locus-tag	class	description
OLD84_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
OLD84_00010	COG0592	DNA-directed DNA polymerase activity
OLD84_00015	COG2501	S4 domain
OLD84_00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
OLD84_00030	COG0187	DNA topoisomerase II activity
OLD84_00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
OLD84_00040	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
OLD84_00055	COG0516	GMP reductase activity
OLD84_00055	COG0517	IMP dehydrogenase activity
OLD84_00065	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
OLD84_00070	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
OLD84_00075	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
OLD84_00090	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
OLD84_00095	COG2011	ABC-type metal ion transport system permease component
OLD84_00100	COG1464	Belongs to the NlpA lipoprotein family
OLD84_00110	COG0768	penicillin binding
OLD84_00120	COG0523	cobalamin synthesis protein
OLD84_00125	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
OLD84_00130	COG0523	cobalamin synthesis protein
OLD84_00135	COG3443	Belongs to the bacterial solute-binding protein 9 family
OLD84_00150	COG2357	RelA SpoT domain protein
OLD84_00155	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
OLD84_00170	COG1428	Deoxynucleoside kinase
OLD84_00175	COG1428	Deoxynucleoside kinase
OLD84_00185	COG0582	viral genome integration into host DNA
OLD84_00210	COG3561	AntA/AntB antirepressor
OLD84_00300	COG0305	Participates in initiation and elongation during chromosome replication
OLD84_00310	COG0629	single-stranded DNA binding
OLD84_00320	COG0863	Belongs to the N(4) N(6)-methyltransferase family
OLD84_00570	COG1301	dicarboxylic acid transport
OLD84_00575	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
OLD84_00585	COG1017	nitric oxide dioxygenase activity
OLD84_00585	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
OLD84_00590	COG1959	2 iron, 2 sulfur cluster binding
OLD84_00595	COG0693	protein deglycase activity
OLD84_00600	COG1388	LysM domain
OLD84_00600	COG3858	chitin binding
OLD84_00605	COG1335	isochorismatase
OLD84_00610	COG0590	tRNA wobble adenosine to inosine editing
OLD84_00635	COG3457	Alanine racemase
OLD84_00645	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
OLD84_00650	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
OLD84_00655	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
OLD84_00695	COG5632	N-Acetylmuramoyl-L-alanine amidase
OLD84_00695	COG3409	Peptidoglycan-binding domain 1 protein
OLD84_00720	COG4824	toxin secretion phage lysis holin
OLD84_00760	COG5632	N-Acetylmuramoyl-L-alanine amidase
OLD84_00760	COG3409	Peptidoglycan-binding domain 1 protein
OLD84_00790	COG1547	Domain of unknown function (DUF309)
OLD84_00795	COG3142	Participates in the control of copper homeostasis
OLD84_00800	COG2223	nitrite transmembrane transporter activity
OLD84_00815	COG0733	neurotransmitter:sodium symporter activity
OLD84_00835	COG1982	Orn Lys Arg decarboxylase major
OLD84_00840	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
OLD84_00845	COG3870	Protein conserved in bacteria
OLD84_00850	COG1728	Protein conserved in bacteria
OLD84_00855	COG0470	DNA polymerase III
OLD84_00860	COG1774	PSP1 C-terminal conserved region
OLD84_00865	COG4467	Involved in initiation control of chromosome replication
OLD84_00870	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
OLD84_00875	COG2827	Endonuclease containing a URI domain
OLD84_00880	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
OLD84_00885	COG2002	toxin-antitoxin pair type II binding
OLD84_00895	COG0084	hydrolase, TatD family'
OLD84_00900	COG3584	3D domain protein
OLD84_00900	COG3583	domain protein
OLD84_00910	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
OLD84_00915	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
OLD84_00925	COG4466	Protein conserved in bacteria
OLD84_00935	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
OLD84_00940	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
OLD84_00950	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
OLD84_00955	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
OLD84_00960	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
OLD84_00965	COG0193	aminoacyl-tRNA hydrolase activity
OLD84_00975	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
OLD84_00980	COG2002	toxin-antitoxin pair type II binding
OLD84_00990	COG3177	Filamentation induced by cAMP protein fic
OLD84_01005	COG1595	DNA-templated transcription, initiation
OLD84_01020	COG2337	Toxic component of a toxin-antitoxin (TA) module
OLD84_01025	COG2244	polysaccharide biosynthetic process
OLD84_01030	COG3956	TIGRFAM MazG family protein
OLD84_01035	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
OLD84_01055	COG1098	S1 RNA binding domain
OLD84_01070	COG2814	Major facilitator Superfamily
OLD84_01080	COG2208	phosphoserine phosphatase activity
OLD84_01085	COG2304	oxidoreductase activity
OLD84_01090	COG0515	serine threonine protein kinase
OLD84_01095	COG0037	tRNA processing
OLD84_01100	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
OLD84_01105	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
OLD84_01110	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
OLD84_01115	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
OLD84_01120	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
OLD84_01125	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
OLD84_01130	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
OLD84_01135	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
OLD84_01140	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
OLD84_01145	COG1396	sequence-specific DNA binding
OLD84_01155	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
OLD84_01235	COG1285	pathogenesis
OLD84_01245	COG3880	PFAM UvrB UvrC protein
OLD84_01250	COG3869	Catalyzes the specific phosphorylation of arginine residues in
OLD84_01255	COG0542	response to heat
OLD84_01260	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
OLD84_01265	COG4956	integral membrane protein (PIN domain superfamily)
OLD84_01270	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
OLD84_01275	COG1045	serine acetyltransferase
OLD84_01280	COG0215	cysteine-tRNA ligase activity
OLD84_01290	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
OLD84_01295	COG3688	RNA-binding protein containing a PIN domain
OLD84_01305	COG0267	Belongs to the bacterial ribosomal protein bL33 family
OLD84_01310	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
OLD84_01315	COG0250	Participates in transcription elongation, termination and antitermination
OLD84_01320	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
OLD84_01325	COG0081	regulation of translation
OLD84_01330	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
OLD84_01335	COG0222	ribosome binding
OLD84_01340	COG2813	Specifically methylates the guanine in position
OLD84_01345	COG0085	RNA polymerase activity
OLD84_01350	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
OLD84_01355	COG1358	cellular component organization or biogenesis
OLD84_01360	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
OLD84_01365	COG0049	tRNA binding
OLD84_01370	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
OLD84_01375	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
OLD84_01380	COG0051	transcription antitermination factor activity, RNA binding
OLD84_01385	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
OLD84_01390	COG0088	Forms part of the polypeptide exit tunnel
OLD84_01395	COG0089	rRNA binding
OLD84_01400	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
OLD84_01405	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
OLD84_01410	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
OLD84_01415	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
OLD84_01420	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
OLD84_01425	COG0255	Belongs to the universal ribosomal protein uL29 family
OLD84_01430	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
OLD84_01435	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
OLD84_01440	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
OLD84_01445	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
OLD84_01450	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
OLD84_01455	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
OLD84_01460	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
OLD84_01465	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
OLD84_01470	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
OLD84_01475	COG1841	ribosomal large subunit assembly
OLD84_01480	COG0200	Binds to the 23S rRNA
OLD84_01485	COG0201	protein transport
OLD84_01490	COG0563	adenylate kinase activity
OLD84_01495	COG2163	COG2163 Ribosomal protein L14E L6E L27E
OLD84_01500	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
OLD84_01505	COG0257	Belongs to the bacterial ribosomal protein bL36 family
OLD84_01510	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
OLD84_01515	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
OLD84_01520	COG0202	RNA polymerase activity
OLD84_01525	COG0203	ribosomal protein L17
OLD84_01530	COG1122	ATPase activity
OLD84_01535	COG1122	ATPase activity
OLD84_01540	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
OLD84_01545	COG0101	tRNA pseudouridine synthase activity
OLD84_01550	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
OLD84_01555	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
OLD84_01575	COG1295	ribonuclease BN
OLD84_01635	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
OLD84_01725	COG0860	N-Acetylmuramoyl-L-alanine amidase
OLD84_01730	COG0489	protein tyrosine kinase activity
OLD84_01740	COG2194	sulfuric ester hydrolase activity
OLD84_01745	COG0726	polysaccharide deacetylase
OLD84_01785	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
OLD84_01855	COG2189	Belongs to the N(4) N(6)-methyltransferase family
OLD84_01860	COG3421	Type III restriction
OLD84_01935	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
OLD84_01960	COG1595	DNA-templated transcription, initiation
OLD84_01965	COG5662	AntiSigma factor
OLD84_01970	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
OLD84_01975	COG4856	YbbR-like protein
OLD84_01980	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
OLD84_01985	COG0745	RESPONSE REGULATOR receiver
OLD84_01990	COG3850	Histidine kinase
OLD84_01990	COG5002	protein histidine kinase activity
OLD84_01995	COG0577	efflux transmembrane transporter activity
OLD84_02000	COG1136	(ABC) transporter
OLD84_02020	COG0640	Transcriptional regulator
OLD84_02050	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
OLD84_02055	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
OLD84_02060	COG1120	ATPase activity
OLD84_02065	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
OLD84_02080	COG1492	cobalamin metabolic process
OLD84_02085	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
OLD84_02090	COG0406	alpha-ribazole phosphatase activity
OLD84_02100	COG2096	Adenosyltransferase
OLD84_02115	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
OLD84_02120	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
OLD84_02155	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
OLD84_02160	COG2323	membrane
OLD84_02170	COG1309	transcriptional regulator
OLD84_02180	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
OLD84_02195	COG1733	regulation of RNA biosynthetic process
OLD84_02200	COG1522	sequence-specific DNA binding
OLD84_02205	COG1335	isochorismatase
OLD84_02210	COG0730	response to heat
OLD84_02215	COG0583	DNA-binding transcription factor activity
OLD84_02225	COG0431	NADPH-dependent FMN reductase
OLD84_02230	COG2814	Major facilitator Superfamily
OLD84_02235	COG2258	MOSC domain
OLD84_02240	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
OLD84_02245	COG1131	(ABC) transporter
OLD84_02255	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
OLD84_02260	COG0659	secondary active sulfate transmembrane transporter activity
OLD84_02270	COG1937	Protein conserved in bacteria
OLD84_02275	COG2217	Heavy metal translocating P-type atpase
OLD84_02310	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
OLD84_02315	COG1140	nitrate reductase beta subunit
OLD84_02325	COG2181	nitrate reductase activity
OLD84_02360	COG2223	nitrite transmembrane transporter activity
OLD84_02385	COG0716	FMN binding
OLD84_02390	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
OLD84_02395	COG3383	formate dehydrogenase (NAD+) activity
OLD84_02405	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
OLD84_02410	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
OLD84_02415	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
OLD84_02420	COG0303	'Molybdopterin
OLD84_02425	COG0314	molybdopterin synthase activity
OLD84_02430	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
OLD84_02435	COG1763	Mo-molybdopterin cofactor biosynthetic process
OLD84_02440	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
OLD84_02445	COG0746	molybdenum cofactor guanylyltransferase activity
OLD84_02450	COG0521	Mo-molybdopterin cofactor biosynthetic process
OLD84_02455	COG0725	ABC transporter, periplasmic molybdate-binding protein
OLD84_02460	COG4149	molybdate abc transporter
OLD84_02465	COG1619	proteins homologs of microcin C7 resistance protein MccF
OLD84_02475	COG3385	transposase activity
OLD84_02480	COG0315	cyclic pyranopterin monophosphate synthase activity
OLD84_02485	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
OLD84_02490	COG2304	oxidoreductase activity
OLD84_02500	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
OLD84_02505	COG1271	oxidase subunit
OLD84_02510	COG1294	oxidase, subunit
OLD84_02515	COG4988	ABC transporter
OLD84_02520	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
OLD84_02525	COG2268	Band 7 protein
OLD84_02530	COG0436	Aminotransferase
OLD84_02545	COG3246	L-lysine catabolic process to acetate
OLD84_02550	COG1250	3-hydroxyacyl-CoA dehydrogenase
OLD84_02555	COG0824	Thioesterase
OLD84_02555	COG1250	3-hydroxyacyl-CoA dehydrogenase
OLD84_02565	COG1174	glycine betaine transport
OLD84_02570	COG1732	Glycine betaine
OLD84_02575	COG1174	glycine betaine transport
OLD84_02585	COG0564	pseudouridine synthase activity
OLD84_02595	COG0628	permease
OLD84_02600	COG1114	Component of the transport system for branched-chain amino acids
OLD84_02605	COG1802	Transcriptional regulator
OLD84_02610	COG0204	Acyl-transferase
OLD84_02620	COG1131	(ABC) transporter
OLD84_02625	COG3559	Exporter of polyketide antibiotics
OLD84_02695	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
OLD84_02700	COG0789	Transcriptional regulator
OLD84_02705	COG1132	(ABC) transporter
OLD84_02710	COG0604	alcohol dehydrogenase
OLD84_02760	COG1131	(ABC) transporter
OLD84_02765	COG1609	Transcriptional regulator
OLD84_02770	COG0803	Belongs to the bacterial solute-binding protein 9 family
OLD84_02775	COG1121	(ABC) transporter
OLD84_02780	COG1108	ABC-type Mn2 Zn2 transport systems permease components
OLD84_02780	COG1321	iron dependent repressor
OLD84_02785	COG1108	ABC-type Mn2 Zn2 transport systems permease components
OLD84_02795	COG0753	catalase activity
OLD84_02810	COG2514	catechol 2,3-dioxygenase activity
OLD84_02815	COG0400	carboxylic ester hydrolase activity
OLD84_02820	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
OLD84_02825	COG0346	lactoylglutathione lyase activity
OLD84_02830	COG1846	Transcriptional regulator
OLD84_02845	COG0667	Aldo Keto reductase
OLD84_02850	COG2910	NAD(P)H-binding
OLD84_02860	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
OLD84_02870	COG0488	(ABC) transporter
OLD84_02875	COG1607	acyl-coa hydrolase
OLD84_02880	COG1473	amidohydrolase
OLD84_02940	COG1704	LemA family
OLD84_02950	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
OLD84_02955	COG0083	homoserine kinase activity
OLD84_02960	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
OLD84_02965	COG0460	homoserine dehydrogenase
OLD84_02970	COG2814	Major facilitator Superfamily
OLD84_02985	COG1562	ergosterol biosynthetic process
OLD84_02990	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
OLD84_03005	COG0352	thiamine-phosphate diphosphorylase activity
OLD84_03010	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
OLD84_03025	COG1505	serine-type exopeptidase activity
OLD84_03040	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
OLD84_03045	COG0693	protein deglycase activity
OLD84_03065	COG1131	(ABC) transporter
OLD84_03075	COG5506	Protein of unknown function (DUF1694)
OLD84_03090	COG5577	PFAM Coat F domain
OLD84_03100	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
OLD84_03120	COG0708	Exodeoxyribonuclease III
OLD84_03125	COG1725	Transcriptional regulator
OLD84_03130	COG1131	(ABC) transporter
OLD84_03160	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
OLD84_03195	COG0673	inositol 2-dehydrogenase activity
OLD84_03225	COG1288	antiporter activity
OLD84_03230	COG1473	amidohydrolase
OLD84_03240	COG0500	methyltransferase
OLD84_03265	COG5504	Zn-dependent protease
OLD84_03275	COG2226	methyltransferase
OLD84_03285	COG0745	RESPONSE REGULATOR receiver
OLD84_03295	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
OLD84_03300	COG0095	Lipoate-protein ligase
OLD84_03305	COG0159	tryptophan synthase activity
OLD84_03310	COG0133	tryptophan synthase activity
OLD84_03315	COG0135	phosphoribosylanthranilate isomerase activity
OLD84_03320	COG0134	indole-3-glycerol-phosphate synthase activity
OLD84_03325	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
OLD84_03330	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
OLD84_03330	COG0512	Glutamine amidotransferase of anthranilate synthase
OLD84_03335	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
OLD84_03340	COG1181	Belongs to the D-alanine--D-alanine ligase family
OLD84_03345	COG0778	Nitroreductase
OLD84_03365	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
OLD84_03365	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
OLD84_03365	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
OLD84_03370	COG1105	Belongs to the carbohydrate kinase PfkB family
OLD84_03375	COG1349	DNA-binding transcription factor activity
OLD84_03385	COG1876	peptidase activity
OLD84_03390	COG2195	Cleaves the N-terminal amino acid of tripeptides
OLD84_03400	COG0519	Catalyzes the synthesis of GMP from XMP
OLD84_03405	COG0840	transmembrane signaling receptor activity
OLD84_03415	COG3279	Response regulator of the LytR AlgR family
OLD84_03425	COG0745	RESPONSE REGULATOR receiver
OLD84_03425	COG2972	Histidine kinase
OLD84_03430	COG4129	membrane
OLD84_03440	COG3639	organic phosphonate transmembrane transporter activity
OLD84_03450	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
OLD84_03515	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
OLD84_03530	COG1304	FMN binding
OLD84_03535	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
OLD84_03540	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
OLD84_03545	COG4605	iron ion homeostasis
OLD84_03550	COG4604	ABC transporter, ATP-binding protein
OLD84_03555	COG4607	ABC-type enterochelin transport system periplasmic component
OLD84_03565	COG0583	DNA-binding transcription factor activity
OLD84_03570	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
OLD84_03575	COG0140	phosphoribosyl-ATP diphosphatase activity
OLD84_03575	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
OLD84_03580	COG0107	imidazoleglycerol-phosphate synthase activity
OLD84_03585	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
OLD84_03590	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
OLD84_03595	COG0131	Imidazoleglycerol-phosphate dehydratase
OLD84_03600	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
OLD84_03605	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
OLD84_03610	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
OLD84_03615	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
OLD84_03625	COG0812	UDP-N-acetylmuramate dehydrogenase activity
OLD84_03630	COG1126	abc transporter atp-binding protein
OLD84_03635	COG0765	amino acid transport
OLD84_03640	COG0765	amino acid transport
OLD84_03650	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
OLD84_03660	COG0673	inositol 2-dehydrogenase activity
OLD84_03670	COG2070	2-Nitropropane dioxygenase
OLD84_03675	COG0346	lactoylglutathione lyase activity
OLD84_03680	COG1876	peptidase activity
OLD84_03685	COG1904	glucuronate isomerase
OLD84_03690	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
OLD84_03700	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
OLD84_03705	COG1803	Methylglyoxal synthase
OLD84_03710	COG0673	inositol 2-dehydrogenase activity
OLD84_03715	COG0673	inositol 2-dehydrogenase activity
OLD84_03730	COG1802	Transcriptional regulator
OLD84_03735	COG1063	alcohol dehydrogenase
OLD84_03750	COG1486	melibiose metabolic process
OLD84_03775	COG0110	maltose O-acetyltransferase activity
OLD84_03785	COG0561	phosphatase activity
OLD84_03790	COG2133	pyrroloquinoline quinone binding
OLD84_03800	COG1064	alcohol dehydrogenase
OLD84_03805	COG0789	Transcriptional regulator
OLD84_03820	COG1070	Carbohydrate kinase
OLD84_03825	COG1691	(AIR) carboxylase
OLD84_03830	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
OLD84_03845	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
OLD84_03865	COG2814	Major facilitator Superfamily
OLD84_03870	COG2207	Transcriptional regulator
OLD84_03870	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
OLD84_03875	COG2211	Major facilitator Superfamily
OLD84_03880	COG0831	urea catabolic process
OLD84_03885	COG0832	Belongs to the urease beta subunit family
OLD84_03895	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
OLD84_03900	COG0830	nickel cation binding
OLD84_03905	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
OLD84_03910	COG0829	nickel cation binding
OLD84_03925	COG0601	transmembrane transport
OLD84_03940	COG1606	tRNA processing
OLD84_03945	COG2839	Protein conserved in bacteria
OLD84_03950	COG0351	phosphomethylpyrimidine kinase
OLD84_03955	COG1335	isochorismatase
OLD84_03960	COG1012	belongs to the aldehyde dehydrogenase family
OLD84_03965	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
OLD84_03970	COG0386	Belongs to the glutathione peroxidase family
OLD84_03975	COG1054	Belongs to the UPF0176 family
OLD84_03985	COG1278	Cold shock
OLD84_03990	COG2226	methyltransferase
OLD84_03990	COG0596	Alpha beta hydrolase
OLD84_03990	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
OLD84_04000	COG2084	Dehydrogenase
OLD84_04005	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
OLD84_04010	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
OLD84_04015	COG0745	RESPONSE REGULATOR receiver
OLD84_04020	COG3850	Histidine kinase
OLD84_04020	COG5002	protein histidine kinase activity
OLD84_04025	COG1217	gtp-binding protein TYPA
OLD84_04030	COG1263	PTS System
OLD84_04030	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
OLD84_04035	COG0366	Alpha amylase catalytic
OLD84_04040	COG2188	Transcriptional regulator
OLD84_04055	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
OLD84_04060	COG1131	(ABC) transporter
OLD84_04080	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
OLD84_04095	COG0745	RESPONSE REGULATOR receiver
OLD84_04100	COG3850	Histidine kinase
OLD84_04100	COG5002	protein histidine kinase activity
OLD84_04105	COG3212	peptidase
OLD84_04205	COG2304	oxidoreductase activity
OLD84_04240	COG3212	peptidase
OLD84_04390	COG2304	oxidoreductase activity
OLD84_04490	COG1307	EDD domain protein, DegV family
OLD84_04500	COG0513	Belongs to the DEAD box helicase family
OLD84_04505	COG3402	PFAM membrane-flanked domain
OLD84_04510	COG3428	Bacterial PH domain
OLD84_04515	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
OLD84_04520	COG0705	Rhomboid family
OLD84_04525	COG0736	holo-[acyl-carrier-protein] synthase activity
OLD84_04530	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
OLD84_04530	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
OLD84_04535	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
OLD84_04535	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
OLD84_04540	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
OLD84_04540	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
OLD84_04545	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
OLD84_04555	COG0864	Transcriptional regulator
OLD84_04560	COG2337	Toxic component of a toxin-antitoxin (TA) module
OLD84_04565	COG1366	Belongs to the anti-sigma-factor antagonist family
OLD84_04570	COG1366	Belongs to the anti-sigma-factor antagonist family
OLD84_04575	COG2172	sigma factor antagonist activity
OLD84_04580	COG2208	phosphoserine phosphatase activity
OLD84_04585	COG1366	Belongs to the anti-sigma-factor antagonist family
OLD84_04590	COG2172	sigma factor antagonist activity
OLD84_04595	COG1191	sigma factor activity
OLD84_04600	COG2208	phosphoserine phosphatase activity
OLD84_04605	COG2183	response to ionizing radiation
OLD84_04610	COG0753	catalase activity
OLD84_04615	COG3091	SprT-like family
OLD84_04705	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
OLD84_04710	COG0802	atpase or kinase
OLD84_04715	COG1214	PFAM Peptidase M22, glycoprotease
OLD84_04720	COG0456	acetyltransferase
OLD84_04725	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
OLD84_04735	COG0488	(ABC) transporter
OLD84_04740	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
OLD84_04750	COG1266	CAAX protease self-immunity
OLD84_04755	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
OLD84_04760	COG0459	protein refolding
OLD84_04775	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
OLD84_04800	COG1472	Belongs to the glycosyl hydrolase 3 family
OLD84_04805	COG3773	Cell wall hydrolase
OLD84_04850	COG1518	maintenance of DNA repeat elements
OLD84_04855	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
OLD84_04875	COG3361	conserved protein (COG2071)
OLD84_04885	COG0154	amidase activity
OLD84_04890	COG0753	catalase activity
OLD84_04895	COG0697	spore germination
OLD84_04900	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
OLD84_04905	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
OLD84_04915	COG0697	spore germination
OLD84_04920	COG1937	Protein conserved in bacteria
OLD84_04930	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
OLD84_04945	COG0390	transport system, permease component
OLD84_04950	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
OLD84_04955	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
OLD84_04960	COG0601	transmembrane transport
OLD84_04965	COG0747	negative chemotaxis
OLD84_04970	COG4608	Belongs to the ABC transporter superfamily
OLD84_04975	COG0444	Belongs to the ABC transporter superfamily
OLD84_04995	COG0697	spore germination
OLD84_05000	COG0531	amino acid
OLD84_05010	COG0154	amidase activity
OLD84_05015	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
OLD84_05020	COG0714	Associated with various cellular activities
OLD84_05025	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
OLD84_05030	COG1305	Transglutaminase-like
OLD84_05035	COG0518	GMP synthase (glutamine-hydrolyzing) activity
OLD84_05035	COG0519	Catalyzes the synthesis of GMP from XMP
OLD84_05040	COG2252	PERMEase
OLD84_05050	COG1051	belongs to the nudix hydrolase family
OLD84_05060	COG2814	Major facilitator Superfamily
OLD84_05065	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
OLD84_05070	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
OLD84_05075	COG2258	MOSC domain
OLD84_05080	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
OLD84_05085	COG0656	L-ascorbic acid biosynthetic process
OLD84_05090	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
OLD84_05100	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
OLD84_05105	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
OLD84_05110	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
OLD84_05115	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
OLD84_05120	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
OLD84_05125	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
OLD84_05130	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
OLD84_05135	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
OLD84_05140	COG0138	bifunctional purine biosynthesis protein purh
OLD84_05145	COG0151	Belongs to the GarS family
OLD84_05150	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
OLD84_05155	COG1470	cell adhesion involved in biofilm formation
OLD84_05160	COG4496	protein, YerC YecD
OLD84_05165	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
OLD84_05170	COG0210	DNA helicase
OLD84_05175	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
OLD84_05180	COG4851	CamS sex pheromone cAM373 precursor
OLD84_05185	COG1012	belongs to the aldehyde dehydrogenase family
OLD84_05200	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
OLD84_05205	COG0154	amidase activity
OLD84_05210	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
OLD84_05215	COG1597	lipid kinase activity
OLD84_05220	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
OLD84_05240	COG2816	NAD+ diphosphatase activity
OLD84_05260	COG3385	transposase activity
OLD84_05270	COG1131	(ABC) transporter
OLD84_05275	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
OLD84_05300	COG0109	protoheme IX farnesyltransferase activity
OLD84_05310	COG0166	Belongs to the GPI family
OLD84_05315	COG0564	pseudouridine synthase activity
OLD84_05320	COG1695	Transcriptional regulator
OLD84_05340	COG1131	(ABC) transporter
OLD84_05350	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
OLD84_05350	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
OLD84_05355	COG0307	riboflavin synthase, alpha
OLD84_05360	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
OLD84_05360	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
OLD84_05365	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
OLD84_05370	COG0488	(ABC) transporter
OLD84_05395	COG0733	neurotransmitter:sodium symporter activity
OLD84_05410	COG3844	kynureninase activity
OLD84_05415	COG0028	Belongs to the TPP enzyme family
OLD84_05420	COG1012	belongs to the aldehyde dehydrogenase family
OLD84_05435	COG1012	belongs to the aldehyde dehydrogenase family
OLD84_05440	COG1960	acyl-CoA dehydrogenase activity
OLD84_05445	COG1804	L-carnitine dehydratase bile acid-inducible protein F
OLD84_05455	COG1077	Cell shape determining protein MreB Mrl
OLD84_05460	COG2340	Cysteine-rich secretory protein family
OLD84_05470	COG2239	Acts as a magnesium transporter
OLD84_05475	COG2066	Belongs to the glutaminase family
OLD84_05480	COG2135	peptidase activity
OLD84_05485	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
OLD84_05495	COG1295	ribonuclease BN
OLD84_05510	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
OLD84_05515	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
OLD84_05520	COG0765	amino acid transport
OLD84_05540	COG2056	Na+-H+ antiporter family
OLD84_05550	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
OLD84_05555	COG0542	response to heat
OLD84_05585	COG2333	competence protein COMEC
OLD84_05585	COG0658	competence protein
OLD84_05600	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
OLD84_05605	COG1131	(ABC) transporter
OLD84_05615	COG1396	sequence-specific DNA binding
OLD84_05625	COG1090	epimerase
OLD84_05630	COG2137	regulation of response to DNA damage stimulus
OLD84_05640	COG1988	membrane-bound metal-dependent
OLD84_05645	COG1194	a g-specific adenine glycosylase
OLD84_05655	COG3557	Belongs to the UPF0374 family
OLD84_05660	COG1132	(ABC) transporter
OLD84_05665	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
OLD84_05675	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
OLD84_05685	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
OLD84_05690	COG0735	belongs to the Fur family
OLD84_05800	COG0702	epimerase
OLD84_05805	COG2364	Membrane
OLD84_05820	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
OLD84_05835	COG1227	inorganic diphosphatase activity
OLD84_05845	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
OLD84_05850	COG3275	phosphorelay sensor kinase activity
OLD84_05855	COG3279	Response regulator of the LytR AlgR family
OLD84_05860	COG3162	membrane
OLD84_05865	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
OLD84_05870	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
OLD84_05895	COG4474	Belongs to the UPF0398 family
OLD84_05905	COG1131	(ABC) transporter
OLD84_05955	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
OLD84_05980	COG0456	acetyltransferase
OLD84_05985	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
OLD84_05990	COG0765	amino acid transport
OLD84_05995	COG1126	abc transporter atp-binding protein
OLD84_06000	COG4989	oxidoreductase activity
OLD84_06005	COG2814	Major facilitator Superfamily
OLD84_06010	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
OLD84_06015	COG0346	lactoylglutathione lyase activity
OLD84_06040	COG0288	reversible hydration of carbon dioxide
OLD84_06045	COG3341	Caulimovirus viroplasmin
OLD84_06045	COG0328	RNA-DNA hybrid ribonuclease activity
OLD84_06140	COG0741	lytic transglycosylase activity
OLD84_06140	COG0791	NLP P60 protein
OLD84_06155	COG0737	Belongs to the 5'-nucleotidase family
OLD84_06160	COG3764	Sortase (surface protein transpeptidase)
OLD84_06210	COG3711	transcriptional antiterminator
OLD84_06210	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
OLD84_06215	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
OLD84_06215	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
OLD84_06215	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
OLD84_06220	COG1482	cell wall glycoprotein biosynthetic process
OLD84_06225	COG3385	transposase activity
OLD84_06260	COG3052	prosthetic group binding
OLD84_06280	COG1609	Transcriptional regulator
OLD84_06285	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
OLD84_06290	COG2610	gluconate transmembrane transporter activity
OLD84_06305	COG3924	membrane
OLD84_06310	COG4145	pantothenate transmembrane transporter activity
OLD84_06315	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
OLD84_06320	COG0473	3-isopropylmalate dehydrogenase activity
OLD84_06330	COG1012	belongs to the aldehyde dehydrogenase family
OLD84_06340	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
OLD84_06355	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
OLD84_06360	COG0686	Belongs to the AlaDH PNT family
OLD84_06365	COG1012	belongs to the aldehyde dehydrogenase family
OLD84_06385	COG0583	DNA-binding transcription factor activity
OLD84_06390	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
OLD84_06410	COG0560	Phosphoserine phosphatase
OLD84_06420	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
OLD84_06435	COG1309	transcriptional regulator
OLD84_06440	COG1511	domain protein
OLD84_06445	COG0589	response to stress
OLD84_06455	COG1388	LysM domain
OLD84_06455	COG3584	3D domain protein
OLD84_06470	COG1011	Hydrolase
OLD84_06480	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
OLD84_06485	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
OLD84_06490	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
OLD84_06510	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
OLD84_06535	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
OLD84_06540	COG0006	proline dipeptidase activity
OLD84_06550	COG1802	Transcriptional regulator
OLD84_06555	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
OLD84_06560	COG1012	belongs to the aldehyde dehydrogenase family
OLD84_06565	COG1473	amidohydrolase
OLD84_06570	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
OLD84_06580	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
OLD84_06585	COG0473	3-isopropylmalate dehydrogenase activity
OLD84_06595	COG2176	DNA-directed DNA polymerase activity
OLD84_06610	COG0616	signal peptide processing
OLD84_06615	COG1714	RDD family
OLD84_06625	COG0318	PFAM AMP-dependent synthetase and ligase
OLD84_06645	COG2814	Major facilitator Superfamily
OLD84_06650	COG1073	alpha beta
OLD84_06705	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
OLD84_06710	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
OLD84_06715	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
OLD84_06720	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
OLD84_06725	COG0505	Belongs to the CarA family
OLD84_06730	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
OLD84_06740	COG0823	Involved in the tonB-independent uptake of proteins
OLD84_06740	COG1506	peptidase
OLD84_06740	COG4946	Tricorn protease homolog
OLD84_06770	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
OLD84_06775	COG0567	Dehydrogenase, E1 component
OLD84_06780	COG0508	dehydrogenase complex catalyzes the overall conversion of
OLD84_06785	COG2252	PERMEase
OLD84_06790	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
OLD84_06795	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
OLD84_06805	COG4176	ABC-type proline glycine betaine transport system permease component
OLD84_06810	COG3448	diguanylate cyclase activity
OLD84_06810	COG4175	Glycine betaine
OLD84_06830	COG1191	sigma factor activity
OLD84_06850	COG2801	Transposase and inactivated derivatives
OLD84_06855	COG2963	transposase activity
OLD84_06865	COG1854	S-ribosylhomocysteine lyase activity
OLD84_06870	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
OLD84_06875	COG0626	cystathionine gamma-synthase activity
OLD84_06885	COG1028	Short-chain dehydrogenase reductase Sdr
OLD84_06900	COG1131	(ABC) transporter
OLD84_06905	COG0024	Methionine aminopeptidase
OLD84_06915	COG1757	Na H antiporter
OLD84_06920	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
OLD84_06930	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
OLD84_06955	COG0114	fumarate hydratase activity
OLD84_06965	COG3842	ATPase activity
OLD84_06970	COG2508	Transcriptional regulator
OLD84_06975	COG3679	Belongs to the UPF0342 family
OLD84_06980	COG1024	Enoyl-CoA hydratase
OLD84_06990	COG4152	abc transporter atp-binding protein
OLD84_06995	COG1668	transmembrane transport
OLD84_07000	COG0420	3'-5' exonuclease activity
OLD84_07005	COG4717	serine-type aminopeptidase activity
OLD84_07010	COG1510	regulation of RNA biosynthetic process
OLD84_07015	COG3481	metal-dependent phosphohydrolase, HD sub domain
OLD84_07025	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
OLD84_07040	COG1510	regulation of RNA biosynthetic process
OLD84_07045	COG0517	IMP dehydrogenase activity
OLD84_07045	COG4175	Glycine betaine
OLD84_07050	COG4176	ABC-type proline glycine betaine transport system permease component
OLD84_07055	COG2113	Glycine betaine
OLD84_07060	COG4980	gas vesicle protein
OLD84_07065	COG0537	adenosine 5'-monophosphoramidase activity
OLD84_07070	COG1131	(ABC) transporter
OLD84_07075	COG4473	ABC transporter
OLD84_07080	COG1473	amidohydrolase
OLD84_07090	COG0671	phosphoesterase, PA-phosphatase related
OLD84_07095	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
OLD84_07110	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
OLD84_07115	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
OLD84_07120	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
OLD84_07125	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
OLD84_07130	COG1164	Oligoendopeptidase f
OLD84_07140	COG1234	tRNA 3'-trailer cleavage
OLD84_07145	COG0095	Lipoate-protein ligase
OLD84_07150	COG0318	PFAM AMP-dependent synthetase and ligase
OLD84_07165	COG0398	Pfam SNARE associated Golgi protein
OLD84_07175	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
OLD84_07180	COG1074	ATP-dependent DNA helicase activity
OLD84_07190	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
OLD84_07195	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
OLD84_07210	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
OLD84_07230	COG1307	EDD domain protein, DegV family
OLD84_07235	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
OLD84_07255	COG0561	phosphatase activity
OLD84_07260	COG1073	alpha beta
OLD84_07265	COG2151	metal-sulfur cluster biosynthetic enzyme
OLD84_07270	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
OLD84_07280	COG0535	radical SAM domain protein
OLD84_07305	COG1744	ABC transporter substrate-binding protein PnrA-like
OLD84_07310	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
OLD84_07315	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
OLD84_07330	COG0180	Tryptophanyl-tRNA synthetase
OLD84_07340	COG0456	acetyltransferase
OLD84_07345	COG1393	Belongs to the ArsC family
OLD84_07355	COG3338	carbonate dehydratase activity
OLD84_07380	COG1164	Oligoendopeptidase f
OLD84_07385	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
OLD84_07390	COG2346	COG2346, Truncated hemoglobins
OLD84_07395	COG4116	CYTH
OLD84_07400	COG2357	RelA SpoT domain protein
OLD84_07405	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
OLD84_07410	COG0564	pseudouridine synthase activity
OLD84_07415	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
OLD84_07440	COG2323	membrane
OLD84_07445	COG2153	protein acetylation
OLD84_07450	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
OLD84_07455	COG2382	esterase
OLD84_07460	COG1132	(ABC) transporter
OLD84_07465	COG1132	(ABC) transporter
OLD84_07480	COG1605	Chorismate mutase
OLD84_07480	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
OLD84_07495	COG1272	protein, Hemolysin III
OLD84_07500	COG2239	Acts as a magnesium transporter
OLD84_07510	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
OLD84_07525	COG0419	ATPase involved in DNA repair
OLD84_07540	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
OLD84_07545	COG1733	regulation of RNA biosynthetic process
OLD84_07550	COG3588	fructose-bisphosphate aldolase
OLD84_07555	COG1131	(ABC) transporter
OLD84_07570	COG4585	Histidine kinase
OLD84_07580	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
OLD84_07585	COG0783	Belongs to the Dps family
OLD84_07595	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
OLD84_07600	COG4548	von Willebrand factor, type A
OLD84_07605	COG0714	Associated with various cellular activities
OLD84_07620	COG1063	alcohol dehydrogenase
OLD84_07635	COG0404	The glycine cleavage system catalyzes the degradation of glycine
OLD84_07645	COG3949	Membrane
OLD84_07655	COG1760	l-serine dehydratase
OLD84_07660	COG1760	l-serine dehydratase
OLD84_07670	COG1119	ATPase activity
OLD84_07680	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
OLD84_07685	COG1733	regulation of RNA biosynthetic process
OLD84_07695	COG0431	NADPH-dependent FMN reductase
OLD84_07735	COG1098	S1 RNA binding domain
OLD84_07740	COG2391	methyltransferase activity
OLD84_07760	COG3842	ATPase activity
OLD84_07770	COG1178	ABC-type Fe3 transport system permease component
OLD84_07775	COG3290	protein histidine kinase activity
OLD84_07775	COG3829	transcription factor binding
OLD84_07780	COG1012	belongs to the aldehyde dehydrogenase family
OLD84_07785	COG0506	proline dehydrogenase activity
OLD84_07790	COG1615	UPF0182 protein
OLD84_07800	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
OLD84_07805	COG0431	NADPH-dependent FMN reductase
OLD84_07815	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
OLD84_07855	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
OLD84_07860	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
OLD84_07865	COG0517	IMP dehydrogenase activity
OLD84_07870	COG0753	catalase activity
OLD84_07890	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
OLD84_07905	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
OLD84_07915	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
OLD84_07925	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
OLD84_07935	COG0277	FAD linked oxidase domain protein
OLD84_07945	COG1404	Belongs to the peptidase S8 family
OLD84_07950	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
OLD84_07955	COG1136	(ABC) transporter
OLD84_08035	COG0318	PFAM AMP-dependent synthetase and ligase
OLD84_08050	COG1252	NADH dehydrogenase
OLD84_08060	COG2720	vancomycin resistance protein
OLD84_08065	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
OLD84_08095	COG3859	Proton-coupled thiamine transporter YuaJ
OLD84_08100	COG3069	C4-dicarboxylate transmembrane transporter activity
OLD84_08105	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
OLD84_08110	COG1966	Carbon starvation protein
OLD84_08120	COG0003	Pfam Anion-transporting ATPase
OLD84_08125	COG0604	alcohol dehydrogenase
OLD84_08130	COG2323	membrane
OLD84_08145	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
OLD84_08165	COG0778	Nitroreductase
OLD84_08180	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
OLD84_08190	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
OLD84_08200	COG0681	Belongs to the peptidase S26 family
OLD84_08235	COG1999	signal sequence binding
OLD84_08240	COG1408	metallophosphoesterase
OLD84_08245	COG0517	IMP dehydrogenase activity
OLD84_08255	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
OLD84_08260	COG1132	(ABC) transporter
OLD84_08265	COG1132	(ABC) transporter
OLD84_08270	COG0569	domain protein
OLD84_08275	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
OLD84_08280	COG5503	Protein of unknown function (DUF1447)
OLD84_08285	COG0561	phosphatase activity
OLD84_08290	COG0242	peptide deformylase activity
OLD84_08305	COG0022	dehydrogenase e1 component
OLD84_08330	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
OLD84_08350	COG4476	Belongs to the UPF0223 family
OLD84_08355	COG4493	Belongs to the UPF0637 family
OLD84_08365	COG0483	inositol monophosphate 1-phosphatase activity
OLD84_08390	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
OLD84_08395	COG4838	Belongs to the UPF0358 family
OLD84_08400	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
OLD84_08405	COG1612	heme a metabolic process
OLD84_08410	COG0109	protoheme IX farnesyltransferase activity
OLD84_08415	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
OLD84_08415	COG2010	Cytochrome c
OLD84_08420	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
OLD84_08425	COG1845	cytochrome c oxidase, subunit III
OLD84_08435	COG3336	cytochrome c oxidase
OLD84_08440	COG2322	membrane
OLD84_08455	COG2340	Cysteine-rich secretory protein family
OLD84_08470	COG3679	Belongs to the UPF0342 family
OLD84_08475	COG4471	UPF0298 protein
OLD84_08480	COG0742	ribosomal rna small subunit methyltransferase
OLD84_08485	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
OLD84_08490	COG3314	Sporulation integral membrane protein YlbJ
OLD84_08495	COG3480	Lon protease (S16) C-terminal proteolytic domain
OLD84_08500	COG1323	Belongs to the UPF0348 family
OLD84_08505	COG1399	metal-binding, possibly nucleic acid-binding protein
OLD84_08510	COG0333	Belongs to the bacterial ribosomal protein bL32 family
OLD84_08515	COG1024	Enoyl-CoA hydratase
OLD84_08525	COG0454	-acetyltransferase
OLD84_08530	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
OLD84_08535	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
OLD84_08540	COG2001	Belongs to the MraZ family
OLD84_08545	COG0275	rRNA processing
OLD84_08555	COG0768	penicillin binding
OLD84_08560	COG0768	penicillin binding
OLD84_08565	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
OLD84_08570	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
OLD84_08575	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
OLD84_08580	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
OLD84_08585	COG0772	Belongs to the SEDS family
OLD84_08590	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
OLD84_08595	COG0849	cell division
OLD84_08600	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
OLD84_08610	COG1191	sigma factor activity
OLD84_08615	COG1191	sigma factor activity
OLD84_08620	COG1873	PFAM PRC-barrel domain
OLD84_08625	COG1496	oxidoreductase activity
OLD84_08630	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
OLD84_08635	COG1799	cell septum assembly
OLD84_08640	COG0762	integral membrane protein
OLD84_08645	COG2302	S4 RNA-binding domain
OLD84_08650	COG3599	regulation of cell shape
OLD84_08655	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
OLD84_08660	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
OLD84_08665	COG0564	pseudouridine synthase activity
OLD84_08670	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
OLD84_08675	COG2233	PERMEase
OLD84_08680	COG0540	Belongs to the ATCase OTCase family
OLD84_08685	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
OLD84_08690	COG0505	Belongs to the CarA family
OLD84_08695	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
OLD84_08705	COG0167	dihydroorotate dehydrogenase activity
OLD84_08710	COG0284	orotidine-5'-phosphate decarboxylase activity
OLD84_08715	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
OLD84_08720	COG2226	methyltransferase
OLD84_08725	COG0583	DNA-binding transcription factor activity
OLD84_08730	COG1764	response to oxidative stress
OLD84_08750	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
OLD84_08755	COG1561	YicC-like family, N-terminal region
OLD84_08760	COG2052	Domain of unknown function (DUF370)
OLD84_08765	COG0194	GDP metabolic process
OLD84_08770	COG1758	RNA polymerase activity
OLD84_08775	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
OLD84_08780	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
OLD84_08785	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
OLD84_08790	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
OLD84_08790	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
OLD84_08795	COG0631	protein serine/threonine phosphatase activity
OLD84_08800	COG2815	serine threonine protein kinase
OLD84_08800	COG0515	serine threonine protein kinase
OLD84_08805	COG1162	GTPase activity
OLD84_08810	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
OLD84_08815	COG1564	THIamine pyrophosphokinase
OLD84_08825	COG0227	Belongs to the bacterial ribosomal protein bL28 family
OLD84_08830	COG1302	Protein conserved in bacteria
OLD84_08835	COG1461	Dihydroxyacetone kinase
OLD84_08845	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
OLD84_08850	COG1349	DNA-binding transcription factor activity
OLD84_08855	COG0416	fatty acid biosynthetic process
OLD84_08860	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
OLD84_08865	COG1028	Short-chain dehydrogenase reductase Sdr
OLD84_08870	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
OLD84_08875	COG0571	ribonuclease III activity
OLD84_08880	COG4840	Belongs to the UPF0435 family
OLD84_08885	COG1196	nuclear chromosome segregation
OLD84_08890	COG0552	protein localization to endoplasmic reticulum
OLD84_08895	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
OLD84_08900	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
OLD84_08905	COG0228	four-way junction DNA binding
OLD84_08910	COG1837	Belongs to the UPF0109 family
OLD84_08920	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
OLD84_08925	COG0336	Belongs to the RNA methyltransferase TrmD family
OLD84_08930	COG0335	large ribosomal subunit rRNA binding
OLD84_08945	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
OLD84_08955	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
OLD84_08960	COG0045	succinate-CoA ligase (ADP-forming) activity
OLD84_08965	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
OLD84_08970	COG0758	DNA mediated transformation
OLD84_08975	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
OLD84_08985	COG4974	Belongs to the 'phage' integrase family
OLD84_08990	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
OLD84_08995	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
OLD84_09000	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
OLD84_09005	COG1815	bacterial-type flagellum-dependent cell motility
OLD84_09010	COG1558	bacterial-type flagellum-dependent cell motility
OLD84_09015	COG1677	Flagellar hook-basal body complex protein FliE
OLD84_09020	COG1766	The M ring may be actively involved in energy transduction
OLD84_09025	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
OLD84_09035	COG1157	protein secretion by the type III secretion system
OLD84_09055	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
OLD84_09065	COG4786	Flagellar basal body rod
OLD84_09070	COG1582	Flagellar protein (FlbD)
OLD84_09075	COG1580	Controls the rotational direction of flagella during chemotaxis
OLD84_09080	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
OLD84_09085	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
OLD84_09085	COG1776	CheC inhibitor of MCP methylation
OLD84_09090	COG2201	protein-glutamate methylesterase activity
OLD84_09095	COG3190	flagellar
OLD84_09100	COG1338	Plays a role in the flagellum-specific transport system
OLD84_09105	COG1987	bacterial-type flagellum assembly
OLD84_09110	COG1684	flagellar biosynthetic protein fliR
OLD84_09115	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
OLD84_09120	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
OLD84_09125	COG1419	protein localization to endoplasmic reticulum
OLD84_09130	COG0455	bacterial-type flagellum organization
OLD84_09135	COG2201	protein-glutamate methylesterase activity
OLD84_09140	COG0835	chemotaxis
OLD84_09145	COG1776	CheC inhibitor of MCP methylation
OLD84_09150	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
OLD84_09155	COG1191	sigma factor activity
OLD84_09165	COG0052	Belongs to the universal ribosomal protein uS2 family
OLD84_09170	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
OLD84_09175	COG0528	UMP kinase activity
OLD84_09180	COG0233	cytoplasmic translational termination
OLD84_09185	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
OLD84_09190	COG4589	Belongs to the CDS family
OLD84_09195	COG0750	zinc metalloprotease
OLD84_09200	COG2176	DNA-directed DNA polymerase activity
OLD84_09205	COG0779	Required for maturation of 30S ribosomal subunits
OLD84_09210	COG0195	Participates in both transcription termination and antitermination
OLD84_09215	COG2740	Nucleic-acid-binding protein implicated in transcription termination
OLD84_09220	COG1358	cellular component organization or biogenesis
OLD84_09225	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
OLD84_09230	COG1550	Protein conserved in bacteria
OLD84_09235	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
OLD84_09240	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
OLD84_09245	COG0196	riboflavin kinase activity
OLD84_09250	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
OLD84_09255	COG1185	polyribonucleotide nucleotidyltransferase activity
OLD84_09260	COG0726	polysaccharide deacetylase
OLD84_09265	COG0612	Peptidase, M16
OLD84_09270	COG1873	PFAM PRC-barrel domain
OLD84_09275	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
OLD84_09280	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
OLD84_09285	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
OLD84_09290	COG0527	aspartate kinase activity
OLD84_09300	COG0740	serine-type endopeptidase activity
OLD84_09310	COG1674	ftsk spoiiie
OLD84_09315	COG2188	Transcriptional regulator
OLD84_09320	COG1744	ABC transporter substrate-binding protein PnrA-like
OLD84_09325	COG3845	ABC transporter
OLD84_09330	COG4603	Belongs to the binding-protein-dependent transport system permease family
OLD84_09335	COG1079	Belongs to the binding-protein-dependent transport system permease family
OLD84_09340	COG0612	Peptidase, M16
OLD84_09345	COG0612	Peptidase, M16
OLD84_09350	COG0300	oxidoreductase activity
OLD84_09365	COG1426	Protein conserved in bacteria
OLD84_09370	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
OLD84_09375	COG1058	Belongs to the CinA family
OLD84_09375	COG1546	Belongs to the CinA family
OLD84_09380	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
OLD84_09385	COG1418	mRNA catabolic process
OLD84_09390	COG1692	metallophosphoesterase
OLD84_09395	COG2359	stage V sporulation protein S
OLD84_09400	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
OLD84_09405	COG4550	Control of competence regulator ComK, YlbF/YmcA
OLD84_09415	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
OLD84_09420	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
OLD84_09425	COG0783	Belongs to the Dps family
OLD84_09430	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
OLD84_09435	COG1923	regulation of RNA biosynthetic process
OLD84_09440	COG0464	growth
OLD84_09445	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
OLD84_09450	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
OLD84_09455	COG0789	Transcriptional regulator
OLD84_09460	COG0174	glutamine synthetase
OLD84_09465	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
OLD84_09470	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
OLD84_09475	COG4224	UPF0291 protein
OLD84_09490	COG3763	UPF0154 protein
OLD84_09495	COG4974	Belongs to the 'phage' integrase family
OLD84_09605	COG1802	Transcriptional regulator
OLD84_09605	COG4626	Terminase
OLD84_09725	COG5632	N-Acetylmuramoyl-L-alanine amidase
OLD84_09735	COG0785	Cytochrome C biogenesis protein
OLD84_09740	COG2201	protein-glutamate methylesterase activity
OLD84_09745	COG4846	Membrane protein involved in cytochrome C biogenesis
OLD84_09755	COG4191	Histidine kinase
OLD84_09760	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
OLD84_09765	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
OLD84_09780	COG0824	Thioesterase
OLD84_09790	COG4841	protein insertion into membrane
OLD84_09795	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
OLD84_09800	COG1469	GTP cyclohydrolase I activity
OLD84_09805	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
OLD84_09810	COG1832	CoA-binding protein
OLD84_09815	COG0187	DNA topoisomerase II activity
OLD84_09820	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
OLD84_09825	COG1309	transcriptional regulator
OLD84_09830	COG1960	acyl-CoA dehydrogenase activity
OLD84_09835	COG0439	Biotin carboxylase
OLD84_09840	COG0511	ligase activity, forming carbon-carbon bonds
OLD84_09845	COG1024	Enoyl-CoA hydratase
OLD84_09850	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
OLD84_09855	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
OLD84_09860	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
OLD84_09865	COG3048	D-serine ammonia-lyase activity
OLD84_09875	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
OLD84_09895	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
OLD84_09895	COG0723	plastoquinol--plastocyanin reductase activity
OLD84_09900	COG1254	Belongs to the acylphosphatase family
OLD84_09920	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
OLD84_09920	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
OLD84_09930	COG4479	Belongs to the UPF0346 family
OLD84_09935	COG0805	protein transport
OLD84_09940	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
OLD84_09945	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
OLD84_09950	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
OLD84_09955	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
OLD84_09960	COG0791	NLP P60 protein
OLD84_09960	COG1388	LysM domain
OLD84_09980	COG1755	Isoprenylcysteine carboxyl methyltransferase
OLD84_09985	COG3424	synthase
OLD84_09995	COG0116	Belongs to the methyltransferase superfamily
OLD84_10005	COG3599	regulation of cell shape
OLD84_10010	COG0295	cytidine deaminase activity
OLD84_10035	COG3331	DNA recombination
OLD84_10040	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
OLD84_10040	COG4499	WXG100 protein secretion system (Wss), protein YukC
OLD84_10045	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
OLD84_10050	COG3935	DnaD domain protein
OLD84_10055	COG0017	Asparaginyl-tRNA synthetase
OLD84_10060	COG0436	Aminotransferase
OLD84_10070	COG1199	ATP-dependent helicase activity
OLD84_10070	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
OLD84_10075	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
OLD84_10080	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
OLD84_10090	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
OLD84_10090	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
OLD84_10095	COG0617	tRNA 3'-terminal CCA addition
OLD84_10100	COG0438	transferase activity, transferring glycosyl groups
OLD84_10105	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
OLD84_10110	COG1694	Mazg nucleotide pyrophosphohydrolase
OLD84_10115	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
OLD84_10120	COG2738	Putative neutral zinc metallopeptidase
OLD84_10130	COG4347	Protein of unknown function (DUF1405)
OLD84_10140	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
OLD84_10145	COG0723	plastoquinol--plastocyanin reductase activity
OLD84_10155	COG5582	Belongs to the UPF0302 family
OLD84_10165	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
OLD84_10170	COG0287	Prephenate dehydrogenase
OLD84_10175	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
OLD84_10180	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
OLD84_10185	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
OLD84_10190	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
OLD84_10195	COG0105	UTP biosynthetic process
OLD84_10200	COG0142	geranyltranstransferase activity
OLD84_10205	COG2226	methyltransferase
OLD84_10210	COG0142	geranyltranstransferase activity
OLD84_10215	COG0776	regulation of translation
OLD84_10220	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
OLD84_10240	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
OLD84_10245	COG1160	GTP binding
OLD84_10260	COG0539	negative regulation of cytoplasmic translation
OLD84_10270	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
OLD84_10275	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
OLD84_10280	COG2959	enzyme of heme biosynthesis
OLD84_10285	COG3409	Peptidoglycan-binding domain 1 protein
OLD84_10285	COG3773	Cell wall hydrolase
OLD84_10290	COG0252	asparaginase activity
OLD84_10295	COG0492	ferredoxin-NADP+ reductase activity
OLD84_10300	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
OLD84_10305	COG4862	establishment of competence for transformation
OLD84_10320	COG0514	ATP-dependent DNA helicase (RecQ)
OLD84_10340	COG5002	protein histidine kinase activity
OLD84_10345	COG0745	RESPONSE REGULATOR receiver
OLD84_10350	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
OLD84_10355	COG1333	cytochrome c biogenesis protein
OLD84_10360	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
OLD84_10365	COG1187	pseudouridine synthase activity
OLD84_10370	COG0700	Nucleoside recognition
OLD84_10375	COG2715	membrane protein required for spore maturation
OLD84_10380	COG1686	Belongs to the peptidase S11 family
OLD84_10385	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
OLD84_10390	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
OLD84_10395	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
OLD84_10400	COG0456	acetyltransferase
OLD84_10410	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
OLD84_10420	COG0697	spore germination
OLD84_10440	COG2172	sigma factor antagonist activity
OLD84_10450	COG1686	Belongs to the peptidase S11 family
OLD84_10465	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
OLD84_10470	COG4974	Belongs to the 'phage' integrase family
OLD84_10480	COG0735	belongs to the Fur family
OLD84_10485	COG1300	Membrane
OLD84_10490	COG1379	DNA repair
OLD84_10500	COG0667	Aldo Keto reductase
OLD84_10505	COG0300	oxidoreductase activity
OLD84_10510	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
OLD84_10515	COG4187	Peptidase family M20/M25/M40
OLD84_10520	COG0584	glycerophosphoryl diester phosphodiesterase
OLD84_10525	COG1234	tRNA 3'-trailer cleavage
OLD84_10530	COG1012	belongs to the aldehyde dehydrogenase family
OLD84_10535	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
OLD84_10540	COG2195	Cleaves the N-terminal amino acid of tripeptides
OLD84_10545	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
OLD84_10550	COG0346	lactoylglutathione lyase activity
OLD84_10555	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
OLD84_10555	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
OLD84_10565	COG4129	membrane
OLD84_10575	COG0508	dehydrogenase complex catalyzes the overall conversion of
OLD84_10580	COG0022	dehydrogenase e1 component
OLD84_10585	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
OLD84_10590	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
OLD84_10605	COG0280	phosphate acetyltransferase
OLD84_10610	COG3290	protein histidine kinase activity
OLD84_10610	COG3829	transcription factor binding
OLD84_10620	COG0527	aspartate kinase activity
OLD84_10625	COG0745	RESPONSE REGULATOR receiver
OLD84_10630	COG0750	zinc metalloprotease
OLD84_10635	COG0497	DNA recombination
OLD84_10640	COG1438	arginine binding
OLD84_10645	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
OLD84_10660	COG1722	exodeoxyribonuclease VII activity
OLD84_10665	COG1570	exodeoxyribonuclease VII activity
OLD84_10670	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
OLD84_10675	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
OLD84_10680	COG1302	Protein conserved in bacteria
OLD84_10685	COG0439	Biotin carboxylase
OLD84_10690	COG0511	ligase activity, forming carbon-carbon bonds
OLD84_10730	COG3854	ATPases associated with a variety of cellular activities
OLD84_10735	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
OLD84_10740	COG0006	proline dipeptidase activity
OLD84_10755	COG1752	Esterase of the alpha-beta hydrolase superfamily
OLD84_10760	COG1321	iron dependent repressor
OLD84_10780	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
OLD84_10790	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
OLD84_10795	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
OLD84_10800	COG0404	The glycine cleavage system catalyzes the degradation of glycine
OLD84_10805	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
OLD84_10820	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
OLD84_10830	COG4537	Required for transformation and DNA binding
OLD84_10865	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
OLD84_10875	COG1368	sulfuric ester hydrolase activity
OLD84_10880	COG1940	carbohydrate kinase activity
OLD84_10890	COG0457	Tetratricopeptide repeat
OLD84_10890	COG0705	Rhomboid family
OLD84_10900	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
OLD84_10905	COG0267	Belongs to the bacterial ribosomal protein bL33 family
OLD84_10935	COG0768	penicillin binding
OLD84_10940	COG0477	Major facilitator Superfamily
OLD84_10945	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
OLD84_10980	COG0704	Plays a role in the regulation of phosphate uptake
OLD84_10995	COG4709	membrane
OLD84_11005	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
OLD84_11015	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
OLD84_11020	COG2384	SAM-dependent methyltransferase
OLD84_11030	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
OLD84_11035	COG0358	DNA primase activity
OLD84_11040	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
OLD84_11045	COG0517	IMP dehydrogenase activity
OLD84_11050	COG0751	glycine-tRNA ligase activity
OLD84_11055	COG0752	glycyl-tRNA synthetase alpha subunit
OLD84_11060	COG1381	Involved in DNA repair and RecF pathway recombination
OLD84_11070	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
OLD84_11080	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
OLD84_11085	COG1480	7TM receptor with intracellular HD hydrolase
OLD84_11090	COG1702	phosphate starvation-inducible protein PhoH
OLD84_11110	COG4864	UPF0365 protein
OLD84_11115	COG1030	water channel activity
OLD84_11120	COG1610	YqeY-like protein
OLD84_11125	COG0828	Belongs to the bacterial ribosomal protein bS21 family
OLD84_11130	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
OLD84_11135	COG1385	rRNA (uridine-N3-)-methyltransferase activity
OLD84_11140	COG2264	protein methyltransferase activity
OLD84_11145	COG0484	heat shock protein binding
OLD84_11150	COG0443	Heat shock 70 kDa protein
OLD84_11155	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
OLD84_11160	COG1420	regulation of RNA biosynthetic process
OLD84_11165	COG0481	GTPase activity
OLD84_11175	COG0860	N-Acetylmuramoyl-L-alanine amidase
OLD84_11180	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
OLD84_11185	COG0268	Binds directly to 16S ribosomal RNA
OLD84_11190	COG1466	dna polymerase III delta subunit
OLD84_11200	COG0658	competence protein
OLD84_11200	COG2333	competence protein COMEC
OLD84_11205	COG2131	deaminase
OLD84_11210	COG1555	photosystem II stabilization
OLD84_11210	COG1596	polysaccharide export
OLD84_11215	COG2226	methyltransferase
OLD84_11220	COG0799	negative regulation of ribosome biogenesis
OLD84_11225	COG1713	HD superfamily hydrolase involved in NAD metabolism
OLD84_11230	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
OLD84_11235	COG1534	Rna-binding protein
OLD84_11240	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
OLD84_11245	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
OLD84_11250	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
OLD84_11260	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
OLD84_11260	COG2111	Na H antiporter
OLD84_11265	COG2111	Na H antiporter
OLD84_11270	COG1006	Multisubunit Na H antiporter MnhC subunit
OLD84_11275	COG0651	ATP synthesis coupled electron transport
OLD84_11280	COG1863	multisubunit Na H antiporter MnhE subunit
OLD84_11285	COG2212	antiporter activity
OLD84_11290	COG1320	monovalent cation:proton antiporter activity
OLD84_11300	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
OLD84_11310	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
OLD84_11315	COG0572	uridine kinase
OLD84_11320	COG4122	O-methyltransferase activity
OLD84_11325	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
OLD84_11330	COG3906	Belongs to the UPF0473 family
OLD84_11335	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
OLD84_11340	COG4472	Bacterial protein of unknown function (DUF965)
OLD84_11345	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
OLD84_11350	COG0628	permease
OLD84_11360	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
OLD84_11370	COG0482	sulfurtransferase activity
OLD84_11375	COG1104	cysteine desulfurase activity
OLD84_11380	COG1959	2 iron, 2 sulfur cluster binding
OLD84_11385	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
OLD84_11400	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
OLD84_11405	COG0124	histidyl-tRNA synthetase
OLD84_11415	COG0860	N-Acetylmuramoyl-L-alanine amidase
OLD84_11420	COG1490	D-aminoacyl-tRNA deacylase activity
OLD84_11425	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
OLD84_11430	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
OLD84_11435	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
OLD84_11435	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
OLD84_11440	COG5416	Lipopolysaccharide assembly protein A domain
OLD84_11445	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
OLD84_11445	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
OLD84_11455	COG2244	polysaccharide biosynthetic process
OLD84_11470	COG1862	Preprotein translocase
OLD84_11475	COG0343	queuine tRNA-ribosyltransferase activity
OLD84_11480	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
OLD84_11490	COG2255	four-way junction helicase activity
OLD84_11495	COG0632	four-way junction helicase activity
OLD84_11500	COG0217	transcriptional regulatory protein
OLD84_11510	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
OLD84_11520	COG1388	LysM domain
OLD84_11525	COG0077	Prephenate dehydratase
OLD84_11530	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
OLD84_11540	COG0211	Belongs to the bacterial ribosomal protein bL27 family
OLD84_11545	COG2868	ribosomal protein
OLD84_11550	COG0261	This protein binds to 23S rRNA in the presence of protein L20
OLD84_11555	COG1994	Peptidase M50
OLD84_11565	COG2894	cell division
OLD84_11570	COG0850	regulation of cytokinetic process
OLD84_11585	COG1077	Cell shape determining protein MreB Mrl
OLD84_11590	COG2003	Belongs to the UPF0758 family
OLD84_11600	COG0285	dihydrofolate synthase activity
OLD84_11605	COG0189	ligase activity
OLD84_11615	COG0525	valine-tRNA ligase activity
OLD84_11630	COG1388	LysM domain
OLD84_11630	COG1388	LysM domain
OLD84_11635	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
OLD84_11650	COG0181	hydroxymethylbilane synthase activity
OLD84_11655	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
OLD84_11665	COG0218	Necessary for normal cell division and for the maintenance of normal septation
OLD84_11675	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
OLD84_11680	COG0544	peptidyl-prolyl cis-trans isomerase activity
OLD84_11700	COG0622	Phosphoesterase
OLD84_11705	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
OLD84_11710	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
OLD84_11715	COG5401	PFAM Sporulation and spore germination
OLD84_11720	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
OLD84_11725	COG1846	Transcriptional regulator
OLD84_11735	COG2197	response regulator
OLD84_11740	COG0824	Thioesterase
OLD84_11745	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
OLD84_11750	COG1053	succinate dehydrogenase
OLD84_11755	COG2009	succinate dehydrogenase
OLD84_11760	COG1719	4-vinyl reductase, 4VR
OLD84_11765	COG0322	excinuclease ABC activity
OLD84_11770	COG3118	belongs to the thioredoxin family
OLD84_11775	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
OLD84_11780	COG2086	electron transfer activity
OLD84_11785	COG1024	Enoyl-CoA hydratase
OLD84_11790	COG1309	transcriptional regulator
OLD84_11795	COG0318	PFAM AMP-dependent synthetase and ligase
OLD84_11800	COG1193	negative regulation of DNA recombination
OLD84_11805	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
OLD84_11805	COG1796	DNA polymerase
OLD84_11810	COG1286	toxin biosynthetic process
OLD84_11815	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
OLD84_11820	COG0072	phenylalanine-tRNA ligase activity
OLD84_11820	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
OLD84_11825	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
OLD84_11830	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
OLD84_11845	COG1363	Peptidase, m42
OLD84_11860	COG0398	Pfam SNARE associated Golgi protein
OLD84_11865	COG3326	Membrane
OLD84_11870	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
OLD84_11875	COG0291	Belongs to the bacterial ribosomal protein bL35 family
OLD84_11880	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
OLD84_11885	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
OLD84_11895	COG1484	DNA-dependent DNA replication
OLD84_11900	COG3611	Membrane attachment protein
OLD84_11905	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
OLD84_11915	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
OLD84_11920	COG0237	dephospho-CoA kinase activity
OLD84_11925	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
OLD84_11930	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
OLD84_11930	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
OLD84_11935	COG5002	protein histidine kinase activity
OLD84_11940	COG0745	RESPONSE REGULATOR receiver
OLD84_11950	COG0039	L-malate dehydrogenase activity
OLD84_11955	COG0538	isocitrate dehydrogenase activity
OLD84_11960	COG0372	Belongs to the citrate synthase family
OLD84_11965	COG0628	permease
OLD84_11970	COG3030	protein affecting phage T7 exclusion by the F plasmid
OLD84_11985	COG0825	malonyl-CoA metabolic process
OLD84_11990	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
OLD84_11995	COG2186	Transcriptional regulator
OLD84_12000	COG0281	malic enzyme
OLD84_12005	COG0587	DNA-directed DNA polymerase activity
OLD84_12025	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
OLD84_12035	COG4109	DRTGG domain
OLD84_12045	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
OLD84_12050	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
OLD84_12055	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
OLD84_12060	COG1842	Phage shock protein A
OLD84_12065	COG0006	proline dipeptidase activity
OLD84_12080	COG0589	response to stress
OLD84_12085	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
OLD84_12090	COG0827	DNA restriction-modification system
OLD84_12095	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
OLD84_12100	COG3874	Sporulation protein YtfJ
OLD84_12110	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
OLD84_12115	COG1574	metal-dependent hydrolase with the TIM-barrel fold
OLD84_12125	COG0301	tRNA thio-modification
OLD84_12130	COG1104	cysteine desulfurase activity
OLD84_12135	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
OLD84_12140	COG1309	transcriptional regulator
OLD84_12145	COG1956	GAF domain-containing protein
OLD84_12150	COG2199	diguanylate cyclase activity
OLD84_12150	COG2203	Gaf domain
OLD84_12155	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
OLD84_12165	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
OLD84_12170	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
OLD84_12175	COG0454	-acetyltransferase
OLD84_12180	COG0517	IMP dehydrogenase activity
OLD84_12185	COG0123	including yeast histone deacetylase and acetoin utilization protein
OLD84_12195	COG4980	gas vesicle protein
OLD84_12205	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
OLD84_12215	COG1674	ftsk spoiiie
OLD84_12220	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
OLD84_12225	COG4848	Belongs to the UPF0354 family
OLD84_12230	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
OLD84_12240	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
OLD84_12245	COG1363	Peptidase, m42
OLD84_12255	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
OLD84_12260	COG0220	tRNA (guanine-N7-)-methyltransferase activity
OLD84_12270	COG0510	thiamine kinase activity
OLD84_12275	COG1597	lipid kinase activity
OLD84_12290	COG1187	pseudouridine synthase activity
OLD84_12295	COG2244	polysaccharide biosynthetic process
OLD84_12300	COG2081	HI0933 family
OLD84_12330	COG0495	leucyl-tRNA aminoacylation
OLD84_12335	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
OLD84_12345	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
OLD84_12350	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
OLD84_12355	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
OLD84_12360	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
OLD84_12365	COG1116	anion transmembrane transporter activity
OLD84_12370	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
OLD84_12375	COG0494	nUDIX hydrolase
OLD84_12390	COG0318	PFAM AMP-dependent synthetase and ligase
OLD84_12395	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
OLD84_12400	COG0596	Alpha beta hydrolase
OLD84_12405	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
OLD84_12410	COG1169	isochorismate synthase
OLD84_12415	COG1575	Belongs to the MenA family. Type 1 subfamily
OLD84_12420	COG2050	protein possibly involved in aromatic compounds catabolism
OLD84_12425	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
OLD84_12430	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
OLD84_12435	COG1404	Belongs to the peptidase S8 family
OLD84_12435	COG4412	M6 family metalloprotease domain protein
OLD84_12450	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
OLD84_12455	COG1098	S1 RNA binding domain
OLD84_12460	COG0166	Belongs to the GPI family
OLD84_12465	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
OLD84_12470	COG2032	superoxide dismutase activity
OLD84_12485	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
OLD84_12490	COG0813	purine-nucleoside phosphorylase activity
OLD84_12495	COG1268	BioY protein
OLD84_12500	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
OLD84_12505	COG3584	3D domain protein
OLD84_12515	COG1252	NADH dehydrogenase
OLD84_12520	COG0492	ferredoxin-NADP+ reductase activity
OLD84_12525	COG0316	Belongs to the HesB IscA family
OLD84_12535	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
OLD84_12540	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
OLD84_12545	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
OLD84_12550	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
OLD84_12555	COG0647	UMP catabolic process
OLD84_12560	COG2445	Protein of unknown function DUF86
OLD84_12565	COG0154	amidase activity
OLD84_12575	COG4470	Protein conserved in bacteria
OLD84_12585	COG0739	heme binding
OLD84_12590	COG1757	Na H antiporter
OLD84_12600	COG3377	Domain of unknown function (DUF1805)
OLD84_12605	COG0737	Belongs to the 5'-nucleotidase family
OLD84_12610	COG0730	response to heat
OLD84_12615	COG0719	Fe-S assembly protein
OLD84_12620	COG0822	iron-sulfur transferase activity
OLD84_12625	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
OLD84_12630	COG0719	Fe-S assembly protein
OLD84_12635	COG0396	ATPase activity
OLD84_12645	COG1464	Belongs to the NlpA lipoprotein family
OLD84_12650	COG2011	ABC-type metal ion transport system permease component
OLD84_12655	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
OLD84_12660	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
OLD84_12670	COG0509	glycine decarboxylation via glycine cleavage system
OLD84_12675	COG1393	Belongs to the ArsC family
OLD84_12680	COG1960	acyl-CoA dehydrogenase activity
OLD84_12685	COG0183	Belongs to the thiolase family
OLD84_12690	COG1024	Enoyl-CoA hydratase
OLD84_12690	COG1250	3-hydroxyacyl-CoA dehydrogenase
OLD84_12700	COG1121	(ABC) transporter
OLD84_12705	COG1108	ABC-type Mn2 Zn2 transport systems permease components
OLD84_12710	COG0735	belongs to the Fur family
OLD84_12715	COG2318	DinB family
OLD84_12735	COG0714	Associated with various cellular activities
OLD84_12740	COG1388	LysM domain
OLD84_12740	COG0791	NLP P60 protein
OLD84_12740	COG3103	Sh3 type 3 domain protein
OLD84_12745	COG2224	Isocitrate lyase
OLD84_12750	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
OLD84_12760	COG4129	membrane
OLD84_12765	COG2197	response regulator
OLD84_12770	COG4585	Histidine kinase
OLD84_12775	COG4758	membrane
OLD84_12790	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
OLD84_12795	COG1363	Peptidase, m42
OLD84_12830	COG1122	ATPase activity
OLD84_12880	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
OLD84_12895	COG3773	Cell wall hydrolase
OLD84_12905	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
OLD84_12910	COG0428	transporter
OLD84_12915	COG0557	exoribonuclease II activity
OLD84_12920	COG1647	Serine aminopeptidase, S33
OLD84_12925	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
OLD84_12935	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
OLD84_12945	COG0148	phosphopyruvate hydratase activity
OLD84_12950	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
OLD84_12955	COG0149	triose-phosphate isomerase activity
OLD84_12960	COG0126	phosphoglycerate kinase activity
OLD84_12980	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
OLD84_12990	COG0328	RNA-DNA hybrid ribonuclease activity
OLD84_12995	COG0179	Fumarylacetoacetate (FAA) hydrolase
OLD84_13000	COG2076	Multidrug Resistance protein
OLD84_13010	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
OLD84_13015	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
OLD84_13020	COG0601	transmembrane transport
OLD84_13025	COG0747	negative chemotaxis
OLD84_13030	COG4608	Belongs to the ABC transporter superfamily
OLD84_13035	COG0444	Belongs to the ABC transporter superfamily
OLD84_13040	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
OLD84_13050	COG0740	serine-type endopeptidase activity
OLD84_13055	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
OLD84_13060	COG1481	regulation of sporulation
OLD84_13065	COG0391	Required for morphogenesis under gluconeogenic growth conditions
OLD84_13070	COG1660	Displays ATPase and GTPase activities
OLD84_13075	COG1051	belongs to the nudix hydrolase family
OLD84_13080	COG0492	ferredoxin-NADP+ reductase activity
OLD84_13085	COG0457	Tetratricopeptide repeat
OLD84_13090	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
OLD84_13095	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
OLD84_13100	COG0110	maltose O-acetyltransferase activity
OLD84_13105	COG0546	phosphoglycolate phosphatase activity
OLD84_13110	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
OLD84_13115	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
OLD84_13120	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
OLD84_13125	COG1950	PFAM Membrane protein of
OLD84_13130	COG1983	PspC domain protein
OLD84_13140	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
OLD84_13145	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
OLD84_13150	COG0556	nucleotide-excision repair
OLD84_13155	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
OLD84_13160	COG1408	metallophosphoesterase
OLD84_13165	COG0726	polysaccharide deacetylase
OLD84_13175	COG1063	alcohol dehydrogenase
OLD84_13185	COG1597	lipid kinase activity
OLD84_13215	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
OLD84_13220	COG3409	Peptidoglycan-binding domain 1 protein
OLD84_13220	COG0793	Belongs to the peptidase S41A family
OLD84_13225	COG0739	heme binding
OLD84_13230	COG2177	Part of the ABC transporter FtsEX involved in
OLD84_13235	COG2884	Cell division ATP-binding protein ftsE
OLD84_13240	COG2010	Cytochrome c
OLD84_13250	COG0653	protein targeting
OLD84_13265	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
OLD84_13285	COG1309	transcriptional regulator
OLD84_13295	COG1516	flagellar protein fliS
OLD84_13300	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
OLD84_13305	COG1334	flagellar protein FlaG
OLD84_13310	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
OLD84_13315	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
OLD84_13325	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
OLD84_13330	COG4786	Flagellar basal body rod
OLD84_13330	COG1256	bacterial-type flagellum assembly
OLD84_13355	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
OLD84_13360	COG1307	EDD domain protein, DegV family
OLD84_13365	COG2197	response regulator
OLD84_13370	COG4585	Histidine kinase
OLD84_13375	COG1739	Uncharacterized protein family UPF0029
OLD84_13380	COG0363	glucosamine-6-phosphate deaminase activity
OLD84_13385	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
OLD84_13410	COG0681	Belongs to the peptidase S26 family
OLD84_13430	COG3764	Sortase (surface protein transpeptidase)
OLD84_13435	COG1316	TRANSCRIPTIONal
OLD84_13440	COG0768	penicillin binding
OLD84_13465	COG1012	belongs to the aldehyde dehydrogenase family
OLD84_13475	COG0583	DNA-binding transcription factor activity
OLD84_13485	COG0561	phosphatase activity
OLD84_13495	COG2814	Major facilitator Superfamily
OLD84_13500	COG2807	transmembrane transport
OLD84_13515	COG2358	TRAP transporter, solute receptor (TAXI family
OLD84_13520	COG0840	transmembrane signaling receptor activity
OLD84_13525	COG2201	protein-glutamate methylesterase activity
OLD84_13530	COG0835	chemotaxis
OLD84_13535	COG0643	Histidine kinase
OLD84_13535	COG2198	Histidine kinase
OLD84_13540	COG1360	Flagellar Motor Protein
OLD84_13545	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
OLD84_13550	COG0840	transmembrane signaling receptor activity
OLD84_13555	COG1012	belongs to the aldehyde dehydrogenase family
OLD84_13560	COG2031	fatty acid transporter
OLD84_13565	COG0697	spore germination
OLD84_13575	COG0840	transmembrane signaling receptor activity
OLD84_13620	COG2963	transposase activity
OLD84_13625	COG0010	Belongs to the arginase family
OLD84_13635	COG0395	ABC-type sugar transport system, permease component
OLD84_13640	COG1175	transmembrane transport
OLD84_13650	COG3394	polysaccharide catabolic process
OLD84_13655	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
OLD84_13660	COG3876	Protein conserved in bacteria
OLD84_13665	COG1486	melibiose metabolic process
OLD84_13670	COG2971	BadF BadG BcrA BcrD
OLD84_13675	COG0395	ABC-type sugar transport system, permease component
OLD84_13680	COG1175	transmembrane transport
OLD84_13690	COG3876	Protein conserved in bacteria
OLD84_13700	COG1737	Transcriptional regulator
OLD84_13705	COG2971	BadF BadG BcrA BcrD
OLD84_13710	COG0772	Belongs to the SEDS family
OLD84_13715	COG0772	Belongs to the SEDS family
OLD84_13720	COG1331	Highly conserved protein containing a thioredoxin domain
OLD84_13735	COG1960	acyl-CoA dehydrogenase activity
OLD84_13740	COG0318	PFAM AMP-dependent synthetase and ligase
OLD84_13770	COG1971	Probably functions as a manganese efflux pump
OLD84_13775	COG1028	Short-chain dehydrogenase reductase Sdr
OLD84_13790	COG2996	Protein conserved in bacteria
OLD84_13795	COG1733	regulation of RNA biosynthetic process
OLD84_13800	COG1028	Short-chain dehydrogenase reductase Sdr
OLD84_13840	COG0693	protein deglycase activity
OLD84_13860	COG4895	conserved protein (DUF2196)
OLD84_13880	COG0561	phosphatase activity
OLD84_13885	COG2059	Chromate
OLD84_13890	COG2059	Chromate
OLD84_13895	COG0405	Gamma-glutamyltransferase
OLD84_13900	COG1522	sequence-specific DNA binding
OLD84_13910	COG2271	Major facilitator Superfamily
OLD84_13935	COG4565	transcriptional regulatory protein
OLD84_13940	COG3290	protein histidine kinase activity
OLD84_13945	COG1115	amino acid carrier protein
OLD84_13955	COG2873	o-acetylhomoserine
OLD84_13960	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
OLD84_13965	COG0066	3-isopropylmalate dehydratase activity
OLD84_13970	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
OLD84_13975	COG0473	3-isopropylmalate dehydrogenase activity
OLD84_13980	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
OLD84_13985	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
OLD84_13990	COG0440	acetolactate synthase activity
OLD84_13995	COG0028	Belongs to the TPP enzyme family
OLD84_14000	COG0129	dihydroxy-acid dehydratase activity
OLD84_14005	COG0385	Bile acid
OLD84_14010	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
OLD84_14015	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
OLD84_14020	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
OLD84_14025	COG1063	alcohol dehydrogenase
OLD84_14050	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
OLD84_14070	COG0601	transmembrane transport
OLD84_14075	COG4608	Belongs to the ABC transporter superfamily
OLD84_14085	COG1960	acyl-CoA dehydrogenase activity
OLD84_14090	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
OLD84_14100	COG0463	Glycosyl transferase, family 2
OLD84_14110	COG2076	Multidrug Resistance protein
OLD84_14115	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
OLD84_14145	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
OLD84_14150	COG0656	L-ascorbic acid biosynthetic process
OLD84_14165	COG1116	anion transmembrane transporter activity
OLD84_14180	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
OLD84_14190	COG2186	Transcriptional regulator
OLD84_14200	COG1250	3-hydroxyacyl-CoA dehydrogenase
OLD84_14205	COG1024	Enoyl-CoA hydratase
OLD84_14220	COG2814	Major facilitator Superfamily
OLD84_14245	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
OLD84_14260	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
OLD84_14265	COG1804	L-carnitine dehydratase bile acid-inducible protein F
OLD84_14270	COG0183	Belongs to the thiolase family
OLD84_14285	COG1309	transcriptional regulator
OLD84_14290	COG2030	dehydratase
OLD84_14300	COG1024	Enoyl-CoA hydratase
OLD84_14310	COG0183	Belongs to the thiolase family
OLD84_14330	COG1960	acyl-CoA dehydrogenase activity
OLD84_14340	COG0410	ABC transporter
OLD84_14355	COG0559	Belongs to the binding-protein-dependent transport system permease family
OLD84_14360	COG1028	Short-chain dehydrogenase reductase Sdr
OLD84_14375	COG1024	Enoyl-CoA hydratase
OLD84_14380	COG1250	3-hydroxyacyl-CoA dehydrogenase
OLD84_14385	COG0318	PFAM AMP-dependent synthetase and ligase
OLD84_14395	COG0318	PFAM AMP-dependent synthetase and ligase
OLD84_14405	COG2045	Belongs to the ComB family
OLD84_14420	COG1028	Short-chain dehydrogenase reductase Sdr
OLD84_14430	COG1028	Short-chain dehydrogenase reductase Sdr
OLD84_14445	COG3835	regulator
OLD84_14450	COG1929	Belongs to the glycerate kinase type-1 family
OLD84_14460	COG3875	lactate racemase activity
OLD84_14465	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
OLD84_14480	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
OLD84_14500	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
OLD84_14505	COG1012	belongs to the aldehyde dehydrogenase family
OLD84_14565	COG0492	ferredoxin-NADP+ reductase activity
OLD84_14580	COG0583	DNA-binding transcription factor activity
OLD84_14585	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
OLD84_14585	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
OLD84_14595	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
OLD84_14620	COG1012	belongs to the aldehyde dehydrogenase family
OLD84_14630	COG1012	belongs to the aldehyde dehydrogenase family
OLD84_14665	COG1414	Transcriptional regulator
OLD84_14675	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
OLD84_14685	COG0318	PFAM AMP-dependent synthetase and ligase
OLD84_14690	COG4336	lyase activity
OLD84_14695	COG1984	allophanate hydrolase subunit 2
OLD84_14700	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
OLD84_14705	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
OLD84_14710	COG1914	H( )-stimulated, divalent metal cation uptake system
OLD84_14730	COG3180	Ammonia monooxygenase
OLD84_14735	COG4640	response to antibiotic
OLD84_14770	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
OLD84_14785	COG0531	amino acid
OLD84_14795	COG0640	Transcriptional regulator
OLD84_14805	COG5146	pantothenate kinase activity
OLD84_14815	COG0602	queuosine metabolic process
OLD84_14820	COG0720	synthase
OLD84_14830	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
OLD84_14840	COG0658	competence protein
OLD84_14840	COG2333	competence protein COMEC
OLD84_14850	COG1846	Transcriptional regulator
OLD84_14855	COG2814	Major facilitator Superfamily
OLD84_14860	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
OLD84_14870	COG1757	Na H antiporter
OLD84_14875	COG0788	formyltetrahydrofolate deformylase activity
OLD84_14885	COG3290	protein histidine kinase activity
OLD84_14890	COG4565	transcriptional regulatory protein
OLD84_14895	COG2851	Citrate transporter
OLD84_14905	COG1268	BioY protein
OLD84_14910	COG1263	PTS System
OLD84_14910	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
OLD84_14910	COG2190	(PTS) system
OLD84_14915	COG3711	transcriptional antiterminator
OLD84_14925	COG0471	metal ion transport
OLD84_14930	COG4565	transcriptional regulatory protein
OLD84_14935	COG3290	protein histidine kinase activity
OLD84_14940	COG2200	EAL domain
OLD84_14950	COG2130	NADP-dependent
OLD84_14980	COG3385	transposase activity
OLD84_14995	COG3486	L-lysine 6-monooxygenase (NADPH) activity
OLD84_15040	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
OLD84_15085	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
OLD84_15100	COG4948	Mandelate Racemase Muconate Lactonizing
OLD84_15105	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
OLD84_15110	COG2190	(PTS) system
OLD84_15115	COG1621	beta-fructofuranosidase activity
OLD84_15135	COG2814	Major facilitator Superfamily
OLD84_15150	COG1960	acyl-CoA dehydrogenase activity
OLD84_15155	COG2259	Doxx family
OLD84_15160	COG1464	Belongs to the NlpA lipoprotein family
OLD84_15165	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
OLD84_15170	COG2011	ABC-type metal ion transport system permease component
OLD84_15295	COG2801	Transposase and inactivated derivatives
OLD84_15340	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
OLD84_15365	COG1012	belongs to the aldehyde dehydrogenase family
OLD84_15390	COG4636	protein conserved in cyanobacteria
OLD84_15400	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
OLD84_15405	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
OLD84_15410	COG1012	belongs to the aldehyde dehydrogenase family
OLD84_15415	COG1510	regulation of RNA biosynthetic process
OLD84_15420	COG2113	Glycine betaine
OLD84_15440	COG0579	oxidoreductase
OLD84_15445	COG2186	Transcriptional regulator
OLD84_15460	COG1070	Carbohydrate kinase
OLD84_15470	COG1902	pentaerythritol trinitrate reductase activity
OLD84_15475	COG0584	glycerophosphoryl diester phosphodiesterase
OLD84_15495	COG1404	Belongs to the peptidase S8 family
OLD84_15505	COG0402	S-adenosylhomocysteine deaminase activity
OLD84_15550	COG2851	Citrate transporter
OLD84_15555	COG3829	transcription factor binding
OLD84_15555	COG3290	protein histidine kinase activity
OLD84_15560	COG1288	antiporter activity
OLD84_15565	COG1473	amidohydrolase
OLD84_15580	COG4948	Mandelate Racemase Muconate Lactonizing
OLD84_15585	COG3949	Membrane
OLD84_15600	COG1028	Short-chain dehydrogenase reductase Sdr
OLD84_15625	COG0210	DNA helicase
OLD84_15630	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
OLD84_15675	COG2801	Transposase and inactivated derivatives
OLD84_15705	COG2610	gluconate transmembrane transporter activity
OLD84_15720	COG1309	transcriptional regulator
OLD84_15745	COG2801	Transposase and inactivated derivatives
OLD84_15760	COG2801	Transposase and inactivated derivatives
OLD84_15780	COG0297	glycogen (starch) synthase activity
OLD84_15780	COG0438	transferase activity, transferring glycosyl groups
OLD84_15805	COG0438	transferase activity, transferring glycosyl groups
OLD84_15840	COG4464	protein tyrosine phosphatase activity
OLD84_15845	COG4464	protein tyrosine phosphatase activity
OLD84_15850	COG0489	protein tyrosine kinase activity
OLD84_15855	COG3944	biosynthesis protein
OLD84_15860	COG1388	LysM domain
OLD84_15860	COG0791	NLP P60 protein
OLD84_15880	COG4585	Histidine kinase
OLD84_15885	COG2197	response regulator
OLD84_15890	COG1131	(ABC) transporter
OLD84_15925	COG1785	Belongs to the alkaline phosphatase family
OLD84_15935	COG1827	regulation of RNA biosynthetic process
OLD84_15940	COG1104	cysteine desulfurase activity
OLD84_15945	COG0157	Belongs to the NadC ModD family
OLD84_15960	COG0432	Pfam Uncharacterised protein family UPF0047
OLD84_15965	COG1940	carbohydrate kinase activity
OLD84_15970	COG1482	cell wall glycoprotein biosynthetic process
OLD84_15975	COG3711	transcriptional antiterminator
OLD84_15975	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
OLD84_15980	COG2723	6-phospho-beta-galactosidase activity
OLD84_15990	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
OLD84_15995	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
OLD84_16010	COG1556	Lactate utilization protein
OLD84_16015	COG1349	DNA-binding transcription factor activity
OLD84_16020	COG3347	Dehydrogenase
OLD84_16020	COG1028	Short-chain dehydrogenase reductase Sdr
OLD84_16025	COG4806	L-rhamnose isomerase
OLD84_16030	COG1070	Carbohydrate kinase
OLD84_16035	COG3254	rhamnose metabolic process
OLD84_16040	COG2207	Transcriptional regulator
OLD84_16045	COG1929	Belongs to the glycerate kinase type-1 family
OLD84_16060	COG1082	Xylose isomerase domain protein TIM barrel
OLD84_16070	COG0673	inositol 2-dehydrogenase activity
OLD84_16105	COG0395	ABC-type sugar transport system, permease component
OLD84_16110	COG1175	transmembrane transport
OLD84_16115	COG5578	integral membrane protein
OLD84_16135	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
OLD84_16140	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
OLD84_16145	COG2017	converts alpha-aldose to the beta-anomer
OLD84_16155	COG1028	Short-chain dehydrogenase reductase Sdr
OLD84_16160	COG3250	beta-galactosidase activity
OLD84_16165	COG2197	response regulator
OLD84_16170	COG4585	Histidine kinase
OLD84_16185	COG1053	succinate dehydrogenase
OLD84_16190	COG1141	Ferredoxin
OLD84_16195	COG0492	ferredoxin-NADP+ reductase activity
OLD84_16205	COG1028	Short-chain dehydrogenase reductase Sdr
OLD84_16210	COG2124	cytochrome p450
OLD84_16225	COG3940	Belongs to the glycosyl hydrolase 43 family
OLD84_16240	COG3534	alpha-L-arabinofuranosidase
OLD84_16245	COG5578	integral membrane protein
OLD84_16250	COG0395	ABC-type sugar transport system, permease component
OLD84_16255	COG1175	transmembrane transport
OLD84_16265	COG1653	transport
OLD84_16275	COG4214	carbohydrate transport
OLD84_16285	COG4213	ABC transporter substrate-binding protein
OLD84_16290	COG1609	Transcriptional regulator
OLD84_16300	COG0395	ABC-type sugar transport system, permease component
OLD84_16320	COG1609	Transcriptional regulator
OLD84_16330	COG1069	ribulokinase activity
OLD84_16340	COG0667	Aldo Keto reductase
OLD84_16345	COG3693	PFAM glycoside hydrolase, family 10
OLD84_16350	COG1070	Carbohydrate kinase
OLD84_16355	COG2115	Belongs to the xylose isomerase family
OLD84_16360	COG5578	integral membrane protein
OLD84_16365	COG0395	ABC-type sugar transport system, permease component
OLD84_16370	COG1175	transmembrane transport
OLD84_16375	COG1653	transport
OLD84_16380	COG1940	carbohydrate kinase activity
OLD84_16385	COG3507	Belongs to the glycosyl hydrolase 43 family
OLD84_16390	COG1073	alpha beta
OLD84_16395	COG0534	Mate efflux family protein
OLD84_16400	COG0673	inositol 2-dehydrogenase activity
OLD84_16405	COG0673	inositol 2-dehydrogenase activity
OLD84_16415	COG2211	Major facilitator Superfamily
OLD84_16420	COG1070	Carbohydrate kinase
OLD84_16425	COG2115	Belongs to the xylose isomerase family
OLD84_16435	COG0800	Aldolase
OLD84_16440	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
OLD84_16445	COG1028	Short-chain dehydrogenase reductase Sdr
OLD84_16450	COG1312	Catalyzes the dehydration of D-mannonate
OLD84_16460	COG0673	inositol 2-dehydrogenase activity
OLD84_16480	COG0395	ABC-type sugar transport system, permease component
OLD84_16485	COG4209	transmembrane transport
OLD84_16490	COG1653	transport
OLD84_16490	COG1653	transport
OLD84_16495	COG5578	integral membrane protein
OLD84_16515	COG0457	Tetratricopeptide repeat
OLD84_16515	COG0463	Glycosyl transferase, family 2
OLD84_16555	COG1082	Xylose isomerase domain protein TIM barrel
OLD84_16560	COG0673	inositol 2-dehydrogenase activity
OLD84_16565	COG0673	inositol 2-dehydrogenase activity
OLD84_16575	COG0366	Alpha amylase catalytic
OLD84_16580	COG1609	Transcriptional regulator
OLD84_16585	COG3833	ABC-type maltose transport systems, permease component
OLD84_16590	COG1175	transmembrane transport
OLD84_16595	COG2182	Extracellular solute-binding protein
OLD84_16605	COG0246	Mannitol dehydrogenase
OLD84_16610	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
OLD84_16615	COG3711	transcriptional antiterminator
OLD84_16630	COG1405	negative regulation of cell septum assembly
OLD84_16630	COG3012	SEC-C Motif Domain Protein
OLD84_16635	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
OLD84_16650	COG1175	transmembrane transport
OLD84_16655	COG0395	ABC-type sugar transport system, permease component
OLD84_16660	COG1653	transport
OLD84_16665	COG0584	glycerophosphoryl diester phosphodiesterase
OLD84_16670	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
OLD84_16675	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
OLD84_16680	COG1733	regulation of RNA biosynthetic process
OLD84_16700	COG1316	TRANSCRIPTIONal
OLD84_16705	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
OLD84_16710	COG1316	TRANSCRIPTIONal
OLD84_16715	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
OLD84_16720	COG4193	domain, Protein
OLD84_16740	COG0189	ligase activity
OLD84_16740	COG1181	Belongs to the D-alanine--D-alanine ligase family
OLD84_16740	COG2918	glutathione biosynthetic process
OLD84_16755	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
OLD84_16755	COG1181	Belongs to the D-alanine--D-alanine ligase family
OLD84_16760	COG2918	glutathione biosynthetic process
OLD84_16760	COG1181	Belongs to the D-alanine--D-alanine ligase family
OLD84_16765	COG0189	ligase activity
OLD84_16765	COG2918	glutathione biosynthetic process
OLD84_16775	COG0463	Glycosyl transferase, family 2
OLD84_16780	COG0463	Glycosyl transferase, family 2
OLD84_16790	COG1682	transport, permease protein
OLD84_16795	COG1215	transferase activity, transferring glycosyl groups
OLD84_16805	COG0438	transferase activity, transferring glycosyl groups
OLD84_16810	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
OLD84_16815	COG1210	Utp--glucose-1-phosphate uridylyltransferase
OLD84_16850	COG0716	FMN binding
OLD84_16880	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
OLD84_16885	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
OLD84_16890	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
OLD84_16930	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
OLD84_16935	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
OLD84_16945	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
OLD84_16955	COG1309	transcriptional regulator
OLD84_16970	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
OLD84_16980	COG4786	Flagellar basal body rod
OLD84_16985	COG4786	Flagellar basal body rod
OLD84_16990	COG1077	Cell shape determining protein MreB Mrl
OLD84_16995	COG1609	Transcriptional regulator
OLD84_17005	COG0739	heme binding
OLD84_17010	COG2385	sporulation resulting in formation of a cellular spore
OLD84_17015	COG4608	Belongs to the ABC transporter superfamily
OLD84_17020	COG1619	proteins homologs of microcin C7 resistance protein MccF
OLD84_17025	COG4166	transmembrane transport
OLD84_17030	COG0444	Belongs to the ABC transporter superfamily
OLD84_17035	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
OLD84_17040	COG0601	transmembrane transport
OLD84_17045	COG3409	Peptidoglycan-binding domain 1 protein
OLD84_17055	COG2963	transposase activity
OLD84_17080	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
OLD84_17090	COG4836	Membrane
OLD84_17095	COG0355	proton-transporting ATP synthase activity, rotational mechanism
OLD84_17100	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
OLD84_17105	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
OLD84_17110	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
OLD84_17115	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
OLD84_17120	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
OLD84_17125	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
OLD84_17130	COG0356	it plays a direct role in the translocation of protons across the membrane
OLD84_17140	COG1404	Belongs to the peptidase S8 family
OLD84_17150	COG2076	Multidrug Resistance protein
OLD84_17155	COG2076	Multidrug Resistance protein
OLD84_17160	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
OLD84_17165	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
OLD84_17170	COG4475	Protein of unknown function (DUF436)
OLD84_17180	COG1971	Probably functions as a manganese efflux pump
OLD84_17185	COG0009	L-threonylcarbamoyladenylate synthase
OLD84_17205	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
OLD84_17225	COG1435	thymidine kinase activity
OLD84_17230	COG0254	rRNA binding
OLD84_17240	COG1028	Short-chain dehydrogenase reductase Sdr
OLD84_17255	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
OLD84_17260	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
OLD84_17265	COG1494	fructose-1,6-bisphosphatase
OLD84_17270	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
OLD84_17275	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
OLD84_17280	COG0191	fructose-bisphosphate aldolase activity
OLD84_17285	COG2204	response regulator
OLD84_17290	COG0504	CTP synthase activity
OLD84_17295	COG3343	RNA polymerase activity
OLD84_17300	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
OLD84_17300	COG1703	isobutyryl-CoA mutase activity
OLD84_17300	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
OLD84_17305	COG1309	transcriptional regulator
OLD84_17315	COG1960	acyl-CoA dehydrogenase activity
OLD84_17320	COG1960	acyl-CoA dehydrogenase activity
OLD84_17325	COG1250	3-hydroxyacyl-CoA dehydrogenase
OLD84_17330	COG0183	Belongs to the thiolase family
OLD84_17335	COG0247	lactate metabolic process
OLD84_17335	COG2181	nitrate reductase activity
OLD84_17340	COG0018	arginyl-trna synthetase
OLD84_17350	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
OLD84_17360	COG3465	dGTPase activity
OLD84_17365	COG1078	dGTPase activity
OLD84_17370	COG0095	Lipoate-protein ligase
OLD84_17380	COG0280	phosphate acetyltransferase
OLD84_17385	COG3253	May function as heme-dependent peroxidase
OLD84_17400	COG2363	Small membrane protein
OLD84_17420	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
OLD84_17425	COG3314	Sporulation integral membrane protein YlbJ
OLD84_17435	COG3594	Acyltransferase
OLD84_17440	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
OLD84_17445	COG3285	dna ligase
OLD84_17445	COG1793	dna ligase
OLD84_17455	COG1764	response to oxidative stress
OLD84_17490	COG3279	Response regulator of the LytR AlgR family
OLD84_17495	COG0577	efflux transmembrane transporter activity
OLD84_17500	COG1136	(ABC) transporter
OLD84_17505	COG0642	Histidine kinase
OLD84_17510	COG0745	RESPONSE REGULATOR receiver
OLD84_17520	COG2154	pterin-4-alpha-carbinolamine dehydratase
OLD84_17525	COG0861	Integral membrane protein TerC family
OLD84_17530	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
OLD84_17535	COG0628	permease
OLD84_17550	COG1114	Component of the transport system for branched-chain amino acids
OLD84_17555	COG0514	ATP-dependent DNA helicase (RecQ)
OLD84_17585	COG1619	proteins homologs of microcin C7 resistance protein MccF
OLD84_17600	COG2807	transmembrane transport
OLD84_17605	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
OLD84_17615	COG0494	nUDIX hydrolase
OLD84_17645	COG1733	regulation of RNA biosynthetic process
OLD84_17650	COG0010	Belongs to the arginase family
OLD84_17655	COG1228	amidohydrolase
OLD84_17665	COG2986	histidine ammonia-lyase
OLD84_17675	COG1607	acyl-coa hydrolase
OLD84_17680	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
OLD84_17685	COG0626	cystathionine gamma-synthase activity
OLD84_17690	COG2962	Rard protein
OLD84_17700	COG2755	lipolytic protein G-D-S-L family
OLD84_17710	COG1714	RDD family
OLD84_17720	COG0488	(ABC) transporter
OLD84_17730	COG2963	transposase activity
OLD84_17740	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
OLD84_17745	COG0156	8-amino-7-oxononanoate synthase activity
OLD84_17755	COG3583	domain protein
OLD84_17755	COG3584	3D domain protein
OLD84_17760	COG4086	secreted protein
OLD84_17765	COG2814	Major facilitator Superfamily
OLD84_17775	COG1979	alcohol dehydrogenase
OLD84_17780	COG0251	oxidation-reduction process
OLD84_17785	COG0741	lytic transglycosylase activity
OLD84_17795	COG0534	Mate efflux family protein
OLD84_17800	COG0318	PFAM AMP-dependent synthetase and ligase
OLD84_17805	COG0747	negative chemotaxis
OLD84_17810	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
OLD84_17815	COG0601	transmembrane transport
OLD84_17820	COG0444	Belongs to the ABC transporter superfamily
OLD84_17825	COG4608	Belongs to the ABC transporter superfamily
OLD84_17840	COG2358	TRAP transporter, solute receptor (TAXI family
OLD84_17855	COG2814	Major facilitator Superfamily
OLD84_17865	COG2032	superoxide dismutase activity
OLD84_17885	COG2155	Conserved Protein
OLD84_17920	COG0789	Transcriptional regulator
OLD84_17925	COG4152	abc transporter atp-binding protein
OLD84_17935	COG0860	N-Acetylmuramoyl-L-alanine amidase
OLD84_17935	COG3103	Sh3 type 3 domain protein
OLD84_17935	COG4991	sh3 domain protein
OLD84_18025	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
OLD84_18035	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
OLD84_18040	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
OLD84_18050	COG2323	membrane
OLD84_18070	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
OLD84_18100	COG0753	catalase activity
OLD84_18110	COG0820	rRNA (adenine-C2-)-methyltransferase activity
OLD84_18115	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
OLD84_18125	COG2963	transposase activity
OLD84_18135	COG2124	cytochrome p450
OLD84_18140	COG0655	NAD(P)H dehydrogenase (quinone) activity
OLD84_18150	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
OLD84_18160	COG1252	NADH dehydrogenase
OLD84_18175	COG1902	pentaerythritol trinitrate reductase activity
OLD84_18180	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
OLD84_18215	COG2197	response regulator
OLD84_18220	COG4585	Histidine kinase
OLD84_18225	COG3239	Fatty acid desaturase
OLD84_18230	COG2814	Major facilitator Superfamily
OLD84_18235	COG0710	3-dehydroquinate dehydratase activity
OLD84_18245	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
OLD84_18250	COG0573	inorganic phosphate transmembrane transporter activity
OLD84_18255	COG0581	inorganic phosphate transmembrane transporter activity
OLD84_18260	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
OLD84_18275	COG3853	Toxic anion resistance protein (TelA)
OLD84_18280	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
OLD84_18285	COG0702	epimerase
OLD84_18290	COG3695	enzyme binding
OLD84_18295	COG0427	acetyl-CoA hydrolase
OLD84_18300	COG3279	Response regulator of the LytR AlgR family
OLD84_18310	COG1231	oxidoreductase activity
OLD84_18320	COG2311	Membrane
OLD84_18335	COG1231	oxidoreductase activity
OLD84_18350	COG3425	synthase
OLD84_18360	COG0114	fumarate hydratase activity
OLD84_18375	COG1346	cytolysis
OLD84_18380	COG1380	Effector of murein hydrolase LrgA
OLD84_18395	COG1172	Belongs to the binding-protein-dependent transport system permease family
OLD84_18405	COG1879	ABC-type sugar transport system periplasmic component
OLD84_18410	COG1609	Transcriptional regulator
OLD84_18415	COG1082	Xylose isomerase domain protein TIM barrel
OLD84_18440	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
OLD84_18450	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
OLD84_18455	COG3871	stress protein (general stress protein 26)
OLD84_18460	COG0405	Gamma-glutamyltransferase
OLD84_18465	COG1620	l-lactate permease
OLD84_18475	COG0494	nUDIX hydrolase
OLD84_18485	COG1929	Belongs to the glycerate kinase type-1 family
OLD84_18490	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
OLD84_18500	COG0747	negative chemotaxis
OLD84_18505	COG0561	phosphatase activity
OLD84_18510	COG0431	NADPH-dependent FMN reductase
OLD84_18520	COG1393	Belongs to the ArsC family
OLD84_18530	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
OLD84_18535	COG4536	flavin adenine dinucleotide binding
OLD84_18540	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
OLD84_18545	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
OLD84_18550	COG0640	Transcriptional regulator
OLD84_18570	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
OLD84_18585	COG1301	dicarboxylic acid transport
OLD84_18610	COG2719	SpoVR family
OLD84_18620	COG2718	Belongs to the UPF0229 family
OLD84_18625	COG2766	serine protein kinase
OLD84_18645	COG2323	membrane
OLD84_18655	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
OLD84_18680	COG0450	alkyl hydroperoxide reductase
OLD84_18685	COG3634	alkyl hydroperoxide reductase activity
OLD84_18705	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
OLD84_18710	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
OLD84_18730	COG1489	DNA binding
OLD84_18745	COG0579	oxidoreductase
OLD84_18750	COG2323	membrane
OLD84_18765	COG2801	Transposase and inactivated derivatives
OLD84_18785	COG4152	abc transporter atp-binding protein
OLD84_18795	COG4585	Histidine kinase
OLD84_18800	COG2197	response regulator
OLD84_18815	COG0653	protein targeting
OLD84_18820	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
OLD84_18830	COG2801	Transposase and inactivated derivatives
OLD84_18845	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
OLD84_18850	COG0395	ABC-type sugar transport system, permease component
OLD84_18855	COG1175	transmembrane transport
OLD84_18865	COG1554	hydrolase, family 65, central catalytic
OLD84_18890	COG1401	restriction endodeoxyribonuclease activity
OLD84_18910	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
OLD84_18935	COG3559	Exporter of polyketide antibiotics
OLD84_18940	COG1131	(ABC) transporter
OLD84_18945	COG1309	transcriptional regulator
OLD84_18950	COG3173	Aminoglycoside phosphotransferase
OLD84_18960	COG3973	AAA domain
OLD84_18970	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
OLD84_18975	COG2358	TRAP transporter, solute receptor (TAXI family
OLD84_18990	COG1476	TRANSCRIPTIONal
OLD84_19000	COG3708	Transcriptional regulator
OLD84_19000	COG2207	Transcriptional regulator
OLD84_19015	COG2027	D-alanyl-D-alanine carboxypeptidase
OLD84_19030	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
OLD84_19035	COG0406	alpha-ribazole phosphatase activity
OLD84_19050	COG1028	Short-chain dehydrogenase reductase Sdr
OLD84_19060	COG1320	monovalent cation:proton antiporter activity
OLD84_19065	COG2212	antiporter activity
OLD84_19070	COG1863	multisubunit Na H antiporter MnhE subunit
OLD84_19075	COG0651	ATP synthesis coupled electron transport
OLD84_19080	COG1006	Multisubunit Na H antiporter MnhC subunit
OLD84_19085	COG2111	Na H antiporter
OLD84_19090	COG2111	Na H antiporter
OLD84_19090	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
OLD84_19110	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
OLD84_19115	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
OLD84_19120	COG4853	Protein conserved in bacteria
OLD84_19125	COG4863	YycH protein
OLD84_19130	COG5002	protein histidine kinase activity
OLD84_19135	COG0745	RESPONSE REGULATOR receiver
OLD84_19145	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
OLD84_19175	COG0305	Participates in initiation and elongation during chromosome replication
OLD84_19180	COG0359	binds to the 23S rRNA
OLD84_19185	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
OLD84_19190	COG4241	membrane
OLD84_19200	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
OLD84_19205	COG0629	single-stranded DNA binding
OLD84_19210	COG0360	Binds together with S18 to 16S ribosomal RNA
OLD84_19215	COG0012	GTP binding
OLD84_19220	COG4481	Protein conserved in bacteria
OLD84_19225	COG0668	transmembrane transport
OLD84_19230	COG3949	Membrane
OLD84_19250	COG1475	DNA binding
OLD84_19255	COG1192	Involved in chromosome partitioning
OLD84_19260	COG1475	DNA binding
OLD84_19265	COG0357	Ribosomal RNA small subunit methyltransferase G
OLD84_19270	COG0445	tRNA wobble uridine modification
OLD84_19275	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
OLD84_19290	COG1847	R3H domain protein
OLD84_19295	COG0706	membrane insertase activity
OLD84_19300	COG0594	ribonuclease P activity
OLD84_19305	COG0230	Belongs to the bacterial ribosomal protein bL34 family