locus-tag	class	description
VV208B2_00020	COG0592	DNA-directed DNA polymerase activity
VV208B2_00040	COG0187	DNA topoisomerase II activity
VV208B2_00050	COG0071	Belongs to the small heat shock protein (HSP20) family
VV208B2_00070	COG3977	Valine--pyruvate aminotransferase
VV208B2_00100	COG0752	glycyl-tRNA synthetase alpha subunit
VV208B2_00110	COG2119	membrane
VV208B2_00140	COG0425	Belongs to the sulfur carrier protein TusA family
VV208B2_00170	COG0604	alcohol dehydrogenase
VV208B2_00180	COG0183	Belongs to the thiolase family
VV208B2_00200	COG1739	Uncharacterized protein family UPF0029
VV208B2_00210	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
VV208B2_00230	COG3335	DDE superfamily endonuclease
VV208B2_00270	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
VV208B2_00280	COG2960	long-chain fatty acid transporting porin activity
VV208B2_00290	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VV208B2_00300	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VV208B2_00310	COG1309	transcriptional regulator
VV208B2_00340	COG4172	Belongs to the ABC transporter superfamily
VV208B2_00350	COG4166	transmembrane transport
VV208B2_00360	COG0601	transmembrane transport
VV208B2_00370	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VV208B2_00440	COG2815	serine threonine protein kinase
VV208B2_00440	COG0515	serine threonine protein kinase
VV208B2_00460	COG0745	RESPONSE REGULATOR receiver
VV208B2_00470	COG1609	Transcriptional regulator
VV208B2_00480	COG0129	dihydroxy-acid dehydratase activity
VV208B2_00490	COG3265	gluconokinase activity
VV208B2_00500	COG2610	gluconate transmembrane transporter activity
VV208B2_00510	COG0800	Aldolase
VV208B2_00550	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VV208B2_00560	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
VV208B2_00580	COG1522	sequence-specific DNA binding
VV208B2_00590	COG5002	protein histidine kinase activity
VV208B2_00590	COG5001	Diguanylate cyclase
VV208B2_00630	COG0589	response to stress
VV208B2_00640	COG1528	Iron-storage protein
VV208B2_00660	COG2081	HI0933 family
VV208B2_00680	COG2959	enzyme of heme biosynthesis
VV208B2_00700	COG0181	hydroxymethylbilane synthase activity
VV208B2_00710	COG3072	Adenylate cyclase
VV208B2_00720	COG1965	Belongs to the frataxin family
VV208B2_00730	COG0019	diaminopimelate decarboxylase activity
VV208B2_00740	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
VV208B2_00760	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
VV208B2_00770	COG1011	Hydrolase
VV208B2_00780	COG2199	diguanylate cyclase activity
VV208B2_00780	COG3287	FIST C domain
VV208B2_00780	COG2200	EAL domain
VV208B2_00790	COG3148	PFAM DTW domain containing protein
VV208B2_00820	COG0561	phosphatase activity
VV208B2_00830	COG2267	carboxylic ester hydrolase activity
VV208B2_00840	COG1280	lysine exporter protein (LysE YggA)
VV208B2_00850	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
VV208B2_00860	COG0640	Transcriptional regulator
VV208B2_00870	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
VV208B2_00950	COG2095	MarC family integral membrane protein
VV208B2_00970	COG0742	ribosomal rna small subunit methyltransferase
VV208B2_00980	COG0552	protein localization to endoplasmic reticulum
VV208B2_00990	COG2884	Cell division ATP-binding protein ftsE
VV208B2_01000	COG2177	Part of the ABC transporter FtsEX involved in
VV208B2_01020	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VV208B2_01030	COG0705	Rhomboid family
VV208B2_01040	COG1580	Controls the rotational direction of flagella during chemotaxis
VV208B2_01070	COG2937	Belongs to the GPAT DAPAT family
VV208B2_01080	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
VV208B2_01100	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VV208B2_01160	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
VV208B2_01180	COG0514	ATP-dependent DNA helicase (RecQ)
VV208B2_01200	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
VV208B2_01240	COG2003	Belongs to the UPF0758 family
VV208B2_01270	COG3339	Conserved Protein
VV208B2_01360	COG4206	TonB-dependent receptor
VV208B2_01400	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
VV208B2_01420	COG0812	UDP-N-acetylmuramate dehydrogenase activity
VV208B2_01450	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
VV208B2_01460	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
VV208B2_01490	COG0081	regulation of translation
VV208B2_01500	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
VV208B2_01510	COG0222	ribosome binding
VV208B2_01520	COG0085	RNA polymerase activity
VV208B2_01530	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
VV208B2_01540	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
VV208B2_01580	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
VV208B2_01590	COG1573	uracil-dna glycosylase
VV208B2_01600	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
VV208B2_01610	COG3068	Protein conserved in bacteria
VV208B2_01620	COG1253	flavin adenine dinucleotide binding
VV208B2_01650	COG0151	Belongs to the GarS family
VV208B2_01660	COG0138	bifunctional purine biosynthesis protein purh
VV208B2_01670	COG0789	Transcriptional regulator
VV208B2_01680	COG0840	transmembrane signaling receptor activity
VV208B2_01690	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
VV208B2_01720	COG0439	Biotin carboxylase
VV208B2_01730	COG0511	ligase activity, forming carbon-carbon bonds
VV208B2_01740	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
VV208B2_01750	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
VV208B2_01790	COG2814	Major facilitator Superfamily
VV208B2_01800	COG0784	Response regulator, receiver
VV208B2_01800	COG2198	Histidine kinase
VV208B2_01800	COG2205	protein histidine kinase activity
VV208B2_01830	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
VV208B2_01850	COG2095	MarC family integral membrane protein
VV208B2_01870	COG4232	protein-disulfide reductase activity
VV208B2_01880	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
VV208B2_01890	COG1027	Aspartate ammonia-lyase
VV208B2_01910	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
VV208B2_01930	COG2205	protein histidine kinase activity
VV208B2_01940	COG0745	RESPONSE REGULATOR receiver
VV208B2_01950	COG3678	ATP-independent chaperone mediated protein folding
VV208B2_01970	COG0205	6-phosphofructokinase activity
VV208B2_01980	COG0534	Mate efflux family protein
VV208B2_01990	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
VV208B2_02000	COG0459	protein refolding
VV208B2_02020	COG1285	pathogenesis
VV208B2_02030	COG1509	lysine 2,3-aminomutase activity
VV208B2_02040	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
VV208B2_02060	COG3385	transposase activity
VV208B2_02070	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
VV208B2_02080	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
VV208B2_02090	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
VV208B2_02100	COG1053	succinate dehydrogenase
VV208B2_02110	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
VV208B2_02140	COG3385	transposase activity
VV208B2_02150	COG4942	peptidase
VV208B2_02160	COG1045	serine acetyltransferase
VV208B2_02170	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
VV208B2_02180	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
VV208B2_02190	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VV208B2_02230	COG0471	metal ion transport
VV208B2_02240	COG0688	phosphatidylethanolamine metabolic process
VV208B2_02250	COG1162	GTPase activity
VV208B2_02260	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
VV208B2_02270	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
VV208B2_02280	COG0802	atpase or kinase
VV208B2_02290	COG0860	N-Acetylmuramoyl-L-alanine amidase
VV208B2_02300	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
VV208B2_02320	COG1923	regulation of RNA biosynthetic process
VV208B2_02330	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
VV208B2_02340	COG0330	HflC and HflK could
VV208B2_02350	COG0330	HflC and HflK could
VV208B2_02360	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
VV208B2_02370	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
VV208B2_02380	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
VV208B2_02400	COG1959	2 iron, 2 sulfur cluster binding
VV208B2_02410	COG0402	S-adenosylhomocysteine deaminase activity
VV208B2_02420	COG0557	exoribonuclease II activity
VV208B2_02430	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
VV208B2_02490	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
VV208B2_02510	COG1012	belongs to the aldehyde dehydrogenase family
VV208B2_02530	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VV208B2_02540	COG3954	Phosphoribulokinase
VV208B2_02550	COG3089	Belongs to the UPF0270 family
VV208B2_02560	COG0429	hydrolase of the alpha beta-hydrolase fold
VV208B2_02580	COG0488	(ABC) transporter
VV208B2_02590	COG2249	NAD(P)H dehydrogenase (quinone) activity
VV208B2_02620	COG1047	Peptidyl-prolyl cis-trans
VV208B2_02640	COG2900	Belongs to the SlyX family
VV208B2_02660	COG0545	Peptidyl-prolyl cis-trans isomerase
VV208B2_02670	COG2964	Protein conserved in bacteria
VV208B2_02680	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
VV208B2_02690	COG2923	Belongs to the DsrF TusC family
VV208B2_02700	COG2168	tRNA wobble position uridine thiolation
VV208B2_02710	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
VV208B2_02720	COG0049	tRNA binding
VV208B2_02730	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
VV208B2_02750	COG2906	2 iron, 2 sulfur cluster binding
VV208B2_02770	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
VV208B2_02780	COG0149	triose-phosphate isomerase activity
VV208B2_02830	COG1494	fructose-1,6-bisphosphatase
VV208B2_02850	COG3074	FtsZ-dependent cytokinesis
VV208B2_02870	COG1575	Belongs to the MenA family. Type 1 subfamily
VV208B2_02880	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
VV208B2_02890	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
VV208B2_02910	COG1609	Transcriptional regulator
VV208B2_02920	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
VV208B2_02940	COG0281	malic enzyme
VV208B2_02950	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
VV208B2_02960	COG0626	cystathionine gamma-synthase activity
VV208B2_02970	COG0460	homoserine dehydrogenase
VV208B2_02970	COG0527	aspartate kinase activity
VV208B2_02980	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
VV208B2_03000	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
VV208B2_03040	COG0137	argininosuccinate synthase activity
VV208B2_03050	COG0165	Argininosuccinate lyase
VV208B2_03050	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
VV208B2_03070	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
VV208B2_03130	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
VV208B2_03140	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
VV208B2_03160	COG0338	D12 class N6 adenine-specific DNA methyltransferase
VV208B2_03170	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
VV208B2_03180	COG0360	Binds together with S18 to 16S ribosomal RNA
VV208B2_03200	COG0359	binds to the 23S rRNA
VV208B2_03230	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
VV208B2_03250	COG0432	Pfam Uncharacterised protein family UPF0047
VV208B2_03330	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
VV208B2_03380	COG1410	methionine synthase
VV208B2_03380	COG0646	methionine synthase
VV208B2_03390	COG0527	aspartate kinase activity
VV208B2_03400	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
VV208B2_03420	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
VV208B2_03460	COG2200	EAL domain
VV208B2_03460	COG2199	diguanylate cyclase activity
VV208B2_03510	COG3409	Peptidoglycan-binding domain 1 protein
VV208B2_03510	COG3267	Type II secretory pathway component ExeA
VV208B2_03530	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
VV208B2_03540	COG1459	type II secretion system
VV208B2_03560	COG2165	general secretion pathway protein
VV208B2_03570	COG2165	general secretion pathway protein
VV208B2_03630	COG1077	Cell shape determining protein MreB Mrl
VV208B2_03640	COG1792	Involved in formation and maintenance of cell shape
VV208B2_03650	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
VV208B2_03660	COG0424	maF-like protein
VV208B2_03680	COG3164	Protein of unknown function
VV208B2_03690	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
VV208B2_03700	COG0312	modulator of DNA gyrase
VV208B2_03710	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
VV208B2_03740	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
VV208B2_03750	COG0251	oxidation-reduction process
VV208B2_03760	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
VV208B2_03820	COG0456	acetyltransferase
VV208B2_03840	COG0525	valine-tRNA ligase activity
VV208B2_03850	COG2927	DNA polymerase III (CHI subunit)
VV208B2_03860	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
VV208B2_03870	COG0795	lipopolysaccharide-transporting ATPase activity
VV208B2_03880	COG0795	lipopolysaccharide-transporting ATPase activity
VV208B2_03900	COG4974	Belongs to the 'phage' integrase family
VV208B2_03930	COG1802	Transcriptional regulator
VV208B2_03930	COG4626	Terminase
VV208B2_03970	COG3867	Arabinogalactan endo-beta-1,4-galactanase
VV208B2_03980	COG1609	Transcriptional regulator
VV208B2_04000	COG2182	Extracellular solute-binding protein
VV208B2_04010	COG1175	transmembrane transport
VV208B2_04020	COG3833	ABC-type maltose transport systems, permease component
VV208B2_04040	COG1874	Beta-galactosidase
VV208B2_04050	COG4580	involved in the transport of maltose and maltodextrins
VV208B2_04060	COG0840	transmembrane signaling receptor activity
VV208B2_04070	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
VV208B2_04080	COG1085	galactose-1-phosphate uridylyltransferase
VV208B2_04100	COG2017	converts alpha-aldose to the beta-anomer
VV208B2_04280	COG3706	GGDEF domain
VV208B2_04300	COG2200	EAL domain
VV208B2_04320	COG0726	polysaccharide deacetylase
VV208B2_04330	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
VV208B2_04350	COG1447	Phosphotransferase system cellobiose-specific component IIA
VV208B2_04360	COG1486	melibiose metabolic process
VV208B2_04380	COG1609	Transcriptional regulator
VV208B2_04400	COG3437	response regulator, receiver
VV208B2_04440	COG0741	lytic transglycosylase activity
VV208B2_04450	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
VV208B2_04470	COG0220	tRNA (guanine-N7-)-methyltransferase activity
VV208B2_04480	COG2066	Belongs to the glutaminase family
VV208B2_04500	COG0635	Involved in the biosynthesis of porphyrin-containing compound
VV208B2_04510	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
VV208B2_04530	COG1872	DUF167
VV208B2_04540	COG0762	integral membrane protein
VV208B2_04550	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
VV208B2_04560	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
VV208B2_04590	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
VV208B2_04600	COG1678	Uncharacterized ACR, COG1678
VV208B2_04620	COG1385	rRNA (uridine-N3-)-methyltransferase activity
VV208B2_04640	COG2356	endonuclease I
VV208B2_04670	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
VV208B2_04710	COG0126	phosphoglycerate kinase activity
VV208B2_04720	COG0191	fructose-bisphosphate aldolase activity
VV208B2_04730	COG0668	transmembrane transport
VV208B2_04740	COG1279	arginine transmembrane transporter activity
VV208B2_04770	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
VV208B2_04780	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
VV208B2_04790	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
VV208B2_04800	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
VV208B2_04820	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VV208B2_04830	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VV208B2_04860	COG0354	folic acid binding
VV208B2_04880	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
VV208B2_04890	COG1595	DNA-templated transcription, initiation
VV208B2_04920	COG3086	response to oxidative stress
VV208B2_04930	COG0481	GTPase activity
VV208B2_04950	COG0571	ribonuclease III activity
VV208B2_04960	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
VV208B2_04970	COG1381	Involved in DNA repair and RecF pathway recombination
