locus-tag	class	description
FORC16_0002	COG0592	DNA-directed DNA polymerase activity
FORC16_0004	COG0187	DNA topoisomerase II activity
FORC16_0005	COG0071	Belongs to the small heat shock protein (HSP20) family
FORC16_0007	COG3977	Valine--pyruvate aminotransferase
FORC16_0009	COG0751	glycine-tRNA ligase activity
FORC16_0011	COG2119	membrane
FORC16_0016	COG0604	alcohol dehydrogenase
FORC16_0017	COG0183	Belongs to the thiolase family
FORC16_0019	COG1739	Uncharacterized protein family UPF0029
FORC16_0020	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FORC16_0022	COG3335	DDE superfamily endonuclease
FORC16_0024	COG2132	Multicopper oxidase
FORC16_0029	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
FORC16_0033	COG0006	proline dipeptidase activity
FORC16_0033	COG0006	proline dipeptidase activity
FORC16_0041	COG0210	DNA helicase
FORC16_0042	COG1280	lysine exporter protein (LysE YggA)
FORC16_0044	COG2962	Rard protein
FORC16_0045	COG0514	ATP-dependent DNA helicase (RecQ)
FORC16_0047	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
FORC16_0050	COG3118	belongs to the thioredoxin family
FORC16_0051	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
FORC16_0053	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
FORC16_0056	COG3335	DDE superfamily endonuclease
FORC16_0064	COG1322	Protein conserved in bacteria
FORC16_0066	COG3165	ubiquinone biosynthetic process from chorismate
FORC16_0068	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FORC16_0070	COG0805	protein transport
FORC16_0071	COG0084	hydrolase, TatD family'
FORC16_0073	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FORC16_0073	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FORC16_0077	COG3078	GTPase activator activity
FORC16_0079	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FORC16_0080	COG3300	MHYT domain
FORC16_0080	COG5001	Diguanylate cyclase
FORC16_0081	COG2204	response regulator
FORC16_0082	COG3852	Histidine kinase
FORC16_0084	COG0174	glutamine synthetase
FORC16_0088	COG1295	ribonuclease BN
FORC16_0090	COG0456	acetyltransferase
FORC16_0094	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
FORC16_0095	COG3031	protein transport across the cell outer membrane
FORC16_0097	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
FORC16_0098	COG1459	type II secretion system
FORC16_0099	COG2165	general secretion pathway protein
FORC16_0100	COG2165	general secretion pathway protein
FORC16_0101	COG2165	general secretion pathway protein
FORC16_0102	COG4795	General secretion pathway protein
FORC16_0103	COG3156	type II secretion system protein K
FORC16_0104	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
FORC16_0105	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
FORC16_0107	COG1218	3'(2'),5'-bisphosphate nucleotidase
FORC16_0108	COG0494	nUDIX hydrolase
FORC16_0110	COG1040	competence protein
FORC16_0113	COG2183	response to ionizing radiation
FORC16_0115	COG0745	RESPONSE REGULATOR receiver
FORC16_0117	COG2233	PERMEase
FORC16_0118	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
FORC16_0119	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FORC16_0120	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FORC16_0125	COG0848	biopolymer transport protein
FORC16_0126	COG0811	peptide transport
FORC16_0127	COG0811	peptide transport
FORC16_0129	COG4206	TonB-dependent receptor
FORC16_0130	COG4174	ABC transporter (Permease)
FORC16_0131	COG4239	(ABC) transporter, permease
FORC16_0132	COG0747	negative chemotaxis
FORC16_0133	COG0444	Belongs to the ABC transporter superfamily
FORC16_0134	COG4608	Belongs to the ABC transporter superfamily
FORC16_0139	COG1561	YicC-like family, N-terminal region
FORC16_0142	COG1560	Kdo2-lipid A biosynthetic process
FORC16_0146	COG2003	Belongs to the UPF0758 family
FORC16_0149	COG2194	sulfuric ester hydrolase activity
FORC16_0151	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
FORC16_0153	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
FORC16_0156	COG0463	Glycosyl transferase, family 2
FORC16_0157	COG0859	PFAM glycosyl transferase family 9
FORC16_0158	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
FORC16_0159	COG3642	lipopolysaccharide core region biosynthetic process
FORC16_0161	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
FORC16_0166	COG2895	sulfate adenylyltransferase (ATP) activity
FORC16_0167	COG0529	Catalyzes the synthesis of activated sulfate
FORC16_0168	COG0175	sulfate reduction
FORC16_0169	COG3273	potassium ion transport
FORC16_0169	COG0471	metal ion transport
FORC16_0170	COG1519	Transferase
FORC16_0171	COG0859	PFAM glycosyl transferase family 9
FORC16_0173	COG1560	Kdo2-lipid A biosynthetic process
FORC16_0175	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FORC16_0182	COG1596	polysaccharide export
FORC16_0193	COG1215	transferase activity, transferring glycosyl groups
FORC16_0196	COG1482	cell wall glycoprotein biosynthetic process
FORC16_0197	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FORC16_0201	COG3064	Membrane
FORC16_0224	COG0201	protein transport
FORC16_0227	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
FORC16_0233	COG0545	Peptidyl-prolyl cis-trans isomerase
FORC16_0234	COG3266	domain, Protein
FORC16_0234	COG3061	Opacity-associated protein A
FORC16_0236	COG2153	protein acetylation
FORC16_0238	COG0737	Belongs to the 5'-nucleotidase family
FORC16_0239	COG1648	precorrin-2 dehydrogenase activity
FORC16_0239	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
FORC16_0241	COG2895	sulfate adenylyltransferase (ATP) activity
FORC16_0242	COG0471	metal ion transport
FORC16_0242	COG3273	potassium ion transport
FORC16_0247	COG1136	(ABC) transporter
FORC16_0247	COG0577	efflux transmembrane transporter activity
FORC16_0251	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
FORC16_0254	COG0729	surface antigen
FORC16_0255	COG2911	Protein conserved in bacteria
FORC16_0256	COG2105	PFAM AIG2 family protein
FORC16_0261	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FORC16_0262	COG0163	prenyltransferase activity
FORC16_0263	COG4143	(ABC) transporter
FORC16_0264	COG1178	ABC-type Fe3 transport system permease component
FORC16_0266	COG3028	Belongs to the UPF0307 family
FORC16_0267	COG0312	modulator of DNA gyrase
FORC16_0268	COG2239	Acts as a magnesium transporter
FORC16_0269	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
FORC16_0270	COG1660	Displays ATPase and GTPase activities
FORC16_0271	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FORC16_0272	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
FORC16_0274	COG1137	ATPase activity
FORC16_0275	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
FORC16_0277	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
FORC16_0278	COG0517	IMP dehydrogenase activity
FORC16_0278	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
FORC16_0280	COG1127	ABC transporter
FORC16_0281	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
FORC16_0282	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
FORC16_0283	COG2854	intermembrane phospholipid transfer
FORC16_0285	COG5007	Belongs to the BolA IbaG family
FORC16_0287	COG0204	Acyl-transferase
FORC16_0288	COG0589	response to stress
FORC16_0292	COG0039	L-malate dehydrogenase activity
FORC16_0293	COG0142	geranyltranstransferase activity
FORC16_0294	COG0261	This protein binds to 23S rRNA in the presence of protein L20
FORC16_0297	COG2966	Psort location CytoplasmicMembrane, score
FORC16_0298	COG3610	response to peptide
FORC16_0303	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
FORC16_0308	COG0066	3-isopropylmalate dehydratase activity
FORC16_0310	COG0473	3-isopropylmalate dehydrogenase activity
FORC16_0316	COG1022	Amp-dependent synthetase and ligase
FORC16_0317	COG0028	Belongs to the TPP enzyme family
FORC16_0318	COG0440	acetolactate synthase activity
FORC16_0319	COG3706	GGDEF domain
FORC16_0321	COG0469	pyruvate kinase activity
FORC16_0322	COG1349	DNA-binding transcription factor activity
FORC16_0324	COG3722	fumarate hydratase activity
FORC16_0325	COG0246	Mannitol dehydrogenase
FORC16_0326	COG2213	PTS system mannitol-specific
FORC16_0326	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
FORC16_0327	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
FORC16_0349	COG3550	peptidyl-serine autophosphorylation
FORC16_0351	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FORC16_0353	COG1610	YqeY-like protein
FORC16_0354	COG0828	Belongs to the bacterial ribosomal protein bS21 family
FORC16_0357	COG0596	Alpha beta hydrolase
FORC16_0359	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
FORC16_0360	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
FORC16_0362	COG0617	tRNA 3'-terminal CCA addition
FORC16_0363	COG3409	Peptidoglycan-binding domain 1 protein
FORC16_0363	COG3267	Type II secretory pathway component ExeA
FORC16_0364	COG4991	sh3 domain protein
FORC16_0365	COG0306	phosphate transporter
FORC16_0366	COG1392	Phosphate transport regulator
FORC16_0367	COG3025	triphosphatase activity
FORC16_0368	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
FORC16_0370	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
FORC16_0372	COG1538	Outer membrane efflux protein
FORC16_0373	COG0494	nUDIX hydrolase
FORC16_0374	COG3151	Protein conserved in bacteria
FORC16_0376	COG3150	esterase
FORC16_0377	COG0187	DNA topoisomerase II activity
FORC16_0379	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FORC16_0380	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FORC16_0381	COG3105	Protein conserved in bacteria
FORC16_0382	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
FORC16_0385	COG0723	plastoquinol--plastocyanin reductase activity
FORC16_0386	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
FORC16_0387	COG2857	Cytochrome c1
FORC16_0388	COG0625	glutathione transferase activity
FORC16_0389	COG2969	positive regulation of protein catabolic process
FORC16_0390	COG2823	Periplasmic or secreted lipoprotein
FORC16_0391	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
FORC16_0393	COG3107	peptidoglycan biosynthetic process
FORC16_0394	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
FORC16_0396	COG3116	cell division
FORC16_0397	COG0768	penicillin binding
FORC16_0399	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
FORC16_0401	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
FORC16_0402	COG0772	Belongs to the SEDS family
FORC16_0404	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FORC16_0405	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
FORC16_0406	COG0849	cell division
FORC16_0407	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
FORC16_0410	COG0653	protein targeting
FORC16_0411	COG0494	nUDIX hydrolase
FORC16_0413	COG0505	Belongs to the CarA family
FORC16_0417	COG0730	response to heat
FORC16_0418	COG0583	DNA-binding transcription factor activity
FORC16_0419	COG2860	membrane
FORC16_0420	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
FORC16_0422	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
FORC16_0424	COG0493	'glutamate synthase
FORC16_0425	COG0069	glutamate synthase activity
FORC16_0425	COG0070	glutamate synthase
FORC16_0425	COG0067	glutamate synthase
FORC16_0427	COG0067	glutamate synthase
FORC16_0427	COG0070	glutamate synthase
FORC16_0427	COG0069	glutamate synthase activity
FORC16_0428	COG1242	4 iron, 4 sulfur cluster binding
FORC16_0429	COG2203	Gaf domain
FORC16_0429	COG3706	GGDEF domain
FORC16_0429	COG4251	negative regulation of phosphorylation
FORC16_0429	COG5001	Diguanylate cyclase
FORC16_0430	COG0784	Response regulator, receiver
FORC16_0430	COG5002	protein histidine kinase activity
FORC16_0430	COG2198	Histidine kinase
FORC16_0432	COG0745	RESPONSE REGULATOR receiver
FORC16_0438	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
FORC16_0444	COG1115	amino acid carrier protein
FORC16_0445	COG3022	response to hydroperoxide
FORC16_0446	COG0513	Belongs to the DEAD box helicase family
FORC16_0447	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
FORC16_0450	COG0716	FMN binding
FORC16_0452	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FORC16_0453	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
FORC16_0454	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
FORC16_0455	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
FORC16_0458	COG0667	Aldo Keto reductase
FORC16_0463	COG0730	response to heat
FORC16_0470	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
FORC16_0473	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
FORC16_0474	COG0732	type I restriction modification DNA specificity domain
FORC16_0475	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
FORC16_0476	COG1106	Psort location Cytoplasmic, score
FORC16_0482	COG3293	Transposase
FORC16_0485	COG1283	sodium-dependent phosphate transmembrane transporter activity
FORC16_0486	COG0583	DNA-binding transcription factor activity
FORC16_0487	COG0640	Transcriptional regulator
FORC16_0489	COG0728	peptidoglycan biosynthetic process
FORC16_0490	COG0196	riboflavin kinase activity
FORC16_0491	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
FORC16_0493	COG1047	Peptidyl-prolyl cis-trans
FORC16_0496	COG3275	phosphorelay sensor kinase activity
FORC16_0497	COG1966	Carbon starvation protein
FORC16_0500	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
FORC16_0501	COG1472	Belongs to the glycosyl hydrolase 3 family
FORC16_0502	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
FORC16_0503	COG1605	Chorismate mutase
FORC16_0503	COG0287	Prephenate dehydrogenase
FORC16_0504	COG0739	heme binding
FORC16_0506	COG0488	(ABC) transporter
FORC16_0509	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
FORC16_0510	COG1605	Chorismate mutase
FORC16_0510	COG0077	Prephenate dehydratase
FORC16_0511	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
FORC16_0512	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FORC16_0517	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
FORC16_0520	COG0745	RESPONSE REGULATOR receiver
FORC16_0521	COG5002	protein histidine kinase activity
FORC16_0523	COG0248	Ppx GppA phosphatase
FORC16_0525	COG0573	inorganic phosphate transmembrane transporter activity
FORC16_0526	COG0581	inorganic phosphate transmembrane transporter activity
FORC16_0528	COG0704	Plays a role in the regulation of phosphate uptake
FORC16_0533	COG0450	alkyl hydroperoxide reductase
FORC16_0534	COG0583	DNA-binding transcription factor activity
FORC16_0535	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
FORC16_0537	COG0517	IMP dehydrogenase activity
FORC16_0540	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
FORC16_0542	COG1862	Preprotein translocase
FORC16_0543	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FORC16_0544	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FORC16_0547	COG0483	inositol monophosphate 1-phosphatase activity
FORC16_0548	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
FORC16_0551	COG0822	iron-sulfur transferase activity
FORC16_0554	COG0443	Heat shock 70 kDa protein
FORC16_0555	COG0633	Ferredoxin
FORC16_0556	COG2975	iron-sulfur cluster assembly
FORC16_0559	COG0820	rRNA (adenine-C2-)-methyltransferase activity
FORC16_0563	COG2976	Protein conserved in bacteria
FORC16_0564	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FORC16_0567	COG2203	Gaf domain
FORC16_0567	COG2199	diguanylate cyclase activity
FORC16_0570	COG0517	IMP dehydrogenase activity
FORC16_0570	COG0516	GMP reductase activity
FORC16_0571	COG0519	Catalyzes the synthesis of GMP from XMP
FORC16_0571	COG0518	GMP synthase (glutamine-hydrolyzing) activity
FORC16_0573	COG1584	GPR1 FUN34 yaaH family protein
FORC16_0574	COG1115	amino acid carrier protein
FORC16_0575	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FORC16_0576	COG0583	DNA-binding transcription factor activity
FORC16_0579	COG0009	L-threonylcarbamoyladenylate synthase
FORC16_0587	COG2867	negative regulation of translational initiation
FORC16_0589	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FORC16_0590	COG0497	DNA recombination
FORC16_0591	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
FORC16_0592	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
FORC16_0605	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
FORC16_0606	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
FORC16_0607	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
FORC16_0608	COG0583	DNA-binding transcription factor activity
FORC16_0609	COG0590	tRNA wobble adenosine to inosine editing
FORC16_0616	COG2195	Cleaves the N-terminal amino acid of tripeptides
FORC16_0617	COG2252	PERMEase
FORC16_0623	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
FORC16_0624	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FORC16_0624	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FORC16_0629	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
FORC16_0630	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
FORC16_0631	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
FORC16_0632	COG0142	geranyltranstransferase activity
FORC16_0634	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
FORC16_0639	COG0583	DNA-binding transcription factor activity
FORC16_0641	COG2363	Small membrane protein
FORC16_0644	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FORC16_0645	COG1611	Belongs to the LOG family
FORC16_0646	COG3706	GGDEF domain
FORC16_0650	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
FORC16_0651	COG1464	Belongs to the NlpA lipoprotein family
FORC16_0652	COG2011	ABC-type metal ion transport system permease component
FORC16_0653	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
FORC16_0654	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
FORC16_0656	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FORC16_0656	COG1263	PTS System
FORC16_0657	COG0366	Alpha amylase catalytic
FORC16_0664	COG1686	Belongs to the peptidase S11 family
FORC16_0665	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
FORC16_0666	COG0772	Belongs to the SEDS family
FORC16_0667	COG0768	penicillin binding
FORC16_0669	COG0799	negative regulation of ribosome biogenesis
FORC16_0670	COG1466	dna polymerase III delta subunit
FORC16_0671	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
FORC16_0673	COG2888	peptidyl-tyrosine sulfation
FORC16_0674	COG0815	Transfers the fatty acyl group on membrane lipoproteins
FORC16_0675	COG4535	Mg2 and Co2 transporter CorC
FORC16_0676	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
FORC16_0677	COG1702	phosphate starvation-inducible protein PhoH
FORC16_0678	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FORC16_0679	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FORC16_0685	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
FORC16_0687	COG2890	protein-(glutamine-N5) methyltransferase activity
FORC16_0688	COG3094	Invasion gene expression up-regulator, SirB
FORC16_0689	COG2912	Transglutaminase-like superfamily
FORC16_0693	COG1187	pseudouridine synthase activity
FORC16_0694	COG2840	Smr protein MutS2
FORC16_0695	COG3735	TraB family
FORC16_0698	COG2217	Heavy metal translocating P-type atpase
FORC16_0698	COG2608	mercury ion transmembrane transporter activity
FORC16_0710	COG0784	Response regulator, receiver
FORC16_0710	COG0835	chemotaxis
FORC16_0711	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
FORC16_0712	COG1815	bacterial-type flagellum-dependent cell motility
FORC16_0713	COG1558	bacterial-type flagellum-dependent cell motility
FORC16_0714	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
FORC16_0715	COG1749	Flagellar hook protein flgE
FORC16_0716	COG4787	bacterial-type flagellum-dependent cell motility
FORC16_0717	COG4786	Flagellar basal body rod
FORC16_0718	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
FORC16_0720	COG3951	Flagellar rod assembly protein muramidase FlgJ
FORC16_0720	COG1705	Flagellar rod assembly protein muramidase FlgJ
FORC16_0722	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FORC16_0723	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FORC16_0726	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FORC16_0727	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FORC16_0728	COG2190	(PTS) system
FORC16_0729	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FORC16_0730	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
FORC16_0731	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
FORC16_0732	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
FORC16_0738	COG0330	HflC and HflK could
FORC16_0739	COG3118	belongs to the thioredoxin family
FORC16_0740	COG0300	oxidoreductase activity
FORC16_0741	COG1090	epimerase
FORC16_0746	COG0622	Phosphoesterase
FORC16_0750	COG3710	Transcriptional regulator
FORC16_0751	COG0326	Molecular chaperone. Has ATPase activity
FORC16_0753	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
FORC16_0755	COG3104	oligopeptide transport
FORC16_0757	COG0367	asparagine synthase
FORC16_0758	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
FORC16_0758	COG4651	solute:proton antiporter activity
FORC16_0759	COG1940	carbohydrate kinase activity
FORC16_0759	COG1846	Transcriptional regulator
FORC16_0760	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
FORC16_0761	COG2190	(PTS) system
FORC16_0761	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FORC16_0761	COG1263	PTS System
FORC16_0762	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FORC16_0765	COG0716	FMN binding
FORC16_0767	COG0596	Alpha beta hydrolase
FORC16_0769	COG0033	Phosphoglucomutase
FORC16_0770	COG2964	Protein conserved in bacteria
FORC16_0771	COG0251	oxidation-reduction process
FORC16_0773	COG0446	pyridine nucleotide-disulphide oxidoreductase
FORC16_0775	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
FORC16_0777	COG2009	succinate dehydrogenase
FORC16_0778	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
FORC16_0779	COG1053	succinate dehydrogenase
FORC16_0781	COG0567	Dehydrogenase, E1 component
FORC16_0782	COG0508	dehydrogenase complex catalyzes the overall conversion of
FORC16_0785	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FORC16_0787	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
FORC16_0789	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
FORC16_0793	COG3102	Protein conserved in bacteria
FORC16_0794	COG0788	formyltetrahydrofolate deformylase activity
FORC16_0796	COG1199	ATP-dependent helicase activity
FORC16_0797	COG1214	PFAM Peptidase M22, glycoprotease
FORC16_0800	COG0596	Alpha beta hydrolase
FORC16_0801	COG0318	PFAM AMP-dependent synthetase and ligase
FORC16_0804	COG2894	cell division
FORC16_0807	COG2951	lytic endotransglycosylase activity
FORC16_0809	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
FORC16_0812	COG0745	RESPONSE REGULATOR receiver
FORC16_0813	COG5002	protein histidine kinase activity
FORC16_0815	COG1028	Short-chain dehydrogenase reductase Sdr
FORC16_0817	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FORC16_0822	COG2986	histidine ammonia-lyase
FORC16_0823	COG1216	Glycosyl transferase, family 2
FORC16_0825	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FORC16_0827	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FORC16_0828	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FORC16_0837	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
FORC16_0839	COG0745	RESPONSE REGULATOR receiver
FORC16_0844	COG3842	ATPase activity
FORC16_0845	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
FORC16_0846	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
FORC16_0847	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
FORC16_0849	COG2204	response regulator
FORC16_0850	COG4191	Histidine kinase
FORC16_0855	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
FORC16_0856	COG0776	regulation of translation
FORC16_0857	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FORC16_0858	COG1555	photosystem II stabilization
FORC16_0862	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
FORC16_0863	COG0436	Aminotransferase
FORC16_0864	COG1169	isochorismate synthase
FORC16_0866	COG0596	Alpha beta hydrolase
FORC16_0867	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
FORC16_0868	COG1441	menaquinone biosynthetic process
FORC16_0869	COG0318	PFAM AMP-dependent synthetase and ligase
FORC16_0876	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FORC16_0877	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FORC16_0880	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
FORC16_0881	COG1522	sequence-specific DNA binding
FORC16_0883	COG1946	Acyl-CoA thioesterase
FORC16_0884	COG3126	Type III secretion system lipoprotein chaperone (YscW)
FORC16_0893	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
FORC16_0896	COG3139	Protein of unknown function (DUF1315)
FORC16_0897	COG0252	asparaginase activity
FORC16_0898	COG0616	signal peptide processing
FORC16_0899	COG0446	pyridine nucleotide-disulphide oxidoreductase
FORC16_0899	COG1902	pentaerythritol trinitrate reductase activity
FORC16_0900	COG0778	Nitroreductase
FORC16_0901	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FORC16_0902	COG0123	including yeast histone deacetylase and acetoin utilization protein
FORC16_0904	COG3706	GGDEF domain
FORC16_0904	COG0745	RESPONSE REGULATOR receiver
FORC16_0905	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FORC16_0906	COG2731	YhcH YjgK YiaL family protein
FORC16_0907	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FORC16_0908	COG0569	domain protein
FORC16_0909	COG3083	sulfuric ester hydrolase activity
FORC16_0911	COG3081	Nucleoid-associated protein
FORC16_0914	COG1757	Na H antiporter
FORC16_0915	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
FORC16_0917	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FORC16_0918	COG2095	MarC family integral membrane protein
FORC16_0919	COG1012	belongs to the aldehyde dehydrogenase family
FORC16_0919	COG1454	alcohol dehydrogenase
FORC16_0921	COG1028	Short-chain dehydrogenase reductase Sdr
FORC16_0924	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
FORC16_0926	COG2056	Na+-H+ antiporter family
FORC16_0927	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
FORC16_0928	COG2885	chlorophyll binding
FORC16_0930	COG0346	lactoylglutathione lyase activity
FORC16_0931	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
FORC16_0933	COG4659	FMN binding
FORC16_0935	COG4656	Part of a membrane complex involved in electron transport
FORC16_0942	COG0391	Required for morphogenesis under gluconeogenic growth conditions
FORC16_0944	COG0521	Mo-molybdopterin cofactor biosynthetic process
FORC16_0946	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
FORC16_0947	COG0314	molybdopterin synthase activity
FORC16_0949	COG0601	transmembrane transport
FORC16_0950	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FORC16_0951	COG0444	Belongs to the ABC transporter superfamily
FORC16_0953	COG0435	Glutathione S-transferase
FORC16_0955	COG2350	Protein conserved in bacteria
FORC16_0956	COG1607	acyl-coa hydrolase
FORC16_0959	COG1301	dicarboxylic acid transport
FORC16_0962	COG0134	indole-3-glycerol-phosphate synthase activity
FORC16_0962	COG0135	phosphoribosylanthranilate isomerase activity
FORC16_0964	COG0512	Glutamine amidotransferase of anthranilate synthase
FORC16_0965	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
FORC16_0966	COG0613	PHP domain protein
FORC16_0967	COG0009	L-threonylcarbamoyladenylate synthase
FORC16_0973	COG5001	Diguanylate cyclase
FORC16_0974	COG0417	DNA replication proofreading
FORC16_0975	COG2197	response regulator
FORC16_0985	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FORC16_0986	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FORC16_0993	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
FORC16_0994	COG0437	4 iron, 4 sulfur cluster binding
FORC16_0995	COG3301	Polysulphide reductase, NrfD
FORC16_0996	COG1138	Cytochrome C-type biogenesis protein
FORC16_0997	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FORC16_0998	COG4235	cytochrome complex assembly
FORC16_0998	COG3088	subunit of a heme lyase
FORC16_1001	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FORC16_1001	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FORC16_1002	COG0489	protein tyrosine kinase activity
FORC16_1005	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
FORC16_1006	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FORC16_1007	COG0659	secondary active sulfate transmembrane transporter activity
FORC16_1008	COG1530	ribonuclease E activity
FORC16_1011	COG1399	metal-binding, possibly nucleic acid-binding protein
FORC16_1014	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FORC16_1020	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
FORC16_1023	COG0084	hydrolase, TatD family'
FORC16_1024	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FORC16_1024	COG1263	PTS System
FORC16_1026	COG0733	neurotransmitter:sodium symporter activity
FORC16_1029	COG4667	esterase of the alpha-beta hydrolase superfamily
FORC16_1030	COG0469	pyruvate kinase activity
FORC16_1031	COG1940	carbohydrate kinase activity
FORC16_1032	COG0784	Response regulator, receiver
FORC16_1032	COG0835	chemotaxis
FORC16_1033	COG0587	DNA-directed DNA polymerase activity
FORC16_1036	COG1028	Short-chain dehydrogenase reductase Sdr
FORC16_1037	COG0616	signal peptide processing
FORC16_1039	COG0539	negative regulation of cytoplasmic translation
FORC16_1041	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
FORC16_1042	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
FORC16_1043	COG0284	orotidine-5'-phosphate decarboxylase activity
FORC16_1044	COG4174	ABC transporter (Permease)
FORC16_1045	COG4239	(ABC) transporter, permease
FORC16_1046	COG4166	transmembrane transport
FORC16_1047	COG0444	Belongs to the ABC transporter superfamily
FORC16_1048	COG4608	Belongs to the ABC transporter superfamily
FORC16_1053	COG0583	DNA-binding transcription factor activity
FORC16_1055	COG0686	Belongs to the AlaDH PNT family
FORC16_1059	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
FORC16_1067	COG0501	Belongs to the peptidase M48B family
FORC16_1069	COG1028	Short-chain dehydrogenase reductase Sdr
FORC16_1072	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
FORC16_1076	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
FORC16_1080	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FORC16_1081	COG2916	Histone family protein nucleoid-structuring protein H-NS
FORC16_1082	COG1757	Na H antiporter
FORC16_1084	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
FORC16_1085	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FORC16_1086	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
FORC16_1086	COG0131	Imidazoleglycerol-phosphate dehydratase
FORC16_1087	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
FORC16_1091	COG3012	SEC-C Motif Domain Protein
FORC16_1092	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
FORC16_1093	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FORC16_1094	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
FORC16_1096	COG1435	thymidine kinase activity
FORC16_1098	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FORC16_1099	COG0583	DNA-binding transcription factor activity
FORC16_1103	COG2116	formate transmembrane transporter activity
FORC16_1104	COG0390	transport system, permease component
FORC16_1105	COG4459	periplasmic nitrate reductase
FORC16_1106	COG3005	denitrification pathway
FORC16_1107	COG0243	molybdopterin cofactor binding
FORC16_1113	COG1227	inorganic diphosphatase activity
FORC16_1116	COG4172	Belongs to the ABC transporter superfamily
FORC16_1118	COG4171	peptide transport system, permease
FORC16_1119	COG4168	peptide transport system, permease
FORC16_1121	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
FORC16_1122	COG1842	Phage shock protein A
FORC16_1124	COG1983	PspC domain protein
FORC16_1128	COG2818	Glycosylase
FORC16_1129	COG0626	cystathionine gamma-synthase activity
FORC16_1131	COG0733	neurotransmitter:sodium symporter activity
FORC16_1133	COG0564	pseudouridine synthase activity
FORC16_1135	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FORC16_1136	COG1151	hydroxylamine reductase activity
FORC16_1137	COG3604	Transcriptional regulator
FORC16_1138	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
FORC16_1139	COG4136	ATPase activity
FORC16_1140	COG4135	transport system, permease component
FORC16_1141	COG4134	Bacterial extracellular solute-binding protein
FORC16_1143	COG3313	Fe-S protein
FORC16_1150	COG2205	protein histidine kinase activity
FORC16_1151	COG0745	RESPONSE REGULATOR receiver
FORC16_1153	COG1061	Type III restriction enzyme res subunit
FORC16_1155	COG2814	Major facilitator Superfamily
FORC16_1158	COG0702	epimerase
FORC16_1159	COG1136	(ABC) transporter
FORC16_1166	COG3273	potassium ion transport
FORC16_1166	COG2985	domain, Protein
FORC16_1167	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
FORC16_1168	COG1979	alcohol dehydrogenase
FORC16_1169	COG1737	Transcriptional regulator
FORC16_1170	COG0076	glutamate decarboxylase activity
FORC16_1172	COG2431	L-lysine efflux transmembrane transporter activity
FORC16_1174	COG3070	regulator of competence-specific genes
FORC16_1177	COG5002	protein histidine kinase activity
FORC16_1177	COG5002	protein histidine kinase activity
FORC16_1179	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
FORC16_1180	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
FORC16_1181	COG4988	ABC transporter
FORC16_1182	COG0492	ferredoxin-NADP+ reductase activity
FORC16_1186	COG3706	GGDEF domain
FORC16_1186	COG0745	RESPONSE REGULATOR receiver
FORC16_1187	COG0471	metal ion transport
FORC16_1188	COG2949	membrane
FORC16_1189	COG0281	malic enzyme
FORC16_1195	COG1346	cytolysis
FORC16_1196	COG1380	Effector of murein hydrolase LrgA
FORC16_1197	COG2925	Exonuclease
FORC16_1205	COG2988	succinylglutamate desuccinylase activity
FORC16_1207	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
FORC16_1211	COG0583	DNA-binding transcription factor activity
FORC16_1214	COG1451	nucleotide metabolic process
FORC16_1217	COG3063	Type IV pilus biogenesis stability protein PilW
FORC16_1220	COG2195	Cleaves the N-terminal amino acid of tripeptides
FORC16_1222	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
FORC16_1224	COG0625	glutathione transferase activity
FORC16_1229	COG1278	Cold shock
FORC16_1231	COG0584	glycerophosphoryl diester phosphodiesterase
FORC16_1232	COG1349	DNA-binding transcription factor activity
FORC16_1234	COG0395	ABC-type sugar transport system, permease component
FORC16_1235	COG1175	transmembrane transport
FORC16_1236	COG1653	transport
FORC16_1239	COG0730	response to heat
FORC16_1241	COG2197	response regulator
FORC16_1250	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
FORC16_1254	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
FORC16_1255	COG0372	Belongs to the citrate synthase family
FORC16_1257	COG2828	Protein conserved in bacteria
FORC16_1265	COG0561	phosphatase activity
FORC16_1266	COG0602	queuosine metabolic process
FORC16_1268	COG3706	GGDEF domain
FORC16_1273	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
FORC16_1275	COG1254	Belongs to the acylphosphatase family
FORC16_1276	COG2920	part of a sulfur-relay system
FORC16_1277	COG0670	Belongs to the BI1 family
FORC16_1278	COG1126	abc transporter atp-binding protein
FORC16_1279	COG0765	amino acid transport
FORC16_1280	COG4597	amino acid ABC transporter
FORC16_1281	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FORC16_1283	COG0437	4 iron, 4 sulfur cluster binding
FORC16_1284	COG0348	domain, Protein
FORC16_1285	COG0204	Acyl-transferase
FORC16_1286	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
FORC16_1289	COG1115	amino acid carrier protein
FORC16_1296	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FORC16_1299	COG3290	protein histidine kinase activity
FORC16_1300	COG4565	transcriptional regulatory protein
FORC16_1301	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
FORC16_1302	COG0363	glucosamine-6-phosphate deaminase activity
FORC16_1303	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
FORC16_1310	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
FORC16_1312	COG0438	transferase activity, transferring glycosyl groups
FORC16_1315	COG0110	maltose O-acetyltransferase activity
FORC16_1321	COG2204	response regulator
FORC16_1327	COG1366	Belongs to the anti-sigma-factor antagonist family
FORC16_1328	COG1793	dna ligase
FORC16_1329	COG3706	GGDEF domain
FORC16_1331	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
FORC16_1334	COG2996	Protein conserved in bacteria
FORC16_1336	COG3008	intermembrane lipid transfer
FORC16_1337	COG2995	paraquat-inducible protein a
FORC16_1338	COG1132	(ABC) transporter
FORC16_1339	COG1956	GAF domain-containing protein
FORC16_1343	COG0308	aminopeptidase N
FORC16_1345	COG2902	Dehydrogenase
FORC16_1348	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
FORC16_1348	COG0116	Belongs to the methyltransferase superfamily
FORC16_1350	COG0488	(ABC) transporter
FORC16_1354	COG1067	ATP-dependent peptidase activity
FORC16_1355	COG3120	sequence-specific DNA binding
FORC16_1362	COG3278	Belongs to the heme-copper respiratory oxidase family
FORC16_1365	COG2010	Cytochrome c
FORC16_1367	COG2217	Heavy metal translocating P-type atpase
FORC16_1370	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FORC16_1371	COG0589	response to stress
FORC16_1374	COG2992	FlgJ-related protein
FORC16_1377	COG1176	ABC-type spermidine putrescine transport system, permease component I
FORC16_1378	COG1177	transmembrane transport
FORC16_1379	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
FORC16_1380	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
FORC16_1381	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
FORC16_1382	COG0004	ammonium transporteR
FORC16_1387	COG0437	4 iron, 4 sulfur cluster binding
FORC16_1388	COG3383	formate dehydrogenase (NAD+) activity
FORC16_1388	COG0243	molybdopterin cofactor binding
FORC16_1394	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
FORC16_1396	COG0488	(ABC) transporter
FORC16_1399	COG3852	Histidine kinase
FORC16_1400	COG2204	response regulator
FORC16_1402	COG4662	Binding-protein-dependent transport system inner membrane component
FORC16_1403	COG3842	ATPase activity
FORC16_1404	COG0746	molybdenum cofactor guanylyltransferase activity
FORC16_1410	COG3290	protein histidine kinase activity
FORC16_1410	COG0840	transmembrane signaling receptor activity
FORC16_1411	COG0791	NLP P60 protein
FORC16_1413	COG3706	GGDEF domain
FORC16_1417	COG0307	riboflavin synthase, alpha
FORC16_1418	COG0534	Mate efflux family protein
FORC16_1431	COG2963	transposase activity
FORC16_1432	COG2801	Transposase and inactivated derivatives
FORC16_1443	COG2944	sequence-specific DNA binding
FORC16_1444	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
FORC16_1487	COG4628	conserved protein (DUF2132)
FORC16_1496	COG2963	transposase activity
FORC16_1497	COG2801	Transposase and inactivated derivatives
FORC16_1509	COG1280	lysine exporter protein (LysE YggA)
FORC16_1520	COG0384	phenazine biosynthesis protein PhzF
FORC16_1523	COG0251	oxidation-reduction process
FORC16_1525	COG1942	4-Oxalocrotonate Tautomerase
FORC16_1550	COG1942	4-Oxalocrotonate Tautomerase
FORC16_1636	COG4628	conserved protein (DUF2132)
FORC16_1649	COG4326	sporulation control protein
FORC16_1650	COG2188	Transcriptional regulator
FORC16_1651	COG1228	amidohydrolase
FORC16_1656	COG5640	endopeptidase activity
FORC16_1657	COG2020	methyltransferase activity
FORC16_1658	COG0277	FAD linked oxidase domain protein
FORC16_1658	COG0247	lactate metabolic process
FORC16_1661	COG2885	chlorophyll binding
FORC16_1664	COG0295	cytidine deaminase activity
FORC16_1672	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FORC16_1672	COG0072	phenylalanine-tRNA ligase activity
FORC16_1674	COG3706	GGDEF domain
FORC16_1674	COG0745	RESPONSE REGULATOR receiver
FORC16_1687	COG0010	Belongs to the arginase family
FORC16_1688	COG2814	Major facilitator Superfamily
FORC16_1689	COG5380	lipid catabolic process
FORC16_1690	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
FORC16_1695	COG1643	Atp-dependent helicase
FORC16_1697	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
FORC16_1705	COG2894	cell division
FORC16_1707	COG4964	Belongs to the GSP D family
FORC16_1717	COG3706	GGDEF domain
FORC16_1720	COG0443	Heat shock 70 kDa protein
FORC16_1721	COG0443	Heat shock 70 kDa protein
FORC16_1729	COG0297	glycogen (starch) synthase activity
FORC16_1729	COG0438	transferase activity, transferring glycosyl groups
FORC16_1730	COG0438	transferase activity, transferring glycosyl groups
FORC16_1735	COG1596	polysaccharide export
FORC16_1738	COG1115	amino acid carrier protein
FORC16_1739	COG1132	(ABC) transporter
FORC16_1740	COG1132	(ABC) transporter
FORC16_1743	COG0783	Belongs to the Dps family
FORC16_1746	COG0814	amino acid
FORC16_1747	COG1597	lipid kinase activity
FORC16_1749	COG4667	esterase of the alpha-beta hydrolase superfamily
FORC16_1750	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
FORC16_1753	COG0583	DNA-binding transcription factor activity
FORC16_1754	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
FORC16_1755	COG1328	CTP reductase activity
FORC16_1756	COG5001	Diguanylate cyclase
FORC16_1756	COG3300	MHYT domain
FORC16_1759	COG2200	EAL domain
FORC16_1759	COG2199	diguanylate cyclase activity
FORC16_1760	COG3706	GGDEF domain
FORC16_1762	COG4191	Histidine kinase
FORC16_1762	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FORC16_1763	COG0471	metal ion transport
FORC16_1766	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FORC16_1767	COG3283	Transcriptional regulator of aromatic amino acids metabolism
FORC16_1768	COG3768	UPF0283 membrane protein
FORC16_1769	COG3106	COG3106 Predicted ATPase
FORC16_1772	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
FORC16_1775	COG0494	nUDIX hydrolase
FORC16_1776	COG0814	amino acid
FORC16_1777	COG1760	l-serine dehydratase
FORC16_1778	COG2200	EAL domain
FORC16_1780	COG0720	synthase
FORC16_1781	COG0840	transmembrane signaling receptor activity
FORC16_1784	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FORC16_1787	COG3437	response regulator, receiver
FORC16_1787	COG2770	Histidine kinase
FORC16_1788	COG1448	Aminotransferase
FORC16_1792	COG0840	transmembrane signaling receptor activity
FORC16_1793	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FORC16_1794	COG1846	Transcriptional regulator
FORC16_1799	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
FORC16_1802	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FORC16_1803	COG3108	Peptidase M15
FORC16_1804	COG2989	Protein conserved in bacteria
FORC16_1811	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
FORC16_1813	COG0653	protein targeting
FORC16_1815	COG0745	RESPONSE REGULATOR receiver
FORC16_1815	COG3706	GGDEF domain
FORC16_1816	COG0366	Alpha amylase catalytic
FORC16_1818	COG4120	Belongs to the binding-protein-dependent transport system permease family
FORC16_1820	COG3092	negative regulation of chromosome organization
FORC16_1822	COG0857	belongs to the CobB CobQ family
FORC16_1822	COG0280	phosphate acetyltransferase
FORC16_1824	COG0583	DNA-binding transcription factor activity
FORC16_1829	COG1032	radical SAM domain protein
FORC16_1833	COG2207	Transcriptional regulator
FORC16_1841	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FORC16_1844	COG0861	Integral membrane protein TerC family
FORC16_1845	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FORC16_1846	COG0840	transmembrane signaling receptor activity
FORC16_1847	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FORC16_1850	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
FORC16_1856	COG2801	Transposase and inactivated derivatives
FORC16_1860	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
FORC16_1861	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
FORC16_1870	COG0784	Response regulator, receiver
FORC16_1870	COG2205	protein histidine kinase activity
FORC16_1872	COG0754	glutathionylspermidine amidase activity
FORC16_1874	COG3766	membrane
FORC16_1876	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
FORC16_1877	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
FORC16_1878	COG2885	chlorophyll binding
FORC16_1879	COG0823	Involved in the tonB-independent uptake of proteins
FORC16_1882	COG0811	peptide transport
FORC16_1883	COG0824	Thioesterase
FORC16_1885	COG1294	oxidase, subunit
FORC16_1886	COG1271	oxidase subunit
FORC16_1887	COG2255	four-way junction helicase activity
FORC16_1889	COG0840	transmembrane signaling receptor activity
FORC16_1890	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
FORC16_1891	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
FORC16_1893	COG4106	trans-aconitate 2-methyltransferase activity
FORC16_1895	COG0189	ligase activity
FORC16_1895	COG4067	protein conserved in archaea
FORC16_1901	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
FORC16_1903	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
FORC16_1904	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FORC16_1905	COG1434	Gram-negative-bacterium-type cell wall biogenesis
FORC16_1906	COG0745	RESPONSE REGULATOR receiver
FORC16_1907	COG3381	protein complex oligomerization
FORC16_1909	COG3070	regulator of competence-specific genes
FORC16_1913	COG0297	glycogen (starch) synthase activity
FORC16_1914	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
FORC16_1915	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FORC16_1918	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
FORC16_1921	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
FORC16_1922	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
FORC16_1923	COG0542	response to heat
FORC16_1925	COG1278	Cold shock
FORC16_1929	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
FORC16_1930	COG1199	ATP-dependent helicase activity
FORC16_1932	COG3923	Primosomal replication protein n
FORC16_1934	COG0840	transmembrane signaling receptor activity
FORC16_1935	COG0708	Exodeoxyribonuclease III
FORC16_1938	COG4215	(ABC) transporter
FORC16_1943	COG1882	Formate acetyltransferase
FORC16_1946	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
FORC16_1949	COG2766	serine protein kinase
FORC16_1950	COG2718	Belongs to the UPF0229 family
FORC16_1951	COG2719	SpoVR family
FORC16_1952	COG2199	diguanylate cyclase activity
FORC16_1953	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
FORC16_1955	COG1663	tetraacyldisaccharide 4'-kinase activity
FORC16_1957	COG0658	competence protein
FORC16_1957	COG2333	competence protein COMEC
FORC16_1959	COG4591	ABC-type transport system involved in lipoprotein release permease component
FORC16_1961	COG4591	ABC-type transport system involved in lipoprotein release permease component
FORC16_1963	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
FORC16_1966	COG1252	NADH dehydrogenase
FORC16_1972	COG0537	adenosine 5'-monophosphoramidase activity
FORC16_1977	COG4109	DRTGG domain
FORC16_1978	COG3706	GGDEF domain
FORC16_1979	COG1982	Orn Lys Arg decarboxylase major
FORC16_1980	COG0531	amino acid
FORC16_1981	COG3710	Transcriptional regulator
FORC16_1985	COG2199	diguanylate cyclase activity
FORC16_1985	COG2203	Gaf domain
FORC16_1986	COG2239	Acts as a magnesium transporter
FORC16_1987	COG0582	viral genome integration into host DNA
FORC16_1989	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
FORC16_2005	COG2226	methyltransferase
FORC16_2009	COG1785	Belongs to the alkaline phosphatase family
FORC16_2011	COG0346	lactoylglutathione lyase activity
FORC16_2013	COG2983	Belongs to the UPF0260 family
FORC16_2016	COG0745	RESPONSE REGULATOR receiver
FORC16_2017	COG2205	protein histidine kinase activity
FORC16_2021	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
FORC16_2025	COG0745	RESPONSE REGULATOR receiver
FORC16_2026	COG0583	DNA-binding transcription factor activity
FORC16_2027	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
FORC16_2028	COG1286	toxin biosynthetic process
FORC16_2029	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
FORC16_2030	COG0285	dihydrofolate synthase activity
FORC16_2034	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
FORC16_2036	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FORC16_2039	COG3101	peptidyl-lysine hydroxylation
FORC16_2040	COG2860	membrane
FORC16_2041	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
FORC16_2042	COG2890	protein-(glutamine-N5) methyltransferase activity
FORC16_2043	COG2840	Smr protein MutS2
FORC16_2044	COG2062	phosphohistidine phosphatase, SixA
FORC16_2045	COG1025	Belongs to the peptidase M16 family
FORC16_2050	COG2067	long-chain fatty acid transport protein
FORC16_2051	COG2067	long-chain fatty acid transport protein
FORC16_2052	COG2853	Lipoprotein
FORC16_2054	COG3088	subunit of a heme lyase
FORC16_2054	COG4235	cytochrome complex assembly
FORC16_2055	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FORC16_2056	COG1138	Cytochrome C-type biogenesis protein
FORC16_2058	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FORC16_2059	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FORC16_2060	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FORC16_2061	COG4133	protoheme IX ABC transporter activity
FORC16_2063	COG0835	chemotaxis
FORC16_2065	COG1192	Involved in chromosome partitioning
FORC16_2066	COG2201	protein-glutamate methylesterase activity
FORC16_2067	COG2198	Histidine kinase
FORC16_2067	COG0643	Histidine kinase
FORC16_2068	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
FORC16_2071	COG0455	bacterial-type flagellum organization
FORC16_2075	COG1684	flagellar biosynthetic protein fliR
FORC16_2076	COG1987	bacterial-type flagellum assembly
FORC16_2086	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
FORC16_2088	COG1677	Flagellar hook-basal body complex protein FliE
FORC16_2089	COG2204	response regulator
FORC16_2090	COG4191	Histidine kinase
FORC16_2091	COG2204	response regulator
FORC16_2092	COG1516	flagellar protein fliS
FORC16_2094	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
FORC16_2095	COG1334	flagellar protein FlaG
FORC16_2096	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FORC16_2097	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FORC16_2098	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FORC16_2099	COG2837	iron assimilation
FORC16_2105	COG1393	Belongs to the ArsC family
FORC16_2110	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FORC16_2111	COG2716	regulation of RNA biosynthetic process
FORC16_2112	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
FORC16_2115	COG4783	chaperone-mediated protein folding
FORC16_2116	COG1393	Belongs to the ArsC family
FORC16_2120	COG2233	PERMEase
FORC16_2121	COG2963	transposase activity
FORC16_2122	COG2801	Transposase and inactivated derivatives
FORC16_2123	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
FORC16_2125	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
FORC16_2126	COG0121	glutamine amidotransferase
FORC16_2128	COG1960	acyl-CoA dehydrogenase activity
FORC16_2136	COG2249	NAD(P)H dehydrogenase (quinone) activity
FORC16_2138	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
FORC16_2140	COG2226	methyltransferase
FORC16_2141	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FORC16_2142	COG1388	LysM domain
FORC16_2142	COG0741	lytic transglycosylase activity
FORC16_2144	COG3021	interspecies interaction between organisms
FORC16_2145	COG0347	Belongs to the P(II) protein family
FORC16_2149	COG0587	DNA-directed DNA polymerase activity
FORC16_2154	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FORC16_2155	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
FORC16_2156	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FORC16_2157	COG0750	zinc metalloprotease
FORC16_2158	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
FORC16_2159	COG0575	Belongs to the CDS family
FORC16_2161	COG0233	cytoplasmic translational termination
FORC16_2165	COG0024	Methionine aminopeptidase
FORC16_2166	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
FORC16_2169	COG3098	single-species biofilm formation
FORC16_2175	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
FORC16_2177	COG0254	rRNA binding
FORC16_2178	COG1720	tRNA m6t6A37 methyltransferase activity
FORC16_2183	COG0733	neurotransmitter:sodium symporter activity
FORC16_2186	COG0514	ATP-dependent DNA helicase (RecQ)
FORC16_2188	COG3706	GGDEF domain
FORC16_2188	COG0745	RESPONSE REGULATOR receiver
FORC16_2190	COG1477	protein flavinylation
FORC16_2197	COG0271	Belongs to the BolA IbaG family
FORC16_2201	COG2211	Major facilitator Superfamily
FORC16_2203	COG1595	DNA-templated transcription, initiation
FORC16_2205	COG3248	Nucleoside-binding outer membrane protein
FORC16_2206	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
FORC16_2207	COG0693	protein deglycase activity
FORC16_2208	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
FORC16_2209	COG2166	iron-sulfur cluster assembly
FORC16_2210	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
FORC16_2211	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
FORC16_2215	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FORC16_2216	COG1074	ATP-dependent DNA helicase activity
FORC16_2217	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
FORC16_2218	COG3083	sulfuric ester hydrolase activity
FORC16_2221	COG3141	response to X-ray
FORC16_2222	COG2171	N-acyltransferase activity
FORC16_2223	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
FORC16_2225	COG1349	DNA-binding transcription factor activity
FORC16_2226	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
FORC16_2229	COG0569	domain protein
FORC16_2229	COG0189	ligase activity
FORC16_2233	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FORC16_2235	COG0840	transmembrane signaling receptor activity
FORC16_2236	COG2017	converts alpha-aldose to the beta-anomer
FORC16_2239	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
FORC16_2240	COG1609	Transcriptional regulator
FORC16_2242	COG3250	beta-galactosidase activity
FORC16_2243	COG2731	YhcH YjgK YiaL family protein
FORC16_2244	COG0531	amino acid
FORC16_2245	COG0531	amino acid
FORC16_2246	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
FORC16_2246	COG3408	Glycogen debranching enzyme
FORC16_2248	COG0583	DNA-binding transcription factor activity
FORC16_2249	COG2059	Chromate
FORC16_2259	COG4964	Belongs to the GSP D family
FORC16_2266	COG1022	Amp-dependent synthetase and ligase
FORC16_2268	COG0583	DNA-binding transcription factor activity
FORC16_2269	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
FORC16_2273	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
FORC16_2275	COG0560	Phosphoserine phosphatase
FORC16_2280	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
FORC16_2281	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
FORC16_2282	COG0084	hydrolase, TatD family'
FORC16_2284	COG3706	GGDEF domain
FORC16_2286	COG0456	acetyltransferase
FORC16_2288	COG3153	acetyltransferase
FORC16_2293	COG0534	Mate efflux family protein
FORC16_2295	COG4785	May be involved in cell division
FORC16_2306	COG0195	Participates in both transcription termination and antitermination
FORC16_2308	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
FORC16_2310	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FORC16_2311	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
FORC16_2312	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FORC16_2314	COG1534	Rna-binding protein
FORC16_2317	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
FORC16_2318	COG2027	D-alanyl-D-alanine carboxypeptidase
FORC16_2319	COG2832	Protein of unknown function (DUF454)
FORC16_2321	COG0739	heme binding
FORC16_2324	COG0316	Belongs to the HesB IscA family
FORC16_2326	COG0628	permease
FORC16_2328	COG0784	Response regulator, receiver
FORC16_2328	COG2205	protein histidine kinase activity
FORC16_2330	COG0601	transmembrane transport
FORC16_2331	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FORC16_2332	COG0444	Belongs to the ABC transporter superfamily
FORC16_2333	COG4608	Belongs to the ABC transporter superfamily
FORC16_2335	COG2971	BadF BadG BcrA BcrD
FORC16_2338	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FORC16_2341	COG1840	ABC-type Fe3 transport system, periplasmic component
FORC16_2342	COG0004	ammonium transporteR
FORC16_2343	COG0347	Belongs to the P(II) protein family
FORC16_2345	COG3835	regulator
FORC16_2346	COG2610	gluconate transmembrane transporter activity
FORC16_2347	COG1929	Belongs to the glycerate kinase type-1 family
FORC16_2348	COG1049	propionate catabolic process, 2-methylcitrate cycle
FORC16_2349	COG1752	Esterase of the alpha-beta hydrolase superfamily
FORC16_2350	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FORC16_2351	COG1643	Atp-dependent helicase
FORC16_2352	COG1489	DNA binding
FORC16_2353	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
FORC16_2356	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
FORC16_2359	COG0842	Transport permease protein
FORC16_2360	COG1131	(ABC) transporter
FORC16_2361	COG0659	secondary active sulfate transmembrane transporter activity
FORC16_2362	COG0288	reversible hydration of carbon dioxide
FORC16_2365	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FORC16_2366	COG0508	dehydrogenase complex catalyzes the overall conversion of
FORC16_2367	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
FORC16_2368	COG2186	Transcriptional regulator
FORC16_2370	COG3023	N-Acetylmuramoyl-L-alanine amidase
FORC16_2373	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
FORC16_2374	COG1459	type II secretion system
FORC16_2376	COG0237	dephospho-CoA kinase activity
FORC16_2379	COG0335	large ribosomal subunit rRNA binding
FORC16_2383	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
FORC16_2384	COG4137	Cytochrome C assembly protein
FORC16_2385	COG4536	flavin adenine dinucleotide binding
FORC16_2388	COG2918	glutathione biosynthetic process
FORC16_2389	COG0612	Peptidase, M16
FORC16_2390	COG1238	metal cluster binding
FORC16_2392	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
FORC16_2393	COG5016	pyruvate
FORC16_2393	COG0511	ligase activity, forming carbon-carbon bonds
FORC16_2396	COG0527	aspartate kinase activity
FORC16_2398	COG2137	regulation of response to DNA damage stimulus
FORC16_2401	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
FORC16_2402	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FORC16_2403	COG4942	peptidase
FORC16_2403	COG1388	LysM domain
FORC16_2407	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
FORC16_2408	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
FORC16_2412	COG3956	TIGRFAM MazG family protein
FORC16_2413	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FORC16_2414	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
FORC16_2415	COG3850	Histidine kinase
FORC16_2415	COG3437	response regulator, receiver
FORC16_2415	COG2205	protein histidine kinase activity
FORC16_2415	COG4999	Histidine kinase
FORC16_2416	COG5001	Diguanylate cyclase
FORC16_2421	COG1381	Involved in DNA repair and RecF pathway recombination
FORC16_2424	COG0681	Belongs to the peptidase S26 family
FORC16_2426	COG3086	response to oxidative stress
FORC16_2429	COG1595	DNA-templated transcription, initiation
FORC16_2430	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
FORC16_2432	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
FORC16_2433	COG0354	folic acid binding
FORC16_2436	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FORC16_2437	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FORC16_2438	COG3079	Belongs to the UPF0149 family
FORC16_2439	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
FORC16_2440	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
FORC16_2441	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
FORC16_2442	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FORC16_2445	COG1279	arginine transmembrane transporter activity
FORC16_2446	COG0668	transmembrane transport
FORC16_2447	COG0191	fructose-bisphosphate aldolase activity
FORC16_2455	COG2356	endonuclease I
FORC16_2456	COG1385	rRNA (uridine-N3-)-methyltransferase activity
FORC16_2462	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
FORC16_2463	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
FORC16_2464	COG0762	integral membrane protein
FORC16_2465	COG1872	DUF167
FORC16_2468	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FORC16_2473	COG0741	lytic transglycosylase activity
FORC16_2477	COG3437	response regulator, receiver
FORC16_2479	COG1609	Transcriptional regulator
FORC16_2481	COG1486	melibiose metabolic process
FORC16_2482	COG1447	Phosphotransferase system cellobiose-specific component IIA
FORC16_2484	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
FORC16_2485	COG0726	polysaccharide deacetylase
FORC16_2487	COG0795	lipopolysaccharide-transporting ATPase activity
FORC16_2488	COG0795	lipopolysaccharide-transporting ATPase activity
FORC16_2490	COG2927	DNA polymerase III (CHI subunit)
FORC16_2493	COG0456	acetyltransferase
FORC16_2497	COG2235	arginine
FORC16_2501	COG0251	oxidation-reduction process
FORC16_2502	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FORC16_2505	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
FORC16_2506	COG0312	modulator of DNA gyrase
FORC16_2507	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FORC16_2508	COG3164	Protein of unknown function
FORC16_2509	COG1530	ribonuclease E activity
FORC16_2511	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
FORC16_2512	COG1792	Involved in formation and maintenance of cell shape
FORC16_2513	COG1077	Cell shape determining protein MreB Mrl
FORC16_2522	COG1459	type II secretion system
FORC16_2523	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
FORC16_2525	COG3267	Type II secretory pathway component ExeA
FORC16_2525	COG3409	Peptidoglycan-binding domain 1 protein
FORC16_2530	COG2199	diguanylate cyclase activity
FORC16_2530	COG2200	EAL domain
FORC16_2534	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
FORC16_2536	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
FORC16_2537	COG0527	aspartate kinase activity
FORC16_2538	COG1410	methionine synthase
FORC16_2538	COG0646	methionine synthase
FORC16_2540	COG0745	RESPONSE REGULATOR receiver
FORC16_2540	COG3706	GGDEF domain
FORC16_2543	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FORC16_2549	COG0735	belongs to the Fur family
FORC16_2552	COG0432	Pfam Uncharacterised protein family UPF0047
FORC16_2554	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
FORC16_2555	COG0305	Participates in initiation and elongation during chromosome replication
FORC16_2561	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
FORC16_2562	COG0338	D12 class N6 adenine-specific DNA methyltransferase
FORC16_2571	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
FORC16_2576	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
FORC16_2578	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FORC16_2579	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
FORC16_2581	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
FORC16_2582	COG0460	homoserine dehydrogenase
FORC16_2582	COG0527	aspartate kinase activity
FORC16_2583	COG0626	cystathionine gamma-synthase activity
FORC16_2585	COG0281	malic enzyme
FORC16_2587	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
FORC16_2588	COG1609	Transcriptional regulator
FORC16_2592	COG1575	Belongs to the MenA family. Type 1 subfamily
FORC16_2595	COG1494	fructose-1,6-bisphosphatase
FORC16_2601	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
FORC16_2603	COG2906	2 iron, 2 sulfur cluster binding
FORC16_2605	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
FORC16_2608	COG2168	tRNA wobble position uridine thiolation
FORC16_2610	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
FORC16_2611	COG2964	Protein conserved in bacteria
FORC16_2612	COG0545	Peptidyl-prolyl cis-trans isomerase
FORC16_2616	COG1047	Peptidyl-prolyl cis-trans
FORC16_2619	COG2249	NAD(P)H dehydrogenase (quinone) activity
FORC16_2620	COG0488	(ABC) transporter
FORC16_2622	COG0429	hydrolase of the alpha beta-hydrolase fold
FORC16_2624	COG3954	Phosphoribulokinase
FORC16_2625	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FORC16_2629	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FORC16_2636	COG0557	exoribonuclease II activity
FORC16_2637	COG0402	S-adenosylhomocysteine deaminase activity
FORC16_2640	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
FORC16_2641	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
FORC16_2642	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
FORC16_2643	COG0330	HflC and HflK could
FORC16_2644	COG0330	HflC and HflK could
FORC16_2645	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
FORC16_2649	COG0860	N-Acetylmuramoyl-L-alanine amidase
FORC16_2650	COG0802	atpase or kinase
FORC16_2651	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
FORC16_2655	COG0471	metal ion transport
FORC16_2657	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
FORC16_2659	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FORC16_2662	COG1045	serine acetyltransferase
FORC16_2663	COG4942	peptidase
FORC16_2669	COG1053	succinate dehydrogenase
FORC16_2670	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
FORC16_2672	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
FORC16_2675	COG1509	lysine 2,3-aminomutase activity
FORC16_2676	COG1285	pathogenesis
FORC16_2680	COG0534	Mate efflux family protein
FORC16_2683	COG3678	ATP-independent chaperone mediated protein folding
FORC16_2684	COG0745	RESPONSE REGULATOR receiver
FORC16_2685	COG2205	protein histidine kinase activity
FORC16_2687	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
FORC16_2689	COG1027	Aspartate ammonia-lyase
FORC16_2690	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
FORC16_2691	COG4232	protein-disulfide reductase activity
FORC16_2693	COG2095	MarC family integral membrane protein
FORC16_2695	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FORC16_2696	COG2205	protein histidine kinase activity
FORC16_2696	COG0784	Response regulator, receiver
FORC16_2696	COG2198	Histidine kinase
FORC16_2697	COG2814	Major facilitator Superfamily
FORC16_2700	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FORC16_2702	COG0511	ligase activity, forming carbon-carbon bonds
FORC16_2703	COG0439	Biotin carboxylase
FORC16_2704	COG2264	protein methyltransferase activity
FORC16_2706	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
FORC16_2707	COG0840	transmembrane signaling receptor activity
FORC16_2708	COG0789	Transcriptional regulator
FORC16_2713	COG1253	flavin adenine dinucleotide binding
FORC16_2714	COG3068	Protein conserved in bacteria
FORC16_2715	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FORC16_2716	COG1573	uracil-dna glycosylase
FORC16_2721	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
FORC16_2729	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
FORC16_2731	COG1072	(Pantothenic acid kinase))
FORC16_2733	COG0812	UDP-N-acetylmuramate dehydrogenase activity
FORC16_2735	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FORC16_2738	COG3335	DDE superfamily endonuclease
FORC16_2742	COG4206	TonB-dependent receptor
FORC16_2752	COG1580	Controls the rotational direction of flagella during chemotaxis
FORC16_2753	COG0705	Rhomboid family
FORC16_2756	COG2177	Part of the ABC transporter FtsEX involved in
FORC16_2757	COG2884	Cell division ATP-binding protein ftsE
FORC16_2758	COG0552	protein localization to endoplasmic reticulum
FORC16_2759	COG0742	ribosomal rna small subunit methyltransferase
FORC16_2761	COG2095	MarC family integral membrane protein
FORC16_2770	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
FORC16_2771	COG0640	Transcriptional regulator
FORC16_2772	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
FORC16_2773	COG1280	lysine exporter protein (LysE YggA)
FORC16_2774	COG2267	carboxylic ester hydrolase activity
FORC16_2775	COG0561	phosphatase activity
FORC16_2779	COG3287	FIST C domain
FORC16_2779	COG2200	EAL domain
FORC16_2779	COG2199	diguanylate cyclase activity
FORC16_2780	COG1011	Hydrolase
FORC16_2784	COG0019	diaminopimelate decarboxylase activity
FORC16_2787	COG3072	Adenylate cyclase
FORC16_2790	COG2959	enzyme of heme biosynthesis
FORC16_2792	COG2081	HI0933 family
FORC16_2794	COG1528	Iron-storage protein
FORC16_2795	COG0589	response to stress
FORC16_2799	COG5001	Diguanylate cyclase
FORC16_2799	COG5002	protein histidine kinase activity
FORC16_2800	COG1522	sequence-specific DNA binding
FORC16_2802	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
FORC16_2803	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FORC16_2804	COG0800	Aldolase
FORC16_2806	COG3265	gluconokinase activity
FORC16_2807	COG0129	dihydroxy-acid dehydratase activity
FORC16_2808	COG1609	Transcriptional regulator
FORC16_2811	COG2815	serine threonine protein kinase
FORC16_2811	COG0515	serine threonine protein kinase
FORC16_2818	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FORC16_2820	COG4166	transmembrane transport
FORC16_2821	COG4172	Belongs to the ABC transporter superfamily
FORC16_2825	COG1309	transcriptional regulator
FORC16_2826	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FORC16_2827	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FORC16_2828	COG2960	long-chain fatty acid transporting porin activity
FORC16_2830	COG0583	DNA-binding transcription factor activity
FORC16_2832	COG3335	DDE superfamily endonuclease
FORC16_2833	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
FORC16_2835	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
FORC16_2836	COG0408	coproporphyrinogen oxidase activity
FORC16_2840	COG0551	DNA topoisomerase type I activity
FORC16_2842	COG0758	DNA mediated transformation
FORC16_2845	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
FORC16_2846	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FORC16_2846	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
FORC16_2847	COG0569	domain protein
FORC16_2848	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FORC16_2849	COG1272	protein, Hemolysin III
FORC16_2850	COG4326	sporulation control protein
FORC16_2852	COG3084	Protein conserved in bacteria
FORC16_2854	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
FORC16_2855	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FORC16_2856	COG0204	Acyl-transferase
FORC16_2858	COG0606	chelatase, subunit chli
FORC16_2860	COG3978	acetolactate synthase activity
FORC16_2861	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
FORC16_2862	COG0129	dihydroxy-acid dehydratase activity
FORC16_2864	COG0583	DNA-binding transcription factor activity
FORC16_2865	COG2814	Major facilitator Superfamily
FORC16_2867	COG0765	amino acid transport
FORC16_2868	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
FORC16_2877	COG3312	ion transport
FORC16_2878	COG1475	DNA binding
FORC16_2879	COG1192	Involved in chromosome partitioning
FORC16_2882	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
FORC16_2883	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
FORC16_2884	COG0706	membrane insertase activity
FORC16_2887	COG1126	abc transporter atp-binding protein
FORC16_2893	COG4608	Belongs to the ABC transporter superfamily
FORC16_2894	COG0444	Belongs to the ABC transporter superfamily
FORC16_2896	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FORC16_2896	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
FORC16_2900	COG0217	transcriptional regulatory protein
FORC16_2902	COG0583	DNA-binding transcription factor activity
FORC16_2904	COG1136	(ABC) transporter
FORC16_2905	COG4591	ABC-type transport system involved in lipoprotein release permease component
FORC16_2908	COG3275	phosphorelay sensor kinase activity
FORC16_2912	COG0786	glutamate:sodium symporter activity
FORC16_2913	COG0786	glutamate:sodium symporter activity
FORC16_2918	COG0189	ligase activity
FORC16_2923	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
FORC16_2924	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
FORC16_2926	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
FORC16_2931	COG1309	transcriptional regulator
FORC16_2936	COG1741	Belongs to the pirin family
FORC16_2938	COG5001	Diguanylate cyclase
FORC16_2940	COG3706	GGDEF domain
FORC16_2951	COG1982	Orn Lys Arg decarboxylase major
FORC16_2952	COG0531	amino acid
FORC16_2953	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
FORC16_2959	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FORC16_2960	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
FORC16_2961	COG1162	GTPase activity
FORC16_2962	COG2847	Copper chaperone PCu(A)C
FORC16_2963	COG1999	signal sequence binding
FORC16_2969	COG3833	ABC-type maltose transport systems, permease component
FORC16_2970	COG1175	transmembrane transport
FORC16_2971	COG2182	Extracellular solute-binding protein
FORC16_2973	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FORC16_2975	COG3842	ATPase activity
FORC16_2980	COG0058	SHG alpha-glucan phosphorylase activity
FORC16_2981	COG1640	4-alpha-glucanotransferase
FORC16_2984	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FORC16_2991	COG0560	Phosphoserine phosphatase
FORC16_2994	COG1012	belongs to the aldehyde dehydrogenase family
FORC16_2995	COG0625	glutathione transferase activity
FORC16_2997	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
FORC16_2998	COG1283	sodium-dependent phosphate transmembrane transporter activity
FORC16_2999	COG0612	Peptidase, M16
FORC16_3002	COG0583	DNA-binding transcription factor activity
FORC16_3003	COG0583	DNA-binding transcription factor activity
FORC16_3004	COG0387	Pfam Sodium calcium exchanger
FORC16_3005	COG0586	Pfam SNARE associated Golgi protein
FORC16_3008	COG0642	Histidine kinase
FORC16_3009	COG0745	RESPONSE REGULATOR receiver
FORC16_3010	COG2199	diguanylate cyclase activity
FORC16_3014	COG1609	Transcriptional regulator
FORC16_3017	COG0395	ABC-type sugar transport system, permease component
FORC16_3020	COG1609	Transcriptional regulator
FORC16_3022	COG0747	negative chemotaxis
FORC16_3025	COG0444	Belongs to the ABC transporter superfamily
FORC16_3026	COG4608	Belongs to the ABC transporter superfamily
FORC16_3028	COG1609	Transcriptional regulator
FORC16_3029	COG4580	involved in the transport of maltose and maltodextrins
FORC16_3036	COG4580	involved in the transport of maltose and maltodextrins
FORC16_3038	COG1472	Belongs to the glycosyl hydrolase 3 family
FORC16_3039	COG0534	Mate efflux family protein
FORC16_3041	COG1566	PFAM secretion protein HlyD family protein
FORC16_3049	COG0564	pseudouridine synthase activity
FORC16_3051	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FORC16_3054	COG1609	Transcriptional regulator
FORC16_3056	COG1129	ABC transporter
FORC16_3060	COG2211	Major facilitator Superfamily
FORC16_3061	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FORC16_3062	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
FORC16_3064	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
FORC16_3066	COG2207	Transcriptional regulator
FORC16_3066	COG3708	Transcriptional regulator
FORC16_3079	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FORC16_3079	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FORC16_3079	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FORC16_3080	COG2207	Transcriptional regulator
FORC16_3082	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FORC16_3083	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FORC16_3086	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FORC16_3088	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
FORC16_3095	COG3383	formate dehydrogenase (NAD+) activity
FORC16_3097	COG1609	Transcriptional regulator
FORC16_3098	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FORC16_3098	COG1263	PTS System
FORC16_3099	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
FORC16_3101	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
FORC16_3105	COG0768	penicillin binding
FORC16_3108	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
FORC16_3113	COG0583	DNA-binding transcription factor activity
FORC16_3116	COG0137	argininosuccinate synthase activity
FORC16_3118	COG1301	dicarboxylic acid transport
FORC16_3129	COG2175	clavaminate synthase activity
FORC16_3136	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FORC16_3138	COG3706	GGDEF domain
FORC16_3141	COG2356	endonuclease I
FORC16_3144	COG1368	sulfuric ester hydrolase activity
FORC16_3145	COG2194	sulfuric ester hydrolase activity
FORC16_3146	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
FORC16_3147	COG2205	protein histidine kinase activity
FORC16_3148	COG0745	RESPONSE REGULATOR receiver
FORC16_3151	COG4221	oxidoreductase activity
FORC16_3156	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FORC16_3157	COG0076	glutamate decarboxylase activity
FORC16_3160	COG0561	phosphatase activity
FORC16_3163	COG0671	phosphoesterase, PA-phosphatase related
FORC16_3164	COG0351	phosphomethylpyrimidine kinase
FORC16_3173	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
FORC16_3174	COG4771	TonB-dependent receptor
FORC16_3178	COG0393	Putative heavy-metal-binding
FORC16_3181	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
FORC16_3187	COG0753	catalase activity
FORC16_3191	COG0346	lactoylglutathione lyase activity
FORC16_3194	COG2211	Major facilitator Superfamily
FORC16_3198	COG3240	lipase activity
FORC16_3200	COG1063	alcohol dehydrogenase
FORC16_3216	COG3040	lipid binding
FORC16_3223	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
FORC16_3225	COG2197	response regulator
FORC16_3226	COG2199	diguanylate cyclase activity
FORC16_3229	COG2205	protein histidine kinase activity
FORC16_3229	COG0784	Response regulator, receiver
FORC16_3230	COG3111	PFAM Bacterial OB fold (BOF) protein
FORC16_3232	COG2274	protein secretion by the type I secretion system
FORC16_3234	COG1538	Outer membrane efflux protein
FORC16_3238	COG0668	transmembrane transport
FORC16_3243	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FORC16_3244	COG0793	Belongs to the peptidase S41A family
FORC16_3244	COG4946	Tricorn protease homolog
FORC16_3247	COG1122	ATPase activity
FORC16_3248	COG4720	Psort location CytoplasmicMembrane, score
FORC16_3249	COG1566	PFAM secretion protein HlyD family protein
FORC16_3251	COG3706	GGDEF domain
FORC16_3255	COG3272	Protein of unknown function (DUF1722)
FORC16_3256	COG0789	Transcriptional regulator
FORC16_3257	COG0415	Belongs to the DNA photolyase family
FORC16_3258	COG1388	LysM domain
FORC16_3258	COG1376	ErfK ybiS ycfS ynhG family protein
FORC16_3260	COG0513	Belongs to the DEAD box helicase family
FORC16_3268	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
FORC16_3269	COG0573	inorganic phosphate transmembrane transporter activity
FORC16_3270	COG0581	inorganic phosphate transmembrane transporter activity
FORC16_3272	COG2203	Gaf domain
FORC16_3272	COG4251	negative regulation of phosphorylation
FORC16_3272	COG5001	Diguanylate cyclase
FORC16_3272	COG3706	GGDEF domain
FORC16_3274	COG2304	oxidoreductase activity
FORC16_3278	COG0714	Associated with various cellular activities
FORC16_3291	COG3206	protein involved in exopolysaccharide biosynthesis
FORC16_3291	COG0489	protein tyrosine kinase activity
FORC16_3292	COG1596	polysaccharide export
FORC16_3294	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
FORC16_3304	COG2354	Protein conserved in bacteria
FORC16_3306	COG0418	dihydroorotase activity
FORC16_3307	COG0633	Ferredoxin
FORC16_3307	COG3217	Mosc domain protein beta barrel domain protein
FORC16_3307	COG0633	Ferredoxin
FORC16_3307	COG3217	Mosc domain protein beta barrel domain protein
FORC16_3318	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FORC16_3320	COG0848	biopolymer transport protein
FORC16_3321	COG0811	peptide transport
FORC16_3322	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
FORC16_3324	COG3721	Heme iron utilization protein
FORC16_3325	COG0748	coenzyme F420 binding
FORC16_3327	COG0835	chemotaxis
FORC16_3327	COG0784	Response regulator, receiver
FORC16_3328	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FORC16_3329	COG0589	response to stress
FORC16_3330	COG0366	Alpha amylase catalytic
FORC16_3332	COG0840	transmembrane signaling receptor activity
FORC16_3339	COG0739	heme binding
FORC16_3341	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
FORC16_3343	COG2084	Dehydrogenase
FORC16_3347	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
FORC16_3351	COG0840	transmembrane signaling receptor activity
FORC16_3354	COG3706	GGDEF domain
FORC16_3355	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FORC16_3355	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FORC16_3356	COG1765	OsmC-like protein
FORC16_3357	COG2171	N-acyltransferase activity
FORC16_3362	COG1011	Hydrolase
FORC16_3367	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FORC16_3368	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
FORC16_3368	COG2207	Transcriptional regulator
FORC16_3371	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
FORC16_3372	COG1840	ABC-type Fe3 transport system, periplasmic component
FORC16_3373	COG3842	ATPase activity
FORC16_3377	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FORC16_3378	COG0583	DNA-binding transcription factor activity
FORC16_3381	COG1760	l-serine dehydratase
FORC16_3385	COG1686	Belongs to the peptidase S11 family
FORC16_3389	COG3059	membrane
FORC16_3396	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
FORC16_3398	COG0247	lactate metabolic process
FORC16_3401	COG1619	proteins homologs of microcin C7 resistance protein MccF
FORC16_3402	COG2133	pyrroloquinoline quinone binding
FORC16_3404	COG1454	alcohol dehydrogenase
FORC16_3405	COG0443	Heat shock 70 kDa protein
FORC16_3406	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FORC16_3413	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FORC16_3414	COG3174	membrane
FORC16_3419	COG0814	amino acid
FORC16_3420	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
FORC16_3425	COG2962	Rard protein
FORC16_3428	COG0671	phosphoesterase, PA-phosphatase related
FORC16_3430	COG1288	antiporter activity
FORC16_3433	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
FORC16_3437	COG2315	Protein conserved in bacteria
FORC16_3442	COG1129	ABC transporter
FORC16_3443	COG1172	Belongs to the binding-protein-dependent transport system permease family
FORC16_3444	COG1879	ABC-type sugar transport system periplasmic component
FORC16_3445	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FORC16_3446	COG1609	Transcriptional regulator
FORC16_3448	COG0835	chemotaxis
FORC16_3448	COG0784	Response regulator, receiver
FORC16_3450	COG0456	acetyltransferase
FORC16_3453	COG1366	Belongs to the anti-sigma-factor antagonist family
FORC16_3455	COG2172	sigma factor antagonist activity
FORC16_3457	COG5002	protein histidine kinase activity
FORC16_3457	COG2205	protein histidine kinase activity
FORC16_3457	COG0784	Response regulator, receiver
FORC16_3458	COG3437	response regulator, receiver
FORC16_3459	COG0420	3'-5' exonuclease activity
FORC16_3460	COG0419	ATPase involved in DNA repair
FORC16_3462	COG0583	DNA-binding transcription factor activity
FORC16_3466	COG4964	Belongs to the GSP D family
FORC16_3477	COG2801	Transposase and inactivated derivatives
FORC16_3478	COG2963	transposase activity
FORC16_3483	COG0471	metal ion transport
FORC16_3484	COG3290	protein histidine kinase activity
FORC16_3486	COG0110	maltose O-acetyltransferase activity
FORC16_3491	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FORC16_3492	COG4605	iron ion homeostasis
FORC16_3493	COG4604	ABC transporter, ATP-binding protein
FORC16_3494	COG0789	Transcriptional regulator
FORC16_3496	COG1629	transport
FORC16_3496	COG4771	TonB-dependent receptor
FORC16_3503	COG1289	transmembrane transporter activity
FORC16_3504	COG0210	DNA helicase
FORC16_3506	COG1879	ABC-type sugar transport system periplasmic component
FORC16_3507	COG2205	protein histidine kinase activity
FORC16_3507	COG2198	Histidine kinase
FORC16_3507	COG0784	Response regulator, receiver
FORC16_3511	COG1262	PFAM Formylglycine-generating sulfatase enzyme
FORC16_3512	COG3005	denitrification pathway
FORC16_3517	COG0513	Belongs to the DEAD box helicase family
FORC16_3519	COG5001	Diguanylate cyclase
FORC16_3519	COG1716	ATPase activity
FORC16_3524	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
FORC16_3527	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
FORC16_3528	COG0513	Belongs to the DEAD box helicase family
FORC16_3536	COG3706	GGDEF domain
FORC16_3549	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
FORC16_3550	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
FORC16_3553	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
FORC16_3555	COG4804	nuclease activity
FORC16_3573	COG2433	Pfam Transposase IS66
FORC16_3574	COG3550	peptidyl-serine autophosphorylation
FORC16_3575	COG1733	regulation of RNA biosynthetic process
FORC16_3577	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
FORC16_3586	COG2801	Transposase and inactivated derivatives
FORC16_3590	COG3119	arylsulfatase activity
FORC16_3592	COG3119	arylsulfatase activity
FORC16_3593	COG0641	radical SAM
FORC16_3594	COG0714	Associated with various cellular activities
FORC16_3600	COG0583	DNA-binding transcription factor activity
FORC16_3601	COG1524	type I phosphodiesterase nucleotide pyrophosphatase
FORC16_3603	COG0641	radical SAM
FORC16_3609	COG2814	Major facilitator Superfamily
FORC16_3613	COG0583	DNA-binding transcription factor activity
FORC16_3614	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
FORC16_3617	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FORC16_3619	COG1132	(ABC) transporter
FORC16_3622	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
FORC16_3624	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FORC16_3624	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FORC16_3626	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
FORC16_3635	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FORC16_3635	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
FORC16_3635	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FORC16_3636	COG1105	Belongs to the carbohydrate kinase PfkB family
FORC16_3637	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
FORC16_3637	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
FORC16_3638	COG1609	Transcriptional regulator
FORC16_3643	COG0469	pyruvate kinase activity
FORC16_3644	COG2271	Major facilitator Superfamily
FORC16_3645	COG1840	ABC-type Fe3 transport system, periplasmic component
FORC16_3646	COG4191	Histidine kinase
FORC16_3648	COG2801	Transposase and inactivated derivatives
FORC16_3649	COG2963	transposase activity
FORC16_3650	COG1979	alcohol dehydrogenase
FORC16_3651	COG2207	Transcriptional regulator
FORC16_3653	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
FORC16_3654	COG2759	Belongs to the formate--tetrahydrofolate ligase family
FORC16_3655	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FORC16_3658	COG3437	response regulator, receiver
FORC16_3658	COG0784	Response regulator, receiver
FORC16_3659	COG0546	phosphoglycolate phosphatase activity
FORC16_3660	COG0840	transmembrane signaling receptor activity
FORC16_3662	COG0513	Belongs to the DEAD box helicase family
FORC16_3665	COG3038	cytochrome b561
FORC16_3667	COG2116	formate transmembrane transporter activity
FORC16_3668	COG0583	DNA-binding transcription factor activity
FORC16_3670	COG3593	DNA synthesis involved in DNA repair
FORC16_3671	COG0737	Belongs to the 5'-nucleotidase family
FORC16_3672	COG0861	Integral membrane protein TerC family
FORC16_3678	COG2267	carboxylic ester hydrolase activity
FORC16_3679	COG2067	long-chain fatty acid transport protein
FORC16_3682	COG2050	protein possibly involved in aromatic compounds catabolism
FORC16_3684	COG4533	DNA binding
FORC16_3687	COG0583	DNA-binding transcription factor activity
FORC16_3691	COG0484	heat shock protein binding
FORC16_3694	COG5001	Diguanylate cyclase
FORC16_3694	COG1716	ATPase activity
FORC16_3695	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
FORC16_3697	COG4181	ATPase activity
FORC16_3698	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
FORC16_3699	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FORC16_3699	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
FORC16_3700	COG1984	allophanate hydrolase subunit 2
FORC16_3701	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
FORC16_3702	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
FORC16_3704	COG5002	protein histidine kinase activity
FORC16_3704	COG5001	Diguanylate cyclase
FORC16_3704	COG3447	MASE1 domain protein
FORC16_3706	COG0583	DNA-binding transcription factor activity
FORC16_3707	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FORC16_3707	COG0045	succinate-CoA ligase (ADP-forming) activity
FORC16_3707	COG1042	CoA-binding domain protein
FORC16_3709	COG1181	Belongs to the D-alanine--D-alanine ligase family
FORC16_3711	COG0023	Translation Initiation Factor
FORC16_3712	COG3140	Belongs to the UPF0181 family
FORC16_3715	COG0745	RESPONSE REGULATOR receiver
FORC16_3717	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
FORC16_3718	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
FORC16_3721	COG3706	GGDEF domain
FORC16_3723	COG0745	RESPONSE REGULATOR receiver
FORC16_3725	COG1846	Transcriptional regulator
FORC16_3726	COG0697	spore germination
FORC16_3727	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
FORC16_3728	COG4149	molybdate abc transporter
FORC16_3729	COG0725	ABC transporter, periplasmic molybdate-binding protein
FORC16_3733	COG0189	ligase activity
FORC16_3733	COG4067	protein conserved in archaea
FORC16_3735	COG0840	transmembrane signaling receptor activity
FORC16_3736	COG0602	queuosine metabolic process
FORC16_3737	COG1328	CTP reductase activity
FORC16_3748	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FORC16_3749	COG3118	belongs to the thioredoxin family
FORC16_3750	COG0477	Major facilitator Superfamily
FORC16_3752	COG0534	Mate efflux family protein
FORC16_3755	COG0840	transmembrane signaling receptor activity
FORC16_3756	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
FORC16_3759	COG0848	biopolymer transport protein
FORC16_3760	COG0811	peptide transport
FORC16_3761	COG0811	peptide transport
FORC16_3767	COG2146	nitrite reductase [NAD(P)H] activity
FORC16_3768	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FORC16_3769	COG0840	transmembrane signaling receptor activity
FORC16_3774	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
FORC16_3776	COG2203	Gaf domain
FORC16_3776	COG5001	Diguanylate cyclase
FORC16_3776	COG4251	negative regulation of phosphorylation
FORC16_3776	COG3706	GGDEF domain
FORC16_3778	COG0010	Belongs to the arginase family
FORC16_3779	COG0513	Belongs to the DEAD box helicase family
FORC16_3781	COG0523	cobalamin synthesis protein
FORC16_3783	COG2199	diguanylate cyclase activity
FORC16_3786	COG2146	nitrite reductase [NAD(P)H] activity
FORC16_3786	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FORC16_3787	COG1116	anion transmembrane transporter activity
FORC16_3788	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FORC16_3789	COG1116	anion transmembrane transporter activity
FORC16_3789	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FORC16_3790	COG3707	response regulator
FORC16_3793	COG1648	precorrin-2 dehydrogenase activity
FORC16_3793	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
FORC16_3794	COG0243	molybdopterin cofactor binding
FORC16_3796	COG0366	Alpha amylase catalytic
FORC16_3797	COG0366	Alpha amylase catalytic
FORC16_3798	COG0840	transmembrane signaling receptor activity
FORC16_3799	COG0840	transmembrane signaling receptor activity
FORC16_3802	COG2271	Major facilitator Superfamily
FORC16_3803	COG0584	glycerophosphoryl diester phosphodiesterase
FORC16_3804	COG0312	modulator of DNA gyrase
FORC16_3805	COG0312	modulator of DNA gyrase
FORC16_3807	COG3069	C4-dicarboxylate transmembrane transporter activity
FORC16_3808	COG1704	LemA family
FORC16_3809	COG0501	Belongs to the peptidase M48B family
FORC16_3812	COG3209	COG3209 Rhs family protein
FORC16_3816	COG3209	COG3209 Rhs family protein
FORC16_3818	COG3209	COG3209 Rhs family protein
FORC16_3823	COG3209	COG3209 Rhs family protein
FORC16_3828	COG3209	COG3209 Rhs family protein
FORC16_3831	COG3501	Rhs element vgr protein
FORC16_3842	COG0631	protein serine/threonine phosphatase activity
FORC16_3849	COG0515	serine threonine protein kinase
FORC16_3849	COG2815	serine threonine protein kinase
FORC16_3853	COG3530	Putative quorum-sensing-regulated virulence factor
FORC16_3858	COG3186	Phenylalanine-4-hydroxylase
FORC16_3859	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FORC16_3865	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
FORC16_3867	COG4191	Histidine kinase
FORC16_3867	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FORC16_3868	COG3437	response regulator, receiver
FORC16_3868	COG0784	Response regulator, receiver
FORC16_3881	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
FORC16_3881	COG3064	Membrane
FORC16_3881	COG1073	alpha beta
FORC16_3882	COG2994	toxin metabolic process
FORC16_3887	COG1028	Short-chain dehydrogenase reductase Sdr
FORC16_3889	COG1024	Enoyl-CoA hydratase
FORC16_3890	COG1024	Enoyl-CoA hydratase
FORC16_3891	COG1960	acyl-CoA dehydrogenase activity
FORC16_3893	COG0183	Belongs to the thiolase family
FORC16_3895	COG1960	acyl-CoA dehydrogenase activity
FORC16_3896	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FORC16_3899	COG0450	alkyl hydroperoxide reductase
FORC16_3901	COG1278	Cold shock
FORC16_3903	COG1309	transcriptional regulator
FORC16_3904	COG2130	NADP-dependent
FORC16_3908	COG2197	response regulator
FORC16_3909	COG3851	Histidine kinase
FORC16_3910	COG2271	Major facilitator Superfamily
FORC16_3911	COG1482	cell wall glycoprotein biosynthetic process
FORC16_3912	COG2199	diguanylate cyclase activity
FORC16_3912	COG2203	Gaf domain
FORC16_3914	COG3036	rescue of stalled ribosome
FORC16_3915	COG1278	Cold shock
FORC16_3922	COG0545	Peptidyl-prolyl cis-trans isomerase
FORC16_3923	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FORC16_3924	COG0840	transmembrane signaling receptor activity
FORC16_3928	COG2195	Cleaves the N-terminal amino acid of tripeptides
FORC16_3930	COG4989	oxidoreductase activity
FORC16_3936	COG1914	H( )-stimulated, divalent metal cation uptake system
FORC16_3938	COG0303	'Molybdopterin
FORC16_3939	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
FORC16_3941	COG2897	thiosulfate sulfurtransferase activity
FORC16_3945	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
FORC16_3946	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
FORC16_3949	COG0840	transmembrane signaling receptor activity
FORC16_3951	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
FORC16_3952	COG2885	chlorophyll binding
FORC16_3953	COG0109	protoheme IX farnesyltransferase activity
FORC16_3954	COG1612	heme a metabolic process
FORC16_3959	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
FORC16_3960	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
FORC16_3961	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
FORC16_3962	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FORC16_3964	COG1280	lysine exporter protein (LysE YggA)
FORC16_3969	COG1846	Transcriptional regulator
FORC16_3970	COG1764	response to oxidative stress
FORC16_3972	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FORC16_3975	COG0697	spore germination
FORC16_3978	COG2814	Major facilitator Superfamily
FORC16_3979	COG0583	DNA-binding transcription factor activity
FORC16_3980	COG5001	Diguanylate cyclase
FORC16_3980	COG2203	Gaf domain
FORC16_3980	COG3706	GGDEF domain
FORC16_3980	COG4251	negative regulation of phosphorylation
FORC16_3981	COG0251	oxidation-reduction process
FORC16_3984	COG4145	pantothenate transmembrane transporter activity
FORC16_3986	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
FORC16_3988	COG0837	glucose binding
FORC16_3988	COG1737	Transcriptional regulator
FORC16_3990	COG1131	(ABC) transporter
FORC16_3991	COG0842	Transport permease protein
FORC16_3997	COG1846	Transcriptional regulator
FORC16_4000	COG0513	Belongs to the DEAD box helicase family
FORC16_4008	COG3568	Endonuclease Exonuclease Phosphatase
FORC16_4011	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FORC16_4020	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
FORC16_4020	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
FORC16_4024	COG2197	response regulator
FORC16_4025	COG3850	Histidine kinase
FORC16_4026	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
FORC16_4028	COG0243	molybdopterin cofactor binding
FORC16_4030	COG3005	denitrification pathway
FORC16_4031	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
FORC16_4032	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
FORC16_4033	COG1737	Transcriptional regulator
FORC16_4034	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FORC16_4035	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
FORC16_4036	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
FORC16_4037	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
FORC16_4039	COG1940	carbohydrate kinase activity
FORC16_4040	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
FORC16_4044	COG0183	Belongs to the thiolase family
FORC16_4046	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FORC16_4047	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FORC16_4056	COG1879	ABC-type sugar transport system periplasmic component
FORC16_4058	COG2827	Endonuclease containing a URI domain
FORC16_4059	COG3132	Protein of unknown function, DUF480
FORC16_4062	COG0534	Mate efflux family protein
FORC16_4063	COG5002	protein histidine kinase activity
FORC16_4063	COG2205	protein histidine kinase activity
FORC16_4063	COG0784	Response regulator, receiver
FORC16_4068	COG0583	DNA-binding transcription factor activity
FORC16_4073	COG1522	sequence-specific DNA binding
FORC16_4075	COG0531	amino acid
FORC16_4076	COG0121	glutamine amidotransferase
FORC16_4079	COG2205	protein histidine kinase activity
FORC16_4080	COG0745	RESPONSE REGULATOR receiver
FORC16_4085	COG2239	Acts as a magnesium transporter
FORC16_4087	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
FORC16_4088	COG0402	S-adenosylhomocysteine deaminase activity
FORC16_4089	COG1067	ATP-dependent peptidase activity
FORC16_4091	COG4172	Belongs to the ABC transporter superfamily
FORC16_4092	COG1505	serine-type exopeptidase activity
FORC16_4093	COG0583	DNA-binding transcription factor activity
FORC16_4094	COG1620	l-lactate permease
FORC16_4096	COG1139	Iron-sulfur cluster binding protein
FORC16_4101	COG2814	Major facilitator Superfamily
FORC16_4106	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
FORC16_4109	COG3015	lipoprotein NlpE involved in copper resistance
FORC16_4110	COG1126	abc transporter atp-binding protein
FORC16_4111	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FORC16_4112	COG4215	(ABC) transporter
FORC16_4113	COG4160	amino acid transport
FORC16_4116	COG5001	Diguanylate cyclase
FORC16_4116	COG5002	protein histidine kinase activity
FORC16_4117	COG2755	lipolytic protein G-D-S-L family
FORC16_4119	COG0840	transmembrane signaling receptor activity
FORC16_4120	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FORC16_4126	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
FORC16_4127	COG1028	Short-chain dehydrogenase reductase Sdr
FORC16_4128	COG1169	isochorismate synthase
FORC16_4129	COG1021	2,3-dihydroxybenzoate-AMP ligase
FORC16_4133	COG1021	2,3-dihydroxybenzoate-AMP ligase
FORC16_4135	COG4607	ABC-type enterochelin transport system periplasmic component
FORC16_4136	COG4774	siderophore transport
FORC16_4136	COG1629	transport
FORC16_4140	COG4067	protein conserved in archaea
FORC16_4140	COG0189	ligase activity
FORC16_4146	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FORC16_4149	COG0745	RESPONSE REGULATOR receiver
FORC16_4153	COG0814	amino acid
FORC16_4154	COG0488	(ABC) transporter
FORC16_4157	COG1609	Transcriptional regulator
FORC16_4158	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FORC16_4163	COG1253	flavin adenine dinucleotide binding
FORC16_4164	COG1012	belongs to the aldehyde dehydrogenase family
FORC16_4166	COG3284	Transcriptional regulator
FORC16_4168	COG1879	ABC-type sugar transport system periplasmic component
FORC16_4169	COG0625	glutathione transferase activity
FORC16_4171	COG0384	phenazine biosynthesis protein PhzF
FORC16_4172	COG2197	response regulator
FORC16_4174	COG0673	inositol 2-dehydrogenase activity
FORC16_4175	COG2067	long-chain fatty acid transport protein
FORC16_4179	COG2015	COG2015, Alkyl sulfatase and related hydrolases
FORC16_4181	COG0583	DNA-binding transcription factor activity
FORC16_4182	COG2194	sulfuric ester hydrolase activity
FORC16_4183	COG0798	PFAM Bile acid sodium symporter
FORC16_4184	COG0640	Transcriptional regulator
FORC16_4188	COG0583	DNA-binding transcription factor activity
FORC16_4192	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FORC16_4193	COG0700	Nucleoside recognition
FORC16_4194	COG3366	ferrous iron transmembrane transporter activity
FORC16_4196	COG0366	Alpha amylase catalytic
FORC16_4197	COG0823	Involved in the tonB-independent uptake of proteins
FORC16_4198	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FORC16_4206	COG0800	Aldolase
FORC16_4207	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FORC16_4208	COG0697	spore germination
FORC16_4209	COG0657	acetylesterase activity
FORC16_4210	COG0583	DNA-binding transcription factor activity
FORC16_4211	COG0583	DNA-binding transcription factor activity
FORC16_4219	COG1917	Cupin 2, conserved barrel domain protein
FORC16_4221	COG1028	Short-chain dehydrogenase reductase Sdr
FORC16_4230	COG0668	transmembrane transport
FORC16_4236	COG0494	nUDIX hydrolase
FORC16_4237	COG1881	PFAM PEBP family protein
FORC16_4238	COG2207	Transcriptional regulator
FORC16_4242	COG0745	RESPONSE REGULATOR receiver
FORC16_4243	COG2205	protein histidine kinase activity
FORC16_4247	COG0454	-acetyltransferase
FORC16_4248	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
FORC16_4253	COG1858	cytochrome C peroxidase
FORC16_4257	COG0583	DNA-binding transcription factor activity
FORC16_4261	COG2814	Major facilitator Superfamily
FORC16_4268	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FORC16_4271	COG0583	DNA-binding transcription factor activity
FORC16_4275	COG0513	Belongs to the DEAD box helicase family
FORC16_4282	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FORC16_4284	COG1357	PFAM Pentapeptide repeats (8 copies)
FORC16_4288	COG3437	response regulator, receiver
FORC16_4290	COG0579	oxidoreductase
FORC16_4296	COG2015	COG2015, Alkyl sulfatase and related hydrolases
FORC16_4299	COG2205	protein histidine kinase activity
FORC16_4303	COG0641	radical SAM
FORC16_4307	COG3119	arylsulfatase activity
FORC16_4309	COG0583	DNA-binding transcription factor activity
FORC16_4310	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
FORC16_4313	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
FORC16_4315	COG2176	DNA-directed DNA polymerase activity
FORC16_4316	COG1136	(ABC) transporter
FORC16_4316	COG0577	efflux transmembrane transporter activity
FORC16_4317	COG0577	efflux transmembrane transporter activity
FORC16_4317	COG1136	(ABC) transporter
FORC16_4323	COG1120	ATPase activity
FORC16_4324	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
FORC16_4330	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
FORC16_4331	COG3716	PTS system mannose fructose sorbose family IID component
FORC16_4333	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FORC16_4334	COG2222	sugar isomerase
FORC16_4336	COG1349	DNA-binding transcription factor activity
FORC16_4338	COG1349	DNA-binding transcription factor activity
FORC16_4339	COG2200	EAL domain
FORC16_4340	COG0697	spore germination
FORC16_4341	COG2207	Transcriptional regulator
FORC16_4345	COG2015	COG2015, Alkyl sulfatase and related hydrolases
FORC16_4355	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FORC16_4356	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FORC16_4360	COG0840	transmembrane signaling receptor activity
FORC16_4363	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
FORC16_4367	COG0583	DNA-binding transcription factor activity
FORC16_4368	COG1486	melibiose metabolic process
FORC16_4372	COG2258	MOSC domain
FORC16_4375	COG1757	Na H antiporter
FORC16_4376	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
FORC16_4377	COG0513	Belongs to the DEAD box helicase family
FORC16_4379	COG2186	Transcriptional regulator
FORC16_4381	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
FORC16_4383	COG0246	Mannitol dehydrogenase
FORC16_4384	COG1904	glucuronate isomerase
FORC16_4385	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FORC16_4386	COG0800	Aldolase
FORC16_4389	COG1028	Short-chain dehydrogenase reductase Sdr
FORC16_4390	COG2999	glutathione oxidoreductase activity
FORC16_4391	COG1902	pentaerythritol trinitrate reductase activity
FORC16_4397	COG0561	phosphatase activity
FORC16_4398	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
FORC16_4399	COG3623	hexulose-6-phosphate isomerase
FORC16_4402	COG1132	(ABC) transporter
FORC16_4407	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FORC16_4414	COG2204	response regulator
FORC16_4420	COG3069	C4-dicarboxylate transmembrane transporter activity
FORC16_4421	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
FORC16_4427	COG0110	maltose O-acetyltransferase activity
FORC16_4430	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
FORC16_4430	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FORC16_4431	COG1737	Transcriptional regulator
FORC16_4433	COG1263	PTS System
FORC16_4433	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FORC16_4435	COG2200	EAL domain
FORC16_4435	COG2199	diguanylate cyclase activity
FORC16_4435	COG2203	Gaf domain
FORC16_4436	COG0406	alpha-ribazole phosphatase activity
FORC16_4439	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
FORC16_4444	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
FORC16_4447	COG3706	GGDEF domain
FORC16_4447	COG0745	RESPONSE REGULATOR receiver
FORC16_4449	COG0840	transmembrane signaling receptor activity
FORC16_4450	COG2201	protein-glutamate methylesterase activity
FORC16_4452	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
FORC16_4453	COG0840	transmembrane signaling receptor activity
FORC16_4454	COG0835	chemotaxis
FORC16_4457	COG0745	RESPONSE REGULATOR receiver
FORC16_4459	COG1444	tRNA N-acetyltransferase activity