locus-tag	class	description
VS_0001	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
VS_0007	COG1126	abc transporter atp-binding protein
VS_0011	COG0592	DNA-directed DNA polymerase activity
VS_0013	COG0187	DNA topoisomerase II activity
VS_0015	COG3977	Valine--pyruvate aminotransferase
VS_0019	COG4964	Belongs to the GSP D family
VS_0030	COG2205	protein histidine kinase activity
VS_0035	COG2119	membrane
VS_0039	COG0604	alcohol dehydrogenase
VS_0042	COG1739	Uncharacterized protein family UPF0029
VS_0043	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
VS_0060	COG0583	DNA-binding transcription factor activity
VS_0062	COG2960	long-chain fatty acid transporting porin activity
VS_0063	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VS_0064	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VS_0065	COG1309	transcriptional regulator
VS_0077	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VS_0082	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VS_0083	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
VS_0085	COG1522	sequence-specific DNA binding
VS_0086	COG5002	protein histidine kinase activity
VS_0086	COG5001	Diguanylate cyclase
VS_0089	COG0697	spore germination
VS_0090	COG0589	response to stress
VS_0091	COG1528	Iron-storage protein
VS_0094	COG2081	HI0933 family
VS_0097	COG1322	Protein conserved in bacteria
VS_0098	COG2226	methyltransferase
VS_0099	COG3165	ubiquinone biosynthetic process from chorismate
VS_0103	COG0805	protein transport
VS_0104	COG0084	hydrolase, TatD family'
VS_0108	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
VS_0108	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
VS_0111	COG0218	Necessary for normal cell division and for the maintenance of normal septation
VS_0116	COG0635	Involved in the biosynthesis of porphyrin-containing compound
VS_0119	COG3852	Histidine kinase
VS_0121	COG0174	glutamine synthetase
VS_0128	COG0456	acetyltransferase
VS_0133	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
VS_0134	COG3031	protein transport across the cell outer membrane
VS_0136	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
VS_0137	COG1459	type II secretion system
VS_0138	COG2165	general secretion pathway protein
VS_0139	COG2165	general secretion pathway protein
VS_0140	COG2165	general secretion pathway protein
VS_0141	COG4795	General secretion pathway protein
VS_0142	COG3156	type II secretion system protein K
VS_0143	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
VS_0144	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
VS_0146	COG1218	3'(2'),5'-bisphosphate nucleotidase
VS_0147	COG0494	nUDIX hydrolase
VS_0148	COG0316	Belongs to the HesB IscA family
VS_0148	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
VS_0153	COG2183	response to ionizing radiation
VS_0155	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
VS_0156	COG0745	RESPONSE REGULATOR receiver
VS_0157	COG2205	protein histidine kinase activity
VS_0158	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
VS_0159	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
VS_0162	COG2252	PERMEase
VS_0165	COG1263	PTS System
VS_0165	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VS_0167	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
VS_0168	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
VS_0169	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
VS_0170	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
VS_0171	COG1454	alcohol dehydrogenase
VS_0173	COG0561	phosphatase activity
VS_0175	COG1278	Cold shock
VS_0176	COG1561	YicC-like family, N-terminal region
VS_0179	COG1560	Kdo2-lipid A biosynthetic process
VS_0181	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
VS_0184	COG0267	Belongs to the bacterial ribosomal protein bL33 family
VS_0188	COG0859	PFAM glycosyl transferase family 9
VS_0189	COG1519	Transferase
VS_0192	COG3642	lipopolysaccharide core region biosynthetic process
VS_0194	COG0859	PFAM glycosyl transferase family 9
VS_0197	COG0438	transferase activity, transferring glycosyl groups
VS_0197	COG4641	Protein conserved in bacteria
VS_0199	COG1560	Kdo2-lipid A biosynthetic process
VS_0203	COG4942	peptidase
VS_0204	COG1045	serine acetyltransferase
VS_0207	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VS_0212	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VS_0213	COG1596	polysaccharide export
VS_0215	COG0489	protein tyrosine kinase activity
VS_0215	COG3206	protein involved in exopolysaccharide biosynthesis
VS_0216	COG2877	3-deoxy-8-phosphooctulonate synthase activity
VS_0217	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
VS_0219	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
VS_0219	COG0517	IMP dehydrogenase activity
VS_0225	COG0110	maltose O-acetyltransferase activity
VS_0226	COG0438	transferase activity, transferring glycosyl groups
VS_0233	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
VS_0236	COG0534	Mate efflux family protein
VS_0237	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
VS_0239	COG0459	protein refolding
VS_0241	COG2199	diguanylate cyclase activity
VS_0241	COG2203	Gaf domain
VS_0242	COG1285	pathogenesis
VS_0243	COG1509	lysine 2,3-aminomutase activity
VS_0247	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
VS_0248	COG1053	succinate dehydrogenase
VS_0251	COG0840	transmembrane signaling receptor activity
VS_0252	COG0471	metal ion transport
VS_0252	COG0490	domain, Protein
VS_0254	COG1162	GTPase activity
VS_0265	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
VS_0266	COG0802	atpase or kinase
VS_0267	COG0860	N-Acetylmuramoyl-L-alanine amidase
VS_0268	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
VS_0271	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
VS_0272	COG0330	HflC and HflK could
VS_0273	COG0330	HflC and HflK could
VS_0274	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
VS_0275	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
VS_0276	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
VS_0277	COG0402	S-adenosylhomocysteine deaminase activity
VS_0278	COG0557	exoribonuclease II activity
VS_0279	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
VS_0284	COG0305	Participates in initiation and elongation during chromosome replication
VS_0287	COG0432	Pfam Uncharacterised protein family UPF0047
VS_0290	COG0735	belongs to the Fur family
VS_0299	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
VS_0316	COG0527	aspartate kinase activity
VS_0318	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
VS_0320	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
VS_0322	COG2197	response regulator
VS_0323	COG0629	single-stranded DNA binding
VS_0324	COG2200	EAL domain
VS_0324	COG2199	diguanylate cyclase activity
VS_0329	COG3409	Peptidoglycan-binding domain 1 protein
VS_0329	COG3267	Type II secretory pathway component ExeA
VS_0331	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
VS_0332	COG1459	type II secretion system
VS_0341	COG1077	Cell shape determining protein MreB Mrl
VS_0342	COG1792	Involved in formation and maintenance of cell shape
VS_0343	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
VS_0344	COG0424	maF-like protein
VS_0345	COG1530	ribonuclease E activity
VS_0346	COG3164	Protein of unknown function
VS_0347	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
VS_0348	COG0312	modulator of DNA gyrase
VS_0349	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
VS_0352	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
VS_0353	COG0589	response to stress
VS_0360	COG0142	geranyltranstransferase activity
VS_0366	COG3610	response to peptide
VS_0371	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
VS_0372	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
VS_0373	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
VS_0374	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
VS_0379	COG0473	3-isopropylmalate dehydrogenase activity
VS_0387	COG1022	Amp-dependent synthetase and ligase
VS_0388	COG0028	Belongs to the TPP enzyme family
VS_0392	COG0469	pyruvate kinase activity
VS_0393	COG1349	DNA-binding transcription factor activity
VS_0394	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
VS_0395	COG2873	o-acetylhomoserine
VS_0397	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
VS_0399	COG1610	YqeY-like protein
VS_0402	COG0596	Alpha beta hydrolase
VS_0404	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
VS_0405	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
VS_0407	COG0617	tRNA 3'-terminal CCA addition
VS_0408	COG3267	Type II secretory pathway component ExeA
VS_0408	COG3409	Peptidoglycan-binding domain 1 protein
VS_0410	COG4991	sh3 domain protein
VS_0411	COG0306	phosphate transporter
VS_0412	COG1392	Phosphate transport regulator
VS_0413	COG3025	triphosphatase activity
VS_0414	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
VS_0416	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
VS_0418	COG1538	Outer membrane efflux protein
VS_0419	COG0494	nUDIX hydrolase
VS_0420	COG3151	Protein conserved in bacteria
VS_0422	COG3150	esterase
VS_0423	COG0187	DNA topoisomerase II activity
VS_0425	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
VS_0427	COG3105	Protein conserved in bacteria
VS_0428	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
VS_0431	COG0723	plastoquinol--plastocyanin reductase activity
VS_0432	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
VS_0433	COG2857	Cytochrome c1
VS_0434	COG0625	glutathione transferase activity
VS_0435	COG2969	positive regulation of protein catabolic process
VS_0436	COG2823	Periplasmic or secreted lipoprotein
VS_0437	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
VS_0440	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
VS_0443	COG3116	cell division
VS_0444	COG0768	penicillin binding
VS_0445	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
VS_0446	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
VS_0449	COG0772	Belongs to the SEDS family
VS_0452	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
VS_0453	COG0849	cell division
VS_0454	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
VS_0459	COG0494	nUDIX hydrolase
VS_0461	COG0505	Belongs to the CarA family
VS_0463	COG0730	response to heat
VS_0464	COG0583	DNA-binding transcription factor activity
VS_0465	COG2860	membrane
VS_0466	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
VS_0470	COG0493	'glutamate synthase
VS_0471	COG0069	glutamate synthase activity
VS_0471	COG0067	glutamate synthase
VS_0471	COG0070	glutamate synthase
VS_0472	COG0067	glutamate synthase
VS_0472	COG0070	glutamate synthase
VS_0472	COG0069	glutamate synthase activity
VS_0474	COG0069	glutamate synthase activity
VS_0474	COG0067	glutamate synthase
VS_0474	COG0070	glutamate synthase
VS_0475	COG1242	4 iron, 4 sulfur cluster binding
VS_0476	COG3706	GGDEF domain
VS_0476	COG5001	Diguanylate cyclase
VS_0476	COG4251	negative regulation of phosphorylation
VS_0476	COG2203	Gaf domain
VS_0477	COG0784	Response regulator, receiver
VS_0477	COG5002	protein histidine kinase activity
VS_0477	COG2198	Histidine kinase
VS_0479	COG0745	RESPONSE REGULATOR receiver
VS_0485	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
VS_0499	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
VS_0501	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
VS_0504	COG1115	amino acid carrier protein
VS_0506	COG0513	Belongs to the DEAD box helicase family
VS_0511	COG0716	FMN binding
VS_0513	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
VS_0514	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
VS_0516	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
VS_0525	COG0730	response to heat
VS_0528	COG0745	RESPONSE REGULATOR receiver
VS_0530	COG1283	sodium-dependent phosphate transmembrane transporter activity
VS_0531	COG0583	DNA-binding transcription factor activity
VS_0532	COG0640	Transcriptional regulator
VS_0534	COG0728	peptidoglycan biosynthetic process
VS_0535	COG0196	riboflavin kinase activity
VS_0538	COG1047	Peptidyl-prolyl cis-trans
VS_0540	COG3279	Response regulator of the LytR AlgR family
VS_0541	COG3275	phosphorelay sensor kinase activity
VS_0542	COG1966	Carbon starvation protein
VS_0545	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
VS_0546	COG1472	Belongs to the glycosyl hydrolase 3 family
VS_0547	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
VS_0548	COG1605	Chorismate mutase
VS_0548	COG0287	Prephenate dehydrogenase
VS_0549	COG0739	heme binding
VS_0551	COG0488	(ABC) transporter
VS_0554	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
