locus-tag	class	description
VS_0001	ENOG4105QTB	Flavodoxin
VS_0002	ENOG4105C1H	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity)
VS_0003	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
VS_0004	ENOG4105VAS	Could be involved in insertion of integral membrane proteins into the membrane (By similarity)
VS_0005	ENOG4105NVJ	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)
VS_0006	ENOG4105VG0	50S ribosomal protein l34
VS_0008	ENOG4105E5Q	amino acid AbC transporter
VS_0009	ENOG4105EAB	amino acid AbC transporter
VS_0010	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
VS_0011	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
VS_0012	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
VS_0013	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
VS_0015	ENOG4105JKW	Valine--pyruvate aminotransferase
VS_0029	ENOG4105UYK	outer membrane protein a
VS_0030	ENOG4105IFJ	Histidine kinase
VS_0032	ENOG4105C38	Glycyl-tRNA synthetase beta subunit
VS_0033	ENOG4108HMW	glycyl-tRNA synthetase, alpha subunit
VS_0037	ENOG41082K8	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity)
VS_0039	ENOG4105D3Z	quinone oxidoreductase, yhdh yhfp family
VS_0040	ENOG4105CHU	acetyl-coa acetyltransferase
VS_0041	ENOG4105DYT	3-hydroxyacyl-CoA dehydrogenase
VS_0042	ENOG4108ZK7	protein family UPF0029, Impact, N-terminal protein
VS_0043	ENOG4105D37	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity)
VS_0044	ENOG4108RR8	protoporphyrinogen oxidase
VS_0060	ENOG4105EMY	transcriptional regulator
VS_0061	ENOG4105C6M	Alpha-keto-beta-hydroxylacyl reductoisomerase
VS_0062	ENOG4105W0Z	cytoplasmic protein
VS_0063	ENOG4105BZS	acriflavin resistance protein
VS_0064	ENOG410624X	efflux transporter, rnd family, mfp subunit
VS_0065	ENOG4105Y7M	Transcriptional regulator, TetR family
VS_0066	ENOG4105C4R	Atp-dependent dna helicase
VS_0067	ENOG4105MPD	Cytochrome
VS_0076	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
VS_0077	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
VS_0079	ENOG4108J5C	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
VS_0082	ENOG4105DC8	reductase
VS_0083	ENOG4105D6S	protein involved in catabolism of external DNA
VS_0084	ENOG4105DGW	oligopeptidase A
VS_0085	ENOG4108VVK	transcriptional Regulator, AsnC
VS_0086	ENOG4105BZU	Histidine kinase
VS_0087	ENOG4105FFN	Specifically methylates the guanosine in position 1516 of 16S rRNA (By similarity)
VS_0089	ENOG4105EMK	carboxylate amino acid amine transporter
VS_0090	ENOG4108M6U	Universal stress protein A
VS_0091	ENOG41090A1	ferritin
VS_0092	ENOG4108V6B	universal stress protein B
VS_0094	ENOG4105CBX	hi0933 family
VS_0097	ENOG4105CGY	Dna recombination protein
VS_0098	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
VS_0099	ENOG4105JC1	sterol-binding domain protein
VS_0100	ENOG4105CNK	Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity)
VS_0101	ENOG4105WKS	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity)
VS_0102	ENOG4105X8U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity)
VS_0103	ENOG4105DCX	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity)
VS_0104	ENOG4105F8V	Hydrolase, tatD family
VS_0105	ENOG4105D52	delta-aminolevulinic acid dehydratase
VS_0108	ENOG4105C2M	dna polymerase I
VS_0111	ENOG4105WHM	Necessary for normal cell division and for the maintenance of normal septation (By similarity)
VS_0112	ENOG4106RE7	Cytochrome
VS_0114	ENOG4105ZR3	A GTPase-activating protein (GAP) that modifies Der EngA GTPase function. May play a role in ribosome biogenesis (By similarity)
VS_0115	ENOG4105XCT	Protein of unknown function (DUF2489)
VS_0116	ENOG4105D4P	Coproporphyrinogen iii oxidase
VS_0117	ENOG4105BZU	Histidine kinase
VS_0118	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
VS_0119	ENOG4105CUX	Signal transduction histidine kinase
VS_0121	ENOG4105C5F	glutamine synthetase
VS_0123	ENOG4105CI3	gtp-binding protein typa
VS_0126	ENOG4107S2Z	UPF0761 membrane protein
VS_0127	ENOG4108YYA	Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity)
VS_0128	ENOG4105SUU	thioesterase domain
VS_0131	ENOG4105DJ1	Phosphoenolpyruvate Carboxylase
VS_0132	ENOG4105F4C	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity)
VS_0133	ENOG4105VEJ	Heat shock protein
VS_0134	ENOG4108XKW	General secretion pathway protein C
VS_0136	ENOG4107QHF	type ii secretion system protein e
VS_0137	ENOG4105D7Q	type ii secretion system
VS_0138	ENOG4108VAU	general secretion pathway protein G
VS_0139	ENOG4105VWV	general secretion pathway protein h
VS_0140	ENOG4105X5Z	General secretion pathway protein I
VS_0141	ENOG4108WWZ	General secretion pathway protein J
VS_0142	ENOG4108RTD	type II secretion system protein K
VS_0143	ENOG4108BY5	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins (By similarity)
VS_0144	ENOG4105U1E	general secretion pathway protein M
VS_0145	ENOG4105PIC	general secretion pathway protein N
VS_0146	ENOG4108RNI	3'(2')5'-bisphosphate nucleotidase
VS_0147	ENOG4107RK2	ADP-ribose diphosphatase NudE
VS_0148	ENOG4107RUK	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins (By similarity)
VS_0149	ENOG4105MJ2	Competence protein
VS_0150	ENOG4105D3C	The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity)
VS_0153	ENOG4105BZM	domain protein
VS_0155	ENOG4108RRZ	Transcription elongation factor GreB
VS_0156	ENOG4105DPZ	Two component transcriptional regulator (Winged helix family
VS_0157	ENOG4105E0F	Histidine kinase
VS_0158	ENOG4105CB5	ATP-dependent DNA helicase recG
VS_0159	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
VS_0160	ENOG4105VFG	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity)
VS_0161	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
VS_0162	ENOG4105C7N	Xanthine uracil vitamin C permease
VS_0165	ENOG4105CI1	PTS System
VS_0167	ENOG4105E66	phosphoriboisomerase A
VS_0169	ENOG4105CW3	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity)
VS_0170	ENOG4107YBY	Hydrolase
VS_0171	ENOG4108JB8	alcohol dehydrogenase
VS_0173	ENOG410667J	hydrolase
VS_0174	ENOG4105DW5	Transcriptional regulator
VS_0175	ENOG4105VEQ	Cold shock protein
VS_0176	ENOG4105DSJ	YicC domain protein
VS_0177	ENOG4105ED0	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity)
VS_0178	ENOG4107QP2	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
VS_0179	ENOG4105D1S	lipid A biosynthesis
VS_0180	ENOG4105EC0	Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity)
VS_0182	ENOG4105W5Q	DNA repair protein (RadC
VS_0183	ENOG4105KDC	50s ribosomal protein l28
VS_0184	ENOG4105W0E	50S ribosomal protein L33
VS_0186	ENOG4105ERD	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity)
VS_0187	ENOG4108JMC	lipopolysaccharide core biosynthesis protein
VS_0188	ENOG4105XA0	heptosyltransferase ii
VS_0189	ENOG4105D8A	3-Deoxy-D-manno-octulosonic-acid transferase
VS_0192	ENOG4108W7E	Catalyzes the ATP-dependent phosphorylation of the 3- deoxy-D-manno-octulosonic acid (Kdo) residue in Kdo-lipid IV(A) at the 4-OH position (By similarity)
VS_0194	ENOG4105DKP	glycosyl transferase, family 9
VS_0195	ENOG4108ZEF	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)
VS_0197	ENOG410650X	lipopolysaccharide core region biosynthetic process
VS_0199	ENOG4105NWR	lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase
VS_0202	ENOG41062JF	Transcriptional regulator
VS_0203	ENOG41063SB	peptidase
VS_0204	ENOG4105D7W	serine acetyltransferase
VS_0205	ENOG4105CSF	NADPH-dependent glycerol-3-phosphate dehydrogenase
VS_0206	ENOG4105IX2	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity)
VS_0207	ENOG4107YZP	Rhodanese domain protein
VS_0212	ENOG4105E3R	(LipO)protein
VS_0213	ENOG4105DAY	polysaccharide export protein
VS_0215	ENOG4105D75	Capsular exopolysaccharide family
VS_0216	ENOG4105CXR	Phospho-2-dehydro-3-deoxyoctonate aldolase
VS_0217	ENOG4108Z4R	3-deoxy-d-manno-octulosonate 8-phosphate phosphatase
VS_0218	ENOG4105CET	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity)
VS_0219	ENOG4105C2X	Arabinose 5-phosphate isomerase
VS_0225	ENOG4108UW5	maltose o-acetyltransferase
VS_0226	ENOG4108TMJ	glycosyl transferase
VS_0227	ENOG4105C1B	dTDP-glucose 4-6-dehydratase
VS_0229	ENOG4108URP	Dtdp-4-dehydrorhamnose 3,5-epimerase
VS_0231	ENOG4108RT7	Glycosyl transferase, family 2
VS_0233	ENOG4105D3Q	Sugar transferase
VS_0235	ENOG4105CJI	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
VS_0236	ENOG4107QI1	Mate efflux family protein
VS_0237	ENOG4105SFE	lipopolysaccharide biosynthesis protein
VS_0238	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
VS_0239	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
VS_0241	ENOG4105BZU	Histidine kinase
VS_0242	ENOG4105KT7	mgtC SapB transporter
VS_0243	ENOG4105CK3	Lysine 2,3-aminomutase YodO family protein
VS_0244	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
VS_0245	ENOG4108VP9	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity)
VS_0246	ENOG4108WJH	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity)
VS_0249	ENOG4105CAP	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity)
VS_0251	ENOG4105C8Q	Methyl-accepting chemotaxis
VS_0252	ENOG4107QWE	)-transporter
VS_0253	ENOG4105DJ4	phosphatidylserine decarboxylase
VS_0254	ENOG4105E06	May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity)
VS_0255	ENOG4108RBP	3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity)
VS_0265	ENOG4105EH2	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity)
VS_0266	ENOG4105K8N	protein family UPF0079, ATPase
VS_0267	ENOG4105C5C	n-acetylmuramoyl-l-alanine amidase
VS_0268	ENOG4105DC6	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity)
VS_0269	ENOG4105DKX	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)
VS_0270	ENOG4105KW8	RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity)
VS_0271	ENOG4105C1N	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity)
VS_0272	ENOG4107QJR	hflk protein
VS_0273	ENOG4105EPW	hflc protein
VS_0275	ENOG4105C91	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
VS_0276	ENOG4108UV7	flagellar protein motX
VS_0277	ENOG4107SYB	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity)
VS_0278	ENOG4105C40	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity)
VS_0279	ENOG4105C2N	RNA methyltransferase TrmH family group 3
VS_0281	ENOG4105VH8	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity)
VS_0282	ENOG4105K9Q	Binds to the 23S rRNA (By similarity)
VS_0284	ENOG4105CDU	Replicative dna helicase
VS_0285	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
VS_0287	ENOG4108YXI	Secondary thiamine-phosphate synthase enzyme
VS_0288	ENOG4107QP8	phosphohexose isomerase
VS_0290	ENOG4105MYN	Zinc uptake regulation protein
VS_0294	ENOG4105CEH	Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity)
VS_0296	ENOG4105P4Z	Phage shock protein G
VS_0299	ENOG4107EER	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity)
VS_0300	ENOG4105ET1	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity)
VS_0301	ENOG4105ET3	Reduction of activated sulfate into sulfite (By similarity)
VS_0314	ENOG4105EEQ	Na H antiporter
VS_0315	ENOG4105C3R	Methionine synthase
VS_0316	ENOG4105CFH	Aspartokinase
VS_0318	ENOG4105C5R	Aminotransferase
VS_0320	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
VS_0321	ENOG4105C3Y	UTP-glucose-1-phosphate uridylyltransferase
VS_0322	ENOG41086KC	Transcriptional regulator
VS_0323	ENOG4108UUM	single-stranded DNA-binding protein
VS_0324	ENOG41062P1	Diguanylate cyclase phosphodiesterase
VS_0331	ENOG4107QHF	type ii secretion system protein e
VS_0332	ENOG4105D7Q	type ii secretion system
VS_0341	ENOG4105DFF	Rod shape-determining protein mreb
VS_0342	ENOG4105N3I	Involved in formation and maintenance of cell shape (By similarity)
VS_0343	ENOG4105VQ7	Rod shape-determining protein MreD
VS_0344	ENOG4108Z03	MAF-like protein
VS_0345	ENOG4105C03	ribonuclease
VS_0346	ENOG4105QD6	exported protein
VS_0348	ENOG4105D1U	peptidase U62 modulator of DNA gyrase
VS_0349	ENOG4108IAB	Phoh family
VS_0350	ENOG4105BZK	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity)
VS_0351	ENOG4105D3G	Pseudouridine synthase
VS_0352	ENOG4105C5I	Dehydrogenase
VS_0353	ENOG41081QV	Universal stress protein
VS_0357	ENOG410682Y	Regulates arginine biosynthesis genes (By similarity)
VS_0358	ENOG4105C80	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
VS_0360	ENOG4105EAH	synthase
VS_0361	ENOG4105KK9	This protein binds to 23S rRNA in the presence of protein L20 (By similarity)
VS_0362	ENOG4105K46	50S ribosomal protein l27
VS_0363	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
VS_0366	ENOG4107XM3	UPF0442 protein
VS_0368	ENOG4105DDT	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity)
VS_0369	ENOG4105NWN	ApaG protein
VS_0370	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
VS_0371	ENOG4105CEZ	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity)
VS_0373	ENOG4105E7H	involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity)
VS_0374	ENOG41066UG	Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity)
VS_0377	ENOG4105MQS	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
VS_0379	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
VS_0380	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
VS_0386	ENOG41064T2	transcriptional regulator, lysR family
VS_0387	ENOG4108IQE	Amp-dependent synthetase and ligase
VS_0388	ENOG4105C7K	acetolactate synthase
VS_0389	ENOG4108ZP8	Acetolactate synthase small subunit
VS_0392	ENOG4105CA9	Pyruvate kinase
VS_0393	ENOG410804X	Transcriptional regulator
VS_0394	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
VS_0395	ENOG4108IQK	o-acetylhomoserine
VS_0397	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
VS_0398	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
VS_0399	ENOG4105KTH	gatB Yqey
VS_0400	ENOG4105VCC	30S ribosomal protein S21
VS_0401	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
VS_0402	ENOG4108WC5	Alpha Beta Hydrolase Fold protein
VS_0403	ENOG4105K7Z	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity)
VS_0404	ENOG4107ZVW	dihydroneopterin aldolase
VS_0405	ENOG4105K8U	2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
VS_0406	ENOG4105DWR	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity)
VS_0407	ENOG4105D4J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
VS_0410	ENOG4106MWK	domain protein
VS_0411	ENOG4105CJ3	phosphate transporter
VS_0412	ENOG4107IX6	phosphate transport regulator
VS_0413	ENOG4105I7R	Adenylate cyclase
VS_0415	ENOG4105C8Q	Methyl-accepting chemotaxis
VS_0416	ENOG4105CE6	Adenylation and deadenylation of glutamate--ammonia ligase (By similarity)
VS_0417	ENOG4105DW0	Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity)
VS_0418	ENOG4105DFG	type I secretion outer membrane protein
VS_0419	ENOG41087AY	ADP-Ribose pyrophosphatase
VS_0420	ENOG4108SX3	cytoplasmic protein
VS_0421	ENOG41070EG	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity)
VS_0422	ENOG4105IPS	esterase
VS_0423	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
VS_0424	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
VS_0425	ENOG4105C0H	protease
VS_0426	ENOG4105C0H	protease
VS_0427	ENOG4108W2Q	Cytochrome d ubiquinol oxidase subunit III
VS_0428	ENOG4105D6Z	AFG1 family ATPase
VS_0429	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
VS_0430	ENOG4108UJD	30S ribosomal protein S9
VS_0431	ENOG4108R5F	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
VS_0432	ENOG4105DJ5	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
VS_0433	ENOG4105EIX	cytochrome c1
VS_0434	ENOG4107MKT	Stringent starvation protein a
VS_0435	ENOG4105KB2	stringent starvation protein b
VS_0436	ENOG4105W4M	Transport-associated protein
VS_0437	ENOG4105F55	Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity)
VS_0438	ENOG41082RQ	UPF0102 protein
VS_0440	ENOG4105CU0	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity)
VS_0442	ENOG4105CGJ	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity)
VS_0443	ENOG41063Y6	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity)
VS_0444	ENOG4105CJN	penicillin-binding protein
VS_0445	ENOG4107EEN	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity)
VS_0446	ENOG4108EQQ	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity)
VS_0447	ENOG4105CPY	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity)
VS_0448	ENOG4105DMZ	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity)
VS_0450	ENOG4105DVQ	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity)
VS_0451	ENOG4105DFU	Cell wall formation (By similarity)
VS_0452	ENOG4105K7E	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity)
VS_0453	ENOG4105CIT	This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity)
VS_0454	ENOG4105CDK	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity)
VS_0455	ENOG4105C7C	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
VS_0456	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
VS_0459	ENOG4105M6F	mutator MutT protein
VS_0460	ENOG4105DUK	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity)
VS_0461	ENOG4105C1M	carbamoyl-phosphate synthetase glutamine chain
VS_0462	ENOG4105CU6	carbamoyl-phosphate synthetase ammonia chain
VS_0463	ENOG4105EJ9	Membrane
VS_0464	ENOG4105VP0	transcriptional regulator, lysR family
VS_0465	ENOG4105EN6	Membrane
VS_0466	ENOG4105JKQ	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity)
