locus-tag	class	description
F6X00_00025	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
F6X00_00040	COG0583	DNA-binding transcription factor activity
F6X00_00045	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
F6X00_00050	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
F6X00_00055	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
F6X00_00085	COG0484	heat shock protein binding
F6X00_00090	COG0443	Heat shock 70 kDa protein
F6X00_00120	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
F6X00_00125	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
F6X00_00130	COG0497	DNA recombination
F6X00_00135	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
F6X00_00140	COG2914	Belongs to the UPF0125 (RnfH) family
F6X00_00145	COG2867	negative regulation of translational initiation
F6X00_00150	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
F6X00_00160	COG0582	viral genome integration into host DNA
F6X00_00185	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
F6X00_00280	COG0009	L-threonylcarbamoyladenylate synthase
F6X00_00300	COG0583	DNA-binding transcription factor activity
F6X00_00310	COG1115	amino acid carrier protein
F6X00_00315	COG1584	GPR1 FUN34 yaaH family protein
F6X00_00325	COG0519	Catalyzes the synthesis of GMP from XMP
F6X00_00325	COG0518	GMP synthase (glutamine-hydrolyzing) activity
F6X00_00330	COG0516	GMP reductase activity
F6X00_00330	COG0517	IMP dehydrogenase activity
F6X00_00345	COG2203	Gaf domain
F6X00_00345	COG2199	diguanylate cyclase activity
F6X00_00355	COG1160	GTP binding
F6X00_00360	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
F6X00_00365	COG2976	Protein conserved in bacteria
F6X00_00370	COG0124	histidyl-tRNA synthetase
F6X00_00375	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
F6X00_00385	COG0820	rRNA (adenine-C2-)-methyltransferase activity
F6X00_00390	COG0105	UTP biosynthetic process
F6X00_00395	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
F6X00_00400	COG2975	iron-sulfur cluster assembly
F6X00_00405	COG0633	Ferredoxin
F6X00_00410	COG0443	Heat shock 70 kDa protein
F6X00_00420	COG0316	Belongs to the HesB IscA family
F6X00_00425	COG0822	iron-sulfur transferase activity
F6X00_00435	COG1959	2 iron, 2 sulfur cluster binding
F6X00_00440	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
F6X00_00445	COG0483	inositol monophosphate 1-phosphatase activity
F6X00_00450	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
F6X00_00455	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
F6X00_00460	COG1862	Preprotein translocase
F6X00_00465	COG0343	queuine tRNA-ribosyltransferase activity
F6X00_00470	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
F6X00_00480	COG0517	IMP dehydrogenase activity
F6X00_00490	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
F6X00_00495	COG0583	DNA-binding transcription factor activity
F6X00_00500	COG0450	alkyl hydroperoxide reductase
F6X00_00525	COG0704	Plays a role in the regulation of phosphate uptake
F6X00_00530	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
F6X00_00535	COG0581	inorganic phosphate transmembrane transporter activity
F6X00_00540	COG0573	inorganic phosphate transmembrane transporter activity
F6X00_00550	COG0248	Ppx GppA phosphatase
F6X00_00560	COG5002	protein histidine kinase activity
F6X00_00565	COG0745	RESPONSE REGULATOR receiver
F6X00_00580	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
F6X00_00620	COG0542	response to heat
F6X00_00635	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
F6X00_00645	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
F6X00_00650	COG0077	Prephenate dehydratase
F6X00_00650	COG1605	Chorismate mutase
F6X00_00655	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
F6X00_00660	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
F6X00_00670	COG0488	(ABC) transporter
F6X00_00680	COG0739	heme binding
F6X00_00685	COG1605	Chorismate mutase
F6X00_00685	COG0287	Prephenate dehydrogenase
F6X00_00700	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
F6X00_00720	COG1966	Carbon starvation protein
F6X00_00725	COG3275	phosphorelay sensor kinase activity
F6X00_00735	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
F6X00_00740	COG1047	Peptidyl-prolyl cis-trans
F6X00_00745	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
F6X00_00750	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
F6X00_00755	COG0196	riboflavin kinase activity
F6X00_00760	COG0728	peptidoglycan biosynthetic process
F6X00_00765	COG0268	Binds directly to 16S ribosomal RNA
F6X00_00770	COG0640	Transcriptional regulator
F6X00_00775	COG0583	DNA-binding transcription factor activity
F6X00_00780	COG1283	sodium-dependent phosphate transmembrane transporter activity
F6X00_00800	COG0730	response to heat
F6X00_00810	COG0494	nUDIX hydrolase
F6X00_00815	COG3066	DNA modification
F6X00_00825	COG0667	Aldo Keto reductase
F6X00_00840	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
F6X00_00850	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
F6X00_00855	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
F6X00_00860	COG4974	Belongs to the 'phage' integrase family
F6X00_00880	COG0513	Belongs to the DEAD box helicase family
F6X00_00890	COG1115	amino acid carrier protein
F6X00_00905	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
F6X00_00915	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
F6X00_00920	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
F6X00_00925	COG0083	homoserine kinase activity
F6X00_00940	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
F6X00_00955	COG0745	RESPONSE REGULATOR receiver
F6X00_00965	COG0784	Response regulator, receiver
F6X00_00965	COG2198	Histidine kinase
F6X00_00965	COG5002	protein histidine kinase activity
F6X00_00970	COG5001	Diguanylate cyclase
F6X00_00970	COG4251	negative regulation of phosphorylation
F6X00_00970	COG2203	Gaf domain
F6X00_00970	COG3706	GGDEF domain
F6X00_00975	COG1242	4 iron, 4 sulfur cluster binding
F6X00_00980	COG0070	glutamate synthase
F6X00_00980	COG0069	glutamate synthase activity
F6X00_00980	COG0067	glutamate synthase
F6X00_00990	COG0069	glutamate synthase activity
F6X00_00990	COG0070	glutamate synthase
F6X00_00990	COG0067	glutamate synthase
F6X00_00995	COG0493	'glutamate synthase
F6X00_01005	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
F6X00_01020	COG2860	membrane
F6X00_01025	COG0583	DNA-binding transcription factor activity
F6X00_01030	COG0730	response to heat
F6X00_01040	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
F6X00_01045	COG0505	Belongs to the CarA family
F6X00_01055	COG0494	nUDIX hydrolase
F6X00_01060	COG0653	protein targeting
F6X00_01070	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
F6X00_01075	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
F6X00_01080	COG0849	cell division
F6X00_01085	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
F6X00_01090	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
F6X00_01100	COG0772	Belongs to the SEDS family
F6X00_01105	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
F6X00_01110	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
F6X00_01115	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
F6X00_01125	COG0768	penicillin binding
F6X00_01130	COG3116	cell division
F6X00_01135	COG0275	rRNA processing
F6X00_01145	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
F6X00_01150	COG3107	peptidoglycan biosynthetic process
F6X00_01155	COG0792	nuclease activity
F6X00_01160	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
F6X00_01165	COG2823	Periplasmic or secreted lipoprotein
F6X00_01170	COG2969	positive regulation of protein catabolic process
F6X00_01175	COG0625	glutathione transferase activity
F6X00_01180	COG2857	Cytochrome c1
F6X00_01185	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
F6X00_01190	COG0723	plastoquinol--plastocyanin reductase activity
F6X00_01195	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
F6X00_01200	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
F6X00_01210	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
F6X00_01215	COG3105	Protein conserved in bacteria
F6X00_01220	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
F6X00_01225	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
F6X00_01240	COG3150	esterase
F6X00_01250	COG3151	Protein conserved in bacteria
F6X00_01255	COG0494	nUDIX hydrolase
F6X00_01260	COG1538	Outer membrane efflux protein
F6X00_01270	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
F6X00_01280	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
F6X00_01285	COG3025	triphosphatase activity
F6X00_01290	COG1392	Phosphate transport regulator
F6X00_01295	COG0306	phosphate transporter
F6X00_01300	COG4991	sh3 domain protein
F6X00_01305	COG3409	Peptidoglycan-binding domain 1 protein
F6X00_01305	COG3267	Type II secretory pathway component ExeA
F6X00_01310	COG0617	tRNA 3'-terminal CCA addition
F6X00_01315	COG1968	undecaprenyl-diphosphatase activity
F6X00_01320	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
F6X00_01325	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
F6X00_01335	COG0596	Alpha beta hydrolase
F6X00_01340	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
F6X00_01345	COG0828	Belongs to the bacterial ribosomal protein bS21 family
F6X00_01350	COG1610	YqeY-like protein
F6X00_01370	COG0582	viral genome integration into host DNA
F6X00_01410	COG3339	Conserved Protein
F6X00_01425	COG2003	Belongs to the UPF0758 family
F6X00_01430	COG3547	Transposase (IS116 IS110 IS902 family)
F6X00_01515	COG1181	Belongs to the D-alanine--D-alanine ligase family
F6X00_01570	COG3501	Rhs element vgr protein
F6X00_01585	COG2207	Transcriptional regulator
F6X00_01605	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
F6X00_01610	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
F6X00_01610	COG2213	PTS system mannitol-specific
F6X00_01615	COG0246	Mannitol dehydrogenase
F6X00_01620	COG3722	fumarate hydratase activity
F6X00_01625	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
F6X00_01630	COG1349	DNA-binding transcription factor activity
F6X00_01645	COG3706	GGDEF domain
F6X00_01650	COG0440	acetolactate synthase activity
F6X00_01655	COG0028	Belongs to the TPP enzyme family
F6X00_01660	COG1022	Amp-dependent synthetase and ligase
F6X00_01685	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
F6X00_01690	COG0473	3-isopropylmalate dehydrogenase activity
F6X00_01715	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
F6X00_01725	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
F6X00_01730	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
F6X00_01735	COG2967	ApaG domain
F6X00_01750	COG3610	response to peptide
F6X00_01755	COG2966	Psort location CytoplasmicMembrane, score
F6X00_01765	COG0211	Belongs to the bacterial ribosomal protein bL27 family
F6X00_01770	COG0261	This protein binds to 23S rRNA in the presence of protein L20
F6X00_01775	COG0142	geranyltranstransferase activity
F6X00_01780	COG0039	L-malate dehydrogenase activity
F6X00_01785	COG1438	arginine binding
F6X00_01790	COG2358	TRAP transporter, solute receptor (TAXI family
F6X00_01800	COG0589	response to stress
F6X00_01805	COG0204	Acyl-transferase
F6X00_01810	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
F6X00_01815	COG5007	Belongs to the BolA IbaG family
F6X00_01825	COG2854	intermembrane phospholipid transfer
F6X00_01830	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
F6X00_01835	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
F6X00_01840	COG1127	ABC transporter
F6X00_01850	COG0517	IMP dehydrogenase activity
F6X00_01850	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
F6X00_01855	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
F6X00_01865	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
F6X00_01870	COG1137	ATPase activity
F6X00_01880	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
F6X00_01885	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
F6X00_01890	COG1660	Displays ATPase and GTPase activities
F6X00_01895	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
F6X00_01900	COG2239	Acts as a magnesium transporter
F6X00_01905	COG0312	modulator of DNA gyrase
F6X00_01910	COG3028	Belongs to the UPF0307 family
F6X00_01915	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
F6X00_01920	COG1178	ABC-type Fe3 transport system permease component
F6X00_01925	COG4143	(ABC) transporter
F6X00_01930	COG0163	prenyltransferase activity
F6X00_01935	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
F6X00_01940	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
F6X00_01945	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
F6X00_01955	COG2105	PFAM AIG2 family protein
F6X00_01960	COG2911	Protein conserved in bacteria
F6X00_01965	COG0729	surface antigen
F6X00_01980	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
F6X00_01995	COG0577	efflux transmembrane transporter activity
F6X00_01995	COG1136	(ABC) transporter
F6X00_02015	COG0529	Catalyzes the synthesis of activated sulfate
F6X00_02020	COG0471	metal ion transport
F6X00_02020	COG3273	potassium ion transport
F6X00_02030	COG0175	sulfate reduction
F6X00_02035	COG1648	precorrin-2 dehydrogenase activity
F6X00_02035	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
F6X00_02040	COG0737	Belongs to the 5'-nucleotidase family
F6X00_02050	COG2153	protein acetylation
F6X00_02060	COG3266	domain, Protein
F6X00_02060	COG3061	Opacity-associated protein A
F6X00_02065	COG0545	Peptidyl-prolyl cis-trans isomerase
F6X00_02075	COG0203	ribosomal protein L17
F6X00_02080	COG0202	RNA polymerase activity
F6X00_02085	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
F6X00_02090	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
F6X00_02095	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
F6X00_02100	COG0257	Belongs to the bacterial ribosomal protein bL36 family
F6X00_02105	COG0201	protein transport
F6X00_02110	COG0200	Binds to the 23S rRNA
F6X00_02115	COG1841	ribosomal large subunit assembly
F6X00_02120	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
F6X00_02125	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
F6X00_02130	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
F6X00_02135	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
F6X00_02140	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
F6X00_02145	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
F6X00_02150	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
F6X00_02155	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
F6X00_02160	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
F6X00_02165	COG0255	Belongs to the universal ribosomal protein uL29 family
F6X00_02170	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
F6X00_02175	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
F6X00_02185	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
F6X00_02190	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
F6X00_02195	COG0089	rRNA binding
F6X00_02200	COG0088	Forms part of the polypeptide exit tunnel
F6X00_02220	COG3064	Membrane
F6X00_02270	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
F6X00_02280	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
F6X00_02325	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
F6X00_02330	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
F6X00_02350	COG1596	polysaccharide export
F6X00_02395	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
F6X00_02410	COG0859	PFAM glycosyl transferase family 9
F6X00_02415	COG1519	Transferase
F6X00_02425	COG2089	acid synthase
F6X00_02435	COG1083	cytidylyl-transferase
