locus-tag class description C5Q97_00030 ENOG4105WBN Transcriptional regulator (LacI family C5Q97_00040 ENOG4105CNT hydrolase family 2 C5Q97_00050 ENOG4105ETE Transcriptional regulator (LacI family C5Q97_00060 ENOG4108SU4 UPF0309 protein C5Q97_00115 ENOG4108UW5 maltose o-acetyltransferase C5Q97_00135 ENOG4105ETE Transcriptional regulator (LacI family C5Q97_00165 ENOG4105CNA YD repeat protein C5Q97_00170 ENOG4105CNA YD repeat protein C5Q97_00195 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) C5Q97_00200 ENOG4105EY8 ABC transporter C5Q97_00215 ENOG4108YRB methyltransferase C5Q97_00225 ENOG4107EF8 Glycosyl transferase (Group 1 C5Q97_00230 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase C5Q97_00355 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) C5Q97_00365 ENOG4105C3U ABC transporter C5Q97_00370 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) C5Q97_00375 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) C5Q97_00395 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) C5Q97_00400 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) C5Q97_00415 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate C5Q97_00420 ENOG4105DZS Phenylacetate-CoA ligase C5Q97_00425 ENOG4106MP8 UPF0754 membrane protein C5Q97_00470 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic C5Q97_00485 ENOG4105EF1 ribulokinase C5Q97_00495 ENOG4105CAC Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) C5Q97_00500 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) C5Q97_00505 ENOG4105DMW Dehydrogenase reductase C5Q97_00525 ENOG4108QXE glycerophosphoryl diester phosphodiesterase C5Q97_00530 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase C5Q97_00535 ENOG4105ETE Transcriptional regulator (LacI family C5Q97_00540 ENOG4105C0P Mg chelatase subunit ChlI C5Q97_00550 ENOG4106H78 methyltransferase C5Q97_00555 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) C5Q97_00565 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) C5Q97_00575 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) C5Q97_00580 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component C5Q97_00605 ENOG4105CJ1 ABC, transporter C5Q97_00625 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) C5Q97_00630 ENOG4105CNT hydrolase family 2 C5Q97_00635 ENOG4105CDA abc transporter atp-binding protein C5Q97_00640 ENOG4105E5Q amino acid AbC transporter C5Q97_00645 ENOG4108HW3 (ABC) transporter C5Q97_00660 ENOG4107EXU Short-chain dehydrogenase reductase Sdr C5Q97_00665 ENOG4105NA0 Transcriptional regulator C5Q97_00700 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) C5Q97_00730 ENOG410902H NADH dehydrogenase (Ubiquinone), 24 kDa subunit C5Q97_00735 ENOG4107QIZ NADH dehydrogenase C5Q97_00740 ENOG4107QHI -hydrogenase C5Q97_00775 ENOG4105EDR glucose galactose transporter C5Q97_00800 ENOG4105CHR reductase C5Q97_00820 ENOG4108VAU general secretion pathway protein G C5Q97_00830 ENOG4105ETE Transcriptional regulator (LacI family C5Q97_00850 ENOG4105ETE Transcriptional regulator (LacI family C5Q97_00860 ENOG4105ETE Transcriptional regulator (LacI family C5Q97_00880 ENOG4105ETE Transcriptional regulator (LacI family C5Q97_00885 ENOG4108UN4 phage SPO1 DNA polymerase-related protein C5Q97_00895 ENOG4105CDH Citrulline--aspartate ligase C5Q97_00900 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) C5Q97_00910 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) C5Q97_00915 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) C5Q97_00920 ENOG4105C0A alcohol dehydrogenase C5Q97_00955 ENOG4105ETE Transcriptional regulator (LacI family C5Q97_01015 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) C5Q97_01020 ENOG4105CK5 oxidoreductase C5Q97_01025 ENOG4108IAJ Nad-dependent epimerase dehydratase C5Q97_01055 ENOG4105EAM Na Pi-cotransporter C5Q97_01065 ENOG4107GFK fumarate C5Q97_01085 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) C5Q97_01110 ENOG4105ETE Transcriptional regulator (LacI family C5Q97_01115 ENOG4105C2M dna polymerase I C5Q97_01230 ENOG4105F8D glycoside hydrolase family 4 C5Q97_01255 ENOG4105I82 acetyl xylan esterase C5Q97_01275 ENOG4105ETE Transcriptional regulator (LacI family C5Q97_01340 ENOG4105RHY Pfam:UPF0157 C5Q97_01350 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) C5Q97_01370 ENOG4105CK6 Two component transcriptional regulator (Winged helix family C5Q97_01375 ENOG4107QV7 Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) C5Q97_01380 ENOG4107QQG Dehydrogenase C5Q97_01385 ENOG4108IAJ Nad-dependent epimerase dehydratase C5Q97_01395 ENOG4108JU4 Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto- arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4- amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido- arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) C5Q97_01400 ENOG4105C6Y Udp-glucose 6-dehydrogenase C5Q97_01410 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) C5Q97_01415 ENOG4105EGS Mechanosensitive ion channel C5Q97_01430 ENOG4105ETE Transcriptional regulator (LacI family C5Q97_01440 ENOG4105CTM Glycoside hydrolase family 5 C5Q97_01470 ENOG4105C7K acetolactate synthase C5Q97_01480 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase C5Q97_01500 ENOG4105ETE Transcriptional regulator (LacI family C5Q97_01515 ENOG4105CKB glycosidase C5Q97_01535 ENOG4105ETE Transcriptional regulator (LacI family C5Q97_01545 ENOG4105C6T cysteine synthase C5Q97_01550 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) C5Q97_01565 ENOG4108MIW Induces the synthesis of acid phosphatase (AppA) and several other polypeptides (such as AppBC) during the deceleration phase of growth. It also acts as a transcriptional repressor for one group of proteins that are synthesized preferentially in exponential growth and for one group synthesized only in the stationary phase. Also involved in the stabilization of the sigma stress factor RpoS during stress conditions C5Q97_01575 ENOG4105D1F ATP-binding protein C5Q97_01585 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA C5Q97_01590 ENOG4108IUZ ABC transporter C5Q97_01600 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase C5Q97_01605 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase C5Q97_01610 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) C5Q97_01615 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) C5Q97_01640 ENOG4105CX6 glutaminyL-tRNA synthetase C5Q97_01645 ENOG4107S2Z UPF0761 membrane protein C5Q97_01735 ENOG4105C0D helicase C5Q97_01780 ENOG4105MZU cell filamentation protein C5Q97_01790 ENOG4105ECQ AraC Family Transcriptional Regulator C5Q97_01830 ENOG4105KST dependent repressor C5Q97_01835 ENOG4105CE1 Ferrous iron transport protein b C5Q97_01905 ENOG4105CS2 ec 3.2.1.21 C5Q97_02100 ENOG4108KU3 Integrase C5Q97_02110 ENOG4108J1Q C5Q97_02160 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) C5Q97_02175 ENOG4105D1H recombination factor protein RarA C5Q97_02185 ENOG4105C1J atp-dependent rna helicase C5Q97_02190 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein C5Q97_02205 ENOG4105EZY Pyrroloquinoline quinone biosynthesis protein E C5Q97_02245 ENOG4106855 Competence protein C5Q97_02330 ENOG41089S2 PQQ-dependent dehydrogenase, methanol ethanol family C5Q97_02335 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase C5Q97_02355 ENOG4105S10 periplasmic binding protein C5Q97_02370 ENOG4108R96 Methyltransferase, YaeB family C5Q97_02385 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) C5Q97_02420 ENOG4108UPT UPF0178 protein C5Q97_02440 ENOG4105MAX Superoxide reductase C5Q97_02480 ENOG4105DTA methyltransferase C5Q97_02490 ENOG4105CHH sulfate transporter C5Q97_02500 ENOG4105CEN a g-specific adenine glycosylase C5Q97_02505 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) C5Q97_02515 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit C5Q97_02520 ENOG4105ETE Transcriptional regulator (LacI family C5Q97_02555 ENOG4105CPC Aldo Keto reductase C5Q97_02570 ENOG4105DIJ Phosphoethanolamine transferase C5Q97_02585 ENOG4105CKB glycosidase C5Q97_02610 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) C5Q97_02630 ENOG4108UGV hypoxanthine phosphoribosyltransferase C5Q97_02640 ENOG4108UVJ appr-1-p processing domain protein C5Q97_02655 ENOG41082DI 50s ribosomal protein l31 C5Q97_02660 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) C5Q97_02680 ENOG4105QNF Outer membrane lipoprotein C5Q97_02695 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) C5Q97_02700 ENOG4105BZU Histidine kinase C5Q97_02725 ENOG4105HY2 Glycosidase related protein C5Q97_02755 ENOG410904A RNA polymerase C5Q97_02780 ENOG4105D16 lipopolysaccharide heptosyltransferase i C5Q97_02810 ENOG4105C0H protease C5Q97_02815 ENOG4105CN1 protease C5Q97_02820 ENOG4105CG3 alpha amylase, catalytic region C5Q97_02835 ENOG4107QI1 Mate efflux family protein C5Q97_02840 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) C5Q97_02860 ENOG4108N16 Negative regulator of allantoin and glyoxylate utilization operons. Binds to the gcl promoter and to the allS- allA intergenic region C5Q97_02870 ENOG4108RTU Aldolase C5Q97_02905 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) C5Q97_02910 ENOG4105C34 Pseudouridine synthase C5Q97_02925 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) C5Q97_02980 ENOG4107WDG serine threonine protein kinase C5Q97_03035 ENOG4105DZR Type I site-specific deoxyribonuclease C5Q97_03070 ENOG4108HFV C5Q97_03150 ENOG4108J1Q C5Q97_03155 ENOG4108RS6 transposase C5Q97_03250 ENOG4108VAU general secretion pathway protein G C5Q97_03260 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase C5Q97_03280 ENOG4105BZU Histidine kinase C5Q97_03310 ENOG4105GVR general secretion pathway protein D C5Q97_03315 ENOG4107QHF type ii secretion system protein e C5Q97_03320 ENOG4105D7Q type ii secretion system C5Q97_03325 ENOG4108VAU general secretion pathway protein G C5Q97_03340 ENOG4108WWZ General secretion pathway protein J C5Q97_03370 ENOG4105CTM Glycoside hydrolase family 5 C5Q97_03380 ENOG4105ETE Transcriptional regulator (LacI family C5Q97_03425 ENOG4105ETE Transcriptional regulator (LacI family C5Q97_03445 ENOG4105CT4 transporter C5Q97_03455 ENOG4108UJD 30S ribosomal protein S9 C5Q97_03460 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) C5Q97_03465 