locus-tag	class	description
BME96_00010	COG0592	DNA-directed DNA polymerase activity
BME96_00020	COG2501	S4 domain
BME96_00025	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
BME96_00035	COG0187	DNA topoisomerase II activity
BME96_00040	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BME96_00045	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
BME96_00055	COG0516	GMP reductase activity
BME96_00055	COG0517	IMP dehydrogenase activity
BME96_00065	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
BME96_00070	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
BME96_00075	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
BME96_00080	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BME96_00085	COG2011	ABC-type metal ion transport system permease component
BME96_00090	COG1464	Belongs to the NlpA lipoprotein family
BME96_00105	COG2357	RelA SpoT domain protein
BME96_00115	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BME96_00120	COG1428	Deoxynucleoside kinase
BME96_00125	COG1428	Deoxynucleoside kinase
BME96_00135	COG1301	dicarboxylic acid transport
BME96_00145	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BME96_00150	COG3425	synthase
BME96_00155	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
BME96_00155	COG1017	nitric oxide dioxygenase activity
BME96_00160	COG1959	2 iron, 2 sulfur cluster binding
BME96_00165	COG0693	protein deglycase activity
BME96_00170	COG3858	chitin binding
BME96_00170	COG1388	LysM domain
BME96_00175	COG1335	isochorismatase
BME96_00180	COG0590	tRNA wobble adenosine to inosine editing
BME96_00195	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
BME96_00200	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
BME96_00205	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
BME96_00225	COG1982	Orn Lys Arg decarboxylase major
BME96_00230	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
BME96_00235	COG3870	Protein conserved in bacteria
BME96_00240	COG1728	Protein conserved in bacteria
BME96_00245	COG0470	DNA polymerase III
BME96_00250	COG1774	PSP1 C-terminal conserved region
BME96_00255	COG4467	Involved in initiation control of chromosome replication
BME96_00260	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
BME96_00265	COG2827	Endonuclease containing a URI domain
BME96_00270	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
BME96_00280	COG2002	toxin-antitoxin pair type II binding
BME96_00290	COG0084	hydrolase, TatD family'
BME96_00295	COG3584	3D domain protein
BME96_00295	COG3583	domain protein
BME96_00305	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
BME96_00310	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
BME96_00320	COG4466	Protein conserved in bacteria
BME96_00330	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
BME96_00335	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BME96_00340	COG2088	sporulation resulting in formation of a cellular spore
BME96_00345	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
BME96_00350	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BME96_00355	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
BME96_00360	COG0193	aminoacyl-tRNA hydrolase activity
BME96_00370	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
BME96_00375	COG2002	toxin-antitoxin pair type II binding
BME96_00380	COG2244	polysaccharide biosynthetic process
BME96_00385	COG3956	TIGRFAM MazG family protein
BME96_00390	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
BME96_00415	COG1098	S1 RNA binding domain
BME96_00425	COG2208	phosphoserine phosphatase activity
BME96_00430	COG2304	oxidoreductase activity
BME96_00435	COG0515	serine threonine protein kinase
BME96_00440	COG0037	tRNA processing
BME96_00450	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BME96_00455	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
BME96_00460	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
BME96_00470	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BME96_00475	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
BME96_00480	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
BME96_00485	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
BME96_00490	COG1396	sequence-specific DNA binding
BME96_00495	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
BME96_00575	COG1285	pathogenesis
BME96_00585	COG3880	PFAM UvrB UvrC protein
BME96_00590	COG3869	Catalyzes the specific phosphorylation of arginine residues in
BME96_00595	COG0542	response to heat
BME96_00600	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
BME96_00605	COG4956	integral membrane protein (PIN domain superfamily)
BME96_00610	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BME96_00615	COG1045	serine acetyltransferase
BME96_00620	COG0215	cysteine-tRNA ligase activity
BME96_00630	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BME96_00635	COG3688	RNA-binding protein containing a PIN domain
BME96_00645	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BME96_00650	COG0250	Participates in transcription elongation, termination and antitermination
BME96_00660	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
BME96_00665	COG0081	regulation of translation
BME96_00670	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
BME96_00680	COG2813	Specifically methylates the guanine in position
BME96_00685	COG0085	RNA polymerase activity
BME96_00690	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
BME96_00695	COG1358	cellular component organization or biogenesis
BME96_00700	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
BME96_00705	COG0049	tRNA binding
BME96_00710	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BME96_00715	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BME96_00720	COG0051	transcription antitermination factor activity, RNA binding
BME96_00725	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
BME96_00730	COG0088	Forms part of the polypeptide exit tunnel
BME96_00735	COG0089	rRNA binding
BME96_00740	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
BME96_00745	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
BME96_00750	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
BME96_00755	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
BME96_00760	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
BME96_00765	COG0255	Belongs to the universal ribosomal protein uL29 family
BME96_00770	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
BME96_00775	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
BME96_00780	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
BME96_00785	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
BME96_00790	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
BME96_00795	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
BME96_00800	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
BME96_00805	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
BME96_00810	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
BME96_00815	COG1841	ribosomal large subunit assembly
BME96_00820	COG0200	Binds to the 23S rRNA
BME96_00825	COG0201	protein transport
BME96_00830	COG0563	adenylate kinase activity
BME96_00835	COG2163	COG2163 Ribosomal protein L14E L6E L27E
BME96_00840	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
BME96_00845	COG0257	Belongs to the bacterial ribosomal protein bL36 family
BME96_00850	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
BME96_00855	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
BME96_00860	COG0202	RNA polymerase activity
BME96_00865	COG0203	ribosomal protein L17
BME96_00870	COG1122	ATPase activity
BME96_00875	COG1122	ATPase activity
BME96_00885	COG0101	tRNA pseudouridine synthase activity
BME96_00890	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
BME96_00895	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
BME96_00970	COG1346	cytolysis
BME96_00980	COG0583	DNA-binding transcription factor activity
BME96_00985	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BME96_01005	COG0714	Associated with various cellular activities
BME96_01010	COG4548	von Willebrand factor, type A
BME96_01030	COG1295	ribonuclease BN
BME96_01055	COG0860	N-Acetylmuramoyl-L-alanine amidase
BME96_01060	COG0489	protein tyrosine kinase activity
BME96_01070	COG2194	sulfuric ester hydrolase activity
BME96_01075	COG0726	polysaccharide deacetylase
BME96_01130	COG0494	nUDIX hydrolase
BME96_01135	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
BME96_01140	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BME96_01210	COG1595	DNA-templated transcription, initiation
BME96_01215	COG5662	AntiSigma factor
BME96_01220	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
BME96_01225	COG4856	YbbR-like protein
BME96_01230	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BME96_01240	COG0745	RESPONSE REGULATOR receiver
BME96_01245	COG5002	protein histidine kinase activity
BME96_01245	COG3850	Histidine kinase
BME96_01250	COG0577	efflux transmembrane transporter activity
BME96_01275	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BME96_01280	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
BME96_01285	COG1801	Protein of unknown function DUF72
BME96_01290	COG0488	(ABC) transporter
BME96_01310	COG3706	GGDEF domain
BME96_01310	COG4251	negative regulation of phosphorylation
BME96_01310	COG2203	Gaf domain
BME96_01310	COG5001	Diguanylate cyclase
BME96_01320	COG1271	oxidase subunit
BME96_01325	COG1294	oxidase, subunit
BME96_01330	COG4988	ABC transporter
BME96_01335	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
BME96_01345	COG1309	transcriptional regulator
BME96_01350	COG1131	(ABC) transporter
BME96_01370	COG0243	molybdopterin cofactor binding
BME96_01400	COG2223	nitrite transmembrane transporter activity
BME96_01410	COG2197	response regulator
BME96_01420	COG4585	Histidine kinase
BME96_01430	COG1028	Short-chain dehydrogenase reductase Sdr
BME96_01435	COG1114	Component of the transport system for branched-chain amino acids
BME96_01440	COG1802	Transcriptional regulator
BME96_01445	COG0753	catalase activity
BME96_01450	COG0668	transmembrane transport
BME96_01465	COG1413	lyase activity
BME96_01470	COG1607	acyl-coa hydrolase
BME96_01480	COG2124	cytochrome p450
BME96_01485	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
BME96_01490	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
BME96_01495	COG0083	homoserine kinase activity
BME96_01500	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
BME96_01505	COG0460	homoserine dehydrogenase
BME96_01520	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
BME96_01525	COG2814	Major facilitator Superfamily
BME96_01530	COG1378	Sugar-specific transcriptional regulator TrmB
BME96_01540	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BME96_01570	COG2855	membrane
BME96_01580	COG0789	Transcriptional regulator
BME96_01585	COG0352	thiamine-phosphate diphosphorylase activity
BME96_01590	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
BME96_01605	COG1063	alcohol dehydrogenase
BME96_01625	COG4145	pantothenate transmembrane transporter activity
BME96_01635	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BME96_01645	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BME96_01650	COG5506	Protein of unknown function (DUF1694)
BME96_01665	COG5577	PFAM Coat F domain
BME96_01680	COG0708	Exodeoxyribonuclease III
BME96_01685	COG1725	Transcriptional regulator
BME96_01690	COG1131	(ABC) transporter
BME96_01705	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BME96_01725	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
BME96_01730	COG0095	Lipoate-protein ligase
BME96_01740	COG0159	tryptophan synthase activity
BME96_01745	COG0133	tryptophan synthase activity
BME96_01750	COG0135	phosphoribosylanthranilate isomerase activity
BME96_01755	COG0134	indole-3-glycerol-phosphate synthase activity
BME96_01760	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BME96_01765	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BME96_01765	COG0512	Glutamine amidotransferase of anthranilate synthase
BME96_01770	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
BME96_01775	COG1181	Belongs to the D-alanine--D-alanine ligase family
BME96_01780	COG1115	amino acid carrier protein
BME96_01785	COG0778	Nitroreductase
BME96_01805	COG1418	mRNA catabolic process
BME96_01810	COG1876	peptidase activity
BME96_01815	COG2814	Major facilitator Superfamily
BME96_01820	COG4166	transmembrane transport
BME96_01825	COG1970	mechanosensitive ion channel activity
BME96_01845	COG0519	Catalyzes the synthesis of GMP from XMP
BME96_01850	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
BME96_01855	COG1268	BioY protein
BME96_01860	COG0840	transmembrane signaling receptor activity
BME96_01875	COG0656	L-ascorbic acid biosynthetic process
BME96_01890	COG1304	FMN binding
BME96_01895	COG4876	unkown
BME96_01900	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BME96_01905	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
BME96_01910	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BME96_01915	COG4605	iron ion homeostasis
BME96_01920	COG4604	ABC transporter, ATP-binding protein
BME96_01925	COG4607	ABC-type enterochelin transport system periplasmic component
BME96_01930	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BME96_01935	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BME96_01940	COG0140	phosphoribosyl-ATP diphosphatase activity
BME96_01940	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
BME96_01945	COG0107	imidazoleglycerol-phosphate synthase activity
BME96_01950	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
BME96_01955	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
BME96_01960	COG0131	Imidazoleglycerol-phosphate dehydratase
BME96_01965	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
BME96_01970	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
BME96_01975	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
BME96_01980	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
BME96_01985	COG2832	Protein of unknown function (DUF454)
BME96_01995	COG0812	UDP-N-acetylmuramate dehydrogenase activity
BME96_02000	COG1126	abc transporter atp-binding protein
BME96_02005	COG0765	amino acid transport
BME96_02010	COG0765	amino acid transport
BME96_02020	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
BME96_02025	COG0673	inositol 2-dehydrogenase activity
BME96_02030	COG1876	peptidase activity
BME96_02035	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
BME96_02040	COG2839	Protein conserved in bacteria
BME96_02045	COG0351	phosphomethylpyrimidine kinase
BME96_02050	COG1335	isochorismatase
BME96_02060	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BME96_02070	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BME96_02075	COG0765	amino acid transport
BME96_02080	COG1126	abc transporter atp-binding protein
BME96_02085	COG0714	Associated with various cellular activities
BME96_02090	COG0386	Belongs to the glutathione peroxidase family
BME96_02095	COG3949	Membrane
BME96_02100	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
BME96_02100	COG2508	Transcriptional regulator
BME96_02105	COG0686	Belongs to the AlaDH PNT family
BME96_02125	COG1278	Cold shock
BME96_02130	COG1073	alpha beta
BME96_02130	COG2226	methyltransferase