F6X00_02440	COG0107	imidazoleglycerol-phosphate synthase activity
F6X00_02445	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
F6X00_02455	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
F6X00_02460	COG1086	Polysaccharide biosynthesis protein
F6X00_02475	COG3083	sulfuric ester hydrolase activity
F6X00_02480	COG3642	lipopolysaccharide core region biosynthetic process
F6X00_02485	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
F6X00_02490	COG0859	PFAM glycosyl transferase family 9
F6X00_02495	COG0463	Glycosyl transferase, family 2
F6X00_02500	COG0859	PFAM glycosyl transferase family 9
F6X00_02505	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
F6X00_02525	COG0267	Belongs to the bacterial ribosomal protein bL33 family
F6X00_02530	COG0227	Belongs to the bacterial ribosomal protein bL28 family
F6X00_02535	COG2003	Belongs to the UPF0758 family
F6X00_02550	COG1309	transcriptional regulator
F6X00_02555	COG1560	Kdo2-lipid A biosynthetic process
F6X00_02565	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
F6X00_02570	COG1561	YicC-like family, N-terminal region
F6X00_02595	COG4608	Belongs to the ABC transporter superfamily
F6X00_02600	COG0444	Belongs to the ABC transporter superfamily
F6X00_02605	COG0747	negative chemotaxis
F6X00_02610	COG4239	(ABC) transporter, permease
F6X00_02615	COG4174	ABC transporter (Permease)
F6X00_02620	COG4206	TonB-dependent receptor
F6X00_02630	COG0811	peptide transport
F6X00_02635	COG0811	peptide transport
F6X00_02640	COG0848	biopolymer transport protein
F6X00_02655	COG0194	GDP metabolic process
F6X00_02660	COG1758	RNA polymerase activity
F6X00_02665	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
F6X00_02670	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
F6X00_02675	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
F6X00_02680	COG2233	PERMEase
F6X00_02690	COG0745	RESPONSE REGULATOR receiver
F6X00_02695	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
F6X00_02700	COG2183	response to ionizing radiation
F6X00_02710	COG0596	Alpha beta hydrolase
F6X00_02715	COG1040	competence protein
F6X00_02720	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
F6X00_02720	COG0316	Belongs to the HesB IscA family
F6X00_02725	COG0494	nUDIX hydrolase
F6X00_02730	COG1218	3'(2'),5'-bisphosphate nucleotidase
F6X00_02740	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
F6X00_02745	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
F6X00_02750	COG3156	type II secretion system protein K
F6X00_02755	COG4795	General secretion pathway protein
F6X00_02760	COG2165	general secretion pathway protein
F6X00_02765	COG2165	general secretion pathway protein
F6X00_02770	COG2165	general secretion pathway protein
F6X00_02775	COG1459	type II secretion system
F6X00_02780	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
F6X00_02790	COG3031	protein transport across the cell outer membrane
F6X00_02795	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
F6X00_02800	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
F6X00_02815	COG0456	acetyltransferase
F6X00_02820	COG1490	D-aminoacyl-tRNA deacylase activity
F6X00_02825	COG1295	ribonuclease BN
F6X00_02850	COG0174	glutamine synthetase
F6X00_02860	COG3852	Histidine kinase
F6X00_02865	COG2204	response regulator
F6X00_02870	COG3300	MHYT domain
F6X00_02870	COG5001	Diguanylate cyclase
F6X00_02885	COG3078	GTPase activator activity
F6X00_02905	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
F6X00_02905	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
F6X00_02915	COG0084	hydrolase, TatD family'
F6X00_02920	COG0805	protein transport
F6X00_02925	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
F6X00_02945	COG2226	methyltransferase
F6X00_02950	COG1322	Protein conserved in bacteria
F6X00_03065	COG3118	belongs to the thioredoxin family
F6X00_03075	COG0248	Ppx GppA phosphatase
F6X00_03080	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
F6X00_03095	COG0514	ATP-dependent DNA helicase (RecQ)
F6X00_03100	COG2962	Rard protein
F6X00_03110	COG1280	lysine exporter protein (LysE YggA)
F6X00_03120	COG0210	DNA helicase
F6X00_03160	COG0006	proline dipeptidase activity
F6X00_03160	COG0006	proline dipeptidase activity
F6X00_03170	COG2022	thiamine diphosphate biosynthetic process
F6X00_03180	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
F6X00_03190	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
F6X00_03195	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
F6X00_03200	COG2132	Multicopper oxidase
F6X00_03235	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
F6X00_03245	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
F6X00_03250	COG0408	coproporphyrinogen oxidase activity
F6X00_03255	COG0009	L-threonylcarbamoyladenylate synthase
F6X00_03260	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
F6X00_03270	COG0551	DNA topoisomerase type I activity
F6X00_03275	COG2922	Belongs to the Smg family
F6X00_03280	COG0758	DNA mediated transformation
F6X00_03290	COG0242	peptide deformylase activity
F6X00_03295	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
F6X00_03300	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
F6X00_03300	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
F6X00_03305	COG0569	domain protein
F6X00_03310	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
F6X00_03315	COG1272	protein, Hemolysin III
F6X00_03320	COG4326	sporulation control protein
F6X00_03325	COG3084	Protein conserved in bacteria
F6X00_03335	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
F6X00_03340	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
F6X00_03345	COG0204	Acyl-transferase
F6X00_03380	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
F6X00_03400	COG3978	acetolactate synthase activity
F6X00_03405	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
F6X00_03410	COG0129	dihydroxy-acid dehydratase activity
F6X00_03420	COG0583	DNA-binding transcription factor activity
F6X00_03425	COG2814	Major facilitator Superfamily
F6X00_03435	COG0765	amino acid transport
F6X00_03440	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
F6X00_03445	COG0355	proton-transporting ATP synthase activity, rotational mechanism
F6X00_03450	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
F6X00_03455	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
F6X00_03460	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
F6X00_03465	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
F6X00_03470	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
F6X00_03480	COG0356	it plays a direct role in the translocation of protons across the membrane
F6X00_03485	COG3312	ion transport
F6X00_03490	COG1475	DNA binding
F6X00_03495	COG1192	Involved in chromosome partitioning
F6X00_03500	COG0357	Ribosomal RNA small subunit methyltransferase G
F6X00_03505	COG0445	tRNA wobble uridine modification
F6X00_03510	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
F6X00_03520	COG0706	membrane insertase activity
F6X00_03530	COG0594	ribonuclease P activity
F6X00_03535	COG0230	Belongs to the bacterial ribosomal protein bL34 family
F6X00_03540	COG1126	abc transporter atp-binding protein
F6X00_03560	COG0592	DNA-directed DNA polymerase activity
F6X00_03570	COG0187	DNA topoisomerase II activity
F6X00_03575	COG0071	Belongs to the small heat shock protein (HSP20) family
F6X00_03585	COG3977	Valine--pyruvate aminotransferase
F6X00_03595	COG0752	glycyl-tRNA synthetase alpha subunit
F6X00_03600	COG2119	membrane
F6X00_03610	COG0425	Belongs to the sulfur carrier protein TusA family
F6X00_03625	COG0604	alcohol dehydrogenase
F6X00_03630	COG0183	Belongs to the thiolase family
F6X00_03640	COG1739	Uncharacterized protein family UPF0029
F6X00_03645	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
F6X00_03695	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
F6X00_03700	COG2960	long-chain fatty acid transporting porin activity
F6X00_03705	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
F6X00_03710	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F6X00_03715	COG1309	transcriptional regulator
F6X00_03755	COG4172	Belongs to the ABC transporter superfamily
F6X00_03760	COG4166	transmembrane transport
F6X00_03770	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F6X00_03805	COG2815	serine threonine protein kinase
F6X00_03805	COG0515	serine threonine protein kinase
F6X00_03815	COG0745	RESPONSE REGULATOR receiver
F6X00_03820	COG1609	Transcriptional regulator
F6X00_03825	COG0129	dihydroxy-acid dehydratase activity
F6X00_03830	COG3265	gluconokinase activity
F6X00_03835	COG2610	gluconate transmembrane transporter activity
F6X00_03840	COG0800	Aldolase
F6X00_03845	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
F6X00_03850	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
F6X00_03860	COG1522	sequence-specific DNA binding
F6X00_03865	COG5002	protein histidine kinase activity
F6X00_03865	COG5001	Diguanylate cyclase
F6X00_03870	COG0742	ribosomal rna small subunit methyltransferase
F6X00_03890	COG1528	Iron-storage protein
F6X00_03900	COG2081	HI0933 family
F6X00_03910	COG2959	enzyme of heme biosynthesis
F6X00_03920	COG0181	hydroxymethylbilane synthase activity
F6X00_03925	COG3072	Adenylate cyclase
F6X00_03930	COG1965	Belongs to the frataxin family
F6X00_03940	COG0019	diaminopimelate decarboxylase activity
F6X00_03945	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
F6X00_03955	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
F6X00_03960	COG1011	Hydrolase
F6X00_03965	COG3287	FIST C domain
F6X00_03965	COG2199	diguanylate cyclase activity
F6X00_03965	COG2200	EAL domain
F6X00_03985	COG0561	phosphatase activity
F6X00_03990	COG2267	carboxylic ester hydrolase activity
F6X00_03995	COG1280	lysine exporter protein (LysE YggA)
F6X00_04000	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
F6X00_04005	COG0640	Transcriptional regulator
F6X00_04010	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
F6X00_04055	COG2095	MarC family integral membrane protein
F6X00_04065	COG0742	ribosomal rna small subunit methyltransferase
F6X00_04070	COG0552	protein localization to endoplasmic reticulum
F6X00_04075	COG2884	Cell division ATP-binding protein ftsE
F6X00_04080	COG2177	Part of the ABC transporter FtsEX involved in
F6X00_04090	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
F6X00_04095	COG0705	Rhomboid family
F6X00_04100	COG1580	Controls the rotational direction of flagella during chemotaxis
F6X00_04115	COG2937	Belongs to the GPAT DAPAT family
F6X00_04125	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
F6X00_04135	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
F6X00_04180	COG0328	RNA-DNA hybrid ribonuclease activity
F6X00_04190	COG0583	DNA-binding transcription factor activity
F6X00_04225	COG3626	phosphonate metabolism
F6X00_04230	COG3627	carbon phosphorus lyase activity
F6X00_04235	COG4107	phosphonate C-P lyase system protein PhnK
F6X00_04240	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
F6X00_04245	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
F6X00_04290	COG2003	Belongs to the UPF0758 family
F6X00_04315	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
F6X00_04345	COG0789	Transcriptional regulator
F6X00_04360	COG1566	PFAM secretion protein HlyD family protein
F6X00_04380	COG0784	Response regulator, receiver
F6X00_04380	COG2205	protein histidine kinase activity
F6X00_04440	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
F6X00_04455	COG0346	lactoylglutathione lyase activity
F6X00_04470	COG0371	Dehydrogenase
F6X00_04475	COG4932	domain protein
F6X00_04475	COG5492	domain, Protein
F6X00_04495	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
F6X00_04510	COG4206	TonB-dependent receptor
F6X00_04600	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
F6X00_04610	COG0812	UDP-N-acetylmuramate dehydrogenase activity
F6X00_04620	COG1072	(Pantothenic acid kinase))
F6X00_04645	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
F6X00_04650	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
F6X00_04665	COG0081	regulation of translation
F6X00_04670	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
F6X00_04675	COG0222	ribosome binding
F6X00_04680	COG0085	RNA polymerase activity
F6X00_04685	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
F6X00_04690	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
F6X00_04710	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
F6X00_04715	COG1573	uracil-dna glycosylase
F6X00_04720	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
F6X00_04725	COG3068	Protein conserved in bacteria
F6X00_04730	COG1253	flavin adenine dinucleotide binding
F6X00_04745	COG0151	Belongs to the GarS family
F6X00_04750	COG0138	bifunctional purine biosynthesis protein purh
F6X00_04755	COG0789	Transcriptional regulator
F6X00_04760	COG0840	transmembrane signaling receptor activity
F6X00_04765	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
F6X00_04780	COG0439	Biotin carboxylase
F6X00_04785	COG0511	ligase activity, forming carbon-carbon bonds
F6X00_04790	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
F6X00_04795	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
F6X00_04810	COG2814	Major facilitator Superfamily
F6X00_04815	COG2205	protein histidine kinase activity
F6X00_04815	COG2198	Histidine kinase
F6X00_04815	COG0784	Response regulator, receiver
F6X00_04830	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
F6X00_04840	COG2095	MarC family integral membrane protein
F6X00_04850	COG4232	protein-disulfide reductase activity
F6X00_04855	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
F6X00_04860	COG1027	Aspartate ammonia-lyase
F6X00_04870	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
F6X00_04880	COG2205	protein histidine kinase activity
F6X00_04885	COG0745	RESPONSE REGULATOR receiver
F6X00_04900	COG0205	6-phosphofructokinase activity
F6X00_04905	COG0534	Mate efflux family protein
F6X00_04910	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
F6X00_04915	COG0459	protein refolding
F6X00_04925	COG1285	pathogenesis
F6X00_04930	COG1509	lysine 2,3-aminomutase activity
F6X00_04935	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
F6X00_04950	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
F6X00_04955	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
F6X00_04960	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
F6X00_04965	COG1053	succinate dehydrogenase
F6X00_04970	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
F6X00_04990	COG4942	peptidase
F6X00_04995	COG1045	serine acetyltransferase
F6X00_05000	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
F6X00_05005	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
F6X00_05010	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
F6X00_05020	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
F6X00_05030	COG0471	metal ion transport
F6X00_05035	COG0688	phosphatidylethanolamine metabolic process
F6X00_05040	COG1162	GTPase activity
F6X00_05045	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
F6X00_05110	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
F6X00_05115	COG0802	atpase or kinase
F6X00_05120	COG0860	N-Acetylmuramoyl-L-alanine amidase
F6X00_05135	COG1923	regulation of RNA biosynthetic process
F6X00_05140	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
F6X00_05145	COG0330	HflC and HflK could
F6X00_05150	COG0330	HflC and HflK could
F6X00_05155	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
F6X00_05160	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
F6X00_05165	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