VV208B2_04980	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
VV208B2_05030	COG2205	protein histidine kinase activity
VV208B2_05030	COG3850	Histidine kinase
VV208B2_05030	COG4999	Histidine kinase
VV208B2_05030	COG3437	response regulator, receiver
VV208B2_05040	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
VV208B2_05050	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
VV208B2_05060	COG3956	TIGRFAM MazG family protein
VV208B2_05070	COG0504	CTP synthase activity
VV208B2_05080	COG0148	phosphopyruvate hydratase activity
VV208B2_05090	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
VV208B2_05100	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
VV208B2_05110	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
VV208B2_05140	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
VV208B2_05150	COG4942	peptidase
VV208B2_05150	COG1388	LysM domain
VV208B2_05160	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
VV208B2_05170	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
VV208B2_05190	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
VV208B2_05210	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
VV208B2_05220	COG0527	aspartate kinase activity
VV208B2_05230	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
VV208B2_05240	COG3630	sodium ion export across plasma membrane
VV208B2_05250	COG0511	ligase activity, forming carbon-carbon bonds
VV208B2_05250	COG5016	pyruvate
VV208B2_05260	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
VV208B2_05280	COG1238	metal cluster binding
VV208B2_05290	COG0612	Peptidase, M16
VV208B2_05300	COG2918	glutathione biosynthetic process
VV208B2_05320	COG1854	S-ribosylhomocysteine lyase activity
VV208B2_05330	COG4536	flavin adenine dinucleotide binding
VV208B2_05340	COG4137	Cytochrome C assembly protein
VV208B2_05350	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
VV208B2_05360	COG0228	four-way junction DNA binding
VV208B2_05370	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
VV208B2_05380	COG0336	Belongs to the RNA methyltransferase TrmD family
VV208B2_05390	COG0335	large ribosomal subunit rRNA binding
VV208B2_05400	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
VV208B2_05440	COG1459	type II secretion system
VV208B2_05450	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
VV208B2_05480	COG3023	N-Acetylmuramoyl-L-alanine amidase
VV208B2_05490	COG2186	Transcriptional regulator
VV208B2_05500	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
VV208B2_05510	COG0508	dehydrogenase complex catalyzes the overall conversion of
VV208B2_05520	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VV208B2_05550	COG0288	reversible hydration of carbon dioxide
VV208B2_05560	COG0659	secondary active sulfate transmembrane transporter activity
VV208B2_05570	COG1131	(ABC) transporter
VV208B2_05580	COG0842	Transport permease protein
VV208B2_05600	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
VV208B2_05610	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
VV208B2_05630	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
VV208B2_05640	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
VV208B2_05660	COG1643	Atp-dependent helicase
VV208B2_05670	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
VV208B2_05680	COG1752	Esterase of the alpha-beta hydrolase superfamily
VV208B2_05690	COG1049	propionate catabolic process, 2-methylcitrate cycle
VV208B2_05700	COG1929	Belongs to the glycerate kinase type-1 family
VV208B2_05710	COG2610	gluconate transmembrane transporter activity
VV208B2_05720	COG3835	regulator
VV208B2_05730	COG3112	Uncharacterised protein family (UPF0231)
VV208B2_05740	COG0347	Belongs to the P(II) protein family
VV208B2_05750	COG0004	ammonium transporteR
VV208B2_05760	COG1840	ABC-type Fe3 transport system, periplasmic component
VV208B2_05790	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
VV208B2_05820	COG2971	BadF BadG BcrA BcrD
VV208B2_05840	COG4608	Belongs to the ABC transporter superfamily
VV208B2_05850	COG0444	Belongs to the ABC transporter superfamily
VV208B2_05860	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VV208B2_05870	COG0601	transmembrane transport
VV208B2_05890	COG0784	Response regulator, receiver
VV208B2_05890	COG2205	protein histidine kinase activity
VV208B2_05900	COG2813	Specifically methylates the guanine in position
VV208B2_05910	COG0628	permease
VV208B2_05930	COG0316	Belongs to the HesB IscA family
VV208B2_05960	COG0739	heme binding
VV208B2_05970	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
VV208B2_05980	COG2832	Protein of unknown function (DUF454)
VV208B2_05990	COG2027	D-alanyl-D-alanine carboxypeptidase
VV208B2_06020	COG1534	Rna-binding protein
VV208B2_06030	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
VV208B2_06040	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
VV208B2_06050	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
VV208B2_06060	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
VV208B2_06070	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
VV208B2_06080	COG0779	Required for maturation of 30S ribosomal subunits
VV208B2_06090	COG0195	Participates in both transcription termination and antitermination
VV208B2_06100	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
VV208B2_06110	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
VV208B2_06120	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
VV208B2_06130	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
VV208B2_06190	COG1185	polyribonucleotide nucleotidyltransferase activity
VV208B2_06220	COG0534	Mate efflux family protein
VV208B2_06230	COG0826	peptidase U32
VV208B2_06240	COG0826	peptidase U32
VV208B2_06260	COG3154	lipid carrier protein
VV208B2_06270	COG3153	acetyltransferase
VV208B2_06290	COG0456	acetyltransferase
VV208B2_06310	COG3706	GGDEF domain
VV208B2_06330	COG0084	hydrolase, TatD family'
VV208B2_06340	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
VV208B2_06350	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
VV208B2_06360	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
VV208B2_06370	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
VV208B2_06380	COG0813	purine-nucleoside phosphorylase activity
VV208B2_06400	COG0560	Phosphoserine phosphatase
VV208B2_06420	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
VV208B2_06430	COG3447	MASE1 domain protein
VV208B2_06430	COG5001	Diguanylate cyclase
VV208B2_06430	COG5002	protein histidine kinase activity
VV208B2_06460	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
VV208B2_06470	COG0583	DNA-binding transcription factor activity
VV208B2_06490	COG1022	Amp-dependent synthetase and ligase
VV208B2_06560	COG4964	Belongs to the GSP D family
VV208B2_06660	COG2059	Chromate
VV208B2_06670	COG0583	DNA-binding transcription factor activity
VV208B2_06700	COG3408	Glycogen debranching enzyme
VV208B2_06700	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
VV208B2_06710	COG0531	amino acid
VV208B2_06720	COG0531	amino acid
VV208B2_06730	COG2731	YhcH YjgK YiaL family protein
VV208B2_06740	COG3250	beta-galactosidase activity
VV208B2_06760	COG1609	Transcriptional regulator
VV208B2_06770	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
VV208B2_06800	COG2017	converts alpha-aldose to the beta-anomer
VV208B2_06810	COG0840	transmembrane signaling receptor activity
VV208B2_06830	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VV208B2_06860	COG0189	ligase activity
VV208B2_06860	COG0569	domain protein
VV208B2_06890	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
VV208B2_06910	COG1349	DNA-binding transcription factor activity
VV208B2_06920	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
VV208B2_06930	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
VV208B2_06940	COG2171	N-acyltransferase activity
VV208B2_06950	COG3141	response to X-ray
VV208B2_06980	COG3083	sulfuric ester hydrolase activity
VV208B2_06990	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
VV208B2_07000	COG1074	ATP-dependent DNA helicase activity
VV208B2_07010	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
VV208B2_07050	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
VV208B2_07060	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
VV208B2_07070	COG2166	iron-sulfur cluster assembly
VV208B2_07080	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
VV208B2_07090	COG0693	protein deglycase activity
VV208B2_07100	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
VV208B2_07130	COG1595	DNA-templated transcription, initiation
VV208B2_07150	COG2211	Major facilitator Superfamily
VV208B2_07180	COG2813	Specifically methylates the guanine in position
VV208B2_07190	COG0271	Belongs to the BolA IbaG family
VV208B2_07200	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
VV208B2_07210	COG1805	sodium ion transport
VV208B2_07220	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
VV208B2_07240	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
VV208B2_07250	COG2871	sodium ion transport
VV208B2_07260	COG1477	protein flavinylation
VV208B2_07290	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
VV208B2_07300	COG0514	ATP-dependent DNA helicase (RecQ)
VV208B2_07330	COG0733	neurotransmitter:sodium symporter activity
VV208B2_07370	COG0442	prolyl-tRNA aminoacylation
VV208B2_07380	COG1720	tRNA m6t6A37 methyltransferase activity
VV208B2_07390	COG0254	rRNA binding
VV208B2_07400	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
VV208B2_07430	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
VV208B2_07500	COG3098	single-species biofilm formation
VV208B2_07530	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
VV208B2_07540	COG0024	Methionine aminopeptidase
VV208B2_07550	COG0052	Belongs to the universal ribosomal protein uS2 family
VV208B2_07560	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
VV208B2_07570	COG0528	UMP kinase activity
VV208B2_07580	COG0233	cytoplasmic translational termination
VV208B2_07590	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
VV208B2_07600	COG0575	Belongs to the CDS family
VV208B2_07610	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
VV208B2_07620	COG0750	zinc metalloprotease
VV208B2_07630	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VV208B2_07640	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
VV208B2_07650	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VV208B2_07660	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
VV208B2_07670	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VV208B2_07680	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VV208B2_07690	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
VV208B2_07700	COG0587	DNA-directed DNA polymerase activity
VV208B2_07710	COG0825	malonyl-CoA metabolic process
VV208B2_07740	COG0347	Belongs to the P(II) protein family
VV208B2_07770	COG0741	lytic transglycosylase activity
VV208B2_07770	COG1388	LysM domain
VV208B2_07780	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
VV208B2_07790	COG2226	methyltransferase
VV208B2_07800	COG0328	RNA-DNA hybrid ribonuclease activity
VV208B2_07830	COG2249	NAD(P)H dehydrogenase (quinone) activity
VV208B2_07890	COG1960	acyl-CoA dehydrogenase activity
VV208B2_07910	COG0121	glutamine amidotransferase
VV208B2_07920	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
VV208B2_07930	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
VV208B2_07940	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
VV208B2_07950	COG2233	PERMEase
VV208B2_07990	COG1393	Belongs to the ArsC family
VV208B2_08000	COG4783	chaperone-mediated protein folding
VV208B2_08030	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
VV208B2_08040	COG2716	regulation of RNA biosynthetic process
VV208B2_08050	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
VV208B2_08060	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
VV208B2_08100	COG1393	Belongs to the ArsC family
VV208B2_08150	COG2837	iron assimilation
VV208B2_08160	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VV208B2_08170	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VV208B2_08180	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VV208B2_08190	COG1334	flagellar protein FlaG
VV208B2_08200	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
VV208B2_08220	COG1516	flagellar protein fliS
VV208B2_08260	COG1677	Flagellar hook-basal body complex protein FliE
VV208B2_08280	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
VV208B2_08380	COG1987	bacterial-type flagellum assembly
VV208B2_08390	COG1684	flagellar biosynthetic protein fliR
VV208B2_08460	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
VV208B2_08470	COG0643	Histidine kinase
VV208B2_08470	COG0784	Response regulator, receiver
VV208B2_08470	COG2198	Histidine kinase
VV208B2_08480	COG2201	protein-glutamate methylesterase activity
VV208B2_08490	COG1192	Involved in chromosome partitioning
VV208B2_08510	COG0835	chemotaxis
VV208B2_08530	COG4133	protoheme IX ABC transporter activity
VV208B2_08540	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
VV208B2_08550	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
VV208B2_08560	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
VV208B2_08570	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
VV208B2_08580	COG1138	Cytochrome C-type biogenesis protein
VV208B2_08590	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
VV208B2_08600	COG4235	cytochrome complex assembly
VV208B2_08600	COG3088	subunit of a heme lyase
VV208B2_08620	COG2853	Lipoprotein
VV208B2_08630	COG2067	long-chain fatty acid transport protein
VV208B2_08640	COG2067	long-chain fatty acid transport protein
VV208B2_08670	COG0183	Belongs to the thiolase family
VV208B2_08680	COG1024	Enoyl-CoA hydratase
VV208B2_08680	COG1250	3-hydroxyacyl-CoA dehydrogenase
VV208B2_08700	COG1025	Belongs to the peptidase M16 family
VV208B2_08710	COG2062	phosphohistidine phosphatase, SixA
VV208B2_08720	COG2840	Smr protein MutS2
VV208B2_08730	COG2890	protein-(glutamine-N5) methyltransferase activity
VV208B2_08740	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
VV208B2_08750	COG2860	membrane
VV208B2_08760	COG3101	peptidyl-lysine hydroxylation
VV208B2_08780	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
VV208B2_08780	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
VV208B2_08790	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
VV208B2_08810	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
VV208B2_08830	COG0101	tRNA pseudouridine synthase activity
VV208B2_08840	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
VV208B2_08850	COG0285	dihydrofolate synthase activity
VV208B2_08860	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
VV208B2_08870	COG1286	toxin biosynthetic process
VV208B2_08880	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
VV208B2_08890	COG0583	DNA-binding transcription factor activity
VV208B2_08900	COG0745	RESPONSE REGULATOR receiver
VV208B2_08920	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
VV208B2_08940	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
VV208B2_08950	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
VV208B2_08980	COG2205	protein histidine kinase activity
VV208B2_08990	COG0745	RESPONSE REGULATOR receiver
VV208B2_09020	COG2983	Belongs to the UPF0260 family
VV208B2_09040	COG0346	lactoylglutathione lyase activity
VV208B2_09060	COG1785	Belongs to the alkaline phosphatase family
VV208B2_09090	COG2226	methyltransferase
VV208B2_09100	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
VV208B2_09110	COG2239	Acts as a magnesium transporter
VV208B2_09120	COG2203	Gaf domain
VV208B2_09120	COG2199	diguanylate cyclase activity
VV208B2_09160	COG3710	Transcriptional regulator
VV208B2_09180	COG0531	amino acid
VV208B2_09190	COG1982	Orn Lys Arg decarboxylase major
VV208B2_09200	COG3706	GGDEF domain
VV208B2_09210	COG0517	IMP dehydrogenase activity
VV208B2_09210	COG0617	tRNA 3'-terminal CCA addition
VV208B2_09210	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
VV208B2_09260	COG0537	adenosine 5'-monophosphoramidase activity
VV208B2_09320	COG1252	NADH dehydrogenase
VV208B2_09350	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
VV208B2_09370	COG4591	ABC-type transport system involved in lipoprotein release permease component
VV208B2_09380	COG1136	(ABC) transporter
