locus-tag	class	description
J4N39_00010	COG0592	DNA-directed DNA polymerase activity
J4N39_00020	COG0187	DNA topoisomerase II activity
J4N39_00025	COG2814	Major facilitator Superfamily
J4N39_00030	COG0583	DNA-binding transcription factor activity
J4N39_00040	COG0129	dihydroxy-acid dehydratase activity
J4N39_00045	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
J4N39_00050	COG3978	acetolactate synthase activity
J4N39_00060	COG0606	chelatase, subunit chli
J4N39_00070	COG0204	Acyl-transferase
J4N39_00075	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
J4N39_00080	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
J4N39_00090	COG3084	Protein conserved in bacteria
J4N39_00100	COG4326	sporulation control protein
J4N39_00105	COG1272	protein, Hemolysin III
J4N39_00110	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
J4N39_00115	COG0569	domain protein
J4N39_00120	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
J4N39_00120	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
J4N39_00125	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
J4N39_00135	COG1652	LysM domain
J4N39_00140	COG0758	DNA mediated transformation
J4N39_00145	COG2922	Belongs to the Smg family
J4N39_00150	COG0551	DNA topoisomerase type I activity
J4N39_00155	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
J4N39_00160	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
J4N39_00165	COG0009	L-threonylcarbamoyladenylate synthase
J4N39_00170	COG0408	coproporphyrinogen oxidase activity
J4N39_00175	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
J4N39_00185	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
J4N39_00245	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
J4N39_00250	COG1280	lysine exporter protein (LysE YggA)
J4N39_00255	COG2962	Rard protein
J4N39_00260	COG0514	ATP-dependent DNA helicase (RecQ)
J4N39_00270	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
J4N39_00280	COG0248	Ppx GppA phosphatase
J4N39_00290	COG3118	belongs to the thioredoxin family
J4N39_00305	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
J4N39_00355	COG1595	DNA-templated transcription, initiation
J4N39_00370	COG3071	HemY protein
J4N39_00375	COG2959	enzyme of heme biosynthesis
J4N39_00380	COG1587	Uroporphyrinogen-III synthase
J4N39_00395	COG1965	Belongs to the frataxin family
J4N39_00405	COG0019	diaminopimelate decarboxylase activity
J4N39_00410	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
J4N39_00420	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
J4N39_00425	COG1011	Hydrolase
J4N39_00430	COG3287	FIST C domain
J4N39_00430	COG2199	diguanylate cyclase activity
J4N39_00430	COG2200	EAL domain
J4N39_00450	COG0561	phosphatase activity
J4N39_00455	COG2267	carboxylic ester hydrolase activity
J4N39_00460	COG1280	lysine exporter protein (LysE YggA)
J4N39_00465	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
J4N39_00475	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
J4N39_00515	COG2095	MarC family integral membrane protein
J4N39_00525	COG0742	ribosomal rna small subunit methyltransferase
J4N39_00530	COG0552	protein localization to endoplasmic reticulum
J4N39_00535	COG2884	Cell division ATP-binding protein ftsE
J4N39_00540	COG2177	Part of the ABC transporter FtsEX involved in
J4N39_00555	COG0705	Rhomboid family
J4N39_00565	COG3161	chorismate lyase activity
J4N39_00570	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
J4N39_00575	COG2937	Belongs to the GPAT DAPAT family
J4N39_00580	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
J4N39_00585	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
J4N39_00590	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
J4N39_00595	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
J4N39_00600	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
J4N39_00605	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
J4N39_00620	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
J4N39_00625	COG4206	TonB-dependent receptor
J4N39_00635	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
J4N39_00725	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
J4N39_00735	COG0812	UDP-N-acetylmuramate dehydrogenase activity
J4N39_00740	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
J4N39_00740	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
J4N39_00745	COG1072	(Pantothenic acid kinase))
J4N39_00770	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
J4N39_00775	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
J4N39_00780	COG0250	Participates in transcription elongation, termination and antitermination
J4N39_00815	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
J4N39_00825	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
J4N39_00830	COG1573	uracil-dna glycosylase
J4N39_00835	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
J4N39_00850	COG1253	flavin adenine dinucleotide binding
J4N39_00865	COG0151	Belongs to the GarS family
J4N39_00880	COG0840	transmembrane signaling receptor activity
J4N39_00885	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
J4N39_00890	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
J4N39_00895	COG2264	protein methyltransferase activity
J4N39_00900	COG0439	Biotin carboxylase
J4N39_00905	COG0511	ligase activity, forming carbon-carbon bonds
J4N39_00910	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
J4N39_00915	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
J4N39_00930	COG2814	Major facilitator Superfamily
J4N39_00935	COG0784	Response regulator, receiver
J4N39_00935	COG2198	Histidine kinase
J4N39_00935	COG2205	protein histidine kinase activity
J4N39_00940	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
J4N39_00950	COG2095	MarC family integral membrane protein
J4N39_00965	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
J4N39_00970	COG1027	Aspartate ammonia-lyase
J4N39_00975	COG3030	protein affecting phage T7 exclusion by the F plasmid
J4N39_00980	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
J4N39_00985	COG2205	protein histidine kinase activity
J4N39_00990	COG0745	RESPONSE REGULATOR receiver
J4N39_01020	COG0798	PFAM Bile acid sodium symporter
J4N39_01050	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
J4N39_01055	COG1494	fructose-1,6-bisphosphatase
J4N39_01060	COG3074	FtsZ-dependent cytokinesis
J4N39_01070	COG1575	Belongs to the MenA family. Type 1 subfamily
J4N39_01080	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
J4N39_01095	COG1609	Transcriptional regulator
J4N39_01100	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
J4N39_01105	COG0254	rRNA binding
J4N39_01110	COG0281	malic enzyme
J4N39_01120	COG0626	cystathionine gamma-synthase activity
J4N39_01125	COG0527	aspartate kinase activity
J4N39_01125	COG0460	homoserine dehydrogenase
J4N39_01130	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
J4N39_01140	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
J4N39_01145	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
J4N39_01150	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
J4N39_01155	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
J4N39_01160	COG0137	argininosuccinate synthase activity
J4N39_01165	COG0165	Argininosuccinate lyase
J4N39_01165	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
J4N39_01175	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
J4N39_01175	COG0678	peroxiredoxin activity
J4N39_01180	COG0583	DNA-binding transcription factor activity
J4N39_01185	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
J4N39_01220	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
J4N39_01230	COG0338	D12 class N6 adenine-specific DNA methyltransferase
J4N39_01235	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
J4N39_01240	COG0546	phosphoglycolate phosphatase activity
J4N39_01245	COG0180	Tryptophanyl-tRNA synthetase
J4N39_01260	COG0512	Glutamine amidotransferase of anthranilate synthase
J4N39_01265	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
J4N39_01285	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
J4N39_01290	COG3954	Phosphoribulokinase
J4N39_01300	COG0429	hydrolase of the alpha beta-hydrolase fold
J4N39_01310	COG0488	(ABC) transporter
J4N39_01315	COG2249	NAD(P)H dehydrogenase (quinone) activity
J4N39_01330	COG1047	Peptidyl-prolyl cis-trans
J4N39_01345	COG0545	Peptidyl-prolyl cis-trans isomerase
J4N39_01350	COG2964	Protein conserved in bacteria
J4N39_01355	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
J4N39_01360	COG2923	Belongs to the DsrF TusC family
J4N39_01380	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
J4N39_01385	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
J4N39_01400	COG0051	transcription antitermination factor activity, RNA binding
J4N39_01405	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
J4N39_01410	COG0088	Forms part of the polypeptide exit tunnel
J4N39_01425	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
J4N39_01430	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
J4N39_01435	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
J4N39_01440	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
J4N39_01450	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
J4N39_01455	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
J4N39_01460	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
J4N39_01465	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
J4N39_01470	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
J4N39_01475	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
J4N39_01480	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
J4N39_01485	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
J4N39_01495	COG1841	ribosomal large subunit assembly
J4N39_01500	COG0200	Binds to the 23S rRNA
J4N39_01505	COG0201	protein transport
J4N39_01510	COG0257	Belongs to the bacterial ribosomal protein bL36 family
J4N39_01515	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
J4N39_01530	COG0202	RNA polymerase activity
J4N39_01535	COG0203	ribosomal protein L17
J4N39_01540	COG2873	o-acetylhomoserine
J4N39_01550	COG0545	Peptidyl-prolyl cis-trans isomerase
J4N39_01560	COG2153	protein acetylation
J4N39_01565	COG0737	Belongs to the 5'-nucleotidase family
J4N39_01570	COG1648	precorrin-2 dehydrogenase activity
J4N39_01570	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
J4N39_01575	COG0175	sulfate reduction
J4N39_01580	COG2895	sulfate adenylyltransferase (ATP) activity
J4N39_01585	COG3273	potassium ion transport
J4N39_01585	COG0471	metal ion transport
J4N39_01590	COG0529	Catalyzes the synthesis of activated sulfate
J4N39_01610	COG1136	(ABC) transporter
J4N39_01610	COG0577	efflux transmembrane transporter activity
J4N39_01625	COG0540	Belongs to the ATCase OTCase family
J4N39_01670	COG0525	valine-tRNA ligase activity
J4N39_01675	COG2927	DNA polymerase III (CHI subunit)
J4N39_01685	COG0795	lipopolysaccharide-transporting ATPase activity
J4N39_01690	COG0795	lipopolysaccharide-transporting ATPase activity
J4N39_01715	COG2199	diguanylate cyclase activity
J4N39_01715	COG2203	Gaf domain
J4N39_01790	COG2814	Major facilitator Superfamily
J4N39_01865	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
J4N39_01870	COG1194	a g-specific adenine glycosylase
J4N39_01875	COG0220	tRNA (guanine-N7-)-methyltransferase activity
J4N39_01880	COG2066	Belongs to the glutaminase family
J4N39_01885	COG0840	transmembrane signaling receptor activity
J4N39_01895	COG0635	Involved in the biosynthesis of porphyrin-containing compound
J4N39_01900	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
J4N39_01915	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
J4N39_01920	COG1872	DUF167
J4N39_01925	COG0762	integral membrane protein
J4N39_01930	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
J4N39_01935	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
J4N39_01950	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
J4N39_01955	COG1678	Uncharacterized ACR, COG1678
J4N39_01960	COG0189	ligase activity
J4N39_01965	COG1385	rRNA (uridine-N3-)-methyltransferase activity
J4N39_01970	COG2356	endonuclease I
J4N39_01990	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
J4N39_02010	COG0668	transmembrane transport
J4N39_02035	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
J4N39_02040	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
J4N39_02045	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
J4N39_02055	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
J4N39_02060	COG3079	Belongs to the UPF0149 family
J4N39_02065	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
J4N39_02070	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
J4N39_02090	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
J4N39_02095	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
J4N39_02100	COG1595	DNA-templated transcription, initiation
J4N39_02105	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
J4N39_02120	COG0481	GTPase activity
J4N39_02130	COG0571	ribonuclease III activity
J4N39_02135	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
J4N39_02140	COG1381	Involved in DNA repair and RecF pathway recombination
J4N39_02145	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
J4N39_02170	COG4999	Histidine kinase
J4N39_02170	COG3850	Histidine kinase
J4N39_02170	COG3437	response regulator, receiver
J4N39_02170	COG2205	protein histidine kinase activity
J4N39_02175	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
J4N39_02180	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
J4N39_02185	COG3956	TIGRFAM MazG family protein
J4N39_02195	COG0148	phosphopyruvate hydratase activity
J4N39_02205	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
J4N39_02215	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
J4N39_02220	COG0585	pseudouridine synthase activity
J4N39_02225	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
J4N39_02230	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
J4N39_02235	COG4942	peptidase
J4N39_02235	COG1388	LysM domain
J4N39_02240	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
J4N39_02245	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
J4N39_02260	COG2255	four-way junction helicase activity
J4N39_02265	COG3853	Toxic anion resistance protein (TelA)
J4N39_02270	COG1546	Belongs to the CinA family
J4N39_02275	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
J4N39_02280	COG2137	regulation of response to DNA damage stimulus
J4N39_02290	COG0527	aspartate kinase activity
J4N39_02295	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
J4N39_02345	COG3630	sodium ion export across plasma membrane
J4N39_02355	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
J4N39_02365	COG1238	metal cluster binding
J4N39_02370	COG0612	Peptidase, M16
J4N39_02385	COG1854	S-ribosylhomocysteine lyase activity
J4N39_02390	COG4536	flavin adenine dinucleotide binding
J4N39_02395	COG4137	Cytochrome C assembly protein
J4N39_02400	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
J4N39_02410	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
J4N39_02415	COG0336	Belongs to the RNA methyltransferase TrmD family
J4N39_02425	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
J4N39_02430	COG0505	Belongs to the CarA family
J4N39_02435	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
J4N39_02450	COG0730	response to heat
J4N39_02460	COG2860	membrane
J4N39_02470	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
J4N39_02475	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
J4N39_02485	COG0493	'glutamate synthase
J4N39_02490	COG0067	glutamate synthase
J4N39_02490	COG0069	glutamate synthase activity
J4N39_02490	COG0070	glutamate synthase
J4N39_02500	COG0069	glutamate synthase activity
J4N39_02500	COG0067	glutamate synthase