F6X00_05175	COG1959	2 iron, 2 sulfur cluster binding
F6X00_05180	COG0402	S-adenosylhomocysteine deaminase activity
F6X00_05185	COG0557	exoribonuclease II activity
F6X00_05190	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
F6X00_05220	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
F6X00_05230	COG1012	belongs to the aldehyde dehydrogenase family
F6X00_05240	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
F6X00_05245	COG3954	Phosphoribulokinase
F6X00_05250	COG3089	Belongs to the UPF0270 family
F6X00_05255	COG0429	hydrolase of the alpha beta-hydrolase fold
F6X00_05265	COG0488	(ABC) transporter
F6X00_05270	COG2249	NAD(P)H dehydrogenase (quinone) activity
F6X00_05285	COG1047	Peptidyl-prolyl cis-trans
F6X00_05295	COG2900	Belongs to the SlyX family
F6X00_05305	COG0545	Peptidyl-prolyl cis-trans isomerase
F6X00_05310	COG2964	Protein conserved in bacteria
F6X00_05320	COG2923	Belongs to the DsrF TusC family
F6X00_05325	COG2168	tRNA wobble position uridine thiolation
F6X00_05330	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
F6X00_05335	COG0049	tRNA binding
F6X00_05340	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
F6X00_05350	COG2906	2 iron, 2 sulfur cluster binding
F6X00_05360	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
F6X00_05365	COG0149	triose-phosphate isomerase activity
F6X00_05390	COG1494	fructose-1,6-bisphosphatase
F6X00_05395	COG3074	FtsZ-dependent cytokinesis
F6X00_05405	COG1575	Belongs to the MenA family. Type 1 subfamily
F6X00_05410	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
F6X00_05415	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
F6X00_05425	COG1609	Transcriptional regulator
F6X00_05430	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
F6X00_05435	COG0254	rRNA binding
F6X00_05440	COG0281	malic enzyme
F6X00_05445	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
F6X00_05450	COG0626	cystathionine gamma-synthase activity
F6X00_05455	COG0527	aspartate kinase activity
F6X00_05455	COG0460	homoserine dehydrogenase
F6X00_05460	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
F6X00_05470	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
F6X00_05475	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
F6X00_05490	COG0137	argininosuccinate synthase activity
F6X00_05495	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
F6X00_05495	COG0165	Argininosuccinate lyase
F6X00_05510	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
F6X00_05540	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
F6X00_05545	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
F6X00_05555	COG0338	D12 class N6 adenine-specific DNA methyltransferase
F6X00_05560	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
F6X00_05565	COG0360	Binds together with S18 to 16S ribosomal RNA
F6X00_05570	COG2965	DNA replication, synthesis of RNA primer
F6X00_05580	COG0359	binds to the 23S rRNA
F6X00_05595	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
F6X00_05650	COG0556	nucleotide-excision repair
F6X00_05665	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
F6X00_05700	COG0735	belongs to the Fur family
F6X00_05730	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
F6X00_05810	COG1410	methionine synthase
F6X00_05810	COG0646	methionine synthase
F6X00_05815	COG0527	aspartate kinase activity
F6X00_05825	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
F6X00_05855	COG2199	diguanylate cyclase activity
F6X00_05855	COG2200	EAL domain
F6X00_05880	COG3267	Type II secretory pathway component ExeA
F6X00_05880	COG3409	Peptidoglycan-binding domain 1 protein
F6X00_05890	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
F6X00_05895	COG1459	type II secretion system
F6X00_05940	COG1077	Cell shape determining protein MreB Mrl
F6X00_05945	COG1792	Involved in formation and maintenance of cell shape
F6X00_05950	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
F6X00_05955	COG0424	maF-like protein
F6X00_05960	COG1530	ribonuclease E activity
F6X00_05965	COG3164	Protein of unknown function
F6X00_05970	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
F6X00_05975	COG0312	modulator of DNA gyrase
F6X00_05980	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
F6X00_05995	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
F6X00_06000	COG0251	oxidation-reduction process
F6X00_06005	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
F6X00_06020	COG2235	arginine
F6X00_06110	COG0456	acetyltransferase
F6X00_06120	COG4269	membrane
F6X00_06130	COG0525	valine-tRNA ligase activity
F6X00_06135	COG2927	DNA polymerase III (CHI subunit)
F6X00_06140	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
F6X00_06145	COG0795	lipopolysaccharide-transporting ATPase activity
F6X00_06150	COG0795	lipopolysaccharide-transporting ATPase activity
F6X00_06165	COG0726	polysaccharide deacetylase
F6X00_06170	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
F6X00_06180	COG1447	Phosphotransferase system cellobiose-specific component IIA
F6X00_06185	COG1486	melibiose metabolic process
F6X00_06195	COG1609	Transcriptional regulator
F6X00_06205	COG3437	response regulator, receiver
F6X00_06315	COG0741	lytic transglycosylase activity
F6X00_06320	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
F6X00_06330	COG0220	tRNA (guanine-N7-)-methyltransferase activity
F6X00_06335	COG2066	Belongs to the glutaminase family
F6X00_06345	COG0635	Involved in the biosynthesis of porphyrin-containing compound
F6X00_06350	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
F6X00_06360	COG1872	DUF167
F6X00_06365	COG0762	integral membrane protein
F6X00_06370	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
F6X00_06375	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
F6X00_06390	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
F6X00_06395	COG1678	Uncharacterized ACR, COG1678
F6X00_06405	COG1385	rRNA (uridine-N3-)-methyltransferase activity
F6X00_06415	COG2356	endonuclease I
F6X00_06430	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
F6X00_06435	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
F6X00_06450	COG0126	phosphoglycerate kinase activity
F6X00_06455	COG0191	fructose-bisphosphate aldolase activity
F6X00_06460	COG0668	transmembrane transport
F6X00_06465	COG1279	arginine transmembrane transporter activity
F6X00_06480	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
F6X00_06485	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
F6X00_06490	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
F6X00_06500	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
F6X00_06505	COG3079	Belongs to the UPF0149 family
F6X00_06510	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
F6X00_06515	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
F6X00_06530	COG0354	folic acid binding
F6X00_06545	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
F6X00_06550	COG1595	DNA-templated transcription, initiation
F6X00_06565	COG3086	response to oxidative stress
F6X00_06570	COG0481	GTPase activity
F6X00_06580	COG0571	ribonuclease III activity
F6X00_06585	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
F6X00_06590	COG1381	Involved in DNA repair and RecF pathway recombination
F6X00_06595	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
F6X00_06620	COG4999	Histidine kinase
F6X00_06620	COG2205	protein histidine kinase activity
F6X00_06620	COG3850	Histidine kinase
F6X00_06620	COG3437	response regulator, receiver
F6X00_06625	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
F6X00_06630	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
F6X00_06635	COG3956	TIGRFAM MazG family protein
F6X00_06640	COG0504	CTP synthase activity
F6X00_06650	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
F6X00_06660	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
F6X00_06675	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
F6X00_06680	COG4942	peptidase
F6X00_06680	COG1388	LysM domain
F6X00_06685	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
F6X00_06690	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
F6X00_06700	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
F6X00_06705	COG2137	regulation of response to DNA damage stimulus
F6X00_06710	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
F6X00_06715	COG0527	aspartate kinase activity
F6X00_06720	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
F6X00_06765	COG3630	sodium ion export across plasma membrane
F6X00_06770	COG5016	pyruvate
F6X00_06770	COG0511	ligase activity, forming carbon-carbon bonds
F6X00_06775	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
F6X00_06785	COG1238	metal cluster binding
F6X00_06790	COG0612	Peptidase, M16
F6X00_06795	COG2918	glutathione biosynthetic process
F6X00_06805	COG1854	S-ribosylhomocysteine lyase activity
F6X00_06810	COG4536	flavin adenine dinucleotide binding
F6X00_06815	COG4137	Cytochrome C assembly protein
F6X00_06820	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
F6X00_06825	COG0228	four-way junction DNA binding
F6X00_06830	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
F6X00_06835	COG0336	Belongs to the RNA methyltransferase TrmD family
F6X00_06840	COG0335	large ribosomal subunit rRNA binding
F6X00_06845	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
F6X00_06865	COG1459	type II secretion system
F6X00_06870	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
F6X00_06880	COG0157	Belongs to the NadC ModD family
F6X00_06885	COG3023	N-Acetylmuramoyl-L-alanine amidase
F6X00_06890	COG2186	Transcriptional regulator
F6X00_06895	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
F6X00_06900	COG0508	dehydrogenase complex catalyzes the overall conversion of
F6X00_06905	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
F6X00_06920	COG0288	reversible hydration of carbon dioxide
F6X00_06925	COG0659	secondary active sulfate transmembrane transporter activity
F6X00_06930	COG1131	(ABC) transporter
F6X00_06935	COG0842	Transport permease protein
F6X00_06945	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
F6X00_06950	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
F6X00_06960	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
F6X00_06965	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
F6X00_06970	COG1489	DNA binding
F6X00_06975	COG1643	Atp-dependent helicase
F6X00_06980	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
F6X00_06985	COG1752	Esterase of the alpha-beta hydrolase superfamily
F6X00_06990	COG1049	propionate catabolic process, 2-methylcitrate cycle
F6X00_06995	COG1929	Belongs to the glycerate kinase type-1 family
F6X00_07000	COG2610	gluconate transmembrane transporter activity
F6X00_07005	COG3835	regulator
F6X00_07010	COG3112	Uncharacterised protein family (UPF0231)
F6X00_07015	COG0347	Belongs to the P(II) protein family
F6X00_07020	COG0004	ammonium transporteR
F6X00_07025	COG1840	ABC-type Fe3 transport system, periplasmic component
F6X00_07040	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
F6X00_07055	COG2971	BadF BadG BcrA BcrD
F6X00_07065	COG4608	Belongs to the ABC transporter superfamily
F6X00_07070	COG0444	Belongs to the ABC transporter superfamily
F6X00_07075	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F6X00_07080	COG0601	transmembrane transport
F6X00_07090	COG2205	protein histidine kinase activity
F6X00_07090	COG0784	Response regulator, receiver
F6X00_07095	COG2813	Specifically methylates the guanine in position
F6X00_07100	COG0628	permease
F6X00_07110	COG0316	Belongs to the HesB IscA family
F6X00_07125	COG0739	heme binding
F6X00_07130	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
F6X00_07135	COG2832	Protein of unknown function (DUF454)
F6X00_07140	COG2027	D-alanyl-D-alanine carboxypeptidase
F6X00_07145	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
F6X00_07155	COG1534	Rna-binding protein
F6X00_07160	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
F6X00_07165	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
F6X00_07170	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
F6X00_07175	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
F6X00_07180	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
F6X00_07195	COG0779	Required for maturation of 30S ribosomal subunits
F6X00_07200	COG0195	Participates in both transcription termination and antitermination
F6X00_07205	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
F6X00_07210	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
F6X00_07215	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
F6X00_07220	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
F6X00_07260	COG1185	polyribonucleotide nucleotidyltransferase activity
F6X00_07275	COG0534	Mate efflux family protein
F6X00_07280	COG0826	peptidase U32
F6X00_07285	COG0826	peptidase U32
F6X00_07295	COG3154	lipid carrier protein
F6X00_07300	COG3153	acetyltransferase
F6X00_07310	COG0456	acetyltransferase
F6X00_07320	COG3706	GGDEF domain
F6X00_07330	COG0084	hydrolase, TatD family'
F6X00_07335	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
F6X00_07340	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
F6X00_07345	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
F6X00_07350	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
F6X00_07355	COG0813	purine-nucleoside phosphorylase activity
F6X00_07365	COG0560	Phosphoserine phosphatase
F6X00_07375	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
F6X00_07380	COG5001	Diguanylate cyclase
F6X00_07380	COG3447	MASE1 domain protein
F6X00_07380	COG5002	protein histidine kinase activity
F6X00_07395	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
F6X00_07400	COG1022	Amp-dependent synthetase and ligase
F6X00_07435	COG4964	Belongs to the GSP D family
F6X00_07485	COG2059	Chromate
F6X00_07490	COG0583	DNA-binding transcription factor activity
F6X00_07500	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
F6X00_07500	COG3408	Glycogen debranching enzyme
F6X00_07505	COG0531	amino acid
F6X00_07510	COG0531	amino acid
F6X00_07515	COG2731	YhcH YjgK YiaL family protein
F6X00_07520	COG3250	beta-galactosidase activity
F6X00_07530	COG1609	Transcriptional regulator
F6X00_07535	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
F6X00_07540	COG1085	galactose-1-phosphate uridylyltransferase
F6X00_07550	COG2017	converts alpha-aldose to the beta-anomer
F6X00_07555	COG0840	transmembrane signaling receptor activity
F6X00_07565	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
F6X00_07580	COG0569	domain protein
F6X00_07580	COG0189	ligase activity
F6X00_07595	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
F6X00_07600	COG1349	DNA-binding transcription factor activity
F6X00_07605	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
F6X00_07610	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
F6X00_07615	COG2171	N-acyltransferase activity
F6X00_07620	COG3141	response to X-ray
F6X00_07635	COG3083	sulfuric ester hydrolase activity
F6X00_07640	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
F6X00_07645	COG1074	ATP-dependent DNA helicase activity
F6X00_07650	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
F6X00_07670	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
F6X00_07675	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
F6X00_07680	COG2166	iron-sulfur cluster assembly
F6X00_07685	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
F6X00_07690	COG0693	protein deglycase activity
F6X00_07695	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
F6X00_07700	COG3248	Nucleoside-binding outer membrane protein
