locus-tag class description BME96_00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) BME96_00020 ENOG410848D S4 domain protein YaaA BME96_00025 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) BME96_00035 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BME96_00040 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BME96_00045 ENOG4105DHT Metal Dependent Phosphohydrolase BME96_00055 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) BME96_00065 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) BME96_00070 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) BME96_00075 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) BME96_00080 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) BME96_00085 ENOG4108UMI ABC transporter, permease BME96_00115 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) BME96_00120 ENOG4105ZMH deoxynucleoside kinase BME96_00150 ENOG4105F99 Hydroxymethylglutaryl-CoA synthase BME96_00155 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) BME96_00160 ENOG4105KPV Transcriptional regulator BME96_00165 ENOG4107RKG DJ-1/PfpI family BME96_00170 ENOG4105VRS hydrolase family 18 BME96_00175 ENOG4105GTG Isochorismatase BME96_00180 ENOG4108Z6B deaminase BME96_00195 ENOG4105C6E dna polymerase iii BME96_00200 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) BME96_00205 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) BME96_00225 ENOG4105CXN decarboxylase BME96_00230 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) BME96_00235 ENOG4105X0R protein from nitrogen regulatory protein P-II BME96_00240 ENOG4105XVJ Protein of unknown function (DUF327) BME96_00245 ENOG4105FA2 dna polymerase iii BME96_00250 ENOG4105MA4 psp1 domain protein BME96_00255 ENOG4105QD5 Involved in initiation control of chromosome replication (By similarity) BME96_00260 ENOG41060K3 Methyltransferase BME96_00265 ENOG4105VC4 domain protein BME96_00270 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) BME96_00280 ENOG4105KRN Transcriptional regulator, abrb family BME96_00290 ENOG4105F8V Hydrolase, tatD family BME96_00295 ENOG41069ER domain protein BME96_00305 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) BME96_00310 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) BME96_00315 ENOG4105XFA sporulation peptidase YabG BME96_00320 ENOG4105W42 Veg protein BME96_00330 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) BME96_00335 ENOG4105DFT pur operon repressor BME96_00340 ENOG4105K4W Could be involved in septation (By similarity) BME96_00345 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) BME96_00350 ENOG4105C5T Phosphoribosyl pyrophosphate synthase BME96_00355 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) BME96_00360 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) BME96_00370 ENOG4108JA2 transcriptioN-repair coupling factor BME96_00375 ENOG4108M14 stage v sporulation protein t BME96_00385 ENOG4108IY2 MazG family BME96_00390 ENOG41082I2 s4 domain protein BME96_00400 ENOG4105VYY sporulation protein yabp BME96_00415 ENOG41060GV RNA binding s1 domain protein BME96_00440 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) BME96_00445 ENOG4108UGV hypoxanthine phosphoribosyltransferase BME96_00450 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) BME96_00455 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) BME96_00460 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) BME96_00470 ENOG4105C6T cysteine synthase BME96_00475 ENOG4105EEI dihydropteroate synthase BME96_00480 ENOG4105KRF dihydroneopterin aldolase BME96_00485 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase BME96_00495 ENOG4105CRK lysyL-tRNA synthetase BME96_00575 ENOG4105KT7 mgtC SapB transporter BME96_00585 ENOG4108Z0C Uvrb UvrC protein BME96_00590 ENOG41066A3 ATP guanido phosphotransferase BME96_00595 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit BME96_00600 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) BME96_00605 ENOG4105CTP PilT protein domain protein BME96_00610 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) BME96_00615 ENOG4105D7W serine acetyltransferase BME96_00620 ENOG4105C8N cysteinyl-tRNA synthetase BME96_00630 ENOG4105C2N RNA methyltransferase TrmH family group 3 BME96_00635 ENOG4105M0M Tetracycline resistance protein BME96_00640 ENOG4105QIV RNA polymerase BME96_00650 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) BME96_00660 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) BME96_00665 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) BME96_00670 ENOG4108VZM 50s ribosomal protein L10 BME96_00675 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) BME96_00680 ENOG4107Y49 methyltransferase BME96_00685 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) BME96_00690 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) BME96_00695 ENOG4105XPM ribosomal protein BME96_00700 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) BME96_00705 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) BME96_00710 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) BME96_00715 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) BME96_00720 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) BME96_00725 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) BME96_00730 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) BME96_00735 ENOG41080UE One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) BME96_00740 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity BME96_00745 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) BME96_00750 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) BME96_00755 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) BME96_00760 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) BME96_00765 ENOG41082SA 50s ribosomal protein l29 BME96_00770 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal BME96_00775 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) BME96_00780 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) BME96_00785 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits BME96_00790 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) BME96_00795 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) BME96_00800 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) BME96_00805 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) BME96_00810 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) BME96_00815 ENOG4105VPB 50S ribosomal protein L30 BME96_00820 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) BME96_00825 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) BME96_00830 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) BME96_00840 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) BME96_00845 ENOG41067V7 50S ribosomal protein L36 BME96_00850 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits BME96_00855 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) BME96_00860 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) BME96_00865 ENOG4108ZT0 50S ribosomal protein l17 BME96_00870 ENOG4108JJB ABC transporter BME96_00875 ENOG4108JJB ABC transporter BME96_00880 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) BME96_00885 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) BME96_00890 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) BME96_00895 ENOG4108UJD 30S ribosomal protein S9 BME96_00970 ENOG41067MG lrgb family BME96_00980 ENOG4105CMU LysR family (Transcriptional regulator BME96_00985 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) BME96_01000 ENOG4105EYF MMPL domain protein BME96_01005 ENOG4105GMT ATPase associated with various cellular activities aaa_5 BME96_01010 ENOG4107T89 von Willebrand factor, type A BME96_01030 ENOG4107U9T Pfam:Ribonuclease_BN BME96_01060 ENOG4105D1F ATP-binding protein BME96_01075 ENOG4108NMV polysaccharide deacetylase BME96_01130 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) BME96_01135 ENOG4105NAE bifunctional deaminase-reductase domain protein BME96_01210 ENOG4105EMN RNA polymerase sigma factor BME96_01215 ENOG4105KXB anti-sigma factor BME96_01220 ENOG4105C8B TIGR00159 family BME96_01225 ENOG4107U5W ybbr family BME96_01230 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) BME96_01240 ENOG4105EFI regulatoR BME96_01245 ENOG4105BZU Histidine kinase BME96_01250 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) BME96_01275 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) BME96_01280 ENOG4108A04 Beta-lactamase BME96_01285 ENOG4105I3N Conserved Protein BME96_01290 ENOG4105C5H ABC transporter BME96_01330 ENOG4108JJ9 ABC, transporter BME96_01335 ENOG4108JJ8 (ABC) transporter BME96_01350 ENOG4105CIG ABC transporter BME96_01370 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) BME96_01410 ENOG4105WH1 Two component transcriptional regulator luxr family BME96_01420 ENOG4105BZU Histidine kinase BME96_01430 ENOG4105EWI Short-chain dehydrogenase reductase Sdr BME96_01440 ENOG4105DRR Transcriptional regulator, GntR family BME96_01445 ENOG4105CH6 catalase BME96_01450 ENOG4105D64 Mechanosensitive ion channel BME96_01470 ENOG4108S4H thioesterase Superfamily protein BME96_01485 ENOG4105DR4 Methyltransferase BME96_01490 ENOG4105DBV ornithine carbamoyltransferase BME96_01495 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) BME96_01500 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) BME96_01505 ENOG4105D6E homoserine dehydrogenase BME96_01525 ENOG4108SUT Major Facilitator Superfamily BME96_01530 ENOG4108NGU Transcriptional regulator BME96_01570 ENOG4105HMI Membrane BME96_01580 ENOG4107TXC Transcriptional regulator BME96_01585 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) BME96_01590 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase BME96_01605 ENOG4105E2A Dehydrogenase BME96_01625 ENOG4108IA2 Sodium pantothenate symporter BME96_01635 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) BME96_01645 ENOG4105C94 Transporter BME96_01680 ENOG4105CGK Exodeoxyribonuclease III BME96_01685 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family BME96_01690 ENOG4105CJ1 ABC, transporter BME96_01705 ENOG4105XXY Thioredoxin BME96_01725 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) BME96_01730 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) BME96_01740 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) BME96_01745 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) BME96_01750 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase BME96_01755 ENOG4105DK0 Indole-3-glycerol phosphate synthase BME96_01760 ENOG4108I0Q anthranilate phosphoribosyltransferase BME96_01765 ENOG4105DDQ anthranilate synthase BME96_01770 ENOG4105CRQ synthase (Component I) BME96_01775 ENOG4105CPF Cell wall formation (By similarity) BME96_01780 ENOG4105BZG amino acid carrier protein BME96_01785 ENOG4107Y03 Nitroreductase BME96_01810 ENOG4108VXD carboxy-peptidase BME96_01815 ENOG4105C2C drug resistance transporter, Bcr CflA BME96_01820 ENOG4108J59 Extracellular solute-binding protein, family 5 BME96_01825 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) BME96_01835 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) BME96_01840 ENOG4105KHC sulfurtransferase BME96_01845 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) BME96_01850 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) BME96_01860 ENOG4105C8Q Methyl-accepting chemotaxis BME96_01890 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) BME96_01895 ENOG4105NRR Uncharacterized protein conserved in bacteria (DUF2188) BME96_01905 ENOG4107ZXU DSBA oxidoreductase BME96_01910 ENOG4105DHS permease protein BME96_01915 ENOG4105CM4 permease protein BME96_01920 ENOG4108IPW abc transporter atp-binding protein BME96_01930 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) BME96_01935 ENOG4105CIH Imidazole acetol-phosphate transaminase BME96_01940 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase BME96_01945 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) BME96_01950 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase BME96_01955 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) BME96_01960 ENOG4105ECC imidazole-glycerol-phosphate dehydratase BME96_01965 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) BME96_01970 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) BME96_01975 ENOG4108IQ6 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) BME96_01980 ENOG4107RVV histidinol phosphate phosphatase, hisj family BME96_01985 ENOG4105WD1 Membrane BME96_01995 ENOG4105D4A Cell wall formation (By similarity) BME96_02010 ENOG4105E5Q amino acid AbC transporter BME96_02020 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) BME96_02025 ENOG4105EE0 oxidoreductase BME96_02035 ENOG4108Y1J Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) BME96_02040 ENOG4105SXS Protein of unknown function (DUF456) BME96_02045 ENOG4105DWF phosphomethylpyrimidine kinase BME96_02060 ENOG4107R1M Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) (By similarity) BME96_02070 ENOG4108HW3 (ABC) transporter BME96_02075 ENOG4105E5Q amino acid AbC transporter BME96_02080 ENOG4105CDA abc transporter atp-binding protein BME96_02085 ENOG4105C7R Atpase associated with various cellular activities aaa_3 BME96_02090 ENOG4108V06 Glutathione peroxidase BME96_02095 ENOG4108K88 Membrane BME96_02100 ENOG4108K8K Transcriptional regulator BME96_02105 ENOG4105DCF alanine dehydrogenase BME96_02110 ENOG4105C72 UPF0176 protein BME96_02125 ENOG4105VEQ Cold shock protein BME96_02130 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) BME96_02140 