VV208B2_09390	COG4591	ABC-type transport system involved in lipoprotein release permease component
VV208B2_09410	COG0658	competence protein
VV208B2_09410	COG2333	competence protein COMEC
VV208B2_09420	COG1132	(ABC) transporter
VV208B2_09430	COG1663	tetraacyldisaccharide 4'-kinase activity
VV208B2_09440	COG2835	tetraacyldisaccharide 4'-kinase activity
VV208B2_09450	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
VV208B2_09460	COG2199	diguanylate cyclase activity
VV208B2_09470	COG2719	SpoVR family
VV208B2_09480	COG2718	Belongs to the UPF0229 family
VV208B2_09490	COG2766	serine protein kinase
VV208B2_09500	COG3013	Belongs to the UPF0304 family
VV208B2_09520	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
VV208B2_09550	COG1882	Formate acetyltransferase
VV208B2_09630	COG0708	Exodeoxyribonuclease III
VV208B2_09640	COG0840	transmembrane signaling receptor activity
VV208B2_09660	COG3923	Primosomal replication protein n
VV208B2_09680	COG1199	ATP-dependent helicase activity
VV208B2_09730	COG1278	Cold shock
VV208B2_09740	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
VV208B2_09750	COG0542	response to heat
VV208B2_09760	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
VV208B2_09800	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
VV208B2_09820	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
VV208B2_09830	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
VV208B2_09840	COG0297	glycogen (starch) synthase activity
VV208B2_09880	COG3070	regulator of competence-specific genes
VV208B2_09890	COG1609	Transcriptional regulator
VV208B2_09900	COG3381	protein complex oligomerization
VV208B2_09910	COG0745	RESPONSE REGULATOR receiver
VV208B2_09920	COG1434	Gram-negative-bacterium-type cell wall biogenesis
VV208B2_09930	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
VV208B2_09940	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
VV208B2_09950	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
VV208B2_09960	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
VV208B2_10020	COG4067	protein conserved in archaea
VV208B2_10020	COG0189	ligase activity
VV208B2_10030	COG0500	methyltransferase
VV208B2_10040	COG4106	trans-aconitate 2-methyltransferase activity
VV208B2_10080	COG0840	transmembrane signaling receptor activity
VV208B2_10090	COG0632	four-way junction helicase activity
VV208B2_10100	COG2255	four-way junction helicase activity
VV208B2_10110	COG1271	oxidase subunit
VV208B2_10120	COG1294	oxidase, subunit
VV208B2_10140	COG0824	Thioesterase
VV208B2_10150	COG0811	peptide transport
VV208B2_10180	COG0823	Involved in the tonB-independent uptake of proteins
VV208B2_10190	COG2885	chlorophyll binding
VV208B2_10200	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
VV208B2_10210	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
VV208B2_10230	COG3766	membrane
VV208B2_10250	COG0754	glutathionylspermidine amidase activity
VV208B2_10270	COG2205	protein histidine kinase activity
VV208B2_10270	COG0784	Response regulator, receiver
VV208B2_10340	COG2801	Transposase and inactivated derivatives
VV208B2_10370	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
VV208B2_10380	COG4804	nuclease activity
VV208B2_10390	COG0732	type I restriction modification DNA specificity domain
VV208B2_10410	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
VV208B2_10440	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
VV208B2_10470	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
VV208B2_10480	COG0840	transmembrane signaling receptor activity
VV208B2_10500	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
VV208B2_10510	COG0861	Integral membrane protein TerC family
VV208B2_10560	COG2207	Transcriptional regulator
VV208B2_10600	COG1032	radical SAM domain protein
VV208B2_10650	COG0583	DNA-binding transcription factor activity
VV208B2_10670	COG0857	belongs to the CobB CobQ family
VV208B2_10670	COG0280	phosphate acetyltransferase
VV208B2_10680	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
VV208B2_10690	COG3092	negative regulation of chromosome organization
VV208B2_10710	COG4120	Belongs to the binding-protein-dependent transport system permease family
VV208B2_10730	COG0366	Alpha amylase catalytic
VV208B2_10760	COG0653	protein targeting
VV208B2_10780	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
VV208B2_10790	COG2186	Transcriptional regulator
VV208B2_10820	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
VV208B2_10870	COG1846	Transcriptional regulator
VV208B2_10880	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
VV208B2_10890	COG0840	transmembrane signaling receptor activity
VV208B2_10930	COG1448	Aminotransferase
VV208B2_10940	COG3437	response regulator, receiver
VV208B2_10940	COG2770	Histidine kinase
VV208B2_10970	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
VV208B2_10990	COG0017	Asparaginyl-tRNA synthetase
VV208B2_11000	COG0840	transmembrane signaling receptor activity
VV208B2_11010	COG0720	synthase
VV208B2_11030	COG2200	EAL domain
VV208B2_11040	COG1760	l-serine dehydratase
VV208B2_11050	COG0814	amino acid
VV208B2_11060	COG0494	nUDIX hydrolase
VV208B2_11080	COG2205	protein histidine kinase activity
VV208B2_11080	COG0784	Response regulator, receiver
VV208B2_11100	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
VV208B2_11130	COG3106	COG3106 Predicted ATPase
VV208B2_11140	COG3768	UPF0283 membrane protein
VV208B2_11150	COG3283	Transcriptional regulator of aromatic amino acids metabolism
VV208B2_11160	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VV208B2_11190	COG0471	metal ion transport
VV208B2_11200	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VV208B2_11200	COG4191	Histidine kinase
VV208B2_11220	COG3706	GGDEF domain
VV208B2_11230	COG2200	EAL domain
VV208B2_11230	COG2199	diguanylate cyclase activity
VV208B2_11260	COG5001	Diguanylate cyclase
VV208B2_11260	COG3300	MHYT domain
VV208B2_11270	COG1328	CTP reductase activity
VV208B2_11280	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
VV208B2_11290	COG0583	DNA-binding transcription factor activity
VV208B2_11320	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
VV208B2_11330	COG4667	esterase of the alpha-beta hydrolase superfamily
VV208B2_11350	COG1597	lipid kinase activity
VV208B2_11360	COG0814	amino acid
VV208B2_11390	COG0783	Belongs to the Dps family
VV208B2_11420	COG1132	(ABC) transporter
VV208B2_11430	COG1132	(ABC) transporter
VV208B2_11440	COG1115	amino acid carrier protein
VV208B2_11470	COG1596	polysaccharide export
VV208B2_11520	COG0438	transferase activity, transferring glycosyl groups
VV208B2_11530	COG0297	glycogen (starch) synthase activity
VV208B2_11530	COG0438	transferase activity, transferring glycosyl groups
VV208B2_11560	COG2165	general secretion pathway protein
VV208B2_11610	COG0443	Heat shock 70 kDa protein
VV208B2_11620	COG0443	Heat shock 70 kDa protein
VV208B2_11640	COG3706	GGDEF domain
VV208B2_11680	COG3713	MltA-interacting MipA family protein
VV208B2_11740	COG4964	Belongs to the GSP D family
VV208B2_11760	COG2894	cell division
VV208B2_11840	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
VV208B2_11860	COG1643	Atp-dependent helicase
VV208B2_11910	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
VV208B2_11930	COG2814	Major facilitator Superfamily
VV208B2_11960	COG0840	transmembrane signaling receptor activity
VV208B2_11970	COG0010	Belongs to the arginase family
VV208B2_11980	COG1166	arginine decarboxylase activity
VV208B2_12110	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
VV208B2_12120	COG0072	phenylalanine-tRNA ligase activity
VV208B2_12120	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VV208B2_12160	COG0776	regulation of translation
VV208B2_12180	COG0500	methyltransferase
VV208B2_12190	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
VV208B2_12200	COG0295	cytidine deaminase activity
VV208B2_12240	COG2885	chlorophyll binding
VV208B2_12270	COG0277	FAD linked oxidase domain protein
VV208B2_12270	COG0247	lactate metabolic process
VV208B2_12280	COG2020	methyltransferase activity
VV208B2_12290	COG5640	endopeptidase activity
VV208B2_12310	COG2986	histidine ammonia-lyase
VV208B2_12330	COG0010	Belongs to the arginase family
VV208B2_12340	COG1228	amidohydrolase
VV208B2_12360	COG4326	sporulation control protein
VV208B2_12400	COG0291	Belongs to the bacterial ribosomal protein bL35 family
VV208B2_12440	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VV208B2_12460	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VV208B2_12490	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VV208B2_12730	COG2026	Addiction module toxin, RelE StbE family
VV208B2_12920	COG0625	glutathione transferase activity
VV208B2_12980	COG4628	conserved protein (DUF2132)
VV208B2_13310	COG1028	Short-chain dehydrogenase reductase Sdr
VV208B2_13410	COG0534	Mate efflux family protein
VV208B2_13420	COG0307	riboflavin synthase, alpha
VV208B2_13460	COG3706	GGDEF domain
VV208B2_13480	COG0791	NLP P60 protein
VV208B2_13490	COG0840	transmembrane signaling receptor activity
VV208B2_13510	COG3148	PFAM DTW domain containing protein
VV208B2_13520	COG1940	carbohydrate kinase activity
VV208B2_13550	COG0746	molybdenum cofactor guanylyltransferase activity
VV208B2_13560	COG3842	ATPase activity
VV208B2_13570	COG4662	Binding-protein-dependent transport system inner membrane component
VV208B2_13590	COG2204	response regulator
VV208B2_13600	COG3852	Histidine kinase
VV208B2_13630	COG0488	(ABC) transporter
VV208B2_13650	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
VV208B2_13710	COG0243	molybdopterin cofactor binding
VV208B2_13710	COG3383	formate dehydrogenase (NAD+) activity
VV208B2_13720	COG0437	4 iron, 4 sulfur cluster binding
VV208B2_13780	COG0004	ammonium transporteR
VV208B2_13790	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
VV208B2_13800	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
VV208B2_13820	COG1177	transmembrane transport
VV208B2_13830	COG1176	ABC-type spermidine putrescine transport system, permease component I
VV208B2_13840	COG3842	ATPase activity
VV208B2_13860	COG2992	FlgJ-related protein
VV208B2_13880	COG0037	tRNA processing
VV208B2_13890	COG0589	response to stress
VV208B2_13900	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VV208B2_13930	COG2217	Heavy metal translocating P-type atpase
VV208B2_13950	COG2010	Cytochrome c
VV208B2_13980	COG3278	Belongs to the heme-copper respiratory oxidase family
VV208B2_14010	COG0784	Response regulator, receiver
VV208B2_14010	COG2205	protein histidine kinase activity
VV208B2_14110	COG1450	Type ii and iii secretion system protein
VV208B2_14170	COG3120	sequence-specific DNA binding
VV208B2_14180	COG1067	ATP-dependent peptidase activity
VV208B2_14190	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
VV208B2_14220	COG0488	(ABC) transporter
VV208B2_14240	COG0116	Belongs to the methyltransferase superfamily
VV208B2_14240	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
VV208B2_14270	COG2902	Dehydrogenase
VV208B2_14290	COG0308	aminopeptidase N
VV208B2_14320	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
VV208B2_14330	COG1956	GAF domain-containing protein
VV208B2_14340	COG1132	(ABC) transporter
VV208B2_14350	COG2995	paraquat-inducible protein a
VV208B2_14360	COG3008	intermembrane lipid transfer
VV208B2_14370	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
VV208B2_14370	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
VV208B2_14380	COG2996	Protein conserved in bacteria
VV208B2_14410	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
VV208B2_14430	COG3706	GGDEF domain
VV208B2_14440	COG1793	dna ligase
VV208B2_14450	COG1366	Belongs to the anti-sigma-factor antagonist family
VV208B2_14510	COG2204	response regulator
VV208B2_14600	COG0438	transferase activity, transferring glycosyl groups
VV208B2_14620	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
VV208B2_14690	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
VV208B2_14700	COG0363	glucosamine-6-phosphate deaminase activity
VV208B2_14710	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
VV208B2_14720	COG4565	transcriptional regulatory protein
VV208B2_14730	COG3290	protein histidine kinase activity
VV208B2_14760	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VV208B2_14820	COG1115	amino acid carrier protein
VV208B2_14850	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
VV208B2_14860	COG0204	Acyl-transferase
VV208B2_14870	COG0348	domain, Protein
VV208B2_14880	COG0437	4 iron, 4 sulfur cluster binding
VV208B2_14900	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VV208B2_14910	COG4597	amino acid ABC transporter
VV208B2_14920	COG0765	amino acid transport
VV208B2_14930	COG1126	abc transporter atp-binding protein
VV208B2_14940	COG0670	Belongs to the BI1 family
VV208B2_14960	COG2920	part of a sulfur-relay system
VV208B2_14970	COG1254	Belongs to the acylphosphatase family
VV208B2_14990	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
VV208B2_15040	COG3706	GGDEF domain
VV208B2_15050	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
VV208B2_15060	COG0602	queuosine metabolic process
VV208B2_15070	COG0561	phosphatase activity
VV208B2_15140	COG2828	Protein conserved in bacteria
VV208B2_15150	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
VV208B2_15160	COG0372	Belongs to the citrate synthase family
VV208B2_15170	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
VV208B2_15190	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
VV208B2_15280	COG2197	response regulator
VV208B2_15300	COG0730	response to heat
VV208B2_15330	COG1653	transport
VV208B2_15340	COG1175	transmembrane transport
VV208B2_15350	COG0395	ABC-type sugar transport system, permease component
VV208B2_15370	COG1349	DNA-binding transcription factor activity
VV208B2_15380	COG0584	glycerophosphoryl diester phosphodiesterase
VV208B2_15400	COG1278	Cold shock
VV208B2_15460	COG0625	glutathione transferase activity
VV208B2_15480	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
VV208B2_15500	COG2195	Cleaves the N-terminal amino acid of tripeptides
VV208B2_15510	COG0737	Belongs to the 5'-nucleotidase family
VV208B2_15530	COG3063	Type IV pilus biogenesis stability protein PilW
VV208B2_15560	COG1451	nucleotide metabolic process
VV208B2_15630	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
VV208B2_15690	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
VV208B2_15720	COG2925	Exonuclease
VV208B2_15730	COG1380	Effector of murein hydrolase LrgA
VV208B2_15740	COG1346	cytolysis
VV208B2_15760	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
VV208B2_15790	COG1643	Atp-dependent helicase
VV208B2_15800	COG0281	malic enzyme
VV208B2_15810	COG2949	membrane
VV208B2_15820	COG0471	metal ion transport
VV208B2_15850	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
VV208B2_15870	COG0492	ferredoxin-NADP+ reductase activity
VV208B2_15880	COG4988	ABC transporter
VV208B2_15890	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
VV208B2_15900	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
VV208B2_15920	COG5002	protein histidine kinase activity
VV208B2_15950	COG3070	regulator of competence-specific genes
VV208B2_15970	COG2431	L-lysine efflux transmembrane transporter activity
VV208B2_15990	COG0076	glutamate decarboxylase activity
VV208B2_16000	COG1737	Transcriptional regulator
VV208B2_16010	COG1979	alcohol dehydrogenase
VV208B2_16020	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
VV208B2_16030	COG2985	domain, Protein
VV208B2_16030	COG3273	potassium ion transport
VV208B2_16040	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
VV208B2_16070	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
VV208B2_16100	COG1136	(ABC) transporter
VV208B2_16110	COG0702	epimerase
VV208B2_16140	COG2814	Major facilitator Superfamily
VV208B2_16160	COG1061	Type III restriction enzyme res subunit
VV208B2_16190	COG2205	protein histidine kinase activity
VV208B2_16200	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
VV208B2_16250	COG3313	Fe-S protein
VV208B2_16270	COG4134	Bacterial extracellular solute-binding protein
VV208B2_16280	COG4135	transport system, permease component
VV208B2_16290	COG4136	ATPase activity
VV208B2_16300	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
VV208B2_16310	COG3604	Transcriptional regulator
VV208B2_16320	COG1151	hydroxylamine reductase activity