F6X00_07710	COG1595	DNA-templated transcription, initiation
F6X00_07720	COG2211	Major facilitator Superfamily
F6X00_07735	COG2813	Specifically methylates the guanine in position
F6X00_07740	COG0271	Belongs to the BolA IbaG family
F6X00_07745	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
F6X00_07750	COG1805	sodium ion transport
F6X00_07755	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
F6X00_07765	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
F6X00_07770	COG2871	sodium ion transport
F6X00_07775	COG1477	protein flavinylation
F6X00_07795	COG0514	ATP-dependent DNA helicase (RecQ)
F6X00_07810	COG0733	neurotransmitter:sodium symporter activity
F6X00_07835	COG1720	tRNA m6t6A37 methyltransferase activity
F6X00_07840	COG0254	rRNA binding
F6X00_07850	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
F6X00_07885	COG3098	single-species biofilm formation
F6X00_07900	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
F6X00_07905	COG0024	Methionine aminopeptidase
F6X00_07910	COG0052	Belongs to the universal ribosomal protein uS2 family
F6X00_07915	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
F6X00_07920	COG0528	UMP kinase activity
F6X00_07925	COG0233	cytoplasmic translational termination
F6X00_07930	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
F6X00_07935	COG0575	Belongs to the CDS family
F6X00_07940	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
F6X00_07945	COG0750	zinc metalloprotease
F6X00_07950	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
F6X00_07955	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
F6X00_07965	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
F6X00_07970	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
F6X00_07975	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
F6X00_07980	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
F6X00_07985	COG0587	DNA-directed DNA polymerase activity
F6X00_07990	COG0825	malonyl-CoA metabolic process
F6X00_07995	COG0037	tRNA processing
F6X00_08005	COG0347	Belongs to the P(II) protein family
F6X00_08010	COG3021	interspecies interaction between organisms
F6X00_08020	COG1388	LysM domain
F6X00_08020	COG0741	lytic transglycosylase activity
F6X00_08025	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
F6X00_08030	COG2226	methyltransferase
F6X00_08035	COG0328	RNA-DNA hybrid ribonuclease activity
F6X00_08070	COG1960	acyl-CoA dehydrogenase activity
F6X00_08080	COG0121	glutamine amidotransferase
F6X00_08085	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
F6X00_08090	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
F6X00_08095	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
F6X00_08100	COG2233	PERMEase
F6X00_08120	COG1393	Belongs to the ArsC family
F6X00_08125	COG4783	chaperone-mediated protein folding
F6X00_08140	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
F6X00_08145	COG2716	regulation of RNA biosynthetic process
F6X00_08150	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
F6X00_08175	COG1393	Belongs to the ArsC family
F6X00_08200	COG2837	iron assimilation
F6X00_08205	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
F6X00_08210	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
F6X00_08215	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
F6X00_08220	COG1334	flagellar protein FlaG
F6X00_08225	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
F6X00_08235	COG1516	flagellar protein fliS
F6X00_08245	COG4191	Histidine kinase
F6X00_08255	COG1677	Flagellar hook-basal body complex protein FliE
F6X00_08265	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
F6X00_08315	COG1987	bacterial-type flagellum assembly
F6X00_08320	COG1684	flagellar biosynthetic protein fliR
F6X00_08355	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
F6X00_08360	COG0784	Response regulator, receiver
F6X00_08360	COG0643	Histidine kinase
F6X00_08360	COG2198	Histidine kinase
F6X00_08370	COG1192	Involved in chromosome partitioning
F6X00_08380	COG0835	chemotaxis
F6X00_08390	COG4133	protoheme IX ABC transporter activity
F6X00_08395	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
F6X00_08400	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
F6X00_08405	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
F6X00_08410	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
F6X00_08415	COG1138	Cytochrome C-type biogenesis protein
F6X00_08420	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
F6X00_08425	COG3088	subunit of a heme lyase
F6X00_08425	COG4235	cytochrome complex assembly
F6X00_08435	COG2853	Lipoprotein
F6X00_08440	COG2067	long-chain fatty acid transport protein
F6X00_08445	COG2067	long-chain fatty acid transport protein
F6X00_08465	COG1024	Enoyl-CoA hydratase
F6X00_08465	COG1250	3-hydroxyacyl-CoA dehydrogenase
F6X00_08470	COG1025	Belongs to the peptidase M16 family
F6X00_08480	COG2062	phosphohistidine phosphatase, SixA
F6X00_08485	COG2840	Smr protein MutS2
F6X00_08490	COG2890	protein-(glutamine-N5) methyltransferase activity
F6X00_08495	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
F6X00_08500	COG2860	membrane
F6X00_08505	COG3101	peptidyl-lysine hydroxylation
F6X00_08520	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
F6X00_08530	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
F6X00_08540	COG0101	tRNA pseudouridine synthase activity
F6X00_08545	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
F6X00_08550	COG0285	dihydrofolate synthase activity
F6X00_08555	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
F6X00_08560	COG1286	toxin biosynthetic process
F6X00_08565	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
F6X00_08570	COG0583	DNA-binding transcription factor activity
F6X00_08575	COG0745	RESPONSE REGULATOR receiver
F6X00_08585	COG2832	Protein of unknown function (DUF454)
F6X00_08590	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
F6X00_08600	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
F6X00_08605	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
F6X00_08620	COG2205	protein histidine kinase activity
F6X00_08625	COG0745	RESPONSE REGULATOR receiver
F6X00_08640	COG2983	Belongs to the UPF0260 family
F6X00_08650	COG0346	lactoylglutathione lyase activity
F6X00_08660	COG1785	Belongs to the alkaline phosphatase family
F6X00_08675	COG2226	methyltransferase
F6X00_08680	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
F6X00_08690	COG2239	Acts as a magnesium transporter
F6X00_08695	COG2203	Gaf domain
F6X00_08695	COG2199	diguanylate cyclase activity
F6X00_08710	COG3710	Transcriptional regulator
F6X00_08715	COG0531	amino acid
F6X00_08720	COG1982	Orn Lys Arg decarboxylase major
F6X00_08725	COG3706	GGDEF domain
F6X00_08730	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
F6X00_08730	COG0517	IMP dehydrogenase activity
F6X00_08730	COG0617	tRNA 3'-terminal CCA addition
F6X00_08755	COG0537	adenosine 5'-monophosphoramidase activity
F6X00_08785	COG1252	NADH dehydrogenase
F6X00_08800	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
F6X00_08810	COG4591	ABC-type transport system involved in lipoprotein release permease component
F6X00_08815	COG1136	(ABC) transporter
F6X00_08820	COG4591	ABC-type transport system involved in lipoprotein release permease component
F6X00_08830	COG0658	competence protein
F6X00_08830	COG2333	competence protein COMEC
F6X00_08840	COG1663	tetraacyldisaccharide 4'-kinase activity
F6X00_08845	COG2835	tetraacyldisaccharide 4'-kinase activity
F6X00_08850	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
F6X00_08855	COG2199	diguanylate cyclase activity
F6X00_08860	COG2719	SpoVR family
F6X00_08865	COG2718	Belongs to the UPF0229 family
F6X00_08870	COG2766	serine protein kinase
F6X00_08875	COG3713	MltA-interacting MipA family protein
F6X00_08880	COG3013	Belongs to the UPF0304 family
F6X00_08890	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
F6X00_08905	COG1882	Formate acetyltransferase
F6X00_08945	COG0708	Exodeoxyribonuclease III
F6X00_09065	COG4695	Portal protein
F6X00_09190	COG0840	transmembrane signaling receptor activity
F6X00_09200	COG3923	Primosomal replication protein n
F6X00_09210	COG1199	ATP-dependent helicase activity
F6X00_09215	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
F6X00_09235	COG1278	Cold shock
F6X00_09240	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
F6X00_09245	COG0542	response to heat
F6X00_09250	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
F6X00_09270	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
F6X00_09280	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
F6X00_09290	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
F6X00_09315	COG3070	regulator of competence-specific genes
F6X00_09320	COG1609	Transcriptional regulator
F6X00_09325	COG3381	protein complex oligomerization
F6X00_09330	COG0745	RESPONSE REGULATOR receiver
F6X00_09335	COG1434	Gram-negative-bacterium-type cell wall biogenesis
F6X00_09340	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
F6X00_09345	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
F6X00_09350	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
F6X00_09355	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
F6X00_09385	COG4067	protein conserved in archaea
F6X00_09385	COG0189	ligase activity
F6X00_09390	COG0500	methyltransferase
F6X00_09395	COG4106	trans-aconitate 2-methyltransferase activity
F6X00_09405	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
F6X00_09415	COG0840	transmembrane signaling receptor activity
F6X00_09420	COG0632	four-way junction helicase activity
F6X00_09425	COG2255	four-way junction helicase activity
F6X00_09430	COG1271	oxidase subunit
F6X00_09435	COG1294	oxidase, subunit
F6X00_09440	COG4890	Cyd operon protein YbgT
F6X00_09450	COG0824	Thioesterase
F6X00_09455	COG0811	peptide transport
F6X00_09470	COG0823	Involved in the tonB-independent uptake of proteins
F6X00_09475	COG2885	chlorophyll binding
F6X00_09480	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
F6X00_09495	COG3766	membrane
F6X00_09505	COG0754	glutathionylspermidine amidase activity
F6X00_09515	COG2205	protein histidine kinase activity
F6X00_09515	COG0784	Response regulator, receiver
F6X00_09570	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
F6X00_09585	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
F6X00_09590	COG0840	transmembrane signaling receptor activity
F6X00_09595	COG1349	DNA-binding transcription factor activity
F6X00_09600	COG0738	Major facilitator superfamily
F6X00_09605	COG2407	Converts the aldose L-fucose into the corresponding ketose L-fuculose
F6X00_09610	COG1070	Carbohydrate kinase
F6X00_09615	COG4154	Belongs to the RbsD FucU family
F6X00_09620	COG0235	Class ii aldolase
F6X00_09625	COG1454	alcohol dehydrogenase
F6X00_09630	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
F6X00_09635	COG0861	Integral membrane protein TerC family
F6X00_09655	COG2207	Transcriptional regulator
F6X00_09675	COG1032	radical SAM domain protein
F6X00_09700	COG0583	DNA-binding transcription factor activity
F6X00_09710	COG0857	belongs to the CobB CobQ family
F6X00_09710	COG0280	phosphate acetyltransferase
F6X00_09715	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
F6X00_09720	COG3092	negative regulation of chromosome organization
F6X00_09730	COG4120	Belongs to the binding-protein-dependent transport system permease family
F6X00_09740	COG0366	Alpha amylase catalytic
F6X00_09745	COG2199	diguanylate cyclase activity
F6X00_09755	COG3012	SEC-C Motif Domain Protein
F6X00_09755	COG3318	Belongs to the UPF0149 family
F6X00_09765	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
F6X00_09770	COG2186	Transcriptional regulator
F6X00_09800	COG2989	Protein conserved in bacteria
F6X00_09805	COG3108	Peptidase M15
F6X00_09810	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
F6X00_09825	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
F6X00_09850	COG1846	Transcriptional regulator
F6X00_09855	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
F6X00_09860	COG0840	transmembrane signaling receptor activity
F6X00_09880	COG1448	Aminotransferase
F6X00_09885	COG2770	Histidine kinase
F6X00_09885	COG3437	response regulator, receiver
F6X00_09900	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
F6X00_09910	COG0017	Asparaginyl-tRNA synthetase
F6X00_09915	COG0840	transmembrane signaling receptor activity
F6X00_09920	COG0720	synthase
F6X00_09930	COG2200	EAL domain
F6X00_09935	COG1760	l-serine dehydratase
F6X00_09940	COG0814	amino acid
F6X00_09945	COG0494	nUDIX hydrolase
F6X00_09955	COG0784	Response regulator, receiver
F6X00_09955	COG2205	protein histidine kinase activity
F6X00_09965	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
F6X00_09980	COG3106	COG3106 Predicted ATPase
F6X00_09985	COG3768	UPF0283 membrane protein
F6X00_09990	COG3283	Transcriptional regulator of aromatic amino acids metabolism
F6X00_09995	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
F6X00_10010	COG0471	metal ion transport
F6X00_10015	COG4191	Histidine kinase
F6X00_10015	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F6X00_10025	COG3706	GGDEF domain
F6X00_10030	COG2200	EAL domain
F6X00_10030	COG2199	diguanylate cyclase activity
F6X00_10045	COG3300	MHYT domain
F6X00_10045	COG5001	Diguanylate cyclase
F6X00_10050	COG1328	CTP reductase activity
F6X00_10055	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
F6X00_10060	COG0583	DNA-binding transcription factor activity
F6X00_10075	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
F6X00_10080	COG4667	esterase of the alpha-beta hydrolase superfamily
F6X00_10090	COG1597	lipid kinase activity
F6X00_10095	COG0814	amino acid
F6X00_10110	COG0783	Belongs to the Dps family
F6X00_10125	COG1132	(ABC) transporter
F6X00_10130	COG1132	(ABC) transporter
F6X00_10135	COG1115	amino acid carrier protein
F6X00_10150	COG1596	polysaccharide export
F6X00_10175	COG0438	transferase activity, transferring glycosyl groups
F6X00_10180	COG0297	glycogen (starch) synthase activity
F6X00_10180	COG0438	transferase activity, transferring glycosyl groups
F6X00_10220	COG0443	Heat shock 70 kDa protein
F6X00_10225	COG0443	Heat shock 70 kDa protein
F6X00_10235	COG3706	GGDEF domain
F6X00_10255	COG3713	MltA-interacting MipA family protein
F6X00_10285	COG4964	Belongs to the GSP D family
F6X00_10295	COG2894	cell division
F6X00_10335	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
F6X00_10345	COG1643	Atp-dependent helicase
F6X00_10370	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
F6X00_10380	COG2814	Major facilitator Superfamily
F6X00_10395	COG0840	transmembrane signaling receptor activity
F6X00_10400	COG0010	Belongs to the arginase family
F6X00_10405	COG1166	arginine decarboxylase activity
F6X00_10470	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
F6X00_10475	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
F6X00_10475	COG0072	phenylalanine-tRNA ligase activity
F6X00_10495	COG0776	regulation of translation
F6X00_10505	COG0500	methyltransferase
F6X00_10510	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
F6X00_10515	COG0295	cytidine deaminase activity
F6X00_10530	COG2885	chlorophyll binding
F6X00_10545	COG0247	lactate metabolic process
F6X00_10545	COG0277	FAD linked oxidase domain protein
F6X00_10550	COG2020	methyltransferase activity
F6X00_10565	COG2986	histidine ammonia-lyase
F6X00_10575	COG0010	Belongs to the arginase family
F6X00_10580	COG1228	amidohydrolase
F6X00_10590	COG4326	sporulation control protein
F6X00_10610	COG0291	Belongs to the bacterial ribosomal protein bL35 family
F6X00_10745	COG4628	conserved protein (DUF2132)
