGULATOR receiver
M4S28_24535	COG0625	glutathione transferase activity
M4S28_24550	COG2223	nitrite transmembrane transporter activity
M4S28_24575	COG1879	ABC-type sugar transport system periplasmic component
M4S28_24580	COG1803	Methylglyoxal synthase
M4S28_24590	COG0210	DNA helicase
M4S28_24595	COG1289	transmembrane transporter activity
M4S28_24615	COG0583	DNA-binding transcription factor activity
M4S28_24620	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
M4S28_24625	COG1328	CTP reductase activity
M4S28_24655	COG1011	Hydrolase
M4S28_24665	COG1454	alcohol dehydrogenase
M4S28_24720	COG1063	alcohol dehydrogenase
M4S28_24725	COG0156	8-amino-7-oxononanoate synthase activity
M4S28_24730	COG2200	EAL domain
M4S28_24740	COG1136	(ABC) transporter
M4S28_24740	COG0577	efflux transmembrane transporter activity
M4S28_24745	COG1136	(ABC) transporter
M4S28_24745	COG0577	efflux transmembrane transporter activity
M4S28_24750	COG0577	efflux transmembrane transporter activity
M4S28_24750	COG1136	(ABC) transporter
M4S28_24760	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M4S28_24775	COG0346	lactoylglutathione lyase activity
M4S28_24795	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
M4S28_24800	COG3706	GGDEF domain
M4S28_24800	COG5001	Diguanylate cyclase
M4S28_24800	COG4251	negative regulation of phosphorylation
M4S28_24800	COG2203	Gaf domain
M4S28_24805	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
M4S28_24820	COG0393	Putative heavy-metal-binding
M4S28_24825	COG0739	heme binding
M4S28_24850	COG1132	(ABC) transporter
M4S28_24855	COG1132	(ABC) transporter
M4S28_24870	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
M4S28_24890	COG1760	l-serine dehydratase
M4S28_24895	COG3104	oligopeptide transport
M4S28_24900	COG2375	cellular response to nickel ion
M4S28_24905	COG1609	Transcriptional regulator
M4S28_24910	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
M4S28_24915	COG3265	gluconokinase activity
M4S28_24920	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
M4S28_24930	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
M4S28_24950	COG3842	ATPase activity
M4S28_24955	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M4S28_24960	COG1840	ABC-type Fe3 transport system, periplasmic component
M4S28_24970	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
M4S28_24985	COG1765	OsmC-like protein
M4S28_24990	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
M4S28_24990	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
M4S28_24995	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
M4S28_25000	COG0569	domain protein
M4S28_25005	COG0668	transmembrane transport
M4S28_25015	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M4S28_25020	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
M4S28_25025	COG3530	Putative quorum-sensing-regulated virulence factor
M4S28_25045	COG0109	protoheme IX farnesyltransferase activity
M4S28_25050	COG1612	heme a metabolic process
M4S28_25070	COG1845	cytochrome c oxidase, subunit III
M4S28_25080	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
M4S28_25090	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M4S28_25095	COG1280	lysine exporter protein (LysE YggA)
M4S28_25100	COG0179	Fumarylacetoacetate (FAA) hydrolase
M4S28_25110	COG0443	Heat shock 70 kDa protein
M4S28_25140	COG2827	Endonuclease containing a URI domain
M4S28_25145	COG3132	Protein of unknown function, DUF480
M4S28_25155	COG2926	Belongs to the UPF0265 family
M4S28_25180	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M4S28_25185	COG1151	hydroxylamine reductase activity
M4S28_25200	COG1280	lysine exporter protein (LysE YggA)
M4S28_25215	COG0531	amino acid
M4S28_25230	COG4413	Urea transporter
M4S28_25260	COG0714	Associated with various cellular activities
M4S28_25275	COG0641	radical SAM
M4S28_25280	COG3119	arylsulfatase activity
M4S28_25285	COG0300	oxidoreductase activity
M4S28_25290	COG2197	response regulator
M4S28_25295	COG1028	Short-chain dehydrogenase reductase Sdr
M4S28_25340	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
M4S28_25345	COG0402	S-adenosylhomocysteine deaminase activity
M4S28_25350	COG1278	Cold shock
M4S28_25355	COG3706	GGDEF domain
M4S28_25370	COG0513	Belongs to the DEAD box helicase family
M4S28_25390	COG0642	Histidine kinase
M4S28_25395	COG0745	RESPONSE REGULATOR receiver
M4S28_25420	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
M4S28_25435	COG3037	sugar-specific permease SgaT UlaA
M4S28_25445	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
M4S28_25450	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M4S28_25455	COG2205	protein histidine kinase activity
M4S28_25460	COG0745	RESPONSE REGULATOR receiver
M4S28_25465	COG5001	Diguanylate cyclase
M4S28_25475	COG5001	Diguanylate cyclase
M4S28_25485	COG1131	(ABC) transporter
M4S28_25505	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M4S28_25505	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M4S28_25515	COG0564	pseudouridine synthase activity
M4S28_25530	COG5464	transposase or invertase
M4S28_25535	COG1192	Involved in chromosome partitioning
M4S28_25635	COG0741	lytic transglycosylase activity
M4S28_25860	COG0583	DNA-binding transcription factor activity
M4S28_25880	COG3344	reverse transcriptase
M4S28_25930	COG1028	Short-chain dehydrogenase reductase Sdr
M4S28_25940	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M4S28_25945	COG4605	iron ion homeostasis
M4S28_25950	COG4607	ABC-type enterochelin transport system periplasmic component
M4S28_25955	COG4774	siderophore transport
M4S28_25960	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M4S28_25980	COG0076	glutamate decarboxylase activity
M4S28_26000	COG1169	isochorismate synthase
M4S28_26005	COG1021	2,3-dihydroxybenzoate-AMP ligase
M4S28_26010	COG3433	isochorismatase activity
M4S28_26010	COG1535	isochorismatase
M4S28_26015	COG4604	ABC transporter, ATP-binding protein
M4S28_26065	COG0488	(ABC) transporter
M4S28_26110	COG3941	tape measure
M4S28_26150	COG2003	Belongs to the UPF0758 family
M4S28_26200	COG0210	DNA helicase
M4S28_26310	COG0776	regulation of translation
M4S28_26330	COG0848	biopolymer transport protein
M4S28_26335	COG0811	peptide transport
M4S28_26340	COG0811	peptide transport
M4S28_26355	COG3344	reverse transcriptase