J4N39_02500	COG0070	glutamate synthase
J4N39_02510	COG1242	4 iron, 4 sulfur cluster binding
J4N39_02515	COG0784	Response regulator, receiver
J4N39_02515	COG2198	Histidine kinase
J4N39_02515	COG5002	protein histidine kinase activity
J4N39_02525	COG0745	RESPONSE REGULATOR receiver
J4N39_02535	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
J4N39_02550	COG0083	homoserine kinase activity
J4N39_02555	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
J4N39_02560	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
J4N39_02570	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
J4N39_02585	COG1115	amino acid carrier protein
J4N39_02590	COG3022	response to hydroperoxide
J4N39_02595	COG0513	Belongs to the DEAD box helicase family
J4N39_02610	COG0716	FMN binding
J4N39_02615	COG4974	Belongs to the 'phage' integrase family
J4N39_02625	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
J4N39_02635	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
J4N39_02640	COG1283	sodium-dependent phosphate transmembrane transporter activity
J4N39_02645	COG0583	DNA-binding transcription factor activity
J4N39_02650	COG0640	Transcriptional regulator
J4N39_02655	COG0488	(ABC) transporter
J4N39_02665	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
J4N39_02670	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
J4N39_02675	COG0077	Prephenate dehydratase
J4N39_02675	COG1605	Chorismate mutase
J4N39_02680	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
J4N39_02685	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
J4N39_02690	COG0564	pseudouridine synthase activity
J4N39_02700	COG0542	response to heat
J4N39_02755	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
J4N39_02760	COG0826	peptidase U32
J4N39_02765	COG2974	May be involved in recombination
J4N39_02770	COG0745	RESPONSE REGULATOR receiver
J4N39_02775	COG5002	protein histidine kinase activity
J4N39_02785	COG0248	Ppx GppA phosphatase
J4N39_02790	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
J4N39_02800	COG0581	inorganic phosphate transmembrane transporter activity
J4N39_02805	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
J4N39_02810	COG0704	Plays a role in the regulation of phosphate uptake
J4N39_02820	COG3142	Participates in the control of copper homeostasis
J4N39_02825	COG0450	alkyl hydroperoxide reductase
J4N39_02830	COG0583	DNA-binding transcription factor activity
J4N39_02835	COG0517	IMP dehydrogenase activity
J4N39_02840	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
J4N39_02845	COG0343	queuine tRNA-ribosyltransferase activity
J4N39_02850	COG1862	Preprotein translocase
J4N39_02855	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
J4N39_02860	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
J4N39_02880	COG0483	inositol monophosphate 1-phosphatase activity
J4N39_02885	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
J4N39_02890	COG1959	2 iron, 2 sulfur cluster binding
J4N39_02895	COG1104	cysteine desulfurase activity
J4N39_02900	COG0822	iron-sulfur transferase activity
J4N39_02905	COG0316	Belongs to the HesB IscA family
J4N39_02915	COG0443	Heat shock 70 kDa protein
J4N39_02920	COG0633	Ferredoxin
J4N39_02925	COG2975	iron-sulfur cluster assembly
J4N39_02930	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
J4N39_02960	COG0124	histidyl-tRNA synthetase
J4N39_02965	COG2976	Protein conserved in bacteria
J4N39_02970	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
J4N39_02975	COG1160	GTP binding
J4N39_02980	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
J4N39_02990	COG1570	exodeoxyribonuclease VII activity
J4N39_02995	COG0516	GMP reductase activity
J4N39_02995	COG0517	IMP dehydrogenase activity
J4N39_03000	COG0518	GMP synthase (glutamine-hydrolyzing) activity
J4N39_03000	COG0519	Catalyzes the synthesis of GMP from XMP
J4N39_03020	COG1584	GPR1 FUN34 yaaH family protein
J4N39_03025	COG1115	amino acid carrier protein
J4N39_03045	COG0513	Belongs to the DEAD box helicase family
J4N39_03085	COG1396	sequence-specific DNA binding
J4N39_03100	COG2867	negative regulation of translational initiation
J4N39_03105	COG2914	Belongs to the UPF0125 (RnfH) family
J4N39_03110	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
J4N39_03115	COG0497	DNA recombination
J4N39_03120	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
J4N39_03125	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
J4N39_03135	COG0484	heat shock protein binding
J4N39_03160	COG0395	ABC-type sugar transport system, permease component
J4N39_03165	COG3842	ATPase activity
J4N39_03170	COG3459	Glycosyltransferase 36 associated
J4N39_03175	COG2017	converts alpha-aldose to the beta-anomer
J4N39_03185	COG1609	Transcriptional regulator
J4N39_03190	COG0840	transmembrane signaling receptor activity
J4N39_03220	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
J4N39_03235	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
J4N39_03240	COG0047	phosphoribosylformylglycinamidine synthase activity
J4N39_03240	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
J4N39_03270	COG2195	Cleaves the N-terminal amino acid of tripeptides
J4N39_03275	COG2252	PERMEase
J4N39_03280	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
J4N39_03285	COG1073	alpha beta
J4N39_03295	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
J4N39_03300	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
J4N39_03305	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
J4N39_03310	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
J4N39_03310	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
J4N39_03335	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
J4N39_03340	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
J4N39_03345	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
J4N39_03360	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
J4N39_03365	COG0142	geranyltranstransferase activity
J4N39_03375	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
J4N39_03380	COG2885	chlorophyll binding
J4N39_03385	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
J4N39_03385	COG0301	tRNA thio-modification
J4N39_03390	COG0583	DNA-binding transcription factor activity
J4N39_03400	COG2363	Small membrane protein
J4N39_03405	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
J4N39_03415	COG1611	Belongs to the LOG family
J4N39_03430	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
J4N39_03430	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
J4N39_03440	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
J4N39_03470	COG0564	pseudouridine synthase activity
J4N39_03485	COG0583	DNA-binding transcription factor activity
J4N39_03490	COG1574	metal-dependent hydrolase with the TIM-barrel fold
J4N39_03500	COG0330	HflC and HflK could
J4N39_03505	COG0330	HflC and HflK could
J4N39_03515	COG1733	regulation of RNA biosynthetic process
J4N39_03525	COG0024	Methionine aminopeptidase
J4N39_03540	COG0528	UMP kinase activity
J4N39_03545	COG0233	cytoplasmic translational termination
J4N39_03550	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
J4N39_03555	COG0575	Belongs to the CDS family
J4N39_03565	COG0750	zinc metalloprotease
J4N39_03575	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
J4N39_03580	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
J4N39_03585	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
J4N39_03605	COG0587	DNA-directed DNA polymerase activity
J4N39_03610	COG0825	malonyl-CoA metabolic process
J4N39_03630	COG0347	Belongs to the P(II) protein family
J4N39_03635	COG3021	interspecies interaction between organisms
J4N39_03640	COG1388	LysM domain
J4N39_03640	COG0741	lytic transglycosylase activity
J4N39_03645	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
J4N39_03650	COG2226	methyltransferase
J4N39_03685	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
J4N39_03690	COG0121	glutamine amidotransferase
J4N39_03695	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
J4N39_03700	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
J4N39_03705	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
J4N39_03730	COG1393	Belongs to the ArsC family
J4N39_03735	COG4783	chaperone-mediated protein folding
J4N39_03750	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
J4N39_03755	COG2716	regulation of RNA biosynthetic process
J4N39_03760	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
J4N39_03765	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
J4N39_03775	COG1876	peptidase activity
J4N39_03785	COG1393	Belongs to the ArsC family
J4N39_03810	COG2837	iron assimilation
J4N39_03820	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
J4N39_03825	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
J4N39_03830	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
J4N39_03835	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
J4N39_03850	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
J4N39_03860	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
J4N39_03870	COG1516	flagellar protein fliS
J4N39_03890	COG1677	Flagellar hook-basal body complex protein FliE
J4N39_03900	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
J4N39_03910	COG1157	protein secretion by the type III secretion system
J4N39_03950	COG1987	bacterial-type flagellum assembly
J4N39_03955	COG1684	flagellar biosynthetic protein fliR
J4N39_03990	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
J4N39_03995	COG0643	Histidine kinase
J4N39_03995	COG2198	Histidine kinase
J4N39_03995	COG0784	Response regulator, receiver
J4N39_04000	COG2201	protein-glutamate methylesterase activity
J4N39_04005	COG1192	Involved in chromosome partitioning
J4N39_04015	COG0835	chemotaxis
J4N39_04025	COG4133	protoheme IX ABC transporter activity
J4N39_04030	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
J4N39_04035	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
J4N39_04050	COG1138	Cytochrome C-type biogenesis protein
J4N39_04055	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
J4N39_04065	COG3088	subunit of a heme lyase
J4N39_04065	COG4235	cytochrome complex assembly
J4N39_04080	COG2067	long-chain fatty acid transport protein
J4N39_04095	COG0183	Belongs to the thiolase family
J4N39_04100	COG1024	Enoyl-CoA hydratase
J4N39_04100	COG1250	3-hydroxyacyl-CoA dehydrogenase
J4N39_04105	COG1025	Belongs to the peptidase M16 family
J4N39_04110	COG2062	phosphohistidine phosphatase, SixA
J4N39_04115	COG2840	Smr protein MutS2
J4N39_04120	COG2890	protein-(glutamine-N5) methyltransferase activity
J4N39_04125	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
J4N39_04135	COG3101	peptidyl-lysine hydroxylation
J4N39_04150	COG3093	addiction module antidote protein HigA
J4N39_04160	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
J4N39_04165	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
J4N39_04170	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
J4N39_04180	COG0101	tRNA pseudouridine synthase activity
J4N39_04185	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
J4N39_04190	COG0285	dihydrofolate synthase activity
J4N39_04195	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
J4N39_04200	COG1286	toxin biosynthetic process
J4N39_04205	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
J4N39_04215	COG0745	RESPONSE REGULATOR receiver
J4N39_04220	COG2832	Protein of unknown function (DUF454)
J4N39_04225	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
J4N39_04240	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
J4N39_04250	COG2983	Belongs to the UPF0260 family
J4N39_04275	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
J4N39_04285	COG1120	ATPase activity
J4N39_04295	COG4774	siderophore transport
J4N39_04300	COG3708	Transcriptional regulator
J4N39_04300	COG2207	Transcriptional regulator
J4N39_04305	COG2226	methyltransferase
J4N39_04315	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
J4N39_04320	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
J4N39_04330	COG3139	Protein of unknown function (DUF1315)
J4N39_04335	COG0252	asparaginase activity
J4N39_04340	COG0616	signal peptide processing
J4N39_04345	COG0446	pyridine nucleotide-disulphide oxidoreductase
J4N39_04345	COG1902	pentaerythritol trinitrate reductase activity
J4N39_04350	COG0778	Nitroreductase
J4N39_04355	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
J4N39_04365	COG0840	transmembrane signaling receptor activity
J4N39_04375	COG5001	Diguanylate cyclase
J4N39_04380	COG0123	including yeast histone deacetylase and acetoin utilization protein
J4N39_04390	COG2067	long-chain fatty acid transport protein
J4N39_04430	COG3081	Nucleoid-associated protein
J4N39_04445	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
J4N39_04450	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
J4N39_04455	COG2095	MarC family integral membrane protein
J4N39_04460	COG1454	alcohol dehydrogenase
J4N39_04460	COG1012	belongs to the aldehyde dehydrogenase family
J4N39_04470	COG4232	protein-disulfide reductase activity
J4N39_04475	COG3118	belongs to the thioredoxin family
J4N39_04500	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
J4N39_04505	COG0584	glycerophosphoryl diester phosphodiesterase
J4N39_04510	COG1349	DNA-binding transcription factor activity
J4N39_04515	COG3842	ATPase activity
J4N39_04520	COG0395	ABC-type sugar transport system, permease component
J4N39_04525	COG1175	transmembrane transport
J4N39_04535	COG2056	Na+-H+ antiporter family
J4N39_04540	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
J4N39_04545	COG2885	chlorophyll binding
J4N39_04555	COG0346	lactoylglutathione lyase activity
J4N39_04560	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
J4N39_04565	COG4660	Part of a membrane complex involved in electron transport
J4N39_04570	COG4659	FMN binding
J4N39_04575	COG4658	electron transport chain
J4N39_04580	COG4656	Part of a membrane complex involved in electron transport
J4N39_04585	COG2878	Part of a membrane complex involved in electron transport
J4N39_04590	COG4657	Part of a membrane complex involved in electron transport
J4N39_04595	COG3250	beta-galactosidase activity
J4N39_04610	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
J4N39_04630	COG0556	nucleotide-excision repair
J4N39_04635	COG2204	response regulator
J4N39_04640	COG2198	Histidine kinase
J4N39_04645	COG0391	Required for morphogenesis under gluconeogenic growth conditions
J4N39_04650	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
J4N39_04655	COG0521	Mo-molybdopterin cofactor biosynthetic process
J4N39_04660	COG0315	cyclic pyranopterin monophosphate synthase activity
J4N39_04665	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
J4N39_04670	COG0314	molybdopterin synthase activity
J4N39_04685	COG0601	transmembrane transport
J4N39_04690	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
J4N39_04695	COG0444	Belongs to the ABC transporter superfamily
J4N39_04705	COG0534	Mate efflux family protein
J4N39_04710	COG0435	Glutathione S-transferase
J4N39_04715	COG5433	transposase activity
J4N39_04720	COG1280	lysine exporter protein (LysE YggA)
J4N39_04760	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
J4N39_04765	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
J4N39_04780	COG3681	Belongs to the UPF0597 family
J4N39_04785	COG1522	sequence-specific DNA binding
J4N39_04790	COG1946	Acyl-CoA thioesterase
J4N39_04795	COG3126	Type III secretion system lipoprotein chaperone (YscW)
J4N39_04820	COG1280	lysine exporter protein (LysE YggA)
J4N39_04845	COG2815	serine threonine protein kinase
J4N39_04845	COG0515	serine threonine protein kinase
J4N39_04870	COG1609	Transcriptional regulator
J4N39_04875	COG0366	Alpha amylase catalytic
J4N39_04885	COG0667	Aldo Keto reductase
J4N39_04890	COG0405	Gamma-glutamyltransferase
