locus-tag	class	description
H6S61_00060	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
H6S61_00070	COG1254	Belongs to the acylphosphatase family
H6S61_00075	COG2920	part of a sulfur-relay system
H6S61_00080	COG0670	Belongs to the BI1 family
H6S61_00085	COG1126	abc transporter atp-binding protein
H6S61_00090	COG0765	amino acid transport
H6S61_00095	COG4597	amino acid ABC transporter
H6S61_00100	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H6S61_00110	COG0437	4 iron, 4 sulfur cluster binding
H6S61_00115	COG0348	domain, Protein
H6S61_00120	COG0204	Acyl-transferase
H6S61_00180	COG1846	Transcriptional regulator
H6S61_00200	COG3971	2-oxopent-4-enoate hydratase activity
H6S61_00235	COG3384	dioxygenase
H6S61_00240	COG1012	belongs to the aldehyde dehydrogenase family
H6S61_00250	COG1960	acyl-CoA dehydrogenase activity
H6S61_00255	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
H6S61_00270	COG1115	amino acid carrier protein
H6S61_00300	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H6S61_00315	COG3290	protein histidine kinase activity
H6S61_00320	COG4565	transcriptional regulatory protein
H6S61_00325	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
H6S61_00330	COG0363	glucosamine-6-phosphate deaminase activity
H6S61_00335	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
H6S61_00375	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H6S61_00385	COG0438	transferase activity, transferring glycosyl groups
H6S61_00420	COG0438	transferase activity, transferring glycosyl groups
H6S61_00430	COG2204	response regulator
H6S61_00460	COG1366	Belongs to the anti-sigma-factor antagonist family
H6S61_00465	COG1793	dna ligase
H6S61_00470	COG3706	GGDEF domain
H6S61_00480	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H6S61_00495	COG2996	Protein conserved in bacteria
H6S61_00500	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
H6S61_00500	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
H6S61_00505	COG3008	intermembrane lipid transfer
H6S61_00510	COG2995	paraquat-inducible protein a
H6S61_00515	COG1132	(ABC) transporter
H6S61_00520	COG1956	GAF domain-containing protein
H6S61_00525	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
H6S61_00540	COG0308	aminopeptidase N
H6S61_00550	COG2902	Dehydrogenase
H6S61_00565	COG0116	Belongs to the methyltransferase superfamily
H6S61_00565	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
H6S61_00575	COG0488	(ABC) transporter
H6S61_00590	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H6S61_00595	COG1067	ATP-dependent peptidase activity
H6S61_00600	COG3120	sequence-specific DNA binding
H6S61_00620	COG4128	Pfam Zonular occludens toxin
H6S61_00665	COG0784	Response regulator, receiver
H6S61_00665	COG2205	protein histidine kinase activity
H6S61_00680	COG3278	Belongs to the heme-copper respiratory oxidase family
H6S61_00695	COG2010	Cytochrome c
H6S61_00705	COG2217	Heavy metal translocating P-type atpase
H6S61_00720	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H6S61_00725	COG0589	response to stress
H6S61_00740	COG2992	FlgJ-related protein
H6S61_00750	COG3842	ATPase activity
H6S61_00755	COG1176	ABC-type spermidine putrescine transport system, permease component I
H6S61_00760	COG1177	transmembrane transport
H6S61_00770	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
H6S61_00775	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
H6S61_00780	COG0004	ammonium transporteR
H6S61_00810	COG0437	4 iron, 4 sulfur cluster binding
H6S61_00815	COG3383	formate dehydrogenase (NAD+) activity
H6S61_00815	COG0243	molybdopterin cofactor binding
H6S61_00845	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
H6S61_00855	COG0488	(ABC) transporter
H6S61_00870	COG3852	Histidine kinase
H6S61_00875	COG2204	response regulator
H6S61_00885	COG4662	Binding-protein-dependent transport system inner membrane component
H6S61_00890	COG3842	ATPase activity
H6S61_00895	COG0746	molybdenum cofactor guanylyltransferase activity
H6S61_00910	COG1940	carbohydrate kinase activity
H6S61_00915	COG3148	PFAM DTW domain containing protein
H6S61_00925	COG0840	transmembrane signaling receptor activity
H6S61_00930	COG0791	NLP P60 protein
H6S61_00940	COG3706	GGDEF domain
H6S61_00960	COG0307	riboflavin synthase, alpha
H6S61_00965	COG0534	Mate efflux family protein
H6S61_01010	COG4115	mRNA cleavage
H6S61_01015	COG2161	toxin-antitoxin pair type II binding
H6S61_01060	COG1942	4-Oxalocrotonate Tautomerase
H6S61_01295	COG0454	-acetyltransferase
H6S61_01330	COG3093	addiction module antidote protein HigA
H6S61_01335	COG3549	Plasmid maintenance system killer
H6S61_01515	COG2944	sequence-specific DNA binding
H6S61_01520	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
H6S61_01810	COG1335	isochorismatase
H6S61_01870	COG4628	conserved protein (DUF2132)
H6S61_01965	COG0454	-acetyltransferase
H6S61_02050	COG4628	conserved protein (DUF2132)
H6S61_02245	COG0346	lactoylglutathione lyase activity
H6S61_02250	COG1028	Short-chain dehydrogenase reductase Sdr
H6S61_02260	COG4628	conserved protein (DUF2132)
H6S61_02310	COG1942	4-Oxalocrotonate Tautomerase
H6S61_02360	COG1683	Conserved Protein
H6S61_02560	COG0291	Belongs to the bacterial ribosomal protein bL35 family
H6S61_02580	COG4326	sporulation control protein
H6S61_02590	COG1228	amidohydrolase
H6S61_02600	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
H6S61_02605	COG2986	histidine ammonia-lyase
H6S61_02615	COG5640	endopeptidase activity
H6S61_02620	COG2020	methyltransferase activity
H6S61_02625	COG0277	FAD linked oxidase domain protein
H6S61_02625	COG0247	lactate metabolic process
H6S61_02640	COG2885	chlorophyll binding
H6S61_02655	COG0295	cytidine deaminase activity
H6S61_02660	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
H6S61_02665	COG0500	methyltransferase
H6S61_02675	COG0776	regulation of translation
H6S61_02695	COG0072	phenylalanine-tRNA ligase activity
H6S61_02695	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H6S61_02700	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
H6S61_02785	COG1166	arginine decarboxylase activity
H6S61_02790	COG0010	Belongs to the arginase family
H6S61_02795	COG2814	Major facilitator Superfamily
H6S61_02800	COG5380	lipid catabolic process
H6S61_02805	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
H6S61_02830	COG1643	Atp-dependent helicase
H6S61_02840	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
H6S61_02880	COG2894	cell division
H6S61_02890	COG4964	Belongs to the GSP D family
H6S61_02920	COG3713	MltA-interacting MipA family protein
H6S61_02940	COG3706	GGDEF domain
H6S61_02950	COG0443	Heat shock 70 kDa protein
H6S61_02955	COG0443	Heat shock 70 kDa protein
H6S61_02985	COG2165	general secretion pathway protein
H6S61_03000	COG0297	glycogen (starch) synthase activity
H6S61_03000	COG0438	transferase activity, transferring glycosyl groups
H6S61_03030	COG1596	polysaccharide export
H6S61_03045	COG1115	amino acid carrier protein
H6S61_03050	COG1132	(ABC) transporter
H6S61_03055	COG1132	(ABC) transporter
H6S61_03070	COG0783	Belongs to the Dps family
H6S61_03085	COG0814	amino acid
H6S61_03090	COG1597	lipid kinase activity
H6S61_03100	COG4667	esterase of the alpha-beta hydrolase superfamily
H6S61_03105	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
H6S61_03120	COG0583	DNA-binding transcription factor activity
H6S61_03125	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
H6S61_03130	COG1328	CTP reductase activity
H6S61_03135	COG5001	Diguanylate cyclase
H6S61_03135	COG3300	MHYT domain
H6S61_03150	COG2199	diguanylate cyclase activity
H6S61_03150	COG2200	EAL domain
H6S61_03155	COG3706	GGDEF domain
H6S61_03165	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H6S61_03165	COG4191	Histidine kinase
H6S61_03170	COG0471	metal ion transport
H6S61_03185	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H6S61_03190	COG3283	Transcriptional regulator of aromatic amino acids metabolism
H6S61_03195	COG3768	UPF0283 membrane protein
H6S61_03200	COG3106	COG3106 Predicted ATPase
H6S61_03220	COG2205	protein histidine kinase activity
H6S61_03220	COG0784	Response regulator, receiver
H6S61_03230	COG0494	nUDIX hydrolase
H6S61_03235	COG0814	amino acid
H6S61_03240	COG1760	l-serine dehydratase
H6S61_03255	COG0720	synthase
H6S61_03260	COG0840	transmembrane signaling receptor activity
H6S61_03265	COG0017	Asparaginyl-tRNA synthetase
H6S61_03275	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H6S61_03290	COG2770	Histidine kinase
H6S61_03290	COG3437	response regulator, receiver
H6S61_03295	COG1448	Aminotransferase
H6S61_03315	COG0840	transmembrane signaling receptor activity
H6S61_03320	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H6S61_03325	COG1846	Transcriptional regulator
H6S61_03350	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
H6S61_03365	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H6S61_03370	COG3108	Peptidase M15
H6S61_03375	COG2989	Protein conserved in bacteria
H6S61_03405	COG2186	Transcriptional regulator
H6S61_03410	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
H6S61_03420	COG0653	protein targeting
H6S61_03435	COG0366	Alpha amylase catalytic
H6S61_03445	COG4120	Belongs to the binding-protein-dependent transport system permease family
H6S61_03455	COG3092	negative regulation of chromosome organization
H6S61_03460	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
H6S61_03465	COG0857	belongs to the CobB CobQ family
H6S61_03465	COG0280	phosphate acetyltransferase
H6S61_03475	COG0583	DNA-binding transcription factor activity
H6S61_03500	COG1032	radical SAM domain protein
H6S61_03520	COG2207	Transcriptional regulator
H6S61_03555	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H6S61_03570	COG0861	Integral membrane protein TerC family
H6S61_03575	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H6S61_03580	COG1454	alcohol dehydrogenase
H6S61_03585	COG0235	Class ii aldolase
H6S61_03590	COG4154	Belongs to the RbsD FucU family
H6S61_03595	COG1070	Carbohydrate kinase
H6S61_03600	COG2407	Converts the aldose L-fucose into the corresponding ketose L-fuculose
H6S61_03605	COG0738	Major facilitator superfamily
H6S61_03610	COG1349	DNA-binding transcription factor activity
H6S61_03615	COG0840	transmembrane signaling receptor activity
H6S61_03620	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H6S61_03635	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
H6S61_03650	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
H6S61_03660	COG0732	type I restriction modification DNA specificity domain
H6S61_03665	COG4804	nuclease activity
H6S61_03670	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
H6S61_03715	COG2205	protein histidine kinase activity
H6S61_03715	COG0784	Response regulator, receiver
H6S61_03725	COG0754	glutathionylspermidine amidase activity
H6S61_03735	COG3766	membrane
H6S61_03745	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
H6S61_03750	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
H6S61_03755	COG2885	chlorophyll binding
H6S61_03760	COG0823	Involved in the tonB-independent uptake of proteins
H6S61_03775	COG0811	peptide transport
H6S61_03780	COG0824	Thioesterase
H6S61_03790	COG4890	Cyd operon protein YbgT
H6S61_03795	COG1294	oxidase, subunit
H6S61_03800	COG1271	oxidase subunit
H6S61_03805	COG2255	four-way junction helicase activity
H6S61_03810	COG0632	four-way junction helicase activity
H6S61_03830	COG4106	trans-aconitate 2-methyltransferase activity
H6S61_03835	COG0500	methyltransferase
H6S61_03840	COG4067	protein conserved in archaea
H6S61_03840	COG0189	ligase activity
H6S61_03870	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
H6S61_03875	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
H6S61_03880	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
H6S61_03885	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H6S61_03890	COG1434	Gram-negative-bacterium-type cell wall biogenesis
H6S61_03895	COG0745	RESPONSE REGULATOR receiver
H6S61_03905	COG1609	Transcriptional regulator
H6S61_03910	COG3070	regulator of competence-specific genes
H6S61_03935	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
H6S61_03940	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H6S61_03950	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
H6S61_03965	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
H6S61_03970	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
H6S61_03975	COG0542	response to heat
H6S61_03980	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
H6S61_03985	COG1278	Cold shock
H6S61_04005	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
H6S61_04010	COG1199	ATP-dependent helicase activity
H6S61_04015	COG0730	response to heat
H6S61_04020	COG3923	Primosomal replication protein n
H6S61_04035	COG0708	Exodeoxyribonuclease III
H6S61_04075	COG1882	Formate acetyltransferase
H6S61_04090	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
H6S61_04100	COG3013	Belongs to the UPF0304 family
H6S61_04105	COG2766	serine protein kinase
H6S61_04110	COG2718	Belongs to the UPF0229 family
H6S61_04115	COG2719	SpoVR family
H6S61_04120	COG2199	diguanylate cyclase activity
H6S61_04125	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
H6S61_04130	COG2835	tetraacyldisaccharide 4'-kinase activity
H6S61_04135	COG1663	tetraacyldisaccharide 4'-kinase activity
H6S61_04145	COG0658	competence protein
H6S61_04145	COG2333	competence protein COMEC
H6S61_04155	COG4591	ABC-type transport system involved in lipoprotein release permease component
H6S61_04160	COG1136	(ABC) transporter
H6S61_04165	COG4591	ABC-type transport system involved in lipoprotein release permease component
H6S61_04175	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
H6S61_04190	COG1252	NADH dehydrogenase
H6S61_04220	COG0537	adenosine 5'-monophosphoramidase activity
H6S61_04245	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
H6S61_04245	COG0617	tRNA 3'-terminal CCA addition
H6S61_04245	COG0517	IMP dehydrogenase activity
H6S61_04250	COG3706	GGDEF domain
H6S61_04255	COG1982	Orn Lys Arg decarboxylase major
H6S61_04260	COG0531	amino acid
H6S61_04265	COG3710	Transcriptional regulator
H6S61_04280	COG2203	Gaf domain
H6S61_04280	COG2199	diguanylate cyclase activity
H6S61_04285	COG2239	Acts as a magnesium transporter
H6S61_04295	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
H6S61_04300	COG2226	methyltransferase
H6S61_04315	COG1785	Belongs to the alkaline phosphatase family
H6S61_04325	COG0346	lactoylglutathione lyase activity
H6S61_04335	COG2983	Belongs to the UPF0260 family
H6S61_04350	COG0745	RESPONSE REGULATOR receiver
H6S61_04355	COG2205	protein histidine kinase activity
H6S61_04370	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
H6S61_04375	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
H6S61_04385	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
H6S61_04390	COG2832	Protein of unknown function (DUF454)
H6S61_04395	COG0745	RESPONSE REGULATOR receiver
H6S61_04400	COG0583	DNA-binding transcription factor activity
H6S61_04405	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
H6S61_04410	COG1286	toxin biosynthetic process
H6S61_04415	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
H6S61_04420	COG0285	dihydrofolate synthase activity