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) C5Q97_03485 ENOG4108BRW Activates expression of the rhaSR operon in response to L-rhamnose (By similarity) C5Q97_03520 ENOG4105KPY Small multidrug resistance protein C5Q97_03525 ENOG4105CT7 inner membrane cred family protein C5Q97_03530 ENOG4105D3Q Sugar transferase C5Q97_03545 ENOG41080E8 Transcriptional regulator, Spx MgsR family C5Q97_03550 ENOG4108428 Inherit from COG: -acetyltransferase C5Q97_03570 ENOG4107QVM von Willebrand factor, type A C5Q97_03580 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR C5Q97_03595 ENOG4105ETE Transcriptional regulator (LacI family C5Q97_03610 ENOG4105I82 acetyl xylan esterase C5Q97_03635 ENOG4105CV8 reductase C5Q97_03640 ENOG4105ETE Transcriptional regulator (LacI family C5Q97_03665 ENOG4107YHV Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) C5Q97_03670 ENOG4105DIN metallophosphoesterase C5Q97_03690 ENOG4107ZFB This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) C5Q97_03695 ENOG4105CZX twitching motility protein C5Q97_03705 ENOG4107STF Involved in phosphonate degradation (By similarity) C5Q97_03735 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) C5Q97_03765 ENOG4105CMD Transcriptional regulator, GntR family C5Q97_03805 ENOG4105D9R oxidoreductase C5Q97_03810 ENOG4105EE1 crotonyl-CoA reductase C5Q97_03820 ENOG4105CHR reductase C5Q97_03850 ENOG4105ETE Transcriptional regulator (LacI family C5Q97_03855 ENOG4105EHZ conserved protein UCP016719 C5Q97_03875 ENOG41060NJ transcriptional regulator C5Q97_03880 ENOG4105BZU Histidine kinase C5Q97_03885 ENOG4108UT2 hemolysin iii C5Q97_03895 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) C5Q97_03900 ENOG4105C9X ppx gppa phosphatase C5Q97_03910 ENOG4105E2X shikimate dehydrogenase C5Q97_03920 ENOG4105DKG l-rhamnose isomerase C5Q97_03925 ENOG4107QMF Sorbitol-6-phosphate dehydrogenase C5Q97_03935 ENOG4105EUJ GTP cyclohydrolase i C5Q97_03940 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) C5Q97_03945 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) C5Q97_03955 ENOG4105DZP Membrane-associated zinc metalloprotease C5Q97_03960 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) C5Q97_03970 ENOG4105DFY n-acylglucosamine 2-epimerase C5Q97_03980 ENOG4108V6E Cell division protein mraZ C5Q97_04020 ENOG4105CHJ isochorismatase hydrolase C5Q97_04030 ENOG4105BZU Histidine kinase C5Q97_04035 ENOG4105CK6 Two component transcriptional regulator (Winged helix family C5Q97_04040 ENOG4105C8N cysteinyl-tRNA synthetase C5Q97_04190 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP C5Q97_04240 ENOG4105CFI type iii restriction protein res subunit C5Q97_04295 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) C5Q97_04300 ENOG4105NI8 Cytosine-specific methyltransferase C5Q97_04525 ENOG41090BB DNA mismatch endonuclease (vsr) C5Q97_04585 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) C5Q97_04630 ENOG4105E09 nadh pyrophosphatase C5Q97_04655 ENOG4105KT5 UmuD protein C5Q97_04660 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) C5Q97_04760 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) C5Q97_04770 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) C5Q97_04810 ENOG4107QUV Domain protein C5Q97_04850 ENOG4105UFH BadM Rrf2 family transcriptional regulator C5Q97_04865 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) C5Q97_04875 ENOG4105C3S Mate efflux family protein C5Q97_04895 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) C5Q97_04910 ENOG4107QSA Oxaloacetate decarboxylase C5Q97_04920 ENOG410631K Membrane C5Q97_04950 ENOG4106855 Competence protein C5Q97_04960 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) C5Q97_04965 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) C5Q97_04970 ENOG4108JCI Transcriptional regulator C5Q97_04985 ENOG4105E7U AraC family transcriptional regulator C5Q97_04990 ENOG4105ETE Transcriptional regulator (LacI family C5Q97_05090 ENOG4105CJ1 ABC, transporter C5Q97_05100 ENOG4105C7R Atpase associated with various cellular activities aaa_3 C5Q97_05125 ENOG4105CI3 gtp-binding protein typa C5Q97_05170 ENOG4105PAD Hydrolase C5Q97_05200 ENOG4105C5H ABC transporter C5Q97_05210 ENOG4105EZY Pyrroloquinoline quinone biosynthesis protein E C5Q97_05215 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) C5Q97_05225 ENOG4107T5V SNARE associated Golgi C5Q97_05240 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) C5Q97_05260 ENOG4108J1Q C5Q97_05315 ENOG4105EQK -acetyltransferase C5Q97_05340 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase C5Q97_05345 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) C5Q97_05430 ENOG4105D4U had-superfamily hydrolase, subfamily iia C5Q97_05440 ENOG4108JU3 Alkyl hydroperoxide reductase C5Q97_05450 ENOG4108QXE glycerophosphoryl diester phosphodiesterase C5Q97_05455 ENOG4107RH8 nuclease SbcCD subunit D C5Q97_05460 ENOG4105EYH Exonuclease C5Q97_05465 ENOG4105C8I hydrolase, family 38 C5Q97_05475 ENOG4108Z6B deaminase C5Q97_05485 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) C5Q97_05495 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) C5Q97_05500 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) C5Q97_05565 ENOG4108CIP transcriptional regulator C5Q97_05570 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) C5Q97_05575 ENOG4105CMD Transcriptional regulator, GntR family C5Q97_05605 ENOG4105DDI hemolysin-type calcium-binding region C5Q97_05625 ENOG41069M3 Transcriptional regulator C5Q97_05630 ENOG4105C6N Formate acetyltransferase C5Q97_05635 ENOG4105C6N Formate acetyltransferase C5Q97_05640 ENOG4105C6N Formate acetyltransferase C5Q97_05640 ENOG4105C6N Formate acetyltransferase C5Q97_05645 ENOG4105C0A alcohol dehydrogenase C5Q97_05660 ENOG4105ECY inositol monophosphatase C5Q97_05675 ENOG4105FDP GntR family transcriptional regulator C5Q97_05710 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) C5Q97_05715 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) C5Q97_05735 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) C5Q97_05745 ENOG4108RG7 formate hydrogenlyase complex iron-sulfur subunit C5Q97_05750 ENOG4105C8J )-transporter C5Q97_05755 ENOG4105CK5 oxidoreductase C5Q97_05775 ENOG4105CCT upf0313 protein C5Q97_05785 ENOG4105CTQ phosphohexokinase C5Q97_05815 ENOG4105ETE Transcriptional regulator (LacI family C5Q97_05835 ENOG4105C79 DNA protecting protein DprA C5Q97_05855 ENOG4105WMR Protein CrcB homolog C5Q97_05875 ENOG4105KK6 nuclease C5Q97_05885 ENOG4105BZ1 (ABC) transporter C5Q97_05890 ENOG4108JJA ABC, transporter C5Q97_05920 ENOG4105C4X radical SAM domain protein C5Q97_05940 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) C5Q97_05960 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) C5Q97_05970 ENOG4105CC5 ABC transporter C5Q97_05975 ENOG4105FDK ABC transporter C5Q97_05980 ENOG4105DSE periplasmic solute binding protein C5Q97_06015 ENOG4105K59 histidine triad (HIT) protein C5Q97_06020 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase C5Q97_06040 ENOG4105C2X Arabinose 5-phosphate isomerase C5Q97_06045 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) C5Q97_06050 ENOG4105M0N phosphoribosyl-ATP pyrophosphatase C5Q97_06060 ENOG4108UB4 uncharacterized protein ygjQ C5Q97_06075 ENOG4108VAU general secretion pathway protein G C5Q97_06120 ENOG4105C0B DNA polymerase III (alpha subunit) C5Q97_06140 ENOG4105EY8 ABC transporter C5Q97_06170 ENOG4105DDV Transcriptional regulator (LacI family C5Q97_06190 ENOG4105F2F Xylan 1,4-beta-xylosidase (EC 3.2.1.37) C5Q97_06215 ENOG4105DRS transport system, permease C5Q97_06235 ENOG4107QZW Altronate oxidoreductase C5Q97_06240 ENOG4105CTX dehydratase C5Q97_06250 ENOG410872P Binds directly to 16S ribosomal RNA (By similarity) C5Q97_06260 ENOG4105ETE Transcriptional regulator (LacI family C5Q97_06265 ENOG4105CMR udp-glucose 4-epimerase C5Q97_06270 ENOG4108JDX DNA polymerase iii, epsilon subunit C5Q97_06280 ENOG4105K64 Glycosyl transferase, family 2 C5Q97_06320 ENOG4106HBX Transcriptional Regulator AraC Family C5Q97_06335 ENOG4105DSY exodeoxyribonuclease V, gamma C5Q97_06340 ENOG4107QKA exodeoxyribonuclease V beta C5Q97_06345 ENOG4107QYX exodeoxyribonuclease v alpha C5Q97_06365 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) C5Q97_06370 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) C5Q97_06390 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) C5Q97_06420 ENOG4106R7G Glycoside hydrolase family 5 C5Q97_06455 ENOG4105W2C Glycosyl transferase C5Q97_06495 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein C5Q97_06510 ENOG4105D7W serine acetyltransferase C5Q97_06525 ENOG4105PSV Polysaccharide Biosynthesis Protein C5Q97_06530 ENOG4105C30 Nad-dependent epimerase dehydratase C5Q97_06535 ENOG4105C0K Gdp-mannose 4,6-dehydratase C5Q97_06565 ENOG4107WCA isomerase C5Q97_06580 ENOG4105CPF Cell wall formation (By similarity) C5Q97_06585 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase C5Q97_06595 ENOG4105C5I Dehydrogenase C5Q97_06605 ENOG4106AM8 polysaccharide lyase family 8 C5Q97_06630 ENOG4105CH7 arginosuccinase C5Q97_06635 ENOG4105CE9 30S ribosomal protein S2 C5Q97_06640 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) C5Q97_06680 ENOG4105C9U ATP-dependent DNA helicase RecQ C5Q97_06710 ENOG4108UW5 maltose o-acetyltransferase C5Q97_06720 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) C5Q97_06735 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) C5Q97_06755 ENOG4105XA0 heptosyltransferase ii C5Q97_06760 ENOG4105DFF Rod shape-determining protein mreb C5Q97_06785 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) C5Q97_06795 ENOG4108I5C dEAD DEAH box helicase C5Q97_06830 ENOG4108VAU general secretion pathway protein G C5Q97_06865 ENOG4105CE4 GlcNAc 6-P deacetylase C5Q97_06890 ENOG4105FDP GntR family transcriptional regulator C5Q97_06905 ENOG4105C08 Histidine kinase C5Q97_06910 ENOG4105BZU Histidine kinase C5Q97_06915 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family C5Q97_06925 ENOG4105NI8 Cytosine-specific methyltransferase C5Q97_07185 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) C5Q97_07190 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase C5Q97_07195 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) C5Q97_07200 