BME96_02140	COG2084	Dehydrogenase
BME96_02150	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
BME96_02155	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
BME96_02160	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BME96_02165	COG0745	RESPONSE REGULATOR receiver
BME96_02170	COG5002	protein histidine kinase activity
BME96_02170	COG3850	Histidine kinase
BME96_02180	COG1263	PTS System
BME96_02180	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BME96_02185	COG0366	Alpha amylase catalytic
BME96_02190	COG2188	Transcriptional regulator
BME96_02195	COG1834	amidinotransferase
BME96_02200	COG3403	YqcI/YcgG family
BME96_02205	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
BME96_02210	COG1131	(ABC) transporter
BME96_02220	COG2801	Transposase and inactivated derivatives
BME96_02225	COG0183	Belongs to the thiolase family
BME96_02235	COG2843	Capsule synthesis protein
BME96_02245	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BME96_02255	COG0745	RESPONSE REGULATOR receiver
BME96_02260	COG3850	Histidine kinase
BME96_02260	COG5002	protein histidine kinase activity
BME96_02270	COG1597	lipid kinase activity
BME96_02275	COG1846	Transcriptional regulator
BME96_02280	COG0702	epimerase
BME96_02300	COG1307	EDD domain protein, DegV family
BME96_02305	COG0697	spore germination
BME96_02310	COG0513	Belongs to the DEAD box helicase family
BME96_02315	COG0705	Rhomboid family
BME96_02320	COG0736	holo-[acyl-carrier-protein] synthase activity
BME96_02325	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
BME96_02325	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
BME96_02330	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
BME96_02335	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
BME96_02345	COG2337	Toxic component of a toxin-antitoxin (TA) module
BME96_02350	COG1366	Belongs to the anti-sigma-factor antagonist family
BME96_02355	COG1366	Belongs to the anti-sigma-factor antagonist family
BME96_02360	COG2172	sigma factor antagonist activity
BME96_02365	COG2208	phosphoserine phosphatase activity
BME96_02370	COG1366	Belongs to the anti-sigma-factor antagonist family
BME96_02375	COG2172	sigma factor antagonist activity
BME96_02380	COG1191	sigma factor activity
BME96_02385	COG2208	phosphoserine phosphatase activity
BME96_02390	COG2183	response to ionizing radiation
BME96_02395	COG0753	catalase activity
BME96_02400	COG3091	SprT-like family
BME96_02490	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
BME96_02495	COG0802	atpase or kinase
BME96_02500	COG1214	PFAM Peptidase M22, glycoprotease
BME96_02505	COG0456	acetyltransferase
BME96_02510	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
BME96_02515	COG0772	Belongs to the SEDS family
BME96_02520	COG0488	(ABC) transporter
BME96_02530	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
BME96_02540	COG1266	CAAX protease self-immunity
BME96_02545	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
BME96_02550	COG0459	protein refolding
BME96_02555	COG4873	Protein conserved in bacteria
BME96_02565	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
BME96_02570	COG0789	Transcriptional regulator
BME96_02570	COG4978	Transcriptional regulator
BME96_02575	COG0456	acetyltransferase
BME96_02580	COG1309	transcriptional regulator
BME96_02585	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BME96_02590	COG0390	transport system, permease component
BME96_02595	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BME96_02600	COG0745	RESPONSE REGULATOR receiver
BME96_02605	COG2205	protein histidine kinase activity
BME96_02610	COG1136	(ABC) transporter
BME96_02615	COG0577	efflux transmembrane transporter activity
BME96_02625	COG1309	transcriptional regulator
BME96_02635	COG0668	transmembrane transport
BME96_02640	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
BME96_02645	COG0697	spore germination
BME96_02650	COG0531	amino acid
BME96_02665	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
BME96_02685	COG3729	General stress protein
BME96_02690	COG0714	Associated with various cellular activities
BME96_02695	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
BME96_02700	COG1305	Transglutaminase-like
BME96_02705	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BME96_02705	COG0519	Catalyzes the synthesis of GMP from XMP
BME96_02710	COG2252	PERMEase
BME96_02720	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BME96_02725	COG2258	MOSC domain
BME96_02735	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
BME96_02740	COG0519	Catalyzes the synthesis of GMP from XMP
BME96_02745	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
BME96_02750	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
BME96_02755	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
BME96_02760	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
BME96_02765	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BME96_02770	COG0047	phosphoribosylformylglycinamidine synthase activity
BME96_02775	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BME96_02780	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
BME96_02785	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
BME96_02790	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
BME96_02795	COG0138	bifunctional purine biosynthesis protein purh
BME96_02800	COG0151	Belongs to the GarS family
BME96_02805	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
BME96_02810	COG1470	cell adhesion involved in biofilm formation
BME96_02815	COG4496	protein, YerC YecD
BME96_02820	COG0084	hydrolase, TatD family'
BME96_02825	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
BME96_02830	COG0210	DNA helicase
BME96_02835	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
BME96_02840	COG4851	CamS sex pheromone cAM373 precursor
BME96_02845	COG1012	belongs to the aldehyde dehydrogenase family
BME96_02860	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BME96_02865	COG0154	amidase activity
BME96_02870	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BME96_02875	COG1597	lipid kinase activity
BME96_02880	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BME96_02885	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BME96_02890	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BME96_02900	COG0109	protoheme IX farnesyltransferase activity
BME96_02915	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
BME96_02925	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BME96_02935	COG4499	WXG100 protein secretion system (Wss), protein YukC
BME96_02935	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BME96_02940	COG1278	Cold shock
BME96_02945	COG0697	spore germination
BME96_02950	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BME96_02955	COG0109	protoheme IX farnesyltransferase activity
BME96_02965	COG0166	Belongs to the GPI family
BME96_02975	COG0778	Nitroreductase
BME96_02980	COG0564	pseudouridine synthase activity
BME96_02990	COG1785	Belongs to the alkaline phosphatase family
BME96_02995	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BME96_03000	COG0488	(ABC) transporter
BME96_03030	COG0733	neurotransmitter:sodium symporter activity
BME96_03035	COG1757	Na H antiporter
BME96_03040	COG0436	Aminotransferase
BME96_03045	COG0028	Belongs to the TPP enzyme family
BME96_03050	COG1012	belongs to the aldehyde dehydrogenase family
BME96_03060	COG1414	Transcriptional regulator
BME96_03070	COG1012	belongs to the aldehyde dehydrogenase family
BME96_03080	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BME96_03085	COG1077	Cell shape determining protein MreB Mrl
BME96_03090	COG2340	Cysteine-rich secretory protein family
BME96_03095	COG2066	Belongs to the glutaminase family
BME96_03100	COG2135	peptidase activity
BME96_03105	COG1115	amino acid carrier protein
BME96_03115	COG1295	ribonuclease BN
BME96_03120	COG2217	Heavy metal translocating P-type atpase
BME96_03125	COG0477	Major facilitator Superfamily
BME96_03140	COG2056	Na+-H+ antiporter family
BME96_03150	COG5001	Diguanylate cyclase
BME96_03150	COG3300	MHYT domain
BME96_03160	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BME96_03165	COG0542	response to heat
BME96_03170	COG0658	competence protein
BME96_03170	COG2333	competence protein COMEC
BME96_03175	COG2186	Transcriptional regulator
BME96_03180	COG1131	(ABC) transporter
BME96_03190	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
BME96_03195	COG1131	(ABC) transporter
BME96_03200	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BME96_03210	COG2188	Transcriptional regulator
BME96_03230	COG1090	epimerase
BME96_03235	COG2137	regulation of response to DNA damage stimulus
BME96_03250	COG1988	membrane-bound metal-dependent
BME96_03255	COG1194	a g-specific adenine glycosylase
BME96_03265	COG3557	Belongs to the UPF0374 family
BME96_03270	COG1132	(ABC) transporter
BME96_03275	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
BME96_03285	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
BME96_03290	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
BME96_03295	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BME96_03300	COG0735	belongs to the Fur family
BME96_03310	COG0512	Glutamine amidotransferase of anthranilate synthase
BME96_03420	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
BME96_03440	COG0424	maF-like protein
BME96_03450	COG1733	regulation of RNA biosynthetic process
BME96_03460	COG0431	NADPH-dependent FMN reductase
BME96_03465	COG2986	histidine ammonia-lyase
BME96_03470	COG2364	Membrane
BME96_03480	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BME96_03490	COG1227	inorganic diphosphatase activity
BME96_03515	COG4474	Belongs to the UPF0398 family
BME96_03545	COG0456	acetyltransferase
BME96_03550	COG1794	racemase activity, acting on amino acids and derivatives
BME96_03570	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BME96_03605	COG4842	Belongs to the WXG100 family
BME96_03610	COG5417	Belongs to the EsaB family
BME96_03615	COG4499	WXG100 protein secretion system (Wss), protein YukC
BME96_03620	COG1674	ftsk spoiiie
BME96_03620	COG0433	COG0433 Predicted ATPase
BME96_03625	COG1511	domain protein
BME96_03645	COG5444	nuclease activity
BME96_03665	COG5444	nuclease activity
BME96_03735	COG2814	Major facilitator Superfamily
BME96_03740	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
BME96_03745	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
BME96_03750	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BME96_03765	COG4166	transmembrane transport
BME96_03770	COG0277	FAD linked oxidase domain protein
BME96_03785	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BME96_03795	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BME96_03810	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
BME96_03830	COG1714	RDD family
BME96_03835	COG2176	DNA-directed DNA polymerase activity
BME96_03840	COG0616	signal peptide processing
BME96_03845	COG1714	RDD family
BME96_03850	COG0318	PFAM AMP-dependent synthetase and ligase
BME96_03880	COG2233	PERMEase
BME96_03885	COG2814	Major facilitator Superfamily
BME96_03890	COG0697	spore germination
BME96_03905	COG0604	alcohol dehydrogenase
BME96_03915	COG3320	Male sterility
BME96_03915	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BME96_03940	COG2318	DinB family
BME96_03950	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
BME96_03955	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
BME96_03960	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
BME96_03965	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BME96_03970	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BME96_03975	COG4946	Tricorn protease homolog
BME96_03975	COG1506	peptidase
BME96_03975	COG0823	Involved in the tonB-independent uptake of proteins
BME96_03980	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
BME96_04005	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
BME96_04010	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
BME96_04025	COG0567	Dehydrogenase, E1 component
BME96_04030	COG0508	dehydrogenase complex catalyzes the overall conversion of
BME96_04035	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
BME96_04040	COG1012	belongs to the aldehyde dehydrogenase family
BME96_04045	COG0534	Mate efflux family protein
BME96_04050	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
BME96_04070	COG0288	reversible hydration of carbon dioxide
BME96_04080	COG1132	(ABC) transporter
BME96_04085	COG1132	(ABC) transporter
BME96_04090	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BME96_04105	COG1191	sigma factor activity
BME96_04125	COG1854	S-ribosylhomocysteine lyase activity
BME96_04130	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BME96_04135	COG0626	cystathionine gamma-synthase activity
BME96_04140	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BME96_04145	COG1028	Short-chain dehydrogenase reductase Sdr
BME96_04155	COG1131	(ABC) transporter
BME96_04160	COG0024	Methionine aminopeptidase
BME96_04175	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
BME96_04185	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
BME96_04195	COG2270	Major facilitator Superfamily
BME96_04205	COG0114	fumarate hydratase activity
BME96_04215	COG3842	ATPase activity
BME96_04220	COG2508	Transcriptional regulator
BME96_04225	COG3679	Belongs to the UPF0342 family
BME96_04230	COG1024	Enoyl-CoA hydratase
BME96_04240	COG4152	abc transporter atp-binding protein
BME96_04245	COG1668	transmembrane transport
BME96_04250	COG0420	3'-5' exonuclease activity
BME96_04255	COG4717	serine-type aminopeptidase activity
BME96_04260	COG1510	regulation of RNA biosynthetic process
BME96_04265	COG3481	metal-dependent phosphohydrolase, HD sub domain
BME96_04275	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BME96_04295	COG1510	regulation of RNA biosynthetic process
BME96_04320	COG4980	gas vesicle protein
BME96_04330	COG0537	adenosine 5'-monophosphoramidase activity
BME96_04335	COG1131	(ABC) transporter
BME96_04340	COG4473	ABC transporter
BME96_04345	COG1473	amidohydrolase
BME96_04350	COG2193	ferroxidase activity
BME96_04360	COG2814	Major facilitator Superfamily
BME96_04370	COG4585	Histidine kinase
BME96_04375	COG2197	response regulator
BME96_04380	COG2801	Transposase and inactivated derivatives
BME96_04395	COG2329	Antibiotic biosynthesis monooxygenase
BME96_04400	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BME96_04405	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
BME96_04420	COG1164	Oligoendopeptidase f
BME96_04435	COG1234	tRNA 3'-trailer cleavage
BME96_04440	COG0095	Lipoate-protein ligase
BME96_04445	COG0318	PFAM AMP-dependent synthetase and ligase
BME96_04455	COG0398	Pfam SNARE associated Golgi protein
BME96_04465	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
BME96_04470	COG1074	ATP-dependent DNA helicase activity
BME96_04475	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
BME96_04480	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BME96_04525	COG2311	Membrane
BME96_04530	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BME96_04550	COG1028	Short-chain dehydrogenase reductase Sdr
BME96_04560	COG1307	EDD domain protein, DegV family
BME96_04565	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BME96_04585	COG0561	phosphatase activity
BME96_04590	COG1073	alpha beta
BME96_04595	COG2151	metal-sulfur cluster biosynthetic enzyme
BME96_04605	COG0314	molybdopterin synthase activity
BME96_04615	COG2151	metal-sulfur cluster biosynthetic enzyme
BME96_04650	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BME96_04675	COG1744	ABC transporter substrate-binding protein PnrA-like
BME96_04680	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BME96_04685	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BME96_04700	COG0180	Tryptophanyl-tRNA synthetase
BME96_04715	COG1388	LysM domain
BME96_04725	COG0456	acetyltransferase
BME96_04730	COG3258	Cytochrome c
BME96_04735	COG1393	Belongs to the ArsC family
BME96_04740	COG4862	establishment of competence for transformation
BME96_04750	COG1164	Oligoendopeptidase f
BME96_04760	COG2346	COG2346, Truncated hemoglobins
BME96_04765	COG4116	CYTH
BME96_04770	COG2357	RelA SpoT domain protein
BME96_04775	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
BME96_04780	COG0564	pseudouridine synthase activity
BME96_04785	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
BME96_04790	COG2239	Acts as a magnesium transporter
BME96_04820	COG2323	membrane
BME96_04825	COG2153	protein acetylation
BME96_04830	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
BME96_04835	COG2382	esterase
BME96_04840	COG1132	(ABC) transporter
BME96_04845	COG1132	(ABC) transporter
BME96_04890	COG0436	Aminotransferase
BME96_04895	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BME96_04900	COG2011	ABC-type metal ion transport system permease component
BME96_04905	COG1464	Belongs to the NlpA lipoprotein family
BME96_04935	COG0584	glycerophosphoryl diester phosphodiesterase
BME96_04975	COG1360	Flagellar Motor Protein
BME96_04990	COG0488	(ABC) transporter
BME96_05010	COG0584	glycerophosphoryl diester phosphodiesterase
BME96_05015	COG2130	NADP-dependent
BME96_05025	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BME96_05030	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BME96_05040	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BME96_05055	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
BME96_05060	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
BME96_05065	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
BME96_05070	COG0297	glycogen (starch) synthase activity
BME96_05075	COG0697	spore germination
BME96_05080	COG0814	amino acid
BME96_05115	COG0579	oxidoreductase
BME96_05175	COG4974	Belongs to the 'phage' integrase family
BME96_05200	COG2258	MOSC domain
BME96_05220	COG0586	Pfam SNARE associated Golgi protein
BME96_05230	COG1714	RDD family
BME96_05245	COG0596	Alpha beta hydrolase
BME96_05280	COG1051	belongs to the nudix hydrolase family
BME96_05305	COG1064	alcohol dehydrogenase
BME96_05310	COG1525	nuclease
BME96_05320	COG0662	Cupin 2, conserved barrel domain protein
BME96_05330	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
BME96_05330	COG0456	acetyltransferase
BME96_05385	COG1131	(ABC) transporter
BME96_05395	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BME96_05400	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BME96_05405	COG1120	ATPase activity
BME96_05410	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
BME96_05415	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BME96_05425	COG1492	cobalamin metabolic process
BME96_05430	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
BME96_05435	COG0588	phosphoglycerate mutase activity
BME96_05445	COG2096	Adenosyltransferase
BME96_05475	COG1473	amidohydrolase
BME96_05500	COG0653	protein targeting
BME96_05515	COG0477	Major facilitator Superfamily
BME96_05605	COG2267	carboxylic ester hydrolase activity
BME96_05625	COG2816	NAD+ diphosphatase activity
BME96_05650	COG0596	Alpha beta hydrolase
BME96_05715	COG3961	Belongs to the TPP enzyme family
BME96_05720	COG1846	Transcriptional regulator
BME96_05735	COG0346	lactoylglutathione lyase activity
BME96_05775	COG0789	Transcriptional regulator
BME96_05775	COG4978	Transcriptional regulator
BME96_05780	COG1266	CAAX protease self-immunity
BME96_05800	COG2226	methyltransferase
BME96_05810	COG0024	Methionine aminopeptidase
BME96_05840	COG0745	RESPONSE REGULATOR receiver
BME96_05855	COG2205	protein histidine kinase activity
BME96_05880	COG2353	YceI-like domain
BME96_05890	COG0346	lactoylglutathione lyase activity
BME96_05895	COG0346	lactoylglutathione lyase activity
BME96_05900	COG1846	Transcriptional regulator
BME96_05920	COG0456	acetyltransferase
BME96_05970	COG1247	-acetyltransferase
BME96_05975	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
BME96_05980	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
BME96_05985	COG2376	Dihydroxyacetone kinase
BME96_05990	COG1461	Dihydroxyacetone kinase
BME96_06035	COG3279	Response regulator of the LytR AlgR family
BME96_06040	COG0110	maltose O-acetyltransferase activity
BME96_06045	COG1695	Transcriptional regulator
BME96_06055	COG0535	radical SAM domain protein
BME96_06065	COG2169	Transcriptional regulator
BME96_06070	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
BME96_06075	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
BME96_06085	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
BME96_06110	COG2031	fatty acid transporter
BME96_06120	COG0842	Transport permease protein
BME96_06120	COG1129	ABC transporter
BME96_06175	COG1201	RNA secondary structure unwinding
BME96_06180	COG3586	endonuclease activity
BME96_06185	COG0494	nUDIX hydrolase
BME96_06195	COG1061	Type III restriction enzyme res subunit
BME96_06210	COG1012	belongs to the aldehyde dehydrogenase family
BME96_06235	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BME96_06340	COG3655	Transcriptional regulator
BME96_06345	COG3739	integral membrane protein
BME96_06375	COG0406	alpha-ribazole phosphatase activity
BME96_06380	COG0842	Transport permease protein
BME96_06385	COG1131	(ABC) transporter
BME96_06390	COG1619	proteins homologs of microcin C7 resistance protein MccF
BME96_06430	COG3588	fructose-bisphosphate aldolase
BME96_06440	COG0179	Fumarylacetoacetate (FAA) hydrolase
BME96_06450	COG4443	Transcriptional Coactivator p15 (PC4)
BME96_06490	COG1098	S1 RNA binding domain
BME96_06495	COG2112	serine threonine protein kinase
BME96_06500	COG1012	belongs to the aldehyde dehydrogenase family
BME96_06510	COG3844	kynureninase activity
BME96_06515	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
BME96_06525	COG0733	neurotransmitter:sodium symporter activity
BME96_06530	COG0745	RESPONSE REGULATOR receiver
BME96_06545	COG0501	Belongs to the peptidase M48B family
BME96_06570	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
BME96_06575	COG0456	acetyltransferase
BME96_06575	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
BME96_06600	COG0667	Aldo Keto reductase
BME96_06610	COG2322	membrane
BME96_06615	COG2226	methyltransferase
BME96_06625	COG2267	carboxylic ester hydrolase activity
BME96_06655	COG1366	Belongs to the anti-sigma-factor antagonist family
BME96_06665	COG1309	transcriptional regulator
BME96_06670	COG2814	Major facilitator Superfamily
BME96_06675	COG2217	Heavy metal translocating P-type atpase
BME96_06690	COG0739	heme binding
BME96_06690	COG1196	nuclear chromosome segregation
BME96_06690	COG0741	lytic transglycosylase activity
BME96_06695	COG2323	membrane
BME96_06715	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BME96_06730	COG1063	alcohol dehydrogenase
BME96_06775	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
BME96_06780	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
BME96_06785	COG1368	sulfuric ester hydrolase activity
BME96_06790	COG0640	Transcriptional regulator
BME96_06795	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
BME96_06800	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BME96_06810	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
BME96_06835	COG0598	Magnesium transport protein CorA
BME96_06845	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BME96_06845	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BME96_06850	COG0307	riboflavin synthase, alpha
BME96_06855	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BME96_06855	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BME96_06860	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
BME96_06885	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
BME96_06890	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BME96_06920	COG5002	protein histidine kinase activity
BME96_06925	COG0745	RESPONSE REGULATOR receiver
BME96_06935	COG2132	Multicopper oxidase
BME96_06940	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
BME96_06945	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BME96_06950	COG0446	pyridine nucleotide-disulphide oxidoreductase
BME96_06965	COG1533	DNA photolyase activity
BME96_07050	COG3311	Transcriptional regulator
BME96_07055	COG0659	secondary active sulfate transmembrane transporter activity
BME96_07065	COG4990	cell redox homeostasis
BME96_07080	COG2329	Antibiotic biosynthesis monooxygenase
BME96_07085	COG2202	Pas domain
BME96_07085	COG1366	Belongs to the anti-sigma-factor antagonist family
BME96_07105	COG1228	amidohydrolase
BME96_07110	COG0530	calcium, potassium:sodium antiporter activity
BME96_07115	COG2314	TM2 domain
BME96_07120	COG1615	UPF0182 protein
BME96_07135	COG5504	Zn-dependent protease
BME96_07155	COG3104	oligopeptide transport
BME96_07185	COG4294	response to UV
BME96_07190	COG0517	IMP dehydrogenase activity
BME96_07210	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
BME96_07220	COG2081	HI0933 family
BME96_07225	COG2244	polysaccharide biosynthetic process
BME96_07230	COG1187	pseudouridine synthase activity
BME96_07235	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
BME96_07245	COG0510	thiamine kinase activity
BME96_07255	COG0220	tRNA (guanine-N7-)-methyltransferase activity
BME96_07260	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BME96_07270	COG1363	Peptidase, m42
BME96_07275	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
BME96_07285	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BME96_07290	COG4848	Belongs to the UPF0354 family
BME96_07295	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BME96_07300	COG1674	ftsk spoiiie
BME96_07310	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BME96_07320	COG4980	gas vesicle protein
BME96_07325	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
BME96_07325	COG1605	Chorismate mutase
BME96_07345	COG0123	including yeast histone deacetylase and acetoin utilization protein
BME96_07350	COG0517	IMP dehydrogenase activity
BME96_07355	COG0454	-acetyltransferase
BME96_07360	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BME96_07365	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
BME96_07370	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
BME96_07375	COG2199	diguanylate cyclase activity
BME96_07375	COG2203	Gaf domain
BME96_07380	COG1956	GAF domain-containing protein
BME96_07385	COG1309	transcriptional regulator
BME96_07390	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
BME96_07395	COG1104	cysteine desulfurase activity
BME96_07400	COG0301	tRNA thio-modification
BME96_07410	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
BME96_07420	COG3874	Sporulation protein YtfJ
BME96_07425	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
BME96_07430	COG0827	DNA restriction-modification system
BME96_07435	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
BME96_07440	COG0521	Mo-molybdopterin cofactor biosynthetic process
BME96_07445	COG0589	response to stress
BME96_07455	COG1842	Phage shock protein A
BME96_07470	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
BME96_07475	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
BME96_07495	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BME96_07505	COG1459	type II secretion system
BME96_07515	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
BME96_07540	COG4109	DRTGG domain
BME96_07550	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
BME96_07570	COG0587	DNA-directed DNA polymerase activity
BME96_07575	COG0281	malic enzyme
BME96_07580	COG2186	Transcriptional regulator
BME96_07585	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
BME96_07590	COG0825	malonyl-CoA metabolic process
BME96_07595	COG0205	6-phosphofructokinase activity
BME96_07605	COG3030	protein affecting phage T7 exclusion by the F plasmid
BME96_07610	COG0628	permease
BME96_07615	COG0372	Belongs to the citrate synthase family
BME96_07620	COG0538	isocitrate dehydrogenase activity
BME96_07625	COG0039	L-malate dehydrogenase activity
BME96_07635	COG0745	RESPONSE REGULATOR receiver
BME96_07640	COG5002	protein histidine kinase activity
BME96_07645	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BME96_07645	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BME96_07650	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
BME96_07655	COG0237	dephospho-CoA kinase activity
BME96_07660	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BME96_07665	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
BME96_07675	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
BME96_07680	COG3611	Membrane attachment protein
BME96_07685	COG1484	DNA-dependent DNA replication
BME96_07695	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BME96_07700	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
BME96_07705	COG0291	Belongs to the bacterial ribosomal protein bL35 family
BME96_07710	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
BME96_07715	COG3326	Membrane
BME96_07720	COG0398	Pfam SNARE associated Golgi protein
BME96_07735	COG1363	Peptidase, m42
BME96_07740	COG0741	lytic transglycosylase activity
BME96_07745	COG1131	(ABC) transporter
BME96_07770	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BME96_07775	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
BME96_07780	COG0072	phenylalanine-tRNA ligase activity
BME96_07780	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BME96_07785	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
BME96_07790	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
BME96_07795	COG1286	toxin biosynthetic process
BME96_07800	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
BME96_07800	COG1796	DNA polymerase
BME96_07805	COG1193	negative regulation of DNA recombination
BME96_07810	COG3766	membrane
BME96_07815	COG0318	PFAM AMP-dependent synthetase and ligase
BME96_07820	COG1309	transcriptional regulator
BME96_07825	COG1024	Enoyl-CoA hydratase
BME96_07830	COG2086	electron transfer activity
BME96_07835	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
BME96_07840	COG3118	belongs to the thioredoxin family
BME96_07845	COG0322	excinuclease ABC activity
BME96_07850	COG1719	4-vinyl reductase, 4VR
BME96_07855	COG2009	succinate dehydrogenase
BME96_07860	COG1053	succinate dehydrogenase
BME96_07865	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
BME96_07870	COG0824	Thioesterase
BME96_07875	COG2197	response regulator
BME96_07880	COG1846	Transcriptional regulator
BME96_07885	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
BME96_07890	COG5401	PFAM Sporulation and spore germination
BME96_07895	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
BME96_07900	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
BME96_07905	COG0622	Phosphoesterase