H6S61_04425	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
H6S61_04430	COG0101	tRNA pseudouridine synthase activity
H6S61_04440	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
H6S61_04450	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H6S61_04465	COG3101	peptidyl-lysine hydroxylation
H6S61_04470	COG2860	membrane
H6S61_04480	COG2890	protein-(glutamine-N5) methyltransferase activity
H6S61_04485	COG2840	Smr protein MutS2
H6S61_04490	COG2062	phosphohistidine phosphatase, SixA
H6S61_04495	COG1025	Belongs to the peptidase M16 family
H6S61_04520	COG2067	long-chain fatty acid transport protein
H6S61_04525	COG2067	long-chain fatty acid transport protein
H6S61_04530	COG2853	Lipoprotein
H6S61_04540	COG3088	subunit of a heme lyase
H6S61_04540	COG4235	cytochrome complex assembly
H6S61_04545	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H6S61_04550	COG1138	Cytochrome C-type biogenesis protein
H6S61_04555	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
H6S61_04560	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H6S61_04565	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H6S61_04570	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H6S61_04575	COG4133	protoheme IX ABC transporter activity
H6S61_04585	COG0835	chemotaxis
H6S61_04595	COG1192	Involved in chromosome partitioning
H6S61_04605	COG2198	Histidine kinase
H6S61_04605	COG0643	Histidine kinase
H6S61_04605	COG0784	Response regulator, receiver
H6S61_04610	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
H6S61_04645	COG1684	flagellar biosynthetic protein fliR
H6S61_04650	COG1987	bacterial-type flagellum assembly
H6S61_04700	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
H6S61_04710	COG1677	Flagellar hook-basal body complex protein FliE
H6S61_04730	COG1516	flagellar protein fliS
H6S61_04740	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
H6S61_04745	COG1334	flagellar protein FlaG
H6S61_04750	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H6S61_04755	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H6S61_04760	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H6S61_04765	COG2837	iron assimilation
H6S61_04790	COG1393	Belongs to the ArsC family
H6S61_04800	COG1876	peptidase activity
H6S61_04810	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
H6S61_04815	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H6S61_04820	COG2716	regulation of RNA biosynthetic process
H6S61_04825	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
H6S61_04840	COG4783	chaperone-mediated protein folding
H6S61_04845	COG1393	Belongs to the ArsC family
H6S61_04865	COG2233	PERMEase
H6S61_04870	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
H6S61_04875	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
H6S61_04880	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
H6S61_04885	COG0121	glutamine amidotransferase
H6S61_04895	COG1960	acyl-CoA dehydrogenase activity
H6S61_04925	COG0328	RNA-DNA hybrid ribonuclease activity
H6S61_04930	COG2226	methyltransferase
H6S61_04935	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H6S61_04940	COG1388	LysM domain
H6S61_04940	COG0741	lytic transglycosylase activity
H6S61_04955	COG0347	Belongs to the P(II) protein family
H6S61_04970	COG0825	malonyl-CoA metabolic process
H6S61_04975	COG0587	DNA-directed DNA polymerase activity
H6S61_04980	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
H6S61_04985	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H6S61_04990	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H6S61_04995	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H6S61_05005	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
H6S61_05010	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H6S61_05015	COG0750	zinc metalloprotease
H6S61_05025	COG0575	Belongs to the CDS family
H6S61_05030	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
H6S61_05035	COG0233	cytoplasmic translational termination
H6S61_05040	COG0528	UMP kinase activity
H6S61_05045	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
H6S61_05050	COG0052	Belongs to the universal ribosomal protein uS2 family
H6S61_05055	COG0024	Methionine aminopeptidase
H6S61_05060	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
H6S61_05100	COG1671	Belongs to the UPF0178 family
H6S61_05105	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
H6S61_05115	COG0254	rRNA binding
H6S61_05120	COG1720	tRNA m6t6A37 methyltransferase activity
H6S61_05145	COG0733	neurotransmitter:sodium symporter activity
H6S61_05160	COG0514	ATP-dependent DNA helicase (RecQ)
H6S61_05165	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H6S61_05180	COG1477	protein flavinylation
H6S61_05185	COG2871	sodium ion transport
H6S61_05190	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
H6S61_05200	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
H6S61_05205	COG1805	sodium ion transport
H6S61_05210	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
H6S61_05215	COG0271	Belongs to the BolA IbaG family
H6S61_05220	COG2813	Specifically methylates the guanine in position
H6S61_05235	COG2211	Major facilitator Superfamily
H6S61_05245	COG1595	DNA-templated transcription, initiation
H6S61_05255	COG3248	Nucleoside-binding outer membrane protein
H6S61_05260	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
H6S61_05265	COG0693	protein deglycase activity
H6S61_05270	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
H6S61_05280	COG2166	iron-sulfur cluster assembly
H6S61_05285	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
H6S61_05290	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
H6S61_05310	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H6S61_05315	COG1074	ATP-dependent DNA helicase activity
H6S61_05320	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
H6S61_05325	COG3083	sulfuric ester hydrolase activity
H6S61_05340	COG3141	response to X-ray
H6S61_05345	COG2171	N-acyltransferase activity
H6S61_05350	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
H6S61_05355	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
H6S61_05360	COG1349	DNA-binding transcription factor activity
H6S61_05365	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
H6S61_05380	COG0189	ligase activity
H6S61_05380	COG0569	domain protein
H6S61_05395	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H6S61_05405	COG0840	transmembrane signaling receptor activity
H6S61_05410	COG2017	converts alpha-aldose to the beta-anomer
H6S61_05420	COG1085	galactose-1-phosphate uridylyltransferase
H6S61_05425	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H6S61_05430	COG1609	Transcriptional regulator
H6S61_05440	COG3250	beta-galactosidase activity
H6S61_05445	COG2731	YhcH YjgK YiaL family protein
H6S61_05450	COG0531	amino acid
H6S61_05455	COG0531	amino acid
H6S61_05470	COG0583	DNA-binding transcription factor activity
H6S61_05475	COG2059	Chromate
H6S61_05525	COG4964	Belongs to the GSP D family
H6S61_05560	COG1022	Amp-dependent synthetase and ligase
H6S61_05565	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
H6S61_05585	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
H6S61_05595	COG0560	Phosphoserine phosphatase
H6S61_05605	COG0813	purine-nucleoside phosphorylase activity
H6S61_05610	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
H6S61_05615	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
H6S61_05620	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
H6S61_05625	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
H6S61_05630	COG0084	hydrolase, TatD family'
H6S61_05645	COG3706	GGDEF domain
H6S61_05655	COG0456	acetyltransferase
H6S61_05665	COG3153	acetyltransferase
H6S61_05670	COG3154	lipid carrier protein
H6S61_05680	COG0826	peptidase U32
H6S61_05685	COG0826	peptidase U32
H6S61_05690	COG0534	Mate efflux family protein
H6S61_05705	COG1185	polyribonucleotide nucleotidyltransferase activity
H6S61_05735	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
H6S61_05740	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
H6S61_05745	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
H6S61_05755	COG0195	Participates in both transcription termination and antitermination
H6S61_05760	COG0779	Required for maturation of 30S ribosomal subunits
H6S61_05775	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
H6S61_05780	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H6S61_05785	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
H6S61_05790	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H6S61_05795	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
H6S61_05800	COG1534	Rna-binding protein
H6S61_05815	COG2027	D-alanyl-D-alanine carboxypeptidase
H6S61_05820	COG2832	Protein of unknown function (DUF454)
H6S61_05825	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
H6S61_05830	COG0739	heme binding
H6S61_05855	COG0628	permease
H6S61_05865	COG2205	protein histidine kinase activity
H6S61_05865	COG0784	Response regulator, receiver
H6S61_05875	COG0601	transmembrane transport
H6S61_05880	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H6S61_05885	COG0444	Belongs to the ABC transporter superfamily
H6S61_05890	COG4608	Belongs to the ABC transporter superfamily
H6S61_05900	COG2971	BadF BadG BcrA BcrD
H6S61_05915	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H6S61_05920	COG3842	ATPase activity
H6S61_05930	COG1840	ABC-type Fe3 transport system, periplasmic component
H6S61_05935	COG0004	ammonium transporteR
H6S61_05940	COG0347	Belongs to the P(II) protein family
H6S61_05945	COG3112	Uncharacterised protein family (UPF0231)
H6S61_05950	COG3835	regulator
H6S61_05955	COG2610	gluconate transmembrane transporter activity
H6S61_05960	COG1929	Belongs to the glycerate kinase type-1 family
H6S61_05965	COG1049	propionate catabolic process, 2-methylcitrate cycle
H6S61_05970	COG1752	Esterase of the alpha-beta hydrolase superfamily
H6S61_05975	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H6S61_05980	COG1643	Atp-dependent helicase
H6S61_05985	COG1489	DNA binding
H6S61_05990	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
H6S61_05995	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H6S61_06005	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
H6S61_06010	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
H6S61_06020	COG0842	Transport permease protein
H6S61_06025	COG1131	(ABC) transporter
H6S61_06030	COG0659	secondary active sulfate transmembrane transporter activity
H6S61_06035	COG0288	reversible hydration of carbon dioxide
H6S61_06050	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H6S61_06055	COG0508	dehydrogenase complex catalyzes the overall conversion of
H6S61_06060	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
H6S61_06065	COG2186	Transcriptional regulator
H6S61_06070	COG3023	N-Acetylmuramoyl-L-alanine amidase
H6S61_06080	COG4969	Belongs to the N-Me-Phe pilin family
H6S61_06085	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H6S61_06090	COG1459	type II secretion system
H6S61_06100	COG0237	dephospho-CoA kinase activity
H6S61_06110	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
H6S61_06115	COG0335	large ribosomal subunit rRNA binding
H6S61_06120	COG0336	Belongs to the RNA methyltransferase TrmD family
H6S61_06125	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
H6S61_06130	COG0228	four-way junction DNA binding
H6S61_06135	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
H6S61_06140	COG4137	Cytochrome C assembly protein
H6S61_06145	COG4536	flavin adenine dinucleotide binding
H6S61_06150	COG1854	S-ribosylhomocysteine lyase activity
H6S61_06165	COG0612	Peptidase, M16
H6S61_06170	COG1238	metal cluster binding
H6S61_06180	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
H6S61_06190	COG3630	sodium ion export across plasma membrane
H6S61_06235	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
H6S61_06240	COG0527	aspartate kinase activity
H6S61_06245	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
H6S61_06255	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
H6S61_06265	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
H6S61_06270	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H6S61_06275	COG1388	LysM domain
H6S61_06275	COG4942	peptidase
H6S61_06280	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
H6S61_06290	COG0585	pseudouridine synthase activity
H6S61_06295	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
H6S61_06305	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
H6S61_06315	COG0504	CTP synthase activity
H6S61_06320	COG3956	TIGRFAM MazG family protein
H6S61_06325	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H6S61_06330	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H6S61_06355	COG0736	holo-[acyl-carrier-protein] synthase activity
H6S61_06360	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
H6S61_06365	COG1381	Involved in DNA repair and RecF pathway recombination
H6S61_06370	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
H6S61_06385	COG0481	GTPase activity
H6S61_06390	COG3086	response to oxidative stress
H6S61_06405	COG1595	DNA-templated transcription, initiation
H6S61_06410	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
H6S61_06425	COG0354	folic acid binding
H6S61_06440	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H6S61_06445	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H6S61_06450	COG3079	Belongs to the UPF0149 family
H6S61_06455	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
H6S61_06465	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
H6S61_06475	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H6S61_06490	COG1279	arginine transmembrane transporter activity
H6S61_06495	COG0668	transmembrane transport
H6S61_06500	COG0191	fructose-bisphosphate aldolase activity
H6S61_06505	COG0126	phosphoglycerate kinase activity
H6S61_06510	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H6S61_06520	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
H6S61_06525	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
H6S61_06540	COG2356	endonuclease I
H6S61_06550	COG1385	rRNA (uridine-N3-)-methyltransferase activity
H6S61_06560	COG1678	Uncharacterized ACR, COG1678
H6S61_06565	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
H6S61_06580	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
H6S61_06585	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
H6S61_06590	COG0762	integral membrane protein
H6S61_06605	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
H6S61_06610	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H6S61_06615	COG2066	Belongs to the glutaminase family
H6S61_06620	COG0220	tRNA (guanine-N7-)-methyltransferase activity
H6S61_06630	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
H6S61_06635	COG0741	lytic transglycosylase activity
H6S61_06750	COG1609	Transcriptional regulator
H6S61_06755	COG3394	polysaccharide catabolic process
H6S61_06760	COG1486	melibiose metabolic process
H6S61_06765	COG1447	Phosphotransferase system cellobiose-specific component IIA
H6S61_06775	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H6S61_06780	COG0726	polysaccharide deacetylase
H6S61_06840	COG2378	regulation of single-species biofilm formation
H6S61_06860	COG4974	Belongs to the 'phage' integrase family
H6S61_06885	COG0795	lipopolysaccharide-transporting ATPase activity
H6S61_06890	COG0795	lipopolysaccharide-transporting ATPase activity
H6S61_06895	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
H6S61_06900	COG2927	DNA polymerase III (CHI subunit)
H6S61_06905	COG0525	valine-tRNA ligase activity
H6S61_06915	COG4269	membrane
H6S61_06925	COG0456	acetyltransferase
H6S61_06960	COG0251	oxidation-reduction process
H6S61_06965	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H6S61_06975	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
H6S61_06980	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
H6S61_06985	COG0312	modulator of DNA gyrase
H6S61_06990	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H6S61_06995	COG3164	Protein of unknown function
H6S61_07005	COG0424	maF-like protein
H6S61_07010	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
H6S61_07015	COG1792	Involved in formation and maintenance of cell shape
H6S61_07020	COG1077	Cell shape determining protein MreB Mrl
H6S61_07050	COG2165	general secretion pathway protein
H6S61_07055	COG2165	general secretion pathway protein
H6S61_07065	COG1459	type II secretion system
H6S61_07070	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H6S61_07080	COG3409	Peptidoglycan-binding domain 1 protein
H6S61_07080	COG3267	Type II secretory pathway component ExeA
H6S61_07105	COG2199	diguanylate cyclase activity
H6S61_07105	COG2200	EAL domain
H6S61_07125	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
H6S61_07135	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
H6S61_07140	COG0527	aspartate kinase activity
H6S61_07145	COG1410	methionine synthase
H6S61_07145	COG0646	methionine synthase
H6S61_07240	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H6S61_07270	COG0735	belongs to the Fur family
H6S61_07285	COG0432	Pfam Uncharacterised protein family UPF0047
H6S61_07295	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H6S61_07310	COG0359	binds to the 23S rRNA
H6S61_07320	COG2965	DNA replication, synthesis of RNA primer
H6S61_07325	COG0360	Binds together with S18 to 16S ribosomal RNA
H6S61_07330	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
H6S61_07335	COG0338	D12 class N6 adenine-specific DNA methyltransferase
H6S61_07345	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
H6S61_07350	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
H6S61_07380	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
H6S61_07395	COG0165	Argininosuccinate lyase
H6S61_07395	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
H6S61_07400	COG0137	argininosuccinate synthase activity
H6S61_07410	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
H6S61_07415	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H6S61_07420	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
H6S61_07430	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
H6S61_07435	COG0527	aspartate kinase activity
H6S61_07435	COG0460	homoserine dehydrogenase
H6S61_07440	COG0626	cystathionine gamma-synthase activity
H6S61_07445	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
H6S61_07450	COG0281	malic enzyme
H6S61_07455	COG0254	rRNA binding
H6S61_07460	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
H6S61_07465	COG1609	Transcriptional regulator
H6S61_07475	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
H6S61_07480	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
H6S61_07485	COG1575	Belongs to the MenA family. Type 1 subfamily
H6S61_07495	COG3074	FtsZ-dependent cytokinesis
H6S61_07500	COG1494	fructose-1,6-bisphosphatase
H6S61_07525	COG0149	triose-phosphate isomerase activity
H6S61_07530	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H6S61_07540	COG2906	2 iron, 2 sulfur cluster binding
H6S61_07550	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
H6S61_07555	COG0049	tRNA binding
H6S61_07560	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
H6S61_07575	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
H6S61_07580	COG2964	Protein conserved in bacteria
H6S61_07585	COG0545	Peptidyl-prolyl cis-trans isomerase
H6S61_07595	COG2900	Belongs to the SlyX family
H6S61_07605	COG1047	Peptidyl-prolyl cis-trans
H6S61_07620	COG2249	NAD(P)H dehydrogenase (quinone) activity
H6S61_07625	COG0488	(ABC) transporter
H6S61_07640	COG3089	Belongs to the UPF0270 family
H6S61_07645	COG3954	Phosphoribulokinase
H6S61_07650	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H6S61_07660	COG1012	belongs to the aldehyde dehydrogenase family
H6S61_07670	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H6S61_07690	COG0180	Tryptophanyl-tRNA synthetase
H6S61_07695	COG0546	phosphoglycolate phosphatase activity
H6S61_07700	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H6S61_07705	COG0557	exoribonuclease II activity
H6S61_07710	COG0402	S-adenosylhomocysteine deaminase activity
H6S61_07715	COG1959	2 iron, 2 sulfur cluster binding
H6S61_07725	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
H6S61_07735	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
H6S61_07740	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
H6S61_07745	COG0330	HflC and HflK could
H6S61_07750	COG0330	HflC and HflK could
H6S61_07755	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
H6S61_07760	COG1923	regulation of RNA biosynthetic process
H6S61_07770	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
H6S61_07775	COG0860	N-Acetylmuramoyl-L-alanine amidase
H6S61_07780	COG0802	atpase or kinase
H6S61_07785	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
H6S61_07845	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
H6S61_07850	COG1162	GTPase activity
H6S61_07855	COG0688	phosphatidylethanolamine metabolic process
H6S61_07860	COG0471	metal ion transport
H6S61_07870	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
H6S61_07875	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H6S61_07880	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
H6S61_07885	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
H6S61_07890	COG1045	serine acetyltransferase
H6S61_07895	COG4942	peptidase
H6S61_07915	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
H6S61_07920	COG1053	succinate dehydrogenase
H6S61_07925	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
H6S61_07930	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
H6S61_07935	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
H6S61_07945	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
H6S61_07950	COG1509	lysine 2,3-aminomutase activity
H6S61_07955	COG1285	pathogenesis
H6S61_07965	COG0459	protein refolding
H6S61_07970	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
H6S61_07975	COG0534	Mate efflux family protein
H6S61_07980	COG0205	6-phosphofructokinase activity
H6S61_07990	COG3678	ATP-independent chaperone mediated protein folding
H6S61_07995	COG0745	RESPONSE REGULATOR receiver
H6S61_08000	COG2205	protein histidine kinase activity
H6S61_08005	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
H6S61_08010	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
H6S61_08020	COG1027	Aspartate ammonia-lyase
H6S61_08025	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
H6S61_08030	COG4232	protein-disulfide reductase activity
H6S61_08040	COG2095	MarC family integral membrane protein
H6S61_08050	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H6S61_08065	COG2205	protein histidine kinase activity
H6S61_08065	COG2198	Histidine kinase
H6S61_08065	COG0784	Response regulator, receiver
H6S61_08070	COG2814	Major facilitator Superfamily
H6S61_08085	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H6S61_08090	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
H6S61_08095	COG0511	ligase activity, forming carbon-carbon bonds
H6S61_08100	COG0439	Biotin carboxylase
H6S61_08105	COG2264	protein methyltransferase activity
H6S61_08115	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
H6S61_08120	COG0840	transmembrane signaling receptor activity
H6S61_08125	COG0789	Transcriptional regulator
H6S61_08130	COG0138	bifunctional purine biosynthesis protein purh
H6S61_08150	COG1253	flavin adenine dinucleotide binding
H6S61_08155	COG3068	Protein conserved in bacteria
H6S61_08160	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H6S61_08165	COG1573	uracil-dna glycosylase
H6S61_08175	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
H6S61_08195	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
H6S61_08200	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
H6S61_08205	COG0085	RNA polymerase activity
H6S61_08210	COG0222	ribosome binding
H6S61_08215	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
H6S61_08220	COG0081	regulation of translation
H6S61_08235	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
H6S61_08240	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
H6S61_08275	COG0812	UDP-N-acetylmuramate dehydrogenase activity
H6S61_08285	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H6S61_08370	COG3118	belongs to the thioredoxin family
H6S61_08380	COG0248	Ppx GppA phosphatase
H6S61_08385	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
H6S61_08395	COG0514	ATP-dependent DNA helicase (RecQ)
H6S61_08400	COG2962	Rard protein
H6S61_08410	COG1280	lysine exporter protein (LysE YggA)
H6S61_08415	COG0210	DNA helicase
H6S61_08455	COG0006	proline dipeptidase activity
H6S61_08455	COG0006	proline dipeptidase activity
H6S61_08465	COG2022	thiamine diphosphate biosynthetic process
H6S61_08475	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
H6S61_08485	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
H6S61_08490	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
H6S61_08495	COG2132	Multicopper oxidase
H6S61_08540	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
H6S61_08550	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
H6S61_08555	COG0408	coproporphyrinogen oxidase activity
H6S61_08560	COG0009	L-threonylcarbamoyladenylate synthase
H6S61_08565	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
H6S61_08575	COG0551	DNA topoisomerase type I activity
H6S61_08580	COG2922	Belongs to the Smg family
H6S61_08585	COG0758	DNA mediated transformation
H6S61_08595	COG0242	peptide deformylase activity
H6S61_08600	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
H6S61_08605	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H6S61_08605	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
H6S61_08610	COG0569	domain protein
H6S61_08615	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H6S61_08620	COG1272	protein, Hemolysin III
H6S61_08625	COG4326	sporulation control protein
H6S61_08635	COG3084	Protein conserved in bacteria
H6S61_08645	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
H6S61_08650	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H6S61_08655	COG0204	Acyl-transferase
H6S61_08665	COG0606	chelatase, subunit chli
H6S61_08675	COG3978	acetolactate synthase activity
H6S61_08680	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H6S61_08685	COG0129	dihydroxy-acid dehydratase activity
H6S61_08695	COG0583	DNA-binding transcription factor activity
H6S61_08700	COG2814	Major facilitator Superfamily
H6S61_08710	COG0765	amino acid transport
H6S61_08720	COG0355	proton-transporting ATP synthase activity, rotational mechanism
H6S61_08725	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
H6S61_08730	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
H6S61_08735	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
H6S61_08740	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
H6S61_08745	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
H6S61_08755	COG0356	it plays a direct role in the translocation of protons across the membrane
H6S61_08760	COG3312	ion transport
H6S61_08765	COG1475	DNA binding
H6S61_08770	COG1192	Involved in chromosome partitioning
H6S61_08775	COG0357	Ribosomal RNA small subunit methyltransferase G
H6S61_08780	COG0445	tRNA wobble uridine modification
H6S61_08785	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
H6S61_08795	COG0706	membrane insertase activity
H6S61_08805	COG0594	ribonuclease P activity
H6S61_08810	COG0230	Belongs to the bacterial ribosomal protein bL34 family
H6S61_08815	COG1126	abc transporter atp-binding protein
H6S61_08835	COG0592	DNA-directed DNA polymerase activity
H6S61_08845	COG0187	DNA topoisomerase II activity
H6S61_08850	COG0071	Belongs to the small heat shock protein (HSP20) family
H6S61_08860	COG3977	Valine--pyruvate aminotransferase
H6S61_08870	COG0751	glycine-tRNA ligase activity
H6S61_08875	COG0752	glycyl-tRNA synthetase alpha subunit
H6S61_08880	COG2119	membrane
H6S61_08890	COG0425	Belongs to the sulfur carrier protein TusA family
H6S61_08905	COG0604	alcohol dehydrogenase
H6S61_08910	COG0183	Belongs to the thiolase family
H6S61_08920	COG1739	Uncharacterized protein family UPF0029
H6S61_08925	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H6S61_08930	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
H6S61_08970	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
H6S61_08975	COG2960	long-chain fatty acid transporting porin activity
H6S61_08980	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H6S61_08985	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H6S61_08990	COG1309	transcriptional regulator
H6S61_09030	COG4172	Belongs to the ABC transporter superfamily
H6S61_09035	COG4166	transmembrane transport
H6S61_09040	COG0601	transmembrane transport
H6S61_09045	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H6S61_09080	COG0515	serine threonine protein kinase
H6S61_09080	COG2815	serine threonine protein kinase
H6S61_09090	COG0745	RESPONSE REGULATOR receiver
H6S61_09095	COG1609	Transcriptional regulator
H6S61_09100	COG0129	dihydroxy-acid dehydratase activity
H6S61_09105	COG3265	gluconokinase activity
H6S61_09110	COG2610	gluconate transmembrane transporter activity
H6S61_09115	COG0800	Aldolase
H6S61_09120	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H6S61_09125	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
H6S61_09135	COG1522	sequence-specific DNA binding
H6S61_09140	COG5001	Diguanylate cyclase
H6S61_09140	COG5002	protein histidine kinase activity
H6S61_09145	COG0742	ribosomal rna small subunit methyltransferase
H6S61_09160	COG0589	response to stress
H6S61_09165	COG1528	Iron-storage protein
H6S61_09175	COG2081	HI0933 family
H6S61_09185	COG2959	enzyme of heme biosynthesis
H6S61_09195	COG0181	hydroxymethylbilane synthase activity
H6S61_09200	COG3072	Adenylate cyclase
H6S61_09205	COG1965	Belongs to the frataxin family
H6S61_09215	COG0019	diaminopimelate decarboxylase activity
H6S61_09220	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
H6S61_09230	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
H6S61_09235	COG1011	Hydrolase
H6S61_09240	COG2199	diguanylate cyclase activity
H6S61_09240	COG2200	EAL domain
H6S61_09240	COG3287	FIST C domain
H6S61_09245	COG3148	PFAM DTW domain containing protein
H6S61_09260	COG0561	phosphatase activity
H6S61_09265	COG2267	carboxylic ester hydrolase activity
H6S61_09270	COG1280	lysine exporter protein (LysE YggA)
H6S61_09275	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
H6S61_09280	COG0640	Transcriptional regulator
H6S61_09285	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H6S61_09325	COG2095	MarC family integral membrane protein
H6S61_09335	COG0742	ribosomal rna small subunit methyltransferase
H6S61_09340	COG0552	protein localization to endoplasmic reticulum
H6S61_09345	COG2884	Cell division ATP-binding protein ftsE
H6S61_09350	COG2177	Part of the ABC transporter FtsEX involved in
H6S61_09360	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H6S61_09365	COG0705	Rhomboid family
H6S61_09370	COG1580	Controls the rotational direction of flagella during chemotaxis
H6S61_09375	COG3161	chorismate lyase activity
H6S61_09385	COG2937	Belongs to the GPAT DAPAT family
H6S61_09390	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H6S61_09400	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H6S61_09420	COG4206	TonB-dependent receptor
H6S61_09500	COG3344	reverse transcriptase
H6S61_09520	COG1322	Protein conserved in bacteria
H6S61_09525	COG2226	methyltransferase
H6S61_09530	COG3165	ubiquinone biosynthetic process from chorismate
H6S61_09540	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H6S61_09545	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H6S61_09550	COG0805	protein transport
H6S61_09555	COG0084	hydrolase, TatD family'
H6S61_09565	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H6S61_09565	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H6S61_09570	COG0218	Necessary for normal cell division and for the maintenance of normal septation
H6S61_09600	COG5001	Diguanylate cyclase
H6S61_09600	COG3300	MHYT domain
H6S61_09610	COG3852	Histidine kinase
H6S61_09620	COG0174	glutamine synthetase
H6S61_09625	COG1217	gtp-binding protein TYPA
H6S61_09640	COG1295	ribonuclease BN
H6S61_09645	COG1490	D-aminoacyl-tRNA deacylase activity
H6S61_09650	COG0456	acetyltransferase
H6S61_09665	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
H6S61_09670	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
H6S61_09675	COG3031	protein transport across the cell outer membrane
H6S61_09685	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H6S61_09690	COG1459	type II secretion system
H6S61_09695	COG2165	general secretion pathway protein
H6S61_09700	COG2165	general secretion pathway protein
H6S61_09705	COG2165	general secretion pathway protein
H6S61_09710	COG4795	General secretion pathway protein
H6S61_09715	COG3156	type II secretion system protein K
H6S61_09720	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
H6S61_09725	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
H6S61_09735	COG1218	3'(2'),5'-bisphosphate nucleotidase
H6S61_09740	COG0494	nUDIX hydrolase
H6S61_09745	COG0316	Belongs to the HesB IscA family
H6S61_09745	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
H6S61_09755	COG0596	Alpha beta hydrolase
H6S61_09765	COG3344	reverse transcriptase
H6S61_09770	COG2183	response to ionizing radiation
H6S61_09790	COG2233	PERMEase
H6S61_09795	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
H6S61_09800	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H6S61_09805	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H6S61_09810	COG1758	RNA polymerase activity
H6S61_09815	COG0194	GDP metabolic process
H6S61_09830	COG0848	biopolymer transport protein
H6S61_09835	COG0811	peptide transport
H6S61_09840	COG0811	peptide transport
H6S61_09850	COG4206	TonB-dependent receptor
H6S61_09855	COG4174	ABC transporter (Permease)
H6S61_09860	COG4239	(ABC) transporter, permease
H6S61_09865	COG0747	negative chemotaxis
H6S61_09870	COG0444	Belongs to the ABC transporter superfamily
H6S61_09875	COG4608	Belongs to the ABC transporter superfamily
H6S61_09890	COG0653	protein targeting
H6S61_09905	COG1561	YicC-like family, N-terminal region
H6S61_09910	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
H6S61_09920	COG1560	Kdo2-lipid A biosynthetic process
H6S61_09925	COG1309	transcriptional regulator
H6S61_09935	COG0840	transmembrane signaling receptor activity
H6S61_09940	COG2003	Belongs to the UPF0758 family
H6S61_09945	COG0227	Belongs to the bacterial ribosomal protein bL28 family
H6S61_09950	COG0267	Belongs to the bacterial ribosomal protein bL33 family
H6S61_09960	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
H6S61_09970	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
H6S61_09975	COG0859	PFAM glycosyl transferase family 9
H6S61_09980	COG0463	Glycosyl transferase, family 2
H6S61_09985	COG0859	PFAM glycosyl transferase family 9
H6S61_09990	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
H6S61_09995	COG3642	lipopolysaccharide core region biosynthetic process
H6S61_10000	COG3083	sulfuric ester hydrolase activity
H6S61_10015	COG1086	Polysaccharide biosynthesis protein
H6S61_10020	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
H6S61_10030	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
H6S61_10035	COG0107	imidazoleglycerol-phosphate synthase activity
H6S61_10040	COG1083	cytidylyl-transferase
H6S61_10050	COG2089	acid synthase
H6S61_10060	COG1519	Transferase
H6S61_10100	COG1596	polysaccharide export
H6S61_10140	COG2244	polysaccharide biosynthetic process
H6S61_10175	COG1215	transferase activity, transferring glycosyl groups
H6S61_10195	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H6S61_10215	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
H6S61_10220	COG0088	Forms part of the polypeptide exit tunnel
H6S61_10225	COG0089	rRNA binding
H6S61_10230	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
H6S61_10235	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
H6S61_10245	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
H6S61_10250	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
H6S61_10255	COG0255	Belongs to the universal ribosomal protein uL29 family
H6S61_10260	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
H6S61_10265	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
H6S61_10270	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
H6S61_10275	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
H6S61_10280	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
H6S61_10285	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
H6S61_10290	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
H6S61_10295	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
H6S61_10300	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
H6S61_10305	COG1841	ribosomal large subunit assembly
H6S61_10310	COG0200	Binds to the 23S rRNA
H6S61_10315	COG0201	protein transport
H6S61_10320	COG0257	Belongs to the bacterial ribosomal protein bL36 family
H6S61_10325	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
H6S61_10330	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
H6S61_10335	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
H6S61_10340	COG0202	RNA polymerase activity
H6S61_10345	COG0203	ribosomal protein L17
H6S61_10355	COG0545	Peptidyl-prolyl cis-trans isomerase
H6S61_10360	COG3266	domain, Protein
H6S61_10360	COG3061	Opacity-associated protein A
H6S61_10370	COG2153	protein acetylation
H6S61_10380	COG0737	Belongs to the 5'-nucleotidase family
H6S61_10385	COG1648	precorrin-2 dehydrogenase activity
H6S61_10385	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H6S61_10390	COG0175	sulfate reduction
H6S61_10395	COG2895	sulfate adenylyltransferase (ATP) activity
H6S61_10400	COG3273	potassium ion transport
H6S61_10400	COG0471	metal ion transport
H6S61_10405	COG0529	Catalyzes the synthesis of activated sulfate
H6S61_10425	COG1136	(ABC) transporter
H6S61_10425	COG0577	efflux transmembrane transporter activity
H6S61_10440	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
H6S61_10455	COG0729	surface antigen
H6S61_10460	COG2911	Protein conserved in bacteria
H6S61_10465	COG2105	PFAM AIG2 family protein
H6S61_10475	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
H6S61_10480	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
H6S61_10485	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H6S61_10490	COG0163	prenyltransferase activity
H6S61_10495	COG4143	(ABC) transporter
H6S61_10500	COG1178	ABC-type Fe3 transport system permease component
H6S61_10505	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
H6S61_10510	COG3028	Belongs to the UPF0307 family
H6S61_10520	COG2239	Acts as a magnesium transporter
H6S61_10525	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H6S61_10530	COG1660	Displays ATPase and GTPase activities
H6S61_10535	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H6S61_10540	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
H6S61_10550	COG1137	ATPase activity
H6S61_10555	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
H6S61_10565	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
H6S61_10570	COG0517	IMP dehydrogenase activity
H6S61_10570	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
H6S61_10580	COG1127	ABC transporter
H6S61_10585	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
H6S61_10590	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
H6S61_10595	COG2854	intermembrane phospholipid transfer
H6S61_10605	COG5007	Belongs to the BolA IbaG family
H6S61_10615	COG0204	Acyl-transferase
H6S61_10620	COG0589	response to stress
H6S61_10630	COG2358	TRAP transporter, solute receptor (TAXI family
H6S61_10635	COG1438	arginine binding
H6S61_10640	COG0039	L-malate dehydrogenase activity
H6S61_10645	COG0142	geranyltranstransferase activity
H6S61_10650	COG0261	This protein binds to 23S rRNA in the presence of protein L20
H6S61_10655	COG0211	Belongs to the bacterial ribosomal protein bL27 family
H6S61_10665	COG2966	Psort location CytoplasmicMembrane, score
H6S61_10670	COG3610	response to peptide
H6S61_10685	COG2967	ApaG domain
H6S61_10690	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
H6S61_10695	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
H6S61_10720	COG0066	3-isopropylmalate dehydratase activity
H6S61_10730	COG0473	3-isopropylmalate dehydrogenase activity
H6S61_10735	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H6S61_10760	COG1022	Amp-dependent synthetase and ligase
H6S61_10765	COG0028	Belongs to the TPP enzyme family
H6S61_10770	COG0440	acetolactate synthase activity
H6S61_10775	COG3706	GGDEF domain
H6S61_10790	COG1349	DNA-binding transcription factor activity
H6S61_10795	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H6S61_10800	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
H6S61_10815	COG3550	peptidyl-serine autophosphorylation
H6S61_10840	COG1610	YqeY-like protein
H6S61_10845	COG0828	Belongs to the bacterial ribosomal protein bS21 family
H6S61_10850	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
H6S61_10855	COG0596	Alpha beta hydrolase
H6S61_10865	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
H6S61_10870	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
H6S61_10875	COG1968	undecaprenyl-diphosphatase activity
H6S61_10880	COG0617	tRNA 3'-terminal CCA addition
H6S61_10885	COG3409	Peptidoglycan-binding domain 1 protein
H6S61_10885	COG3267	Type II secretory pathway component ExeA
H6S61_10890	COG4991	sh3 domain protein
H6S61_10895	COG0306	phosphate transporter
H6S61_10900	COG1392	Phosphate transport regulator
H6S61_10905	COG3025	triphosphatase activity
H6S61_10910	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H6S61_10920	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
H6S61_10930	COG1538	Outer membrane efflux protein
H6S61_10935	COG0494	nUDIX hydrolase
H6S61_10940	COG3151	Protein conserved in bacteria
H6S61_10950	COG3150	esterase
H6S61_10965	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H6S61_10970	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H6S61_10975	COG3105	Protein conserved in bacteria
H6S61_10980	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
H6S61_10985	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
H6S61_10990	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
H6S61_10995	COG0723	plastoquinol--plastocyanin reductase activity
H6S61_11000	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
H6S61_11005	COG2857	Cytochrome c1
H6S61_11010	COG0625	glutathione transferase activity
H6S61_11015	COG2969	positive regulation of protein catabolic process
H6S61_11025	COG2823	Periplasmic or secreted lipoprotein
H6S61_11030	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
H6S61_11035	COG0792	nuclease activity
H6S61_11040	COG3107	peptidoglycan biosynthetic process
H6S61_11045	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
H6S61_11055	COG0275	rRNA processing
H6S61_11060	COG3116	cell division
H6S61_11065	COG0768	penicillin binding
H6S61_11075	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
H6S61_11080	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H6S61_11090	COG0772	Belongs to the SEDS family
H6S61_11100	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H6S61_11105	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
H6S61_11110	COG0849	cell division
H6S61_11115	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
H6S61_11120	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
H6S61_11130	COG0653	protein targeting
H6S61_11135	COG0494	nUDIX hydrolase
H6S61_11145	COG0505	Belongs to the CarA family
H6S61_11150	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
H6S61_11160	COG0730	response to heat
H6S61_11165	COG0583	DNA-binding transcription factor activity
H6S61_11170	COG2860	membrane
H6S61_11175	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H6S61_11185	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
H6S61_11195	COG0493	'glutamate synthase
H6S61_11200	COG0067	glutamate synthase
H6S61_11200	COG0069	glutamate synthase activity
H6S61_11200	COG0070	glutamate synthase
H6S61_11210	COG0070	glutamate synthase
H6S61_11210	COG0067	glutamate synthase
H6S61_11210	COG0069	glutamate synthase activity
H6S61_11215	COG1242	4 iron, 4 sulfur cluster binding
H6S61_11220	COG2203	Gaf domain
H6S61_11220	COG3706	GGDEF domain
H6S61_11220	COG4251	negative regulation of phosphorylation
H6S61_11220	COG5001	Diguanylate cyclase
H6S61_11225	COG5002	protein histidine kinase activity
H6S61_11225	COG0784	Response regulator, receiver
H6S61_11225	COG2198	Histidine kinase
H6S61_11235	COG0745	RESPONSE REGULATOR receiver
H6S61_11245	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H6S61_11260	COG0083	homoserine kinase activity
H6S61_11265	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
H6S61_11270	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
H6S61_11280	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
H6S61_11295	COG1115	amino acid carrier protein
H6S61_11300	COG3022	response to hydroperoxide
H6S61_11305	COG0513	Belongs to the DEAD box helicase family
H6S61_11325	COG4974	Belongs to the 'phage' integrase family
H6S61_11330	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H6S61_11335	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
H6S61_11345	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
H6S61_11365	COG0667	Aldo Keto reductase
H6S61_11375	COG3066	DNA modification
H6S61_11380	COG0494	nUDIX hydrolase
H6S61_11390	COG0730	response to heat
H6S61_11410	COG1283	sodium-dependent phosphate transmembrane transporter activity
H6S61_11415	COG0583	DNA-binding transcription factor activity
H6S61_11420	COG0640	Transcriptional regulator
H6S61_11425	COG0268	Binds directly to 16S ribosomal RNA
H6S61_11430	COG0728	peptidoglycan biosynthetic process
H6S61_11435	COG0196	riboflavin kinase activity
H6S61_11440	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
H6S61_11445	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
H6S61_11450	COG1047	Peptidyl-prolyl cis-trans
H6S61_11455	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
H6S61_11465	COG3275	phosphorelay sensor kinase activity
H6S61_11470	COG1966	Carbon starvation protein
H6S61_11485	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
H6S61_11500	COG0287	Prephenate dehydrogenase
H6S61_11500	COG1605	Chorismate mutase
H6S61_11505	COG0739	heme binding
H6S61_11515	COG0488	(ABC) transporter
H6S61_11525	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
H6S61_11530	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
H6S61_11535	COG0077	Prephenate dehydratase
H6S61_11535	COG1605	Chorismate mutase
H6S61_11540	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
H6S61_11545	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H6S61_11560	COG0542	response to heat
H6S61_11600	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H6S61_11605	COG0826	peptidase U32
H6S61_11615	COG0745	RESPONSE REGULATOR receiver
H6S61_11620	COG5002	protein histidine kinase activity
H6S61_11630	COG0248	Ppx GppA phosphatase
H6S61_11640	COG0573	inorganic phosphate transmembrane transporter activity
H6S61_11650	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H6S61_11655	COG0704	Plays a role in the regulation of phosphate uptake
H6S61_11670	COG0450	alkyl hydroperoxide reductase
H6S61_11675	COG0583	DNA-binding transcription factor activity
H6S61_11680	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
H6S61_11690	COG0517	IMP dehydrogenase activity
H6S61_11700	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
H6S61_11705	COG0343	queuine tRNA-ribosyltransferase activity
H6S61_11710	COG1862	Preprotein translocase
H6S61_11715	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H6S61_11720	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H6S61_11725	COG0483	inositol monophosphate 1-phosphatase activity
H6S61_11730	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
H6S61_11735	COG1959	2 iron, 2 sulfur cluster binding
H6S61_11745	COG0822	iron-sulfur transferase activity
H6S61_11750	COG0316	Belongs to the HesB IscA family
H6S61_11760	COG0443	Heat shock 70 kDa protein
H6S61_11765	COG0633	Ferredoxin
H6S61_11770	COG2975	iron-sulfur cluster assembly
H6S61_11775	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
H6S61_11780	COG0105	UTP biosynthetic process
H6S61_11795	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
H6S61_11800	COG0124	histidyl-tRNA synthetase
H6S61_11805	COG2976	Protein conserved in bacteria
H6S61_11810	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H6S61_11825	COG2199	diguanylate cyclase activity
H6S61_11825	COG2203	Gaf domain
H6S61_11835	COG1570	exodeoxyribonuclease VII activity
H6S61_11840	COG0517	IMP dehydrogenase activity
H6S61_11840	COG0516	GMP reductase activity
H6S61_11845	COG0519	Catalyzes the synthesis of GMP from XMP
H6S61_11845	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H6S61_11855	COG1584	GPR1 FUN34 yaaH family protein
H6S61_11860	COG1115	amino acid carrier protein
H6S61_11870	COG0583	DNA-binding transcription factor activity
H6S61_11885	COG0009	L-threonylcarbamoyladenylate synthase
H6S61_11985	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
H6S61_12025	COG0582	viral genome integration into host DNA
H6S61_12035	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
H6S61_12040	COG2867	negative regulation of translational initiation
H6S61_12045	COG2914	Belongs to the UPF0125 (RnfH) family
H6S61_12050	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H6S61_12055	COG0497	DNA recombination
H6S61_12060	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
H6S61_12065	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
H6S61_12095	COG0443	Heat shock 70 kDa protein
H6S61_12100	COG0484	heat shock protein binding
H6S61_12130	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
H6S61_12135	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
H6S61_12140	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
H6S61_12145	COG0583	DNA-binding transcription factor activity
H6S61_12155	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
H6S61_12185	COG2195	Cleaves the N-terminal amino acid of tripeptides
H6S61_12190	COG2252	PERMEase
H6S61_12195	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
H6S61_12200	COG1073	alpha beta
H6S61_12210	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
H6S61_12220	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
H6S61_12225	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H6S61_12225	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H6S61_12240	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
H6S61_12245	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H6S61_12250	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
H6S61_12255	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
H6S61_12265	COG0142	geranyltranstransferase activity
H6S61_12270	COG1722	exodeoxyribonuclease VII activity
H6S61_12275	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
H6S61_12300	COG0583	DNA-binding transcription factor activity
H6S61_12310	COG2363	Small membrane protein
H6S61_12325	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H6S61_12330	COG1611	Belongs to the LOG family
H6S61_12355	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
H6S61_12360	COG1464	Belongs to the NlpA lipoprotein family
H6S61_12365	COG2011	ABC-type metal ion transport system permease component
H6S61_12370	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H6S61_12375	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
H6S61_12385	COG1263	PTS System
H6S61_12385	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H6S61_12390	COG0366	Alpha amylase catalytic
H6S61_12420	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
H6S61_12430	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
H6S61_12435	COG0321	lipoyl(octanoyl) transferase activity
H6S61_12440	COG2921	Belongs to the UPF0250 family
H6S61_12445	COG1686	Belongs to the peptidase S11 family
H6S61_12450	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
H6S61_12455	COG0772	Belongs to the SEDS family
H6S61_12460	COG0768	penicillin binding
H6S61_12465	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
H6S61_12470	COG0799	negative regulation of ribosome biogenesis
H6S61_12475	COG1466	dna polymerase III delta subunit
H6S61_12480	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
H6S61_12490	COG2888	peptidyl-tyrosine sulfation
H6S61_12500	COG4535	Mg2 and Co2 transporter CorC
H6S61_12505	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
H6S61_12510	COG1702	phosphate starvation-inducible protein PhoH
H6S61_12515	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H6S61_12520	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H6S61_12525	COG3344	reverse transcriptase
H6S61_12610	COG0193	aminoacyl-tRNA hydrolase activity
H6S61_12615	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H6S61_12620	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
H6S61_12635	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
H6S61_12640	COG2890	protein-(glutamine-N5) methyltransferase activity
H6S61_12650	COG2912	Transglutaminase-like superfamily
H6S61_12655	COG2877	3-deoxy-8-phosphooctulonate synthase activity
H6S61_12670	COG1187	pseudouridine synthase activity
H6S61_12675	COG2840	Smr protein MutS2
H6S61_12690	COG3735	TraB family
H6S61_12705	COG2217	Heavy metal translocating P-type atpase
H6S61_12705	COG2608	mercury ion transmembrane transporter activity
H6S61_12765	COG0835	chemotaxis
H6S61_12765	COG0784	Response regulator, receiver
H6S61_12770	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
H6S61_12775	COG1815	bacterial-type flagellum-dependent cell motility
H6S61_12790	COG1749	Flagellar hook protein flgE
H6S61_12795	COG4787	bacterial-type flagellum-dependent cell motility
H6S61_12810	COG1706	bacterial-type flagellum-dependent cell motility
H6S61_12815	COG3951	Flagellar rod assembly protein muramidase FlgJ
H6S61_12815	COG1705	Flagellar rod assembly protein muramidase FlgJ
H6S61_12825	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H6S61_12830	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H6S61_12835	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H6S61_12840	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H6S61_12845	COG2190	(PTS) system
H6S61_12850	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H6S61_12855	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H6S61_12860	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
H6S61_12865	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
H6S61_12895	COG0330	HflC and HflK could
H6S61_12900	COG3118	belongs to the thioredoxin family
H6S61_12905	COG0300	oxidoreductase activity
H6S61_12910	COG1090	epimerase
H6S61_12935	COG0622	Phosphoesterase
H6S61_12955	COG3710	Transcriptional regulator
H6S61_12960	COG0326	Molecular chaperone. Has ATPase activity
H6S61_12970	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
H6S61_12980	COG3104	oligopeptide transport
H6S61_12990	COG0367	asparagine synthase
H6S61_13000	COG4651	solute:proton antiporter activity
H6S61_13000	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H6S61_13005	COG1846	Transcriptional regulator
H6S61_13005	COG1940	carbohydrate kinase activity
H6S61_13010	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
H6S61_13015	COG2190	(PTS) system
H6S61_13015	COG1263	PTS System
H6S61_13015	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H6S61_13020	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H6S61_13035	COG0716	FMN binding
H6S61_13045	COG0596	Alpha beta hydrolase
H6S61_13050	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
H6S61_13055	COG0033	Phosphoglucomutase
H6S61_13060	COG2964	Protein conserved in bacteria
H6S61_13065	COG0251	oxidation-reduction process
H6S61_13075	COG0446	pyridine nucleotide-disulphide oxidoreductase
H6S61_13085	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
H6S61_13095	COG2009	succinate dehydrogenase
H6S61_13100	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
H6S61_13105	COG1053	succinate dehydrogenase
H6S61_13115	COG0567	Dehydrogenase, E1 component
H6S61_13120	COG0508	dehydrogenase complex catalyzes the overall conversion of
H6S61_13135	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H6S61_13140	COG1121	(ABC) transporter
H6S61_13145	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
H6S61_13155	COG1918	ferrous iron import across plasma membrane
H6S61_13180	COG3102	Protein conserved in bacteria
H6S61_13185	COG0788	formyltetrahydrofolate deformylase activity
H6S61_13195	COG1199	ATP-dependent helicase activity
H6S61_13200	COG1214	PFAM Peptidase M22, glycoprotease
H6S61_13215	COG0596	Alpha beta hydrolase
H6S61_13220	COG0318	PFAM AMP-dependent synthetase and ligase
H6S61_13225	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
H6S61_13230	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
H6S61_13235	COG2894	cell division
H6S61_13240	COG0850	regulation of cytokinetic process
H6S61_13250	COG2951	lytic endotransglycosylase activity
H6S61_13260	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
H6S61_13270	COG0745	RESPONSE REGULATOR receiver
H6S61_13275	COG5002	protein histidine kinase activity
H6S61_13290	COG1028	Short-chain dehydrogenase reductase Sdr
H6S61_13300	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H6S61_13325	COG2986	histidine ammonia-lyase
H6S61_13330	COG1216	Glycosyl transferase, family 2
H6S61_13350	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H6S61_13355	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H6S61_13415	COG1175	transmembrane transport
H6S61_13425	COG3842	ATPase activity
H6S61_13430	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
H6S61_13435	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
H6S61_13440	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
H6S61_13445	COG2204	response regulator
H6S61_13450	COG4191	Histidine kinase
H6S61_13455	COG0544	peptidyl-prolyl cis-trans isomerase activity
H6S61_13465	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
H6S61_13470	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
H6S61_13475	COG0776	regulation of translation
H6S61_13480	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H6S61_13485	COG1555	photosystem II stabilization
H6S61_13495	COG3148	PFAM DTW domain containing protein
H6S61_13500	COG0232	Belongs to the dGTPase family. Type 2 subfamily
H6S61_13505	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
H6S61_13510	COG0436	Aminotransferase
H6S61_13515	COG1169	isochorismate synthase
H6S61_13525	COG0596	Alpha beta hydrolase
H6S61_13530	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
H6S61_13540	COG0318	PFAM AMP-dependent synthetase and ligase
H6S61_13600	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H6S61_13625	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
H6S61_13630	COG1522	sequence-specific DNA binding
H6S61_13640	COG1946	Acyl-CoA thioesterase
H6S61_13645	COG3126	Type III secretion system lipoprotein chaperone (YscW)
H6S61_13675	COG0330	HflC and HflK could
H6S61_13715	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H6S61_13730	COG3139	Protein of unknown function (DUF1315)
H6S61_13735	COG0252	asparaginase activity
H6S61_13740	COG0616	signal peptide processing
H6S61_13745	COG0446	pyridine nucleotide-disulphide oxidoreductase
H6S61_13745	COG1902	pentaerythritol trinitrate reductase activity
H6S61_13750	COG0778	Nitroreductase
H6S61_13755	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H6S61_13760	COG0123	including yeast histone deacetylase and acetoin utilization protein
H6S61_13765	COG2205	protein histidine kinase activity
H6S61_13765	COG0784	Response regulator, receiver
H6S61_13775	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H6S61_13780	COG2731	YhcH YjgK YiaL family protein
H6S61_13785	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H6S61_13790	COG0569	domain protein
H6S61_13805	COG1396	sequence-specific DNA binding
H6S61_13815	COG3083	sulfuric ester hydrolase activity
H6S61_13820	COG3082	Protein of unknown function (DUF1414)
H6S61_13825	COG3081	Nucleoid-associated protein
H6S61_13840	COG1757	Na H antiporter
H6S61_13845	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
H6S61_13855	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H6S61_13860	COG2095	MarC family integral membrane protein
H6S61_13865	COG1454	alcohol dehydrogenase
H6S61_13865	COG1012	belongs to the aldehyde dehydrogenase family
H6S61_13875	COG1028	Short-chain dehydrogenase reductase Sdr
H6S61_13890	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
H6S61_13900	COG2056	Na+-H+ antiporter family
H6S61_13905	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H6S61_13910	COG2885	chlorophyll binding
H6S61_13920	COG0346	lactoylglutathione lyase activity
H6S61_13925	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
H6S61_13930	COG4660	Part of a membrane complex involved in electron transport
H6S61_13935	COG4659	FMN binding
H6S61_13945	COG4656	Part of a membrane complex involved in electron transport
H6S61_13950	COG2878	Part of a membrane complex involved in electron transport
H6S61_13955	COG4657	Part of a membrane complex involved in electron transport
H6S61_13965	COG0556	nucleotide-excision repair
H6S61_13970	COG2204	response regulator
H6S61_13975	COG2198	Histidine kinase
H6S61_13980	COG0391	Required for morphogenesis under gluconeogenic growth conditions
H6S61_13990	COG0521	Mo-molybdopterin cofactor biosynthetic process
H6S61_13995	COG0315	cyclic pyranopterin monophosphate synthase activity
H6S61_14000	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
H6S61_14005	COG0314	molybdopterin synthase activity
H6S61_14015	COG0601	transmembrane transport
H6S61_14020	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H6S61_14025	COG0444	Belongs to the ABC transporter superfamily
H6S61_14035	COG0435	Glutathione S-transferase
H6S61_14045	COG2350	Protein conserved in bacteria
H6S61_14065	COG1301	dicarboxylic acid transport
H6S61_14075	COG0133	tryptophan synthase activity
H6S61_14080	COG0135	phosphoribosylanthranilate isomerase activity
H6S61_14080	COG0134	indole-3-glycerol-phosphate synthase activity
H6S61_14090	COG0512	Glutamine amidotransferase of anthranilate synthase
H6S61_14095	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
H6S61_14105	COG0613	PHP domain protein
H6S61_14110	COG0009	L-threonylcarbamoyladenylate synthase
H6S61_14130	COG3344	reverse transcriptase
H6S61_14140	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
H6S61_14150	COG5001	Diguanylate cyclase
H6S61_14155	COG0417	DNA replication proofreading
H6S61_14160	COG2197	response regulator
H6S61_14165	COG0322	excinuclease ABC activity
H6S61_14230	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H6S61_14235	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H6S61_14240	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H6S61_14260	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
H6S61_14265	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
H6S61_14270	COG0437	4 iron, 4 sulfur cluster binding
H6S61_14275	COG3301	Polysulphide reductase, NrfD
H6S61_14280	COG1138	Cytochrome C-type biogenesis protein
H6S61_14285	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H6S61_14290	COG3088	subunit of a heme lyase
H6S61_14305	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H6S61_14305	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H6S61_14310	COG0489	protein tyrosine kinase activity
H6S61_14315	COG0572	uridine kinase
H6S61_14325	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
H6S61_14330	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H6S61_14335	COG0659	secondary active sulfate transmembrane transporter activity
H6S61_14340	COG1530	ribonuclease E activity
H6S61_14350	COG0424	maF-like protein
H6S61_14355	COG1399	metal-binding, possibly nucleic acid-binding protein
H6S61_14360	COG0333	Belongs to the bacterial ribosomal protein bL32 family
H6S61_14365	COG0416	fatty acid biosynthetic process
H6S61_14370	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H6S61_14385	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H6S61_14400	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
H6S61_14405	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
H6S61_14420	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H6S61_14420	COG1263	PTS System
H6S61_14435	COG0733	neurotransmitter:sodium symporter activity
H6S61_14450	COG4667	esterase of the alpha-beta hydrolase superfamily
H6S61_14455	COG0469	pyruvate kinase activity
H6S61_14460	COG1940	carbohydrate kinase activity
H6S61_14465	COG0784	Response regulator, receiver
H6S61_14465	COG0835	chemotaxis
H6S61_14470	COG0587	DNA-directed DNA polymerase activity
H6S61_14485	COG1028	Short-chain dehydrogenase reductase Sdr
H6S61_14490	COG0616	signal peptide processing
H6S61_14500	COG0539	negative regulation of cytoplasmic translation
H6S61_14510	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
H6S61_14515	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
H6S61_14520	COG0284	orotidine-5'-phosphate decarboxylase activity
H6S61_14525	COG4174	ABC transporter (Permease)
H6S61_14530	COG4239	(ABC) transporter, permease
H6S61_14535	COG4166	transmembrane transport
H6S61_14540	COG0444	Belongs to the ABC transporter superfamily
H6S61_14545	COG4608	Belongs to the ABC transporter superfamily
H6S61_14570	COG0583	DNA-binding transcription factor activity
H6S61_14580	COG0686	Belongs to the AlaDH PNT family
H6S61_14595	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
H6S61_14600	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
H6S61_14615	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
H6S61_14630	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
H6S61_14640	COG0501	Belongs to the peptidase M48B family
H6S61_14650	COG1028	Short-chain dehydrogenase reductase Sdr
H6S61_14665	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
H6S61_14685	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
H6S61_14690	COG2915	High frequency lysogenization protein hflD homolog
H6S61_14695	COG0482	sulfurtransferase activity
H6S61_14705	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H6S61_14710	COG2916	Histone family protein nucleoid-structuring protein H-NS
H6S61_14715	COG1757	Na H antiporter
H6S61_14720	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
H6S61_14725	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
H6S61_14730	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H6S61_14735	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
H6S61_14735	COG0131	Imidazoleglycerol-phosphate dehydratase
H6S61_14740	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
H6S61_14745	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
H6S61_14760	COG3012	SEC-C Motif Domain Protein
H6S61_14765	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
H6S61_14770	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H6S61_14775	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H6S61_14785	COG1435	thymidine kinase activity
H6S61_14795	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H6S61_14800	COG0583	DNA-binding transcription factor activity
H6S61_14820	COG2116	formate transmembrane transporter activity
H6S61_14825	COG0390	transport system, permease component
H6S61_14830	COG4459	periplasmic nitrate reductase
H6S61_14835	COG3005	denitrification pathway
H6S61_14840	COG0243	molybdopterin cofactor binding
H6S61_14870	COG1227	inorganic diphosphatase activity
H6S61_14885	COG4172	Belongs to the ABC transporter superfamily
H6S61_14910	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
H6S61_14915	COG1842	Phage shock protein A
H6S61_14925	COG1983	PspC domain protein
H6S61_14945	COG2818	Glycosylase
H6S61_14950	COG0626	cystathionine gamma-synthase activity
H6S61_14960	COG0733	neurotransmitter:sodium symporter activity
H6S61_14975	COG0564	pseudouridine synthase activity
H6S61_14985	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H6S61_14990	COG1151	hydroxylamine reductase activity
H6S61_14995	COG3604	Transcriptional regulator
H6S61_15000	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
H6S61_15005	COG4136	ATPase activity
H6S61_15010	COG4135	transport system, permease component
H6S61_15015	COG4134	Bacterial extracellular solute-binding protein
H6S61_15025	COG3313	Fe-S protein
H6S61_15050	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
H6S61_15055	COG2205	protein histidine kinase activity
H6S61_15070	COG1061	Type III restriction enzyme res subunit
H6S61_15080	COG2814	Major facilitator Superfamily
H6S61_15090	COG0702	epimerase
H6S61_15110	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
H6S61_15125	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
H6S61_15130	COG2985	domain, Protein
H6S61_15130	COG3273	potassium ion transport
H6S61_15135	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
H6S61_15140	COG1979	alcohol dehydrogenase
H6S61_15145	COG1737	Transcriptional regulator
H6S61_15150	COG0076	glutamate decarboxylase activity
H6S61_15160	COG2431	L-lysine efflux transmembrane transporter activity
H6S61_15170	COG3070	regulator of competence-specific genes
H6S61_15185	COG5002	protein histidine kinase activity
H6S61_15185	COG5002	protein histidine kinase activity
H6S61_15200	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
H6S61_15205	COG4988	ABC transporter
H6S61_15210	COG0492	ferredoxin-NADP+ reductase activity
H6S61_15220	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
H6S61_15235	COG0471	metal ion transport
H6S61_15240	COG2949	membrane
H6S61_15245	COG0281	malic enzyme
H6S61_15250	COG1643	Atp-dependent helicase
H6S61_15265	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
H6S61_15275	COG1346	cytolysis
H6S61_15280	COG1380	Effector of murein hydrolase LrgA
H6S61_15285	COG2925	Exonuclease
H6S61_15300	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
H6S61_15330	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
H6S61_15360	COG1451	nucleotide metabolic process
H6S61_15375	COG3063	Type IV pilus biogenesis stability protein PilW
H6S61_15380	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
H6S61_15385	COG0737	Belongs to the 5'-nucleotidase family
H6S61_15390	COG2195	Cleaves the N-terminal amino acid of tripeptides
H6S61_15400	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
H6S61_15410	COG0625	glutathione transferase activity
H6S61_15450	COG1278	Cold shock
H6S61_15460	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
H6S61_15465	COG0584	glycerophosphoryl diester phosphodiesterase
H6S61_15470	COG1349	DNA-binding transcription factor activity
H6S61_15475	COG3842	ATPase activity
H6S61_15480	COG0395	ABC-type sugar transport system, permease component
H6S61_15485	COG1175	transmembrane transport
H6S61_15500	COG0730	response to heat
H6S61_15510	COG2197	response regulator
H6S61_15550	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
H6S61_15560	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
H6S61_15565	COG0372	Belongs to the citrate synthase family
H6S61_15570	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
H6S61_15575	COG2828	Protein conserved in bacteria
H6S61_15630	COG0561	phosphatase activity
H6S61_15635	COG0602	queuosine metabolic process
H6S61_15640	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
H6S61_15645	COG3706	GGDEF domain
H6S61_15675	COG4989	oxidoreductase activity
H6S61_15685	COG2195	Cleaves the N-terminal amino acid of tripeptides
H6S61_15705	COG0840	transmembrane signaling receptor activity
H6S61_15710	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H6S61_15715	COG0545	Peptidyl-prolyl cis-trans isomerase
H6S61_15745	COG1278	Cold shock
H6S61_15750	COG3036	rescue of stalled ribosome
H6S61_15760	COG2203	Gaf domain
H6S61_15760	COG2199	diguanylate cyclase activity
H6S61_15770	COG1482	cell wall glycoprotein biosynthetic process
H6S61_15775	COG2271	Major facilitator Superfamily
H6S61_15780	COG3851	Histidine kinase
H6S61_15785	COG2197	response regulator
H6S61_15800	COG0457	Tetratricopeptide repeat
H6S61_15800	COG3710	Transcriptional regulator
H6S61_15815	COG2130	NADP-dependent
H6S61_15820	COG1309	transcriptional regulator
H6S61_15835	COG1278	Cold shock
H6S61_15855	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
H6S61_15860	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H6S61_15865	COG1960	acyl-CoA dehydrogenase activity
H6S61_15875	COG0183	Belongs to the thiolase family
H6S61_15890	COG1024	Enoyl-CoA hydratase
H6S61_15895	COG1024	Enoyl-CoA hydratase
H6S61_15905	COG1028	Short-chain dehydrogenase reductase Sdr
H6S61_15930	COG2994	toxin metabolic process
H6S61_15990	COG3437	response regulator, receiver
H6S61_15990	COG0784	Response regulator, receiver
H6S61_15995	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H6S61_15995	COG4191	Histidine kinase
H6S61_16005	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
H6S61_16035	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H6S61_16040	COG3186	Phenylalanine-4-hydroxylase
H6S61_16045	COG2154	pterin-4-alpha-carbinolamine dehydratase
H6S61_16065	COG3530	Putative quorum-sensing-regulated virulence factor
H6S61_16085	COG2815	serine threonine protein kinase
H6S61_16085	COG0515	serine threonine protein kinase
H6S61_16120	COG0631	protein serine/threonine phosphatase activity
H6S61_16225	COG3209	COG3209 Rhs family protein
H6S61_16235	COG0501	Belongs to the peptidase M48B family
H6S61_16240	COG1704	LemA family
H6S61_16245	COG3069	C4-dicarboxylate transmembrane transporter activity
H6S61_16255	COG0312	modulator of DNA gyrase
H6S61_16260	COG0312	modulator of DNA gyrase
H6S61_16265	COG0584	glycerophosphoryl diester phosphodiesterase
H6S61_16270	COG2271	Major facilitator Superfamily
H6S61_16285	COG0840	transmembrane signaling receptor activity
H6S61_16290	COG0840	transmembrane signaling receptor activity
H6S61_16295	COG0366	Alpha amylase catalytic
H6S61_16305	COG0243	molybdopterin cofactor binding
H6S61_16310	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H6S61_16310	COG1648	precorrin-2 dehydrogenase activity
H6S61_16325	COG3707	response regulator
H6S61_16330	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H6S61_16330	COG1116	anion transmembrane transporter activity
H6S61_16335	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H6S61_16340	COG1116	anion transmembrane transporter activity
H6S61_16345	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H6S61_16345	COG2146	nitrite reductase [NAD(P)H] activity
H6S61_16360	COG2203	Gaf domain
H6S61_16360	COG2199	diguanylate cyclase activity
H6S61_16370	COG0523	cobalamin synthesis protein
H6S61_16380	COG0513	Belongs to the DEAD box helicase family
H6S61_16385	COG0010	Belongs to the arginase family
H6S61_16395	COG2203	Gaf domain
H6S61_16395	COG5001	Diguanylate cyclase
H6S61_16395	COG4251	negative regulation of phosphorylation
H6S61_16395	COG3706	GGDEF domain
H6S61_16405	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
H6S61_16430	COG0840	transmembrane signaling receptor activity
H6S61_16435	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H6S61_16470	COG0811	peptide transport
H6S61_16475	COG0811	peptide transport
H6S61_16480	COG0848	biopolymer transport protein
H6S61_16495	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
H6S61_16500	COG0840	transmembrane signaling receptor activity
H6S61_16515	COG0534	Mate efflux family protein
H6S61_16525	COG0477	Major facilitator Superfamily
H6S61_16530	COG3118	belongs to the thioredoxin family
H6S61_16535	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H6S61_16590	COG1328	CTP reductase activity
H6S61_16595	COG0602	queuosine metabolic process
H6S61_16605	COG4067	protein conserved in archaea
H6S61_16605	COG0189	ligase activity
H6S61_16625	COG0725	ABC transporter, periplasmic molybdate-binding protein
H6S61_16630	COG4149	molybdate abc transporter
H6S61_16640	COG0697	spore germination
H6S61_16645	COG1846	Transcriptional regulator
H6S61_16655	COG2199	diguanylate cyclase activity
H6S61_16665	COG3706	GGDEF domain
H6S61_16680	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
H6S61_16685	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
H6S61_16695	COG0745	RESPONSE REGULATOR receiver
H6S61_16710	COG3140	Belongs to the UPF0181 family
H6S61_16715	COG3344	reverse transcriptase
H6S61_16790	COG0023	Translation Initiation Factor
H6S61_16800	COG1181	Belongs to the D-alanine--D-alanine ligase family
H6S61_16810	COG0045	succinate-CoA ligase (ADP-forming) activity
H6S61_16810	COG1042	CoA-binding domain protein
H6S61_16810	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H6S61_16815	COG0583	DNA-binding transcription factor activity
H6S61_16825	COG3447	MASE1 domain protein
H6S61_16825	COG5001	Diguanylate cyclase
H6S61_16825	COG5002	protein histidine kinase activity
H6S61_16835	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
H6S61_16840	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
H6S61_16845	COG1984	allophanate hydrolase subunit 2
H6S61_16850	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H6S61_16850	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
H6S61_16855	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
H6S61_16860	COG4181	ATPase activity
H6S61_16870	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
H6S61_16875	COG1716	ATPase activity
H6S61_16875	COG5001	Diguanylate cyclase
H6S61_16890	COG0484	heat shock protein binding
H6S61_16910	COG0583	DNA-binding transcription factor activity
H6S61_16915	COG0366	Alpha amylase catalytic
H6S61_16925	COG4533	DNA binding
H6S61_16935	COG2050	protein possibly involved in aromatic compounds catabolism
H6S61_16950	COG2067	long-chain fatty acid transport protein
H6S61_16955	COG2267	carboxylic ester hydrolase activity
H6S61_16985	COG0861	Integral membrane protein TerC family
H6S61_16990	COG0737	Belongs to the 5'-nucleotidase family
H6S61_16995	COG3593	DNA synthesis involved in DNA repair
H6S61_17005	COG0583	DNA-binding transcription factor activity
H6S61_17010	COG2116	formate transmembrane transporter activity
H6S61_17015	COG2353	YceI-like domain
H6S61_17020	COG3038	cytochrome b561
H6S61_17035	COG0513	Belongs to the DEAD box helicase family
H6S61_17050	COG0546	phosphoglycolate phosphatase activity
H6S61_17055	COG0784	Response regulator, receiver
H6S61_17055	COG3437	response regulator, receiver
H6S61_17070	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H6S61_17075	COG2759	Belongs to the formate--tetrahydrofolate ligase family
H6S61_17080	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
H6S61_17090	COG2207	Transcriptional regulator
H6S61_17095	COG1979	alcohol dehydrogenase
H6S61_17105	COG4191	Histidine kinase
H6S61_17115	COG2271	Major facilitator Superfamily
H6S61_17120	COG0469	pyruvate kinase activity
H6S61_17145	COG1609	Transcriptional regulator
H6S61_17150	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
H6S61_17150	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H6S61_17155	COG1105	Belongs to the carbohydrate kinase PfkB family
H6S61_17160	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
H6S61_17160	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H6S61_17160	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H6S61_17205	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
H6S61_17210	COG0509	glycine decarboxylation via glycine cleavage system
H6S61_17215	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H6S61_17215	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H6S61_17230	COG1132	(ABC) transporter
H6S61_17245	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H6S61_17270	COG2814	Major facilitator Superfamily
H6S61_17300	COG0641	radical SAM
H6S61_17310	COG1524	type I phosphodiesterase nucleotide pyrophosphatase
H6S61_17345	COG0714	Associated with various cellular activities
H6S61_17365	COG3119	arylsulfatase activity
H6S61_17370	COG0604	alcohol dehydrogenase
H6S61_17375	COG1902	pentaerythritol trinitrate reductase activity
H6S61_17380	COG1902	pentaerythritol trinitrate reductase activity
H6S61_17385	COG0583	DNA-binding transcription factor activity
H6S61_17390	COG2814	Major facilitator Superfamily
H6S61_17400	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
H6S61_17410	COG0513	Belongs to the DEAD box helicase family
H6S61_17415	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
H6S61_17430	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
H6S61_17455	COG1716	ATPase activity
H6S61_17455	COG5001	Diguanylate cyclase
H6S61_17465	COG0513	Belongs to the DEAD box helicase family
H6S61_17480	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H6S61_17505	COG1879	ABC-type sugar transport system periplasmic component
H6S61_17510	COG1803	Methylglyoxal synthase
H6S61_17515	COG0210	DNA helicase
H6S61_17520	COG1289	transmembrane transporter activity
H6S61_17550	COG0789	Transcriptional regulator
H6S61_17555	COG4604	ABC transporter, ATP-binding protein
H6S61_17560	COG4605	iron ion homeostasis
H6S61_17565	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H6S61_17590	COG0110	maltose O-acetyltransferase activity
H6S61_17600	COG3290	protein histidine kinase activity
H6S61_17685	COG4964	Belongs to the GSP D family
H6S61_17705	COG0583	DNA-binding transcription factor activity
H6S61_17720	COG0419	ATPase involved in DNA repair
H6S61_17725	COG0420	3'-5' exonuclease activity
H6S61_17735	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
H6S61_17740	COG0456	acetyltransferase
H6S61_17750	COG0835	chemotaxis
H6S61_17750	COG0784	Response regulator, receiver
H6S61_17755	COG1609	Transcriptional regulator
H6S61_17760	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H6S61_17765	COG1879	ABC-type sugar transport system periplasmic component
H6S61_17770	COG1172	Belongs to the binding-protein-dependent transport system permease family
H6S61_17775	COG1129	ABC transporter
H6S61_17780	COG1869	D-ribose catabolic process
H6S61_17795	COG2315	Protein conserved in bacteria
H6S61_17800	COG2425	protein containing a von Willebrand factor type A (vWA) domain
H6S61_17815	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
H6S61_17830	COG1288	antiporter activity
H6S61_17840	COG0671	phosphoesterase, PA-phosphatase related
H6S61_17855	COG2962	Rard protein
H6S61_17880	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
H6S61_17885	COG0814	amino acid
H6S61_17910	COG3174	membrane
H6S61_17915	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H6S61_17945	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H6S61_17950	COG0583	DNA-binding transcription factor activity
H6S61_17960	COG0443	Heat shock 70 kDa protein
H6S61_17965	COG1454	alcohol dehydrogenase
H6S61_17975	COG2133	pyrroloquinoline quinone binding
H6S61_17980	COG1619	proteins homologs of microcin C7 resistance protein MccF
H6S61_17995	COG0247	lactate metabolic process
H6S61_18000	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
H6S61_18025	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
H6S61_18040	COG3059	membrane
H6S61_18045	COG4175	Glycine betaine
H6S61_18065	COG1309	transcriptional regulator
H6S61_18085	COG1686	Belongs to the peptidase S11 family
H6S61_18105	COG1760	l-serine dehydratase
H6S61_18110	COG3104	oligopeptide transport
H6S61_18120	COG0583	DNA-binding transcription factor activity
H6S61_18125	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H6S61_18145	COG3842	ATPase activity
H6S61_18150	COG1840	ABC-type Fe3 transport system, periplasmic component
H6S61_18155	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
H6S61_18160	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
H6S61_18170	COG2207	Transcriptional regulator
H6S61_18170	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H6S61_18175	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H6S61_18200	COG1011	Hydrolase
H6S61_18225	COG1765	OsmC-like protein
H6S61_18230	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H6S61_18230	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H6S61_18235	COG3706	GGDEF domain
H6S61_18250	COG0840	transmembrane signaling receptor activity
H6S61_18270	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
H6S61_18295	COG2084	Dehydrogenase
H6S61_18310	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H6S61_18315	COG0739	heme binding
H6S61_18335	COG3314	Sporulation integral membrane protein YlbJ
H6S61_18350	COG0840	transmembrane signaling receptor activity
H6S61_18360	COG0366	Alpha amylase catalytic
H6S61_18365	COG0589	response to stress
H6S61_18370	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H6S61_18375	COG0784	Response regulator, receiver
H6S61_18375	COG0835	chemotaxis
H6S61_18385	COG0748	coenzyme F420 binding
H6S61_18390	COG3721	Heme iron utilization protein
H6S61_18400	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
H6S61_18405	COG0811	peptide transport
H6S61_18410	COG0848	biopolymer transport protein
H6S61_18420	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H6S61_18425	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
H6S61_18470	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
H6S61_18475	COG0633	Ferredoxin
H6S61_18475	COG0633	Ferredoxin
H6S61_18475	COG3217	Mosc domain protein beta barrel domain protein
H6S61_18475	COG3217	Mosc domain protein beta barrel domain protein
H6S61_18480	COG0418	dihydroorotase activity
H6S61_18490	COG2354	Protein conserved in bacteria
H6S61_18520	COG3833	ABC-type maltose transport systems, permease component
H6S61_18525	COG1175	transmembrane transport
H6S61_18535	COG3842	ATPase activity
H6S61_18540	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H6S61_18550	COG1596	polysaccharide export
H6S61_18555	COG0489	protein tyrosine kinase activity
H6S61_18555	COG3206	protein involved in exopolysaccharide biosynthesis
H6S61_18620	COG0714	Associated with various cellular activities
H6S61_18640	COG2304	oxidoreductase activity
H6S61_18655	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H6S61_18660	COG0581	inorganic phosphate transmembrane transporter activity
H6S61_18665	COG0573	inorganic phosphate transmembrane transporter activity
H6S61_18700	COG0513	Belongs to the DEAD box helicase family
H6S61_18725	COG1388	LysM domain
H6S61_18725	COG1376	ErfK ybiS ycfS ynhG family protein
H6S61_18730	COG0415	Belongs to the DNA photolyase family
H6S61_18735	COG0789	Transcriptional regulator
H6S61_18740	COG3272	Protein of unknown function (DUF1722)
H6S61_18745	COG0813	purine-nucleoside phosphorylase activity
H6S61_18770	COG1566	PFAM secretion protein HlyD family protein
H6S61_18775	COG4720	Psort location CytoplasmicMembrane, score
H6S61_18780	COG1122	ATPase activity
H6S61_18795	COG4946	Tricorn protease homolog
H6S61_18795	COG0793	Belongs to the peptidase S41A family
H6S61_18800	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H6S61_18825	COG0668	transmembrane transport
H6S61_18845	COG1538	Outer membrane efflux protein
H6S61_18855	COG2274	protein secretion by the type I secretion system
H6S61_18865	COG3111	PFAM Bacterial OB fold (BOF) protein
H6S61_18880	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
H6S61_18915	COG3040	lipid binding
H6S61_18975	COG3240	lipase activity
H6S61_18990	COG2211	Major facilitator Superfamily
H6S61_19000	COG0346	lactoylglutathione lyase activity
H6S61_19015	COG0753	catalase activity
H6S61_19035	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
H6S61_19045	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
H6S61_19060	COG0393	Putative heavy-metal-binding
H6S61_19080	COG4771	TonB-dependent receptor
H6S61_19085	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
H6S61_19090	COG0039	L-malate dehydrogenase activity
H6S61_19105	COG2814	Major facilitator Superfamily
H6S61_19175	COG0351	phosphomethylpyrimidine kinase
H6S61_19180	COG0671	phosphoesterase, PA-phosphatase related
H6S61_19195	COG0561	phosphatase activity
H6S61_19205	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H6S61_19210	COG0076	glutamate decarboxylase activity
H6S61_19215	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H6S61_19240	COG4221	oxidoreductase activity
H6S61_19255	COG0745	RESPONSE REGULATOR receiver
H6S61_19260	COG2205	protein histidine kinase activity
H6S61_19265	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
H6S61_19270	COG2194	sulfuric ester hydrolase activity
H6S61_19275	COG1368	sulfuric ester hydrolase activity
H6S61_19290	COG2356	endonuclease I
H6S61_19305	COG3706	GGDEF domain
H6S61_19315	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H6S61_19350	COG2175	clavaminate synthase activity
H6S61_19355	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H6S61_19400	COG1301	dicarboxylic acid transport
H6S61_19410	COG0137	argininosuccinate synthase activity
H6S61_19425	COG0583	DNA-binding transcription factor activity
H6S61_19440	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
H6S61_19475	COG0583	DNA-binding transcription factor activity
H6S61_19480	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
H6S61_19485	COG1482	cell wall glycoprotein biosynthetic process
H6S61_19490	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
H6S61_19495	COG1263	PTS System
H6S61_19495	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H6S61_19500	COG1609	Transcriptional regulator
H6S61_19510	COG3383	formate dehydrogenase (NAD+) activity
H6S61_19525	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H6S61_19525	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H6S61_19525	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H6S61_19530	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H6S61_19545	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H6S61_19550	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H6S61_19560	COG2207	Transcriptional regulator
H6S61_19565	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H6S61_19565	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H6S61_19565	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H6S61_19570	COG1482	cell wall glycoprotein biosynthetic process
H6S61_19595	COG1482	cell wall glycoprotein biosynthetic process
H6S61_19600	COG1929	Belongs to the glycerate kinase type-1 family
H6S61_19605	COG0383	alpha-mannosidase activity
H6S61_19610	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H6S61_19610	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H6S61_19610	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H6S61_19615	COG2188	Transcriptional regulator
H6S61_19620	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
H6S61_19625	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
H6S61_19635	COG2375	cellular response to nickel ion
H6S61_19645	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H6S61_19655	COG2211	Major facilitator Superfamily
H6S61_19675	COG1129	ABC transporter
H6S61_19685	COG1609	Transcriptional regulator
H6S61_19700	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H6S61_19710	COG0564	pseudouridine synthase activity
H6S61_19740	COG1566	PFAM secretion protein HlyD family protein
H6S61_19750	COG0534	Mate efflux family protein
H6S61_19755	COG1472	Belongs to the glycosyl hydrolase 3 family
H6S61_19765	COG4580	involved in the transport of maltose and maltodextrins
H6S61_19780	COG1609	Transcriptional regulator
H6S61_19790	COG4608	Belongs to the ABC transporter superfamily
H6S61_19795	COG0444	Belongs to the ABC transporter superfamily
H6S61_19800	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H6S61_19810	COG0747	negative chemotaxis
H6S61_19820	COG1609	Transcriptional regulator
H6S61_19830	COG2723	6-phospho-beta-galactosidase activity
H6S61_19835	COG0395	ABC-type sugar transport system, permease component
H6S61_19850	COG1609	Transcriptional regulator
H6S61_19860	COG2199	diguanylate cyclase activity
H6S61_19870	COG0642	Histidine kinase
H6S61_19880	COG0583	DNA-binding transcription factor activity
H6S61_19890	COG0612	Peptidase, M16
H6S61_19895	COG1283	sodium-dependent phosphate transmembrane transporter activity
H6S61_19905	COG0625	glutathione transferase activity
H6S61_19910	COG1012	belongs to the aldehyde dehydrogenase family
H6S61_19960	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H6S61_19965	COG0840	transmembrane signaling receptor activity
H6S61_19970	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
H6S61_19975	COG1640	4-alpha-glucanotransferase
H6S61_19980	COG0058	SHG alpha-glucan phosphorylase activity
H6S61_19985	COG2909	trisaccharide binding
H6S61_20010	COG3842	ATPase activity
H6S61_20020	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H6S61_20030	COG2182	Extracellular solute-binding protein
H6S61_20035	COG1175	transmembrane transport
H6S61_20040	COG3833	ABC-type maltose transport systems, permease component
H6S61_20070	COG1999	signal sequence binding
H6S61_20075	COG2847	Copper chaperone PCu(A)C
H6S61_20080	COG1162	GTPase activity
H6S61_20085	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
H6S61_20095	COG0531	amino acid
H6S61_20100	COG1982	Orn Lys Arg decarboxylase major
H6S61_20150	COG3706	GGDEF domain
H6S61_20155	COG5001	Diguanylate cyclase
H6S61_20165	COG1741	Belongs to the pirin family
H6S61_20170	COG3123	guanosine phosphorylase activity
H6S61_20190	COG1309	transcriptional regulator
H6S61_20210	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
H6S61_20215	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H6S61_20220	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
H6S61_20260	COG0363	glucosamine-6-phosphate deaminase activity
H6S61_20265	COG3344	reverse transcriptase
H6S61_20275	COG0786	glutamate:sodium symporter activity
H6S61_20280	COG0786	glutamate:sodium symporter activity
H6S61_20300	COG3275	phosphorelay sensor kinase activity
H6S61_20320	COG1136	(ABC) transporter
H6S61_20335	COG0217	transcriptional regulatory protein
H6S61_20355	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
H6S61_20355	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H6S61_20365	COG0444	Belongs to the ABC transporter superfamily
H6S61_20370	COG4608	Belongs to the ABC transporter superfamily
H6S61_20395	COG1444	tRNA N-acetyltransferase activity
H6S61_20405	COG0745	RESPONSE REGULATOR receiver
H6S61_20420	COG0835	chemotaxis
H6S61_20425	COG0840	transmembrane signaling receptor activity
H6S61_20430	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
H6S61_20435	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
H6S61_20440	COG2201	protein-glutamate methylesterase activity
H6S61_20445	COG0840	transmembrane signaling receptor activity
H6S61_20490	COG0406	alpha-ribazole phosphatase activity
H6S61_20510	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
H6S61_20515	COG1737	Transcriptional regulator
H6S61_20520	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H6S61_20520	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
H6S61_20530	COG0110	maltose O-acetyltransferase activity
H6S61_20535	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
H6S61_20540	COG0459	protein refolding
H6S61_20555	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
H6S61_20560	COG3069	C4-dicarboxylate transmembrane transporter activity
H6S61_20590	COG2204	response regulator
H6S61_20600	COG0259	pyridoxamine-phosphate oxidase activity
H6S61_20625	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H6S61_20650	COG5492	domain, Protein
H6S61_20655	COG3119	arylsulfatase activity
H6S61_20660	COG3119	arylsulfatase activity
H6S61_20665	COG0641	radical SAM
H6S61_20670	COG3119	arylsulfatase activity
H6S61_20680	COG0747	negative chemotaxis
H6S61_20685	COG0601	transmembrane transport
H6S61_20690	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H6S61_20720	COG0659	secondary active sulfate transmembrane transporter activity
H6S61_20725	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H6S61_20735	COG1028	Short-chain dehydrogenase reductase Sdr
H6S61_20745	COG5426	von Willebrand factor, type A
H6S61_20750	COG5492	domain, Protein
H6S61_20755	COG1132	(ABC) transporter
H6S61_20770	COG3623	hexulose-6-phosphate isomerase
H6S61_20775	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
H6S61_20780	COG0561	phosphatase activity
H6S61_20810	COG1902	pentaerythritol trinitrate reductase activity
H6S61_20820	COG2814	Major facilitator Superfamily
H6S61_20825	COG1028	Short-chain dehydrogenase reductase Sdr
H6S61_20840	COG0800	Aldolase
H6S61_20845	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H6S61_20850	COG1904	glucuronate isomerase
H6S61_20855	COG0246	Mannitol dehydrogenase
H6S61_20865	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
H6S61_20875	COG2186	Transcriptional regulator
H6S61_20885	COG0513	Belongs to the DEAD box helicase family
H6S61_20905	COG4115	mRNA cleavage
H6S61_20910	COG2258	MOSC domain
H6S61_20940	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
H6S61_20955	COG0840	transmembrane signaling receptor activity
H6S61_20975	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H6S61_20980	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H6S61_21030	COG2015	COG2015, Alkyl sulfatase and related hydrolases
H6S61_21045	COG1349	DNA-binding transcription factor activity
H6S61_21050	COG1349	DNA-binding transcription factor activity
H6S61_21060	COG2222	sugar isomerase
H6S61_21065	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H6S61_21075	COG3716	PTS system mannose fructose sorbose family IID component
H6S61_21080	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
H6S61_21110	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
H6S61_21115	COG1120	ATPase activity
H6S61_21145	COG1136	(ABC) transporter
H6S61_21145	COG0577	efflux transmembrane transporter activity
H6S61_21150	COG0577	efflux transmembrane transporter activity
H6S61_21150	COG1136	(ABC) transporter
H6S61_21155	COG2176	DNA-directed DNA polymerase activity
H6S61_21215	COG2205	protein histidine kinase activity
H6S61_21230	COG2015	COG2015, Alkyl sulfatase and related hydrolases
H6S61_21260	COG0579	oxidoreductase
H6S61_21270	COG3437	response regulator, receiver
H6S61_21290	COG1357	PFAM Pentapeptide repeats (8 copies)
H6S61_21300	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H6S61_21335	COG0513	Belongs to the DEAD box helicase family
H6S61_21355	COG0583	DNA-binding transcription factor activity
H6S61_21365	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H6S61_21395	COG2814	Major facilitator Superfamily
H6S61_21400	COG2207	Transcriptional regulator
H6S61_21415	COG1858	cytochrome C peroxidase
H6S61_21440	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
H6S61_21445	COG0454	-acetyltransferase
H6S61_21460	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H6S61_21460	COG1263	PTS System
H6S61_21475	COG3046	protein related to deoxyribodipyrimidine photolyase
H6S61_21480	COG2207	Transcriptional regulator
H6S61_21485	COG1881	PFAM PEBP family protein
H6S61_21490	COG0494	nUDIX hydrolase
H6S61_21520	COG0668	transmembrane transport
H6S61_21560	COG1028	Short-chain dehydrogenase reductase Sdr
H6S61_21570	COG1917	Cupin 2, conserved barrel domain protein
H6S61_21585	COG2207	Transcriptional regulator
H6S61_21590	COG1028	Short-chain dehydrogenase reductase Sdr
H6S61_21595	COG0697	spore germination
H6S61_21600	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H6S61_21605	COG0800	Aldolase
H6S61_21610	COG0366	Alpha amylase catalytic
H6S61_21620	COG3366	ferrous iron transmembrane transporter activity
H6S61_21625	COG0700	Nucleoside recognition
H6S61_21630	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H6S61_21680	COG2194	sulfuric ester hydrolase activity
H6S61_21685	COG0583	DNA-binding transcription factor activity
H6S61_21695	COG2015	COG2015, Alkyl sulfatase and related hydrolases
H6S61_21720	COG0673	inositol 2-dehydrogenase activity
H6S61_21725	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
H6S61_21730	COG2197	response regulator
H6S61_21735	COG0384	phenazine biosynthesis protein PhzF
H6S61_21745	COG0625	glutathione transferase activity
H6S61_21750	COG1879	ABC-type sugar transport system periplasmic component
H6S61_21760	COG3284	Transcriptional regulator
H6S61_21765	COG1012	belongs to the aldehyde dehydrogenase family
H6S61_21775	COG1253	flavin adenine dinucleotide binding
H6S61_21785	COG0242	peptide deformylase activity
H6S61_21800	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H6S61_21805	COG1609	Transcriptional regulator
H6S61_21820	COG0488	(ABC) transporter
H6S61_21825	COG0814	amino acid
H6S61_21830	COG3033	Beta-eliminating lyase
H6S61_21845	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H6S61_21870	COG4067	protein conserved in archaea
H6S61_21870	COG0189	ligase activity
H6S61_21875	COG0189	ligase activity
H6S61_21885	COG4774	siderophore transport
H6S61_21885	COG1629	transport
H6S61_21890	COG4607	ABC-type enterochelin transport system periplasmic component
H6S61_21900	COG1021	2,3-dihydroxybenzoate-AMP ligase
H6S61_21920	COG1021	2,3-dihydroxybenzoate-AMP ligase
H6S61_21925	COG1169	isochorismate synthase
H6S61_21930	COG1028	Short-chain dehydrogenase reductase Sdr
H6S61_21935	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H6S61_21950	COG2977	Belongs to the P-Pant transferase superfamily
H6S61_21965	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H6S61_21970	COG0840	transmembrane signaling receptor activity
H6S61_21980	COG2755	lipolytic protein G-D-S-L family
H6S61_21985	COG5002	protein histidine kinase activity
H6S61_21985	COG5001	Diguanylate cyclase
H6S61_22000	COG4160	amino acid transport
H6S61_22005	COG4215	(ABC) transporter
H6S61_22010	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H6S61_22015	COG1126	abc transporter atp-binding protein
H6S61_22020	COG3015	lipoprotein NlpE involved in copper resistance
H6S61_22035	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H6S61_22075	COG2814	Major facilitator Superfamily
H6S61_22100	COG1139	Iron-sulfur cluster binding protein
H6S61_22110	COG1620	l-lactate permease
H6S61_22115	COG0583	DNA-binding transcription factor activity
H6S61_22120	COG1505	serine-type exopeptidase activity
H6S61_22125	COG4172	Belongs to the ABC transporter superfamily
H6S61_22135	COG1067	ATP-dependent peptidase activity
H6S61_22140	COG0402	S-adenosylhomocysteine deaminase activity
H6S61_22145	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
H6S61_22155	COG2239	Acts as a magnesium transporter
H6S61_22180	COG0745	RESPONSE REGULATOR receiver
H6S61_22185	COG2205	protein histidine kinase activity
H6S61_22200	COG0121	glutamine amidotransferase
H6S61_22205	COG0531	amino acid
H6S61_22210	COG1522	sequence-specific DNA binding
H6S61_22230	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
H6S61_22235	COG0583	DNA-binding transcription factor activity
H6S61_22260	COG2205	protein histidine kinase activity
H6S61_22260	COG5002	protein histidine kinase activity
H6S61_22260	COG0784	Response regulator, receiver
H6S61_22270	COG2926	Belongs to the UPF0265 family
H6S61_22280	COG3132	Protein of unknown function, DUF480
H6S61_22285	COG2827	Endonuclease containing a URI domain
H6S61_22335	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H6S61_22340	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H6S61_22350	COG0183	Belongs to the thiolase family
H6S61_22370	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
H6S61_22375	COG1940	carbohydrate kinase activity
H6S61_22380	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
H6S61_22385	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
H6S61_22390	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
H6S61_22395	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
H6S61_22400	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H6S61_22405	COG1737	Transcriptional regulator
H6S61_22410	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
H6S61_22415	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
H6S61_22425	COG3005	denitrification pathway
H6S61_22435	COG0243	molybdopterin cofactor binding
H6S61_22445	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H6S61_22450	COG3850	Histidine kinase
H6S61_22455	COG2197	response regulator
H6S61_22475	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
H6S61_22475	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
H6S61_22485	COG0516	GMP reductase activity
H6S61_22495	COG2204	response regulator
H6S61_22505	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
H6S61_22510	COG0732	type I restriction modification DNA specificity domain
H6S61_22530	COG0714	Associated with various cellular activities
H6S61_22535	COG2425	protein containing a von Willebrand factor type A (vWA) domain
H6S61_22555	COG1538	Outer membrane efflux protein
H6S61_22560	COG1566	PFAM secretion protein HlyD family protein
H6S61_22605	COG0183	Belongs to the thiolase family
H6S61_22615	COG0427	acetyl-CoA hydrolase
H6S61_22635	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H6S61_22655	COG3568	Endonuclease Exonuclease Phosphatase
H6S61_22680	COG0513	Belongs to the DEAD box helicase family
H6S61_22695	COG1846	Transcriptional regulator
H6S61_22720	COG0842	Transport permease protein
H6S61_22725	COG1131	(ABC) transporter
H6S61_22735	COG0837	glucose binding
H6S61_22735	COG1737	Transcriptional regulator
H6S61_22745	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
H6S61_22755	COG4145	pantothenate transmembrane transporter activity
H6S61_22770	COG0251	oxidation-reduction process
H6S61_22775	COG4251	negative regulation of phosphorylation
H6S61_22775	COG2203	Gaf domain
H6S61_22775	COG5001	Diguanylate cyclase
H6S61_22775	COG3706	GGDEF domain
H6S61_22780	COG0583	DNA-binding transcription factor activity
H6S61_22785	COG2814	Major facilitator Superfamily
H6S61_22800	COG0697	spore germination
H6S61_22815	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H6S61_22825	COG1764	response to oxidative stress
H6S61_22830	COG1846	Transcriptional regulator
H6S61_22855	COG1280	lysine exporter protein (LysE YggA)
H6S61_22865	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H6S61_22870	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
H6S61_22875	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H6S61_22880	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
H6S61_22905	COG1612	heme a metabolic process
H6S61_22910	COG0109	protoheme IX farnesyltransferase activity
H6S61_22920	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H6S61_22925	COG0840	transmembrane signaling receptor activity
H6S61_22945	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H6S61_22965	COG2897	thiosulfate sulfurtransferase activity
H6S61_22975	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
H6S61_22980	COG0303	'Molybdopterin
H6S61_22985	COG0302	gtp cyclohydrolase
H6S61_22995	COG0038	chloride channel
H6S61_23000	COG3344	reverse transcriptase