J4N39_04895	COG1609	Transcriptional regulator
J4N39_04915	COG2814	Major facilitator Superfamily
J4N39_04920	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
J4N39_04925	COG1760	l-serine dehydratase
J4N39_04950	COG0583	DNA-binding transcription factor activity
J4N39_04955	COG0840	transmembrane signaling receptor activity
J4N39_04960	COG4175	Glycine betaine
J4N39_04960	COG3448	diguanylate cyclase activity
J4N39_04965	COG4176	ABC-type proline glycine betaine transport system permease component
J4N39_04975	COG1858	cytochrome C peroxidase
J4N39_04980	COG2205	protein histidine kinase activity
J4N39_04980	COG0784	Response regulator, receiver
J4N39_04990	COG3706	GGDEF domain
J4N39_04995	COG0765	amino acid transport
J4N39_05010	COG1126	abc transporter atp-binding protein
J4N39_05020	COG0587	DNA-directed DNA polymerase activity
J4N39_05030	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
J4N39_05040	COG0784	Response regulator, receiver
J4N39_05040	COG0835	chemotaxis
J4N39_05045	COG5001	Diguanylate cyclase
J4N39_05045	COG3300	MHYT domain
J4N39_05060	COG0471	metal ion transport
J4N39_05075	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
J4N39_05080	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
J4N39_05095	COG0537	adenosine 5'-monophosphoramidase activity
J4N39_05120	COG3150	esterase
J4N39_05125	COG1252	NADH dehydrogenase
J4N39_05130	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
J4N39_05140	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
J4N39_05150	COG4591	ABC-type transport system involved in lipoprotein release permease component
J4N39_05155	COG1136	(ABC) transporter
J4N39_05160	COG4591	ABC-type transport system involved in lipoprotein release permease component
J4N39_05170	COG0658	competence protein
J4N39_05170	COG2333	competence protein COMEC
J4N39_05175	COG1132	(ABC) transporter
J4N39_05180	COG1663	tetraacyldisaccharide 4'-kinase activity
J4N39_05190	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
J4N39_05210	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
J4N39_05235	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
J4N39_05250	COG0463	Glycosyl transferase, family 2
J4N39_05255	COG2719	SpoVR family
J4N39_05260	COG2718	Belongs to the UPF0229 family
J4N39_05265	COG2766	serine protein kinase
J4N39_05285	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
J4N39_05295	COG1882	Formate acetyltransferase
J4N39_05320	COG4215	(ABC) transporter
J4N39_05325	COG4160	amino acid transport
J4N39_05330	COG0708	Exodeoxyribonuclease III
J4N39_05345	COG0583	DNA-binding transcription factor activity
J4N39_05350	COG0840	transmembrane signaling receptor activity
J4N39_05360	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
J4N39_05365	COG2915	High frequency lysogenization protein hflD homolog
J4N39_05370	COG0482	sulfurtransferase activity
J4N39_05375	COG1187	pseudouridine synthase activity
J4N39_05385	COG1278	Cold shock
J4N39_05390	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
J4N39_05395	COG0542	response to heat
J4N39_05400	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
J4N39_05405	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
J4N39_05420	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
J4N39_05430	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
J4N39_05440	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
J4N39_05445	COG0297	glycogen (starch) synthase activity
J4N39_05465	COG3070	regulator of competence-specific genes
J4N39_05470	COG1609	Transcriptional regulator
J4N39_05475	COG3381	protein complex oligomerization
J4N39_05480	COG0745	RESPONSE REGULATOR receiver
J4N39_05485	COG1434	Gram-negative-bacterium-type cell wall biogenesis
J4N39_05490	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
J4N39_05500	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
J4N39_05505	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
J4N39_05520	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
J4N39_05530	COG2116	formate transmembrane transporter activity
J4N39_05540	COG0390	transport system, permease component
J4N39_05555	COG4459	periplasmic nitrate reductase
J4N39_05560	COG3005	denitrification pathway
J4N39_05565	COG0243	molybdopterin cofactor binding
J4N39_05570	COG0840	transmembrane signaling receptor activity
J4N39_05575	COG1227	inorganic diphosphatase activity
J4N39_05590	COG1396	sequence-specific DNA binding
J4N39_05625	COG4172	Belongs to the ABC transporter superfamily
J4N39_05635	COG4171	peptide transport system, permease
J4N39_05650	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
J4N39_05655	COG1842	Phage shock protein A
J4N39_05675	COG1566	PFAM secretion protein HlyD family protein
J4N39_05680	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
J4N39_05685	COG0626	cystathionine gamma-synthase activity
J4N39_05695	COG0733	neurotransmitter:sodium symporter activity
J4N39_05700	COG0564	pseudouridine synthase activity
J4N39_05705	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
J4N39_05705	COG0116	Belongs to the methyltransferase superfamily
J4N39_05725	COG2350	Protein conserved in bacteria
J4N39_05740	COG0159	tryptophan synthase activity
J4N39_05745	COG0133	tryptophan synthase activity
J4N39_05750	COG0135	phosphoribosylanthranilate isomerase activity
J4N39_05750	COG0134	indole-3-glycerol-phosphate synthase activity
J4N39_05755	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
J4N39_05760	COG0512	Glutamine amidotransferase of anthranilate synthase
J4N39_05765	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
J4N39_05770	COG0613	PHP domain protein
J4N39_05775	COG0009	L-threonylcarbamoyladenylate synthase
J4N39_05800	COG2161	toxin-antitoxin pair type II binding
J4N39_05835	COG2814	Major facilitator Superfamily
J4N39_05940	COG3642	lipopolysaccharide core region biosynthetic process
J4N39_05955	COG0417	DNA replication proofreading
J4N39_05960	COG2197	response regulator
J4N39_05965	COG0322	excinuclease ABC activity
J4N39_05975	COG2199	diguanylate cyclase activity
J4N39_06015	COG2198	Histidine kinase
J4N39_06015	COG0784	Response regulator, receiver
J4N39_06015	COG0643	Histidine kinase
J4N39_06035	COG0019	diaminopimelate decarboxylase activity
J4N39_06040	COG0840	transmembrane signaling receptor activity
J4N39_06070	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
J4N39_06075	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
J4N39_06080	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
J4N39_06085	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
J4N39_06110	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
J4N39_06115	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
J4N39_06120	COG0437	4 iron, 4 sulfur cluster binding
J4N39_06125	COG3301	Polysulphide reductase, NrfD
J4N39_06130	COG1138	Cytochrome C-type biogenesis protein
J4N39_06140	COG3088	subunit of a heme lyase
J4N39_06140	COG4235	cytochrome complex assembly
J4N39_06150	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
J4N39_06175	COG2989	Protein conserved in bacteria
J4N39_06180	COG3108	Peptidase M15
J4N39_06185	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
J4N39_06200	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
J4N39_06225	COG1846	Transcriptional regulator
J4N39_06230	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
J4N39_06265	COG0724	RNA recognition motif
J4N39_06285	COG0724	RNA recognition motif
J4N39_06290	COG1160	GTP binding
J4N39_06295	COG3596	GTP binding
J4N39_06300	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
J4N39_06325	COG1454	alcohol dehydrogenase
J4N39_06325	COG1012	belongs to the aldehyde dehydrogenase family
J4N39_06335	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
J4N39_06345	COG2176	DNA-directed DNA polymerase activity
J4N39_06360	COG1448	Aminotransferase
J4N39_06365	COG2770	Histidine kinase
J4N39_06365	COG3437	response regulator, receiver
J4N39_06375	COG0017	Asparaginyl-tRNA synthetase
J4N39_06390	COG1760	l-serine dehydratase
J4N39_06395	COG0814	amino acid
J4N39_06400	COG0494	nUDIX hydrolase
J4N39_06405	COG0745	RESPONSE REGULATOR receiver
J4N39_06420	COG3106	COG3106 Predicted ATPase
J4N39_06425	COG3768	UPF0283 membrane protein
J4N39_06435	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
J4N39_06450	COG3214	Protein conserved in bacteria
J4N39_06455	COG0405	Gamma-glutamyltransferase
J4N39_06470	COG0697	spore germination
J4N39_06480	COG0443	Heat shock 70 kDa protein
J4N39_06485	COG0443	Heat shock 70 kDa protein
J4N39_06520	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
J4N39_06525	COG1643	Atp-dependent helicase
J4N39_06570	COG1280	lysine exporter protein (LysE YggA)
J4N39_06575	COG1063	alcohol dehydrogenase
J4N39_06585	COG1115	amino acid carrier protein
J4N39_06620	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
J4N39_06630	COG3290	protein histidine kinase activity
J4N39_06635	COG4565	transcriptional regulatory protein
J4N39_06670	COG0840	transmembrane signaling receptor activity
J4N39_06675	COG2731	YhcH YjgK YiaL family protein
J4N39_06685	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
J4N39_06690	COG0372	Belongs to the citrate synthase family
J4N39_06695	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
J4N39_06715	COG1051	belongs to the nudix hydrolase family
J4N39_06720	COG0602	queuosine metabolic process
J4N39_06730	COG3706	GGDEF domain
J4N39_06750	COG2885	chlorophyll binding
J4N39_06800	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
J4N39_06815	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
J4N39_06820	COG0670	Belongs to the BI1 family
J4N39_06825	COG1126	abc transporter atp-binding protein
J4N39_06830	COG0765	amino acid transport
J4N39_06835	COG4597	amino acid ABC transporter
J4N39_06840	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
J4N39_06850	COG1666	GTP binding
J4N39_06855	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
J4N39_06875	COG2996	Protein conserved in bacteria
J4N39_06885	COG3008	intermembrane lipid transfer
J4N39_06890	COG2995	paraquat-inducible protein a
J4N39_06895	COG1132	(ABC) transporter
J4N39_06900	COG1956	GAF domain-containing protein
J4N39_06905	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
J4N39_06910	COG0793	Belongs to the peptidase S41A family
J4N39_06920	COG0308	aminopeptidase N
J4N39_06930	COG2902	Dehydrogenase
J4N39_06935	COG0167	dihydroorotate dehydrogenase activity
J4N39_06955	COG0488	(ABC) transporter
J4N39_06970	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
J4N39_06975	COG1067	ATP-dependent peptidase activity
J4N39_06980	COG3120	sequence-specific DNA binding
J4N39_06995	COG2205	protein histidine kinase activity
J4N39_06995	COG0784	Response regulator, receiver
J4N39_07010	COG3278	Belongs to the heme-copper respiratory oxidase family
J4N39_07025	COG2010	Cytochrome c
J4N39_07035	COG2217	Heavy metal translocating P-type atpase
J4N39_07050	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
J4N39_07055	COG0589	response to stress
J4N39_07080	COG3842	ATPase activity
J4N39_07090	COG1177	transmembrane transport
J4N39_07100	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
J4N39_07105	COG3706	GGDEF domain
J4N39_07115	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
J4N39_07120	COG0004	ammonium transporteR
J4N39_07125	COG2864	formate dehydrogenase
J4N39_07130	COG0437	4 iron, 4 sulfur cluster binding
J4N39_07165	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
J4N39_07170	COG0840	transmembrane signaling receptor activity
J4N39_07175	COG3852	Histidine kinase
J4N39_07180	COG2204	response regulator
J4N39_07190	COG4662	Binding-protein-dependent transport system inner membrane component
J4N39_07200	COG0746	molybdenum cofactor guanylyltransferase activity
J4N39_07205	COG0303	'Molybdopterin
J4N39_07215	COG3083	sulfuric ester hydrolase activity
J4N39_07220	COG1940	carbohydrate kinase activity
J4N39_07225	COG3148	PFAM DTW domain containing protein
J4N39_07240	COG0791	NLP P60 protein
J4N39_07250	COG3706	GGDEF domain
J4N39_07270	COG0307	riboflavin synthase, alpha
J4N39_07275	COG0534	Mate efflux family protein
J4N39_07280	COG1793	dna ligase
J4N39_07295	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
J4N39_07315	COG0471	metal ion transport
J4N39_07330	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
J4N39_07335	COG0625	glutathione transferase activity
J4N39_07345	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
J4N39_07360	COG2195	Cleaves the N-terminal amino acid of tripeptides
J4N39_07395	COG4134	Bacterial extracellular solute-binding protein
J4N39_07400	COG4135	transport system, permease component
J4N39_07405	COG4136	ATPase activity
J4N39_07410	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
J4N39_07420	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
J4N39_07430	COG1451	nucleotide metabolic process
J4N39_07445	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
J4N39_07465	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
J4N39_07480	COG0583	DNA-binding transcription factor activity
J4N39_07535	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
J4N39_07540	COG4139	cobalamin transport
J4N39_07545	COG2988	succinylglutamate desuccinylase activity
J4N39_07560	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
J4N39_07565	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
J4N39_07570	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
J4N39_07575	COG0702	epimerase
J4N39_07580	COG1823	symporter activity
J4N39_07590	COG2925	Exonuclease
J4N39_07595	COG1380	Effector of murein hydrolase LrgA
J4N39_07600	COG1346	cytolysis
J4N39_07605	COG4607	ABC-type enterochelin transport system periplasmic component
J4N39_07610	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
J4N39_07615	COG4605	iron ion homeostasis
J4N39_07620	COG4604	ABC transporter, ATP-binding protein
J4N39_07625	COG3708	Transcriptional regulator
J4N39_07625	COG2207	Transcriptional regulator
J4N39_07640	COG0295	cytidine deaminase activity
J4N39_07645	COG2920	part of a sulfur-relay system
J4N39_07650	COG1254	Belongs to the acylphosphatase family
J4N39_07670	COG0577	efflux transmembrane transporter activity
J4N39_07670	COG1136	(ABC) transporter
J4N39_07690	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
J4N39_07690	COG0072	phenylalanine-tRNA ligase activity
J4N39_07710	COG3243	poly(R)-hydroxyalkanoic acid synthase
J4N39_07720	COG0183	Belongs to the thiolase family
J4N39_07735	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
J4N39_07770	COG1280	lysine exporter protein (LysE YggA)
J4N39_07790	COG1942	4-Oxalocrotonate Tautomerase
J4N39_07800	COG0454	-acetyltransferase
J4N39_07810	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
J4N39_07825	COG0488	(ABC) transporter
J4N39_07830	COG0668	transmembrane transport
J4N39_07850	COG1794	racemase activity, acting on amino acids and derivatives
J4N39_07865	COG3122	Protein conserved in bacteria
J4N39_07895	COG2824	Alkylphosphonate utilization operon protein PhnA
J4N39_07915	COG1028	Short-chain dehydrogenase reductase Sdr
J4N39_07925	COG4628	conserved protein (DUF2132)
J4N39_07935	COG0393	Putative heavy-metal-binding
J4N39_07980	COG2067	long-chain fatty acid transport protein
J4N39_07990	COG0110	maltose O-acetyltransferase activity
J4N39_08280	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
J4N39_08285	COG0291	Belongs to the bacterial ribosomal protein bL35 family
J4N39_08295	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
J4N39_08300	COG2188	Transcriptional regulator
J4N39_08310	COG0010	Belongs to the arginase family
J4N39_08315	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
J4N39_08340	COG0277	FAD linked oxidase domain protein
J4N39_08340	COG0247	lactate metabolic process
J4N39_08370	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