VS_0468	ENOG4105DUF	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity)
VS_0470	ENOG4105BZ8	glutamate synthase
VS_0471	ENOG4105CBC	glutamate synthase
VS_0472	ENOG4105CBC	glutamate synthase
VS_0475	ENOG4105N5T	Radical SAM Protein
VS_0477	ENOG4105BZU	Histidine kinase
VS_0479	ENOG41065U4	response regulator
VS_0480	ENOG4108YYX	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity)
VS_0484	ENOG4105D5I	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity)
VS_0485	ENOG4105D98	threonine synthase
VS_0498	ENOG4108VKA	Acts as a radical domain for damaged PFL and possibly other radical proteins (By similarity)
VS_0499	ENOG4105EFU	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity)
VS_0501	ENOG4105D5S	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity)
VS_0504	ENOG4105BZG	amino acid carrier protein
VS_0505	ENOG4105D1Q	UPF0246 protein
VS_0506	ENOG4105C1J	atp-dependent rna helicase
VS_0507	ENOG4107S47	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity)
VS_0508	ENOG4105CWM	branched-chain amino acid transport system II carrier protein
VS_0511	ENOG41071R3	Low-potential electron donor to a number of redox enzymes (By similarity)
VS_0512	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
VS_0513	ENOG4105T95	Thiol disulfide interChange protein
VS_0514	ENOG4105C2R	Single-stranded-DNA-specific exonuclease (RecJ)
VS_0516	ENOG4105CG1	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity)
VS_0517	ENOG4105CRK	lysyL-tRNA synthetase
VS_0522	ENOG4105IRT	Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair (By similarity)
VS_0523	ENOG4105EJF	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity)
VS_0524	ENOG4108HRM	phosphoenolpyruvate--protein phosphotransferase
VS_0525	ENOG4105HF0	Membrane
VS_0526	ENOG4105C3B	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity)
VS_0527	ENOG4105C0V	Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity)
VS_0528	ENOG4105EEX	Two component transcriptional regulator (Winged helix family
VS_0531	ENOG41063Z6	transcriptional regulator, lysR family
VS_0532	ENOG41080HT	Transcriptional regulator, arsr family
VS_0533	ENOG4105KQV	Binds directly to 16S ribosomal RNA (By similarity)
VS_0534	ENOG4105CJR	Integral membrane protein (MviN
VS_0535	ENOG4105DTN	riboflavin biosynthesis protein ribF
VS_0536	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
VS_0537	ENOG4105M02	This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity)
VS_0538	ENOG41090X3	Peptidyl-prolyl cis-trans isomerase
VS_0539	ENOG4105C48	Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity)
VS_0540	ENOG4108NEV	two component transcriptional regulator, LytTR family
VS_0541	ENOG4108HRK	Histidine kinase
VS_0544	ENOG4105E15	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
VS_0545	ENOG4105ED7	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity)
VS_0546	ENOG4107QPA	Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity)
VS_0547	ENOG4105E99	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity)
VS_0549	ENOG4105DR5	peptidase
VS_0551	ENOG4105C5H	ABC transporter
VS_0552	ENOG4107SC1	transglycosylase
VS_0553	ENOG4105R9M	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region (By similarity)
VS_0554	ENOG4108K16	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
VS_0555	ENOG4108K0B	C-di-gmp phosphodiesterase
VS_0557	ENOG4108WPH	sigma 54 modulation protein ribosomal protein S30EA
VS_0558	ENOG4105E4C	Lytic transglycosylase catalytic
VS_0559	ENOG4106SNF	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VS_0560	ENOG4105C34	Pseudouridine synthase
VS_0561	ENOG4105DBW	Multi-copper polyphenol oxidoreductase laccase
VS_0562	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
VS_0574	ENOG4105HPZ	Involved in the removal of murein from the sacculus. May also facilitate integration of nascent murein strands into the sacculus by cleaving the peptide bonds between neighboring strands in mature murein (By similarity)
VS_0576	ENOG4105K5D	4fe-4S ferredoxin iroN-sulfur binding
VS_0577	ENOG4105CFP	Peptidase U32
VS_0578	ENOG4105DH7	May be involved in recombination (By similarity)
VS_0579	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
VS_0580	ENOG4105BZU	Histidine kinase
VS_0582	ENOG4105C9X	ppx gppa phosphatase
VS_0583	ENOG4105CUU	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity)
VS_0585	ENOG4105C8U	phosphate abc transporter
VS_0586	ENOG4105E2Z	phosphate ABC transporter (Permease
VS_0587	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
VS_0592	ENOG4106N3A	copper homeostasis protein cutc
VS_0593	ENOG4105D3R	alkyl hydroperoxide reductase
VS_0594	ENOG4105C5Q	Transcriptional regulator
VS_0597	ENOG4105W87	Cbs domain
VS_0598	ENOG4105E2N	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity)
VS_0599	ENOG4105C6U	Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity)
VS_0600	ENOG4105VIE	preprotein translocase, subunit YajC
VS_0601	ENOG4107QN8	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
VS_0602	ENOG4107RAB	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
VS_0604	ENOG4105ECY	inositol monophosphatase
VS_0605	ENOG4105CVS	RNA methyltransferase TrmH family, group 1
VS_0606	ENOG4108ZF1	Transcriptional regulator, BadM Rrf2 family
VS_0607	ENOG4105C3J	Cysteine desulfurase
VS_0608	ENOG4107XTC	May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins
VS_0609	ENOG4108Z4V	iron-sulfur cluster assembly
VS_0610	ENOG4108SWN	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity)
VS_0611	ENOG4105C9I	Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB
VS_0612	ENOG4108ZIT	Ferredoxin, 2FE-2S
VS_0613	ENOG4105WVQ	Fe-S assembly protein IscX
VS_0614	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
VS_0615	ENOG4108UGX	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity)
VS_0616	ENOG4105C55	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
VS_0618	ENOG4105HSZ	Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis (By similarity)
VS_0619	ENOG4105C4E	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity)
VS_0620	ENOG4105CUT	histidyl-tRNA synthetase
VS_0621	ENOG4105N21	Membrane
VS_0622	ENOG4105CNE	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity)
VS_0623	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
VS_0624	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
VS_0625	ENOG4105BZU	Histidine kinase
VS_0627	ENOG4105DVS	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
VS_0628	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
VS_0629	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
VS_0632	ENOG4106HK8	GPR1 FUN34 yaaH family protein
VS_0633	ENOG4105BZG	amino acid carrier protein
VS_0634	ENOG4105CY0	Metallo-Beta-Lactamase
VS_0635	ENOG4107S7E	1-acyl-sn-glycerol-3-phosphate acyltransferase
VS_0640	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
VS_0642	ENOG4108UH4	Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity)
VS_0643	ENOG4108Z1B	Cyclase dehydrase
VS_0644	ENOG4105VDB	UPF0125 protein
VS_0645	ENOG4105YRI	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity)
VS_0646	ENOG4105C4F	May be involved in recombinational repair of damaged DNA (By similarity)
VS_0648	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
VS_0649	ENOG4105K90	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
VS_0650	ENOG4107QJT	sodium dicarboxylate symporter
VS_0651	ENOG4105CFG	Acts as a chaperone (By similarity)
VS_0652	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
VS_0659	ENOG4105CFC	Transporter
VS_0661	ENOG4108Z6B	deaminase
VS_0663	ENOG4105CHQ	Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity)
VS_0664	ENOG4108ETH	Formylglycinamide ribotide synthetase
VS_0666	ENOG4105EJ3	Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA (By similarity)
VS_0667	ENOG4105EZI	multiple antibiotic resistance (MarC)-related protein
VS_0670	ENOG4105X2V	dna damage-inducible protein
VS_0671	ENOG4105EVZ	LysR family transcriptional regulator
VS_0673	ENOG4105DSY	exodeoxyribonuclease V, gamma
VS_0675	ENOG4107QKA	exodeoxyribonuclease V beta
VS_0676	ENOG4107QYX	exodeoxyribonuclease v alpha
VS_0678	ENOG4107QZM	n-acetylglutamate synthase
VS_0680	ENOG4105CA3	membrane-bound lytic murein transglycosylase
VS_0681	ENOG4105CUZ	uba thif-type nad fad binding protein
VS_0682	ENOG4105P9C	Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity)
VS_0683	ENOG4105C9B	Cysteine desulfurase
VS_0684	ENOG4108JZF	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity)
VS_0685	ENOG4105DRB	nucleoside-specific channel-forming protein
VS_0689	ENOG4108R5K	PPIases accelerate the folding of proteins (By similarity)
VS_0691	ENOG4105D8J	Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity)
VS_0692	ENOG4105M85	Bola protein
VS_0693	ENOG4105DWQ	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
VS_0694	ENOG4108J5C	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
VS_0695	ENOG4106I92	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
VS_0696	ENOG4105F5D	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
VS_0697	ENOG4108IUB	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
VS_0698	ENOG4105D26	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway (By similarity)
VS_0699	ENOG4105CJ2	(LipO)protein
VS_0701	ENOG4105BZU	Histidine kinase
VS_0702	ENOG4105CQ3	Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity)
VS_0703	ENOG4105C9U	ATP-dependent DNA helicase RecQ
VS_0704	ENOG4108UKH	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
VS_0706	ENOG4105C8J	)-transporter
VS_0707	ENOG4105C0G	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity)
VS_0708	ENOG4108BDP	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity)
VS_0709	ENOG4108Z43	UPF0250 protein
VS_0710	ENOG4105DZ1	carboxypeptidase
VS_0711	ENOG4105K6T	rare lipoprotein A
VS_0712	ENOG4105CNI	cell division protein FtsW
VS_0713	ENOG4105CJN	penicillin-binding protein
VS_0714	ENOG4108UXA	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity)
VS_0715	ENOG4105KEM	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity)
VS_0716	ENOG4105DJF	DNA polymerase III, delta' subunit
VS_0717	ENOG4108U2H	Rare lipoprotein B
VS_0718	ENOG4105C8T	Leucyl-tRNA synthetase
VS_0719	ENOG4107PAI	alpha helical protein
VS_0720	ENOG4105CE8	Transfers the fatty acyl group on membrane lipoproteins (By similarity)
VS_0721	ENOG4108JU5	Magnesium and cobalt efflux protein
VS_0722	ENOG4105KGE	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity)
VS_0723	ENOG4105C9A	Phoh family
VS_0724	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
VS_0725	ENOG4105EAK	ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family
VS_0726	ENOG4105HHQ	6-phosphogluconolactonase (EC 3.1.1.31)
VS_0746	ENOG4105C3G	gtp-binding protein
VS_0747	ENOG4108ZPD	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity)
VS_0748	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
VS_0749	ENOG4105CTR	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity)
VS_0751	ENOG4105C7E	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity)
VS_0752	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
VS_0753	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
VS_0754	ENOG4108YY7	Invasion gene expression up-regulator SirB
VS_0755	ENOG41063JG	Transcriptional regulator
VS_0756	ENOG4105CXR	Phospho-2-dehydro-3-deoxyoctonate aldolase
VS_0757	ENOG4105CGH	5'-nucleotidase
VS_0758	ENOG4108Z66	YbaK ebsC protein
VS_0759	ENOG4105FE9	pseudouridine synthase
VS_0760	ENOG4108DG9	Smr protein MutS2
VS_0765	ENOG4105E2D	ec 3.2.1.52
VS_0768	ENOG4105C59	p-type ATPase
VS_0770	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
VS_0771	ENOG4105C2D	reductase
VS_0773	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
VS_0779	ENOG4105C84	Histidine ammonia-lyase
VS_0780	ENOG4106N3V	dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83)
VS_0785	ENOG4105VNB	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
VS_0798	ENOG4105XZC	flagellar basal body P-ring biosynthesis protein FlgA
VS_0799	ENOG4107R88	Chemotaxis protein (CheV)
VS_0800	ENOG4105BZU	Histidine kinase
VS_0801	ENOG4105K88	Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity)
VS_0802	ENOG4108ZC9	flagellar basal-body rod protein flgc
VS_0803	ENOG4105W00	Flagellar hook capping protein
VS_0804	ENOG4105BZE	flagellar hook protein, FlgE
VS_0805	ENOG4108KPB	Flagellar basal-body rod protein FlgF
VS_0806	ENOG4105CGA	flagellar basal-body rod protein FlgG
VS_0807	ENOG4107W7W	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity)
VS_0808	ENOG4105D92	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity)
VS_0809	ENOG4108ZW7	flagellar rod assembly protein muramidase flgj
VS_0812	ENOG4105I03	Flagellin
VS_0813	ENOG4105I03	Flagellin
VS_0814	ENOG4105I03	Flagellin
VS_0815	ENOG41063QE	flagellar protein FlaG
VS_0816	ENOG4107BRV	flagellar capping protein
VS_0818	ENOG4105MQ3	flagellar protein FliS
VS_0819	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
VS_0820	ENOG4105BZU	Histidine kinase
VS_0821	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
VS_0822	ENOG4105VQ0	flagellar hook-basal body complex protein fliE
VS_0823	ENOG4105C1F	The M ring may be actively involved in energy transduction (By similarity)
VS_0824	ENOG4105CS3	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity)
VS_0826	ENOG4108JIR	Flagellum-specific ATP synthase
VS_0830	ENOG4105D24	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity)
VS_0831	ENOG4105DD5	Flagellar motor switch protein
VS_0832	ENOG4105VTB	flagellar biosynthesis protein fliO
VS_0833	ENOG4105CN7	Flagellar biosynthetic protein FliP
VS_0834	ENOG4105VS8	Flagellar biosynthetic protein fliq
VS_0835	ENOG4105D19	Role in flagellar biosynthesis (By similarity)
VS_0836	ENOG4105D00	flagellar biosynthetic protein flhB
VS_0837	ENOG4105D7B	Flagellar biosynthesis protein flha
VS_0838	ENOG4105FZW	flagellar biosynthesis regulator FlhF
VS_0839	ENOG4107R21	site-determining protein
VS_0840	ENOG4105DN4	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
VS_0841	ENOG4108VYJ	response regulator receiver protein
VS_0842	ENOG4108KCC	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity)
VS_0843	ENOG4105CBS	Chea signal transduction histidine kinase
VS_0845	ENOG4107QJE	Chromosome Partitioning Protein
VS_0847	ENOG4108V3W	Chemotaxis protein, CheW
VS_0849	ENOG4107EV4	once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity)
VS_0850	ENOG4105CA5	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity)
VS_0852	ENOG41060IM	Heme exporter protein
VS_0853	ENOG4105X3C	heme exporter protein
VS_0854	ENOG4108ZKK	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity)
VS_0855	ENOG4105DA4	cytochrome c-type biogenesis protein
VS_0856	ENOG4107QX9	Thiol disulfide interChange protein
VS_0857	ENOG4105KWW	Biogenesis protein
VS_0858	ENOG4105KWW	Biogenesis protein
VS_0859	ENOG410903C	(LipO)protein
VS_0860	ENOG4105CKF	membrane protein involved in aromatic hydrocarbon degradation
VS_0861	ENOG4105CKF	membrane protein involved in aromatic hydrocarbon degradation
VS_0864	ENOG4105CHU	acetyl-coa acetyltransferase
VS_0865	ENOG4105DYT	3-hydroxyacyl-CoA dehydrogenase
VS_0866	ENOG4107QXK	peptidase
VS_0867	ENOG4108BY2	phosphohistidine phosphatase
VS_0868	ENOG4108DG9	Smr protein MutS2
VS_0869	ENOG4105C76	Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity)
VS_0872	ENOG4105CNG	UPF0061 protein
VS_0873	ENOG4105DPZ	Two component transcriptional regulator (Winged helix family
VS_0874	ENOG4105E0F	Histidine kinase
VS_0876	ENOG4105EQ7	Binding-protein-dependent transport systems, inner membrane component
VS_0878	ENOG4108IJ9	(ABC) transporter
VS_0879	ENOG4105RX7	peptidase S8 and S53, subtilisin, kexin, sedolisin
VS_0880	ENOG4105C1N	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity)
VS_0881	ENOG4105VJP	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity)
VS_0882	ENOG4107QMS	site-determining protein
VS_0883	ENOG4105K7U	Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity)
VS_0884	ENOG4105VNG	YcgL domain-containing protein
VS_0885	ENOG4105CVE	Lytic murein transglycosylase
VS_0886	ENOG4105EJC	lysr family transcriptional regulator
VS_0887	ENOG4105D9N	nucleoside
VS_0889	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
VS_0892	ENOG4105D10	5-enolpyruvylshikimate-3-phosphate phospholyase
VS_0893	ENOG4105EN6	Membrane
VS_0894	ENOG4108BPE	-transporting atpase
VS_0895	ENOG4105MH2	YfcL protein
VS_0896	ENOG4105Q8W	reductase
VS_0897	ENOG4105CWG	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity)
VS_0898	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
VS_0900	ENOG4105CJ0	Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate (By similarity)
VS_0901	ENOG4105CM3	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity)
VS_0903	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
VS_0904	ENOG4107QTG	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity)
VS_0905	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
VS_0906	ENOG4108S3P	Sporulation domain protein
VS_0907	ENOG4105E96	Colicin v production protein
VS_0908	ENOG4105CBA	glutamine phosphoribosylpyrophosphate amidotransferase
VS_0909	ENOG4105EJC	lysr family transcriptional regulator
VS_0910	ENOG4105I93	response regulator
VS_0913	ENOG4105WD1	Membrane
VS_0914	ENOG4109003	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity)