BME96_07930	COG0544	peptidyl-prolyl cis-trans isomerase activity
BME96_07935	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
BME96_07945	COG0218	Necessary for normal cell division and for the maintenance of normal septation
BME96_07950	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BME96_07955	COG0765	amino acid transport
BME96_07970	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
BME96_07975	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BME96_07980	COG0181	hydroxymethylbilane synthase activity
BME96_07990	COG0113	porphobilinogen synthase activity
BME96_07995	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
BME96_08000	COG1388	LysM domain
BME96_08000	COG1388	LysM domain
BME96_08015	COG0525	valine-tRNA ligase activity
BME96_08030	COG0285	dihydrofolate synthase activity
BME96_08040	COG2003	Belongs to the UPF0758 family
BME96_08070	COG1077	Cell shape determining protein MreB Mrl
BME96_08075	COG1792	Involved in formation and maintenance of cell shape
BME96_08085	COG0850	regulation of cytokinetic process
BME96_08090	COG2894	cell division
BME96_08100	COG1994	Peptidase M50
BME96_08105	COG0261	This protein binds to 23S rRNA in the presence of protein L20
BME96_08110	COG2868	ribosomal protein
BME96_08125	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
BME96_08130	COG0077	Prephenate dehydratase
BME96_08135	COG1388	LysM domain
BME96_08145	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
BME96_08155	COG0217	transcriptional regulatory protein
BME96_08160	COG0632	four-way junction helicase activity
BME96_08165	COG2255	four-way junction helicase activity
BME96_08175	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
BME96_08180	COG0343	queuine tRNA-ribosyltransferase activity
BME96_08185	COG1862	Preprotein translocase
BME96_08195	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
BME96_08205	COG2244	polysaccharide biosynthetic process
BME96_08215	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BME96_08215	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BME96_08220	COG5416	Lipopolysaccharide assembly protein A domain
BME96_08225	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
BME96_08225	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
BME96_08230	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BME96_08235	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BME96_08240	COG1490	D-aminoacyl-tRNA deacylase activity
BME96_08245	COG0860	N-Acetylmuramoyl-L-alanine amidase
BME96_08245	COG3103	Sh3 type 3 domain protein
BME96_08245	COG4991	sh3 domain protein
BME96_08250	COG0124	histidyl-tRNA synthetase
BME96_08255	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
BME96_08270	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
BME96_08275	COG1959	2 iron, 2 sulfur cluster binding
BME96_08280	COG1104	cysteine desulfurase activity
BME96_08285	COG0482	sulfurtransferase activity
BME96_08295	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BME96_08305	COG0628	permease
BME96_08310	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BME96_08315	COG4472	Bacterial protein of unknown function (DUF965)
BME96_08320	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
BME96_08325	COG3906	Belongs to the UPF0473 family
BME96_08330	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
BME96_08340	COG0572	uridine kinase
BME96_08345	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BME96_08355	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
BME96_08365	COG1191	sigma factor activity
BME96_08375	COG2212	antiporter activity
BME96_08385	COG0651	ATP synthesis coupled electron transport
BME96_08395	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BME96_08395	COG2111	Na H antiporter
BME96_08405	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
BME96_08410	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
BME96_08415	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
BME96_08420	COG1534	Rna-binding protein
BME96_08425	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
BME96_08430	COG1713	HD superfamily hydrolase involved in NAD metabolism
BME96_08435	COG0799	negative regulation of ribosome biogenesis
BME96_08440	COG2226	methyltransferase
BME96_08445	COG1596	polysaccharide export
BME96_08445	COG1555	photosystem II stabilization
BME96_08450	COG2131	deaminase
BME96_08455	COG0658	competence protein
BME96_08455	COG2333	competence protein COMEC
BME96_08460	COG1466	dna polymerase III delta subunit
BME96_08465	COG0268	Binds directly to 16S ribosomal RNA
BME96_08470	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
BME96_08475	COG0860	N-Acetylmuramoyl-L-alanine amidase
BME96_08485	COG0481	GTPase activity
BME96_08490	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BME96_08495	COG1420	regulation of RNA biosynthetic process
BME96_08500	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
BME96_08505	COG0443	Heat shock 70 kDa protein
BME96_08510	COG0484	heat shock protein binding
BME96_08515	COG2264	protein methyltransferase activity
BME96_08520	COG1385	rRNA (uridine-N3-)-methyltransferase activity
BME96_08525	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BME96_08530	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
BME96_08535	COG0828	Belongs to the bacterial ribosomal protein bS21 family
BME96_08540	COG1610	YqeY-like protein
BME96_08545	COG1030	water channel activity
BME96_08550	COG4864	UPF0365 protein
BME96_08570	COG1702	phosphate starvation-inducible protein PhoH
BME96_08575	COG1480	7TM receptor with intracellular HD hydrolase
BME96_08580	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
BME96_08590	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
BME96_08595	COG1381	Involved in DNA repair and RecF pathway recombination
BME96_08600	COG0752	glycyl-tRNA synthetase alpha subunit
BME96_08605	COG0751	glycine-tRNA ligase activity
BME96_08610	COG0517	IMP dehydrogenase activity
BME96_08615	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
BME96_08620	COG0358	DNA primase activity
BME96_08625	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BME96_08640	COG2384	SAM-dependent methyltransferase
BME96_08645	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
BME96_08655	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
BME96_08665	COG4709	membrane
BME96_08680	COG0704	Plays a role in the regulation of phosphate uptake
BME96_08715	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
BME96_08720	COG0477	Major facilitator Superfamily
BME96_08730	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
BME96_08740	COG0267	Belongs to the bacterial ribosomal protein bL33 family
BME96_08745	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
BME96_08750	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
BME96_08760	COG0457	Tetratricopeptide repeat
BME96_08760	COG0705	Rhomboid family
BME96_08770	COG0697	spore germination
BME96_08780	COG1940	carbohydrate kinase activity
BME96_08790	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BME96_08825	COG4537	Required for transformation and DNA binding
BME96_08900	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
BME96_08925	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
BME96_08930	COG0582	viral genome integration into host DNA
BME96_08970	COG0740	serine-type endopeptidase activity
BME96_09055	COG1876	peptidase activity
BME96_09105	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BME96_09110	COG0404	The glycine cleavage system catalyzes the degradation of glycine
BME96_09115	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BME96_09120	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BME96_09125	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BME96_09130	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BME96_09135	COG1321	iron dependent repressor
BME96_09140	COG1752	Esterase of the alpha-beta hydrolase superfamily
BME96_09155	COG0006	proline dipeptidase activity
BME96_09160	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BME96_09165	COG3854	ATPases associated with a variety of cellular activities
BME96_09205	COG0511	ligase activity, forming carbon-carbon bonds
BME96_09210	COG0439	Biotin carboxylase
BME96_09215	COG1302	Protein conserved in bacteria
BME96_09220	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BME96_09225	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
BME96_09230	COG1570	exodeoxyribonuclease VII activity
BME96_09235	COG1722	exodeoxyribonuclease VII activity
BME96_09250	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
BME96_09255	COG1438	arginine binding
BME96_09260	COG0497	DNA recombination
BME96_09265	COG0750	zinc metalloprotease
BME96_09270	COG0745	RESPONSE REGULATOR receiver
BME96_09275	COG0527	aspartate kinase activity
BME96_09285	COG3829	transcription factor binding
BME96_09285	COG3290	protein histidine kinase activity
BME96_09290	COG0280	phosphate acetyltransferase
BME96_09305	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BME96_09310	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
BME96_09315	COG0022	dehydrogenase e1 component
BME96_09320	COG0508	dehydrogenase complex catalyzes the overall conversion of
BME96_09330	COG4129	membrane
BME96_09340	COG0346	lactoylglutathione lyase activity
BME96_09345	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BME96_09350	COG2195	Cleaves the N-terminal amino acid of tripeptides
BME96_09360	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BME96_09365	COG1012	belongs to the aldehyde dehydrogenase family
BME96_09370	COG1234	tRNA 3'-trailer cleavage
BME96_09375	COG1902	pentaerythritol trinitrate reductase activity
BME96_09380	COG0584	glycerophosphoryl diester phosphodiesterase
BME96_09385	COG4187	Peptidase family M20/M25/M40
BME96_09390	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BME96_09395	COG0300	oxidoreductase activity
BME96_09405	COG0667	Aldo Keto reductase
BME96_09415	COG1379	DNA repair
BME96_09420	COG1300	Membrane
BME96_09425	COG0735	belongs to the Fur family
BME96_09435	COG4974	Belongs to the 'phage' integrase family
BME96_09440	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
BME96_09455	COG1686	Belongs to the peptidase S11 family
BME96_09460	COG1366	Belongs to the anti-sigma-factor antagonist family
BME96_09465	COG2172	sigma factor antagonist activity
BME96_09485	COG0697	spore germination
BME96_09490	COG0019	diaminopimelate decarboxylase activity
BME96_09495	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BME96_09505	COG0456	acetyltransferase
BME96_09515	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
BME96_09520	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
BME96_09525	COG1686	Belongs to the peptidase S11 family
BME96_09530	COG2715	membrane protein required for spore maturation
BME96_09535	COG0700	Nucleoside recognition
BME96_09540	COG1187	pseudouridine synthase activity
BME96_09545	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BME96_09550	COG1333	cytochrome c biogenesis protein
BME96_09555	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BME96_09560	COG0745	RESPONSE REGULATOR receiver
BME96_09565	COG5002	protein histidine kinase activity
BME96_09575	COG1141	Ferredoxin
BME96_09580	COG4955	Helix-turn-helix domain
BME96_09585	COG0514	ATP-dependent DNA helicase (RecQ)
BME96_09590	COG1266	CAAX protease self-immunity
BME96_09600	COG1408	metallophosphoesterase
BME96_09605	COG4862	establishment of competence for transformation
BME96_09610	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BME96_09615	COG0492	ferredoxin-NADP+ reductase activity
BME96_09620	COG0252	asparaginase activity
BME96_09625	COG2339	peptidase activity
BME96_09630	COG3773	Cell wall hydrolase
BME96_09630	COG3409	Peptidoglycan-binding domain 1 protein
BME96_09635	COG2959	enzyme of heme biosynthesis
BME96_09645	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
BME96_09655	COG0539	negative regulation of cytoplasmic translation
BME96_09675	COG1160	GTP binding
BME96_09680	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
BME96_09700	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
BME96_09705	COG0776	regulation of translation
BME96_09715	COG0142	geranyltranstransferase activity
BME96_09720	COG2226	methyltransferase
BME96_09725	COG0142	geranyltranstransferase activity
BME96_09730	COG0105	UTP biosynthetic process
BME96_09735	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
BME96_09740	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
BME96_09745	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
BME96_09750	COG4401	Chorismate mutase type I
BME96_09755	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BME96_09760	COG0287	Prephenate dehydrogenase
BME96_09765	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
BME96_09770	COG0457	Tetratricopeptide repeat
BME96_09775	COG5582	Belongs to the UPF0302 family
BME96_09785	COG0723	plastoquinol--plastocyanin reductase activity
BME96_09790	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
BME96_09800	COG4347	Protein of unknown function (DUF1405)
BME96_09810	COG2738	Putative neutral zinc metallopeptidase
BME96_09815	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BME96_09820	COG1694	Mazg nucleotide pyrophosphohydrolase
BME96_09825	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
BME96_09830	COG1803	Methylglyoxal synthase
BME96_09835	COG0438	transferase activity, transferring glycosyl groups
BME96_09840	COG0617	tRNA 3'-terminal CCA addition
BME96_09855	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
BME96_09860	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
BME96_09865	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BME96_09865	COG1199	ATP-dependent helicase activity
BME96_09880	COG0436	Aminotransferase
BME96_09885	COG0017	Asparaginyl-tRNA synthetase
BME96_09890	COG3935	DnaD domain protein
BME96_09895	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
BME96_09900	COG4499	WXG100 protein secretion system (Wss), protein YukC
BME96_09900	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BME96_09905	COG3331	DNA recombination
BME96_09925	COG0295	cytidine deaminase activity
BME96_09930	COG3599	regulation of cell shape
BME96_09940	COG0116	Belongs to the methyltransferase superfamily
BME96_09945	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
BME96_09950	COG3424	synthase
BME96_09955	COG1755	Isoprenylcysteine carboxyl methyltransferase
BME96_09960	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BME96_09965	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
BME96_09980	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
BME96_09985	COG1278	Cold shock
BME96_09995	COG1418	mRNA catabolic process
BME96_10000	COG0791	NLP P60 protein
BME96_10000	COG1388	LysM domain
BME96_10005	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
BME96_10010	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
BME96_10015	COG0746	molybdenum cofactor guanylyltransferase activity
BME96_10020	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BME96_10025	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BME96_10030	COG0805	protein transport
BME96_10035	COG4479	Belongs to the UPF0346 family
BME96_10050	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BME96_10050	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BME96_10070	COG1254	Belongs to the acylphosphatase family