ENOG4105DC7 peptidase M24 C5Q97_07205 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) C5Q97_07210 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase C5Q97_07215 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase C5Q97_07220 ENOG4105C99 atpase involved in dna repair C5Q97_07225 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) C5Q97_07235 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase C5Q97_07245 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) C5Q97_07265 ENOG4105CK5 oxidoreductase C5Q97_07300 ENOG4105VFU Rna-binding protein C5Q97_07310 ENOG41074MP UPF0103 Mediator of ErbB2-driven cell motility-containing protein C5Q97_07315 ENOG4105CQC Prephenate dehydratase C5Q97_07325 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) C5Q97_07330 ENOG4105DR4 Methyltransferase C5Q97_07365 ENOG4105CF7 AraC family transcriptional regulator C5Q97_07380 ENOG4105CXN decarboxylase C5Q97_07385 ENOG4105E5D amino acid C5Q97_07400 ENOG4105KT7 mgtC SapB transporter C5Q97_07410 ENOG4108JUA Transcriptional regulator C5Q97_07415 ENOG4105CHM Aminotransferase C5Q97_07425 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) C5Q97_07430 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) C5Q97_07435 ENOG4105CFG Acts as a chaperone (By similarity) C5Q97_07450 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) C5Q97_07465 ENOG4105EMU Dehydrogenase C5Q97_07470 ENOG4107QN2 dihydrolipoyl dehydrogenase C5Q97_07475 ENOG4105ID8 Transcriptional regulator, ARAC family C5Q97_07480 ENOG4105CQ7 ATP-dependent helicase C5Q97_07515 ENOG4105CXK mandelate racemase muconate lactonizing C5Q97_07520 ENOG4105CHR reductase C5Q97_07545 ENOG41075H3 AraC family transcriptional regulator C5Q97_07560 ENOG4108IA2 Sodium pantothenate symporter C5Q97_07565 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) C5Q97_07585 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) C5Q97_07590 ENOG4105CZX twitching motility protein C5Q97_07615 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) C5Q97_07625 ENOG4108JQ7 (ABC) transporter C5Q97_07635 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component C5Q97_07660 ENOG4108TZY GntR Family Transcriptional Regulator C5Q97_07685 ENOG4105ETE Transcriptional regulator (LacI family C5Q97_07695 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component C5Q97_07700 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component C5Q97_07720 ENOG4107QWR cellulase (EC 3.2.1.4) C5Q97_07760 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase C5Q97_07770 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) C5Q97_07775 ENOG4105D9Q decarboxylase (Beta subunit) C5Q97_07790 ENOG4105CBX hi0933 family C5Q97_07815 ENOG4108VAU general secretion pathway protein G C5Q97_07830 ENOG4105QUH Domain of unknown function (DUF2088) C5Q97_07835 ENOG4105BZJ Electron transfer flavoprotein C5Q97_07840 ENOG4105C10 Electron transfer flavoprotein C5Q97_07845 ENOG4105CQB FAD linked oxidase domain protein C5Q97_07855 ENOG4105FTV AraC Family Transcriptional Regulator C5Q97_07860 ENOG4108IUK alpha amylase, catalytic C5Q97_07870 ENOG4105KQ5 peptidylprolyl cis-trans isomerase C5Q97_07885 ENOG4105CNT hydrolase family 2 C5Q97_07890 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) C5Q97_07905 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) C5Q97_07920 ENOG4105CX8 fg-gap repeat protein C5Q97_07925 ENOG4105FKQ transcriptional regulator C5Q97_07935 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) C5Q97_07940 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) C5Q97_07950 ENOG4105CQ4 Transcriptional regulator C5Q97_07970 ENOG4105CPN adenine deaminase C5Q97_07975 ENOG4105WPN DNA integration recombination invertion protein C5Q97_07990 ENOG4105CFP Peptidase U32 C5Q97_07995 ENOG4105C7R Atpase associated with various cellular activities aaa_3 C5Q97_08005 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) C5Q97_08050 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii C5Q97_08075 ENOG4108UHU Aldolase C5Q97_08095 ENOG4105DZS Phenylacetate-CoA ligase C5Q97_08140 ENOG4105UQX Mate efflux family protein C5Q97_08165 ENOG4105DDV Transcriptional regulator (LacI family C5Q97_08195 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I C5Q97_08200 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) C5Q97_08205 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) C5Q97_08215 ENOG4105C3G gtp-binding protein C5Q97_08225 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) C5Q97_08230 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) C5Q97_08250 ENOG4105ETE Transcriptional regulator (LacI family C5Q97_08295 ENOG4105ETE Transcriptional regulator (LacI family C5Q97_08335 ENOG4105CJ2 (LipO)protein C5Q97_08340 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) C5Q97_08345 ENOG4105CK7 Sodium proline symporter C5Q97_08355 ENOG410851C 50S ribosomal protein l28 C5Q97_08370 ENOG4108J9M Transporter C5Q97_08380 ENOG4105K8N protein family UPF0079, ATPase C5Q97_08385 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) C5Q97_08390 ENOG4105CAQ asparagine synthetase C5Q97_08395 ENOG4105C3M thioredoxin reductase C5Q97_08420 ENOG4105PGM cation diffusion facilitator family transporter C5Q97_08425 ENOG4105CPQ Dehydrogenase C5Q97_08455 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) C5Q97_08470 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) C5Q97_08475 ENOG4105DJV ribulose-phosphate 3-epimerase C5Q97_08485 ENOG4107QMP dna polymerase iii subunits gamma and tau C5Q97_08505 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) C5Q97_08510 ENOG4105C01 Dihydroxy-acid dehydratase C5Q97_08530 ENOG4105DHJ ABC, transporter C5Q97_08545 ENOG4105C1V Peptidase, M16 C5Q97_08600 ENOG4108BRW Activates expression of the rhaSR operon in response to L-rhamnose (By similarity) C5Q97_08610 ENOG4105CTM Glycoside hydrolase family 5 C5Q97_08615 ENOG4105ETE Transcriptional regulator (LacI family C5Q97_08645 ENOG4105ETE Transcriptional regulator (LacI family C5Q97_08670 ENOG4105CPQ Dehydrogenase C5Q97_08780 ENOG4105C0D helicase C5Q97_08800 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) C5Q97_08805 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) C5Q97_08845 ENOG4108J9M Transporter C5Q97_08850 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN C5Q97_08865 ENOG4108Z7F N-acetyltransferase C5Q97_08875 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase C5Q97_08885 ENOG4108EKI Dehydrogenase C5Q97_08890 ENOG4107TDE lipolytic protein G-D-S-L family C5Q97_08895 ENOG4105VRH Antibiotic biosynthesis monooxygenase C5Q97_08900 ENOG4105CKK Glycosyl transferase, family 2 C5Q97_08920 ENOG4105CPQ Dehydrogenase C5Q97_08930 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) C5Q97_08935 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) C5Q97_08975 ENOG4105ETE Transcriptional regulator (LacI family C5Q97_08985 ENOG4105C8Y Acetylornithine aminotransferase C5Q97_08990 ENOG4105DBV ornithine carbamoyltransferase C5Q97_08995 ENOG4108UI1 Probably functions as a manganese efflux pump (By similarity) C5Q97_09005 ENOG4105CZX twitching motility protein C5Q97_09010 ENOG4105CZX twitching motility protein C5Q97_09015 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme C5Q97_09030 ENOG4105D82 Glutamate dehydrogenase C5Q97_09045 ENOG4105BZ1 (ABC) transporter C5Q97_09055 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control C5Q97_09075 ENOG4108Z7S Single-stranded nucleic acid binding R3H domain-containing protein C5Q97_09080 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins C5Q97_09085 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) C5Q97_09090 ENOG4105NVJ RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) C5Q97_09140 ENOG4107RJ1 sodium solute C5Q97_09150 ENOG4107YCY Transcriptional regulator C5Q97_09155 ENOG4107B7Y DNA-binding transcriptional regulator FruR C5Q97_09180 ENOG4105CMD Transcriptional regulator, GntR family C5Q97_09215 ENOG4105C5H ABC transporter C5Q97_09245 ENOG4105C4C beta-galactosidase C5Q97_09255 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase C5Q97_09260 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) C5Q97_09270 ENOG4107QIZ NADH dehydrogenase C5Q97_09275 ENOG4107QHI -hydrogenase C5Q97_09310 ENOG4105C7H Helicase, RecD TraA family C5Q97_09345 ENOG4105F8D glycoside hydrolase family 4 C5Q97_09350 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) C5Q97_09365 ENOG4105ETE Transcriptional regulator (LacI family C5Q97_09385 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) C5Q97_09395 ENOG4105CQ4 Transcriptional regulator C5Q97_09415 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) C5Q97_09425 ENOG4107ZVW dihydroneopterin aldolase C5Q97_09435 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) C5Q97_09440 ENOG4105C3F Signal peptidase i C5Q97_09450 ENOG4105CA9 Pyruvate kinase C5Q97_09455 ENOG4105CYC Transferase C5Q97_09460 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) C5Q97_09465 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) C5Q97_09470 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) C5Q97_09485 ENOG4107QW8 radical SAM domain protein C5Q97_09495 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) C5Q97_09535 ENOG4105ETE Transcriptional regulator (LacI family C5Q97_09575 ENOG41067D4 cell wall surface anchor family protein C5Q97_09585 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) C5Q97_09590 ENOG41075H3 AraC family transcriptional regulator C5Q97_09625 ENOG4105C3J Cysteine desulfurase C5Q97_09630 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) C5Q97_09645 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family C5Q97_09650 ENOG4105ETE Transcriptional regulator (LacI family C5Q97_09665 ENOG4105C6N Formate acetyltransferase C5Q97_09670 ENOG410874W AraC family transcriptional regulator C5Q97_09685 ENOG4105D6E homoserine dehydrogenase C5Q97_09690 ENOG4105CZK Aspartate kinase C5Q97_09695 ENOG4105DUN Mediates zinc uptake. May also transport other divalent cations (By similarity) C5Q97_09700 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) C5Q97_09710 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) C5Q97_09735 ENOG4105C6N Formate acetyltransferase C5Q97_09750 ENOG4105C8J )-transporter