locus-tag	class	description
CFK40_00005	COG1368	sulfuric ester hydrolase activity
CFK40_00030	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CFK40_00035	COG0583	DNA-binding transcription factor activity
CFK40_00040	COG2855	membrane
CFK40_00050	COG2814	Major facilitator Superfamily
CFK40_00060	COG4085	toxin activity
CFK40_00060	COG1525	nuclease
CFK40_00060	COG0737	Belongs to the 5'-nucleotidase family
CFK40_00070	COG2372	response to copper ion
CFK40_00080	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
CFK40_00080	COG0456	acetyltransferase
CFK40_00085	COG0789	Transcriptional regulator
CFK40_00090	COG0477	Major facilitator Superfamily
CFK40_00105	COG3118	belongs to the thioredoxin family
CFK40_00115	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CFK40_00120	COG1366	Belongs to the anti-sigma-factor antagonist family
CFK40_00145	COG1725	Transcriptional regulator
CFK40_00155	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
CFK40_00180	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CFK40_00185	COG3858	chitin binding
CFK40_00185	COG1388	LysM domain
CFK40_00190	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
CFK40_00205	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
CFK40_00235	COG0110	maltose O-acetyltransferase activity
CFK40_00245	COG1413	lyase activity
CFK40_00250	COG0667	Aldo Keto reductase
CFK40_00260	COG2032	superoxide dismutase activity
CFK40_00270	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CFK40_00275	COG1309	transcriptional regulator
CFK40_00280	COG0861	Integral membrane protein TerC family
CFK40_00285	COG1802	Transcriptional regulator
CFK40_00290	COG1114	Component of the transport system for branched-chain amino acids
CFK40_00295	COG0708	Exodeoxyribonuclease III
CFK40_00305	COG1943	Transposase
CFK40_00315	COG1619	proteins homologs of microcin C7 resistance protein MccF
CFK40_00320	COG1573	uracil-dna glycosylase
CFK40_00325	COG0165	Argininosuccinate lyase
CFK40_00330	COG0137	argininosuccinate synthase activity
CFK40_00335	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CFK40_00340	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CFK40_00345	COG0179	Fumarylacetoacetate (FAA) hydrolase
CFK40_00350	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CFK40_00355	COG0515	serine threonine protein kinase
CFK40_00365	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CFK40_00370	COG0805	protein transport
CFK40_00385	COG4608	Belongs to the ABC transporter superfamily
CFK40_00390	COG0444	Belongs to the ABC transporter superfamily
CFK40_00415	COG0626	cystathionine gamma-synthase activity
CFK40_00445	COG0582	viral genome integration into host DNA
CFK40_00455	COG0431	NADPH-dependent FMN reductase
CFK40_00460	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CFK40_00470	COG1335	isochorismatase
CFK40_00475	COG1522	sequence-specific DNA binding
CFK40_00485	COG2217	Heavy metal translocating P-type atpase
CFK40_00490	COG1937	Protein conserved in bacteria
CFK40_00495	COG1486	melibiose metabolic process
CFK40_00515	COG0702	epimerase
CFK40_00525	COG4221	oxidoreductase activity
CFK40_00535	COG1064	alcohol dehydrogenase
CFK40_00540	COG0789	Transcriptional regulator
CFK40_00545	COG2814	Major facilitator Superfamily
CFK40_00550	COG0583	DNA-binding transcription factor activity
CFK40_00580	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CFK40_00590	COG1136	(ABC) transporter
CFK40_00595	COG0577	efflux transmembrane transporter activity
CFK40_00600	COG5002	protein histidine kinase activity
CFK40_00600	COG3850	Histidine kinase
CFK40_00610	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CFK40_00615	COG4856	YbbR-like protein
CFK40_00620	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
CFK40_00625	COG5662	AntiSigma factor
CFK40_00630	COG1595	DNA-templated transcription, initiation
CFK40_00655	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
CFK40_00695	COG4974	Belongs to the 'phage' integrase family
CFK40_00740	COG0726	polysaccharide deacetylase
CFK40_00755	COG0489	protein tyrosine kinase activity
CFK40_00760	COG0860	N-Acetylmuramoyl-L-alanine amidase
CFK40_00790	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CFK40_00795	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CFK40_00800	COG0101	tRNA pseudouridine synthase activity
CFK40_00805	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
CFK40_00810	COG1122	ATPase activity
CFK40_00815	COG1122	ATPase activity
CFK40_00820	COG0203	ribosomal protein L17
CFK40_00825	COG0202	RNA polymerase activity
CFK40_00830	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CFK40_00835	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CFK40_00840	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CFK40_00845	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CFK40_00850	COG2163	COG2163 Ribosomal protein L14E L6E L27E
CFK40_00855	COG0563	adenylate kinase activity
CFK40_00860	COG0201	protein transport
CFK40_00865	COG0200	Binds to the 23S rRNA
CFK40_00870	COG1841	ribosomal large subunit assembly
CFK40_00875	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CFK40_00880	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CFK40_00885	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CFK40_00890	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CFK40_00895	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CFK40_00900	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CFK40_00905	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CFK40_00910	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CFK40_00915	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CFK40_00920	COG0255	Belongs to the universal ribosomal protein uL29 family
CFK40_00925	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CFK40_00930	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CFK40_00935	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CFK40_00940	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CFK40_00945	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CFK40_00950	COG0089	rRNA binding
CFK40_00955	COG0088	Forms part of the polypeptide exit tunnel
CFK40_00960	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CFK40_00965	COG0051	transcription antitermination factor activity, RNA binding
CFK40_00975	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CFK40_00980	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CFK40_00985	COG0049	tRNA binding
CFK40_00990	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CFK40_00995	COG1358	cellular component organization or biogenesis
CFK40_01000	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CFK40_01005	COG0085	RNA polymerase activity
CFK40_01010	COG2813	Specifically methylates the guanine in position
CFK40_01020	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CFK40_01025	COG0081	regulation of translation
CFK40_01030	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CFK40_01035	COG0250	Participates in transcription elongation, termination and antitermination
CFK40_01040	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CFK40_01045	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CFK40_01055	COG3688	RNA-binding protein containing a PIN domain
CFK40_01060	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CFK40_01070	COG0215	cysteine-tRNA ligase activity
CFK40_01075	COG1045	serine acetyltransferase
CFK40_01080	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CFK40_01085	COG4956	integral membrane protein (PIN domain superfamily)
CFK40_01090	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CFK40_01095	COG0542	response to heat
CFK40_01100	COG3869	Catalyzes the specific phosphorylation of arginine residues in
CFK40_01105	COG3880	PFAM UvrB UvrC protein
CFK40_01115	COG1285	pathogenesis
CFK40_01195	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CFK40_01200	COG1396	sequence-specific DNA binding
CFK40_01205	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CFK40_01210	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CFK40_01215	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CFK40_01220	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CFK40_01230	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
CFK40_01235	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
CFK40_01240	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CFK40_01250	COG0037	tRNA processing
CFK40_01255	COG0515	serine threonine protein kinase
CFK40_01260	COG2304	oxidoreductase activity
CFK40_01265	COG2208	phosphoserine phosphatase activity
CFK40_01275	COG1098	S1 RNA binding domain
CFK40_01300	COG1846	Transcriptional regulator
CFK40_01305	COG2814	Major facilitator Superfamily
CFK40_01310	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
CFK40_01315	COG3956	TIGRFAM MazG family protein
CFK40_01320	COG2244	polysaccharide biosynthetic process
CFK40_01325	COG2002	toxin-antitoxin pair type II binding
CFK40_01330	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CFK40_01340	COG0193	aminoacyl-tRNA hydrolase activity
CFK40_01345	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CFK40_01350	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CFK40_01355	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CFK40_01360	COG2088	sporulation resulting in formation of a cellular spore
CFK40_01365	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CFK40_01370	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CFK40_01380	COG4466	Protein conserved in bacteria
CFK40_01390	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CFK40_01400	COG3584	3D domain protein
CFK40_01400	COG3583	domain protein
CFK40_01405	COG0084	hydrolase, TatD family'
CFK40_01415	COG2002	toxin-antitoxin pair type II binding
CFK40_01420	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CFK40_01425	COG2827	Endonuclease containing a URI domain
CFK40_01430	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
CFK40_01435	COG4467	Involved in initiation control of chromosome replication
CFK40_01440	COG1774	PSP1 C-terminal conserved region
CFK40_01445	COG0470	DNA polymerase III
CFK40_01450	COG1728	Protein conserved in bacteria
CFK40_01455	COG3870	Protein conserved in bacteria
CFK40_01460	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CFK40_01465	COG1982	Orn Lys Arg decarboxylase major
CFK40_01490	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CFK40_01495	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CFK40_01500	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CFK40_01510	COG0590	tRNA wobble adenosine to inosine editing
CFK40_01515	COG1335	isochorismatase
CFK40_01520	COG1388	LysM domain
CFK40_01520	COG3858	chitin binding
CFK40_01525	COG0693	protein deglycase activity
CFK40_01530	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CFK40_01545	COG1428	Deoxynucleoside kinase
CFK40_01550	COG1428	Deoxynucleoside kinase
CFK40_01555	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CFK40_01565	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CFK40_01570	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
CFK40_01575	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
CFK40_01585	COG0517	IMP dehydrogenase activity
CFK40_01585	COG0516	GMP reductase activity
CFK40_01605	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CFK40_01610	COG0187	DNA topoisomerase II activity
CFK40_01620	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CFK40_01625	COG2501	S4 domain
CFK40_01630	COG0592	DNA-directed DNA polymerase activity
CFK40_01635	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CFK40_01640	COG0230	Belongs to the bacterial ribosomal protein bL34 family
CFK40_01645	COG0594	ribonuclease P activity
CFK40_01650	COG0706	membrane insertase activity
CFK40_01655	COG1847	R3H domain protein
CFK40_01660	COG2234	aminopeptidase activity
CFK40_01665	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CFK40_01670	COG0445	tRNA wobble uridine modification
CFK40_01675	COG0357	Ribosomal RNA small subunit methyltransferase G
CFK40_01680	COG1475	DNA binding
CFK40_01685	COG1192	Involved in chromosome partitioning
CFK40_01690	COG1475	DNA binding
CFK40_01695	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CFK40_01710	COG3949	Membrane
CFK40_01715	COG0668	transmembrane transport
CFK40_01720	COG4481	Protein conserved in bacteria
CFK40_01725	COG0012	GTP binding
CFK40_01730	COG0360	Binds together with S18 to 16S ribosomal RNA
CFK40_01735	COG0629	single-stranded DNA binding
CFK40_01740	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CFK40_01750	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
CFK40_01755	COG4149	molybdate abc transporter
CFK40_01760	COG0725	ABC transporter, periplasmic molybdate-binding protein
CFK40_01775	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
CFK40_01780	COG0359	binds to the 23S rRNA
CFK40_01785	COG0305	Participates in initiation and elongation during chromosome replication
CFK40_01790	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CFK40_01795	COG0745	RESPONSE REGULATOR receiver
CFK40_01800	COG5002	protein histidine kinase activity
CFK40_01805	COG4863	YycH protein
CFK40_01810	COG4853	Protein conserved in bacteria
CFK40_01815	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CFK40_01820	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CFK40_01830	COG1132	(ABC) transporter
CFK40_01835	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CFK40_01860	COG4607	ABC-type enterochelin transport system periplasmic component
CFK40_01865	COG4604	ABC transporter, ATP-binding protein
CFK40_01870	COG4605	iron ion homeostasis
CFK40_01875	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CFK40_01885	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CFK40_01920	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CFK40_01990	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
CFK40_02000	COG2113	Glycine betaine
CFK40_02005	COG1510	regulation of RNA biosynthetic process
CFK40_02025	COG0579	oxidoreductase
CFK40_02030	COG3153	acetyltransferase
CFK40_02030	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CFK40_02045	COG0494	nUDIX hydrolase
CFK40_02050	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CFK40_02055	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CFK40_02110	COG2766	serine protein kinase
CFK40_02115	COG2718	Belongs to the UPF0229 family
CFK40_02130	COG2719	SpoVR family
CFK40_02165	COG0861	Integral membrane protein TerC family
CFK40_02200	COG3246	L-lysine catabolic process to acetate
CFK40_02205	COG1510	regulation of RNA biosynthetic process
CFK40_02210	COG1125	glycine betaine transport
CFK40_02210	COG0517	IMP dehydrogenase activity
CFK40_02215	COG1174	glycine betaine transport
CFK40_02220	COG1732	Glycine betaine
CFK40_02225	COG1174	glycine betaine transport
CFK40_02245	COG1937	Protein conserved in bacteria
CFK40_02250	COG2210	Belongs to the sulfur carrier protein TusA family
CFK40_02255	COG0425	Belongs to the sulfur carrier protein TusA family
CFK40_02255	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CFK40_02260	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CFK40_02260	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CFK40_02265	COG0425	Belongs to the sulfur carrier protein TusA family
CFK40_02270	COG0730	response to heat
CFK40_02285	COG0785	Cytochrome C biogenesis protein
CFK40_02290	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CFK40_02300	COG5002	protein histidine kinase activity
CFK40_02315	COG4412	M6 family metalloprotease domain protein
CFK40_02315	COG3291	Pkd domain containing protein
CFK40_02320	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CFK40_02330	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
CFK40_02335	COG1301	dicarboxylic acid transport
CFK40_02340	COG0517	IMP dehydrogenase activity
CFK40_02345	COG2124	cytochrome p450
CFK40_02350	COG1295	ribonuclease BN
CFK40_02365	COG1252	NADH dehydrogenase
CFK40_02370	COG0604	alcohol dehydrogenase
CFK40_02380	COG3239	Fatty acid desaturase
CFK40_02385	COG4585	Histidine kinase
CFK40_02390	COG2197	response regulator
CFK40_02395	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CFK40_02400	COG2010	Cytochrome c
CFK40_02405	COG0655	NAD(P)H dehydrogenase (quinone) activity
CFK40_02415	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CFK40_02430	COG2323	membrane
CFK40_02440	COG2076	Multidrug Resistance protein
CFK40_02445	COG2076	Multidrug Resistance protein
CFK40_02450	COG1309	transcriptional regulator
CFK40_02460	COG1115	amino acid carrier protein
CFK40_02475	COG2226	methyltransferase
CFK40_02485	COG3457	Alanine racemase
CFK40_02490	COG1757	Na H antiporter
CFK40_02495	COG0628	permease
CFK40_02500	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CFK40_02505	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CFK40_02515	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CFK40_02520	COG0860	N-Acetylmuramoyl-L-alanine amidase
CFK40_02560	COG1737	Transcriptional regulator
CFK40_02565	COG2814	Major facilitator Superfamily
CFK40_02570	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CFK40_02580	COG2070	2-Nitropropane dioxygenase
CFK40_02585	COG0741	lytic transglycosylase activity
CFK40_02585	COG0791	NLP P60 protein
CFK40_02590	COG1404	Belongs to the peptidase S8 family
CFK40_02595	COG0251	oxidation-reduction process
CFK40_02600	COG1979	alcohol dehydrogenase
CFK40_02610	COG2814	Major facilitator Superfamily
CFK40_02615	COG4086	secreted protein
CFK40_02625	COG4166	transmembrane transport
CFK40_02630	COG0601	transmembrane transport
CFK40_02635	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CFK40_02640	COG0444	Belongs to the ABC transporter superfamily
CFK40_02645	COG4608	Belongs to the ABC transporter superfamily
CFK40_02650	COG3584	3D domain protein
CFK40_02650	COG1388	LysM domain
CFK40_02655	COG0156	8-amino-7-oxononanoate synthase activity
CFK40_02660	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CFK40_02665	COG0488	(ABC) transporter
CFK40_02685	COG2755	lipolytic protein G-D-S-L family
CFK40_02690	COG2962	Rard protein
CFK40_02695	COG0626	cystathionine gamma-synthase activity
CFK40_02705	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CFK40_02710	COG1607	acyl-coa hydrolase
CFK40_02715	COG1115	amino acid carrier protein
CFK40_02720	COG2986	histidine ammonia-lyase
CFK40_02725	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
CFK40_02730	COG1228	amidohydrolase
CFK40_02735	COG1733	regulation of RNA biosynthetic process
CFK40_02745	COG0514	ATP-dependent DNA helicase (RecQ)
CFK40_02750	COG1114	Component of the transport system for branched-chain amino acids
CFK40_02770	COG0628	permease
CFK40_02775	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CFK40_02780	COG3189	MarR family transcriptional regulator
CFK40_02790	COG1764	response to oxidative stress
CFK40_02795	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CFK40_02805	COG3594	Acyltransferase
CFK40_02825	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CFK40_02840	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CFK40_02850	COG0069	glutamate synthase activity
CFK40_02860	COG2363	Small membrane protein
CFK40_02895	COG1028	Short-chain dehydrogenase reductase Sdr
CFK40_02910	COG0280	phosphate acetyltransferase
CFK40_02915	COG0095	Lipoate-protein ligase
CFK40_02920	COG1078	dGTPase activity
CFK40_02925	COG3465	dGTPase activity
CFK40_02935	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CFK40_02945	COG0010	Belongs to the arginase family
CFK40_02955	COG0018	arginyl-trna synthetase
CFK40_02965	COG2181	nitrate reductase activity
CFK40_02965	COG0247	lactate metabolic process
CFK40_02970	COG0183	Belongs to the thiolase family
CFK40_02975	COG1250	3-hydroxyacyl-CoA dehydrogenase
CFK40_02980	COG1960	acyl-CoA dehydrogenase activity
CFK40_02985	COG1960	acyl-CoA dehydrogenase activity
CFK40_03000	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CFK40_03000	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CFK40_03000	COG1703	isobutyryl-CoA mutase activity
CFK40_03005	COG3343	RNA polymerase activity
CFK40_03010	COG0504	CTP synthase activity
CFK40_03020	COG0191	fructose-bisphosphate aldolase activity
CFK40_03025	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CFK40_03030	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CFK40_03035	COG1494	fructose-1,6-bisphosphatase
CFK40_03040	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CFK40_03045	COG0254	rRNA binding
CFK40_03050	COG1435	thymidine kinase activity
CFK40_03055	COG0069	glutamate synthase activity
CFK40_03060	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CFK40_03080	COG0009	L-threonylcarbamoyladenylate synthase
CFK40_03095	COG1132	(ABC) transporter
CFK40_03100	COG1971	Probably functions as a manganese efflux pump
CFK40_03105	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CFK40_03110	COG0698	ribose 5-phosphate isomerase
CFK40_03115	COG4475	Protein of unknown function (DUF436)
CFK40_03120	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CFK40_03130	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CFK40_03135	COG1404	Belongs to the peptidase S8 family
CFK40_03145	COG0356	it plays a direct role in the translocation of protons across the membrane
CFK40_03150	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CFK40_03155	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CFK40_03160	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CFK40_03165	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CFK40_03175	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CFK40_03180	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CFK40_03185	COG4836	Membrane
CFK40_03195	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CFK40_03200	COG1619	proteins homologs of microcin C7 resistance protein MccF
CFK40_03205	COG4948	Mandelate Racemase Muconate Lactonizing
CFK40_03210	COG0791	NLP P60 protein
CFK40_03215	COG2385	sporulation resulting in formation of a cellular spore
CFK40_03220	COG0739	heme binding
CFK40_03230	COG1609	Transcriptional regulator
CFK40_03235	COG1077	Cell shape determining protein MreB Mrl
CFK40_03240	COG4786	Flagellar basal body rod
CFK40_03245	COG4786	Flagellar basal body rod
CFK40_03255	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CFK40_03335	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CFK40_03360	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CFK40_03375	COG0531	amino acid
CFK40_03380	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CFK40_03400	COG2244	polysaccharide biosynthetic process
CFK40_03405	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
CFK40_03420	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CFK40_03425	COG4193	domain, Protein
CFK40_03430	COG0438	transferase activity, transferring glycosyl groups
CFK40_03435	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
CFK40_03440	COG1682	transport, permease protein
CFK40_03455	COG0584	glycerophosphoryl diester phosphodiesterase
CFK40_03460	COG0728	peptidoglycan biosynthetic process
CFK40_03475	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CFK40_03480	COG1316	TRANSCRIPTIONal
CFK40_03485	COG0584	glycerophosphoryl diester phosphodiesterase
CFK40_03490	COG2027	D-alanyl-D-alanine carboxypeptidase
CFK40_03495	COG2186	Transcriptional regulator
CFK40_03505	COG0579	oxidoreductase
CFK40_03510	COG1522	sequence-specific DNA binding
CFK40_03520	COG0405	Gamma-glutamyltransferase
CFK40_03525	COG2059	Chromate
CFK40_03530	COG2059	Chromate
CFK40_03550	COG0246	Mannitol dehydrogenase
CFK40_03575	COG1473	amidohydrolase
CFK40_03580	COG1473	amidohydrolase
CFK40_03585	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
CFK40_03590	COG1940	carbohydrate kinase activity
CFK40_03600	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
CFK40_03605	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CFK40_03630	COG1940	carbohydrate kinase activity
CFK40_03640	COG1175	transmembrane transport
CFK40_03650	COG0673	inositol 2-dehydrogenase activity
CFK40_03660	COG1609	Transcriptional regulator
CFK40_03665	COG1486	melibiose metabolic process
CFK40_03670	COG1940	carbohydrate kinase activity
CFK40_03680	COG5578	integral membrane protein
CFK40_03685	COG1917	Cupin 2, conserved barrel domain protein
CFK40_03685	COG4977	sequence-specific DNA binding
CFK40_03690	COG4209	transmembrane transport
CFK40_03695	COG0395	ABC-type sugar transport system, permease component
CFK40_03715	COG0383	alpha-mannosidase activity
CFK40_03735	COG3525	Glycosyl hydrolase, family 20, catalytic domain
CFK40_03750	COG1940	carbohydrate kinase activity
CFK40_03760	COG0601	transmembrane transport
CFK40_03765	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CFK40_03770	COG0444	Belongs to the ABC transporter superfamily
CFK40_03775	COG4608	Belongs to the ABC transporter superfamily
CFK40_03810	COG0179	Fumarylacetoacetate (FAA) hydrolase
CFK40_03815	COG1028	Short-chain dehydrogenase reductase Sdr
CFK40_03820	COG1028	Short-chain dehydrogenase reductase Sdr
CFK40_03840	COG0673	inositol 2-dehydrogenase activity
CFK40_03850	COG0673	inositol 2-dehydrogenase activity
CFK40_03860	COG1028	Short-chain dehydrogenase reductase Sdr
CFK40_03865	COG3250	beta-galactosidase activity
CFK40_03885	COG2222	sugar isomerase
CFK40_03900	COG3684	Belongs to the aldolase LacD family
CFK40_03915	COG0402	S-adenosylhomocysteine deaminase activity
CFK40_03920	COG0277	FAD linked oxidase domain protein
CFK40_03940	COG5444	nuclease activity
CFK40_03960	COG0791	NLP P60 protein
CFK40_03960	COG1388	LysM domain
CFK40_03965	COG3944	biosynthesis protein
CFK40_03970	COG0489	protein tyrosine kinase activity
CFK40_03975	COG4464	protein tyrosine phosphatase activity
CFK40_04025	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CFK40_04030	COG0110	maltose O-acetyltransferase activity
CFK40_04035	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CFK40_04040	COG1316	TRANSCRIPTIONal
CFK40_04045	COG0747	negative chemotaxis
CFK40_04050	COG0601	transmembrane transport
CFK40_04060	COG0444	Belongs to the ABC transporter superfamily
CFK40_04065	COG4608	Belongs to the ABC transporter superfamily
CFK40_04075	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CFK40_04130	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CFK40_04135	COG2188	Transcriptional regulator
CFK40_04155	COG1122	ATPase activity
CFK40_04160	COG1122	ATPase activity
CFK40_04175	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CFK40_04185	COG3246	L-lysine catabolic process to acetate
CFK40_04195	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CFK40_04210	COG1802	Transcriptional regulator
CFK40_04225	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CFK40_04240	COG4336	lyase activity
CFK40_04270	COG1301	dicarboxylic acid transport
CFK40_04275	COG4689	acetoacetate decarboxylase
CFK40_04285	COG4689	acetoacetate decarboxylase
CFK40_04300	COG1940	carbohydrate kinase activity
CFK40_04305	COG2115	Belongs to the xylose isomerase family
CFK40_04310	COG1070	Carbohydrate kinase
CFK40_04315	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
CFK40_04320	COG1757	Na H antiporter
CFK40_04335	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CFK40_04340	COG0531	amino acid
CFK40_04345	COG0583	DNA-binding transcription factor activity
CFK40_04350	COG3711	transcriptional antiterminator
CFK40_04350	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CFK40_04355	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CFK40_04355	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CFK40_04355	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CFK40_04360	COG3711	transcriptional antiterminator
CFK40_04360	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CFK40_04365	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CFK40_04365	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CFK40_04365	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CFK40_04370	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CFK40_04375	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CFK40_04380	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
CFK40_04385	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CFK40_04395	COG3037	sugar-specific permease SgaT UlaA
CFK40_04425	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CFK40_04430	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CFK40_04430	COG3711	transcriptional antiterminator
CFK40_04440	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CFK40_04440	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CFK40_04440	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CFK40_04445	COG0383	alpha-mannosidase activity
CFK40_04450	COG1929	Belongs to the glycerate kinase type-1 family
CFK40_04455	COG1482	cell wall glycoprotein biosynthetic process
CFK40_04475	COG0395	ABC-type sugar transport system, permease component
CFK40_04490	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CFK40_04495	COG1447	Phosphotransferase system cellobiose-specific component IIA
CFK40_04505	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CFK40_04510	COG0667	Aldo Keto reductase
CFK40_04520	COG1285	pathogenesis
CFK40_04535	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CFK40_04550	COG1012	belongs to the aldehyde dehydrogenase family
CFK40_04555	COG3718	enzyme involved in inositol metabolism
CFK40_04560	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CFK40_04565	COG3962	Belongs to the TPP enzyme family
CFK40_04575	COG1132	(ABC) transporter
CFK40_04580	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CFK40_04595	COG3192	ethanolamine utilization protein
CFK40_04600	COG4810	utilization protein
CFK40_04610	COG4819	ethanolamine utilization protein
CFK40_04615	COG4303	Ethanolamine ammonia lyase large subunit
CFK40_04620	COG4302	ethanolamine ammonia-lyase activity
CFK40_04625	COG4816	utilization protein
CFK40_04630	COG1454	alcohol dehydrogenase
CFK40_04630	COG1012	belongs to the aldehyde dehydrogenase family
CFK40_04635	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
CFK40_04655	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
CFK40_04660	COG0039	L-malate dehydrogenase activity
CFK40_04665	COG2223	nitrite transmembrane transporter activity
CFK40_04690	COG1126	abc transporter atp-binding protein
CFK40_04695	COG3584	3D domain protein
CFK40_04725	COG2986	histidine ammonia-lyase
CFK40_04725	COG1228	amidohydrolase
CFK40_04740	COG1940	carbohydrate kinase activity
CFK40_04745	COG1840	ABC-type Fe3 transport system, periplasmic component
CFK40_04750	COG3842	ATPase activity
CFK40_04760	COG0165	Argininosuccinate lyase
CFK40_04770	COG2390	Transcriptional regulator
CFK40_04780	COG1063	alcohol dehydrogenase
CFK40_04785	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CFK40_04790	COG2390	Transcriptional regulator
CFK40_04805	COG3732	PTS system glucitol sorbitol-specific
CFK40_04820	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CFK40_04825	COG0022	dehydrogenase e1 component
CFK40_04835	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CFK40_04840	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CFK40_04855	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CFK40_04860	COG1802	Transcriptional regulator
CFK40_04905	COG0747	negative chemotaxis
CFK40_04910	COG0601	transmembrane transport
CFK40_04915	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CFK40_04920	COG0444	Belongs to the ABC transporter superfamily
CFK40_04925	COG4608	Belongs to the ABC transporter superfamily
CFK40_04930	COG0583	DNA-binding transcription factor activity
CFK40_04945	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
CFK40_04975	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
CFK40_04980	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CFK40_04985	COG0697	spore germination
CFK40_04990	COG4638	Rieske (2fe-2S)
CFK40_04995	COG0833	amino acid
CFK40_05000	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CFK40_05015	COG1473	amidohydrolase
CFK40_05025	COG1288	antiporter activity
CFK40_05035	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CFK40_05050	COG3835	regulator
CFK40_05090	COG1028	Short-chain dehydrogenase reductase Sdr
CFK40_05095	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CFK40_05115	COG0110	maltose O-acetyltransferase activity
CFK40_05125	COG0673	inositol 2-dehydrogenase activity
CFK40_05140	COG1609	Transcriptional regulator
CFK40_05145	COG1737	Transcriptional regulator
CFK40_05150	COG0800	Aldolase
CFK40_05170	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
CFK40_05180	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
CFK40_05190	COG1288	antiporter activity
CFK40_05205	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CFK40_05220	COG0493	'glutamate synthase
CFK40_05225	COG0167	dihydroorotate dehydrogenase activity
CFK40_05240	COG2318	DinB family
CFK40_05245	COG0626	cystathionine gamma-synthase activity
CFK40_05260	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CFK40_05265	COG1012	belongs to the aldehyde dehydrogenase family
CFK40_05275	COG4145	pantothenate transmembrane transporter activity
CFK40_05280	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CFK40_05285	COG0473	3-isopropylmalate dehydrogenase activity
CFK40_05290	COG1028	Short-chain dehydrogenase reductase Sdr
CFK40_05295	COG1620	l-lactate permease
CFK40_05300	COG2186	Transcriptional regulator
CFK40_05305	COG0247	lactate metabolic process
CFK40_05310	COG1139	Iron-sulfur cluster binding protein
CFK40_05315	COG1556	Lactate utilization protein
CFK40_05320	COG0583	DNA-binding transcription factor activity
CFK40_05325	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
CFK40_05335	COG0277	FAD linked oxidase domain protein
CFK40_05340	COG0247	lactate metabolic process
CFK40_05345	COG0277	FAD linked oxidase domain protein
CFK40_05355	COG1620	l-lactate permease
CFK40_05360	COG0328	RNA-DNA hybrid ribonuclease activity
CFK40_05365	COG0501	Belongs to the peptidase M48B family
CFK40_05370	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CFK40_05375	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CFK40_05385	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CFK40_05390	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CFK40_05395	COG1473	amidohydrolase
CFK40_05410	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CFK40_05425	COG1917	Cupin 2, conserved barrel domain protein
CFK40_05440	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CFK40_05450	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CFK40_05460	COG0583	DNA-binding transcription factor activity
CFK40_05465	COG0010	Belongs to the arginase family
CFK40_05470	COG0786	glutamate:sodium symporter activity
CFK40_05475	COG4145	pantothenate transmembrane transporter activity
CFK40_05485	COG0066	3-isopropylmalate dehydratase activity
CFK40_05490	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CFK40_05495	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CFK40_05500	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CFK40_05505	COG1802	Transcriptional regulator
CFK40_05535	COG0720	synthase
CFK40_05540	COG0602	queuosine metabolic process
CFK40_05550	COG3949	Membrane
CFK40_05555	COG2508	Transcriptional regulator
CFK40_05555	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
CFK40_05560	COG0686	Belongs to the AlaDH PNT family
CFK40_05565	COG1288	antiporter activity
CFK40_05570	COG1473	amidohydrolase
CFK40_05580	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
CFK40_05590	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CFK40_05595	COG3162	membrane
CFK40_05600	COG3279	Response regulator of the LytR AlgR family
CFK40_05605	COG3275	phosphorelay sensor kinase activity
CFK40_05610	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CFK40_05620	COG2814	Major facilitator Superfamily
CFK40_05640	COG1105	Belongs to the carbohydrate kinase PfkB family
CFK40_05645	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CFK40_05645	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CFK40_05645	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CFK40_05650	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CFK40_05650	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CFK40_05650	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CFK40_05665	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CFK40_05690	COG1735	metal-dependent hydrolase with the TIM-barrel fold
CFK40_05695	COG0626	cystathionine gamma-synthase activity
CFK40_05700	COG3457	Alanine racemase
CFK40_05705	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
CFK40_05735	COG3454	Phosphonate metabolism
CFK40_05740	COG0006	proline dipeptidase activity
CFK40_05745	COG4166	transmembrane transport
CFK40_05750	COG0601	transmembrane transport
CFK40_05755	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CFK40_05760	COG4172	Belongs to the ABC transporter superfamily
CFK40_05770	COG0006	proline dipeptidase activity
CFK40_05775	COG1505	serine-type exopeptidase activity
CFK40_05795	COG3290	protein histidine kinase activity
CFK40_05795	COG3829	transcription factor binding
CFK40_05805	COG3938	Belongs to the proline racemase family
CFK40_05810	COG3938	Belongs to the proline racemase family
CFK40_05815	COG1757	Na H antiporter
CFK40_05820	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CFK40_05825	COG1012	belongs to the aldehyde dehydrogenase family
CFK40_05850	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CFK40_05855	COG3414	Phosphotransferase system galactitol-specific IIB component
CFK40_05860	COG3775	system Galactitol-specific IIC component
CFK40_05865	COG1063	alcohol dehydrogenase
CFK40_05870	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CFK40_05875	COG1063	alcohol dehydrogenase
CFK40_05885	COG0686	Belongs to the AlaDH PNT family
CFK40_05890	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CFK40_05895	COG0583	DNA-binding transcription factor activity
CFK40_05925	COG0473	3-isopropylmalate dehydrogenase activity
CFK40_05935	COG4166	transmembrane transport
CFK40_05940	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
CFK40_05945	COG2368	4-hydroxyphenylacetate
CFK40_05950	COG1960	acyl-CoA dehydrogenase activity
CFK40_05955	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CFK40_05975	COG0367	asparagine synthase
CFK40_05985	COG0702	epimerase
CFK40_05990	COG1609	Transcriptional regulator
CFK40_05995	COG1028	Short-chain dehydrogenase reductase Sdr
CFK40_06000	COG1653	transport
CFK40_06005	COG1653	transport
CFK40_06020	COG0673	inositol 2-dehydrogenase activity
CFK40_06025	COG0673	inositol 2-dehydrogenase activity
CFK40_06040	COG0673	inositol 2-dehydrogenase activity
CFK40_06045	COG1082	Xylose isomerase domain protein TIM barrel
CFK40_06050	COG1827	regulation of RNA biosynthetic process
CFK40_06055	COG1104	cysteine desulfurase activity
CFK40_06060	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
CFK40_06065	COG0157	Belongs to the NadC ModD family
CFK40_06070	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
CFK40_06080	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CFK40_06085	COG2076	Multidrug Resistance protein
CFK40_06095	COG0463	Glycosyl transferase, family 2
CFK40_06100	COG1088	dTDP-glucose 4,6-dehydratase activity
CFK40_06115	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CFK40_06130	COG1136	(ABC) transporter
CFK40_06135	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CFK40_06140	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CFK40_06150	COG0561	phosphatase activity
CFK40_06155	COG0436	Aminotransferase
CFK40_06160	COG4895	conserved protein (DUF2196)
CFK40_06180	COG2094	Belongs to the DNA glycosylase MPG family
CFK40_06185	COG1126	abc transporter atp-binding protein
CFK40_06190	COG0765	amino acid transport
CFK40_06195	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CFK40_06200	COG2996	Protein conserved in bacteria
CFK40_06245	COG1971	Probably functions as a manganese efflux pump
CFK40_06250	COG1959	2 iron, 2 sulfur cluster binding
CFK40_06255	COG1017	nitric oxide dioxygenase activity
CFK40_06255	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CFK40_06260	COG1380	Effector of murein hydrolase LrgA
CFK40_06265	COG1346	cytolysis
CFK40_06275	COG3290	protein histidine kinase activity
CFK40_06280	COG4565	transcriptional regulatory protein
CFK40_06305	COG2079	MmgE PrpD family protein
CFK40_06310	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
CFK40_06320	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CFK40_06340	COG1574	metal-dependent hydrolase with the TIM-barrel fold
CFK40_06355	COG1175	transmembrane transport
CFK40_06360	COG3833	ABC-type maltose transport systems, permease component
CFK40_06370	COG1609	Transcriptional regulator
CFK40_06375	COG0716	FMN binding
CFK40_06380	COG0697	spore germination
CFK40_06385	COG2031	fatty acid transporter
CFK40_06390	COG2971	BadF BadG BcrA BcrD
CFK40_06395	COG1737	Transcriptional regulator
CFK40_06400	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
CFK40_06410	COG1175	transmembrane transport
CFK40_06420	COG3876	Protein conserved in bacteria
CFK40_06425	COG1472	Belongs to the glycosyl hydrolase 3 family
CFK40_06430	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CFK40_06450	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
CFK40_06455	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CFK40_06470	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CFK40_06475	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CFK40_06480	COG1120	ATPase activity
CFK40_06485	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
CFK40_06490	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CFK40_06500	COG1492	cobalamin metabolic process
CFK40_06505	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
CFK40_06520	COG2096	Adenosyltransferase
CFK40_06540	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CFK40_06545	COG0010	Belongs to the arginase family
CFK40_06550	COG1794	racemase activity, acting on amino acids and derivatives
CFK40_06555	COG2807	transmembrane transport
CFK40_06560	COG2814	Major facilitator Superfamily
CFK40_06565	COG0471	metal ion transport
CFK40_06570	COG2814	Major facilitator Superfamily
CFK40_06575	COG0561	phosphatase activity
CFK40_06585	COG1012	belongs to the aldehyde dehydrogenase family
CFK40_06595	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CFK40_06610	COG0768	penicillin binding
CFK40_06615	COG1316	TRANSCRIPTIONal
CFK40_06625	COG1396	sequence-specific DNA binding
CFK40_06630	COG4821	SIS domain
CFK40_06640	COG1263	PTS System
CFK40_06640	COG2190	(PTS) system
CFK40_06640	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CFK40_06650	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CFK40_06655	COG0363	glucosamine-6-phosphate deaminase activity
CFK40_06660	COG1739	Uncharacterized protein family UPF0029
CFK40_06670	COG2197	response regulator
CFK40_06675	COG1307	EDD domain protein, DegV family
CFK40_06680	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
CFK40_06685	COG1040	competence protein
CFK40_06705	COG4786	Flagellar basal body rod
CFK40_06705	COG1256	bacterial-type flagellum assembly
CFK40_06710	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CFK40_06720	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
CFK40_06725	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
CFK40_06730	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
CFK40_06735	COG1516	flagellar protein fliS
CFK40_06750	COG0653	protein targeting
CFK40_06755	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
CFK40_06765	COG2884	Cell division ATP-binding protein ftsE
CFK40_06770	COG2177	Part of the ABC transporter FtsEX involved in
CFK40_06775	COG0739	heme binding
CFK40_06775	COG1196	nuclear chromosome segregation
CFK40_06775	COG0741	lytic transglycosylase activity
CFK40_06780	COG0793	Belongs to the peptidase S41A family
CFK40_06780	COG3409	Peptidoglycan-binding domain 1 protein
CFK40_06785	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CFK40_06795	COG0556	nucleotide-excision repair
CFK40_06800	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CFK40_06805	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CFK40_06815	COG1983	PspC domain protein
CFK40_06820	COG1950	PFAM Membrane protein of
CFK40_06825	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
CFK40_06830	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CFK40_06835	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CFK40_06840	COG0546	phosphoglycolate phosphatase activity
CFK40_06845	COG0110	maltose O-acetyltransferase activity
CFK40_06850	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
CFK40_06855	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CFK40_06860	COG0457	Tetratricopeptide repeat
CFK40_06865	COG0492	ferredoxin-NADP+ reductase activity
CFK40_06870	COG1051	belongs to the nudix hydrolase family
CFK40_06875	COG1660	Displays ATPase and GTPase activities
CFK40_06880	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CFK40_06885	COG1481	regulation of sporulation
CFK40_06890	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CFK40_06895	COG0740	serine-type endopeptidase activity
CFK40_06905	COG2112	serine threonine protein kinase
CFK40_06925	COG0126	phosphoglycerate kinase activity
CFK40_06930	COG0149	triose-phosphate isomerase activity
CFK40_06935	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
CFK40_06940	COG0148	phosphopyruvate hydratase activity
CFK40_06955	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CFK40_06965	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CFK40_06970	COG1647	Serine aminopeptidase, S33
CFK40_06975	COG0557	exoribonuclease II activity
CFK40_06980	COG0428	transporter
CFK40_06985	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CFK40_07000	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CFK40_07010	COG1595	DNA-templated transcription, initiation
CFK40_07050	COG3118	belongs to the thioredoxin family
CFK40_07055	COG0726	polysaccharide deacetylase
CFK40_07060	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
CFK40_07075	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CFK40_07100	COG1363	Peptidase, m42
CFK40_07105	COG1309	transcriptional regulator
CFK40_07115	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CFK40_07125	COG0586	Pfam SNARE associated Golgi protein
CFK40_07130	COG1968	undecaprenyl-diphosphatase activity
CFK40_07140	COG1388	LysM domain
CFK40_07180	COG4585	Histidine kinase
CFK40_07185	COG2197	response regulator
CFK40_07190	COG2224	Isocitrate lyase
CFK40_07195	COG0598	Magnesium transport protein CorA
CFK40_07200	COG0791	NLP P60 protein
CFK40_07200	COG3883	PFAM NLP P60 protein
CFK40_07205	COG0778	Nitroreductase
CFK40_07215	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CFK40_07220	COG1253	flavin adenine dinucleotide binding
CFK40_07225	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CFK40_07230	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CFK40_07235	COG0735	belongs to the Fur family
CFK40_07240	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CFK40_07245	COG1121	(ABC) transporter
CFK40_07255	COG1937	Protein conserved in bacteria
CFK40_07265	COG0506	proline dehydrogenase activity
CFK40_07270	COG1024	Enoyl-CoA hydratase
CFK40_07270	COG1250	3-hydroxyacyl-CoA dehydrogenase
CFK40_07275	COG0183	Belongs to the thiolase family
CFK40_07280	COG1960	acyl-CoA dehydrogenase activity
CFK40_07290	COG1393	Belongs to the ArsC family
CFK40_07295	COG0509	glycine decarboxylation via glycine cleavage system
CFK40_07300	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
CFK40_07310	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CFK40_07315	COG2011	ABC-type metal ion transport system permease component
CFK40_07320	COG1464	Belongs to the NlpA lipoprotein family
CFK40_07325	COG0396	ATPase activity
CFK40_07330	COG0719	Fe-S assembly protein
CFK40_07335	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CFK40_07340	COG0822	iron-sulfur transferase activity
CFK40_07345	COG0719	Fe-S assembly protein
CFK40_07355	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CFK40_07365	COG1012	belongs to the aldehyde dehydrogenase family
CFK40_07370	COG4638	Rieske (2fe-2S)
CFK40_07385	COG1309	transcriptional regulator
CFK40_07390	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CFK40_07400	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CFK40_07400	COG2111	Na H antiporter
CFK40_07410	COG1006	Multisubunit Na H antiporter MnhC subunit
CFK40_07415	COG0651	ATP synthesis coupled electron transport
CFK40_07420	COG1863	multisubunit Na H antiporter MnhE subunit
CFK40_07425	COG2212	antiporter activity
CFK40_07430	COG1320	monovalent cation:proton antiporter activity
CFK40_07435	COG3290	protein histidine kinase activity
CFK40_07440	COG4565	transcriptional regulatory protein
CFK40_07445	COG2851	Citrate transporter
CFK40_07450	COG0730	response to heat
CFK40_07455	COG0737	Belongs to the 5'-nucleotidase family
CFK40_07460	COG3377	Domain of unknown function (DUF1805)
CFK40_07490	COG1757	Na H antiporter
CFK40_07495	COG0733	neurotransmitter:sodium symporter activity
CFK40_07505	COG0739	heme binding
CFK40_07515	COG4470	Protein conserved in bacteria
CFK40_07530	COG2445	Protein of unknown function DUF86
CFK40_07535	COG0647	UMP catabolic process
CFK40_07540	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
CFK40_07545	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CFK40_07550	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
CFK40_07555	COG4837	Protein of unknown function (DUF1462)
CFK40_07560	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CFK40_07565	COG0316	Belongs to the HesB IscA family
CFK40_07575	COG0492	ferredoxin-NADP+ reductase activity
CFK40_07580	COG1252	NADH dehydrogenase
CFK40_07590	COG3584	3D domain protein
CFK40_07595	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
CFK40_07605	COG0813	purine-nucleoside phosphorylase activity
CFK40_07610	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CFK40_07635	COG2032	superoxide dismutase activity
CFK40_07640	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
CFK40_07645	COG0166	Belongs to the GPI family
CFK40_07650	COG1098	S1 RNA binding domain
CFK40_07660	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CFK40_07675	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CFK40_07680	COG2011	ABC-type metal ion transport system permease component
CFK40_07685	COG1464	Belongs to the NlpA lipoprotein family
CFK40_07695	COG4412	M6 family metalloprotease domain protein
CFK40_07695	COG1404	Belongs to the peptidase S8 family
CFK40_07700	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
CFK40_07705	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CFK40_07710	COG2050	protein possibly involved in aromatic compounds catabolism
CFK40_07715	COG1575	Belongs to the MenA family. Type 1 subfamily
CFK40_07720	COG1169	isochorismate synthase
CFK40_07725	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
CFK40_07730	COG0596	Alpha beta hydrolase
CFK40_07735	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
CFK40_07740	COG0318	PFAM AMP-dependent synthetase and ligase
CFK40_07745	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CFK40_07750	COG2076	Multidrug Resistance protein
CFK40_07755	COG2076	Multidrug Resistance protein
CFK40_07785	COG1120	ATPase activity
CFK40_07795	COG0494	nUDIX hydrolase
CFK40_07800	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CFK40_07805	COG1116	anion transmembrane transporter activity
CFK40_07810	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
CFK40_07815	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CFK40_07820	COG3011	Protein conserved in bacteria
CFK40_07825	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
CFK40_07835	COG1126	abc transporter atp-binding protein
CFK40_07845	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CFK40_07850	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
CFK40_07855	COG0495	leucyl-tRNA aminoacylation
CFK40_07865	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CFK40_07890	COG2081	HI0933 family
CFK40_07895	COG2244	polysaccharide biosynthetic process
CFK40_07900	COG1187	pseudouridine synthase activity
CFK40_07905	COG1349	DNA-binding transcription factor activity
CFK40_07920	COG0510	thiamine kinase activity
CFK40_07930	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CFK40_07940	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CFK40_07945	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CFK40_07955	COG1309	transcriptional regulator
CFK40_07965	COG3773	Cell wall hydrolase
CFK40_07970	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
CFK40_07975	COG3285	dna ligase
CFK40_07975	COG1793	dna ligase
CFK40_07985	COG1363	Peptidase, m42
CFK40_07990	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
CFK40_08000	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CFK40_08005	COG4848	Belongs to the UPF0354 family
CFK40_08010	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CFK40_08015	COG1674	ftsk spoiiie
CFK40_08025	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CFK40_08035	COG4980	gas vesicle protein
CFK40_08045	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CFK40_08055	COG0123	including yeast histone deacetylase and acetoin utilization protein
CFK40_08060	COG0517	IMP dehydrogenase activity
CFK40_08065	COG0454	-acetyltransferase
CFK40_08070	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CFK40_08075	COG1268	BioY protein
CFK40_08080	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CFK40_08085	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CFK40_08090	COG2199	diguanylate cyclase activity
CFK40_08090	COG2203	Gaf domain
CFK40_08095	COG1956	GAF domain-containing protein
CFK40_08100	COG1309	transcriptional regulator
CFK40_08105	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
CFK40_08110	COG1104	cysteine desulfurase activity
CFK40_08115	COG0301	tRNA thio-modification
CFK40_08125	COG1574	metal-dependent hydrolase with the TIM-barrel fold
CFK40_08130	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CFK40_08140	COG3874	Sporulation protein YtfJ
CFK40_08145	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
CFK40_08150	COG0827	DNA restriction-modification system
CFK40_08155	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CFK40_08170	COG3279	Response regulator of the LytR AlgR family
CFK40_08190	COG0006	proline dipeptidase activity
CFK40_08200	COG1842	Phage shock protein A
CFK40_08210	COG3766	membrane
CFK40_08215	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CFK40_08220	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CFK40_08235	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
CFK40_08240	COG2814	Major facilitator Superfamily
CFK40_08250	COG4109	DRTGG domain
CFK40_08275	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
CFK40_08295	COG0587	DNA-directed DNA polymerase activity
CFK40_08300	COG0281	malic enzyme
CFK40_08305	COG2186	Transcriptional regulator
CFK40_08315	COG0825	malonyl-CoA metabolic process
CFK40_08320	COG0205	6-phosphofructokinase activity
CFK40_08330	COG3030	protein affecting phage T7 exclusion by the F plasmid
CFK40_08335	COG0628	permease
CFK40_08340	COG0372	Belongs to the citrate synthase family
CFK40_08345	COG0538	isocitrate dehydrogenase activity
CFK40_08350	COG0039	L-malate dehydrogenase activity
CFK40_08360	COG0745	RESPONSE REGULATOR receiver
CFK40_08365	COG5002	protein histidine kinase activity
CFK40_08370	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CFK40_08370	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CFK40_08375	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CFK40_08380	COG0237	dephospho-CoA kinase activity
CFK40_08385	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CFK40_08390	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
CFK40_08400	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CFK40_08405	COG3611	Membrane attachment protein
CFK40_08410	COG1484	DNA-dependent DNA replication
CFK40_08420	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CFK40_08425	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CFK40_08430	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CFK40_08435	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CFK40_08440	COG3326	Membrane
CFK40_08445	COG0398	Pfam SNARE associated Golgi protein
CFK40_08460	COG1363	Peptidase, m42
CFK40_08465	COG0741	lytic transglycosylase activity
CFK40_08470	COG1131	(ABC) transporter
CFK40_08495	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CFK40_08500	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CFK40_08505	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CFK40_08505	COG0072	phenylalanine-tRNA ligase activity
CFK40_08510	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CFK40_08515	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
CFK40_08520	COG1286	toxin biosynthetic process
CFK40_08525	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CFK40_08525	COG1796	DNA polymerase
CFK40_08530	COG1193	negative regulation of DNA recombination
CFK40_08535	COG3766	membrane
CFK40_08545	COG1309	transcriptional regulator
CFK40_08550	COG1024	Enoyl-CoA hydratase
CFK40_08555	COG2086	electron transfer activity
CFK40_08560	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CFK40_08565	COG3118	belongs to the thioredoxin family
CFK40_08570	COG0322	excinuclease ABC activity
CFK40_08575	COG1719	4-vinyl reductase, 4VR
CFK40_08580	COG2009	succinate dehydrogenase
CFK40_08585	COG1053	succinate dehydrogenase
CFK40_08590	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CFK40_08595	COG0824	Thioesterase
CFK40_08600	COG2197	response regulator
CFK40_08610	COG1335	isochorismatase
CFK40_08615	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CFK40_08620	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CFK40_08630	COG1846	Transcriptional regulator
CFK40_08635	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CFK40_08640	COG5401	PFAM Sporulation and spore germination
CFK40_08645	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
CFK40_08650	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CFK40_08655	COG0622	Phosphoesterase
CFK40_08675	COG0544	peptidyl-prolyl cis-trans isomerase activity
CFK40_08680	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CFK40_08690	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CFK40_08695	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CFK40_08715	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CFK40_08720	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CFK40_08725	COG0181	hydroxymethylbilane synthase activity
CFK40_08735	COG0113	porphobilinogen synthase activity
CFK40_08740	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CFK40_08745	COG1388	LysM domain
CFK40_08745	COG1388	LysM domain
CFK40_08760	COG0525	valine-tRNA ligase activity
CFK40_08770	COG0189	ligase activity
CFK40_08770	COG4067	protein conserved in archaea
CFK40_08775	COG0285	dihydrofolate synthase activity
CFK40_08780	COG0745	RESPONSE REGULATOR receiver
CFK40_08780	COG3706	GGDEF domain
CFK40_08790	COG2003	Belongs to the UPF0758 family
CFK40_08795	COG1077	Cell shape determining protein MreB Mrl
CFK40_08800	COG1792	Involved in formation and maintenance of cell shape
CFK40_08810	COG0850	regulation of cytokinetic process
CFK40_08815	COG2894	cell division
CFK40_08825	COG1994	Peptidase M50
CFK40_08830	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CFK40_08835	COG2868	ribosomal protein
CFK40_08840	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CFK40_08850	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CFK40_08855	COG1388	LysM domain
CFK40_08860	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CFK40_08870	COG0217	transcriptional regulatory protein
CFK40_08875	COG0632	four-way junction helicase activity
CFK40_08880	COG2255	four-way junction helicase activity
CFK40_08890	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CFK40_08895	COG0343	queuine tRNA-ribosyltransferase activity
CFK40_08900	COG1862	Preprotein translocase
CFK40_08910	COG2244	polysaccharide biosynthetic process
CFK40_08920	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CFK40_08920	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CFK40_08925	COG5416	Lipopolysaccharide assembly protein A domain
CFK40_08930	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CFK40_08930	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
CFK40_08935	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CFK40_08940	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CFK40_08945	COG1490	D-aminoacyl-tRNA deacylase activity
CFK40_08950	COG4991	sh3 domain protein
CFK40_08950	COG0860	N-Acetylmuramoyl-L-alanine amidase
CFK40_08950	COG3103	Sh3 type 3 domain protein
CFK40_08955	COG0124	histidyl-tRNA synthetase
CFK40_08960	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CFK40_08975	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CFK40_08980	COG1959	2 iron, 2 sulfur cluster binding
CFK40_08985	COG1104	cysteine desulfurase activity
CFK40_08990	COG0482	sulfurtransferase activity
CFK40_09000	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CFK40_09010	COG0628	permease
CFK40_09015	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CFK40_09020	COG4472	Bacterial protein of unknown function (DUF965)
CFK40_09025	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CFK40_09030	COG3906	Belongs to the UPF0473 family
CFK40_09035	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CFK40_09045	COG0572	uridine kinase
CFK40_09050	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CFK40_09060	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CFK40_09070	COG1191	sigma factor activity
CFK40_09080	COG2212	antiporter activity
CFK40_09090	COG0651	ATP synthesis coupled electron transport
CFK40_09095	COG1006	Multisubunit Na H antiporter MnhC subunit
CFK40_09100	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CFK40_09100	COG2111	Na H antiporter
CFK40_09110	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
CFK40_09115	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
CFK40_09120	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CFK40_09125	COG1534	Rna-binding protein
CFK40_09130	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CFK40_09135	COG1713	HD superfamily hydrolase involved in NAD metabolism
CFK40_09140	COG0799	negative regulation of ribosome biogenesis
CFK40_09145	COG2226	methyltransferase
CFK40_09150	COG1555	photosystem II stabilization
CFK40_09150	COG1596	polysaccharide export
CFK40_09155	COG2131	deaminase
CFK40_09160	COG2333	competence protein COMEC
CFK40_09160	COG0658	competence protein
CFK40_09170	COG1466	dna polymerase III delta subunit
CFK40_09175	COG0268	Binds directly to 16S ribosomal RNA
CFK40_09180	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
CFK40_09185	COG0860	N-Acetylmuramoyl-L-alanine amidase
CFK40_09195	COG0481	GTPase activity
CFK40_09200	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CFK40_09205	COG1420	regulation of RNA biosynthetic process
CFK40_09210	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CFK40_09215	COG0443	Heat shock 70 kDa protein
CFK40_09220	COG0484	heat shock protein binding
CFK40_09225	COG2264	protein methyltransferase activity
CFK40_09230	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CFK40_09235	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CFK40_09240	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CFK40_09245	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CFK40_09250	COG1610	YqeY-like protein
CFK40_09255	COG1030	water channel activity
CFK40_09260	COG4864	UPF0365 protein
CFK40_09280	COG1702	phosphate starvation-inducible protein PhoH
CFK40_09285	COG1480	7TM receptor with intracellular HD hydrolase
CFK40_09290	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CFK40_09300	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CFK40_09310	COG1381	Involved in DNA repair and RecF pathway recombination
CFK40_09315	COG0752	glycyl-tRNA synthetase alpha subunit
CFK40_09320	COG0751	glycine-tRNA ligase activity
CFK40_09325	COG0517	IMP dehydrogenase activity
CFK40_09330	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
CFK40_09335	COG0358	DNA primase activity
CFK40_09340	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CFK40_09350	COG2384	SAM-dependent methyltransferase
CFK40_09355	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CFK40_09360	COG0513	Belongs to the DEAD box helicase family
CFK40_09365	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
CFK40_09375	COG0640	Transcriptional regulator
CFK40_09380	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CFK40_09385	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CFK40_09390	COG4709	membrane
CFK40_09405	COG0704	Plays a role in the regulation of phosphate uptake
CFK40_09440	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CFK40_09445	COG0477	Major facilitator Superfamily
CFK40_09455	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CFK40_09460	COG0573	inorganic phosphate transmembrane transporter activity
CFK40_09465	COG0581	inorganic phosphate transmembrane transporter activity
CFK40_09470	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CFK40_09475	COG0704	Plays a role in the regulation of phosphate uptake
CFK40_09480	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CFK40_09490	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CFK40_09495	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CFK40_09500	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CFK40_09510	COG0457	Tetratricopeptide repeat
CFK40_09510	COG0705	Rhomboid family
CFK40_09520	COG0697	spore germination
CFK40_09530	COG1940	carbohydrate kinase activity
CFK40_09535	COG1368	sulfuric ester hydrolase activity
CFK40_09545	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CFK40_09575	COG4537	Required for transformation and DNA binding
CFK40_09580	COG1459	type II secretion system
CFK40_09585	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CFK40_09605	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CFK40_09610	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CFK40_09615	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CFK40_09620	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CFK40_09630	COG1396	sequence-specific DNA binding
CFK40_09640	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
CFK40_09650	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
CFK40_09670	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CFK40_09715	COG1321	iron dependent repressor
CFK40_09720	COG1752	Esterase of the alpha-beta hydrolase superfamily
CFK40_09735	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CFK40_09740	COG0006	proline dipeptidase activity
CFK40_09745	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CFK40_09760	COG3854	ATPases associated with a variety of cellular activities
CFK40_09800	COG0511	ligase activity, forming carbon-carbon bonds
CFK40_09805	COG0439	Biotin carboxylase
CFK40_09810	COG1302	Protein conserved in bacteria
CFK40_09815	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CFK40_09820	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CFK40_09825	COG1570	exodeoxyribonuclease VII activity
CFK40_09830	COG1722	exodeoxyribonuclease VII activity
CFK40_09845	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
CFK40_09850	COG1438	arginine binding
CFK40_09855	COG0497	DNA recombination
CFK40_09860	COG0750	zinc metalloprotease
CFK40_09865	COG0745	RESPONSE REGULATOR receiver
CFK40_09990	COG3829	transcription factor binding
CFK40_09990	COG3290	protein histidine kinase activity
CFK40_09995	COG0280	phosphate acetyltransferase
CFK40_10005	COG3426	butyrate kinase activity
CFK40_10010	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CFK40_10015	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CFK40_10020	COG0022	dehydrogenase e1 component
CFK40_10025	COG0508	dehydrogenase complex catalyzes the overall conversion of
CFK40_10035	COG4129	membrane
CFK40_10045	COG0346	lactoylglutathione lyase activity
CFK40_10050	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CFK40_10055	COG2195	Cleaves the N-terminal amino acid of tripeptides
CFK40_10060	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CFK40_10065	COG1309	transcriptional regulator
CFK40_10070	COG4166	transmembrane transport
CFK40_10095	COG2814	Major facilitator Superfamily
CFK40_10110	COG1694	Mazg nucleotide pyrophosphohydrolase
CFK40_10150	COG0492	ferredoxin-NADP+ reductase activity
CFK40_10160	COG1012	belongs to the aldehyde dehydrogenase family
CFK40_10165	COG1234	tRNA 3'-trailer cleavage
CFK40_10170	COG1902	pentaerythritol trinitrate reductase activity
CFK40_10175	COG0584	glycerophosphoryl diester phosphodiesterase
CFK40_10180	COG4187	Peptidase family M20/M25/M40
CFK40_10185	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CFK40_10190	COG0300	oxidoreductase activity
CFK40_10205	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CFK40_10210	COG1012	belongs to the aldehyde dehydrogenase family
CFK40_10250	COG4948	Mandelate Racemase Muconate Lactonizing
CFK40_10255	COG3949	Membrane
CFK40_10265	COG2226	methyltransferase
CFK40_10355	COG1953	Uracil, thiamine, allantoin
CFK40_10385	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CFK40_10390	COG0006	proline dipeptidase activity
CFK40_10395	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CFK40_10420	COG0546	phosphoglycolate phosphatase activity
CFK40_10425	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
CFK40_10435	COG3540	Alkaline phosphatase
CFK40_10460	COG1595	DNA-templated transcription, initiation
CFK40_10470	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CFK40_10475	COG0697	spore germination
CFK40_10490	COG0456	acetyltransferase
CFK40_10490	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
CFK40_10500	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
CFK40_10505	COG2169	Transcriptional regulator
CFK40_10510	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CFK40_10515	COG2329	Antibiotic biosynthesis monooxygenase
CFK40_10520	COG0456	acetyltransferase
CFK40_10570	COG0583	DNA-binding transcription factor activity
CFK40_10590	COG0626	cystathionine gamma-synthase activity
CFK40_10595	COG2808	Putative FMN-binding domain
CFK40_10600	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CFK40_10630	COG0671	phosphoesterase, PA-phosphatase related
CFK40_10635	COG1119	ATPase activity
CFK40_10645	COG2226	methyltransferase
CFK40_10650	COG0588	phosphoglycerate mutase activity
CFK40_10670	COG1902	pentaerythritol trinitrate reductase activity
CFK40_10725	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CFK40_10730	COG0667	Aldo Keto reductase
CFK40_10740	COG1379	DNA repair
CFK40_10745	COG1300	Membrane
CFK40_10750	COG0735	belongs to the Fur family
CFK40_10765	COG4974	Belongs to the 'phage' integrase family
CFK40_10770	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
CFK40_10785	COG1686	Belongs to the peptidase S11 family
CFK40_10790	COG1366	Belongs to the anti-sigma-factor antagonist family
CFK40_10795	COG2172	sigma factor antagonist activity
CFK40_10815	COG0697	spore germination
CFK40_10820	COG0019	diaminopimelate decarboxylase activity
CFK40_10825	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CFK40_10830	COG0456	acetyltransferase
CFK40_10840	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
CFK40_10845	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CFK40_10850	COG1686	Belongs to the peptidase S11 family
CFK40_10855	COG2715	membrane protein required for spore maturation
CFK40_10860	COG0700	Nucleoside recognition
CFK40_10865	COG1187	pseudouridine synthase activity
CFK40_10870	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CFK40_10875	COG1333	cytochrome c biogenesis protein
CFK40_10880	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CFK40_10885	COG0745	RESPONSE REGULATOR receiver
CFK40_10890	COG5002	protein histidine kinase activity
CFK40_10905	COG1141	Ferredoxin
CFK40_10910	COG4955	Helix-turn-helix domain
CFK40_10915	COG0514	ATP-dependent DNA helicase (RecQ)
CFK40_10920	COG1266	CAAX protease self-immunity
CFK40_10930	COG3546	catalase activity
CFK40_10945	COG1408	metallophosphoesterase
CFK40_10950	COG4862	establishment of competence for transformation
CFK40_10955	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CFK40_10960	COG0492	ferredoxin-NADP+ reductase activity
CFK40_10970	COG2339	peptidase activity
CFK40_10975	COG3773	Cell wall hydrolase
CFK40_10975	COG3409	Peptidoglycan-binding domain 1 protein
CFK40_10980	COG2959	enzyme of heme biosynthesis
CFK40_10995	COG0539	negative regulation of cytoplasmic translation
CFK40_11005	COG1160	GTP binding
CFK40_11010	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CFK40_11030	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
CFK40_11035	COG0776	regulation of translation
CFK40_11045	COG0142	geranyltranstransferase activity
CFK40_11050	COG2226	methyltransferase
CFK40_11055	COG0142	geranyltranstransferase activity
CFK40_11060	COG0105	UTP biosynthetic process
CFK40_11065	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CFK40_11070	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CFK40_11075	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CFK40_11080	COG0457	Tetratricopeptide repeat
CFK40_11085	COG5582	Belongs to the UPF0302 family
CFK40_11100	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CFK40_11110	COG4347	Protein of unknown function (DUF1405)
CFK40_11120	COG2738	Putative neutral zinc metallopeptidase
CFK40_11125	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CFK40_11130	COG1694	Mazg nucleotide pyrophosphohydrolase
CFK40_11135	COG1803	Methylglyoxal synthase
CFK40_11140	COG0438	transferase activity, transferring glycosyl groups
CFK40_11145	COG0617	tRNA 3'-terminal CCA addition
CFK40_11160	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CFK40_11165	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
CFK40_11170	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CFK40_11170	COG1199	ATP-dependent helicase activity
CFK40_11185	COG0436	Aminotransferase
CFK40_11190	COG0017	Asparaginyl-tRNA synthetase
CFK40_11195	COG3935	DnaD domain protein
CFK40_11200	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CFK40_11205	COG4499	WXG100 protein secretion system (Wss), protein YukC
CFK40_11205	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CFK40_11210	COG3331	DNA recombination
CFK40_11230	COG0295	cytidine deaminase activity
CFK40_11235	COG3599	regulation of cell shape
CFK40_11245	COG0116	Belongs to the methyltransferase superfamily
CFK40_11250	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
CFK40_11255	COG3424	synthase
CFK40_11260	COG1755	Isoprenylcysteine carboxyl methyltransferase
CFK40_11290	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
CFK40_11295	COG1278	Cold shock
CFK40_11305	COG1418	mRNA catabolic process
CFK40_11310	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
CFK40_11315	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CFK40_11320	COG0746	molybdenum cofactor guanylyltransferase activity
CFK40_11325	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CFK40_11330	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CFK40_11335	COG0805	protein transport
CFK40_11340	COG4479	Belongs to the UPF0346 family
CFK40_11345	COG0420	3'-5' exonuclease activity
CFK40_11350	COG0419	ATPase involved in DNA repair
CFK40_11360	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CFK40_11360	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CFK40_11390	COG3191	aminopeptidase activity
CFK40_11395	COG0723	plastoquinol--plastocyanin reductase activity
CFK40_11395	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CFK40_11400	COG0583	DNA-binding transcription factor activity
CFK40_11405	COG0372	Belongs to the citrate synthase family
CFK40_11415	COG0785	Cytochrome C biogenesis protein
CFK40_11430	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CFK40_11435	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
CFK40_11450	COG1418	mRNA catabolic process
CFK40_11455	COG2814	Major facilitator Superfamily
CFK40_11460	COG1378	Sugar-specific transcriptional regulator TrmB
CFK40_11465	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
CFK40_11470	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CFK40_11475	COG2323	membrane
CFK40_11490	COG0390	transport system, permease component
CFK40_11505	COG1063	alcohol dehydrogenase
CFK40_11510	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CFK40_11515	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
CFK40_11520	COG0516	GMP reductase activity
CFK40_11520	COG0517	IMP dehydrogenase activity
CFK40_11530	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CFK40_11535	COG1024	Enoyl-CoA hydratase
CFK40_11540	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CFK40_11545	COG0511	ligase activity, forming carbon-carbon bonds
CFK40_11550	COG0439	Biotin carboxylase
CFK40_11555	COG0318	PFAM AMP-dependent synthetase and ligase
CFK40_11560	COG1960	acyl-CoA dehydrogenase activity
CFK40_11565	COG1309	transcriptional regulator
CFK40_11570	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CFK40_11575	COG0187	DNA topoisomerase II activity
CFK40_11580	COG1832	CoA-binding protein
CFK40_11585	COG1174	glycine betaine transport
CFK40_11595	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CFK40_11600	COG1469	GTP cyclohydrolase I activity
CFK40_11605	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CFK40_11615	COG0824	Thioesterase
CFK40_11625	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CFK40_11635	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CFK40_11640	COG4191	Histidine kinase
CFK40_11650	COG4846	Membrane protein involved in cytochrome C biogenesis
CFK40_11655	COG2111	Na H antiporter
CFK40_11660	COG0785	Cytochrome C biogenesis protein
CFK40_11665	COG3763	UPF0154 protein
CFK40_11675	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CFK40_11680	COG4224	UPF0291 protein
CFK40_11685	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CFK40_11690	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CFK40_11705	COG2318	DinB family
CFK40_11710	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CFK40_11725	COG2318	DinB family
CFK40_11730	COG0860	N-Acetylmuramoyl-L-alanine amidase
CFK40_11755	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CFK40_11775	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
CFK40_11780	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CFK40_11820	COG1940	carbohydrate kinase activity
CFK40_11845	COG4974	Belongs to the 'phage' integrase family
CFK40_11850	COG0174	glutamine synthetase
CFK40_11855	COG0789	Transcriptional regulator
CFK40_11860	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
CFK40_11870	COG0464	growth
CFK40_11875	COG1923	regulation of RNA biosynthetic process
CFK40_11880	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CFK40_11885	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CFK40_11890	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CFK40_11900	COG4550	Control of competence regulator ComK, YlbF/YmcA
CFK40_11905	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CFK40_11910	COG2359	stage V sporulation protein S
CFK40_11915	COG1692	metallophosphoesterase
CFK40_11920	COG1418	mRNA catabolic process
CFK40_11925	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CFK40_11930	COG1058	Belongs to the CinA family
CFK40_11930	COG1546	Belongs to the CinA family
CFK40_11935	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CFK40_11940	COG1426	Protein conserved in bacteria
CFK40_11955	COG0300	oxidoreductase activity
CFK40_11960	COG0612	Peptidase, M16
CFK40_11965	COG0612	Peptidase, M16
CFK40_11990	COG2188	Transcriptional regulator
CFK40_11995	COG1674	ftsk spoiiie
CFK40_12005	COG0740	serine-type endopeptidase activity
CFK40_12015	COG0527	aspartate kinase activity
CFK40_12020	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CFK40_12025	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CFK40_12030	COG1873	PFAM PRC-barrel domain
CFK40_12035	COG0612	Peptidase, M16
CFK40_12040	COG0726	polysaccharide deacetylase
CFK40_12045	COG1185	polyribonucleotide nucleotidyltransferase activity
CFK40_12050	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CFK40_12055	COG0196	riboflavin kinase activity
CFK40_12060	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CFK40_12065	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CFK40_12070	COG1550	Protein conserved in bacteria
CFK40_12075	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CFK40_12085	COG2740	Nucleic-acid-binding protein implicated in transcription termination
CFK40_12090	COG0195	Participates in both transcription termination and antitermination
CFK40_12095	COG0779	Required for maturation of 30S ribosomal subunits
CFK40_12100	COG2176	DNA-directed DNA polymerase activity
CFK40_12105	COG0750	zinc metalloprotease
CFK40_12110	COG4589	Belongs to the CDS family
CFK40_12115	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CFK40_12120	COG0233	cytoplasmic translational termination
CFK40_12125	COG0528	UMP kinase activity
CFK40_12130	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CFK40_12135	COG0052	Belongs to the universal ribosomal protein uS2 family
CFK40_12145	COG1191	sigma factor activity
CFK40_12155	COG2198	Histidine kinase
CFK40_12155	COG0643	Histidine kinase
CFK40_12160	COG0455	bacterial-type flagellum organization
CFK40_12165	COG1419	protein localization to endoplasmic reticulum
CFK40_12170	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CFK40_12175	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CFK40_12180	COG1684	flagellar biosynthetic protein fliR
CFK40_12185	COG1987	bacterial-type flagellum assembly
CFK40_12190	COG1338	Plays a role in the flagellum-specific transport system
CFK40_12195	COG3190	flagellar
CFK40_12200	COG2201	protein-glutamate methylesterase activity
CFK40_12205	COG1776	CheC inhibitor of MCP methylation
CFK40_12205	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CFK40_12210	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CFK40_12215	COG1580	Controls the rotational direction of flagella during chemotaxis
CFK40_12220	COG1582	Flagellar protein (FlbD)
CFK40_12225	COG4786	Flagellar basal body rod
CFK40_12235	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
CFK40_12255	COG1157	protein secretion by the type III secretion system
CFK40_12260	COG1317	bacterial-type flagellum organization
CFK40_12265	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CFK40_12270	COG1766	The M ring may be actively involved in energy transduction
CFK40_12275	COG1677	Flagellar hook-basal body complex protein FliE
CFK40_12280	COG1558	bacterial-type flagellum-dependent cell motility
CFK40_12285	COG1815	bacterial-type flagellum-dependent cell motility
CFK40_12290	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
CFK40_12295	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
CFK40_12300	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
CFK40_12305	COG4974	Belongs to the 'phage' integrase family
CFK40_12315	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CFK40_12320	COG0758	DNA mediated transformation
CFK40_12325	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CFK40_12330	COG0045	succinate-CoA ligase (ADP-forming) activity
CFK40_12335	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CFK40_12345	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CFK40_12360	COG0335	large ribosomal subunit rRNA binding
CFK40_12365	COG0336	Belongs to the RNA methyltransferase TrmD family
CFK40_12370	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CFK40_12380	COG1837	Belongs to the UPF0109 family
CFK40_12385	COG0228	four-way junction DNA binding
CFK40_12390	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CFK40_12395	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
CFK40_12400	COG0552	protein localization to endoplasmic reticulum
CFK40_12405	COG1196	nuclear chromosome segregation
CFK40_12415	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CFK40_12445	COG0076	glutamate decarboxylase activity
CFK40_12455	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
CFK40_12475	COG0697	spore germination
CFK40_12490	COG3949	Membrane
CFK40_12500	COG1063	alcohol dehydrogenase
CFK40_12510	COG4840	Belongs to the UPF0435 family
CFK40_12515	COG0571	ribonuclease III activity
CFK40_12520	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CFK40_12525	COG1028	Short-chain dehydrogenase reductase Sdr
CFK40_12530	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CFK40_12535	COG0416	fatty acid biosynthetic process
CFK40_12540	COG1349	DNA-binding transcription factor activity
CFK40_12545	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CFK40_12550	COG1760	l-serine dehydratase
CFK40_12555	COG1760	l-serine dehydratase
CFK40_12560	COG1028	Short-chain dehydrogenase reductase Sdr
CFK40_12615	COG0730	response to heat
CFK40_12620	COG0583	DNA-binding transcription factor activity
CFK40_12630	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
CFK40_12635	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CFK40_12640	COG0431	NADPH-dependent FMN reductase
CFK40_12650	COG1733	regulation of RNA biosynthetic process
CFK40_12655	COG0753	catalase activity
CFK40_12675	COG3584	3D domain protein
CFK40_12675	COG1388	LysM domain
CFK40_12680	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CFK40_12685	COG3588	fructose-bisphosphate aldolase
CFK40_12695	COG1607	acyl-coa hydrolase
CFK40_12700	COG1461	Dihydroxyacetone kinase
CFK40_12705	COG1302	Protein conserved in bacteria
CFK40_12710	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CFK40_12720	COG1564	THIamine pyrophosphokinase
CFK40_12725	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CFK40_12730	COG1162	GTPase activity
CFK40_12735	COG0515	serine threonine protein kinase
CFK40_12735	COG2815	serine threonine protein kinase
CFK40_12740	COG0631	protein serine/threonine phosphatase activity
CFK40_12745	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CFK40_12745	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CFK40_12750	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CFK40_12755	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CFK40_12760	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CFK40_12765	COG1758	RNA polymerase activity
CFK40_12770	COG2052	Domain of unknown function (DUF370)
CFK40_12775	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CFK40_12785	COG1764	response to oxidative stress
CFK40_12790	COG0583	DNA-binding transcription factor activity
CFK40_12795	COG2226	methyltransferase
CFK40_12800	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CFK40_12805	COG0284	orotidine-5'-phosphate decarboxylase activity
CFK40_12810	COG0167	dihydroorotate dehydrogenase activity
CFK40_12815	COG0543	2 iron, 2 sulfur cluster binding
CFK40_12820	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CFK40_12825	COG0505	Belongs to the CarA family
CFK40_12830	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CFK40_12835	COG0540	Belongs to the ATCase OTCase family
CFK40_12840	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
CFK40_12845	COG0564	pseudouridine synthase activity
CFK40_12850	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CFK40_12855	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CFK40_12860	COG3599	regulation of cell shape
CFK40_12865	COG2302	S4 RNA-binding domain
CFK40_12870	COG0762	integral membrane protein
CFK40_12875	COG1799	cell septum assembly
CFK40_12880	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CFK40_12890	COG1873	PFAM PRC-barrel domain
CFK40_12895	COG1191	sigma factor activity
CFK40_12900	COG1191	sigma factor activity
CFK40_12910	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CFK40_12915	COG0849	cell division
CFK40_12920	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CFK40_12925	COG0772	Belongs to the SEDS family
CFK40_12930	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CFK40_12935	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CFK40_12940	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CFK40_12945	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CFK40_12950	COG0768	penicillin binding
CFK40_12960	COG4839	cell division protein FtsL
CFK40_12965	COG0275	rRNA processing
CFK40_12970	COG2001	Belongs to the MraZ family
CFK40_12975	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
CFK40_12985	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CFK40_12990	COG0454	-acetyltransferase
CFK40_13000	COG1024	Enoyl-CoA hydratase
CFK40_13005	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CFK40_13010	COG1399	metal-binding, possibly nucleic acid-binding protein
CFK40_13015	COG1323	Belongs to the UPF0348 family
CFK40_13020	COG3480	Lon protease (S16) C-terminal proteolytic domain
CFK40_13025	COG3314	Sporulation integral membrane protein YlbJ
CFK40_13030	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CFK40_13035	COG0742	ribosomal rna small subunit methyltransferase
CFK40_13040	COG4471	UPF0298 protein
CFK40_13045	COG3679	Belongs to the UPF0342 family
CFK40_13060	COG2340	Cysteine-rich secretory protein family
CFK40_13075	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CFK40_13085	COG2322	membrane
CFK40_13090	COG3336	cytochrome c oxidase
CFK40_13100	COG1845	cytochrome c oxidase, subunit III
CFK40_13110	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CFK40_13110	COG2010	Cytochrome c
CFK40_13115	COG0109	protoheme IX farnesyltransferase activity
CFK40_13120	COG1612	heme a metabolic process
CFK40_13125	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
CFK40_13130	COG0772	Belongs to the SEDS family
CFK40_13135	COG4838	Belongs to the UPF0358 family
CFK40_13140	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CFK40_13155	COG4896	Protein conserved in bacteria
CFK40_13165	COG0483	inositol monophosphate 1-phosphatase activity
CFK40_13175	COG4493	Belongs to the UPF0637 family
CFK40_13180	COG4476	Belongs to the UPF0223 family
CFK40_13190	COG1982	Orn Lys Arg decarboxylase major
CFK40_13200	COG0726	polysaccharide deacetylase
CFK40_13205	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CFK40_13220	COG0022	dehydrogenase e1 component
CFK40_13235	COG0242	peptide deformylase activity
CFK40_13245	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CFK40_13250	COG0028	Belongs to the TPP enzyme family
CFK40_13255	COG0569	domain protein
CFK40_13260	COG1294	oxidase, subunit
CFK40_13265	COG1132	(ABC) transporter
CFK40_13270	COG1132	(ABC) transporter
CFK40_13275	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CFK40_13280	COG0450	alkyl hydroperoxide reductase
CFK40_13285	COG0668	transmembrane transport
CFK40_13295	COG0477	Major facilitator Superfamily
CFK40_13300	COG0517	IMP dehydrogenase activity
CFK40_13305	COG1408	metallophosphoesterase
CFK40_13310	COG1999	signal sequence binding
CFK40_13350	COG0681	Belongs to the peptidase S26 family
CFK40_13360	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CFK40_13370	COG3300	MHYT domain
CFK40_13370	COG5001	Diguanylate cyclase
CFK40_13375	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CFK40_13385	COG0303	'Molybdopterin
CFK40_13410	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CFK40_13425	COG2323	membrane
CFK40_13430	COG1525	nuclease
CFK40_13435	COG0697	spore germination
CFK40_13450	COG0604	alcohol dehydrogenase
CFK40_13455	COG0003	Pfam Anion-transporting ATPase
CFK40_13465	COG1966	Carbon starvation protein
CFK40_13470	COG2427	Protein of unknown function (DUF1641)
CFK40_13475	COG3383	formate dehydrogenase (NAD+) activity
CFK40_13480	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CFK40_13485	COG3069	C4-dicarboxylate transmembrane transporter activity
CFK40_13490	COG3859	Proton-coupled thiamine transporter YuaJ
CFK40_13505	COG4637	Psort location Cytoplasmic, score
CFK40_13510	COG2353	YceI-like domain
CFK40_13545	COG1252	NADH dehydrogenase
CFK40_13565	COG0318	PFAM AMP-dependent synthetase and ligase
CFK40_13595	COG1408	metallophosphoesterase
CFK40_13605	COG1132	(ABC) transporter
CFK40_13635	COG1216	Glycosyl transferase, family 2
CFK40_13640	COG1132	(ABC) transporter
CFK40_13660	COG0438	transferase activity, transferring glycosyl groups
CFK40_13670	COG1216	Glycosyl transferase, family 2
CFK40_13670	COG1442	glycosyl transferase family 8
CFK40_13680	COG0438	transferase activity, transferring glycosyl groups
CFK40_13685	COG1396	sequence-specific DNA binding
CFK40_13690	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CFK40_13695	COG0110	maltose O-acetyltransferase activity
CFK40_13700	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CFK40_13705	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CFK40_13715	COG0463	Glycosyl transferase, family 2
CFK40_13715	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
CFK40_13720	COG0438	transferase activity, transferring glycosyl groups
CFK40_13725	COG0438	transferase activity, transferring glycosyl groups
CFK40_13730	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CFK40_13740	COG0489	protein tyrosine kinase activity
CFK40_13745	COG3944	biosynthesis protein
CFK40_13750	COG0513	Belongs to the DEAD box helicase family
CFK40_13760	COG1231	oxidoreductase activity
CFK40_13785	COG0077	Prephenate dehydratase
CFK40_13795	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CFK40_13815	COG2027	D-alanyl-D-alanine carboxypeptidase
CFK40_13850	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CFK40_13855	COG0066	3-isopropylmalate dehydratase activity
CFK40_13860	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CFK40_13865	COG0473	3-isopropylmalate dehydrogenase activity
CFK40_13870	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CFK40_13875	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CFK40_13880	COG0440	acetolactate synthase activity
CFK40_13885	COG0028	Belongs to the TPP enzyme family
CFK40_13890	COG0083	homoserine kinase activity
CFK40_13895	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CFK40_13900	COG0460	homoserine dehydrogenase
CFK40_13905	COG0527	aspartate kinase activity
CFK40_13910	COG0129	dihydroxy-acid dehydratase activity
CFK40_13915	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CFK40_13920	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CFK40_13930	COG1966	Carbon starvation protein
CFK40_13935	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CFK40_13940	COG1585	Membrane protein implicated in regulation of membrane protease activity
CFK40_13945	COG2268	Band 7 protein
CFK40_13965	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
CFK40_13970	COG4988	ABC transporter
CFK40_13975	COG1271	oxidase subunit
CFK40_14030	COG2515	1-aminocyclopropane-1-carboxylate deaminase
CFK40_14050	COG1228	amidohydrolase
CFK40_14060	COG0287	Prephenate dehydrogenase
CFK40_14065	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CFK40_14070	COG1605	Chorismate mutase
CFK40_14070	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
CFK40_14075	COG0436	Aminotransferase
CFK40_14080	COG0527	aspartate kinase activity
CFK40_14085	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CFK40_14090	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CFK40_14095	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CFK40_14120	COG1473	amidohydrolase
CFK40_14125	COG1012	belongs to the aldehyde dehydrogenase family
CFK40_14160	COG5444	nuclease activity
CFK40_14180	COG1511	domain protein
CFK40_14185	COG1674	ftsk spoiiie
CFK40_14190	COG4499	WXG100 protein secretion system (Wss), protein YukC
CFK40_14195	COG5417	Belongs to the EsaB family
CFK40_14200	COG4842	Belongs to the WXG100 family
CFK40_14250	COG0493	'glutamate synthase
CFK40_14255	COG0069	glutamate synthase activity
CFK40_14255	COG0067	glutamate synthase
CFK40_14255	COG0070	glutamate synthase
CFK40_14260	COG0583	DNA-binding transcription factor activity
CFK40_14270	COG0431	NADPH-dependent FMN reductase
CFK40_14275	COG0385	Bile acid
CFK40_14280	COG3192	ethanolamine utilization protein
CFK40_14285	COG0006	proline dipeptidase activity
CFK40_14300	COG1454	alcohol dehydrogenase
CFK40_14305	COG2188	Transcriptional regulator
CFK40_14315	COG1024	Enoyl-CoA hydratase
CFK40_14345	COG0183	Belongs to the thiolase family
CFK40_14350	COG0318	PFAM AMP-dependent synthetase and ligase
CFK40_14355	COG2271	Major facilitator Superfamily
CFK40_14360	COG1960	acyl-CoA dehydrogenase activity
CFK40_14370	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CFK40_14375	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CFK40_14420	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
CFK40_14430	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CFK40_14435	COG2610	gluconate transmembrane transporter activity
CFK40_14440	COG4948	Mandelate Racemase Muconate Lactonizing
CFK40_14445	COG0800	Aldolase
CFK40_14450	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CFK40_14455	COG1737	Transcriptional regulator
CFK40_14460	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
CFK40_14465	COG1070	Carbohydrate kinase
CFK40_14470	COG2610	gluconate transmembrane transporter activity
CFK40_14475	COG1028	Short-chain dehydrogenase reductase Sdr
CFK40_14485	COG0583	DNA-binding transcription factor activity
CFK40_14495	COG1414	Transcriptional regulator
CFK40_14510	COG0833	amino acid
CFK40_14515	COG4187	Peptidase family M20/M25/M40
CFK40_14530	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
CFK40_14535	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CFK40_14540	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CFK40_14545	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
CFK40_14560	COG1012	belongs to the aldehyde dehydrogenase family
CFK40_14565	COG1960	acyl-CoA dehydrogenase activity
CFK40_14570	COG1960	acyl-CoA dehydrogenase activity
CFK40_14590	COG2030	dehydratase
CFK40_14595	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CFK40_14595	COG1042	CoA-binding domain protein
CFK40_14595	COG0045	succinate-CoA ligase (ADP-forming) activity
CFK40_14630	COG1357	PFAM Pentapeptide repeats (8 copies)
CFK40_14660	COG0516	GMP reductase activity
CFK40_14680	COG1757	Na H antiporter
CFK40_14690	COG1012	belongs to the aldehyde dehydrogenase family
CFK40_14695	COG0028	Belongs to the TPP enzyme family
CFK40_14700	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
CFK40_14700	COG0456	acetyltransferase
CFK40_14720	COG2056	Na+-H+ antiporter family
CFK40_14725	COG2986	histidine ammonia-lyase
CFK40_14735	COG2195	Cleaves the N-terminal amino acid of tripeptides
CFK40_14740	COG1228	amidohydrolase
CFK40_14745	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
CFK40_14750	COG0583	DNA-binding transcription factor activity
CFK40_14755	COG0622	Phosphoesterase
CFK40_14765	COG0714	Associated with various cellular activities
CFK40_14775	COG4548	von Willebrand factor, type A
CFK40_14780	COG0281	malic enzyme
CFK40_14785	COG1027	Aspartate ammonia-lyase
CFK40_14790	COG2843	Capsule synthesis protein
CFK40_14795	COG0778	Nitroreductase
CFK40_14805	COG0167	dihydroorotate dehydrogenase activity
CFK40_14810	COG0543	2 iron, 2 sulfur cluster binding
CFK40_14815	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CFK40_14820	COG2508	Transcriptional regulator
CFK40_14825	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CFK40_14830	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CFK40_14850	COG0791	NLP P60 protein
CFK40_14850	COG1388	LysM domain
CFK40_14860	COG0402	S-adenosylhomocysteine deaminase activity
CFK40_14865	COG0402	S-adenosylhomocysteine deaminase activity
CFK40_14870	COG0747	negative chemotaxis
CFK40_14880	COG0601	transmembrane transport
CFK40_14885	COG0444	Belongs to the ABC transporter superfamily
CFK40_14890	COG4608	Belongs to the ABC transporter superfamily
CFK40_14895	COG3275	phosphorelay sensor kinase activity
CFK40_14910	COG3153	acetyltransferase
CFK40_14910	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CFK40_14915	COG1012	belongs to the aldehyde dehydrogenase family
CFK40_14930	COG3829	transcription factor binding
CFK40_14930	COG3290	protein histidine kinase activity
CFK40_14935	COG0531	amino acid
CFK40_14945	COG0531	amino acid
CFK40_14950	COG0531	amino acid
CFK40_14955	COG2957	Belongs to the agmatine deiminase family
CFK40_14960	COG1012	belongs to the aldehyde dehydrogenase family
CFK40_14965	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CFK40_14980	COG2957	Belongs to the agmatine deiminase family
CFK40_14985	COG1012	belongs to the aldehyde dehydrogenase family
CFK40_14990	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CFK40_14995	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CFK40_15000	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CFK40_15005	COG0183	Belongs to the thiolase family
CFK40_15010	COG1960	acyl-CoA dehydrogenase activity
CFK40_15020	COG1309	transcriptional regulator
CFK40_15025	COG3119	arylsulfatase activity
CFK40_15030	COG1262	PFAM Formylglycine-generating sulfatase enzyme
CFK40_15035	COG3459	Glycosyltransferase 36 associated
CFK40_15050	COG1175	transmembrane transport
CFK40_15055	COG0395	ABC-type sugar transport system, permease component
CFK40_15065	COG1609	Transcriptional regulator
CFK40_15100	COG3655	Transcriptional regulator
CFK40_15110	COG2252	PERMEase
CFK40_15140	COG3425	synthase
CFK40_15145	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CFK40_15170	COG1312	Catalyzes the dehydration of D-mannonate
CFK40_15175	COG1012	belongs to the aldehyde dehydrogenase family
CFK40_15180	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CFK40_15185	COG2186	Transcriptional regulator
CFK40_15210	COG0786	glutamate:sodium symporter activity
CFK40_15215	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CFK40_15235	COG0473	3-isopropylmalate dehydrogenase activity
CFK40_15250	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CFK40_15255	COG2186	Transcriptional regulator
CFK40_15265	COG2322	membrane
CFK40_15280	COG3250	beta-galactosidase activity
CFK40_15290	COG1595	DNA-templated transcription, initiation
CFK40_15305	COG1653	transport
CFK40_15310	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CFK40_15315	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CFK40_15320	COG1028	Short-chain dehydrogenase reductase Sdr
CFK40_15340	COG0789	Transcriptional regulator
CFK40_15345	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
CFK40_15400	COG0456	acetyltransferase
CFK40_15400	COG0454	-acetyltransferase
CFK40_15405	COG2304	oxidoreductase activity
CFK40_15425	COG1732	Glycine betaine
CFK40_15430	COG1174	glycine betaine transport
CFK40_15435	COG1125	glycine betaine transport
CFK40_15435	COG0517	IMP dehydrogenase activity
CFK40_15440	COG0305	Participates in initiation and elongation during chromosome replication
CFK40_15450	COG3935	DnaD domain protein
CFK40_15480	COG1122	ATPase activity
CFK40_15500	COG0402	S-adenosylhomocysteine deaminase activity
CFK40_15515	COG1028	Short-chain dehydrogenase reductase Sdr
CFK40_15525	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CFK40_15530	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CFK40_15610	COG1595	DNA-templated transcription, initiation
CFK40_15625	COG0488	(ABC) transporter
CFK40_15630	COG1120	ATPase activity
CFK40_15635	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CFK40_15640	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CFK40_15655	COG0235	Class ii aldolase
CFK40_15660	COG0402	S-adenosylhomocysteine deaminase activity
CFK40_15670	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
CFK40_15675	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CFK40_15735	COG1757	Na H antiporter
CFK40_15750	COG0006	proline dipeptidase activity
CFK40_15760	COG0561	phosphatase activity
CFK40_15765	COG2391	methyltransferase activity
CFK40_15775	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CFK40_15790	COG0583	DNA-binding transcription factor activity
CFK40_15795	COG3180	Ammonia monooxygenase
CFK40_15805	COG2851	Citrate transporter
CFK40_15810	COG0583	DNA-binding transcription factor activity
CFK40_15815	COG2828	Protein conserved in bacteria
CFK40_15825	COG2050	protein possibly involved in aromatic compounds catabolism
CFK40_15830	COG1309	transcriptional regulator
CFK40_15860	COG3655	Transcriptional regulator
CFK40_15870	COG3739	integral membrane protein
CFK40_15880	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CFK40_15895	COG2367	Beta-lactamase
CFK40_15905	COG1647	Serine aminopeptidase, S33
CFK40_15935	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
CFK40_15945	COG1301	dicarboxylic acid transport
CFK40_15950	COG0179	Fumarylacetoacetate (FAA) hydrolase
CFK40_15955	COG4948	Mandelate Racemase Muconate Lactonizing
CFK40_15980	COG0456	acetyltransferase
CFK40_15980	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
CFK40_16000	COG0589	response to stress
CFK40_16005	COG0477	Major facilitator Superfamily
CFK40_16020	COG2514	catechol 2,3-dioxygenase activity
CFK40_16025	COG2259	Doxx family
CFK40_16035	COG2910	NAD(P)H-binding
CFK40_16055	COG1846	Transcriptional regulator
CFK40_16060	COG0456	acetyltransferase
CFK40_16065	COG2808	Putative FMN-binding domain
CFK40_16120	COG1132	(ABC) transporter
CFK40_16125	COG1132	(ABC) transporter
CFK40_16130	COG2382	esterase
CFK40_16135	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
CFK40_16145	COG2323	membrane
CFK40_16150	COG1846	Transcriptional regulator
CFK40_16155	COG0346	lactoylglutathione lyase activity
CFK40_16170	COG1408	metallophosphoesterase
CFK40_16175	COG0726	polysaccharide deacetylase
CFK40_16180	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CFK40_16185	COG0789	Transcriptional regulator
CFK40_16190	COG1253	flavin adenine dinucleotide binding
CFK40_16230	COG2323	membrane
CFK40_16245	COG0318	PFAM AMP-dependent synthetase and ligase
CFK40_16250	COG0004	ammonium transporteR
CFK40_16255	COG0347	Belongs to the P(II) protein family
CFK40_16295	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CFK40_16310	COG1522	sequence-specific DNA binding
CFK40_16310	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CFK40_16315	COG1028	Short-chain dehydrogenase reductase Sdr
CFK40_16325	COG3871	stress protein (general stress protein 26)
CFK40_16330	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CFK40_16335	COG2155	Conserved Protein
CFK40_16350	COG1533	DNA photolyase activity
CFK40_16380	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CFK40_16390	COG1028	Short-chain dehydrogenase reductase Sdr
CFK40_16395	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CFK40_16400	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CFK40_16405	COG5566	PFAM Mor transcription activator
CFK40_16415	COG0640	Transcriptional regulator
CFK40_16420	COG1368	sulfuric ester hydrolase activity
CFK40_16430	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CFK40_16435	COG1051	belongs to the nudix hydrolase family
CFK40_16495	COG0601	transmembrane transport
CFK40_16500	COG4608	Belongs to the ABC transporter superfamily
CFK40_16510	COG2239	Acts as a magnesium transporter
CFK40_16515	COG0772	Belongs to the SEDS family
CFK40_16520	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CFK40_16525	COG0564	pseudouridine synthase activity
CFK40_16530	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CFK40_16535	COG2357	RelA SpoT domain protein
CFK40_16540	COG4116	CYTH
CFK40_16545	COG2346	COG2346, Truncated hemoglobins
CFK40_16555	COG1164	Oligoendopeptidase f
CFK40_16570	COG1393	Belongs to the ArsC family
CFK40_16575	COG0456	acetyltransferase
CFK40_16590	COG1984	allophanate hydrolase subunit 2
CFK40_16595	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
CFK40_16600	COG1028	Short-chain dehydrogenase reductase Sdr
CFK40_16610	COG1473	amidohydrolase
CFK40_16620	COG0180	Tryptophanyl-tRNA synthetase
CFK40_16635	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CFK40_16640	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CFK40_16645	COG1744	ABC transporter substrate-binding protein PnrA-like
CFK40_16675	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
CFK40_16680	COG0314	molybdopterin synthase activity
CFK40_16685	COG1763	Mo-molybdopterin cofactor biosynthetic process
CFK40_16690	COG2151	metal-sulfur cluster biosynthetic enzyme
CFK40_16695	COG1073	alpha beta
CFK40_16700	COG0561	phosphatase activity
CFK40_16715	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CFK40_16720	COG1307	EDD domain protein, DegV family
CFK40_16725	COG0366	Alpha amylase catalytic
CFK40_16730	COG0492	ferredoxin-NADP+ reductase activity
CFK40_16735	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CFK40_16740	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CFK40_16745	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CFK40_16755	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CFK40_16760	COG3344	reverse transcriptase
CFK40_16770	COG2311	Membrane
CFK40_16775	COG3949	Membrane
CFK40_16780	COG2814	Major facilitator Superfamily
CFK40_16785	COG3344	reverse transcriptase
CFK40_16800	COG2267	carboxylic ester hydrolase activity
CFK40_16805	COG1074	ATP-dependent DNA helicase activity
CFK40_16810	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
CFK40_16820	COG0398	Pfam SNARE associated Golgi protein
CFK40_16835	COG0318	PFAM AMP-dependent synthetase and ligase
CFK40_16840	COG0095	Lipoate-protein ligase
CFK40_16845	COG1234	tRNA 3'-trailer cleavage
CFK40_16870	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CFK40_16875	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CFK40_16880	COG2329	Antibiotic biosynthesis monooxygenase
CFK40_16890	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
CFK40_16895	COG2197	response regulator
CFK40_16900	COG4585	Histidine kinase
CFK40_16925	COG1473	amidohydrolase
CFK40_16930	COG4473	ABC transporter
CFK40_16935	COG1131	(ABC) transporter
CFK40_16940	COG0537	adenosine 5'-monophosphoramidase activity
CFK40_16975	COG4175	Glycine betaine
CFK40_16975	COG0517	IMP dehydrogenase activity
CFK40_16980	COG1510	regulation of RNA biosynthetic process
CFK40_17000	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CFK40_17010	COG3481	metal-dependent phosphohydrolase, HD sub domain
CFK40_17015	COG1510	regulation of RNA biosynthetic process
CFK40_17020	COG4717	serine-type aminopeptidase activity
CFK40_17025	COG0420	3'-5' exonuclease activity
CFK40_17030	COG1668	transmembrane transport
CFK40_17035	COG4152	abc transporter atp-binding protein
CFK40_17045	COG1024	Enoyl-CoA hydratase
CFK40_17050	COG3679	Belongs to the UPF0342 family
CFK40_17055	COG2508	Transcriptional regulator
CFK40_17060	COG3842	ATPase activity
CFK40_17070	COG0114	fumarate hydratase activity
CFK40_17080	COG2270	Major facilitator Superfamily
CFK40_17085	COG5582	Belongs to the UPF0302 family
CFK40_17090	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CFK40_17105	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
CFK40_17110	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CFK40_17115	COG0024	Methionine aminopeptidase
CFK40_17125	COG1028	Short-chain dehydrogenase reductase Sdr
CFK40_17130	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CFK40_17135	COG0626	cystathionine gamma-synthase activity
CFK40_17140	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CFK40_17145	COG1854	S-ribosylhomocysteine lyase activity
CFK40_17150	COG2226	methyltransferase
CFK40_17170	COG1191	sigma factor activity
CFK40_17180	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CFK40_17185	COG1132	(ABC) transporter
CFK40_17190	COG1132	(ABC) transporter
CFK40_17220	COG0656	L-ascorbic acid biosynthetic process
CFK40_17225	COG4175	Glycine betaine
CFK40_17225	COG3448	diguanylate cyclase activity
CFK40_17230	COG4176	ABC-type proline glycine betaine transport system permease component
CFK40_17245	COG2409	Drug exporters of the RND superfamily
CFK40_17245	COG1033	growth of symbiont in host cell
CFK40_17250	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CFK40_17255	COG0534	Mate efflux family protein
CFK40_17260	COG1012	belongs to the aldehyde dehydrogenase family
CFK40_17275	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CFK40_17280	COG2252	PERMEase
CFK40_17285	COG0508	dehydrogenase complex catalyzes the overall conversion of
CFK40_17290	COG0567	Dehydrogenase, E1 component
CFK40_17305	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CFK40_17330	COG4946	Tricorn protease homolog
CFK40_17330	COG0823	Involved in the tonB-independent uptake of proteins
CFK40_17330	COG1506	peptidase
CFK40_17340	COG2318	DinB family
CFK40_17355	COG1131	(ABC) transporter
CFK40_17365	COG2197	response regulator
CFK40_17375	COG4585	Histidine kinase
CFK40_17400	COG0697	spore germination
CFK40_17405	COG2814	Major facilitator Superfamily
CFK40_17425	COG0318	PFAM AMP-dependent synthetase and ligase
CFK40_17430	COG1879	ABC-type sugar transport system periplasmic component
CFK40_17435	COG1172	Belongs to the binding-protein-dependent transport system permease family
CFK40_17440	COG1129	ABC transporter
CFK40_17445	COG1869	D-ribose catabolic process
CFK40_17450	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CFK40_17455	COG1609	Transcriptional regulator
CFK40_17460	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CFK40_17465	COG5522	Integral membrane protein (intg_mem_TP0381)
CFK40_17470	COG4608	Belongs to the ABC transporter superfamily
CFK40_17475	COG0444	Belongs to the ABC transporter superfamily
CFK40_17480	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CFK40_17485	COG0601	transmembrane transport
CFK40_17490	COG4166	transmembrane transport
CFK40_17505	COG1404	Belongs to the peptidase S8 family
CFK40_17520	COG0471	metal ion transport
CFK40_17560	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CFK40_17565	COG3250	beta-galactosidase activity
CFK40_17570	COG2211	Major facilitator Superfamily
CFK40_17575	COG4753	response regulator
CFK40_17575	COG2207	Transcriptional regulator
CFK40_17580	COG2972	Histidine kinase
CFK40_17595	COG3623	hexulose-6-phosphate isomerase
CFK40_17615	COG0395	ABC-type sugar transport system, permease component
CFK40_17625	COG5578	integral membrane protein
CFK40_17630	COG2211	Major facilitator Superfamily
CFK40_17645	COG0673	inositol 2-dehydrogenase activity
CFK40_17650	COG0673	inositol 2-dehydrogenase activity
CFK40_17670	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CFK40_17680	COG0800	Aldolase
CFK40_17685	COG1028	Short-chain dehydrogenase reductase Sdr
CFK40_17690	COG1312	Catalyzes the dehydration of D-mannonate
CFK40_17695	COG1904	glucuronate isomerase
CFK40_17715	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CFK40_17720	COG2132	Multicopper oxidase
CFK40_17725	COG0058	SHG alpha-glucan phosphorylase activity
CFK40_17730	COG0297	glycogen (starch) synthase activity
CFK40_17735	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CFK40_17740	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CFK40_17745	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CFK40_17750	COG1523	belongs to the glycosyl hydrolase 13 family
CFK40_17755	COG2130	NADP-dependent
CFK40_17760	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CFK40_17785	COG2233	PERMEase
CFK40_17795	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CFK40_17800	COG2508	Transcriptional regulator
CFK40_17805	COG1288	antiporter activity
CFK40_17810	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CFK40_17815	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CFK40_17820	COG1953	Uracil, thiamine, allantoin
CFK40_17830	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
CFK40_17835	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
CFK40_17840	COG3257	ureidoglycine aminohydrolase activity
CFK40_17845	COG0549	Belongs to the carbamate kinase family
CFK40_17850	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CFK40_17855	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CFK40_17860	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CFK40_17875	COG2814	Major facilitator Superfamily
CFK40_17885	COG2124	cytochrome p450
CFK40_17905	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CFK40_17930	COG1966	Carbon starvation protein
CFK40_17935	COG3279	Response regulator of the LytR AlgR family
CFK40_17940	COG3275	phosphorelay sensor kinase activity
CFK40_17970	COG0346	lactoylglutathione lyase activity
CFK40_17985	COG0482	sulfurtransferase activity
CFK40_18005	COG1131	(ABC) transporter
CFK40_18015	COG3654	unkown
CFK40_18020	COG4474	Belongs to the UPF0398 family
CFK40_18030	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CFK40_18040	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CFK40_18045	COG1970	mechanosensitive ion channel activity
CFK40_18065	COG1278	Cold shock
CFK40_18070	COG0529	Catalyzes the synthesis of activated sulfate
CFK40_18075	COG3273	potassium ion transport
CFK40_18075	COG0471	metal ion transport
CFK40_18080	COG2046	Belongs to the sulfate adenylyltransferase family
CFK40_18105	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CFK40_18110	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
CFK40_18115	COG0175	sulfate reduction
CFK40_18120	COG0626	cystathionine gamma-synthase activity
CFK40_18125	COG0646	methionine synthase
CFK40_18125	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
CFK40_18140	COG1522	sequence-specific DNA binding
CFK40_18145	COG0436	Aminotransferase
CFK40_18150	COG1012	belongs to the aldehyde dehydrogenase family
CFK40_18155	COG1227	inorganic diphosphatase activity
CFK40_18160	COG0723	plastoquinol--plastocyanin reductase activity
CFK40_18160	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CFK40_18170	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CFK40_18180	COG0659	secondary active sulfate transmembrane transporter activity
CFK40_18185	COG2364	Membrane
CFK40_18190	COG0697	spore germination
CFK40_18205	COG1012	belongs to the aldehyde dehydrogenase family
CFK40_18215	COG2015	COG2015, Alkyl sulfatase and related hydrolases
CFK40_18240	COG1609	Transcriptional regulator
CFK40_18250	COG0730	response to heat
CFK40_18255	COG0583	DNA-binding transcription factor activity
CFK40_18265	COG2015	COG2015, Alkyl sulfatase and related hydrolases
CFK40_18280	COG1024	Enoyl-CoA hydratase
CFK40_18285	COG1028	Short-chain dehydrogenase reductase Sdr
CFK40_18295	COG1250	3-hydroxyacyl-CoA dehydrogenase
CFK40_18300	COG0318	PFAM AMP-dependent synthetase and ligase
CFK40_18305	COG1960	acyl-CoA dehydrogenase activity
CFK40_18315	COG1024	Enoyl-CoA hydratase
CFK40_18320	COG0183	Belongs to the thiolase family
CFK40_18325	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CFK40_18330	COG2086	electron transfer activity
CFK40_18425	COG4974	Belongs to the 'phage' integrase family
CFK40_18525	COG0512	Glutamine amidotransferase of anthranilate synthase
CFK40_18535	COG0735	belongs to the Fur family
CFK40_18540	COG2096	Adenosyltransferase
CFK40_18545	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CFK40_18555	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CFK40_18565	COG0745	RESPONSE REGULATOR receiver
CFK40_18570	COG2205	protein histidine kinase activity
CFK40_18575	COG1136	(ABC) transporter
CFK40_18580	COG0577	efflux transmembrane transporter activity
CFK40_18585	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CFK40_18590	COG1132	(ABC) transporter
CFK40_18595	COG3557	Belongs to the UPF0374 family
CFK40_18605	COG1194	a g-specific adenine glycosylase
CFK40_18610	COG1988	membrane-bound metal-dependent
CFK40_18620	COG0300	oxidoreductase activity
CFK40_18625	COG2137	regulation of response to DNA damage stimulus
CFK40_18630	COG1090	epimerase
CFK40_18650	COG1131	(ABC) transporter
CFK40_18665	COG0542	response to heat
CFK40_18670	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CFK40_18680	COG3850	Histidine kinase
CFK40_18680	COG5002	protein histidine kinase activity
CFK40_18685	COG0745	RESPONSE REGULATOR receiver
CFK40_18690	COG0471	metal ion transport
CFK40_18695	COG1929	Belongs to the glycerate kinase type-1 family
CFK40_18705	COG2056	Na+-H+ antiporter family
CFK40_18720	COG0477	Major facilitator Superfamily
CFK40_18725	COG0765	amino acid transport
CFK40_18730	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CFK40_18735	COG2217	Heavy metal translocating P-type atpase
CFK40_18740	COG1295	ribonuclease BN
CFK40_18750	COG1115	amino acid carrier protein
CFK40_18755	COG2135	peptidase activity
CFK40_18760	COG2066	Belongs to the glutaminase family
CFK40_18770	COG2340	Cysteine-rich secretory protein family
CFK40_18775	COG1077	Cell shape determining protein MreB Mrl
CFK40_18780	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CFK40_18785	COG1960	acyl-CoA dehydrogenase activity
CFK40_18790	COG1012	belongs to the aldehyde dehydrogenase family
CFK40_18800	COG1414	Transcriptional regulator
CFK40_18810	COG1012	belongs to the aldehyde dehydrogenase family
CFK40_18815	COG0028	Belongs to the TPP enzyme family
CFK40_18820	COG0436	Aminotransferase
CFK40_18825	COG1757	Na H antiporter
CFK40_18835	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
CFK40_18845	COG0733	neurotransmitter:sodium symporter activity
CFK40_18850	COG0446	pyridine nucleotide-disulphide oxidoreductase
CFK40_18860	COG0861	Integral membrane protein TerC family
CFK40_18880	COG0488	(ABC) transporter
CFK40_18890	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CFK40_18895	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CFK40_18895	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CFK40_18900	COG0307	riboflavin synthase, alpha
CFK40_18905	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CFK40_18905	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CFK40_18940	COG1595	DNA-templated transcription, initiation
CFK40_18950	COG1199	ATP-dependent helicase activity
CFK40_18955	COG0564	pseudouridine synthase activity
CFK40_18960	COG0166	Belongs to the GPI family
CFK40_18980	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CFK40_18985	COG0601	transmembrane transport
CFK40_18995	COG0829	nickel cation binding
CFK40_19000	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CFK40_19005	COG0830	nickel cation binding
CFK40_19010	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
CFK40_19015	COG0804	urea catabolic process
CFK40_19020	COG0832	Belongs to the urease beta subunit family
CFK40_19025	COG0831	urea catabolic process
CFK40_19045	COG0494	nUDIX hydrolase
CFK40_19070	COG0346	lactoylglutathione lyase activity
CFK40_19075	COG0346	lactoylglutathione lyase activity
CFK40_19095	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CFK40_19110	COG0288	reversible hydration of carbon dioxide
CFK40_19115	COG0277	FAD linked oxidase domain protein
CFK40_19120	COG1785	Belongs to the alkaline phosphatase family
CFK40_19130	COG0109	protoheme IX farnesyltransferase activity
CFK40_19140	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CFK40_19175	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
CFK40_19180	COG4807	Protein conserved in bacteria
CFK40_19190	COG1027	Aspartate ammonia-lyase
CFK40_19195	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CFK40_19205	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CFK40_19215	COG1597	lipid kinase activity
CFK40_19220	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CFK40_19225	COG0154	amidase activity
CFK40_19230	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CFK40_19240	COG1012	belongs to the aldehyde dehydrogenase family
CFK40_19245	COG4851	CamS sex pheromone cAM373 precursor
CFK40_19250	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CFK40_19255	COG0210	DNA helicase
CFK40_19260	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
CFK40_19265	COG4496	protein, YerC YecD
CFK40_19270	COG1470	cell adhesion involved in biofilm formation
CFK40_19275	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
CFK40_19280	COG0151	Belongs to the GarS family
CFK40_19285	COG0138	bifunctional purine biosynthesis protein purh
CFK40_19290	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CFK40_19295	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CFK40_19300	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CFK40_19305	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CFK40_19310	COG0047	phosphoribosylformylglycinamidine synthase activity
CFK40_19315	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CFK40_19320	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CFK40_19325	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CFK40_19330	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CFK40_19335	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CFK40_19340	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CFK40_19345	COG2233	PERMEase
CFK40_19350	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
CFK40_19355	COG2258	MOSC domain
CFK40_19360	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CFK40_19365	COG2814	Major facilitator Superfamily
CFK40_19370	COG2252	PERMEase
CFK40_19375	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CFK40_19375	COG0519	Catalyzes the synthesis of GMP from XMP
CFK40_19380	COG1305	Transglutaminase-like
CFK40_19385	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
CFK40_19390	COG0714	Associated with various cellular activities
CFK40_19400	COG0531	amino acid
CFK40_19405	COG0697	spore germination
CFK40_19425	COG4326	sporulation control protein
CFK40_19430	COG0569	domain protein
CFK40_19435	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CFK40_19440	COG0584	glycerophosphoryl diester phosphodiesterase
CFK40_19445	COG2356	endonuclease I
CFK40_19450	COG3639	organic phosphonate transmembrane transporter activity
CFK40_19455	COG3639	organic phosphonate transmembrane transporter activity
CFK40_19460	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
CFK40_19470	COG0613	PHP domain protein
CFK40_19475	COG4778	phosphonate C-P lyase system protein PhnL
CFK40_19480	COG3454	Phosphonate metabolism
CFK40_19485	COG4107	phosphonate C-P lyase system protein PhnK
CFK40_19490	COG3627	carbon phosphorus lyase activity
CFK40_19510	COG2188	Transcriptional regulator
CFK40_19525	COG2814	Major facilitator Superfamily
CFK40_19530	COG0024	Methionine aminopeptidase
CFK40_19540	COG1012	belongs to the aldehyde dehydrogenase family
CFK40_19545	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CFK40_19565	COG0459	protein refolding
CFK40_19570	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CFK40_19575	COG1266	CAAX protease self-immunity
CFK40_19595	COG0640	Transcriptional regulator
CFK40_19615	COG5504	Zn-dependent protease
CFK40_19625	COG2226	methyltransferase
CFK40_19640	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
CFK40_19650	COG0488	(ABC) transporter
CFK40_19655	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CFK40_19660	COG0456	acetyltransferase
CFK40_19665	COG1214	PFAM Peptidase M22, glycoprotease
CFK40_19670	COG0802	atpase or kinase
CFK40_19675	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
CFK40_19765	COG3091	SprT-like family
CFK40_19770	COG0753	catalase activity
CFK40_19775	COG2183	response to ionizing radiation
CFK40_19780	COG2208	phosphoserine phosphatase activity
CFK40_19785	COG1191	sigma factor activity
CFK40_19790	COG2172	sigma factor antagonist activity
CFK40_19795	COG1366	Belongs to the anti-sigma-factor antagonist family
CFK40_19800	COG2208	phosphoserine phosphatase activity
CFK40_19805	COG2172	sigma factor antagonist activity
CFK40_19810	COG1366	Belongs to the anti-sigma-factor antagonist family
CFK40_19815	COG1366	Belongs to the anti-sigma-factor antagonist family
CFK40_19820	COG2337	Toxic component of a toxin-antitoxin (TA) module
CFK40_19830	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CFK40_19835	COG1366	Belongs to the anti-sigma-factor antagonist family
CFK40_19840	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
CFK40_19850	COG0736	holo-[acyl-carrier-protein] synthase activity
CFK40_19855	COG0705	Rhomboid family
CFK40_19865	COG3428	Bacterial PH domain
CFK40_19870	COG3402	PFAM membrane-flanked domain
CFK40_19875	COG0513	Belongs to the DEAD box helicase family
CFK40_19885	COG1307	EDD domain protein, DegV family
CFK40_19890	COG1647	Serine aminopeptidase, S33
CFK40_19910	COG1131	(ABC) transporter
CFK40_19935	COG1597	lipid kinase activity
CFK40_19940	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
CFK40_19945	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
CFK40_19950	COG3639	organic phosphonate transmembrane transporter activity
CFK40_19955	COG3639	organic phosphonate transmembrane transporter activity
CFK40_19960	COG0737	Belongs to the 5'-nucleotidase family
CFK40_19970	COG3850	Histidine kinase
CFK40_19970	COG5002	protein histidine kinase activity
CFK40_19975	COG0745	RESPONSE REGULATOR receiver
CFK40_19985	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CFK40_20005	COG2843	Capsule synthesis protein
CFK40_20010	COG4325	translation initiation factor activity
CFK40_20030	COG1595	DNA-templated transcription, initiation
CFK40_20035	COG1131	(ABC) transporter
CFK40_20040	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
CFK40_20050	COG2188	Transcriptional regulator
CFK40_20055	COG0366	Alpha amylase catalytic
CFK40_20060	COG1263	PTS System
CFK40_20060	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CFK40_20070	COG4721	ABC-type cobalt transport system, permease component
CFK40_20075	COG1122	ATPase activity
CFK40_20080	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
CFK40_20090	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CFK40_20100	COG5002	protein histidine kinase activity
CFK40_20100	COG3850	Histidine kinase
CFK40_20105	COG0745	RESPONSE REGULATOR receiver
CFK40_20110	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CFK40_20125	COG1131	(ABC) transporter
CFK40_20135	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CFK40_20140	COG2153	protein acetylation
CFK40_20145	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CFK40_20150	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CFK40_20155	COG2084	Dehydrogenase
CFK40_20165	COG2226	methyltransferase
CFK40_20170	COG1278	Cold shock
CFK40_20175	COG0183	Belongs to the thiolase family
CFK40_20180	COG0318	PFAM AMP-dependent synthetase and ligase
CFK40_20185	COG1268	BioY protein
CFK40_20215	COG0386	Belongs to the glutathione peroxidase family
CFK40_20220	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CFK40_20235	COG0351	phosphomethylpyrimidine kinase
CFK40_20240	COG2839	Protein conserved in bacteria
CFK40_20245	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CFK40_20250	COG1876	peptidase activity
CFK40_20255	COG0346	lactoylglutathione lyase activity
CFK40_20275	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CFK40_20280	COG0765	amino acid transport
CFK40_20285	COG0765	amino acid transport
CFK40_20290	COG1126	abc transporter atp-binding protein
CFK40_20295	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CFK40_20305	COG2832	Protein of unknown function (DUF454)
CFK40_20310	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CFK40_20315	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
CFK40_20320	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CFK40_20325	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CFK40_20330	COG0131	Imidazoleglycerol-phosphate dehydratase
CFK40_20335	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CFK40_20340	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CFK40_20345	COG0107	imidazoleglycerol-phosphate synthase activity
CFK40_20350	COG0140	phosphoribosyl-ATP diphosphatase activity
CFK40_20350	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CFK40_20355	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CFK40_20360	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CFK40_20365	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
CFK40_20370	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CFK40_20375	COG4876	unkown
CFK40_20380	COG2720	vancomycin resistance protein
CFK40_20385	COG1304	FMN binding
CFK40_20390	COG2514	catechol 2,3-dioxygenase activity
CFK40_20395	COG2076	Multidrug Resistance protein
CFK40_20400	COG2076	Multidrug Resistance protein
CFK40_20405	COG3226	Transcriptional regulator
CFK40_20410	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CFK40_20420	COG0656	L-ascorbic acid biosynthetic process
CFK40_20425	COG0488	(ABC) transporter
CFK40_20445	COG1268	BioY protein
CFK40_20450	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CFK40_20455	COG0519	Catalyzes the synthesis of GMP from XMP
CFK40_20460	COG2897	thiosulfate sulfurtransferase activity
CFK40_20465	COG2195	Cleaves the N-terminal amino acid of tripeptides
CFK40_20470	COG0702	epimerase
CFK40_20475	COG0400	carboxylic ester hydrolase activity
CFK40_20480	COG1876	peptidase activity
CFK40_20485	COG1418	mRNA catabolic process
CFK40_20490	COG1349	DNA-binding transcription factor activity
CFK40_20495	COG1105	Belongs to the carbohydrate kinase PfkB family
CFK40_20500	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CFK40_20500	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CFK40_20500	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CFK40_20510	COG0488	(ABC) transporter
CFK40_20515	COG4166	transmembrane transport
CFK40_20525	COG0778	Nitroreductase
CFK40_20530	COG1181	Belongs to the D-alanine--D-alanine ligase family
CFK40_20535	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CFK40_20540	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CFK40_20540	COG0512	Glutamine amidotransferase of anthranilate synthase
CFK40_20550	COG0134	indole-3-glycerol-phosphate synthase activity
CFK40_20555	COG0135	phosphoribosylanthranilate isomerase activity
CFK40_20560	COG0133	tryptophan synthase activity
CFK40_20565	COG0159	tryptophan synthase activity
CFK40_20570	COG3708	Transcriptional regulator
CFK40_20570	COG2207	Transcriptional regulator
CFK40_20590	COG0095	Lipoate-protein ligase
CFK40_20595	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CFK40_20605	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CFK40_20635	COG1131	(ABC) transporter
CFK40_20640	COG1725	Transcriptional regulator
CFK40_20655	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CFK40_20675	COG5577	PFAM Coat F domain
CFK40_20680	COG3104	oligopeptide transport