BME96_10090	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
BME96_10095	COG1140	nitrate reductase beta subunit
BME96_10105	COG2181	nitrate reductase activity
BME96_10110	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BME96_10110	COG0723	plastoquinol--plastocyanin reductase activity
BME96_10120	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BME96_10125	COG0723	plastoquinol--plastocyanin reductase activity
BME96_10125	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BME96_10130	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BME96_10135	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
BME96_10140	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
BME96_10145	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BME96_10150	COG1024	Enoyl-CoA hydratase
BME96_10155	COG0511	ligase activity, forming carbon-carbon bonds
BME96_10160	COG0439	Biotin carboxylase
BME96_10165	COG0318	PFAM AMP-dependent synthetase and ligase
BME96_10170	COG1960	acyl-CoA dehydrogenase activity
BME96_10175	COG1309	transcriptional regulator
BME96_10180	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BME96_10185	COG0187	DNA topoisomerase II activity
BME96_10190	COG1832	CoA-binding protein
BME96_10195	COG1174	glycine betaine transport
BME96_10205	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
BME96_10210	COG1469	GTP cyclohydrolase I activity
BME96_10215	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
BME96_10225	COG0824	Thioesterase
BME96_10235	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BME96_10240	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
BME96_10245	COG4191	Histidine kinase
BME96_10255	COG4846	Membrane protein involved in cytochrome C biogenesis
BME96_10260	COG2201	protein-glutamate methylesterase activity
BME96_10265	COG2111	Na H antiporter
BME96_10270	COG0785	Cytochrome C biogenesis protein
BME96_10275	COG3763	UPF0154 protein
BME96_10290	COG4224	UPF0291 protein
BME96_10295	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
BME96_10300	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
BME96_10305	COG0174	glutamine synthetase
BME96_10310	COG0789	Transcriptional regulator
BME96_10315	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
BME96_10320	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BME96_10325	COG0464	growth
BME96_10330	COG1923	regulation of RNA biosynthetic process
BME96_10335	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
BME96_10340	COG0783	Belongs to the Dps family
BME96_10345	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
BME96_10350	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
BME96_10360	COG1943	Transposase
BME96_10370	COG4550	Control of competence regulator ComK, YlbF/YmcA
BME96_10375	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BME96_10380	COG2359	stage V sporulation protein S
BME96_10385	COG1692	metallophosphoesterase
BME96_10390	COG1418	mRNA catabolic process
BME96_10395	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
BME96_10400	COG1058	Belongs to the CinA family
BME96_10400	COG1546	Belongs to the CinA family
BME96_10405	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BME96_10410	COG1426	Protein conserved in bacteria
BME96_10425	COG0300	oxidoreductase activity
BME96_10430	COG0612	Peptidase, M16
BME96_10435	COG0612	Peptidase, M16
BME96_10455	COG1744	ABC transporter substrate-binding protein PnrA-like
BME96_10460	COG2188	Transcriptional regulator
BME96_10465	COG1674	ftsk spoiiie
BME96_10475	COG0740	serine-type endopeptidase activity
BME96_10480	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BME96_10485	COG0527	aspartate kinase activity
BME96_10490	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
BME96_10495	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BME96_10500	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BME96_10505	COG1873	PFAM PRC-barrel domain
BME96_10510	COG0612	Peptidase, M16
BME96_10515	COG0726	polysaccharide deacetylase
BME96_10520	COG1185	polyribonucleotide nucleotidyltransferase activity
BME96_10525	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
BME96_10530	COG0196	riboflavin kinase activity
BME96_10535	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
BME96_10540	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
BME96_10550	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
BME96_10555	COG1358	cellular component organization or biogenesis
BME96_10560	COG2740	Nucleic-acid-binding protein implicated in transcription termination
BME96_10565	COG0195	Participates in both transcription termination and antitermination
BME96_10570	COG0779	Required for maturation of 30S ribosomal subunits
BME96_10575	COG1366	Belongs to the anti-sigma-factor antagonist family
BME96_10580	COG2176	DNA-directed DNA polymerase activity
BME96_10585	COG0750	zinc metalloprotease
BME96_10590	COG4589	Belongs to the CDS family
BME96_10595	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
BME96_10600	COG0233	cytoplasmic translational termination
BME96_10605	COG0528	UMP kinase activity
BME96_10610	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
BME96_10615	COG0052	Belongs to the universal ribosomal protein uS2 family
BME96_10630	COG1191	sigma factor activity
BME96_10635	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
BME96_10640	COG1776	CheC inhibitor of MCP methylation
BME96_10645	COG0835	chemotaxis
BME96_10650	COG2201	protein-glutamate methylesterase activity
BME96_10655	COG0455	bacterial-type flagellum organization
BME96_10660	COG1419	protein localization to endoplasmic reticulum
BME96_10665	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BME96_10670	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BME96_10675	COG1684	flagellar biosynthetic protein fliR
BME96_10680	COG1987	bacterial-type flagellum assembly
BME96_10685	COG1338	Plays a role in the flagellum-specific transport system
BME96_10690	COG3190	flagellar
BME96_10695	COG2201	protein-glutamate methylesterase activity
BME96_10700	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
BME96_10700	COG1776	CheC inhibitor of MCP methylation
BME96_10705	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
BME96_10710	COG1580	Controls the rotational direction of flagella during chemotaxis
BME96_10715	COG1582	Flagellar protein (FlbD)
BME96_10720	COG4786	Flagellar basal body rod
BME96_10730	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
BME96_10750	COG1157	protein secretion by the type III secretion system
BME96_10760	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
BME96_10765	COG1766	The M ring may be actively involved in energy transduction
BME96_10770	COG1677	Flagellar hook-basal body complex protein FliE
BME96_10775	COG1558	bacterial-type flagellum-dependent cell motility
BME96_10780	COG1815	bacterial-type flagellum-dependent cell motility
BME96_10785	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
BME96_10790	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
BME96_10795	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
BME96_10800	COG4974	Belongs to the 'phage' integrase family
BME96_10815	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BME96_10820	COG0758	DNA mediated transformation
BME96_10825	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
BME96_10830	COG0045	succinate-CoA ligase (ADP-forming) activity
BME96_10835	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BME96_10845	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
BME96_10850	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
BME96_10860	COG0335	large ribosomal subunit rRNA binding
BME96_10865	COG0336	Belongs to the RNA methyltransferase TrmD family
BME96_10870	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
BME96_10880	COG1837	Belongs to the UPF0109 family
BME96_10885	COG0228	four-way junction DNA binding
BME96_10890	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
BME96_10895	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
BME96_10900	COG0552	protein localization to endoplasmic reticulum
BME96_10905	COG1196	nuclear chromosome segregation
BME96_10910	COG4840	Belongs to the UPF0435 family
BME96_10915	COG0571	ribonuclease III activity
BME96_10920	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BME96_10925	COG1028	Short-chain dehydrogenase reductase Sdr
BME96_10930	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
BME96_10935	COG0416	fatty acid biosynthetic process
BME96_10940	COG1349	DNA-binding transcription factor activity
BME96_10945	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
BME96_10950	COG1760	l-serine dehydratase
BME96_10955	COG1760	l-serine dehydratase
BME96_10965	COG1461	Dihydroxyacetone kinase
BME96_10970	COG1302	Protein conserved in bacteria
BME96_10975	COG0227	Belongs to the bacterial ribosomal protein bL28 family
BME96_10985	COG1564	THIamine pyrophosphokinase
BME96_10990	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
BME96_10995	COG1162	GTPase activity
BME96_11000	COG0515	serine threonine protein kinase
BME96_11000	COG2815	serine threonine protein kinase
BME96_11005	COG0631	protein serine/threonine phosphatase activity
BME96_11010	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BME96_11010	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BME96_11015	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BME96_11020	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BME96_11025	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BME96_11030	COG1758	RNA polymerase activity
BME96_11035	COG0194	GDP metabolic process
BME96_11040	COG2052	Domain of unknown function (DUF370)
BME96_11045	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
BME96_11055	COG1764	response to oxidative stress
BME96_11060	COG0583	DNA-binding transcription factor activity
BME96_11065	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
BME96_11070	COG0284	orotidine-5'-phosphate decarboxylase activity
BME96_11075	COG0167	dihydroorotate dehydrogenase activity
BME96_11080	COG0543	2 iron, 2 sulfur cluster binding
BME96_11085	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BME96_11090	COG0505	Belongs to the CarA family
BME96_11095	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BME96_11100	COG0540	Belongs to the ATCase OTCase family
BME96_11105	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
BME96_11110	COG0564	pseudouridine synthase activity
BME96_11115	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
BME96_11125	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
BME96_11130	COG3599	regulation of cell shape
BME96_11135	COG2302	S4 RNA-binding domain
BME96_11140	COG0762	integral membrane protein
BME96_11145	COG1799	cell septum assembly
BME96_11150	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
BME96_11160	COG1873	PFAM PRC-barrel domain
BME96_11165	COG1191	sigma factor activity
BME96_11170	COG1191	sigma factor activity
BME96_11180	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
BME96_11185	COG0849	cell division
BME96_11190	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
BME96_11195	COG0772	Belongs to the SEDS family
BME96_11200	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
BME96_11205	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BME96_11210	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BME96_11215	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
BME96_11220	COG0768	penicillin binding
BME96_11230	COG4839	cell division protein FtsL
BME96_11235	COG0275	rRNA processing
BME96_11240	COG2001	Belongs to the MraZ family
BME96_11245	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
BME96_11255	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
BME96_11260	COG0454	-acetyltransferase
BME96_11270	COG1024	Enoyl-CoA hydratase
BME96_11275	COG0333	Belongs to the bacterial ribosomal protein bL32 family
BME96_11280	COG1399	metal-binding, possibly nucleic acid-binding protein
BME96_11285	COG1323	Belongs to the UPF0348 family
BME96_11290	COG3480	Lon protease (S16) C-terminal proteolytic domain
BME96_11295	COG3314	Sporulation integral membrane protein YlbJ
BME96_11300	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
BME96_11305	COG0742	ribosomal rna small subunit methyltransferase
BME96_11310	COG4471	UPF0298 protein
BME96_11315	COG3679	Belongs to the UPF0342 family
BME96_11330	COG2340	Cysteine-rich secretory protein family
BME96_11345	COG2322	membrane
BME96_11350	COG3336	cytochrome c oxidase
BME96_11360	COG1845	cytochrome c oxidase, subunit III
BME96_11365	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BME96_11375	COG0109	protoheme IX farnesyltransferase activity
BME96_11380	COG1612	heme a metabolic process
BME96_11385	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
BME96_11390	COG0772	Belongs to the SEDS family
BME96_11395	COG4838	Belongs to the UPF0358 family
BME96_11400	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
BME96_11415	COG4896	Protein conserved in bacteria
BME96_11425	COG0483	inositol monophosphate 1-phosphatase activity
BME96_11435	COG4493	Belongs to the UPF0637 family
BME96_11440	COG4476	Belongs to the UPF0223 family
BME96_11450	COG1982	Orn Lys Arg decarboxylase major
BME96_11475	COG0022	dehydrogenase e1 component
BME96_11485	COG0497	DNA recombination
BME96_11490	COG0242	peptide deformylase activity
BME96_11495	COG0561	phosphatase activity
BME96_11505	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
BME96_11510	COG0028	Belongs to the TPP enzyme family
BME96_11515	COG0569	domain protein
BME96_11520	COG1132	(ABC) transporter
BME96_11525	COG1132	(ABC) transporter
BME96_11530	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BME96_11535	COG0450	alkyl hydroperoxide reductase
BME96_11545	COG1473	amidohydrolase
BME96_11550	COG2171	N-acyltransferase activity
BME96_11555	COG0517	IMP dehydrogenase activity
BME96_11560	COG0640	Transcriptional regulator
BME96_11570	COG1028	Short-chain dehydrogenase reductase Sdr
BME96_11575	COG1408	metallophosphoesterase
BME96_11595	COG0697	spore germination
BME96_11600	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
BME96_11605	COG0436	Aminotransferase
BME96_11615	COG0681	Belongs to the peptidase S26 family
BME96_11625	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BME96_11630	COG3835	regulator
BME96_11645	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BME96_11650	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
BME96_11660	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
BME96_11665	COG0303	'Molybdopterin
BME96_11690	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BME96_11705	COG2323	membrane
BME96_11710	COG1301	dicarboxylic acid transport
BME96_11715	COG0604	alcohol dehydrogenase
BME96_11720	COG0003	Pfam Anion-transporting ATPase
BME96_11730	COG1966	Carbon starvation protein
BME96_11735	COG2427	Protein of unknown function (DUF1641)
BME96_11740	COG3383	formate dehydrogenase (NAD+) activity
BME96_11745	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BME96_11750	COG3069	C4-dicarboxylate transmembrane transporter activity
BME96_11760	COG3859	Proton-coupled thiamine transporter YuaJ
BME96_11765	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
BME96_11785	COG2720	vancomycin resistance protein
BME96_11795	COG1252	NADH dehydrogenase