C5Q97_09760 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) C5Q97_09765 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) C5Q97_09770 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) C5Q97_09795 ENOG4105C8B TIGR00159 family C5Q97_09805 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) C5Q97_09810 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase C5Q97_09820 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) C5Q97_09825 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) C5Q97_09830 ENOG4108MDK Dehydrogenase C5Q97_09870 ENOG4105CZE histidine utilization repressor C5Q97_09875 ENOG4108AHH pyruvate formate lyase II activase C5Q97_09925 ENOG4108QXE glycerophosphoryl diester phosphodiesterase C5Q97_09935 ENOG4107RWR Sodium hydrogen exchanger C5Q97_09950 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) C5Q97_09960 ENOG4105C0D helicase C5Q97_09985 ENOG4105MN3 Resolvase C5Q97_10020 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) C5Q97_10030 ENOG4105ESV Glycosyl transferase, family 4 C5Q97_10045 ENOG4105C7K acetolactate synthase C5Q97_10050 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase C5Q97_10055 ENOG4105FAW cDP-glucose 4,6-dehydratase C5Q97_10060 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase C5Q97_10080 ENOG4105CG5 Glycosyl transferase (Group 1 C5Q97_10095 ENOG4107XB0 Lipopolysaccharide 1,2-N-acetylglucosaminetransferase C5Q97_10120 ENOG4107YYJ Glycosyl transferase, family 2 C5Q97_10135 ENOG4105C30 Nad-dependent epimerase dehydratase C5Q97_10140 ENOG4105C0K Gdp-mannose 4,6-dehydratase C5Q97_10150 ENOG4107QQG Dehydrogenase C5Q97_10240 ENOG4105I82 acetyl xylan esterase C5Q97_10250 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) C5Q97_10260 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase C5Q97_10265 ENOG4105FAW cDP-glucose 4,6-dehydratase C5Q97_10280 ENOG4105C7K acetolactate synthase C5Q97_10285 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) C5Q97_10300 ENOG4105EXW epimerase dehydratase C5Q97_10305 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) C5Q97_10310 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) C5Q97_10330 ENOG4105ENT Efflux transporter rnd family, mfp subunit C5Q97_10340 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) C5Q97_10345 ENOG4105DEU major facilitator superfamily C5Q97_10410 ENOG4105FDP GntR family transcriptional regulator C5Q97_10420 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) C5Q97_10445 ENOG4105CEY Amp-dependent synthetase and ligase C5Q97_10450 ENOG4105C5X domain protein C5Q97_10455 ENOG4105DKQ ROK family C5Q97_10460 ENOG4105E2R ROK family C5Q97_10465 ENOG4105E02 MotA TolQ exbB proton channel C5Q97_10470 ENOG4105M8F Biopolymer transport protein exbD tolR C5Q97_10515 ENOG4105DSB aldose 1-epimerase C5Q97_10530 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) C5Q97_10535 ENOG4105C6K Malic enzyme C5Q97_10545 ENOG4105CNT hydrolase family 2 C5Q97_10550 ENOG4108BRW Activates expression of the rhaSR operon in response to L-rhamnose (By similarity) C5Q97_10555 ENOG4105C4R Atp-dependent dna helicase C5Q97_10560 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) C5Q97_10570 ENOG4105FTV AraC Family Transcriptional Regulator C5Q97_10585 ENOG4108KU3 Integrase C5Q97_10690 ENOG4108K2F hydrolase Family 5 C5Q97_10700 ENOG4108ZP8 Acetolactate synthase small subunit C5Q97_10740 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) C5Q97_10755 ENOG4105EMN RNA polymerase sigma factor C5Q97_10760 ENOG4105M6F mutator MutT protein C5Q97_10770 ENOG4105ETE Transcriptional regulator (LacI family C5Q97_10790 ENOG4105ETE Transcriptional regulator (LacI family C5Q97_10860 ENOG4107RES phosphoglycerol transferase I C5Q97_10870 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase C5Q97_10875 ENOG4107EFR Flavocytochrome c C5Q97_10890 ENOG4107QWP ABC-2 type transporter C5Q97_10895 ENOG4107QWP ABC-2 type transporter C5Q97_10900 ENOG4105CJ1 ABC, transporter C5Q97_10910 ENOG4105MA4 psp1 domain protein C5Q97_10935 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) C5Q97_10945 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) C5Q97_10950 ENOG4107Z7S Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) C5Q97_10955 ENOG4107XF7 NGG1p interacting factor 3 protein, NIF3 C5Q97_10995 ENOG4105ETE Transcriptional regulator (LacI family C5Q97_11040 ENOG410903C (LipO)protein C5Q97_11060 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain C5Q97_11065 ENOG4105CKK Glycosyl transferase, family 2 C5Q97_11070 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) C5Q97_11075 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase C5Q97_11080 ENOG4105DXN mazG family C5Q97_11085 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane C5Q97_11090 ENOG4105CDU Replicative dna helicase C5Q97_11095 ENOG4105K9Q Binds to the 23S rRNA (By similarity) C5Q97_11100 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) C5Q97_11105 ENOG4108UUM single-stranded DNA-binding protein C5Q97_11110 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) C5Q97_11115 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) C5Q97_11120 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) C5Q97_11125 ENOG4105C5T Phosphoribosyl pyrophosphate synthase C5Q97_11145 ENOG4105CDY transcriptional regulatory protein C5Q97_11180 ENOG4105W06 Cupin 2, conserved barrel domain protein C5Q97_11185 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) C5Q97_11200 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) C5Q97_11210 ENOG4105C75 arginyL-tRNA synthetase C5Q97_11215 ENOG4105DG6 mannose-6-phosphate isomerase C5Q97_11230 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) C5Q97_11235 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) C5Q97_11240 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) C5Q97_11245 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) C5Q97_11250 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) C5Q97_11255 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) C5Q97_11260 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) C5Q97_11270 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) C5Q97_11275 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) C5Q97_11280 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal C5Q97_11285 ENOG41082SA 50s ribosomal protein l29 C5Q97_11290 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) C5Q97_11300 ENOG41080P9 The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) C5Q97_11315 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) C5Q97_11340 ENOG4105C9M aspartyl-trna synthetase C5Q97_11355 ENOG4105DZ0 fad dependent oxidoreductase C5Q97_11380 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs C5Q97_11390 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase C5Q97_11395 ENOG4105C7K acetolactate synthase C5Q97_11400 ENOG4107Y2H ErfK ybiS ycfS ynhG family protein C5Q97_11405 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) C5Q97_11430 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) C5Q97_11435 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) C5Q97_11440 ENOG4105CM2 brancheD-chain amino acid aminotransferase C5Q97_11450 ENOG4105KCK Peptidoglycan-associated lipoprotein C5Q97_11455 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP C5Q97_11460 ENOG4105D7K pfkb domain protein C5Q97_11465 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) C5Q97_11470 ENOG4105C22 threonyL-tRNA synthetase C5Q97_11475 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) C5Q97_11480 ENOG4105VJV 50s ribosomal protein L35 C5Q97_11485 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) C5Q97_11490 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) C5Q97_11495 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) C5Q97_11500 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) C5Q97_11505 ENOG4105M7K Involved in the transcription termination process (By similarity) C5Q97_11510 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) C5Q97_11515 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) C5Q97_11530 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) C5Q97_11535 ENOG4105CJR Integral membrane protein (MviN C5Q97_11540 ENOG4105ETE Transcriptional regulator (LacI family C5Q97_11565 ENOG4105ETE Transcriptional regulator (LacI family C5Q97_11570 ENOG4105DHQ Histidine kinase C5Q97_11610 ENOG4105CN1 protease C5Q97_11615 ENOG4105CTQ phosphohexokinase C5Q97_11620 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) C5Q97_11625 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) C5Q97_11640 ENOG4105CTC Lipopolysaccharide biosynthesis protein-like protein C5Q97_11655 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family C5Q97_11665 ENOG4108IJ2 phosphate acetyltransferase C5Q97_11670 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) C5Q97_11675 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) C5Q97_11685 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) C5Q97_11690 ENOG4105CUT histidyl-tRNA synthetase C5Q97_11695 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) C5Q97_11700 ENOG4105C8M UPF0272 protein C5Q97_11705 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) C5Q97_11710 ENOG4107R7Y intracellular protease Pfpi family C5Q97_11715 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) C5Q97_11730 ENOG4105CSR polyphosphate kinase 2 C5Q97_11735 ENOG4105CXK mandelate racemase muconate lactonizing C5Q97_11750 ENOG4105CHR reductase C5Q97_11780 ENOG4107Z9R response regulator C5Q97_11785 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) C5Q97_11790 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) C5Q97_11795 ENOG4105G6Z alkaline phosphatase C5Q97_11815 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) C5Q97_11820 ENOG4105BZA Phosphoglycerate kinase C5Q97_11855 ENOG4105DKG l-rhamnose isomerase C5Q97_11865 ENOG4105ETE Transcriptional regulator (LacI family C5Q97_11890 ENOG4108Z03 MAF-like protein C5Q97_11905 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase C5Q97_11910 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein C5Q97_11915 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) C5Q97_11940 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) C5Q97_11945 ENOG4108Z4T