F6X00_10960	COG0625	glutathione transferase activity
F6X00_11050	COG0384	phenazine biosynthesis protein PhzF
F6X00_11100	COG0384	phenazine biosynthesis protein PhzF
F6X00_11160	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
F6X00_11210	COG0454	-acetyltransferase
F6X00_11225	COG2026	Addiction module toxin, RelE StbE family
F6X00_11470	COG2026	Addiction module toxin, RelE StbE family
F6X00_11680	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
F6X00_11685	COG2944	sequence-specific DNA binding
F6X00_11755	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
F6X00_11835	COG1028	Short-chain dehydrogenase reductase Sdr
F6X00_11850	COG2161	toxin-antitoxin pair type II binding
F6X00_11855	COG4115	mRNA cleavage
F6X00_11865	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
F6X00_11870	COG2944	sequence-specific DNA binding
F6X00_11930	COG0456	acetyltransferase
F6X00_11930	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
F6X00_11940	COG0625	glutathione transferase activity
F6X00_12060	COG1942	4-Oxalocrotonate Tautomerase
F6X00_12095	COG0582	viral genome integration into host DNA
F6X00_12420	COG0346	lactoylglutathione lyase activity
F6X00_12575	COG0346	lactoylglutathione lyase activity
F6X00_12590	COG0251	oxidation-reduction process
F6X00_12665	COG0534	Mate efflux family protein
F6X00_12670	COG0307	riboflavin synthase, alpha
F6X00_12690	COG3706	GGDEF domain
F6X00_12700	COG0791	NLP P60 protein
F6X00_12705	COG0840	transmembrane signaling receptor activity
F6X00_12720	COG1940	carbohydrate kinase activity
F6X00_12735	COG0746	molybdenum cofactor guanylyltransferase activity
F6X00_12740	COG3842	ATPase activity
F6X00_12745	COG4662	Binding-protein-dependent transport system inner membrane component
F6X00_12755	COG2204	response regulator
F6X00_12760	COG3852	Histidine kinase
F6X00_12775	COG0488	(ABC) transporter
F6X00_12785	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
F6X00_12815	COG3383	formate dehydrogenase (NAD+) activity
F6X00_12815	COG0243	molybdopterin cofactor binding
F6X00_12820	COG0437	4 iron, 4 sulfur cluster binding
F6X00_12855	COG0004	ammonium transporteR
F6X00_12860	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
F6X00_12865	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
F6X00_12875	COG1177	transmembrane transport
F6X00_12880	COG1176	ABC-type spermidine putrescine transport system, permease component I
F6X00_12885	COG3842	ATPase activity
F6X00_12895	COG2992	FlgJ-related protein
F6X00_12905	COG0037	tRNA processing
F6X00_12910	COG0589	response to stress
F6X00_12915	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
F6X00_12930	COG2217	Heavy metal translocating P-type atpase
F6X00_12940	COG2010	Cytochrome c
F6X00_12955	COG3278	Belongs to the heme-copper respiratory oxidase family
F6X00_12970	COG2205	protein histidine kinase activity
F6X00_12970	COG0784	Response regulator, receiver
F6X00_13020	COG1450	Type ii and iii secretion system protein
F6X00_13045	COG3120	sequence-specific DNA binding
F6X00_13050	COG1067	ATP-dependent peptidase activity
F6X00_13055	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
F6X00_13070	COG0488	(ABC) transporter
F6X00_13080	COG0116	Belongs to the methyltransferase superfamily
F6X00_13080	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
F6X00_13095	COG2902	Dehydrogenase
F6X00_13105	COG0308	aminopeptidase N
F6X00_13120	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
F6X00_13125	COG1956	GAF domain-containing protein
F6X00_13130	COG1132	(ABC) transporter
F6X00_13135	COG2995	paraquat-inducible protein a
F6X00_13140	COG3008	intermembrane lipid transfer
F6X00_13145	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
F6X00_13145	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
F6X00_13150	COG2996	Protein conserved in bacteria
F6X00_13165	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
F6X00_13175	COG3706	GGDEF domain
F6X00_13180	COG1793	dna ligase
F6X00_13185	COG1366	Belongs to the anti-sigma-factor antagonist family
F6X00_13215	COG2204	response regulator
F6X00_13260	COG0438	transferase activity, transferring glycosyl groups
F6X00_13270	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
F6X00_13310	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
F6X00_13315	COG0363	glucosamine-6-phosphate deaminase activity
F6X00_13320	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
F6X00_13325	COG4565	transcriptional regulatory protein
F6X00_13330	COG3290	protein histidine kinase activity
F6X00_13345	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F6X00_13370	COG1115	amino acid carrier protein
F6X00_13385	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
F6X00_13390	COG0204	Acyl-transferase
F6X00_13395	COG0348	domain, Protein
F6X00_13400	COG0437	4 iron, 4 sulfur cluster binding
F6X00_13410	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F6X00_13415	COG4597	amino acid ABC transporter
F6X00_13420	COG0765	amino acid transport
F6X00_13425	COG1126	abc transporter atp-binding protein
F6X00_13430	COG0670	Belongs to the BI1 family
F6X00_13440	COG2920	part of a sulfur-relay system
F6X00_13455	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
F6X00_13480	COG3706	GGDEF domain
F6X00_13485	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
F6X00_13490	COG0602	queuosine metabolic process
F6X00_13495	COG0561	phosphatase activity
F6X00_13530	COG2828	Protein conserved in bacteria
F6X00_13535	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
F6X00_13540	COG0372	Belongs to the citrate synthase family
F6X00_13545	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
F6X00_13555	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
F6X00_13595	COG2197	response regulator
F6X00_13605	COG0730	response to heat
F6X00_13620	COG1653	transport
F6X00_13625	COG1175	transmembrane transport
F6X00_13630	COG0395	ABC-type sugar transport system, permease component
F6X00_13640	COG1349	DNA-binding transcription factor activity
F6X00_13645	COG0584	glycerophosphoryl diester phosphodiesterase
F6X00_13660	COG1278	Cold shock
F6X00_13700	COG0625	glutathione transferase activity
F6X00_13710	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
F6X00_13720	COG2195	Cleaves the N-terminal amino acid of tripeptides
F6X00_13725	COG0737	Belongs to the 5'-nucleotidase family
F6X00_13735	COG3063	Type IV pilus biogenesis stability protein PilW
F6X00_13750	COG1451	nucleotide metabolic process
F6X00_13760	COG0583	DNA-binding transcription factor activity
F6X00_13780	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
F6X00_13790	COG2988	succinylglutamate desuccinylase activity
F6X00_13810	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
F6X00_13830	COG2925	Exonuclease
F6X00_13835	COG1380	Effector of murein hydrolase LrgA
F6X00_13840	COG1346	cytolysis
F6X00_13850	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
F6X00_13865	COG1643	Atp-dependent helicase
F6X00_13870	COG0281	malic enzyme
F6X00_13875	COG2949	membrane
F6X00_13880	COG0471	metal ion transport
F6X00_13905	COG0492	ferredoxin-NADP+ reductase activity
F6X00_13910	COG4988	ABC transporter
F6X00_13915	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
F6X00_13920	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
F6X00_13930	COG5002	protein histidine kinase activity
F6X00_13930	COG5002	protein histidine kinase activity
F6X00_13945	COG3070	regulator of competence-specific genes
F6X00_13955	COG2431	L-lysine efflux transmembrane transporter activity
F6X00_13965	COG0076	glutamate decarboxylase activity
F6X00_13970	COG1737	Transcriptional regulator
F6X00_13975	COG1979	alcohol dehydrogenase
F6X00_13980	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
F6X00_13985	COG3273	potassium ion transport
F6X00_13985	COG2985	domain, Protein
F6X00_13990	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
F6X00_14005	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
F6X00_14020	COG1136	(ABC) transporter
F6X00_14025	COG0702	epimerase
F6X00_14040	COG2814	Major facilitator Superfamily
F6X00_14050	COG1061	Type III restriction enzyme res subunit
F6X00_14065	COG2205	protein histidine kinase activity
F6X00_14070	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
F6X00_14105	COG3313	Fe-S protein
F6X00_14115	COG4134	Bacterial extracellular solute-binding protein
F6X00_14120	COG4135	transport system, permease component
F6X00_14125	COG4136	ATPase activity
F6X00_14130	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
F6X00_14135	COG3604	Transcriptional regulator
F6X00_14140	COG1151	hydroxylamine reductase activity
F6X00_14145	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
F6X00_14155	COG0564	pseudouridine synthase activity
F6X00_14165	COG0733	neurotransmitter:sodium symporter activity
F6X00_14175	COG0626	cystathionine gamma-synthase activity
F6X00_14180	COG2818	Glycosylase
F6X00_14200	COG1983	PspC domain protein
F6X00_14210	COG1842	Phage shock protein A
F6X00_14215	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
F6X00_14240	COG4172	Belongs to the ABC transporter superfamily
F6X00_14255	COG1227	inorganic diphosphatase activity
F6X00_14285	COG0243	molybdopterin cofactor binding
F6X00_14290	COG3005	denitrification pathway
F6X00_14295	COG4459	periplasmic nitrate reductase
F6X00_14300	COG0390	transport system, permease component
F6X00_14305	COG2116	formate transmembrane transporter activity
F6X00_14325	COG0583	DNA-binding transcription factor activity
F6X00_14330	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
F6X00_14340	COG1435	thymidine kinase activity
F6X00_14350	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
F6X00_14355	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
F6X00_14360	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
F6X00_14365	COG3012	SEC-C Motif Domain Protein
F6X00_14370	COG0140	phosphoribosyl-ATP diphosphatase activity
F6X00_14370	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
F6X00_14375	COG0107	imidazoleglycerol-phosphate synthase activity
F6X00_14385	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
F6X00_14390	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
F6X00_14390	COG0131	Imidazoleglycerol-phosphate dehydratase
F6X00_14395	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
F6X00_14405	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
F6X00_14410	COG1757	Na H antiporter
F6X00_14415	COG2916	Histone family protein nucleoid-structuring protein H-NS
F6X00_14420	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
F6X00_14435	COG2915	High frequency lysogenization protein hflD homolog
F6X00_14440	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
F6X00_14460	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
F6X00_14475	COG0300	oxidoreductase activity
F6X00_14485	COG0501	Belongs to the peptidase M48B family
F6X00_14490	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
F6X00_14505	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
F6X00_14520	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
F6X00_14525	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
F6X00_14540	COG0686	Belongs to the AlaDH PNT family
F6X00_14550	COG0583	DNA-binding transcription factor activity
F6X00_14595	COG4608	Belongs to the ABC transporter superfamily
F6X00_14600	COG0444	Belongs to the ABC transporter superfamily
F6X00_14605	COG4166	transmembrane transport
F6X00_14610	COG4239	(ABC) transporter, permease
F6X00_14615	COG4174	ABC transporter (Permease)
F6X00_14620	COG0284	orotidine-5'-phosphate decarboxylase activity
F6X00_14625	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
F6X00_14630	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
F6X00_14640	COG0539	negative regulation of cytoplasmic translation
F6X00_14650	COG0616	signal peptide processing
F6X00_14655	COG1028	Short-chain dehydrogenase reductase Sdr
F6X00_14670	COG0587	DNA-directed DNA polymerase activity
F6X00_14675	COG0835	chemotaxis
F6X00_14675	COG0784	Response regulator, receiver
F6X00_14680	COG1940	carbohydrate kinase activity
F6X00_14685	COG0469	pyruvate kinase activity
F6X00_14690	COG4667	esterase of the alpha-beta hydrolase superfamily
F6X00_14705	COG0733	neurotransmitter:sodium symporter activity
F6X00_14720	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
F6X00_14720	COG1263	PTS System
F6X00_14725	COG0084	hydrolase, TatD family'
F6X00_14735	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
F6X00_14740	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
F6X00_14755	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
F6X00_14770	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
F6X00_14775	COG0416	fatty acid biosynthetic process
F6X00_14780	COG0333	Belongs to the bacterial ribosomal protein bL32 family
F6X00_14785	COG1399	metal-binding, possibly nucleic acid-binding protein
F6X00_14790	COG0424	maF-like protein
F6X00_14800	COG1530	ribonuclease E activity
F6X00_14805	COG0659	secondary active sulfate transmembrane transporter activity
F6X00_14810	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
F6X00_14815	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
F6X00_14825	COG0572	uridine kinase
F6X00_14830	COG0489	protein tyrosine kinase activity
F6X00_14835	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
F6X00_14835	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
F6X00_14845	COG3088	subunit of a heme lyase
F6X00_14845	COG4235	cytochrome complex assembly
F6X00_14850	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
F6X00_14855	COG1138	Cytochrome C-type biogenesis protein
F6X00_14860	COG3301	Polysulphide reductase, NrfD
F6X00_14865	COG0437	4 iron, 4 sulfur cluster binding
F6X00_14870	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
F6X00_14875	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
F6X00_14895	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
F6X00_14900	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
F6X00_14905	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
F6X00_14970	COG0322	excinuclease ABC activity
F6X00_14975	COG2197	response regulator
F6X00_14980	COG0417	DNA replication proofreading
F6X00_14985	COG5001	Diguanylate cyclase
F6X00_14995	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
F6X00_15015	COG0009	L-threonylcarbamoyladenylate synthase
F6X00_15020	COG0613	PHP domain protein
F6X00_15030	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
F6X00_15035	COG0512	Glutamine amidotransferase of anthranilate synthase
F6X00_15045	COG0134	indole-3-glycerol-phosphate synthase activity
F6X00_15045	COG0135	phosphoribosylanthranilate isomerase activity
F6X00_15050	COG0133	tryptophan synthase activity
F6X00_15060	COG1301	dicarboxylic acid transport
F6X00_15080	COG2350	Protein conserved in bacteria
F6X00_15090	COG0435	Glutathione S-transferase
F6X00_15100	COG0444	Belongs to the ABC transporter superfamily
F6X00_15105	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F6X00_15110	COG0601	transmembrane transport
F6X00_15120	COG0314	molybdopterin synthase activity
F6X00_15125	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
F6X00_15135	COG0521	Mo-molybdopterin cofactor biosynthetic process
F6X00_15145	COG0391	Required for morphogenesis under gluconeogenic growth conditions
F6X00_15150	COG2198	Histidine kinase
F6X00_15155	COG2204	response regulator
F6X00_15160	COG0556	nucleotide-excision repair
F6X00_15175	COG4657	Part of a membrane complex involved in electron transport
F6X00_15180	COG2878	Part of a membrane complex involved in electron transport
F6X00_15185	COG4656	Part of a membrane complex involved in electron transport
