locus-tag	class	description
A21D_00024	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A21D_00024	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A21D_00039	COG3617	BRO family, N-terminal domain
A21D_00044	COG0582	viral genome integration into host DNA
A21D_00045	COG0719	Fe-S assembly protein
A21D_00046	COG0822	iron-sulfur transferase activity
A21D_00047	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A21D_00048	COG0719	Fe-S assembly protein
A21D_00049	COG0396	ATPase activity
A21D_00051	COG1464	Belongs to the NlpA lipoprotein family
A21D_00052	COG2011	ABC-type metal ion transport system permease component
A21D_00053	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A21D_00054	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A21D_00055	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
A21D_00056	COG0509	glycine decarboxylation via glycine cleavage system
A21D_00057	COG1393	Belongs to the ArsC family
A21D_00058	COG1960	acyl-CoA dehydrogenase activity
A21D_00059	COG0183	Belongs to the thiolase family
A21D_00060	COG1024	Enoyl-CoA hydratase
A21D_00060	COG1250	3-hydroxyacyl-CoA dehydrogenase
A21D_00062	COG1121	(ABC) transporter
A21D_00063	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A21D_00064	COG0735	belongs to the Fur family
A21D_00065	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
A21D_00068	COG2076	Multidrug Resistance protein
A21D_00069	COG2076	Multidrug Resistance protein
A21D_00071	COG3883	PFAM NLP P60 protein
A21D_00071	COG0791	NLP P60 protein
A21D_00072	COG2224	Isocitrate lyase
A21D_00073	COG4129	membrane
A21D_00074	COG2197	response regulator
A21D_00079	COG0586	Pfam SNARE associated Golgi protein
A21D_00080	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A21D_00083	COG0517	IMP dehydrogenase activity
A21D_00087	COG0745	RESPONSE REGULATOR receiver
A21D_00088	COG2205	protein histidine kinase activity
A21D_00089	COG1136	(ABC) transporter
A21D_00090	COG0577	efflux transmembrane transporter activity
A21D_00093	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
A21D_00094	COG0557	exoribonuclease II activity
A21D_00095	COG1647	Serine aminopeptidase, S33
A21D_00096	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
A21D_00099	COG0084	hydrolase, TatD family'
A21D_00100	COG1116	anion transmembrane transporter activity
A21D_00101	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A21D_00103	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A21D_00104	COG0148	phosphopyruvate hydratase activity
A21D_00105	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
A21D_00106	COG0149	triose-phosphate isomerase activity
A21D_00107	COG0126	phosphoglycerate kinase activity
A21D_00112	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
A21D_00113	COG0328	RNA-DNA hybrid ribonuclease activity
A21D_00114	COG0710	3-dehydroquinate dehydratase activity
A21D_00115	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
A21D_00119	COG1984	allophanate hydrolase subunit 2
A21D_00120	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
A21D_00121	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
A21D_00122	COG1914	H( )-stimulated, divalent metal cation uptake system
A21D_00127	COG2826	transposase and inactivated derivatives, IS30 family
A21D_00129	COG0740	serine-type endopeptidase activity
A21D_00130	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
A21D_00131	COG1481	regulation of sporulation
A21D_00132	COG0391	Required for morphogenesis under gluconeogenic growth conditions
A21D_00133	COG1660	Displays ATPase and GTPase activities
A21D_00134	COG1051	belongs to the nudix hydrolase family
A21D_00135	COG0492	ferredoxin-NADP+ reductase activity
A21D_00136	COG0457	Tetratricopeptide repeat
A21D_00137	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
A21D_00138	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
A21D_00139	COG0110	maltose O-acetyltransferase activity
A21D_00140	COG0546	phosphoglycolate phosphatase activity
A21D_00141	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
A21D_00142	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
A21D_00143	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
A21D_00144	COG1950	PFAM Membrane protein of
A21D_00145	COG1983	PspC domain protein
A21D_00147	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
A21D_00148	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
A21D_00149	COG0556	nucleotide-excision repair
A21D_00150	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
A21D_00151	COG0726	polysaccharide deacetylase
A21D_00153	COG0793	Belongs to the peptidase S41A family
A21D_00153	COG3409	Peptidoglycan-binding domain 1 protein
A21D_00154	COG0739	heme binding
A21D_00155	COG2177	Part of the ABC transporter FtsEX involved in
A21D_00156	COG2884	Cell division ATP-binding protein ftsE
A21D_00158	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
A21D_00159	COG0653	protein targeting
A21D_00161	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A21D_00162	COG1957	nucleoside hydrolase
A21D_00164	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
A21D_00166	COG1516	flagellar protein fliS
A21D_00167	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
A21D_00168	COG1334	flagellar protein FlaG
A21D_00169	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
A21D_00170	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
A21D_00172	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
A21D_00173	COG1256	bacterial-type flagellum assembly
A21D_00173	COG4786	Flagellar basal body rod
A21D_00177	COG1040	competence protein
A21D_00178	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
A21D_00181	COG2197	response regulator
A21D_00183	COG1511	domain protein
A21D_00184	COG1307	EDD domain protein, DegV family
A21D_00185	COG2197	response regulator
A21D_00187	COG1739	Uncharacterized protein family UPF0029
A21D_00188	COG0363	glucosamine-6-phosphate deaminase activity
A21D_00189	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
A21D_00192	COG1316	TRANSCRIPTIONal
A21D_00193	COG0768	penicillin binding
A21D_00195	COG1012	belongs to the aldehyde dehydrogenase family
A21D_00197	COG0561	phosphatase activity
A21D_00198	COG2814	Major facilitator Superfamily
A21D_00199	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
A21D_00200	COG0471	metal ion transport
A21D_00201	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
A21D_00203	COG2814	Major facilitator Superfamily
A21D_00204	COG2807	transmembrane transport
A21D_00206	COG1368	sulfuric ester hydrolase activity
A21D_00207	COG0840	transmembrane signaling receptor activity
A21D_00208	COG0840	transmembrane signaling receptor activity
A21D_00209	COG1012	belongs to the aldehyde dehydrogenase family
A21D_00215	COG2971	BadF BadG BcrA BcrD
A21D_00218	COG1447	Phosphotransferase system cellobiose-specific component IIA
A21D_00222	COG1486	melibiose metabolic process
A21D_00223	COG1609	Transcriptional regulator
A21D_00225	COG3833	ABC-type maltose transport systems, permease component
A21D_00226	COG1175	transmembrane transport
A21D_00227	COG2182	Extracellular solute-binding protein
A21D_00236	COG0788	formyltetrahydrofolate deformylase activity
A21D_00237	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
A21D_00238	COG3639	organic phosphonate transmembrane transporter activity
A21D_00239	COG3639	organic phosphonate transmembrane transporter activity
A21D_00247	COG1473	amidohydrolase
A21D_00249	COG1971	Probably functions as a manganese efflux pump
A21D_00250	COG1028	Short-chain dehydrogenase reductase Sdr
A21D_00251	COG2996	Protein conserved in bacteria
A21D_00253	COG0561	phosphatase activity
A21D_00254	COG2059	Chromate
A21D_00255	COG2059	Chromate
A21D_00257	COG1522	sequence-specific DNA binding
A21D_00258	COG3275	phosphorelay sensor kinase activity
A21D_00259	COG3279	Response regulator of the LytR AlgR family
A21D_00260	COG1966	Carbon starvation protein
A21D_00261	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
A21D_00262	COG1461	Dihydroxyacetone kinase
A21D_00263	COG2376	Dihydroxyacetone kinase
A21D_00264	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
A21D_00265	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
A21D_00268	COG0367	asparagine synthase
A21D_00271	COG0601	transmembrane transport
A21D_00272	COG4608	Belongs to the ABC transporter superfamily
A21D_00275	COG1476	TRANSCRIPTIONal
A21D_00280	COG1940	carbohydrate kinase activity
A21D_00282	COG5426	von Willebrand factor, type A
A21D_00283	COG0395	ABC-type sugar transport system, permease component
A21D_00284	COG1175	transmembrane transport
A21D_00287	COG0366	Alpha amylase catalytic
A21D_00288	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
A21D_00291	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A21D_00292	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
A21D_00293	COG0066	3-isopropylmalate dehydratase activity
A21D_00294	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
A21D_00295	COG0473	3-isopropylmalate dehydrogenase activity
A21D_00296	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A21D_00297	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
A21D_00298	COG0440	acetolactate synthase activity
A21D_00299	COG0028	Belongs to the TPP enzyme family
A21D_00300	COG0129	dihydroxy-acid dehydratase activity
A21D_00301	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A21D_00302	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
A21D_00303	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
A21D_00304	COG2814	Major facilitator Superfamily
A21D_00309	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A21D_00314	COG1247	-acetyltransferase
A21D_00316	COG0456	acetyltransferase
A21D_00320	COG4474	Belongs to the UPF0398 family
A21D_00324	COG1970	mechanosensitive ion channel activity
A21D_00326	COG1694	Mazg nucleotide pyrophosphohydrolase
A21D_00328	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A21D_00329	COG1227	inorganic diphosphatase activity
A21D_00330	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A21D_00332	COG0659	secondary active sulfate transmembrane transporter activity
A21D_00334	COG0456	acetyltransferase
A21D_00334	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
A21D_00336	COG1271	oxidase subunit
A21D_00337	COG1294	oxidase, subunit
A21D_00338	COG4988	ABC transporter
A21D_00339	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
A21D_00340	COG3142	Participates in the control of copper homeostasis
A21D_00341	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
A21D_00342	COG1940	carbohydrate kinase activity
A21D_00343	COG1621	beta-fructofuranosidase activity
A21D_00349	COG1764	response to oxidative stress
A21D_00354	COG0083	homoserine kinase activity
A21D_00357	COG1028	Short-chain dehydrogenase reductase Sdr
A21D_00358	COG4708	membrane
A21D_00365	COG4932	domain protein
A21D_00365	COG4886	Leucine-rich repeat (LRR) protein
A21D_00369	COG3279	Response regulator of the LytR AlgR family
A21D_00370	COG1454	alcohol dehydrogenase
A21D_00370	COG1012	belongs to the aldehyde dehydrogenase family
A21D_00371	COG2207	Transcriptional regulator
A21D_00374	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
A21D_00378	COG3327	negative regulation of DNA-templated transcription, initiation
A21D_00379	COG1024	Enoyl-CoA hydratase
A21D_00380	COG0183	Belongs to the thiolase family
A21D_00381	COG1250	3-hydroxyacyl-CoA dehydrogenase
A21D_00382	COG1012	belongs to the aldehyde dehydrogenase family
A21D_00383	COG1024	Enoyl-CoA hydratase
A21D_00386	COG2151	metal-sulfur cluster biosynthetic enzyme
A21D_00389	COG3396	Phenylacetate-CoA oxygenase
A21D_00390	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
A21D_00392	COG0492	ferredoxin-NADP+ reductase activity
A21D_00393	COG0235	Class ii aldolase
A21D_00394	COG0235	Class ii aldolase
A21D_00395	COG3775	system Galactitol-specific IIC component
A21D_00396	COG3414	Phosphotransferase system galactitol-specific IIB component
A21D_00397	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A21D_00402	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
A21D_00403	COG1335	isochorismatase
A21D_00405	COG0191	fructose-bisphosphate aldolase activity
A21D_00406	COG3962	Belongs to the TPP enzyme family
A21D_00407	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A21D_00409	COG1012	belongs to the aldehyde dehydrogenase family
A21D_00410	COG1349	DNA-binding transcription factor activity
A21D_00411	COG1942	4-Oxalocrotonate Tautomerase
A21D_00412	COG0673	inositol 2-dehydrogenase activity
A21D_00413	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A21D_00414	COG0673	inositol 2-dehydrogenase activity
A21D_00415	COG1082	Xylose isomerase domain protein TIM barrel
A21D_00416	COG2814	Major facilitator Superfamily
A21D_00418	COG3876	Protein conserved in bacteria
A21D_00419	COG1447	Phosphotransferase system cellobiose-specific component IIA
A21D_00421	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A21D_00423	COG1486	melibiose metabolic process
A21D_00424	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A21D_00424	COG3711	transcriptional antiterminator
A21D_00425	COG1438	arginine binding
A21D_00426	COG0549	Belongs to the carbamate kinase family
A21D_00428	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
A21D_00430	COG0018	arginyl-trna synthetase
A21D_00432	COG3835	regulator
A21D_00433	COG2610	gluconate transmembrane transporter activity
A21D_00434	COG1929	Belongs to the glycerate kinase type-1 family
A21D_00435	COG3527	Alpha-acetolactate decarboxylase
A21D_00437	COG0681	Belongs to the peptidase S26 family
A21D_00439	COG1785	Belongs to the alkaline phosphatase family
A21D_00440	COG0584	glycerophosphoryl diester phosphodiesterase
A21D_00448	COG1396	sequence-specific DNA binding
A21D_00450	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
A21D_00455	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
A21D_00461	COG2801	Transposase and inactivated derivatives
A21D_00465	COG0456	acetyltransferase
A21D_00466	COG1737	Transcriptional regulator
A21D_00467	COG3876	Protein conserved in bacteria
A21D_00469	COG1472	Belongs to the glycosyl hydrolase 3 family
A21D_00471	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
A21D_00472	COG1122	ATPase activity
A21D_00476	COG0183	Belongs to the thiolase family
A21D_00477	COG0318	PFAM AMP-dependent synthetase and ligase
A21D_00478	COG1268	BioY protein
A21D_00479	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
A21D_00480	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A21D_00482	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A21D_00482	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A21D_00482	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A21D_00483	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A21D_00483	COG3711	transcriptional antiterminator
A21D_00486	COG3732	PTS system glucitol sorbitol-specific
A21D_00492	COG0840	transmembrane signaling receptor activity
A21D_00493	COG0277	FAD linked oxidase domain protein
A21D_00495	COG0531	amino acid
A21D_00496	COG0527	aspartate kinase activity
A21D_00497	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A21D_00497	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A21D_00500	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
A21D_00501	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A21D_00503	COG3486	L-lysine 6-monooxygenase (NADPH) activity
A21D_00504	COG4977	sequence-specific DNA binding
A21D_00511	COG1396	sequence-specific DNA binding
A21D_00513	COG2851	Citrate transporter