BME96_11890	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
BME96_11900	COG2027	D-alanyl-D-alanine carboxypeptidase
BME96_11910	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BME96_11915	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BME96_11925	COG4221	oxidoreductase activity
BME96_11930	COG1917	Cupin 2, conserved barrel domain protein
BME96_11935	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
BME96_11950	COG1174	glycine betaine transport
BME96_11955	COG1732	Glycine betaine
BME96_11960	COG1174	glycine betaine transport
BME96_11970	COG1510	regulation of RNA biosynthetic process
BME96_11980	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BME96_11990	COG0402	S-adenosylhomocysteine deaminase activity
BME96_11995	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
BME96_12000	COG0477	Major facilitator Superfamily
BME96_12005	COG1012	belongs to the aldehyde dehydrogenase family
BME96_12010	COG1960	acyl-CoA dehydrogenase activity
BME96_12015	COG1960	acyl-CoA dehydrogenase activity
BME96_12035	COG2030	dehydratase
BME96_12040	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BME96_12040	COG0045	succinate-CoA ligase (ADP-forming) activity
BME96_12040	COG1042	CoA-binding domain protein
BME96_12070	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BME96_12080	COG0495	leucyl-tRNA aminoacylation
BME96_12085	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
BME96_12090	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
BME96_12095	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
BME96_12100	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
BME96_12105	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BME96_12110	COG1116	anion transmembrane transporter activity
BME96_12115	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BME96_12120	COG0494	nUDIX hydrolase
BME96_12135	COG1120	ATPase activity
BME96_12140	COG0318	PFAM AMP-dependent synthetase and ligase
BME96_12145	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
BME96_12150	COG0596	Alpha beta hydrolase
BME96_12155	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
BME96_12160	COG1169	isochorismate synthase
BME96_12165	COG1575	Belongs to the MenA family. Type 1 subfamily
BME96_12170	COG2050	protein possibly involved in aromatic compounds catabolism
BME96_12175	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
BME96_12180	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
BME96_12185	COG1404	Belongs to the peptidase S8 family
BME96_12185	COG4412	M6 family metalloprotease domain protein
BME96_12200	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BME96_12210	COG1098	S1 RNA binding domain
BME96_12215	COG2155	Conserved Protein
BME96_12220	COG0166	Belongs to the GPI family
BME96_12225	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
BME96_12230	COG2032	superoxide dismutase activity
BME96_12245	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BME96_12250	COG0813	purine-nucleoside phosphorylase activity
BME96_12255	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
BME96_12260	COG3584	3D domain protein
BME96_12270	COG1252	NADH dehydrogenase
BME96_12275	COG0492	ferredoxin-NADP+ reductase activity
BME96_12280	COG0316	Belongs to the HesB IscA family
BME96_12285	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
BME96_12290	COG4837	Protein of unknown function (DUF1462)
BME96_12295	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
BME96_12300	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BME96_12305	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
BME96_12310	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
BME96_12315	COG0647	UMP catabolic process
BME96_12325	COG2445	Protein of unknown function DUF86
BME96_12335	COG0154	amidase activity
BME96_12345	COG4470	Protein conserved in bacteria
BME96_12355	COG0739	heme binding
BME96_12360	COG0733	neurotransmitter:sodium symporter activity
BME96_12365	COG1757	Na H antiporter
BME96_12380	COG3377	Domain of unknown function (DUF1805)
BME96_12385	COG0737	Belongs to the 5'-nucleotidase family
BME96_12390	COG0730	response to heat
BME96_12400	COG1674	ftsk spoiiie
BME96_12420	COG1876	peptidase activity
BME96_12585	COG0305	Participates in initiation and elongation during chromosome replication
BME96_12600	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
BME96_12620	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
BME96_12670	COG0719	Fe-S assembly protein
BME96_12675	COG0822	iron-sulfur transferase activity
BME96_12680	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BME96_12685	COG0719	Fe-S assembly protein
BME96_12690	COG0396	ATPase activity
BME96_12695	COG1464	Belongs to the NlpA lipoprotein family
BME96_12700	COG2011	ABC-type metal ion transport system permease component
BME96_12705	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BME96_12710	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BME96_12715	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
BME96_12720	COG0509	glycine decarboxylation via glycine cleavage system
BME96_12725	COG1393	Belongs to the ArsC family
BME96_12730	COG1960	acyl-CoA dehydrogenase activity
BME96_12735	COG0183	Belongs to the thiolase family
BME96_12740	COG1024	Enoyl-CoA hydratase
BME96_12740	COG1250	3-hydroxyacyl-CoA dehydrogenase
BME96_12745	COG0506	proline dehydrogenase activity
BME96_12755	COG2217	Heavy metal translocating P-type atpase
BME96_12760	COG1937	Protein conserved in bacteria
BME96_12765	COG0803	Belongs to the bacterial solute-binding protein 9 family
BME96_12765	COG3443	Belongs to the bacterial solute-binding protein 9 family
BME96_12770	COG1121	(ABC) transporter
BME96_12775	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BME96_12785	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BME96_12800	COG0791	NLP P60 protein
BME96_12800	COG3883	PFAM NLP P60 protein
BME96_12805	COG2224	Isocitrate lyase
BME96_12810	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
BME96_12815	COG4129	membrane
BME96_12820	COG2197	response regulator
BME96_12825	COG4585	Histidine kinase
BME96_12830	COG4758	membrane
BME96_12845	COG2814	Major facilitator Superfamily
BME96_12850	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BME96_12865	COG1363	Peptidase, m42
BME96_12905	COG1388	LysM domain
BME96_12915	COG2217	Heavy metal translocating P-type atpase
BME96_12920	COG1937	Protein conserved in bacteria
BME96_12935	COG5002	protein histidine kinase activity
BME96_12945	COG2217	Heavy metal translocating P-type atpase
BME96_12950	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BME96_12955	COG0785	Cytochrome C biogenesis protein
BME96_12980	COG5002	protein histidine kinase activity
BME96_12985	COG0745	RESPONSE REGULATOR receiver
BME96_12995	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BME96_13065	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BME96_13070	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
BME96_13075	COG0640	Transcriptional regulator
BME96_13080	COG0640	Transcriptional regulator
BME96_13100	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
BME96_13105	COG0803	Belongs to the bacterial solute-binding protein 9 family
BME96_13110	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BME96_13115	COG1121	(ABC) transporter
BME96_13120	COG0557	exoribonuclease II activity
BME96_13125	COG1647	Serine aminopeptidase, S33
BME96_13130	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BME96_13155	COG0148	phosphopyruvate hydratase activity
BME96_13160	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
BME96_13165	COG0149	triose-phosphate isomerase activity
BME96_13170	COG0126	phosphoglycerate kinase activity
BME96_13190	COG0328	RNA-DNA hybrid ribonuclease activity
BME96_13195	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BME96_13200	COG3162	membrane
BME96_13205	COG2610	gluconate transmembrane transporter activity
BME96_13215	COG1028	Short-chain dehydrogenase reductase Sdr
BME96_13220	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
BME96_13225	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
BME96_13240	COG0710	3-dehydroquinate dehydratase activity
BME96_13245	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
BME96_13260	COG0740	serine-type endopeptidase activity
BME96_13265	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BME96_13270	COG1481	regulation of sporulation
BME96_13275	COG0391	Required for morphogenesis under gluconeogenic growth conditions
BME96_13280	COG1660	Displays ATPase and GTPase activities
BME96_13285	COG1051	belongs to the nudix hydrolase family
BME96_13290	COG0492	ferredoxin-NADP+ reductase activity
BME96_13295	COG0457	Tetratricopeptide repeat
BME96_13300	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
BME96_13305	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
BME96_13310	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
BME96_13315	COG0110	maltose O-acetyltransferase activity
BME96_13320	COG0546	phosphoglycolate phosphatase activity
BME96_13325	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
BME96_13330	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
BME96_13335	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
BME96_13340	COG1950	PFAM Membrane protein of
BME96_13345	COG1983	PspC domain protein
BME96_13355	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
BME96_13360	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BME96_13365	COG0556	nucleotide-excision repair
BME96_13375	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BME96_13380	COG0793	Belongs to the peptidase S41A family
BME96_13380	COG3409	Peptidoglycan-binding domain 1 protein
BME96_13385	COG0739	heme binding
BME96_13390	COG2177	Part of the ABC transporter FtsEX involved in
BME96_13395	COG2884	Cell division ATP-binding protein ftsE
BME96_13405	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
BME96_13410	COG0653	protein targeting
BME96_13415	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
BME96_13425	COG1516	flagellar protein fliS
BME96_13430	COG1334	flagellar protein FlaG
BME96_13435	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
BME96_13440	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
BME96_13450	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BME96_13455	COG1256	bacterial-type flagellum assembly
BME96_13455	COG4786	Flagellar basal body rod
BME96_13475	COG1040	competence protein
BME96_13480	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
BME96_13485	COG1307	EDD domain protein, DegV family
BME96_13490	COG2197	response regulator
BME96_13495	COG4585	Histidine kinase
BME96_13500	COG1739	Uncharacterized protein family UPF0029
BME96_13505	COG0363	glucosamine-6-phosphate deaminase activity
BME96_13510	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
BME96_13515	COG1263	PTS System
BME96_13515	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BME96_13515	COG2190	(PTS) system
BME96_13525	COG1396	sequence-specific DNA binding
BME96_13535	COG0681	Belongs to the peptidase S26 family
BME96_13555	COG3764	Sortase (surface protein transpeptidase)
BME96_13560	COG1316	TRANSCRIPTIONal
BME96_13565	COG0768	penicillin binding
BME96_13585	COG1012	belongs to the aldehyde dehydrogenase family
BME96_13595	COG0561	phosphatase activity
BME96_13600	COG2814	Major facilitator Superfamily
BME96_13605	COG1984	allophanate hydrolase subunit 2
BME96_13610	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
BME96_13615	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
BME96_13620	COG0471	metal ion transport
BME96_13625	COG2814	Major facilitator Superfamily
BME96_13630	COG2807	transmembrane transport
BME96_13640	COG1368	sulfuric ester hydrolase activity
BME96_13655	COG0840	transmembrane signaling receptor activity
BME96_13660	COG2200	EAL domain
BME96_13665	COG2201	protein-glutamate methylesterase activity
BME96_13670	COG0835	chemotaxis
BME96_13675	COG0643	Histidine kinase
BME96_13675	COG2198	Histidine kinase
BME96_13685	COG1360	Flagellar Motor Protein
BME96_13690	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
BME96_13695	COG0840	transmembrane signaling receptor activity
BME96_13700	COG1012	belongs to the aldehyde dehydrogenase family
BME96_13705	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
BME96_13740	COG0840	transmembrane signaling receptor activity
BME96_13750	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BME96_13755	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
BME96_13760	COG1472	Belongs to the glycosyl hydrolase 3 family
BME96_13765	COG3876	Protein conserved in bacteria
BME96_13770	COG0395	ABC-type sugar transport system, permease component
BME96_13785	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
BME96_13790	COG1737	Transcriptional regulator
BME96_13795	COG0716	FMN binding
BME96_13810	COG1331	Highly conserved protein containing a thioredoxin domain
BME96_13840	COG1971	Probably functions as a manganese efflux pump
BME96_13855	COG2996	Protein conserved in bacteria
BME96_13865	COG4895	conserved protein (DUF2196)
BME96_13880	COG0561	phosphatase activity
BME96_13900	COG4565	transcriptional regulatory protein
BME96_13905	COG3290	protein histidine kinase activity
BME96_13910	COG2271	Major facilitator Superfamily
BME96_13915	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BME96_13930	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
BME96_13950	COG0601	transmembrane transport
BME96_13955	COG4608	Belongs to the ABC transporter superfamily
BME96_13965	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
BME96_13975	COG0463	Glycosyl transferase, family 2
BME96_13985	COG2076	Multidrug Resistance protein
BME96_13990	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
BME96_14000	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
BME96_14010	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BME96_14020	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BME96_14025	COG0066	3-isopropylmalate dehydratase activity
BME96_14030	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
BME96_14035	COG0473	3-isopropylmalate dehydrogenase activity
BME96_14040	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BME96_14045	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
BME96_14050	COG0440	acetolactate synthase activity
BME96_14055	COG0028	Belongs to the TPP enzyme family
BME96_14060	COG0129	dihydroxy-acid dehydratase activity
BME96_14065	COG0385	Bile acid
BME96_14070	COG1574	metal-dependent hydrolase with the TIM-barrel fold
BME96_14075	COG0473	3-isopropylmalate dehydrogenase activity
BME96_14080	COG1757	Na H antiporter
BME96_14085	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
BME96_14095	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BME96_14100	COG1473	amidohydrolase
BME96_14105	COG0251	oxidation-reduction process
BME96_14110	COG1012	belongs to the aldehyde dehydrogenase family
BME96_14115	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
BME96_14120	COG1802	Transcriptional regulator
BME96_14125	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BME96_14130	COG0006	proline dipeptidase activity
BME96_14135	COG0833	amino acid
BME96_14140	COG0656	L-ascorbic acid biosynthetic process
BME96_14165	COG0805	protein transport
BME96_14170	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
BME96_14180	COG1028	Short-chain dehydrogenase reductase Sdr