J4N39_08380	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
J4N39_08385	COG1643	Atp-dependent helicase
J4N39_08390	COG0281	malic enzyme
J4N39_08400	COG2949	membrane
J4N39_08405	COG3706	GGDEF domain
J4N39_08415	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
J4N39_08430	COG0492	ferredoxin-NADP+ reductase activity
J4N39_08435	COG4988	ABC transporter
J4N39_08440	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
J4N39_08445	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
J4N39_08455	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
J4N39_08455	COG4191	Histidine kinase
J4N39_08470	COG3070	regulator of competence-specific genes
J4N39_08480	COG2431	L-lysine efflux transmembrane transporter activity
J4N39_08490	COG0076	glutamate decarboxylase activity
J4N39_08495	COG1737	Transcriptional regulator
J4N39_08500	COG1454	alcohol dehydrogenase
J4N39_08505	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
J4N39_08515	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
J4N39_08520	COG1960	acyl-CoA dehydrogenase activity
J4N39_08530	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
J4N39_08545	COG1136	(ABC) transporter
J4N39_08555	COG0702	epimerase
J4N39_08565	COG2814	Major facilitator Superfamily
J4N39_08575	COG1061	Type III restriction enzyme res subunit
J4N39_08595	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
J4N39_08600	COG3313	Fe-S protein
J4N39_08630	COG0583	DNA-binding transcription factor activity
J4N39_08645	COG3069	C4-dicarboxylate transmembrane transporter activity
J4N39_08650	COG3300	MHYT domain
J4N39_08650	COG5001	Diguanylate cyclase
J4N39_08680	COG5433	transposase activity
J4N39_08775	COG3646	Phage regulatory protein
J4N39_08950	COG4712	double-strand break repair protein
J4N39_08970	COG0629	single-stranded DNA binding
J4N39_08990	COG0582	viral genome integration into host DNA
J4N39_09010	COG3300	MHYT domain
J4N39_09010	COG5001	Diguanylate cyclase
J4N39_09015	COG2201	protein-glutamate methylesterase activity
J4N39_09020	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
J4N39_09025	COG0835	chemotaxis
J4N39_09035	COG0840	transmembrane signaling receptor activity
J4N39_09040	COG0643	Histidine kinase
J4N39_09040	COG2198	Histidine kinase
J4N39_09050	COG0745	RESPONSE REGULATOR receiver
J4N39_09090	COG0641	radical SAM
J4N39_09120	COG2304	oxidoreductase activity
J4N39_09140	COG0714	Associated with various cellular activities
J4N39_09145	COG3119	arylsulfatase activity
J4N39_09160	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
J4N39_09175	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
J4N39_09185	COG4608	Belongs to the ABC transporter superfamily
J4N39_09190	COG0444	Belongs to the ABC transporter superfamily
J4N39_09195	COG0747	negative chemotaxis
J4N39_09200	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
J4N39_09205	COG0601	transmembrane transport
J4N39_09250	COG1012	belongs to the aldehyde dehydrogenase family
J4N39_09255	COG3284	Transcriptional regulator
J4N39_09270	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
J4N39_09275	COG0813	purine-nucleoside phosphorylase activity
J4N39_09280	COG0402	S-adenosylhomocysteine deaminase activity
J4N39_09315	COG3706	GGDEF domain
J4N39_09335	COG1196	nuclear chromosome segregation
J4N39_09355	COG2205	protein histidine kinase activity
J4N39_09355	COG0784	Response regulator, receiver
J4N39_09380	COG0583	DNA-binding transcription factor activity
J4N39_09385	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
J4N39_09390	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
J4N39_09395	COG2885	chlorophyll binding
J4N39_09400	COG0823	Involved in the tonB-independent uptake of proteins
J4N39_09415	COG0811	peptide transport
J4N39_09420	COG0824	Thioesterase
J4N39_09430	COG4890	Cyd operon protein YbgT
J4N39_09435	COG1294	oxidase, subunit
J4N39_09440	COG1271	oxidase subunit
J4N39_09445	COG2255	four-way junction helicase activity
J4N39_09450	COG0632	four-way junction helicase activity
J4N39_09455	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
J4N39_09475	COG1801	Protein of unknown function DUF72
J4N39_09480	COG4106	trans-aconitate 2-methyltransferase activity
J4N39_09485	COG0500	methyltransferase
J4N39_09490	COG0189	ligase activity
J4N39_09490	COG4067	protein conserved in archaea
J4N39_09505	COG1435	thymidine kinase activity
J4N39_09510	COG0215	cysteine-tRNA ligase activity
J4N39_09515	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
J4N39_09520	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
J4N39_09525	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
J4N39_09530	COG3012	SEC-C Motif Domain Protein
J4N39_09535	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
J4N39_09535	COG0140	phosphoribosyl-ATP diphosphatase activity
J4N39_09545	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
J4N39_09550	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
J4N39_09555	COG0131	Imidazoleglycerol-phosphate dehydratase
J4N39_09555	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
J4N39_09570	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
J4N39_09575	COG1757	Na H antiporter
J4N39_09585	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
J4N39_09595	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
J4N39_09600	COG1199	ATP-dependent helicase activity
J4N39_09605	COG0730	response to heat
J4N39_09625	COG2268	Band 7 protein
J4N39_09635	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
J4N39_09650	COG0300	oxidoreductase activity
J4N39_09675	COG2226	methyltransferase
J4N39_09680	COG0156	8-amino-7-oxononanoate synthase activity
J4N39_09685	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
J4N39_09700	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
J4N39_09705	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
J4N39_09720	COG0686	Belongs to the AlaDH PNT family
J4N39_09730	COG0583	DNA-binding transcription factor activity
J4N39_09745	COG2963	transposase activity
J4N39_09750	COG2801	Transposase and inactivated derivatives
J4N39_09755	COG0284	orotidine-5'-phosphate decarboxylase activity
J4N39_09760	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
J4N39_09765	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
J4N39_09775	COG0539	negative regulation of cytoplasmic translation
J4N39_09780	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
J4N39_09790	COG0616	signal peptide processing
J4N39_09795	COG1028	Short-chain dehydrogenase reductase Sdr
J4N39_09800	COG0784	Response regulator, receiver
J4N39_09800	COG0835	chemotaxis
J4N39_09805	COG1940	carbohydrate kinase activity
J4N39_09810	COG0469	pyruvate kinase activity
J4N39_09815	COG4667	esterase of the alpha-beta hydrolase superfamily
J4N39_09830	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
J4N39_09830	COG1263	PTS System
J4N39_09835	COG0084	hydrolase, TatD family'
J4N39_09845	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
J4N39_09850	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
J4N39_09855	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
J4N39_09880	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
J4N39_09885	COG0416	fatty acid biosynthetic process
J4N39_09890	COG0333	Belongs to the bacterial ribosomal protein bL32 family
J4N39_09900	COG0424	maF-like protein
J4N39_09905	COG0564	pseudouridine synthase activity
J4N39_09910	COG1530	ribonuclease E activity
J4N39_09915	COG0659	secondary active sulfate transmembrane transporter activity
J4N39_09920	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
J4N39_09925	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
J4N39_09940	COG2982	Protein involved in outer membrane biogenesis
J4N39_09945	COG0572	uridine kinase
J4N39_09950	COG0489	protein tyrosine kinase activity
J4N39_09965	COG2186	Transcriptional regulator
J4N39_09970	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
J4N39_09975	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
J4N39_09980	COG0653	protein targeting
J4N39_09985	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
J4N39_09995	COG0366	Alpha amylase catalytic
J4N39_10005	COG4120	Belongs to the binding-protein-dependent transport system permease family
J4N39_10015	COG3092	negative regulation of chromosome organization
J4N39_10020	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
J4N39_10025	COG0857	belongs to the CobB CobQ family
J4N39_10025	COG0280	phosphate acetyltransferase
J4N39_10040	COG1609	Transcriptional regulator
J4N39_10045	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
J4N39_10050	COG1879	ABC-type sugar transport system periplasmic component
J4N39_10055	COG1172	Belongs to the binding-protein-dependent transport system permease family
J4N39_10060	COG1129	ABC transporter
J4N39_10065	COG1869	D-ribose catabolic process
J4N39_10115	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
J4N39_10120	COG0596	Alpha beta hydrolase
J4N39_10125	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
J4N39_10130	COG1169	isochorismate synthase
J4N39_10135	COG0436	Aminotransferase
J4N39_10140	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
J4N39_10145	COG0232	Belongs to the dGTPase family. Type 2 subfamily
J4N39_10185	COG1596	polysaccharide export
J4N39_10185	COG1555	photosystem II stabilization
J4N39_10190	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
J4N39_10195	COG0776	regulation of translation
J4N39_10200	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
J4N39_10205	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
J4N39_10215	COG0544	peptidyl-prolyl cis-trans isomerase activity
J4N39_10225	COG2204	response regulator
J4N39_10245	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
J4N39_10250	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
J4N39_10255	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
J4N39_10260	COG3842	ATPase activity
J4N39_10265	COG0395	ABC-type sugar transport system, permease component
J4N39_10270	COG1175	transmembrane transport
J4N39_10275	COG1653	transport
J4N39_10295	COG0784	Response regulator, receiver
J4N39_10295	COG2205	protein histidine kinase activity
J4N39_10295	COG5002	protein histidine kinase activity
J4N39_10330	COG1073	alpha beta
J4N39_10330	COG2226	methyltransferase
J4N39_10340	COG1629	transport
J4N39_10340	COG4774	siderophore transport
J4N39_10345	COG1120	ATPase activity
J4N39_10350	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
J4N39_10355	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
J4N39_10360	COG4592	Periplasmic binding protein
J4N39_10370	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
J4N39_10370	COG2207	Transcriptional regulator
J4N39_10375	COG2375	cellular response to nickel ion
J4N39_10405	COG0328	RNA-DNA hybrid ribonuclease activity
J4N39_10425	COG2951	lytic endotransglycosylase activity
J4N39_10430	COG3100	YcgL domain-containing protein
J4N39_10440	COG2894	cell division
J4N39_10445	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
J4N39_10450	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
J4N39_10455	COG0318	PFAM AMP-dependent synthetase and ligase
J4N39_10460	COG2267	carboxylic ester hydrolase activity
J4N39_10475	COG1214	PFAM Peptidase M22, glycoprotease
J4N39_10480	COG1199	ATP-dependent helicase activity
J4N39_10490	COG0788	formyltetrahydrofolate deformylase activity
J4N39_10495	COG0840	transmembrane signaling receptor activity
J4N39_10510	COG3102	Protein conserved in bacteria
J4N39_10515	COG0018	arginyl-trna synthetase
J4N39_10520	COG1560	Kdo2-lipid A biosynthetic process
J4N39_10535	COG0745	RESPONSE REGULATOR receiver
J4N39_10535	COG2205	protein histidine kinase activity
J4N39_10535	COG3292	Two component regulator propeller
J4N39_10540	COG0739	heme binding
J4N39_10545	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
J4N39_10550	COG1121	(ABC) transporter
J4N39_10555	COG1108	ABC-type Mn2 Zn2 transport systems permease components
J4N39_10570	COG0508	dehydrogenase complex catalyzes the overall conversion of
J4N39_10575	COG0567	Dehydrogenase, E1 component
J4N39_10590	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
J4N39_10600	COG0372	Belongs to the citrate synthase family
J4N39_10605	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
J4N39_10615	COG0033	Phosphoglucomutase
J4N39_10620	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
J4N39_10625	COG0596	Alpha beta hydrolase
J4N39_10650	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
J4N39_10655	COG1263	PTS System
J4N39_10655	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
J4N39_10660	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
J4N39_10665	COG1846	Transcriptional regulator
J4N39_10665	COG1940	carbohydrate kinase activity
J4N39_10675	COG0367	asparagine synthase
J4N39_10685	COG3104	oligopeptide transport
J4N39_10690	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
J4N39_10700	COG0326	Molecular chaperone. Has ATPase activity
J4N39_10705	COG3710	Transcriptional regulator
J4N39_10725	COG0622	Phosphoesterase
J4N39_10750	COG1090	epimerase
J4N39_10755	COG0300	oxidoreductase activity
J4N39_10760	COG3118	belongs to the thioredoxin family
J4N39_10765	COG0330	HflC and HflK could
J4N39_10775	COG0789	Transcriptional regulator
J4N39_10795	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
J4N39_10800	COG3115	cell septum assembly
J4N39_10805	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
J4N39_10815	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
J4N39_10825	COG2190	(PTS) system
J4N39_10840	COG3646	Phage regulatory protein
J4N39_10850	COG3335	DDE superfamily endonuclease
J4N39_10875	COG3951	Flagellar rod assembly protein muramidase FlgJ
J4N39_10875	COG1705	Flagellar rod assembly protein muramidase FlgJ
J4N39_10880	COG1706	bacterial-type flagellum-dependent cell motility
J4N39_10885	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
J4N39_10895	COG4787	bacterial-type flagellum-dependent cell motility
J4N39_10900	COG1749	Flagellar hook protein flgE
J4N39_10910	COG1558	bacterial-type flagellum-dependent cell motility
J4N39_10915	COG1815	bacterial-type flagellum-dependent cell motility
J4N39_10920	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
J4N39_10925	COG0784	Response regulator, receiver
J4N39_10925	COG0835	chemotaxis
J4N39_10970	COG3706	GGDEF domain
J4N39_10990	COG0444	Belongs to the ABC transporter superfamily
J4N39_10995	COG4608	Belongs to the ABC transporter superfamily
J4N39_11010	COG2217	Heavy metal translocating P-type atpase
J4N39_11010	COG2608	mercury ion transmembrane transporter activity
J4N39_11035	COG2840	Smr protein MutS2
J4N39_11050	COG2067	long-chain fatty acid transport protein
J4N39_11055	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
J4N39_11070	COG2877	3-deoxy-8-phosphooctulonate synthase activity
J4N39_11075	COG2912	Transglutaminase-like superfamily
J4N39_11085	COG2890	protein-(glutamine-N5) methyltransferase activity
J4N39_11090	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
J4N39_11100	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
J4N39_11105	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
J4N39_11110	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
J4N39_11115	COG1757	Na H antiporter
J4N39_11120	COG0193	aminoacyl-tRNA hydrolase activity
J4N39_11230	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
J4N39_11235	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
J4N39_11240	COG1702	phosphate starvation-inducible protein PhoH
J4N39_11250	COG4535	Mg2 and Co2 transporter CorC
J4N39_11260	COG2888	peptidyl-tyrosine sulfation
J4N39_11265	COG0495	leucyl-tRNA aminoacylation
J4N39_11270	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
J4N39_11275	COG1466	dna polymerase III delta subunit
J4N39_11280	COG0799	negative regulation of ribosome biogenesis