A21D_00514	COG4565	transcriptional regulatory protein
A21D_00515	COG3290	protein histidine kinase activity
A21D_00525	COG3279	Response regulator of the LytR AlgR family
A21D_00528	COG2378	regulation of single-species biofilm formation
A21D_00529	COG0693	protein deglycase activity
A21D_00534	COG1316	TRANSCRIPTIONal
A21D_00540	COG0438	transferase activity, transferring glycosyl groups
A21D_00541	COG0438	transferase activity, transferring glycosyl groups
A21D_00545	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
A21D_00546	COG1210	Utp--glucose-1-phosphate uridylyltransferase
A21D_00549	COG4464	protein tyrosine phosphatase activity
A21D_00550	COG0489	protein tyrosine kinase activity
A21D_00551	COG3944	biosynthesis protein
A21D_00552	COG0791	NLP P60 protein
A21D_00552	COG1388	LysM domain
A21D_00553	COG2706	6-phosphogluconolactonase activity
A21D_00555	COG3397	chitin binding
A21D_00556	COG2188	Transcriptional regulator
A21D_00557	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A21D_00559	COG3964	amidohydrolase
A21D_00560	COG5578	integral membrane protein
A21D_00561	COG0395	ABC-type sugar transport system, permease component
A21D_00562	COG4209	transmembrane transport
A21D_00565	COG0432	Pfam Uncharacterised protein family UPF0047
A21D_00570	COG2814	Major facilitator Superfamily
A21D_00573	COG1278	Cold shock
A21D_00575	COG2217	Heavy metal translocating P-type atpase
A21D_00576	COG1937	Protein conserved in bacteria
A21D_00578	COG1268	BioY protein
A21D_00579	COG0300	oxidoreductase activity
A21D_00582	COG2856	Zn peptidase
A21D_00587	COG4585	Histidine kinase
A21D_00588	COG2197	response regulator
A21D_00589	COG0730	response to heat
A21D_00590	COG0726	polysaccharide deacetylase
A21D_00594	COG0840	transmembrane signaling receptor activity
A21D_00595	COG0386	Belongs to the glutathione peroxidase family
A21D_00597	COG1126	abc transporter atp-binding protein
A21D_00598	COG0765	amino acid transport
A21D_00599	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A21D_00601	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
A21D_00602	COG1335	isochorismatase
A21D_00603	COG2839	Protein conserved in bacteria
A21D_00604	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
A21D_00605	COG1876	peptidase activity
A21D_00607	COG0673	inositol 2-dehydrogenase activity
A21D_00609	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
A21D_00611	COG0765	amino acid transport
A21D_00612	COG0765	amino acid transport
A21D_00613	COG1126	abc transporter atp-binding protein
A21D_00615	COG3344	reverse transcriptase
A21D_00616	COG0812	UDP-N-acetylmuramate dehydrogenase activity
A21D_00618	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
A21D_00619	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
A21D_00620	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
A21D_00621	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
A21D_00622	COG0131	Imidazoleglycerol-phosphate dehydratase
A21D_00623	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
A21D_00624	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
A21D_00625	COG0107	imidazoleglycerol-phosphate synthase activity
A21D_00626	COG0140	phosphoribosyl-ATP diphosphatase activity
A21D_00626	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
A21D_00627	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A21D_00629	COG4607	ABC-type enterochelin transport system periplasmic component
A21D_00630	COG4604	ABC transporter, ATP-binding protein
A21D_00631	COG4605	iron ion homeostasis
A21D_00632	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A21D_00634	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
A21D_00635	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A21D_00636	COG1304	FMN binding
A21D_00637	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A21D_00639	COG0656	L-ascorbic acid biosynthetic process
A21D_00640	COG0488	(ABC) transporter
A21D_00642	COG1388	LysM domain
A21D_00642	COG3858	chitin binding
A21D_00644	COG0840	transmembrane signaling receptor activity
A21D_00646	COG0577	efflux transmembrane transporter activity
A21D_00646	COG1136	(ABC) transporter
A21D_00648	COG2818	Glycosylase
A21D_00655	COG1181	Belongs to the D-alanine--D-alanine ligase family
A21D_00662	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
A21D_00663	COG0512	Glutamine amidotransferase of anthranilate synthase
A21D_00664	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
A21D_00665	COG0134	indole-3-glycerol-phosphate synthase activity
A21D_00666	COG0135	phosphoribosylanthranilate isomerase activity
A21D_00667	COG0133	tryptophan synthase activity
A21D_00668	COG0159	tryptophan synthase activity
A21D_00671	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A21D_00674	COG1131	(ABC) transporter
A21D_00675	COG1725	Transcriptional regulator
A21D_00676	COG0708	Exodeoxyribonuclease III
A21D_00678	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A21D_00684	COG5506	Protein of unknown function (DUF1694)
A21D_00685	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A21D_00688	COG0693	protein deglycase activity
A21D_00689	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A21D_00690	COG4145	pantothenate transmembrane transporter activity
A21D_00700	COG3104	oligopeptide transport
A21D_00702	COG0346	lactoylglutathione lyase activity
A21D_00703	COG2323	membrane
A21D_00704	COG1827	regulation of RNA biosynthetic process
A21D_00705	COG1104	cysteine desulfurase activity
A21D_00706	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
A21D_00707	COG0157	Belongs to the NadC ModD family
A21D_00710	COG3654	unkown
A21D_00711	COG1525	nuclease
A21D_00711	COG0737	Belongs to the 5'-nucleotidase family
A21D_00711	COG4085	toxin activity
A21D_00728	COG0747	negative chemotaxis
A21D_00729	COG4608	Belongs to the ABC transporter superfamily
A21D_00730	COG0444	Belongs to the ABC transporter superfamily
A21D_00734	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
A21D_00735	COG0352	thiamine-phosphate diphosphorylase activity
A21D_00737	COG0789	Transcriptional regulator
A21D_00738	COG0477	Major facilitator Superfamily
A21D_00742	COG1556	Lactate utilization protein
A21D_00743	COG1139	Iron-sulfur cluster binding protein
A21D_00744	COG0247	lactate metabolic process
A21D_00745	COG2186	Transcriptional regulator
A21D_00746	COG1620	l-lactate permease
A21D_00747	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A21D_00749	COG2132	Multicopper oxidase
A21D_00750	COG0460	homoserine dehydrogenase
A21D_00751	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
A21D_00753	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
A21D_00754	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
A21D_00759	COG1131	(ABC) transporter
A21D_00764	COG0531	amino acid
A21D_00765	COG3250	beta-galactosidase activity
A21D_00768	COG1607	acyl-coa hydrolase
A21D_00769	COG1413	lyase activity
A21D_00771	COG1105	Belongs to the carbohydrate kinase PfkB family
A21D_00772	COG1349	DNA-binding transcription factor activity
A21D_00775	COG1846	Transcriptional regulator
A21D_00776	COG0400	carboxylic ester hydrolase activity
A21D_00778	COG2514	catechol 2,3-dioxygenase activity
A21D_00780	COG0668	transmembrane transport
A21D_00781	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
A21D_00782	COG0535	radical SAM domain protein
A21D_00784	COG1802	Transcriptional regulator
A21D_00785	COG1114	Component of the transport system for branched-chain amino acids
A21D_00787	COG1132	(ABC) transporter
A21D_00788	COG3559	Exporter of polyketide antibiotics
A21D_00789	COG1131	(ABC) transporter
A21D_00792	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A21D_00792	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A21D_00793	COG2972	Histidine kinase
A21D_00793	COG0745	RESPONSE REGULATOR receiver
A21D_00795	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
A21D_00796	COG4988	ABC transporter
A21D_00797	COG1294	oxidase, subunit
A21D_00798	COG1271	oxidase subunit
A21D_00799	COG1714	RDD family
A21D_00800	COG0616	signal peptide processing
A21D_00801	COG0351	phosphomethylpyrimidine kinase
A21D_00804	COG3973	AAA domain
A21D_00807	COG1388	LysM domain
A21D_00810	COG1695	Transcriptional regulator
A21D_00815	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A21D_00820	COG3850	Histidine kinase
A21D_00820	COG5002	protein histidine kinase activity
A21D_00821	COG0745	RESPONSE REGULATOR receiver
A21D_00824	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A21D_00825	COG3064	Membrane
A21D_00826	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
A21D_00827	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
A21D_00828	COG2153	protein acetylation
A21D_00829	COG2084	Dehydrogenase
A21D_00832	COG2226	methyltransferase
A21D_00835	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A21D_00836	COG1105	Belongs to the carbohydrate kinase PfkB family
A21D_00840	COG3716	PTS system mannose fructose sorbose family IID component
A21D_00841	COG3715	PTS system
A21D_00842	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A21D_00843	COG2222	sugar isomerase
A21D_00849	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
A21D_00853	COG0494	nUDIX hydrolase
A21D_00857	COG1316	TRANSCRIPTIONal
A21D_00859	COG1134	teichoic acid transport
A21D_00860	COG1682	transport, permease protein
A21D_00861	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
A21D_00862	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
A21D_00864	COG1316	TRANSCRIPTIONal
A21D_00866	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A21D_00873	COG4193	domain, Protein
A21D_00874	COG1215	transferase activity, transferring glycosyl groups
A21D_00876	COG1134	teichoic acid transport
A21D_00877	COG1682	transport, permease protein
A21D_00878	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
A21D_00879	COG0438	transferase activity, transferring glycosyl groups
A21D_00885	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
A21D_00886	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A21D_00888	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
A21D_00890	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
A21D_00891	COG0095	Lipoate-protein ligase
A21D_00892	COG1737	Transcriptional regulator
A21D_00893	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
A21D_00894	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A21D_00894	COG1263	PTS System
A21D_00894	COG2190	(PTS) system
A21D_00898	COG1447	Phosphotransferase system cellobiose-specific component IIA
A21D_00899	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A21D_00900	COG1486	melibiose metabolic process
A21D_00902	COG3394	polysaccharide catabolic process
A21D_00905	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
A21D_00906	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A21D_00911	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A21D_00913	COG4786	Flagellar basal body rod
A21D_00914	COG4786	Flagellar basal body rod
A21D_00915	COG1077	Cell shape determining protein MreB Mrl
A21D_00916	COG1609	Transcriptional regulator
A21D_00918	COG2385	sporulation resulting in formation of a cellular spore
A21D_00919	COG4608	Belongs to the ABC transporter superfamily
A21D_00920	COG0791	NLP P60 protein
A21D_00921	COG4166	transmembrane transport
A21D_00922	COG0444	Belongs to the ABC transporter superfamily
A21D_00923	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A21D_00924	COG0601	transmembrane transport
A21D_00925	COG2362	D-Aminopeptidase
A21D_00926	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
A21D_00928	COG4836	Membrane
A21D_00929	COG0355	proton-transporting ATP synthase activity, rotational mechanism
A21D_00930	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
A21D_00931	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
A21D_00932	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
A21D_00933	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A21D_00934	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
A21D_00935	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A21D_00936	COG0356	it plays a direct role in the translocation of protons across the membrane
A21D_00938	COG1404	Belongs to the peptidase S8 family
A21D_00939	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
A21D_00940	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
A21D_00942	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
A21D_00943	COG4475	Protein of unknown function (DUF436)
A21D_00944	COG0698	ribose 5-phosphate isomerase
A21D_00945	COG0840	transmembrane signaling receptor activity
A21D_00946	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A21D_00947	COG1971	Probably functions as a manganese efflux pump
A21D_00949	COG0009	L-threonylcarbamoyladenylate synthase
A21D_00952	COG2890	protein-(glutamine-N5) methyltransferase activity
A21D_00953	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
A21D_00954	COG1435	thymidine kinase activity
A21D_00955	COG0254	rRNA binding
A21D_00956	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
A21D_00957	COG1494	fructose-1,6-bisphosphatase
A21D_00958	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
A21D_00959	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
A21D_00960	COG0191	fructose-bisphosphate aldolase activity
A21D_00962	COG0504	CTP synthase activity
A21D_00963	COG3343	RNA polymerase activity
A21D_00964	COG3226	Transcriptional regulator
A21D_00965	COG1960	acyl-CoA dehydrogenase activity
A21D_00966	COG1960	acyl-CoA dehydrogenase activity
A21D_00967	COG1250	3-hydroxyacyl-CoA dehydrogenase
A21D_00968	COG0183	Belongs to the thiolase family
A21D_00969	COG0247	lactate metabolic process
A21D_00969	COG2181	nitrate reductase activity
A21D_00970	COG1882	Formate acetyltransferase
A21D_00971	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
A21D_00972	COG0018	arginyl-trna synthetase
A21D_00974	COG5578	integral membrane protein
A21D_00975	COG0395	ABC-type sugar transport system, permease component
A21D_00976	COG4209	transmembrane transport
A21D_00977	COG1653	transport
A21D_00978	COG1653	transport
A21D_00979	COG0039	L-malate dehydrogenase activity
A21D_00980	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A21D_00982	COG3465	dGTPase activity
A21D_00983	COG1078	dGTPase activity
A21D_00984	COG0095	Lipoate-protein ligase
A21D_00985	COG0280	phosphate acetyltransferase
A21D_00987	COG3773	Cell wall hydrolase
A21D_00990	COG2363	Small membrane protein
A21D_00994	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
A21D_00996	COG3594	Acyltransferase
A21D_00997	COG3459	Glycosyltransferase 36 associated
A21D_01000	COG1175	transmembrane transport
A21D_01001	COG0395	ABC-type sugar transport system, permease component
A21D_01002	COG1609	Transcriptional regulator
A21D_01006	COG1309	transcriptional regulator
A21D_01008	COG1131	(ABC) transporter
A21D_01009	COG1028	Short-chain dehydrogenase reductase Sdr
A21D_01012	COG0789	Transcriptional regulator
A21D_01014	COG1122	ATPase activity
A21D_01015	COG1122	ATPase activity
A21D_01018	COG0318	PFAM AMP-dependent synthetase and ligase
A21D_01019	COG1268	BioY protein
A21D_01020	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
A21D_01021	COG1960	acyl-CoA dehydrogenase activity
A21D_01023	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A21D_01024	COG1280	lysine exporter protein (LysE YggA)
A21D_01025	COG0456	acetyltransferase
A21D_01026	COG1078	dGTPase activity
A21D_01028	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A21D_01031	COG0156	8-amino-7-oxononanoate synthase activity
A21D_01032	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
A21D_01033	COG1424	Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP
A21D_01036	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
A21D_01037	COG2169	Transcriptional regulator
A21D_01038	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A21D_01039	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
A21D_01044	COG1917	Cupin 2, conserved barrel domain protein
A21D_01044	COG2207	Transcriptional regulator
A21D_01045	COG3708	Transcriptional regulator
A21D_01045	COG2207	Transcriptional regulator
A21D_01047	COG0583	DNA-binding transcription factor activity
A21D_01051	COG3739	integral membrane protein
A21D_01052	COG3655	Transcriptional regulator
A21D_01066	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A21D_01069	COG0384	phenazine biosynthesis protein PhzF
A21D_01070	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
A21D_01075	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A21D_01076	COG0698	ribose 5-phosphate isomerase
A21D_01078	COG1349	DNA-binding transcription factor activity
A21D_01082	COG0577	efflux transmembrane transporter activity
A21D_01083	COG5002	protein histidine kinase activity
A21D_01084	COG0745	RESPONSE REGULATOR receiver
A21D_01085	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A21D_01087	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
A21D_01088	COG5662	AntiSigma factor
A21D_01089	COG1595	DNA-templated transcription, initiation
A21D_01092	COG3842	ATPase activity
A21D_01095	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
A21D_01097	COG1796	DNA polymerase
A21D_01097	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
A21D_01100	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
A21D_01124	COG3677	Transposase
A21D_01127	COG2856	Zn peptidase
A21D_01128	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
A21D_01129	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
A21D_01129	COG0646	methionine synthase
A21D_01131	COG1131	(ABC) transporter
A21D_01133	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A21D_01134	COG2217	Heavy metal translocating P-type atpase
A21D_01141	COG5444	nuclease activity
A21D_01154	COG0726	polysaccharide deacetylase
A21D_01155	COG2194	sulfuric ester hydrolase activity
A21D_01157	COG0489	protein tyrosine kinase activity
A21D_01158	COG0860	N-Acetylmuramoyl-L-alanine amidase
A21D_01162	COG1295	ribonuclease BN
A21D_01165	COG4548	von Willebrand factor, type A
A21D_01166	COG0714	Associated with various cellular activities
A21D_01167	COG2130	NADP-dependent
A21D_01168	COG0235	Class ii aldolase
A21D_01169	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
A21D_01170	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
A21D_01172	COG1349	DNA-binding transcription factor activity
A21D_01173	COG1979	alcohol dehydrogenase
A21D_01176	COG0385	Bile acid
A21D_01178	COG1840	ABC-type Fe3 transport system, periplasmic component
A21D_01179	COG3842	ATPase activity
A21D_01180	COG1178	ABC-type Fe3 transport system permease component
A21D_01182	COG0483	inositol monophosphate 1-phosphatase activity
A21D_01183	COG1609	Transcriptional regulator
A21D_01184	COG0492	ferredoxin-NADP+ reductase activity
A21D_01185	COG1120	ATPase activity
A21D_01186	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A21D_01187	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A21D_01188	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A21D_01190	COG4509	Sortase family
A21D_01194	COG5386	Cell surface protein
A21D_01195	COG5386	Cell surface protein
A21D_01196	COG5386	Cell surface protein
A21D_01197	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A21D_01198	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A21D_01201	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
A21D_01205	COG0583	DNA-binding transcription factor activity
A21D_01208	COG0280	phosphate acetyltransferase
A21D_01213	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
A21D_01222	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A21D_01223	COG1120	ATPase activity
A21D_01224	COG0477	Major facilitator Superfamily
A21D_01229	COG1129	ABC transporter
A21D_01232	COG1132	(ABC) transporter
A21D_01233	COG1132	(ABC) transporter
A21D_01236	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
A21D_01237	COG5504	Zn-dependent protease
A21D_01239	COG0577	efflux transmembrane transporter activity
A21D_01240	COG1136	(ABC) transporter
A21D_01241	COG2205	protein histidine kinase activity
A21D_01242	COG0745	RESPONSE REGULATOR receiver
A21D_01264	COG1943	Transposase
A21D_01265	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
A21D_01266	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
A21D_01267	COG0101	tRNA pseudouridine synthase activity
A21D_01268	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
A21D_01269	COG1122	ATPase activity
A21D_01270	COG1122	ATPase activity
A21D_01271	COG0203	ribosomal protein L17
A21D_01272	COG0202	RNA polymerase activity
A21D_01273	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
A21D_01274	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
A21D_01275	COG0257	Belongs to the bacterial ribosomal protein bL36 family
A21D_01276	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
A21D_01277	COG2163	COG2163 Ribosomal protein L14E L6E L27E
A21D_01278	COG0563	adenylate kinase activity
A21D_01279	COG0201	protein transport
A21D_01280	COG0200	Binds to the 23S rRNA
A21D_01281	COG1841	ribosomal large subunit assembly
A21D_01282	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
A21D_01283	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
A21D_01284	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
A21D_01285	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
A21D_01286	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
A21D_01287	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
A21D_01288	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
A21D_01289	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
A21D_01290	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
A21D_01291	COG0255	Belongs to the universal ribosomal protein uL29 family
A21D_01292	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
A21D_01293	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
A21D_01294	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
A21D_01295	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
A21D_01296	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
A21D_01297	COG0089	rRNA binding
A21D_01298	COG0088	Forms part of the polypeptide exit tunnel
A21D_01299	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
A21D_01300	COG0051	transcription antitermination factor activity, RNA binding
A21D_01301	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
A21D_01302	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
A21D_01303	COG0049	tRNA binding
A21D_01304	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
A21D_01305	COG1358	cellular component organization or biogenesis
A21D_01306	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
A21D_01307	COG0085	RNA polymerase activity
A21D_01308	COG2813	Specifically methylates the guanine in position
A21D_01310	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
A21D_01311	COG0081	regulation of translation
A21D_01312	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
A21D_01313	COG0250	Participates in transcription elongation, termination and antitermination
A21D_01314	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
A21D_01315	COG0267	Belongs to the bacterial ribosomal protein bL33 family
A21D_01317	COG3688	RNA-binding protein containing a PIN domain
A21D_01318	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A21D_01320	COG0215	cysteine-tRNA ligase activity
A21D_01321	COG1045	serine acetyltransferase
A21D_01322	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A21D_01324	COG4956	integral membrane protein (PIN domain superfamily)
A21D_01325	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
A21D_01327	COG0542	response to heat
A21D_01328	COG3869	Catalyzes the specific phosphorylation of arginine residues in
A21D_01329	COG3880	PFAM UvrB UvrC protein
A21D_01332	COG1285	pathogenesis
A21D_01349	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
A21D_01350	COG1396	sequence-specific DNA binding
A21D_01351	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
A21D_01352	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
A21D_01353	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
A21D_01354	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
A21D_01356	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
A21D_01357	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
A21D_01358	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A21D_01360	COG0037	tRNA processing
A21D_01361	COG0515	serine threonine protein kinase
A21D_01362	COG2304	oxidoreductase activity
A21D_01363	COG2208	phosphoserine phosphatase activity
A21D_01365	COG1098	S1 RNA binding domain
A21D_01369	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
A21D_01370	COG3956	TIGRFAM MazG family protein
A21D_01371	COG2244	polysaccharide biosynthetic process
A21D_01372	COG2002	toxin-antitoxin pair type II binding
A21D_01373	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
A21D_01375	COG0193	aminoacyl-tRNA hydrolase activity
A21D_01376	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
A21D_01377	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
A21D_01378	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
A21D_01379	COG2088	sporulation resulting in formation of a cellular spore
A21D_01380	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A21D_01381	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
A21D_01383	COG4466	Protein conserved in bacteria
A21D_01385	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
A21D_01387	COG3583	domain protein
A21D_01387	COG3584	3D domain protein
A21D_01388	COG0084	hydrolase, TatD family'
A21D_01390	COG2002	toxin-antitoxin pair type II binding
A21D_01391	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
A21D_01392	COG2827	Endonuclease containing a URI domain
A21D_01393	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
A21D_01394	COG4467	Involved in initiation control of chromosome replication
A21D_01395	COG1774	PSP1 C-terminal conserved region
A21D_01396	COG0470	DNA polymerase III
A21D_01397	COG1728	Protein conserved in bacteria
A21D_01398	COG3870	Protein conserved in bacteria
A21D_01399	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
A21D_01400	COG1982	Orn Lys Arg decarboxylase major
A21D_01404	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
A21D_01405	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
A21D_01406	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
A21D_01407	COG0288	reversible hydration of carbon dioxide
A21D_01408	COG0590	tRNA wobble adenosine to inosine editing
A21D_01409	COG1335	isochorismatase
A21D_01410	COG1388	LysM domain
A21D_01410	COG3858	chitin binding
A21D_01411	COG0693	protein deglycase activity
A21D_01412	COG1959	2 iron, 2 sulfur cluster binding
A21D_01413	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A21D_01413	COG1017	nitric oxide dioxygenase activity
A21D_01418	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A21D_01424	COG1301	dicarboxylic acid transport
A21D_01425	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
A21D_01426	COG1418	mRNA catabolic process
A21D_01430	COG0601	transmembrane transport
A21D_01431	COG4608	Belongs to the ABC transporter superfamily
A21D_01435	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
A21D_01436	COG0745	RESPONSE REGULATOR receiver
A21D_01437	COG5002	protein histidine kinase activity
A21D_01439	COG1876	peptidase activity
A21D_01440	COG4991	sh3 domain protein
A21D_01440	COG3103	Sh3 type 3 domain protein
A21D_01440	COG0860	N-Acetylmuramoyl-L-alanine amidase
A21D_01441	COG1309	transcriptional regulator
A21D_01443	COG1486	melibiose metabolic process
A21D_01444	COG1263	PTS System
A21D_01444	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A21D_01446	COG1737	Transcriptional regulator
A21D_01449	COG1428	Deoxynucleoside kinase
A21D_01450	COG1428	Deoxynucleoside kinase
A21D_01451	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
A21D_01455	COG1464	Belongs to the NlpA lipoprotein family
A21D_01456	COG2011	ABC-type metal ion transport system permease component
A21D_01457	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A21D_01458	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
A21D_01459	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
A21D_01462	COG0517	IMP dehydrogenase activity
A21D_01462	COG0516	GMP reductase activity
A21D_01464	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
A21D_01465	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A21D_01466	COG0187	DNA topoisomerase II activity
A21D_01468	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
A21D_01469	COG2501	S4 domain
A21D_01470	COG0592	DNA-directed DNA polymerase activity
A21D_01471	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
A21D_01472	COG0230	Belongs to the bacterial ribosomal protein bL34 family
A21D_01473	COG0594	ribonuclease P activity
A21D_01474	COG0706	membrane insertase activity
A21D_01475	COG1847	R3H domain protein
A21D_01476	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
A21D_01477	COG0445	tRNA wobble uridine modification
A21D_01478	COG0357	Ribosomal RNA small subunit methyltransferase G
A21D_01479	COG1475	DNA binding
A21D_01480	COG1192	Involved in chromosome partitioning
A21D_01481	COG1475	DNA binding
A21D_01485	COG3949	Membrane
A21D_01486	COG0668	transmembrane transport
A21D_01488	COG4481	Protein conserved in bacteria
A21D_01489	COG0012	GTP binding
A21D_01490	COG0360	Binds together with S18 to 16S ribosomal RNA
A21D_01491	COG0629	single-stranded DNA binding
A21D_01492	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
A21D_01493	COG0725	ABC transporter, periplasmic molybdate-binding protein
A21D_01495	COG4241	membrane
A21D_01496	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
A21D_01497	COG0359	binds to the 23S rRNA
A21D_01498	COG0305	Participates in initiation and elongation during chromosome replication
A21D_01499	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
A21D_01501	COG0745	RESPONSE REGULATOR receiver
A21D_01502	COG5002	protein histidine kinase activity
A21D_01503	COG4863	YycH protein
A21D_01504	COG4853	Protein conserved in bacteria
A21D_01505	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
A21D_01506	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A21D_01508	COG1132	(ABC) transporter
A21D_01509	COG0450	alkyl hydroperoxide reductase
A21D_01511	COG1309	transcriptional regulator
A21D_01512	COG2076	Multidrug Resistance protein
A21D_01513	COG2076	Multidrug Resistance protein
A21D_01514	COG0175	sulfate reduction
A21D_01515	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
A21D_01516	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A21D_01520	COG1587	Uroporphyrinogen-III synthase
A21D_01521	COG2046	Belongs to the sulfate adenylyltransferase family
A21D_01522	COG0471	metal ion transport
A21D_01522	COG3273	potassium ion transport
A21D_01523	COG0529	Catalyzes the synthesis of activated sulfate
A21D_01524	COG0406	alpha-ribazole phosphatase activity
A21D_01525	COG1028	Short-chain dehydrogenase reductase Sdr
A21D_01528	COG2027	D-alanyl-D-alanine carboxypeptidase
A21D_01530	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
A21D_01534	COG1183	phosphatidylcholine synthase activity
A21D_01535	COG0688	phosphatidylethanolamine metabolic process
A21D_01536	COG0586	Pfam SNARE associated Golgi protein
A21D_01544	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
A21D_01555	COG3773	Cell wall hydrolase
A21D_01560	COG0494	nUDIX hydrolase
A21D_01562	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A21D_01575	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
A21D_01580	COG0745	RESPONSE REGULATOR receiver
A21D_01581	COG0642	Histidine kinase
A21D_01594	COG3279	Response regulator of the LytR AlgR family
A21D_01596	COG1794	racemase activity, acting on amino acids and derivatives
A21D_01605	COG0726	polysaccharide deacetylase
A21D_01606	COG3711	transcriptional antiterminator
A21D_01606	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A21D_01608	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A21D_01608	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A21D_01608	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A21D_01609	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
A21D_01610	COG3588	fructose-bisphosphate aldolase
A21D_01611	COG0179	Fumarylacetoacetate (FAA) hydrolase
A21D_01612	COG1131	(ABC) transporter
A21D_01614	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A21D_01615	COG0018	arginyl-trna synthetase
A21D_01617	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
A21D_01619	COG0549	Belongs to the carbamate kinase family
A21D_01620	COG1438	arginine binding
A21D_01621	COG0840	transmembrane signaling receptor activity
A21D_01623	COG0477	Major facilitator Superfamily
A21D_01624	COG1174	glycine betaine transport
A21D_01625	COG1732	Glycine betaine
A21D_01626	COG1174	glycine betaine transport
A21D_01627	COG0517	IMP dehydrogenase activity
A21D_01627	COG1125	glycine betaine transport
A21D_01628	COG1510	regulation of RNA biosynthetic process
A21D_01630	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A21D_01631	COG3711	transcriptional antiterminator
A21D_01631	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A21D_01632	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A21D_01633	COG1447	Phosphotransferase system cellobiose-specific component IIA
A21D_01635	COG1760	l-serine dehydratase
A21D_01636	COG1760	l-serine dehydratase
A21D_01638	COG1760	l-serine dehydratase
A21D_01639	COG1760	l-serine dehydratase
A21D_01640	COG0814	amino acid
A21D_01641	COG1486	melibiose metabolic process
A21D_01642	COG2814	Major facilitator Superfamily
A21D_01643	COG5577	PFAM Coat F domain
A21D_01645	COG1113	amino acid transport
A21D_01646	COG3403	YqcI/YcgG family
A21D_01647	COG1280	lysine exporter protein (LysE YggA)
A21D_01650	COG0546	phosphoglycolate phosphatase activity
A21D_01651	COG2116	formate transmembrane transporter activity
A21D_01652	COG3428	Bacterial PH domain
A21D_01657	COG0583	DNA-binding transcription factor activity
A21D_01659	COG0110	maltose O-acetyltransferase activity
A21D_01661	COG2188	Transcriptional regulator
A21D_01662	COG1482	cell wall glycoprotein biosynthetic process
A21D_01663	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A21D_01663	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
A21D_01666	COG3716	PTS system mannose fructose sorbose family IID component
A21D_01668	COG0471	metal ion transport
A21D_01669	COG4565	transcriptional regulatory protein
A21D_01670	COG3290	protein histidine kinase activity
A21D_01675	COG3627	carbon phosphorus lyase activity
A21D_01676	COG4107	phosphonate C-P lyase system protein PhnK
A21D_01677	COG3454	Phosphonate metabolism
A21D_01678	COG4778	phosphonate C-P lyase system protein PhnL
A21D_01679	COG0613	PHP domain protein
A21D_01681	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
A21D_01682	COG3639	organic phosphonate transmembrane transporter activity
A21D_01683	COG3639	organic phosphonate transmembrane transporter activity
A21D_01685	COG2766	serine protein kinase
A21D_01686	COG2718	Belongs to the UPF0229 family
A21D_01688	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A21D_01689	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A21D_01689	COG1321	iron dependent repressor
A21D_01690	COG1121	(ABC) transporter
A21D_01691	COG0803	Belongs to the bacterial solute-binding protein 9 family
A21D_01692	COG2719	SpoVR family
A21D_01694	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
A21D_01695	COG3949	Membrane
A21D_01697	COG4536	flavin adenine dinucleotide binding
A21D_01698	COG1937	Protein conserved in bacteria
A21D_01699	COG0640	Transcriptional regulator
A21D_01700	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
A21D_01701	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A21D_01702	COG5002	protein histidine kinase activity
A21D_01703	COG0745	RESPONSE REGULATOR receiver
A21D_01704	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A21D_01705	COG0785	Cytochrome C biogenesis protein
A21D_01708	COG0583	DNA-binding transcription factor activity
A21D_01709	COG1607	acyl-coa hydrolase
A21D_01714	COG4821	SIS domain
A21D_01717	COG3711	transcriptional antiterminator
A21D_01718	COG2190	(PTS) system
A21D_01719	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
A21D_01720	COG1131	(ABC) transporter
A21D_01722	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
A21D_01723	COG1131	(ABC) transporter
A21D_01727	COG1609	Transcriptional regulator
A21D_01728	COG1609	Transcriptional regulator
A21D_01729	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
A21D_01730	COG0800	Aldolase
A21D_01731	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
A21D_01734	COG3871	stress protein (general stress protein 26)
A21D_01735	COG1136	(ABC) transporter
A21D_01736	COG0577	efflux transmembrane transporter activity
A21D_01738	COG0346	lactoylglutathione lyase activity
A21D_01740	COG1105	Belongs to the carbohydrate kinase PfkB family
A21D_01741	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A21D_01741	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A21D_01741	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A21D_01742	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A21D_01742	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A21D_01742	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A21D_01743	COG0191	fructose-bisphosphate aldolase activity
A21D_01744	COG0561	phosphatase activity
A21D_01748	COG1063	alcohol dehydrogenase
A21D_01749	COG0840	transmembrane signaling receptor activity
A21D_01750	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A21D_01751	COG0581	inorganic phosphate transmembrane transporter activity
A21D_01752	COG0573	inorganic phosphate transmembrane transporter activity
A21D_01753	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
A21D_01756	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
A21D_01757	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A21D_01761	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
A21D_01766	COG0137	argininosuccinate synthase activity
A21D_01768	COG1346	cytolysis
A21D_01770	COG1252	NADH dehydrogenase
A21D_01772	COG3279	Response regulator of the LytR AlgR family
A21D_01773	COG0427	acetyl-CoA hydrolase
A21D_01774	COG0131	Imidazoleglycerol-phosphate dehydratase
A21D_01774	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
A21D_01775	COG0501	Belongs to the peptidase M48B family
A21D_01776	COG0655	NAD(P)H dehydrogenase (quinone) activity
A21D_01779	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A21D_01780	COG0070	glutamate synthase
A21D_01780	COG0067	glutamate synthase
A21D_01780	COG0069	glutamate synthase activity
A21D_01781	COG0493	'glutamate synthase
A21D_01782	COG0820	rRNA (adenine-C2-)-methyltransferase activity
A21D_01787	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
A21D_01788	COG3383	formate dehydrogenase (NAD+) activity
A21D_01789	COG2323	membrane
A21D_01790	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A21D_01792	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A21D_01795	COG1136	(ABC) transporter
A21D_01798	COG2226	methyltransferase
A21D_01799	COG4991	sh3 domain protein
A21D_01799	COG3103	Sh3 type 3 domain protein
A21D_01799	COG0860	N-Acetylmuramoyl-L-alanine amidase
A21D_01800	COG0655	NAD(P)H dehydrogenase (quinone) activity
A21D_01804	COG4152	abc transporter atp-binding protein
A21D_01805	COG4604	ABC transporter, ATP-binding protein
A21D_01806	COG2188	Transcriptional regulator
A21D_01811	COG2032	superoxide dismutase activity
A21D_01812	COG1070	Carbohydrate kinase
A21D_01813	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
A21D_01814	COG1737	Transcriptional regulator
A21D_01816	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A21D_01816	COG1263	PTS System
A21D_01818	COG2814	Major facilitator Superfamily
A21D_01820	COG1136	(ABC) transporter
A21D_01821	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
A21D_01824	COG2070	2-Nitropropane dioxygenase
A21D_01831	COG0791	NLP P60 protein
A21D_01831	COG0741	lytic transglycosylase activity
A21D_01832	COG0251	oxidation-reduction process
A21D_01834	COG0534	Mate efflux family protein
A21D_01835	COG2814	Major facilitator Superfamily
A21D_01837	COG1388	LysM domain
A21D_01837	COG3584	3D domain protein
A21D_01838	COG1131	(ABC) transporter
A21D_01839	COG0842	Transport permease protein
A21D_01840	COG4585	Histidine kinase
A21D_01841	COG2197	response regulator
A21D_01843	COG0156	8-amino-7-oxononanoate synthase activity
A21D_01844	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A21D_01845	COG0488	(ABC) transporter
A21D_01848	COG2755	lipolytic protein G-D-S-L family
A21D_01850	COG2962	Rard protein
A21D_01851	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A21D_01852	COG1607	acyl-coa hydrolase
A21D_01853	COG1115	amino acid carrier protein
A21D_01854	COG1733	regulation of RNA biosynthetic process
A21D_01855	COG2309	aminopeptidase activity
A21D_01857	COG0514	ATP-dependent DNA helicase (RecQ)
A21D_01859	COG1114	Component of the transport system for branched-chain amino acids
A21D_01863	COG0628	permease
A21D_01864	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A21D_01865	COG0861	Integral membrane protein TerC family
A21D_01870	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
A21D_01871	COG3285	dna ligase
A21D_01871	COG1793	dna ligase
A21D_01872	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
A21D_01874	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A21D_01876	COG0583	DNA-binding transcription factor activity
A21D_01877	COG1028	Short-chain dehydrogenase reductase Sdr
A21D_01879	COG4670	ketone body catabolic process
A21D_01881	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
A21D_01882	COG1595	DNA-templated transcription, initiation
A21D_01884	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
A21D_01885	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
A21D_01886	COG0746	molybdenum cofactor guanylyltransferase activity
A21D_01887	COG0521	Mo-molybdopterin cofactor biosynthetic process
A21D_01888	COG0725	ABC transporter, periplasmic molybdate-binding protein
A21D_01889	COG4149	molybdate abc transporter
A21D_01895	COG1735	metal-dependent hydrolase with the TIM-barrel fold
A21D_01896	COG0626	cystathionine gamma-synthase activity
A21D_01897	COG3457	Alanine racemase
A21D_01898	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
A21D_01899	COG0315	cyclic pyranopterin monophosphate synthase activity
A21D_01904	COG0789	Transcriptional regulator
A21D_01906	COG0662	Cupin 2, conserved barrel domain protein
A21D_01907	COG3634	alkyl hydroperoxide reductase activity
A21D_01908	COG0450	alkyl hydroperoxide reductase
A21D_01909	COG1115	amino acid carrier protein
A21D_01910	COG4187	Peptidase family M20/M25/M40
A21D_01912	COG2723	6-phospho-beta-galactosidase activity
A21D_01913	COG1940	carbohydrate kinase activity
A21D_01915	COG0383	alpha-mannosidase activity
A21D_01916	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A21D_01916	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A21D_01916	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A21D_01917	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A21D_01917	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A21D_01917	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A21D_01918	COG0671	phosphoesterase, PA-phosphatase related
A21D_01920	COG0772	Belongs to the SEDS family
A21D_01921	COG0772	Belongs to the SEDS family
A21D_01923	COG0456	acetyltransferase
A21D_01924	COG0590	tRNA wobble adenosine to inosine editing
A21D_01928	COG3414	Phosphotransferase system galactitol-specific IIB component
A21D_01929	COG3775	system Galactitol-specific IIC component
A21D_01930	COG3711	transcriptional antiterminator
A21D_01930	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A21D_01933	COG0318	PFAM AMP-dependent synthetase and ligase
A21D_01944	COG1028	Short-chain dehydrogenase reductase Sdr
A21D_01945	COG0109	protoheme IX farnesyltransferase activity
A21D_01947	COG1253	flavin adenine dinucleotide binding
A21D_01948	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
A21D_01949	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A21D_01950	COG2226	methyltransferase
A21D_01951	COG1328	CTP reductase activity
A21D_01955	COG1801	Protein of unknown function DUF72
A21D_01957	COG0366	Alpha amylase catalytic
A21D_01958	COG1609	Transcriptional regulator
A21D_01961	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
A21D_01962	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
A21D_01963	COG3766	membrane
A21D_01965	COG1842	Phage shock protein A
A21D_01969	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
A21D_01970	COG1122	ATPase activity
A21D_01971	COG4721	ABC-type cobalt transport system, permease component
A21D_01973	COG0579	oxidoreductase
A21D_01974	COG4565	transcriptional regulatory protein
A21D_01979	COG0706	membrane insertase activity
A21D_01984	COG0833	amino acid
A21D_01985	COG1802	Transcriptional regulator
A21D_01986	COG1802	Transcriptional regulator
A21D_01990	COG0488	(ABC) transporter
A21D_01992	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
A21D_02001	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
A21D_02002	COG1131	(ABC) transporter
A21D_02007	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A21D_02009	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A21D_02010	COG0745	RESPONSE REGULATOR receiver
A21D_02011	COG3850	Histidine kinase
A21D_02011	COG5002	protein histidine kinase activity
A21D_02015	COG0737	Belongs to the 5'-nucleotidase family
A21D_02016	COG3639	organic phosphonate transmembrane transporter activity
A21D_02017	COG3639	organic phosphonate transmembrane transporter activity
A21D_02018	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
A21D_02020	COG1597	lipid kinase activity
A21D_02023	COG1846	Transcriptional regulator
A21D_02028	COG0697	spore germination
A21D_02029	COG0513	Belongs to the DEAD box helicase family
A21D_02030	COG3402	PFAM membrane-flanked domain
A21D_02031	COG3428	Bacterial PH domain
A21D_02033	COG0705	Rhomboid family
A21D_02034	COG0736	holo-[acyl-carrier-protein] synthase activity
A21D_02035	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
A21D_02035	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
A21D_02036	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
A21D_02036	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
A21D_02037	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
A21D_02040	COG2337	Toxic component of a toxin-antitoxin (TA) module
A21D_02041	COG1366	Belongs to the anti-sigma-factor antagonist family
A21D_02042	COG1366	Belongs to the anti-sigma-factor antagonist family
A21D_02043	COG2172	sigma factor antagonist activity
A21D_02044	COG2208	phosphoserine phosphatase activity
A21D_02045	COG1366	Belongs to the anti-sigma-factor antagonist family
A21D_02046	COG2172	sigma factor antagonist activity
A21D_02047	COG1191	sigma factor activity
A21D_02048	COG2208	phosphoserine phosphatase activity
A21D_02049	COG2183	response to ionizing radiation
A21D_02050	COG0753	catalase activity
A21D_02051	COG3091	SprT-like family
A21D_02069	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
A21D_02070	COG0802	atpase or kinase
A21D_02071	COG1214	PFAM Peptidase M22, glycoprotease
A21D_02072	COG0456	acetyltransferase
A21D_02073	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
A21D_02074	COG0772	Belongs to the SEDS family
A21D_02075	COG0488	(ABC) transporter
A21D_02076	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
A21D_02078	COG1266	CAAX protease self-immunity
A21D_02079	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
A21D_02080	COG0459	protein refolding
A21D_02081	COG0582	viral genome integration into host DNA
A21D_02083	COG2856	Zn peptidase
A21D_02095	COG5377	YqaJ viral recombinase family
A21D_02096	COG3723	Recombinational DNA repair protein, rece pathway
A21D_02100	COG3331	DNA recombination
A21D_02113	COG3728	DNA packaging
A21D_02113	COG5484	DNA packaging
A21D_02114	COG1783	phage Terminase large subunit
A21D_02115	COG5518	Phage portal protein
A21D_02116	COG2369	cell adhesion
A21D_02118	COG0338	D12 class N6 adenine-specific DNA methyltransferase
A21D_02119	COG4653	Phage capsid family
A21D_02130	COG3953	SLT domain
A21D_02130	COG5280	Phage tail tape measure protein TP901
A21D_02130	COG3953	SLT domain
A21D_02130	COG5280	Phage tail tape measure protein TP901
A21D_02131	COG1652	LysM domain
A21D_02132	COG4193	domain, Protein
A21D_02134	COG3628	GPW Gp25 family protein
A21D_02135	COG3299	homolog of phage Mu protein gp47
A21D_02140	COG4824	toxin secretion phage lysis holin
A21D_02141	COG3409	Peptidoglycan-binding domain 1 protein
A21D_02141	COG5632	N-Acetylmuramoyl-L-alanine amidase
A21D_02147	COG0464	growth
A21D_02152	COG4974	Belongs to the 'phage' integrase family
A21D_02156	COG1115	amino acid carrier protein
A21D_02157	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A21D_02162	COG1966	Carbon starvation protein
A21D_02164	COG0747	negative chemotaxis
A21D_02166	COG4608	Belongs to the ABC transporter superfamily
A21D_02167	COG0444	Belongs to the ABC transporter superfamily
A21D_02170	COG0747	negative chemotaxis
A21D_02172	COG1609	Transcriptional regulator
A21D_02173	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A21D_02174	COG1869	D-ribose catabolic process
A21D_02175	COG1129	ABC transporter
A21D_02176	COG1172	Belongs to the binding-protein-dependent transport system permease family
A21D_02177	COG1879	ABC-type sugar transport system periplasmic component
A21D_02179	COG1473	amidohydrolase
A21D_02180	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
A21D_02181	COG1473	amidohydrolase
A21D_02182	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
A21D_02183	COG1757	Na H antiporter
A21D_02185	COG0561	phosphatase activity
A21D_02186	COG2723	6-phospho-beta-galactosidase activity
A21D_02187	COG2190	(PTS) system
A21D_02187	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A21D_02187	COG1263	PTS System
A21D_02190	COG1442	glycosyl transferase family 8
A21D_02191	COG0071	Belongs to the small heat shock protein (HSP20) family
A21D_02193	COG1454	alcohol dehydrogenase
A21D_02195	COG1510	regulation of RNA biosynthetic process
A21D_02197	COG2200	EAL domain
A21D_02199	COG0840	transmembrane signaling receptor activity
A21D_02200	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A21D_02201	COG0601	transmembrane transport
A21D_02203	COG4608	Belongs to the ABC transporter superfamily
A21D_02204	COG0444	Belongs to the ABC transporter superfamily
A21D_02207	COG0697	spore germination
A21D_02208	COG0531	amino acid
A21D_02211	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
A21D_02212	COG0714	Associated with various cellular activities
A21D_02213	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
A21D_02214	COG1305	Transglutaminase-like
A21D_02215	COG0519	Catalyzes the synthesis of GMP from XMP
A21D_02215	COG0518	GMP synthase (glutamine-hydrolyzing) activity
A21D_02216	COG2217	Heavy metal translocating P-type atpase
A21D_02217	COG0640	Transcriptional regulator
A21D_02218	COG0803	Belongs to the bacterial solute-binding protein 9 family
A21D_02219	COG2252	PERMEase
A21D_02222	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A21D_02223	COG2258	MOSC domain
A21D_02225	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
A21D_02226	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
A21D_02227	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
A21D_02228	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
A21D_02229	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
A21D_02230	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A21D_02231	COG0047	phosphoribosylformylglycinamidine synthase activity
A21D_02232	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A21D_02233	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
A21D_02234	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
A21D_02235	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
A21D_02236	COG0138	bifunctional purine biosynthesis protein purh
A21D_02237	COG0151	Belongs to the GarS family
A21D_02238	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
A21D_02239	COG1470	cell adhesion involved in biofilm formation
A21D_02240	COG4496	protein, YerC YecD
A21D_02241	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
A21D_02242	COG0210	DNA helicase
A21D_02243	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
A21D_02244	COG4851	CamS sex pheromone cAM373 precursor
A21D_02248	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A21D_02249	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A21D_02250	COG0154	amidase activity
A21D_02251	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A21D_02252	COG1597	lipid kinase activity
A21D_02254	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A21D_02257	COG0583	DNA-binding transcription factor activity
A21D_02259	COG1960	acyl-CoA dehydrogenase activity
A21D_02260	COG0372	Belongs to the citrate synthase family
A21D_02261	COG0730	response to heat
A21D_02262	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
A21D_02263	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A21D_02266	COG3655	Transcriptional regulator
A21D_02267	COG0702	epimerase
A21D_02268	COG0531	amino acid
A21D_02270	COG0351	phosphomethylpyrimidine kinase
A21D_02272	COG4496	protein, YerC YecD
A21D_02275	COG1695	Transcriptional regulator
A21D_02279	COG0626	cystathionine gamma-synthase activity
A21D_02280	COG3546	catalase activity
A21D_02282	COG0583	DNA-binding transcription factor activity
A21D_02283	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
A21D_02285	COG2814	Major facilitator Superfamily
A21D_02286	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
A21D_02287	COG2610	gluconate transmembrane transporter activity
A21D_02289	COG0583	DNA-binding transcription factor activity
A21D_02290	COG0372	Belongs to the citrate synthase family
A21D_02291	COG2079	MmgE PrpD family protein
A21D_02292	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
A21D_02295	COG3933	PFAM sigma-54 factor interaction domain-containing protein
A21D_02295	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
A21D_02298	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A21D_02299	COG1447	Phosphotransferase system cellobiose-specific component IIA
A21D_02301	COG1695	Transcriptional regulator
A21D_02303	COG1619	proteins homologs of microcin C7 resistance protein MccF
A21D_02304	COG0166	Belongs to the GPI family
A21D_02305	COG1012	belongs to the aldehyde dehydrogenase family
A21D_02307	COG3835	regulator
A21D_02308	COG0277	FAD linked oxidase domain protein
A21D_02309	COG0247	lactate metabolic process
A21D_02310	COG1937	Protein conserved in bacteria
A21D_02311	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A21D_02313	COG2210	Belongs to the sulfur carrier protein TusA family
A21D_02314	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A21D_02315	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A21D_02315	COG0425	Belongs to the sulfur carrier protein TusA family
A21D_02316	COG2210	Belongs to the sulfur carrier protein TusA family
A21D_02317	COG0425	Belongs to the sulfur carrier protein TusA family
A21D_02319	COG0288	reversible hydration of carbon dioxide
A21D_02320	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A21D_02320	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A21D_02321	COG0840	transmembrane signaling receptor activity
A21D_02323	COG0307	riboflavin synthase, alpha
A21D_02327	COG0488	(ABC) transporter
A21D_02334	COG0446	pyridine nucleotide-disulphide oxidoreductase
A21D_02335	COG0733	neurotransmitter:sodium symporter activity
A21D_02337	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
A21D_02338	COG3844	kynureninase activity
A21D_02339	COG1757	Na H antiporter
A21D_02340	COG0436	Aminotransferase
A21D_02341	COG0028	Belongs to the TPP enzyme family
A21D_02342	COG1012	belongs to the aldehyde dehydrogenase family
A21D_02346	COG1012	belongs to the aldehyde dehydrogenase family
A21D_02347	COG1960	acyl-CoA dehydrogenase activity
A21D_02348	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A21D_02349	COG1077	Cell shape determining protein MreB Mrl
A21D_02350	COG2340	Cysteine-rich secretory protein family
A21D_02352	COG2066	Belongs to the glutaminase family
A21D_02353	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A21D_02355	COG1295	ribonuclease BN
A21D_02356	COG2217	Heavy metal translocating P-type atpase
A21D_02357	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A21D_02358	COG0765	amino acid transport
A21D_02361	COG0477	Major facilitator Superfamily
A21D_02364	COG2056	Na+-H+ antiporter family
A21D_02366	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A21D_02367	COG0542	response to heat
A21D_02371	COG1725	Transcriptional regulator
A21D_02372	COG1131	(ABC) transporter
A21D_02374	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
A21D_02375	COG1131	(ABC) transporter
A21D_02376	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A21D_02378	COG1725	Transcriptional regulator
A21D_02379	COG1396	sequence-specific DNA binding
A21D_02381	COG1090	epimerase
A21D_02382	COG2137	regulation of response to DNA damage stimulus
A21D_02384	COG1988	membrane-bound metal-dependent
A21D_02385	COG1194	a g-specific adenine glycosylase
A21D_02388	COG3557	Belongs to the UPF0374 family
A21D_02389	COG1132	(ABC) transporter
A21D_02391	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
A21D_02392	COG0577	efflux transmembrane transporter activity
A21D_02393	COG1136	(ABC) transporter
A21D_02394	COG2205	protein histidine kinase activity
A21D_02395	COG0745	RESPONSE REGULATOR receiver
A21D_02397	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
A21D_02398	COG2096	Adenosyltransferase
A21D_02399	COG0735	belongs to the Fur family
A21D_02420	COG1943	Transposase
A21D_02421	COG2801	Transposase and inactivated derivatives
A21D_02423	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
A21D_02427	COG4533	DNA binding
A21D_02431	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
A21D_02435	COG1509	lysine 2,3-aminomutase activity
A21D_02437	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
A21D_02442	COG1408	metallophosphoesterase
A21D_02444	COG0384	phenazine biosynthesis protein PhzF
A21D_02446	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
A21D_02447	COG0402	S-adenosylhomocysteine deaminase activity
A21D_02448	COG3775	system Galactitol-specific IIC component
A21D_02449	COG3414	Phosphotransferase system galactitol-specific IIB component
A21D_02450	COG1999	signal sequence binding
A21D_02451	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A21D_02454	COG0352	thiamine-phosphate diphosphorylase activity
A21D_02455	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A21D_02457	COG2022	thiamine diphosphate biosynthetic process
A21D_02458	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A21D_02460	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
A21D_02461	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
A21D_02462	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
A21D_02462	COG1918	ferrous iron import across plasma membrane
A21D_02465	COG5002	protein histidine kinase activity
A21D_02466	COG0745	RESPONSE REGULATOR receiver
A21D_02471	COG0686	Belongs to the AlaDH PNT family
A21D_02472	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
A21D_02473	COG0583	DNA-binding transcription factor activity
A21D_02475	COG3764	Sortase (surface protein transpeptidase)
A21D_02476	COG0436	Aminotransferase
A21D_02477	COG1309	transcriptional regulator
A21D_02480	COG0183	Belongs to the thiolase family
A21D_02482	COG0318	PFAM AMP-dependent synthetase and ligase
A21D_02483	COG0318	PFAM AMP-dependent synthetase and ligase
A21D_02488	COG2233	PERMEase
A21D_02489	COG0402	S-adenosylhomocysteine deaminase activity
A21D_02492	COG1063	alcohol dehydrogenase
A21D_02493	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A21D_02495	COG2706	6-phosphogluconolactonase activity
A21D_02496	COG0028	Belongs to the TPP enzyme family
A21D_02505	COG1735	metal-dependent hydrolase with the TIM-barrel fold
A21D_02507	COG4821	SIS domain
A21D_02508	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A21D_02509	COG1737	Transcriptional regulator
A21D_02510	COG1234	tRNA 3'-trailer cleavage
A21D_02514	COG0444	Belongs to the ABC transporter superfamily
A21D_02515	COG4608	Belongs to the ABC transporter superfamily
A21D_02516	COG2814	Major facilitator Superfamily
A21D_02517	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
A21D_02519	COG1473	amidohydrolase
A21D_02520	COG1288	antiporter activity
A21D_02522	COG4948	Mandelate Racemase Muconate Lactonizing
A21D_02524	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
A21D_02525	COG3711	transcriptional antiterminator
A21D_02526	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A21D_02526	COG2190	(PTS) system
A21D_02526	COG1263	PTS System
A21D_02527	COG1486	melibiose metabolic process
A21D_02528	COG1012	belongs to the aldehyde dehydrogenase family
A21D_02529	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A21D_02530	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A21D_02531	COG1447	Phosphotransferase system cellobiose-specific component IIA
A21D_02532	COG2723	6-phospho-beta-galactosidase activity
A21D_02533	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A21D_02533	COG3711	transcriptional antiterminator
A21D_02534	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A21D_02534	COG3711	transcriptional antiterminator
A21D_02535	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A21D_02535	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A21D_02535	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A21D_02536	COG1482	cell wall glycoprotein biosynthetic process
A21D_02538	COG0656	L-ascorbic acid biosynthetic process
A21D_02541	COG0326	Molecular chaperone. Has ATPase activity
A21D_02544	COG1116	anion transmembrane transporter activity
A21D_02545	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A21D_02549	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A21D_02550	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
A21D_02553	COG2176	DNA-directed DNA polymerase activity
A21D_02558	COG1960	acyl-CoA dehydrogenase activity
A21D_02560	COG0010	Belongs to the arginase family
A21D_02561	COG1228	amidohydrolase
A21D_02563	COG2986	histidine ammonia-lyase
A21D_02565	COG2070	2-Nitropropane dioxygenase
A21D_02566	COG0318	PFAM AMP-dependent synthetase and ligase
A21D_02567	COG0583	DNA-binding transcription factor activity
A21D_02568	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
A21D_02569	COG1473	amidohydrolase
A21D_02570	COG2365	Tyrosine phosphatase family
A21D_02572	COG3290	protein histidine kinase activity
A21D_02572	COG3829	transcription factor binding
A21D_02574	COG1960	acyl-CoA dehydrogenase activity
A21D_02576	COG1012	belongs to the aldehyde dehydrogenase family
A21D_02578	COG1024	Enoyl-CoA hydratase
A21D_02581	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A21D_02583	COG1263	PTS System
A21D_02583	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A21D_02583	COG2190	(PTS) system
A21D_02585	COG0366	Alpha amylase catalytic
A21D_02588	COG1012	belongs to the aldehyde dehydrogenase family
A21D_02589	COG0506	proline dehydrogenase activity
A21D_02592	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A21D_02593	COG2233	PERMEase
A21D_02594	COG2814	Major facilitator Superfamily
A21D_02596	COG0604	alcohol dehydrogenase
A21D_02599	COG4585	Histidine kinase
A21D_02600	COG2197	response regulator
A21D_02601	COG1131	(ABC) transporter
A21D_02607	COG0505	Belongs to the CarA family
A21D_02609	COG1506	peptidase
A21D_02609	COG0823	Involved in the tonB-independent uptake of proteins
A21D_02609	COG4946	Tricorn protease homolog
A21D_02610	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A21D_02617	COG0567	Dehydrogenase, E1 component
A21D_02618	COG0508	dehydrogenase complex catalyzes the overall conversion of
A21D_02619	COG3344	reverse transcriptase
A21D_02620	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A21D_02621	COG0534	Mate efflux family protein
A21D_02622	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
A21D_02624	COG1132	(ABC) transporter
A21D_02625	COG1132	(ABC) transporter
A21D_02626	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A21D_02627	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A21D_02630	COG1191	sigma factor activity
A21D_02635	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A21D_02636	COG1028	Short-chain dehydrogenase reductase Sdr
A21D_02638	COG0024	Methionine aminopeptidase
A21D_02644	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
A21D_02649	COG2270	Major facilitator Superfamily
A21D_02651	COG0114	fumarate hydratase activity
A21D_02653	COG3842	ATPase activity
A21D_02654	COG2508	Transcriptional regulator
A21D_02655	COG3679	Belongs to the UPF0342 family
A21D_02656	COG1024	Enoyl-CoA hydratase
A21D_02660	COG4152	abc transporter atp-binding protein
A21D_02661	COG1668	transmembrane transport
A21D_02662	COG0420	3'-5' exonuclease activity
A21D_02663	COG4717	serine-type aminopeptidase activity
A21D_02664	COG1510	regulation of RNA biosynthetic process
A21D_02667	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A21D_02671	COG1510	regulation of RNA biosynthetic process
A21D_02672	COG0517	IMP dehydrogenase activity
A21D_02672	COG4175	Glycine betaine
A21D_02678	COG0537	adenosine 5'-monophosphoramidase activity
A21D_02680	COG3069	C4-dicarboxylate transmembrane transporter activity
A21D_02682	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A21D_02683	COG1131	(ABC) transporter
A21D_02684	COG4473	ABC transporter
A21D_02685	COG1473	amidohydrolase
A21D_02688	COG2814	Major facilitator Superfamily
A21D_02690	COG4585	Histidine kinase
A21D_02691	COG2197	response regulator
A21D_02692	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
A21D_02693	COG0492	ferredoxin-NADP+ reductase activity
A21D_02693	COG3118	belongs to the thioredoxin family
A21D_02696	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A21D_02697	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
A21D_02700	COG1164	Oligoendopeptidase f
A21D_02702	COG0095	Lipoate-protein ligase
A21D_02703	COG0318	PFAM AMP-dependent synthetase and ligase
A21D_02707	COG0398	Pfam SNARE associated Golgi protein
A21D_02709	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
A21D_02710	COG1074	ATP-dependent DNA helicase activity
A21D_02718	COG2311	Membrane
A21D_02719	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A21D_02723	COG1307	EDD domain protein, DegV family
A21D_02724	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A21D_02729	COG0561	phosphatase activity
A21D_02730	COG1073	alpha beta
A21D_02731	COG2151	metal-sulfur cluster biosynthetic enzyme
A21D_02736	COG1744	ABC transporter substrate-binding protein PnrA-like
A21D_02737	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A21D_02738	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A21D_02741	COG0180	Tryptophanyl-tRNA synthetase
A21D_02742	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
A21D_02746	COG0456	acetyltransferase
A21D_02748	COG1393	Belongs to the ArsC family
A21D_02749	COG4862	establishment of competence for transformation
A21D_02751	COG1164	Oligoendopeptidase f
A21D_02754	COG2346	COG2346, Truncated hemoglobins
A21D_02755	COG4116	CYTH
A21D_02756	COG2357	RelA SpoT domain protein
A21D_02757	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
A21D_02758	COG0564	pseudouridine synthase activity
A21D_02759	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
A21D_02760	COG2239	Acts as a magnesium transporter
A21D_02766	COG2323	membrane
A21D_02767	COG2153	protein acetylation
A21D_02768	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
A21D_02769	COG2382	esterase
A21D_02770	COG1132	(ABC) transporter
A21D_02771	COG1132	(ABC) transporter
A21D_02773	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A21D_02775	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A21D_02776	COG4565	transcriptional regulatory protein
A21D_02777	COG3290	protein histidine kinase activity
A21D_02781	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
A21D_02804	COG0039	L-malate dehydrogenase activity
A21D_02806	COG2972	Histidine kinase
A21D_02806	COG0745	RESPONSE REGULATOR receiver
A21D_02807	COG3279	Response regulator of the LytR AlgR family
A21D_02816	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A21D_02819	COG0159	tryptophan synthase activity
A21D_02820	COG0589	response to stress
A21D_02821	COG3258	Cytochrome c
A21D_02822	COG0730	response to heat
A21D_02823	COG0737	Belongs to the 5'-nucleotidase family
A21D_02825	COG1757	Na H antiporter
A21D_02826	COG0733	neurotransmitter:sodium symporter activity
A21D_02828	COG0739	heme binding
A21D_02830	COG4470	Protein conserved in bacteria
A21D_02833	COG2445	Protein of unknown function DUF86
A21D_02834	COG0647	UMP catabolic process
A21D_02835	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
A21D_02836	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
A21D_02838	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
A21D_02839	COG4837	Protein of unknown function (DUF1462)
A21D_02840	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
A21D_02841	COG0316	Belongs to the HesB IscA family
A21D_02842	COG0492	ferredoxin-NADP+ reductase activity
A21D_02843	COG1252	NADH dehydrogenase
A21D_02845	COG3584	3D domain protein
A21D_02846	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
A21D_02849	COG0813	purine-nucleoside phosphorylase activity
A21D_02850	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
A21D_02853	COG2032	superoxide dismutase activity
A21D_02854	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
A21D_02855	COG0166	Belongs to the GPI family
A21D_02856	COG2155	Conserved Protein
A21D_02857	COG1098	S1 RNA binding domain
A21D_02859	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
A21D_02862	COG4412	M6 family metalloprotease domain protein
A21D_02862	COG1404	Belongs to the peptidase S8 family
A21D_02863	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
A21D_02864	COG3191	aminopeptidase activity
A21D_02865	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
A21D_02866	COG2050	protein possibly involved in aromatic compounds catabolism
A21D_02867	COG1575	Belongs to the MenA family. Type 1 subfamily
A21D_02868	COG1169	isochorismate synthase
A21D_02869	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
A21D_02870	COG0596	Alpha beta hydrolase
A21D_02871	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
A21D_02872	COG0318	PFAM AMP-dependent synthetase and ligase
A21D_02880	COG0494	nUDIX hydrolase
A21D_02881	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A21D_02882	COG1116	anion transmembrane transporter activity
A21D_02883	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A21D_02884	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
A21D_02885	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
A21D_02886	COG0367	asparagine synthase
A21D_02887	COG4990	cell redox homeostasis
A21D_02888	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
A21D_02890	COG1454	alcohol dehydrogenase
A21D_02890	COG1012	belongs to the aldehyde dehydrogenase family
A21D_02891	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
A21D_02892	COG0495	leucyl-tRNA aminoacylation
A21D_02894	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A21D_02900	COG2081	HI0933 family
A21D_02901	COG2244	polysaccharide biosynthetic process
A21D_02902	COG1187	pseudouridine synthase activity
A21D_02905	COG0510	thiamine kinase activity
A21D_02907	COG0220	tRNA (guanine-N7-)-methyltransferase activity
A21D_02908	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A21D_02910	COG1363	Peptidase, m42
A21D_02911	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
A21D_02913	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A21D_02914	COG4848	Belongs to the UPF0354 family
A21D_02915	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A21D_02916	COG1674	ftsk spoiiie
A21D_02918	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A21D_02922	COG0849	cell division
A21D_02923	COG1605	Chorismate mutase
A21D_02923	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
A21D_02925	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
A21D_02927	COG0123	including yeast histone deacetylase and acetoin utilization protein
A21D_02928	COG0517	IMP dehydrogenase activity
A21D_02929	COG0454	-acetyltransferase
A21D_02932	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
A21D_02933	COG2199	diguanylate cyclase activity
A21D_02933	COG2203	Gaf domain
A21D_02934	COG1956	GAF domain-containing protein
A21D_02935	COG1309	transcriptional regulator
A21D_02936	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
A21D_02937	COG1104	cysteine desulfurase activity
A21D_02938	COG0301	tRNA thio-modification
A21D_02940	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
A21D_02942	COG3874	Sporulation protein YtfJ
A21D_02943	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
A21D_02944	COG0827	DNA restriction-modification system
A21D_02945	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
A21D_02948	COG0686	Belongs to the AlaDH PNT family
A21D_02949	COG0006	proline dipeptidase activity
A21D_02950	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
A21D_02951	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
A21D_02953	COG4109	DRTGG domain
A21D_02955	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
A21D_02960	COG0587	DNA-directed DNA polymerase activity
A21D_02961	COG0281	malic enzyme
A21D_02962	COG1725	Transcriptional regulator
A21D_02963	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
A21D_02964	COG0825	malonyl-CoA metabolic process
A21D_02965	COG0205	6-phosphofructokinase activity
A21D_02967	COG3030	protein affecting phage T7 exclusion by the F plasmid
A21D_02968	COG0628	permease
A21D_02969	COG0372	Belongs to the citrate synthase family
A21D_02970	COG0538	isocitrate dehydrogenase activity
A21D_02971	COG0039	L-malate dehydrogenase activity
A21D_02973	COG0745	RESPONSE REGULATOR receiver
A21D_02974	COG5002	protein histidine kinase activity
A21D_02975	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A21D_02975	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A21D_02976	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
A21D_02977	COG0237	dephospho-CoA kinase activity
A21D_02978	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
A21D_02979	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
A21D_02981	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
A21D_02982	COG3611	Membrane attachment protein
A21D_02983	COG1484	DNA-dependent DNA replication
A21D_02985	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
A21D_02986	COG2801	Transposase and inactivated derivatives
A21D_02987	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
A21D_02988	COG0291	Belongs to the bacterial ribosomal protein bL35 family
A21D_02989	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
A21D_02990	COG3326	Membrane
A21D_02991	COG0398	Pfam SNARE associated Golgi protein
A21D_02994	COG1363	Peptidase, m42
A21D_02995	COG0741	lytic transglycosylase activity
A21D_02996	COG1131	(ABC) transporter
A21D_03001	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A21D_03002	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
A21D_03003	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A21D_03003	COG0072	phenylalanine-tRNA ligase activity
A21D_03004	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
A21D_03005	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
A21D_03006	COG1286	toxin biosynthetic process
A21D_03007	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
A21D_03007	COG1796	DNA polymerase
A21D_03008	COG1193	negative regulation of DNA recombination
A21D_03009	COG3766	membrane
A21D_03010	COG0318	PFAM AMP-dependent synthetase and ligase
A21D_03011	COG1309	transcriptional regulator
A21D_03012	COG1024	Enoyl-CoA hydratase
A21D_03013	COG2086	electron transfer activity
A21D_03014	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
A21D_03015	COG3118	belongs to the thioredoxin family
A21D_03016	COG0322	excinuclease ABC activity
A21D_03017	COG1719	4-vinyl reductase, 4VR
A21D_03018	COG2009	succinate dehydrogenase
A21D_03019	COG1053	succinate dehydrogenase
A21D_03020	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
A21D_03021	COG0824	Thioesterase
A21D_03022	COG2197	response regulator
A21D_03025	COG2226	methyltransferase
A21D_03027	COG0640	Transcriptional regulator
A21D_03031	COG1064	alcohol dehydrogenase
A21D_03033	COG1725	Transcriptional regulator
A21D_03046	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A21D_03047	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A21D_03048	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A21D_03051	COG0314	molybdopterin synthase activity
A21D_03052	COG0783	Belongs to the Dps family
A21D_03055	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A21D_03060	COG1846	Transcriptional regulator
A21D_03061	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
A21D_03062	COG5401	PFAM Sporulation and spore germination
A21D_03063	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
A21D_03064	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
A21D_03065	COG0622	Phosphoesterase
A21D_03070	COG0544	peptidyl-prolyl cis-trans isomerase activity
A21D_03071	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
A21D_03073	COG0218	Necessary for normal cell division and for the maintenance of normal septation
A21D_03075	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
A21D_03076	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A21D_03077	COG0181	hydroxymethylbilane synthase activity
A21D_03078	COG1587	Uroporphyrinogen-III synthase
A21D_03079	COG0113	porphobilinogen synthase activity
A21D_03080	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
A21D_03081	COG1388	LysM domain
A21D_03083	COG0525	valine-tRNA ligase activity
A21D_03085	COG0189	ligase activity
A21D_03086	COG0285	dihydrofolate synthase activity
A21D_03088	COG2003	Belongs to the UPF0758 family
A21D_03089	COG1077	Cell shape determining protein MreB Mrl
A21D_03090	COG1792	Involved in formation and maintenance of cell shape
A21D_03092	COG0850	regulation of cytokinetic process
A21D_03093	COG2894	cell division
A21D_03095	COG1994	Peptidase M50
A21D_03096	COG0261	This protein binds to 23S rRNA in the presence of protein L20
A21D_03097	COG2868	ribosomal protein
A21D_03098	COG0211	Belongs to the bacterial ribosomal protein bL27 family
A21D_03100	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
A21D_03101	COG0077	Prephenate dehydratase
A21D_03103	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
A21D_03105	COG0217	transcriptional regulatory protein
A21D_03106	COG0632	four-way junction helicase activity
A21D_03107	COG2255	four-way junction helicase activity
A21D_03109	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
A21D_03110	COG0343	queuine tRNA-ribosyltransferase activity
A21D_03111	COG1862	Preprotein translocase
A21D_03113	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
A21D_03114	COG2244	polysaccharide biosynthetic process
A21D_03116	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A21D_03116	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A21D_03117	COG5416	Lipopolysaccharide assembly protein A domain
A21D_03118	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
A21D_03118	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
A21D_03119	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A21D_03120	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A21D_03121	COG1490	D-aminoacyl-tRNA deacylase activity
A21D_03122	COG4991	sh3 domain protein
A21D_03122	COG3103	Sh3 type 3 domain protein
A21D_03122	COG0860	N-Acetylmuramoyl-L-alanine amidase
A21D_03124	COG0124	histidyl-tRNA synthetase
A21D_03125	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
A21D_03127	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
A21D_03128	COG1959	2 iron, 2 sulfur cluster binding
A21D_03129	COG1104	cysteine desulfurase activity
A21D_03130	COG0482	sulfurtransferase activity
A21D_03132	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A21D_03134	COG0628	permease
A21D_03135	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A21D_03136	COG4472	Bacterial protein of unknown function (DUF965)
A21D_03137	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
A21D_03138	COG3906	Belongs to the UPF0473 family
A21D_03139	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
A21D_03141	COG0572	uridine kinase
A21D_03142	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A21D_03144	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
A21D_03147	COG1191	sigma factor activity
A21D_03149	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A21D_03149	COG1263	PTS System
A21D_03152	COG2212	antiporter activity
A21D_03154	COG0651	ATP synthesis coupled electron transport
A21D_03155	COG1006	Multisubunit Na H antiporter MnhC subunit
A21D_03156	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
A21D_03156	COG2111	Na H antiporter
A21D_03159	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
A21D_03160	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
A21D_03161	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
A21D_03162	COG1534	Rna-binding protein
A21D_03163	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
A21D_03164	COG1713	HD superfamily hydrolase involved in NAD metabolism
A21D_03165	COG0799	negative regulation of ribosome biogenesis
A21D_03167	COG1596	polysaccharide export
A21D_03167	COG1555	photosystem II stabilization
A21D_03168	COG2131	deaminase
A21D_03169	COG0658	competence protein
A21D_03169	COG2333	competence protein COMEC
A21D_03171	COG1466	dna polymerase III delta subunit
A21D_03172	COG0268	Binds directly to 16S ribosomal RNA
A21D_03173	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
A21D_03174	COG0860	N-Acetylmuramoyl-L-alanine amidase
A21D_03176	COG0481	GTPase activity
A21D_03177	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A21D_03178	COG1420	regulation of RNA biosynthetic process
A21D_03179	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
A21D_03180	COG0443	Heat shock 70 kDa protein
A21D_03181	COG0484	heat shock protein binding
A21D_03182	COG2264	protein methyltransferase activity
A21D_03183	COG1385	rRNA (uridine-N3-)-methyltransferase activity
A21D_03184	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A21D_03185	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
A21D_03186	COG0828	Belongs to the bacterial ribosomal protein bS21 family
A21D_03187	COG1610	YqeY-like protein
A21D_03188	COG1030	water channel activity
A21D_03189	COG4864	UPF0365 protein
A21D_03193	COG1702	phosphate starvation-inducible protein PhoH
A21D_03194	COG1480	7TM receptor with intracellular HD hydrolase
A21D_03195	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
A21D_03197	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
A21D_03199	COG1381	Involved in DNA repair and RecF pathway recombination
A21D_03200	COG0752	glycyl-tRNA synthetase alpha subunit
A21D_03201	COG0751	glycine-tRNA ligase activity
A21D_03202	COG0517	IMP dehydrogenase activity
A21D_03203	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
A21D_03204	COG0358	DNA primase activity
A21D_03205	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A21D_03207	COG2384	SAM-dependent methyltransferase
A21D_03208	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
A21D_03214	COG1030	water channel activity
A21D_03215	COG0704	Plays a role in the regulation of phosphate uptake
A21D_03222	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
A21D_03223	COG0477	Major facilitator Superfamily
A21D_03225	COG0704	Plays a role in the regulation of phosphate uptake
A21D_03228	COG0267	Belongs to the bacterial ribosomal protein bL33 family
A21D_03229	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
A21D_03231	COG0457	Tetratricopeptide repeat
A21D_03231	COG0705	Rhomboid family
A21D_03234	COG0697	spore germination
A21D_03236	COG1940	carbohydrate kinase activity
A21D_03237	COG1368	sulfuric ester hydrolase activity
A21D_03240	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A21D_03248	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
A21D_03251	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
A21D_03252	COG0404	The glycine cleavage system catalyzes the degradation of glycine
A21D_03253	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
A21D_03254	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
A21D_03255	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A21D_03256	COG1321	iron dependent repressor
A21D_03257	COG1752	Esterase of the alpha-beta hydrolase superfamily
A21D_03260	COG0006	proline dipeptidase activity
A21D_03261	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
A21D_03262	COG3854	ATPases associated with a variety of cellular activities
A21D_03270	COG0511	ligase activity, forming carbon-carbon bonds
A21D_03271	COG0439	Biotin carboxylase
A21D_03272	COG1302	Protein conserved in bacteria
A21D_03273	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A21D_03274	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
A21D_03275	COG1570	exodeoxyribonuclease VII activity
A21D_03276	COG1722	exodeoxyribonuclease VII activity
A21D_03277	COG0142	geranyltranstransferase activity
A21D_03279	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
A21D_03280	COG1438	arginine binding
A21D_03281	COG0497	DNA recombination
A21D_03282	COG0750	zinc metalloprotease
A21D_03284	COG0527	aspartate kinase activity
A21D_03286	COG3290	protein histidine kinase activity
A21D_03286	COG3829	transcription factor binding
A21D_03287	COG0280	phosphate acetyltransferase
A21D_03289	COG3426	butyrate kinase activity
A21D_03290	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A21D_03291	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
A21D_03292	COG0022	dehydrogenase e1 component
A21D_03293	COG0508	dehydrogenase complex catalyzes the overall conversion of
A21D_03295	COG4129	membrane
A21D_03298	COG0346	lactoylglutathione lyase activity
A21D_03299	COG2195	Cleaves the N-terminal amino acid of tripeptides
A21D_03300	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A21D_03302	COG1012	belongs to the aldehyde dehydrogenase family
A21D_03303	COG1234	tRNA 3'-trailer cleavage
A21D_03304	COG0584	glycerophosphoryl diester phosphodiesterase
A21D_03305	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A21D_03306	COG0300	oxidoreductase activity
A21D_03308	COG0667	Aldo Keto reductase
A21D_03310	COG1379	DNA repair
A21D_03311	COG1300	Membrane
A21D_03312	COG0735	belongs to the Fur family
A21D_03314	COG4974	Belongs to the 'phage' integrase family
A21D_03315	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
A21D_03318	COG1686	Belongs to the peptidase S11 family
A21D_03320	COG2172	sigma factor antagonist activity
A21D_03325	COG0697	spore germination
A21D_03327	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
A21D_03329	COG0456	acetyltransferase
A21D_03331	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
A21D_03332	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
A21D_03333	COG1686	Belongs to the peptidase S11 family
A21D_03334	COG2715	membrane protein required for spore maturation
A21D_03335	COG0700	Nucleoside recognition
A21D_03336	COG1187	pseudouridine synthase activity
A21D_03337	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A21D_03338	COG1333	cytochrome c biogenesis protein
A21D_03339	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A21D_03340	COG0745	RESPONSE REGULATOR receiver
A21D_03341	COG5002	protein histidine kinase activity
A21D_03346	COG0514	ATP-dependent DNA helicase (RecQ)
A21D_03349	COG4862	establishment of competence for transformation
A21D_03350	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
A21D_03351	COG0492	ferredoxin-NADP+ reductase activity
A21D_03353	COG2339	peptidase activity
A21D_03354	COG3409	Peptidoglycan-binding domain 1 protein
A21D_03354	COG3773	Cell wall hydrolase
A21D_03355	COG2959	enzyme of heme biosynthesis
A21D_03357	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
A21D_03359	COG0539	negative regulation of cytoplasmic translation
A21D_03362	COG1160	GTP binding
A21D_03363	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
A21D_03367	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
A21D_03368	COG0776	regulation of translation
A21D_03370	COG0142	geranyltranstransferase activity
A21D_03371	COG2226	methyltransferase
A21D_03372	COG0142	geranyltranstransferase activity
A21D_03373	COG0105	UTP biosynthetic process
A21D_03374	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
A21D_03375	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
A21D_03376	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
A21D_03377	COG4401	Chorismate mutase type I
A21D_03378	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A21D_03379	COG0287	Prephenate dehydrogenase
A21D_03380	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
A21D_03381	COG0457	Tetratricopeptide repeat
A21D_03382	COG5582	Belongs to the UPF0302 family
A21D_03385	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
A21D_03387	COG4347	Protein of unknown function (DUF1405)
A21D_03389	COG2738	Putative neutral zinc metallopeptidase
A21D_03392	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A21D_03393	COG1694	Mazg nucleotide pyrophosphohydrolase
A21D_03394	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
A21D_03395	COG1803	Methylglyoxal synthase
A21D_03396	COG0438	transferase activity, transferring glycosyl groups
A21D_03397	COG0617	tRNA 3'-terminal CCA addition
A21D_03398	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
A21D_03398	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
A21D_03399	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A21D_03399	COG1199	ATP-dependent helicase activity
A21D_03402	COG0436	Aminotransferase
A21D_03403	COG0017	Asparaginyl-tRNA synthetase
A21D_03404	COG3935	DnaD domain protein
A21D_03405	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
A21D_03406	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A21D_03406	COG4499	WXG100 protein secretion system (Wss), protein YukC
A21D_03407	COG3331	DNA recombination
A21D_03413	COG3599	regulation of cell shape
A21D_03414	COG0116	Belongs to the methyltransferase superfamily
A21D_03415	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
A21D_03416	COG3424	synthase
A21D_03417	COG1755	Isoprenylcysteine carboxyl methyltransferase
A21D_03418	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
A21D_03419	COG0659	secondary active sulfate transmembrane transporter activity
A21D_03422	COG1418	mRNA catabolic process
A21D_03424	COG1388	LysM domain
A21D_03424	COG0791	NLP P60 protein
A21D_03425	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
A21D_03426	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
A21D_03427	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A21D_03428	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A21D_03429	COG0805	protein transport
A21D_03430	COG4479	Belongs to the UPF0346 family
A21D_03431	COG1309	transcriptional regulator
A21D_03434	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A21D_03434	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A21D_03437	COG1254	Belongs to the acylphosphatase family
A21D_03438	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A21D_03438	COG0723	plastoquinol--plastocyanin reductase activity
A21D_03442	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A21D_03444	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A21D_03448	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
A21D_03451	COG0390	transport system, permease component
A21D_03452	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A21D_03453	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A21D_03454	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
A21D_03455	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A21D_03456	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
A21D_03457	COG1024	Enoyl-CoA hydratase
A21D_03458	COG0511	ligase activity, forming carbon-carbon bonds
A21D_03459	COG0439	Biotin carboxylase
A21D_03460	COG0318	PFAM AMP-dependent synthetase and ligase
A21D_03461	COG1960	acyl-CoA dehydrogenase activity
A21D_03464	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A21D_03465	COG0187	DNA topoisomerase II activity
A21D_03466	COG1832	CoA-binding protein
A21D_03469	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
A21D_03470	COG1469	GTP cyclohydrolase I activity
A21D_03471	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
A21D_03474	COG0824	Thioesterase
A21D_03476	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A21D_03477	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
A21D_03478	COG4191	Histidine kinase
A21D_03480	COG4846	Membrane protein involved in cytochrome C biogenesis
A21D_03481	COG2201	protein-glutamate methylesterase activity
A21D_03482	COG2111	Na H antiporter
A21D_03483	COG0785	Cytochrome C biogenesis protein
A21D_03484	COG3763	UPF0154 protein
A21D_03488	COG4224	UPF0291 protein
A21D_03489	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
A21D_03490	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
A21D_03492	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
A21D_03493	COG0789	Transcriptional regulator
A21D_03495	COG3546	catalase activity
A21D_03496	COG1404	Belongs to the peptidase S8 family
A21D_03541	COG5377	YqaJ viral recombinase family
A21D_03556	COG3546	catalase activity
A21D_03560	COG0174	glutamine synthetase
A21D_03561	COG0789	Transcriptional regulator
A21D_03562	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
A21D_03563	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
A21D_03564	COG0464	growth
A21D_03565	COG1923	regulation of RNA biosynthetic process
A21D_03566	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
A21D_03567	COG0783	Belongs to the Dps family
A21D_03568	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
A21D_03569	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
A21D_03571	COG4550	Control of competence regulator ComK, YlbF/YmcA
A21D_03572	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A21D_03573	COG2359	stage V sporulation protein S
A21D_03574	COG1692	metallophosphoesterase
A21D_03575	COG1418	mRNA catabolic process
A21D_03576	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
A21D_03577	COG1058	Belongs to the CinA family
A21D_03577	COG1546	Belongs to the CinA family
A21D_03578	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
A21D_03579	COG1426	Protein conserved in bacteria
A21D_03582	COG0300	oxidoreductase activity
A21D_03583	COG0612	Peptidase, M16
A21D_03584	COG0612	Peptidase, M16
A21D_03589	COG2188	Transcriptional regulator
A21D_03590	COG1674	ftsk spoiiie
A21D_03592	COG0740	serine-type endopeptidase activity
A21D_03593	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A21D_03594	COG0527	aspartate kinase activity
A21D_03595	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
A21D_03596	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
A21D_03597	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A21D_03598	COG1873	PFAM PRC-barrel domain
A21D_03599	COG0612	Peptidase, M16
A21D_03600	COG0726	polysaccharide deacetylase
A21D_03601	COG1185	polyribonucleotide nucleotidyltransferase activity
A21D_03602	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
A21D_03603	COG0196	riboflavin kinase activity
A21D_03604	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
A21D_03605	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
A21D_03606	COG1550	Protein conserved in bacteria
A21D_03607	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
A21D_03609	COG2740	Nucleic-acid-binding protein implicated in transcription termination
A21D_03610	COG0195	Participates in both transcription termination and antitermination
A21D_03611	COG0779	Required for maturation of 30S ribosomal subunits
A21D_03612	COG2176	DNA-directed DNA polymerase activity
A21D_03613	COG0750	zinc metalloprotease
A21D_03614	COG4589	Belongs to the CDS family
A21D_03615	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
A21D_03616	COG0233	cytoplasmic translational termination
A21D_03617	COG0528	UMP kinase activity
A21D_03618	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
A21D_03619	COG0052	Belongs to the universal ribosomal protein uS2 family
A21D_03624	COG1191	sigma factor activity
A21D_03625	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
A21D_03626	COG1776	CheC inhibitor of MCP methylation
A21D_03627	COG0835	chemotaxis
A21D_03628	COG2198	Histidine kinase
A21D_03628	COG0643	Histidine kinase
A21D_03629	COG2201	protein-glutamate methylesterase activity
A21D_03630	COG0455	bacterial-type flagellum organization
A21D_03631	COG1419	protein localization to endoplasmic reticulum
A21D_03632	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
A21D_03633	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
A21D_03634	COG1684	flagellar biosynthetic protein fliR
A21D_03635	COG1987	bacterial-type flagellum assembly
A21D_03636	COG1338	Plays a role in the flagellum-specific transport system
A21D_03637	COG3190	flagellar
A21D_03638	COG2201	protein-glutamate methylesterase activity
A21D_03639	COG1776	CheC inhibitor of MCP methylation
A21D_03639	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
A21D_03640	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
A21D_03641	COG1580	Controls the rotational direction of flagella during chemotaxis
A21D_03642	COG1582	Flagellar protein (FlbD)
A21D_03643	COG4786	Flagellar basal body rod
A21D_03644	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
A21D_03645	COG3144	bacterial-type flagellum assembly
A21D_03648	COG1157	protein secretion by the type III secretion system
A21D_03650	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
A21D_03651	COG1766	The M ring may be actively involved in energy transduction
A21D_03652	COG1677	Flagellar hook-basal body complex protein FliE
A21D_03653	COG1558	bacterial-type flagellum-dependent cell motility
A21D_03654	COG1815	bacterial-type flagellum-dependent cell motility
A21D_03655	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
A21D_03656	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
A21D_03657	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
A21D_03658	COG4974	Belongs to the 'phage' integrase family
A21D_03659	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A21D_03660	COG0758	DNA mediated transformation
A21D_03661	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
A21D_03662	COG0045	succinate-CoA ligase (ADP-forming) activity
A21D_03663	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
A21D_03665	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
A21D_03666	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
A21D_03668	COG0335	large ribosomal subunit rRNA binding
A21D_03669	COG0336	Belongs to the RNA methyltransferase TrmD family
A21D_03670	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
A21D_03672	COG1837	Belongs to the UPF0109 family
A21D_03673	COG0228	four-way junction DNA binding
A21D_03674	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
A21D_03675	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
A21D_03677	COG0552	protein localization to endoplasmic reticulum
A21D_03678	COG1196	nuclear chromosome segregation
A21D_03679	COG4840	Belongs to the UPF0435 family
A21D_03680	COG0571	ribonuclease III activity
A21D_03681	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A21D_03682	COG1028	Short-chain dehydrogenase reductase Sdr
A21D_03683	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
A21D_03684	COG0416	fatty acid biosynthetic process
A21D_03685	COG1349	DNA-binding transcription factor activity
A21D_03686	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
A21D_03687	COG1760	l-serine dehydratase
A21D_03688	COG1760	l-serine dehydratase
A21D_03690	COG1461	Dihydroxyacetone kinase
A21D_03691	COG1302	Protein conserved in bacteria
A21D_03692	COG0227	Belongs to the bacterial ribosomal protein bL28 family
A21D_03693	COG1564	THIamine pyrophosphokinase
A21D_03694	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
A21D_03695	COG1162	GTPase activity
A21D_03696	COG0515	serine threonine protein kinase
A21D_03696	COG2815	serine threonine protein kinase
A21D_03697	COG0631	protein serine/threonine phosphatase activity
A21D_03698	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A21D_03698	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A21D_03699	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
A21D_03700	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
A21D_03701	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
A21D_03702	COG1758	RNA polymerase activity
A21D_03703	COG0194	GDP metabolic process
A21D_03704	COG2052	Domain of unknown function (DUF370)
A21D_03705	COG1561	YicC-like family, N-terminal region
A21D_03706	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
A21D_03709	COG1764	response to oxidative stress
A21D_03710	COG0583	DNA-binding transcription factor activity
A21D_03711	COG2226	methyltransferase
A21D_03712	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
A21D_03713	COG0284	orotidine-5'-phosphate decarboxylase activity
A21D_03714	COG0167	dihydroorotate dehydrogenase activity
A21D_03715	COG0543	2 iron, 2 sulfur cluster binding
A21D_03717	COG0505	Belongs to the CarA family
A21D_03718	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
A21D_03719	COG0540	Belongs to the ATCase OTCase family
A21D_03720	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
A21D_03721	COG0564	pseudouridine synthase activity
A21D_03722	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
A21D_03723	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
A21D_03724	COG3599	regulation of cell shape
A21D_03725	COG2302	S4 RNA-binding domain
A21D_03726	COG0762	integral membrane protein
A21D_03727	COG1799	cell septum assembly
A21D_03728	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
A21D_03730	COG1873	PFAM PRC-barrel domain
A21D_03731	COG1191	sigma factor activity
A21D_03732	COG1191	sigma factor activity
A21D_03734	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
A21D_03735	COG0849	cell division
A21D_03736	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
A21D_03737	COG0772	Belongs to the SEDS family
A21D_03738	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
A21D_03739	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A21D_03740	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
A21D_03741	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
A21D_03742	COG0768	penicillin binding
A21D_03744	COG4839	cell division protein FtsL
A21D_03745	COG0275	rRNA processing
A21D_03746	COG2001	Belongs to the MraZ family
A21D_03747	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
A21D_03749	COG0454	-acetyltransferase
A21D_03751	COG0333	Belongs to the bacterial ribosomal protein bL32 family
A21D_03752	COG1399	metal-binding, possibly nucleic acid-binding protein
A21D_03753	COG1323	Belongs to the UPF0348 family
A21D_03754	COG3480	Lon protease (S16) C-terminal proteolytic domain
A21D_03755	COG3314	Sporulation integral membrane protein YlbJ
A21D_03756	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
A21D_03757	COG0742	ribosomal rna small subunit methyltransferase
A21D_03758	COG4471	UPF0298 protein
A21D_03759	COG3679	Belongs to the UPF0342 family
A21D_03762	COG2340	Cysteine-rich secretory protein family
A21D_03765	COG2322	membrane
A21D_03766	COG3336	cytochrome c oxidase
A21D_03768	COG1845	cytochrome c oxidase, subunit III
A21D_03771	COG0109	protoheme IX farnesyltransferase activity
A21D_03772	COG1612	heme a metabolic process
A21D_03773	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
A21D_03774	COG0772	Belongs to the SEDS family
A21D_03775	COG4838	Belongs to the UPF0358 family
A21D_03776	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
A21D_03782	COG0483	inositol monophosphate 1-phosphatase activity
A21D_03785	COG4493	Belongs to the UPF0637 family
A21D_03786	COG4476	Belongs to the UPF0223 family
A21D_03788	COG0726	polysaccharide deacetylase
A21D_03789	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A21D_03793	COG0022	dehydrogenase e1 component
A21D_03796	COG0242	peptide deformylase activity
A21D_03797	COG0561	phosphatase activity
A21D_03799	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
A21D_03800	COG0569	domain protein
A21D_03801	COG1132	(ABC) transporter
A21D_03802	COG1132	(ABC) transporter
A21D_03804	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A21D_03806	COG1473	amidohydrolase
A21D_03807	COG2171	N-acyltransferase activity
A21D_03808	COG0517	IMP dehydrogenase activity
A21D_03809	COG0640	Transcriptional regulator
A21D_03811	COG1408	metallophosphoesterase
A21D_03817	COG0436	Aminotransferase
A21D_03822	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A21D_03824	COG5001	Diguanylate cyclase
A21D_03824	COG3300	MHYT domain
A21D_03825	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A21D_03828	COG0778	Nitroreductase
A21D_03833	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A21D_03836	COG2323	membrane
A21D_03837	COG1301	dicarboxylic acid transport
A21D_03838	COG0604	alcohol dehydrogenase
A21D_03839	COG0003	Pfam Anion-transporting ATPase
A21D_03841	COG1966	Carbon starvation protein
A21D_03842	COG3069	C4-dicarboxylate transmembrane transporter activity
A21D_03847	COG2720	vancomycin resistance protein
A21D_03849	COG1252	NADH dehydrogenase
A21D_03853	COG2027	D-alanyl-D-alanine carboxypeptidase
A21D_03854	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A21D_03855	COG0667	Aldo Keto reductase
A21D_03856	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A21D_03857	COG0419	ATPase involved in DNA repair
A21D_03858	COG0420	3'-5' exonuclease activity
A21D_03859	COG2226	methyltransferase
A21D_03860	COG5504	Zn-dependent protease
A21D_03861	COG2814	Major facilitator Superfamily
A21D_03862	COG1301	dicarboxylic acid transport
A21D_03864	COG0446	pyridine nucleotide-disulphide oxidoreductase
A21D_03866	COG1063	alcohol dehydrogenase
A21D_03888	COG0584	glycerophosphoryl diester phosphodiesterase
A21D_03889	COG0584	glycerophosphoryl diester phosphodiesterase
A21D_03892	COG1175	transmembrane transport
A21D_03895	COG1585	Membrane protein implicated in regulation of membrane protease activity
A21D_03896	COG2268	Band 7 protein
A21D_03901	COG1349	DNA-binding transcription factor activity
A21D_03903	COG2391	methyltransferase activity
A21D_03906	COG0512	Glutamine amidotransferase of anthranilate synthase
A21D_03910	COG1533	DNA photolyase activity
A21D_03912	COG5564	TIM-barrel signal transduction protein
A21D_03914	COG5564	TIM-barrel signal transduction protein
A21D_03917	COG1408	metallophosphoesterase
A21D_03923	COG1228	amidohydrolase
A21D_03929	COG1131	(ABC) transporter
A21D_03932	COG3425	synthase
A21D_03933	COG1366	Belongs to the anti-sigma-factor antagonist family
A21D_03933	COG2202	Pas domain
A21D_03934	COG2329	Antibiotic biosynthesis monooxygenase
A21D_03938	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
A21D_03941	COG0179	Fumarylacetoacetate (FAA) hydrolase
A21D_03942	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A21D_03944	COG1012	belongs to the aldehyde dehydrogenase family
A21D_03947	COG0583	DNA-binding transcription factor activity
A21D_03948	COG0477	Major facilitator Superfamily
A21D_03949	COG0204	Acyl-transferase
A21D_03954	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A21D_03955	COG0431	NADPH-dependent FMN reductase
A21D_03956	COG1368	sulfuric ester hydrolase activity
A21D_03957	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
A21D_03962	COG1295	ribonuclease BN
A21D_03963	COG0501	Belongs to the peptidase M48B family
A21D_03965	COG5002	protein histidine kinase activity
A21D_03965	COG3850	Histidine kinase
A21D_03966	COG0745	RESPONSE REGULATOR receiver
A21D_03968	COG1063	alcohol dehydrogenase
A21D_03971	COG0508	dehydrogenase complex catalyzes the overall conversion of
A21D_03972	COG0022	dehydrogenase e1 component
A21D_03973	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
A21D_03974	COG3284	Transcriptional regulator
A21D_03978	COG2184	nucleotidyltransferase activity
A21D_03987	COG3409	Peptidoglycan-binding domain 1 protein
A21D_03987	COG1388	LysM domain
A21D_03987	COG5632	N-Acetylmuramoyl-L-alanine amidase
A21D_03988	COG4824	toxin secretion phage lysis holin