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase BME96_02155 ENOG4105VES Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082) BME96_02160 ENOG4105C0H protease BME96_02170 ENOG41062D9 Histidine kinase BME96_02175 ENOG4105CI3 gtp-binding protein typa BME96_02180 ENOG4105C5Y PTS System BME96_02185 ENOG4105CG3 alpha amylase, catalytic region BME96_02190 ENOG4107414 GntR family transcriptional regulator BME96_02195 ENOG4107TUM Amidinotransferase BME96_02205 ENOG4108TU7 Inherit from COG: (ABC) transporter BME96_02210 ENOG4105CJ1 ABC, transporter BME96_02220 ENOG4105DQ6 Transposase BME96_02225 ENOG4105CHU acetyl-coa acetyltransferase BME96_02235 ENOG4105PNM synthesis protein BME96_02245 ENOG4105SZ6 Thioredoxin BME96_02255 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BME96_02260 ENOG41062D9 Histidine kinase BME96_02270 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) BME96_02275 ENOG41090MY MarR family Transcriptional regulator BME96_02280 ENOG4105CGD Nad-dependent epimerase dehydratase BME96_02300 ENOG4105EPR degv family BME96_02305 ENOG4108TVT permease BME96_02310 ENOG4105C1J atp-dependent rna helicase BME96_02320 ENOG41082V8 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) BME96_02325 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) BME96_02330 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein BME96_02335 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) BME96_02345 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) BME96_02350 ENOG4107MMM Anti-sigma-factor antagonist BME96_02355 ENOG4105FUA antagonist BME96_02360 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase BME96_02365 ENOG4107SGM protein serine threonine phosphatase BME96_02370 ENOG4105WN5 stage II sporulation protein BME96_02375 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) BME96_02385 ENOG41064BQ Phosphatase BME96_02395 ENOG4105CH6 catalase BME96_02400 ENOG410906U SprT-like BME96_02490 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) BME96_02495 ENOG4105K8N protein family UPF0079, ATPase BME96_02500 ENOG41072GX Peptidase M22 Glycoprotease BME96_02505 ENOG410801F ribosomal-protein-alanine acetyltransferase BME96_02510 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) BME96_02520 ENOG4105C5H ABC transporter BME96_02530 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) BME96_02540 ENOG4108TYN CAAX amino terminal protease family protein BME96_02545 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) BME96_02550 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) BME96_02565 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) BME96_02570 ENOG41090E6 transcriptional regulator MERR family BME96_02580 ENOG4108RZE Tetr family transcriptional regulator BME96_02585 ENOG4105C94 Transporter BME96_02590 ENOG4105C4B ABC transporter, permease BME96_02595 ENOG4108IXI (ABC) transporter BME96_02625 ENOG4107Z3H Transcriptional regulator, TetR family BME96_02635 ENOG4105D8X mechanosensitive ion channel BME96_02655 ENOG4108NHD germination protein BME96_02665 ENOG4105CFC Transporter BME96_02685 ENOG4105QVS general stress protein BME96_02690 ENOG4105C7R Atpase associated with various cellular activities aaa_3 BME96_02705 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) BME96_02710 ENOG4105C7N Xanthine uracil vitamin C permease BME96_02720 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) BME96_02725 ENOG4108RPX mosc domain containing protein BME96_02735 ENOG4108U5N UPF0316 protein BME96_02740 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) BME96_02745 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) BME96_02750 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit BME96_02755 ENOG4105C83 adenylosuccinate lyase BME96_02760 ENOG4105C8V SAICAR synthetase BME96_02765 ENOG4105VR9 phosphoribosylformylglycinamidine synthase BME96_02770 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I BME96_02775 ENOG4107QIK phosphoribosylformylglycinamidine synthase BME96_02785 ENOG4105CXB phosphoribosylaminoimidazole synthetase BME96_02790 ENOG4108V3E phosphoribosylglycinamide formyltransferase BME96_02795 ENOG4105DC1 bifunctional purine biosynthesis protein purh BME96_02800 ENOG4105C12 Phosphoribosylglycinamide synthetase BME96_02805 ENOG4105CPN adenine deaminase BME96_02810 ENOG4108R5T secreted protein BME96_02815 ENOG4105KGF protein, YerC YecD BME96_02820 ENOG4108RE7 deoxyribonuclease BME96_02825 ENOG4108RTE 35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales (By similarity) BME96_02830 ENOG4105C4R Atp-dependent dna helicase BME96_02835 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) BME96_02845 ENOG4105C26 Dehydrogenase BME96_02855 ENOG4105CK7 Sodium proline symporter BME96_02860 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) BME96_02865 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) BME96_02870 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) BME96_02875 ENOG4105CBD Diacylglycerol kinase BME96_02880 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) BME96_02885 ENOG4107PP3 Acetylornithine deacetylase BME96_02890 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) BME96_02915 ENOG41060D1 Quinol oxidase BME96_02925 ENOG4105BZ9 Cytochrome C oxidase, subunit I BME96_02935 ENOG4105BZ4 penicillin-binding protein BME96_02940 ENOG4105VEQ Cold shock protein BME96_02945 ENOG4107Y9U Membrane BME96_02955 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) BME96_02975 ENOG4108RCM Nitroreductase BME96_02980 ENOG4105C34 Pseudouridine synthase BME96_02990 ENOG4105G6Z alkaline phosphatase BME96_02995 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BME96_03000 ENOG4105C5H ABC transporter BME96_03030 ENOG4105C8J )-transporter BME96_03035 ENOG4107S6Z Na H antiporter BME96_03040 ENOG4105CHM Aminotransferase BME96_03045 ENOG4105C7K acetolactate synthase BME96_03050 ENOG4105C26 Dehydrogenase BME96_03060 ENOG4107258 Transcriptional regulator BME96_03070 ENOG4105C26 Dehydrogenase BME96_03080 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F BME96_03090 ENOG4105K4I Scp-like extracellular BME96_03095 ENOG4105CSV Glutaminase BME96_03100 ENOG4108RAV Conserved protein BME96_03105 ENOG4105BZG amino acid carrier protein BME96_03115 ENOG4107U9T Pfam:Ribonuclease_BN BME96_03120 ENOG4105C59 p-type ATPase BME96_03125 ENOG4108ISG Major Facilitator BME96_03150 ENOG4105BZU Histidine kinase BME96_03160 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) BME96_03170 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 BME96_03175 ENOG41073TP transcriptional regulator BME96_03180 ENOG4105DVE abc transporter atp-binding protein BME96_03195 ENOG4105DA5 (ABC) transporter BME96_03200 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) BME96_03210 ENOG4105FDP GntR family transcriptional regulator BME96_03230 ENOG4105ECP epimerase BME96_03235 ENOG410902V Modulates RecA activity (By similarity) BME96_03250 ENOG41067AE Membrane-bound metal-dependent hydrolase BME96_03255 ENOG4105CEN a g-specific adenine glycosylase BME96_03265 ENOG4105EVI UPF0374 protein BME96_03270 ENOG4105BZ1 (ABC) transporter BME96_03275 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase BME96_03285 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BME96_03290 ENOG4105D3Q Sugar transferase BME96_03295 ENOG4105C5I Dehydrogenase BME96_03300 ENOG4105G5W regulator Fur family BME96_03305 ENOG4105CRQ synthase (Component I) BME96_03310 ENOG4105DDQ anthranilate synthase BME96_03315 ENOG4105TUA UPF0295 protein BME96_03420 ENOG4105DMC D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 BME96_03430 ENOG4105EYF MMPL domain protein BME96_03440 ENOG4108Z03 MAF-like protein BME96_03450 ENOG4105KVH Transcriptional regulator BME96_03460 ENOG4107V0Z fmn reductase BME96_03465 ENOG4105C84 Histidine ammonia-lyase BME96_03480 ENOG4107VFR oxidoreductase BME96_03490 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase BME96_03505 ENOG410742N Small acid-soluble spore protein P family BME96_03515 ENOG4108UKS UPF0398 protein BME96_03545 ENOG4108W0I acetyltransferase BME96_03570 ENOG4107SVH Potassium channel protein BME96_03740 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) BME96_03745 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) BME96_03750 ENOG4108Z7R Chaperone CsaA BME96_03760 ENOG41068KF Universal stress protein BME96_03765 ENOG4108J59 Extracellular solute-binding protein, family 5 BME96_03770 ENOG4105CQB FAD linked oxidase domain protein BME96_03785 ENOG4105CM2 brancheD-chain amino acid aminotransferase BME96_03790 ENOG4105U0R haloacid dehalogenase-like hydrolase BME96_03795 ENOG4108JQ1 Dehydrogenase BME96_03830 ENOG41085PJ rdd domain containing protein BME96_03835 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) BME96_03840 ENOG4105D07 Signal peptide peptidase, SppA BME96_03845 ENOG4105VK3 rdd domain containing protein BME96_03850 ENOG4105CEY Amp-dependent synthetase and ligase BME96_03860 ENOG4106DDH Sporulation-specific SASP protein BME96_03880 ENOG4105C2W permease BME96_03905 ENOG4105CIS alcohol dehydrogenase BME96_03915 ENOG4107P5I polyketide synthase BME96_03940 ENOG4106DF1 BME96_03950 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase BME96_03955 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) BME96_03960 ENOG4105CAS nag kinase BME96_03965 ENOG4105C8Y Acetylornithine aminotransferase BME96_03970 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain BME96_03975 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein BME96_03980 ENOG4105CAT Cytidine monophosphate kinase BME96_03990 ENOG4107RU9 Transcriptional regulator, Crp Fnr family BME96_04005 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) BME96_04010 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) BME96_04025 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 BME96_04030 ENOG4105C7S Dehydrogenase BME96_04035 ENOG4105D9N nucleoside BME96_04045 ENOG4107QMU Mate efflux family protein BME96_04050 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) BME96_04060 ENOG4108B31 Spore germination protein BME96_04070 ENOG4108V2W Carbonate dehydratase BME96_04080 ENOG4105BZ1 (ABC) transporter BME96_04085 ENOG4105BZ1 (ABC) transporter BME96_04090 ENOG4105C0H protease BME96_04105 ENOG4108WZW RNA polymerase sigma BME96_04125 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) BME96_04135 ENOG4105C28 cystathionine BME96_04140 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) BME96_04145 ENOG410904N short-chain dehydrogenase reductase BME96_04155 ENOG4105CJ1 ABC, transporter BME96_04160 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) BME96_04170 ENOG4105DFD Na H antiporter BME96_04175 ENOG4108UMN azlc family BME96_04195 ENOG4105DEU major facilitator superfamily BME96_04205 ENOG4105C9Q fumarate hydratase class II BME96_04225 ENOG4105WZB UPF0342 protein BME96_04230 ENOG4105CGU Enoyl-CoA hydratase BME96_04240 ENOG4108IUX (ABC) transporter BME96_04245 ENOG4105RHA ABC transporter, permease BME96_04250 ENOG4107VRP DNA repair exonuclease BME96_04255 ENOG4106D4I domain protein BME96_04260 ENOG4105TRT Transcriptional regulator BME96_04265 ENOG4105EQI Metal Dependent Phosphohydrolase BME96_04275 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) BME96_04295 ENOG4107HG4 Transcriptional regulator BME96_04325 ENOG4105NBU tryptophan transport protein BME96_04330 ENOG4105K59 histidine triad (HIT) protein BME96_04350 ENOG4108UQY Iron-storage protein BME96_04360 ENOG4107Y80 Major Facilitator superfamily BME96_04370 ENOG4105ENE Histidine kinase BME96_04375 ENOG4105WH1 Two component transcriptional regulator luxr family BME96_04380 ENOG4105DQ6 Transposase BME96_04395 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation BME96_04400 ENOG4105BZ4 penicillin-binding protein BME96_04405 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) BME96_04410 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) BME96_04415 ENOG4105C1Q protoporphyrinogen oxidase BME96_04420 ENOG4105DPN Oligoendopeptidase f BME96_04435 ENOG4108RQ5 Beta-lactamase domain-containing protein BME96_04440 ENOG4105DF9 Lipoate-protein, ligase BME96_04445 ENOG4105CEY Amp-dependent synthetase and ligase BME96_04465 ENOG4105C5N The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination BME96_04470 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation BME96_04475 ENOG4105NAA Cytochrome C oxidase, subunit II BME96_04480 ENOG4107RQ2 Cytochrome c oxidase, subunit I BME96_04530 ENOG4105C8Y Acetylornithine aminotransferase BME96_04535 ENOG4105YHS UPF0344 protein BME96_04560 ENOG4105EPR degv family BME96_04565 ENOG4107AYK membrAne BME96_04585 ENOG4108KP7 hydrolase BME96_04590 ENOG4108MXZ Esterase BME96_04595 ENOG4105VG1 fes assembly suf system protein BME96_04605 ENOG4108ZAF Molybdopterin BME96_04615 ENOG4105VG1 fes assembly suf system protein BME96_04650 ENOG4107V6Q Cyclic nucleotide-binding domain BME96_04655 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) BME96_04675 ENOG4107RMD Basic membrane lipoprotein BME96_04680 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) BME96_04685 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) BME96_04695 ENOG4108KU1 UPF0736 protein BME96_04700 ENOG4105C31 Tryptophanyl-tRNA synthetase BME96_04715 ENOG41090UD (LipO)protein BME96_04730 ENOG4105NQN cytochrome C BME96_04735 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) BME96_04740 ENOG4108SQ7 Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis BME96_04750 ENOG4105DPN Oligoendopeptidase f BME96_04755 ENOG4105T58 Dithiol-disulfide isomerase BME96_04760 ENOG4108Z18 K06886 hemoglobin BME96_04765 ENOG4105MIX Adenylate