J4N39_11285	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
J4N39_11290	COG0768	penicillin binding
J4N39_11295	COG0772	Belongs to the SEDS family
J4N39_11300	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
J4N39_11305	COG1686	Belongs to the peptidase S11 family
J4N39_11310	COG2921	Belongs to the UPF0250 family
J4N39_11320	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
J4N39_11340	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
J4N39_11350	COG0366	Alpha amylase catalytic
J4N39_11355	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
J4N39_11355	COG1263	PTS System
J4N39_11360	COG1609	Transcriptional regulator
J4N39_11370	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
J4N39_11375	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
J4N39_11380	COG2011	ABC-type metal ion transport system permease component
J4N39_11385	COG1464	Belongs to the NlpA lipoprotein family
J4N39_11395	COG0402	S-adenosylhomocysteine deaminase activity
J4N39_11400	COG1522	sequence-specific DNA binding
J4N39_11410	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
J4N39_11420	COG0254	rRNA binding
J4N39_11425	COG1720	tRNA m6t6A37 methyltransferase activity
J4N39_11430	COG0442	prolyl-tRNA aminoacylation
J4N39_11450	COG0733	neurotransmitter:sodium symporter activity
J4N39_11460	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
J4N39_11465	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
J4N39_11480	COG1477	protein flavinylation
J4N39_11490	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
J4N39_11510	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
J4N39_11515	COG0271	Belongs to the BolA IbaG family
J4N39_11535	COG2211	Major facilitator Superfamily
J4N39_11545	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
J4N39_11550	COG0693	protein deglycase activity
J4N39_11555	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
J4N39_11560	COG2166	iron-sulfur cluster assembly
J4N39_11565	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
J4N39_11570	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
J4N39_11580	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
J4N39_11580	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
J4N39_11590	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
J4N39_11595	COG1074	ATP-dependent DNA helicase activity
J4N39_11600	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
J4N39_11605	COG0583	DNA-binding transcription factor activity
J4N39_11610	COG1671	Belongs to the UPF0178 family
J4N39_11615	COG3141	response to X-ray
J4N39_11620	COG2171	N-acyltransferase activity
J4N39_11635	COG0583	DNA-binding transcription factor activity
J4N39_11645	COG0784	Response regulator, receiver
J4N39_11645	COG3437	response regulator, receiver
J4N39_11700	COG4964	Belongs to the GSP D family
J4N39_11720	COG1022	Amp-dependent synthetase and ligase
J4N39_11730	COG0583	DNA-binding transcription factor activity
J4N39_11735	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
J4N39_11745	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
J4N39_11755	COG0560	Phosphoserine phosphatase
J4N39_11765	COG0813	purine-nucleoside phosphorylase activity
J4N39_11775	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
J4N39_11780	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
J4N39_11790	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
J4N39_11795	COG0084	hydrolase, TatD family'
J4N39_11800	COG1744	ABC transporter substrate-binding protein PnrA-like
J4N39_11805	COG3845	ABC transporter
J4N39_11810	COG4603	Belongs to the binding-protein-dependent transport system permease family
J4N39_11815	COG1079	Belongs to the binding-protein-dependent transport system permease family
J4N39_11835	COG3153	acetyltransferase
J4N39_11840	COG3154	lipid carrier protein
J4N39_11850	COG0826	peptidase U32
J4N39_11855	COG0826	peptidase U32
J4N39_11875	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
J4N39_11885	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
J4N39_11890	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
J4N39_11895	COG0195	Participates in both transcription termination and antitermination
J4N39_11900	COG0779	Required for maturation of 30S ribosomal subunits
J4N39_11915	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
J4N39_11925	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
J4N39_11930	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
J4N39_11935	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
J4N39_11940	COG1534	Rna-binding protein
J4N39_11945	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
J4N39_11950	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
J4N39_11955	COG2027	D-alanyl-D-alanine carboxypeptidase
J4N39_11965	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
J4N39_11970	COG0739	heme binding
J4N39_11990	COG0316	Belongs to the HesB IscA family
J4N39_12000	COG0628	permease
J4N39_12010	COG0784	Response regulator, receiver
J4N39_12010	COG2205	protein histidine kinase activity
J4N39_12015	COG0747	negative chemotaxis
J4N39_12025	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
J4N39_12030	COG0444	Belongs to the ABC transporter superfamily
J4N39_12035	COG4608	Belongs to the ABC transporter superfamily
J4N39_12045	COG2971	BadF BadG BcrA BcrD
J4N39_12060	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
J4N39_12065	COG3842	ATPase activity
J4N39_12075	COG1840	ABC-type Fe3 transport system, periplasmic component
J4N39_12080	COG0004	ammonium transporteR
J4N39_12090	COG3112	Uncharacterised protein family (UPF0231)
J4N39_12100	COG1752	Esterase of the alpha-beta hydrolase superfamily
J4N39_12105	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
J4N39_12110	COG1643	Atp-dependent helicase
J4N39_12115	COG1489	DNA binding
J4N39_12120	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
J4N39_12125	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
J4N39_12135	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
J4N39_12140	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
J4N39_12155	COG0739	heme binding
J4N39_12160	COG1605	Chorismate mutase
J4N39_12160	COG0287	Prephenate dehydrogenase
J4N39_12165	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
J4N39_12170	COG3275	phosphorelay sensor kinase activity
J4N39_12175	COG3279	Response regulator of the LytR AlgR family
J4N39_12180	COG1966	Carbon starvation protein
J4N39_12195	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
J4N39_12210	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
J4N39_12215	COG1047	Peptidyl-prolyl cis-trans
J4N39_12225	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
J4N39_12230	COG0196	riboflavin kinase activity
J4N39_12235	COG0728	peptidoglycan biosynthetic process
J4N39_12240	COG0268	Binds directly to 16S ribosomal RNA
J4N39_12245	COG0842	Transport permease protein
J4N39_12250	COG1131	(ABC) transporter
J4N39_12255	COG0659	secondary active sulfate transmembrane transporter activity
J4N39_12260	COG0288	reversible hydration of carbon dioxide
J4N39_12280	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
J4N39_12285	COG0508	dehydrogenase complex catalyzes the overall conversion of
J4N39_12290	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
J4N39_12295	COG2186	Transcriptional regulator
J4N39_12305	COG0157	Belongs to the NadC ModD family
J4N39_12315	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
J4N39_12320	COG1459	type II secretion system
J4N39_12330	COG0237	dephospho-CoA kinase activity
J4N39_12335	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
J4N39_12340	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
J4N39_12350	COG0653	protein targeting
J4N39_12355	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
J4N39_12360	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
J4N39_12365	COG0849	cell division
J4N39_12370	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
J4N39_12380	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
J4N39_12385	COG0772	Belongs to the SEDS family
J4N39_12395	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
J4N39_12400	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
J4N39_12405	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
J4N39_12410	COG0768	penicillin binding
J4N39_12415	COG3116	cell division
J4N39_12420	COG0275	rRNA processing
J4N39_12430	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
J4N39_12435	COG3107	peptidoglycan biosynthetic process
J4N39_12440	COG0792	nuclease activity
J4N39_12445	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
J4N39_12450	COG2823	Periplasmic or secreted lipoprotein
J4N39_12455	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
J4N39_12465	COG0730	response to heat
J4N39_12475	COG0494	nUDIX hydrolase
J4N39_12490	COG0667	Aldo Keto reductase
J4N39_12500	COG2204	response regulator
J4N39_12505	COG2969	positive regulation of protein catabolic process
J4N39_12510	COG0625	glutathione transferase activity
J4N39_12515	COG2857	Cytochrome c1
J4N39_12520	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
J4N39_12525	COG0723	plastoquinol--plastocyanin reductase activity
J4N39_12530	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
J4N39_12540	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
J4N39_12550	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
J4N39_12555	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
J4N39_12560	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
J4N39_12570	COG3150	esterase
J4N39_12580	COG3151	Protein conserved in bacteria
J4N39_12585	COG0494	nUDIX hydrolase
J4N39_12590	COG1538	Outer membrane efflux protein
J4N39_12600	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
J4N39_12600	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
J4N39_12605	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
J4N39_12625	COG3025	triphosphatase activity
J4N39_12630	COG1392	Phosphate transport regulator
J4N39_12635	COG0306	phosphate transporter
J4N39_12640	COG4991	sh3 domain protein
J4N39_12650	COG3267	Type II secretory pathway component ExeA
J4N39_12650	COG3409	Peptidoglycan-binding domain 1 protein
J4N39_12665	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
J4N39_12670	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
J4N39_12675	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
J4N39_12685	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
J4N39_12690	COG0828	Belongs to the bacterial ribosomal protein bS21 family
J4N39_12695	COG1610	YqeY-like protein
J4N39_12700	COG0358	DNA primase activity
J4N39_12705	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
J4N39_12725	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
J4N39_12735	COG2855	membrane
J4N39_12750	COG0363	glucosamine-6-phosphate deaminase activity
J4N39_12755	COG0469	pyruvate kinase activity
J4N39_12765	COG3706	GGDEF domain
J4N39_12775	COG0028	Belongs to the TPP enzyme family
J4N39_12780	COG1022	Amp-dependent synthetase and ligase
J4N39_12785	COG0583	DNA-binding transcription factor activity
J4N39_12795	COG0671	phosphoesterase, PA-phosphatase related
J4N39_12815	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
J4N39_12820	COG0473	3-isopropylmalate dehydrogenase activity
J4N39_12830	COG0066	3-isopropylmalate dehydratase activity
J4N39_12845	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
J4N39_12850	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
J4N39_12855	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
J4N39_12860	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
J4N39_12865	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
J4N39_12870	COG2967	ApaG domain
J4N39_12885	COG3610	response to peptide
J4N39_12890	COG2966	Psort location CytoplasmicMembrane, score
J4N39_12895	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
J4N39_12900	COG0211	Belongs to the bacterial ribosomal protein bL27 family
J4N39_12905	COG0261	This protein binds to 23S rRNA in the presence of protein L20
J4N39_12910	COG0142	geranyltranstransferase activity
J4N39_12915	COG3706	GGDEF domain
J4N39_12920	COG0039	L-malate dehydrogenase activity
J4N39_12925	COG1438	arginine binding
J4N39_12930	COG2358	TRAP transporter, solute receptor (TAXI family
J4N39_12945	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
J4N39_12960	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
J4N39_12965	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
J4N39_12970	COG1178	ABC-type Fe3 transport system permease component
J4N39_12975	COG4143	(ABC) transporter
J4N39_12980	COG0163	prenyltransferase activity
J4N39_12985	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
J4N39_12990	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
J4N39_12995	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
J4N39_13000	COG2105	PFAM AIG2 family protein
J4N39_13010	COG0729	surface antigen
J4N39_13015	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
J4N39_13025	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
J4N39_13030	COG0251	oxidation-reduction process
J4N39_13035	COG0204	Acyl-transferase
J4N39_13045	COG5007	Belongs to the BolA IbaG family
J4N39_13055	COG2854	intermembrane phospholipid transfer
J4N39_13065	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
J4N39_13070	COG1127	ABC transporter
J4N39_13080	COG0517	IMP dehydrogenase activity
J4N39_13080	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
J4N39_13085	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
J4N39_13095	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
J4N39_13100	COG1137	ATPase activity
J4N39_13110	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
J4N39_13115	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
J4N39_13120	COG1660	Displays ATPase and GTPase activities
J4N39_13125	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
J4N39_13130	COG2239	Acts as a magnesium transporter
J4N39_13135	COG0312	modulator of DNA gyrase
J4N39_13145	COG0312	modulator of DNA gyrase
J4N39_13150	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
J4N39_13165	COG0424	maF-like protein
J4N39_13170	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
J4N39_13175	COG1792	Involved in formation and maintenance of cell shape
J4N39_13180	COG1077	Cell shape determining protein MreB Mrl
J4N39_13220	COG2165	general secretion pathway protein
J4N39_13230	COG1459	type II secretion system
J4N39_13235	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
J4N39_13245	COG3267	Type II secretory pathway component ExeA
J4N39_13245	COG3409	Peptidoglycan-binding domain 1 protein
J4N39_13270	COG2199	diguanylate cyclase activity
J4N39_13270	COG2200	EAL domain
J4N39_13275	COG0629	single-stranded DNA binding
J4N39_13295	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
J4N39_13305	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
J4N39_13310	COG0527	aspartate kinase activity
J4N39_13315	COG1410	methionine synthase
J4N39_13315	COG0646	methionine synthase
J4N39_13320	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
J4N39_13365	COG0175	sulfate reduction
J4N39_13370	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
J4N39_13375	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
J4N39_13400	COG0735	belongs to the Fur family
J4N39_13425	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
J4N39_13440	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
J4N39_13445	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
J4N39_13450	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
J4N39_13475	COG1612	heme a metabolic process
J4N39_13480	COG0109	protoheme IX farnesyltransferase activity
J4N39_13500	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
J4N39_13505	COG0557	exoribonuclease II activity
J4N39_13515	COG1017	nitric oxide dioxygenase activity