VV208B2_16330	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
VV208B2_16350	COG0564	pseudouridine synthase activity
VV208B2_16380	COG0733	neurotransmitter:sodium symporter activity
VV208B2_16400	COG0626	cystathionine gamma-synthase activity
VV208B2_16410	COG2818	Glycosylase
VV208B2_16430	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VV208B2_16450	COG1983	PspC domain protein
VV208B2_16470	COG1842	Phage shock protein A
VV208B2_16480	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
VV208B2_16530	COG4172	Belongs to the ABC transporter superfamily
VV208B2_16560	COG1227	inorganic diphosphatase activity
VV208B2_16640	COG3005	denitrification pathway
VV208B2_16650	COG0390	transport system, permease component
VV208B2_16660	COG2116	formate transmembrane transporter activity
VV208B2_16700	COG0583	DNA-binding transcription factor activity
VV208B2_16710	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
VV208B2_16730	COG1435	thymidine kinase activity
VV208B2_16740	COG0215	cysteine-tRNA ligase activity
VV208B2_16750	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
VV208B2_16760	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VV208B2_16770	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
VV208B2_16780	COG3012	SEC-C Motif Domain Protein
VV208B2_16790	COG0140	phosphoribosyl-ATP diphosphatase activity
VV208B2_16790	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
VV208B2_16810	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
VV208B2_16820	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
VV208B2_16830	COG0131	Imidazoleglycerol-phosphate dehydratase
VV208B2_16830	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
VV208B2_16840	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
VV208B2_16860	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
VV208B2_16870	COG1757	Na H antiporter
VV208B2_16880	COG2916	Histone family protein nucleoid-structuring protein H-NS
VV208B2_16890	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VV208B2_16920	COG2915	High frequency lysogenization protein hflD homolog
VV208B2_16930	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
VV208B2_16970	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
VV208B2_17010	COG0300	oxidoreductase activity
VV208B2_17030	COG0501	Belongs to the peptidase M48B family
VV208B2_17050	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
VV208B2_17070	COG0156	8-amino-7-oxononanoate synthase activity
VV208B2_17080	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
VV208B2_17110	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
VV208B2_17120	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
VV208B2_17150	COG0686	Belongs to the AlaDH PNT family
VV208B2_17170	COG0583	DNA-binding transcription factor activity
VV208B2_17230	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
VV208B2_17240	COG3108	Peptidase M15
VV208B2_17250	COG2989	Protein conserved in bacteria
VV208B2_17330	COG4608	Belongs to the ABC transporter superfamily
VV208B2_17340	COG0444	Belongs to the ABC transporter superfamily
VV208B2_17350	COG4166	transmembrane transport
VV208B2_17360	COG4239	(ABC) transporter, permease
VV208B2_17370	COG4174	ABC transporter (Permease)
VV208B2_17390	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
VV208B2_17400	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
VV208B2_17420	COG0539	negative regulation of cytoplasmic translation
VV208B2_17440	COG0616	signal peptide processing
VV208B2_17450	COG1028	Short-chain dehydrogenase reductase Sdr
VV208B2_17490	COG0784	Response regulator, receiver
VV208B2_17490	COG0835	chemotaxis
VV208B2_17500	COG1940	carbohydrate kinase activity
VV208B2_17510	COG0469	pyruvate kinase activity
VV208B2_17520	COG4667	esterase of the alpha-beta hydrolase superfamily
VV208B2_17540	COG0733	neurotransmitter:sodium symporter activity
VV208B2_17560	COG1263	PTS System
VV208B2_17560	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VV208B2_17570	COG0084	hydrolase, TatD family'
VV208B2_17590	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
VV208B2_17600	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
VV208B2_17630	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
VV208B2_17660	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
VV208B2_17670	COG0416	fatty acid biosynthetic process
VV208B2_17680	COG0333	Belongs to the bacterial ribosomal protein bL32 family
VV208B2_17690	COG1399	metal-binding, possibly nucleic acid-binding protein
VV208B2_17700	COG0424	maF-like protein
VV208B2_17720	COG1530	ribonuclease E activity
VV208B2_17730	COG0659	secondary active sulfate transmembrane transporter activity
VV208B2_17740	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
VV208B2_17750	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
VV208B2_17770	COG0572	uridine kinase
VV208B2_17790	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VV208B2_17790	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VV208B2_17820	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
VV208B2_17830	COG1138	Cytochrome C-type biogenesis protein
VV208B2_17840	COG3301	Polysulphide reductase, NrfD
VV208B2_17850	COG0437	4 iron, 4 sulfur cluster binding
VV208B2_17860	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
VV208B2_17870	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
VV208B2_17910	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
VV208B2_17920	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
VV208B2_17930	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
VV208B2_18030	COG2197	response regulator
VV208B2_18040	COG0417	DNA replication proofreading
VV208B2_18050	COG5001	Diguanylate cyclase
VV208B2_18070	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
VV208B2_18080	COG3099	Belongs to the UPF0263 family
VV208B2_18110	COG0009	L-threonylcarbamoyladenylate synthase
VV208B2_18120	COG0613	PHP domain protein
VV208B2_18130	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
VV208B2_18140	COG0512	Glutamine amidotransferase of anthranilate synthase
VV208B2_18150	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
VV208B2_18160	COG0134	indole-3-glycerol-phosphate synthase activity
VV208B2_18160	COG0135	phosphoribosylanthranilate isomerase activity
VV208B2_18170	COG0133	tryptophan synthase activity
VV208B2_18180	COG0159	tryptophan synthase activity
VV208B2_18190	COG1301	dicarboxylic acid transport
VV208B2_18230	COG2350	Protein conserved in bacteria
VV208B2_18250	COG0435	Glutathione S-transferase
VV208B2_18270	COG0444	Belongs to the ABC transporter superfamily
VV208B2_18280	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VV208B2_18290	COG0601	transmembrane transport
VV208B2_18320	COG0314	molybdopterin synthase activity
VV208B2_18330	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
VV208B2_18350	COG0521	Mo-molybdopterin cofactor biosynthetic process
VV208B2_18370	COG0391	Required for morphogenesis under gluconeogenic growth conditions
VV208B2_18380	COG2198	Histidine kinase
VV208B2_18390	COG2204	response regulator
VV208B2_18400	COG0556	nucleotide-excision repair
VV208B2_18430	COG4657	Part of a membrane complex involved in electron transport
VV208B2_18440	COG2878	Part of a membrane complex involved in electron transport
VV208B2_18450	COG4656	Part of a membrane complex involved in electron transport
VV208B2_18460	COG4658	electron transport chain
VV208B2_18470	COG4659	FMN binding
VV208B2_18480	COG4660	Part of a membrane complex involved in electron transport
VV208B2_18490	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
VV208B2_18500	COG0346	lactoylglutathione lyase activity
VV208B2_18520	COG2885	chlorophyll binding
VV208B2_18550	COG2056	Na+-H+ antiporter family
VV208B2_18570	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
VV208B2_18600	COG1028	Short-chain dehydrogenase reductase Sdr
VV208B2_18610	COG1454	alcohol dehydrogenase
VV208B2_18610	COG1012	belongs to the aldehyde dehydrogenase family
VV208B2_18620	COG2095	MarC family integral membrane protein
VV208B2_18630	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VV208B2_18650	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
VV208B2_18660	COG1757	Na H antiporter
VV208B2_18690	COG3081	Nucleoid-associated protein
VV208B2_18710	COG3083	sulfuric ester hydrolase activity
VV208B2_18720	COG0569	domain protein
VV208B2_18730	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
VV208B2_18740	COG2731	YhcH YjgK YiaL family protein
VV208B2_18750	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
VV208B2_18770	COG0784	Response regulator, receiver
VV208B2_18770	COG2205	protein histidine kinase activity
VV208B2_18780	COG0123	including yeast histone deacetylase and acetoin utilization protein
VV208B2_18790	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
VV208B2_18800	COG0778	Nitroreductase
VV208B2_18810	COG1902	pentaerythritol trinitrate reductase activity
VV208B2_18810	COG0446	pyridine nucleotide-disulphide oxidoreductase
VV208B2_18820	COG0616	signal peptide processing
VV208B2_18830	COG0252	asparaginase activity
VV208B2_18840	COG3139	Protein of unknown function (DUF1315)
VV208B2_18870	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
VV208B2_18960	COG3126	Type III secretion system lipoprotein chaperone (YscW)
VV208B2_18970	COG1946	Acyl-CoA thioesterase
VV208B2_18990	COG1522	sequence-specific DNA binding
VV208B2_19000	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
VV208B2_19030	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VV208B2_19040	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VV208B2_19090	COG0318	PFAM AMP-dependent synthetase and ligase
VV208B2_19110	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
VV208B2_19140	COG1169	isochorismate synthase
VV208B2_19150	COG0436	Aminotransferase
VV208B2_19160	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
VV208B2_19170	COG0232	Belongs to the dGTPase family. Type 2 subfamily
VV208B2_19200	COG1555	photosystem II stabilization
VV208B2_19210	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
VV208B2_19220	COG0776	regulation of translation
VV208B2_19230	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
VV208B2_19240	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
VV208B2_19270	COG4191	Histidine kinase
VV208B2_19280	COG2204	response regulator
VV208B2_19300	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
VV208B2_19310	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
VV208B2_19320	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
VV208B2_19330	COG3842	ATPase activity
VV208B2_19350	COG1175	transmembrane transport
VV208B2_19390	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
VV208B2_19420	COG3385	transposase activity
VV208B2_19480	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
VV208B2_19490	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
VV208B2_19510	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
VV208B2_19530	COG1216	Glycosyl transferase, family 2
VV208B2_19540	COG2986	histidine ammonia-lyase
VV208B2_19590	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
VV208B2_19610	COG1028	Short-chain dehydrogenase reductase Sdr
VV208B2_19650	COG1695	Transcriptional regulator
VV208B2_20100	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
VV208B2_20130	COG5002	protein histidine kinase activity
VV208B2_20140	COG0745	RESPONSE REGULATOR receiver
VV208B2_20160	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
VV208B2_20180	COG2951	lytic endotransglycosylase activity
VV208B2_20200	COG0850	regulation of cytokinetic process
VV208B2_20210	COG2894	cell division
VV208B2_20220	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
VV208B2_20230	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
VV208B2_20240	COG0318	PFAM AMP-dependent synthetase and ligase
VV208B2_20250	COG0596	Alpha beta hydrolase
VV208B2_20280	COG1214	PFAM Peptidase M22, glycoprotease
VV208B2_20290	COG1199	ATP-dependent helicase activity
VV208B2_20310	COG0788	formyltetrahydrofolate deformylase activity
VV208B2_20320	COG3102	Protein conserved in bacteria
VV208B2_20360	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
VV208B2_20370	COG1918	ferrous iron import across plasma membrane
VV208B2_20390	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
VV208B2_20400	COG1121	(ABC) transporter
VV208B2_20410	COG1108	ABC-type Mn2 Zn2 transport systems permease components
VV208B2_20440	COG0508	dehydrogenase complex catalyzes the overall conversion of
VV208B2_20450	COG0567	Dehydrogenase, E1 component
VV208B2_20470	COG1053	succinate dehydrogenase
VV208B2_20480	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
VV208B2_20490	COG2009	succinate dehydrogenase
VV208B2_20510	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
VV208B2_20530	COG0446	pyridine nucleotide-disulphide oxidoreductase
VV208B2_20550	COG0251	oxidation-reduction process
VV208B2_20560	COG2964	Protein conserved in bacteria
VV208B2_20570	COG0033	Phosphoglucomutase
VV208B2_20580	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
VV208B2_20590	COG0596	Alpha beta hydrolase
VV208B2_20610	COG0716	FMN binding
VV208B2_20640	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
VV208B2_20650	COG1263	PTS System
VV208B2_20650	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VV208B2_20650	COG2190	(PTS) system
VV208B2_20660	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
VV208B2_20670	COG1846	Transcriptional regulator
VV208B2_20670	COG1940	carbohydrate kinase activity
VV208B2_20680	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
VV208B2_20680	COG4651	solute:proton antiporter activity
VV208B2_20690	COG0367	asparagine synthase
VV208B2_20710	COG3104	oligopeptide transport
VV208B2_20720	COG0840	transmembrane signaling receptor activity
VV208B2_20730	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
VV208B2_20750	COG0326	Molecular chaperone. Has ATPase activity
VV208B2_20760	COG3710	Transcriptional regulator
VV208B2_20800	COG0622	Phosphoesterase
VV208B2_20850	COG1090	epimerase
VV208B2_20860	COG0300	oxidoreductase activity
VV208B2_20870	COG3118	belongs to the thioredoxin family
VV208B2_20880	COG0330	HflC and HflK could
VV208B2_20940	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
VV208B2_20950	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
VV208B2_20960	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
VV208B2_20970	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
VV208B2_20980	COG2190	(PTS) system
VV208B2_20990	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VV208B2_21000	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VV208B2_21020	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VV208B2_21040	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VV208B2_21060	COG1705	Flagellar rod assembly protein muramidase FlgJ
VV208B2_21060	COG3951	Flagellar rod assembly protein muramidase FlgJ
VV208B2_21070	COG1706	bacterial-type flagellum-dependent cell motility
VV208B2_21100	COG4787	bacterial-type flagellum-dependent cell motility
VV208B2_21110	COG1749	Flagellar hook protein flgE
VV208B2_21140	COG1815	bacterial-type flagellum-dependent cell motility
VV208B2_21150	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
VV208B2_21160	COG0784	Response regulator, receiver
VV208B2_21160	COG0835	chemotaxis
VV208B2_21270	COG2217	Heavy metal translocating P-type atpase
VV208B2_21270	COG2608	mercury ion transmembrane transporter activity
VV208B2_21300	COG3735	TraB family
VV208B2_21320	COG2840	Smr protein MutS2
VV208B2_21330	COG1187	pseudouridine synthase activity
VV208B2_21360	COG2877	3-deoxy-8-phosphooctulonate synthase activity
VV208B2_21370	COG2912	Transglutaminase-like superfamily
VV208B2_21390	COG2890	protein-(glutamine-N5) methyltransferase activity
VV208B2_21400	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
VV208B2_21410	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
VV208B2_21430	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
VV208B2_21440	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
VV208B2_21450	COG0193	aminoacyl-tRNA hydrolase activity
VV208B2_21470	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VV208B2_21490	COG1702	phosphate starvation-inducible protein PhoH
VV208B2_21500	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
VV208B2_21510	COG4535	Mg2 and Co2 transporter CorC
VV208B2_21530	COG2888	peptidyl-tyrosine sulfation