VS_0915	ENOG4107QMP	dna polymerase iii subunits gamma and tau
VS_0917	ENOG4105KDX	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity)
VS_0918	ENOG4105F3K	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity)
VS_0919	ENOG4105D8C	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity)
VS_0922	ENOG4105KRS	Proteinase inhibitor
VS_0923	ENOG4108ZZ3	UPF0260 protein
VS_0924	ENOG4105G6Z	alkaline phosphatase
VS_0925	ENOG4105C94	Transporter
VS_0928	ENOG4105DHI	Methyltransferase
VS_0929	ENOG4107SDU	Methyl-accepting chemotaxis
VS_0931	ENOG4105DSB	aldose 1-epimerase
VS_0932	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
VS_0933	ENOG4105E0X	reductase
VS_0935	ENOG4105VUT	cytoplasmic protein
VS_0936	ENOG4105HDK	L-asparaginase
VS_0937	ENOG4105D07	Signal peptide peptidase, SppA
VS_0938	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
VS_0939	ENOG41069NU	Nitroreductase
VS_0940	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
VS_0942	ENOG4108RU0	short-chain dehydrogenase reductase
VS_0943	ENOG4105DGU	Histone deacetylase
VS_0945	ENOG4105KPV	Transcriptional regulator
VS_0949	ENOG4105E68	Sulfatase
VS_0950	ENOG4105PAN	UPF0352 protein
VS_0951	ENOG4106V8H	Nucleoid-associated protein
VS_0954	ENOG4105DFD	Na H antiporter
VS_0955	ENOG4105CM3	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity)
VS_0956	ENOG4105EYW	Ion transport protein
VS_0957	ENOG4105EZI	multiple antibiotic resistance (MarC)-related protein
VS_0958	ENOG4108EKI	Dehydrogenase
VS_0961	ENOG4105CK4	Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity)
VS_0962	ENOG4105M2J	Glutaredoxin
VS_0964	ENOG4105BZU	Histidine kinase
VS_0966	ENOG4105D3Y	Na H antiporter
VS_0967	ENOG4105DH5	Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity)
VS_0968	ENOG4105EIY	sodium-type flagellar protein motY
VS_0969	ENOG4106WH9	Protein of unknown function (DUF2753)
VS_0970	ENOG4108UYE	Lactoylglutathione lyase
VS_0971	ENOG4105CSM	endonuclease III
VS_0972	ENOG4105DZB	Electron transport complex
VS_0973	ENOG4108UQQ	Electron transport complex
VS_0974	ENOG4105D6A	Electron transport complex
VS_0977	ENOG4108R3D	Electron transport complex
VS_0978	ENOG4105DGN	Electron transport complex
VS_0980	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
VS_0982	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
VS_0984	ENOG4105CHW	UPF0052 protein
VS_0985	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
VS_0986	ENOG4108RIR	Molybdenum cofactor biosynthesis protein
VS_0987	ENOG4108YXW	Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
VS_0988	ENOG4105M00	molybdopterin converting factor, subunit 1
VS_0989	ENOG4108ZAF	Molybdopterin
VS_0990	ENOG4107QSI	ABC, transporter
VS_0991	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
VS_0992	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
VS_0993	ENOG4105C3U	ABC transporter
VS_0994	ENOG4108JQ7	(ABC) transporter
VS_0995	ENOG4105CHF	Glutathione S-transferase
VS_0996	ENOG4105BZU	Histidine kinase
VS_0997	ENOG4108DNC	Involved in acetate metabolism (By similarity)
VS_0998	ENOG4105C6H	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity)
VS_0999	ENOG4105PQ6	UPF0208 membrane protein
VS_1001	ENOG4105BZU	Histidine kinase
VS_1002	ENOG4105FBT	Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity)
VS_1003	ENOG4105X0D	Fimbrial protein
VS_1004	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
VS_1005	ENOG410635M	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity)
VS_1006	ENOG4105DKR	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity)
VS_1007	ENOG4105C05	Multifunctional regulator of fatty acid metabolism (By similarity)
VS_1009	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
VS_1010	ENOG4105D1F	ATP-binding protein
VS_1011	ENOG4105DBI	uridine monophosphokinase
VS_1012	ENOG4108GAE	asmA family
VS_1013	ENOG41068B1	Cob-I-yrinic acid a,c-diamide adenosyltransferase
VS_1014	ENOG4107ZCW	Low molecular weight phosphotyrosine protein phosphatase
VS_1015	ENOG4105CHH	sulfate transporter
VS_1016	ENOG4105C03	ribonuclease
VS_1017	ENOG4105EI2	Pseudouridine synthase
VS_1018	ENOG4108UHJ	MAF-like protein
VS_1019	ENOG4105FCQ	metal-binding, possibly nucleic acid-binding protein
VS_1020	ENOG4105VGS	50s ribosomal protein l32
VS_1021	ENOG4105C6B	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity)
VS_1023	ENOG4105CJF	Malonyl coA-acyl carrier protein transacylase
VS_1024	ENOG4105CHR	reductase
VS_1025	ENOG4105VNB	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
VS_1026	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
VS_1027	ENOG4105YAZ	4-amino-4-deoxychorismate lyase
VS_1028	ENOG4105HHA	aminodeoxychorismate lyase
VS_1029	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
VS_1030	ENOG4107QRG	dna polymerase iii
VS_1031	ENOG4105F8V	Hydrolase, tatD family
VS_1032	ENOG4105CI1	PTS System
VS_1034	ENOG4105C8J	)-transporter
VS_1036	ENOG4108NRW	Phospholipase, patatin family
VS_1037	ENOG4105CA9	Pyruvate kinase
VS_1038	ENOG4105DAG	ROK family
VS_1039	ENOG4107R88	Chemotaxis protein (CheV)
VS_1040	ENOG4105C0B	DNA polymerase III (alpha subunit)
VS_1042	ENOG4105C68	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)
VS_1043	ENOG4105UBK	short-chain dehydrogenase reductase
VS_1044	ENOG4105ERU	peptidase
VS_1045	ENOG4105ED1	spovr family
VS_1046	ENOG4106AKX	UPF0229 protein
VS_1047	ENOG4105CYN	Serine protein kinase
VS_1048	ENOG4105GNX	MltA-interacting MipA family protein
VS_1049	ENOG4105XWI	UPF0304 protein
VS_1050	ENOG4105F1A	Pyruvate formate-lyase
VS_1052	ENOG4105C6N	Formate acetyltransferase
VS_1054	ENOG4108JEH	abc transporter atp-binding protein
VS_1055	ENOG4105E89	ABC transporter
VS_1056	ENOG4105DSP	amino acid AbC transporter
VS_1057	ENOG4106YG3	ABC transporter
VS_1059	ENOG4105CGK	Exodeoxyribonuclease III
VS_1060	ENOG4105CUG	Oligopeptidase b
VS_1061	ENOG4105E5M	Multidrug resistance protein D
VS_1062	ENOG4105C8Q	Methyl-accepting chemotaxis
VS_1063	ENOG4105EZE	Cupin 4 family protein
VS_1064	ENOG4106428	Protein of unknown function (DUF2496)
VS_1067	ENOG4105DVT	helicase
VS_1069	ENOG4108R99	pseudouridine synthase
VS_1072	ENOG4105VEQ	Cold shock protein
VS_1073	ENOG4105KAE	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity)
VS_1074	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
VS_1075	ENOG4105K9U	however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)
VS_1077	ENOG4108R4Z	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity)
VS_1079	ENOG4105CMY	5-enolpyruvylshikimate-3-phosphate synthase
VS_1080	ENOG4105RKX	Protein of unknown function (DUF2498)
VS_1081	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
VS_1082	ENOG4107QQ4	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity)
VS_1083	ENOG4105CXW	Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity)
VS_1087	ENOG4105HP8	regulator of competence-specific genes
VS_1088	ENOG4105ETE	Transcriptional regulator (LacI family
VS_1089	ENOG4109039	Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor (By similarity)
VS_1091	ENOG4106WF9	DNA-binding transcriptional regulator TorR
VS_1092	ENOG4107S90	membrAne
VS_1093	ENOG4106371	Methyltransferase
VS_1094	ENOG4105GHU	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity (By similarity)
VS_1095	ENOG4105DAH	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity)
VS_1097	ENOG4105C8Q	Methyl-accepting chemotaxis
VS_1100	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
VS_1101	ENOG4105PFA	Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity)
VS_1102	ENOG4105DA6	Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity)
VS_1103	ENOG41081XQ	Conserved Protein
VS_1104	ENOG4105C9M	aspartyl-trna synthetase
VS_1105	ENOG4105NHU	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity)
VS_1106	ENOG4105C8Q	Methyl-accepting chemotaxis
VS_1107	ENOG4105KA4	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity)
VS_1108	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
VS_1109	ENOG4105C4M	(Ubiquinol oxidase) subunit I
VS_1110	ENOG4105CFY	cytochrome d ubiquinol oxidase, subunit ii
VS_1112	ENOG4107YD3	Thioesterase
VS_1113	ENOG4105E02	MotA TolQ exbB proton channel
VS_1114	ENOG4105M8F	Biopolymer transport protein exbD tolR
VS_1116	ENOG4107R6Y	Involved in the TonB-independent uptake of proteins (By similarity)
VS_1117	ENOG4105KCK	Peptidoglycan-associated lipoprotein
VS_1118	ENOG4105UFD	tol-pal system protein YbgF
VS_1119	ENOG4105D0I	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity)
VS_1121	ENOG4107RBR	Receptor
VS_1122	ENOG4105Q26	Siderophore-interacting protein
VS_1123	ENOG4105PEC	Iron-enterobactin transporter periplasmic binding protein
VS_1124	ENOG4105DQ5	transport system permease protein
VS_1125	ENOG4105TVJ	transport system, permease
VS_1126	ENOG4105E0A	ABC, transporter
VS_1129	ENOG4105BZU	Histidine kinase
VS_1130	ENOG4108RNS	Exports L-alanine (By similarity)
VS_1132	ENOG4106KR7	LysR family Transcriptional regulator
VS_1133	ENOG4105MWK	D-amino acid dehydrogenase, small subunit
VS_1137	ENOG4105ETX	regulatoR
VS_1139	ENOG4105SA9	Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity)
VS_1141	ENOG4105CCT	upf0313 protein
VS_1144	ENOG4105DZ2	Transcriptional regulator
VS_1145	ENOG4105DSS	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity)
VS_1147	ENOG4105K9H	YciI-like protein
VS_1148	ENOG4105NAU	thioesterase Superfamily protein
VS_1149	ENOG4107835	probably involved in intracellular septation (By similarity)
VS_1153	ENOG4105E89	ABC transporter
VS_1155	ENOG4105BZU	Histidine kinase
VS_1157	ENOG4105C8Q	Methyl-accepting chemotaxis
VS_1161	ENOG4108T9J	Cdp-alcohol phosphatidyltransferase
VS_1162	ENOG4108VGW	abc transporter atp-binding protein
VS_1163	ENOG4105CXZ	ABC transporter, permease
VS_1164	ENOG4105VNH	ABC transporter solute-binding protein
VS_1166	ENOG4105XZD	Fe-S protein
VS_1172	ENOG4105C1J	atp-dependent rna helicase
VS_1179	ENOG4108IJ7	Glycine betaine
VS_1180	ENOG4108HQS	Glycine betaine
VS_1181	ENOG4105GIJ	Glycine betaine
VS_1183	ENOG4108KB2	LysR family Transcriptional regulator
VS_1184	ENOG4108JJ8	(ABC) transporter
VS_1185	ENOG4108JJ9	ABC, transporter
VS_1186	ENOG4105C3M	thioredoxin reductase
VS_1192	ENOG4105C9B	Cysteine desulfurase
VS_1194	ENOG4105EXG	Transcriptional regulator
VS_1195	ENOG4105BZU	Histidine kinase
VS_1197	ENOG4105BZU	Histidine kinase
VS_1198	ENOG4105RA2	Membrane
VS_1199	ENOG4105C8P	)-transporter
VS_1201	ENOG4107GZ4	SanA protein
VS_1202	ENOG4107R1I	NAD-dependent malic enzyme
VS_1203	ENOG4105CQ7	ATP-dependent helicase
VS_1205	ENOG4105C8V	SAICAR synthetase
VS_1209	ENOG4105UYK	outer membrane protein a
VS_1212	ENOG4105CQB	FAD linked oxidase domain protein
VS_1216	ENOG4105C84	Histidine ammonia-lyase
VS_1217	ENOG4105CGP	Urocanate hydratase
VS_1218	ENOG41088SP	formiminoglutamate hydrolase
VS_1219	ENOG4105CI2	imidazolone-5-propionate hydrolase
VS_1221	ENOG4108N23	SpoOM-related protein
VS_1228	ENOG4105C22	threonyL-tRNA synthetase
VS_1229	ENOG4108UUX	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity)
VS_1230	ENOG41082NX	50s ribosomal protein l35
VS_1231	ENOG4108YZX	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity)
VS_1232	ENOG41060QA	UPF0267 protein
VS_1235	ENOG4105C5H	ABC transporter
VS_1236	ENOG4108RZE	Tetr family transcriptional regulator
VS_1237	ENOG4107RGH	Aldehyde dehydrogenase
VS_1238	ENOG4105DP5	Catalyzes the biosynthesis of agmatine from arginine (By similarity)
VS_1239	ENOG4105CYW	agmatinase
VS_1241	ENOG4105CK7	Sodium proline symporter
VS_1242	ENOG4108UHU	Aldolase
VS_1243	ENOG4107SS6	2-dehydro-3-deoxygluconokinase
VS_1244	ENOG4105M5J	Cupin 2, conserved barrel domain protein
VS_1246	ENOG4105EY3	heparinase II III family protein
VS_1247	ENOG4105EY3	heparinase II III family protein
VS_1248	ENOG4105CF3	3-Hydroxyisobutyrate dehydrogenase
VS_1250	ENOG4107EJG	GntR family transcriptional regulator
VS_1251	ENOG4107EJG	GntR family transcriptional regulator
VS_1252	ENOG41080XP	Cbs domain
VS_1253	ENOG4105DE5	Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity)
VS_1257	ENOG4107RJ1	sodium solute
VS_1259	ENOG4108F19	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity)
VS_1262	ENOG4105C0F	tryptophanase EC 4.1.99.1
VS_1274	ENOG4105C8P	)-transporter
VS_1275	ENOG4105BZU	Histidine kinase
VS_1276	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
VS_1282	ENOG4105DSS	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity)
VS_1284	ENOG4105HF0	Membrane
VS_1289	ENOG4105CTD	carboxy-peptidase
VS_1290	ENOG4105N14	lysine exporter protein LysE YggA
VS_1291	ENOG4105BZG	amino acid carrier protein
VS_1296	ENOG4105BZG	amino acid carrier protein
VS_1299	ENOG4107KET	secretion protein, HlyD family
VS_1302	ENOG4105CEQ	signal transduction histidine kinase regulating citrate malate metabolism
VS_1303	ENOG4108V9W	transcriptional regulatory protein
VS_1304	ENOG4105D8W	glucose-6-phosphate 1-dehydrogenase
VS_1305	ENOG4108Q79	6-phosphogluconolactonase (EC 3.1.1.31)
VS_1306	ENOG4105C7Q	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity)
VS_1307	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
VS_1308	ENOG4105VYA	Uncharacterized conserved protein (DUF2132)
VS_1315	ENOG4105BZU	Histidine kinase
VS_1316	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
VS_1317	ENOG4105D9P	serine threonine protein kinase
VS_1326	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
VS_1337	ENOG4105CS6	Rhs element vgr protein
VS_1341	ENOG4108ESY	Metal dependent phosphohydrolase
VS_1343	ENOG4105CR4	methylisocitrate lyase
VS_1344	ENOG4105BZN	citrate synthase
VS_1345	ENOG4108I0Z	Aconitate hydratase
VS_1346	ENOG4105C7F	AcnD-accessory protein PrpF
VS_1347	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
VS_1352	ENOG410667J	hydrolase
VS_1353	ENOG4105EIZ	Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity)
VS_1354	ENOG4105FD2	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity)
VS_1355	ENOG4105FD2	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity)
VS_1362	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
VS_1376	ENOG4107SCJ	type I restriction enzyme EcoKI subunit R
VS_1378	ENOG4105CVR	type I restriction-modification system
VS_1381	ENOG4105FBQ	ATPase associated with various cellular activities aaa_5
VS_1384	ENOG4108YUH	
VS_1390	ENOG4105BZU	Histidine kinase
VS_1395	ENOG4105DR4	Methyltransferase
VS_1396	ENOG4105C8Q	Methyl-accepting chemotaxis
VS_1397	ENOG4105VSY	K01512 acylphosphatase EC 3.6.1.7
VS_1398	ENOG4108Z0T	Part of a sulfur-relay system (By similarity)
VS_1399	ENOG4108MN8	Membrane
VS_1400	ENOG4105CDA	abc transporter atp-binding protein
VS_1401	ENOG4105DRP	amino acid AbC transporter
VS_1402	ENOG4105EZ7	amino acid ABC transporter
VS_1403	ENOG4107QXX	ABC transporter
VS_1405	ENOG4108VPT	UPF0234 protein
VS_1406	ENOG4105E99	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity)
VS_1407	ENOG4108HRN	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity)
VS_1410	ENOG4105QNR	S1 RNA binding domain protein
VS_1411	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
VS_1412	ENOG4105DY2	Paraquat-inducible protein b
VS_1413	ENOG4105H2K	paraquat-inducible protein a
VS_1414	ENOG4105BZ1	(ABC) transporter
VS_1416	ENOG41073DY	may be a structural element that influences the osmotic activation of ProP at a post-translational level (By similarity)
VS_1417	ENOG4105CN1	protease
VS_1419	ENOG4105CD8	aminopeptidase N
VS_1421	ENOG4105C7I	Dehydrogenase
VS_1422	ENOG4107QYT	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity)
VS_1423	ENOG4108T7E	Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity)
VS_1424	ENOG4105C4H	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity)
VS_1426	ENOG4105C5H	ABC transporter
VS_1429	ENOG4108RKI	Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity)
VS_1430	ENOG4105DAN	ATP-dependent protease
VS_1431	ENOG4108R9Q	Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle. Prevents early segregation of duplicated Ter macrodomains during cell division. Binds specifically to matS, which is a 13 bp signature motif repeated within the Ter macrodomain (By similarity)
VS_1456	ENOG4105BZU	Histidine kinase
VS_1459	ENOG4105EUH	cytochrome C oxidase, cbb3-type, subunit i
VS_1462	ENOG4105D6P	C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex (By similarity)
VS_1464	ENOG4105C59	p-type ATPase
VS_1467	ENOG4105DS0	Transcriptional regulator, Crp Fnr family
VS_1468	ENOG4105Q9Y	Universal stress protein
VS_1469	ENOG4105CB3	Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity)
VS_1474	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
VS_1475	ENOG4105F38	ABC transporter, permease
VS_1476	ENOG4105D38	putrescine abc transporter
VS_1477	ENOG4107RUE	extracellular solute-binding protein family 1
VS_1478	ENOG4107RUE	extracellular solute-binding protein family 1
VS_1480	ENOG4105NDF	NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity)
VS_1484	ENOG4105QAX	Iron-sulfur
VS_1485	ENOG4107QIW	Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity)
VS_1487	ENOG4108SBI	Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor (By similarity)
VS_1492	ENOG4107H9G	Necessary for formate dehydrogenase activity (By similarity)
VS_1493	ENOG4105C5H	ABC transporter
VS_1494	ENOG4105C5H	ABC transporter
VS_1497	ENOG4105BZU	Histidine kinase
VS_1498	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