BME96_14190	COG0860	N-Acetylmuramoyl-L-alanine amidase
BME96_14200	COG0583	DNA-binding transcription factor activity
BME96_14205	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
BME96_14210	COG0686	Belongs to the AlaDH PNT family
BME96_14220	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BME96_14230	COG0765	amino acid transport
BME96_14235	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BME96_14240	COG1012	belongs to the aldehyde dehydrogenase family
BME96_14245	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
BME96_14250	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BME96_14260	COG3258	Cytochrome c
BME96_14270	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BME96_14290	COG0419	ATPase involved in DNA repair
BME96_14295	COG0420	3'-5' exonuclease activity
BME96_14310	COG0628	permease
BME96_14315	COG1846	Transcriptional regulator
BME96_14320	COG2814	Major facilitator Superfamily
BME96_14325	COG0351	phosphomethylpyrimidine kinase
BME96_14335	COG0390	transport system, permease component
BME96_14350	COG2706	6-phosphogluconolactonase activity
BME96_14360	COG0516	GMP reductase activity
BME96_14370	COG0010	Belongs to the arginase family
BME96_14375	COG0786	glutamate:sodium symporter activity
BME96_14385	COG1105	Belongs to the carbohydrate kinase PfkB family
BME96_14390	COG3684	Belongs to the aldolase LacD family
BME96_14405	COG3716	PTS system mannose fructose sorbose family IID component
BME96_14410	COG3715	PTS system
BME96_14415	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BME96_14420	COG2222	sugar isomerase
BME96_14435	COG1929	Belongs to the glycerate kinase type-1 family
BME96_14445	COG3119	arylsulfatase activity
BME96_14450	COG5426	von Willebrand factor, type A
BME96_14460	COG1175	transmembrane transport
BME96_14465	COG1653	transport
BME96_14470	COG1917	Cupin 2, conserved barrel domain protein
BME96_14470	COG2207	Transcriptional regulator
BME96_14475	COG4166	transmembrane transport
BME96_14485	COG1609	Transcriptional regulator
BME96_14495	COG1316	TRANSCRIPTIONal
BME96_14510	COG4166	transmembrane transport
BME96_14535	COG1562	ergosterol biosynthetic process
BME96_14550	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
BME96_14555	COG0840	transmembrane signaling receptor activity
BME96_14560	COG2233	PERMEase
BME96_14570	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
BME96_14580	COG0006	proline dipeptidase activity
BME96_14595	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
BME96_14600	COG2223	nitrite transmembrane transporter activity
BME96_14610	COG0405	Gamma-glutamyltransferase
BME96_14620	COG3764	Sortase (surface protein transpeptidase)
BME96_14630	COG1268	BioY protein
BME96_14645	COG1757	Na H antiporter
BME96_14650	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
BME96_14655	COG3829	transcription factor binding
BME96_14655	COG3290	protein histidine kinase activity
BME96_14660	COG3383	formate dehydrogenase (NAD+) activity
BME96_14665	COG5609	conserved protein (DUF2294)
BME96_14670	COG3223	Belongs to the PsiE family
BME96_14675	COG1396	sequence-specific DNA binding
BME96_14675	COG1917	Cupin 2, conserved barrel domain protein
BME96_14680	COG5505	Protein of unknown function (DUF819)
BME96_14690	COG0431	NADPH-dependent FMN reductase
BME96_14695	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BME96_14705	COG1012	belongs to the aldehyde dehydrogenase family
BME96_14715	COG1228	amidohydrolase
BME96_14740	COG3541	Predicted nucleotidyltransferase
BME96_14750	COG0706	membrane insertase activity
BME96_14755	COG1404	Belongs to the peptidase S8 family
BME96_14760	COG2814	Major facilitator Superfamily
BME96_14770	COG4948	Mandelate Racemase Muconate Lactonizing
BME96_14775	COG1404	Belongs to the peptidase S8 family
BME96_14780	COG2027	D-alanyl-D-alanine carboxypeptidase
BME96_14785	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BME96_14795	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BME96_14800	COG3291	Pkd domain containing protein
BME96_14800	COG3525	Glycosyl hydrolase, family 20, catalytic domain
BME96_14805	COG1556	Lactate utilization protein
BME96_14810	COG1139	Iron-sulfur cluster binding protein
BME96_14815	COG0247	lactate metabolic process
BME96_14820	COG2186	Transcriptional regulator
BME96_14835	COG1737	Transcriptional regulator
BME96_14840	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
BME96_14850	COG2190	(PTS) system
BME96_14860	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BME96_14865	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
BME96_14875	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
BME96_14885	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BME96_14965	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BME96_14975	COG1028	Short-chain dehydrogenase reductase Sdr
BME96_14980	COG1215	transferase activity, transferring glycosyl groups
BME96_15000	COG2197	response regulator
BME96_15020	COG2368	4-hydroxyphenylacetate
BME96_15025	COG1132	(ABC) transporter
BME96_15035	COG1012	belongs to the aldehyde dehydrogenase family
BME96_15040	COG0840	transmembrane signaling receptor activity
BME96_15050	COG1609	Transcriptional regulator
BME96_15065	COG2233	PERMEase
BME96_15070	COG0402	S-adenosylhomocysteine deaminase activity
BME96_15080	COG3775	system Galactitol-specific IIC component
BME96_15090	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
BME96_15095	COG2022	thiamine diphosphate biosynthetic process
BME96_15100	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BME96_15105	COG0352	thiamine-phosphate diphosphorylase activity
BME96_15115	COG0549	Belongs to the carbamate kinase family
BME96_15120	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
BME96_15135	COG1737	Transcriptional regulator
BME96_15140	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
BME96_15145	COG3876	Protein conserved in bacteria
BME96_15150	COG1472	Belongs to the glycosyl hydrolase 3 family
BME96_15155	COG0395	ABC-type sugar transport system, permease component
BME96_15160	COG1175	transmembrane transport
BME96_15180	COG0438	transferase activity, transferring glycosyl groups
BME96_15190	COG0515	serine threonine protein kinase
BME96_15220	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BME96_15240	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
BME96_15245	COG1082	Xylose isomerase domain protein TIM barrel
BME96_15250	COG0673	inositol 2-dehydrogenase activity
BME96_15255	COG0673	inositol 2-dehydrogenase activity
BME96_15265	COG0673	inositol 2-dehydrogenase activity
BME96_15280	COG1653	transport
BME96_15285	COG1028	Short-chain dehydrogenase reductase Sdr
BME96_15290	COG1609	Transcriptional regulator
BME96_15295	COG1473	amidohydrolase
BME96_15305	COG1288	antiporter activity
BME96_15310	COG4948	Mandelate Racemase Muconate Lactonizing
BME96_15335	COG1454	alcohol dehydrogenase
BME96_15345	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BME96_15360	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BME96_15375	COG2514	catechol 2,3-dioxygenase activity
BME96_15380	COG1733	regulation of RNA biosynthetic process
BME96_15385	COG3119	arylsulfatase activity
BME96_15400	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BME96_15415	COG1262	PFAM Formylglycine-generating sulfatase enzyme
BME96_15420	COG0583	DNA-binding transcription factor activity
BME96_15445	COG2056	Na+-H+ antiporter family
BME96_15450	COG2986	histidine ammonia-lyase
BME96_15460	COG2195	Cleaves the N-terminal amino acid of tripeptides
BME96_15465	COG1228	amidohydrolase
BME96_15470	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
BME96_15475	COG0583	DNA-binding transcription factor activity
BME96_15485	COG1846	Transcriptional regulator
BME96_15490	COG1033	growth of symbiont in host cell
BME96_15490	COG2409	Drug exporters of the RND superfamily
BME96_15505	COG4166	transmembrane transport
BME96_15525	COG1595	DNA-templated transcription, initiation
BME96_15545	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BME96_15550	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BME96_15555	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BME96_15565	COG0681	Belongs to the peptidase S26 family
BME96_15600	COG0366	Alpha amylase catalytic
BME96_15605	COG3345	alpha-galactosidase
BME96_15615	COG0561	phosphatase activity
BME96_15625	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BME96_15625	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BME96_15625	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BME96_15630	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BME96_15630	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BME96_15630	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BME96_15635	COG1105	Belongs to the carbohydrate kinase PfkB family
BME96_15645	COG1012	belongs to the aldehyde dehydrogenase family
BME96_15650	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BME96_15655	COG1757	Na H antiporter
BME96_15665	COG3938	Belongs to the proline racemase family
BME96_15670	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BME96_15695	COG2362	D-Aminopeptidase
BME96_15705	COG0366	Alpha amylase catalytic
BME96_15715	COG1609	Transcriptional regulator
BME96_15745	COG1011	Hydrolase
BME96_15750	COG2936	dipeptidyl-peptidase activity
BME96_15755	COG0174	glutamine synthetase
BME96_15760	COG0493	'glutamate synthase
BME96_15765	COG0067	glutamate synthase
BME96_15765	COG0070	glutamate synthase
BME96_15765	COG0069	glutamate synthase activity
BME96_15770	COG0583	DNA-binding transcription factor activity
BME96_15775	COG0367	asparagine synthase
BME96_15780	COG0446	pyridine nucleotide-disulphide oxidoreductase
BME96_15795	COG5444	nuclease activity
BME96_15820	COG5298	Protein conserved in bacteria
BME96_15825	COG1215	transferase activity, transferring glycosyl groups
BME96_15865	COG1757	Na H antiporter
BME96_15870	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BME96_15880	COG1192	Involved in chromosome partitioning
BME96_15900	COG3949	Membrane
BME96_15905	COG4948	Mandelate Racemase Muconate Lactonizing
BME96_15915	COG1473	amidohydrolase
BME96_15925	COG1476	TRANSCRIPTIONal
BME96_15930	COG1960	acyl-CoA dehydrogenase activity
BME96_15935	COG0318	PFAM AMP-dependent synthetase and ligase
BME96_15940	COG0789	Transcriptional regulator
BME96_15985	COG4166	transmembrane transport
BME96_16005	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BME96_16015	COG1396	sequence-specific DNA binding
BME96_16030	COG1522	sequence-specific DNA binding
BME96_16035	COG3949	Membrane
BME96_16040	COG0010	Belongs to the arginase family
BME96_16080	COG1442	glycosyl transferase family 8
BME96_16080	COG1216	Glycosyl transferase, family 2
BME96_16085	COG0438	transferase activity, transferring glycosyl groups
BME96_16090	COG0438	transferase activity, transferring glycosyl groups
BME96_16100	COG0438	transferase activity, transferring glycosyl groups
BME96_16115	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
BME96_16120	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
BME96_16125	COG1210	Utp--glucose-1-phosphate uridylyltransferase
BME96_16135	COG2197	response regulator
BME96_16145	COG4464	protein tyrosine phosphatase activity
BME96_16150	COG0489	protein tyrosine kinase activity
BME96_16155	COG3944	biosynthesis protein
BME96_16160	COG0791	NLP P60 protein
BME96_16160	COG1388	LysM domain
BME96_16175	COG1063	alcohol dehydrogenase
BME96_16205	COG0165	Argininosuccinate lyase
BME96_16215	COG3842	ATPase activity
BME96_16220	COG1840	ABC-type Fe3 transport system, periplasmic component
BME96_16240	COG1940	carbohydrate kinase activity
BME96_16250	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BME96_16255	COG1482	cell wall glycoprotein biosynthetic process
BME96_16260	COG1940	carbohydrate kinase activity
BME96_16270	COG1175	transmembrane transport
BME96_16280	COG2207	Transcriptional regulator
BME96_16280	COG4753	response regulator
BME96_16285	COG2972	Histidine kinase
BME96_16290	COG1879	ABC-type sugar transport system periplasmic component
BME96_16305	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
BME96_16320	COG3142	Participates in the control of copper homeostasis
BME96_16335	COG3711	transcriptional antiterminator
BME96_16345	COG0432	Pfam Uncharacterised protein family UPF0047
BME96_16350	COG0745	RESPONSE REGULATOR receiver
BME96_16350	COG2972	Histidine kinase
BME96_16390	COG1316	TRANSCRIPTIONal
BME96_16395	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BME96_16400	COG0438	transferase activity, transferring glycosyl groups
BME96_16410	COG1216	Glycosyl transferase, family 2
BME96_16430	COG0584	glycerophosphoryl diester phosphodiesterase
BME96_16440	COG1134	teichoic acid transport
BME96_16445	COG1682	transport, permease protein
BME96_16450	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
BME96_16460	COG1210	Utp--glucose-1-phosphate uridylyltransferase
BME96_16465	COG0438	transferase activity, transferring glycosyl groups
BME96_16470	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
BME96_16480	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
BME96_16485	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
BME96_16490	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
BME96_16495	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
BME96_16500	COG1368	sulfuric ester hydrolase activity
BME96_16520	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
BME96_16525	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BME96_16535	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BME96_16545	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BME96_16570	COG2076	Multidrug Resistance protein
BME96_16575	COG2076	Multidrug Resistance protein
BME96_16585	COG1447	Phosphotransferase system cellobiose-specific component IIA
BME96_16595	COG1486	melibiose metabolic process
BME96_16605	COG3394	polysaccharide catabolic process
BME96_16625	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
BME96_16630	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BME96_16640	COG1309	transcriptional regulator
BME96_16650	COG4980	gas vesicle protein
BME96_16660	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BME96_16670	COG4786	Flagellar basal body rod
BME96_16675	COG4786	Flagellar basal body rod
BME96_16680	COG1077	Cell shape determining protein MreB Mrl
BME96_16690	COG1609	Transcriptional regulator
BME96_16700	COG0739	heme binding
BME96_16705	COG2385	sporulation resulting in formation of a cellular spore
BME96_16710	COG4608	Belongs to the ABC transporter superfamily
BME96_16715	COG0791	NLP P60 protein
BME96_16720	COG4948	Mandelate Racemase Muconate Lactonizing
BME96_16725	COG1619	proteins homologs of microcin C7 resistance protein MccF
BME96_16730	COG4166	transmembrane transport
BME96_16735	COG0444	Belongs to the ABC transporter superfamily
BME96_16740	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BME96_16745	COG0601	transmembrane transport
BME96_16750	COG2362	D-Aminopeptidase
BME96_16755	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BME96_16770	COG0355	proton-transporting ATP synthase activity, rotational mechanism
BME96_16775	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
BME96_16780	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
BME96_16785	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