VS_0555	COG5001	Diguanylate cyclase
VS_0556	COG1605	Chorismate mutase
VS_0556	COG0077	Prephenate dehydratase
VS_0557	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
VS_0558	COG0741	lytic transglycosylase activity
VS_0559	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VS_0560	COG0564	pseudouridine synthase activity
VS_0574	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
VS_0576	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
VS_0579	COG0745	RESPONSE REGULATOR receiver
VS_0580	COG5002	protein histidine kinase activity
VS_0582	COG0248	Ppx GppA phosphatase
VS_0583	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
VS_0585	COG0573	inorganic phosphate transmembrane transporter activity
VS_0586	COG0581	inorganic phosphate transmembrane transporter activity
VS_0587	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
VS_0588	COG0704	Plays a role in the regulation of phosphate uptake
VS_0593	COG0450	alkyl hydroperoxide reductase
VS_0594	COG0583	DNA-binding transcription factor activity
VS_0595	COG0840	transmembrane signaling receptor activity
VS_0597	COG0517	IMP dehydrogenase activity
VS_0600	COG1862	Preprotein translocase
VS_0601	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VS_0602	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VS_0604	COG0483	inositol monophosphate 1-phosphatase activity
VS_0605	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
VS_0608	COG0822	iron-sulfur transferase activity
VS_0613	COG2975	iron-sulfur cluster assembly
VS_0618	COG1426	Protein conserved in bacteria
VS_0621	COG2976	Protein conserved in bacteria
VS_0622	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VS_0624	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
VS_0625	COG3706	GGDEF domain
VS_0627	COG1570	exodeoxyribonuclease VII activity
VS_0628	COG0516	GMP reductase activity
VS_0628	COG0517	IMP dehydrogenase activity
VS_0632	COG1584	GPR1 FUN34 yaaH family protein
VS_0633	COG1115	amino acid carrier protein
VS_0634	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
VS_0635	COG0204	Acyl-transferase
VS_0640	COG0189	ligase activity
VS_0640	COG4067	protein conserved in archaea
VS_0643	COG2867	negative regulation of translational initiation
VS_0644	COG2914	Belongs to the UPF0125 (RnfH) family
VS_0645	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VS_0646	COG0497	DNA recombination
VS_0650	COG1301	dicarboxylic acid transport
VS_0659	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
VS_0660	COG1253	flavin adenine dinucleotide binding
VS_0661	COG0590	tRNA wobble adenosine to inosine editing
VS_0664	COG0047	phosphoribosylformylglycinamidine synthase activity
VS_0664	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
VS_0666	COG2171	N-acyltransferase activity
VS_0667	COG2095	MarC family integral membrane protein
VS_0670	COG3141	response to X-ray
VS_0673	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
VS_0675	COG1074	ATP-dependent DNA helicase activity
VS_0676	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
VS_0680	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
VS_0681	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
VS_0682	COG2166	iron-sulfur cluster assembly
VS_0683	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
VS_0684	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
VS_0685	COG3248	Nucleoside-binding outer membrane protein
VS_0689	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
VS_0692	COG0271	Belongs to the BolA IbaG family
VS_0694	COG1805	sodium ion transport
VS_0699	COG1477	protein flavinylation
VS_0700	COG2991	Protein conserved in bacteria
VS_0701	COG3706	GGDEF domain
VS_0701	COG0745	RESPONSE REGULATOR receiver
VS_0702	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
VS_0704	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
VS_0706	COG0733	neurotransmitter:sodium symporter activity
VS_0710	COG1686	Belongs to the peptidase S11 family
VS_0711	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
VS_0712	COG0772	Belongs to the SEDS family
VS_0713	COG0768	penicillin binding
VS_0715	COG0799	negative regulation of ribosome biogenesis
VS_0716	COG1466	dna polymerase III delta subunit
VS_0717	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
VS_0719	COG2888	peptidyl-tyrosine sulfation
VS_0720	COG0815	Transfers the fatty acyl group on membrane lipoproteins
VS_0721	COG4535	Mg2 and Co2 transporter CorC
VS_0723	COG1702	phosphate starvation-inducible protein PhoH
VS_0724	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
VS_0725	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VS_0726	COG2706	6-phosphogluconolactonase activity
VS_0746	COG0012	GTP binding
VS_0748	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
VS_0753	COG2890	protein-(glutamine-N5) methyltransferase activity
VS_0754	COG3094	Invasion gene expression up-regulator, SirB
VS_0755	COG2912	Transglutaminase-like superfamily
VS_0758	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
VS_0759	COG1187	pseudouridine synthase activity
VS_0760	COG2840	Smr protein MutS2
VS_0768	COG2217	Heavy metal translocating P-type atpase
VS_0768	COG2608	mercury ion transmembrane transporter activity
VS_0771	COG1028	Short-chain dehydrogenase reductase Sdr
VS_0779	COG2986	histidine ammonia-lyase
VS_0780	COG1216	Glycosyl transferase, family 2
VS_0784	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
VS_0785	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
VS_0798	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
VS_0799	COG0835	chemotaxis
VS_0799	COG0784	Response regulator, receiver
VS_0800	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
VS_0801	COG1815	bacterial-type flagellum-dependent cell motility
VS_0802	COG1558	bacterial-type flagellum-dependent cell motility
VS_0803	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
VS_0804	COG1749	Flagellar hook protein flgE
VS_0805	COG4787	bacterial-type flagellum-dependent cell motility
VS_0806	COG4786	Flagellar basal body rod
VS_0809	COG3951	Flagellar rod assembly protein muramidase FlgJ
VS_0809	COG1705	Flagellar rod assembly protein muramidase FlgJ
VS_0813	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VS_0814	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VS_0816	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
VS_0818	COG1516	flagellar protein fliS
VS_0819	COG2204	response regulator
VS_0820	COG4191	Histidine kinase
VS_0821	COG2204	response regulator
VS_0822	COG1677	Flagellar hook-basal body complex protein FliE
VS_0824	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
VS_0834	COG1987	bacterial-type flagellum assembly
VS_0835	COG1684	flagellar biosynthetic protein fliR
VS_0839	COG0455	bacterial-type flagellum organization
VS_0842	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
VS_0843	COG0643	Histidine kinase
VS_0843	COG2198	Histidine kinase
VS_0844	COG2201	protein-glutamate methylesterase activity
VS_0845	COG1192	Involved in chromosome partitioning
VS_0847	COG0835	chemotaxis
VS_0849	COG4133	protoheme IX ABC transporter activity
VS_0850	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
VS_0852	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
VS_0853	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
VS_0855	COG1138	Cytochrome C-type biogenesis protein
VS_0856	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
VS_0857	COG3088	subunit of a heme lyase
VS_0857	COG4235	cytochrome complex assembly
VS_0858	COG3088	subunit of a heme lyase
VS_0858	COG4235	cytochrome complex assembly
VS_0860	COG2067	long-chain fatty acid transport protein
VS_0861	COG2067	long-chain fatty acid transport protein
VS_0864	COG0183	Belongs to the thiolase family
VS_0865	COG1250	3-hydroxyacyl-CoA dehydrogenase
VS_0865	COG1024	Enoyl-CoA hydratase
VS_0867	COG2062	phosphohistidine phosphatase, SixA
VS_0868	COG2840	Smr protein MutS2
VS_0869	COG2890	protein-(glutamine-N5) methyltransferase activity
VS_0870	COG1280	lysine exporter protein (LysE YggA)
VS_0873	COG0745	RESPONSE REGULATOR receiver
VS_0878	COG3842	ATPase activity
VS_0880	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
VS_0881	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
VS_0882	COG2894	cell division
VS_0885	COG2951	lytic endotransglycosylase activity
VS_0886	COG0583	DNA-binding transcription factor activity
VS_0887	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
VS_0892	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
VS_0893	COG2860	membrane
VS_0894	COG3101	peptidyl-lysine hydroxylation
VS_0896	COG0431	NADPH-dependent FMN reductase
VS_0898	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
VS_0901	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
VS_0905	COG0285	dihydrofolate synthase activity
VS_0906	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
VS_0907	COG1286	toxin biosynthetic process
VS_0908	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
VS_0909	COG0583	DNA-binding transcription factor activity
VS_0910	COG0745	RESPONSE REGULATOR receiver
VS_0913	COG2832	Protein of unknown function (DUF454)
VS_0915	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
VS_0924	COG1785	Belongs to the alkaline phosphatase family
VS_0928	COG2226	methyltransferase
VS_0932	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
VS_0933	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VS_0935	COG3139	Protein of unknown function (DUF1315)
VS_0936	COG0252	asparaginase activity
VS_0937	COG0616	signal peptide processing
VS_0938	COG0446	pyridine nucleotide-disulphide oxidoreductase
VS_0938	COG1902	pentaerythritol trinitrate reductase activity
VS_0939	COG0778	Nitroreductase
VS_0940	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
VS_0943	COG0123	including yeast histone deacetylase and acetoin utilization protein
VS_0945	COG1959	2 iron, 2 sulfur cluster binding
VS_0949	COG3083	sulfuric ester hydrolase activity
VS_0954	COG1757	Na H antiporter
VS_0955	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
VS_0956	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VS_0957	COG2095	MarC family integral membrane protein
VS_0958	COG1012	belongs to the aldehyde dehydrogenase family
VS_0958	COG1454	alcohol dehydrogenase
VS_0962	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
VS_0966	COG2056	Na+-H+ antiporter family
VS_0970	COG0346	lactoylglutathione lyase activity
VS_0971	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
VS_0975	COG4656	Part of a membrane complex involved in electron transport
VS_0976	COG4656	Part of a membrane complex involved in electron transport
VS_0982	COG2204	response regulator
VS_0983	COG2198	Histidine kinase
VS_0984	COG0391	Required for morphogenesis under gluconeogenic growth conditions
VS_0986	COG0521	Mo-molybdopterin cofactor biosynthetic process
VS_0988	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
VS_0989	COG0314	molybdopterin synthase activity
VS_0991	COG0601	transmembrane transport
VS_0992	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VS_0993	COG0444	Belongs to the ABC transporter superfamily
VS_0995	COG0435	Glutathione S-transferase
VS_0997	COG0857	belongs to the CobB CobQ family
VS_0997	COG0280	phosphate acetyltransferase
VS_0998	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
VS_1001	COG3706	GGDEF domain
VS_1002	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
VS_1004	COG0653	protein targeting
VS_1007	COG2186	Transcriptional regulator
VS_1010	COG0489	protein tyrosine kinase activity
VS_1012	COG2982	Protein involved in outer membrane biogenesis
VS_1013	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
VS_1014	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
VS_1015	COG0659	secondary active sulfate transmembrane transporter activity
VS_1016	COG1530	ribonuclease E activity
VS_1017	COG0564	pseudouridine synthase activity
VS_1019	COG1399	metal-binding, possibly nucleic acid-binding protein
VS_1022	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
VS_1027	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
VS_1028	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
VS_1029	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
VS_1031	COG0084	hydrolase, TatD family'
VS_1034	COG0733	neurotransmitter:sodium symporter activity
VS_1036	COG4667	esterase of the alpha-beta hydrolase superfamily
VS_1037	COG0469	pyruvate kinase activity
VS_1038	COG1940	carbohydrate kinase activity
VS_1039	COG0835	chemotaxis
VS_1039	COG0784	Response regulator, receiver
VS_1042	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
VS_1043	COG1028	Short-chain dehydrogenase reductase Sdr