cyclase BME96_04775 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) BME96_04780 ENOG4105EMS pseudouridine synthase BME96_04785 ENOG4107S1Q Phosphatase BME96_04790 ENOG4105CJW magnesium transporter BME96_04820 ENOG4105H67 Protein of unknown function (DUF421) BME96_04830 ENOG4108ZMI UPF0477 protein BME96_04840 ENOG4105BZ1 (ABC) transporter BME96_04845 ENOG4105BZ1 (ABC) transporter BME96_04855 ENOG4105CH6 catalase BME96_04895 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) BME96_04900 ENOG4108UMI ABC transporter, permease BME96_04905 ENOG4105D01 (LipO)protein BME96_04935 ENOG4108QXE glycerophosphoryl diester phosphodiesterase BME96_04965 ENOG4106FGC BME96_04975 ENOG4105ER2 Ompa motb domain protein BME96_04990 ENOG4105C5H ABC transporter BME96_05010 ENOG4108QXE glycerophosphoryl diester phosphodiesterase BME96_05015 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein BME96_05025 ENOG4108HK0 -acetyltransferase BME96_05040 ENOG4107SCK Monooxygenase BME96_05055 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) BME96_05060 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) BME96_05070 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) BME96_05075 ENOG4105E1K spore germination protein BME96_05115 ENOG4105DWT malate dehydrogenase (quinone) BME96_05145 ENOG4105D7V transposase BME96_05175 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BME96_05200 ENOG4108RPX mosc domain containing protein BME96_05220 ENOG4107T5V SNARE associated Golgi BME96_05230 ENOG4105HHM rdd domain containing protein BME96_05245 ENOG4105EV9 Alpha Beta Hydrolase BME96_05250 ENOG4105KNA -acetyltransferase BME96_05265 ENOG4105D7V transposase BME96_05310 ENOG4107Y9E nuclease BME96_05320 ENOG4108VK3 Cupin 2 Conserved Barrel Domain Protein BME96_05330 ENOG4105RHY Pfam:UPF0157 BME96_05385 ENOG4105DVE abc transporter atp-binding protein BME96_05395 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) BME96_05400 ENOG4105EHG Permease protein BME96_05405 ENOG4105E0A ABC, transporter BME96_05410 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) BME96_05415 ENOG4105CIH Imidazole acetol-phosphate transaminase BME96_05425 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) BME96_05430 ENOG4107XPA Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) BME96_05435 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) BME96_05445 ENOG4108WBT adenosyltransferase BME96_05460 ENOG4105IIP Membrane BME96_05485 ENOG4105DTQ mandelate racemase muconate lactonizing BME96_05500 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving BME96_05515 ENOG4105C0R drug resistance transporter emrb qaca subfamily BME96_05555 ENOG4105K59 histidine triad (HIT) protein BME96_05605 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) BME96_05625 ENOG4105E09 nadh pyrophosphatase BME96_05675 ENOG4105M4B Catalyzes the transfer of an acetyl group from acetyl- CoA to the 6'-amino group of aminoglycoside molecules conferring resistance to antibiotics containing the purpurosamine ring (By similarity) BME96_05715 ENOG4107RA9 decarboxylase BME96_05720 ENOG41090HR transcriptional regulator BME96_05735 ENOG4105HRU Glyoxalase Bleomycin resistance protein (Dioxygenase BME96_05775 ENOG4108Z5V transcriptional regulator, merr family BME96_05785 ENOG4105IIP Membrane BME96_05800 ENOG4108I0C methyltransferase BME96_05810 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) BME96_05840 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BME96_05880 ENOG4108YYC ycei family BME96_05890 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase BME96_05900 ENOG41090MY MarR family Transcriptional regulator BME96_05905 ENOG4108F19 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) BME96_05950 ENOG4105NA0 Transcriptional regulator BME96_05970 ENOG4105WCN acetyltransferase BME96_05980 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) BME96_05985 ENOG4105CMT Dihydroxyacetone kinase BME96_05990 ENOG4108UTZ Dihydroxyacetone kinase BME96_06035 ENOG4105DY9 regulatoR BME96_06040 ENOG4108UW5 maltose o-acetyltransferase BME96_06045 ENOG4105K7K Transcriptional regulator BME96_06070 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) BME96_06075 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) BME96_06085 ENOG4105DQW permease for cytosine purines, uracil, thiamine, allantoin BME96_06095 ENOG4105CFG Acts as a chaperone (By similarity) BME96_06110 ENOG4105CRW Short chain fatty acid transporter BME96_06120 ENOG4105CJ1 ABC, transporter BME96_06175 ENOG4107QRT dEAD DEAH box helicase BME96_06180 ENOG4108HFV BME96_06185 ENOG4105M6F mutator MutT protein BME96_06195 ENOG4105CFI type iii restriction protein res subunit BME96_06235 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) BME96_06250 ENOG4105GIG BME96_06340 ENOG4105VMP Transcriptional regulator BME96_06345 ENOG4105NX3 Membrane BME96_06375 ENOG4105CVJ phosphoglycerate mutase BME96_06380 ENOG4105KCT ABC transporter BME96_06385 ENOG4108M15 ABC transporter BME96_06390 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A BME96_06395 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) BME96_06430 ENOG4105WYW fructose-bisphosphate aldolase BME96_06435 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein BME96_06440 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase BME96_06445 ENOG4107SDU Methyl-accepting chemotaxis BME96_06450 ENOG4105VEM Conserved domain protein BME96_06490 ENOG41060GV RNA binding s1 domain protein BME96_06500 ENOG4105C26 Dehydrogenase BME96_06510 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) BME96_06515 ENOG4106IPI cyclase, family BME96_06525 ENOG4105C8J )-transporter BME96_06530 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BME96_06575 ENOG4105RHY Pfam:UPF0157 BME96_06595 ENOG4105WDR BME96_06600 ENOG4105CPC Aldo Keto reductase BME96_06610 ENOG4108SJC Membrane BME96_06615 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) BME96_06625 ENOG4108MUZ hydrolase BME96_06660 ENOG4105C94 Transporter BME96_06665 ENOG41067SE Tetr family transcriptional regulator BME96_06670 ENOG4105C0R drug resistance transporter emrb qaca subfamily BME96_06690 ENOG4105E4C Lytic transglycosylase catalytic BME96_06695 ENOG4108QY0 Membrane BME96_06710 ENOG4105D7V transposase BME96_06730 ENOG4105E2A Dehydrogenase BME96_06775 ENOG4106X9J Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) BME96_06780 ENOG4107THD Involved in phosphonate degradation (By similarity) BME96_06785 ENOG4105E0M Sulfatase BME96_06790 ENOG41082YX Transcriptional regulator, arsr family BME96_06795 ENOG4107R5R arsenical pump membrane protein BME96_06800 ENOG4108UXE Protein tyrosine phosphatase BME96_06810 ENOG4105F1A Pyruvate formate-lyase BME96_06835 ENOG4105D7N magnesium and cobalt transport protein CorA BME96_06845 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) BME96_06850 ENOG4108R6K riboflavin synthase, subunit alpha BME96_06855 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) BME96_06860 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) BME96_06880 ENOG4105S2F BME96_06890 ENOG4107ZQN disulfide bond BME96_06920 ENOG4105BZU Histidine kinase BME96_06925 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BME96_06935 ENOG4107R16 Multicopper oxidase BME96_06940 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) BME96_06945 ENOG41068WN BME96_06950 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase BME96_06965 ENOG4105F6S Spore photoproduct lyase BME96_06980 ENOG4105MRC Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth BME96_07010 ENOG4107ETC gas vesicle protein BME96_07015 ENOG4108XNA Gas vesicle BME96_07020 ENOG4105W2E Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth (By similarity) BME96_07050 ENOG4105VT3 DNA binding domain protein, excisionase family BME96_07055 ENOG4105CHH sulfate transporter BME96_07080 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation BME96_07085 ENOG4105BZU Histidine kinase BME96_07105 ENOG4105CI2 imidazolone-5-propionate hydrolase BME96_07110 ENOG4105FEU K -dependent Na -Ca exchanger BME96_07115 ENOG4105YB8 TM2 domain containing protein BME96_07120 ENOG4105DJZ UPF0182 protein BME96_07155 ENOG4105DUX Transporter BME96_07190 ENOG41080XP Cbs domain BME96_07210 ENOG4107QV7 Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) BME96_07220 ENOG4105CBX hi0933 family BME96_07235 ENOG4107F58 2'-5' rna ligase BME96_07245 ENOG4108V15 phosphotransferase enzyme family BME96_07255 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) BME96_07260 ENOG4105C8F Beta-lactamase domain protein BME96_07275 ENOG4108K16 Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) BME96_07280 ENOG4108V0E nucleoside 2-deoxyribosyltransferase YtoQ BME96_07290 ENOG4108NKM UPF0354 protein BME96_07295 ENOG4108VDD TRNA binding domain protein BME96_07310 ENOG4105DFU Cell wall formation (By similarity) BME96_07325 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase BME96_07330 ENOG4105ETE Transcriptional regulator (LacI family BME96_07335 ENOG4105E14 MotA TolQ exbB proton channel BME96_07340 ENOG4106VK6 Flagellar motor protein BME96_07345 ENOG4105DGU Histone deacetylase BME96_07350 ENOG4105W87 Cbs domain BME96_07355 ENOG4105F1V Acetoin utilization protein BME96_07360 ENOG4105BZ4 penicillin-binding protein BME96_07365 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) BME96_07370 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) BME96_07375 ENOG4105BZU Histidine kinase BME96_07385 ENOG4105U5Y Transcriptional regulator BME96_07390 ENOG4105DGY modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization (By similarity) BME96_07400 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) BME96_07410 ENOG4108KKH Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) BME96_07420 ENOG4105KBJ sporulation protein ytfj BME96_07425 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) BME96_07435 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) BME96_07440 ENOG4105EPU Molybdenum cofactor synthesis domain protein BME96_07445 ENOG4107YZX Universal stress protein BME96_07455 ENOG41087YS Phage shock protein A BME96_07470 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) BME96_07475 ENOG4105E8R UPF0173 metal-dependent hydrolase BME96_07495 ENOG4107QHF type ii secretion system protein e BME96_07500 ENOG4105CZX twitching motility protein BME96_07505 ENOG4105D7Q type ii secretion system BME96_07515 ENOG4106A3R peptidase BME96_07550 ENOG4105SFS phosphoesterase RecJ domain protein BME96_07565 ENOG4105VV2 BME96_07570 ENOG4105C0B DNA polymerase III (alpha subunit) BME96_07575 ENOG4105C6K Malic enzyme BME96_07580 ENOG41073TP transcriptional regulator BME96_07585 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) BME96_07590 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) BME96_07595 ENOG4105CTQ phosphohexokinase BME96_07600 ENOG4105CA9 Pyruvate kinase BME96_07605 ENOG4105FS0 cytoplasmic membrane protein BME96_07610 ENOG4108REF Sporulation integral membrane protein ytvi BME96_07615 ENOG4105BZN citrate synthase BME96_07620 ENOG4108HMX isocitrate dehydrogenase (NADP) BME96_07625 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) BME96_07635 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BME96_07640 ENOG4105BZU Histidine kinase BME96_07645 ENOG4105C2M dna polymerase I BME96_07650 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) BME96_07655 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) BME96_07660 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase BME96_07665 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) BME96_07675 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) BME96_07690 ENOG4108TDW sporulation protein YtxC BME96_07695 ENOG4105C22 threonyL-tRNA synthetase BME96_07700 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) BME96_07705 ENOG4105VJV 50s ribosomal protein L35 BME96_07710 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) BME96_07715 ENOG410696E Membrane BME96_07735 ENOG4105CN9 Peptidase m42 family protein BME96_07740 ENOG4105E4C Lytic transglycosylase catalytic BME96_07745 ENOG4105CJ1 ABC, transporter BME96_07765 ENOG41067MF small acid-soluble spore protein BME96_07770 ENOG4108RWN rrna methyltransferase BME96_07775 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) BME96_07780 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) BME96_07785 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) BME96_07790 ENOG410687F Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) BME96_07800 ENOG4105DCG PHP domain protein BME96_07805 ENOG4105C98 muts2 protein BME96_07815 ENOG4105CEY Amp-dependent synthetase and ligase BME96_07820 ENOG4107Z3H Transcriptional regulator, TetR family BME96_07825 ENOG41060WC Enoyl-CoA hydratase BME96_07830 ENOG4105BZJ Electron transfer flavoprotein BME96_07835 ENOG4105C10 Electron transfer flavoprotein BME96_07840 ENOG4105K63 Thioredoxin BME96_07845 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) BME96_07855 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit BME96_07865 ENOG4105E33 succinate dehydrogenase BME96_07875 ENOG4105PFC Transcriptional regulator BME96_07880 ENOG41067TZ transcriptional regulator, MarR family BME96_07885 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) BME96_07890 ENOG4108XJQ germination protein BME96_07895 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) BME96_07900 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) BME96_07905 ENOG4105M59 Phosphodiesterase, mj0936 family BME96_07930 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation BME96_07935 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) BME96_07945 