VV208B2_21550	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
VV208B2_21560	COG1466	dna polymerase III delta subunit
VV208B2_21570	COG0799	negative regulation of ribosome biogenesis
VV208B2_21580	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
VV208B2_21590	COG0768	penicillin binding
VV208B2_21600	COG0772	Belongs to the SEDS family
VV208B2_21610	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
VV208B2_21620	COG1686	Belongs to the peptidase S11 family
VV208B2_21630	COG2921	Belongs to the UPF0250 family
VV208B2_21650	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
VV208B2_21670	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
VV208B2_21690	COG0366	Alpha amylase catalytic
VV208B2_21700	COG1263	PTS System
VV208B2_21700	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VV208B2_21720	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
VV208B2_21740	COG2011	ABC-type metal ion transport system permease component
VV208B2_21750	COG1464	Belongs to the NlpA lipoprotein family
VV208B2_21760	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
VV208B2_21810	COG1611	Belongs to the LOG family
VV208B2_21850	COG2363	Small membrane protein
VV208B2_21870	COG0583	DNA-binding transcription factor activity
VV208B2_21910	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
VV208B2_21920	COG1722	exodeoxyribonuclease VII activity
VV208B2_21930	COG0142	geranyltranstransferase activity
VV208B2_21940	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
VV208B2_21950	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
VV208B2_21960	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
VV208B2_21970	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
VV208B2_21980	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
VV208B2_22010	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
VV208B2_22010	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
VV208B2_22040	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
VV208B2_22060	COG1073	alpha beta
VV208B2_22070	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
VV208B2_22080	COG2252	PERMEase
VV208B2_22090	COG2195	Cleaves the N-terminal amino acid of tripeptides
VV208B2_22150	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
VV208B2_22170	COG0583	DNA-binding transcription factor activity
VV208B2_22180	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
VV208B2_22190	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
VV208B2_22200	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
VV208B2_22240	COG4969	Belongs to the N-Me-Phe pilin family
VV208B2_22260	COG0484	heat shock protein binding
VV208B2_22270	COG0443	Heat shock 70 kDa protein
VV208B2_22330	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
VV208B2_22340	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
VV208B2_22350	COG0497	DNA recombination
VV208B2_22360	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VV208B2_22370	COG2914	Belongs to the UPF0125 (RnfH) family
VV208B2_22380	COG2867	negative regulation of translational initiation
VV208B2_22390	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
VV208B2_22480	COG0009	L-threonylcarbamoyladenylate synthase
VV208B2_22520	COG0583	DNA-binding transcription factor activity
VV208B2_22540	COG1115	amino acid carrier protein
VV208B2_22550	COG1584	GPR1 FUN34 yaaH family protein
VV208B2_22580	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
VV208B2_22810	COG0582	viral genome integration into host DNA
VV208B2_22820	COG0518	GMP synthase (glutamine-hydrolyzing) activity
VV208B2_22820	COG0519	Catalyzes the synthesis of GMP from XMP
VV208B2_22830	COG0516	GMP reductase activity
VV208B2_22830	COG0517	IMP dehydrogenase activity
VV208B2_22860	COG2199	diguanylate cyclase activity
VV208B2_22860	COG2203	Gaf domain
VV208B2_22880	COG1160	GTP binding
VV208B2_22890	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VV208B2_22900	COG2976	Protein conserved in bacteria
VV208B2_22910	COG0124	histidyl-tRNA synthetase
VV208B2_22920	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
VV208B2_22950	COG0105	UTP biosynthetic process
VV208B2_22960	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
VV208B2_22970	COG2975	iron-sulfur cluster assembly
VV208B2_22980	COG0633	Ferredoxin
VV208B2_23010	COG0316	Belongs to the HesB IscA family
VV208B2_23020	COG0822	iron-sulfur transferase activity
VV208B2_23040	COG1959	2 iron, 2 sulfur cluster binding
VV208B2_23050	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
VV208B2_23060	COG0483	inositol monophosphate 1-phosphatase activity
VV208B2_23090	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VV208B2_23100	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VV208B2_23110	COG1862	Preprotein translocase
VV208B2_23120	COG0343	queuine tRNA-ribosyltransferase activity
VV208B2_23130	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
VV208B2_23160	COG0517	IMP dehydrogenase activity
VV208B2_23170	COG1609	Transcriptional regulator
VV208B2_23180	COG1621	beta-fructofuranosidase activity
VV208B2_23190	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VV208B2_23190	COG1263	PTS System
VV208B2_23200	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VV208B2_23220	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
VV208B2_23230	COG0583	DNA-binding transcription factor activity
VV208B2_23240	COG0450	alkyl hydroperoxide reductase
VV208B2_23310	COG0704	Plays a role in the regulation of phosphate uptake
VV208B2_23320	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
VV208B2_23330	COG0581	inorganic phosphate transmembrane transporter activity
VV208B2_23340	COG0573	inorganic phosphate transmembrane transporter activity
VV208B2_23360	COG0248	Ppx GppA phosphatase
VV208B2_23380	COG5002	protein histidine kinase activity
VV208B2_23390	COG0745	RESPONSE REGULATOR receiver
VV208B2_23410	COG0826	peptidase U32
VV208B2_23420	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
VV208B2_23440	COG0542	response to heat
VV208B2_23470	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VV208B2_23480	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
VV208B2_23490	COG0077	Prephenate dehydratase
VV208B2_23490	COG1605	Chorismate mutase
VV208B2_23510	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
VV208B2_23530	COG0488	(ABC) transporter
VV208B2_23550	COG0739	heme binding
VV208B2_23560	COG0287	Prephenate dehydrogenase
VV208B2_23560	COG1605	Chorismate mutase
VV208B2_23590	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
VV208B2_23620	COG1966	Carbon starvation protein
VV208B2_23630	COG3275	phosphorelay sensor kinase activity
VV208B2_23650	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
VV208B2_23660	COG1047	Peptidyl-prolyl cis-trans
VV208B2_23670	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
VV208B2_23680	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
VV208B2_23690	COG0196	riboflavin kinase activity
VV208B2_23700	COG0728	peptidoglycan biosynthetic process
VV208B2_23710	COG0268	Binds directly to 16S ribosomal RNA
VV208B2_23720	COG0640	Transcriptional regulator
VV208B2_23730	COG0583	DNA-binding transcription factor activity
VV208B2_23740	COG1283	sodium-dependent phosphate transmembrane transporter activity
VV208B2_23780	COG0730	response to heat
VV208B2_23800	COG0494	nUDIX hydrolase
VV208B2_23810	COG3066	DNA modification
VV208B2_23830	COG0667	Aldo Keto reductase
VV208B2_23870	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
VV208B2_23880	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
VV208B2_23890	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
VV208B2_23900	COG4974	Belongs to the 'phage' integrase family
VV208B2_23930	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
VV208B2_23940	COG0513	Belongs to the DEAD box helicase family
VV208B2_23950	COG3022	response to hydroperoxide
VV208B2_23960	COG1115	amino acid carrier protein
VV208B2_23990	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
VV208B2_24010	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
VV208B2_24020	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
VV208B2_24030	COG0083	homoserine kinase activity
VV208B2_24060	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
VV208B2_24080	COG0745	RESPONSE REGULATOR receiver
VV208B2_24100	COG2198	Histidine kinase
VV208B2_24100	COG0784	Response regulator, receiver
VV208B2_24100	COG5002	protein histidine kinase activity
VV208B2_24110	COG5001	Diguanylate cyclase
VV208B2_24110	COG2203	Gaf domain
VV208B2_24110	COG4251	negative regulation of phosphorylation
VV208B2_24110	COG3706	GGDEF domain
VV208B2_24120	COG1242	4 iron, 4 sulfur cluster binding
VV208B2_24130	COG0067	glutamate synthase
VV208B2_24130	COG0069	glutamate synthase activity
VV208B2_24130	COG0070	glutamate synthase
VV208B2_24150	COG0070	glutamate synthase
VV208B2_24150	COG0069	glutamate synthase activity
VV208B2_24150	COG0067	glutamate synthase
VV208B2_24160	COG0493	'glutamate synthase
VV208B2_24180	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
VV208B2_24200	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
VV208B2_24210	COG2860	membrane
VV208B2_24220	COG0583	DNA-binding transcription factor activity
VV208B2_24230	COG0730	response to heat
VV208B2_24250	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
VV208B2_24260	COG0505	Belongs to the CarA family
VV208B2_24280	COG0494	nUDIX hydrolase
VV208B2_24290	COG0653	protein targeting
VV208B2_24310	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
VV208B2_24320	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
VV208B2_24330	COG0849	cell division
VV208B2_24340	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
VV208B2_24350	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
VV208B2_24370	COG0772	Belongs to the SEDS family
VV208B2_24380	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
VV208B2_24390	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
VV208B2_24400	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
VV208B2_24420	COG0768	penicillin binding
VV208B2_24430	COG3116	cell division
VV208B2_24440	COG0275	rRNA processing
VV208B2_24450	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
VV208B2_24460	COG3107	peptidoglycan biosynthetic process
VV208B2_24470	COG0792	nuclease activity
VV208B2_24480	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
VV208B2_24490	COG2823	Periplasmic or secreted lipoprotein
VV208B2_24500	COG2969	positive regulation of protein catabolic process
VV208B2_24510	COG0625	glutathione transferase activity
VV208B2_24520	COG2857	Cytochrome c1
VV208B2_24530	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
VV208B2_24540	COG0723	plastoquinol--plastocyanin reductase activity
VV208B2_24550	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
VV208B2_24560	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
VV208B2_24570	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
VV208B2_24580	COG3105	Protein conserved in bacteria
VV208B2_24590	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
VV208B2_24600	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
VV208B2_24630	COG3150	esterase
VV208B2_24650	COG3151	Protein conserved in bacteria
VV208B2_24660	COG0494	nUDIX hydrolase
VV208B2_24670	COG1538	Outer membrane efflux protein
VV208B2_24690	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
VV208B2_24710	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
VV208B2_24720	COG3025	triphosphatase activity
VV208B2_24730	COG1392	Phosphate transport regulator
VV208B2_24740	COG0306	phosphate transporter
VV208B2_24750	COG4991	sh3 domain protein
VV208B2_24760	COG3267	Type II secretory pathway component ExeA
VV208B2_24760	COG3409	Peptidoglycan-binding domain 1 protein
VV208B2_24770	COG0617	tRNA 3'-terminal CCA addition
VV208B2_24780	COG1968	undecaprenyl-diphosphatase activity
VV208B2_24790	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
VV208B2_24800	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
VV208B2_24820	COG0596	Alpha beta hydrolase
VV208B2_24830	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
VV208B2_24840	COG0828	Belongs to the bacterial ribosomal protein bS21 family
VV208B2_24850	COG1610	YqeY-like protein
VV208B2_24930	COG0582	viral genome integration into host DNA
VV208B2_24940	COG0582	viral genome integration into host DNA
VV208B2_24950	COG2801	Transposase and inactivated derivatives
VV208B2_24980	COG2172	sigma factor antagonist activity
VV208B2_25020	COG2003	Belongs to the UPF0758 family
VV208B2_25090	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VV208B2_25110	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
VV208B2_25110	COG3008	intermembrane lipid transfer
VV208B2_25120	COG2995	paraquat-inducible protein a
VV208B2_25130	COG0668	transmembrane transport
VV208B2_25140	COG0328	RNA-DNA hybrid ribonuclease activity
VV208B2_25220	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
VV208B2_25230	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
VV208B2_25230	COG2213	PTS system mannitol-specific
VV208B2_25250	COG3722	fumarate hydratase activity
VV208B2_25280	COG2963	transposase activity
VV208B2_25340	COG2963	transposase activity
VV208B2_25400	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
VV208B2_25410	COG1349	DNA-binding transcription factor activity
VV208B2_25440	COG3706	GGDEF domain
VV208B2_25450	COG0440	acetolactate synthase activity
VV208B2_25460	COG0028	Belongs to the TPP enzyme family
VV208B2_25470	COG1022	Amp-dependent synthetase and ligase
VV208B2_25520	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
VV208B2_25530	COG0473	3-isopropylmalate dehydrogenase activity
VV208B2_25600	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
VV208B2_25610	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
VV208B2_25620	COG2967	ApaG domain
VV208B2_25650	COG3610	response to peptide
VV208B2_25660	COG2966	Psort location CytoplasmicMembrane, score
VV208B2_25680	COG0211	Belongs to the bacterial ribosomal protein bL27 family
VV208B2_25690	COG0261	This protein binds to 23S rRNA in the presence of protein L20
VV208B2_25700	COG0142	geranyltranstransferase activity
VV208B2_25710	COG0039	L-malate dehydrogenase activity
VV208B2_25720	COG1438	arginine binding
VV208B2_25730	COG2358	TRAP transporter, solute receptor (TAXI family
VV208B2_25750	COG0589	response to stress
VV208B2_25760	COG0204	Acyl-transferase
VV208B2_25770	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
VV208B2_25780	COG5007	Belongs to the BolA IbaG family
VV208B2_25800	COG2854	intermembrane phospholipid transfer
VV208B2_25810	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
VV208B2_25820	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
VV208B2_25830	COG1127	ABC transporter
VV208B2_25850	COG0517	IMP dehydrogenase activity
VV208B2_25850	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
VV208B2_25860	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
VV208B2_25880	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
VV208B2_25890	COG1137	ATPase activity
VV208B2_25910	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
VV208B2_25920	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
VV208B2_25930	COG1660	Displays ATPase and GTPase activities
VV208B2_25940	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
VV208B2_25950	COG2239	Acts as a magnesium transporter
VV208B2_25960	COG0312	modulator of DNA gyrase
VV208B2_25970	COG3028	Belongs to the UPF0307 family
VV208B2_25980	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
VV208B2_25990	COG1178	ABC-type Fe3 transport system permease component
VV208B2_26000	COG4143	(ABC) transporter
VV208B2_26010	COG0163	prenyltransferase activity
VV208B2_26020	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
VV208B2_26030	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
VV208B2_26040	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
VV208B2_26060	COG2105	PFAM AIG2 family protein
VV208B2_26070	COG2911	Protein conserved in bacteria
VV208B2_26080	COG0729	surface antigen
VV208B2_26110	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
VV208B2_26140	COG1136	(ABC) transporter
VV208B2_26140	COG0577	efflux transmembrane transporter activity
VV208B2_26180	COG0529	Catalyzes the synthesis of activated sulfate
VV208B2_26190	COG0471	metal ion transport
VV208B2_26190	COG3273	potassium ion transport
VV208B2_26200	COG2895	sulfate adenylyltransferase (ATP) activity
VV208B2_26210	COG0175	sulfate reduction
VV208B2_26220	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
VV208B2_26220	COG1648	precorrin-2 dehydrogenase activity
VV208B2_26230	COG0737	Belongs to the 5'-nucleotidase family
VV208B2_26250	COG2153	protein acetylation
VV208B2_26270	COG3061	Opacity-associated protein A
VV208B2_26270	COG3266	domain, Protein
VV208B2_26280	COG0545	Peptidyl-prolyl cis-trans isomerase
VV208B2_26300	COG0203	ribosomal protein L17
VV208B2_26310	COG0202	RNA polymerase activity
VV208B2_26320	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
VV208B2_26330	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
VV208B2_26340	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
VV208B2_26350	COG0201	protein transport
VV208B2_26360	COG0200	Binds to the 23S rRNA
VV208B2_26370	COG1841	ribosomal large subunit assembly
VV208B2_26380	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
VV208B2_26390	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
VV208B2_26400	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
VV208B2_26410	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
VV208B2_26420	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
VV208B2_26430	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
VV208B2_26440	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
VV208B2_26450	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
VV208B2_26460	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
VV208B2_26470	COG0255	Belongs to the universal ribosomal protein uL29 family
VV208B2_26480	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
VV208B2_26490	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
VV208B2_26510	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
VV208B2_26520	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
VV208B2_26530	COG0089	rRNA binding
VV208B2_26540	COG0088	Forms part of the polypeptide exit tunnel
VV208B2_26570	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
VV208B2_26620	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
VV208B2_26630	COG2030	dehydratase
VV208B2_26650	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
VV208B2_26700	COG5433	transposase activity
VV208B2_26720	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
VV208B2_26730	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
VV208B2_26740	COG0489	protein tyrosine kinase activity
VV208B2_26740	COG3206	protein involved in exopolysaccharide biosynthesis
VV208B2_26780	COG1596	polysaccharide export
VV208B2_26840	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VV208B2_26870	COG0859	PFAM glycosyl transferase family 9
VV208B2_26880	COG1519	Transferase
VV208B2_26920	COG1083	cytidylyl-transferase
VV208B2_26960	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
VV208B2_26970	COG2089	acid synthase
VV208B2_26990	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
VV208B2_27020	COG3083	sulfuric ester hydrolase activity
VV208B2_27040	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
VV208B2_27050	COG0859	PFAM glycosyl transferase family 9
VV208B2_27060	COG0463	Glycosyl transferase, family 2
VV208B2_27070	COG0859	PFAM glycosyl transferase family 9
VV208B2_27080	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
VV208B2_27120	COG0267	Belongs to the bacterial ribosomal protein bL33 family
VV208B2_27130	COG0227	Belongs to the bacterial ribosomal protein bL28 family
VV208B2_27140	COG2003	Belongs to the UPF0758 family
VV208B2_27160	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
VV208B2_27170	COG1309	transcriptional regulator
VV208B2_27180	COG1560	Kdo2-lipid A biosynthetic process
VV208B2_27200	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
VV208B2_27210	COG1561	YicC-like family, N-terminal region
VV208B2_27250	COG4608	Belongs to the ABC transporter superfamily
VV208B2_27260	COG0444	Belongs to the ABC transporter superfamily
VV208B2_27270	COG0747	negative chemotaxis
VV208B2_27280	COG4239	(ABC) transporter, permease
VV208B2_27290	COG4174	ABC transporter (Permease)
VV208B2_27300	COG4206	TonB-dependent receptor
VV208B2_27320	COG0811	peptide transport
VV208B2_27330	COG0811	peptide transport
VV208B2_27340	COG0848	biopolymer transport protein
VV208B2_27370	COG0194	GDP metabolic process
VV208B2_27380	COG1758	RNA polymerase activity
VV208B2_27390	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
VV208B2_27400	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
VV208B2_27410	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
VV208B2_27420	COG2233	PERMEase
VV208B2_27450	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
VV208B2_27460	COG2183	response to ionizing radiation
VV208B2_27480	COG0596	Alpha beta hydrolase
VV208B2_27490	COG1040	competence protein
VV208B2_27500	COG0316	Belongs to the HesB IscA family
VV208B2_27500	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
VV208B2_27510	COG0494	nUDIX hydrolase
VV208B2_27520	COG1218	3'(2'),5'-bisphosphate nucleotidase
VV208B2_27540	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
VV208B2_27550	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
VV208B2_27560	COG3156	type II secretion system protein K
VV208B2_27570	COG4795	General secretion pathway protein
VV208B2_27580	COG2165	general secretion pathway protein
VV208B2_27590	COG2165	general secretion pathway protein
VV208B2_27600	COG2165	general secretion pathway protein
VV208B2_27610	COG1459	type II secretion system
VV208B2_27620	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
VV208B2_27640	COG3031	protein transport across the cell outer membrane
VV208B2_27650	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
VV208B2_27660	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
VV208B2_27690	COG0456	acetyltransferase
VV208B2_27700	COG1490	D-aminoacyl-tRNA deacylase activity
VV208B2_27710	COG1295	ribonuclease BN
VV208B2_27740	COG1217	gtp-binding protein TYPA
VV208B2_27750	COG0174	glutamine synthetase
VV208B2_27770	COG3852	Histidine kinase
VV208B2_27780	COG2204	response regulator
VV208B2_27790	COG3300	MHYT domain
VV208B2_27790	COG5001	Diguanylate cyclase
VV208B2_27860	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
VV208B2_27860	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
VV208B2_27880	COG0084	hydrolase, TatD family'
VV208B2_27890	COG0805	protein transport
VV208B2_27900	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
VV208B2_27910	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
VV208B2_27930	COG3165	ubiquinone biosynthetic process from chorismate
VV208B2_27940	COG2226	methyltransferase
VV208B2_27950	COG1322	Protein conserved in bacteria
VV208B2_27980	COG3335	DDE superfamily endonuclease
VV208B2_28060	COG3118	belongs to the thioredoxin family
VV208B2_28080	COG0248	Ppx GppA phosphatase
VV208B2_28090	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
VV208B2_28110	COG0514	ATP-dependent DNA helicase (RecQ)
VV208B2_28120	COG2962	Rard protein
VV208B2_28140	COG1280	lysine exporter protein (LysE YggA)
VV208B2_28150	COG0210	DNA helicase
VV208B2_28230	COG0006	proline dipeptidase activity
VV208B2_28230	COG0006	proline dipeptidase activity
VV208B2_28250	COG2022	thiamine diphosphate biosynthetic process
VV208B2_28260	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
VV208B2_28280	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
VV208B2_28290	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
VV208B2_28300	COG2132	Multicopper oxidase
VV208B2_28330	COG3335	DDE superfamily endonuclease
VV208B2_28340	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
VV208B2_28380	COG0009	L-threonylcarbamoyladenylate synthase
VV208B2_28390	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
VV208B2_28420	COG0551	DNA topoisomerase type I activity
VV208B2_28430	COG2922	Belongs to the Smg family
VV208B2_28440	COG0758	DNA mediated transformation
VV208B2_28460	COG0242	peptide deformylase activity
VV208B2_28470	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
VV208B2_28480	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
VV208B2_28480	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
VV208B2_28490	COG0569	domain protein
VV208B2_28500	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
VV208B2_28510	COG1272	protein, Hemolysin III
VV208B2_28520	COG4326	sporulation control protein
VV208B2_28530	COG3084	Protein conserved in bacteria
VV208B2_28550	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
VV208B2_28560	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
VV208B2_28570	COG0204	Acyl-transferase
VV208B2_28590	COG0606	chelatase, subunit chli
VV208B2_28610	COG3978	acetolactate synthase activity
VV208B2_28620	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
VV208B2_28650	COG0583	DNA-binding transcription factor activity
VV208B2_28660	COG2814	Major facilitator Superfamily
VV208B2_28680	COG0765	amino acid transport
VV208B2_28690	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
VV208B2_28700	COG0355	proton-transporting ATP synthase activity, rotational mechanism
VV208B2_28710	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
VV208B2_28720	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
VV208B2_28730	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
VV208B2_28740	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
VV208B2_28750	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
VV208B2_28770	COG0356	it plays a direct role in the translocation of protons across the membrane
VV208B2_28780	COG3312	ion transport
VV208B2_28790	COG1475	DNA binding
VV208B2_28800	COG1192	Involved in chromosome partitioning
VV208B2_28810	COG0357	Ribosomal RNA small subunit methyltransferase G
VV208B2_28820	COG0445	tRNA wobble uridine modification
VV208B2_28830	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
VV208B2_28860	COG0594	ribonuclease P activity
VV208B2_28870	COG1126	abc transporter atp-binding protein
VV208B2_28900	COG5444	nuclease activity
VV208B2_28940	COG0501	Belongs to the peptidase M48B family
VV208B2_28950	COG1704	LemA family
VV208B2_28960	COG3069	C4-dicarboxylate transmembrane transporter activity
VV208B2_28980	COG0312	modulator of DNA gyrase
VV208B2_28990	COG0312	modulator of DNA gyrase
VV208B2_29000	COG0584	glycerophosphoryl diester phosphodiesterase
VV208B2_29010	COG2271	Major facilitator Superfamily
VV208B2_29050	COG0840	transmembrane signaling receptor activity
VV208B2_29060	COG0840	transmembrane signaling receptor activity
VV208B2_29070	COG0366	Alpha amylase catalytic
VV208B2_29090	COG0243	molybdopterin cofactor binding
VV208B2_29100	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
VV208B2_29100	COG1648	precorrin-2 dehydrogenase activity
VV208B2_29130	COG3707	response regulator
VV208B2_29140	COG1116	anion transmembrane transporter activity
VV208B2_29140	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
VV208B2_29150	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
VV208B2_29160	COG1116	anion transmembrane transporter activity
VV208B2_29170	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
VV208B2_29170	COG2146	nitrite reductase [NAD(P)H] activity
VV208B2_29200	COG2199	diguanylate cyclase activity
VV208B2_29220	COG0523	cobalamin synthesis protein
VV208B2_29240	COG0513	Belongs to the DEAD box helicase family
VV208B2_29250	COG0010	Belongs to the arginase family
VV208B2_29270	COG4251	negative regulation of phosphorylation
VV208B2_29270	COG3706	GGDEF domain
VV208B2_29270	COG2203	Gaf domain
VV208B2_29270	COG5001	Diguanylate cyclase
VV208B2_29290	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
VV208B2_29350	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
VV208B2_29420	COG0811	peptide transport
VV208B2_29430	COG0811	peptide transport
VV208B2_29440	COG0848	biopolymer transport protein
VV208B2_29470	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
VV208B2_29510	COG0534	Mate efflux family protein
VV208B2_29530	COG0477	Major facilitator Superfamily
VV208B2_29540	COG3118	belongs to the thioredoxin family
VV208B2_29550	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
VV208B2_29660	COG1328	CTP reductase activity
VV208B2_29670	COG0602	queuosine metabolic process
VV208B2_29690	COG0840	transmembrane signaling receptor activity
VV208B2_29710	COG4067	protein conserved in archaea
VV208B2_29710	COG0189	ligase activity
VV208B2_29750	COG0725	ABC transporter, periplasmic molybdate-binding protein
VV208B2_29760	COG4149	molybdate abc transporter
VV208B2_29770	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
VV208B2_29780	COG0697	spore germination
VV208B2_29790	COG1846	Transcriptional regulator
VV208B2_29810	COG2199	diguanylate cyclase activity
VV208B2_29830	COG3706	GGDEF domain
VV208B2_29860	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
VV208B2_29870	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
VV208B2_29890	COG0745	RESPONSE REGULATOR receiver
VV208B2_29920	COG3140	Belongs to the UPF0181 family
VV208B2_29940	COG0023	Translation Initiation Factor
VV208B2_29980	COG1042	CoA-binding domain protein
VV208B2_29980	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VV208B2_29980	COG0045	succinate-CoA ligase (ADP-forming) activity
VV208B2_29990	COG0583	DNA-binding transcription factor activity
VV208B2_30010	COG3447	MASE1 domain protein
VV208B2_30010	COG5001	Diguanylate cyclase
VV208B2_30010	COG5002	protein histidine kinase activity
VV208B2_30030	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
VV208B2_30040	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
VV208B2_30050	COG1984	allophanate hydrolase subunit 2
VV208B2_30060	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
VV208B2_30060	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
VV208B2_30070	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
VV208B2_30080	COG4181	ATPase activity
VV208B2_30100	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
VV208B2_30110	COG1716	ATPase activity
VV208B2_30110	COG5001	Diguanylate cyclase
VV208B2_30140	COG0484	heat shock protein binding
VV208B2_30180	COG0583	DNA-binding transcription factor activity
VV208B2_30190	COG0366	Alpha amylase catalytic
VV208B2_30210	COG4533	DNA binding
VV208B2_30230	COG2050	protein possibly involved in aromatic compounds catabolism
VV208B2_30260	COG2067	long-chain fatty acid transport protein
VV208B2_30270	COG2267	carboxylic ester hydrolase activity
VV208B2_30330	COG0861	Integral membrane protein TerC family
VV208B2_30340	COG0737	Belongs to the 5'-nucleotidase family
VV208B2_30350	COG3593	DNA synthesis involved in DNA repair
VV208B2_30370	COG0583	DNA-binding transcription factor activity
VV208B2_30380	COG2116	formate transmembrane transporter activity
VV208B2_30390	COG2353	YceI-like domain
VV208B2_30400	COG3038	cytochrome b561
VV208B2_30430	COG0513	Belongs to the DEAD box helicase family
VV208B2_30470	COG0546	phosphoglycolate phosphatase activity
VV208B2_30480	COG0784	Response regulator, receiver
VV208B2_30480	COG3437	response regulator, receiver
VV208B2_30510	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VV208B2_30520	COG2759	Belongs to the formate--tetrahydrofolate ligase family
VV208B2_30530	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
VV208B2_30550	COG2207	Transcriptional regulator
VV208B2_30560	COG1979	alcohol dehydrogenase
VV208B2_30580	COG4191	Histidine kinase
VV208B2_30600	COG2271	Major facilitator Superfamily
VV208B2_30610	COG0469	pyruvate kinase activity
VV208B2_30660	COG1609	Transcriptional regulator
VV208B2_30670	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
VV208B2_30670	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
VV208B2_30680	COG1105	Belongs to the carbohydrate kinase PfkB family
VV208B2_30690	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
VV208B2_30690	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VV208B2_30690	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VV208B2_30780	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
VV208B2_30790	COG0509	glycine decarboxylation via glycine cleavage system
VV208B2_30800	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
VV208B2_30800	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
VV208B2_30820	COG1132	(ABC) transporter
VV208B2_30930	COG2814	Major facilitator Superfamily
VV208B2_30990	COG0641	radical SAM
VV208B2_31010	COG1524	type I phosphodiesterase nucleotide pyrophosphatase
VV208B2_31080	COG0714	Associated with various cellular activities
VV208B2_31090	COG0641	radical SAM
VV208B2_31100	COG3119	arylsulfatase activity
VV208B2_31120	COG3119	arylsulfatase activity
VV208B2_31130	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
VV208B2_31140	COG0513	Belongs to the DEAD box helicase family
VV208B2_31150	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
VV208B2_31180	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
VV208B2_31230	COG1716	ATPase activity
VV208B2_31230	COG5001	Diguanylate cyclase
VV208B2_31250	COG0513	Belongs to the DEAD box helicase family
VV208B2_31300	COG3005	denitrification pathway
VV208B2_31310	COG1262	PFAM Formylglycine-generating sulfatase enzyme
VV208B2_31350	COG2205	protein histidine kinase activity
VV208B2_31350	COG0784	Response regulator, receiver
VV208B2_31350	COG2198	Histidine kinase
VV208B2_31360	COG1879	ABC-type sugar transport system periplasmic component
VV208B2_31370	COG1803	Methylglyoxal synthase
VV208B2_31380	COG0210	DNA helicase
VV208B2_31390	COG1289	transmembrane transporter activity
VV208B2_31460	COG0789	Transcriptional regulator
VV208B2_31470	COG4604	ABC transporter, ATP-binding protein
VV208B2_31480	COG4605	iron ion homeostasis
VV208B2_31490	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VV208B2_31540	COG0110	maltose O-acetyltransferase activity
VV208B2_31560	COG3290	protein histidine kinase activity
VV208B2_31570	COG0471	metal ion transport
VV208B2_31730	COG4964	Belongs to the GSP D family
VV208B2_31760	COG0583	DNA-binding transcription factor activity
VV208B2_31780	COG0419	ATPase involved in DNA repair
VV208B2_31790	COG0420	3'-5' exonuclease activity
VV208B2_31800	COG3437	response regulator, receiver
VV208B2_31820	COG2801	Transposase and inactivated derivatives
VV208B2_31840	COG2172	sigma factor antagonist activity
VV208B2_31860	COG1366	Belongs to the anti-sigma-factor antagonist family
VV208B2_31890	COG0456	acetyltransferase
VV208B2_31910	COG0835	chemotaxis
VV208B2_31910	COG0784	Response regulator, receiver
VV208B2_31930	COG1609	Transcriptional regulator
VV208B2_31940	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VV208B2_31950	COG1879	ABC-type sugar transport system periplasmic component
VV208B2_31960	COG1172	Belongs to the binding-protein-dependent transport system permease family
VV208B2_31980	COG1869	D-ribose catabolic process
VV208B2_32010	COG2315	Protein conserved in bacteria
VV208B2_32020	COG2425	protein containing a von Willebrand factor type A (vWA) domain
VV208B2_32050	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
VV208B2_32080	COG1288	antiporter activity
VV208B2_32100	COG0671	phosphoesterase, PA-phosphatase related
VV208B2_32110	COG3097	Belongs to the UPF0267 family
VV208B2_32130	COG2962	Rard protein
VV208B2_32190	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
VV208B2_32200	COG0814	amino acid
VV208B2_32250	COG3174	membrane
VV208B2_32260	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VV208B2_32320	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VV208B2_32330	COG0443	Heat shock 70 kDa protein
VV208B2_32340	COG1454	alcohol dehydrogenase
VV208B2_32360	COG2133	pyrroloquinoline quinone binding
VV208B2_32370	COG1619	proteins homologs of microcin C7 resistance protein MccF
VV208B2_32400	COG0247	lactate metabolic process
VV208B2_32420	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
VV208B2_32460	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
VV208B2_32490	COG3059	membrane
VV208B2_32500	COG4175	Glycine betaine
VV208B2_32540	COG1012	belongs to the aldehyde dehydrogenase family
VV208B2_32550	COG1309	transcriptional regulator
VV208B2_32590	COG1686	Belongs to the peptidase S11 family
VV208B2_32630	COG1760	l-serine dehydratase
VV208B2_32640	COG3104	oligopeptide transport
VV208B2_32660	COG0583	DNA-binding transcription factor activity
VV208B2_32670	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
VV208B2_32710	COG3842	ATPase activity
VV208B2_32720	COG1840	ABC-type Fe3 transport system, periplasmic component
VV208B2_32730	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
VV208B2_32740	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
VV208B2_32760	COG2207	Transcriptional regulator
VV208B2_32760	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
VV208B2_32770	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
VV208B2_32820	COG1011	Hydrolase
VV208B2_32870	COG1765	OsmC-like protein
VV208B2_32880	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VV208B2_32880	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VV208B2_32890	COG3706	GGDEF domain
VV208B2_32920	COG0840	transmembrane signaling receptor activity
VV208B2_32960	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
VV208B2_33000	COG2084	Dehydrogenase
VV208B2_33040	COG0739	heme binding
VV208B2_33080	COG3314	Sporulation integral membrane protein YlbJ
VV208B2_33110	COG0840	transmembrane signaling receptor activity
VV208B2_33130	COG0366	Alpha amylase catalytic
VV208B2_33140	COG0589	response to stress
VV208B2_33150	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
VV208B2_33160	COG0784	Response regulator, receiver
VV208B2_33160	COG0835	chemotaxis
VV208B2_33180	COG0748	coenzyme F420 binding
VV208B2_33190	COG3721	Heme iron utilization protein
VV208B2_33210	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
VV208B2_33220	COG0811	peptide transport
VV208B2_33230	COG0848	biopolymer transport protein
VV208B2_33250	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VV208B2_33260	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
VV208B2_33360	COG3217	Mosc domain protein beta barrel domain protein
VV208B2_33360	COG0633	Ferredoxin
VV208B2_33360	COG3217	Mosc domain protein beta barrel domain protein
VV208B2_33360	COG0633	Ferredoxin
VV208B2_33370	COG0418	dihydroorotase activity
VV208B2_33390	COG2354	Protein conserved in bacteria
VV208B2_33450	COG3833	ABC-type maltose transport systems, permease component
VV208B2_33460	COG1175	transmembrane transport
VV208B2_33480	COG3842	ATPase activity
VV208B2_33490	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
VV208B2_33510	COG1596	polysaccharide export
VV208B2_33650	COG0714	Associated with various cellular activities
VV208B2_33690	COG2304	oxidoreductase activity
VV208B2_33710	COG2203	Gaf domain
VV208B2_33710	COG4251	negative regulation of phosphorylation
VV208B2_33710	COG5001	Diguanylate cyclase
VV208B2_33710	COG3706	GGDEF domain
VV208B2_33730	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
VV208B2_33740	COG0581	inorganic phosphate transmembrane transporter activity
VV208B2_33750	COG0573	inorganic phosphate transmembrane transporter activity
VV208B2_33830	COG0513	Belongs to the DEAD box helicase family
VV208B2_33850	COG1388	LysM domain
VV208B2_33850	COG1376	ErfK ybiS ycfS ynhG family protein
VV208B2_33860	COG0415	Belongs to the DNA photolyase family
VV208B2_33870	COG0789	Transcriptional regulator
VV208B2_33880	COG3272	Protein of unknown function (DUF1722)
VV208B2_33890	COG0813	purine-nucleoside phosphorylase activity
VV208B2_33940	COG1566	PFAM secretion protein HlyD family protein
VV208B2_33950	COG4720	Psort location CytoplasmicMembrane, score
VV208B2_33990	COG4946	Tricorn protease homolog
VV208B2_33990	COG0793	Belongs to the peptidase S41A family
VV208B2_34000	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VV208B2_34050	COG0668	transmembrane transport
VV208B2_34090	COG1538	Outer membrane efflux protein
VV208B2_34110	COG2274	protein secretion by the type I secretion system
VV208B2_34130	COG3111	PFAM Bacterial OB fold (BOF) protein
VV208B2_34140	COG0784	Response regulator, receiver
VV208B2_34140	COG2205	protein histidine kinase activity
VV208B2_34180	COG2197	response regulator
VV208B2_34210	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
VV208B2_34280	COG3040	lipid binding
VV208B2_34360	COG1063	alcohol dehydrogenase
VV208B2_34380	COG3240	lipase activity
VV208B2_34410	COG2211	Major facilitator Superfamily
VV208B2_34430	COG0346	lactoylglutathione lyase activity
VV208B2_34450	COG0753	catalase activity
VV208B2_34490	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
VV208B2_34510	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
VV208B2_34540	COG0393	Putative heavy-metal-binding
VV208B2_34590	COG4771	TonB-dependent receptor
VV208B2_34600	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
VV208B2_34610	COG0039	L-malate dehydrogenase activity
VV208B2_34650	COG2814	Major facilitator Superfamily
VV208B2_34700	COG0351	phosphomethylpyrimidine kinase
VV208B2_34710	COG0671	phosphoesterase, PA-phosphatase related
VV208B2_34740	COG0561	phosphatase activity
VV208B2_34760	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
VV208B2_34770	COG0076	glutamate decarboxylase activity
VV208B2_34780	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
VV208B2_34830	COG4221	oxidoreductase activity
VV208B2_34860	COG0745	RESPONSE REGULATOR receiver
VV208B2_34870	COG2205	protein histidine kinase activity
VV208B2_34880	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
VV208B2_34890	COG2194	sulfuric ester hydrolase activity
VV208B2_34900	COG1368	sulfuric ester hydrolase activity
VV208B2_34930	COG2356	endonuclease I
VV208B2_34960	COG3335	DDE superfamily endonuclease
VV208B2_34970	COG3706	GGDEF domain
VV208B2_34990	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
VV208B2_35060	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
VV208B2_35160	COG1301	dicarboxylic acid transport
VV208B2_35180	COG0137	argininosuccinate synthase activity
VV208B2_35220	COG1733	regulation of RNA biosynthetic process
VV208B2_35230	COG0583	DNA-binding transcription factor activity
VV208B2_35300	COG0768	penicillin binding
VV208B2_35340	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
VV208B2_35350	COG1482	cell wall glycoprotein biosynthetic process
VV208B2_35360	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
VV208B2_35370	COG1263	PTS System
VV208B2_35370	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VV208B2_35380	COG1609	Transcriptional regulator
VV208B2_35400	COG3383	formate dehydrogenase (NAD+) activity
VV208B2_35440	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VV208B2_35460	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
VV208B2_35490	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VV208B2_35500	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VV208B2_35520	COG2207	Transcriptional regulator
VV208B2_35530	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
VV208B2_35530	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VV208B2_35530	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VV208B2_35540	COG1482	cell wall glycoprotein biosynthetic process
VV208B2_35640	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
VV208B2_35650	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
VV208B2_35660	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
VV208B2_35680	COG2211	Major facilitator Superfamily
VV208B2_35700	COG3250	beta-galactosidase activity
VV208B2_35720	COG1129	ABC transporter
VV208B2_35740	COG1609	Transcriptional regulator
VV208B2_35780	COG3706	GGDEF domain
VV208B2_35790	COG0564	pseudouridine synthase activity
VV208B2_35870	COG1566	PFAM secretion protein HlyD family protein
VV208B2_35890	COG0534	Mate efflux family protein
VV208B2_35900	COG1472	Belongs to the glycosyl hydrolase 3 family
VV208B2_35920	COG4580	involved in the transport of maltose and maltodextrins
VV208B2_35950	COG1609	Transcriptional regulator
VV208B2_35970	COG4608	Belongs to the ABC transporter superfamily
VV208B2_35980	COG0444	Belongs to the ABC transporter superfamily
VV208B2_35990	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VV208B2_36010	COG0747	negative chemotaxis
VV208B2_36030	COG1609	Transcriptional regulator
VV208B2_36040	COG3842	ATPase activity
VV208B2_36060	COG0395	ABC-type sugar transport system, permease component
VV208B2_36090	COG1609	Transcriptional regulator
VV208B2_36110	COG2199	diguanylate cyclase activity
VV208B2_36140	COG1028	Short-chain dehydrogenase reductase Sdr
VV208B2_36170	COG0642	Histidine kinase
VV208B2_36200	COG0583	DNA-binding transcription factor activity
VV208B2_36220	COG0612	Peptidase, M16
VV208B2_36230	COG1283	sodium-dependent phosphate transmembrane transporter activity
VV208B2_36240	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
VV208B2_36250	COG0625	glutathione transferase activity
VV208B2_36260	COG1012	belongs to the aldehyde dehydrogenase family
VV208B2_36370	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
VV208B2_36380	COG0840	transmembrane signaling receptor activity
VV208B2_36390	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
VV208B2_36400	COG1640	4-alpha-glucanotransferase
VV208B2_36410	COG0058	SHG alpha-glucan phosphorylase activity
VV208B2_36420	COG2909	trisaccharide binding
VV208B2_36470	COG1999	signal sequence binding
VV208B2_36480	COG2847	Copper chaperone PCu(A)C
VV208B2_36490	COG1162	GTPase activity
VV208B2_36500	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
VV208B2_36520	COG0531	amino acid
VV208B2_36530	COG1982	Orn Lys Arg decarboxylase major
VV208B2_36620	COG3706	GGDEF domain
VV208B2_36640	COG5001	Diguanylate cyclase
VV208B2_36660	COG1741	Belongs to the pirin family
VV208B2_36670	COG3123	guanosine phosphorylase activity
VV208B2_36710	COG1309	transcriptional regulator
VV208B2_36750	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
VV208B2_36760	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
VV208B2_36770	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
VV208B2_36820	COG0189	ligase activity
VV208B2_36850	COG0363	glucosamine-6-phosphate deaminase activity
VV208B2_36870	COG0786	glutamate:sodium symporter activity
VV208B2_36880	COG0786	glutamate:sodium symporter activity
VV208B2_36920	COG3275	phosphorelay sensor kinase activity
VV208B2_36950	COG4591	ABC-type transport system involved in lipoprotein release permease component
VV208B2_36960	COG1136	(ABC) transporter
VV208B2_36980	COG0583	DNA-binding transcription factor activity
VV208B2_37000	COG0217	transcriptional regulatory protein
VV208B2_37040	COG3385	transposase activity
VV208B2_37050	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
VV208B2_37050	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
VV208B2_37070	COG0444	Belongs to the ABC transporter superfamily
VV208B2_37080	COG4608	Belongs to the ABC transporter superfamily
VV208B2_37130	COG1444	tRNA N-acetyltransferase activity
VV208B2_37150	COG0745	RESPONSE REGULATOR receiver
VV208B2_37180	COG0835	chemotaxis
VV208B2_37190	COG0840	transmembrane signaling receptor activity
VV208B2_37200	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
VV208B2_37230	COG0840	transmembrane signaling receptor activity
VV208B2_37290	COG1566	PFAM secretion protein HlyD family protein
VV208B2_37310	COG0789	Transcriptional regulator
VV208B2_37380	COG0406	alpha-ribazole phosphatase activity
VV208B2_37390	COG2199	diguanylate cyclase activity
VV208B2_37390	COG2200	EAL domain
VV208B2_37390	COG2203	Gaf domain
VV208B2_37410	COG1263	PTS System
VV208B2_37410	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VV208B2_37420	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
VV208B2_37430	COG1737	Transcriptional regulator
VV208B2_37440	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
VV208B2_37440	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
VV208B2_37470	COG0110	maltose O-acetyltransferase activity
VV208B2_37480	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
VV208B2_37490	COG0459	protein refolding
VV208B2_37560	COG2204	response regulator
VV208B2_37580	COG0259	pyridoxamine-phosphate oxidase activity
VV208B2_37640	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
VV208B2_37690	COG5492	domain, Protein
VV208B2_37700	COG3119	arylsulfatase activity
VV208B2_37710	COG3119	arylsulfatase activity
VV208B2_37720	COG0641	radical SAM
VV208B2_37730	COG3119	arylsulfatase activity
VV208B2_37760	COG0601	transmembrane transport
VV208B2_37770	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VV208B2_37820	COG0659	secondary active sulfate transmembrane transporter activity
VV208B2_37830	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
VV208B2_37850	COG1028	Short-chain dehydrogenase reductase Sdr