VS_1044	COG0616	signal peptide processing
VS_1045	COG2719	SpoVR family
VS_1046	COG2718	Belongs to the UPF0229 family
VS_1047	COG2766	serine protein kinase
VS_1048	COG3713	MltA-interacting MipA family protein
VS_1050	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
VS_1052	COG1882	Formate acetyltransferase
VS_1056	COG4215	(ABC) transporter
VS_1057	COG4160	amino acid transport
VS_1059	COG0708	Exodeoxyribonuclease III
VS_1060	COG1770	oligopeptidase
VS_1061	COG2814	Major facilitator Superfamily
VS_1063	COG2850	peptidyl-arginine hydroxylation
VS_1067	COG1199	ATP-dependent helicase activity
VS_1072	COG1278	Cold shock
VS_1074	COG0542	response to heat
VS_1075	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
VS_1076	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
VS_1081	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
VS_1082	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
VS_1087	COG3070	regulator of competence-specific genes
VS_1091	COG0745	RESPONSE REGULATOR receiver
VS_1092	COG1434	Gram-negative-bacterium-type cell wall biogenesis
VS_1093	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
VS_1095	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
VS_1096	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
VS_1100	COG0189	ligase activity
VS_1100	COG4067	protein conserved in archaea
VS_1103	COG1801	Protein of unknown function DUF72
VS_1106	COG0840	transmembrane signaling receptor activity
VS_1109	COG1271	oxidase subunit
VS_1110	COG1294	oxidase, subunit
VS_1112	COG0824	Thioesterase
VS_1113	COG0811	peptide transport
VS_1117	COG2885	chlorophyll binding
VS_1118	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
VS_1119	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
VS_1121	COG4774	siderophore transport
VS_1121	COG1629	transport
VS_1122	COG2375	cellular response to nickel ion
VS_1123	COG4592	Periplasmic binding protein
VS_1124	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VS_1125	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VS_1126	COG1120	ATPase activity
VS_1129	COG0784	Response regulator, receiver
VS_1129	COG5002	protein histidine kinase activity
VS_1132	COG0583	DNA-binding transcription factor activity
VS_1137	COG0745	RESPONSE REGULATOR receiver
VS_1138	COG0463	Glycosyl transferase, family 2
VS_1139	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
VS_1141	COG1032	radical SAM domain protein
VS_1144	COG0583	DNA-binding transcription factor activity
VS_1145	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
VS_1147	COG2350	Protein conserved in bacteria
VS_1148	COG1607	acyl-coa hydrolase
VS_1156	COG2203	Gaf domain
VS_1156	COG5001	Diguanylate cyclase
VS_1156	COG4251	negative regulation of phosphorylation
VS_1156	COG3706	GGDEF domain
VS_1157	COG0840	transmembrane signaling receptor activity
VS_1161	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
VS_1162	COG4136	ATPase activity
VS_1163	COG4135	transport system, permease component
VS_1164	COG4134	Bacterial extracellular solute-binding protein
VS_1166	COG3313	Fe-S protein
VS_1172	COG0513	Belongs to the DEAD box helicase family
VS_1173	COG1280	lysine exporter protein (LysE YggA)
VS_1175	COG2866	Carboxypeptidase
VS_1180	COG4176	ABC-type proline glycine betaine transport system permease component
VS_1181	COG2113	Glycine betaine
VS_1183	COG0583	DNA-binding transcription factor activity
VS_1184	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
VS_1185	COG4988	ABC transporter
VS_1186	COG0492	ferredoxin-NADP+ reductase activity
VS_1192	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
VS_1195	COG3706	GGDEF domain
VS_1197	COG3706	GGDEF domain
VS_1197	COG0745	RESPONSE REGULATOR receiver
VS_1199	COG0471	metal ion transport
VS_1201	COG2949	membrane
VS_1202	COG0281	malic enzyme
VS_1203	COG1643	Atp-dependent helicase
VS_1212	COG0247	lactate metabolic process
VS_1212	COG0277	FAD linked oxidase domain protein
VS_1216	COG2986	histidine ammonia-lyase
VS_1218	COG0010	Belongs to the arginase family
VS_1219	COG1228	amidohydrolase
VS_1221	COG4326	sporulation control protein
VS_1228	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
VS_1229	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
VS_1235	COG0488	(ABC) transporter
VS_1236	COG1309	transcriptional regulator
VS_1239	COG0010	Belongs to the arginase family
VS_1241	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
VS_1242	COG0800	Aldolase
VS_1243	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VS_1244	COG1917	Cupin 2, conserved barrel domain protein
VS_1250	COG2186	Transcriptional regulator
VS_1251	COG2186	Transcriptional regulator
VS_1252	COG0517	IMP dehydrogenase activity
VS_1253	COG2176	DNA-directed DNA polymerase activity
VS_1257	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
VS_1262	COG3033	Beta-eliminating lyase
VS_1274	COG0471	metal ion transport
VS_1275	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VS_1275	COG4191	Histidine kinase
VS_1282	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
VS_1284	COG0730	response to heat
VS_1289	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
VS_1290	COG1280	lysine exporter protein (LysE YggA)
VS_1291	COG1115	amino acid carrier protein
VS_1296	COG1115	amino acid carrier protein
VS_1299	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VS_1302	COG3290	protein histidine kinase activity
VS_1303	COG4565	transcriptional regulatory protein
VS_1304	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
VS_1305	COG0363	glucosamine-6-phosphate deaminase activity
VS_1306	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
VS_1308	COG4628	conserved protein (DUF2132)
VS_1316	COG3437	response regulator, receiver
VS_1337	COG3501	Rhs element vgr protein
VS_1338	COG3501	Rhs element vgr protein
VS_1341	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
VS_1343	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
VS_1344	COG0372	Belongs to the citrate synthase family
VS_1345	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
VS_1346	COG2828	Protein conserved in bacteria
VS_1352	COG0561	phosphatase activity
VS_1353	COG0602	queuosine metabolic process
VS_1354	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
VS_1355	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
VS_1362	COG0484	heat shock protein binding
VS_1376	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
VS_1378	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
VS_1381	COG1401	restriction endodeoxyribonuclease activity
VS_1384	COG1196	nuclear chromosome segregation
VS_1390	COG3706	GGDEF domain
VS_1392	COG3047	cAMP biosynthetic process
VS_1392	COG2885	chlorophyll binding
VS_1397	COG1254	Belongs to the acylphosphatase family
VS_1398	COG2920	part of a sulfur-relay system
VS_1399	COG0670	Belongs to the BI1 family
VS_1400	COG1126	abc transporter atp-binding protein
VS_1401	COG0765	amino acid transport
VS_1402	COG4597	amino acid ABC transporter
VS_1403	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VS_1406	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
VS_1407	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
VS_1407	COG0574	Belongs to the PEP-utilizing enzyme family
VS_1410	COG2996	Protein conserved in bacteria
VS_1412	COG3008	intermembrane lipid transfer
VS_1413	COG2995	paraquat-inducible protein a
VS_1414	COG1132	(ABC) transporter
VS_1415	COG1956	GAF domain-containing protein
VS_1419	COG0308	aminopeptidase N
VS_1421	COG2902	Dehydrogenase
VS_1424	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
VS_1424	COG0116	Belongs to the methyltransferase superfamily
VS_1430	COG1067	ATP-dependent peptidase activity
VS_1447	COG2801	Transposase and inactivated derivatives
VS_1455	COG2801	Transposase and inactivated derivatives
VS_1456	COG5002	protein histidine kinase activity
VS_1456	COG0784	Response regulator, receiver
VS_1459	COG3278	Belongs to the heme-copper respiratory oxidase family
VS_1462	COG2010	Cytochrome c
VS_1464	COG2217	Heavy metal translocating P-type atpase
VS_1467	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VS_1468	COG0589	response to stress
VS_1469	COG0037	tRNA processing
VS_1475	COG1176	ABC-type spermidine putrescine transport system, permease component I
VS_1476	COG1177	transmembrane transport
VS_1477	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
VS_1478	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
VS_1480	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
VS_1481	COG0004	ammonium transporteR
VS_1484	COG0437	4 iron, 4 sulfur cluster binding
VS_1485	COG0243	molybdopterin cofactor binding
VS_1485	COG3383	formate dehydrogenase (NAD+) activity
VS_1487	COG3381	protein complex oligomerization
VS_1492	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
VS_1493	COG0488	(ABC) transporter
VS_1494	COG0488	(ABC) transporter
VS_1497	COG4191	Histidine kinase
VS_1498	COG2204	response regulator
VS_1500	COG4662	Binding-protein-dependent transport system inner membrane component
VS_1501	COG3842	ATPase activity
VS_1503	COG0303	'Molybdopterin
VS_1504	COG3706	GGDEF domain
VS_1511	COG0791	NLP P60 protein
VS_1516	COG0307	riboflavin synthase, alpha
VS_1517	COG0534	Mate efflux family protein
VS_1518	COG1793	dna ligase
VS_1520	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
VS_1520	COG2885	chlorophyll binding
VS_1524	COG4176	ABC-type proline glycine betaine transport system permease component
VS_1525	COG3448	diguanylate cyclase activity
VS_1525	COG4175	Glycine betaine
VS_1527	COG2204	response regulator
VS_1528	COG0438	transferase activity, transferring glycosyl groups
VS_1533	COG0438	transferase activity, transferring glycosyl groups
VS_1535	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
VS_1537	COG0583	DNA-binding transcription factor activity
VS_1541	COG1538	Outer membrane efflux protein
VS_1550	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
VS_1552	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
VS_1558	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
VS_1558	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
VS_1559	COG0517	IMP dehydrogenase activity
VS_1561	COG4160	amino acid transport
VS_1562	COG4215	(ABC) transporter
VS_1563	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VS_1564	COG1126	abc transporter atp-binding protein
VS_1567	COG0826	peptidase U32
VS_1570	COG0786	glutamate:sodium symporter activity
VS_1577	COG1028	Short-chain dehydrogenase reductase Sdr
VS_1579	COG0546	phosphoglycolate phosphatase activity
VS_1580	COG0653	protein targeting
VS_1584	COG0346	lactoylglutathione lyase activity
VS_1585	COG1280	lysine exporter protein (LysE YggA)
VS_1590	COG1051	belongs to the nudix hydrolase family
VS_1593	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
VS_1601	COG1187	pseudouridine synthase activity
VS_1604	COG0494	nUDIX hydrolase
VS_1609	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
VS_1611	COG0584	glycerophosphoryl diester phosphodiesterase
VS_1612	COG2271	Major facilitator Superfamily
VS_1618	COG0589	response to stress
VS_1619	COG0415	Belongs to the DNA photolyase family
VS_1620	COG3046	protein related to deoxyribodipyrimidine photolyase
VS_1625	COG0419	ATPase involved in DNA repair
VS_1626	COG0420	3'-5' exonuclease activity
VS_1630	COG0454	-acetyltransferase
VS_1631	COG2199	diguanylate cyclase activity
VS_1633	COG4771	TonB-dependent receptor
VS_1636	COG0840	transmembrane signaling receptor activity
VS_1639	COG3119	arylsulfatase activity
VS_1641	COG0583	DNA-binding transcription factor activity
VS_1648	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
VS_1650	COG0210	DNA helicase
VS_1653	COG0328	RNA-DNA hybrid ribonuclease activity
VS_1655	COG2003	Belongs to the UPF0758 family
VS_1669	COG0582	viral genome integration into host DNA
VS_1673	COG3706	GGDEF domain
VS_1674	COG2195	Cleaves the N-terminal amino acid of tripeptides
VS_1678	COG3063	Type IV pilus biogenesis stability protein PilW
VS_1680	COG1451	nucleotide metabolic process
VS_1682	COG0583	DNA-binding transcription factor activity
VS_1683	COG2814	Major facilitator Superfamily
VS_1687	COG1247	-acetyltransferase
VS_1689	COG1294	oxidase, subunit
VS_1690	COG1271	oxidase subunit
VS_1691	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
VS_1696	COG4139	cobalamin transport
VS_1697	COG2988	succinylglutamate desuccinylase activity
VS_1701	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
VS_1703	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
VS_1704	COG0702	epimerase
VS_1707	COG3122	Protein conserved in bacteria
VS_1708	COG3568	Endonuclease Exonuclease Phosphatase
VS_1713	COG2925	Exonuclease
VS_1715	COG1346	cytolysis
VS_1717	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
VS_1723	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
VS_1726	COG2175	clavaminate synthase activity
VS_1728	COG0840	transmembrane signaling receptor activity
VS_1735	COG0776	regulation of translation
VS_1739	COG1342	Belongs to the UPF0251 family
VS_1743	COG2873	o-acetylhomoserine
VS_1744	COG1522	sequence-specific DNA binding
VS_1748	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
VS_1749	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
VS_1761	COG0596	Alpha beta hydrolase
VS_1765	COG0072	phenylalanine-tRNA ligase activity
VS_1765	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VS_1775	COG1643	Atp-dependent helicase
VS_1781	COG3710	Transcriptional regulator
VS_1785	COG3706	GGDEF domain
VS_1788	COG0443	Heat shock 70 kDa protein
VS_1792	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VS_1793	COG3283	Transcriptional regulator of aromatic amino acids metabolism
VS_1795	COG3106	COG3106 Predicted ATPase
VS_1800	COG5002	protein histidine kinase activity
VS_1800	COG0784	Response regulator, receiver
VS_1802	COG0494	nUDIX hydrolase
VS_1803	COG0814	amino acid
VS_1804	COG1760	l-serine dehydratase
VS_1805	COG0814	amino acid
VS_1806	COG0720	synthase
VS_1807	COG0840	transmembrane signaling receptor activity
VS_1808	COG0659	secondary active sulfate transmembrane transporter activity
VS_1809	COG0017	Asparaginyl-tRNA synthetase
VS_1814	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
VS_1816	COG3437	response regulator, receiver
VS_1816	COG2770	Histidine kinase
VS_1819	COG1448	Aminotransferase
VS_1822	COG2176	DNA-directed DNA polymerase activity
VS_1823	COG2258	MOSC domain
VS_1824	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
VS_1826	COG4191	Histidine kinase
VS_1827	COG2204	response regulator
VS_1829	COG3070	regulator of competence-specific genes
VS_1831	COG2431	L-lysine efflux transmembrane transporter activity
VS_1833	COG0076	glutamate decarboxylase activity
VS_1834	COG1737	Transcriptional regulator
VS_1836	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
VS_1839	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
VS_1850	COG0702	epimerase
VS_1852	COG2814	Major facilitator Superfamily
VS_1854	COG1061	Type III restriction enzyme res subunit
VS_1855	COG5001	Diguanylate cyclase
VS_1855	COG5002	protein histidine kinase activity
VS_1858	COG0642	Histidine kinase
VS_1859	COG0586	Pfam SNARE associated Golgi protein
VS_1869	COG3547	Transposase (IS116 IS110 IS902 family)
VS_1873	COG2801	Transposase and inactivated derivatives
VS_1876	COG0494	nUDIX hydrolase
VS_1880	COG3547	Transposase (IS116 IS110 IS902 family)
VS_1886	COG2732	(Barnase) inhibitor
VS_1891	COG2124	cytochrome p450
VS_1898	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
VS_1899	COG1780	Probably involved in ribonucleotide reductase function
VS_1901	COG0316	Belongs to the HesB IscA family
VS_1902	COG0719	Fe-S assembly protein
VS_1903	COG0396	ATPase activity
VS_1904	COG0719	Fe-S assembly protein
VS_1905	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
VS_1906	COG2166	iron-sulfur cluster assembly
VS_1907	COG0840	transmembrane signaling receptor activity
VS_1908	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
VS_1909	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
VS_1914	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
VS_1917	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
VS_1918	COG3108	Peptidase M15
VS_1919	COG2989	Protein conserved in bacteria
VS_1924	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
VS_1926	COG4235	cytochrome complex assembly
VS_1926	COG3088	subunit of a heme lyase
VS_1928	COG1138	Cytochrome C-type biogenesis protein
VS_1930	COG3301	Polysulphide reductase, NrfD
VS_1931	COG0437	4 iron, 4 sulfur cluster binding
VS_1932	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
VS_1933	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
VS_1934	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VS_1939	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
VS_1940	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
VS_1945	COG0019	diaminopimelate decarboxylase activity
VS_1954	COG0322	excinuclease ABC activity
VS_1955	COG0322	excinuclease ABC activity
VS_1956	COG2197	response regulator
VS_1957	COG0417	DNA replication proofreading
VS_1960	COG3099	Belongs to the UPF0263 family
VS_1962	COG1187	pseudouridine synthase activity
VS_1963	COG0009	L-threonylcarbamoyladenylate synthase
VS_1964	COG0613	PHP domain protein
VS_1966	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
VS_1967	COG0512	Glutamine amidotransferase of anthranilate synthase
VS_1968	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
VS_1969	COG0134	indole-3-glycerol-phosphate synthase activity
VS_1969	COG0135	phosphoribosylanthranilate isomerase activity
VS_1972	COG0330	HflC and HflK could
VS_1974	COG1301	dicarboxylic acid transport
VS_1978	COG0564	pseudouridine synthase activity
VS_1980	COG0733	neurotransmitter:sodium symporter activity
VS_1982	COG0626	cystathionine gamma-synthase activity
VS_1985	COG2818	Glycosylase
VS_1988	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VS_1989	COG1983	PspC domain protein
VS_1991	COG1842	Phage shock protein A
VS_1992	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
VS_1993	COG4166	transmembrane transport
VS_1994	COG4168	peptide transport system, permease
VS_1995	COG4171	peptide transport system, permease
VS_1997	COG4172	Belongs to the ABC transporter superfamily
VS_2001	COG1227	inorganic diphosphatase activity
VS_2003	COG0243	molybdopterin cofactor binding
VS_2004	COG3005	denitrification pathway
VS_2005	COG4459	periplasmic nitrate reductase
VS_2006	COG0390	transport system, permease component
VS_2008	COG2116	formate transmembrane transporter activity
VS_2015	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
VS_2017	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
VS_2018	COG3012	SEC-C Motif Domain Protein
VS_2019	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
VS_2019	COG0140	phosphoribosyl-ATP diphosphatase activity
VS_2021	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
VS_2022	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
VS_2023	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
VS_2023	COG0131	Imidazoleglycerol-phosphate dehydratase
VS_2024	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
VS_2027	COG1757	Na H antiporter
VS_2029	COG2916	Histone family protein nucleoid-structuring protein H-NS
VS_2030	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VS_2034	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
VS_2041	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
VS_2044	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
VS_2046	COG1674	ftsk spoiiie
VS_2047	COG1522	sequence-specific DNA binding
VS_2048	COG0686	Belongs to the AlaDH PNT family
VS_2050	COG0583	DNA-binding transcription factor activity
VS_2054	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
VS_2055	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
VS_2057	COG0539	negative regulation of cytoplasmic translation
VS_2059	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
VS_2062	COG1132	(ABC) transporter
VS_2063	COG2333	competence protein COMEC
VS_2063	COG0658	competence protein
VS_2065	COG4591	ABC-type transport system involved in lipoprotein release permease component
VS_2066	COG1136	(ABC) transporter
VS_2067	COG4591	ABC-type transport system involved in lipoprotein release permease component
VS_2069	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
VS_2072	COG1252	NADH dehydrogenase
VS_2079	COG0537	adenosine 5'-monophosphoramidase activity
VS_2085	COG0517	IMP dehydrogenase activity
VS_2090	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
VS_2092	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
VS_2095	COG1902	pentaerythritol trinitrate reductase activity
VS_2096	COG0346	lactoylglutathione lyase activity
VS_2101	COG2015	COG2015, Alkyl sulfatase and related hydrolases
VS_2103	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VS_2105	COG1309	transcriptional regulator
VS_2106	COG0583	DNA-binding transcription factor activity
VS_2109	COG3040	lipid binding
VS_2110	COG1574	metal-dependent hydrolase with the TIM-barrel fold
VS_2112	COG1120	ATPase activity
VS_2113	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
VS_2119	COG3118	belongs to the thioredoxin family
VS_2120	COG4232	protein-disulfide reductase activity
VS_2124	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
VS_2126	COG0450	alkyl hydroperoxide reductase
VS_2128	COG1280	lysine exporter protein (LysE YggA)
VS_2129	COG1522	sequence-specific DNA binding
VS_2133	COG0789	Transcriptional regulator
VS_2135	COG0583	DNA-binding transcription factor activity
VS_2138	COG0069	glutamate synthase activity
VS_2138	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
VS_2145	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
VS_2151	COG1216	Glycosyl transferase, family 2
VS_2151	COG0463	Glycosyl transferase, family 2
VS_2152	COG0438	transferase activity, transferring glycosyl groups
VS_2153	COG0328	RNA-DNA hybrid ribonuclease activity
VS_2153	COG3341	Caulimovirus viroplasmin
VS_2161	COG4106	trans-aconitate 2-methyltransferase activity
VS_2165	COG3126	Type III secretion system lipoprotein chaperone (YscW)
VS_2166	COG1946	Acyl-CoA thioesterase
VS_2168	COG1522	sequence-specific DNA binding
VS_2171	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VS_2183	COG2855	membrane
VS_2186	COG2190	(PTS) system
VS_2186	COG1263	PTS System
VS_2186	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VS_2188	COG1441	menaquinone biosynthetic process
VS_2189	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
VS_2190	COG2267	carboxylic ester hydrolase activity
VS_2192	COG1169	isochorismate synthase
VS_2193	COG0436	Aminotransferase
VS_2196	COG0232	Belongs to the dGTPase family. Type 2 subfamily
VS_2199	COG1555	photosystem II stabilization
VS_2200	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
VS_2201	COG0776	regulation of translation
VS_2203	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
VS_2208	COG2204	response regulator
VS_2210	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
VS_2211	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
VS_2212	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
VS_2215	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
VS_2215	COG3321	synthase
VS_2218	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
VS_2218	COG2070	2-Nitropropane dioxygenase
VS_2219	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
VS_2220	COG0318	PFAM AMP-dependent synthetase and ligase
VS_2221	COG2267	carboxylic ester hydrolase activity
VS_2225	COG1214	PFAM Peptidase M22, glycoprotease
VS_2226	COG1199	ATP-dependent helicase activity
VS_2228	COG0788	formyltetrahydrofolate deformylase activity
VS_2229	COG3102	Protein conserved in bacteria
VS_2234	COG1918	ferrous iron import across plasma membrane
VS_2237	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
VS_2238	COG1121	(ABC) transporter
VS_2239	COG1108	ABC-type Mn2 Zn2 transport systems permease components
VS_2242	COG0508	dehydrogenase complex catalyzes the overall conversion of
VS_2243	COG0567	Dehydrogenase, E1 component
VS_2246	COG1053	succinate dehydrogenase
VS_2247	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
VS_2248	COG2009	succinate dehydrogenase
VS_2249	COG0372	Belongs to the citrate synthase family
VS_2250	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
VS_2252	COG0033	Phosphoglucomutase
VS_2254	COG0596	Alpha beta hydrolase
VS_2260	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VS_2260	COG1263	PTS System
VS_2260	COG2190	(PTS) system
VS_2261	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
VS_2262	COG1846	Transcriptional regulator
VS_2262	COG1940	carbohydrate kinase activity
VS_2263	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
VS_2263	COG4651	solute:proton antiporter activity
VS_2264	COG0367	asparagine synthase
VS_2265	COG0250	Participates in transcription elongation, termination and antitermination
VS_2266	COG3104	oligopeptide transport
VS_2270	COG3710	Transcriptional regulator
VS_2273	COG0622	Phosphoesterase
VS_2278	COG1090	epimerase
VS_2279	COG0300	oxidoreductase activity
VS_2280	COG3118	belongs to the thioredoxin family
VS_2281	COG0330	HflC and HflK could
VS_2283	COG0789	Transcriptional regulator
VS_2289	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