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) BME96_07955 ENOG4105E5Q amino acid AbC transporter BME96_07970 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) BME96_07980 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) BME96_07990 ENOG4105D52 delta-aminolevulinic acid dehydratase BME96_07995 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase BME96_08000 ENOG41068KH stage VI sporulation protein D BME96_08000 ENOG41068KH stage VI sporulation protein D BME96_08015 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) BME96_08025 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) BME96_08030 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase BME96_08040 ENOG4105W5Q DNA repair protein (RadC BME96_08045 ENOG4108FPN Integrase BME96_08050 ENOG4108KU9 integrase family BME96_08055 ENOG4105ZX1 Transposase C BME96_08070 ENOG4105DFF Rod shape-determining protein mreb BME96_08075 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) BME96_08085 ENOG4107YDG Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) BME96_08090 ENOG4107QMS site-determining protein BME96_08105 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) BME96_08110 ENOG4105X36 (ribosomal) protein BME96_08115 ENOG4105K46 50S ribosomal protein l27 BME96_08125 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control BME96_08130 ENOG4105CQC Prephenate dehydratase BME96_08135 ENOG4106678 morphogenetic protein associated with SpoVID BME96_08145 ENOG4107RA1 nh(3)-dependent nad( ) synthetase BME96_08155 ENOG4105CDY transcriptional regulatory protein BME96_08160 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) BME96_08165 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) BME96_08175 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) BME96_08180 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) BME96_08185 ENOG4105VIE preprotein translocase, subunit YajC BME96_08190 ENOG4105NAP BME96_08195 ENOG4107R3E Citrate transporter BME96_08205 ENOG4105CKP Polysaccharide Biosynthesis Protein BME96_08215 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) BME96_08220 ENOG41067VP Protein of unknown function (DUF1049) BME96_08225 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) BME96_08230 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) BME96_08235 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) BME96_08240 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) BME96_08245 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase BME96_08250 ENOG4105CUT histidyl-tRNA synthetase BME96_08255 ENOG4105C9M aspartyl-trna synthetase BME96_08265 ENOG4108VCI transcription factor, rsfa family BME96_08270 ENOG4105D1H recombination factor protein RarA BME96_08280 ENOG4105C3J Cysteine desulfurase BME96_08285 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) BME96_08295 ENOG4105C7H Helicase, RecD TraA family BME96_08300 ENOG41060CR BME96_08305 ENOG4105C02 permease BME96_08310 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) BME96_08315 ENOG4105VBH UPF0297 protein BME96_08320 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) BME96_08330 ENOG4105HHA aminodeoxychorismate lyase BME96_08335 ENOG4108VQJ O-methyltransferase BME96_08340 ENOG4105DBI uridine monophosphokinase BME96_08345 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) BME96_08355 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) BME96_08365 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BME96_08370 ENOG4105KJM monovalent cation h antiporter subunit g BME96_08380 ENOG4105SC1 monovalent cation H antiporter subunit E BME96_08385 ENOG4108JPZ Monovalent cation H antiporter subunit D BME96_08390 ENOG4105MKQ Monovalent cation H antiporter subunit C BME96_08395 ENOG4105D65 subunit l BME96_08405 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase BME96_08410 ENOG4105CQW ribosome biogenesis GTPase YqeH BME96_08415 ENOG4105E2X shikimate dehydrogenase BME96_08420 ENOG410812S Rna-binding protein BME96_08425 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) BME96_08430 ENOG4108WF2 Metal Dependent Phosphohydrolase BME96_08440 ENOG4105DXX methyltransferase BME96_08445 ENOG4105KQC Competence protein BME96_08450 ENOG4108UK2 deaminase BME96_08455 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 BME96_08460 ENOG4105TQK DNA polymerase iii, delta' subunit BME96_08465 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) BME96_08470 ENOG4105CEF Initiates the rapid degradation of small, acid-soluble proteins during spore germination (By similarity) BME96_08475 ENOG4108ZRV stage ii sporulation protein p BME96_08485 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) BME96_08490 ENOG4105CSA Coproporphyrinogen iii oxidase BME96_08495 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) BME96_08500 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ BME96_08505 ENOG4105CFG Acts as a chaperone (By similarity) BME96_08510 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) BME96_08515 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) BME96_08520 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) BME96_08525 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) BME96_08530 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) BME96_08535 ENOG4105VCC 30S ribosomal protein S21 BME96_08540 ENOG4105KTH gatB Yqey BME96_08545 ENOG4105F7J membrane-bound serine protease BME96_08550 ENOG4105DI5 UPF0365 protein BME96_08560 ENOG41068P3 sporulation protein YqfC BME96_08570 ENOG4105C9A Phoh family BME96_08575 ENOG4105CTJ Metal Dependent Phosphohydrolase BME96_08580 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) BME96_08590 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) BME96_08595 ENOG4108SAY Involved in DNA repair and RecF pathway recombination (By similarity) BME96_08600 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit BME96_08605 ENOG4105C38 Glycyl-tRNA synthetase beta subunit BME96_08615 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) BME96_08620 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) BME96_08625 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BME96_08645 ENOG4105EGD dinuclear metal center protein, YbgI family BME96_08655 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) BME96_08665 ENOG41063Y9 BME96_08680 ENOG4108UTW Plays a role in the regulation of phosphate uptake BME96_08725 ENOG4107RF6 penicillin-binding protein BME96_08730 ENOG41068DG YceG-like family BME96_08740 ENOG4105WDJ 50S ribosomal protein L33 BME96_08745 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase BME96_08750 ENOG4105D06 uba thif-type nad fad binding protein BME96_08760 ENOG4107ZXI Rhomboid family BME96_08780 ENOG4105DKQ ROK family BME96_08790 ENOG4105C5X domain protein BME96_08825 ENOG4106855 Competence protein BME96_08845 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) BME96_08900 ENOG4105QBX endodeoxyribonuclease RusA BME96_08925 ENOG410682Q Phage transcriptional regulator, ArpU BME96_08970 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) BME96_09105 ENOG4105C0D helicase BME96_09110 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) BME96_09115 ENOG4107QK8 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor BME96_09120 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor BME96_09125 ENOG4105WZW rhodanese family BME96_09130 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BME96_09135 ENOG4105KST dependent repressor BME96_09155 ENOG4105DC7 peptidase M24 BME96_09160 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) BME96_09165 ENOG4105CD2 stage iii sporulation protein aa BME96_09170 ENOG4105KR5 Stage iii sporulation protein BME96_09175 ENOG4108CQH stage III sporulation protein AC BME96_09180 ENOG4105KQ4 Stage iii sporulation protein ad BME96_09190 ENOG410644B Stage III sporulation protein af BME96_09210 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase BME96_09215 ENOG4108ZSR alkaline shock protein BME96_09220 ENOG4105M7K Involved in the transcription termination process (By similarity) BME96_09225 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) BME96_09230 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) BME96_09235 ENOG41084DP Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) BME96_09250 ENOG4105DX0 Hemolysin A BME96_09255 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) BME96_09260 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) BME96_09265 ENOG4105S1Z Stage IV sporulation protein B BME96_09270 ENOG4107QQR Sporulation BME96_09275 ENOG4105CFH Aspartokinase BME96_09285 ENOG4108JUB Transcriptional regulator BME96_09295 ENOG4107RDP Dehydrogenase BME96_09315 ENOG4105CPP Dehydrogenase, E1 component BME96_09320 ENOG4105C7S Dehydrogenase BME96_09325 ENOG4108Y6J UPF0403 protein BME96_09330 ENOG4108QEG Membrane BME96_09340 ENOG4108ZVT methylmalonyl-coA epimerase BME96_09345 ENOG4108HNZ carboxyl transferase BME96_09350 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) BME96_09360 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) BME96_09365 ENOG4105C26 Dehydrogenase BME96_09370 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) BME96_09375 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase BME96_09380 ENOG4108QXE glycerophosphoryl diester phosphodiesterase BME96_09390 ENOG41069FQ Metallo-beta-lactamase superfamily BME96_09395 ENOG4108IXY short-chain dehydrogenase reductase BME96_09405 ENOG4105CPC Aldo Keto reductase BME96_09420 ENOG4105MZ9 stage II sporulation protein m BME96_09425 ENOG4105I3K Ferric uptake regulator, Fur family BME96_09435 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BME96_09440 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) BME96_09455 ENOG4105DZ1 carboxypeptidase BME96_09460 ENOG41082AN stage II sporulation protein BME96_09465 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) BME96_09470 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BME96_09490 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) BME96_09495 ENOG4107ZE5 PPIases accelerate the folding of proteins BME96_09515 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) BME96_09520 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) BME96_09525 ENOG4105DZ1 carboxypeptidase BME96_09530 ENOG4108JIC nucleoside recognition domain protein BME96_09540 ENOG4105FE9 pseudouridine synthase BME96_09545 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BME96_09550 ENOG4107TWT Cytochrome c biogenesis protein BME96_09555 ENOG4105CRE cytochrome C BME96_09560 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BME96_09565 ENOG4105BZU Histidine kinase BME96_09580 ENOG4105T7X BME96_09585 ENOG4105C9U ATP-dependent DNA helicase RecQ BME96_09590 ENOG4105I7S Abortive infection protein BME96_09600 ENOG4107RGJ metallophosphoesterase BME96_09605 ENOG4108S6Z Negative regulator of genetic competence BME96_09615 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase BME96_09620 ENOG4107RB3 L-asparaginase BME96_09625 ENOG4108PNU Involved in the degradation of specific anti-sigma factors (By similarity) BME96_09630 ENOG4105F0V Cell wall hydrolase BME96_09635 ENOG4105MSI germination protein ypeb BME96_09645 ENOG4105CAT Cytidine monophosphate kinase BME96_09655 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) BME96_09665 ENOG4105S2F BME96_09670 ENOG41065D1 BME96_09675 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) BME96_09680 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase BME96_09700 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) BME96_09705 ENOG4105K70 DNA-binding protein BME96_09710 ENOG4105WP2 Tryptophan RNA-binding attenuator protein BME96_09715 ENOG4105XXQ heptaprenyl diphosphate synthase component I BME96_09720 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) BME96_09725 ENOG4105EAH synthase BME96_09730 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) BME96_09735 ENOG4105BZU Histidine kinase BME96_09740 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase BME96_09745 ENOG4105D49 3-dehydroquinate synthase BME96_09750 ENOG4105KHN chorismate mutase BME96_09755 ENOG4105CIH Imidazole acetol-phosphate transaminase BME96_09765 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase BME96_09770 ENOG41068YB TPR repeat-containing protein BME96_09775 ENOG4108SXZ UPF0302 protein BME96_09790 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) BME96_09795 ENOG4105PE6 Menaquinol-cytochrome c reductase, cytochrome b c subunit BME96_09815 ENOG4108JYZ YitT family BME96_09820 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase BME96_09825 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) BME96_09830 ENOG4108Z5K methylglyoxal synthase BME96_09835 ENOG4105CPK Glycosyl transferase (Group 1 BME96_09840 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate BME96_09855 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) BME96_09860 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) BME96_09865 ENOG4105DVT helicase BME96_09870 ENOG4105YAC BME96_09880 ENOG4105CHM Aminotransferase BME96_09885 ENOG4105C5S asparaginyl-tRNA synthetase BME96_09895 ENOG4105CSM endonuclease III BME96_09900 ENOG4105BZ4 penicillin-binding protein BME96_09905 ENOG4108UI2 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) BME96_09925 ENOG4105KG3 cytidine deaminase BME96_09930 ENOG4105XWG Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation (By similarity) BME96_09940 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) BME96_09945 ENOG4105CTD carboxy-peptidase BME96_09950 ENOG41065KQ synthase BME96_09960 ENOG4107RQ2 Cytochrome c oxidase, subunit I BME96_09965 ENOG4105NAA Cytochrome C