Peptidase M50 C5Q97_11950 ENOG4105EGD dinuclear metal center protein, YbgI family C5Q97_11955 ENOG4107QI1 Mate efflux family protein C5Q97_11975 ENOG4105CK6 Two component transcriptional regulator (Winged helix family C5Q97_11980 ENOG4105BZU Histidine kinase C5Q97_11995 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) C5Q97_12000 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) C5Q97_12010 ENOG4105CUY Mechanosensitive ion channel C5Q97_12025 ENOG4105WKZ CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity) C5Q97_12055 ENOG4105D9P serine threonine protein kinase C5Q97_12065 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) C5Q97_12070 ENOG4107R2U Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity) C5Q97_12085 ENOG4105CHM Aminotransferase C5Q97_12090 ENOG4108ZB6 transcriptional regulator AsnC family C5Q97_12095 ENOG4108HPI phosphatidate Cytidylyltransferase C5Q97_12105 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) C5Q97_12110 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) C5Q97_12115 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) C5Q97_12120 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control C5Q97_12140 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) C5Q97_12150 ENOG4105KJV Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) C5Q97_12160 ENOG4105DTN riboflavin biosynthesis protein ribF C5Q97_12165 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) C5Q97_12180 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) C5Q97_12220 ENOG4107RJ1 sodium solute C5Q97_12235 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) C5Q97_12240 ENOG4105FTV AraC Family Transcriptional Regulator C5Q97_12245 ENOG4105DNX Dna topoisomerase iv (Subunit b) C5Q97_12250 ENOG4105DF5 DNA topoisomerase IV, subunit A C5Q97_12255 ENOG4105C4W S-formylglutathione hydrolase C5Q97_12265 ENOG4105CAH Chromate C5Q97_12275 ENOG4105ETE Transcriptional regulator (LacI family C5Q97_12300 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) C5Q97_12310 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) C5Q97_12320 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) C5Q97_12330 ENOG4105EZY Pyrroloquinoline quinone biosynthesis protein E C5Q97_12350 ENOG4105CJ0 Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate (By similarity) C5Q97_12370 ENOG4105CP7 Triose-phosphate isomerase C5Q97_12400 ENOG4105E4G Type IV pilus C5Q97_12405 ENOG4105E4G Type IV pilus C5Q97_12410 ENOG4105CUZ uba thif-type nad fad binding protein C5Q97_12415 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) C5Q97_12430 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) C5Q97_12440 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) C5Q97_12450 ENOG4108M8S permease YjgP YjgQ family protein C5Q97_12465 ENOG4105D9P serine threonine protein kinase C5Q97_12470 ENOG4105C5H ABC transporter C5Q97_12475 ENOG4105C0M Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity) C5Q97_12490 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) C5Q97_12495 ENOG4105D41 biosynthesis protein thiH C5Q97_12500 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family C5Q97_12505 ENOG4105C03 ribonuclease C5Q97_12510 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) C5Q97_12515 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase C5Q97_12535 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) C5Q97_12540 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase C5Q97_12545 ENOG4105CYP glycoside hydrolase, family C5Q97_12550 ENOG4105C7R Atpase associated with various cellular activities aaa_3 C5Q97_12620 ENOG4105FE9 pseudouridine synthase C5Q97_12625 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) C5Q97_12630 ENOG4105CH2 amidohydrolase C5Q97_12635 ENOG4105CD3 dihydroorotase C5Q97_12640 ENOG4105CXT aspartate transcarbamylase C5Q97_12645 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) C5Q97_12655 ENOG4105FDP GntR family transcriptional regulator C5Q97_12665 ENOG4105D9R oxidoreductase C5Q97_12670 ENOG4105CK5 oxidoreductase C5Q97_12680 ENOG4105ETE Transcriptional regulator (LacI family C5Q97_12710 ENOG4108UTW Plays a role in the regulation of phosphate uptake C5Q97_12715 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) C5Q97_12720 ENOG4105E2Z phosphate ABC transporter (Permease C5Q97_12725 ENOG4105C8U phosphate abc transporter C5Q97_12750 ENOG4105HFZ Membrane C5Q97_12755 ENOG4105ETE Transcriptional regulator (LacI family C5Q97_12790 ENOG4105ETE Transcriptional regulator (LacI family C5Q97_12815 ENOG4108V4B ThiJ pfpI C5Q97_12820 ENOG4105D0S secretion protein (HlyD C5Q97_12830 ENOG4108R3E Dna-3-methyladenine glycosylase i C5Q97_12840 ENOG4107QP8 phosphohexose isomerase C5Q97_12855 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) C5Q97_12865 ENOG4105D7Q type ii secretion system C5Q97_12870 ENOG4107QHF type ii secretion system protein e C5Q97_12875 ENOG4107QHF type ii secretion system protein e C5Q97_12880 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) C5Q97_12885 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) C5Q97_12895 ENOG4105EAY pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for C5Q97_12900 ENOG4105CRK lysyL-tRNA synthetase C5Q97_12905 ENOG4108RE9 Phosphodiesterase C5Q97_12910 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) C5Q97_12915 ENOG4105DZB Electron transport complex C5Q97_12920 ENOG4108UQQ Electron transport complex C5Q97_12925 ENOG4105D6A Electron transport complex C5Q97_12930 ENOG4107QTR Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) C5Q97_12935 ENOG4107SVV electron transport complex, RnfABCDGE type, B subunit C5Q97_12940 ENOG4105DGN Electron transport complex C5Q97_12960 ENOG4105ESV Glycosyl transferase, family 4 C5Q97_12965 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) C5Q97_12975 ENOG4107XPQ Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) C5Q97_12980 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving C5Q97_12985 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) C5Q97_12990 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) C5Q97_12995 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) C5Q97_13000 ENOG4105VB6 UPF0109 protein C5Q97_13005 ENOG4105K5M 30s ribosomal protein S16 C5Q97_13015 ENOG4107KJX Transcriptional regulator C5Q97_13020 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) C5Q97_13030 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) C5Q97_13050 ENOG4105N5T Radical SAM Protein C5Q97_13070 ENOG4105CTC Lipopolysaccharide biosynthesis protein-like protein C5Q97_13090 ENOG4107RUZ Sss sodium solute transporter superfamily C5Q97_13105 ENOG4105VXP Protein of unknown function DUF86 C5Q97_13120 ENOG4108JA2 transcriptioN-repair coupling factor C5Q97_13130 ENOG4105EE0 oxidoreductase C5Q97_13135 ENOG4105D9P serine threonine protein kinase C5Q97_13140 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) C5Q97_13145 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) C5Q97_13150 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation C5Q97_13160 ENOG4105CNT hydrolase family 2 C5Q97_13165 ENOG4105ETE Transcriptional regulator (LacI family C5Q97_13170 ENOG4105C4C beta-galactosidase C5Q97_13235 ENOG4108R66 Conserved Protein C5Q97_13305 ENOG4105VTR Integrase C5Q97_13315 ENOG4105CMI transporter C5Q97_13320 ENOG4105CJ1 ABC, transporter C5Q97_13325 ENOG4105D0S secretion protein (HlyD C5Q97_13345 ENOG4105ETE Transcriptional regulator (LacI family C5Q97_13375 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) C5Q97_13380 ENOG4108RY1 ATP synthase, subunit E C5Q97_13385 ENOG41069SF C5Q97_13390 ENOG4107RVI Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit (By similarity) C5Q97_13395 ENOG4107RQX Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit C5Q97_13400 ENOG4108WBK V-type ATP synthase subunit D C5Q97_13405 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) C5Q97_13410 ENOG4105DET Rhamnulokinase C5Q97_13445 ENOG41080XP Cbs domain C5Q97_13450 ENOG4108J9M Transporter C5Q97_13475 ENOG4105D2H Uronic isomerase C5Q97_13480 ENOG4105CXB phosphoribosylaminoimidazole synthetase C5Q97_13520 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) C5Q97_13525 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) C5Q97_13540 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) C5Q97_13565 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) C5Q97_13570 ENOG4105WDJ 50S ribosomal protein L33 C5Q97_13590 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) C5Q97_13595 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) C5Q97_13600 ENOG4108VZM 50s ribosomal protein L10 C5Q97_13605 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) C5Q97_13610 ENOG4107QIH DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) C5Q97_13615 ENOG4107QR0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) C5Q97_13620 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) C5Q97_13625 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) C5Q97_13630 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) C5Q97_13635 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) C5Q97_13640 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) C5Q97_13645 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) C5Q97_13650 ENOG41080UE One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) C5Q97_13655 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity C5Q97_13660 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) C5Q97_13665 ENOG4107QN2 dihydrolipoyl dehydrogenase C5Q97_13670 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) C5Q97_13675 ENOG41080R2 UPF0102 protein C5Q97_13680 ENOG4105MJ2 Competence protein C5Q97_13700 ENOG4105C6N Formate acetyltransferase C5Q97_13705 ENOG4105F1A Pyruvate formate-lyase C5Q97_13710 ENOG4105D9P serine threonine protein kinase C5Q97_13720 ENOG4105I82 acetyl xylan esterase C5Q97_13735 ENOG4105CNT hydrolase family 2 C5Q97_13740 ENOG4105ETE Transcriptional regulator (LacI family C5Q97_13745 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) C5Q97_13765 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase C5Q97_13770 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) C5Q97_13775 ENOG4105CAS nag kinase C5Q97_13790 ENOG41088YA Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives (By similarity) C5Q97_13800 ENOG4106AM8 polysaccharide lyase family 8 C5Q97_13860 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) C5Q97_13875 ENOG4105DY2 Paraquat-inducible protein b C5Q97_13885 ENOG4107S4Z Activates expression of the rhaBAD and rhaT operons (By similarity) C5Q97_13890 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) C5Q97_13900 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) C5Q97_13920 ENOG4105CTM Glycoside hydrolase family 5 C5Q97_13925 ENOG4105CKB glycosidase C5Q97_13935 ENOG4105I82 acetyl xylan esterase C5Q97_13990 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) C5Q97_14010 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) C5Q97_14015 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase C5Q97_14030 ENOG4105DB7 PHP domain protein C5Q97_14035 ENOG4108BVD Ribosomal protein S21 C5Q97_14040 ENOG4105DPN Oligoendopeptidase f C5Q97_14045 ENOG4105CIH Imidazole acetol-phosphate transaminase C5Q97_14050 ENOG4108QXE glycerophosphoryl diester phosphodiesterase C5Q97_14055 ENOG4105DZ1 carboxypeptidase C5Q97_14060 ENOG4107QXN Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) C5Q97_14065 ENOG4105DTC 1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (air) carboxylase C5Q97_14070 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) C5Q97_14130 ENOG4108HKT sucrose-6-phosphate hydrolase C5Q97_14135 ENOG41075H3 AraC family transcriptional regulator C5Q97_14165 ENOG4108HMX isocitrate dehydrogenase (NADP) C5Q97_14185 ENOG4105CTM Glycoside hydrolase family 5 C5Q97_14190 ENOG4105DFD Na H antiporter C5Q97_14215 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) C5Q97_14230 ENOG4105C5X domain protein C5Q97_14235 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) C5Q97_14240 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) C5Q97_14280 ENOG4105WBN Transcriptional regulator (LacI family C5Q97_14290 ENOG4105CNT hydrolase family 2 C5Q97_14300 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) C5Q97_14305 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) C5Q97_14310 ENOG41081FY multiple antibiotic resistance (MarC)-related C5Q97_14320 ENOG4105ETE Transcriptional regulator (LacI family C5Q97_14335 ENOG410863N 50S ribosomal protein L32 C5Q97_14340 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) C5Q97_14345 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) C5Q97_14355 ENOG41066A3 ATP guanido phosphotransferase C5Q97_14360 ENOG4105CMD Transcriptional regulator, GntR family C5Q97_14375 ENOG4107RGM aldo keto reductase C5Q97_14390 ENOG4105FDP GntR family transcriptional regulator C5Q97_14395 ENOG4105CMD Transcriptional regulator, GntR family C5Q97_14415 ENOG4108QXE glycerophosphoryl diester phosphodiesterase C5Q97_14420 ENOG4106HBX Transcriptional Regulator AraC Family C5Q97_14435 ENOG4107QKW extracellular solute-binding protein family 1 C5Q97_14440 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) C5Q97_14445 ENOG4105CTM Glycoside hydrolase family 5 C5Q97_14500 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase C5Q97_14515 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) C5Q97_14520 ENOG4105CNI cell division protein FtsW C5Q97_14525 ENOG4108MYC UTP-glucose-1-phosphate uridylyltransferase C5Q97_14535 ENOG4106855 Competence protein C5Q97_14540 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) C5Q97_14550 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) C5Q97_14555 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) C5Q97_14565 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) C5Q97_14580 ENOG4105D4P Coproporphyrinogen iii oxidase C5Q97_14585 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) C5Q97_14590 ENOG4108U1V ABC transporter, permease C5Q97_14595 ENOG4105E0A ABC, transporter C5Q97_14600 ENOG4107PPM cobalt chelatase C5Q97_14605 ENOG4105DVK Precorrin-2 c20-methyltransferase C5Q97_14615 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) C5Q97_14620 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase C5Q97_14630 ENOG4105EE8 May catalyze the methylation of C-1 in cobalt-precorrin- 5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A (By similarity) C5Q97_14635 ENOG4105CX4 Precorrin-6y C5,15-methyltransferase C5Q97_14640 ENOG4105CIA precorrin-4 C(11)-methyltransferase C5Q97_14645 ENOG4105E4R Precorrin-3B C17-methyltransferase C5Q97_14650 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) C5Q97_14655 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) C5Q97_14670 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) C5Q97_14690 ENOG4107B7Y DNA-binding transcriptional regulator FruR C5Q97_14715 ENOG4107QX8 SPFH domain, Band 7 family protein C5Q97_14855 ENOG4105C59 p-type ATPase C5Q97_14890 ENOG4105C8V SAICAR synthetase C5Q97_14895 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) C5Q97_14930 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) C5Q97_14935 ENOG4105T16 Transcriptional regulator (AraC family) C5Q97_14940 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) C5Q97_14955 ENOG4105C3J Cysteine desulfurase C5Q97_14970 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase C5Q97_14975 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) C5Q97_14990 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) C5Q97_14995 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) C5Q97_15005 ENOG4105C31 Tryptophanyl-tRNA synthetase C5Q97_15015 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) C5Q97_15030 ENOG4105ETE Transcriptional regulator (LacI family C5Q97_15035 ENOG4105ETE Transcriptional regulator (LacI family C5Q97_15045 ENOG4105CNT hydrolase family 2 C5Q97_15055 ENOG4105G6Z alkaline phosphatase C5Q97_15065 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) C5Q97_15070 ENOG4105FTV AraC Family Transcriptional Regulator C5Q97_15080 ENOG4108Q52 Methyltransferase cognate corrinoid protein C5Q97_15105 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) C5Q97_15115 ENOG41071I4 Phosphatidylserine decarboxylase proenzyme C5Q97_15120 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase C5Q97_15145 ENOG4108X7C Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) C5Q97_15150 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) C5Q97_15215 ENOG4105ETE Transcriptional regulator (LacI family C5Q97_15220 ENOG4106855 Competence protein C5Q97_15240 ENOG4105CN9 Peptidase m42 family protein C5Q97_15250 ENOG4105FDP GntR family transcriptional regulator C5Q97_15300 ENOG4105ETE Transcriptional regulator (LacI family C5Q97_15310 ENOG4105C1P efflux transporter, rnd family, mfp subunit C5Q97_15320 ENOG41060NJ transcriptional regulator C5Q97_15340 ENOG4105CF7 AraC family transcriptional regulator C5Q97_15365 ENOG4105CHR reductase C5Q97_15370 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) C5Q97_15375 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) C5Q97_15380 ENOG4109066 lysm domain bon superfamily protein C5Q97_15385 ENOG4105C9A Phoh family C5Q97_15395 ENOG4107Z9E Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) C5Q97_15415 ENOG4105M2Z protein tyrosine serine phosphatase C5Q97_15430 ENOG4105C25 Primosomal protein n' C5Q97_15450 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) C5Q97_15455 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) C5Q97_15475 ENOG4105CK5 oxidoreductase C5Q97_15485 ENOG4105CPK Glycosyl transferase (Group 1 C5Q97_15500 ENOG4105ETE Transcriptional regulator (LacI family C5Q97_15525 ENOG4105C0H protease C5Q97_15530 ENOG4105C0H protease C5Q97_15535 ENOG4105DUM transcriptional regulator, lysR family C5Q97_15540 ENOG4105HMI Membrane C5Q97_15545 ENOG4105D9R oxidoreductase C5Q97_15555 ENOG4105D3Y Na H antiporter C5Q97_15560 ENOG4108DWA Nad synthetase C5Q97_15565 ENOG4105ETE Transcriptional regulator (LacI family C5Q97_15595 ENOG4105ECQ AraC Family Transcriptional Regulator C5Q97_15600 ENOG4105ESV Glycosyl transferase, family 4 C5Q97_15605 ENOG4108RB3 Capsular polysaccharide biosynthesis protein C5Q97_15610 ENOG4105D75 Capsular exopolysaccharide family C5Q97_15685 ENOG4107QHF type ii secretion system protein e C5Q97_15695 ENOG4108VAU general secretion pathway protein G C5Q97_15725 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family C5Q97_15750 ENOG4107SFF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) C5Q97_15755 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) C5Q97_15770 ENOG410804T Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) C5Q97_15775 ENOG4105C8Y Acetylornithine aminotransferase C5Q97_15780 ENOG4105CS1 NAD(P)H quinone oxidoreductase C5Q97_15785 ENOG4105W5Q DNA repair protein (RadC C5Q97_15790 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) C5Q97_15800 ENOG4105BZ1 (ABC) transporter C5Q97_15805 ENOG4105DFU Cell wall formation (By similarity) C5Q97_15845 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) C5Q97_15850 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) C5Q97_15855 ENOG4105DRR Transcriptional regulator, GntR family C5Q97_15890 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase C5Q97_15895 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) C5Q97_15900 ENOG4105C1B dTDP-glucose 4-6-dehydratase C5Q97_15940 ENOG4108ZT0 50S ribosomal protein l17 C5Q97_15945 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) C5Q97_15950 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) C5Q97_15960 ENOG41067V7 50S ribosomal protein L36 C5Q97_15980 ENOG4105CG6 trap dicarboxylate transporter dctm subunit C5Q97_15990 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit C5Q97_15995 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) C5Q97_16060 ENOG4105MN3 Resolvase C5Q97_16110 ENOG4108APS Essential cell division protein (By similarity) C5Q97_16115 ENOG4105ETE Transcriptional regulator (LacI family C5Q97_16135 ENOG4105ETE Transcriptional regulator (LacI family C5Q97_16140 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) C5Q97_16175 ENOG4108ZF3 Phosphatase C5Q97_16190 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) C5Q97_16195 ENOG4105VZ9 UPF0235 protein C5Q97_16200 ENOG4105E3H phosphoglycerate mutase C5Q97_16210 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) C5Q97_16215 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B C5Q97_16230 ENOG4105CMQ Chloride channel C5Q97_16280 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase C5Q97_16285 ENOG4105E4Y Endoribonuclease that initiates mRNA decay (By similarity) C5Q97_16290 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) C5Q97_16295 ENOG4105C26 Dehydrogenase C5Q97_16300 ENOG4107QKV phosphomannomutase C5Q97_16310 ENOG4105PTV Nudix Hydrolase C5Q97_16315 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component C5Q97_16330 ENOG4105E98 transcriptional regulator DeoR family C5Q97_16340 ENOG4105ETE Transcriptional regulator (LacI family C5Q97_16395 ENOG4105ETE Transcriptional regulator (LacI family C5Q97_16400 ENOG4105CNT hydrolase family 2 C5Q97_16425 ENOG4107TRE AP endonuclease, family 2 C5Q97_16440 ENOG4107S4Z Activates expression of the rhaBAD and rhaT operons (By similarity) C5Q97_16455 ENOG4105ETE Transcriptional regulator (LacI family C5Q97_16460 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) C5Q97_16480 ENOG4105CMD Transcriptional regulator, GntR family C5Q97_16500 ENOG4105CNI cell division protein FtsW C5Q97_16505 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis C5Q97_16510 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) C5Q97_16515 ENOG4107U1W v-type ATP synthase subunit I C5Q97_16535 ENOG4105D3R alkyl hydroperoxide reductase C5Q97_16570 ENOG4105C6N Formate acetyltransferase C5Q97_16590 ENOG4108V0P LemA family C5Q97_16595 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) C5Q97_16640 ENOG4105D5Q Arginine ornithine antiporter C5Q97_16645 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) C5Q97_16665 ENOG4105F7V ErfK ybiS ycfS ynhG family protein C5Q97_16685 ENOG4105C8T Leucyl-tRNA synthetase C5Q97_16705 ENOG4105CNV Aldolase C5Q97_16710 ENOG4105C05 Multifunctional regulator of fatty acid metabolism (By similarity) C5Q97_16725 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) C5Q97_16755 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) C5Q97_16765 ENOG4105CNT hydrolase family 2 C5Q97_16800 ENOG4105D64 Mechanosensitive ion channel C5Q97_16865 ENOG4107SQD Transcriptional regulator, GntR family C5Q97_16905 ENOG4105C59 p-type ATPase C5Q97_16910 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) C5Q97_16920 ENOG4105ESV Glycosyl transferase, family 4 C5Q97_16935 ENOG4105DC1 bifunctional purine biosynthesis protein purh C5Q97_16940 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) C5Q97_16945 ENOG4107QRG dna polymerase iii C5Q97_16950 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) C5Q97_16955 ENOG4108I2E Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto- arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4- amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido- arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) C5Q97_16960 ENOG4105F73 Catalyzes the deformylation of 4-deoxy-4-formamido-L- arabinose-phosphoundecaprenol to 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) C5Q97_16970 ENOG4107QIZ NADH dehydrogenase C5Q97_16980 ENOG4105DMQ Methyltransferase C5Q97_16985 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) C5Q97_17005 ENOG4105C6X Major Facilitator C5Q97_17020 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate C5Q97_17035 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) C5Q97_17045 ENOG4105DWV Homoserine O-trans-acetylase C5Q97_17050 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) C5Q97_17070 ENOG4105NA0 Transcriptional regulator C5Q97_17080 ENOG4105F6J Alpha beta hydrolase fold C5Q97_17090 ENOG4105T16 Transcriptional regulator (AraC family) C5Q97_17095 ENOG4105D9R oxidoreductase C5Q97_17110 ENOG41080Z8 PHOSPHOCARRIER protein C5Q97_17115 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) C5Q97_17125 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) C5Q97_17130 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase C5Q97_17135 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) C5Q97_17140 ENOG4105M10 Involved in the anomeric conversion of L-rhamnose (By similarity) C5Q97_17155 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) C5Q97_17160 ENOG41082EZ Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) C5Q97_17165 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) C5Q97_17170 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) C5Q97_17175 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) C5Q97_17180 ENOG41080ZE Adenylate cyclase C5Q97_17185 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) C5Q97_17195 ENOG4105C2J ABC transporter C5Q97_17200 ENOG4105CNN ABC, transporter C5Q97_17205 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator C5Q97_17220 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) C5Q97_17235 ENOG4105FDP GntR family transcriptional regulator C5Q97_17245 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) C5Q97_17265 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) C5Q97_17320 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) C5Q97_17325 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) C5Q97_17330 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) C5Q97_17340 ENOG4105DZS Phenylacetate-CoA ligase C5Q97_17365 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) C5Q97_17375 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) C5Q97_17380 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) C5Q97_17385 ENOG4105CHV Transcription elongation factor NusA C5Q97_17410 ENOG4105DKW ABC transporter C5Q97_17440 ENOG4105W4W Transcriptional regulator C5Q97_17445 ENOG4105F8D glycoside hydrolase family 4 C5Q97_17455 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) C5Q97_17460 ENOG4105D48 metallophosphoesterase C5Q97_17495 ENOG4107QHF type ii secretion system protein e C5Q97_17510 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) C5Q97_17520 ENOG4105CHR reductase C5Q97_17535 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase C5Q97_17555 ENOG4105I82 acetyl xylan esterase C5Q97_17560 ENOG4105I82 acetyl xylan esterase C5Q97_17570 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) C5Q97_17585 ENOG41082UU Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) C5Q97_17595 ENOG4105I82 acetyl xylan esterase C5Q97_17605 ENOG4105D2N Aldolase C5Q97_17610 ENOG4105VYW UPF0251 protein C5Q97_17620 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) C5Q97_17650 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) C5Q97_17655 ENOG4105KIS phospholipid-binding protein C5Q97_17660 ENOG4105M0C cytoplasmic protein C5Q97_17670 ENOG4105DJ4 phosphatidylserine decarboxylase C5Q97_17685 ENOG4108Z6B deaminase C5Q97_17695 ENOG4108YZA Nitrogen regulatory protein pii C5Q97_17745 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) C5Q97_17750 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) C5Q97_17755 ENOG4108YZ4 nudix hydrolase C5Q97_17775 ENOG4105DDC Oxidoreductase domain protein C5Q97_17795 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme C5Q97_17805 ENOG4105C6N Formate acetyltransferase C5Q97_17810 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) C5Q97_17825 ENOG4108IAB Phoh family C5Q97_17850 ENOG41060NJ transcriptional regulator C5Q97_17865 ENOG4105K6S Short-chain dehydrogenase reductase Sdr C5Q97_17900 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) C5Q97_17935 ENOG4105FKQ transcriptional regulator C5Q97_17940 ENOG4105CKB glycosidase C5Q97_17970 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) C5Q97_17990 ENOG4105DVT helicase C5Q97_18010 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) C5Q97_18040 ENOG4105CAG UPF0210 protein C5Q97_18045 ENOG4105VUC UPF0237 protein C5Q97_18065 ENOG4105BZU Histidine kinase C5Q97_18100 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) C5Q97_18105 ENOG4107QI1 Mate efflux family protein C5Q97_18135 ENOG4105E09 nadh pyrophosphatase C5Q97_18140 ENOG4105F8V Hydrolase, tatD family C5Q97_18155 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) C5Q97_18160 ENOG4105SKN orotidine 5''-phosphate decarboxylase C5Q97_18165 ENOG4106PBJ Serine threonine-protein kinase Pkn6 C5Q97_18185 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) C5Q97_18190 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) C5Q97_18195 ENOG4107WMG L,D-carboxypeptidase C5Q97_18235 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase C5Q97_18235 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase C5Q97_18240 ENOG4105C34 Pseudouridine synthase C5Q97_18265 ENOG4105CFP Peptidase U32 C5Q97_18285 ENOG4107QQG Dehydrogenase C5Q97_18295 ENOG4105CPF Cell wall formation (By similarity) C5Q97_18380 ENOG4105C5E polysaccharide biosynthesis protein C5Q97_18395 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase C5Q97_18400 ENOG4105JNK Glycosyl transferase (Group 1 C5Q97_18420 ENOG4105C30 Nad-dependent epimerase dehydratase C5Q97_18455 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase C5Q97_18465 ENOG4105CNT hydrolase family 2 C5Q97_18475 ENOG4105E4G Type IV pilus C5Q97_18485 ENOG4105C08 Histidine kinase C5Q97_18490 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) C5Q97_18500 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) C5Q97_18510 ENOG4105BZU Histidine kinase C5Q97_18515 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family C5Q97_18525 ENOG4108HQS Glycine betaine C5Q97_18530 ENOG4108IJ7 Glycine betaine C5Q97_18545 ENOG4107U9V N5-(Carboxyethyl)ornithine synthase C5Q97_18560 ENOG4105CYP glycoside hydrolase, family C5Q97_18585 ENOG4105CNT hydrolase family 2 C5Q97_18615 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) C5Q97_18625 ENOG4105DQ4 alcohol dehydrogenase C5Q97_18635 ENOG4105D9P serine threonine protein kinase C5Q97_18645 ENOG4105ENX hydrolase C5Q97_18650 ENOG4105CPC Aldo Keto reductase C5Q97_18660 ENOG4105E4P ATPase (AAA C5Q97_18665 ENOG4105E4P ATPase (AAA C5Q97_18680 ENOG4105CNA YD repeat protein C5Q97_18685 ENOG4108J1Q C5Q97_18860 ENOG4105KK6 nuclease C5Q97_18945 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) C5Q97_18965 ENOG410636K Effects nucleoid occlusion by binding relatively nonspecifically to DNA and preventing the assembly of the division machinery in the vicinity of the nucleoid, especially under conditions that disturb the cell cycle. It helps to coordinate cell division and chromosome segregation by preventing the formation of the Z ring through the nucleoid, which would cause chromosome breakage (By similarity) C5Q97_19005 ENOG4108UUM single-stranded DNA-binding protein C5Q97_19055 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) C5Q97_19060 ENOG4105E0Y RtcB Protein C5Q97_19065 ENOG4105CKX Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP C5Q97_19070 ENOG4105CYB regulatoR C5Q97_19100 ENOG4105ETE Transcriptional regulator (LacI family C5Q97_19125 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) C5Q97_19150 ENOG4106855 Competence protein C5Q97_19165 ENOG4105ETE Transcriptional regulator (LacI family C5Q97_19175 ENOG4105BZU Histidine kinase C5Q97_19180 ENOG4105BZU Histidine kinase C5Q97_19185 ENOG4105BZU Histidine kinase C5Q97_19190 ENOG4105D9P serine threonine protein kinase C5Q97_19205 ENOG4105D3Q Sugar transferase C5Q97_19225 ENOG4105DAY polysaccharide export protein C5Q97_19245 ENOG4105K64 Glycosyl transferase, family 2 C5Q97_19250 ENOG4105K64 Glycosyl transferase, family 2 C5Q97_19260 ENOG4105E08 Glycoside hydrolase, family 9 C5Q97_19285 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) C5Q97_19305 ENOG4105ETE Transcriptional regulator (LacI family C5Q97_19310 ENOG4106855 Competence protein C5Q97_19355 ENOG4108URH decarboxylase C5Q97_19365 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit C5Q97_19370 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) C5Q97_19375 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) C5Q97_19405 ENOG4105D9P serine threonine protein kinase C5Q97_19420 ENOG4105CTD carboxy-peptidase C5Q97_19425 ENOG4105BZV Phosphoadenosine phosphosulfate reductase C5Q97_19430 ENOG4105GTN ParB Domain Protein Nuclease C5Q97_19435 ENOG4108RAC Rubrerythrin C5Q97_19460 ENOG4105BZ1 (ABC) transporter C5Q97_19480 ENOG4108YZN class I peptide chain release factor C5Q97_19500 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) C5Q97_19515 ENOG4108EE5 Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) C5Q97_19520 ENOG4108EE5 Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) C5Q97_19530 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) C5Q97_19540 ENOG4105E27 serine threonine protein kinase C5Q97_19545 ENOG4108BRW Activates expression of the rhaSR operon in response to L-rhamnose (By similarity) C5Q97_19565 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase C5Q97_19570 ENOG41080HT Transcriptional regulator, arsr family C5Q97_19575 ENOG4105K5X acetyltransferase C5Q97_19580 ENOG4105M4B Catalyzes the transfer of an acetyl group from acetyl- CoA to the 6'-amino group of aminoglycoside molecules conferring resistance to antibiotics containing the purpurosamine ring (By similarity) C5Q97_19585 ENOG4106P55 Transcriptional regulator C5Q97_19595 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) C5Q97_19615 ENOG4105BZW Glycerate kinase C5Q97_19620 ENOG4105CEV competence damage-inducible protein C5Q97_19630 ENOG4105CIN aminoacyl-histidine dipeptidase C5Q97_19635 ENOG4105MH8 Thioredoxin disulfide isomerase C5Q97_19640 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) C5Q97_19650 ENOG4107SJ9 decarboxylase C5Q97_19665 ENOG4105DND Transcriptional regulator C5Q97_19685 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) C5Q97_19690 ENOG4105CE4 GlcNAc 6-P deacetylase C5Q97_19705 ENOG4108W0I acetyltransferase C5Q97_19725 ENOG4107SJB teichoic acid biosynthesis C5Q97_19730 ENOG4107RJ7 Glycosyl transferase (Group 1 C5Q97_19735 ENOG4107543 (lipo)polysaccharide C5Q97_19745 ENOG4105C2J ABC transporter C5Q97_19750 ENOG4105CNN ABC, transporter C5Q97_19765 ENOG4105ETE Transcriptional regulator (LacI family C5Q97_19770 ENOG4105K8R UPF0145 protein C5Q97_19775 ENOG4105K8R UPF0145 protein C5Q97_19795 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) C5Q97_19810 ENOG4105DSJ YicC domain protein C5Q97_19815 ENOG4105D7W serine acetyltransferase C5Q97_19820 ENOG4105DFA alanine racemase domain protein C5Q97_19825 ENOG41084M5 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) C5Q97_19850 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain C5Q97_19855 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) C5Q97_19860 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain C5Q97_19865 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase C5Q97_19885 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) C5Q97_19890 ENOG4105CHM Aminotransferase C5Q97_19895 ENOG4108JUA Transcriptional regulator C5Q97_19900 ENOG4108Z0Z intracellular protease Pfpi family C5Q97_19905 ENOG4108RAC Rubrerythrin C5Q97_19910 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) C5Q97_19915 ENOG4105CJN penicillin-binding protein C5Q97_19930 ENOG4107QWG 2-Nitropropane dioxygenase C5Q97_19940 ENOG4105DWF phosphomethylpyrimidine kinase C5Q97_20010 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) C5Q97_20015 ENOG4105ETE Transcriptional regulator (LacI family C5Q97_20025 ENOG4105CTM Glycoside hydrolase family 5 C5Q97_20045 ENOG410667J hydrolase C5Q97_20055 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase C5Q97_20060 ENOG4105C1J atp-dependent rna helicase C5Q97_20065 ENOG4105BZU Histidine kinase C5Q97_20075 ENOG4105R0I Feruloyl esterase C5Q97_20095 ENOG4107RJ1 sodium solute C5Q97_20115 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) C5Q97_20130 ENOG4108V0P LemA family C5Q97_20135 ENOG4105D0M Protease HtpX homolog C5Q97_20145 ENOG4105ETE Transcriptional regulator (LacI family C5Q97_20165 ENOG4105BZ1 (ABC) transporter C5Q97_20200 ENOG4108EKI Dehydrogenase C5Q97_20250 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) C5Q97_20260 ENOG4105CMD Transcriptional regulator, GntR family C5Q97_20275 ENOG4105CT4 transporter C5Q97_20310 ENOG4108CSZ Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) C5Q97_20330 ENOG4105CPC Aldo Keto reductase C5Q97_20365 ENOG4106P55 Transcriptional regulator C5Q97_20385 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) C5Q97_20390 ENOG41083AI transcriptional regulator), MarR family C5Q97_20415 ENOG4105CNT hydrolase family 2 C5Q97_20485 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family C5Q97_20490 ENOG4107SFF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) C5Q97_20535 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component C5Q97_20545 ENOG4105EIG urea carboxylase-associated protein 1 C5Q97_20550 ENOG4105EIG urea carboxylase-associated protein 1 C5Q97_20555 ENOG4105EIG urea carboxylase-associated protein 1 C5Q97_20605 ENOG4105DDI hemolysin-type calcium-binding region C5Q97_20610 ENOG4105DDI hemolysin-type calcium-binding region C5Q97_20620 ENOG4105ETE Transcriptional regulator (LacI family C5Q97_20650 ENOG4105BZ1 (ABC) transporter C5Q97_20670 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) C5Q97_20690 ENOG4107XM9 (LipO)protein C5Q97_20710 ENOG4105CTQ phosphohexokinase C5Q97_20730 ENOG4105BZJ Electron transfer flavoprotein C5Q97_20735 ENOG4105C10 Electron transfer flavoprotein C5Q97_20740 ENOG4105C1G acyl-Coa dehydrogenase C5Q97_20745 ENOG4105VFG Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) C5Q97_20750 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) C5Q97_20755 ENOG41081FY multiple antibiotic resistance (MarC)-related C5Q97_20760 ENOG4108ME1 Peptidase M55 D-aminopeptidase C5Q97_20770 ENOG41083UI stage II sporulation protein C5Q97_20780 ENOG4108JJA ABC, transporter C5Q97_20790 ENOG4105CE4 GlcNAc 6-P deacetylase C5Q97_20800 ENOG4106HBX Transcriptional Regulator AraC Family C5Q97_20820 ENOG4105DDV Transcriptional regulator (LacI family C5Q97_20870 ENOG4107S4Z Activates expression of the rhaBAD and rhaT operons (By similarity) C5Q97_20890 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family C5Q97_20910 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) C5Q97_20915 ENOG4105EAC phosphoserine phosphatase C5Q97_20925 ENOG4105C0D helicase C5Q97_20950 ENOG4105CRQ synthase (Component I) C5Q97_20955 ENOG4105DDQ anthranilate synthase C5Q97_20960 ENOG4107QYG anthranilate phosphoribosyltransferase C5Q97_20965 ENOG4105DK0 Indole-3-glycerol phosphate synthase C5Q97_20970 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase C5Q97_20975 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) C5Q97_20980 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) C5Q97_21000 ENOG4107YM4 Beta-lactamase domain-containing protein C5Q97_21010 ENOG4105EQD regulatoR C5Q97_21060 ENOG4105CXK mandelate racemase muconate lactonizing C5Q97_21075 ENOG4105D9F endo-1,4-beta-xylanase (EC 3.2.1.8) C5Q97_21080 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) C5Q97_21085 ENOG4105CHR reductase C5Q97_21090 ENOG4105CJ0 Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate (By similarity) C5Q97_21105 ENOG4105ECY inositol monophosphatase C5Q97_21120 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) C5Q97_21135 ENOG4105ENX hydrolase C5Q97_21165 ENOG4105F1A Pyruvate formate-lyase C5Q97_21195 ENOG4105CQ7 ATP-dependent helicase C5Q97_21205 ENOG4105ECC imidazole-glycerol-phosphate dehydratase C5Q97_21215 ENOG4105BZU Histidine kinase C5Q97_21225 ENOG4105E98 transcriptional regulator DeoR family C5Q97_21240 ENOG4105DH8 myo-inositol catabolism C5Q97_21245 ENOG4105CMG Carbohydrate kinase C5Q97_21250 ENOG4105CQB FAD linked oxidase domain protein C5Q97_21260 ENOG4105D2N Aldolase C5Q97_21270 ENOG4107QJQ Mate efflux family protein C5Q97_21280 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) C5Q97_21315 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) C5Q97_21350 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) C5Q97_21355 ENOG4108IYU L-aspartate oxidase C5Q97_21360 ENOG4105DJ0 Poly(A) Polymerase C5Q97_21365 ENOG4105F32 YngK protein C5Q97_21370 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) C5Q97_21390 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) C5Q97_21395 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) C5Q97_21400 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ C5Q97_21410 ENOG41073TP transcriptional regulator C5Q97_21415 ENOG4105CNT hydrolase family 2 C5Q97_21420 ENOG4105ETE Transcriptional regulator (LacI family C5Q97_21435 ENOG4105CSR polyphosphate kinase 2 C5Q97_21440 ENOG4105HY2 Glycosidase related protein C5Q97_21455 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) C5Q97_21485 ENOG4105CQ4 Transcriptional regulator