J4N39_13515	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
J4N39_13520	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
J4N39_13525	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
J4N39_13535	COG0330	HflC and HflK could
J4N39_13540	COG0330	HflC and HflK could
J4N39_13545	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
J4N39_13560	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
J4N39_13570	COG0802	atpase or kinase
J4N39_13575	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
J4N39_13630	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
J4N39_13635	COG1162	GTPase activity
J4N39_13640	COG0688	phosphatidylethanolamine metabolic process
J4N39_13645	COG0471	metal ion transport
J4N39_13655	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
J4N39_13660	COG1053	succinate dehydrogenase
J4N39_13665	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
J4N39_13670	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
J4N39_13685	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
J4N39_13690	COG1509	lysine 2,3-aminomutase activity
J4N39_13710	COG0459	protein refolding
J4N39_13720	COG0534	Mate efflux family protein
J4N39_13725	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
J4N39_13735	COG1045	serine acetyltransferase
J4N39_13740	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
J4N39_13750	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
J4N39_13755	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
J4N39_13760	COG4942	peptidase
J4N39_13765	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
J4N39_13770	COG5433	transposase activity
J4N39_13780	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
J4N39_13865	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
J4N39_13875	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
J4N39_13875	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
J4N39_13880	COG0367	asparagine synthase
J4N39_13890	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
J4N39_13940	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
J4N39_13965	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
J4N39_13980	COG0859	PFAM glycosyl transferase family 9
J4N39_13985	COG1519	Transferase
J4N39_13990	COG0859	PFAM glycosyl transferase family 9
J4N39_13995	COG0463	Glycosyl transferase, family 2
J4N39_14000	COG0859	PFAM glycosyl transferase family 9
J4N39_14005	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
J4N39_14010	COG1368	sulfuric ester hydrolase activity
J4N39_14025	COG0267	Belongs to the bacterial ribosomal protein bL33 family
J4N39_14030	COG0227	Belongs to the bacterial ribosomal protein bL28 family
J4N39_14040	COG2003	Belongs to the UPF0758 family
J4N39_14045	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
J4N39_14050	COG1309	transcriptional regulator
J4N39_14060	COG1560	Kdo2-lipid A biosynthetic process
J4N39_14080	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
J4N39_14085	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
J4N39_14090	COG1561	YicC-like family, N-terminal region
J4N39_14105	COG0194	GDP metabolic process
J4N39_14110	COG1758	RNA polymerase activity
J4N39_14115	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
J4N39_14120	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
J4N39_14125	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
J4N39_14140	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
J4N39_14150	COG2183	response to ionizing radiation
J4N39_14155	COG0438	transferase activity, transferring glycosyl groups
J4N39_14160	COG3642	lipopolysaccharide core region biosynthetic process
J4N39_14170	COG0596	Alpha beta hydrolase
J4N39_14175	COG1040	competence protein
J4N39_14185	COG1218	3'(2'),5'-bisphosphate nucleotidase
J4N39_14190	COG0494	nUDIX hydrolase
J4N39_14200	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
J4N39_14205	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
J4N39_14210	COG3156	type II secretion system protein K
J4N39_14215	COG4795	General secretion pathway protein
J4N39_14220	COG2165	general secretion pathway protein
J4N39_14225	COG2165	general secretion pathway protein
J4N39_14230	COG2165	general secretion pathway protein
J4N39_14235	COG1459	type II secretion system
J4N39_14240	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
J4N39_14250	COG3031	protein transport across the cell outer membrane
J4N39_14255	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
J4N39_14260	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
J4N39_14265	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
J4N39_14275	COG0456	acetyltransferase
J4N39_14280	COG1490	D-aminoacyl-tRNA deacylase activity
J4N39_14285	COG1295	ribonuclease BN
J4N39_14300	COG1217	gtp-binding protein TYPA
J4N39_14305	COG0174	glutamine synthetase
J4N39_14315	COG3852	Histidine kinase
J4N39_14320	COG2204	response regulator
J4N39_14330	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
J4N39_14360	COG0218	Necessary for normal cell division and for the maintenance of normal septation
J4N39_14365	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
J4N39_14365	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
J4N39_14380	COG0084	hydrolase, TatD family'
J4N39_14385	COG0805	protein transport
J4N39_14390	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
J4N39_14400	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
J4N39_14405	COG3165	ubiquinone biosynthetic process from chorismate
J4N39_14410	COG2226	methyltransferase
J4N39_14415	COG1322	Protein conserved in bacteria
J4N39_14425	COG2081	HI0933 family
J4N39_14435	COG1528	Iron-storage protein
J4N39_14440	COG0589	response to stress
J4N39_14450	COG0742	ribosomal rna small subunit methyltransferase
J4N39_14455	COG1522	sequence-specific DNA binding
J4N39_14460	COG0339	signal peptide processing
J4N39_14465	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
J4N39_14470	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
J4N39_14485	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
J4N39_14490	COG0601	transmembrane transport
J4N39_14495	COG0747	negative chemotaxis
J4N39_14545	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
J4N39_14550	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
J4N39_14555	COG2960	long-chain fatty acid transporting porin activity
J4N39_14570	COG3710	Transcriptional regulator
J4N39_14580	COG5002	protein histidine kinase activity
J4N39_14580	COG0784	Response regulator, receiver
J4N39_14580	COG2205	protein histidine kinase activity
J4N39_14585	COG0210	DNA helicase
J4N39_14605	COG2259	Doxx family
J4N39_14625	COG0006	proline dipeptidase activity
J4N39_14630	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
J4N39_14635	COG2022	thiamine diphosphate biosynthetic process
J4N39_14640	COG2104	thiamine diphosphate biosynthetic process
J4N39_14645	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
J4N39_14650	COG0352	thiamine-phosphate diphosphorylase activity
J4N39_14655	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
J4N39_14660	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
J4N39_14720	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
J4N39_14725	COG1739	Uncharacterized protein family UPF0029
J4N39_14730	COG1024	Enoyl-CoA hydratase
J4N39_14730	COG1250	3-hydroxyacyl-CoA dehydrogenase
J4N39_14735	COG0183	Belongs to the thiolase family
J4N39_14740	COG0604	alcohol dehydrogenase
J4N39_14765	COG2119	membrane
J4N39_14770	COG0752	glycyl-tRNA synthetase alpha subunit
J4N39_14775	COG0751	glycine-tRNA ligase activity
J4N39_14780	COG0366	Alpha amylase catalytic
J4N39_14785	COG3977	Valine--pyruvate aminotransferase
J4N39_14790	COG2194	sulfuric ester hydrolase activity
J4N39_14795	COG0071	Belongs to the small heat shock protein (HSP20) family
J4N39_14805	COG0355	proton-transporting ATP synthase activity, rotational mechanism
J4N39_14810	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
J4N39_14815	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
J4N39_14820	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
J4N39_14825	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
J4N39_14830	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
J4N39_14840	COG0356	it plays a direct role in the translocation of protons across the membrane
J4N39_14845	COG3312	ion transport
J4N39_14850	COG1475	DNA binding
J4N39_14855	COG1192	Involved in chromosome partitioning
J4N39_14860	COG0357	Ribosomal RNA small subunit methyltransferase G
J4N39_14865	COG0445	tRNA wobble uridine modification
J4N39_14870	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
J4N39_14880	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
J4N39_14900	COG0230	Belongs to the bacterial ribosomal protein bL34 family
J4N39_14935	COG0217	transcriptional regulatory protein
J4N39_14940	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
J4N39_14965	COG2815	serine threonine protein kinase
J4N39_14965	COG0515	serine threonine protein kinase
J4N39_15000	COG0631	protein serine/threonine phosphatase activity
J4N39_15065	COG1116	anion transmembrane transporter activity
J4N39_15065	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
J4N39_15075	COG1116	anion transmembrane transporter activity
J4N39_15085	COG0840	transmembrane signaling receptor activity
J4N39_15090	COG3706	GGDEF domain
J4N39_15095	COG2814	Major facilitator Superfamily
J4N39_15100	COG0583	DNA-binding transcription factor activity
J4N39_15105	COG1335	isochorismatase
J4N39_15125	COG2315	Protein conserved in bacteria
J4N39_15170	COG1132	(ABC) transporter
J4N39_15190	COG1733	regulation of RNA biosynthetic process
J4N39_15230	COG0604	alcohol dehydrogenase
J4N39_15230	COG1028	Short-chain dehydrogenase reductase Sdr
J4N39_15230	COG3321	synthase
J4N39_15245	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
J4N39_15260	COG2205	protein histidine kinase activity
J4N39_15260	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
J4N39_15265	COG0243	molybdopterin cofactor binding
J4N39_15270	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
J4N39_15270	COG1648	precorrin-2 dehydrogenase activity
J4N39_15275	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
J4N39_15285	COG2223	nitrite transmembrane transporter activity
J4N39_15290	COG0515	serine threonine protein kinase
J4N39_15290	COG2815	serine threonine protein kinase
J4N39_15295	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
J4N39_15295	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
J4N39_15310	COG0346	lactoylglutathione lyase activity
J4N39_15320	COG0069	glutamate synthase activity
J4N39_15320	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
J4N39_15325	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
J4N39_15345	COG1028	Short-chain dehydrogenase reductase Sdr
J4N39_15350	COG1263	PTS System
J4N39_15350	COG2190	(PTS) system
J4N39_15350	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
J4N39_15365	COG2706	6-phosphogluconolactonase activity
J4N39_15375	COG3243	poly(R)-hydroxyalkanoic acid synthase
J4N39_15385	COG1309	transcriptional regulator
J4N39_15390	COG2130	NADP-dependent
J4N39_15395	COG1619	proteins homologs of microcin C7 resistance protein MccF
J4N39_15400	COG0366	Alpha amylase catalytic
J4N39_15420	COG0167	dihydroorotate dehydrogenase activity
J4N39_15420	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
J4N39_15430	COG0513	Belongs to the DEAD box helicase family
J4N39_15435	COG2873	o-acetylhomoserine
J4N39_15440	COG1522	sequence-specific DNA binding
J4N39_15445	COG0840	transmembrane signaling receptor activity
J4N39_15455	COG1280	lysine exporter protein (LysE YggA)
J4N39_15480	COG3085	chromosome segregation
J4N39_15485	COG0583	DNA-binding transcription factor activity
J4N39_15505	COG4989	oxidoreductase activity
J4N39_15515	COG3604	Transcriptional regulator
J4N39_15525	COG1309	transcriptional regulator
J4N39_15540	COG4335	DNA alkylation repair
J4N39_15545	COG1151	hydroxylamine reductase activity
J4N39_15550	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
J4N39_15575	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
J4N39_15585	COG2116	formate transmembrane transporter activity
J4N39_15595	COG1120	ATPase activity
J4N39_15600	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
J4N39_15605	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
J4N39_15610	COG4774	siderophore transport
J4N39_15630	COG1120	ATPase activity
J4N39_15650	COG4264	IucA IucC family
J4N39_15660	COG0513	Belongs to the DEAD box helicase family
J4N39_15675	COG4580	involved in the transport of maltose and maltodextrins
J4N39_15690	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
J4N39_15695	COG0784	Response regulator, receiver
J4N39_15695	COG5002	protein histidine kinase activity
J4N39_15695	COG2205	protein histidine kinase activity
J4N39_15715	COG0463	Glycosyl transferase, family 2
J4N39_15720	COG2814	Major facilitator Superfamily
J4N39_15730	COG1349	DNA-binding transcription factor activity
J4N39_15735	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
J4N39_15755	COG0058	SHG alpha-glucan phosphorylase activity
J4N39_15760	COG1640	4-alpha-glucanotransferase
J4N39_15765	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
J4N39_15775	COG0840	transmembrane signaling receptor activity
J4N39_15785	COG2133	pyrroloquinoline quinone binding
J4N39_15800	COG0534	Mate efflux family protein
J4N39_15830	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
J4N39_15835	COG2205	protein histidine kinase activity
J4N39_15835	COG0784	Response regulator, receiver
J4N39_15835	COG5002	protein histidine kinase activity
J4N39_15840	COG0745	RESPONSE REGULATOR receiver
J4N39_15845	COG2501	S4 domain
J4N39_15850	COG0366	Alpha amylase catalytic
J4N39_15855	COG0840	transmembrane signaling receptor activity
J4N39_15860	COG3706	GGDEF domain
J4N39_15865	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
J4N39_15875	COG0456	acetyltransferase
J4N39_15880	COG3706	GGDEF domain
J4N39_15890	COG1162	GTPase activity
J4N39_15915	COG2814	Major facilitator Superfamily
J4N39_15925	COG5001	Diguanylate cyclase
J4N39_15930	COG4172	Belongs to the ABC transporter superfamily
J4N39_15935	COG4239	(ABC) transporter, permease
J4N39_15940	COG4174	ABC transporter (Permease)
J4N39_15945	COG4166	transmembrane transport
J4N39_15955	COG3383	formate dehydrogenase (NAD+) activity
J4N39_15980	COG3507	Belongs to the glycosyl hydrolase 43 family
J4N39_15985	COG4213	ABC transporter substrate-binding protein
J4N39_15990	COG1129	ABC transporter
J4N39_15995	COG4214	carbohydrate transport
J4N39_16005	COG2115	Belongs to the xylose isomerase family
J4N39_16010	COG2207	Transcriptional regulator
J4N39_16010	COG1609	Transcriptional regulator
J4N39_16015	COG1070	Carbohydrate kinase
J4N39_16035	COG2188	Transcriptional regulator
J4N39_16065	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
J4N39_16075	COG0488	(ABC) transporter
J4N39_16085	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
J4N39_16090	COG4804	nuclease activity
J4N39_16095	COG0732	type I restriction modification DNA specificity domain
J4N39_16105	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
J4N39_16110	COG3852	Histidine kinase
J4N39_16120	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
J4N39_16125	COG1882	Formate acetyltransferase
J4N39_16135	COG2376	Dihydroxyacetone kinase
J4N39_16140	COG1461	Dihydroxyacetone kinase
J4N39_16145	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
J4N39_16165	COG3284	Transcriptional regulator
J4N39_16170	COG1349	DNA-binding transcription factor activity
J4N39_16175	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
J4N39_16200	COG5001	Diguanylate cyclase
J4N39_16205	COG0191	fructose-bisphosphate aldolase activity
J4N39_16215	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