oxidase, subunit II BME96_09985 ENOG4105VEQ Cold shock protein BME96_10005 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) BME96_10010 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) BME96_10015 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) BME96_10020 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) BME96_10025 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) BME96_10030 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) BME96_10050 ENOG4105E0X reductase BME96_10070 ENOG41084AG Acylphosphatase BME96_10095 ENOG4108IUE nitrate reductase beta subunit BME96_10120 ENOG4105C6T cysteine synthase BME96_10135 ENOG410890F Dynamin family BME96_10140 ENOG4105MXW flavin reductase domain protein, FMN-binding BME96_10145 ENOG4107QX3 carboxylase BME96_10150 ENOG4105E39 Enoyl-CoA hydratase BME96_10155 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit BME96_10160 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase BME96_10165 ENOG4105CEY Amp-dependent synthetase and ligase BME96_10170 ENOG4105C1G acyl-Coa dehydrogenase BME96_10175 ENOG4105U5Y Transcriptional regulator BME96_10185 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BME96_10190 ENOG4105K4P CoA-binding domain protein BME96_10195 ENOG4105E90 ABC transporter BME96_10205 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) BME96_10210 ENOG4105DZA Converts GTP to 7,8-dihydroneopterin triphosphate (By similarity) BME96_10215 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) BME96_10230 ENOG41067CD Small, acid-soluble spore protein Tlp BME96_10235 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BME96_10240 ENOG4108I0Z Aconitate hydratase BME96_10245 ENOG4105BZU Histidine kinase BME96_10260 ENOG4107YTP response regulator receiver protein BME96_10265 ENOG4105HC0 Na H antiporter BME96_10270 ENOG4107QIV Cytochrome c biogenesis protein BME96_10275 ENOG4105VXM UPF0154 protein BME96_10290 ENOG4105VPS UPF0291 protein BME96_10295 ENOG4108SVB resolvase BME96_10300 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) BME96_10305 ENOG4105C5F glutamine synthetase BME96_10310 ENOG4105KV4 Transcriptional regulator BME96_10315 ENOG4105CXI aluminum resistance protein BME96_10320 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) BME96_10325 ENOG4106F1P AAA ATPase, central domain protein BME96_10330 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) BME96_10335 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) BME96_10340 ENOG4108WPJ Ferritin-like domain BME96_10345 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) BME96_10350 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) BME96_10360 ENOG4108RS6 transposase BME96_10375 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) BME96_10380 ENOG4105MCT stage V sporulation protein S BME96_10385 ENOG4105D48 metallophosphoesterase BME96_10390 ENOG4105E4Y Endoribonuclease that initiates mRNA decay (By similarity) BME96_10395 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) BME96_10400 ENOG4105CEV competence damage-inducible protein BME96_10405 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase BME96_10420 ENOG4105XZV Protein of unknown function (DUF3243) BME96_10425 ENOG4108RKS Short-chain dehydrogenase reductase Sdr BME96_10445 ENOG4105UIB (ABC) transporter BME96_10450 ENOG4108JQ9 ABC transporter BME96_10455 ENOG4105DIH basic membrane BME96_10460 ENOG4105FDP GntR family transcriptional regulator BME96_10465 ENOG4105CNU cell division protein FtsK BME96_10475 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit BME96_10480 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) BME96_10490 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) BME96_10495 ENOG4108S0H Dipicolinic acid synthetase, b subunit BME96_10500 ENOG4105E35 Dipicolinate synthase subunit A BME96_10510 ENOG4105C1V Peptidase, M16 BME96_10520 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) BME96_10525 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) BME96_10530 ENOG4105DTN riboflavin biosynthesis protein ribF BME96_10535 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) BME96_10540 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) BME96_10550 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) BME96_10555 ENOG4105VHM ribosomal protein BME96_10560 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination BME96_10565 ENOG4105CHV Transcription elongation factor NusA BME96_10570 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) BME96_10575 ENOG4107MMM Anti-sigma-factor antagonist BME96_10580 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) BME96_10585 ENOG4105DZP Membrane-associated zinc metalloprotease BME96_10590 ENOG4105KNE Phosphatidate cytidylyltransferase BME96_10595 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) BME96_10600 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) BME96_10605 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) BME96_10610 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) BME96_10615 ENOG4105CE9 30S ribosomal protein S2 BME96_10630 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BME96_10635 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) BME96_10645 ENOG4108V3W Chemotaxis protein, CheW BME96_10650 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) BME96_10660 ENOG4105FZW flagellar biosynthesis regulator FlhF BME96_10665 ENOG4105D7B Flagellar biosynthesis protein flha BME96_10670 ENOG4105D00 flagellar biosynthetic protein flhB BME96_10675 ENOG4105D19 Role in flagellar biosynthesis (By similarity) BME96_10680 ENOG4105VS8 Flagellar biosynthetic protein fliq BME96_10685 ENOG4105CN7 Flagellar biosynthetic protein FliP BME96_10695 ENOG4107YTP response regulator receiver protein BME96_10700 ENOG4105DD5 Flagellar motor switch protein BME96_10705 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) BME96_10715 ENOG41068WV flagellar FlbD family protein BME96_10720 ENOG4108JQA flagellar BME96_10730 ENOG410822I Flagellar hook capping protein BME96_10760 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) BME96_10765 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) BME96_10770 ENOG4105VQ0 flagellar hook-basal body complex protein fliE BME96_10775 ENOG4108ZC9 flagellar basal-body rod protein flgc BME96_10780 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) BME96_10785 ENOG4105EUM DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor (By similarity) BME96_10790 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) BME96_10795 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) BME96_10800 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BME96_10815 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) BME96_10820 ENOG4105C79 DNA protecting protein DprA BME96_10825 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha BME96_10830 ENOG4105CMV Succinyl-CoA synthetase subunit beta BME96_10835 ENOG4105D00 flagellar biosynthetic protein flhB BME96_10845 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) BME96_10850 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) BME96_10860 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) BME96_10865 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) BME96_10870 ENOG4107Z8R An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) BME96_10880 ENOG4105VB6 UPF0109 protein BME96_10885 ENOG4105K5M 30s ribosomal protein S16 BME96_10895 ENOG4105VBN Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) BME96_10900 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) BME96_10905 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) BME96_10910 ENOG4108CPA Protein of unknown function (DUF1128) BME96_10915 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) BME96_10920 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) BME96_10925 ENOG4105CHR reductase BME96_10930 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase BME96_10935 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) BME96_10940 ENOG4108VVV Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism (By similarity) BME96_10945 ENOG4105CB5 ATP-dependent DNA helicase recG BME96_10950 ENOG4105EJQ L-serine dehydratase BME96_10965 ENOG4105DP4 dak2 domain fusion protein ylov BME96_10970 ENOG4108ZAA Alkaline-shock protein BME96_10975 ENOG4105VB9 50S ribosomal protein l28 BME96_10985 ENOG4105FJ0 thiamine BME96_10990 ENOG4105DJV ribulose-phosphate 3-epimerase BME96_10995 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) BME96_11000 ENOG4105D9P serine threonine protein kinase BME96_11005 ENOG4108ZF3 Phosphatase BME96_11010 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B BME96_11015 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) BME96_11020 ENOG4105C25 Primosomal protein n' BME96_11025 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase BME96_11030 ENOG4105ZAD Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) BME96_11035 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) BME96_11040 ENOG4105KC4 UPF0296 protein BME96_11050 ENOG4105F23 Fibronectin-binding protein BME96_11055 ENOG4108ZHJ Organic hydroperoxide resistance protein BME96_11060 ENOG4108KAM Transcriptional regulator BME96_11065 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) BME96_11070 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) BME96_11075 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) BME96_11080 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) BME96_11085 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain BME96_11090 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain BME96_11095 ENOG4105CD3 dihydroorotase BME96_11100 ENOG4105CXT aspartate transcarbamylase BME96_11105 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) BME96_11110 ENOG4105C34 Pseudouridine synthase BME96_11115 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) BME96_11125 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) BME96_11135 ENOG4105DBK s4 domain protein BME96_11140 ENOG41067XK integral membrane protein BME96_11145 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) BME96_11150 ENOG4105DFA alanine racemase domain protein BME96_11155 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase BME96_11160 ENOG4105WR5 sporulation protein, YlmC YmxH family BME96_11170 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BME96_11175 ENOG4108AWX Sporulation factor SpoIIGA BME96_11180 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) BME96_11185 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) BME96_11190 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) BME96_11195 ENOG4105CNI cell division protein FtsW BME96_11200 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) BME96_11205 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) BME96_11210 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) BME96_11215 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) BME96_11220 ENOG4105CJN penicillin-binding protein BME96_11225 ENOG4105CJN penicillin-binding protein BME96_11230 ENOG41068DC Essential cell division protein (By similarity) BME96_11235 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) BME96_11240 ENOG4108V6E Cell division protein mraZ BME96_11245 ENOG41074B2 UPF0747 protein BME96_11260 ENOG4108YG3 N-acetyltransferase BME96_11270 ENOG4105E39 Enoyl-CoA hydratase BME96_11275 ENOG41067VY 50S ribosomal protein L32 BME96_11280 ENOG4105KNH Nucleic acid-binding protein BME96_11285 ENOG4105CDE UPF0348 protein BME96_11290 ENOG41063PX domain protein BME96_11295 ENOG4105H20 Sporulation integral membrane protein YlbJ BME96_11300 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) BME96_11305 ENOG4106H78 methyltransferase BME96_11310 ENOG4105WUC UPF0298 protein BME96_11330 ENOG4106UY4 Inherit from COG: Scp-like extracellular BME96_11345 ENOG4108SJC Membrane BME96_11360 ENOG4105CCU oxidase (Subunit III) BME96_11365 ENOG4105BZ9 Cytochrome C oxidase, subunit I BME96_11375 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) BME96_11380 ENOG4107SGF Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity) BME96_11385 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) BME96_11390 ENOG4105CNI cell division protein FtsW BME96_11395 ENOG4105ZPI UPF0358 protein BME96_11420 ENOG4105QA2 BME96_11425 ENOG4105ECY inositol monophosphatase BME96_11435 ENOG4108WQ8 UPF0637 protein BME96_11440 ENOG4105WBI UPF0223 protein BME96_11445 ENOG4105EA8 2-Nitropropane dioxygenase BME96_11450 ENOG4105CXN decarboxylase BME96_11475 ENOG4105CPP Dehydrogenase, E1 component BME96_11490 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) BME96_11495 ENOG4108X4Q Hydrolase BME96_11500 ENOG4106148 UPF0356 protein BME96_11505 ENOG4105CN5 Metallo-Beta-Lactamase BME96_11515 ENOG4107ZYR domain protein BME96_11520 ENOG4105BZ1 (ABC) transporter BME96_11525 ENOG4105BZ1 (ABC) transporter BME96_11530 ENOG4107R19 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BME96_11535 ENOG4105D3R alkyl hydroperoxide reductase BME96_11545 ENOG4105CH2 amidohydrolase BME96_11550 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) BME96_11560 ENOG4105KTU Transcriptional regulator, arsr family BME96_11565 ENOG4105PGM cation diffusion facilitator family transporter BME96_11570 ENOG4105K6S Short-chain dehydrogenase reductase Sdr BME96_11580 ENOG4105UIN BME96_11595 ENOG4108TVT permease BME96_11600 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) BME96_11605 ENOG4105CHM Aminotransferase BME96_11615 ENOG4105C3F Signal peptidase i BME96_11625 ENOG4105C0H protease BME96_11630 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR BME96_11645 ENOG4105CK7 Sodium proline symporter BME96_11660 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) BME96_11665 ENOG4105CVM Molybdenum cofactor synthesis domain protein BME96_11685 ENOG41090VF Stage v sporulation protein ac BME96_11690 ENOG4105CZ3 stage V sporulation protein ad BME96_11705 ENOG4108QY0 Membrane BME96_11715 ENOG4105CB2 alcohol dehydrogenase BME96_11720 ENOG4105D0U Arsenite-activated ATPase (ArsA) BME96_11730 ENOG4105D22 carbon starvation protein BME96_11740 ENOG4108HIZ formate dehydrogenase alpha subunit BME96_11745 ENOG4105D82 Glutamate dehydrogenase BME96_11760 ENOG4105N67 Proton-coupled thiamine transporter YuaJ BME96_11765 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) BME96_11770 ENOG4105S6R Iron-hydroxamate transporter permease subunit BME96_11775 ENOG4105J76 Periplasmic binding protein BME96_11785 ENOG41073R8 VanW family BME96_11795 ENOG4105CEP NADH dehydrogenase BME96_11810 ENOG4105CEY Amp-dependent synthetase and ligase BME96_11820 ENOG4105C9U ATP-dependent DNA helicase RecQ BME96_11825 ENOG4105EEQ Na H antiporter BME96_11850 ENOG41079P0 BME96_11890 ENOG4105JQZ Methyltransferase BME96_11900 ENOG4107RVU D-Ala-D-Ala carboxypeptidase 3 (S13) family BME96_11910 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) BME96_11915 ENOG4107ZE5 PPIases accelerate the folding of proteins BME96_11925 ENOG4105EMU Dehydrogenase BME96_11930 ENOG4108Z6K Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant (By similarity) BME96_11935 ENOG4108JPW Aminotransferase BME96_11950 ENOG4105R40 Glycine betaine carnitine choline BME96_11955 ENOG4108HQR Glycine betaine BME96_11960 ENOG4105E90 ABC transporter BME96_11970 ENOG4107HG4 Transcriptional regulator BME96_11980 ENOG4105E35 Dipicolinate synthase subunit A BME96_11990 ENOG4105DZC cytosine deaminase BME96_11995 ENOG4105DQW permease for cytosine purines, uracil, thiamine, allantoin BME96_12005 ENOG4105C26 Dehydrogenase BME96_12010 ENOG4105C1G acyl-Coa dehydrogenase BME96_12015 ENOG4105CC9 acyl-Coa dehydrogenase BME96_12035 ENOG410900P UPF0336 protein BME96_12040 ENOG4105CD5 CoA-binding domain protein BME96_12070 ENOG41085GJ domain protein BME96_12080 ENOG4105C8T Leucyl-tRNA synthetase BME96_12090 ENOG4108Z0R Transferase BME96_12095 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP BME96_12100 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase BME96_12105 ENOG4105D2X ABC transporter substrate-binding protein BME96_12115 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component BME96_12135 ENOG4105E0A ABC, transporter BME96_12140 ENOG4105CEY Amp-dependent synthetase and ligase BME96_12145 ENOG4108IPT Naphthoate synthase BME96_12150 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) BME96_12155 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) BME96_12160 ENOG4105E4F Isochorismate synthase BME96_12165 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase BME96_12170 ENOG4105KA0 thioesterase Superfamily protein BME96_12180 ENOG4108SAX Membrane BME96_12190 ENOG4105CN9 Peptidase m42 family protein BME96_12200 ENOG4107PBV potassium channel BME96_12215 ENOG4105WG9 Conserved Protein BME96_12220 ENOG4107QYV phosphohexose isomerase BME96_12225 ENOG4105C87 Aminotransferase class I and II BME96_12245 ENOG4105KRI phosphocarrier protein (HPr BME96_12250 ENOG4105D3A purine nucleoside phosphorylase DeoD-type BME96_12260 ENOG41069ER domain protein BME96_12270 ENOG4105CEP NADH dehydrogenase BME96_12275 ENOG4105CAY ferredoxin--nadp reductase BME96_12280 ENOG4108YX9 iron--sulfur cluster insertion protein erpA BME96_12285 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) BME96_12295 ENOG41083MR nifu domain-containing protein BME96_12300 ENOG4105C5I Dehydrogenase BME96_12310 ENOG4108W5N phosphatidylglycerophosphatase a BME96_12315 ENOG4105D4U had-superfamily hydrolase, subfamily iia BME96_12335 ENOG4105EUF amidase EC 3.5.1.4 BME96_12345 ENOG4105MMD transcriptional regulator BME96_12350 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) BME96_12355 ENOG4105FAA peptidase M23 BME96_12360 ENOG4105C8J )-transporter BME96_12365 ENOG4107S6Z Na H antiporter BME96_12370 ENOG4108YTE sporulation protein YunB BME96_12375 ENOG4105CPI Metal Dependent Phosphohydrolase BME96_12380 ENOG4105KZD Domain of unknown function (DUF1805) BME96_12385 ENOG4107R8B 5'-nucleotidase BME96_12400 ENOG4105CNU cell division protein FtsK BME96_12455 ENOG4107F2M hemolysin-type calcium-binding region BME96_12585 ENOG4105CDU Replicative dna helicase BME96_12600 ENOG4105Q2H domain protein BME96_12620 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) BME96_12670 ENOG4105DIW FeS assembly protein SUFB BME96_12675 ENOG4108UNV SUF system FeS assembly protein, NifU family BME96_12680 ENOG4105C9B Cysteine desulfurase BME96_12685 ENOG4105JRK feS assembly protein SufD BME96_12690 ENOG4105C3K feS assembly ATPase SufC BME96_12695 ENOG4105D01 (LipO)protein BME96_12700 ENOG4108UMI ABC transporter, permease BME96_12705 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) BME96_12720 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) BME96_12725 ENOG41080E8 Transcriptional regulator, Spx MgsR family BME96_12730 ENOG4105C1G acyl-Coa dehydrogenase BME96_12735 ENOG4105CHU acetyl-coa acetyltransferase BME96_12755 ENOG4105C59 p-type ATPase BME96_12760 ENOG4105VPX protein, conserved in bacteria BME96_12765 ENOG4105DSE periplasmic solute binding protein BME96_12770 ENOG4105FDK ABC transporter BME96_12780 ENOG4105N80 Ferric uptake regulator, Fur family BME96_12785 ENOG4105WMR Protein CrcB homolog BME96_12800 ENOG4105Z8B NlpC/P60 family BME96_12810 ENOG4107QP3 malate synthase g BME96_12815 ENOG4108V3A UPF0421 protein BME96_12820 ENOG4105WH1 Two component transcriptional regulator luxr family BME96_12825 ENOG4105ENE Histidine kinase BME96_12845 ENOG4107RGD Major Facilitator superfamily BME96_12850 ENOG4105DEN Luciferase family BME96_12860 ENOG4108UT2 hemolysin iii BME96_12865 ENOG4105DER m42 family BME96_12905 ENOG41090UD (LipO)protein BME96_12915 ENOG4105C59 p-type ATPase BME96_12920 ENOG4105VPX protein, conserved in bacteria BME96_12935 ENOG4105BZU Histidine kinase BME96_12950 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BME96_12955 ENOG4107QIV Cytochrome c biogenesis protein BME96_12965 ENOG4105VWP Inherit from COG: 4Fe-4S ferredoxin, iron-sulfur binding BME96_12980 ENOG4105BZU Histidine kinase BME96_12985 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BME96_12995 ENOG4108UXE Protein tyrosine phosphatase BME96_13065 ENOG4108UXE Protein tyrosine phosphatase BME96_13070 ENOG4107R5R arsenical pump membrane protein BME96_13075 ENOG41082YX Transcriptional regulator, arsr family BME96_13080 ENOG41085FC arsR family transcriptional regulator BME96_13100 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) BME96_13105 ENOG4105DSE periplasmic solute binding protein BME96_13110 ENOG4105CC5 ABC transporter BME96_13115 ENOG4105DIK (ABC) transporter BME96_13120 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) BME96_13130 ENOG4105XZU Preprotein translocase, subunit SecG BME96_13140 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) BME96_13155 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) BME96_13160 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) BME96_13165 ENOG4105CP7 Triose-phosphate isomerase BME96_13170 ENOG4105BZA Phosphoglycerate kinase BME96_13190 ENOG4105VND Ribonuclease BME96_13205 ENOG4105CY2 Citrate transporter BME96_13210 ENOG4105CHU acetyl-coa acetyltransferase BME96_13215 ENOG4105DTD Dehydrogenase BME96_13220 ENOG4108IIH CoA-transferase subunit B BME96_13225 ENOG4105D6N CoA-transferase, subunit a BME96_13240 ENOG4105FF2 Type I DHQase BME96_13245 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) BME96_13260 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) BME96_13265 ENOG4105KRI phosphocarrier protein (HPr BME96_13270 ENOG4105CIE May be required for sporulation (By similarity) BME96_13275 ENOG4105CHW UPF0052 protein BME96_13280 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) BME96_13285 ENOG4108Z4K mutator MutT protein BME96_13290 ENOG4105C3M thioredoxin reductase BME96_13300 ENOG4105C6V Glycerol-3-phosphate dehydrogenase BME96_13305 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) BME96_13310 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator BME96_13315 ENOG4108S4C acetyltransferase BME96_13320 ENOG4107XGZ Hydrolase BME96_13325 ENOG4105HKU nucleoside recognition domain-containing protein BME96_13330 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) BME96_13335 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) BME96_13340 ENOG41086DT Membrane protein of unknown function BME96_13345 ENOG41067S9 phage shock protein C, PspC BME96_13350 ENOG4108TN2 lmbE family BME96_13360 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) BME96_13365 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) BME96_13380 ENOG4105CN1 protease BME96_13385 ENOG4105DR5 peptidase BME96_13390 ENOG4105CRP Part of the ABC transporter FtsEX involved in BME96_13395 ENOG4105CAK Cell division ATP-binding protein ftsE BME96_13405 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) BME96_13410 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving BME96_13415 ENOG4105MS2 ribosomal subunit Interface protein BME96_13420 ENOG41069ZS flagellar protein BME96_13425 ENOG4105MQ3 flagellar protein FliS BME96_13430 ENOG41083S7 flagellar protein FlaG BME96_13435 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) BME96_13440 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) BME96_13450 ENOG4105DTJ flagellar hook-associated protein BME96_13455 ENOG4105E1Q flagellar hook-associated protein BME96_13470 ENOG4105RU3 BME96_13475 ENOG41081UC Inherit from COG: Competence protein BME96_13490 ENOG4105WH1 Two component transcriptional regulator luxr family BME96_13495 ENOG4105BZU Histidine kinase BME96_13500 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein BME96_13505 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) BME96_13510 ENOG4105CE4 GlcNAc 6-P deacetylase BME96_13515 ENOG4105CI1 PTS System BME96_13525 ENOG4108IMY Transcriptional regulator BME96_13535 ENOG4105VFR signal peptidase BME96_13560 ENOG4108KGH TRANSCRIPTIONal BME96_13565 ENOG4107RVG penicillin-binding protein BME96_13585 ENOG4105C26 Dehydrogenase BME96_13600 ENOG410605W Major Facilitator BME96_13610 ENOG4105E7W lamb ycsf family protein BME96_13615 ENOG4105P4J Allophanate hydrolase, subunit 1 BME96_13620 ENOG4105C8P )-transporter BME96_13625 ENOG4105D94 Major Facilitator Superfamily BME96_13630 ENOG4105DJ2 Major Facilitator Superfamily BME96_13640 ENOG4105E0M Sulfatase BME96_13655 ENOG4105C8Q Methyl-accepting chemotaxis BME96_13660 ENOG4105BZU Histidine kinase BME96_13665 ENOG4107YTP response regulator receiver protein BME96_13670 ENOG4108V3W Chemotaxis protein, CheW BME96_13675 ENOG4105CBS Chea signal transduction histidine kinase BME96_13685 ENOG4105ER2 Ompa motb domain protein BME96_13690 ENOG4105E14 MotA TolQ exbB proton channel BME96_13695 ENOG4105FKZ Methyl-accepting chemotaxis BME96_13700 ENOG4105C26 Dehydrogenase BME96_13705 ENOG4107RT6 flagellar hook-associated BME96_13740 ENOG4106YBV Methyl-accepting chemotaxis BME96_13750 ENOG4105CK7 Sodium proline symporter BME96_13760 ENOG4105D17 glycoside hydrolase, family 3 domain protein BME96_13765 ENOG4105EHZ conserved protein UCP016719 BME96_13770 ENOG4105DRS transport system, permease BME96_13775 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component BME96_13785 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate BME96_13810 ENOG4105C7Z Conserved Protein BME96_13855 ENOG4105QNR S1 RNA binding domain protein BME96_13880 ENOG4108X4Q Hydrolase BME96_13900 ENOG4108MRH transcriptional regulatory protein BME96_13905 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism BME96_13910 ENOG4105CXY transporter BME96_13915 ENOG4105C7B Threonine dehydratase BME96_13930 ENOG4105E66 phosphoriboisomerase A BME96_13950 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BME96_13955 ENOG4108JQ7 (ABC) transporter BME96_13965 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) BME96_13970 ENOG4105C1B dTDP-glucose 4-6-dehydratase BME96_13975 ENOG4105CKK Glycosyl transferase, family 2 BME96_13985 ENOG41060GT Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) BME96_13990 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase BME96_14000 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) BME96_14020 ENOG4105C7B Threonine dehydratase BME96_14025 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) BME96_14030 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) BME96_14035 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) BME96_14040 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) BME96_14045 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase BME96_14050 ENOG4108ZP8 Acetolactate synthase small subunit BME96_14055 ENOG4105C7K acetolactate synthase BME96_14060 ENOG4105C01 Dihydroxy-acid dehydratase BME96_14065 ENOG4105C09 Bile acid BME96_14070 ENOG4105EFZ amidohydrolase BME96_14075 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) BME96_14080 ENOG4107S6Z Na H antiporter BME96_14085 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) BME96_14110 ENOG4105C26 Dehydrogenase BME96_14115 ENOG4108JPW Aminotransferase BME96_14120 ENOG4105DRR Transcriptional regulator, GntR family BME96_14125 ENOG4105C5I Dehydrogenase BME96_14160 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) BME96_14165 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) BME96_14180 ENOG41061TZ Short-chain dehydrogenase reductase Sdr BME96_14190 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase BME96_14205 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BME96_14210 ENOG4105DCF alanine dehydrogenase BME96_14215 ENOG4105FDP GntR family transcriptional regulator BME96_14220 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) BME96_14230 ENOG4105E5Q amino acid AbC transporter BME96_14235 ENOG4107R0W ABC transporter BME96_14240 ENOG4105C26 Dehydrogenase BME96_14245 ENOG4105ETU transcriptional activator (TenA BME96_14250 ENOG4105C94 Transporter BME96_14260 ENOG4105NQN cytochrome C BME96_14265 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) BME96_14270 ENOG4105BZ9 Cytochrome C oxidase, subunit I BME96_14290 ENOG4105EYH Exonuclease BME96_14295 ENOG4107RFY SbcCD D subunit BME96_14315 ENOG4107MII Sugar-specific transcriptional regulator TrmB BME96_14320 ENOG4105CZM Major Facilitator BME96_14325 ENOG4105DWF phosphomethylpyrimidine kinase BME96_14330 ENOG4108JJB ABC transporter BME96_14335 ENOG4105C4B ABC transporter, permease BME96_14350 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) BME96_14370 ENOG41088SP formiminoglutamate hydrolase BME96_14375 ENOG4105D6U Sodium Glutamate Symporter BME96_14385 ENOG4105DE4 1-phosphofructokinase BME96_14390 ENOG4105D2M Aldolase BME96_14395 ENOG4105CE4 GlcNAc 6-P deacetylase BME96_14405 ENOG4105F3R pts system mannose fructose sorbose family iid BME96_14410 ENOG4105ETZ PTS System BME96_14415 ENOG4108RG5 PTS system N-acetylgalactosamine-specific transporter subunit IIB BME96_14420 ENOG4105E70 isomerase BME96_14425 ENOG4108X79 transcriptional regulator BME96_14435 ENOG4105BZW Glycerate kinase BME96_14445 ENOG4105CBG Sulfatase BME96_14450 ENOG4105CT8 Phosphorylase BME96_14460 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component BME96_14465 ENOG4105EPJ extracellular solute-binding protein family 1 BME96_14470 ENOG4105W4W Transcriptional regulator BME96_14495 ENOG4108KGH TRANSCRIPTIONal BME96_14535 ENOG4105FE1 phytoene synthase BME96_14550 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) BME96_14555 ENOG4105C8Q Methyl-accepting chemotaxis BME96_14560 ENOG4105DTE Xanthine uracil vitamin C permease BME96_14570 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BME96_14580 ENOG4105DC7 peptidase M24 BME96_14600 ENOG4105EU0 Major facilitator Superfamily BME96_14610 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) BME96_14615 ENOG4105D7V transposase BME96_14630 ENOG4105VKD bioY protein BME96_14645 ENOG4105DFD Na H antiporter BME96_14650 ENOG4105DYB Isoaspartyl dipeptidase BME96_14655 ENOG4108JUB Transcriptional regulator BME96_14660 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) BME96_14665 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) BME96_14675 ENOG4107VRI Transcriptional regulator BME96_14680 ENOG4105JHY Membrane BME96_14690 ENOG4108UZX fmn reductase BME96_14695 ENOG4105CK7 Sodium proline symporter BME96_14705 ENOG4105C26 Dehydrogenase BME96_14715 ENOG4105CI2 imidazolone-5-propionate hydrolase BME96_14725 ENOG4108R6W Transcriptional regulator, ARAC family BME96_14740 ENOG410756H nucleotidyltransferase BME96_14755 ENOG4105J8Z peptidase S8 and S53, subtilisin, kexin, sedolisin BME96_14760 ENOG4105F22 Major Facilitator Superfamily BME96_14765 ENOG4108IGT Dipeptidase BME96_14770 ENOG4105DTQ mandelate racemase muconate lactonizing BME96_14775 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin BME96_14780 ENOG4107RVU D-Ala-D-Ala carboxypeptidase 3 (S13) family BME96_14785 ENOG4108JYZ YitT family BME96_14790 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein BME96_14795 ENOG4105DEN Luciferase family BME96_14800 ENOG4105CPE K01197 hyaluronoglucosaminidase EC 3.2.1.35 BME96_14805 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) BME96_14810 ENOG4107QR9 Iron-sulfur cluster binding protein BME96_14815 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) BME96_14820 ENOG4105JXH GntR family transcriptional regulator BME96_14835 ENOG4106KNT transcriptional regulator BME96_14840 ENOG4105C9S Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (By similarity) BME96_14850 ENOG4105C5Y PTS System BME96_14860 ENOG4107SCR N-acetylneuraminate lyase BME96_14865 ENOG4105C9S Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (By similarity) BME96_14875 ENOG4105CG6 trap dicarboxylate transporter dctm subunit BME96_14885 ENOG4108ERU trap dicarboxylate transporter subunit DctP BME96_14965 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) BME96_14975 ENOG4105CHR reductase BME96_14980 ENOG4107R8N Glycosyl transferase, family 2 BME96_15000 ENOG4105WH1 Two component transcriptional regulator luxr family BME96_15025 ENOG4105BZ1 (ABC) transporter BME96_15035 ENOG4105C26 Dehydrogenase BME96_15040 ENOG4105C8Q Methyl-accepting chemotaxis BME96_15050 ENOG4105ETE Transcriptional regulator (LacI family BME96_15070 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) BME96_15080 ENOG4105DT3 PTS system, galactitol-specific IIc component BME96_15090 ENOG4105D06 uba thif-type nad fad binding protein BME96_15095 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) BME96_15100 ENOG41080HI glycine oxidase BME96_15105 ENOG4108VEU Thiamine monophosphate synthase BME96_15115 ENOG4105C5B carbamate kinase BME96_15140 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate BME96_15145 ENOG4105EHZ conserved protein UCP016719 BME96_15150 ENOG4105D17 glycoside hydrolase, family 3 domain protein BME96_15155 ENOG4105DRS transport system, permease BME96_15160 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component BME96_15180 ENOG4105CPK Glycosyl transferase (Group 1 BME96_15190 ENOG4105G0J serine threonine protein kinase BME96_15195 ENOG4107QQG Dehydrogenase BME96_15220 ENOG4105C1B dTDP-glucose 4-6-dehydratase BME96_15240 ENOG4105CFC Transporter BME96_15245 ENOG4107QP6 Xylose isomerase domain protein TIM barrel BME96_15250 ENOG4105CK5 oxidoreductase BME96_15265 ENOG4105CK5 oxidoreductase BME96_15280 ENOG4107T3P ABC, transporter BME96_15285 ENOG4108PSK reductase BME96_15290 ENOG4105ETE Transcriptional regulator (LacI family BME96_15310 ENOG4105DTQ mandelate racemase muconate lactonizing BME96_15335 ENOG4105C0A alcohol dehydrogenase BME96_15340 ENOG4105CG6 trap dicarboxylate transporter dctm subunit BME96_15345 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit BME96_15350 ENOG4105FDP GntR family transcriptional regulator BME96_15375 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase BME96_15380 ENOG4105KVH Transcriptional regulator BME96_15385 ENOG4105CBG Sulfatase BME96_15400 ENOG4107UWC ABC, transporter BME96_15415 ENOG4105E6M Sulphatase-modifying factor protein BME96_15420 ENOG4105DUM transcriptional regulator, lysR family BME96_15435 ENOG4107YH7 Beta-lactamase (EC 3.5.2.6) BME96_15445 ENOG4105D3Y Na H antiporter BME96_15450 ENOG4105C84 Histidine ammonia-lyase BME96_15455 ENOG4105DWD nucleoside recognition domain protein BME96_15460 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) BME96_15465 ENOG4105CI2 imidazolone-5-propionate hydrolase BME96_15470 ENOG4105CGP Urocanate hydratase BME96_15475 ENOG4105DUM transcriptional regulator, lysR family BME96_15485 ENOG41067TZ transcriptional regulator, MarR family BME96_15490 ENOG4105EYF MMPL domain protein BME96_15540 ENOG4105E0A ABC, transporter BME96_15545 ENOG4108IHU transport system permease protein BME96_15550 ENOG4105DQ5 transport system permease protein BME96_15555 ENOG4108MES Periplasmic binding protein BME96_15565 ENOG4105VFR signal peptidase BME96_15600 ENOG4105ESP cell wall surface anchor family protein BME96_15605 ENOG4105EX0 alpha-galactosidase BME96_15615 ENOG4105J7I hydrolase BME96_15620 ENOG4105D2N Aldolase BME96_15625 ENOG4105DM4 PTS System BME96_15630 ENOG4105DM4 PTS System BME96_15635 ENOG4105DE4 1-phosphofructokinase BME96_15640 ENOG4105HX0 Transcriptional regulator BME96_15645 ENOG4105C26 Dehydrogenase BME96_15650 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) BME96_15655 ENOG4105DFD Na H antiporter BME96_15665 ENOG4105CTU Proline racemase BME96_15670 ENOG4105MWK D-amino acid dehydrogenase, small subunit BME96_15695 ENOG4108ME1 Peptidase M55 D-aminopeptidase BME96_15745 ENOG4105PAD Hydrolase BME96_15755 ENOG4105C5F glutamine synthetase BME96_15760 ENOG4105BZ8 glutamate synthase BME96_15765 ENOG4105CBC glutamate synthase BME96_15770 ENOG4105C5Q Transcriptional regulator BME96_15775 ENOG4105CAQ asparagine synthetase BME96_15780 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase BME96_15795 ENOG4107EV6 Inherit from COG: YD repeat protein BME96_15820 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) BME96_15825 ENOG4107R8N Glycosyl transferase, family 2 BME96_15865 ENOG4105DFD Na H antiporter BME96_15870 ENOG4107EPV Aminotransferase class V BME96_15880 ENOG4107WCQ Anion-transporting ATPase BME96_15890 ENOG4105TCD Broad-specificity glycosaminoglycan lyase (By similarity) BME96_15900 ENOG4108K88 Membrane BME96_15905 ENOG4105DTQ mandelate racemase muconate lactonizing BME96_15920 ENOG4108PSC Represses the expression of the murPQ operon involved in the uptake and degradation of N-acetylmuramic acid (MurNAc). Binds to two adjacent inverted repeats within the operator region. MurNAc 6-phosphate, the substrate of MurQ, is the specific inducer that weakens binding of MurR to the operator (By similarity) BME96_15925 ENOG4106A7E Transcriptional regulator BME96_15930 ENOG4105CSU acyl-Coa dehydrogenase BME96_15935 ENOG4105CEY Amp-dependent synthetase and ligase BME96_15940 ENOG4105W1Y Transcriptional regulator BME96_16005 ENOG4105I03 Flagellin BME96_16035 ENOG4108K88 Membrane BME96_16040 ENOG4107W25 arginase agmatinase formiminoglutamase BME96_16085 ENOG4108I69 Glycosyl transferases group 1 BME96_16090 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) BME96_16100 ENOG4108PQP glycosyl transferase group 1 BME96_16115 ENOG4105D3Q Sugar transferase BME96_16120 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase BME96_16125 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase BME96_16135 ENOG4105WH1 Two component transcriptional regulator luxr family BME96_16145 ENOG4108RB3 Capsular polysaccharide biosynthesis protein BME96_16150 ENOG4107YJ4 chain length determinant protein BME96_16155 ENOG4105HTX biosynthesis protein BME96_16205 ENOG4106IQC argininosuccinate lyase BME96_16215 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BME96_16220 ENOG4105C4Y ABC transporter BME96_16240 ENOG4105E2R ROK family BME96_16250 ENOG4107RUZ Sss sodium solute transporter superfamily BME96_16255 ENOG4105DG6 mannose-6-phosphate isomerase BME96_16260 ENOG4105DKQ ROK family BME96_16270 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component BME96_16280 ENOG4105EQD regulatoR BME96_16285 ENOG4105C2F Histidine kinase BME96_16290 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator BME96_16295 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) BME96_16305 ENOG4105CMR udp-glucose 4-epimerase BME96_16315 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) BME96_16320 ENOG4106N3A copper homeostasis protein cutc BME96_16335 ENOG4105ETD TRANSCRIPTIONal BME96_16345 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme BME96_16390 ENOG4108KGH TRANSCRIPTIONal BME96_16395 ENOG4105ESV Glycosyl transferase, family 4 BME96_16400 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) BME96_16410 ENOG4105K64 Glycosyl transferase, family 2 BME96_16430 ENOG4108QXE glycerophosphoryl diester phosphodiesterase BME96_16440 ENOG4105EY8 ABC transporter BME96_16450 ENOG4107RZX Teichoic acid biosynthesis protein BME96_16460 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase BME96_16465 ENOG4108NMT An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon (By similarity) BME96_16470 ENOG4107SJB teichoic acid biosynthesis BME96_16475 ENOG4108FQ0 the rest of the oligosaccharide is released intact. Cleaves the peptidoglycan connecting the daughter cells at the end of the cell division cycle, resulting in the separation of the two newly divided cells. Acts as an autolysin in penicillin-induced lysis BME96_16480 ENOG4107ZIC Glycerol-3-phosphate cytidylyltransferase BME96_16485 ENOG4107RZX Teichoic acid biosynthesis protein BME96_16490 ENOG4107ZIC Glycerol-3-phosphate cytidylyltransferase BME96_16495 ENOG4107RZX Teichoic acid biosynthesis protein BME96_16500 ENOG4105E0M Sulfatase BME96_16520 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) BME96_16525 ENOG4105ESV Glycosyl transferase, family 4 BME96_16545 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component BME96_16560 ENOG4108MR7 Arylsulfotransferase BME96_16570 ENOG41080TC multidrug resistance protein BME96_16575 ENOG410839T multidrug resistance protein BME96_16585 ENOG4105VCP PTS System BME96_16595 ENOG4105F8D glycoside hydrolase family 4 BME96_16600 ENOG4108X79 transcriptional regulator BME96_16605 ENOG410901P UPF0249 protein BME96_16625 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase BME96_16640 ENOG41067SE Tetr family transcriptional regulator BME96_16660 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) BME96_16670 ENOG4105CGA flagellar basal-body rod protein FlgG BME96_16680 ENOG4105DFF Rod shape-determining protein mreb BME96_16690 ENOG4105MT0 Sporulation transcriptional regulator spoiiid BME96_16700 ENOG4105FRN stage II sporulation protein BME96_16710 ENOG4108JQ7 (ABC) transporter BME96_16715 ENOG4107SN7 NLP P60 protein BME96_16720 ENOG4105DTQ mandelate racemase muconate lactonizing BME96_16725 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A BME96_16735 ENOG4105C3U ABC transporter BME96_16740 