VV208B2_37870	COG5426	von Willebrand factor, type A
VV208B2_37880	COG5492	domain, Protein
VV208B2_37890	COG1132	(ABC) transporter
VV208B2_37920	COG3623	hexulose-6-phosphate isomerase
VV208B2_37930	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
VV208B2_37940	COG0561	phosphatase activity
VV208B2_38000	COG1902	pentaerythritol trinitrate reductase activity
VV208B2_38010	COG2999	glutathione oxidoreductase activity
VV208B2_38020	COG1028	Short-chain dehydrogenase reductase Sdr
VV208B2_38050	COG0800	Aldolase
VV208B2_38060	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VV208B2_38070	COG1904	glucuronate isomerase
VV208B2_38080	COG0246	Mannitol dehydrogenase
VV208B2_38100	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
VV208B2_38120	COG2186	Transcriptional regulator
VV208B2_38140	COG0513	Belongs to the DEAD box helicase family
VV208B2_38160	COG1078	dGTPase activity
VV208B2_38190	COG1129	ABC transporter
VV208B2_38200	COG1172	Belongs to the binding-protein-dependent transport system permease family
VV208B2_38230	COG2258	MOSC domain
VV208B2_38290	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
VV208B2_38320	COG0840	transmembrane signaling receptor activity
VV208B2_38360	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VV208B2_38370	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VV208B2_38420	COG2015	COG2015, Alkyl sulfatase and related hydrolases
VV208B2_38460	COG2207	Transcriptional regulator
VV208B2_38470	COG0697	spore germination
VV208B2_38480	COG1349	DNA-binding transcription factor activity
VV208B2_38490	COG1349	DNA-binding transcription factor activity
VV208B2_38510	COG2222	sugar isomerase
VV208B2_38520	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VV208B2_38540	COG3716	PTS system mannose fructose sorbose family IID component
VV208B2_38550	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
VV208B2_38610	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
VV208B2_38620	COG1120	ATPase activity
VV208B2_38680	COG0577	efflux transmembrane transporter activity
VV208B2_38680	COG1136	(ABC) transporter
VV208B2_38690	COG0577	efflux transmembrane transporter activity
VV208B2_38690	COG1136	(ABC) transporter
VV208B2_38700	COG2176	DNA-directed DNA polymerase activity
VV208B2_38730	COG3706	GGDEF domain
VV208B2_38810	COG2205	protein histidine kinase activity
VV208B2_38850	COG2015	COG2015, Alkyl sulfatase and related hydrolases
VV208B2_38880	COG2204	response regulator
VV208B2_38910	COG0579	oxidoreductase
VV208B2_38930	COG3437	response regulator, receiver
VV208B2_38970	COG1357	PFAM Pentapeptide repeats (8 copies)
VV208B2_38990	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
VV208B2_39060	COG0513	Belongs to the DEAD box helicase family
VV208B2_39100	COG0583	DNA-binding transcription factor activity
VV208B2_39120	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
VV208B2_39180	COG2814	Major facilitator Superfamily
VV208B2_39220	COG0583	DNA-binding transcription factor activity
VV208B2_39260	COG1858	cytochrome C peroxidase
VV208B2_39310	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
VV208B2_39320	COG0454	-acetyltransferase
VV208B2_39360	COG2205	protein histidine kinase activity
VV208B2_39410	COG3046	protein related to deoxyribodipyrimidine photolyase
VV208B2_39420	COG2207	Transcriptional regulator
VV208B2_39430	COG1881	PFAM PEBP family protein
VV208B2_39440	COG0494	nUDIX hydrolase
VV208B2_39500	COG0668	transmembrane transport
VV208B2_39540	COG3153	acetyltransferase
VV208B2_39540	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
VV208B2_39600	COG1028	Short-chain dehydrogenase reductase Sdr
VV208B2_39620	COG1917	Cupin 2, conserved barrel domain protein
VV208B2_39650	COG1204	response to ionizing radiation
VV208B2_39680	COG0697	spore germination
VV208B2_39690	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VV208B2_39700	COG0800	Aldolase
VV208B2_39730	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
VV208B2_39760	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
VV208B2_39770	COG0823	Involved in the tonB-independent uptake of proteins
VV208B2_39780	COG0366	Alpha amylase catalytic
VV208B2_39800	COG3366	ferrous iron transmembrane transporter activity
VV208B2_39810	COG0700	Nucleoside recognition
VV208B2_39820	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
VV208B2_39850	COG0583	DNA-binding transcription factor activity
VV208B2_39890	COG0640	Transcriptional regulator
VV208B2_39900	COG0798	PFAM Bile acid sodium symporter
VV208B2_39940	COG2194	sulfuric ester hydrolase activity
VV208B2_39980	COG1566	PFAM secretion protein HlyD family protein
VV208B2_40000	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
VV208B2_40020	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
VV208B2_40030	COG0583	DNA-binding transcription factor activity
VV208B2_40050	COG0583	DNA-binding transcription factor activity
VV208B2_40070	COG2015	COG2015, Alkyl sulfatase and related hydrolases
VV208B2_40120	COG0673	inositol 2-dehydrogenase activity
VV208B2_40130	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
VV208B2_40140	COG2197	response regulator
VV208B2_40150	COG0384	phenazine biosynthesis protein PhzF
VV208B2_40170	COG0625	glutathione transferase activity
VV208B2_40180	COG1879	ABC-type sugar transport system periplasmic component
VV208B2_40200	COG3284	Transcriptional regulator
VV208B2_40210	COG1012	belongs to the aldehyde dehydrogenase family
VV208B2_40230	COG1253	flavin adenine dinucleotide binding
VV208B2_40250	COG0242	peptide deformylase activity
VV208B2_40280	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
VV208B2_40290	COG1609	Transcriptional regulator
VV208B2_40330	COG0488	(ABC) transporter
VV208B2_40340	COG0814	amino acid
VV208B2_40360	COG3033	Beta-eliminating lyase
VV208B2_40380	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VV208B2_40430	COG0189	ligase activity
VV208B2_40430	COG4067	protein conserved in archaea
VV208B2_40440	COG0189	ligase activity
VV208B2_40460	COG1629	transport
VV208B2_40460	COG4774	siderophore transport
VV208B2_40470	COG4607	ABC-type enterochelin transport system periplasmic component
VV208B2_40490	COG1021	2,3-dihydroxybenzoate-AMP ligase
VV208B2_40530	COG1021	2,3-dihydroxybenzoate-AMP ligase
VV208B2_40540	COG1169	isochorismate synthase
VV208B2_40550	COG1028	Short-chain dehydrogenase reductase Sdr
VV208B2_40560	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
VV208B2_40590	COG2977	Belongs to the P-Pant transferase superfamily
VV208B2_40620	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VV208B2_40630	COG0840	transmembrane signaling receptor activity
VV208B2_40650	COG2755	lipolytic protein G-D-S-L family
VV208B2_40660	COG5001	Diguanylate cyclase
VV208B2_40660	COG5002	protein histidine kinase activity
VV208B2_40690	COG4160	amino acid transport
VV208B2_40700	COG4215	(ABC) transporter
VV208B2_40710	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VV208B2_40720	COG1126	abc transporter atp-binding protein
VV208B2_40730	COG3015	lipoprotein NlpE involved in copper resistance
VV208B2_40760	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
VV208B2_40810	COG2814	Major facilitator Superfamily
VV208B2_40860	COG1139	Iron-sulfur cluster binding protein
VV208B2_40880	COG1620	l-lactate permease
VV208B2_40890	COG0583	DNA-binding transcription factor activity
VV208B2_40900	COG1505	serine-type exopeptidase activity
VV208B2_40910	COG4172	Belongs to the ABC transporter superfamily
VV208B2_40930	COG1067	ATP-dependent peptidase activity
VV208B2_40940	COG0402	S-adenosylhomocysteine deaminase activity
VV208B2_40950	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
VV208B2_40970	COG2239	Acts as a magnesium transporter
VV208B2_41020	COG0745	RESPONSE REGULATOR receiver
VV208B2_41030	COG2205	protein histidine kinase activity
VV208B2_41060	COG0121	glutamine amidotransferase
VV208B2_41070	COG0531	amino acid
VV208B2_41080	COG1522	sequence-specific DNA binding
VV208B2_41120	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
VV208B2_41130	COG0583	DNA-binding transcription factor activity
VV208B2_41180	COG5002	protein histidine kinase activity
VV208B2_41180	COG2205	protein histidine kinase activity
VV208B2_41180	COG0784	Response regulator, receiver
VV208B2_41190	COG0534	Mate efflux family protein
VV208B2_41200	COG2926	Belongs to the UPF0265 family
VV208B2_41220	COG3132	Protein of unknown function, DUF480
VV208B2_41230	COG2827	Endonuclease containing a URI domain
VV208B2_41350	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VV208B2_41360	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VV208B2_41380	COG0183	Belongs to the thiolase family
VV208B2_41420	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
VV208B2_41430	COG1940	carbohydrate kinase activity
VV208B2_41440	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
VV208B2_41450	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
VV208B2_41460	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
VV208B2_41470	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
VV208B2_41480	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
VV208B2_41490	COG1737	Transcriptional regulator
VV208B2_41500	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
VV208B2_41510	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
VV208B2_41530	COG3005	denitrification pathway
VV208B2_41550	COG0243	molybdopterin cofactor binding
VV208B2_41570	COG3850	Histidine kinase
VV208B2_41580	COG2197	response regulator
VV208B2_41620	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
VV208B2_41620	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
VV208B2_41640	COG0516	GMP reductase activity
VV208B2_41710	COG0516	GMP reductase activity
VV208B2_41740	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
VV208B2_41770	COG3568	Endonuclease Exonuclease Phosphatase
VV208B2_41820	COG0513	Belongs to the DEAD box helicase family
VV208B2_41840	COG2514	catechol 2,3-dioxygenase activity
VV208B2_41850	COG1846	Transcriptional regulator
VV208B2_41900	COG0842	Transport permease protein
VV208B2_41910	COG1131	(ABC) transporter
VV208B2_41930	COG0837	glucose binding
VV208B2_41930	COG1737	Transcriptional regulator
VV208B2_41950	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
VV208B2_41970	COG4145	pantothenate transmembrane transporter activity
VV208B2_42000	COG0251	oxidation-reduction process
VV208B2_42010	COG5001	Diguanylate cyclase
VV208B2_42010	COG4251	negative regulation of phosphorylation
VV208B2_42010	COG3706	GGDEF domain
VV208B2_42010	COG2203	Gaf domain
VV208B2_42020	COG0583	DNA-binding transcription factor activity
VV208B2_42030	COG2814	Major facilitator Superfamily
VV208B2_42070	COG0697	spore germination
VV208B2_42110	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
VV208B2_42130	COG1764	response to oxidative stress
VV208B2_42140	COG1846	Transcriptional regulator
VV208B2_42190	COG1280	lysine exporter protein (LysE YggA)
VV208B2_42210	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
VV208B2_42220	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
VV208B2_42230	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
VV208B2_42240	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
VV208B2_42280	COG1612	heme a metabolic process
VV208B2_42290	COG0109	protoheme IX farnesyltransferase activity
VV208B2_42300	COG2885	chlorophyll binding
VV208B2_42310	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
VV208B2_42320	COG0840	transmembrane signaling receptor activity
VV208B2_42400	COG2897	thiosulfate sulfurtransferase activity
VV208B2_42410	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
VV208B2_42420	COG0303	'Molybdopterin
VV208B2_42430	COG0302	gtp cyclohydrolase
VV208B2_42440	COG1914	H( )-stimulated, divalent metal cation uptake system
VV208B2_42460	COG0038	chloride channel
VV208B2_42510	COG4989	oxidoreductase activity
VV208B2_42530	COG2195	Cleaves the N-terminal amino acid of tripeptides
VV208B2_42570	COG0840	transmembrane signaling receptor activity
VV208B2_42580	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
VV208B2_42590	COG0545	Peptidyl-prolyl cis-trans isomerase
VV208B2_42660	COG1278	Cold shock
VV208B2_42670	COG3036	rescue of stalled ribosome
VV208B2_42690	COG2203	Gaf domain
VV208B2_42690	COG2199	diguanylate cyclase activity
VV208B2_42700	COG1482	cell wall glycoprotein biosynthetic process
VV208B2_42710	COG2271	Major facilitator Superfamily
VV208B2_42720	COG3851	Histidine kinase
VV208B2_42730	COG2197	response regulator
VV208B2_42770	COG2130	NADP-dependent
VV208B2_42780	COG1309	transcriptional regulator
VV208B2_42820	COG1278	Cold shock
VV208B2_42860	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
VV208B2_42870	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
VV208B2_42880	COG1960	acyl-CoA dehydrogenase activity
VV208B2_42900	COG0183	Belongs to the thiolase family
VV208B2_42920	COG1960	acyl-CoA dehydrogenase activity
VV208B2_42930	COG1024	Enoyl-CoA hydratase
VV208B2_42940	COG1024	Enoyl-CoA hydratase
VV208B2_42960	COG1028	Short-chain dehydrogenase reductase Sdr
VV208B2_43010	COG2994	toxin metabolic process
VV208B2_43020	COG1073	alpha beta
VV208B2_43020	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
VV208B2_43020	COG3064	Membrane
VV208B2_43130	COG0784	Response regulator, receiver
VV208B2_43130	COG3437	response regulator, receiver
VV208B2_43140	COG4191	Histidine kinase
VV208B2_43140	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VV208B2_43160	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
VV208B2_43220	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
VV208B2_43230	COG3186	Phenylalanine-4-hydroxylase
VV208B2_43240	COG2154	pterin-4-alpha-carbinolamine dehydratase
VV208B2_43280	COG3530	Putative quorum-sensing-regulated virulence factor
VV208B2_43320	COG2815	serine threonine protein kinase
VV208B2_43320	COG0515	serine threonine protein kinase
VV208B2_43390	COG0631	protein serine/threonine phosphatase activity
VV208B2_43550	COG3209	COG3209 Rhs family protein
VV208B2_43630	COG0776	regulation of translation
VV208B2_43680	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
VV208B2_43700	COG0653	protein targeting
VV208B2_43710	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
VV208B2_44220	COG3177	Filamentation induced by cAMP protein fic
VV208B2_44510	COG1475	DNA binding
VV208B2_44670	COG0681	Belongs to the peptidase S26 family
VV208B2_44700	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
VV208B2_44850	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
VV208B2_44970	COG4206	TonB-dependent receptor
VV208B2_45080	COG0210	DNA helicase
VV208B2_45190	COG1199	ATP-dependent helicase activity
VV208B2_45570	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
VV208B2_46010	COG2801	Transposase and inactivated derivatives
VV208B2_46050	COG2203	Gaf domain
VV208B2_46050	COG3706	GGDEF domain
VV208B2_46050	COG5001	Diguanylate cyclase
VV208B2_46050	COG4251	negative regulation of phosphorylation
VV208B2_46190	COG2916	Histone family protein nucleoid-structuring protein H-NS
VV208B2_46250	COG2801	Transposase and inactivated derivatives
VV208B2_46300	COG4943	cyclic-guanylate-specific phosphodiesterase activity
VV208B2_46460	COG0338	D12 class N6 adenine-specific DNA methyltransferase
VV208B2_46540	COG0754	glutathionylspermidine amidase activity
VV208B2_46560	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
VV208B2_46750	COG1349	DNA-binding transcription factor activity
VV208B2_46760	COG0561	phosphatase activity
VV208B2_46770	COG0110	maltose O-acetyltransferase activity
VV208B2_46780	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
VV208B2_46820	COG0583	DNA-binding transcription factor activity
VV208B2_46830	COG0697	spore germination
VV208B2_46850	COG0840	transmembrane signaling receptor activity
VV208B2_46880	COG2801	Transposase and inactivated derivatives
VV208B2_46900	COG2205	protein histidine kinase activity
VV208B2_46920	COG2203	Gaf domain
VV208B2_46920	COG3706	GGDEF domain
VV208B2_46920	COG4251	negative regulation of phosphorylation
VV208B2_46920	COG5001	Diguanylate cyclase
VV208B2_46930	COG3300	MHYT domain
VV208B2_46930	COG5001	Diguanylate cyclase
VV208B2_46940	COG4644	lycopene metabolic process
VV208B2_46950	COG4644	lycopene metabolic process
VV208B2_46980	COG3038	cytochrome b561
VV208B2_46990	COG2353	YceI-like domain
VV208B2_47090	COG3385	transposase activity