VS_1500	ENOG4107A5B	Binding-protein-dependent transport systems, inner membrane component
VS_1501	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
VS_1502	ENOG4105C6R	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity)
VS_1503	ENOG4105CVM	Molybdenum cofactor synthesis domain protein
VS_1504	ENOG4105BZU	Histidine kinase
VS_1507	ENOG4105EZX	Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P (By similarity)
VS_1508	ENOG4106IUH	DTW domain containing protein
VS_1510	ENOG4105C8Q	Methyl-accepting chemotaxis
VS_1511	ENOG4107TT5	NLP P60 protein
VS_1513	ENOG4105FGM	Fructosamine kinase
VS_1516	ENOG4108R6K	riboflavin synthase, subunit alpha
VS_1520	ENOG4105UYK	outer membrane protein a
VS_1524	ENOG4108HQS	Glycine betaine
VS_1525	ENOG4108IJ7	Glycine betaine
VS_1527	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
VS_1528	ENOG4107T8Q	Glycosyl transferase (Group 1
VS_1533	ENOG4107R5M	Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity)
VS_1534	ENOG4105CND	Glycosyl transferase, family 2
VS_1536	ENOG4105C8Q	Methyl-accepting chemotaxis
VS_1537	ENOG4105HEI	LysR family (Transcriptional regulator
VS_1541	ENOG4105ENJ	RND efflux system, outer membrane lipoprotein
VS_1550	ENOG4105MN5	HAD-superfamily hydrolase subfamily IA variant 3
VS_1552	ENOG4108HWB	Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity)
VS_1558	ENOG4105C4K	Nad synthetase
VS_1561	ENOG4105DMR	ABC, transporter
VS_1562	ENOG4105GBT	ABC transporter
VS_1563	ENOG4106PMH	Extracellular solute-binding protein family 3
VS_1564	ENOG4105E5Z	arginine transporter ATP-binding subunit
VS_1567	ENOG4105CFP	Peptidase U32
VS_1570	ENOG4105D6U	Sodium Glutamate Symporter
VS_1577	ENOG4105CYX	Short-chain dehydrogenase reductase Sdr
VS_1579	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
VS_1580	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
VS_1584	ENOG4108ZI4	Glyoxalase Bleomycin resistance protein (Dioxygenase
VS_1590	ENOG4108Z4K	mutator MutT protein
VS_1593	ENOG4105JSC	dimethylmenaquinone methyltransferase
VS_1601	ENOG4105I08	Pseudouridine synthase
VS_1604	ENOG4105M6F	mutator MutT protein
VS_1609	ENOG4108M3J	Dehydrogenase
VS_1611	ENOG4106MZZ	glycerophosphoryl diester phosphodiesterase
VS_1612	ENOG4105CXY	transporter
VS_1618	ENOG4108M6U	Universal stress protein A
VS_1619	ENOG4105CVP	deoxyribo-dipyrimidine photolyase
VS_1620	ENOG4105EXX	Deoxyribodipyrimidine photolyase-related protein
VS_1625	ENOG4105EYH	Exonuclease
VS_1626	ENOG4107RH8	nuclease SbcCD subunit D
VS_1630	ENOG4105I4A	GCN5-related N-acetyltransferase
VS_1631	ENOG4105BZU	Histidine kinase
VS_1633	ENOG4105D05	Receptor
VS_1636	ENOG4108N3W	hemolysin secretion protein
VS_1638	ENOG4105PGM	cation diffusion facilitator family transporter
VS_1639	ENOG4105ENH	Sulfatase
VS_1640	ENOG41064T2	transcriptional regulator, lysR family
VS_1642	ENOG4105C91	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
VS_1648	ENOG4105BZK	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity)
VS_1649	ENOG4105NI8	Cytosine-specific methyltransferase
VS_1650	ENOG41088T4	Helicase IV
VS_1653	ENOG4108UMW	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
VS_1655	ENOG4108YGG	dna repair protein
VS_1669	ENOG4105DFP	Integrase
VS_1673	ENOG4105BZU	Histidine kinase
VS_1674	ENOG4105D42	Cleaves the N-terminal amino acid of tripeptides (By similarity)
VS_1677	ENOG4105CVG	Homoserine O-transsuccinylase
VS_1678	ENOG41090FY	type IV pilus biogenesis stability protein PilW
VS_1679	ENOG4105EBA	Specifically methylates the adenine in position 1618 of 23S rRNA (By similarity)
VS_1680	ENOG4108VKG	metal-dependent hydrolase
VS_1683	ENOG4105D94	Major Facilitator Superfamily
VS_1687	ENOG4105WCN	acetyltransferase
VS_1689	ENOG4105CFY	cytochrome d ubiquinol oxidase, subunit ii
VS_1690	ENOG4105C4M	(Ubiquinol oxidase) subunit I
VS_1691	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
VS_1695	ENOG41080WI	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system (By similarity)
VS_1696	ENOG4108IU2	vtamin B12-transporter permease
VS_1697	ENOG4107UI5	Transforms N(2)-succinylglutamate into succinate and glutamate (By similarity)
VS_1700	ENOG4108YZT	Adenosylcobinamide kinase
VS_1701	ENOG4108UHF	Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity)
VS_1702	ENOG4105CUP	Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity)
VS_1703	ENOG4107XWI	flavin reductase domain protein, FMN-binding
VS_1704	ENOG4105K4T	epimerase
VS_1705	ENOG4108ETY	sodium dicarboxylate symporter
VS_1707	ENOG4105IUQ	nucleoprotein polynucleotide-associated enzyme
VS_1713	ENOG4105CJB	Exodeoxyribonuclease I
VS_1714	ENOG4105VAW	lrga family
VS_1715	ENOG41067MG	lrgb family
VS_1716	ENOG4107T42	This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis (By similarity)
VS_1717	ENOG4108HH9	Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR
VS_1718	ENOG4105FQ6	thiopurine methyltransferase
VS_1721	ENOG4108ZUF	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
VS_1723	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
VS_1724	ENOG4107KBT	8-Amino-7-oxononanoate synthase
VS_1725	ENOG4108MGY	Histidine kinase
VS_1726	ENOG4105E2B	Taurine dioxygenase
VS_1728	ENOG4105C8Q	Methyl-accepting chemotaxis
VS_1735	ENOG4105K70	DNA-binding protein
VS_1739	ENOG4105VYW	UPF0251 protein
VS_1743	ENOG4108IQK	o-acetylhomoserine
VS_1744	ENOG4108YXU	transcriptional regulator AsnC family
VS_1748	ENOG4105K8U	2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
VS_1749	ENOG4105KKP	D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase
VS_1750	ENOG4105EUJ	GTP cyclohydrolase i
VS_1751	ENOG410642E	Short chain dehydrogenase
VS_1761	ENOG4105D3C	The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity)
VS_1765	ENOG4105C6A	phenylalanyl-tRNA synthetase (beta subunit)
VS_1766	ENOG4105CSS	phenylalanyl-tRNA synthetase (alpha subunit)
VS_1775	ENOG4105CQ7	ATP-dependent helicase
VS_1781	ENOG4108SGD	regulatory protein
VS_1785	ENOG4105BZU	Histidine kinase
VS_1787	ENOG4105CFG	Acts as a chaperone (By similarity)
VS_1788	ENOG4105CFG	Acts as a chaperone (By similarity)
VS_1792	ENOG4105D9U	N-acetyltransferase
VS_1793	ENOG4108JU8	Transcriptional regulator
VS_1794	ENOG4106K28	UPF0283 membrane protein
VS_1795	ENOG4105CM6	amino acid regulated cytosolic protein
VS_1798	ENOG4105CRQ	synthase (Component I)
VS_1800	ENOG4105BZU	Histidine kinase
VS_1802	ENOG4105P8F	nudix hydrolase
VS_1803	ENOG4105C44	Serine transporter
VS_1804	ENOG4105EJQ	L-serine dehydratase
VS_1805	ENOG4105E0U	tyrosine-specific transport protein
VS_1806	ENOG4107ZIF	6-carboxy-5,6,7,8-tetrahydropterin synthase
VS_1807	ENOG4108N3W	hemolysin secretion protein
VS_1808	ENOG4105CHH	sulfate transporter
VS_1809	ENOG4105C5S	asparaginyl-tRNA synthetase
VS_1814	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
VS_1816	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
VS_1819	ENOG4105CGF	Aromatic amino acid aminotransferase
VS_1822	ENOG4105DE5	Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity)
VS_1823	ENOG4108RPX	mosc domain containing protein
VS_1824	ENOG4107QM1	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity)
VS_1826	ENOG4105BZU	Histidine kinase
VS_1827	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
VS_1831	ENOG4105DWU	Membrane
VS_1833	ENOG4105DY8	decarboxylase
VS_1834	ENOG4106KNT	transcriptional regulator
VS_1835	ENOG4105C0A	alcohol dehydrogenase
VS_1836	ENOG41090BQ	Glutaredoxin
VS_1837	ENOG4105D0C	transport protein
VS_1839	ENOG4105RKW	reductase (By
VS_1840	ENOG4107QPN	acyl-Coa dehydrogenase
VS_1841	ENOG41067SE	Tetr family transcriptional regulator
VS_1845	ENOG4105DRC	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity)
VS_1850	ENOG4105CGD	Nad-dependent epimerase dehydratase
VS_1852	ENOG4105C2C	drug resistance transporter, Bcr CflA
VS_1853	ENOG4105I08	Pseudouridine synthase
VS_1854	ENOG4105CFI	type iii restriction protein res subunit
VS_1855	ENOG4105BZU	Histidine kinase
VS_1859	ENOG4105KHU	inner membrane protein YohD
VS_1861	ENOG4105KW6	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity)
VS_1876	ENOG4105M6F	mutator MutT protein
VS_1886	ENOG41067XF	inhibitor
VS_1891	ENOG4105JZI	cytochrome P450
VS_1898	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
VS_1899	ENOG4105G3E	Probably involved in ribonucleotide reductase function (By similarity)
VS_1901	ENOG4108Z4V	iron-sulfur cluster assembly
VS_1902	ENOG4105DIW	FeS assembly protein SUFB
VS_1903	ENOG4105C3K	feS assembly ATPase SufC
VS_1904	ENOG4105JRK	feS assembly protein SufD
VS_1905	ENOG4105C9B	Cysteine desulfurase
VS_1906	ENOG4105P9C	Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity)
VS_1907	ENOG4105C8Q	Methyl-accepting chemotaxis
VS_1908	ENOG4105C94	Transporter
VS_1909	ENOG4105C94	Transporter
VS_1912	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
VS_1914	ENOG4105CH5	extracellular solute-binding protein, family 7
VS_1917	ENOG4105C5X	domain protein
VS_1918	ENOG4105EAQ	(twin-arginine translocation) pathway signal
VS_1919	ENOG4105DIT	ErfK YbiS YcfS YnhG family protein
VS_1924	ENOG4107T1C	Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity)
VS_1926	ENOG4108DMF	Cytochrome C biogenesis protein
VS_1927	ENOG4107QX9	Thiol disulfide interChange protein
VS_1928	ENOG4105DA4	cytochrome c-type biogenesis protein
VS_1930	ENOG4105DVI	reductase, NrfD
VS_1931	ENOG4105D3S	4Fe-4S Ferredoxin, iron-sulfur binding domain protein
VS_1932	ENOG4105JJ8	Cytochrome c nitrite reductase, pentaheme subunit
VS_1933	ENOG4105EAU	Plays a role in nitrite reduction (By similarity)
VS_1934	ENOG4105K8Z	Phage shock protein
VS_1936	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
VS_1937	ENOG4108HWB	Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity)
VS_1939	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
VS_1940	ENOG4105E05	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
VS_1945	ENOG4105D3D	Catalyzes the decarboxylation of carboxynorspermidine and carboxyspermidine (By similarity)
VS_1954	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
VS_1955	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
VS_1956	ENOG4105WH1	Two component transcriptional regulator luxr family
VS_1957	ENOG4105CQ2	DNA polymerase
VS_1960	ENOG4108W5H	UPF0263 protein
VS_1962	ENOG4105FE9	pseudouridine synthase
VS_1963	ENOG4107RTD	sua5 ycio yrdc ywlc family protein
VS_1964	ENOG4105DB7	PHP domain protein
VS_1966	ENOG4105CRQ	synthase (Component I)
VS_1967	ENOG4105DDQ	anthranilate synthase
VS_1968	ENOG4108I0Q	anthranilate phosphoribosyltransferase
VS_1969	ENOG4105DK0	Indole-3-glycerol phosphate synthase
VS_1970	ENOG4105CG0	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
VS_1971	ENOG4105F6H	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity)
VS_1972	ENOG4107QX8	SPFH domain, Band 7 family protein
VS_1974	ENOG4105CK2	sodium dicarboxylate symporter
VS_1977	ENOG4105C4H	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity)
VS_1978	ENOG4108W1A	pseudouridine synthase
VS_1980	ENOG4105C8J	)-transporter
VS_1982	ENOG4105C28	cystathionine
VS_1985	ENOG4108R3E	Dna-3-methyladenine glycosylase i
VS_1988	ENOG4105C1P	efflux transporter, rnd family, mfp subunit
VS_1989	ENOG4105FM1	phage shock protein C
VS_1990	ENOG4105YYT	phage shock protein B
VS_1991	ENOG41087YS	Phage shock protein A
VS_1992	ENOG4105E51	psp operon transcriptional activator
VS_1993	ENOG4108HIY	periplasmic
VS_1994	ENOG4108I5W	peptide transport system, permease protein
VS_1995	ENOG4108EU3	peptide transport system, permease
VS_1996	ENOG4108JQ3	Peptide ABC transporter ATP-binding protein
VS_1997	ENOG4108JQ2	peptide transport system atp-binding protein
VS_2001	ENOG4105E2M	Manganese-dependent inorganic pyrophosphatase
VS_2003	ENOG4108J2R	molybdopterin oxidoreductase
VS_2008	ENOG4105TMB	Formate nitrite transporter
VS_2013	ENOG4107104	thymidine kinase
VS_2014	ENOG4105C8N	cysteinyl-tRNA synthetase
VS_2015	ENOG4108R5K	PPIases accelerate the folding of proteins (By similarity)
VS_2016	ENOG4105F10	Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity)
VS_2017	ENOG4105D58	Diguanylate phosphodiesterase
VS_2018	ENOG4105K5B	UPF0225 protein
VS_2019	ENOG4105K8F	Phosphoribosyl-amp cyclohydrolase
VS_2020	ENOG4105C0S	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity)
VS_2022	ENOG4108UJE	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity)
VS_2023	ENOG4105ECC	imidazole-glycerol-phosphate dehydratase
VS_2024	ENOG4105CIH	Imidazole acetol-phosphate transaminase
VS_2025	ENOG4105CEK	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity)
VS_2026	ENOG4105E21	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity)
VS_2027	ENOG4107S6Z	Na H antiporter
VS_2030	ENOG4107RE1	Inosine-guanosine kinase
VS_2033	ENOG41075W9	High frequency lysogenization protein HflD homolog
VS_2034	ENOG4107QTF	adenylosuccinate lyase
VS_2035	ENOG4105D0M	Protease HtpX homolog
VS_2037	ENOG4105EWW	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity)
VS_2039	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
VS_2040	ENOG4105CZF	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity)
VS_2041	ENOG4108JPX	Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity)
VS_2043	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
VS_2044	ENOG4105D1H	recombination factor protein RarA
VS_2045	ENOG4107Y7W	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity)
VS_2046	ENOG4105CNU	cell division protein FtsK
VS_2047	ENOG4105EW9	transcriptional regulator AsnC family
VS_2048	ENOG4105DCF	alanine dehydrogenase
VS_2050	ENOG4107R11	Transcriptional regulator
VS_2052	ENOG4105FR9	TRNA-(Ms 2 io 6 A)-hydroxylase
VS_2053	ENOG4106EG9	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity)
VS_2054	ENOG4105CFV	Tetratricopeptide repeat protein
VS_2055	ENOG4105Q4A	inner membrane protein yciS
VS_2056	ENOG41080YA	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
VS_2057	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
VS_2058	ENOG4105CAT	Cytidine monophosphate kinase
VS_2059	ENOG4105CET	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity)
VS_2060	ENOG4105W49	UPF0434 protein
VS_2061	ENOG4105CHD	Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity)
VS_2062	ENOG4105BZ1	(ABC) transporter
VS_2063	ENOG4108EQH	DNA internalization-related competence protein ComEC Rec2
VS_2065	ENOG4105D60	lipoprotein releasing system transmembrane protein
VS_2066	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
VS_2067	ENOG4105D60	lipoprotein releasing system transmembrane protein
VS_2069	ENOG4108JA2	transcriptioN-repair coupling factor
VS_2072	ENOG4105CEP	NADH dehydrogenase
VS_2073	ENOG4105D0Y	UPF0227 protein
VS_2079	ENOG4105K59	histidine triad (HIT) protein
VS_2080	ENOG4108NVR	Methyl-accepting chemotaxis
VS_2082	ENOG4107SXA	Phosphorylase
VS_2085	ENOG4105W87	Cbs domain
VS_2090	ENOG4108Z33	Thiol disulfide Interchange Protein
VS_2092	ENOG4108R5K	PPIases accelerate the folding of proteins (By similarity)
VS_2095	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
VS_2096	ENOG4108UYE	Lactoylglutathione lyase
VS_2101	ENOG4105EUZ	Beta-lactamase domain protein
VS_2103	ENOG4105BZS	acriflavin resistance protein
VS_2106	ENOG4105DDW	LysR family Transcriptional regulator
VS_2107	ENOG4105N0V	mono-oxygenase ydhR
VS_2109	ENOG4105QNF	Outer membrane lipoprotein
VS_2110	ENOG4105EFZ	amidohydrolase
VS_2112	ENOG4105E0A	ABC, transporter
VS_2113	ENOG4105J76	Periplasmic binding protein
VS_2114	ENOG4105S6R	Iron-hydroxamate transporter permease subunit
VS_2119	ENOG4105N6Y	Thioredoxin
VS_2120	ENOG4105CSG	Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity)
VS_2124	ENOG4105K6T	rare lipoprotein A
VS_2126	ENOG4105D3R	alkyl hydroperoxide reductase
VS_2127	ENOG4108JU3	Alkyl hydroperoxide reductase
VS_2129	ENOG4108ZRZ	Transcriptional regulator (AsnC family)
VS_2133	ENOG4108Z4X	TRANSCRIPTIONal
VS_2135	ENOG4105EJC	lysr family transcriptional regulator
VS_2138	ENOG4105CBC	glutamate synthase
VS_2145	ENOG4105CNK	Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity)
VS_2152	ENOG4107TYR	Glycosyl Transferase
VS_2153	ENOG4108B1Q	Ribonuclease
VS_2161	ENOG41090JN	Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity)
VS_2165	ENOG4108MNP	Glycoprotein polysaccharide metabolism
VS_2166	ENOG4105C29	acyl-CoA thioesterase
VS_2168	ENOG4108XM1	transcriptional regulator AsnC family
VS_2171	ENOG4105BZS	acriflavin resistance protein
VS_2183	ENOG4105HMI	Membrane
VS_2186	ENOG4105CI1	PTS System
VS_2187	ENOG4105CEY	Amp-dependent synthetase and ligase
VS_2188	ENOG4105DNI	Converts SHCHC to OSB (By similarity)
VS_2189	ENOG4108IPT	Naphthoate synthase
VS_2190	ENOG4107J5P	Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity)
VS_2191	ENOG4105C4A	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity)
VS_2192	ENOG4105E4F	Isochorismate synthase
VS_2193	ENOG4105CHM	Aminotransferase
VS_2195	ENOG4105DK2	UPF0207 protein
VS_2196	ENOG4105C4Q	deoxyguanosinetriphosphate triphosphohydrolase-like protein
VS_2199	ENOG41083P1	competence protein ComEA helix-hairpin-helix repeat protein
VS_2200	ENOG4105EIN	peptidylprolyl cis-trans isomerase
VS_2201	ENOG4105K70	DNA-binding protein
VS_2203	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
VS_2204	ENOG4105CHN	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
VS_2205	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