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BME96_16745 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BME96_16750 ENOG4108ME1 Peptidase M55 D-aminopeptidase BME96_16755 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) BME96_16770 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) BME96_16775 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) BME96_16780 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) BME96_16785 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) BME96_16790 ENOG4107YZM F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) BME96_16795 ENOG4107ZFM Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) BME96_16800 ENOG4105WS6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) BME96_16805 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) BME96_16815 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin BME96_16820 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase BME96_16825 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) BME96_16830 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) BME96_16835 ENOG4108UIC UPF0340 protein BME96_16840 ENOG4108YZG isomerase BME96_16845 ENOG4107SDU Methyl-accepting chemotaxis BME96_16850 ENOG4107WAU Protein tyrosine phosphatase BME96_16855 ENOG410815N Probably functions as a manganese efflux pump (By similarity) BME96_16860 ENOG4105D7V transposase BME96_16870 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) BME96_16880 ENOG4108ZXQ stage ii sporulation protein r BME96_16885 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) BME96_16890 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) BME96_16895 ENOG4107104 thymidine kinase BME96_16900 ENOG41082DI 50s ribosomal protein l31 BME96_16905 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) BME96_16910 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) BME96_16915 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) BME96_16920 ENOG4105D2N Aldolase BME96_16925 ENOG410812K response regulator receiver protein BME96_16930 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) BME96_16935 ENOG4108Z1Y Participates in both the initiation and recycling phases of transcription. In the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling (By similarity) BME96_16945 ENOG4105D5P Methylmalonyl-coA mutase BME96_16955 ENOG4105DJT lAO AO transport system ATPase BME96_16960 ENOG4105C1G acyl-Coa dehydrogenase BME96_16965 ENOG4105C1G acyl-Coa dehydrogenase BME96_16970 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase BME96_16980 ENOG4105DF6 Fe-S oxidoreductase BME96_16985 ENOG4105C75 arginyL-tRNA synthetase BME96_17000 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) BME96_17005 ENOG4105BZ4 penicillin-binding protein BME96_17010 ENOG4108XFG YwhD family BME96_17020 ENOG4105DCI Phosphohydrolase BME96_17025 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) BME96_17030 ENOG4108IJ2 phosphate acetyltransferase BME96_17035 ENOG4107JTW chlorite dismutase BME96_17065 ENOG4105CBC glutamate synthase BME96_17080 ENOG4105DWD nucleoside recognition domain protein BME96_17090 ENOG4108TGC Acyltransferase BME96_17100 ENOG4105FDF Could be involved in DNA repair (By similarity) BME96_17105 ENOG4105DQE DNA ligase BME96_17115 ENOG4108X3M OsmC Ohr family protein BME96_17125 ENOG4105K78 MarR family Transcriptional regulator BME96_17130 ENOG4107TS3 membrane protein, TerC BME96_17165 ENOG4105C9U ATP-dependent DNA helicase RecQ BME96_17180 ENOG4108S4H thioesterase Superfamily protein BME96_17185 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) BME96_17190 ENOG4105C28 cystathionine BME96_17195 ENOG4105FR1 rard protein BME96_17205 ENOG41090WU lipolytic protein G-D-S-L family BME96_17210 ENOG4105QZP Uncharacterized protein conserved in bacteria (DUF2140) BME96_17230 ENOG4105C5H ABC transporter BME96_17235 ENOG4105EXW epimerase dehydratase BME96_17240 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) BME96_17245 ENOG41069ER domain protein BME96_17245 ENOG41069ER domain protein BME96_17250 ENOG4105PTM secreted protein BME96_17265 ENOG4107QW4 alcohol dehydrogenase BME96_17270 ENOG4105KME endoribonuclease L-psp BME96_17305 ENOG4105CEY Amp-dependent synthetase and ligase BME96_17310 ENOG4108JQ7 (ABC) transporter BME96_17320 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BME96_17325 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BME96_17340 ENOG4105EA8 2-Nitropropane dioxygenase BME96_17345 ENOG4105C0D helicase BME96_17350 ENOG4105CZM Major Facilitator BME96_17355 ENOG4106KNT transcriptional regulator BME96_17365 ENOG4105C6Z Gluconate BME96_17370 ENOG4105CMG Carbohydrate kinase BME96_17385 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BME96_17395 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family BME96_17400 ENOG4108IUX (ABC) transporter BME96_17415 ENOG4108WS4 fmn reductase BME96_17420 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase BME96_17430 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) BME96_17450 ENOG41068WN BME96_17465 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BME96_17475 ENOG4107QYD Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BME96_17480 ENOG4105C5Q Transcriptional regulator BME96_17485 ENOG4105D82 Glutamate dehydrogenase BME96_17490 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) BME96_17520 ENOG4105C94 Transporter BME96_17530 ENOG410900G Protein of unknown function (DUF421) BME96_17535 ENOG4105CAQ asparagine synthetase BME96_17545 ENOG4105JVQ RNA Polymerase BME96_17550 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) BME96_17570 ENOG4105CH6 catalase BME96_17575 ENOG4105BZU Histidine kinase BME96_17585 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs BME96_17590 ENOG4105DEN Luciferase family BME96_17595 ENOG4105CS1 NAD(P)H quinone oxidoreductase BME96_17600 ENOG4105D0M Protease HtpX homolog BME96_17610 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase BME96_17615 ENOG4108S01 response regulator BME96_17620 ENOG4108ZGX Histidine kinase BME96_17625 ENOG4105ECK Fatty Acid Desaturase BME96_17640 ENOG4105DVT helicase BME96_17645 ENOG4105CYC Transferase BME96_17650 ENOG4105DY9 regulatoR BME96_17665 ENOG4105DQ6 Transposase BME96_17675 ENOG41067MG lrgb family BME96_17685 ENOG4105CH7 arginosuccinase BME96_17690 ENOG4105CDH Citrulline--aspartate ligase BME96_17695 ENOG4105KPY Small multidrug resistance protein BME96_17700 ENOG4105KPY Small multidrug resistance protein BME96_17725 ENOG4105EXS phosphate abc transporter BME96_17730 ENOG4105C8U phosphate abc transporter BME96_17735 ENOG4105E2Z phosphate ABC transporter (Permease BME96_17740 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) BME96_17760 ENOG4108QY0 Membrane BME96_17775 ENOG4107RCC Major Facilitator Superfamily BME96_17795 ENOG4105K6V RNA polymerase BME96_17815 ENOG4105D7K pfkb domain protein BME96_17835 ENOG4105C5Y PTS System BME96_17840 ENOG410606W general stress protein BME96_17845 ENOG4108RVA ribokinase BME96_17855 ENOG4105CEE C4-dicarboxylate transporter BME96_17860 ENOG4105ETE Transcriptional regulator (LacI family BME96_17865 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) BME96_17870 ENOG4105CR7 Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA (By similarity) BME96_17875 ENOG4107T2D Phosphoribosylaminoimidazolesuccinocarboxamide synthase BME96_17880 ENOG4108UVJ appr-1-p processing domain protein BME96_17905 ENOG4108S4H thioesterase Superfamily protein BME96_17925 ENOG4105CMU LysR family (Transcriptional regulator BME96_17930 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family BME96_17935 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein BME96_17940 ENOG4105E0C molybdate abc transporter BME96_17945 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) BME96_17955 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase BME96_17965 ENOG4105CID antiterminator BME96_18000 ENOG4108KF3 Electron transport protein SCO1 SenC BME96_18005 ENOG4105MVE transcriptional regulator BME96_18015 ENOG4107QIV Cytochrome c biogenesis protein BME96_18020 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BME96_18025 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BME96_18030 ENOG4105EB3 Histidine kinase BME96_18035 ENOG4107G87 m6 family metalloprotease domain protein BME96_18040 ENOG41085GJ domain protein BME96_18045 ENOG41087NI Sulfite exporter TauE/SafE BME96_18050 ENOG4105VFE sira family BME96_18055 ENOG4107TPS domain protein BME96_18060 ENOG4108ZCA Inherit from COG: pyridine nucleotide-disulfide oxidoreductase BME96_18065 ENOG4105VFE sira family BME96_18070 ENOG41085GJ domain protein BME96_18075 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase BME96_18080 ENOG4105XTG Pfam:DUF156 BME96_18090 ENOG4108JU6 CBS domain protein BME96_18095 ENOG41069DP small acid-soluble spore protein BME96_18105 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) BME96_18115 ENOG4107TPS domain protein BME96_18135 ENOG4105ED1 spovr family BME96_18145 ENOG4106AKX UPF0229 protein BME96_18150 ENOG4105CYN Serine protein kinase BME96_18155 ENOG4105S7S phosphonate abc transporter BME96_18165 ENOG4105D5T phosphonate abc transporter BME96_18175 ENOG4105DB7 PHP domain protein BME96_18180 ENOG4105HRV phosphonate c-p lyase system protein phnl BME96_18185 ENOG4105FD8 phosphonate metabolism protein PhnM BME96_18190 ENOG4105ENV phosphonate C-P lyase system protein PhnK BME96_18195 ENOG4105FT8 Phosphonate metabolism BME96_18220 ENOG4105FDP GntR family transcriptional regulator BME96_18230 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) BME96_18245 ENOG4108UB7 BME96_18255 ENOG4105CAY ferredoxin--nadp reductase BME96_18260 ENOG4105E0A ABC, transporter BME96_18270 ENOG4105DQ5 transport system permease protein BME96_18275 ENOG4105EHG Permease protein BME96_18295 ENOG4105CVG Homoserine O-transsuccinylase BME96_18300 ENOG4105CK2 sodium dicarboxylate symporter BME96_18305 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) BME96_18325 ENOG4105DXB Major Facilitator superfamily BME96_18330 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) BME96_18335 ENOG41061AU MarR family Transcriptional regulator BME96_18345 ENOG4105E98 transcriptional regulator DeoR family BME96_18350 ENOG4105DE4 1-phosphofructokinase BME96_18355 ENOG4105DM4 PTS System BME96_18370 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase BME96_18400 ENOG4105CHR reductase BME96_18410 ENOG4105CYC Transferase BME96_18420 ENOG4105CE7 Amidase, hydantoinase carbamoylase family BME96_18435 ENOG4105CHR reductase BME96_18445 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) BME96_18485 ENOG4108M8H domain protein BME96_18495 ENOG4107SNB ankyrin repeat protein YahD BME96_18500 ENOG4105DZC cytosine deaminase BME96_18520 ENOG4105IJJ transcriptional regulator, crp fnr family BME96_18525 ENOG4105CHR reductase BME96_18530 ENOG4105TRT Transcriptional regulator BME96_18540 ENOG4105C26 Dehydrogenase BME96_18555 ENOG4105C7H Helicase, RecD TraA family BME96_18560 ENOG4105EMD TRANSCRIPTIONal BME96_18565 ENOG4105F8D glycoside hydrolase family 4 BME96_18575 ENOG4105CK1 PTS System BME96_18580 ENOG410901P UPF0249 protein BME96_18585 ENOG4105VCP PTS System BME96_18590 ENOG4105EHZ conserved protein UCP016719 BME96_18605 ENOG4108VKI Cell wall hydrolase BME96_18620 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) BME96_18650 ENOG4105DMF Dehydrogenase BME96_18670 ENOG4105BZU Histidine kinase BME96_18695 ENOG4105CYX Short-chain dehydrogenase reductase Sdr BME96_18705 ENOG4105BZ1 (ABC) transporter BME96_18715 ENOG4105C0H protease BME96_18720 ENOG4105Q2H domain protein BME96_18735 ENOG4105BZU Histidine kinase BME96_18740 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BME96_18745 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis BME96_18750 ENOG4105CDU Replicative dna helicase BME96_18755 ENOG4105K9Q Binds to the 23S rRNA (By similarity) BME96_18760 ENOG4105BZR domain protein BME96_18765 ENOG4108XMW Membrane BME96_18775 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) BME96_18780 ENOG4108UUM single-stranded DNA-binding protein BME96_18785 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) BME96_18790 ENOG4105C3G gtp-binding protein BME96_18795 ENOG4105VDK protein, conserved in bacteria BME96_18800 ENOG4105D8X mechanosensitive ion channel BME96_18810 ENOG4108ZDA Sporulation protein YyaC BME96_18820 ENOG4105C9B Cysteine desulfurase BME96_18825 ENOG4105FA0 parb-like partition protein BME96_18830 ENOG4107QJE Chromosome Partitioning Protein BME96_18835 ENOG410636K Effects nucleoid occlusion by binding relatively nonspecifically to DNA and preventing the assembly of the division machinery in the vicinity of the nucleoid, especially under conditions that disturb the cell cycle. It helps to coordinate cell division and chromosome segregation by preventing the formation of the Z ring through the nucleoid, which would cause chromosome breakage (By similarity) BME96_18840 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) BME96_18845 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) BME96_18850 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) BME96_18855 ENOG4105IIU Aminopeptidase BME96_18860 ENOG4108Z7S Single-stranded nucleic acid binding R3H domain-containing protein BME96_18865 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins BME96_18870 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) BME96_18875 ENOG4105VG0 50S ribosomal protein l34 BME96_18940 ENOG4105C9U ATP-dependent DNA helicase RecQ BME96_18960 ENOG4107QJE Chromosome Partitioning Protein BME96_18965 ENOG4107QJE Chromosome Partitioning Protein