VS_2290	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
VS_2292	COG2190	(PTS) system
VS_2293	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VS_2294	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VS_2295	COG2837	iron assimilation
VS_2300	COG1393	Belongs to the ArsC family
VS_2305	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
VS_2307	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
VS_2311	COG4783	chaperone-mediated protein folding
VS_2312	COG1393	Belongs to the ArsC family
VS_2316	COG2233	PERMEase
VS_2317	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
VS_2319	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
VS_2320	COG0121	glutamine amidotransferase
VS_2321	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
VS_2322	COG1960	acyl-CoA dehydrogenase activity
VS_2324	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
VS_2328	COG2226	methyltransferase
VS_2330	COG1388	LysM domain
VS_2330	COG0741	lytic transglycosylase activity
VS_2332	COG3021	interspecies interaction between organisms
VS_2333	COG0347	Belongs to the P(II) protein family
VS_2337	COG0587	DNA-directed DNA polymerase activity
VS_2342	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VS_2343	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
VS_2345	COG0750	zinc metalloprotease
VS_2348	COG0575	Belongs to the CDS family
VS_2349	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
VS_2350	COG0233	cytoplasmic translational termination
VS_2351	COG0528	UMP kinase activity
VS_2353	COG0052	Belongs to the universal ribosomal protein uS2 family
VS_2354	COG0024	Methionine aminopeptidase
VS_2357	COG0564	pseudouridine synthase activity
VS_2358	COG3098	single-species biofilm formation
VS_2365	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
VS_2367	COG1720	tRNA m6t6A37 methyltransferase activity
VS_2373	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
VS_2374	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
VS_2377	COG0366	Alpha amylase catalytic
VS_2378	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VS_2378	COG1263	PTS System
VS_2379	COG1609	Transcriptional regulator
VS_2381	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
VS_2382	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
VS_2383	COG2011	ABC-type metal ion transport system permease component
VS_2384	COG1464	Belongs to the NlpA lipoprotein family
VS_2388	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
VS_2392	COG3706	GGDEF domain
VS_2392	COG0745	RESPONSE REGULATOR receiver
VS_2393	COG1611	Belongs to the LOG family
VS_2399	COG0583	DNA-binding transcription factor activity
VS_2403	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
VS_2405	COG0142	geranyltranstransferase activity
VS_2407	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
VS_2408	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
VS_2413	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
VS_2413	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
VS_2421	COG2252	PERMEase
VS_2422	COG2195	Cleaves the N-terminal amino acid of tripeptides
VS_2428	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
VS_2429	COG0583	DNA-binding transcription factor activity
VS_2430	COG2059	Chromate
VS_2431	COG2226	methyltransferase
VS_2443	COG4964	Belongs to the GSP D family
VS_2450	COG1022	Amp-dependent synthetase and ligase
VS_2452	COG0583	DNA-binding transcription factor activity
VS_2453	COG4628	conserved protein (DUF2132)
VS_2454	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
VS_2456	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
VS_2458	COG0560	Phosphoserine phosphatase
VS_2460	COG0813	purine-nucleoside phosphorylase activity
VS_2461	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
VS_2464	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
VS_2465	COG0084	hydrolase, TatD family'
VS_2470	COG3153	acetyltransferase
VS_2475	COG0534	Mate efflux family protein
VS_2483	COG0195	Participates in both transcription termination and antitermination
VS_2487	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
VS_2489	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
VS_2490	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
VS_2492	COG1534	Rna-binding protein
VS_2493	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
VS_2495	COG2027	D-alanyl-D-alanine carboxypeptidase
VS_2496	COG2239	Acts as a magnesium transporter
VS_2497	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
VS_2498	COG0739	heme binding
VS_2503	COG0628	permease
VS_2504	COG2813	Specifically methylates the guanine in position
VS_2506	COG0747	negative chemotaxis
VS_2508	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VS_2509	COG0444	Belongs to the ABC transporter superfamily
VS_2510	COG4608	Belongs to the ABC transporter superfamily
VS_2512	COG2971	BadF BadG BcrA BcrD
VS_2515	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
VS_2516	COG3842	ATPase activity
VS_2518	COG1840	ABC-type Fe3 transport system, periplasmic component
VS_2519	COG0004	ammonium transporteR
VS_2522	COG1049	propionate catabolic process, 2-methylcitrate cycle
VS_2523	COG1752	Esterase of the alpha-beta hydrolase superfamily
VS_2524	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
VS_2526	COG1643	Atp-dependent helicase
VS_2528	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
VS_2531	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
VS_2534	COG0842	Transport permease protein
VS_2535	COG1131	(ABC) transporter
VS_2536	COG0659	secondary active sulfate transmembrane transporter activity
VS_2537	COG0288	reversible hydration of carbon dioxide
VS_2540	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VS_2541	COG0508	dehydrogenase complex catalyzes the overall conversion of
VS_2542	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
VS_2543	COG2186	Transcriptional regulator
VS_2546	COG0157	Belongs to the NadC ModD family
VS_2548	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
VS_2549	COG1459	type II secretion system
VS_2551	COG0237	dephospho-CoA kinase activity
VS_2552	COG0237	dephospho-CoA kinase activity
VS_2554	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
VS_2559	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
VS_2560	COG4137	Cytochrome C assembly protein
VS_2561	COG4536	flavin adenine dinucleotide binding
VS_2565	COG0612	Peptidase, M16
VS_2566	COG1238	metal cluster binding
VS_2567	COG1064	alcohol dehydrogenase
VS_2568	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
VS_2569	COG5016	pyruvate
VS_2569	COG0511	ligase activity, forming carbon-carbon bonds
VS_2582	COG0527	aspartate kinase activity
VS_2586	COG3842	ATPase activity
VS_2588	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VS_2590	COG2182	Extracellular solute-binding protein
VS_2591	COG1175	transmembrane transport
VS_2592	COG3833	ABC-type maltose transport systems, permease component
VS_2596	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
VS_2597	COG1546	Belongs to the CinA family
VS_2599	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
VS_2602	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
VS_2603	COG0585	pseudouridine synthase activity
VS_2607	COG0148	phosphopyruvate hydratase activity
VS_2610	COG3956	TIGRFAM MazG family protein
VS_2611	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
VS_2614	COG4999	Histidine kinase
VS_2614	COG3850	Histidine kinase
VS_2614	COG3437	response regulator, receiver
VS_2614	COG2205	protein histidine kinase activity
VS_2620	COG0681	Belongs to the peptidase S26 family
VS_2625	COG1595	DNA-templated transcription, initiation
VS_2627	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
VS_2629	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
VS_2633	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VS_2634	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VS_2636	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
VS_2638	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
VS_2640	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
VS_2643	COG1279	arginine transmembrane transporter activity
VS_2644	COG0668	transmembrane transport
VS_2645	COG0191	fructose-bisphosphate aldolase activity
VS_2650	COG1653	transport
VS_2651	COG0642	Histidine kinase
VS_2652	COG0745	RESPONSE REGULATOR receiver
VS_2654	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
VS_2658	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VS_2659	COG0588	phosphoglycerate mutase activity
VS_2661	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
VS_2669	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
VS_2674	COG2356	endonuclease I
VS_2677	COG1385	rRNA (uridine-N3-)-methyltransferase activity
VS_2678	COG0189	ligase activity
VS_2680	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
VS_2683	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
VS_2684	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
VS_2685	COG0762	integral membrane protein
VS_2689	COG0635	Involved in the biosynthesis of porphyrin-containing compound
VS_2694	COG0741	lytic transglycosylase activity
VS_2723	COG3437	response regulator, receiver
VS_2727	COG0795	lipopolysaccharide-transporting ATPase activity
VS_2728	COG0795	lipopolysaccharide-transporting ATPase activity
VS_2730	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
VS_2731	COG2927	DNA polymerase III (CHI subunit)
VS_2732	COG0525	valine-tRNA ligase activity
VS_2735	COG0456	acetyltransferase
VS_2741	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
VS_2742	COG0251	oxidation-reduction process
VS_2743	COG0204	Acyl-transferase
VS_2745	COG5007	Belongs to the BolA IbaG family
VS_2747	COG2854	intermembrane phospholipid transfer
VS_2748	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
VS_2749	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
VS_2750	COG1127	ABC transporter
VS_2752	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
VS_2752	COG0517	IMP dehydrogenase activity
VS_2753	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
VS_2755	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
VS_2756	COG1137	ATPase activity
VS_2758	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
VS_2759	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
VS_2761	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
VS_2762	COG2239	Acts as a magnesium transporter
VS_2763	COG0312	modulator of DNA gyrase
VS_2765	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
VS_2766	COG1178	ABC-type Fe3 transport system permease component
VS_2767	COG4143	(ABC) transporter
VS_2769	COG0163	prenyltransferase activity
VS_2770	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
VS_2773	COG2105	PFAM AIG2 family protein
VS_2774	COG2911	Protein conserved in bacteria
VS_2775	COG0729	surface antigen
VS_2776	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VS_2779	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
VS_2786	COG0529	Catalyzes the synthesis of activated sulfate
VS_2787	COG0471	metal ion transport
VS_2787	COG3273	potassium ion transport
VS_2799	COG2153	protein acetylation
VS_2801	COG3266	domain, Protein
VS_2801	COG3061	Opacity-associated protein A
VS_2803	COG0545	Peptidyl-prolyl cis-trans isomerase
VS_2810	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
VS_2811	COG0201	protein transport
VS_2818	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
VS_2821	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
VS_2833	COG0051	transcription antitermination factor activity, RNA binding
VS_2835	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
VS_2839	COG2923	Belongs to the DsrF TusC family
VS_2840	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
VS_2841	COG2964	Protein conserved in bacteria
VS_2842	COG0545	Peptidyl-prolyl cis-trans isomerase
VS_2845	COG1446	asparaginase
VS_2846	COG1047	Peptidyl-prolyl cis-trans
VS_2850	COG0488	(ABC) transporter
VS_2852	COG0429	hydrolase of the alpha beta-hydrolase fold
VS_2854	COG3954	Phosphoribulokinase
VS_2855	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VS_2861	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
VS_2862	COG0512	Glutamine amidotransferase of anthranilate synthase
VS_2866	COG0180	Tryptophanyl-tRNA synthetase
VS_2867	COG0546	phosphoglycolate phosphatase activity
VS_2868	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
VS_2869	COG0338	D12 class N6 adenine-specific DNA methyltransferase
VS_2878	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
VS_2880	COG0678	peroxiredoxin activity
VS_2880	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
VS_2881	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VS_2882	COG0251	oxidation-reduction process
VS_2885	COG0165	Argininosuccinate lyase
VS_2885	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
VS_2888	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
VS_2892	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
VS_2893	COG0527	aspartate kinase activity
VS_2893	COG0460	homoserine dehydrogenase
VS_2894	COG0626	cystathionine gamma-synthase activity
VS_2896	COG0281	malic enzyme
VS_2898	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
VS_2899	COG1609	Transcriptional regulator
VS_2903	COG1575	Belongs to the MenA family. Type 1 subfamily
VS_2904	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
VS_2906	COG1494	fructose-1,6-bisphosphatase
VS_2909	COG3152	Membrane
VS_2914	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
VS_2916	COG0745	RESPONSE REGULATOR receiver
VS_2917	COG2205	protein histidine kinase activity
VS_2919	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
VS_2921	COG1027	Aspartate ammonia-lyase
VS_2922	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
VS_2923	COG1288	antiporter activity
VS_2926	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
VS_2927	COG0540	Belongs to the ATCase OTCase family
VS_2928	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
VS_2929	COG1438	arginine binding
VS_2930	COG4232	protein-disulfide reductase activity
VS_2932	COG3263	regulation of cellular component size
VS_2935	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
VS_2938	COG0784	Response regulator, receiver
VS_2938	COG2198	Histidine kinase
VS_2938	COG2205	protein histidine kinase activity
VS_2939	COG2814	Major facilitator Superfamily
VS_2942	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
VS_2943	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
VS_2944	COG0511	ligase activity, forming carbon-carbon bonds
VS_2945	COG0439	Biotin carboxylase
VS_2947	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
VS_2949	COG3706	GGDEF domain
VS_2950	COG0789	Transcriptional regulator
VS_2952	COG0151	Belongs to the GarS family
VS_2955	COG1253	flavin adenine dinucleotide binding
VS_2956	COG3068	Protein conserved in bacteria
VS_2958	COG1573	uracil-dna glycosylase
VS_2959	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
VS_2961	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
VS_2965	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
VS_2970	COG0250	Participates in transcription elongation, termination and antitermination
VS_2971	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
VS_2978	COG1072	(Pantothenic acid kinase))
VS_2980	COG0812	UDP-N-acetylmuramate dehydrogenase activity
VS_2982	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
VS_2983	COG3335	DDE superfamily endonuclease
VS_2996	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
VS_2998	COG4206	TonB-dependent receptor
VS_3004	COG0534	Mate efflux family protein
VS_3005	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
VS_3007	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
VS_3013	COG3161	chorismate lyase activity
VS_3015	COG1580	Controls the rotational direction of flagella during chemotaxis
VS_3016	COG0705	Rhomboid family
VS_3019	COG2177	Part of the ABC transporter FtsEX involved in
VS_3020	COG2884	Cell division ATP-binding protein ftsE
VS_3021	COG0552	protein localization to endoplasmic reticulum
VS_3021	COG0552	protein localization to endoplasmic reticulum
VS_3023	COG0742	ribosomal rna small subunit methyltransferase
VS_3025	COG2095	MarC family integral membrane protein
VS_3033	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
VS_3034	COG0640	Transcriptional regulator
VS_3035	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
VS_3036	COG1280	lysine exporter protein (LysE YggA)
VS_3037	COG2267	carboxylic ester hydrolase activity
VS_3038	COG0561	phosphatase activity
VS_3042	COG3287	FIST C domain
VS_3042	COG2199	diguanylate cyclase activity
VS_3042	COG2200	EAL domain
VS_3043	COG2199	diguanylate cyclase activity
VS_3043	COG2200	EAL domain
VS_3043	COG3287	FIST C domain
VS_3044	COG1011	Hydrolase
VS_3048	COG0019	diaminopimelate decarboxylase activity
VS_3051	COG3072	Adenylate cyclase
VS_3053	COG1587	Uroporphyrinogen-III synthase
VS_3054	COG2959	enzyme of heme biosynthesis
VS_3055	COG3071	HemY protein
VS_3069	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
VS_3071	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
VS_3072	COG3118	belongs to the thioredoxin family
VS_3075	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
VS_3077	COG0514	ATP-dependent DNA helicase (RecQ)
VS_3078	COG2962	Rard protein
VS_3080	COG1280	lysine exporter protein (LysE YggA)
VS_3081	COG0405	Gamma-glutamyltransferase
VS_3084	COG0210	DNA helicase
VS_3086	COG3220	belongs to the UPF0276 family
VS_3091	COG0583	DNA-binding transcription factor activity
VS_3092	COG0006	proline dipeptidase activity
VS_3092	COG0006	proline dipeptidase activity
VS_3095	COG2104	thiamine diphosphate biosynthetic process
VS_3096	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
VS_3097	COG0352	thiamine-phosphate diphosphorylase activity
VS_3101	COG2132	Multicopper oxidase
VS_3115	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
VS_3119	COG0009	L-threonylcarbamoyladenylate synthase
VS_3120	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
VS_3121	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
VS_3122	COG0551	DNA topoisomerase type I activity
VS_3124	COG0758	DNA mediated transformation
VS_3126	COG0242	peptide deformylase activity
VS_3128	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
VS_3128	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
VS_3129	COG0569	domain protein
VS_3131	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
VS_3133	COG1272	protein, Hemolysin III
VS_3134	COG4326	sporulation control protein
VS_3136	COG3084	Protein conserved in bacteria
VS_3139	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
VS_3140	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
VS_3142	COG0606	chelatase, subunit chli
VS_3144	COG3978	acetolactate synthase activity
VS_3145	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
VS_3148	COG0583	DNA-binding transcription factor activity
VS_3149	COG2814	Major facilitator Superfamily
VS_3151	COG0355	proton-transporting ATP synthase activity, rotational mechanism
VS_3152	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
VS_3153	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
VS_3154	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
VS_3156	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
VS_3158	COG0356	it plays a direct role in the translocation of protons across the membrane
VS_3159	COG3312	ion transport
VS_3160	COG1475	DNA binding
VS_3161	COG1192	Involved in chromosome partitioning
VS_II0003	COG1444	tRNA N-acetyltransferase activity
VS_II0014	COG1262	PFAM Formylglycine-generating sulfatase enzyme
VS_II0021	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
VS_II0025	COG4399	Belongs to the UPF0754 family
VS_II0026	COG1132	(ABC) transporter
VS_II0031	COG2194	sulfuric ester hydrolase activity
VS_II0036	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
VS_II0038	COG4145	pantothenate transmembrane transporter activity
VS_II0039	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VS_II0040	COG0800	Aldolase
VS_II0043	COG2205	protein histidine kinase activity
VS_II0044	COG0745	RESPONSE REGULATOR receiver
VS_II0045	COG5001	Diguanylate cyclase
VS_II0045	COG3300	MHYT domain
VS_II0049	COG1522	sequence-specific DNA binding
VS_II0051	COG1473	amidohydrolase
VS_II0052	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
VS_II0054	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
VS_II0061	COG0517	IMP dehydrogenase activity
VS_II0061	COG4175	Glycine betaine
VS_II0062	COG1846	Transcriptional regulator
VS_II0066	COG0456	acetyltransferase
VS_II0067	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
VS_II0069	COG0527	aspartate kinase activity
VS_II0072	COG0110	maltose O-acetyltransferase activity
VS_II0092	COG2015	COG2015, Alkyl sulfatase and related hydrolases
VS_II0095	COG0346	lactoylglutathione lyase activity
VS_II0097	COG2723	6-phospho-beta-galactosidase activity
VS_II0098	COG1609	Transcriptional regulator
VS_II0099	COG0110	maltose O-acetyltransferase activity
VS_II0100	COG2814	Major facilitator Superfamily
VS_II0101	COG0583	DNA-binding transcription factor activity
VS_II0105	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
VS_II0107	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
VS_II0113	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
VS_II0114	COG1349	DNA-binding transcription factor activity
VS_II0116	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
VS_II0118	COG0583	DNA-binding transcription factor activity
VS_II0119	COG0798	PFAM Bile acid sodium symporter
VS_II0121	COG0561	phosphatase activity
VS_II0123	COG3214	Protein conserved in bacteria
VS_II0124	COG0583	DNA-binding transcription factor activity
VS_II0130	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
VS_II0131	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
VS_II0136	COG3623	hexulose-6-phosphate isomerase
VS_II0137	COG1414	Transcriptional regulator
VS_II0138	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
VS_II0141	COG0561	phosphatase activity
VS_II0143	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
VS_II0144	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
VS_II0145	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
VS_II0147	COG1929	Belongs to the glycerate kinase type-1 family
VS_II0148	COG0753	catalase activity
VS_II0149	COG4667	esterase of the alpha-beta hydrolase superfamily
VS_II0150	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
VS_II0152	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
VS_II0153	COG0204	Acyl-transferase
VS_II0155	COG2384	SAM-dependent methyltransferase
VS_II0163	COG0366	Alpha amylase catalytic
VS_II0175	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
VS_II0177	COG1162	GTPase activity
VS_II0179	COG1999	signal sequence binding
VS_II0184	COG0058	SHG alpha-glucan phosphorylase activity
VS_II0185	COG1640	4-alpha-glucanotransferase
VS_II0186	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
VS_II0188	COG1122	ATPase activity
VS_II0190	COG1566	PFAM secretion protein HlyD family protein
VS_II0193	COG3706	GGDEF domain
VS_II0197	COG0813	purine-nucleoside phosphorylase activity
VS_II0198	COG1376	ErfK ybiS ycfS ynhG family protein
VS_II0198	COG1388	LysM domain
VS_II0200	COG0513	Belongs to the DEAD box helicase family
VS_II0201	COG3240	lipase activity
VS_II0202	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
VS_II0204	COG0840	transmembrane signaling receptor activity
VS_II0205	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
VS_II0206	COG0573	inorganic phosphate transmembrane transporter activity
VS_II0207	COG0581	inorganic phosphate transmembrane transporter activity
VS_II0211	COG2304	oxidoreductase activity
VS_II0212	COG2304	oxidoreductase activity
VS_II0215	COG0714	Associated with various cellular activities
VS_II0216	COG0840	transmembrane signaling receptor activity
VS_II0219	COG3842	ATPase activity
VS_II0221	COG1175	transmembrane transport
VS_II0231	COG0668	transmembrane transport
VS_II0232	COG0583	DNA-binding transcription factor activity
VS_II0236	COG2239	Acts as a magnesium transporter
VS_II0239	COG0387	Pfam Sodium calcium exchanger
VS_II0240	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VS_II0241	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VS_II0243	COG2356	endonuclease I
VS_II0247	COG1136	(ABC) transporter
VS_II0248	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VS_II0249	COG5001	Diguanylate cyclase
VS_II0249	COG3300	MHYT domain
VS_II0252	COG1032	radical SAM domain protein
VS_II0267	COG1012	belongs to the aldehyde dehydrogenase family
VS_II0269	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
VS_II0271	COG3706	GGDEF domain
VS_II0271	COG0745	RESPONSE REGULATOR receiver
VS_II0274	COG3217	Mosc domain protein beta barrel domain protein
VS_II0274	COG0633	Ferredoxin
VS_II0284	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
VS_II0285	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VS_II0287	COG0848	biopolymer transport protein
VS_II0288	COG0811	peptide transport
VS_II0289	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
VS_II0291	COG3721	Heme iron utilization protein
VS_II0292	COG0748	coenzyme F420 binding
VS_II0293	COG0784	Response regulator, receiver
VS_II0293	COG0835	chemotaxis
VS_II0294	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
VS_II0295	COG0366	Alpha amylase catalytic
VS_II0302	COG0739	heme binding
VS_II0303	COG5001	Diguanylate cyclase
VS_II0304	COG0583	DNA-binding transcription factor activity
VS_II0305	COG2814	Major facilitator Superfamily
VS_II0309	COG0697	spore germination
VS_II0310	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
VS_II0312	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
VS_II0313	COG3037	sugar-specific permease SgaT UlaA
VS_II0316	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
VS_II0321	COG0513	Belongs to the DEAD box helicase family
VS_II0325	COG3706	GGDEF domain
VS_II0326	COG1278	Cold shock
VS_II0327	COG0402	S-adenosylhomocysteine deaminase activity
VS_II0328	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
VS_II0329	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
VS_II0335	COG4413	Urea transporter
VS_II0338	COG0531	amino acid
VS_II0341	COG1280	lysine exporter protein (LysE YggA)
VS_II0345	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
VS_II0354	COG2827	Endonuclease containing a URI domain
VS_II0360	COG0443	Heat shock 70 kDa protein
VS_II0362	COG0179	Fumarylacetoacetate (FAA) hydrolase
VS_II0363	COG1280	lysine exporter protein (LysE YggA)
VS_II0364	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
VS_II0366	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
VS_II0368	COG1845	cytochrome c oxidase, subunit III
VS_II0371	COG1612	heme a metabolic process
VS_II0373	COG0109	protoheme IX farnesyltransferase activity
VS_II0376	COG3530	Putative quorum-sensing-regulated virulence factor
VS_II0381	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
VS_II0382	COG2944	sequence-specific DNA binding
VS_II0387	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
VS_II0388	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
VS_II0390	COG0668	transmembrane transport
VS_II0391	COG0569	domain protein
VS_II0392	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
VS_II0393	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VS_II0393	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VS_II0394	COG1765	OsmC-like protein
VS_II0395	COG2885	chlorophyll binding
VS_II0399	COG1840	ABC-type Fe3 transport system, periplasmic component
VS_II0400	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
VS_II0401	COG3842	ATPase activity
VS_II0405	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
VS_II0407	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
VS_II0408	COG3265	gluconokinase activity
VS_II0409	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
VS_II0411	COG1609	Transcriptional regulator
VS_II0414	COG1760	l-serine dehydratase
VS_II0417	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
VS_II0421	COG1132	(ABC) transporter
VS_II0422	COG1132	(ABC) transporter
VS_II0424	COG0739	heme binding
VS_II0425	COG0393	Putative heavy-metal-binding
VS_II0428	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
VS_II0433	COG0346	lactoylglutathione lyase activity
VS_II0435	COG2211	Major facilitator Superfamily
VS_II0436	COG0156	8-amino-7-oxononanoate synthase activity
VS_II0440	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
VS_II0440	COG0475	glutathione-regulated potassium exporter activity
VS_II0441	COG2249	NAD(P)H dehydrogenase (quinone) activity
VS_II0445	COG1454	alcohol dehydrogenase
VS_II0447	COG1011	Hydrolase
VS_II0449	COG3706	GGDEF domain
VS_II0449	COG5001	Diguanylate cyclase
VS_II0449	COG2203	Gaf domain
VS_II0449	COG4251	negative regulation of phosphorylation
VS_II0453	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
VS_II0454	COG1328	CTP reductase activity
VS_II0455	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
VS_II0456	COG0583	DNA-binding transcription factor activity
VS_II0460	COG1289	transmembrane transporter activity
VS_II0461	COG0210	DNA helicase
VS_II0463	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
VS_II0464	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
VS_II0467	COG0583	DNA-binding transcription factor activity
VS_II0471	COG4964	Belongs to the GSP D family
VS_II0482	COG3706	GGDEF domain
VS_II0482	COG4251	negative regulation of phosphorylation
VS_II0482	COG5001	Diguanylate cyclase
VS_II0482	COG2203	Gaf domain
VS_II0483	COG2897	thiosulfate sulfurtransferase activity
VS_II0491	COG0302	gtp cyclohydrolase
VS_II0494	COG4681	YaeQ
VS_II0495	COG1278	Cold shock
VS_II0496	COG2133	pyrroloquinoline quinone binding
VS_II0498	COG1120	ATPase activity
VS_II0501	COG4774	siderophore transport
VS_II0503	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VS_II0504	COG1024	Enoyl-CoA hydratase
VS_II0507	COG1902	pentaerythritol trinitrate reductase activity
VS_II0507	COG0446	pyridine nucleotide-disulphide oxidoreductase
VS_II0510	COG1132	(ABC) transporter
VS_II0515	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VS_II0516	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VS_II0524	COG2824	Alkylphosphonate utilization operon protein PhnA
VS_II0531	COG0765	amino acid transport
VS_II0533	COG0765	amino acid transport
VS_II0534	COG1126	abc transporter atp-binding protein
VS_II0535	COG1979	alcohol dehydrogenase
VS_II0536	COG2207	Transcriptional regulator
VS_II0542	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VS_II0543	COG3059	membrane
VS_II0545	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
VS_II0547	COG2199	diguanylate cyclase activity
VS_II0550	COG1686	Belongs to the peptidase S11 family
VS_II0552	COG0583	DNA-binding transcription factor activity
VS_II0554	COG0564	pseudouridine synthase activity
VS_II0556	COG2130	NADP-dependent
VS_II0557	COG1309	transcriptional regulator
VS_II0558	COG0545	Peptidyl-prolyl cis-trans isomerase
VS_II0563	COG3604	Transcriptional regulator
VS_II0564	COG1017	nitric oxide dioxygenase activity
VS_II0564	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
VS_II0566	COG0038	chloride channel
VS_II0567	COG0523	cobalamin synthesis protein
VS_II0568	COG0513	Belongs to the DEAD box helicase family
VS_II0569	COG1280	lysine exporter protein (LysE YggA)
VS_II0585	COG0183	Belongs to the thiolase family
VS_II0589	COG5002	protein histidine kinase activity
VS_II0590	COG0745	RESPONSE REGULATOR receiver
VS_II0596	COG3005	denitrification pathway
VS_II0601	COG3850	Histidine kinase
VS_II0602	COG2197	response regulator
VS_II0603	COG3069	C4-dicarboxylate transmembrane transporter activity
VS_II0604	COG2188	Transcriptional regulator
VS_II0605	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VS_II0605	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
VS_II0605	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VS_II0606	COG0383	alpha-mannosidase activity
VS_II0607	COG1929	Belongs to the glycerate kinase type-1 family
VS_II0617	COG1012	belongs to the aldehyde dehydrogenase family
VS_II0620	COG4977	sequence-specific DNA binding
VS_II0620	COG1917	Cupin 2, conserved barrel domain protein
VS_II0625	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
VS_II0626	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
VS_II0629	COG4533	DNA binding
VS_II0638	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
VS_II0639	COG0494	nUDIX hydrolase
VS_II0640	COG0714	Associated with various cellular activities
VS_II0641	COG2425	protein containing a von Willebrand factor type A (vWA) domain
VS_II0656	COG1858	cytochrome C peroxidase
VS_II0657	COG1858	cytochrome C peroxidase
VS_II0666	COG3547	Transposase (IS116 IS110 IS902 family)
VS_II0668	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
VS_II0669	COG2146	nitrite reductase [NAD(P)H] activity
VS_II0670	COG2116	formate transmembrane transporter activity
VS_II0674	COG0745	RESPONSE REGULATOR receiver
VS_II0675	COG2205	protein histidine kinase activity
VS_II0676	COG1301	dicarboxylic acid transport
VS_II0677	COG4774	siderophore transport
VS_II0679	COG0811	peptide transport
VS_II0680	COG0811	peptide transport
VS_II0681	COG0848	biopolymer transport protein
VS_II0690	COG0803	Belongs to the bacterial solute-binding protein 9 family
VS_II0691	COG1121	(ABC) transporter
VS_II0692	COG1108	ABC-type Mn2 Zn2 transport systems permease components
VS_II0692	COG1321	iron dependent repressor
VS_II0697	COG0534	Mate efflux family protein
VS_II0704	COG3118	belongs to the thioredoxin family
VS_II0705	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
VS_II0711	COG1328	CTP reductase activity
VS_II0712	COG0602	queuosine metabolic process
VS_II0716	COG0189	ligase activity
VS_II0716	COG4067	protein conserved in archaea
VS_II0718	COG0488	(ABC) transporter
VS_II0723	COG0725	ABC transporter, periplasmic molybdate-binding protein
VS_II0724	COG4149	molybdate abc transporter
VS_II0725	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
VS_II0727	COG4251	negative regulation of phosphorylation
VS_II0727	COG3706	GGDEF domain
VS_II0727	COG5001	Diguanylate cyclase
VS_II0727	COG2203	Gaf domain
VS_II0729	COG3706	GGDEF domain
VS_II0732	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
VS_II0733	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
VS_II0739	COG3140	Belongs to the UPF0181 family
VS_II0741	COG3706	GGDEF domain
VS_II0743	COG0023	Translation Initiation Factor
VS_II0747	COG3266	domain, Protein
VS_II0748	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VS_II0748	COG1042	CoA-binding domain protein
VS_II0748	COG0045	succinate-CoA ligase (ADP-forming) activity
VS_II0749	COG0583	DNA-binding transcription factor activity
VS_II0751	COG1629	transport
VS_II0751	COG4771	TonB-dependent receptor
VS_II0754	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
VS_II0755	COG1984	allophanate hydrolase subunit 2
VS_II0757	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
VS_II0758	COG4181	ATPase activity
VS_II0760	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
VS_II0761	COG1716	ATPase activity
VS_II0761	COG5001	Diguanylate cyclase
VS_II0763	COG0768	penicillin binding
VS_II0764	COG0484	heat shock protein binding
VS_II0768	COG4533	DNA binding
VS_II0770	COG2050	protein possibly involved in aromatic compounds catabolism
VS_II0771	COG0501	Belongs to the peptidase M48B family
VS_II0773	COG2067	long-chain fatty acid transport protein
VS_II0774	COG2267	carboxylic ester hydrolase activity
VS_II0776	COG0513	Belongs to the DEAD box helicase family
VS_II0779	COG0861	Integral membrane protein TerC family
VS_II0782	COG0737	Belongs to the 5'-nucleotidase family
VS_II0783	COG0737	Belongs to the 5'-nucleotidase family
VS_II0784	COG3593	DNA synthesis involved in DNA repair
VS_II0786	COG0583	DNA-binding transcription factor activity
VS_II0787	COG2116	formate transmembrane transporter activity
VS_II0789	COG3038	cytochrome b561
VS_II0790	COG3038	cytochrome b561
VS_II0794	COG2200	EAL domain
VS_II0799	COG0513	Belongs to the DEAD box helicase family
VS_II0802	COG0814	amino acid
VS_II0803	COG0840	transmembrane signaling receptor activity
VS_II0804	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
VS_II0805	COG3437	response regulator, receiver
VS_II0805	COG0784	Response regulator, receiver
VS_II0808	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VS_II0810	COG3706	GGDEF domain
VS_II0811	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
VS_II0823	COG2801	Transposase and inactivated derivatives
VS_II0824	COG2801	Transposase and inactivated derivatives
VS_II0827	COG3547	Transposase (IS116 IS110 IS902 family)
VS_II0833	COG0534	Mate efflux family protein
VS_II0841	COG3048	D-serine ammonia-lyase activity
VS_II0843	COG1881	PFAM PEBP family protein
VS_II0844	COG5002	protein histidine kinase activity
VS_II0858	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VS_II0859	COG2205	protein histidine kinase activity
VS_II0859	COG0784	Response regulator, receiver
VS_II0860	COG1538	Outer membrane efflux protein
VS_II0861	COG1132	(ABC) transporter
VS_II0864	COG5002	protein histidine kinase activity
VS_II0864	COG0784	Response regulator, receiver
VS_II0864	COG2205	protein histidine kinase activity
VS_II0868	COG0641	radical SAM
VS_II0871	COG0583	DNA-binding transcription factor activity
VS_II0877	COG0714	Associated with various cellular activities
VS_II0879	COG3119	arylsulfatase activity
VS_II0880	COG3119	arylsulfatase activity
VS_II0882	COG0456	acetyltransferase
VS_II0883	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
VS_II0887	COG0384	phenazine biosynthesis protein PhzF
VS_II0888	COG1280	lysine exporter protein (LysE YggA)
VS_II0890	COG5001	Diguanylate cyclase
VS_II0890	COG3300	MHYT domain
VS_II0894	COG3278	Belongs to the heme-copper respiratory oxidase family