VS_2206	ENOG4105DEA	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation
VS_2207	ENOG4105CQZ	Histidine kinase
VS_2210	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
VS_2211	ENOG410835K	Tripartite ATP-Independent Periplasmic transporter DctQ
VS_2212	ENOG4105DR6	Trap dicarboxylate transporter, dctp subunit
VS_2215	ENOG4107EEY	synthase
VS_2218	ENOG4107QKG	PfaD family
VS_2219	ENOG4105ZIE	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity)
VS_2220	ENOG4105CEY	Amp-dependent synthetase and ligase
VS_2221	ENOG4105D3C	The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity)
VS_2225	ENOG41072GX	Peptidase M22 Glycoprotease
VS_2226	ENOG4105DVT	helicase
VS_2228	ENOG4105CIY	formyltetrahydrofolate deformylase
VS_2229	ENOG4106ZCM	YecM protein
VS_2230	ENOG4105C75	arginyL-tRNA synthetase
VS_2234	ENOG4105XFK	Ferrous iron transport protein A
VS_2237	ENOG4105NXV	High-affinity zinc uptake system protein
VS_2238	ENOG4105FDK	ABC transporter
VS_2239	ENOG4105FAV	ABC, transporter
VS_2240	ENOG4105CH8	Succinyl-CoA ligase ADP-forming subunit alpha
VS_2241	ENOG4105CMV	Succinyl-CoA synthetase subunit beta
VS_2242	ENOG4105C7S	Dehydrogenase
VS_2243	ENOG4105C7P	2-oxoglutarate dehydrogenase, E1
VS_2244	ENOG4105E33	succinate dehydrogenase
VS_2246	ENOG4105C00	Succinate dehydrogenase (Flavoprotein subunit)
VS_2247	ENOG4105N1I	succinate dehydrogenase, hydrophobic membrane anchor protein
VS_2248	ENOG4108UTY	succinate dehydrogenase, cytochrome b556 subunit
VS_2249	ENOG4105BZN	citrate synthase
VS_2250	ENOG4107QNR	UPF0135 protein
VS_2252	ENOG4107QIX	Phosphoglucomutase (EC 5.4.2.2
VS_2253	ENOG4107CDU	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity)
VS_2254	ENOG4105EV9	Alpha Beta Hydrolase
VS_2256	ENOG4105MHQ	Low-potential electron donor to a number of redox enzymes (By similarity)
VS_2258	ENOG41090R7	Ferric uptake
VS_2259	ENOG4105CX6	glutaminyL-tRNA synthetase
VS_2260	ENOG4105CI1	PTS System
VS_2261	ENOG4105CE4	GlcNAc 6-P deacetylase
VS_2262	ENOG4105E2R	ROK family
VS_2263	ENOG4105CKD	glutathione-regulated potassium-efflux system protein
VS_2264	ENOG4105CAQ	asparagine synthetase
VS_2265	ENOG4105MDZ	Transcriptional activator rfaH
VS_2266	ENOG4105DUX	Transporter
VS_2267	ENOG4105CFX	Catalyzes the ferrous insertion into protoporphyrin IX (By similarity)
VS_2268	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
VS_2269	ENOG4105CJX	Molecular chaperone. Has ATPase activity (By similarity)
VS_2270	ENOG4108DQ1	activator toxR
VS_2273	ENOG4108RE9	Phosphodiesterase
VS_2278	ENOG4105ECP	epimerase
VS_2279	ENOG4105E1F	short-chain dehydrogenase reductase
VS_2280	ENOG4107QR8	Thioredoxin
VS_2281	ENOG4107QX8	SPFH domain, Band 7 family protein
VS_2283	ENOG4108Z6Z	Transcriptional regulator
VS_2285	ENOG41081QG	Porin Gram-negative type
VS_2286	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
VS_2288	ENOG4105EXN	Sulfate transport protein CysZ
VS_2289	ENOG4105C6T	cysteine synthase
VS_2290	ENOG4105KZ7	phosphocarrier protein hpr
VS_2292	ENOG4105C5Y	PTS System
VS_2293	ENOG4105I03	Flagellin
VS_2294	ENOG4105I03	Flagellin
VS_2295	ENOG4105EZR	dyp-type peroxidase family protein
VS_2296	ENOG4105QZU	Inner membrane protein YfeZ
VS_2300	ENOG4105KUZ	arsenate reductase
VS_2301	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
VS_2304	ENOG4107EG0	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity)
VS_2307	ENOG4108YXY	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
VS_2311	ENOG4105ERG	peptidase m48, ste24p
VS_2312	ENOG4105K89	arsenate reductase
VS_2313	ENOG4105CS1	NAD(P)H quinone oxidoreductase
VS_2316	ENOG4105C2W	permease
VS_2317	ENOG4105CZ5	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity)
VS_2318	ENOG4105CXB	phosphoribosylaminoimidazole synthetase
VS_2319	ENOG4108V3E	phosphoribosylglycinamide formyltransferase
VS_2320	ENOG4105E7A	Glutamine amidotransferase
VS_2321	ENOG4105F55	Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity)
VS_2322	ENOG4107QPN	acyl-Coa dehydrogenase
VS_2324	ENOG4107RZZ	dna polymerase iii epsilon subunit
VS_2325	ENOG4108UMW	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
VS_2328	ENOG4105D1A	Methyltransferase
VS_2329	ENOG4108RW0	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity)
VS_2330	ENOG4105E9H	Lytic Murein transglycosylase
VS_2332	ENOG4107NA1	Endonuclease Exonuclease phosphatase
VS_2333	ENOG4108YZA	Nitrogen regulatory protein pii
VS_2334	ENOG4105N7H	Cytochrome
VS_2335	ENOG4105D3U	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity)
VS_2336	ENOG4107QM9	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity)
VS_2337	ENOG4105C0B	DNA polymerase III (alpha subunit)
VS_2338	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
VS_2340	ENOG4105DAF	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
VS_2341	ENOG4108YXN	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity)
VS_2342	ENOG4105D7M	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
VS_2343	ENOG4108RFI	Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity)
VS_2345	ENOG4105DZP	Membrane-associated zinc metalloprotease
VS_2346	ENOG4105CEA	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity)
VS_2348	ENOG4105KNE	Phosphatidate cytidylyltransferase
VS_2349	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
VS_2351	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
VS_2352	ENOG4105CU7	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity)
VS_2353	ENOG4105CE9	30S ribosomal protein S2
VS_2354	ENOG4105CA1	Removes the N-terminal methionine from nascent proteins (By similarity)
VS_2355	ENOG4105E1P	Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity)
VS_2356	ENOG4108T8E	UPF0325 protein
VS_2357	ENOG4105DR9	pseudouridine synthase
VS_2358	ENOG4105WP7	tRNA pseudouridine synthase C
VS_2364	ENOG4108UPT	UPF0178 protein
VS_2365	ENOG4105CFC	Transporter
VS_2366	ENOG4105NRA	50s ribosomal protein l31 type b
VS_2367	ENOG4108R96	Methyltransferase, YaeB family
VS_2368	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
VS_2370	ENOG4105W1I	UPF0253 protein
VS_2373	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
VS_2374	ENOG4108JYZ	YitT family
VS_2377	ENOG4105CG3	alpha amylase, catalytic region
VS_2378	ENOG4105C5Y	PTS System
VS_2379	ENOG4105D4X	repressor
VS_2381	ENOG4108ZI0	d,d-heptose 1,7-bisphosphate phosphatase
VS_2383	ENOG4108UMI	ABC transporter, permease
VS_2384	ENOG4105D01	(LipO)protein
VS_2388	ENOG4105EXF	Zn-ribbon-containing, possibly nucleic-acid-binding protein
VS_2389	ENOG4108T6E	Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function (By similarity)
VS_2390	ENOG4107R1K	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity)
VS_2392	ENOG4105BZU	Histidine kinase
VS_2393	ENOG4105EWT	decarboxylase family
VS_2394	ENOG4105CIQ	May have a role in processing of nucleic acids. It is probably not an exonuclease
VS_2396	ENOG4105EZ6	Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA (By similarity)
VS_2399	ENOG4105ETT	transcriptional Regulator, LysR family
VS_2401	ENOG4105D8I	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity)
VS_2402	ENOG4106VK6	Flagellar motor protein
VS_2403	ENOG4105E14	MotA TolQ exbB proton channel
VS_2404	ENOG41067QG	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
VS_2405	ENOG4105CTB	Polyprenyl synthetase
VS_2406	ENOG4105C2V	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity)
VS_2407	ENOG4108ZAI	phosphatidylglycerophosphatase a
VS_2408	ENOG4105CG2	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity)
VS_2409	ENOG4107YIM	Involved in the transcription termination process (By similarity)
VS_2410	ENOG4108UTT	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity)
VS_2413	ENOG4105D1W	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity)
VS_2414	ENOG4108Z11	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity)
VS_2415	ENOG4105C2S	Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity)
VS_2416	ENOG4105CGT	Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity)
VS_2417	ENOG4108UVK	Binds to the sigma-S subunit of RNA polymerase, activating expression of sigma-S-regulated genes. Stimulates RNA polymerase holoenzyme formation and may bind to several other sigma factors, such as sigma-70 and sigma-32 (By similarity)
VS_2418	ENOG4108DJV	Fermentation respiration switch protein
VS_2419	ENOG4108DJV	Fermentation respiration switch protein
VS_2420	ENOG4105DYA	Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity)
VS_2421	ENOG4105C7N	Xanthine uracil vitamin C permease
VS_2422	ENOG4105CIN	aminoacyl-histidine dipeptidase
VS_2428	ENOG4107VZP	Hemolysin-type calcium-binding repeat 2 copies family protein
VS_2430	ENOG4105FGV	Chromate
VS_2431	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
VS_2432	ENOG41089I4	Inherit from COG: Glycosyl transferase, family 2
VS_2450	ENOG4108IQE	Amp-dependent synthetase and ligase
VS_2452	ENOG4105ETT	transcriptional Regulator, LysR family
VS_2453	ENOG4105VYA	Uncharacterized conserved protein (DUF2132)
VS_2454	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
VS_2456	ENOG4105DNJ	May play a role in the repair of endogenous alkylation damage (By similarity)
VS_2458	ENOG4105EAC	phosphoserine phosphatase
VS_2460	ENOG4105D3A	purine nucleoside phosphorylase DeoD-type
VS_2461	ENOG4105CZG	Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity)
VS_2462	ENOG4105CMW	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity)
VS_2463	ENOG4105FCI	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity)
VS_2464	ENOG4105D9N	nucleoside
VS_2465	ENOG4105EYA	deoxyribonuclease
VS_2467	ENOG4105C8A	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity)
VS_2468	ENOG4105KEG	ribosomal-protein-alanine acetyltransferase
VS_2470	ENOG4108YYD	acetyltransferase
VS_2471	ENOG4105XPQ	lipid carrier protein
VS_2472	ENOG4105BZU	Histidine kinase
VS_2473	ENOG4105CFP	Peptidase U32
VS_2474	ENOG4106RZ4	Peptidase U32
VS_2475	ENOG4107R73	Mate efflux family protein
VS_2478	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
VS_2479	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
VS_2480	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
VS_2481	ENOG4105KG7	Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity)
VS_2482	ENOG4107QHU	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
VS_2483	ENOG4105CHV	Transcription elongation factor NusA
VS_2484	ENOG4105K7D	Required for maturation of 30S ribosomal subunits (By similarity)
VS_2488	ENOG4107QJF	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity)
VS_2489	ENOG4105EEI	dihydropteroate synthase
VS_2490	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
VS_2491	ENOG4105F7M	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity)
VS_2492	ENOG4105HBR	Rna-binding protein
VS_2493	ENOG4108UKH	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
VS_2494	ENOG4105FCK	Membrane
VS_2495	ENOG4106HRJ	d-alanyl-d-alanine carboxypeptidase
VS_2496	ENOG4105CJW	magnesium transporter
VS_2497	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
VS_2498	ENOG4105DR5	peptidase
VS_2501	ENOG4108YX9	iron--sulfur cluster insertion protein erpA
VS_2502	ENOG4105CDM	Glutamate-1-semialdehyde aminotransferase
VS_2503	ENOG4105IPI	Membrane
VS_2504	ENOG4105D8J	Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity)
VS_2505	ENOG4105BZU	Histidine kinase
VS_2506	ENOG4107QRA	Extracellular solute-binding protein, family 5
VS_2508	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
VS_2509	ENOG4105C3U	ABC transporter
VS_2510	ENOG4108JQ7	(ABC) transporter
VS_2512	ENOG4105RD7	BadF BadG BcrA BcrD
VS_2513	ENOG4105E2D	ec 3.2.1.52
VS_2516	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
VS_2520	ENOG4108YZA	Nitrogen regulatory protein pii
VS_2521	ENOG4105XTV	UPF0231 protein
VS_2522	ENOG4107QIJ	Aconitate hydratase 2
VS_2523	ENOG4105D78	K07001 NTE family protein
VS_2524	ENOG4105BZ4	penicillin-binding protein
VS_2526	ENOG4105CQ7	ATP-dependent helicase
VS_2527	ENOG4105PW4	Sugar fermentation stimulation protein homolog
VS_2528	ENOG4108V7X	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
VS_2529	ENOG4106F3G	Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity)
VS_2530	ENOG4105DJ0	Poly(A) Polymerase
VS_2531	ENOG4105K8U	2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
VS_2532	ENOG4105CCG	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity)
VS_2533	ENOG4108IAA	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity)
VS_2534	ENOG4105E3A	(ABC) transporter
VS_2535	ENOG4105DA5	(ABC) transporter
VS_2536	ENOG4105CHH	sulfate transporter
VS_2537	ENOG41077A9	carbonic anhydrase
VS_2538	ENOG4108UGV	hypoxanthine phosphoribosyltransferase
VS_2539	ENOG410630P	Transcriptional regulator
VS_2540	ENOG4107QN2	dihydrolipoyl dehydrogenase
VS_2541	ENOG4107QSN	dihydrolipoamide acetyltransferase
VS_2542	ENOG4105DAQ	Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity)
VS_2543	ENOG41073TP	transcriptional regulator
VS_2546	ENOG4105D18	nicotinate-nucleotide pyrophosphorylase
VS_2548	ENOG4107QHF	type ii secretion system protein e
VS_2549	ENOG4105D7Q	type ii secretion system
VS_2550	ENOG4105EHH	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity)
VS_2551	ENOG4108ZQD	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity)
VS_2552	ENOG4108ZQD	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity)
VS_2553	ENOG4105DHA	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity (By similarity)
VS_2554	ENOG41067SF	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity)
VS_2555	ENOG4108YY1	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity)
VS_2556	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
VS_2557	ENOG4108ZR6	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity)
VS_2558	ENOG4105K5M	30s ribosomal protein S16
VS_2559	ENOG4105CB9	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
VS_2560	ENOG4106KVJ	cytochrome C assembly protein
VS_2561	ENOG4108JU6	CBS domain protein
VS_2562	ENOG4106762	Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity)
VS_2564	ENOG4105D9M	gamma-glutamylcysteine synthetase
VS_2566	ENOG4105W39	Membrane
VS_2567	ENOG4105DQ4	alcohol dehydrogenase
VS_2568	ENOG4105D9Q	decarboxylase (Beta subunit)
VS_2569	ENOG4107QSA	Oxaloacetate decarboxylase
VS_2581	ENOG4105VM8	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity)
VS_2582	ENOG4105CFH	Aspartokinase
VS_2583	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
VS_2586	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
VS_2588	ENOG4105D7M	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
VS_2590	ENOG4107FKK	extracellular solute-binding protein family 1
VS_2592	ENOG4105EG2	ABC transporter, permease
VS_2596	ENOG4105C68	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)
VS_2597	ENOG4107TH8	cina domain protein
VS_2598	ENOG4105D86	that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity)
VS_2599	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
VS_2601	ENOG4105E26	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity)
VS_2602	ENOG4105CV2	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity)
VS_2603	ENOG4106NZV	Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity)
VS_2604	ENOG4108UH8	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity)
VS_2605	ENOG4105CE5	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity)
VS_2606	ENOG4105XX3	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity)
VS_2607	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
VS_2609	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
VS_2610	ENOG4105DXN	mazG family
VS_2611	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
VS_2612	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
VS_2614	ENOG4105BZU	Histidine kinase
VS_2615	ENOG4105KJV	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity)
VS_2616	ENOG4105CSZ	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity)
VS_2617	ENOG41071DT	Involved in DNA repair and RecF pathway recombination (By similarity)
VS_2618	ENOG4105CWT	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity)
VS_2619	ENOG4108ZBM	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity)
VS_2620	ENOG4105C3F	Signal peptidase i
VS_2621	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
VS_2625	ENOG4105EMN	RNA polymerase sigma factor
VS_2627	ENOG4108IYU	L-aspartate oxidase
VS_2629	ENOG4105Y75	tpr repeat protein
VS_2630	ENOG4106XY2	Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity)
VS_2633	ENOG4105EAK	ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family
VS_2634	ENOG4105D0A	hydroxylase
VS_2636	ENOG4107YUN	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity)
VS_2638	ENOG4105MK2	5-formyltetrahydrofolate cyclo-ligase
VS_2639	ENOG4105E66	phosphoriboisomerase A
VS_2640	ENOG4108JQ1	Dehydrogenase
VS_2642	ENOG4105CXD	Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity)
VS_2643	ENOG4108ZUB	Lysine exporter protein (Lyse ygga)
VS_2644	ENOG4105D64	Mechanosensitive ion channel
VS_2645	ENOG4105D2N	Aldolase
VS_2648	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
VS_2650	ENOG4108JP0	extracellular solute-binding protein family 1
VS_2651	ENOG4105DHQ	Histidine kinase
VS_2652	ENOG4105DPZ	Two component transcriptional regulator (Winged helix family
VS_2654	ENOG4105CV1	Transketolase (EC 2.2.1.1)
VS_2655	ENOG4105CPH	Catalyzes the formation of S-adenosylmethionine from methionine and ATP