J4N39_16220	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
J4N39_16225	COG1501	Belongs to the glycosyl hydrolase 31 family
J4N39_16255	COG1454	alcohol dehydrogenase
J4N39_16285	COG3634	alkyl hydroperoxide reductase activity
J4N39_16340	COG4964	Belongs to the GSP D family
J4N39_16350	COG0455	bacterial-type flagellum organization
J4N39_16375	COG2885	chlorophyll binding
J4N39_16385	COG0786	glutamate:sodium symporter activity
J4N39_16450	COG1765	OsmC-like protein
J4N39_16470	COG0745	RESPONSE REGULATOR receiver
J4N39_16475	COG2205	protein histidine kinase activity
J4N39_16480	COG0625	glutathione transferase activity
J4N39_16485	COG0251	oxidation-reduction process
J4N39_16495	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
J4N39_16500	COG1215	transferase activity, transferring glycosyl groups
J4N39_16505	COG0438	transferase activity, transferring glycosyl groups
J4N39_16550	COG2204	response regulator
J4N39_16555	COG3437	response regulator, receiver
J4N39_16555	COG3850	Histidine kinase
J4N39_16555	COG4999	Histidine kinase
J4N39_16555	COG2205	protein histidine kinase activity
J4N39_16590	COG1228	amidohydrolase
J4N39_16605	COG0626	cystathionine gamma-synthase activity
J4N39_16615	COG0456	acetyltransferase
J4N39_16630	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
J4N39_16635	COG0573	inorganic phosphate transmembrane transporter activity
J4N39_16640	COG0581	inorganic phosphate transmembrane transporter activity
J4N39_16645	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
J4N39_16660	COG0583	DNA-binding transcription factor activity
J4N39_16665	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
J4N39_16670	COG0673	inositol 2-dehydrogenase activity
J4N39_16685	COG0840	transmembrane signaling receptor activity
J4N39_16695	COG1609	Transcriptional regulator
J4N39_16710	COG0826	peptidase U32
J4N39_16720	COG2186	Transcriptional regulator
J4N39_16730	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
J4N39_16740	COG0246	Mannitol dehydrogenase
J4N39_16745	COG1904	glucuronate isomerase
J4N39_16750	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
J4N39_16755	COG0800	Aldolase
J4N39_16770	COG0534	Mate efflux family protein
J4N39_16785	COG0583	DNA-binding transcription factor activity
J4N39_16815	COG3250	beta-galactosidase activity
J4N39_16830	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
J4N39_16835	COG0574	Belongs to the PEP-utilizing enzyme family
J4N39_16835	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
J4N39_16840	COG2801	Transposase and inactivated derivatives
J4N39_16845	COG2963	transposase activity
J4N39_16850	COG2200	EAL domain
J4N39_16890	COG0653	protein targeting
J4N39_16920	COG0384	phenazine biosynthesis protein PhzF
J4N39_16940	COG4628	conserved protein (DUF2132)
J4N39_16945	COG0513	Belongs to the DEAD box helicase family
J4N39_16960	COG1011	Hydrolase
J4N39_16975	COG0840	transmembrane signaling receptor activity
J4N39_16980	COG2964	Protein conserved in bacteria
J4N39_16990	COG0251	oxidation-reduction process
J4N39_17010	COG2195	Cleaves the N-terminal amino acid of tripeptides
J4N39_17015	COG2964	Protein conserved in bacteria
J4N39_17025	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
J4N39_17040	COG2176	DNA-directed DNA polymerase activity
J4N39_17045	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
J4N39_17050	COG0523	cobalamin synthesis protein
J4N39_17095	COG1609	Transcriptional regulator
J4N39_17100	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
J4N39_17105	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
J4N39_17135	COG0561	phosphatase activity
J4N39_17155	COG0813	purine-nucleoside phosphorylase activity
J4N39_17165	COG0789	Transcriptional regulator
J4N39_17170	COG0415	Belongs to the DNA photolyase family
J4N39_17175	COG1388	LysM domain
J4N39_17175	COG1376	ErfK ybiS ycfS ynhG family protein
J4N39_17185	COG0513	Belongs to the DEAD box helicase family
J4N39_17210	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
J4N39_17225	COG0583	DNA-binding transcription factor activity
J4N39_17245	COG0121	glutamine amidotransferase
J4N39_17260	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
J4N39_17275	COG0840	transmembrane signaling receptor activity
J4N39_17315	COG2801	Transposase and inactivated derivatives
J4N39_17320	COG2963	transposase activity
J4N39_17325	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
J4N39_17340	COG3706	GGDEF domain
J4N39_17345	COG1263	PTS System
J4N39_17345	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
J4N39_17350	COG1609	Transcriptional regulator
J4N39_17355	COG1621	beta-fructofuranosidase activity
J4N39_17360	COG0673	inositol 2-dehydrogenase activity
J4N39_17365	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
J4N39_17370	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
J4N39_17380	COG0583	DNA-binding transcription factor activity
J4N39_17390	COG2897	thiosulfate sulfurtransferase activity
J4N39_17400	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
J4N39_17405	COG0303	'Molybdopterin
J4N39_17435	COG1742	UPF0060 membrane protein
J4N39_17445	COG2759	Belongs to the formate--tetrahydrofolate ligase family
J4N39_17450	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
J4N39_17485	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
J4N39_17510	COG2249	NAD(P)H dehydrogenase (quinone) activity
J4N39_17520	COG1119	ATPase activity
J4N39_17525	COG0402	S-adenosylhomocysteine deaminase activity
J4N39_17530	COG0564	pseudouridine synthase activity
J4N39_17535	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
J4N39_17540	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
J4N39_17560	COG1566	PFAM secretion protein HlyD family protein
J4N39_17570	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
J4N39_17600	COG2926	Belongs to the UPF0265 family
J4N39_17610	COG3132	Protein of unknown function, DUF480
J4N39_17615	COG2827	Endonuclease containing a URI domain
J4N39_17620	COG5001	Diguanylate cyclase
J4N39_17630	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
J4N39_17650	COG2814	Major facilitator Superfamily
J4N39_17665	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
J4N39_17670	COG2199	diguanylate cyclase activity
J4N39_17670	COG2203	Gaf domain
J4N39_17680	COG3005	denitrification pathway
J4N39_17685	COG3043	anaerobic respiration
J4N39_17690	COG0348	domain, Protein
J4N39_17695	COG0437	4 iron, 4 sulfur cluster binding
J4N39_17705	COG3062	negative regulation of establishment of protein localization
J4N39_17715	COG3850	Histidine kinase
J4N39_17720	COG2197	response regulator
J4N39_17725	COG1879	ABC-type sugar transport system periplasmic component
J4N39_17785	COG0583	DNA-binding transcription factor activity
J4N39_17790	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
J4N39_17805	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
J4N39_17820	COG0189	ligase activity
J4N39_17830	COG4067	protein conserved in archaea
J4N39_17830	COG0189	ligase activity
J4N39_17835	COG0039	L-malate dehydrogenase activity
J4N39_17840	COG0277	FAD linked oxidase domain protein
J4N39_17845	COG0583	DNA-binding transcription factor activity
J4N39_17865	COG2267	carboxylic ester hydrolase activity
J4N39_17880	COG0702	epimerase
J4N39_17885	COG1283	sodium-dependent phosphate transmembrane transporter activity
J4N39_17905	COG0697	spore germination
J4N39_17955	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
J4N39_17955	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
J4N39_17960	COG0509	glycine decarboxylation via glycine cleavage system
J4N39_18010	COG3706	GGDEF domain
J4N39_18020	COG2207	Transcriptional regulator
J4N39_18025	COG0418	dihydroorotase activity
J4N39_18030	COG3217	Mosc domain protein beta barrel domain protein
J4N39_18030	COG0633	Ferredoxin
J4N39_18030	COG0633	Ferredoxin
J4N39_18030	COG3217	Mosc domain protein beta barrel domain protein
J4N39_18065	COG1301	dicarboxylic acid transport
J4N39_18070	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
J4N39_18080	COG2824	Alkylphosphonate utilization operon protein PhnA
J4N39_18090	COG0393	Putative heavy-metal-binding
J4N39_18105	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
J4N39_18120	COG0840	transmembrane signaling receptor activity
J4N39_18125	COG0346	lactoylglutathione lyase activity
J4N39_18180	COG3620	sequence-specific DNA binding
J4N39_18210	COG1802	Transcriptional regulator
J4N39_18210	COG4626	Terminase
J4N39_18220	COG1403	HNH endonuclease
J4N39_18305	COG1802	Transcriptional regulator
J4N39_18305	COG4626	Terminase
J4N39_18410	COG1063	alcohol dehydrogenase
J4N39_18425	COG2207	Transcriptional regulator
J4N39_18430	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
J4N39_18470	COG1289	transmembrane transporter activity
J4N39_18475	COG0210	DNA helicase
J4N39_18485	COG1803	Methylglyoxal synthase
J4N39_18490	COG1879	ABC-type sugar transport system periplasmic component
J4N39_18495	COG0784	Response regulator, receiver
J4N39_18495	COG2198	Histidine kinase
J4N39_18495	COG2205	protein histidine kinase activity
J4N39_18525	COG2205	protein histidine kinase activity
J4N39_18525	COG4999	Histidine kinase
J4N39_18525	COG3437	response regulator, receiver
J4N39_18525	COG3850	Histidine kinase
J4N39_18535	COG0516	GMP reductase activity
J4N39_18545	COG0583	DNA-binding transcription factor activity
J4N39_18560	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
J4N39_18565	COG1288	antiporter activity
J4N39_18570	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
J4N39_18570	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
J4N39_18575	COG1268	BioY protein
J4N39_18580	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
J4N39_18585	COG1122	ATPase activity
J4N39_18600	COG0778	Nitroreductase
J4N39_18610	COG5001	Diguanylate cyclase
J4N39_18610	COG3300	MHYT domain
J4N39_18620	COG2154	pterin-4-alpha-carbinolamine dehydratase
J4N39_18640	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
J4N39_18650	COG3550	peptidyl-serine autophosphorylation
J4N39_18655	COG1846	Transcriptional regulator
J4N39_18660	COG1764	response to oxidative stress
J4N39_18665	COG2205	protein histidine kinase activity
J4N39_18665	COG0784	Response regulator, receiver
J4N39_18685	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
J4N39_18690	COG0351	phosphomethylpyrimidine kinase
J4N39_18695	COG1116	anion transmembrane transporter activity
J4N39_18700	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
J4N39_18705	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
J4N39_18710	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
J4N39_18720	COG1324	tolerance protein
J4N39_18740	COG3118	belongs to the thioredoxin family
J4N39_18745	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
J4N39_18750	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
J4N39_18760	COG0840	transmembrane signaling receptor activity
J4N39_18780	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
J4N39_18785	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
J4N39_18790	COG1984	allophanate hydrolase subunit 2
J4N39_18805	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
J4N39_18810	COG4771	TonB-dependent receptor
J4N39_18815	COG0583	DNA-binding transcription factor activity
J4N39_18820	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
J4N39_18820	COG1042	CoA-binding domain protein
J4N39_18820	COG0045	succinate-CoA ligase (ADP-forming) activity
J4N39_18830	COG1181	Belongs to the D-alanine--D-alanine ligase family
J4N39_18845	COG0023	Translation Initiation Factor
J4N39_18855	COG3140	Belongs to the UPF0181 family
J4N39_18875	COG4191	Histidine kinase
J4N39_18880	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
J4N39_18885	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
J4N39_18900	COG3706	GGDEF domain
J4N39_18905	COG2203	Gaf domain
J4N39_18905	COG3706	GGDEF domain
J4N39_18905	COG4251	negative regulation of phosphorylation
J4N39_18905	COG5001	Diguanylate cyclase
J4N39_18925	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
J4N39_18930	COG4149	molybdate abc transporter
J4N39_18935	COG0725	ABC transporter, periplasmic molybdate-binding protein
J4N39_18940	COG1492	cobalamin metabolic process
J4N39_18955	COG4067	protein conserved in archaea
J4N39_18955	COG0189	ligase activity
J4N39_18965	COG0602	queuosine metabolic process
J4N39_18970	COG1328	CTP reductase activity
J4N39_18980	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
J4N39_18985	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
J4N39_18990	COG4181	ATPase activity
J4N39_19000	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
J4N39_19005	COG3300	MHYT domain
J4N39_19005	COG5001	Diguanylate cyclase
J4N39_19015	COG0737	Belongs to the 5'-nucleotidase family
J4N39_19020	COG3593	DNA synthesis involved in DNA repair
J4N39_19025	COG0583	DNA-binding transcription factor activity
J4N39_19030	COG2116	formate transmembrane transporter activity
J4N39_19035	COG2353	YceI-like domain
J4N39_19040	COG3038	cytochrome b561
J4N39_19045	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
J4N39_19095	COG1024	Enoyl-CoA hydratase
J4N39_19110	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
J4N39_19130	COG2050	protein possibly involved in aromatic compounds catabolism
J4N39_19140	COG2067	long-chain fatty acid transport protein
J4N39_19145	COG2267	carboxylic ester hydrolase activity
J4N39_19160	COG3042	response to heat
J4N39_19175	COG0668	transmembrane transport
J4N39_19195	COG2204	response regulator
J4N39_19200	COG4191	Histidine kinase
J4N39_19215	COG0110	maltose O-acetyltransferase activity
J4N39_19230	COG3300	MHYT domain
J4N39_19230	COG5001	Diguanylate cyclase
J4N39_19235	COG0737	Belongs to the 5'-nucleotidase family
J4N39_19240	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
J4N39_19245	COG0784	Response regulator, receiver
J4N39_19245	COG0835	chemotaxis
J4N39_19250	COG0748	coenzyme F420 binding
J4N39_19255	COG3721	Heme iron utilization protein
J4N39_19260	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
J4N39_19265	COG0811	peptide transport
J4N39_19270	COG0848	biopolymer transport protein
J4N39_19280	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
J4N39_19285	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
J4N39_19325	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
J4N39_19335	COG0501	Belongs to the peptidase M48B family
J4N39_19340	COG1704	LemA family
J4N39_19355	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
J4N39_19365	COG4989	oxidoreductase activity
J4N39_19370	COG0366	Alpha amylase catalytic
J4N39_19380	COG4191	Histidine kinase
J4N39_19380	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
J4N39_19440	COG3041	Addiction module toxin RelE StbE family
J4N39_19450	COG2944	sequence-specific DNA binding
J4N39_19455	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
J4N39_19460	COG1280	lysine exporter protein (LysE YggA)
J4N39_19495	COG0456	acetyltransferase
J4N39_19495	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
J4N39_19560	COG5433	transposase activity
J4N39_19600	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
J4N39_19645	COG3530	Putative quorum-sensing-regulated virulence factor
J4N39_19710	COG0588	phosphoglycerate mutase activity
J4N39_19720	COG0840	transmembrane signaling receptor activity
J4N39_19725	COG0513	Belongs to the DEAD box helicase family
J4N39_19730	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
J4N39_19755	COG2226	methyltransferase
J4N39_19765	COG0446	pyridine nucleotide-disulphide oxidoreductase
J4N39_19765	COG1902	pentaerythritol trinitrate reductase activity
J4N39_19790	COG3706	GGDEF domain
J4N39_19790	COG2203	Gaf domain
J4N39_19790	COG4251	negative regulation of phosphorylation
J4N39_19790	COG5001	Diguanylate cyclase
J4N39_19795	COG0625	glutathione transferase activity