VS_II0902	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
VS_II0904	COG1012	belongs to the aldehyde dehydrogenase family
VS_II0906	COG0583	DNA-binding transcription factor activity
VS_II0908	COG0356	it plays a direct role in the translocation of protons across the membrane
VS_II0913	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
VS_II0915	COG0355	proton-transporting ATP synthase activity, rotational mechanism
VS_II0919	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VS_II0920	COG1538	Outer membrane efflux protein
VS_II0928	COG1228	amidohydrolase
VS_II0932	COG4172	Belongs to the ABC transporter superfamily
VS_II0933	COG4239	(ABC) transporter, permease
VS_II0934	COG4174	ABC transporter (Permease)
VS_II0935	COG4166	transmembrane transport
VS_II0940	COG1869	D-ribose catabolic process
VS_II0941	COG1129	ABC transporter
VS_II0942	COG1172	Belongs to the binding-protein-dependent transport system permease family
VS_II0943	COG1879	ABC-type sugar transport system periplasmic component
VS_II0944	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VS_II0945	COG1609	Transcriptional regulator
VS_II0948	COG0330	HflC and HflK could
VS_II0953	COG0243	molybdopterin cofactor binding
VS_II0992	COG1522	sequence-specific DNA binding
VS_II0999	COG2815	serine threonine protein kinase
VS_II0999	COG0515	serine threonine protein kinase
VS_II1004	COG3501	Rhs element vgr protein
VS_II1010	COG2885	chlorophyll binding
VS_II1024	COG0739	heme binding
VS_II1026	COG0243	molybdopterin cofactor binding
VS_II1027	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
VS_II1029	COG2223	nitrite transmembrane transporter activity
VS_II1030	COG0515	serine threonine protein kinase
VS_II1030	COG2815	serine threonine protein kinase
VS_II1031	COG1609	Transcriptional regulator
VS_II1032	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
VS_II1032	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
VS_II1033	COG1105	Belongs to the carbohydrate kinase PfkB family
VS_II1034	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VS_II1034	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
VS_II1034	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VS_II1037	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VS_II1042	COG0745	RESPONSE REGULATOR receiver
VS_II1046	COG0625	glutathione transferase activity
VS_II1048	COG1403	HNH endonuclease
VS_II1054	COG1879	ABC-type sugar transport system periplasmic component
VS_II1056	COG0840	transmembrane signaling receptor activity
VS_II1057	COG1522	sequence-specific DNA binding
VS_II1062	COG3291	Pkd domain containing protein
VS_II1062	COG4412	M6 family metalloprotease domain protein
VS_II1063	COG2814	Major facilitator Superfamily
VS_II1064	COG0583	DNA-binding transcription factor activity
VS_II1065	COG2205	protein histidine kinase activity
VS_II1065	COG0784	Response regulator, receiver
VS_II1066	COG3437	response regulator, receiver
VS_II1067	COG4604	ABC transporter, ATP-binding protein
VS_II1068	COG4605	iron ion homeostasis
VS_II1070	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VS_II1071	COG4607	ABC-type enterochelin transport system periplasmic component
VS_II1074	COG0628	permease
VS_II1076	COG1566	PFAM secretion protein HlyD family protein
VS_II1081	COG0583	DNA-binding transcription factor activity
VS_II1084	COG0840	transmembrane signaling receptor activity
VS_II1086	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
VS_II1087	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
VS_II1088	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
VS_II1089	COG1116	anion transmembrane transporter activity
VS_II1090	COG0351	phosphomethylpyrimidine kinase
VS_II1092	COG0697	spore germination
VS_II1097	COG0625	glutathione transferase activity
VS_II1102	COG3646	Phage regulatory protein
VS_II1112	COG4566	intracellular signal transduction
VS_II1114	COG0534	Mate efflux family protein
VS_II1115	COG0583	DNA-binding transcription factor activity
VS_II1123	COG1120	ATPase activity
VS_II1124	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VS_II1125	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VS_II1126	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
VS_II1127	COG4772	TonB-dependent receptor
VS_II1132	COG4264	IucA IucC family
VS_II1133	COG0019	diaminopimelate decarboxylase activity
VS_II1135	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
VS_II1137	COG0513	Belongs to the DEAD box helicase family
VS_II1141	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
VS_II1151	COG0667	Aldo Keto reductase
VS_II1152	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
VS_II1153	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
VS_II1154	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
VS_II1157	COG0778	Nitroreductase
VS_II1158	COG0513	Belongs to the DEAD box helicase family
VS_II1160	COG2176	DNA-directed DNA polymerase activity
VS_II1163	COG0513	Belongs to the DEAD box helicase family
VS_II1164	COG4989	oxidoreductase activity
VS_II1172	COG0668	transmembrane transport
VS_II1175	COG4232	protein-disulfide reductase activity
VS_II1177	COG3118	belongs to the thioredoxin family
VS_II1179	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
VS_II1180	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VS_II1181	COG2205	protein histidine kinase activity
VS_II1182	COG0745	RESPONSE REGULATOR receiver
VS_II1184	COG5001	Diguanylate cyclase
VS_II1186	COG2200	EAL domain
VS_II1186	COG2202	Pas domain
VS_II1186	COG2199	diguanylate cyclase activity
VS_II1187	COG2186	Transcriptional regulator
VS_II1188	COG1131	(ABC) transporter
VS_II1194	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
VS_II1194	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
VS_II1196	COG0564	pseudouridine synthase activity
VS_II1199	COG2814	Major facilitator Superfamily
VS_II1201	COG3708	Transcriptional regulator
VS_II1201	COG2207	Transcriptional regulator
VS_II1205	COG4533	DNA binding
VS_II1208	COG0189	ligase activity
VS_II1208	COG4067	protein conserved in archaea
VS_II1213	COG1175	transmembrane transport
VS_II1214	COG0395	ABC-type sugar transport system, permease component
VS_II1215	COG3842	ATPase activity
VS_II1216	COG0584	glycerophosphoryl diester phosphodiesterase
VS_II1221	COG0673	inositol 2-dehydrogenase activity
VS_II1223	COG2999	glutathione oxidoreductase activity
VS_II1226	COG0534	Mate efflux family protein
VS_II1227	COG2964	Protein conserved in bacteria
VS_II1230	COG0446	pyridine nucleotide-disulphide oxidoreductase
VS_II1250	COG1215	transferase activity, transferring glycosyl groups
VS_II1255	COG1595	DNA-templated transcription, initiation
VS_II1256	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
VS_II1260	COG0840	transmembrane signaling receptor activity
VS_II1264	COG4166	transmembrane transport
VS_II1266	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VS_II1268	COG4172	Belongs to the ABC transporter superfamily
VS_II1271	COG0583	DNA-binding transcription factor activity
VS_II1272	COG2910	NAD(P)H-binding
VS_II1274	COG1028	Short-chain dehydrogenase reductase Sdr
VS_II1275	COG1733	regulation of RNA biosynthetic process
VS_II1276	COG0583	DNA-binding transcription factor activity
VS_II1277	COG4221	oxidoreductase activity
VS_II1278	COG3047	cAMP biosynthetic process
VS_II1279	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
VS_II1283	COG3639	organic phosphonate transmembrane transporter activity
VS_II1284	COG3639	organic phosphonate transmembrane transporter activity
VS_II1285	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
VS_II1294	COG4948	Mandelate Racemase Muconate Lactonizing
VS_II1296	COG0583	DNA-binding transcription factor activity
VS_II1298	COG0366	Alpha amylase catalytic
VS_II1301	COG0583	DNA-binding transcription factor activity
VS_II1303	COG0840	transmembrane signaling receptor activity
VS_II1306	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
VS_II1309	COG0814	amino acid
VS_II1310	COG1846	Transcriptional regulator
VS_II1311	COG1764	response to oxidative stress
VS_II1312	COG0840	transmembrane signaling receptor activity
VS_II1315	COG1309	transcriptional regulator
VS_II1316	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VS_II1317	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VS_II1319	COG2207	Transcriptional regulator
VS_II1320	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VS_II1320	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
VS_II1320	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VS_II1323	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VS_II1324	COG4166	transmembrane transport
VS_II1327	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
VS_II1328	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
VS_II1332	COG1280	lysine exporter protein (LysE YggA)
VS_II1334	COG1012	belongs to the aldehyde dehydrogenase family
VS_II1336	COG3284	Transcriptional regulator
VS_II1337	COG0840	transmembrane signaling receptor activity
VS_II1338	COG0583	DNA-binding transcription factor activity
VS_II1339	COG0625	glutathione transferase activity
VS_II1340	COG3655	Transcriptional regulator
VS_II1349	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
VS_II1350	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
VS_II1351	COG1418	mRNA catabolic process
VS_II1359	COG1846	Transcriptional regulator
VS_II1360	COG0697	spore germination
VS_II1375	COG1067	ATP-dependent peptidase activity
VS_II1377	COG4172	Belongs to the ABC transporter superfamily
VS_II1383	COG1609	Transcriptional regulator
VS_II1386	COG3459	Glycosyltransferase 36 associated
VS_II1387	COG3842	ATPase activity
VS_II1388	COG2723	6-phospho-beta-galactosidase activity
VS_II1389	COG0395	ABC-type sugar transport system, permease component
VS_II1392	COG1609	Transcriptional regulator
VS_II1395	COG1505	serine-type exopeptidase activity
VS_II1396	COG0583	DNA-binding transcription factor activity
VS_II1397	COG1620	l-lactate permease
VS_II1398	COG1304	FMN binding
VS_II1402	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
VS_II1402	COG2207	Transcriptional regulator
VS_II1403	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
VS_II1411	COG1741	Belongs to the pirin family
VS_II1415	COG0596	Alpha beta hydrolase
VS_II1424	COG3788	relative of glutathione S-transferase, MAPEG superfamily
VS_II1426	COG0700	Nucleoside recognition
VS_II1427	COG3366	ferrous iron transmembrane transporter activity
VS_II1428	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
VS_II1430	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
VS_II1431	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
VS_II1440	COG0446	pyridine nucleotide-disulphide oxidoreductase
VS_II1442	COG0786	glutamate:sodium symporter activity
VS_II1446	COG1942	4-Oxalocrotonate Tautomerase
VS_II1448	COG1595	DNA-templated transcription, initiation
VS_II1449	COG3806	Anti-sigma factor
VS_II1451	COG0415	Belongs to the DNA photolyase family
VS_II1456	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
VS_II1462	COG4221	oxidoreductase activity
VS_II1463	COG0724	RNA recognition motif
VS_II1466	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
VS_II1470	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VS_II1470	COG1263	PTS System
VS_II1477	COG1028	Short-chain dehydrogenase reductase Sdr
VS_II1478	COG2814	Major facilitator Superfamily
VS_II1479	COG1902	pentaerythritol trinitrate reductase activity
VS_II1481	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VS_II1482	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VS_II1485	COG0612	Peptidase, M16
VS_II1486	COG0612	Peptidase, M16
VS_II1487	COG3279	Response regulator of the LytR AlgR family
VS_II1488	COG3275	phosphorelay sensor kinase activity
VS_II1491	COG4591	ABC-type transport system involved in lipoprotein release permease component
VS_II1494	COG0583	DNA-binding transcription factor activity
VS_II1498	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
VS_II1499	COG0583	DNA-binding transcription factor activity
VS_II1500	COG0840	transmembrane signaling receptor activity
VS_II1501	COG2084	Dehydrogenase
VS_II1509	COG3186	Phenylalanine-4-hydroxylase
VS_II1510	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
VS_II1518	COG0625	glutathione transferase activity
VS_II1520	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
VS_II1526	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
VS_II1526	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
VS_II1528	COG0444	Belongs to the ABC transporter superfamily
VS_II1529	COG4608	Belongs to the ABC transporter superfamily