F6X00_15190	COG4658	electron transport chain
F6X00_15195	COG4659	FMN binding
F6X00_15200	COG4660	Part of a membrane complex involved in electron transport
F6X00_15205	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
F6X00_15210	COG0346	lactoylglutathione lyase activity
F6X00_15220	COG2885	chlorophyll binding
F6X00_15225	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
F6X00_15230	COG2056	Na+-H+ antiporter family
F6X00_15240	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
F6X00_15255	COG1028	Short-chain dehydrogenase reductase Sdr
F6X00_15260	COG1454	alcohol dehydrogenase
F6X00_15260	COG1012	belongs to the aldehyde dehydrogenase family
F6X00_15265	COG2095	MarC family integral membrane protein
F6X00_15270	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
F6X00_15280	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
F6X00_15285	COG1757	Na H antiporter
F6X00_15300	COG3081	Nucleoid-associated protein
F6X00_15310	COG3083	sulfuric ester hydrolase activity
F6X00_15335	COG0569	domain protein
F6X00_15340	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
F6X00_15345	COG2731	YhcH YjgK YiaL family protein
F6X00_15350	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
F6X00_15360	COG2205	protein histidine kinase activity
F6X00_15360	COG0784	Response regulator, receiver
F6X00_15365	COG0123	including yeast histone deacetylase and acetoin utilization protein
F6X00_15370	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
F6X00_15375	COG0778	Nitroreductase
F6X00_15380	COG1902	pentaerythritol trinitrate reductase activity
F6X00_15380	COG0446	pyridine nucleotide-disulphide oxidoreductase
F6X00_15385	COG0616	signal peptide processing
F6X00_15390	COG0252	asparaginase activity
F6X00_15395	COG3139	Protein of unknown function (DUF1315)
F6X00_15410	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
F6X00_15445	COG5001	Diguanylate cyclase
F6X00_15460	COG3126	Type III secretion system lipoprotein chaperone (YscW)
F6X00_15465	COG1946	Acyl-CoA thioesterase
F6X00_15475	COG1522	sequence-specific DNA binding
F6X00_15480	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
F6X00_15515	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
F6X00_15520	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F6X00_15570	COG0318	PFAM AMP-dependent synthetase and ligase
F6X00_15580	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
F6X00_15585	COG0596	Alpha beta hydrolase
F6X00_15595	COG1169	isochorismate synthase
F6X00_15600	COG0436	Aminotransferase
F6X00_15605	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
F6X00_15610	COG0232	Belongs to the dGTPase family. Type 2 subfamily
F6X00_15625	COG1555	photosystem II stabilization
F6X00_15630	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
F6X00_15635	COG0776	regulation of translation
F6X00_15640	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
F6X00_15645	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
F6X00_15660	COG4191	Histidine kinase
F6X00_15665	COG2204	response regulator
F6X00_15675	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
F6X00_15680	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
F6X00_15685	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
F6X00_15690	COG3842	ATPase activity
F6X00_15700	COG1175	transmembrane transport
F6X00_15715	COG0745	RESPONSE REGULATOR receiver
F6X00_15720	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
F6X00_15765	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
F6X00_15770	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
F6X00_15790	COG1216	Glycosyl transferase, family 2
F6X00_15795	COG2986	histidine ammonia-lyase
F6X00_15820	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
F6X00_15830	COG1028	Short-chain dehydrogenase reductase Sdr
F6X00_15845	COG5002	protein histidine kinase activity
F6X00_15850	COG0745	RESPONSE REGULATOR receiver
F6X00_15860	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
F6X00_15870	COG2951	lytic endotransglycosylase activity
F6X00_15880	COG0850	regulation of cytokinetic process
F6X00_15885	COG2894	cell division
F6X00_15890	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
F6X00_15895	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
F6X00_15900	COG0318	PFAM AMP-dependent synthetase and ligase
F6X00_15905	COG0596	Alpha beta hydrolase
F6X00_15920	COG1214	PFAM Peptidase M22, glycoprotease
F6X00_15925	COG1199	ATP-dependent helicase activity
F6X00_15935	COG0788	formyltetrahydrofolate deformylase activity
F6X00_15940	COG3102	Protein conserved in bacteria
F6X00_15965	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
F6X00_15970	COG1918	ferrous iron import across plasma membrane
F6X00_15980	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
F6X00_15985	COG1121	(ABC) transporter
F6X00_15990	COG1108	ABC-type Mn2 Zn2 transport systems permease components
F6X00_16005	COG0508	dehydrogenase complex catalyzes the overall conversion of
F6X00_16010	COG0567	Dehydrogenase, E1 component
F6X00_16020	COG1053	succinate dehydrogenase
F6X00_16025	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
F6X00_16030	COG2009	succinate dehydrogenase
F6X00_16040	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
F6X00_16050	COG0446	pyridine nucleotide-disulphide oxidoreductase
F6X00_16060	COG0251	oxidation-reduction process
F6X00_16065	COG2964	Protein conserved in bacteria
F6X00_16070	COG0033	Phosphoglucomutase
F6X00_16075	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
F6X00_16080	COG0596	Alpha beta hydrolase
F6X00_16090	COG0716	FMN binding
F6X00_16105	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
F6X00_16110	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
F6X00_16110	COG2190	(PTS) system
F6X00_16110	COG1263	PTS System
F6X00_16115	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
F6X00_16120	COG1846	Transcriptional regulator
F6X00_16120	COG1940	carbohydrate kinase activity
F6X00_16125	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
F6X00_16125	COG4651	solute:proton antiporter activity
F6X00_16130	COG0367	asparagine synthase
F6X00_16140	COG3104	oligopeptide transport
F6X00_16145	COG0840	transmembrane signaling receptor activity
F6X00_16150	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
F6X00_16165	COG3710	Transcriptional regulator
F6X00_16185	COG0622	Phosphoesterase
F6X00_16210	COG1090	epimerase
F6X00_16215	COG0300	oxidoreductase activity
F6X00_16225	COG3118	belongs to the thioredoxin family
F6X00_16230	COG0330	HflC and HflK could
F6X00_16250	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
F6X00_16260	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
F6X00_16265	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
F6X00_16270	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
F6X00_16275	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
F6X00_16280	COG2190	(PTS) system
F6X00_16285	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
F6X00_16290	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
F6X00_16295	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
F6X00_16300	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
F6X00_16310	COG3951	Flagellar rod assembly protein muramidase FlgJ
F6X00_16310	COG1705	Flagellar rod assembly protein muramidase FlgJ
F6X00_16315	COG1706	bacterial-type flagellum-dependent cell motility
F6X00_16330	COG4787	bacterial-type flagellum-dependent cell motility
F6X00_16335	COG1749	Flagellar hook protein flgE
F6X00_16350	COG1815	bacterial-type flagellum-dependent cell motility
F6X00_16355	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
F6X00_16360	COG0835	chemotaxis
F6X00_16360	COG0784	Response regulator, receiver
F6X00_16405	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
F6X00_16420	COG2217	Heavy metal translocating P-type atpase
F6X00_16420	COG2608	mercury ion transmembrane transporter activity
F6X00_16435	COG3735	TraB family
F6X00_16450	COG2840	Smr protein MutS2
F6X00_16455	COG1187	pseudouridine synthase activity
F6X00_16470	COG2877	3-deoxy-8-phosphooctulonate synthase activity
F6X00_16475	COG2912	Transglutaminase-like superfamily
F6X00_16485	COG2890	protein-(glutamine-N5) methyltransferase activity
F6X00_16490	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
F6X00_16495	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
F6X00_16505	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
F6X00_16510	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
F6X00_16515	COG0193	aminoacyl-tRNA hydrolase activity
F6X00_16605	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
F6X00_16610	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
F6X00_16615	COG1702	phosphate starvation-inducible protein PhoH
F6X00_16620	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
F6X00_16625	COG4535	Mg2 and Co2 transporter CorC
F6X00_16630	COG0815	Transfers the fatty acyl group on membrane lipoproteins
F6X00_16635	COG2888	peptidyl-tyrosine sulfation
F6X00_16645	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
F6X00_16650	COG1466	dna polymerase III delta subunit
F6X00_16655	COG0799	negative regulation of ribosome biogenesis
F6X00_16660	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
F6X00_16665	COG0768	penicillin binding
F6X00_16670	COG0772	Belongs to the SEDS family
F6X00_16675	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
F6X00_16680	COG1686	Belongs to the peptidase S11 family
F6X00_16685	COG2921	Belongs to the UPF0250 family
F6X00_16690	COG0321	lipoyl(octanoyl) transferase activity
F6X00_16695	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
F6X00_16705	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
F6X00_16735	COG0366	Alpha amylase catalytic
F6X00_16740	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
F6X00_16740	COG1263	PTS System
F6X00_16750	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
F6X00_16755	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
F6X00_16760	COG2011	ABC-type metal ion transport system permease component
F6X00_16765	COG1464	Belongs to the NlpA lipoprotein family
F6X00_16770	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
F6X00_16790	COG3706	GGDEF domain
F6X00_16795	COG1611	Belongs to the LOG family
F6X00_16815	COG2363	Small membrane protein
F6X00_16825	COG0583	DNA-binding transcription factor activity
F6X00_16830	COG0301	tRNA thio-modification
F6X00_16830	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
F6X00_16840	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
F6X00_16845	COG1722	exodeoxyribonuclease VII activity
F6X00_16850	COG0142	geranyltranstransferase activity
F6X00_16855	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
F6X00_16860	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
F6X00_16865	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
F6X00_16870	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
F6X00_16875	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
F6X00_16890	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
F6X00_16890	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
F6X00_16895	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
F6X00_16905	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
F6X00_16920	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
F6X00_16925	COG2252	PERMEase
F6X00_16930	COG2195	Cleaves the N-terminal amino acid of tripeptides
F6X00_16960	COG0668	transmembrane transport
F6X00_16985	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
F6X00_16990	COG0793	Belongs to the peptidase S41A family
F6X00_16990	COG4946	Tricorn protease homolog
F6X00_17010	COG4720	Psort location CytoplasmicMembrane, score
F6X00_17015	COG1566	PFAM secretion protein HlyD family protein
F6X00_17025	COG3706	GGDEF domain
F6X00_17040	COG0813	purine-nucleoside phosphorylase activity
F6X00_17045	COG3272	Protein of unknown function (DUF1722)
F6X00_17050	COG0789	Transcriptional regulator
F6X00_17055	COG0415	Belongs to the DNA photolyase family
F6X00_17060	COG1376	ErfK ybiS ycfS ynhG family protein
F6X00_17060	COG1388	LysM domain
F6X00_17070	COG0513	Belongs to the DEAD box helicase family
F6X00_17115	COG0573	inorganic phosphate transmembrane transporter activity
F6X00_17120	COG0581	inorganic phosphate transmembrane transporter activity
F6X00_17125	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
F6X00_17130	COG4251	negative regulation of phosphorylation
F6X00_17130	COG5001	Diguanylate cyclase
F6X00_17130	COG3706	GGDEF domain
F6X00_17130	COG2203	Gaf domain
F6X00_17140	COG2304	oxidoreductase activity
F6X00_17160	COG0714	Associated with various cellular activities
F6X00_17230	COG1596	polysaccharide export
F6X00_17240	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
F6X00_17245	COG3842	ATPase activity
F6X00_17260	COG1175	transmembrane transport
F6X00_17265	COG3833	ABC-type maltose transport systems, permease component
F6X00_17295	COG2354	Protein conserved in bacteria
F6X00_17305	COG0418	dihydroorotase activity
F6X00_17310	COG0633	Ferredoxin
F6X00_17310	COG3217	Mosc domain protein beta barrel domain protein
F6X00_17310	COG3217	Mosc domain protein beta barrel domain protein
F6X00_17310	COG0633	Ferredoxin
F6X00_17315	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
F6X00_17360	COG3385	transposase activity
F6X00_17370	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F6X00_17380	COG0848	biopolymer transport protein
F6X00_17385	COG0811	peptide transport
F6X00_17390	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
F6X00_17400	COG3721	Heme iron utilization protein
F6X00_17405	COG0748	coenzyme F420 binding
F6X00_17415	COG0835	chemotaxis
F6X00_17415	COG0784	Response regulator, receiver
F6X00_17420	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
F6X00_17425	COG0589	response to stress
F6X00_17430	COG0366	Alpha amylase catalytic
F6X00_17440	COG0840	transmembrane signaling receptor activity
F6X00_17475	COG0739	heme binding
F6X00_17495	COG2084	Dehydrogenase
F6X00_17520	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
F6X00_17540	COG0840	transmembrane signaling receptor activity
F6X00_17555	COG3706	GGDEF domain
F6X00_17560	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
F6X00_17560	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
F6X00_17565	COG1765	OsmC-like protein
F6X00_17595	COG1765	OsmC-like protein
F6X00_17620	COG1011	Hydrolase
F6X00_17645	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
F6X00_17650	COG2207	Transcriptional regulator
F6X00_17650	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
F6X00_17665	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
F6X00_17670	COG1840	ABC-type Fe3 transport system, periplasmic component
F6X00_17675	COG3842	ATPase activity
F6X00_17695	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
F6X00_17700	COG0583	DNA-binding transcription factor activity
F6X00_17710	COG3104	oligopeptide transport
F6X00_17715	COG1760	l-serine dehydratase
F6X00_17735	COG1686	Belongs to the peptidase S11 family
F6X00_17755	COG1309	transcriptional regulator
F6X00_17760	COG1012	belongs to the aldehyde dehydrogenase family
F6X00_17780	COG4175	Glycine betaine
F6X00_17785	COG3059	membrane
F6X00_17800	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
F6X00_17820	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
F6X00_17830	COG0247	lactate metabolic process
F6X00_17835	COG0546	phosphoglycolate phosphatase activity
F6X00_17845	COG1619	proteins homologs of microcin C7 resistance protein MccF
F6X00_17850	COG2133	pyrroloquinoline quinone binding
F6X00_17860	COG1454	alcohol dehydrogenase
F6X00_17865	COG0443	Heat shock 70 kDa protein
F6X00_17870	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
F6X00_17900	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
F6X00_17905	COG3174	membrane
F6X00_17930	COG0814	amino acid
F6X00_17935	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
F6X00_17960	COG2962	Rard protein
F6X00_17975	COG0671	phosphoesterase, PA-phosphatase related
F6X00_17985	COG1288	antiporter activity
F6X00_18000	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
F6X00_18015	COG2425	protein containing a von Willebrand factor type A (vWA) domain
F6X00_18020	COG2315	Protein conserved in bacteria
F6X00_18035	COG1869	D-ribose catabolic process
F6X00_18045	COG1172	Belongs to the binding-protein-dependent transport system permease family
F6X00_18050	COG1879	ABC-type sugar transport system periplasmic component
F6X00_18055	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
F6X00_18060	COG1609	Transcriptional regulator
F6X00_18070	COG0784	Response regulator, receiver
F6X00_18070	COG0835	chemotaxis
F6X00_18080	COG0456	acetyltransferase
F6X00_18095	COG1366	Belongs to the anti-sigma-factor antagonist family
F6X00_18105	COG2172	sigma factor antagonist activity
F6X00_18120	COG3437	response regulator, receiver
F6X00_18125	COG0420	3'-5' exonuclease activity
F6X00_18130	COG0419	ATPase involved in DNA repair
F6X00_18140	COG0583	DNA-binding transcription factor activity
F6X00_18160	COG4964	Belongs to the GSP D family
F6X00_18245	COG0471	metal ion transport
F6X00_18250	COG3290	protein histidine kinase activity
F6X00_18260	COG0110	maltose O-acetyltransferase activity
F6X00_18280	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F6X00_18285	COG4605	iron ion homeostasis
F6X00_18290	COG4604	ABC transporter, ATP-binding protein
F6X00_18295	COG0789	Transcriptional regulator
F6X00_18325	COG1289	transmembrane transporter activity
F6X00_18330	COG0210	DNA helicase
F6X00_18335	COG1803	Methylglyoxal synthase
F6X00_18340	COG1879	ABC-type sugar transport system periplasmic component
F6X00_18365	COG1262	PFAM Formylglycine-generating sulfatase enzyme
F6X00_18370	COG3005	denitrification pathway
F6X00_18395	COG0513	Belongs to the DEAD box helicase family
F6X00_18405	COG5001	Diguanylate cyclase
F6X00_18405	COG1716	ATPase activity
F6X00_18430	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
F6X00_18445	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
F6X00_18450	COG0513	Belongs to the DEAD box helicase family
F6X00_18455	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
F6X00_18490	COG3335	DDE superfamily endonuclease
F6X00_18510	COG3706	GGDEF domain
F6X00_18655	COG0210	DNA helicase
F6X00_18670	COG3550	peptidyl-serine autophosphorylation
F6X00_18675	COG3119	arylsulfatase activity
F6X00_18685	COG3119	arylsulfatase activity
F6X00_18690	COG0641	radical SAM
F6X00_18695	COG0714	Associated with various cellular activities
F6X00_18730	COG1524	type I phosphodiesterase nucleotide pyrophosphatase
F6X00_18740	COG0641	radical SAM
F6X00_18770	COG2814	Major facilitator Superfamily
F6X00_18805	COG0583	DNA-binding transcription factor activity
F6X00_18810	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
F6X00_18825	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
F6X00_18835	COG1132	(ABC) transporter
F6X00_18845	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
F6X00_18845	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
F6X00_18850	COG0509	glycine decarboxylation via glycine cleavage system
F6X00_18855	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
F6X00_18900	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
F6X00_18900	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
F6X00_18900	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
F6X00_18905	COG1105	Belongs to the carbohydrate kinase PfkB family
F6X00_18910	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
F6X00_18910	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
F6X00_18915	COG1609	Transcriptional regulator
F6X00_18940	COG0469	pyruvate kinase activity
F6X00_18945	COG2271	Major facilitator Superfamily
F6X00_18955	COG4191	Histidine kinase
F6X00_18965	COG1979	alcohol dehydrogenase
F6X00_18970	COG2207	Transcriptional regulator
F6X00_18980	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
F6X00_18985	COG2759	Belongs to the formate--tetrahydrofolate ligase family
F6X00_18990	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
F6X00_19010	COG0546	phosphoglycolate phosphatase activity
F6X00_19030	COG0513	Belongs to the DEAD box helicase family
F6X00_19045	COG3038	cytochrome b561
F6X00_19050	COG2353	YceI-like domain
F6X00_19055	COG2116	formate transmembrane transporter activity
F6X00_19060	COG0583	DNA-binding transcription factor activity
F6X00_19070	COG3593	DNA synthesis involved in DNA repair
F6X00_19075	COG0737	Belongs to the 5'-nucleotidase family
F6X00_19080	COG0861	Integral membrane protein TerC family
F6X00_19110	COG2267	carboxylic ester hydrolase activity
F6X00_19115	COG2067	long-chain fatty acid transport protein
F6X00_19130	COG2050	protein possibly involved in aromatic compounds catabolism
F6X00_19140	COG4533	DNA binding
F6X00_19150	COG0366	Alpha amylase catalytic
F6X00_19155	COG0583	DNA-binding transcription factor activity
F6X00_19175	COG0484	heat shock protein binding
F6X00_19190	COG1716	ATPase activity
F6X00_19190	COG5001	Diguanylate cyclase
F6X00_19195	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
F6X00_19205	COG4181	ATPase activity
F6X00_19210	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
F6X00_19215	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
F6X00_19215	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
F6X00_19220	COG1984	allophanate hydrolase subunit 2
F6X00_19225	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
F6X00_19240	COG3447	MASE1 domain protein
F6X00_19240	COG5001	Diguanylate cyclase
F6X00_19240	COG5002	protein histidine kinase activity
F6X00_19250	COG0583	DNA-binding transcription factor activity
F6X00_19255	COG0045	succinate-CoA ligase (ADP-forming) activity
F6X00_19255	COG1042	CoA-binding domain protein
F6X00_19255	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
F6X00_19265	COG1181	Belongs to the D-alanine--D-alanine ligase family
F6X00_19275	COG0023	Translation Initiation Factor
F6X00_19615	COG3140	Belongs to the UPF0181 family
F6X00_19630	COG0745	RESPONSE REGULATOR receiver
F6X00_19640	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
F6X00_19645	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
F6X00_19660	COG3706	GGDEF domain
F6X00_19670	COG0745	RESPONSE REGULATOR receiver
F6X00_19680	COG1846	Transcriptional regulator
F6X00_19685	COG0697	spore germination
F6X00_19695	COG4149	molybdate abc transporter
F6X00_19700	COG0725	ABC transporter, periplasmic molybdate-binding protein
F6X00_19720	COG4067	protein conserved in archaea
F6X00_19720	COG0189	ligase activity
F6X00_19730	COG0840	transmembrane signaling receptor activity
F6X00_19735	COG0602	queuosine metabolic process
F6X00_19740	COG1328	CTP reductase activity
F6X00_19795	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
F6X00_19800	COG3118	belongs to the thioredoxin family
F6X00_19805	COG0477	Major facilitator Superfamily
F6X00_19815	COG0534	Mate efflux family protein
F6X00_19835	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
F6X00_19850	COG0848	biopolymer transport protein
F6X00_19855	COG0811	peptide transport
F6X00_19860	COG0811	peptide transport
F6X00_19895	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
F6X00_19930	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
F6X00_19940	COG3706	GGDEF domain
F6X00_19940	COG4251	negative regulation of phosphorylation
F6X00_19940	COG5001	Diguanylate cyclase
F6X00_19940	COG2203	Gaf domain
F6X00_19950	COG0010	Belongs to the arginase family
F6X00_19955	COG0513	Belongs to the DEAD box helicase family
F6X00_19965	COG0523	cobalamin synthesis protein
F6X00_19975	COG2199	diguanylate cyclase activity
F6X00_19990	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
F6X00_19990	COG2146	nitrite reductase [NAD(P)H] activity
F6X00_19995	COG1116	anion transmembrane transporter activity
F6X00_20000	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
F6X00_20005	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
F6X00_20005	COG1116	anion transmembrane transporter activity
F6X00_20030	COG1648	precorrin-2 dehydrogenase activity
F6X00_20030	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
F6X00_20035	COG0243	molybdopterin cofactor binding
F6X00_20040	COG0456	acetyltransferase
F6X00_20040	COG1214	PFAM Peptidase M22, glycoprotease
F6X00_20045	COG0366	Alpha amylase catalytic
F6X00_20050	COG0840	transmembrane signaling receptor activity
F6X00_20055	COG0840	transmembrane signaling receptor activity
F6X00_20070	COG2271	Major facilitator Superfamily
F6X00_20075	COG0584	glycerophosphoryl diester phosphodiesterase
F6X00_20080	COG0312	modulator of DNA gyrase
F6X00_20085	COG0312	modulator of DNA gyrase
F6X00_20095	COG3069	C4-dicarboxylate transmembrane transporter activity
F6X00_20100	COG1704	LemA family
F6X00_20105	COG0501	Belongs to the peptidase M48B family
F6X00_20115	COG3209	COG3209 Rhs family protein
F6X00_20130	COG3209	COG3209 Rhs family protein
F6X00_20180	COG3501	Rhs element vgr protein
F6X00_20235	COG0631	protein serine/threonine phosphatase activity
F6X00_20270	COG0515	serine threonine protein kinase
F6X00_20270	COG2815	serine threonine protein kinase
F6X00_20290	COG3530	Putative quorum-sensing-regulated virulence factor
F6X00_20310	COG2154	pterin-4-alpha-carbinolamine dehydratase
F6X00_20315	COG3186	Phenylalanine-4-hydroxylase
F6X00_20320	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
F6X00_20345	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
F6X00_20355	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F6X00_20355	COG4191	Histidine kinase
F6X00_20360	COG0784	Response regulator, receiver
F6X00_20360	COG3437	response regulator, receiver
F6X00_20415	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
F6X00_20415	COG3064	Membrane
F6X00_20415	COG1073	alpha beta
F6X00_20420	COG2994	toxin metabolic process
F6X00_20460	COG1028	Short-chain dehydrogenase reductase Sdr
F6X00_20470	COG1024	Enoyl-CoA hydratase
F6X00_20475	COG1024	Enoyl-CoA hydratase
F6X00_20480	COG1960	acyl-CoA dehydrogenase activity
F6X00_20490	COG0183	Belongs to the thiolase family
F6X00_20500	COG1960	acyl-CoA dehydrogenase activity
F6X00_20505	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
F6X00_20510	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
F6X00_20530	COG1278	Cold shock
F6X00_20545	COG1309	transcriptional regulator
F6X00_20550	COG2130	NADP-dependent
F6X00_20570	COG2197	response regulator
F6X00_20575	COG3851	Histidine kinase
F6X00_20580	COG2271	Major facilitator Superfamily
F6X00_20585	COG1482	cell wall glycoprotein biosynthetic process
F6X00_20595	COG2203	Gaf domain
F6X00_20595	COG2199	diguanylate cyclase activity
F6X00_20605	COG3036	rescue of stalled ribosome
F6X00_20610	COG1278	Cold shock
F6X00_20640	COG0545	Peptidyl-prolyl cis-trans isomerase
F6X00_20645	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
F6X00_20650	COG0840	transmembrane signaling receptor activity
F6X00_20670	COG2195	Cleaves the N-terminal amino acid of tripeptides
F6X00_20680	COG4989	oxidoreductase activity
F6X00_20695	COG0038	chloride channel
F6X00_20705	COG1914	H( )-stimulated, divalent metal cation uptake system
F6X00_20710	COG0302	gtp cyclohydrolase
F6X00_20715	COG0303	'Molybdopterin
F6X00_20720	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
F6X00_20730	COG2897	thiosulfate sulfurtransferase activity
F6X00_20750	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
F6X00_20755	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
F6X00_20770	COG0840	transmembrane signaling receptor activity
F6X00_20775	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
F6X00_20780	COG2885	chlorophyll binding
F6X00_20785	COG0109	protoheme IX farnesyltransferase activity
F6X00_20790	COG1612	heme a metabolic process
F6X00_20815	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
F6X00_20820	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
F6X00_20825	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
F6X00_20830	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
F6X00_20840	COG1280	lysine exporter protein (LysE YggA)
F6X00_20865	COG1846	Transcriptional regulator
F6X00_20870	COG1764	response to oxidative stress
F6X00_20880	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
F6X00_20895	COG0697	spore germination
F6X00_20910	COG2814	Major facilitator Superfamily
F6X00_20915	COG0583	DNA-binding transcription factor activity
F6X00_20920	COG4251	negative regulation of phosphorylation
F6X00_20920	COG2203	Gaf domain
F6X00_20920	COG3706	GGDEF domain
F6X00_20920	COG5001	Diguanylate cyclase
F6X00_20925	COG0251	oxidation-reduction process
F6X00_20940	COG4145	pantothenate transmembrane transporter activity
F6X00_20950	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
F6X00_20960	COG1737	Transcriptional regulator
F6X00_20960	COG0837	glucose binding
F6X00_20970	COG1131	(ABC) transporter
F6X00_20975	COG0842	Transport permease protein
F6X00_21005	COG1846	Transcriptional regulator
F6X00_21020	COG0513	Belongs to the DEAD box helicase family
F6X00_21045	COG3568	Endonuclease Exonuclease Phosphatase
F6X00_21060	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
F6X00_21090	COG0516	GMP reductase activity
F6X00_21100	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
F6X00_21100	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
F6X00_21120	COG2197	response regulator
F6X00_21125	COG3850	Histidine kinase
F6X00_21130	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
F6X00_21140	COG0243	molybdopterin cofactor binding
F6X00_21150	COG3005	denitrification pathway
F6X00_21160	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
F6X00_21165	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
F6X00_21170	COG1737	Transcriptional regulator
F6X00_21175	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
F6X00_21180	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
F6X00_21185	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
F6X00_21190	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
F6X00_21195	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
F6X00_21200	COG1940	carbohydrate kinase activity
F6X00_21205	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
F6X00_21225	COG0183	Belongs to the thiolase family
F6X00_21235	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
F6X00_21240	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
F6X00_21290	COG1879	ABC-type sugar transport system periplasmic component
F6X00_21300	COG2827	Endonuclease containing a URI domain
F6X00_21305	COG3132	Protein of unknown function, DUF480
F6X00_21315	COG2926	Belongs to the UPF0265 family
F6X00_21325	COG0534	Mate efflux family protein
F6X00_21330	COG5002	protein histidine kinase activity
F6X00_21330	COG0784	Response regulator, receiver
F6X00_21330	COG2205	protein histidine kinase activity
F6X00_21355	COG0583	DNA-binding transcription factor activity
F6X00_21380	COG1522	sequence-specific DNA binding
F6X00_21390	COG0531	amino acid
F6X00_21395	COG0121	glutamine amidotransferase
F6X00_21410	COG2205	protein histidine kinase activity
F6X00_21415	COG0745	RESPONSE REGULATOR receiver
F6X00_21445	COG2067	long-chain fatty acid transport protein
F6X00_21455	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F6X00_21480	COG2239	Acts as a magnesium transporter
F6X00_21490	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
F6X00_21495	COG0402	S-adenosylhomocysteine deaminase activity
F6X00_21500	COG1067	ATP-dependent peptidase activity
F6X00_21510	COG4172	Belongs to the ABC transporter superfamily
F6X00_21515	COG1505	serine-type exopeptidase activity
F6X00_21520	COG0583	DNA-binding transcription factor activity
F6X00_21525	COG1620	l-lactate permease
F6X00_21535	COG1139	Iron-sulfur cluster binding protein
F6X00_21560	COG2814	Major facilitator Superfamily
F6X00_21600	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
F6X00_21615	COG3015	lipoprotein NlpE involved in copper resistance
F6X00_21620	COG1126	abc transporter atp-binding protein
F6X00_21625	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F6X00_21630	COG4215	(ABC) transporter
F6X00_21635	COG4160	amino acid transport
F6X00_21650	COG5001	Diguanylate cyclase
F6X00_21650	COG5002	protein histidine kinase activity
F6X00_21655	COG2755	lipolytic protein G-D-S-L family
F6X00_21670	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F6X00_21700	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
F6X00_21705	COG1028	Short-chain dehydrogenase reductase Sdr
F6X00_21710	COG1169	isochorismate synthase
F6X00_21715	COG1021	2,3-dihydroxybenzoate-AMP ligase
F6X00_21735	COG1021	2,3-dihydroxybenzoate-AMP ligase
F6X00_21745	COG4607	ABC-type enterochelin transport system periplasmic component
F6X00_21750	COG4774	siderophore transport
F6X00_21750	COG1629	transport
F6X00_21760	COG0189	ligase activity
F6X00_21765	COG4067	protein conserved in archaea
F6X00_21765	COG0189	ligase activity
F6X00_21790	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
F6X00_21805	COG3033	Beta-eliminating lyase
F6X00_21810	COG0814	amino acid
F6X00_21815	COG0488	(ABC) transporter
F6X00_21830	COG1609	Transcriptional regulator
F6X00_21835	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
F6X00_21860	COG1253	flavin adenine dinucleotide binding
F6X00_21870	COG1012	belongs to the aldehyde dehydrogenase family
F6X00_21875	COG3284	Transcriptional regulator
F6X00_21890	COG0625	glutathione transferase activity
F6X00_21900	COG0384	phenazine biosynthesis protein PhzF
F6X00_21905	COG2197	response regulator
F6X00_21910	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
F6X00_21915	COG0673	inositol 2-dehydrogenase activity
F6X00_21940	COG2015	COG2015, Alkyl sulfatase and related hydrolases
F6X00_21950	COG0583	DNA-binding transcription factor activity
F6X00_21955	COG2194	sulfuric ester hydrolase activity
F6X00_21965	COG0798	PFAM Bile acid sodium symporter
F6X00_21970	COG0640	Transcriptional regulator
F6X00_21990	COG0583	DNA-binding transcription factor activity
F6X00_22005	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
F6X00_22010	COG0700	Nucleoside recognition
F6X00_22015	COG3366	ferrous iron transmembrane transporter activity
F6X00_22025	COG0366	Alpha amylase catalytic
F6X00_22030	COG0823	Involved in the tonB-independent uptake of proteins
F6X00_22035	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
F6X00_22065	COG0800	Aldolase
F6X00_22070	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
F6X00_22075	COG0697	spore germination
F6X00_22085	COG0583	DNA-binding transcription factor activity
F6X00_22095	COG1917	Cupin 2, conserved barrel domain protein
F6X00_22105	COG1028	Short-chain dehydrogenase reductase Sdr
F6X00_22150	COG0668	transmembrane transport
F6X00_22185	COG0494	nUDIX hydrolase
F6X00_22190	COG1881	PFAM PEBP family protein
F6X00_22195	COG2207	Transcriptional regulator
F6X00_22200	COG3046	protein related to deoxyribodipyrimidine photolyase
F6X00_22230	COG0454	-acetyltransferase
F6X00_22240	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
F6X00_22265	COG1858	cytochrome C peroxidase
F6X00_22325	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
F6X00_22335	COG0583	DNA-binding transcription factor activity
F6X00_22355	COG0513	Belongs to the DEAD box helicase family
F6X00_22390	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
F6X00_22400	COG1357	PFAM Pentapeptide repeats (8 copies)
F6X00_22420	COG3437	response regulator, receiver
F6X00_22430	COG0579	oxidoreductase
F6X00_22460	COG2015	COG2015, Alkyl sulfatase and related hydrolases
F6X00_22475	COG2205	protein histidine kinase activity
F6X00_22510	COG3706	GGDEF domain
F6X00_22525	COG2176	DNA-directed DNA polymerase activity
F6X00_22530	COG1136	(ABC) transporter
F6X00_22530	COG0577	efflux transmembrane transporter activity
F6X00_22535	COG1136	(ABC) transporter
F6X00_22535	COG0577	efflux transmembrane transporter activity
F6X00_22565	COG1120	ATPase activity
F6X00_22570	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
F6X00_22600	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
F6X00_22605	COG3716	PTS system mannose fructose sorbose family IID component
F6X00_22615	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
F6X00_22620	COG2222	sugar isomerase
F6X00_22630	COG1349	DNA-binding transcription factor activity
F6X00_22640	COG1349	DNA-binding transcription factor activity
F6X00_22645	COG0697	spore germination
F6X00_22650	COG2207	Transcriptional regulator
F6X00_22665	COG2015	COG2015, Alkyl sulfatase and related hydrolases
F6X00_22690	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
F6X00_22695	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
F6X00_22715	COG0840	transmembrane signaling receptor activity
F6X00_22730	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
F6X00_22760	COG2258	MOSC domain
F6X00_22795	COG0513	Belongs to the DEAD box helicase family
F6X00_22805	COG2186	Transcriptional regulator
F6X00_22815	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
F6X00_22825	COG0246	Mannitol dehydrogenase
F6X00_22830	COG1904	glucuronate isomerase
F6X00_22835	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
F6X00_22840	COG0800	Aldolase
F6X00_22855	COG1028	Short-chain dehydrogenase reductase Sdr
F6X00_22860	COG2999	glutathione oxidoreductase activity
F6X00_22865	COG1902	pentaerythritol trinitrate reductase activity
F6X00_22895	COG0561	phosphatase activity
F6X00_22900	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
F6X00_22905	COG3623	hexulose-6-phosphate isomerase
F6X00_22920	COG1132	(ABC) transporter
F6X00_22940	COG5426	von Willebrand factor, type A
F6X00_22950	COG1028	Short-chain dehydrogenase reductase Sdr
F6X00_22960	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
F6X00_22965	COG0659	secondary active sulfate transmembrane transporter activity
F6X00_22990	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F6X00_22995	COG0601	transmembrane transport
F6X00_23000	COG0747	negative chemotaxis
F6X00_23010	COG3119	arylsulfatase activity
F6X00_23015	COG0641	radical SAM
F6X00_23020	COG3119	arylsulfatase activity
F6X00_23025	COG3119	arylsulfatase activity
F6X00_23030	COG5492	domain, Protein
F6X00_23050	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
F6X00_23075	COG0259	pyridoxamine-phosphate oxidase activity
F6X00_23085	COG2204	response regulator
F6X00_23115	COG3069	C4-dicarboxylate transmembrane transporter activity
F6X00_23120	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
F6X00_23135	COG0459	protein refolding
F6X00_23140	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
F6X00_23145	COG0110	maltose O-acetyltransferase activity
F6X00_23160	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
F6X00_23160	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
F6X00_23165	COG1737	Transcriptional regulator
F6X00_23175	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
F6X00_23180	COG1263	PTS System
F6X00_23180	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
F6X00_23190	COG2203	Gaf domain
F6X00_23190	COG2200	EAL domain
F6X00_23190	COG2199	diguanylate cyclase activity
F6X00_23195	COG0406	alpha-ribazole phosphatase activity
F6X00_23210	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
F6X00_23255	COG0840	transmembrane signaling receptor activity
F6X00_23260	COG2201	protein-glutamate methylesterase activity
F6X00_23270	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
F6X00_23275	COG0840	transmembrane signaling receptor activity
F6X00_23280	COG0835	chemotaxis
F6X00_23295	COG0745	RESPONSE REGULATOR receiver
F6X00_23305	COG1444	tRNA N-acetyltransferase activity
F6X00_23330	COG4608	Belongs to the ABC transporter superfamily
F6X00_23335	COG0444	Belongs to the ABC transporter superfamily
F6X00_23345	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
F6X00_23345	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
F6X00_23365	COG0217	transcriptional regulatory protein
F6X00_23375	COG0583	DNA-binding transcription factor activity
F6X00_23385	COG1136	(ABC) transporter
F6X00_23390	COG4591	ABC-type transport system involved in lipoprotein release permease component
F6X00_23405	COG3275	phosphorelay sensor kinase activity
F6X00_23425	COG0786	glutamate:sodium symporter activity
F6X00_23430	COG0786	glutamate:sodium symporter activity
F6X00_23440	COG0363	glucosamine-6-phosphate deaminase activity
F6X00_23455	COG0189	ligase activity
F6X00_23475	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
F6X00_23480	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
F6X00_23485	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
F6X00_23500	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
F6X00_23510	COG1309	transcriptional regulator
F6X00_23530	COG3123	guanosine phosphorylase activity
F6X00_23535	COG1741	Belongs to the pirin family
F6X00_23545	COG5001	Diguanylate cyclase
F6X00_23550	COG3706	GGDEF domain
F6X00_23605	COG1982	Orn Lys Arg decarboxylase major
F6X00_23610	COG0531	amino acid
F6X00_23620	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
F6X00_23625	COG1162	GTPase activity
F6X00_23630	COG2847	Copper chaperone PCu(A)C
F6X00_23635	COG1999	signal sequence binding
F6X00_23650	COG2909	trisaccharide binding
F6X00_23655	COG0058	SHG alpha-glucan phosphorylase activity
F6X00_23660	COG1640	4-alpha-glucanotransferase
F6X00_23665	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
F6X00_23670	COG0840	transmembrane signaling receptor activity
F6X00_23675	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
F6X00_23735	COG1012	belongs to the aldehyde dehydrogenase family
F6X00_23740	COG0625	glutathione transferase activity
F6X00_23745	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
F6X00_23750	COG1283	sodium-dependent phosphate transmembrane transporter activity
F6X00_23755	COG0612	Peptidase, M16
F6X00_23765	COG0583	DNA-binding transcription factor activity
F6X00_23770	COG0583	DNA-binding transcription factor activity
F6X00_23780	COG0387	Pfam Sodium calcium exchanger
F6X00_23785	COG0586	Pfam SNARE associated Golgi protein
F6X00_23795	COG0642	Histidine kinase
F6X00_23825	COG2199	diguanylate cyclase activity
F6X00_23845	COG1609	Transcriptional regulator
F6X00_23860	COG0395	ABC-type sugar transport system, permease component
F6X00_23870	COG3842	ATPase activity
F6X00_23875	COG1609	Transcriptional regulator
F6X00_23885	COG0747	negative chemotaxis
F6X00_23895	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F6X00_23900	COG0444	Belongs to the ABC transporter superfamily
F6X00_23905	COG4608	Belongs to the ABC transporter superfamily
F6X00_23915	COG1609	Transcriptional regulator
F6X00_23930	COG4580	involved in the transport of maltose and maltodextrins
F6X00_23945	COG1472	Belongs to the glycosyl hydrolase 3 family
F6X00_23950	COG0534	Mate efflux family protein
F6X00_23960	COG1566	PFAM secretion protein HlyD family protein
F6X00_23990	COG0564	pseudouridine synthase activity
F6X00_24015	COG1609	Transcriptional regulator
F6X00_24025	COG1129	ABC transporter
F6X00_24050	COG2211	Major facilitator Superfamily
F6X00_24055	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
F6X00_24060	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
F6X00_24065	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
F6X00_24105	COG1482	cell wall glycoprotein biosynthetic process
F6X00_24110	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
F6X00_24110	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
F6X00_24110	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
F6X00_24115	COG2207	Transcriptional regulator
F6X00_24125	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
F6X00_24130	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
F6X00_24155	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
F6X00_24175	COG3383	formate dehydrogenase (NAD+) activity
F6X00_24185	COG1609	Transcriptional regulator
F6X00_24190	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
F6X00_24190	COG1263	PTS System
F6X00_24195	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
F6X00_24200	COG1482	cell wall glycoprotein biosynthetic process
F6X00_24205	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
F6X00_24210	COG0583	DNA-binding transcription factor activity
F6X00_24265	COG0583	DNA-binding transcription factor activity
F6X00_24270	COG1733	regulation of RNA biosynthetic process
F6X00_24290	COG0137	argininosuccinate synthase activity
F6X00_24300	COG1301	dicarboxylic acid transport
F6X00_24345	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
F6X00_24350	COG2175	clavaminate synthase activity
F6X00_24380	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
F6X00_24390	COG3706	GGDEF domain
F6X00_24405	COG2356	endonuclease I
F6X00_24420	COG1368	sulfuric ester hydrolase activity
F6X00_24425	COG2194	sulfuric ester hydrolase activity
F6X00_24430	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
F6X00_24435	COG2205	protein histidine kinase activity
F6X00_24440	COG0745	RESPONSE REGULATOR receiver
F6X00_24460	COG4221	oxidoreductase activity
F6X00_24485	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
F6X00_24490	COG0076	glutamate decarboxylase activity
F6X00_24495	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
F6X00_24505	COG0561	phosphatase activity
F6X00_24520	COG0671	phosphoesterase, PA-phosphatase related
F6X00_24525	COG0351	phosphomethylpyrimidine kinase
F6X00_24595	COG2814	Major facilitator Superfamily
F6X00_24610	COG0039	L-malate dehydrogenase activity
F6X00_24615	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
F6X00_24620	COG4771	TonB-dependent receptor
F6X00_24640	COG0393	Putative heavy-metal-binding
F6X00_24655	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
F6X00_24665	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
F6X00_24685	COG0753	catalase activity
F6X00_24705	COG0346	lactoylglutathione lyase activity
F6X00_24715	COG2211	Major facilitator Superfamily
F6X00_24730	COG3240	lipase activity
F6X00_24775	COG3646	Phage regulatory protein
F6X00_24780	COG0582	viral genome integration into host DNA
F6X00_24840	COG1802	Transcriptional regulator
F6X00_24840	COG4626	Terminase
F6X00_24865	COG1403	HNH endonuclease
F6X00_24910	COG3772	lysozyme
F6X00_24940	COG1030	water channel activity
F6X00_25025	COG1063	alcohol dehydrogenase
F6X00_25100	COG3040	lipid binding
F6X00_25135	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
F6X00_25145	COG2197	response regulator
F6X00_25165	COG2205	protein histidine kinase activity
F6X00_25165	COG0784	Response regulator, receiver
F6X00_25170	COG3111	PFAM Bacterial OB fold (BOF) protein
F6X00_25180	COG2274	protein secretion by the type I secretion system
F6X00_25310	COG1192	Involved in chromosome partitioning
F6X00_25375	COG1192	Involved in chromosome partitioning
F6X00_25415	COG3692	DNA binding
F6X00_25510	COG3657	addiction module killer protein
F6X00_25515	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD