pp2_256 e2599c57aa0976b5f28962866aa09844 374 Pfam PF13353 4Fe-4S single cluster domain 101 199 3.4E-5 T 30-10-2018 pp2_256 e2599c57aa0976b5f28962866aa09844 374 Gene3D G3DSA:3.20.20.70 90 340 2.3E-21 T 30-10-2018 IPR013785 Aldolase-type TIM barrel GO:0003824 pp2_256 e2599c57aa0976b5f28962866aa09844 374 SUPERFAMILY SSF102114 94 286 3.27E-22 T 30-10-2018 pp2_256 e2599c57aa0976b5f28962866aa09844 374 Pfam PF04055 Radical SAM superfamily 100 259 1.7E-7 T 30-10-2018 IPR007197 Radical SAM GO:0003824|GO:0051536 pp2_256 e2599c57aa0976b5f28962866aa09844 374 Gene3D G3DSA:3.20.20.70 1 76 3.6E-5 T 30-10-2018 IPR013785 Aldolase-type TIM barrel GO:0003824 pp2_043 552176422b9a897e9b6a734825acf0dd 597 PRINTS PR00418 DNA topoisomerase II family signature 405 419 1.8E-31 T 30-10-2018 pp2_043 552176422b9a897e9b6a734825acf0dd 597 PRINTS PR00418 DNA topoisomerase II family signature 546 562 1.8E-31 T 30-10-2018 pp2_043 552176422b9a897e9b6a734825acf0dd 597 PRINTS PR00418 DNA topoisomerase II family signature 263 276 1.8E-31 T 30-10-2018 pp2_043 552176422b9a897e9b6a734825acf0dd 597 PRINTS PR00418 DNA topoisomerase II family signature 48 63 1.8E-31 T 30-10-2018 pp2_043 552176422b9a897e9b6a734825acf0dd 597 PRINTS PR00418 DNA topoisomerase II family signature 85 98 1.8E-31 T 30-10-2018 pp2_043 552176422b9a897e9b6a734825acf0dd 597 PRINTS PR00418 DNA topoisomerase II family signature 129 143 1.8E-31 T 30-10-2018 pp2_043 552176422b9a897e9b6a734825acf0dd 597 PRINTS PR00418 DNA topoisomerase II family signature 470 486 1.8E-31 T 30-10-2018 pp2_043 552176422b9a897e9b6a734825acf0dd 597 SUPERFAMILY SSF56719 390 597 9.68E-45 T 30-10-2018 IPR013760 DNA topoisomerase, type IIA-like domain superfamily GO:0003918|GO:0005524 Reactome: R-HSA-4615885 pp2_043 552176422b9a897e9b6a734825acf0dd 597 Gene3D G3DSA:3.40.50.670 384 597 1.4E-45 T 30-10-2018 IPR013759 DNA topoisomerase, type IIA, subunit B, C-terminal GO:0003677|GO:0003918|GO:0005524|GO:0006265 Reactome: R-HSA-4615885 pp2_043 552176422b9a897e9b6a734825acf0dd 597 SMART SM00433 48 597 3.3E-31 T 30-10-2018 IPR001241 DNA topoisomerase, type IIA GO:0003677|GO:0003918|GO:0005524|GO:0006265 Reactome: R-HSA-4615885 pp2_043 552176422b9a897e9b6a734825acf0dd 597 SUPERFAMILY SSF54211 232 383 1.86E-25 T 30-10-2018 IPR020568 Ribosomal protein S5 domain 2-type fold pp2_043 552176422b9a897e9b6a734825acf0dd 597 Pfam PF00204 DNA gyrase B 249 383 1.3E-18 T 30-10-2018 IPR013506 DNA topoisomerase, type IIA, subunit B, domain 2 GO:0003677|GO:0003918|GO:0005524|GO:0006265 Reactome: R-HSA-4615885 pp2_043 552176422b9a897e9b6a734825acf0dd 597 SUPERFAMILY SSF55874 5 226 5.89E-40 T 30-10-2018 IPR036890 Histidine kinase/HSP90-like ATPase superfamily pp2_043 552176422b9a897e9b6a734825acf0dd 597 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 47 188 1.0E-10 T 30-10-2018 IPR003594 Histidine kinase/HSP90-like ATPase pp2_043 552176422b9a897e9b6a734825acf0dd 597 Gene3D G3DSA:3.30.565.10 10 241 5.3E-52 T 30-10-2018 IPR036890 Histidine kinase/HSP90-like ATPase superfamily pp2_043 552176422b9a897e9b6a734825acf0dd 597 Pfam PF16898 C-terminal associated domain of TOPRIM 515 597 2.0E-9 T 30-10-2018 IPR031660 C-terminal associated domain of TOPRIM Reactome: R-HSA-4615885 pp2_043 552176422b9a897e9b6a734825acf0dd 597 Gene3D G3DSA:3.30.230.10 246 368 1.7E-22 T 30-10-2018 IPR014721 Ribosomal protein S5 domain 2-type fold, subgroup pp2_043 552176422b9a897e9b6a734825acf0dd 597 SMART SM00387 48 190 5.3E-4 T 30-10-2018 IPR003594 Histidine kinase/HSP90-like ATPase pp2_346 3588875f757e0d29c8c9e1596aa7e0b5 228 Gene3D G3DSA:2.20.20.20 76 226 7.2E-10 T 30-10-2018 pp2_346 3588875f757e0d29c8c9e1596aa7e0b5 228 Gene3D G3DSA:3.90.1160.10 90 203 7.2E-10 T 30-10-2018 IPR015976 Bacteriophage T4, Gp11, C-terminal pp2_346 3588875f757e0d29c8c9e1596aa7e0b5 228 Pfam PF08677 GP11 baseplate wedge protein 2 228 8.7E-136 T 30-10-2018 IPR014791 Baseplate structural protein Gp11 pp2_346 3588875f757e0d29c8c9e1596aa7e0b5 228 SUPERFAMILY SSF56558 16 228 4.45E-53 T 30-10-2018 IPR036214 Baseplate structural protein Gp11 superfamily pp2_031 cd31ee6a5b9de6e12f33f9cd48a461c7 299 Gene3D G3DSA:3.30.572.10 1 299 1.5E-90 T 30-10-2018 IPR036926 Thymidylate synthase/dCMP hydroxymethylase superfamily KEGG: 00240+2.1.1.45|KEGG: 00670+2.1.1.45|MetaCyc: PWY-3841|MetaCyc: PWY-7184|MetaCyc: PWY-7187|MetaCyc: PWY-7198|MetaCyc: PWY-7199|MetaCyc: PWY-7210|Reactome: R-HSA-499943|Reactome: R-HSA-539107 pp2_031 cd31ee6a5b9de6e12f33f9cd48a461c7 299 TIGRFAM TIGR03284 thym_sym: thymidylate synthase 2 298 1.2E-74 T 30-10-2018 IPR000398 Thymidylate synthase GO:0004799|GO:0006231 KEGG: 00240+2.1.1.45|KEGG: 00670+2.1.1.45|MetaCyc: PWY-3841|MetaCyc: PWY-7184|MetaCyc: PWY-7187|MetaCyc: PWY-7198|MetaCyc: PWY-7199|MetaCyc: PWY-7210|Reactome: R-HSA-499943|Reactome: R-HSA-539107 pp2_031 cd31ee6a5b9de6e12f33f9cd48a461c7 299 Pfam PF00303 Thymidylate synthase 2 299 6.6E-83 T 30-10-2018 IPR023451 Thymidylate synthase/dCMP hydroxymethylase domain KEGG: 00240+2.1.1.45|KEGG: 00670+2.1.1.45|MetaCyc: PWY-3841|MetaCyc: PWY-7184|MetaCyc: PWY-7187|MetaCyc: PWY-7198|MetaCyc: PWY-7199|MetaCyc: PWY-7210|Reactome: R-HSA-499943|Reactome: R-HSA-539107 pp2_031 cd31ee6a5b9de6e12f33f9cd48a461c7 299 PRINTS PR00108 Thymidylate synthase family signature 175 190 7.9E-29 T 30-10-2018 IPR000398 Thymidylate synthase GO:0004799|GO:0006231 KEGG: 00240+2.1.1.45|KEGG: 00670+2.1.1.45|MetaCyc: PWY-3841|MetaCyc: PWY-7184|MetaCyc: PWY-7187|MetaCyc: PWY-7198|MetaCyc: PWY-7199|MetaCyc: PWY-7210|Reactome: R-HSA-499943|Reactome: R-HSA-539107 pp2_031 cd31ee6a5b9de6e12f33f9cd48a461c7 299 PRINTS PR00108 Thymidylate synthase family signature 193 219 7.9E-29 T 30-10-2018 IPR000398 Thymidylate synthase GO:0004799|GO:0006231 KEGG: 00240+2.1.1.45|KEGG: 00670+2.1.1.45|MetaCyc: PWY-3841|MetaCyc: PWY-7184|MetaCyc: PWY-7187|MetaCyc: PWY-7198|MetaCyc: PWY-7199|MetaCyc: PWY-7210|Reactome: R-HSA-499943|Reactome: R-HSA-539107 pp2_031 cd31ee6a5b9de6e12f33f9cd48a461c7 299 PRINTS PR00108 Thymidylate synthase family signature 231 248 7.9E-29 T 30-10-2018 IPR000398 Thymidylate synthase GO:0004799|GO:0006231 KEGG: 00240+2.1.1.45|KEGG: 00670+2.1.1.45|MetaCyc: PWY-3841|MetaCyc: PWY-7184|MetaCyc: PWY-7187|MetaCyc: PWY-7198|MetaCyc: PWY-7199|MetaCyc: PWY-7210|Reactome: R-HSA-499943|Reactome: R-HSA-539107 pp2_031 cd31ee6a5b9de6e12f33f9cd48a461c7 299 PRINTS PR00108 Thymidylate synthase family signature 42 63 7.9E-29 T 30-10-2018 IPR000398 Thymidylate synthase GO:0004799|GO:0006231 KEGG: 00240+2.1.1.45|KEGG: 00670+2.1.1.45|MetaCyc: PWY-3841|MetaCyc: PWY-7184|MetaCyc: PWY-7187|MetaCyc: PWY-7198|MetaCyc: PWY-7199|MetaCyc: PWY-7210|Reactome: R-HSA-499943|Reactome: R-HSA-539107 pp2_031 cd31ee6a5b9de6e12f33f9cd48a461c7 299 SUPERFAMILY SSF55831 1 299 1.7E-83 T 30-10-2018 IPR036926 Thymidylate synthase/dCMP hydroxymethylase superfamily KEGG: 00240+2.1.1.45|KEGG: 00670+2.1.1.45|MetaCyc: PWY-3841|MetaCyc: PWY-7184|MetaCyc: PWY-7187|MetaCyc: PWY-7198|MetaCyc: PWY-7199|MetaCyc: PWY-7210|Reactome: R-HSA-499943|Reactome: R-HSA-539107 pp2_208 b3157e36a6974a0a5f3a3da0023e6d64 326 Pfam PF13521 AAA domain 154 308 1.9E-28 T 30-10-2018 IPR038727 NadR/Ttd14, AAA domain pp2_208 b3157e36a6974a0a5f3a3da0023e6d64 326 SUPERFAMILY SSF52374 3 145 1.58E-12 T 30-10-2018 pp2_208 b3157e36a6974a0a5f3a3da0023e6d64 326 Gene3D G3DSA:3.40.50.620 2 149 6.0E-22 T 30-10-2018 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold pp2_208 b3157e36a6974a0a5f3a3da0023e6d64 326 TIGRFAM TIGR00125 cyt_tran_rel: cytidyltransferase-like domain 5 40 1.2E-8 T 30-10-2018 IPR004821 Cytidyltransferase-like domain GO:0003824|GO:0009058 pp2_208 b3157e36a6974a0a5f3a3da0023e6d64 326 SUPERFAMILY SSF52540 151 284 1.2E-7 T 30-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase pp2_208 b3157e36a6974a0a5f3a3da0023e6d64 326 Gene3D G3DSA:3.40.50.300 152 313 3.7E-27 T 30-10-2018 pp2_378 1a9269906c46e1c515a3a4cce656f8e5 56 ProDom PD051653 UVSY.-2 T4 UVSW-UVSY UVSY.2-LIKE 4 54 1.0E-22 T 30-10-2018 pp2_378 1a9269906c46e1c515a3a4cce656f8e5 56 Pfam PF10886 Protein of unknown function (DUF2685) 1 55 6.1E-38 T 30-10-2018 IPR024362 Protein of unknown function DUF2685 pp2_015 8a29a7fa764327121a1948ca81cef8e1 158 ProSitePatterns PS01087 Radical activating enzymes signature. 14 35 - T 30-10-2018 IPR001989 Radical-activating enzyme, conserved site GO:0016491|GO:0051539|GO:0055114 pp2_015 8a29a7fa764327121a1948ca81cef8e1 158 Pfam PF13353 4Fe-4S single cluster domain 12 143 9.4E-42 T 30-10-2018 pp2_015 8a29a7fa764327121a1948ca81cef8e1 158 Gene3D G3DSA:3.20.20.70 2 152 4.0E-21 T 30-10-2018 IPR013785 Aldolase-type TIM barrel GO:0003824 pp2_015 8a29a7fa764327121a1948ca81cef8e1 158 TIGRFAM TIGR02491 NrdG: anaerobic ribonucleoside-triphosphate reductase activating protein 2 144 1.4E-52 T 30-10-2018 IPR012837 Ribonucleoside-triphosphate reductase activating, anaerobic GO:0005737|GO:0043365|GO:0051539|GO:0055114 pp2_015 8a29a7fa764327121a1948ca81cef8e1 158 PIRSF PIRSF000368 1 156 2.0E-55 T 30-10-2018 IPR012837 Ribonucleoside-triphosphate reductase activating, anaerobic GO:0005737|GO:0043365|GO:0051539|GO:0055114 pp2_015 8a29a7fa764327121a1948ca81cef8e1 158 SUPERFAMILY SSF102114 22 101 4.97E-9 T 30-10-2018 pp2_011 32d33e4aaa270d9febf0e25b0cf08df4 81 SUPERFAMILY SSF52833 4 65 1.49E-6 T 30-10-2018 IPR036249 Thioredoxin-like superfamily pp2_011 32d33e4aaa270d9febf0e25b0cf08df4 81 Gene3D G3DSA:3.40.30.10 2 78 3.8E-7 T 30-10-2018 pp2_212 5a7ad42d344e7ffdf330f03a63f68235 221 Pfam PF04973 Nicotinamide mononucleotide transporter 23 212 3.7E-46 T 30-10-2018 IPR006419 Nicotinamide mononucleotide transporter PnuC GO:0016020|GO:0034257|GO:0034258 pp2_212 5a7ad42d344e7ffdf330f03a63f68235 221 TIGRFAM TIGR01528 NMN_trans_PnuC: nicotinamide mononucleotide transporter PnuC 23 213 6.5E-33 T 30-10-2018 IPR006419 Nicotinamide mononucleotide transporter PnuC GO:0016020|GO:0034257|GO:0034258 pp2_345 b3d48bfffd7e986574ee835ea5268168 748 SUPERFAMILY SSF50017 1 285 3.27E-65 T 30-10-2018 IPR036240 Gp9-like superfamily GO:0019076|GO:0098025 pp2_345 b3d48bfffd7e986574ee835ea5268168 748 Gene3D G3DSA:1.20.5.960 12 46 3.1E-7 T 30-10-2018 pp2_345 b3d48bfffd7e986574ee835ea5268168 748 Pfam PF07880 Bacteriophage T4 gp9/10-like protein 2 183 3.1E-26 T 30-10-2018 IPR008987 Baseplate structural protein Gp9/Gp10 GO:0019076|GO:0098025 pp2_343 b34b2e82ea3ce1f04e640792ef880a1c 340 Gene3D G3DSA:2.60.340.10 9 340 3.0E-175 T 30-10-2018 pp2_343 b34b2e82ea3ce1f04e640792ef880a1c 340 Pfam PF09215 Bacteriophage T4, Gp8 7 340 1.0E-206 T 30-10-2018 IPR015298 Bacteriophage T4, Gp8 pp2_343 b34b2e82ea3ce1f04e640792ef880a1c 340 SUPERFAMILY SSF89433 4 340 4.18E-127 T 30-10-2018 IPR036327 Bacteriophage T4, Gp8 superfamily pp2_343 b34b2e82ea3ce1f04e640792ef880a1c 340 Gene3D G3DSA:2.170.290.10 85 251 3.0E-175 T 30-10-2018 pp2_001 2bdf9acf8110ce0df8d5ef940c68f20b 310 Pfam PF09293 T4 RNase H, C terminal 188 310 7.5E-70 T 30-10-2018 IPR036276 T4 RNase H, C-terminal pp2_001 2bdf9acf8110ce0df8d5ef940c68f20b 310 Gene3D G3DSA:1.10.150.20 188 264 2.9E-110 T 30-10-2018 pp2_001 2bdf9acf8110ce0df8d5ef940c68f20b 310 SUPERFAMILY SSF88723 20 192 3.48E-35 T 30-10-2018 IPR029060 PIN-like domain superfamily pp2_001 2bdf9acf8110ce0df8d5ef940c68f20b 310 Pfam PF02739 5'-3' exonuclease, N-terminal resolvase-like domain 54 178 2.0E-13 T 30-10-2018 IPR020046 5'-3' exonuclease, alpha-helical arch, N-terminal GO:0003677 pp2_001 2bdf9acf8110ce0df8d5ef940c68f20b 310 Gene3D G3DSA:3.40.50.1010 23 296 2.9E-110 T 30-10-2018 pp2_001 2bdf9acf8110ce0df8d5ef940c68f20b 310 SUPERFAMILY SSF47807 188 310 3.77E-44 T 30-10-2018 IPR036279 5'-3' exonuclease, C-terminal domain superfamily pp2_057 f652aed791e740421afc5ef8d6078d99 554 Gene3D G3DSA:3.90.176.10 276 497 3.5E-5 T 30-10-2018 pp2_057 f652aed791e740421afc5ef8d6078d99 554 SUPERFAMILY SSF56399 325 503 2.88E-15 T 30-10-2018 pp2_116 9114c6a448a34ee99f005322f32bb96a 150 SUPERFAMILY SSF53927 10 147 4.85E-39 T 30-10-2018 IPR016193 Cytidine deaminase-like GO:0003824 pp2_116 9114c6a448a34ee99f005322f32bb96a 150 PIRSF PIRSF006019 2 150 2.7E-52 T 30-10-2018 IPR016473 Deoxycytidylate deaminase GO:0004132|GO:0006220|GO:0008270 KEGG: 00240+3.5.4.12|MetaCyc: PWY-7210|Reactome: R-HSA-499943 pp2_116 9114c6a448a34ee99f005322f32bb96a 150 ProSitePatterns PS00903 Cytidine and deoxycytidylate deaminases zinc-binding region signature. 77 112 - T 30-10-2018 IPR016192 APOBEC/CMP deaminase, zinc-binding GO:0008270|GO:0016787 pp2_116 9114c6a448a34ee99f005322f32bb96a 150 Gene3D G3DSA:3.40.140.10 8 150 1.3E-39 T 30-10-2018 pp2_116 9114c6a448a34ee99f005322f32bb96a 150 Pfam PF00383 Cytidine and deoxycytidylate deaminase zinc-binding region 13 123 2.9E-28 T 30-10-2018 IPR002125 Cytidine and deoxycytidylate deaminase domain pp2_280 eea95b6b9c4dc7c9bab727879419bbf3 428 SUPERFAMILY SSF56719 3 427 2.49E-94 T 30-10-2018 IPR013760 DNA topoisomerase, type IIA-like domain superfamily GO:0003918|GO:0005524 Reactome: R-HSA-4615885 pp2_280 eea95b6b9c4dc7c9bab727879419bbf3 428 Pfam PF00521 DNA gyrase/topoisomerase IV, subunit A 24 424 2.2E-77 T 30-10-2018 IPR002205 DNA topoisomerase, type IIA, subunit A/C-terminal GO:0003677|GO:0003918|GO:0005524|GO:0006265 Reactome: R-HSA-4615885 pp2_280 eea95b6b9c4dc7c9bab727879419bbf3 428 Gene3D G3DSA:1.10.268.10 326 413 4.3E-92 T 30-10-2018 IPR013757 Type IIA DNA topoisomerase subunit A, alpha-helical domain superfamily GO:0003677|GO:0003918|GO:0005524 Reactome: R-HSA-4615885 pp2_280 eea95b6b9c4dc7c9bab727879419bbf3 428 Gene3D G3DSA:3.90.199.10 29 427 4.3E-92 T 30-10-2018 IPR013758 DNA topoisomerase, type IIA, subunit A/ C-terminal, alpha-beta GO:0003677|GO:0003918|GO:0005524|GO:0006259|GO:0006265 Reactome: R-HSA-4615885 pp2_280 eea95b6b9c4dc7c9bab727879419bbf3 428 Gene3D G3DSA:3.30.1360.40 198 290 4.3E-92 T 30-10-2018 pp2_280 eea95b6b9c4dc7c9bab727879419bbf3 428 SMART SM00434 3 423 1.9E-73 T 30-10-2018 IPR002205 DNA topoisomerase, type IIA, subunit A/C-terminal GO:0003677|GO:0003918|GO:0005524|GO:0006265 Reactome: R-HSA-4615885 pp2_380 9031d17074d207304f6995a7318c87ed 137 Pfam PF09424 Yqey-like protein 13 132 6.7E-16 T 30-10-2018 IPR019004 Uncharacterised protein YqeY/AIM41 pp2_380 9031d17074d207304f6995a7318c87ed 137 Gene3D G3DSA:1.10.10.410 81 134 5.0E-9 T 30-10-2018 IPR023168 Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B, C-terminal pp2_380 9031d17074d207304f6995a7318c87ed 137 SUPERFAMILY SSF89095 2 133 1.41E-19 T 30-10-2018 IPR003789 Aspartyl/glutamyl-tRNA amidotransferase subunit B-like GO:0016884 pp2_144 371bc9647090a5c7cb3f1c2eed902ffb 228 Gene3D G3DSA:1.10.287.70 1 116 1.6E-15 T 30-10-2018 pp2_144 371bc9647090a5c7cb3f1c2eed902ffb 228 SUPERFAMILY SSF81324 20 124 4.84E-17 T 30-10-2018 pp2_144 371bc9647090a5c7cb3f1c2eed902ffb 228 Pfam PF07885 Ion channel 39 110 3.0E-8 T 30-10-2018 IPR013099 Potassium channel domain pp2_081 ee8e39f80835dea8664deb0c30fcf1a6 850 Gene3D G3DSA:1.20.1280.300 680 832 2.0E-50 T 30-10-2018 pp2_081 ee8e39f80835dea8664deb0c30fcf1a6 850 PRINTS PR00106 DNA-directed DNA-polymerase family B signature 389 402 1.2E-9 T 30-10-2018 IPR006172 DNA-directed DNA polymerase, family B GO:0000166|GO:0003676|GO:0003887 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 pp2_081 ee8e39f80835dea8664deb0c30fcf1a6 850 PRINTS PR00106 DNA-directed DNA-polymerase family B signature 517 529 1.2E-9 T 30-10-2018 IPR006172 DNA-directed DNA polymerase, family B GO:0000166|GO:0003676|GO:0003887 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 pp2_081 ee8e39f80835dea8664deb0c30fcf1a6 850 PRINTS PR00106 DNA-directed DNA-polymerase family B signature 578 586 1.2E-9 T 30-10-2018 IPR006172 DNA-directed DNA polymerase, family B GO:0000166|GO:0003676|GO:0003887 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 pp2_081 ee8e39f80835dea8664deb0c30fcf1a6 850 SMART SM00486 101 592 8.0E-75 T 30-10-2018 IPR006172 DNA-directed DNA polymerase, family B GO:0000166|GO:0003676|GO:0003887 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 pp2_081 ee8e39f80835dea8664deb0c30fcf1a6 850 Pfam PF00136 DNA polymerase family B 350 709 3.6E-39 T 30-10-2018 IPR006134 DNA-directed DNA polymerase, family B, multifunctional domain GO:0000166|GO:0003677 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 pp2_081 ee8e39f80835dea8664deb0c30fcf1a6 850 Gene3D G3DSA:3.30.342.10 4 363 5.3E-144 T 30-10-2018 pp2_081 ee8e39f80835dea8664deb0c30fcf1a6 850 Gene3D G3DSA:1.10.287.690 456 533 2.4E-116 T 30-10-2018 pp2_081 ee8e39f80835dea8664deb0c30fcf1a6 850 Hamap MF_04100 DNA-directed DNA polymerase. 1 850 20.273 T 30-10-2018 IPR034749 DNA-directed DNA polymerase T4 type GO:0003677|GO:0003887|GO:0008408|GO:0039693 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 pp2_081 ee8e39f80835dea8664deb0c30fcf1a6 850 ProSitePatterns PS00116 DNA polymerase family B signature. 580 588 - T 30-10-2018 IPR017964 DNA-directed DNA polymerase, family B, conserved site GO:0000166|GO:0003676|GO:0003887 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 pp2_081 ee8e39f80835dea8664deb0c30fcf1a6 850 Gene3D G3DSA:3.90.1600.20 373 679 2.4E-116 T 30-10-2018 pp2_081 ee8e39f80835dea8664deb0c30fcf1a6 850 SUPERFAMILY SSF56672 359 849 1.45E-107 T 30-10-2018 pp2_081 ee8e39f80835dea8664deb0c30fcf1a6 850 Gene3D G3DSA:3.40.1820.10 727 815 2.0E-50 T 30-10-2018 pp2_081 ee8e39f80835dea8664deb0c30fcf1a6 850 SUPERFAMILY SSF53098 4 356 1.14E-66 T 30-10-2018 IPR012337 Ribonuclease H-like superfamily pp2_081 ee8e39f80835dea8664deb0c30fcf1a6 850 Gene3D G3DSA:3.30.420.10 104 324 5.3E-144 T 30-10-2018 IPR036397 Ribonuclease H superfamily GO:0003676 pp2_081 ee8e39f80835dea8664deb0c30fcf1a6 850 Pfam PF03104 DNA polymerase family B, exonuclease domain 97 274 4.5E-23 T 30-10-2018 IPR006133 DNA-directed DNA polymerase, family B, exonuclease domain KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 pp2_377 4cafa3e8aac19d5c75104e09bb790670 507 Gene3D G3DSA:3.40.50.300 296 507 5.5E-47 T 30-10-2018 pp2_377 4cafa3e8aac19d5c75104e09bb790670 507 Pfam PF04851 Type III restriction enzyme, res subunit 127 260 2.8E-16 T 30-10-2018 IPR006935 Helicase/UvrB, N-terminal GO:0003677|GO:0005524|GO:0016787 pp2_377 4cafa3e8aac19d5c75104e09bb790670 507 Pfam PF00271 Helicase conserved C-terminal domain 339 445 4.6E-7 T 30-10-2018 IPR001650 Helicase, C-terminal pp2_377 4cafa3e8aac19d5c75104e09bb790670 507 SMART SM00490 362 446 0.0047 T 30-10-2018 IPR001650 Helicase, C-terminal pp2_377 4cafa3e8aac19d5c75104e09bb790670 507 SUPERFAMILY SSF52540 130 498 6.89E-19 T 30-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase pp2_377 4cafa3e8aac19d5c75104e09bb790670 507 SMART SM00487 111 300 9.5E-18 T 30-10-2018 IPR014001 Helicase superfamily 1/2, ATP-binding domain pp2_377 4cafa3e8aac19d5c75104e09bb790670 507 Gene3D G3DSA:3.30.780.20 2 91 1.3E-25 T 30-10-2018 pp2_377 4cafa3e8aac19d5c75104e09bb790670 507 SUPERFAMILY SSF52540 3 279 5.33E-50 T 30-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase pp2_377 4cafa3e8aac19d5c75104e09bb790670 507 Gene3D G3DSA:3.40.50.300 92 282 6.9E-69 T 30-10-2018 pp2_049 2950dbeee2cd962048bec8ac45288f89 242 SUPERFAMILY SSF56300 3 232 1.52E-20 T 30-10-2018 pp2_049 2950dbeee2cd962048bec8ac45288f89 242 Gene3D G3DSA:3.60.21.10 2 242 5.2E-14 T 30-10-2018 IPR029052 Metallo-dependent phosphatase-like pp2_049 2950dbeee2cd962048bec8ac45288f89 242 Pfam PF12850 Calcineurin-like phosphoesterase superfamily domain 5 225 8.5E-8 T 30-10-2018 IPR024654 Calcineurin-like phosphoesterase domain, lpxH type Reactome: R-HSA-3238698 pp2_275 146e85184636a740631ab1c733c865d9 374 Gene3D G3DSA:1.10.620.20 2 338 5.7E-127 T 30-10-2018 IPR012348 Ribonucleotide reductase-like GO:0016491|GO:0055114 Reactome: R-HSA-499943 pp2_275 146e85184636a740631ab1c733c865d9 374 SUPERFAMILY SSF47240 3 339 6.9E-96 T 30-10-2018 IPR009078 Ferritin-like superfamily pp2_275 146e85184636a740631ab1c733c865d9 374 Pfam PF00268 Ribonucleotide reductase, small chain 31 328 6.7E-42 T 30-10-2018 IPR000358 Ribonucleotide reductase small subunit family GO:0055114 KEGG: 00230+1.17.4.1|KEGG: 00240+1.17.4.1|KEGG: 00480+1.17.4.1|KEGG: 00983+1.17.4.1|MetaCyc: PWY-6545|MetaCyc: PWY-7184|MetaCyc: PWY-7198|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7222|MetaCyc: PWY-7226|MetaCyc: PWY-7227|Reactome: R-HSA-499943 pp2_275 146e85184636a740631ab1c733c865d9 374 ProSitePatterns PS00368 Ribonucleotide reductase small subunit signature. 115 131 - T 30-10-2018 IPR030475 Ribonucleotide reductase small subunit, acitve site KEGG: 00230+1.17.4.1|KEGG: 00240+1.17.4.1|KEGG: 00480+1.17.4.1|KEGG: 00983+1.17.4.1|MetaCyc: PWY-6545|MetaCyc: PWY-7184|MetaCyc: PWY-7198|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7222|MetaCyc: PWY-7226|MetaCyc: PWY-7227|Reactome: R-HSA-499943 pp2_068 6c4457d556c2df9f85d98820939aa4c5 154 Pfam PF08010 Bacteriophage protein GP30.3 8 144 1.8E-73 T 30-10-2018 IPR012596 Bacteriophage T4, Y12G pp2_068 6c4457d556c2df9f85d98820939aa4c5 154 SUPERFAMILY SSF143990 6 149 1.7E-20 T 30-10-2018 IPR037238 YbiA-like superfamily pp2_068 6c4457d556c2df9f85d98820939aa4c5 154 Gene3D G3DSA:1.10.357.40 4 126 5.0E-11 T 30-10-2018 IPR037238 YbiA-like superfamily pp2_335 a6efd746f2bb90fc344459eb3830577e 419 Pfam PF06715 Gp5 C-terminal repeat (3 copies) 361 384 1.7E-5 T 30-10-2018 IPR010609 Gp5, C-terminal pp2_335 a6efd746f2bb90fc344459eb3830577e 419 SUPERFAMILY SSF69349 330 415 1.8E-9 T 30-10-2018 pp2_335 a6efd746f2bb90fc344459eb3830577e 419 Gene3D G3DSA:3.10.450.190 163 250 4.1E-26 T 30-10-2018 pp2_335 a6efd746f2bb90fc344459eb3830577e 419 Pfam PF06714 Gp5 N-terminal OB domain 32 160 3.2E-49 T 30-10-2018 IPR009590 Protein Gp5, N-terminal OB-fold domain GO:0005515|GO:0098025 pp2_335 a6efd746f2bb90fc344459eb3830577e 419 SUPERFAMILY SSF69349 193 355 4.32E-38 T 30-10-2018 pp2_335 a6efd746f2bb90fc344459eb3830577e 419 Gene3D G3DSA:2.40.50.260 1 123 2.7E-42 T 30-10-2018 pp2_335 a6efd746f2bb90fc344459eb3830577e 419 SUPERFAMILY SSF69255 4 123 5.23E-44 T 30-10-2018 pp2_118 8c1b609e5364183f95cc1b77d3214118 224 Hamap MF_00223 GTP cyclohydrolase 1 [folE]. 38 221 31.571 T 30-10-2018 IPR001474 GTP cyclohydrolase I GO:0003934|GO:0005737|GO:0046654 KEGG: 00790+3.5.4.16|MetaCyc: PWY-5663|MetaCyc: PWY-5664|MetaCyc: PWY-6147|MetaCyc: PWY-6703|MetaCyc: PWY-6983|MetaCyc: PWY-7442|MetaCyc: PWY-7852|Reactome: R-HSA-1474151 pp2_118 8c1b609e5364183f95cc1b77d3214118 224 ProSitePatterns PS00859 GTP cyclohydrolase I signature 1. 100 116 - T 30-10-2018 IPR018234 GTP cyclohydrolase I, conserved site GO:0003934|GO:0005737|GO:0046654 KEGG: 00790+3.5.4.16|MetaCyc: PWY-5663|MetaCyc: PWY-5664|MetaCyc: PWY-6147|MetaCyc: PWY-6703|MetaCyc: PWY-6983|MetaCyc: PWY-7442|MetaCyc: PWY-7852|Reactome: R-HSA-1474151 pp2_118 8c1b609e5364183f95cc1b77d3214118 224 Gene3D G3DSA:1.10.286.10 9 88 4.1E-22 T 30-10-2018 pp2_118 8c1b609e5364183f95cc1b77d3214118 224 SUPERFAMILY SSF55620 18 221 1.85E-72 T 30-10-2018 pp2_118 8c1b609e5364183f95cc1b77d3214118 224 Gene3D G3DSA:3.30.1130.10 89 224 2.2E-52 T 30-10-2018 pp2_118 8c1b609e5364183f95cc1b77d3214118 224 ProSitePatterns PS00860 GTP cyclohydrolase I signature 2. 148 158 - T 30-10-2018 IPR018234 GTP cyclohydrolase I, conserved site GO:0003934|GO:0005737|GO:0046654 KEGG: 00790+3.5.4.16|MetaCyc: PWY-5663|MetaCyc: PWY-5664|MetaCyc: PWY-6147|MetaCyc: PWY-6703|MetaCyc: PWY-6983|MetaCyc: PWY-7442|MetaCyc: PWY-7852|Reactome: R-HSA-1474151 pp2_118 8c1b609e5364183f95cc1b77d3214118 224 TIGRFAM TIGR00063 folE: GTP cyclohydrolase I 43 221 2.4E-70 T 30-10-2018 IPR001474 GTP cyclohydrolase I GO:0003934|GO:0005737|GO:0046654 KEGG: 00790+3.5.4.16|MetaCyc: PWY-5663|MetaCyc: PWY-5664|MetaCyc: PWY-6147|MetaCyc: PWY-6703|MetaCyc: PWY-6983|MetaCyc: PWY-7442|MetaCyc: PWY-7852|Reactome: R-HSA-1474151 pp2_118 8c1b609e5364183f95cc1b77d3214118 224 Pfam PF01227 GTP cyclohydrolase I 43 220 1.9E-61 T 30-10-2018 IPR020602 GTP cyclohydrolase I domain KEGG: 00790+3.5.4.16|MetaCyc: PWY-5663|MetaCyc: PWY-5664|MetaCyc: PWY-6147|MetaCyc: PWY-6703|MetaCyc: PWY-6983|MetaCyc: PWY-7442|MetaCyc: PWY-7852|Reactome: R-HSA-1474151 pp2_007 999bc7f1eb41c8a3a26a99615020468f 239 Gene3D G3DSA:3.90.226.10 15 172 2.5E-23 T 30-10-2018 pp2_007 999bc7f1eb41c8a3a26a99615020468f 239 SUPERFAMILY SSF52096 20 167 2.78E-23 T 30-10-2018 IPR029045 ClpP/crotonase-like domain superfamily pp2_007 999bc7f1eb41c8a3a26a99615020468f 239 Pfam PF00574 Clp protease 35 143 5.1E-12 T 30-10-2018 IPR023562 Clp protease proteolytic subunit /Translocation-enhancing protein TepA pp2_020 76bcafbf90a66a1d0aefa4918e467d86 352 SUPERFAMILY SSF56731 129 266 4.97E-7 T 30-10-2018 pp2_127 0df8fe4a4a30115fa1df386ff1c84663 112 Pfam PF00166 Chaperonin 10 Kd subunit 5 107 2.3E-19 T 30-10-2018 IPR020818 GroES chaperonin family GO:0005737|GO:0006457 pp2_127 0df8fe4a4a30115fa1df386ff1c84663 112 SUPERFAMILY SSF50129 2 108 4.15E-43 T 30-10-2018 IPR011032 GroES-like superfamily pp2_127 0df8fe4a4a30115fa1df386ff1c84663 112 PIRSF PIRSF004380 1 109 1.7E-49 T 30-10-2018 IPR016416 Bacteriophage T4, Gp31, chaperonin-GroEL pp2_127 0df8fe4a4a30115fa1df386ff1c84663 112 Gene3D G3DSA:2.30.33.40 1 108 9.3E-42 T 30-10-2018 IPR037124 GroES chaperonin superfamily GO:0005737|GO:0006457 pp2_121 85ba6c038890c2ad088805d7a9487596 302 Pfam PF14819 Nitrile reductase, 7-cyano-7-deazaguanine-reductase N-term 32 139 1.4E-28 T 30-10-2018 IPR029139 NADPH-dependent 7-cyano-7-deazaguanine reductase, N-terminal KEGG: 00790+1.7.1.13|MetaCyc: PWY-6700 pp2_121 85ba6c038890c2ad088805d7a9487596 302 Gene3D G3DSA:3.30.1130.10 157 288 3.1E-36 T 30-10-2018 pp2_121 85ba6c038890c2ad088805d7a9487596 302 SUPERFAMILY SSF55620 185 271 3.63E-10 T 30-10-2018 pp2_121 85ba6c038890c2ad088805d7a9487596 302 PIRSF PIRSF004750 6 292 3.0E-106 T 30-10-2018 IPR016428 NADPH-dependent 7-cyano-7-deazaguanine reductase, QueF type 2 GO:0005737|GO:0008616|GO:0046857|GO:0055114 KEGG: 00790+1.7.1.13|MetaCyc: PWY-6700 pp2_121 85ba6c038890c2ad088805d7a9487596 302 Gene3D G3DSA:3.30.1130.10 28 147 5.1E-34 T 30-10-2018 pp2_121 85ba6c038890c2ad088805d7a9487596 302 Pfam PF14489 QueF-like protein 203 280 9.7E-18 T 30-10-2018 IPR029500 NADPH-dependent 7-cyano-7-deazaguanine reductase QueF GO:0008616|GO:0033739 KEGG: 00790+1.7.1.13|MetaCyc: PWY-6700 pp2_122 96e1fec79874f700d7a36930aae770c1 238 TIGRFAM TIGR00364 TIGR00364: queuosine biosynthesis protein QueC 4 208 1.3E-51 T 30-10-2018 IPR018317 Queuosine biosynthesis protein QueC KEGG: 00790+6.3.4.20|MetaCyc: PWY-6703 pp2_122 96e1fec79874f700d7a36930aae770c1 238 Pfam PF06508 Queuosine biosynthesis protein QueC 2 214 8.4E-54 T 30-10-2018 IPR018317 Queuosine biosynthesis protein QueC KEGG: 00790+6.3.4.20|MetaCyc: PWY-6703 pp2_122 96e1fec79874f700d7a36930aae770c1 238 PIRSF PIRSF006293 1 226 3.8E-57 T 30-10-2018 IPR018317 Queuosine biosynthesis protein QueC KEGG: 00790+6.3.4.20|MetaCyc: PWY-6703 pp2_122 96e1fec79874f700d7a36930aae770c1 238 Gene3D G3DSA:3.40.50.620 1 220 3.1E-55 T 30-10-2018 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold pp2_122 96e1fec79874f700d7a36930aae770c1 238 SUPERFAMILY SSF52402 1 225 1.9E-50 T 30-10-2018 pp2_142 2d9eb07f43792bebebb1dc49983fea42 345 ProDom PD130832 RIIB EARLY PROTECTOR PROPHAGE-INDUCED MEMBRANE FROM LYSIS DNA-BINDING RIIA-RIIB DNA 135 339 4.0E-112 T 30-10-2018 pp2_314 16f909e34aab88d966d242f8fbfe7245 149 Pfam PF11645 PD-(D/E)XK endonuclease 3 94 1.0E-8 T 30-10-2018 IPR021671 PD(D/E)XK endonuclease pp2_314 16f909e34aab88d966d242f8fbfe7245 149 Gene3D G3DSA:3.40.1350.10 1 138 4.2E-23 T 30-10-2018 IPR011856 tRNA endonuclease-like domain superfamily GO:0003676|GO:0004518 pp2_052 8af94fd01c8c1d6aca6cfc4c11afbe9f 198 Gene3D G3DSA:3.40.50.1000 9 166 8.4E-8 T 30-10-2018 IPR023214 HAD superfamily pp2_052 8af94fd01c8c1d6aca6cfc4c11afbe9f 198 Gene3D G3DSA:1.10.150.240 21 78 8.4E-8 T 30-10-2018 IPR023198 Phosphoglycolate phosphatase-like, domain 2 pp2_052 8af94fd01c8c1d6aca6cfc4c11afbe9f 198 SUPERFAMILY SSF56784 3 170 7.78E-13 T 30-10-2018 IPR036412 HAD-like superfamily pp2_042 4e7c768393c3a17a05fdacf992b5783e 221 SUPERFAMILY SSF52467 1 206 7.01E-33 T 30-10-2018 IPR029035 DHS-like NAD/FAD-binding domain superfamily pp2_042 4e7c768393c3a17a05fdacf992b5783e 221 Gene3D G3DSA:3.30.1600.10 1 122 2.3E-28 T 30-10-2018 IPR026591 Sirtuin, catalytic core small domain superfamily pp2_042 4e7c768393c3a17a05fdacf992b5783e 221 Pfam PF02146 Sir2 family 1 152 5.6E-16 T 30-10-2018 IPR003000 Sirtuin family GO:0070403 pp2_042 4e7c768393c3a17a05fdacf992b5783e 221 Gene3D G3DSA:3.40.50.1220 39 176 2.3E-28 T 30-10-2018 pp2_012 ef94eca74edc6f727572b78856e3d973 611 Pfam PF13597 Anaerobic ribonucleoside-triphosphate reductase 17 610 6.7E-178 T 30-10-2018 IPR012833 Ribonucleoside-triphosphate reductase, anaerobic GO:0006260|GO:0008998|GO:0016491|GO:0055114 KEGG: 00230+1.1.98.6|KEGG: 00240+1.1.98.6|MetaCyc: PWY-7187|MetaCyc: PWY-7220|MetaCyc: PWY-7222 pp2_012 ef94eca74edc6f727572b78856e3d973 611 SUPERFAMILY SSF51998 22 591 3.97E-189 T 30-10-2018 pp2_012 ef94eca74edc6f727572b78856e3d973 611 ProSitePatterns PS00850 Glycine radical domain signature. 581 589 - T 30-10-2018 IPR019777 Formate C-acetyltransferase glycine radical, conserved site pp2_012 ef94eca74edc6f727572b78856e3d973 611 Gene3D G3DSA:3.20.70.20 22 592 4.6E-221 T 30-10-2018 pp2_012 ef94eca74edc6f727572b78856e3d973 611 TIGRFAM TIGR02487 NrdD: anaerobic ribonucleoside-triphosphate reductase 16 610 2.7E-185 T 30-10-2018 IPR012833 Ribonucleoside-triphosphate reductase, anaerobic GO:0006260|GO:0008998|GO:0016491|GO:0055114 KEGG: 00230+1.1.98.6|KEGG: 00240+1.1.98.6|MetaCyc: PWY-7187|MetaCyc: PWY-7220|MetaCyc: PWY-7222 pp2_268 63da80fc7e4fcedbdf1260e1b95f55db 350 Pfam PF04055 Radical SAM superfamily 99 241 3.8E-10 T 30-10-2018 IPR007197 Radical SAM GO:0003824|GO:0051536 pp2_268 63da80fc7e4fcedbdf1260e1b95f55db 350 Pfam PF13394 4Fe-4S single cluster domain 99 181 1.9E-8 T 30-10-2018 pp2_268 63da80fc7e4fcedbdf1260e1b95f55db 350 SUPERFAMILY SSF102114 91 301 5.3E-26 T 30-10-2018 pp2_268 63da80fc7e4fcedbdf1260e1b95f55db 350 Gene3D G3DSA:3.20.20.70 85 347 3.7E-29 T 30-10-2018 IPR013785 Aldolase-type TIM barrel GO:0003824 pp2_129 e92c7755915b1fc5513d658d56283c03 169 SUPERFAMILY SSF68918 101 154 1.7E-18 T 30-10-2018 IPR036309 T4 recombination endonuclease VII, dimerisation domain superfamily pp2_129 e92c7755915b1fc5513d658d56283c03 169 Gene3D G3DSA:3.40.1800.10 4 77 2.4E-17 T 30-10-2018 IPR038563 Recombination endonuclease VII superfamily pp2_129 e92c7755915b1fc5513d658d56283c03 169 SUPERFAMILY SSF54060 8 99 1.53E-26 T 30-10-2018 pp2_129 e92c7755915b1fc5513d658d56283c03 169 Pfam PF02945 Recombination endonuclease VII 9 93 6.9E-18 T 30-10-2018 IPR004211 Recombination endonuclease VII pp2_129 e92c7755915b1fc5513d658d56283c03 169 Gene3D G3DSA:1.10.720.10 100 152 2.8E-7 T 30-10-2018 pp2_129 e92c7755915b1fc5513d658d56283c03 169 Pfam PF09124 T4 recombination endonuclease VII, dimerisation 101 154 4.8E-33 T 30-10-2018 IPR015208 T4 recombination endonuclease VII, dimerisation pp2_233 4a9640c86c0fe3e54a762b53ef7b2451 274 Gene3D G3DSA:2.40.320.10 62 216 5.0E-12 T 30-10-2018 pp2_233 4a9640c86c0fe3e54a762b53ef7b2451 274 Pfam PF01928 CYTH domain 2 195 4.6E-5 T 30-10-2018 IPR023577 CYTH domain Reactome: R-HSA-196819 pp2_233 4a9640c86c0fe3e54a762b53ef7b2451 274 SMART SM01118 2 213 0.0048 T 30-10-2018 IPR023577 CYTH domain Reactome: R-HSA-196819 pp2_233 4a9640c86c0fe3e54a762b53ef7b2451 274 SUPERFAMILY SSF55154 1 214 3.92E-17 T 30-10-2018 IPR033469 CYTH-like domain superfamily Reactome: R-HSA-196819 pp2_348 3d37e17569b82de798b4169baba8eecd 473 SUPERFAMILY SSF88874 337 471 6.54E-13 T 30-10-2018 pp2_273 3ed479f49be3a79b57507abae869f269 741 Pfam PF02867 Ribonucleotide reductase, barrel domain 217 720 2.7E-108 T 30-10-2018 IPR000788 Ribonucleotide reductase large subunit, C-terminal GO:0006260|GO:0055114 KEGG: 00230+1.17.4.1|KEGG: 00240+1.17.4.1|KEGG: 00480+1.17.4.1|KEGG: 00983+1.17.4.1|MetaCyc: PWY-6545|MetaCyc: PWY-7184|MetaCyc: PWY-7198|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7222|MetaCyc: PWY-7226|MetaCyc: PWY-7227|Reactome: R-HSA-499943 pp2_273 3ed479f49be3a79b57507abae869f269 741 Pfam PF03477 ATP cone domain 1 86 1.2E-12 T 30-10-2018 IPR005144 ATP-cone domain Reactome: R-HSA-499943 pp2_273 3ed479f49be3a79b57507abae869f269 741 SUPERFAMILY SSF51998 216 728 6.1E-146 T 30-10-2018 pp2_273 3ed479f49be3a79b57507abae869f269 741 TIGRFAM TIGR02506 NrdE_NrdA: ribonucleoside-diphosphate reductase, alpha subunit 140 724 7.4E-153 T 30-10-2018 IPR013346 Ribonucleotide reductase, class I , alpha subunit GO:0055114 KEGG: 00230+1.17.4.1|KEGG: 00240+1.17.4.1|KEGG: 00480+1.17.4.1|KEGG: 00983+1.17.4.1|MetaCyc: PWY-6545|MetaCyc: PWY-7184|MetaCyc: PWY-7198|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7222|MetaCyc: PWY-7226|MetaCyc: PWY-7227|Reactome: R-HSA-499943 pp2_273 3ed479f49be3a79b57507abae869f269 741 Pfam PF00317 Ribonucleotide reductase, all-alpha domain 137 213 3.3E-14 T 30-10-2018 IPR013509 Ribonucleotide reductase large subunit, N-terminal GO:0004748|GO:0005524|GO:0006260|GO:0055114 KEGG: 00230+1.17.4.1|KEGG: 00240+1.17.4.1|KEGG: 00480+1.17.4.1|KEGG: 00983+1.17.4.1|MetaCyc: PWY-6545|MetaCyc: PWY-7184|MetaCyc: PWY-7198|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7222|MetaCyc: PWY-7226|MetaCyc: PWY-7227|Reactome: R-HSA-499943 pp2_273 3ed479f49be3a79b57507abae869f269 741 SUPERFAMILY SSF48168 7 215 5.1E-63 T 30-10-2018 IPR008926 Ribonucleotide reductase R1 subunit, N-terminal KEGG: 00230+1.17.4.1|KEGG: 00240+1.17.4.1|KEGG: 00480+1.17.4.1|KEGG: 00983+1.17.4.1|MetaCyc: PWY-6545|MetaCyc: PWY-7184|MetaCyc: PWY-7198|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7222|MetaCyc: PWY-7226|MetaCyc: PWY-7227|Reactome: R-HSA-499943 pp2_273 3ed479f49be3a79b57507abae869f269 741 ProSitePatterns PS00089 Ribonucleotide reductase large subunit signature. 586 608 - T 30-10-2018 IPR000788 Ribonucleotide reductase large subunit, C-terminal GO:0006260|GO:0055114 KEGG: 00230+1.17.4.1|KEGG: 00240+1.17.4.1|KEGG: 00480+1.17.4.1|KEGG: 00983+1.17.4.1|MetaCyc: PWY-6545|MetaCyc: PWY-7184|MetaCyc: PWY-7198|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7222|MetaCyc: PWY-7226|MetaCyc: PWY-7227|Reactome: R-HSA-499943 pp2_273 3ed479f49be3a79b57507abae869f269 741 PRINTS PR01183 Ribonucleotide reductase large chain signature 425 436 1.8E-28 T 30-10-2018 IPR000788 Ribonucleotide reductase large subunit, C-terminal GO:0006260|GO:0055114 KEGG: 00230+1.17.4.1|KEGG: 00240+1.17.4.1|KEGG: 00480+1.17.4.1|KEGG: 00983+1.17.4.1|MetaCyc: PWY-6545|MetaCyc: PWY-7184|MetaCyc: PWY-7198|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7222|MetaCyc: PWY-7226|MetaCyc: PWY-7227|Reactome: R-HSA-499943 pp2_273 3ed479f49be3a79b57507abae869f269 741 PRINTS PR01183 Ribonucleotide reductase large chain signature 526 549 1.8E-28 T 30-10-2018 IPR000788 Ribonucleotide reductase large subunit, C-terminal GO:0006260|GO:0055114 KEGG: 00230+1.17.4.1|KEGG: 00240+1.17.4.1|KEGG: 00480+1.17.4.1|KEGG: 00983+1.17.4.1|MetaCyc: PWY-6545|MetaCyc: PWY-7184|MetaCyc: PWY-7198|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7222|MetaCyc: PWY-7226|MetaCyc: PWY-7227|Reactome: R-HSA-499943 pp2_273 3ed479f49be3a79b57507abae869f269 741 PRINTS PR01183 Ribonucleotide reductase large chain signature 292 311 1.8E-28 T 30-10-2018 IPR000788 Ribonucleotide reductase large subunit, C-terminal GO:0006260|GO:0055114 KEGG: 00230+1.17.4.1|KEGG: 00240+1.17.4.1|KEGG: 00480+1.17.4.1|KEGG: 00983+1.17.4.1|MetaCyc: PWY-6545|MetaCyc: PWY-7184|MetaCyc: PWY-7198|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7222|MetaCyc: PWY-7226|MetaCyc: PWY-7227|Reactome: R-HSA-499943 pp2_273 3ed479f49be3a79b57507abae869f269 741 PRINTS PR01183 Ribonucleotide reductase large chain signature 462 485 1.8E-28 T 30-10-2018 IPR000788 Ribonucleotide reductase large subunit, C-terminal GO:0006260|GO:0055114 KEGG: 00230+1.17.4.1|KEGG: 00240+1.17.4.1|KEGG: 00480+1.17.4.1|KEGG: 00983+1.17.4.1|MetaCyc: PWY-6545|MetaCyc: PWY-7184|MetaCyc: PWY-7198|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7222|MetaCyc: PWY-7226|MetaCyc: PWY-7227|Reactome: R-HSA-499943 pp2_273 3ed479f49be3a79b57507abae869f269 741 PRINTS PR01183 Ribonucleotide reductase large chain signature 499 521 1.8E-28 T 30-10-2018 IPR000788 Ribonucleotide reductase large subunit, C-terminal GO:0006260|GO:0055114 KEGG: 00230+1.17.4.1|KEGG: 00240+1.17.4.1|KEGG: 00480+1.17.4.1|KEGG: 00983+1.17.4.1|MetaCyc: PWY-6545|MetaCyc: PWY-7184|MetaCyc: PWY-7198|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7222|MetaCyc: PWY-7226|MetaCyc: PWY-7227|Reactome: R-HSA-499943 pp2_273 3ed479f49be3a79b57507abae869f269 741 PRINTS PR01183 Ribonucleotide reductase large chain signature 597 624 1.8E-28 T 30-10-2018 IPR000788 Ribonucleotide reductase large subunit, C-terminal GO:0006260|GO:0055114 KEGG: 00230+1.17.4.1|KEGG: 00240+1.17.4.1|KEGG: 00480+1.17.4.1|KEGG: 00983+1.17.4.1|MetaCyc: PWY-6545|MetaCyc: PWY-7184|MetaCyc: PWY-7198|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7222|MetaCyc: PWY-7226|MetaCyc: PWY-7227|Reactome: R-HSA-499943 pp2_273 3ed479f49be3a79b57507abae869f269 741 Gene3D G3DSA:3.20.70.20 73 729 1.2E-144 T 30-10-2018 pp2_072 0326157872aceb0bd0d0ffd3b385b471 745 SUPERFAMILY SSF75712 352 425 1.44E-5 T 30-10-2018 pp2_072 0326157872aceb0bd0d0ffd3b385b471 745 Pfam PF13555 P-loop containing region of AAA domain 21 55 4.9E-7 T 30-10-2018 pp2_072 0326157872aceb0bd0d0ffd3b385b471 745 SUPERFAMILY SSF52540 3 743 1.46E-26 T 30-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase pp2_072 0326157872aceb0bd0d0ffd3b385b471 745 Gene3D G3DSA:3.40.50.300 2 234 6.4E-29 T 30-10-2018 pp2_072 0326157872aceb0bd0d0ffd3b385b471 745 Gene3D G3DSA:3.40.50.300 486 744 1.7E-20 T 30-10-2018 pp2_075 5a1245b2ce8722ef27fc264f36f75b7f 221 SUPERFAMILY SSF55979 1 109 1.19E-34 T 30-10-2018 pp2_075 5a1245b2ce8722ef27fc264f36f75b7f 221 Gene3D G3DSA:3.70.10.10 1 221 1.3E-72 T 30-10-2018 pp2_075 5a1245b2ce8722ef27fc264f36f75b7f 221 SUPERFAMILY SSF55979 114 220 2.35E-29 T 30-10-2018 pp2_075 5a1245b2ce8722ef27fc264f36f75b7f 221 Pfam PF09116 gp45 sliding clamp, C terminal 117 220 1.8E-40 T 30-10-2018 IPR015200 Gp45 sliding clamp, C-terminal GO:0039693 pp2_061 0a17bb6650fdc352b1a1a2d75c434c31 298 Gene3D G3DSA:3.30.2320.40 115 222 1.3E-9 T 30-10-2018 pp2_061 0a17bb6650fdc352b1a1a2d75c434c31 298 Pfam PF07068 Major capsid protein Gp23 196 272 1.4E-5 T 30-10-2018 IPR010762 Capsid protein, T4-like bacteriophage-like GO:0019012|GO:0019028 pp2_061 0a17bb6650fdc352b1a1a2d75c434c31 298 Pfam PF07068 Major capsid protein Gp23 53 129 1.4E-4 T 30-10-2018 IPR010762 Capsid protein, T4-like bacteriophage-like GO:0019012|GO:0019028 pp2_070 afd8a58dfca733bb3562a16e72e5cc3c 346 Gene3D G3DSA:3.60.21.10 1 232 1.7E-19 T 30-10-2018 IPR029052 Metallo-dependent phosphatase-like pp2_070 afd8a58dfca733bb3562a16e72e5cc3c 346 SUPERFAMILY SSF56300 1 231 2.22E-24 T 30-10-2018 pp2_070 afd8a58dfca733bb3562a16e72e5cc3c 346 Pfam PF00149 Calcineurin-like phosphoesterase 1 188 3.1E-7 T 30-10-2018 IPR004843 Calcineurin-like phosphoesterase domain, ApaH type GO:0016787 pp2_279 ca223d4bac80864e4590e6aee302af5e 334 SUPERFAMILY SSF52540 87 307 2.49E-12 T 30-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase pp2_279 ca223d4bac80864e4590e6aee302af5e 334 SMART SM00382 106 254 9.6E-4 T 30-10-2018 IPR003593 AAA+ ATPase domain pp2_324 39e711f98e85278c96a7e5bc8c4d890f 212 SUPERFAMILY SSF52540 1 211 4.78E-15 T 30-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase pp2_324 39e711f98e85278c96a7e5bc8c4d890f 212 Gene3D G3DSA:1.10.238.70 34 128 8.2E-40 T 30-10-2018 IPR023191 Deoxynucleotide monophosphate kinase, N-terminal MetaCyc: PWY-7197 pp2_324 39e711f98e85278c96a7e5bc8c4d890f 212 Gene3D G3DSA:3.40.50.300 2 210 8.2E-40 T 30-10-2018 pp2_358 51b9af4410a82220a0d67f6f16b70fd7 515 Hamap MF_04114 Portal protein. 2 515 35.461 T 30-10-2018 IPR010823 Portal protein Gp20 pp2_358 51b9af4410a82220a0d67f6f16b70fd7 515 Pfam PF07230 Bacteriophage T4-like capsid assembly protein (Gp20) 3 502 4.3E-285 T 30-10-2018 IPR010823 Portal protein Gp20 pp2_150 b877fd4bd762135713b7e1c708609100 124 Pfam PF10686 Protein of unknown function (DUF2493) 4 73 7.0E-23 T 30-10-2018 IPR019627 Mycobacteriophage D29, Gp61 pp2_333 7b00abbe52563ef04756363676331215 192 Pfam PF11246 Base plate wedge protein 53 1 189 8.2E-112 T 30-10-2018 IPR022607 Baseplate wedge protein gp53, bacteriophage T4 pp2_333 7b00abbe52563ef04756363676331215 192 ProDom PD106550 WEDGE BASEPLATE GP53 SUBUNIT STRUCTURAL T4 LATE BASE GP53-LIKE PLATE 1 188 1.0E-107 T 30-10-2018 IPR022607 Baseplate wedge protein gp53, bacteriophage T4 pp2_339 14ac1ddce0dba33c5bfc51c0127fef5f 291 SUPERFAMILY SSF117892 63 207 1.96E-9 T 30-10-2018 IPR036013 Band 7/SPFH domain superfamily pp2_339 14ac1ddce0dba33c5bfc51c0127fef5f 291 Pfam PF01145 SPFH domain / Band 7 family 26 216 1.1E-18 T 30-10-2018 IPR001107 Band 7 domain pp2_282 2335799ec0d24628d917964d83dc1ccd 293 Gene3D G3DSA:3.20.20.70 4 286 2.8E-23 T 30-10-2018 IPR013785 Aldolase-type TIM barrel GO:0003824 pp2_282 2335799ec0d24628d917964d83dc1ccd 293 Pfam PF13394 4Fe-4S single cluster domain 24 163 1.1E-11 T 30-10-2018 pp2_282 2335799ec0d24628d917964d83dc1ccd 293 Hamap MF_00917 7-carboxy-7-deazaguanine synthase [queE]. 3 290 27.98 T 30-10-2018 IPR024924 7-carboxy-7-deazaguanine synthase-like KEGG: 00790+4.3.99.3|MetaCyc: PWY-6703 pp2_282 2335799ec0d24628d917964d83dc1ccd 293 SUPERFAMILY SSF102114 76 253 3.3E-9 T 30-10-2018 pp2_077 ec63009c456791d1d03e5ad9f7143ac1 162 Gene3D G3DSA:1.20.272.50 35 108 5.9E-14 T 30-10-2018 pp2_077 ec63009c456791d1d03e5ad9f7143ac1 162 Pfam PF16790 Bacteriophage clamp loader A subunit 39 152 1.8E-49 T 30-10-2018 IPR031868 Bacteriophage clamp loader A subunit GO:0003677|GO:0006260 pp2_337 8032c611e00c2a87447e7b825d750c45 98 Gene3D G3DSA:2.60.200.60 4 97 8.8E-27 T 30-10-2018 pp2_337 8032c611e00c2a87447e7b825d750c45 98 Pfam PF05488 PAAR motif 12 89 2.3E-11 T 30-10-2018 IPR008727 PAAR motif pp2_002 a028e32d3e16ce21a2fc50251105e6e5 90 Pfam PF11126 Transcriptional regulator DsbA 22 88 3.5E-40 T 30-10-2018 IPR020313 Double-stranded DNA-binding protein pp2_002 a028e32d3e16ce21a2fc50251105e6e5 90 ProDom PD062891 DSBA BINDING DSDNA A DNA DOUBLE-STRANDED T4 DNA-BINDING LATE TRANSCRIPTION 21 87 6.0E-32 T 30-10-2018 IPR020313 Double-stranded DNA-binding protein pp2_018 cf326ff054ffc08cf3d073588ace7e4f 274 Pfam PF11637 ATP-dependant DNA helicase UvsW 14 69 2.8E-35 T 30-10-2018 IPR020975 DNA helicase, ATP-dependent, UvsW pp2_018 cf326ff054ffc08cf3d073588ace7e4f 274 Gene3D G3DSA:1.20.1280.210 2 71 2.2E-9 T 30-10-2018 IPR038341 DNA helicase UvsW superfamily pp2_356 ec17241202e63beace76ebcf6d418b2d 671 Pfam PF04984 Phage tail sheath protein subtilisin-like domain 358 556 6.3E-48 T 30-10-2018 IPR035089 Tail sheath protein, subtilisin-like domain pp2_356 ec17241202e63beace76ebcf6d418b2d 671 Gene3D G3DSA:3.40.50.11780 349 524 3.2E-48 T 30-10-2018 pp2_356 ec17241202e63beace76ebcf6d418b2d 671 Gene3D G3DSA:3.40.50.11780 22 130 2.0E-22 T 30-10-2018 pp2_356 ec17241202e63beace76ebcf6d418b2d 671 Pfam PF17481 Phage tail sheath protein beta-sandwich domain 165 357 1.1E-26 T 30-10-2018 IPR035326 Phage tail sheath protein, beta-sandwich domain pp2_356 ec17241202e63beace76ebcf6d418b2d 671 Pfam PF17482 Phage tail sheath C-terminal domain 560 659 2.9E-21 T 30-10-2018 IPR020287 Tail sheath protein, C-terminal domain pp2_151 b121aa3f4f0b54a93c6be46a000b2689 421 Gene3D G3DSA:2.30.30.780 249 371 6.6E-84 T 30-10-2018 pp2_151 b121aa3f4f0b54a93c6be46a000b2689 421 SUPERFAMILY SSF52540 2 417 3.59E-33 T 30-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase pp2_151 b121aa3f4f0b54a93c6be46a000b2689 421 Gene3D G3DSA:3.40.50.300 173 420 6.6E-84 T 30-10-2018 pp2_151 b121aa3f4f0b54a93c6be46a000b2689 421 Pfam PF13604 AAA domain 3 187 3.7E-33 T 30-10-2018 pp2_151 b121aa3f4f0b54a93c6be46a000b2689 421 Gene3D G3DSA:3.40.50.300 2 167 1.6E-38 T 30-10-2018 pp2_078 5fe60c9a476bba16f1d1983bf15e4401 126 ProDom PD031547 REPRESSOR REGA TRANSLATION REGULATION TRANSLATIONAL RNA-BINDING EARLY GENES REGA-LIKE 3D-STRUCTURE 12 125 5.0E-63 T 30-10-2018 IPR002702 Translation repressor RegA GO:0003723 pp2_078 5fe60c9a476bba16f1d1983bf15e4401 126 SUPERFAMILY SSF55064 7 125 5.62E-56 T 30-10-2018 IPR036516 Translation repressor RegA superfamily GO:0003723 pp2_078 5fe60c9a476bba16f1d1983bf15e4401 126 Pfam PF01818 Bacteriophage translational regulator 7 125 1.4E-70 T 30-10-2018 IPR002702 Translation repressor RegA GO:0003723 pp2_078 5fe60c9a476bba16f1d1983bf15e4401 126 Gene3D G3DSA:3.30.70.650 6 126 1.5E-50 T 30-10-2018 IPR036516 Translation repressor RegA superfamily GO:0003723 pp2_349 cbcc4b30cf5c158468ef2859d7096fb1 559 Gene3D G3DSA:1.20.5.320 6 96 4.8E-16 T 30-10-2018 pp2_349 cbcc4b30cf5c158468ef2859d7096fb1 559 SUPERFAMILY SSF58046 8 110 1.29E-27 T 30-10-2018 pp2_004 45571d76b711647ceb590ebbbe26e428 216 Pfam PF08993 T4 gene Gp59 loader of gp41 DNA helicase 16 108 5.9E-52 T 30-10-2018 IPR015085 Bacteriophage T4, Gp59, helicase assembly protein, N-terminal pp2_004 45571d76b711647ceb590ebbbe26e428 216 Gene3D G3DSA:1.10.8.60 10 108 6.8E-32 T 30-10-2018 pp2_004 45571d76b711647ceb590ebbbe26e428 216 Gene3D G3DSA:1.10.220.50 109 216 6.2E-31 T 30-10-2018 IPR037082 Bacteriophage T4, Gp59, helicase assembly protein, C-terminal domain superfamily pp2_004 45571d76b711647ceb590ebbbe26e428 216 SUPERFAMILY SSF48493 7 215 6.02E-79 T 30-10-2018 IPR023197 Bacteriophage T4, Gp59, helicase assembly protein domain superfamily pp2_004 45571d76b711647ceb590ebbbe26e428 216 Pfam PF08994 T4 gene Gp59 loader of gp41 DNA helicase C-term 115 215 2.1E-43 T 30-10-2018 IPR015086 Bacteriophage T4, Gp59, helicase assembly protein, C-terminal pp2_124 0ac71b5adb89cc58e0b3bd8f96536223 91 ProDom PD068623 ORF GP31.1 GP31-CD B 10 87 1.0E-4 T 30-10-2018 pp2_124 0ac71b5adb89cc58e0b3bd8f96536223 91 Pfam PF10902 WYL_2, Sm-like SH3 beta-barrel fold 6 84 1.9E-23 T 30-10-2018 IPR024401 WYL domain containing protein pp2_055 e3d660322c7b0139dd95ba47f5223c01 447 SUPERFAMILY SSF56091 102 340 2.01E-35 T 30-10-2018 pp2_055 e3d660322c7b0139dd95ba47f5223c01 447 Gene3D G3DSA:2.40.50.140 351 435 1.3E-12 T 30-10-2018 pp2_055 e3d660322c7b0139dd95ba47f5223c01 447 Pfam PF01068 ATP dependent DNA ligase domain 138 340 8.0E-29 T 30-10-2018 IPR012310 DNA ligase, ATP-dependent, central GO:0003910|GO:0005524|GO:0006281|GO:0006310 pp2_055 e3d660322c7b0139dd95ba47f5223c01 447 ProSitePatterns PS00697 ATP-dependent DNA ligase AMP-binding site. 160 168 - T 30-10-2018 IPR016059 DNA ligase, ATP-dependent, conserved site GO:0003909|GO:0051103 pp2_055 e3d660322c7b0139dd95ba47f5223c01 447 SUPERFAMILY SSF50249 314 429 7.28E-25 T 30-10-2018 IPR012340 Nucleic acid-binding, OB-fold pp2_055 e3d660322c7b0139dd95ba47f5223c01 447 Gene3D G3DSA:3.30.470.30 133 341 6.4E-23 T 30-10-2018 pp2_055 e3d660322c7b0139dd95ba47f5223c01 447 ProSitePatterns PS00333 ATP-dependent DNA ligase signature 2. 317 340 - T 30-10-2018 IPR016059 DNA ligase, ATP-dependent, conserved site GO:0003909|GO:0051103 pp2_055 e3d660322c7b0139dd95ba47f5223c01 447 Pfam PF14743 DNA ligase OB-like domain 354 413 1.8E-11 T 30-10-2018 IPR029319 DNA ligase, OB-like domain pp2_088 8cb9fbecb3d1367cfdcac6e21c99d288 385 Pfam PF13671 AAA domain 83 218 1.9E-18 T 30-10-2018 pp2_088 8cb9fbecb3d1367cfdcac6e21c99d288 385 SUPERFAMILY SSF56784 244 385 4.58E-17 T 30-10-2018 IPR036412 HAD-like superfamily pp2_088 8cb9fbecb3d1367cfdcac6e21c99d288 385 Gene3D G3DSA:3.40.50.300 80 222 3.2E-32 T 30-10-2018 pp2_088 8cb9fbecb3d1367cfdcac6e21c99d288 385 Gene3D G3DSA:3.40.50.1000 242 385 5.6E-38 T 30-10-2018 IPR023214 HAD superfamily pp2_088 8cb9fbecb3d1367cfdcac6e21c99d288 385 SUPERFAMILY SSF52540 81 204 9.46E-15 T 30-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase pp2_361 42954779301316ca11b42c8eb9aa7c2f 213 ProDom PD111331 PROTEASE PROHEAD CORE GP21 SCAFFOLD GP21-LIKE AUTOCATALYTIC ALTERNATE PRODUCT T4 38 213 2.0E-98 T 30-10-2018 IPR005082 Peptidase U9, T4 prohead protease pp2_361 42954779301316ca11b42c8eb9aa7c2f 213 Pfam PF03420 Prohead core protein serine protease 5 184 6.3E-91 T 30-10-2018 IPR005082 Peptidase U9, T4 prohead protease pp2_328 cffcdc3370d32e02fe52622229bcfc06 282 Pfam PF12322 T4 bacteriophage base plate protein 15 104 9.5E-13 T 30-10-2018 IPR024364 Baseplate hub assembly protein, bacteriophage T4-like pp2_328 cffcdc3370d32e02fe52622229bcfc06 282 Pfam PF12322 T4 bacteriophage base plate protein 121 281 5.9E-19 T 30-10-2018 IPR024364 Baseplate hub assembly protein, bacteriophage T4-like pp2_135 12c6f4522cb748d61faa1c1850d265d5 192 SUPERFAMILY SSF53335 12 137 6.52E-14 T 30-10-2018 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase pp2_135 12c6f4522cb748d61faa1c1850d265d5 192 Gene3D G3DSA:3.40.50.150 15 189 3.3E-11 T 30-10-2018 pp2_276 03188b2d5312d63fe3f50f0e8cdebcd4 99 Pfam PF00462 Glutaredoxin 2 76 1.1E-13 T 30-10-2018 IPR002109 Glutaredoxin GO:0009055|GO:0015035|GO:0045454 pp2_276 03188b2d5312d63fe3f50f0e8cdebcd4 99 SUPERFAMILY SSF52833 2 85 2.32E-11 T 30-10-2018 IPR036249 Thioredoxin-like superfamily pp2_276 03188b2d5312d63fe3f50f0e8cdebcd4 99 Gene3D G3DSA:3.40.30.10 1 86 1.5E-20 T 30-10-2018 pp2_352 f7637c7d5de8f6c9f46fa91b7310c109 377 Gene3D G3DSA:3.30.2000.40 1 162 4.6E-52 T 30-10-2018 IPR038553 Myoviridae tail sheath stabiliser superfamily pp2_352 f7637c7d5de8f6c9f46fa91b7310c109 377 Pfam PF16724 T4-like virus Myoviridae tail sheath stabiliser 1 158 7.6E-86 T 30-10-2018 IPR031997 Myoviridae tail sheath stabiliser pp2_141 f83f3d042cc44c16c443d92865081dd7 689 Pfam PF13589 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 46 149 1.1E-5 T 30-10-2018 pp2_141 f83f3d042cc44c16c443d92865081dd7 689 Gene3D G3DSA:3.30.565.10 4 210 7.5E-17 T 30-10-2018 IPR036890 Histidine kinase/HSP90-like ATPase superfamily pp2_141 f83f3d042cc44c16c443d92865081dd7 689 SUPERFAMILY SSF55874 30 182 3.2E-14 T 30-10-2018 IPR036890 Histidine kinase/HSP90-like ATPase superfamily pp2_131 16f7796b68c23870f19692ac19c3cb6d 335 Pfam PF09414 RNA ligase 27 222 5.0E-23 T 30-10-2018 IPR021122 RNA ligase domain, REL/Rln2 pp2_131 16f7796b68c23870f19692ac19c3cb6d 335 SUPERFAMILY SSF56091 1 229 5.75E-61 T 30-10-2018 pp2_131 16f7796b68c23870f19692ac19c3cb6d 335 TIGRFAM TIGR02307 RNA_lig_RNL2: RNA ligase, Rnl2 family 3 332 1.3E-141 T 30-10-2018 IPR012647 RNA ligase, Rnl2 GO:0003972|GO:0005524|GO:0016874 pp2_131 16f7796b68c23870f19692ac19c3cb6d 335 Gene3D G3DSA:3.30.1490.70 8 228 2.5E-61 T 30-10-2018 pp2_131 16f7796b68c23870f19692ac19c3cb6d 335 Gene3D G3DSA:3.30.470.30 37 164 2.5E-61 T 30-10-2018 pp2_131 16f7796b68c23870f19692ac19c3cb6d 335 Gene3D G3DSA:1.10.10.1810 242 332 1.1E-29 T 30-10-2018 pp2_006 c2956b2d110ef27472bad4364dff8e15 181 Pfam PF00186 Dihydrofolate reductase 18 161 4.7E-24 T 30-10-2018 IPR001796 Dihydrofolate reductase domain GO:0004146|GO:0046654|GO:0055114 KEGG: 00670+1.5.1.3|KEGG: 00790+1.5.1.3|MetaCyc: PWY-3841|MetaCyc: PWY-6614|Reactome: R-HSA-196757 pp2_006 c2956b2d110ef27472bad4364dff8e15 181 PRINTS PR00070 Dihydrofolate reductase signature 18 28 7.3E-10 T 30-10-2018 pp2_006 c2956b2d110ef27472bad4364dff8e15 181 PRINTS PR00070 Dihydrofolate reductase signature 46 57 7.3E-10 T 30-10-2018 pp2_006 c2956b2d110ef27472bad4364dff8e15 181 PRINTS PR00070 Dihydrofolate reductase signature 109 123 7.3E-10 T 30-10-2018 pp2_006 c2956b2d110ef27472bad4364dff8e15 181 PRINTS PR00070 Dihydrofolate reductase signature 33 41 7.3E-10 T 30-10-2018 pp2_006 c2956b2d110ef27472bad4364dff8e15 181 Gene3D G3DSA:3.40.430.10 2 175 5.2E-37 T 30-10-2018 IPR024072 Dihydrofolate reductase-like domain superfamily Reactome: R-HSA-196757 pp2_006 c2956b2d110ef27472bad4364dff8e15 181 SUPERFAMILY SSF53597 12 164 5.76E-33 T 30-10-2018 IPR024072 Dihydrofolate reductase-like domain superfamily Reactome: R-HSA-196757 pp2_257 c6bb2fe393b3b6a7528946c30c3f70bb 190 SUPERFAMILY SSF56784 1 175 1.18E-12 T 30-10-2018 IPR036412 HAD-like superfamily pp2_117 c07a3ad93311e706ad6495c795422b7b 308 SUPERFAMILY SSF55620 4 162 1.06E-11 T 30-10-2018 pp2_117 c07a3ad93311e706ad6495c795422b7b 308 Pfam PF01242 6-pyruvoyl tetrahydropterin synthase 172 291 3.2E-5 T 30-10-2018 IPR007115 6-pyruvoyl tetrahydropterin synthase/QueD family Reactome: R-HSA-1474151 pp2_117 c07a3ad93311e706ad6495c795422b7b 308 SUPERFAMILY SSF55620 172 294 1.61E-12 T 30-10-2018 pp2_117 c07a3ad93311e706ad6495c795422b7b 308 Gene3D G3DSA:3.30.479.10 19 165 1.1E-10 T 30-10-2018 IPR038418 6-pyruvoyl tetrahydropterin synthase/QueD superfamily Reactome: R-HSA-1474151 pp2_157 111439d11db392aaaff547be3bcf1ece 341 Pfam PF00293 NUDIX domain 212 338 6.6E-17 T 30-10-2018 IPR000086 NUDIX hydrolase domain GO:0016787 pp2_157 111439d11db392aaaff547be3bcf1ece 341 ProSitePatterns PS00893 Nudix box signature. 233 254 - T 30-10-2018 IPR020084 NUDIX hydrolase, conserved site GO:0016787 pp2_157 111439d11db392aaaff547be3bcf1ece 341 Gene3D G3DSA:3.90.79.10 200 339 3.4E-35 T 30-10-2018 pp2_157 111439d11db392aaaff547be3bcf1ece 341 SUPERFAMILY SSF55811 189 338 5.96E-24 T 30-10-2018 IPR015797 NUDIX hydrolase-like domain superfamily GO:0016787 pp2_157 111439d11db392aaaff547be3bcf1ece 341 Gene3D G3DSA:3.40.50.620 1 192 6.1E-42 T 30-10-2018 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold pp2_157 111439d11db392aaaff547be3bcf1ece 341 SUPERFAMILY SSF52374 4 167 2.72E-17 T 30-10-2018 pp2_157 111439d11db392aaaff547be3bcf1ece 341 TIGRFAM TIGR00125 cyt_tran_rel: cytidyltransferase-like domain 4 59 4.6E-9 T 30-10-2018 IPR004821 Cytidyltransferase-like domain GO:0003824|GO:0009058 pp2_157 111439d11db392aaaff547be3bcf1ece 341 Pfam PF01467 Cytidylyltransferase-like 5 56 4.1E-6 T 30-10-2018 IPR004821 Cytidyltransferase-like domain GO:0003824|GO:0009058 pp2_005 e97dcb8882abe4e93cb462a77a2316ba 303 SUPERFAMILY SSF50249 24 237 5.65E-94 T 30-10-2018 IPR012340 Nucleic acid-binding, OB-fold pp2_005 e97dcb8882abe4e93cb462a77a2316ba 303 Pfam PF08804 gp32 DNA binding protein like 28 116 2.8E-49 T 30-10-2018 IPR012339 Bacteriophage T4, Gp32, single-stranded DNA-binding GO:0003697 pp2_005 e97dcb8882abe4e93cb462a77a2316ba 303 Gene3D G3DSA:3.90.198.10 21 252 5.7E-88 T 30-10-2018 pp2_293 18352b13942bc607fd008dbae22fca58 99 Pfam PF09010 Anti-Sigma Factor A 10 94 1.2E-49 T 30-10-2018 IPR015100 Anti-Sigma Factor A GO:0006355 pp2_293 18352b13942bc607fd008dbae22fca58 99 Gene3D G3DSA:1.10.1810.10 10 95 7.6E-17 T 30-10-2018 IPR036486 Anti-Sigma Factor A superfamily pp2_293 18352b13942bc607fd008dbae22fca58 99 SUPERFAMILY SSF69070 9 98 8.89E-37 T 30-10-2018 IPR036486 Anti-Sigma Factor A superfamily pp2_366 72a0531e6cd11daf28db87da127e374b 484 Gene3D G3DSA:3.30.60.240 39 59 2.3E-8 T 30-10-2018 pp2_366 72a0531e6cd11daf28db87da127e374b 484 Gene3D G3DSA:3.30.60.240 13 36 6.0E-8 T 30-10-2018 pp2_201 b6063a2d4279b607852ff4db448a45d5 138 Pfam PF03013 Pyrimidine dimer DNA glycosylase 1 132 1.7E-42 T 30-10-2018 IPR004260 Pyrimidine dimer DNA glycosylase pp2_201 b6063a2d4279b607852ff4db448a45d5 138 SUPERFAMILY SSF47077 2 130 2.09E-47 T 30-10-2018 pp2_201 b6063a2d4279b607852ff4db448a45d5 138 ProDom PD021350 ENDONUCLEASE PYRIMIDINE GLYCOSYLASE DIMER-SPECIFIC V DNA DENV HYDROLASE V DIMER 12 85 3.0E-37 T 30-10-2018 IPR021143 Pyrimidine dimer DNA glycosylase, endonuclease V type pp2_201 b6063a2d4279b607852ff4db448a45d5 138 PIRSF PIRSF001000 1 136 2.2E-36 T 30-10-2018 IPR021143 Pyrimidine dimer DNA glycosylase, endonuclease V type pp2_201 b6063a2d4279b607852ff4db448a45d5 138 Gene3D G3DSA:1.10.440.10 1 134 1.1E-38 T 30-10-2018 IPR024796 T4 endonuclease V pp2_355 1445e86b1166f62d3d3c6562dcefff5c 600 Pfam PF03237 Terminase-like family 143 355 1.4E-40 T 30-10-2018 IPR004921 Terminase large subunit, T4likevirus-type pp2_355 1445e86b1166f62d3d3c6562dcefff5c 600 Gene3D G3DSA:3.30.420.240 340 557 5.7E-76 T 30-10-2018 pp2_355 1445e86b1166f62d3d3c6562dcefff5c 600 SUPERFAMILY SSF52540 120 290 1.15E-8 T 30-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase pp2_355 1445e86b1166f62d3d3c6562dcefff5c 600 Pfam PF17289 Terminase RNaseH-like domain 384 555 1.3E-47 T 30-10-2018 IPR035421 Terminase, large subunit gp17-like pp2_355 1445e86b1166f62d3d3c6562dcefff5c 600 Gene3D G3DSA:3.40.50.300 43 299 3.7E-76 T 30-10-2018 pp2_109 362b6e1c9c341dc472011fcf80a8514b 94 Pfam PF14216 Domain of unknown function (DUF4326) 5 80 6.6E-26 T 30-10-2018 IPR025475 Protein of unknown function DUF4326) pp2_059 71e750315c1083fbe7aca98a7e972010 270 SMART SM00731 9 150 0.0076 T 30-10-2018 IPR006640 SprT-like pp2_059 71e750315c1083fbe7aca98a7e972010 270 Pfam PF10263 SprT-like family 29 105 7.0E-15 T 30-10-2018 IPR006640 SprT-like pp2_254 711cd88f9b6fed3638b8e2712cd69919 210 SUPERFAMILY SSF51690 84 206 5.41E-5 T 30-10-2018 IPR036068 Nicotinate phosphoribosyltransferase-like, C-terminal GO:0004514|GO:0009435 KEGG: 00760+6.3.4.21|MetaCyc: PWY-5381 pp2_357 6cf6339dbf49466a2bab57176cd4b71b 166 ProDom PD034665 TAIL TUBE GP19 MONOMER STRUCTURAL GP19-LIKE GP19V GP54 SEQUENCING DIRECT 7 163 7.0E-90 T 30-10-2018 pp2_357 6cf6339dbf49466a2bab57176cd4b71b 166 Pfam PF06841 T4-like virus tail tube protein gp19 21 164 1.3E-10 T 30-10-2018 IPR010667 Bacteriophage T4, Gp19, tail tube GO:0005198 pp2_354 2c6c13c8c2c8e49765ffe3890e315c79 182 Pfam PF11053 Terminase DNA packaging enzyme 7 155 7.0E-86 T 30-10-2018 IPR020342 Bacteriophage T4, Gp16, DNA-packaging pp2_354 2c6c13c8c2c8e49765ffe3890e315c79 182 ProDom PD096257 TERMINASE SUBUNIT DNA SMALL PACKAGING ENZYME GP16 GP16V DNA-BINDING GP16-LIKE 6 151 5.0E-81 T 30-10-2018 IPR020342 Bacteriophage T4, Gp16, DNA-packaging pp2_354 2c6c13c8c2c8e49765ffe3890e315c79 182 Gene3D G3DSA:1.10.287.1060 46 123 2.4E-32 T 30-10-2018 pp2_067 8074b8cb2ba54ddfeb0cf80b61e5dbd2 116 Pfam PF10849 Protein of unknown function (DUF2654) 37 105 7.8E-41 T 30-10-2018 IPR022558 Protein of unknown function DUF2654 pp2_067 8074b8cb2ba54ddfeb0cf80b61e5dbd2 116 ProDom PD069849 A-GT.4 ORF A T4 MOBB-GP55 A-GT.4-LIKE 30 105 7.0E-37 T 30-10-2018 IPR022558 Protein of unknown function DUF2654 pp2_260 d25f8f37036c8e422715ac01297d945b 497 Pfam PF04095 Nicotinate phosphoribosyltransferase (NAPRTase) family 177 424 7.6E-52 T 30-10-2018 IPR007229 Nicotinate phosphoribosyltransferase family KEGG: 00760+6.3.4.21|MetaCyc: PWY-5381|Reactome: R-HSA-197264 pp2_260 d25f8f37036c8e422715ac01297d945b 497 Gene3D G3DSA:3.20.20.70 140 398 1.1E-91 T 30-10-2018 IPR013785 Aldolase-type TIM barrel GO:0003824 pp2_260 d25f8f37036c8e422715ac01297d945b 497 PIRSF PIRSF005943 1 486 2.3E-191 T 30-10-2018 IPR016471 Nicotinamide phosphoribosyl transferase Reactome: R-HSA-1368108|Reactome: R-HSA-197264 pp2_260 d25f8f37036c8e422715ac01297d945b 497 SUPERFAMILY SSF51690 143 484 5.49E-39 T 30-10-2018 IPR036068 Nicotinate phosphoribosyltransferase-like, C-terminal GO:0004514|GO:0009435 KEGG: 00760+6.3.4.21|MetaCyc: PWY-5381 pp2_083 c9dfc57b0206ab996e011842806dd1cb 381 TIGRFAM TIGR02308 RNA_lig_T4_1: RNA ligase, T4 RnlA family 4 377 1.8E-124 T 30-10-2018 IPR012648 Bacteriophage T4 RNA ligase Rnl1 GO:0003972 pp2_083 c9dfc57b0206ab996e011842806dd1cb 381 Pfam PF09511 RNA ligase 54 254 7.6E-30 T 30-10-2018 IPR019039 RNA ligase T4 Rnl1, N-terminal pp2_083 c9dfc57b0206ab996e011842806dd1cb 381 Gene3D G3DSA:1.10.3550.20 252 377 1.3E-39 T 30-10-2018 pp2_364 665a25e482326c54175e9a3d1b922334 365 SUPERFAMILY SSF81891 142 357 1.7E-25 T 30-10-2018 pp2_364 665a25e482326c54175e9a3d1b922334 365 Gene3D G3DSA:1.10.3090.10 144 361 2.5E-24 T 30-10-2018 pp2_364 665a25e482326c54175e9a3d1b922334 365 Pfam PF12627 Probable RNA and SrmB- binding site of polymerase A 171 219 1.0E-6 T 30-10-2018 IPR032828 tRNA nucleotidyltransferase/poly(A) polymerase, RNA and SrmB- binding domain Reactome: R-HSA-6784531|Reactome: R-HSA-6785470 pp2_364 665a25e482326c54175e9a3d1b922334 365 Gene3D G3DSA:3.30.460.10 2 143 1.1E-23 T 30-10-2018 pp2_364 665a25e482326c54175e9a3d1b922334 365 SUPERFAMILY SSF81301 8 141 1.31E-20 T 30-10-2018 pp2_364 665a25e482326c54175e9a3d1b922334 365 Pfam PF01743 Poly A polymerase head domain 11 144 1.1E-15 T 30-10-2018 IPR002646 Poly A polymerase, head domain GO:0003723|GO:0006396|GO:0016779 Reactome: R-HSA-6784531|Reactome: R-HSA-6785470 pp2_299 91e5c31384ba18e5b8ac43c7f433f7b9 478 Pfam PF11443 Domain of unknown function (DUF2828) 176 459 2.1E-67 T 30-10-2018 IPR024553 Domain of unknown function DUF2828 pp2_299 91e5c31384ba18e5b8ac43c7f433f7b9 478 Pfam PF11443 Domain of unknown function (DUF2828) 15 93 4.8E-9 T 30-10-2018 IPR024553 Domain of unknown function DUF2828 pp2_299 91e5c31384ba18e5b8ac43c7f433f7b9 478 SUPERFAMILY SSF53300 266 454 2.72E-8 T 30-10-2018 IPR036465 von Willebrand factor A-like domain superfamily pp2_299 91e5c31384ba18e5b8ac43c7f433f7b9 478 PIRSF PIRSF015417 1 124 2.0E-4 T 30-10-2018 IPR011205 Uncharacterised conserved protein UCP015417, vWA pp2_299 91e5c31384ba18e5b8ac43c7f433f7b9 478 PIRSF PIRSF015417 135 403 1.1E-39 T 30-10-2018 IPR011205 Uncharacterised conserved protein UCP015417, vWA pp2_299 91e5c31384ba18e5b8ac43c7f433f7b9 478 PIRSF PIRSF015417 396 478 2.1E-9 T 30-10-2018 IPR011205 Uncharacterised conserved protein UCP015417, vWA pp2_277 444b6fa22206896ec0a98fb25af0e5b6 190 Pfam PF01464 Transglycosylase SLT domain 54 170 2.1E-10 T 30-10-2018 IPR008258 Transglycosylase SLT domain 1 pp2_277 444b6fa22206896ec0a98fb25af0e5b6 190 Gene3D G3DSA:1.10.530.10 45 184 4.4E-9 T 30-10-2018 pp2_277 444b6fa22206896ec0a98fb25af0e5b6 190 SUPERFAMILY SSF53955 50 178 1.9E-13 T 30-10-2018 IPR023346 Lysozyme-like domain superfamily pp2_329 6633f9c4762756ad393d2b2894e6c141 248 Pfam PF06841 T4-like virus tail tube protein gp19 104 207 6.5E-7 T 30-10-2018 IPR010667 Bacteriophage T4, Gp19, tail tube GO:0005198 pp2_329 6633f9c4762756ad393d2b2894e6c141 248 ProDom PD034665 TAIL TUBE GP19 MONOMER STRUCTURAL GP19-LIKE GP19V GP54 SEQUENCING DIRECT 78 189 4.0E-63 T 30-10-2018 pp2_332 37b637c30d493f018ad7fbc461979da1 379 Pfam PF11091 Tail-tube assembly protein 12 342 3.5E-105 T 30-10-2018 IPR024389 Baseplate tail-tube protein gp48, T4-like virus pp2_332 37b637c30d493f018ad7fbc461979da1 379 ProDom PD135082 GP48 BASEPLATE CAP TUBE TAIL GP48-LIKE T4 TAIL-TUBE DIRECT LATE 271 346 3.0E-40 T 30-10-2018 pp2_030 4f48601c80a85e61871bcb163d5eee41 66 TIGRFAM TIGR02532 IV_pilin_GFxxxE: prepilin-type N-terminal cleavage/methylation domain 4 25 3.9E-10 T 30-10-2018 IPR012902 Prokaryotic N-terminal methylation site pp2_030 4f48601c80a85e61871bcb163d5eee41 66 SUPERFAMILY SSF54523 6 37 1.49E-7 T 30-10-2018 pp2_030 4f48601c80a85e61871bcb163d5eee41 66 Gene3D G3DSA:3.30.700.10 6 63 9.3E-10 T 30-10-2018 pp2_030 4f48601c80a85e61871bcb163d5eee41 66 ProSitePatterns PS00409 Prokaryotic N-terminal methylation site. 4 24 - T 30-10-2018 IPR012902 Prokaryotic N-terminal methylation site pp2_030 4f48601c80a85e61871bcb163d5eee41 66 Pfam PF07963 Prokaryotic N-terminal methylation motif 2 24 7.9E-10 T 30-10-2018 IPR012902 Prokaryotic N-terminal methylation site pp2_003 11942ae4346fd0b67f7cbbbb52798e9b 97 Gene3D G3DSA:1.10.10.2850 20 92 8.9E-8 T 30-10-2018 pp2_003 11942ae4346fd0b67f7cbbbb52798e9b 97 Pfam PF16805 Phage late-transcription coactivator 24 93 3.8E-22 T 30-10-2018 IPR031836 Phage late-transcription coactivator pp2_360 84f2b961cf57fb5d82e75de666c2f9fb 163 PIRSF PIRSF004377 1 163 3.6E-55 T 30-10-2018 IPR016415 Bacteriophage T4, Gp68, prohead core pp2_344 909f1dc47421e6df183a87b85176f739 318 Pfam PF07880 Bacteriophage T4 gp9/10-like protein 3 307 3.6E-136 T 30-10-2018 IPR008987 Baseplate structural protein Gp9/Gp10 GO:0019076|GO:0098025 pp2_344 909f1dc47421e6df183a87b85176f739 318 SUPERFAMILY SSF50017 1 316 7.32E-72 T 30-10-2018 IPR036240 Gp9-like superfamily GO:0019076|GO:0098025 pp2_344 909f1dc47421e6df183a87b85176f739 318 Gene3D G3DSA:2.60.40.1680 202 316 4.0E-8 T 30-10-2018 IPR027412 Baseplate structural protein Gp9 C-terminal domain superfamily pp2_274 c5a19f9885af0acb7e300c5f7cc9fe73 223 SMART SM00507 5 51 1.9E-4 T 30-10-2018 IPR003615 HNH nuclease pp2_274 c5a19f9885af0acb7e300c5f7cc9fe73 223 Pfam PF01844 HNH endonuclease 21 43 1.3E-4 T 30-10-2018 IPR002711 HNH endonuclease GO:0003676|GO:0004519 pp2_069 53a1682b7dc37ec1b5299469c961583a 161 SUPERFAMILY SSF56784 13 155 3.03E-26 T 30-10-2018 IPR036412 HAD-like superfamily pp2_069 53a1682b7dc37ec1b5299469c961583a 161 Pfam PF06941 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C) 45 142 3.7E-9 T 30-10-2018 IPR010708 5'(3')-deoxyribonucleotidase GO:0008253|GO:0009264 Reactome: R-HSA-73621 pp2_069 53a1682b7dc37ec1b5299469c961583a 161 Gene3D G3DSA:3.40.50.1000 45 160 8.8E-29 T 30-10-2018 IPR023214 HAD superfamily pp2_330 1af774c908d614f251d27daad1173757 137 ProDom PD125086 DNA GP2 END PROTECTOR TERMINAL GP2-LIKE T4 ENDS PROTECTS PROTECTING 1 122 2.0E-35 T 30-10-2018 pp2_290 cc190415e3721524661297599e3b4e39 235 Pfam PF02562 PhoH-like protein 15 231 6.4E-67 T 30-10-2018 IPR003714 PhoH-like protein GO:0005524 pp2_290 cc190415e3721524661297599e3b4e39 235 Gene3D G3DSA:3.40.50.300 12 232 1.6E-56 T 30-10-2018 pp2_290 cc190415e3721524661297599e3b4e39 235 SUPERFAMILY SSF52540 16 178 7.72E-23 T 30-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase pp2_259 40086279fc03ed93ae4414a0f1f3e1c6 380 SUPERFAMILY SSF53756 47 325 1.48E-10 T 30-10-2018 pp2_270 78a68566243b89ea41efb45ce04ef86c 333 SUPERFAMILY SSF53756 3 321 2.35E-9 T 30-10-2018 pp2_289 f2310238a1e2ac3f6f6ae66cfe5c2857 161 SUPERFAMILY SSF55166 6 145 7.38E-13 T 30-10-2018 IPR009045 Hedgehog signalling/DD-peptidase zinc-binding domain superfamily Reactome: R-HSA-373080|Reactome: R-HSA-5358346|Reactome: R-HSA-5362798|Reactome: R-HSA-5632681|Reactome: R-HSA-5632684|Reactome: R-HSA-5635838|Reactome: R-HSA-5658034 pp2_008 803f9f89f71402eaa87c72c5bfd8f246 366 Gene3D G3DSA:3.40.50.300 27 350 1.1E-70 T 30-10-2018 pp2_008 803f9f89f71402eaa87c72c5bfd8f246 366 SUPERFAMILY SSF52540 30 277 1.38E-21 T 30-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase pp2_008 803f9f89f71402eaa87c72c5bfd8f246 366 Pfam PF00154 recA bacterial DNA recombination protein 49 276 2.6E-8 T 30-10-2018 IPR013765 DNA recombination and repair protein RecA GO:0003697|GO:0005524|GO:0006281 pp2_296 27b189039c6955a48d6411ba978f18ab 1109 Pfam PF13884 Chaperone of endosialidase 1000 1054 2.1E-16 T 30-10-2018 IPR030392 Intramolecular chaperone auto-processing domain pp2_340 cac8fdf3b0ef8458dd45744e5dbbce8e 139 Gene3D G3DSA:3.10.450.40 13 139 1.1E-38 T 30-10-2018 pp2_340 cac8fdf3b0ef8458dd45744e5dbbce8e 139 Pfam PF04965 Gene 25-like lysozyme 39 123 1.4E-15 T 30-10-2018 IPR007048 GpW/Gp25/anti-adapter protein IraD pp2_340 cac8fdf3b0ef8458dd45744e5dbbce8e 139 SUPERFAMILY SSF160719 34 124 1.1E-22 T 30-10-2018 pp2_253 a7c37e3b8d65877559d6805352e41ac9 227 Pfam PF06508 Queuosine biosynthesis protein QueC 76 173 1.6E-9 T 30-10-2018 IPR018317 Queuosine biosynthesis protein QueC KEGG: 00790+6.3.4.20|MetaCyc: PWY-6703 pp2_253 a7c37e3b8d65877559d6805352e41ac9 227 Gene3D G3DSA:3.40.50.620 6 180 2.0E-14 T 30-10-2018 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold pp2_253 a7c37e3b8d65877559d6805352e41ac9 227 SUPERFAMILY SSF52402 11 174 5.12E-12 T 30-10-2018 pp2_076 82be32de6e7ff6b4b04ec5d9e8e63c21 318 Gene3D G3DSA:3.40.50.300 2 159 2.5E-43 T 30-10-2018 pp2_076 82be32de6e7ff6b4b04ec5d9e8e63c21 318 Pfam PF00004 ATPase family associated with various cellular activities (AAA) 48 157 2.1E-14 T 30-10-2018 IPR003959 ATPase, AAA-type, core GO:0005524 pp2_076 82be32de6e7ff6b4b04ec5d9e8e63c21 318 Gene3D G3DSA:1.10.8.60 162 228 2.1E-24 T 30-10-2018 pp2_076 82be32de6e7ff6b4b04ec5d9e8e63c21 318 SMART SM00382 42 163 1.1E-5 T 30-10-2018 IPR003593 AAA+ ATPase domain pp2_076 82be32de6e7ff6b4b04ec5d9e8e63c21 318 SUPERFAMILY SSF52540 10 232 1.02E-31 T 30-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase pp2_076 82be32de6e7ff6b4b04ec5d9e8e63c21 318 Gene3D G3DSA:1.20.272.10 229 318 5.4E-34 T 30-10-2018 pp2_235 2458e492e91350f8ed26a150706e26ee 210 Gene3D G3DSA:2.60.120.620 6 201 1.0E-5 T 30-10-2018 pp2_021 ccfc02f60a5d567dc1817aa0dc3b5d12 165 Gene3D G3DSA:2.70.40.10 9 164 4.0E-43 T 30-10-2018 IPR036157 dUTPase-like superfamily pp2_021 ccfc02f60a5d567dc1817aa0dc3b5d12 165 SUPERFAMILY SSF51283 27 164 2.36E-35 T 30-10-2018 IPR036157 dUTPase-like superfamily pp2_021 ccfc02f60a5d567dc1817aa0dc3b5d12 165 Pfam PF00692 dUTPase 26 163 4.2E-26 T 30-10-2018 IPR029054 dUTPase-like pp2_021 ccfc02f60a5d567dc1817aa0dc3b5d12 165 TIGRFAM TIGR00576 dut: dUTP diphosphatase 27 163 3.1E-34 T 30-10-2018 IPR008181 Deoxyuridine triphosphate nucleotidohydrolase GO:0004170|GO:0046080 KEGG: 00240+3.6.1.23|KEGG: 00983+3.6.1.23 pp2_123 c61dc8ee35a4dfd8b9ad64114b443a02 202 Gene3D G3DSA:3.60.20.10 2 201 4.1E-10 T 30-10-2018 IPR029055 Nucleophile aminohydrolases, N-terminal pp2_123 c61dc8ee35a4dfd8b9ad64114b443a02 202 SUPERFAMILY SSF56235 1 169 1.64E-10 T 30-10-2018 IPR029055 Nucleophile aminohydrolases, N-terminal pp2_294 272135810d83fa03c7d99032c61e0012 98 Pfam PF11195 Protein of unknown function (DUF2829) 2 95 1.8E-26 T 30-10-2018 IPR021361 Protein of unknown function DUF2829 pp2_341 4d619496474677c8a9588e4ab9ecf3a6 652 Hamap MF_04102 Baseplate wedge protein gp6. 1 652 42.613 T 30-10-2018 IPR034698 Baseplate wedge protein gp6 GO:0098025 pp2_341 4d619496474677c8a9588e4ab9ecf3a6 652 Gene3D G3DSA:3.30.300.200 331 407 6.9E-39 T 30-10-2018 pp2_090 651dd702065181e921028ecc8f87c746 170 Pfam PF01661 Macro domain 32 147 5.6E-7 T 30-10-2018 IPR002589 Macro domain pp2_090 651dd702065181e921028ecc8f87c746 170 SUPERFAMILY SSF52949 3 163 1.14E-30 T 30-10-2018 pp2_090 651dd702065181e921028ecc8f87c746 170 SMART SM00506 2 148 0.0073 T 30-10-2018 IPR002589 Macro domain pp2_090 651dd702065181e921028ecc8f87c746 170 Gene3D G3DSA:3.40.220.10 3 169 4.6E-26 T 30-10-2018 pp2_016 735298d9306f3f808e2f62a33d1e59c6 174 Gene3D G3DSA:3.60.21.10 2 167 6.0E-29 T 30-10-2018 IPR029052 Metallo-dependent phosphatase-like pp2_016 735298d9306f3f808e2f62a33d1e59c6 174 SUPERFAMILY SSF56300 1 140 3.56E-13 T 30-10-2018 pp2_148 da6a300122046bf671074a1b1f55c384 346 Pfam PF10127 Predicted nucleotidyltransferase 2 130 2.5E-6 T 30-10-2018 IPR018775 Nucleotidyltransferase, predicted pp2_060 f9dfa4b78ab2c4d30c88ad1d3553ebbc 79 Gene3D G3DSA:3.40.30.10 1 74 1.9E-9 T 30-10-2018 pp2_060 f9dfa4b78ab2c4d30c88ad1d3553ebbc 79 SUPERFAMILY SSF52833 2 76 2.87E-12 T 30-10-2018 IPR036249 Thioredoxin-like superfamily pp2_188 7e0cd4a4fa519029d102ca195c4feff3 194 Pfam PF00265 Thymidine kinase 3 185 4.5E-36 T 30-10-2018 IPR001267 Thymidine kinase GO:0004797|GO:0005524 KEGG: 00240+2.7.1.21|KEGG: 00983+2.7.1.21|MetaCyc: PWY-7199|Reactome: R-HSA-539107|Reactome: R-HSA-73614 pp2_188 7e0cd4a4fa519029d102ca195c4feff3 194 SUPERFAMILY SSF52540 1 139 3.65E-32 T 30-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase pp2_188 7e0cd4a4fa519029d102ca195c4feff3 194 Gene3D G3DSA:3.40.50.300 1 139 1.2E-22 T 30-10-2018 pp2_188 7e0cd4a4fa519029d102ca195c4feff3 194 PIRSF PIRSF035805 1 194 3.5E-52 T 30-10-2018 IPR001267 Thymidine kinase GO:0004797|GO:0005524 KEGG: 00240+2.7.1.21|KEGG: 00983+2.7.1.21|MetaCyc: PWY-7199|Reactome: R-HSA-539107|Reactome: R-HSA-73614 pp2_188 7e0cd4a4fa519029d102ca195c4feff3 194 SUPERFAMILY SSF57716 142 188 8.55E-5 T 30-10-2018 pp2_188 7e0cd4a4fa519029d102ca195c4feff3 194 Hamap MF_00124 Thymidine kinase [tdk]. 1 188 27.649 T 30-10-2018 IPR001267 Thymidine kinase GO:0004797|GO:0005524 KEGG: 00240+2.7.1.21|KEGG: 00983+2.7.1.21|MetaCyc: PWY-7199|Reactome: R-HSA-539107|Reactome: R-HSA-73614 pp2_322 8e151f698294896995edc0bf539ba578 151 SUPERFAMILY SSF55144 13 123 2.22E-9 T 30-10-2018 IPR009097 Cyclic phosphodiesterase pp2_322 8e151f698294896995edc0bf539ba578 151 Gene3D G3DSA:3.90.1140.10 12 149 1.3E-5 T 30-10-2018 pp2_074 8fa56c1b2e2c0934e91c69ddfe59432a 69 Pfam PF17470 Phage protein Gp45.2 5 61 1.6E-37 T 30-10-2018 IPR035342 Phage protein Gp45.2 pp2_298 d13f8c32623edf22a86da58b8ada891b 174 Pfam PF04308 Ribonuclease H-like 7 143 9.9E-17 T 30-10-2018 IPR007405 Bacteriophage KVP40, Orf299 pp2_379 4e7e6b83b87884c11d3b265bbee1ae5c 57 Pfam PF08410 Domain of unknown function (DUF1737) 19 42 2.2E-5 T 30-10-2018 IPR013619 Domain of unknown function DUF1737 pp2_028 dc6a1200dd58981b045921daa5547aa6 147 Gene3D G3DSA:3.40.1490.10 11 105 1.4E-5 T 30-10-2018 IPR023476 Peptidyl-tRNA hydrolase II domain superfamily MetaCyc: PWY-6308 pp2_028 dc6a1200dd58981b045921daa5547aa6 147 Pfam PF01981 Peptidyl-tRNA hydrolase PTH2 19 72 1.9E-4 T 30-10-2018 IPR002833 Peptidyl-tRNA hydrolase, PTH2 GO:0004045 MetaCyc: PWY-6308 pp2_363 4314250e70c177fd2e1370de27e8f14b 514 Hamap MF_04117 Major capsid protein. 1 514 55.501 T 30-10-2018 IPR038997 Major capsid protein, Myoviridae GO:0019028 pp2_363 4314250e70c177fd2e1370de27e8f14b 514 Pfam PF07068 Major capsid protein Gp23 3 495 0.0 T 30-10-2018 IPR010762 Capsid protein, T4-like bacteriophage-like GO:0019012|GO:0019028 pp2_244 ae5c913d5cf6ce9cb448a6cc9be1798e 109 Pfam PF11750 Protein of unknown function (DUF3307) 7 105 2.7E-8 T 30-10-2018 IPR021737 Bacteriophage phiKZ, Orf197 pp2_255 72a4807d4021eb6d9fd0a72b97b1e57c 329 Pfam PF13353 4Fe-4S single cluster domain 89 199 1.3E-4 T 30-10-2018 pp2_255 72a4807d4021eb6d9fd0a72b97b1e57c 329 SUPERFAMILY SSF102114 84 253 5.76E-14 T 30-10-2018 pp2_255 72a4807d4021eb6d9fd0a72b97b1e57c 329 Gene3D G3DSA:3.20.20.70 76 314 4.6E-17 T 30-10-2018 IPR013785 Aldolase-type TIM barrel GO:0003824 pp2_297 7056d0f4ab9c47a2bc014cd4f7d54e9b 1091 Pfam PF03903 Phage T4 tail fibre 1 61 4.4E-8 T 30-10-2018 IPR005601 Tail fibre protein p36 pp2_297 7056d0f4ab9c47a2bc014cd4f7d54e9b 1091 Pfam PF13884 Chaperone of endosialidase 991 1041 8.5E-13 T 30-10-2018 IPR030392 Intramolecular chaperone auto-processing domain pp2_023 e5548697919a19359d8ce9607d76452c 230 Pfam PF16473 3' exoribonuclease, RNase T-like 9 192 2.1E-17 T 30-10-2018 IPR033390 3'-5' exoribonuclease Rv2179c-like domain pp2_023 e5548697919a19359d8ce9607d76452c 230 SUPERFAMILY SSF53098 5 201 5.64E-8 T 30-10-2018 IPR012337 Ribonuclease H-like superfamily pp2_331 78670442c1c5b91980f7fa2dfb1be0bf 151 Pfam PF08722 TnsA endonuclease N terminal 60 140 4.0E-6 T 30-10-2018 IPR014833 TnsA endonuclease, N-terminal pp2_010 0e1e7acb33bd1dc1680f98cf63bb5801 427 Pfam PF03796 DnaB-like helicase C terminal domain 139 392 1.3E-19 T 30-10-2018 IPR007694 DNA helicase, DnaB-like, C-terminal GO:0003678|GO:0005524|GO:0006260 Reactome: R-HSA-2151201 pp2_010 0e1e7acb33bd1dc1680f98cf63bb5801 427 Gene3D G3DSA:3.40.50.300 113 403 2.2E-40 T 30-10-2018 pp2_010 0e1e7acb33bd1dc1680f98cf63bb5801 427 SUPERFAMILY SSF52540 136 387 2.16E-24 T 30-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase pp2_351 27bf43ac55a440e7ae69dd442985290f 278 Pfam PF11649 Virus neck protein 1 278 3.1E-177 T 30-10-2018 IPR021674 Bacteriophage T4, Gp14, neck protein pp2_034 8ee268d477003a9be4a32f8e8c3ecff7 106 SUPERFAMILY SSF101386 12 98 3.66E-6 T 30-10-2018 pp2_034 8ee268d477003a9be4a32f8e8c3ecff7 106 Gene3D G3DSA:1.10.287.1080 2 106 3.2E-5 T 30-10-2018 pp2_325 41dbc3226f0121a36d0846fdfd7f6b3d 177 Pfam PF06841 T4-like virus tail tube protein gp19 8 160 1.6E-10 T 30-10-2018 IPR010667 Bacteriophage T4, Gp19, tail tube GO:0005198 pp2_009 ed701f48a5d96d8c26d7c99a2453df33 100 Pfam PF11113 Head assembly gene product 28 64 4.9E-7 T 30-10-2018 IPR021049 Bacteriophage T4, Gp40, head assembly pp2_381 0c9d100e32b316dc36ed1686fc07ba68 137 Pfam PF11056 Recombination, repair and ssDNA binding protein UvsY 9 135 7.2E-48 T 30-10-2018 IPR021289 Recombination, repair and ssDNA binding protein UvsY pp2_120 e05e2be2e5c934cba3647dc66c8f3b28 458 Gene3D G3DSA:3.20.20.105 9 251 1.7E-5 T 30-10-2018 IPR036511 Queuine tRNA-ribosyltransferase-like GO:0006400|GO:0016763 MetaCyc: PWY-6700|Reactome: R-HSA-6782315 pp2_058 f9687eea1742f158d8b7e0e9d7518fb7 167 Pfam PF17527 Phage ALP protein 1 164 7.2E-76 T 30-10-2018 IPR020367 Host transcription inhibitor Alc GO:0039653 pp2_019 27faa887dab64fce5d7d0ea20717020d 158 Pfam PF07068 Major capsid protein Gp23 107 142 9.0E-5 T 30-10-2018 IPR010762 Capsid protein, T4-like bacteriophage-like GO:0019012|GO:0019028