VS_2656	ENOG4108IPW	abc transporter atp-binding protein
VS_2658	ENOG4105EHG	Permease protein
VS_2659	ENOG4107RPC	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
VS_2661	ENOG4105EE8	May catalyze the methylation of C-1 in cobalt-precorrin- 5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A (By similarity)
VS_2662	ENOG41081F0	Precorrin-8x methylmutase
VS_2663	ENOG4105CX4	Precorrin-6y C5,15-methyltransferase
VS_2665	ENOG4108P62	biosynthesis protein (CbiG)
VS_2667	ENOG4105E4R	Precorrin-3B C17-methyltransferase
VS_2668	ENOG4105CIA	precorrin-4 C(11)-methyltransferase
VS_2669	ENOG4105DH2	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity)
VS_2670	ENOG4105EFT	decarboxylase
VS_2671	ENOG4105C0Y	Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity)
VS_2673	ENOG4105GPY	SprT protein
VS_2674	ENOG4105RWS	endonuclease I
VS_2677	ENOG4105QF0	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity)
VS_2678	ENOG4105D7Z	glutathione synthase
VS_2679	ENOG4108UJU	UPF0301 protein
VS_2681	ENOG4105CZX	twitching motility protein
VS_2682	ENOG4105CZX	twitching motility protein
VS_2683	ENOG4105DFA	alanine racemase domain protein
VS_2684	ENOG4105II7	pyrroline-5-carboxylate reductase
VS_2685	ENOG4108VIA	integral membrane protein
VS_2686	ENOG4105VZ9	UPF0235 protein
VS_2688	ENOG4108V82	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
VS_2689	ENOG4105CSA	Coproporphyrinogen iii oxidase
VS_2690	ENOG4105CSV	Glutaminase
VS_2691	ENOG4105CZ1	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity)
VS_2692	ENOG4105CEN	a g-specific adenine glycosylase
VS_2693	ENOG4105KMG	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity)
VS_2694	ENOG4106S48	Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division
VS_2723	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
VS_2727	ENOG4108K5H	permease YjgP YjgQ family protein
VS_2728	ENOG4108M8S	permease YjgP YjgQ family protein
VS_2729	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
VS_2730	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
VS_2731	ENOG4105MYG	DNA polymerase iii, chi subunit
VS_2732	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
VS_2735	ENOG4108MJ3	acetyltransferase
VS_2738	ENOG4105CEU	Arginine dihydrolase
VS_2739	ENOG4105DBV	ornithine carbamoyltransferase
VS_2740	ENOG4105CXT	aspartate transcarbamylase
VS_2741	ENOG4108R9M	Involved in allosteric regulation of aspartate carbamoyltransferase (By similarity)
VS_2742	ENOG4105KME	endoribonuclease L-psp
VS_2743	ENOG4107S7E	1-acyl-sn-glycerol-3-phosphate acyltransferase
VS_2744	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
VS_2745	ENOG4105VFK	BolA family
VS_2747	ENOG4105E3I	toluene tolerance
VS_2748	ENOG4107PE3	Mammalian cell entry related domain protein
VS_2749	ENOG4105CY3	ABC transporter, permease
VS_2750	ENOG4105DHJ	ABC, transporter
VS_2752	ENOG4105C2X	Arabinose 5-phosphate isomerase
VS_2753	ENOG4108Z4R	3-deoxy-d-manno-octulosonate 8-phosphate phosphatase
VS_2755	ENOG4105WI0	lipopolysaccharide transport periplasmic protein lptA
VS_2756	ENOG4108IUZ	ABC transporter
VS_2757	ENOG4105DTW	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
VS_2758	ENOG41080QH	sigma 54 modulation protein ribosomal protein S30EA
VS_2759	ENOG4107RM2	PTS IIA-like nitrogen-regulatory protein PtsN
VS_2760	ENOG4105C21	Displays ATPase and GTPase activities (By similarity)
VS_2761	ENOG41080Z8	PHOSPHOCARRIER protein
VS_2762	ENOG4105CJW	magnesium transporter
VS_2763	ENOG4105CMS	peptidase U62, modulator of DNA gyrase
VS_2764	ENOG4105N42	UPF0307 protein
VS_2765	ENOG4107T0D	ABC, transporter
VS_2766	ENOG4106SMU	thiamine transporter membrane protein
VS_2767	ENOG4105DP9	ABC transporter
VS_2769	ENOG4108UMA	3-octaprenyl-4-hydroxybenzoate carboxy-lyase
VS_2770	ENOG4105DFU	Cell wall formation (By similarity)
VS_2771	ENOG4105CZI	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
VS_2773	ENOG41066HZ	AIG2-like family
VS_2774	ENOG4105MA0	exported protein
VS_2775	ENOG4105CFU	surface antigen
VS_2776	ENOG4108HW8	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity)
VS_2779	ENOG4108UUE	Transcriptional regulator
VS_2786	ENOG4108I67	Catalyzes the synthesis of activated sulfate (By similarity)
VS_2788	ENOG4105C3T	may be the GTPase, regulating ATP sulfurylase activity (By similarity)
VS_2789	ENOG4105C11	sulfate adenylyltransferase), subunit 2
VS_2790	ENOG4107RNS	bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic
VS_2799	ENOG4107YB6	acetyltransferase, (GNAT) family
VS_2801	ENOG4108UBT	opacity-associated protein
VS_2803	ENOG4108V1T	peptidylprolyl cis-trans isomerase
VS_2806	ENOG4108ZT0	50S ribosomal protein l17
VS_2807	ENOG4105CTF	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
VS_2808	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
VS_2809	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
VS_2810	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
VS_2811	ENOG4105CGG	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity)
VS_2812	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
VS_2813	ENOG4105VPB	50S ribosomal protein L30
VS_2814	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
VS_2815	ENOG4105K4C	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity)
VS_2816	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
VS_2817	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
VS_2818	ENOG4105VBI	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
VS_2819	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
VS_2821	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
VS_2822	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
VS_2823	ENOG41083MP	50s ribosomal protein l29
VS_2825	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
VS_2826	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
VS_2828	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
VS_2829	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
VS_2830	ENOG41080KG	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
VS_2831	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
VS_2832	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
VS_2833	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
VS_2834	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
VS_2836	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
VS_2839	ENOG4108ZKU	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity)
VS_2840	ENOG4108ZAT	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity)
VS_2841	ENOG4105WWK	YheO domain protein
VS_2842	ENOG4108V1T	peptidylprolyl cis-trans isomerase
VS_2844	ENOG41069P5	Protein slyX homolog
VS_2845	ENOG4105D44	asparaginase
VS_2846	ENOG4108YZY	peptidylprolyl cis-trans isomerase
VS_2850	ENOG4105C5H	ABC transporter
VS_2852	ENOG4105DNZ	Alpha Beta Hydrolase
VS_2853	ENOG4105YP7	UPF0270 protein
VS_2854	ENOG4105CJE	phosphoribulokinase (EC 2.7.1.19)
VS_2855	ENOG4107RYR	Transcriptional regulator, Crp Fnr family
VS_2859	ENOG4105C26	Dehydrogenase
VS_2862	ENOG4105DDQ	anthranilate synthase
VS_2863	ENOG4105BZU	Histidine kinase
VS_2866	ENOG4105C31	Tryptophanyl-tRNA synthetase
VS_2867	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
VS_2868	ENOG4105DJV	ribulose-phosphate 3-epimerase
VS_2869	ENOG4105DFE	Dna adenine methylase
VS_2871	ENOG4105D49	3-dehydroquinate synthase
VS_2872	ENOG4105KHV	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity)
VS_2873	ENOG4105E4G	Type IV pilus
VS_2878	ENOG4108JQC	penicillin-binding protein 1A
VS_2880	ENOG4105EHV	domain protein
VS_2881	ENOG4107QN2	dihydrolipoyl dehydrogenase
VS_2882	ENOG4105M4H	endoribonuclease L-psp
VS_2885	ENOG4105CH7	arginosuccinase
VS_2886	ENOG4105CDH	Citrulline--aspartate ligase
VS_2887	ENOG4105CAS	nag kinase
VS_2888	ENOG4105C0N	N-acetylglutamate semialdehyde dehydrogenase
VS_2889	ENOG4105CWC	Acetylornithine deacetylase
VS_2890	ENOG4105CCA	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity)
VS_2892	ENOG4105SYT	Methylenetetrahydrofolate reductase
VS_2893	ENOG4105CFH	Aspartokinase
VS_2894	ENOG4105C28	cystathionine
VS_2895	ENOG4105GGQ	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis (By similarity)
VS_2896	ENOG4105C6K	Malic enzyme
VS_2897	ENOG4105VFB	Binds the 23S rRNA (By similarity)
VS_2898	ENOG4105C25	Primosomal protein n'
VS_2899	ENOG4105ETE	Transcriptional regulator (LacI family
VS_2901	ENOG4108R5P	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity)
VS_2902	ENOG4105C4N	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity)
VS_2903	ENOG4105EIS	1,4-dihydroxy-2-naphthoate octaprenyltransferase
VS_2904	ENOG4108YYX	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity)
VS_2905	ENOG41065UX	Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA (By similarity)
VS_2906	ENOG4105CBT	Fructose-1,6-bisphosphatase
VS_2909	ENOG4108VTS	Membrane
VS_2913	ENOG4105CTQ	phosphohexokinase
VS_2914	ENOG41076HS	cation diffusion facilitator family transporter
VS_2916	ENOG4105E3W	Two component transcriptional regulator (Winged helix family
VS_2917	ENOG4105E0F	Histidine kinase
VS_2919	ENOG4108UIQ	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity)
VS_2921	ENOG4108IJ0	Aspartate ammonia-lyase
VS_2922	ENOG4105DS2	Anaerobic c4-dicarboxylate transporter
VS_2923	ENOG4105CSX	c4-dicarboxylate anaerobic carrier
VS_2924	ENOG4105CEU	Arginine dihydrolase
VS_2925	ENOG4105C5B	carbamate kinase
VS_2926	ENOG4105DBV	ornithine carbamoyltransferase
VS_2927	ENOG4105CXT	aspartate transcarbamylase
VS_2928	ENOG4108R9M	Involved in allosteric regulation of aspartate carbamoyltransferase (By similarity)
VS_2929	ENOG410682Y	Regulates arginine biosynthesis genes (By similarity)
VS_2930	ENOG4105CSG	Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity)
VS_2932	ENOG4105C3N	Participates in control of cell volume in low-osmolarity conditions (By similarity)
VS_2935	ENOG4107QN1	sodium solute
VS_2937	ENOG4105C9Q	fumarate hydratase class II
VS_2938	ENOG4105BZU	Histidine kinase
VS_2939	ENOG4105D8G	Major Facilitator superfamily
VS_2942	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
VS_2943	ENOG4108Z38	Catalyzes a trans-dehydration via an enolate intermediate (By similarity)
VS_2944	ENOG4105KM4	Acetyl-CoA carboxylase, biotin carboxyl carrier protein
VS_2945	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
VS_2946	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
VS_2947	ENOG4105CEH	Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity)
VS_2948	ENOG4105VY0	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity)
VS_2949	ENOG4105BZU	Histidine kinase
VS_2950	ENOG4105W1Y	Transcriptional regulator
VS_2951	ENOG4105DC1	bifunctional purine biosynthesis protein purh
VS_2952	ENOG4105C12	Phosphoribosylglycinamide synthetase
VS_2956	ENOG4105R2J	Conserved Protein
VS_2958	ENOG4108RG0	uracil-dna glycosylase
VS_2959	ENOG4105CFZ	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity)
VS_2960	ENOG4105E09	nadh pyrophosphatase
VS_2961	ENOG4108ZVW	Anti-RNA polymerase sigma 70 factor
VS_2962	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
VS_2963	ENOG4108IIJ	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
VS_2964	ENOG4105KBC	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
VS_2965	ENOG4108VZM	50s ribosomal protein L10
VS_2967	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
VS_2968	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
VS_2970	ENOG4105E5V	Participates in transcription elongation, termination and antitermination (By similarity)
VS_2971	ENOG4105PM1	preprotein translocase subunit SecE
VS_2972	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
VS_2978	ENOG4105CS9	pantothenic acid kinase
VS_2979	ENOG4105HJX	Biotin- acetyl-CoA-carboxylase ligase
VS_2980	ENOG4105D4A	Cell wall formation (By similarity)
VS_2982	ENOG4105JIM	Phosphatidylserine synthase
VS_2996	ENOG4105F03	Provides the (R)-glutamate required for cell wall biosynthesis (By similarity)
VS_2998	ENOG4105CHI	Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity)
VS_3000	ENOG4107R9T	Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNAs (By similarity)
VS_3003	ENOG4105DX1	Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity)
VS_3004	ENOG4107R73	Mate efflux family protein
VS_3006	ENOG4105DS7	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity)
VS_3007	ENOG41080IJ	Diacylglycerol kinase
VS_3009	ENOG4105E55	glycerol-3-phosphate acyltransferase
VS_3012	ENOG4105C4G	Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity)
VS_3013	ENOG4105VEI	Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity)
VS_3015	ENOG4105X6C	Flagellar basal body-associated protein FliL
VS_3016	ENOG4105EBW	Rhomboid-type serine protease that catalyzes intramembrane proteolysis (By similarity)
VS_3017	ENOG4105M78	Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity)
VS_3018	ENOG4105DEK	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
VS_3019	ENOG4105CRP	Part of the ABC transporter FtsEX involved in
VS_3020	ENOG4105CAK	Cell division ATP-binding protein ftsE
VS_3021	ENOG4105CCP	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
VS_3021	ENOG4105CCP	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
VS_3023	ENOG4106H78	methyltransferase
VS_3025	ENOG41076UM	multiple antibiotic resistance (MarC)-related protein
VS_3033	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
VS_3034	ENOG41082YX	Transcriptional regulator, arsr family
VS_3035	ENOG4105D58	Diguanylate phosphodiesterase
VS_3036	ENOG410829K	Lysine exporter protein (Lyse ygga)
VS_3037	ENOG4108EUD	Lysophospholipase
VS_3038	ENOG4105DQF	Hydrolase
VS_3041	ENOG4106IUH	DTW domain containing protein
VS_3042	ENOG4105BZU	Histidine kinase
VS_3043	ENOG4105BZU	Histidine kinase
VS_3044	ENOG4105DFC	had-superfamily hydrolase, subfamily ia, variant
VS_3045	ENOG4108IYS	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
VS_3047	ENOG4105E4Z	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity)
VS_3048	ENOG4105CU5	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity)
VS_3050	ENOG4105XQ6	frataxin-like protein
VS_3052	ENOG4105D6W	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity)
VS_3053	ENOG41076E6	Uroporphyrinogen-III Synthase
VS_3054	ENOG4105ECF	c-methyltransferase
VS_3055	ENOG410601J	HemY protein
VS_3067	ENOG4107QK7	reductase
VS_3069	ENOG4105D3H	Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity)
VS_3071	ENOG4105C4P	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity)
VS_3072	ENOG4105K63	Thioredoxin
VS_3073	ENOG4105C1J	atp-dependent rna helicase
VS_3074	ENOG4105C9X	ppx gppa phosphatase
VS_3075	ENOG4105EX9	Membrane
VS_3077	ENOG4105C9U	ATP-dependent DNA helicase RecQ
VS_3078	ENOG4105FR1	rard protein
VS_3081	ENOG4105CFB	Gamma-glutamyltranspeptidase (EC 2.3.2.2)
VS_3083	ENOG4108V1J	Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity)
VS_3084	ENOG4105C4R	Atp-dependent dna helicase
VS_3086	ENOG4105E18	UPF0276 protein
VS_3091	ENOG4105G2Y	Transcriptional regulator
VS_3092	ENOG4105DC7	peptidase M24
VS_3092	ENOG4105DC7	peptidase M24
VS_3093	ENOG4105D41	biosynthesis protein thiH
VS_3094	ENOG4105CA8	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity)
VS_3095	ENOG4105WHD	thiamine biosynthesis protein ThiS
VS_3096	ENOG4105D06	uba thif-type nad fad binding protein
VS_3097	ENOG4108UV6	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity)
VS_3098	ENOG4105CBF	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity)
VS_3100	ENOG4105WMR	Protein CrcB homolog
VS_3101	ENOG4105E3B	Multicopper oxidase
VS_3115	ENOG4108Z0R	Transferase
VS_3117	ENOG4105E2X	shikimate dehydrogenase
VS_3118	ENOG4105DBS	Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity)
VS_3119	ENOG4105EK0	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
VS_3120	ENOG4108UM6	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity)
VS_3121	ENOG4105CY8	phosphoribosylaminoimidazole carboxylase atpase subunit
VS_3122	ENOG4108WI1	Dna topoisomerase
VS_3123	ENOG4108RPN	Protein smg homolog
VS_3124	ENOG4105C79	DNA protecting protein DprA
VS_3127	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
VS_3128	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
VS_3129	ENOG4105C1A	potassium transporter peripheral membrane
VS_3131	ENOG4105D37	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity)
VS_3133	ENOG4108UT2	hemolysin iii
VS_3134	ENOG4108N23	SpoOM-related protein
VS_3136	ENOG4105PC1	Conserved Protein
VS_3139	ENOG4105E27	serine threonine protein kinase
VS_3140	ENOG4108Z33	Thiol disulfide Interchange Protein
VS_3142	ENOG4105C0P	Mg chelatase subunit ChlI
VS_3144	ENOG4105P3Y	Acetolactate synthase 2 regulatory subunit
VS_3145	ENOG4105CM2	brancheD-chain amino acid aminotransferase
VS_3146	ENOG4105C01	Dihydroxy-acid dehydratase
VS_3147	ENOG4105C7B	Threonine dehydratase
VS_3148	ENOG4105F52	Transcriptional regulator
VS_3149	ENOG4105CZQ	inner membrane transport protein YdhC
VS_3150	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
VS_3151	ENOG4105KNM	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
VS_3152	ENOG4105C4J	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
VS_3153	ENOG4105J80	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity)
VS_3154	ENOG4105CDG	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity)
VS_3155	ENOG4107S15	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
VS_3157	ENOG4105KY6	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
VS_3158	ENOG4105EE4	it plays a direct role in the translocation of protons across the membrane (By similarity)
VS_3159	ENOG410684E	atp synthase
VS_3160	ENOG4105FA0	parb-like partition protein
VS_3161	ENOG4107QJE	Chromosome Partitioning Protein
VS_3162	ENOG4105D28	Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity)
VS_3163	ENOG4107RE5	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity)
VS_II0002	ENOG4106RMF	ParB family
VS_II0003	ENOG4105E0I	Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity)
VS_II0008	ENOG4107QZV	Type I secretion membrane fusion protein
VS_II0009	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
VS_II0010	ENOG4105CQZ	Histidine kinase
VS_II0011	ENOG4108S7T	Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity)
VS_II0012	ENOG4108ZXC	Two component transcriptional regulator, luxr family
VS_II0014	ENOG4105E6M	Sulphatase-modifying factor protein
VS_II0019	ENOG4105C26	Dehydrogenase
VS_II0021	ENOG4105CK7	Sodium proline symporter
VS_II0024	ENOG4105EW9	transcriptional regulator AsnC family
VS_II0025	ENOG4108UH6	UPF0754 membrane protein
VS_II0026	ENOG4105BZ1	(ABC) transporter
VS_II0031	ENOG4105DIJ	Phosphoethanolamine transferase
VS_II0038	ENOG4108IA2	Sodium pantothenate symporter
VS_II0039	ENOG4107SS6	2-dehydro-3-deoxygluconokinase
VS_II0040	ENOG4108UHU	Aldolase
VS_II0041	ENOG4105E2D	ec 3.2.1.52
VS_II0043	ENOG4105JJR	Histidine kinase
VS_II0044	ENOG4107EXC	regulatoR
VS_II0045	ENOG4105BZU	Histidine kinase
VS_II0048	ENOG4107RCH	Diaminopropionate ammonia-lyase
VS_II0051	ENOG4105CH2	amidohydrolase
VS_II0052	ENOG4108KJ1	Trap dicarboxylate transporter, dctp subunit
VS_II0054	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
VS_II0056	ENOG4108MHR	Repressor involved in choline regulation of the bet genes (By similarity)
VS_II0057	ENOG4105C26	Dehydrogenase
VS_II0058	ENOG4105CZ6	Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity)
VS_II0061	ENOG4108IJ7	Glycine betaine
VS_II0062	ENOG41067TZ	transcriptional regulator, MarR family
VS_II0066	ENOG4108Z24	l-2,4-diaminobutyric acid acetyltransferase
VS_II0067	ENOG4108JPW	Aminotransferase
VS_II0068	ENOG4108Z6K	Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant (By similarity)
VS_II0069	ENOG4105CZK	Aspartate kinase
VS_II0072	ENOG4108UW5	maltose o-acetyltransferase
VS_II0073	ENOG4105EKD	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity)
VS_II0074	ENOG4105G2Y	Transcriptional regulator
VS_II0079	ENOG4105C3R	Methionine synthase
VS_II0092	ENOG4105EUZ	Beta-lactamase domain protein
VS_II0095	ENOG4105KHA	Glyoxalase Bleomycin resistance protein (Dioxygenase
VS_II0097	ENOG4105CS2	ec 3.2.1.21
VS_II0098	ENOG4105DDV	Transcriptional regulator (LacI family
VS_II0099	ENOG4108UW5	maltose o-acetyltransferase
VS_II0100	ENOG4105F27	Major Facilitator
VS_II0101	ENOG4105HEI	LysR family (Transcriptional regulator
VS_II0105	ENOG4105NAE	bifunctional deaminase-reductase domain protein
VS_II0107	ENOG4107RZC	phospholipase d
VS_II0113	ENOG4105C6V	Glycerol-3-phosphate dehydrogenase
VS_II0114	ENOG4105E98	transcriptional regulator DeoR family
VS_II0115	ENOG4108JQ0	Key enzyme in the regulation of glycerol uptake and metabolism (By similarity)
VS_II0116	ENOG4105D8C	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity)
VS_II0118	ENOG4105F04	LysR family Transcriptional regulator
VS_II0119	ENOG4105D6J	arsenicaL-resistance protein
VS_II0121	ENOG4105DQF	Hydrolase
VS_II0123	ENOG4105T0Z	Conserved Protein
VS_II0124	ENOG4105HEI	LysR family (Transcriptional regulator
VS_II0130	ENOG4107VXZ	Hydrolase
VS_II0131	ENOG4105DJV	ribulose-phosphate 3-epimerase
VS_II0136	ENOG41064BZ	L-xylulose 5-phosphate 3-epimerase
VS_II0137	ENOG4105J4Q	Transcriptional regulator
VS_II0139	ENOG4105CMG	Carbohydrate kinase
VS_II0141	ENOG4108K4B	hydrolase
VS_II0143	ENOG4105DR6	Trap dicarboxylate transporter, dctp subunit
VS_II0144	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
VS_II0145	ENOG4105XDZ	Tripartite ATP-independent periplasmic transporter
VS_II0147	ENOG4105BZW	Glycerate kinase
VS_II0148	ENOG4105CH6	catalase
VS_II0149	ENOG4108NRW	Phospholipase, patatin family
VS_II0150	ENOG4105C5I	Dehydrogenase
VS_II0152	ENOG4105DP0	ferredoxin-NADP reductase
VS_II0153	ENOG4106HNH	Acyl-transferase
VS_II0158	ENOG4108KDD	Involved in the transport of maltose and maltodextrins (By similarity)
VS_II0162	ENOG4107FKK	extracellular solute-binding protein family 1
VS_II0163	ENOG4105CG3	alpha amylase, catalytic region
VS_II0171	ENOG4105EW9	transcriptional regulator AsnC family
VS_II0172	ENOG4105JQN	Transcriptional regulator
VS_II0177	ENOG4105E06	May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity)
VS_II0183	ENOG41061ZR	Transcriptional regulator
VS_II0184	ENOG4107QQN	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity)
VS_II0185	ENOG4107RTM	4-alpha-glucanotransferase (EC 2.4.1.25)
VS_II0186	ENOG4105C9C	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity)
VS_II0188	ENOG4108JJB	ABC transporter
VS_II0189	ENOG4108V7D	UPF0397 protein
VS_II0190	ENOG4105EFX	secretion protein, HlyD family
VS_II0191	ENOG4105KK7	inner membrane protein YiaW
VS_II0193	ENOG4106TD9	Diguanylate cyclase
VS_II0197	ENOG4105D3A	purine nucleoside phosphorylase DeoD-type
VS_II0198	ENOG4107N1Q	ErfK YbiS YcfS YnhG family protein
VS_II0200	ENOG4105C1J	atp-dependent rna helicase
VS_II0201	ENOG4105KUU	lipolytic protein G-D-S-L family
VS_II0202	ENOG4107IFA	Lipase (EC 3.1.1.3)
VS_II0204	ENOG4105C8Q	Methyl-accepting chemotaxis
VS_II0205	ENOG4107S17	Phosphate-binding protein
VS_II0206	ENOG4105C8U	phosphate abc transporter
VS_II0207	ENOG4105E2Z	phosphate ABC transporter (Permease
VS_II0208	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
VS_II0211	ENOG4107QVM	von Willebrand factor, type A
VS_II0212	ENOG4107QVM	von Willebrand factor, type A
VS_II0215	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
VS_II0216	ENOG41069D7	Methyl-accepting chemotaxis
VS_II0219	ENOG4108IJ9	(ABC) transporter
VS_II0220	ENOG4107FKK	extracellular solute-binding protein family 1
VS_II0221	ENOG4105D56	permease protein
VS_II0222	ENOG4105EG2	ABC transporter, permease
VS_II0231	ENOG4105D64	Mechanosensitive ion channel
VS_II0232	ENOG4105DUM	transcriptional regulator, lysR family
VS_II0236	ENOG4105CJW	magnesium transporter
VS_II0239	ENOG4105EWV	Sodium calcium exchanger membrane region
VS_II0240	ENOG4107RAB	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
VS_II0241	ENOG4107QN8	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
VS_II0243	ENOG4108K8S	endonuclease I
VS_II0247	ENOG4105C19	ABC transporter
VS_II0248	ENOG4108HW3	(ABC) transporter
VS_II0249	ENOG4105BZU	Histidine kinase
VS_II0252	ENOG4107G43	radical SAM domain protein
VS_II0260	ENOG4105BZU	Histidine kinase
VS_II0264	ENOG4107RET	Isocitrate lyase
VS_II0267	ENOG4105C26	Dehydrogenase
VS_II0269	ENOG4105C94	Transporter
VS_II0271	ENOG4105BZU	Histidine kinase
VS_II0272	ENOG4105EKE	dihydroorotase
VS_II0274	ENOG4105QVC	MOSC domain-containing protein
VS_II0275	ENOG4107RA1	nh(3)-dependent nad( ) synthetase
VS_II0284	ENOG4108IPX	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity)
VS_II0285	ENOG4105EHG	Permease protein
VS_II0287	ENOG4106GFD	transport protein
VS_II0288	ENOG41090AP	transport protein
VS_II0289	ENOG4105WQ5	TonB family
VS_II0290	ENOG4105D4P	Coproporphyrinogen iii oxidase
VS_II0291	ENOG41090JE	Utilization Protein
VS_II0292	ENOG4105PYN	Pyridoxamine 5-phosphate oxidase-related
VS_II0293	ENOG4107R88	Chemotaxis protein (CheV)
VS_II0294	ENOG4105KQ5	peptidylprolyl cis-trans isomerase
VS_II0296	ENOG4105C8Q	Methyl-accepting chemotaxis
VS_II0297	ENOG4105DWD	nucleoside recognition domain protein
VS_II0302	ENOG4105DR5	peptidase
VS_II0304	ENOG4105F04	LysR family Transcriptional regulator
VS_II0305	ENOG4105E5M	Multidrug resistance protein D
VS_II0308	ENOG4105VW4	glutaredoxin 3
VS_II0309	ENOG4108SXK	Transporter Drug Metabolite Exporter family
VS_II0312	ENOG4106ETB	IIa component
VS_II0313	ENOG4105CZC	PTS system ascorbate-specific transporter subunit IIC
VS_II0316	ENOG4105D9N	nucleoside
VS_II0320	ENOG4105BZU	Histidine kinase
VS_II0321	ENOG4105C1J	atp-dependent rna helicase
VS_II0325	ENOG4106TD9	Diguanylate cyclase
VS_II0326	ENOG4105VEQ	Cold shock protein
VS_II0327	ENOG4105DZC	cytosine deaminase
VS_II0328	ENOG4105DQW	permease for cytosine purines, uracil, thiamine, allantoin
VS_II0329	ENOG4105DQW	permease for cytosine purines, uracil, thiamine, allantoin
VS_II0338	ENOG4105DVH	amino acid
VS_II0339	ENOG4105EW9	transcriptional regulator AsnC family
VS_II0340	ENOG4105CXD	Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity)
VS_II0344	ENOG4105EJ7	Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity)
VS_II0345	ENOG4105CJJ	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity)
VS_II0348	ENOG4105BZU	Histidine kinase
VS_II0351	ENOG41090HJ	UPF0265 protein
VS_II0353	ENOG4108YXG	UPF0502 protein
VS_II0354	ENOG41082IR	Excinuclease ABC C subunit domain protein
VS_II0355	ENOG4108QGH	periplasmic
VS_II0356	ENOG4105BZU	Histidine kinase
VS_II0360	ENOG4105R8A	Heat shock protein
VS_II0362	ENOG4105FBJ	fumarylacetoacetate (faa) hydrolase
VS_II0364	ENOG4107QSU	Phosphoglucomutase phosphomannomutase alpha beta alpha domain
VS_II0371	ENOG4107TQK	Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity)
VS_II0373	ENOG4105F1R	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity)
VS_II0376	ENOG4105VRT	cytoplasmic protein
VS_II0381	ENOG4105W2W	Cytotoxic translational repressor of toxin-antitoxin stability system
VS_II0382	ENOG4105W08	virulence gene repressor rsal
VS_II0387	ENOG4105E99	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity)
VS_II0388	ENOG4107QKV	phosphomannomutase
VS_II0389	ENOG4105CJT	Mannose-1-phosphate guanylyltransferase
VS_II0390	ENOG4105D64	Mechanosensitive ion channel
VS_II0391	ENOG4107ZYR	domain protein
VS_II0393	ENOG4105E0X	reductase
VS_II0394	ENOG4108UKZ	OsmC family
VS_II0395	ENOG4108ZG0	Ompa motb domain protein
VS_II0396	ENOG4108KAZ	Involved in phosphonate degradation (By similarity)
VS_II0397	ENOG4108JPW	Aminotransferase
VS_II0398	ENOG4107STF	Involved in phosphonate degradation (By similarity)
VS_II0400	ENOG4105CJP	fad dependent oxidoreductase
VS_II0402	ENOG4107RCV	ABC transporter, permease
VS_II0405	ENOG4105CH5	extracellular solute-binding protein, family 7
VS_II0407	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
VS_II0408	ENOG4108Z67	carbohydrate kinase, thermoresistant glucokinase family
VS_II0409	ENOG4105C7Q	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity)
VS_II0411	ENOG4105DIQ	Transcriptional regulator
VS_II0413	ENOG4105DUX	Transporter
VS_II0414	ENOG4105EJQ	L-serine dehydratase
VS_II0417	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
VS_II0421	ENOG4105BZ1	(ABC) transporter
VS_II0422	ENOG4105BZ1	(ABC) transporter
VS_II0424	ENOG4105DR5	peptidase
VS_II0428	ENOG4105DHT	Metal Dependent Phosphohydrolase
VS_II0433	ENOG4108YZK	glyoxalase bleomycin resistance protein dioxygenase
VS_II0434	ENOG4105EXG	Transcriptional regulator
VS_II0435	ENOG4105E5W	Transporter
VS_II0436	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
VS_II0437	ENOG4105CPQ	Dehydrogenase
VS_II0440	ENOG4105CKD	glutathione-regulated potassium-efflux system protein
VS_II0441	ENOG4108K2R	Glutathione-regulated potassium-efflux system ancillary protein
VS_II0445	ENOG4105C0A	alcohol dehydrogenase
VS_II0447	ENOG4105PAD	Hydrolase
VS_II0452	ENOG4105EGI	Transcriptional regulator
VS_II0453	ENOG4107RFD	Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity)
VS_II0454	ENOG4105G0K	glycine radical enzyme YjjI family
VS_II0455	ENOG41076CZ	activating enzyme
VS_II0460	ENOG4105EM2	membrane
VS_II0461	ENOG41088T4	Helicase IV
VS_II0463	ENOG4105CV1	Transketolase (EC 2.2.1.1)
VS_II0464	ENOG4105CW3	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity)
VS_II0483	ENOG4105KHC	sulfurtransferase
VS_II0489	ENOG4105D06	uba thif-type nad fad binding protein
VS_II0490	ENOG4105CVM	Molybdenum cofactor synthesis domain protein
VS_II0492	ENOG4105DZW	Dipeptidase
VS_II0494	ENOG4108VWS	Yaeq family
VS_II0495	ENOG4105VEQ	Cold shock protein
VS_II0498	ENOG4105E0A	ABC, transporter
VS_II0500	ENOG4105HFT	AraC family transcriptional regulator
VS_II0501	ENOG4105E0K	tonB-dependent siderophore receptor
VS_II0503	ENOG4105S6R	Iron-hydroxamate transporter permease subunit
VS_II0504	ENOG4108D7R	p-hydroxycinnamoyl CoA hydratase lyase
VS_II0507	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
VS_II0510	ENOG4105BZ1	(ABC) transporter
VS_II0511	ENOG4107QZV	Type I secretion membrane fusion protein
VS_II0515	ENOG4105EP1	Efflux transporter rnd family, mfp subunit
VS_II0516	ENOG4108IJF	Heavy metal efflux pump, CzcA
VS_II0524	ENOG4108Z8G	Alkylphosphonate utilization operon protein PhnA
VS_II0531	ENOG4105DRP	amino acid AbC transporter
VS_II0532	ENOG4105EAB	amino acid AbC transporter
VS_II0533	ENOG4105EAD	ABC transporter
VS_II0534	ENOG4105CDA	abc transporter atp-binding protein
VS_II0535	ENOG4108I6A	alcohol dehydrogenase
VS_II0536	ENOG4105CF7	AraC family transcriptional regulator
VS_II0537	ENOG4105KME	endoribonuclease L-psp
VS_II0542	ENOG4105D9U	N-acetyltransferase
VS_II0543	ENOG4108KBJ	Inner membrane protein YkgB
VS_II0544	ENOG4107YYT	May reduce aminoacrylate peracid to aminoacrylate. Required to remove a toxic intermediate produce by the pyrimidine nitrogen degradation (By similarity)
VS_II0547	ENOG4105BZU	Histidine kinase
VS_II0550	ENOG4105DZ1	carboxypeptidase
VS_II0552	ENOG4105CC0	LysR family Transcriptional regulator
VS_II0554	ENOG4105D3G	Pseudouridine synthase
VS_II0556	ENOG4105CJH	Alcohol dehydrogenase zinc-binding domain protein
VS_II0557	ENOG4108WUH	Transcriptional regulator, TetR family
VS_II0558	ENOG4108V1T	peptidylprolyl cis-trans isomerase
VS_II0563	ENOG4108JUA	Transcriptional regulator
VS_II0564	ENOG4105CJJ	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity)
VS_II0566	ENOG4105CMQ	Chloride channel
VS_II0567	ENOG4105CKI	cobalamin synthesis protein
VS_II0568	ENOG4105C1J	atp-dependent rna helicase
VS_II0569	ENOG410829K	Lysine exporter protein (Lyse ygga)
VS_II0580	ENOG4105EW9	transcriptional regulator AsnC family
VS_II0585	ENOG4105CHU	acetyl-coa acetyltransferase
VS_II0587	ENOG4105D1N	poly(r)-hydroxyalkanoic acid synthase, class
VS_II0589	ENOG4105US7	Histidine kinase
VS_II0590	ENOG4105ETX	regulatoR
VS_II0591	ENOG4105BZS	acriflavin resistance protein
VS_II0594	ENOG4105CPI	Metal Dependent Phosphohydrolase
VS_II0598	ENOG4107QIW	Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity)
VS_II0601	ENOG4105BZU	Histidine kinase
VS_II0602	ENOG4105WH1	Two component transcriptional regulator luxr family
VS_II0603	ENOG4105CEE	C4-dicarboxylate transporter
VS_II0604	ENOG4105FDP	GntR family transcriptional regulator
VS_II0605	ENOG4105DM4	PTS System
VS_II0606	ENOG4105C8I	hydrolase, family 38
VS_II0607	ENOG4105BZW	Glycerate kinase
VS_II0608	ENOG4105EIP	mannose-6-phosphate isomerase
VS_II0612	ENOG4105C9W	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity)
VS_II0617	ENOG4105C26	Dehydrogenase
VS_II0620	ENOG4105E7U	AraC family transcriptional regulator
VS_II0625	ENOG4108V1J	Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity)
VS_II0626	ENOG4108V1J	Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity)
VS_II0629	ENOG4105KNR	Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity)
VS_II0631	ENOG41086KC	Transcriptional regulator
VS_II0638	ENOG4105C5W	Aldolase
VS_II0639	ENOG4108YZ4	nudix hydrolase
VS_II0640	ENOG4107R4Q	Functions as an ATPase. May play a role in metal insertion (metal-chelatase) or as a chaperone (By similarity)
VS_II0641	ENOG4105EV2	VWA domain protein interacting with AAA ATPase
VS_II0656	ENOG4105CA0	peroxidase
VS_II0657	ENOG4105CA0	peroxidase
VS_II0666	ENOG4105EQR	Transposase IS116 IS110 IS902
VS_II0668	ENOG4107QZF	nitrite reductase NADPH large subunit
VS_II0669	ENOG4105WZK	nitrite reductase NADPH small subunit
VS_II0670	ENOG4105TMB	Formate nitrite transporter
VS_II0671	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
VS_II0674	ENOG4105E3W	Two component transcriptional regulator (Winged helix family
VS_II0675	ENOG4105E0F	Histidine kinase
VS_II0676	ENOG4105CK2	sodium dicarboxylate symporter
VS_II0677	ENOG4105E0K	tonB-dependent siderophore receptor
VS_II0681	ENOG4109015	Biopolymer transport protein exbD tolR
VS_II0690	ENOG4105DSE	periplasmic solute binding protein
VS_II0691	ENOG4105DIK	(ABC) transporter
VS_II0692	ENOG4105CC5	ABC transporter
VS_II0696	ENOG4105VXR	cytoplasmic protein
VS_II0697	ENOG4107QI1	Mate efflux family protein
VS_II0704	ENOG4105K63	Thioredoxin
VS_II0705	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
VS_II0711	ENOG4105CJD	(Anaerobic) ribonucleoside-triphosphate reductase
VS_II0712	ENOG4108RDD	Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity)
VS_II0714	ENOG4105ECQ	AraC Family Transcriptional Regulator
VS_II0715	ENOG4105CGF	Aromatic amino acid aminotransferase
VS_II0716	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
VS_II0718	ENOG4105C5H	ABC transporter
VS_II0719	ENOG4105C8Q	Methyl-accepting chemotaxis
VS_II0722	ENOG4105CAA	catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity)
VS_II0723	ENOG4108S6J	ABC transporter, periplasmic molybdate-binding protein
VS_II0724	ENOG4105E0C	molybdate abc transporter
VS_II0725	ENOG4105CGB	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity)
VS_II0729	ENOG4105BZU	Histidine kinase
VS_II0732	ENOG4108IIE	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity)
VS_II0733	ENOG4105C15	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity)
VS_II0741	ENOG4105BZU	Histidine kinase
VS_II0743	ENOG4108ZJT	translation initiation factor, Sui1
VS_II0746	ENOG4105CPF	Cell wall formation (By similarity)
VS_II0747	ENOG4105EGB	membrane protein DamX
VS_II0748	ENOG4105CD5	CoA-binding domain protein
VS_II0749	ENOG4105CWB	LysR family transcriptional Regulator
VS_II0752	ENOG4105CMR	udp-glucose 4-epimerase
VS_II0753	ENOG4105E7W	lamb ycsf family protein
VS_II0754	ENOG4105P4J	Allophanate hydrolase, subunit 1
VS_II0755	ENOG4107R7A	Allophanate hydrolase subunit 2
VS_II0757	ENOG4105CV6	ABC transporter, permease
VS_II0758	ENOG4108I0Y	(ABC) transporter
VS_II0760	ENOG4105RKW	reductase (By
VS_II0763	ENOG4105CJN	penicillin-binding protein
VS_II0764	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
VS_II0768	ENOG4105KNR	Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity)
VS_II0770	ENOG4105KA0	thioesterase Superfamily protein
VS_II0771	ENOG4105D0M	Protease HtpX homolog
VS_II0773	ENOG4105CKF	membrane protein involved in aromatic hydrocarbon degradation
VS_II0774	ENOG4108M0H	Extracellular lipase
VS_II0776	ENOG4105C1J	atp-dependent rna helicase
VS_II0779	ENOG4105DU1	integral membrane protein, terc
VS_II0782	ENOG4105CGH	5'-nucleotidase
VS_II0783	ENOG4105CGH	5'-nucleotidase
VS_II0784	ENOG4105CPB	ATP-dependent endonuclease of the OLD family
VS_II0785	ENOG4108UQ5	membrane protein YcdZ
VS_II0786	ENOG4105DUM	transcriptional regulator, lysR family
VS_II0787	ENOG4105TMB	Formate nitrite transporter
VS_II0788	ENOG4108YYC	ycei family
VS_II0789	ENOG4105DS1	cytochrome b561
VS_II0790	ENOG4105DS1	cytochrome b561
VS_II0794	ENOG4105BZU	Histidine kinase
VS_II0799	ENOG4105C1J	atp-dependent rna helicase
VS_II0800	ENOG4108ZYK	Acyl carrier protein phosphodiesterase
VS_II0802	ENOG4105E0U	tyrosine-specific transport protein
VS_II0804	ENOG4107YBY	Hydrolase
VS_II0805	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
VS_II0808	ENOG4107RE1	Inosine-guanosine kinase
VS_II0809	ENOG4105CKU	formyltetrahydrofolate synthetase
VS_II0810	ENOG4105BZU	Histidine kinase
VS_II0811	ENOG4107VXZ	Hydrolase
VS_II0812	ENOG4108YZN	class I peptide chain release factor
VS_II0818	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
VS_II0819	ENOG4105KE9	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity)
VS_II0820	ENOG4105CBI	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
VS_II0823	ENOG4105DQ6	Transposase
VS_II0833	ENOG4107QI1	Mate efflux family protein
VS_II0834	ENOG4108NIW	Leucine export protein LeuE
VS_II0838	ENOG4109025	Glyoxalase Bleomycin resistance protein (Dioxygenase
VS_II0841	ENOG4105BZC	d-serine deaminase
VS_II0843	ENOG4108V1U	phospholipid-binding protein
VS_II0844	ENOG4105BZU	Histidine kinase
VS_II0853	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
VS_II0859	ENOG4108MGY	Histidine kinase
VS_II0860	ENOG4105DFG	type I secretion outer membrane protein
VS_II0861	ENOG4105BZ1	(ABC) transporter
VS_II0864	ENOG4105BZU	Histidine kinase
VS_II0868	ENOG4105C4X	radical SAM domain protein
VS_II0871	ENOG41064T2	transcriptional regulator, lysR family
VS_II0877	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
VS_II0879	ENOG4105ENH	Sulfatase
VS_II0880	ENOG4105ENH	Sulfatase
VS_II0882	ENOG4108RTV	Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity)
VS_II0887	ENOG4107TIF	Phenazine biosynthesis protein, PhzF family
VS_II0890	ENOG4105BZU	Histidine kinase
VS_II0894	ENOG4105EUH	cytochrome C oxidase, cbb3-type, subunit i
VS_II0904	ENOG4105C26	Dehydrogenase
VS_II0906	ENOG4105CXD	Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity)
VS_II0908	ENOG4105EE4	it plays a direct role in the translocation of protons across the membrane (By similarity)
VS_II0909	ENOG4105KY6	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
VS_II0910	ENOG4107Z0K	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity)
VS_II0911	ENOG4107S15	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
VS_II0912	ENOG4105CDG	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity)
VS_II0913	ENOG4105J80	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity)
VS_II0914	ENOG4105C4J	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
VS_II0915	ENOG4105KNM	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
VS_II0919	ENOG4105C1P	efflux transporter, rnd family, mfp subunit
VS_II0920	ENOG4105DFG	type I secretion outer membrane protein
VS_II0928	ENOG4105CI2	imidazolone-5-propionate hydrolase
VS_II0932	ENOG4108JQ5	ABC transporter
VS_II0933	ENOG4108IYQ	Binding-protein-dependent transport systems inner membrane component
VS_II0934	ENOG4108I5X	binding-protein-dependent transport systems inner membrane Component
VS_II0935	ENOG4105E43	Extracellular solute-binding protein, family 5
VS_II0940	ENOG4105MRB	Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity)
VS_II0941	ENOG4105C2J	ABC transporter
VS_II0942	ENOG4105CNN	ABC, transporter
VS_II0943	ENOG4105E9V	Periplasmic binding protein LacI transcriptional regulator
VS_II0944	ENOG4108RVA	ribokinase
VS_II0945	ENOG4105ETE	Transcriptional regulator (LacI family
VS_II0947	ENOG4105BZU	Histidine kinase
VS_II0948	ENOG4105EPW	hflc protein
VS_II0992	ENOG4105EW9	transcriptional regulator AsnC family
VS_II0999	ENOG4105D9P	serine threonine protein kinase
VS_II1004	ENOG4105CS6	Rhs element vgr protein
VS_II1005	ENOG4108WC9	type VI secretion system effector, hcp1 family
VS_II1006	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
VS_II1007	ENOG4108JUA	Transcriptional regulator
VS_II1010	ENOG4107QKZ	Ompa motb domain protein
VS_II1024	ENOG4105DR5	peptidase
VS_II1027	ENOG4107QZF	nitrite reductase NADPH large subunit
VS_II1029	ENOG4107R3J	Transporter
VS_II1030	ENOG4105D9P	serine threonine protein kinase
VS_II1031	ENOG4107B7Y	DNA-binding transcriptional regulator FruR
VS_II1032	ENOG4105DTZ	bifunctional PTS system fructose-specific transporter subunit IIA HPr protein
VS_II1033	ENOG4105DE4	1-phosphofructokinase
VS_II1034	ENOG4105DM4	PTS System
VS_II1037	ENOG4105BZS	acriflavin resistance protein
VS_II1042	ENOG4105ETX	regulatoR
VS_II1046	ENOG4105CYM	Glutathione S-transferase
VS_II1048	ENOG4105N1F	Hnh endonuclease
VS_II1051	ENOG4105F2V	VRR-NUC domain-containing protein
VS_II1053	ENOG4105BZU	Histidine kinase
VS_II1054	ENOG4108SV3	Tmao reductase system periplasmic protein tort
VS_II1055	ENOG4108Z5K	methylglyoxal synthase
VS_II1056	ENOG4107RHT	methyl-accepting chemotaxis sensory transducer with Pas Pac sensor
VS_II1062	ENOG4107G87	m6 family metalloprotease domain protein
VS_II1063	ENOG4105DXI	Major Facilitator superfamily
VS_II1064	ENOG4108WAV	Transcriptional regulator
VS_II1065	ENOG4105BZU	Histidine kinase
VS_II1066	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
VS_II1067	ENOG4108IPW	abc transporter atp-binding protein
VS_II1068	ENOG4105CM4	permease protein
VS_II1070	ENOG4105DHS	permease protein
VS_II1074	ENOG4105IPI	Membrane
VS_II1076	ENOG4105Y49	secretion protein, HlyD family
VS_II1081	ENOG4105GZI	Transcriptional regulator
VS_II1083	ENOG4108UV6	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity)
VS_II1084	ENOG4105C8Q	Methyl-accepting chemotaxis
VS_II1085	ENOG4105C4U	4-methyl-5-beta-hydroxyethylthiazole kinase
VS_II1086	ENOG4105ETU	transcriptional activator (TenA
VS_II1087	ENOG4107Z6I	Thiamine biosynthesis protein
VS_II1088	ENOG4105Y36	Binding-protein-dependent transport systems, inner membrane component
VS_II1089	ENOG4108YI8	ABC transporter
VS_II1092	ENOG4108RNG	Permease of the drug metabolite transporter
VS_II1097	ENOG4105CYM	Glutathione S-transferase
VS_II1100	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
VS_II1102	ENOG4106050	phage regulatory protein, rha family
VS_II1110	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
VS_II1112	ENOG4108ZXC	Two component transcriptional regulator, luxr family
VS_II1114	ENOG4107QI1	Mate efflux family protein
VS_II1115	ENOG4105ETT	transcriptional Regulator, LysR family
VS_II1116	ENOG4108I0N	Transporter, RarD family, DMT superfamily protein
VS_II1120	ENOG4105CIS	alcohol dehydrogenase
VS_II1123	ENOG4105E0A	ABC, transporter
VS_II1124	ENOG4108U1V	ABC transporter, permease
VS_II1125	ENOG4105DQ5	transport system permease protein
VS_II1126	ENOG4108HUF	Transporter
VS_II1127	ENOG4105GAV	receptor
VS_II1128	ENOG4105E0K	tonB-dependent siderophore receptor
VS_II1130	ENOG4105DUU	IucA IucC family protein
VS_II1132	ENOG4105DBM	Siderophore biosynthesis protein
VS_II1133	ENOG4105CU5	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity)
VS_II1135	ENOG4105C6H	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity)
VS_II1137	ENOG4105C1J	atp-dependent rna helicase
VS_II1138	ENOG4108IEC	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction (By similarity)
VS_II1141	ENOG4107S17	Phosphate-binding protein
VS_II1145	ENOG4107YWA	deoxycytidylate deaminase
VS_II1148	ENOG4105D42	Cleaves the N-terminal amino acid of tripeptides (By similarity)
VS_II1151	ENOG4105CPC	Aldo Keto reductase
VS_II1153	ENOG4108Z4U	Ferredoxin
VS_II1154	ENOG4105DZ0	fad dependent oxidoreductase
VS_II1157	ENOG4105E7Q	Cob(II)yrinic acid a,c-diamide reductase
VS_II1158	ENOG4105C1J	atp-dependent rna helicase
VS_II1160	ENOG4105DE5	Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity)
VS_II1163	ENOG4105C1J	atp-dependent rna helicase
VS_II1164	ENOG4107RGM	aldo keto reductase
VS_II1175	ENOG4105CSG	Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity)
VS_II1177	ENOG4105N6Y	Thioredoxin
VS_II1179	ENOG4105DHT	Metal Dependent Phosphohydrolase
VS_II1181	ENOG4105E0F	Histidine kinase
VS_II1182	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
VS_II1184	ENOG4105BZU	Histidine kinase
VS_II1186	ENOG4105BZU	Histidine kinase
VS_II1187	ENOG4105C6F	GntR Family Transcriptional Regulator
VS_II1188	ENOG4105CZV	ABC transporter
VS_II1194	ENOG4105D1W	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity)
VS_II1196	ENOG4105D3G	Pseudouridine synthase
VS_II1199	ENOG4105C2C	drug resistance transporter, Bcr CflA
VS_II1205	ENOG4105KNR	Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity)
VS_II1207	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
VS_II1208	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
VS_II1214	ENOG4105EX2	Binding-protein-dependent transport systems, inner membrane component
VS_II1215	ENOG4108IJ9	(ABC) transporter
VS_II1216	ENOG4107VXM	glycerophosphoryl diester phosphodiesterase
VS_II1221	ENOG4105EE0	oxidoreductase
VS_II1223	ENOG4105E9S	glutaredoxin 2
VS_II1224	ENOG4105CF9	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity)
VS_II1226	ENOG4105C3S	Mate efflux family protein
VS_II1227	ENOG4105WWK	YheO domain protein
VS_II1228	ENOG4105KME	endoribonuclease L-psp
VS_II1229	ENOG4107R6U	sodium dicarboxylate symporter
VS_II1230	ENOG4107QMW	pyridine nucleotide-disulfide oxidoreductase
VS_II1248	ENOG4108TEM	pseudouridine methyltransferase
VS_II1250	ENOG4105CND	Glycosyl transferase, family 2
VS_II1260	ENOG4108N3W	hemolysin secretion protein
VS_II1263	ENOG4105C66	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity)
VS_II1264	ENOG4108HIY	periplasmic
VS_II1266	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
VS_II1268	ENOG4108JQ5	ABC transporter
VS_II1271	ENOG4105HEI	LysR family (Transcriptional regulator
VS_II1272	ENOG4108RYK	Nad-dependent epimerase dehydratase
VS_II1274	ENOG4105CHR	reductase
VS_II1276	ENOG410642W	LysR family Transcriptional regulator
VS_II1277	ENOG4105EMU	Dehydrogenase
VS_II1278	ENOG4105EIF	outer membrane protein W
VS_II1279	ENOG4107QQ4	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity)
VS_II1283	ENOG4105S7S	phosphonate abc transporter
VS_II1285	ENOG4105D5T	phosphonate abc transporter
VS_II1288	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
VS_II1289	ENOG4105CQZ	Histidine kinase
VS_II1294	ENOG4107S8C	mandelate racemase muconate lactonizing
VS_II1296	ENOG4105RQF	LysR family Transcriptional regulator
VS_II1298	ENOG4108IUK	alpha amylase, catalytic
VS_II1300	ENOG4105C8Q	Methyl-accepting chemotaxis
VS_II1301	ENOG4105CC0	LysR family Transcriptional regulator
VS_II1303	ENOG4108N3W	hemolysin secretion protein
VS_II1306	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
VS_II1309	ENOG4105E0U	tyrosine-specific transport protein
VS_II1310	ENOG4105K56	Transcriptional regulator
VS_II1311	ENOG4108ZHJ	Organic hydroperoxide resistance protein
VS_II1312	ENOG4108N3W	hemolysin secretion protein
VS_II1315	ENOG4108XFH	Transcriptional regulator
VS_II1316	ENOG4105DM4	PTS System
VS_II1317	ENOG4108YRF	PTS System
VS_II1319	ENOG4106R3P	AraC family transcriptional regulator
VS_II1320	ENOG4105DM4	PTS System
VS_II1321	ENOG4105EIP	mannose-6-phosphate isomerase
VS_II1323	ENOG4105DM4	PTS System
VS_II1324	ENOG4108J59	Extracellular solute-binding protein, family 5
VS_II1328	ENOG4105C4W	S-formylglutathione hydrolase
VS_II1332	ENOG410829K	Lysine exporter protein (Lyse ygga)
VS_II1334	ENOG4105C26	Dehydrogenase
VS_II1336	ENOG4108JU9	GAF modulated sigma54 specific transcriptional regulator Fis family
VS_II1337	ENOG4105C8Q	Methyl-accepting chemotaxis
VS_II1338	ENOG4106P55	Transcriptional regulator
VS_II1339	ENOG4108RXX	maleylacetoacetate isomerase
VS_II1340	ENOG4105VMP	Transcriptional regulator
VS_II1349	ENOG4105DS2	Anaerobic c4-dicarboxylate transporter
VS_II1350	ENOG4107UW8	HAD-superfamily hydrolase subfamily IA variant 3
VS_II1351	ENOG4105EST	Metal Dependent Phosphohydrolase
VS_II1359	ENOG4108ZT1	Transcriptional regulator
VS_II1360	ENOG4108KTG	Membrane protein, drug metabolite transporter
VS_II1365	ENOG4105JQN	Transcriptional regulator
VS_II1366	ENOG4105DWP	Membrane
VS_II1374	ENOG4105YE1	PilZ domain
VS_II1375	ENOG4105DAN	ATP-dependent protease
VS_II1377	ENOG4108JQ5	ABC transporter
VS_II1383	ENOG4105ETE	Transcriptional regulator (LacI family
VS_II1386	ENOG4105E2V	Glycosyltransferase 36
VS_II1389	ENOG4105DRS	transport system, permease
VS_II1392	ENOG41060NJ	transcriptional regulator
VS_II1396	ENOG4105CR8	Transcriptional regulator
VS_II1397	ENOG4105DAA	L-lactate
VS_II1398	ENOG4105DMF	Dehydrogenase
VS_II1402	ENOG410874W	AraC family transcriptional regulator
VS_II1403	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
VS_II1404	ENOG4105C72	UPF0176 protein
VS_II1409	ENOG4105BZU	Histidine kinase
VS_II1411	ENOG4105EUB	pirin domain protein
VS_II1412	ENOG4105NBK	UPF0345 protein
VS_II1415	ENOG4105D3C	The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity)
VS_II1424	ENOG4105WJG	Glutathione
VS_II1426	ENOG4108P2H	Inner membrane protein YjiG
VS_II1427	ENOG41074DU	domain protein
VS_II1428	ENOG4105DN9	Na H antiporter
VS_II1430	ENOG4105K85	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity)
VS_II1431	ENOG4105D03	DNA-3-methyladenine glycosylase II
VS_II1435	ENOG4105CKA	Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity)
VS_II1437	ENOG4108RCM	Nitroreductase
VS_II1439	ENOG4108ESE	uses NADH to detoxify nitric oxide (NO), protecting several 4Fe-4S NO-sensitive enzymes. Has at least 2 reductase partners, only one of which (NorW, flavorubredoxin reductase) has been identified. NO probably binds to the di-iron center
VS_II1440	ENOG4108EQM	faD-dependent pyridine nucleotide-disulfide oxidoreductase
VS_II1442	ENOG4105D6U	Sodium Glutamate Symporter
VS_II1443	ENOG4108YYI	Protein of unknown function (DUF2810)
VS_II1444	ENOG4105EXC	Acyl-transferase
VS_II1446	ENOG4108V5Q	transglutaminase-like protein
VS_II1448	ENOG4105K6V	RNA polymerase
VS_II1449	ENOG4108NIX	Factor ChrR
VS_II1451	ENOG4105CVP	deoxyribo-dipyrimidine photolyase
VS_II1456	ENOG4105CV9	cyclopropane-fatty-acyl-phospholipid synthase
VS_II1462	ENOG4105EMU	Dehydrogenase
VS_II1463	ENOG4105VFU	Rna-binding protein
VS_II1466	ENOG4105C87	Aminotransferase class I and II
VS_II1474	ENOG4105GR3	Histidine kinase
VS_II1478	ENOG4105F27	Major Facilitator
VS_II1479	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
VS_II1481	ENOG4107RAB	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
VS_II1482	ENOG4107QN8	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
VS_II1485	ENOG4107RAN	Peptidase, M16
VS_II1486	ENOG4107RAN	Peptidase, M16
VS_II1487	ENOG4108VAC	response regulator
VS_II1488	ENOG4108HRK	Histidine kinase
VS_II1491	ENOG4105D60	lipoprotein releasing system transmembrane protein
VS_II1494	ENOG4105G2Y	Transcriptional regulator
VS_II1498	ENOG4105MDH	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity)
VS_II1499	ENOG4105EJC	lysr family transcriptional regulator
VS_II1500	ENOG4107RK6	Methyl-accepting chemotaxis
VS_II1501	ENOG4105CF3	3-Hydroxyisobutyrate dehydrogenase
VS_II1504	ENOG4105CDY	transcriptional regulatory protein
VS_II1508	ENOG41090A4	Pterin carbinolamine dehydratase
VS_II1509	ENOG4105MIR	Phenylalanine 4-monooxygenase
VS_II1510	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
VS_II1517	ENOG4105C5B	carbamate kinase
VS_II1518	ENOG4108RXX	maleylacetoacetate isomerase
VS_II1520	ENOG4105F1J	Homogentisate 1,2-dioxygenase
VS_II1521	ENOG4105E6K	4-Hydroxyphenylpyruvate dioxygenase
VS_II1524	ENOG4105BZU	Histidine kinase
VS_II1529	ENOG4108JQ7	(ABC) transporter