J4N39_19800	COG0733	neurotransmitter:sodium symporter activity
J4N39_19805	COG0514	ATP-dependent DNA helicase (RecQ)
J4N39_19815	COG0784	Response regulator, receiver
J4N39_19815	COG2205	protein histidine kinase activity
J4N39_19820	COG2205	protein histidine kinase activity
J4N39_19820	COG0784	Response regulator, receiver
J4N39_19820	COG5002	protein histidine kinase activity
J4N39_19830	COG3104	oligopeptide transport
J4N39_19845	COG0784	Response regulator, receiver
J4N39_19845	COG5002	protein histidine kinase activity
J4N39_19845	COG2205	protein histidine kinase activity
J4N39_19865	COG0745	RESPONSE REGULATOR receiver
J4N39_19870	COG2205	protein histidine kinase activity
J4N39_19870	COG0784	Response regulator, receiver
J4N39_19870	COG5002	protein histidine kinase activity
J4N39_19875	COG3842	ATPase activity
J4N39_19880	COG0395	ABC-type sugar transport system, permease component
J4N39_19885	COG1175	transmembrane transport
J4N39_19890	COG1653	transport
J4N39_19895	COG0366	Alpha amylase catalytic
J4N39_19905	COG1309	transcriptional regulator
J4N39_19920	COG0494	nUDIX hydrolase
J4N39_19940	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
J4N39_19945	COG3706	GGDEF domain
J4N39_19950	COG4172	Belongs to the ABC transporter superfamily
J4N39_19965	COG0513	Belongs to the DEAD box helicase family
J4N39_19970	COG2211	Major facilitator Superfamily
J4N39_19975	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
J4N39_19980	COG2962	Rard protein
J4N39_19985	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
J4N39_20010	COG1132	(ABC) transporter
J4N39_20025	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
J4N39_20055	COG1278	Cold shock
J4N39_20060	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
J4N39_20070	COG1288	antiporter activity
J4N39_20095	COG3314	Sporulation integral membrane protein YlbJ
J4N39_20105	COG4191	Histidine kinase
J4N39_20110	COG3437	response regulator, receiver
J4N39_20110	COG0784	Response regulator, receiver
J4N39_20115	COG0640	Transcriptional regulator
J4N39_20120	COG3366	ferrous iron transmembrane transporter activity
J4N39_20125	COG0700	Nucleoside recognition
J4N39_20145	COG0513	Belongs to the DEAD box helicase family
J4N39_20195	COG0456	acetyltransferase
J4N39_20200	COG2425	protein containing a von Willebrand factor type A (vWA) domain
J4N39_20205	COG0714	Associated with various cellular activities
J4N39_20220	COG0513	Belongs to the DEAD box helicase family
J4N39_20230	COG0814	amino acid
J4N39_20250	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
J4N39_20260	COG3706	GGDEF domain
J4N39_20280	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
J4N39_20290	COG3040	lipid binding
J4N39_20300	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
J4N39_20315	COG1067	ATP-dependent peptidase activity
J4N39_20320	COG1741	Belongs to the pirin family
J4N39_20325	COG3123	guanosine phosphorylase activity
J4N39_20330	COG0840	transmembrane signaling receptor activity
J4N39_20335	COG5001	Diguanylate cyclase
J4N39_20335	COG4251	negative regulation of phosphorylation
J4N39_20335	COG3706	GGDEF domain
J4N39_20335	COG2203	Gaf domain
J4N39_20350	COG2271	Major facilitator Superfamily
J4N39_20355	COG2988	succinylglutamate desuccinylase activity
J4N39_20370	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
J4N39_20395	COG2017	converts alpha-aldose to the beta-anomer
J4N39_20405	COG0395	ABC-type sugar transport system, permease component
J4N39_20410	COG1175	transmembrane transport
J4N39_20420	COG0840	transmembrane signaling receptor activity
J4N39_20430	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
J4N39_20440	COG2249	NAD(P)H dehydrogenase (quinone) activity
J4N39_20450	COG1760	l-serine dehydratase
J4N39_20455	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
J4N39_20470	COG0456	acetyltransferase
J4N39_20485	COG0848	biopolymer transport protein
J4N39_20490	COG0811	peptide transport
J4N39_20495	COG0811	peptide transport
J4N39_20510	COG0745	RESPONSE REGULATOR receiver
J4N39_20515	COG3706	GGDEF domain
J4N39_20530	COG0318	PFAM AMP-dependent synthetase and ligase
J4N39_20550	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
J4N39_20595	COG0110	maltose O-acetyltransferase activity
J4N39_20620	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
J4N39_20625	COG0515	serine threonine protein kinase
J4N39_20625	COG2815	serine threonine protein kinase
J4N39_20630	COG2116	formate transmembrane transporter activity
J4N39_20645	COG0737	Belongs to the 5'-nucleotidase family
J4N39_20660	COG1309	transcriptional regulator
J4N39_20685	COG1472	Belongs to the glycosyl hydrolase 3 family
J4N39_20700	COG4977	sequence-specific DNA binding
J4N39_20705	COG4580	involved in the transport of maltose and maltodextrins
J4N39_20750	COG4608	Belongs to the ABC transporter superfamily
J4N39_20755	COG0444	Belongs to the ABC transporter superfamily
J4N39_20760	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
J4N39_20770	COG0747	negative chemotaxis
J4N39_20830	COG1012	belongs to the aldehyde dehydrogenase family
J4N39_20840	COG0443	Heat shock 70 kDa protein
J4N39_20855	COG4604	ABC transporter, ATP-binding protein
J4N39_20860	COG4605	iron ion homeostasis
J4N39_20865	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
J4N39_20875	COG4771	TonB-dependent receptor
J4N39_20880	COG0583	DNA-binding transcription factor activity
J4N39_20885	COG1175	transmembrane transport
J4N39_20890	COG0395	ABC-type sugar transport system, permease component
J4N39_20895	COG3842	ATPase activity
J4N39_20900	COG5433	transposase activity
J4N39_20905	COG3842	ATPase activity
J4N39_20915	COG0534	Mate efflux family protein
J4N39_20920	COG0583	DNA-binding transcription factor activity
J4N39_20925	COG0534	Mate efflux family protein
J4N39_20930	COG0583	DNA-binding transcription factor activity
J4N39_20950	COG1108	ABC-type Mn2 Zn2 transport systems permease components
J4N39_20955	COG1121	(ABC) transporter
J4N39_21050	COG0179	Fumarylacetoacetate (FAA) hydrolase
J4N39_21055	COG0419	ATPase involved in DNA repair
J4N39_21060	COG0420	3'-5' exonuclease activity
J4N39_21105	COG0330	HflC and HflK could
J4N39_21110	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
J4N39_21120	COG0583	DNA-binding transcription factor activity
J4N39_21130	COG3833	ABC-type maltose transport systems, permease component
J4N39_21135	COG1175	transmembrane transport
J4N39_21145	COG3842	ATPase activity
J4N39_21180	COG1462	curli production assembly transport component CsgG
J4N39_21230	COG0714	Associated with various cellular activities
J4N39_21245	COG2304	oxidoreductase activity
J4N39_21250	COG2304	oxidoreductase activity
J4N39_21260	COG1979	alcohol dehydrogenase
J4N39_21265	COG0612	Peptidase, M16
J4N39_21275	COG2814	Major facilitator Superfamily
J4N39_21280	COG0583	DNA-binding transcription factor activity
J4N39_21305	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
J4N39_21315	COG1280	lysine exporter protein (LysE YggA)
J4N39_21340	COG4221	oxidoreductase activity
J4N39_21345	COG3038	cytochrome b561
J4N39_21350	COG1785	Belongs to the alkaline phosphatase family
J4N39_21365	COG1028	Short-chain dehydrogenase reductase Sdr
J4N39_21370	COG2226	methyltransferase
J4N39_21395	COG1228	amidohydrolase
J4N39_21415	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
J4N39_21425	COG0251	oxidation-reduction process
J4N39_21440	COG1917	Cupin 2, conserved barrel domain protein
J4N39_21440	COG2207	Transcriptional regulator
J4N39_21465	COG4782	Protein conserved in bacteria
J4N39_21480	COG0583	DNA-binding transcription factor activity
J4N39_21485	COG1620	l-lactate permease
J4N39_21495	COG1139	Iron-sulfur cluster binding protein
J4N39_21505	COG0277	FAD linked oxidase domain protein
J4N39_21505	COG0247	lactate metabolic process
J4N39_21510	COG3916	Acyl-homoserine-lactone synthase
J4N39_21520	COG2197	response regulator
J4N39_21535	COG1105	Belongs to the carbohydrate kinase PfkB family
J4N39_21540	COG4702	Belongs to the UPF0303 family
J4N39_21545	COG0673	inositol 2-dehydrogenase activity
J4N39_21550	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
J4N39_21550	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
J4N39_21550	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
J4N39_21555	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
J4N39_21560	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
J4N39_21565	COG1882	Formate acetyltransferase
J4N39_21570	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
J4N39_21575	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
J4N39_21580	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
J4N39_21585	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
J4N39_21590	COG2207	Transcriptional regulator
J4N39_21605	COG1275	C4-dicarboxylate transporter malic acid transport protein
J4N39_21615	COG0488	(ABC) transporter
J4N39_21620	COG3135	benzoate transporter
J4N39_21625	COG1396	sequence-specific DNA binding
J4N39_21630	COG0494	nUDIX hydrolase
J4N39_21660	COG2095	MarC family integral membrane protein
J4N39_21690	COG2200	EAL domain
J4N39_21690	COG2199	diguanylate cyclase activity
J4N39_21715	COG2188	Transcriptional regulator
J4N39_21720	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
J4N39_21720	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
J4N39_21720	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
J4N39_21725	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
J4N39_21725	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
J4N39_21725	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
J4N39_21730	COG0383	alpha-mannosidase activity
J4N39_21735	COG1929	Belongs to the glycerate kinase type-1 family
J4N39_21740	COG1482	cell wall glycoprotein biosynthetic process
J4N39_21765	COG0589	response to stress
J4N39_21780	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
J4N39_21785	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
J4N39_21790	COG0805	protein transport
J4N39_21825	COG1121	(ABC) transporter
J4N39_21830	COG1108	ABC-type Mn2 Zn2 transport systems permease components
J4N39_21840	COG4774	siderophore transport
J4N39_21845	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
J4N39_21855	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
J4N39_21885	COG0800	Aldolase
J4N39_21890	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
J4N39_21895	COG1917	Cupin 2, conserved barrel domain protein
J4N39_21920	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
J4N39_21930	COG1609	Transcriptional regulator
J4N39_21935	COG0583	DNA-binding transcription factor activity
J4N39_21950	COG1917	Cupin 2, conserved barrel domain protein
J4N39_21955	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
J4N39_21990	COG3321	synthase
J4N39_21990	COG1028	Short-chain dehydrogenase reductase Sdr
J4N39_21990	COG0604	alcohol dehydrogenase
J4N39_21995	COG1247	-acetyltransferase
J4N39_22000	COG0366	Alpha amylase catalytic
J4N39_22005	COG0583	DNA-binding transcription factor activity
J4N39_22020	COG2186	Transcriptional regulator
J4N39_22025	COG1028	Short-chain dehydrogenase reductase Sdr
J4N39_22030	COG2186	Transcriptional regulator
J4N39_22040	COG3181	Tripartite tricarboxylate transporter family receptor
J4N39_22070	COG4607	ABC-type enterochelin transport system periplasmic component
J4N39_22095	COG3046	protein related to deoxyribodipyrimidine photolyase
J4N39_22100	COG0415	Belongs to the DNA photolyase family
J4N39_22105	COG1418	mRNA catabolic process
J4N39_22110	COG1609	Transcriptional regulator
J4N39_22115	COG4948	Mandelate Racemase Muconate Lactonizing
J4N39_22125	COG5001	Diguanylate cyclase
J4N39_22125	COG3300	MHYT domain
J4N39_22145	COG0517	IMP dehydrogenase activity
J4N39_22155	COG5520	Belongs to the glycosyl hydrolase 30 family
J4N39_22155	COG3291	Pkd domain containing protein
J4N39_22155	COG4447	cellulose binding
J4N39_22160	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
J4N39_22165	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
J4N39_22175	COG2165	general secretion pathway protein
J4N39_22195	COG0646	methionine synthase
J4N39_22195	COG1410	methionine synthase
J4N39_22200	COG2084	Dehydrogenase
J4N39_22210	COG0577	efflux transmembrane transporter activity
J4N39_22220	COG2213	PTS system mannitol-specific
J4N39_22220	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
J4N39_22230	COG3722	fumarate hydratase activity
J4N39_22235	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
J4N39_22255	COG1349	DNA-binding transcription factor activity
J4N39_22260	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
J4N39_22265	COG1262	PFAM Formylglycine-generating sulfatase enzyme
J4N39_22275	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
J4N39_22345	COG0484	heat shock protein binding
J4N39_22365	COG5001	Diguanylate cyclase
J4N39_22365	COG4251	negative regulation of phosphorylation
J4N39_22365	COG3706	GGDEF domain
J4N39_22365	COG2203	Gaf domain
J4N39_22400	COG0583	DNA-binding transcription factor activity
J4N39_22415	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
J4N39_22420	COG1482	cell wall glycoprotein biosynthetic process
J4N39_22425	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
J4N39_22425	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
J4N39_22425	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
J4N39_22430	COG2207	Transcriptional regulator
J4N39_22440	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
J4N39_22445	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
J4N39_22465	COG1482	cell wall glycoprotein biosynthetic process
J4N39_22480	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
J4N39_22485	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
J4N39_22495	COG1609	Transcriptional regulator
J4N39_22515	COG0395	ABC-type sugar transport system, permease component
J4N39_22520	COG1175	transmembrane transport
J4N39_22525	COG1028	Short-chain dehydrogenase reductase Sdr
J4N39_22540	COG0583	DNA-binding transcription factor activity
J4N39_22550	COG1028	Short-chain dehydrogenase reductase Sdr
J4N39_22560	COG0589	response to stress
J4N39_22565	COG0786	glutamate:sodium symporter activity
J4N39_22595	COG0583	DNA-binding transcription factor activity
J4N39_22645	COG0625	glutathione transferase activity
J4N39_22685	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
J4N39_22695	COG1566	PFAM secretion protein HlyD family protein
J4N39_22705	COG0745	RESPONSE REGULATOR receiver
J4N39_22710	COG0642	Histidine kinase
J4N39_22725	COG0300	oxidoreductase activity
J4N39_22735	COG0583	DNA-binding transcription factor activity
J4N39_22770	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
J4N39_22770	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
J4N39_22770	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
J4N39_22775	COG1105	Belongs to the carbohydrate kinase PfkB family
J4N39_22780	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
J4N39_22780	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
J4N39_22785	COG1609	Transcriptional regulator
J4N39_22790	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
J4N39_22815	COG2801	Transposase and inactivated derivatives
J4N39_22830	COG1108	ABC-type Mn2 Zn2 transport systems permease components
J4N39_22835	COG1108	ABC-type Mn2 Zn2 transport systems permease components
J4N39_22840	COG1121	(ABC) transporter
J4N39_22855	COG0259	pyridoxamine-phosphate oxidase activity
J4N39_22875	COG2274	protein secretion by the type I secretion system
J4N39_22890	COG0745	RESPONSE REGULATOR receiver
J4N39_22915	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
J4N39_22920	COG0840	transmembrane signaling receptor activity
J4N39_22925	COG0835	chemotaxis
J4N39_22940	COG0745	RESPONSE REGULATOR receiver
J4N39_22950	COG1444	tRNA N-acetyltransferase activity