BME96_16790	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BME96_16795	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
BME96_16800	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BME96_16805	COG0356	it plays a direct role in the translocation of protons across the membrane
BME96_16815	COG1404	Belongs to the peptidase S8 family
BME96_16820	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
BME96_16825	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
BME96_16830	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
BME96_16835	COG4475	Protein of unknown function (DUF436)
BME96_16840	COG0698	ribose 5-phosphate isomerase
BME96_16850	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BME96_16855	COG1971	Probably functions as a manganese efflux pump
BME96_16870	COG0009	L-threonylcarbamoyladenylate synthase
BME96_16885	COG2890	protein-(glutamine-N5) methyltransferase activity
BME96_16890	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
BME96_16895	COG1435	thymidine kinase activity
BME96_16900	COG0254	rRNA binding
BME96_16905	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
BME96_16910	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BME96_16915	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
BME96_16920	COG0191	fructose-bisphosphate aldolase activity
BME96_16925	COG2204	response regulator
BME96_16930	COG0504	CTP synthase activity
BME96_16935	COG3343	RNA polymerase activity
BME96_16945	COG1703	isobutyryl-CoA mutase activity
BME96_16945	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
BME96_16945	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
BME96_16955	COG1703	isobutyryl-CoA mutase activity
BME96_16960	COG1960	acyl-CoA dehydrogenase activity
BME96_16965	COG1960	acyl-CoA dehydrogenase activity
BME96_16970	COG1250	3-hydroxyacyl-CoA dehydrogenase
BME96_16975	COG0183	Belongs to the thiolase family
BME96_16980	COG0247	lactate metabolic process
BME96_16980	COG2181	nitrate reductase activity
BME96_16985	COG0018	arginyl-trna synthetase
BME96_16995	COG0010	Belongs to the arginase family
BME96_17005	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BME96_17015	COG3465	dGTPase activity
BME96_17020	COG1078	dGTPase activity
BME96_17025	COG0095	Lipoate-protein ligase
BME96_17030	COG0280	phosphate acetyltransferase
BME96_17050	COG2363	Small membrane protein
BME96_17065	COG0069	glutamate synthase activity
BME96_17090	COG3594	Acyltransferase
BME96_17100	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
BME96_17105	COG1793	dna ligase
BME96_17105	COG3285	dna ligase
BME96_17115	COG1764	response to oxidative stress
BME96_17125	COG3189	MarR family transcriptional regulator
BME96_17130	COG0861	Integral membrane protein TerC family
BME96_17135	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BME96_17140	COG0628	permease
BME96_17160	COG1114	Component of the transport system for branched-chain amino acids
BME96_17165	COG0514	ATP-dependent DNA helicase (RecQ)
BME96_17175	COG1115	amino acid carrier protein
BME96_17180	COG1607	acyl-coa hydrolase
BME96_17185	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BME96_17190	COG0626	cystathionine gamma-synthase activity
BME96_17195	COG2962	Rard protein
BME96_17205	COG2755	lipolytic protein G-D-S-L family
BME96_17210	COG4698	Protein conserved in bacteria
BME96_17230	COG0488	(ABC) transporter
BME96_17235	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BME96_17240	COG0156	8-amino-7-oxononanoate synthase activity
BME96_17245	COG3584	3D domain protein
BME96_17245	COG1388	LysM domain
BME96_17245	COG1388	LysM domain
BME96_17245	COG3584	3D domain protein
BME96_17250	COG4086	secreted protein
BME96_17255	COG2814	Major facilitator Superfamily
BME96_17265	COG1979	alcohol dehydrogenase
BME96_17270	COG0251	oxidation-reduction process
BME96_17275	COG0741	lytic transglycosylase activity
BME96_17285	COG0534	Mate efflux family protein
BME96_17305	COG0318	PFAM AMP-dependent synthetase and ligase
BME96_17310	COG4608	Belongs to the ABC transporter superfamily
BME96_17315	COG0444	Belongs to the ABC transporter superfamily
BME96_17320	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BME96_17325	COG0601	transmembrane transport
BME96_17330	COG4166	transmembrane transport
BME96_17340	COG2070	2-Nitropropane dioxygenase
BME96_17345	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BME96_17350	COG2814	Major facilitator Superfamily
BME96_17355	COG1737	Transcriptional regulator
BME96_17360	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
BME96_17365	COG2610	gluconate transmembrane transporter activity
BME96_17370	COG1070	Carbohydrate kinase
BME96_17380	COG1288	antiporter activity
BME96_17385	COG2032	superoxide dismutase activity
BME96_17395	COG1725	Transcriptional regulator
BME96_17400	COG4152	abc transporter atp-binding protein
BME96_17415	COG0655	NAD(P)H dehydrogenase (quinone) activity
BME96_17420	COG4991	sh3 domain protein
BME96_17420	COG0860	N-Acetylmuramoyl-L-alanine amidase
BME96_17420	COG3103	Sh3 type 3 domain protein
BME96_17430	COG2226	methyltransferase
BME96_17450	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BME96_17465	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BME96_17475	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BME96_17480	COG0583	DNA-binding transcription factor activity
BME96_17485	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BME96_17490	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BME96_17515	COG3246	L-lysine catabolic process to acetate
BME96_17520	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BME96_17525	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BME96_17530	COG2323	membrane
BME96_17535	COG0367	asparagine synthase
BME96_17545	COG1595	DNA-templated transcription, initiation
BME96_17550	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
BME96_17565	COG1115	amino acid carrier protein
BME96_17575	COG2199	diguanylate cyclase activity
BME96_17585	COG0820	rRNA (adenine-C2-)-methyltransferase activity
BME96_17590	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BME96_17595	COG0655	NAD(P)H dehydrogenase (quinone) activity
BME96_17600	COG0501	Belongs to the peptidase M48B family
BME96_17610	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BME96_17615	COG2197	response regulator
BME96_17620	COG4585	Histidine kinase
BME96_17625	COG3239	Fatty acid desaturase
BME96_17640	COG1199	ATP-dependent helicase activity
BME96_17645	COG0427	acetyl-CoA hydrolase
BME96_17650	COG3279	Response regulator of the LytR AlgR family
BME96_17660	COG1252	NADH dehydrogenase
BME96_17665	COG2801	Transposase and inactivated derivatives
BME96_17675	COG1346	cytolysis
BME96_17680	COG1380	Effector of murein hydrolase LrgA
BME96_17685	COG0165	Argininosuccinate lyase
BME96_17690	COG0137	argininosuccinate synthase activity
BME96_17695	COG2076	Multidrug Resistance protein
BME96_17700	COG2076	Multidrug Resistance protein
BME96_17705	COG1309	transcriptional regulator
BME96_17710	COG1028	Short-chain dehydrogenase reductase Sdr
BME96_17725	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
BME96_17730	COG0573	inorganic phosphate transmembrane transporter activity
BME96_17735	COG0581	inorganic phosphate transmembrane transporter activity
BME96_17740	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BME96_17760	COG2323	membrane
BME96_17775	COG2814	Major facilitator Superfamily
BME96_17780	COG2404	hydrolase activity, acting on ester bonds
BME96_17795	COG1595	DNA-templated transcription, initiation
BME96_17815	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BME96_17830	COG1621	beta-fructofuranosidase activity
BME96_17835	COG2190	(PTS) system
BME96_17840	COG3871	stress protein (general stress protein 26)
BME96_17845	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BME96_17855	COG3069	C4-dicarboxylate transmembrane transporter activity
BME96_17870	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
BME96_17880	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
BME96_17905	COG1607	acyl-coa hydrolase
BME96_17925	COG0583	DNA-binding transcription factor activity
BME96_17930	COG1910	domain protein
BME96_17935	COG0725	ABC transporter, periplasmic molybdate-binding protein
BME96_17940	COG4149	molybdate abc transporter
BME96_17945	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
BME96_17955	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BME96_17965	COG3711	transcriptional antiterminator
BME96_17970	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BME96_17970	COG1263	PTS System
BME96_17970	COG2190	(PTS) system
BME96_17980	COG1393	Belongs to the ArsC family
BME96_18000	COG1999	signal sequence binding
BME96_18005	COG1349	DNA-binding transcription factor activity
BME96_18015	COG0785	Cytochrome C biogenesis protein
BME96_18020	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BME96_18025	COG0745	RESPONSE REGULATOR receiver
BME96_18030	COG2205	protein histidine kinase activity
BME96_18035	COG3291	Pkd domain containing protein
BME96_18035	COG4412	M6 family metalloprotease domain protein
BME96_18040	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BME96_18045	COG0730	response to heat
BME96_18050	COG0425	Belongs to the sulfur carrier protein TusA family
BME96_18055	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BME96_18055	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BME96_18060	COG2210	Belongs to the sulfur carrier protein TusA family
BME96_18065	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BME96_18065	COG0425	Belongs to the sulfur carrier protein TusA family
BME96_18070	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BME96_18075	COG2210	Belongs to the sulfur carrier protein TusA family
BME96_18080	COG1937	Protein conserved in bacteria
BME96_18090	COG4536	flavin adenine dinucleotide binding
BME96_18105	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
BME96_18115	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BME96_18115	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BME96_18120	COG0456	acetyltransferase
BME96_18135	COG2719	SpoVR family
BME96_18145	COG2718	Belongs to the UPF0229 family
BME96_18150	COG2766	serine protein kinase
BME96_18155	COG3639	organic phosphonate transmembrane transporter activity
BME96_18160	COG3639	organic phosphonate transmembrane transporter activity
BME96_18165	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
BME96_18175	COG0613	PHP domain protein
BME96_18180	COG4778	phosphonate C-P lyase system protein PhnL
BME96_18185	COG3454	Phosphonate metabolism
BME96_18190	COG4107	phosphonate C-P lyase system protein PhnK
BME96_18195	COG3627	carbon phosphorus lyase activity
BME96_18220	COG2188	Transcriptional regulator
BME96_18230	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
BME96_18260	COG1120	ATPase activity
BME96_18265	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BME96_18270	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BME96_18275	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BME96_18300	COG1301	dicarboxylic acid transport
BME96_18305	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BME96_18310	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
BME96_18325	COG2814	Major facilitator Superfamily
BME96_18330	COG0516	GMP reductase activity
BME96_18330	COG0517	IMP dehydrogenase activity
BME96_18335	COG1846	Transcriptional regulator
BME96_18345	COG1349	DNA-binding transcription factor activity
BME96_18350	COG1105	Belongs to the carbohydrate kinase PfkB family
BME96_18355	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BME96_18355	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BME96_18355	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BME96_18365	COG1827	regulation of RNA biosynthetic process
BME96_18370	COG0157	Belongs to the NadC ModD family
BME96_18390	COG1366	Belongs to the anti-sigma-factor antagonist family
BME96_18400	COG1028	Short-chain dehydrogenase reductase Sdr
BME96_18410	COG0427	acetyl-CoA hydrolase
BME96_18415	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
BME96_18420	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BME96_18445	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
BME96_18485	COG4943	cyclic-guanylate-specific phosphodiesterase activity
BME96_18495	COG0666	response to abiotic stimulus
BME96_18500	COG0402	S-adenosylhomocysteine deaminase activity
BME96_18505	COG0702	epimerase
BME96_18515	COG2217	Heavy metal translocating P-type atpase
BME96_18520	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BME96_18525	COG1028	Short-chain dehydrogenase reductase Sdr
BME96_18530	COG1510	regulation of RNA biosynthetic process
BME96_18555	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BME96_18560	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BME96_18560	COG3711	transcriptional antiterminator
BME96_18565	COG1486	melibiose metabolic process
BME96_18575	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BME96_18580	COG3394	polysaccharide catabolic process
BME96_18585	COG1447	Phosphotransferase system cellobiose-specific component IIA
BME96_18590	COG3876	Protein conserved in bacteria
BME96_18605	COG3773	Cell wall hydrolase
BME96_18620	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
BME96_18625	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
BME96_18695	COG1028	Short-chain dehydrogenase reductase Sdr
BME96_18705	COG1132	(ABC) transporter
BME96_18715	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BME96_18720	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
BME96_18725	COG4853	Protein conserved in bacteria
BME96_18730	COG4863	YycH protein
BME96_18735	COG5002	protein histidine kinase activity
BME96_18740	COG0745	RESPONSE REGULATOR receiver
BME96_18745	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
BME96_18750	COG0305	Participates in initiation and elongation during chromosome replication
BME96_18755	COG0359	binds to the 23S rRNA
BME96_18760	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
BME96_18765	COG4241	membrane
BME96_18775	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
BME96_18780	COG0629	single-stranded DNA binding
BME96_18785	COG0360	Binds together with S18 to 16S ribosomal RNA
BME96_18790	COG0012	GTP binding
BME96_18795	COG4481	Protein conserved in bacteria
BME96_18800	COG0668	transmembrane transport
BME96_18805	COG3949	Membrane
BME96_18820	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BME96_18825	COG1475	DNA binding
BME96_18830	COG1192	Involved in chromosome partitioning
BME96_18835	COG1475	DNA binding
BME96_18840	COG0357	Ribosomal RNA small subunit methyltransferase G
BME96_18845	COG0445	tRNA wobble uridine modification
BME96_18850	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
BME96_18855	COG2234	aminopeptidase activity
BME96_18860	COG1847	R3H domain protein
BME96_18865	COG0706	membrane insertase activity
BME96_18870	COG0594	ribonuclease P activity
BME96_18875	COG0230	Belongs to the bacterial ribosomal protein bL34 family
BME96_18940	COG0551	DNA topoisomerase type I activity
BME96_18940	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BME96_18960	COG1192	Involved in chromosome partitioning
BME96_18965	COG1192	Involved in chromosome partitioning
BME96_19035	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs