locus-tag	class	description
KBP50_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
KBP50_00010	COG0592	DNA-directed DNA polymerase activity
KBP50_00015	COG2501	S4 domain
KBP50_00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
KBP50_00030	COG0187	DNA topoisomerase II activity
KBP50_00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
KBP50_00040	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
KBP50_00050	COG0516	GMP reductase activity
KBP50_00050	COG0517	IMP dehydrogenase activity
KBP50_00060	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
KBP50_00065	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
KBP50_00070	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
KBP50_00080	COG2076	Multidrug Resistance protein
KBP50_00085	COG2076	Multidrug Resistance protein
KBP50_00090	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
KBP50_00095	COG2011	ABC-type metal ion transport system permease component
KBP50_00100	COG1464	Belongs to the NlpA lipoprotein family
KBP50_00120	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
KBP50_00125	COG1428	Deoxynucleoside kinase
KBP50_00130	COG1428	Deoxynucleoside kinase
KBP50_00160	COG1735	metal-dependent hydrolase with the TIM-barrel fold
KBP50_00175	COG3959	Transketolase, thiamine diphosphate binding domain
KBP50_00180	COG3958	Transketolase
KBP50_00190	COG1454	alcohol dehydrogenase
KBP50_00205	COG2390	Transcriptional regulator
KBP50_00225	COG1595	DNA-templated transcription, initiation
KBP50_00230	COG1737	Transcriptional regulator
KBP50_00240	COG1263	PTS System
KBP50_00240	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KBP50_00245	COG1486	melibiose metabolic process
KBP50_00250	COG0860	N-Acetylmuramoyl-L-alanine amidase
KBP50_00255	COG1876	peptidase activity
KBP50_00260	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
KBP50_00270	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KBP50_00275	COG0601	transmembrane transport
KBP50_00280	COG0747	negative chemotaxis
KBP50_00285	COG4608	Belongs to the ABC transporter superfamily
KBP50_00290	COG0444	Belongs to the ABC transporter superfamily
KBP50_00300	COG1418	mRNA catabolic process
KBP50_00305	COG2814	Major facilitator Superfamily
KBP50_00310	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
KBP50_00315	COG1301	dicarboxylic acid transport
KBP50_00320	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
KBP50_00335	COG1017	nitric oxide dioxygenase activity
KBP50_00335	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
KBP50_00340	COG1959	2 iron, 2 sulfur cluster binding
KBP50_00345	COG0693	protein deglycase activity
KBP50_00350	COG1388	LysM domain
KBP50_00350	COG3858	chitin binding
KBP50_00355	COG1335	isochorismatase
KBP50_00360	COG0590	tRNA wobble adenosine to inosine editing
KBP50_00370	COG0288	reversible hydration of carbon dioxide
KBP50_00375	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
KBP50_00380	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
KBP50_00385	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
KBP50_00405	COG1982	Orn Lys Arg decarboxylase major
KBP50_00410	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
KBP50_00415	COG3870	Protein conserved in bacteria
KBP50_00420	COG1728	Protein conserved in bacteria
KBP50_00425	COG0470	DNA polymerase III
KBP50_00430	COG1774	PSP1 C-terminal conserved region
KBP50_00435	COG4467	Involved in initiation control of chromosome replication
KBP50_00440	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
KBP50_00445	COG2827	Endonuclease containing a URI domain
KBP50_00450	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
KBP50_00455	COG2002	toxin-antitoxin pair type II binding
KBP50_00465	COG0084	hydrolase, TatD family'
KBP50_00470	COG3584	3D domain protein
KBP50_00470	COG3583	domain protein
KBP50_00480	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
KBP50_00490	COG4466	Protein conserved in bacteria
KBP50_00500	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
KBP50_00505	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
KBP50_00510	COG2088	sporulation resulting in formation of a cellular spore
KBP50_00515	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
KBP50_00520	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
KBP50_00525	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
KBP50_00530	COG0193	aminoacyl-tRNA hydrolase activity
KBP50_00540	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
KBP50_00545	COG2002	toxin-antitoxin pair type II binding
KBP50_00550	COG2244	polysaccharide biosynthetic process
KBP50_00555	COG3956	TIGRFAM MazG family protein
KBP50_00560	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
KBP50_00580	COG1098	S1 RNA binding domain
KBP50_00590	COG2208	phosphoserine phosphatase activity
KBP50_00595	COG2304	oxidoreductase activity
KBP50_00600	COG0515	serine threonine protein kinase
KBP50_00605	COG0037	tRNA processing
KBP50_00610	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
KBP50_00615	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
KBP50_00620	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
KBP50_00625	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
KBP50_00635	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
KBP50_00640	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
KBP50_00645	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
KBP50_00650	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
KBP50_00655	COG1396	sequence-specific DNA binding
KBP50_00660	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
KBP50_00740	COG1285	pathogenesis
KBP50_00750	COG3880	PFAM UvrB UvrC protein
KBP50_00755	COG3869	Catalyzes the specific phosphorylation of arginine residues in
KBP50_00760	COG0542	response to heat
KBP50_00765	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
KBP50_00770	COG4956	integral membrane protein (PIN domain superfamily)
KBP50_00775	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
KBP50_00780	COG1045	serine acetyltransferase
KBP50_00785	COG0215	cysteine-tRNA ligase activity
KBP50_00795	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KBP50_00800	COG3688	RNA-binding protein containing a PIN domain
KBP50_00810	COG0267	Belongs to the bacterial ribosomal protein bL33 family
KBP50_00815	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
KBP50_00820	COG0250	Participates in transcription elongation, termination and antitermination
KBP50_00825	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
KBP50_00830	COG0081	regulation of translation
KBP50_00835	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
KBP50_00840	COG0222	ribosome binding
KBP50_00845	COG2813	Specifically methylates the guanine in position
KBP50_00850	COG0085	RNA polymerase activity
KBP50_00855	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
KBP50_00865	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
KBP50_00870	COG0049	tRNA binding
KBP50_00875	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
KBP50_00880	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
KBP50_00890	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
KBP50_00895	COG0088	Forms part of the polypeptide exit tunnel
KBP50_00900	COG0089	rRNA binding
KBP50_00905	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
KBP50_00910	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
KBP50_00915	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
KBP50_00920	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
KBP50_00925	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
KBP50_00930	COG0255	Belongs to the universal ribosomal protein uL29 family
KBP50_00935	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
KBP50_00940	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
KBP50_00945	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
KBP50_00950	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
KBP50_00955	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
KBP50_00960	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
KBP50_00965	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
KBP50_00970	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
KBP50_00975	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
KBP50_00980	COG1841	ribosomal large subunit assembly
KBP50_00985	COG0200	Binds to the 23S rRNA
KBP50_00990	COG0201	protein transport
KBP50_00995	COG0563	adenylate kinase activity
KBP50_01000	COG2163	COG2163 Ribosomal protein L14E L6E L27E
KBP50_01005	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
KBP50_01010	COG0257	Belongs to the bacterial ribosomal protein bL36 family
KBP50_01015	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
KBP50_01020	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
KBP50_01025	COG0202	RNA polymerase activity
KBP50_01030	COG0203	ribosomal protein L17
KBP50_01035	COG1122	ATPase activity
KBP50_01040	COG1122	ATPase activity
KBP50_01045	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
KBP50_01050	COG0101	tRNA pseudouridine synthase activity
KBP50_01055	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
KBP50_01060	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
KBP50_01075	COG1395	domain, Protein
KBP50_01130	COG3711	transcriptional antiterminator
KBP50_01135	COG2723	6-phospho-beta-galactosidase activity
KBP50_01140	COG2190	(PTS) system
KBP50_01140	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KBP50_01140	COG1263	PTS System
KBP50_01210	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KBP50_01215	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KBP50_01220	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
KBP50_01225	COG1120	ATPase activity
KBP50_01230	COG0492	ferredoxin-NADP+ reductase activity
KBP50_01235	COG1028	Short-chain dehydrogenase reductase Sdr
KBP50_01260	COG1349	DNA-binding transcription factor activity
KBP50_01275	COG1070	Carbohydrate kinase
KBP50_01285	COG2211	Major facilitator Superfamily
KBP50_01295	COG2271	Major facilitator Superfamily
KBP50_01320	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KBP50_01320	COG1263	PTS System
KBP50_01335	COG0385	Bile acid
KBP50_01360	COG1979	alcohol dehydrogenase
KBP50_01365	COG1349	DNA-binding transcription factor activity
KBP50_01380	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
KBP50_01390	COG2130	NADP-dependent
KBP50_01395	COG0714	Associated with various cellular activities
KBP50_01400	COG4548	von Willebrand factor, type A
KBP50_01420	COG1295	ribonuclease BN
KBP50_01440	COG0860	N-Acetylmuramoyl-L-alanine amidase
KBP50_01445	COG0489	protein tyrosine kinase activity
KBP50_01455	COG2194	sulfuric ester hydrolase activity
KBP50_01465	COG0726	polysaccharide deacetylase
KBP50_01510	COG4974	Belongs to the 'phage' integrase family
KBP50_01565	COG2217	Heavy metal translocating P-type atpase
KBP50_01575	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KBP50_01585	COG1131	(ABC) transporter
KBP50_01595	COG0646	methionine synthase
KBP50_01595	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
KBP50_01600	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
KBP50_01605	COG2856	Zn peptidase
KBP50_01620	COG3677	Transposase
KBP50_01630	COG5434	Belongs to the glycosyl hydrolase 28 family
KBP50_01695	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
KBP50_01725	COG1595	DNA-templated transcription, initiation
KBP50_01730	COG5662	AntiSigma factor
KBP50_01735	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
KBP50_01745	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
KBP50_01760	COG1349	DNA-binding transcription factor activity
KBP50_01770	COG0698	ribose 5-phosphate isomerase
KBP50_01810	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
KBP50_01820	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KBP50_01845	COG5002	protein histidine kinase activity
KBP50_01845	COG3850	Histidine kinase
KBP50_01850	COG3344	reverse transcriptase
KBP50_01855	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KBP50_01865	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KBP50_01880	COG1136	(ABC) transporter
KBP50_01885	COG0577	efflux transmembrane transporter activity
KBP50_01890	COG0745	RESPONSE REGULATOR receiver
KBP50_01895	COG2205	protein histidine kinase activity
KBP50_01905	COG2207	Transcriptional regulator
KBP50_01915	COG2124	cytochrome p450
KBP50_01925	COG3655	Transcriptional regulator
KBP50_01930	COG3739	integral membrane protein
KBP50_01965	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
KBP50_01980	COG1596	polysaccharide export
KBP50_01980	COG1555	photosystem II stabilization
KBP50_01985	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
KBP50_01990	COG2188	Transcriptional regulator
KBP50_02010	COG4821	SIS domain
KBP50_02015	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
KBP50_02055	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
KBP50_02060	COG2169	Transcriptional regulator
KBP50_02065	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
KBP50_02085	COG2843	Capsule synthesis protein
KBP50_02110	COG1078	dGTPase activity
KBP50_02115	COG0456	acetyltransferase
KBP50_02120	COG1280	lysine exporter protein (LysE YggA)
KBP50_02130	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KBP50_02135	COG1136	(ABC) transporter
KBP50_02140	COG0577	efflux transmembrane transporter activity
KBP50_02145	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
KBP50_02175	COG1674	ftsk spoiiie
KBP50_02180	COG2946	Replication initiation factor
KBP50_02205	COG2255	four-way junction helicase activity
KBP50_02225	COG0741	lytic transglycosylase activity
KBP50_02225	COG0791	NLP P60 protein
KBP50_02240	COG0596	Alpha beta hydrolase
KBP50_02245	COG3226	Transcriptional regulator
KBP50_02335	COG1028	Short-chain dehydrogenase reductase Sdr
KBP50_02340	COG3189	MarR family transcriptional regulator
KBP50_02355	COG1309	transcriptional regulator
KBP50_02375	COG0395	ABC-type sugar transport system, permease component
KBP50_02380	COG1175	transmembrane transport
KBP50_02395	COG3459	Glycosyltransferase 36 associated
KBP50_02400	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
KBP50_02415	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
KBP50_02420	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
KBP50_02425	COG0746	molybdenum cofactor guanylyltransferase activity
KBP50_02430	COG0521	Mo-molybdopterin cofactor biosynthetic process
KBP50_02435	COG0725	ABC transporter, periplasmic molybdate-binding protein
KBP50_02440	COG4149	molybdate abc transporter
KBP50_02445	COG0315	cyclic pyranopterin monophosphate synthase activity
KBP50_02455	COG2223	nitrite transmembrane transporter activity
KBP50_02460	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
KBP50_02465	COG1140	nitrate reductase beta subunit
KBP50_02470	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
KBP50_02475	COG2181	nitrate reductase activity
KBP50_02480	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
KBP50_02485	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KBP50_02510	COG0456	acetyltransferase
KBP50_02515	COG1136	(ABC) transporter
KBP50_02535	COG0662	Cupin 2, conserved barrel domain protein
KBP50_02540	COG3634	alkyl hydroperoxide reductase activity
KBP50_02545	COG0450	alkyl hydroperoxide reductase
KBP50_02550	COG1115	amino acid carrier protein
KBP50_02555	COG4187	Peptidase family M20/M25/M40
KBP50_02560	COG2205	protein histidine kinase activity
KBP50_02565	COG0745	RESPONSE REGULATOR receiver
KBP50_02570	COG2311	Membrane
KBP50_02585	COG2723	6-phospho-beta-galactosidase activity
KBP50_02590	COG1940	carbohydrate kinase activity
KBP50_02600	COG0383	alpha-mannosidase activity
KBP50_02605	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
KBP50_02610	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KBP50_02610	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KBP50_02610	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
KBP50_02615	COG1131	(ABC) transporter
KBP50_02625	COG1733	regulation of RNA biosynthetic process
KBP50_02635	COG0666	response to abiotic stimulus
KBP50_02640	COG0456	acetyltransferase
KBP50_02645	COG0590	tRNA wobble adenosine to inosine editing
KBP50_02650	COG0318	PFAM AMP-dependent synthetase and ligase
KBP50_02655	COG1395	domain, Protein
KBP50_02690	COG0109	protoheme IX farnesyltransferase activity
KBP50_02695	COG1253	flavin adenine dinucleotide binding
KBP50_02700	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
KBP50_02705	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KBP50_02710	COG2226	methyltransferase
KBP50_02715	COG1328	CTP reductase activity
KBP50_02735	COG1801	Protein of unknown function DUF72
KBP50_02740	COG0395	ABC-type sugar transport system, permease component
KBP50_02745	COG1175	transmembrane transport
KBP50_02750	COG1653	transport
KBP50_02755	COG0366	Alpha amylase catalytic
KBP50_02760	COG1609	Transcriptional regulator
KBP50_02770	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
KBP50_02780	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
KBP50_02790	COG3766	membrane
KBP50_02800	COG1842	Phage shock protein A
KBP50_02810	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
KBP50_02820	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
KBP50_02825	COG1122	ATPase activity
KBP50_02830	COG4721	ABC-type cobalt transport system, permease component
KBP50_02840	COG0579	oxidoreductase
KBP50_02875	COG0833	amino acid
KBP50_02880	COG1802	Transcriptional regulator
KBP50_02915	COG1757	Na H antiporter
KBP50_02925	COG0488	(ABC) transporter
KBP50_02935	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
KBP50_02970	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
KBP50_02975	COG4974	Belongs to the 'phage' integrase family
KBP50_03060	COG1484	DNA-dependent DNA replication
KBP50_03160	COG3728	DNA packaging
KBP50_03160	COG5484	DNA packaging
KBP50_03300	COG2337	Toxic component of a toxin-antitoxin (TA) module
KBP50_03330	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
KBP50_03340	COG1295	ribonuclease BN
KBP50_03355	COG2217	Heavy metal translocating P-type atpase
KBP50_03360	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KBP50_03365	COG0765	amino acid transport
KBP50_03370	COG0477	Major facilitator Superfamily
KBP50_03385	COG2056	Na+-H+ antiporter family
KBP50_03395	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
KBP50_03400	COG0542	response to heat
KBP50_03420	COG1725	Transcriptional regulator
KBP50_03425	COG1131	(ABC) transporter
KBP50_03435	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
KBP50_03440	COG1131	(ABC) transporter
KBP50_03455	COG2188	Transcriptional regulator
KBP50_03470	COG1090	epimerase
KBP50_03475	COG2137	regulation of response to DNA damage stimulus
KBP50_03485	COG1988	membrane-bound metal-dependent
KBP50_03505	COG3557	Belongs to the UPF0374 family
KBP50_03510	COG1132	(ABC) transporter
KBP50_03520	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
KBP50_03525	COG0577	efflux transmembrane transporter activity
KBP50_03530	COG1136	(ABC) transporter
KBP50_03535	COG2205	protein histidine kinase activity
KBP50_03540	COG0745	RESPONSE REGULATOR receiver
KBP50_03550	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
KBP50_03560	COG2096	Adenosyltransferase
KBP50_03565	COG0735	belongs to the Fur family
KBP50_03695	COG1074	ATP-dependent DNA helicase activity
KBP50_03715	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
KBP50_03725	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
KBP50_03770	COG4974	Belongs to the 'phage' integrase family
KBP50_03850	COG0673	inositol 2-dehydrogenase activity
KBP50_03855	COG1082	Xylose isomerase domain protein TIM barrel
KBP50_03870	COG2188	Transcriptional regulator
KBP50_03875	COG1482	cell wall glycoprotein biosynthetic process
KBP50_03895	COG3716	PTS system mannose fructose sorbose family IID component
KBP50_03900	COG0702	epimerase
KBP50_03905	COG0726	polysaccharide deacetylase
KBP50_03910	COG1408	metallophosphoesterase
KBP50_03925	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
KBP50_03930	COG4988	ABC transporter
KBP50_03935	COG1294	oxidase, subunit
KBP50_03940	COG1271	oxidase subunit
KBP50_03950	COG0456	acetyltransferase
KBP50_03950	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
KBP50_03955	COG2364	Membrane
KBP50_03970	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KBP50_03975	COG1227	inorganic diphosphatase activity
KBP50_03980	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KBP50_03985	COG2318	DinB family
KBP50_03995	COG1970	mechanosensitive ion channel activity
KBP50_04015	COG4474	Belongs to the UPF0398 family
KBP50_04045	COG1247	-acetyltransferase
KBP50_04070	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
KBP50_04100	COG2814	Major facilitator Superfamily
KBP50_04105	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
KBP50_04110	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
KBP50_04115	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KBP50_04120	COG0277	FAD linked oxidase domain protein
KBP50_04135	COG0326	Molecular chaperone. Has ATPase activity
KBP50_04140	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
KBP50_04145	COG1011	Hydrolase
KBP50_04155	COG1757	Na H antiporter
KBP50_04160	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
KBP50_04180	COG2176	DNA-directed DNA polymerase activity
KBP50_04195	COG0583	DNA-binding transcription factor activity
KBP50_04200	COG0010	Belongs to the arginase family
KBP50_04205	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
KBP50_04210	COG1228	amidohydrolase
KBP50_04220	COG2986	histidine ammonia-lyase
KBP50_04225	COG2070	2-Nitropropane dioxygenase
KBP50_04230	COG0318	PFAM AMP-dependent synthetase and ligase
KBP50_04235	COG0583	DNA-binding transcription factor activity
KBP50_04240	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
KBP50_04245	COG1473	amidohydrolase
KBP50_04250	COG2365	Tyrosine phosphatase family
KBP50_04255	COG3290	protein histidine kinase activity
KBP50_04255	COG3829	transcription factor binding
KBP50_04260	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
KBP50_04265	COG1960	acyl-CoA dehydrogenase activity
KBP50_04275	COG1012	belongs to the aldehyde dehydrogenase family
KBP50_04280	COG1024	Enoyl-CoA hydratase
KBP50_04285	COG1024	Enoyl-CoA hydratase
KBP50_04300	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
KBP50_04310	COG2190	(PTS) system
KBP50_04310	COG1263	PTS System
KBP50_04310	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KBP50_04320	COG0366	Alpha amylase catalytic
KBP50_04335	COG1012	belongs to the aldehyde dehydrogenase family
KBP50_04340	COG0506	proline dehydrogenase activity
KBP50_04355	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
KBP50_04360	COG2233	PERMEase
KBP50_04365	COG2814	Major facilitator Superfamily
KBP50_04390	COG4585	Histidine kinase
KBP50_04395	COG2197	response regulator
KBP50_04400	COG1131	(ABC) transporter
KBP50_04425	COG0505	Belongs to the CarA family
KBP50_04430	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
KBP50_04435	COG0823	Involved in the tonB-independent uptake of proteins
KBP50_04435	COG4946	Tricorn protease homolog
KBP50_04435	COG1506	peptidase
KBP50_04440	COG0563	adenylate kinase activity
KBP50_04450	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
KBP50_04455	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KBP50_04460	COG3162	membrane
KBP50_04465	COG3279	Response regulator of the LytR AlgR family
KBP50_04470	COG3275	phosphorelay sensor kinase activity
KBP50_04475	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KBP50_04485	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
KBP50_04515	COG0567	Dehydrogenase, E1 component
KBP50_04520	COG0508	dehydrogenase complex catalyzes the overall conversion of
KBP50_04525	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
KBP50_04530	COG0534	Mate efflux family protein
KBP50_04535	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
KBP50_04540	COG1033	growth of symbiont in host cell
KBP50_04540	COG2409	Drug exporters of the RND superfamily
KBP50_04545	COG1846	Transcriptional regulator
KBP50_04565	COG1132	(ABC) transporter
KBP50_04570	COG1132	(ABC) transporter
KBP50_04575	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KBP50_04580	COG1191	sigma factor activity
KBP50_04600	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KBP50_04605	COG1028	Short-chain dehydrogenase reductase Sdr
KBP50_04615	COG0024	Methionine aminopeptidase
KBP50_04620	COG1757	Na H antiporter
KBP50_04625	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
KBP50_04635	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
KBP50_04645	COG2270	Major facilitator Superfamily
KBP50_04655	COG0114	fumarate hydratase activity
KBP50_04665	COG3842	ATPase activity
KBP50_04670	COG2508	Transcriptional regulator
KBP50_04675	COG3679	Belongs to the UPF0342 family
KBP50_04680	COG1024	Enoyl-CoA hydratase
KBP50_04705	COG0641	radical SAM
KBP50_04715	COG3328	transposase activity
KBP50_04740	COG4152	abc transporter atp-binding protein
KBP50_04745	COG1668	transmembrane transport
KBP50_04750	COG0420	3'-5' exonuclease activity
KBP50_04755	COG4717	serine-type aminopeptidase activity
KBP50_04760	COG1510	regulation of RNA biosynthetic process
KBP50_04765	COG3481	metal-dependent phosphohydrolase, HD sub domain
KBP50_04775	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
KBP50_04795	COG1510	regulation of RNA biosynthetic process
KBP50_04830	COG0537	adenosine 5'-monophosphoramidase activity
KBP50_04840	COG3069	C4-dicarboxylate transmembrane transporter activity
KBP50_04850	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KBP50_04855	COG1131	(ABC) transporter
KBP50_04860	COG4473	ABC transporter
KBP50_04865	COG1473	amidohydrolase
KBP50_04880	COG2814	Major facilitator Superfamily
KBP50_04890	COG4585	Histidine kinase
KBP50_04895	COG2197	response regulator
KBP50_04900	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
KBP50_04905	COG3118	belongs to the thioredoxin family
KBP50_04905	COG0492	ferredoxin-NADP+ reductase activity
KBP50_04915	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KBP50_04920	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
KBP50_04925	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
KBP50_04930	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
KBP50_04935	COG1164	Oligoendopeptidase f
KBP50_04945	COG0095	Lipoate-protein ligase
KBP50_04950	COG0318	PFAM AMP-dependent synthetase and ligase
KBP50_04965	COG0398	Pfam SNARE associated Golgi protein
KBP50_04975	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
KBP50_04980	COG1074	ATP-dependent DNA helicase activity
KBP50_05015	COG2311	Membrane
KBP50_05020	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
KBP50_05035	COG1307	EDD domain protein, DegV family
KBP50_05040	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KBP50_05070	COG0561	phosphatase activity
KBP50_05075	COG1073	alpha beta
KBP50_05080	COG2151	metal-sulfur cluster biosynthetic enzyme
KBP50_05105	COG1744	ABC transporter substrate-binding protein PnrA-like
KBP50_05110	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KBP50_05115	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
KBP50_05130	COG0180	Tryptophanyl-tRNA synthetase
KBP50_05135	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
KBP50_05140	COG0709	Synthesizes selenophosphate from selenide and ATP
KBP50_05150	COG0456	acetyltransferase
KBP50_05155	COG0004	ammonium transporteR
KBP50_05165	COG1393	Belongs to the ArsC family
KBP50_05170	COG4862	establishment of competence for transformation
KBP50_05175	COG4469	Competence protein
KBP50_05180	COG1164	Oligoendopeptidase f
KBP50_05190	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
KBP50_05195	COG2346	COG2346, Truncated hemoglobins
KBP50_05200	COG4116	CYTH
KBP50_05205	COG2357	RelA SpoT domain protein
KBP50_05210	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
KBP50_05215	COG0564	pseudouridine synthase activity
KBP50_05220	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
KBP50_05225	COG2239	Acts as a magnesium transporter
KBP50_05255	COG2323	membrane
KBP50_05260	COG2153	protein acetylation
KBP50_05265	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
KBP50_05270	COG2382	esterase
KBP50_05275	COG1132	(ABC) transporter
KBP50_05280	COG1132	(ABC) transporter
KBP50_05290	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
KBP50_05300	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
KBP50_05305	COG4565	transcriptional regulatory protein
KBP50_05310	COG3290	protein histidine kinase activity
KBP50_05315	COG0745	RESPONSE REGULATOR receiver
KBP50_05360	COG0745	RESPONSE REGULATOR receiver
KBP50_05360	COG2972	Histidine kinase
KBP50_05365	COG3279	Response regulator of the LytR AlgR family
KBP50_05390	COG0006	proline dipeptidase activity
KBP50_05415	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KBP50_05420	COG3938	Belongs to the proline racemase family
KBP50_05430	COG1757	Na H antiporter
KBP50_05435	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
KBP50_05440	COG1012	belongs to the aldehyde dehydrogenase family
KBP50_05465	COG0826	peptidase U32
KBP50_05480	COG0730	response to heat
KBP50_05485	COG0737	Belongs to the 5'-nucleotidase family
KBP50_05495	COG1757	Na H antiporter
KBP50_05510	COG0733	neurotransmitter:sodium symporter activity
KBP50_05520	COG0739	heme binding
KBP50_05530	COG4470	Protein conserved in bacteria
KBP50_05545	COG2445	Protein of unknown function DUF86
KBP50_05550	COG0647	UMP catabolic process
KBP50_05555	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
KBP50_05560	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
KBP50_05565	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
KBP50_05570	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
KBP50_05575	COG4837	Protein of unknown function (DUF1462)
KBP50_05580	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
KBP50_05585	COG0316	Belongs to the HesB IscA family
KBP50_05590	COG0492	ferredoxin-NADP+ reductase activity
KBP50_05595	COG1252	NADH dehydrogenase
KBP50_05610	COG3584	3D domain protein
KBP50_05615	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
KBP50_05625	COG0813	purine-nucleoside phosphorylase activity
KBP50_05630	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
KBP50_05645	COG2032	superoxide dismutase activity
KBP50_05650	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
KBP50_05660	COG0166	Belongs to the GPI family
KBP50_05665	COG2155	Conserved Protein
KBP50_05670	COG1098	S1 RNA binding domain
KBP50_05680	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
KBP50_05695	COG4412	M6 family metalloprotease domain protein
KBP50_05695	COG1404	Belongs to the peptidase S8 family
KBP50_05700	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
KBP50_05710	COG3191	aminopeptidase activity
KBP50_05720	COG2050	protein possibly involved in aromatic compounds catabolism
KBP50_05725	COG1575	Belongs to the MenA family. Type 1 subfamily
KBP50_05730	COG1169	isochorismate synthase
KBP50_05735	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
KBP50_05740	COG0596	Alpha beta hydrolase
KBP50_05745	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
KBP50_05750	COG0318	PFAM AMP-dependent synthetase and ligase
KBP50_05755	COG1505	serine-type exopeptidase activity
KBP50_05760	COG1505	serine-type exopeptidase activity
KBP50_05795	COG0494	nUDIX hydrolase
KBP50_05800	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
KBP50_05805	COG1116	anion transmembrane transporter activity
KBP50_05810	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
KBP50_05815	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
KBP50_05820	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
KBP50_05825	COG0367	asparagine synthase
KBP50_05830	COG4990	cell redox homeostasis
KBP50_05835	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
KBP50_05845	COG1012	belongs to the aldehyde dehydrogenase family
KBP50_05845	COG1454	alcohol dehydrogenase
KBP50_05850	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
KBP50_05855	COG0495	leucyl-tRNA aminoacylation
KBP50_05865	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
KBP50_05885	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
KBP50_05895	COG2081	HI0933 family
KBP50_05900	COG2244	polysaccharide biosynthetic process
KBP50_05905	COG1187	pseudouridine synthase activity
KBP50_05910	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
KBP50_05920	COG0510	thiamine kinase activity
KBP50_05930	COG0220	tRNA (guanine-N7-)-methyltransferase activity
KBP50_05935	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KBP50_05945	COG1363	Peptidase, m42
KBP50_05950	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
KBP50_05960	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KBP50_05965	COG4848	Belongs to the UPF0354 family
KBP50_05970	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KBP50_05975	COG1674	ftsk spoiiie
KBP50_05985	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
KBP50_06005	COG1605	Chorismate mutase
KBP50_06005	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
KBP50_06025	COG0123	including yeast histone deacetylase and acetoin utilization protein
KBP50_06030	COG0517	IMP dehydrogenase activity
KBP50_06035	COG0454	-acetyltransferase
KBP50_06040	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KBP50_06075	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
KBP50_06080	COG2199	diguanylate cyclase activity
KBP50_06080	COG2203	Gaf domain
KBP50_06085	COG1956	GAF domain-containing protein
KBP50_06090	COG1309	transcriptional regulator
KBP50_06095	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
KBP50_06100	COG1104	cysteine desulfurase activity
KBP50_06105	COG0301	tRNA thio-modification
KBP50_06115	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
KBP50_06125	COG3874	Sporulation protein YtfJ
KBP50_06130	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
KBP50_06135	COG0827	DNA restriction-modification system
KBP50_06140	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
KBP50_06145	COG0589	response to stress
KBP50_06155	COG0686	Belongs to the AlaDH PNT family
KBP50_06160	COG0006	proline dipeptidase activity
KBP50_06165	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
KBP50_06170	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
KBP50_06180	COG4109	DRTGG domain
KBP50_06190	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
KBP50_06215	COG0587	DNA-directed DNA polymerase activity
KBP50_06220	COG0281	malic enzyme
KBP50_06225	COG1725	Transcriptional regulator
KBP50_06230	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
KBP50_06235	COG0825	malonyl-CoA metabolic process
KBP50_06240	COG0205	6-phosphofructokinase activity
KBP50_06250	COG3030	protein affecting phage T7 exclusion by the F plasmid
KBP50_06255	COG0628	permease
KBP50_06265	COG0372	Belongs to the citrate synthase family
KBP50_06270	COG0538	isocitrate dehydrogenase activity
KBP50_06275	COG0039	L-malate dehydrogenase activity
KBP50_06285	COG0745	RESPONSE REGULATOR receiver
KBP50_06290	COG5002	protein histidine kinase activity
KBP50_06295	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KBP50_06295	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KBP50_06300	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
KBP50_06305	COG0237	dephospho-CoA kinase activity
KBP50_06315	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
KBP50_06320	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
KBP50_06330	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
KBP50_06335	COG3611	Membrane attachment protein
KBP50_06340	COG1484	DNA-dependent DNA replication
KBP50_06355	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
KBP50_06365	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
KBP50_06370	COG0291	Belongs to the bacterial ribosomal protein bL35 family
KBP50_06375	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
KBP50_06385	COG0398	Pfam SNARE associated Golgi protein
KBP50_06395	COG0756	dUTP diphosphatase activity
KBP50_06400	COG1363	Peptidase, m42
KBP50_06405	COG0741	lytic transglycosylase activity
KBP50_06410	COG1131	(ABC) transporter
KBP50_06435	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KBP50_06440	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
KBP50_06445	COG0072	phenylalanine-tRNA ligase activity
KBP50_06445	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KBP50_06450	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
KBP50_06455	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
KBP50_06460	COG1286	toxin biosynthetic process
KBP50_06465	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
KBP50_06465	COG1796	DNA polymerase
KBP50_06470	COG1193	negative regulation of DNA recombination
KBP50_06475	COG3766	membrane
KBP50_06480	COG0318	PFAM AMP-dependent synthetase and ligase
KBP50_06485	COG1309	transcriptional regulator
KBP50_06490	COG1024	Enoyl-CoA hydratase
KBP50_06495	COG2086	electron transfer activity
KBP50_06500	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
KBP50_06505	COG3118	belongs to the thioredoxin family
KBP50_06510	COG0322	excinuclease ABC activity
KBP50_06515	COG1719	4-vinyl reductase, 4VR
KBP50_06520	COG2009	succinate dehydrogenase
KBP50_06525	COG1053	succinate dehydrogenase
KBP50_06530	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
KBP50_06535	COG0824	Thioesterase
KBP50_06540	COG2197	response regulator
KBP50_06580	COG0551	DNA topoisomerase type I activity
KBP50_06580	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
KBP50_06690	COG1404	Belongs to the peptidase S8 family
KBP50_06755	COG1484	DNA-dependent DNA replication
KBP50_06760	COG2390	Transcriptional regulator
KBP50_06760	COG4584	PFAM Integrase catalytic
KBP50_06780	COG1131	(ABC) transporter
KBP50_06805	COG2085	NADP oxidoreductase coenzyme F420-dependent
KBP50_06820	COG1733	regulation of RNA biosynthetic process
KBP50_06845	COG1725	Transcriptional regulator
KBP50_06865	COG2211	Major facilitator Superfamily
KBP50_06880	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KBP50_06885	COG2226	methyltransferase
KBP50_06900	COG1525	nuclease
KBP50_06910	COG2223	nitrite transmembrane transporter activity
KBP50_06915	COG1846	Transcriptional regulator
KBP50_06920	COG1664	Polymer-forming cytoskeletal
KBP50_06930	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
KBP50_06940	COG1763	Mo-molybdopterin cofactor biosynthetic process
KBP50_06945	COG0314	molybdopterin synthase activity
KBP50_06950	COG0783	Belongs to the Dps family
KBP50_06965	COG1846	Transcriptional regulator
KBP50_06970	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
KBP50_06975	COG5401	PFAM Sporulation and spore germination
KBP50_06980	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
KBP50_06985	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
KBP50_06990	COG0622	Phosphoesterase
KBP50_06995	COG5298	Protein conserved in bacteria
KBP50_07035	COG0840	transmembrane signaling receptor activity
KBP50_07040	COG0154	amidase activity
KBP50_07055	COG0431	NADPH-dependent FMN reductase
KBP50_07055	COG1053	succinate dehydrogenase
KBP50_07055	COG3976	FMN-binding domain protein
KBP50_07060	COG0431	NADPH-dependent FMN reductase
KBP50_07060	COG1053	succinate dehydrogenase
KBP50_07060	COG3976	FMN-binding domain protein
KBP50_07075	COG0544	peptidyl-prolyl cis-trans isomerase activity
KBP50_07080	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
KBP50_07090	COG0218	Necessary for normal cell division and for the maintenance of normal septation
KBP50_07100	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
KBP50_07105	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
KBP50_07110	COG0181	hydroxymethylbilane synthase activity
KBP50_07120	COG0113	porphobilinogen synthase activity
KBP50_07125	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
KBP50_07135	COG1388	LysM domain
KBP50_07135	COG1388	LysM domain
KBP50_07150	COG0525	valine-tRNA ligase activity
KBP50_07160	COG4067	protein conserved in archaea
KBP50_07160	COG0189	ligase activity
KBP50_07165	COG0285	dihydrofolate synthase activity
KBP50_07175	COG2003	Belongs to the UPF0758 family
KBP50_07185	COG1077	Cell shape determining protein MreB Mrl
KBP50_07200	COG0850	regulation of cytokinetic process
KBP50_07205	COG2894	cell division
KBP50_07215	COG1994	Peptidase M50
KBP50_07220	COG0261	This protein binds to 23S rRNA in the presence of protein L20
KBP50_07225	COG2868	ribosomal protein
KBP50_07230	COG0211	Belongs to the bacterial ribosomal protein bL27 family
KBP50_07240	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
KBP50_07245	COG0077	Prephenate dehydratase
KBP50_07255	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
KBP50_07265	COG0217	transcriptional regulatory protein
KBP50_07270	COG0632	four-way junction helicase activity
KBP50_07275	COG2255	four-way junction helicase activity
KBP50_07285	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
KBP50_07290	COG0343	queuine tRNA-ribosyltransferase activity
KBP50_07295	COG1862	Preprotein translocase
KBP50_07310	COG2244	polysaccharide biosynthetic process
KBP50_07320	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
KBP50_07320	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
KBP50_07330	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
KBP50_07330	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
KBP50_07335	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
KBP50_07340	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
KBP50_07345	COG1490	D-aminoacyl-tRNA deacylase activity
KBP50_07360	COG0124	histidyl-tRNA synthetase
KBP50_07365	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
KBP50_07380	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
KBP50_07385	COG1959	2 iron, 2 sulfur cluster binding
KBP50_07390	COG1104	cysteine desulfurase activity
KBP50_07395	COG0482	sulfurtransferase activity
KBP50_07405	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
KBP50_07415	COG0628	permease
KBP50_07420	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
KBP50_07425	COG4472	Bacterial protein of unknown function (DUF965)
KBP50_07430	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
KBP50_07435	COG3906	Belongs to the UPF0473 family
KBP50_07440	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
KBP50_07445	COG4122	O-methyltransferase activity
KBP50_07450	COG0572	uridine kinase
KBP50_07455	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
KBP50_07465	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
KBP50_07485	COG5632	N-Acetylmuramoyl-L-alanine amidase
KBP50_07520	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
KBP50_07525	COG1263	PTS System
KBP50_07525	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KBP50_07535	COG1320	monovalent cation:proton antiporter activity
KBP50_07540	COG2212	antiporter activity
KBP50_07545	COG1863	multisubunit Na H antiporter MnhE subunit
KBP50_07550	COG0651	ATP synthesis coupled electron transport
KBP50_07555	COG1006	Multisubunit Na H antiporter MnhC subunit
KBP50_07560	COG2111	Na H antiporter
KBP50_07560	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
KBP50_07570	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
KBP50_07575	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
KBP50_07580	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
KBP50_07585	COG1534	Rna-binding protein
KBP50_07590	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
KBP50_07595	COG1713	HD superfamily hydrolase involved in NAD metabolism
KBP50_07600	COG0799	negative regulation of ribosome biogenesis
KBP50_07605	COG2226	methyltransferase
KBP50_07615	COG2131	deaminase
KBP50_07620	COG2333	competence protein COMEC
KBP50_07620	COG0658	competence protein
KBP50_07630	COG1466	dna polymerase III delta subunit
KBP50_07635	COG0268	Binds directly to 16S ribosomal RNA
KBP50_07640	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
KBP50_07645	COG0860	N-Acetylmuramoyl-L-alanine amidase
KBP50_07655	COG0481	GTPase activity
KBP50_07660	COG0635	Involved in the biosynthesis of porphyrin-containing compound
KBP50_07665	COG1420	regulation of RNA biosynthetic process
KBP50_07670	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
KBP50_07675	COG0443	Heat shock 70 kDa protein
KBP50_07680	COG0484	heat shock protein binding
KBP50_07685	COG2264	protein methyltransferase activity
KBP50_07690	COG1385	rRNA (uridine-N3-)-methyltransferase activity
KBP50_07695	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
KBP50_07700	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
KBP50_07705	COG0828	Belongs to the bacterial ribosomal protein bS21 family
KBP50_07710	COG1610	YqeY-like protein
KBP50_07715	COG1030	water channel activity
KBP50_07720	COG4864	UPF0365 protein
KBP50_07740	COG1702	phosphate starvation-inducible protein PhoH
KBP50_07745	COG1480	7TM receptor with intracellular HD hydrolase
KBP50_07750	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
KBP50_07755	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
KBP50_07760	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
KBP50_07770	COG1381	Involved in DNA repair and RecF pathway recombination
KBP50_07775	COG0752	glycyl-tRNA synthetase alpha subunit
KBP50_07780	COG0751	glycine-tRNA ligase activity
KBP50_07785	COG0517	IMP dehydrogenase activity
KBP50_07790	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
KBP50_07795	COG0358	DNA primase activity
KBP50_07800	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
KBP50_07815	COG2384	SAM-dependent methyltransferase
KBP50_07820	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
KBP50_07825	COG0513	Belongs to the DEAD box helicase family
KBP50_07850	COG1030	water channel activity
KBP50_07855	COG0704	Plays a role in the regulation of phosphate uptake
KBP50_07895	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
KBP50_07900	COG0477	Major facilitator Superfamily
KBP50_07905	COG0768	penicillin binding
KBP50_07910	COG0704	Plays a role in the regulation of phosphate uptake
KBP50_07925	COG0267	Belongs to the bacterial ribosomal protein bL33 family
KBP50_07930	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
KBP50_07940	COG0457	Tetratricopeptide repeat
KBP50_07940	COG0705	Rhomboid family
KBP50_07950	COG0697	spore germination
KBP50_07960	COG1940	carbohydrate kinase activity
KBP50_07965	COG1368	sulfuric ester hydrolase activity
KBP50_07975	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KBP50_08015	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
KBP50_08030	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
KBP50_08035	COG0404	The glycine cleavage system catalyzes the degradation of glycine
KBP50_08040	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
KBP50_08045	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
KBP50_08050	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
KBP50_08055	COG1321	iron dependent repressor
KBP50_08060	COG1752	Esterase of the alpha-beta hydrolase superfamily
KBP50_08075	COG0006	proline dipeptidase activity
KBP50_08080	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
KBP50_08125	COG0511	ligase activity, forming carbon-carbon bonds
KBP50_08130	COG0439	Biotin carboxylase
KBP50_08135	COG1302	Protein conserved in bacteria
KBP50_08140	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
KBP50_08145	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
KBP50_08150	COG1570	exodeoxyribonuclease VII activity
KBP50_08155	COG1722	exodeoxyribonuclease VII activity
KBP50_08160	COG0142	geranyltranstransferase activity
KBP50_08170	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
KBP50_08175	COG1438	arginine binding
KBP50_08180	COG0497	DNA recombination
KBP50_08185	COG0750	zinc metalloprotease
KBP50_08190	COG0745	RESPONSE REGULATOR receiver
KBP50_08195	COG0527	aspartate kinase activity
KBP50_08205	COG3829	transcription factor binding
KBP50_08205	COG3290	protein histidine kinase activity
KBP50_08210	COG0280	phosphate acetyltransferase
KBP50_08220	COG3426	butyrate kinase activity
KBP50_08225	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KBP50_08230	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
KBP50_08235	COG0022	dehydrogenase e1 component
KBP50_08240	COG0508	dehydrogenase complex catalyzes the overall conversion of
KBP50_08250	COG4129	membrane
KBP50_08260	COG0346	lactoylglutathione lyase activity
KBP50_08265	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
KBP50_08270	COG2195	Cleaves the N-terminal amino acid of tripeptides
KBP50_08275	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
KBP50_08285	COG1012	belongs to the aldehyde dehydrogenase family
KBP50_08290	COG1234	tRNA 3'-trailer cleavage
KBP50_08295	COG0584	glycerophosphoryl diester phosphodiesterase
KBP50_08300	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KBP50_08305	COG0300	oxidoreductase activity
KBP50_08315	COG0667	Aldo Keto reductase
KBP50_08325	COG1379	DNA repair
KBP50_08330	COG1300	Membrane
KBP50_08335	COG0735	belongs to the Fur family
KBP50_08345	COG4974	Belongs to the 'phage' integrase family
KBP50_08350	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
KBP50_08365	COG1686	Belongs to the peptidase S11 family
KBP50_08375	COG2172	sigma factor antagonist activity
KBP50_08395	COG0697	spore germination
KBP50_08405	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
KBP50_08425	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
KBP50_08430	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
KBP50_08435	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
KBP50_08440	COG1686	Belongs to the peptidase S11 family
KBP50_08445	COG2715	membrane protein required for spore maturation
KBP50_08450	COG0700	Nucleoside recognition
KBP50_08455	COG1187	pseudouridine synthase activity
KBP50_08460	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KBP50_08465	COG1333	cytochrome c biogenesis protein
KBP50_08470	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
KBP50_08475	COG0745	RESPONSE REGULATOR receiver
KBP50_08480	COG5002	protein histidine kinase activity
KBP50_08505	COG0514	ATP-dependent DNA helicase (RecQ)
KBP50_08520	COG4862	establishment of competence for transformation
KBP50_08525	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
KBP50_08530	COG0492	ferredoxin-NADP+ reductase activity
KBP50_08540	COG2339	peptidase activity
KBP50_08545	COG3773	Cell wall hydrolase
KBP50_08545	COG3409	Peptidoglycan-binding domain 1 protein
KBP50_08550	COG2959	enzyme of heme biosynthesis
KBP50_08560	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
KBP50_08570	COG0539	negative regulation of cytoplasmic translation
KBP50_08585	COG1160	GTP binding
KBP50_08590	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
KBP50_08610	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
KBP50_08615	COG0776	regulation of translation
KBP50_08625	COG0142	geranyltranstransferase activity
KBP50_08630	COG2226	methyltransferase
KBP50_08635	COG0142	geranyltranstransferase activity
KBP50_08640	COG0105	UTP biosynthetic process
KBP50_08645	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
KBP50_08650	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
KBP50_08655	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
KBP50_08660	COG4401	Chorismate mutase type I
KBP50_08665	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
KBP50_08670	COG0287	Prephenate dehydrogenase
KBP50_08675	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
KBP50_08685	COG5582	Belongs to the UPF0302 family
KBP50_08695	COG0723	plastoquinol--plastocyanin reductase activity
KBP50_08700	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
KBP50_08710	COG4347	Protein of unknown function (DUF1405)
KBP50_08720	COG2738	Putative neutral zinc metallopeptidase
KBP50_08725	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KBP50_08730	COG1694	Mazg nucleotide pyrophosphohydrolase
KBP50_08735	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
KBP50_08740	COG1803	Methylglyoxal synthase
KBP50_08745	COG0438	transferase activity, transferring glycosyl groups
KBP50_08750	COG0617	tRNA 3'-terminal CCA addition
KBP50_08755	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
KBP50_08755	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
KBP50_08760	COG1199	ATP-dependent helicase activity
KBP50_08760	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
KBP50_08775	COG0436	Aminotransferase
KBP50_08780	COG0017	Asparaginyl-tRNA synthetase
KBP50_08785	COG3935	DnaD domain protein
KBP50_08790	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
KBP50_08795	COG4499	WXG100 protein secretion system (Wss), protein YukC
KBP50_08795	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KBP50_08800	COG3331	DNA recombination
KBP50_08825	COG3599	regulation of cell shape
KBP50_08835	COG0116	Belongs to the methyltransferase superfamily
KBP50_08840	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
KBP50_08845	COG3424	synthase
KBP50_08850	COG1755	Isoprenylcysteine carboxyl methyltransferase
KBP50_08855	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
KBP50_08860	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
KBP50_08870	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
KBP50_08875	COG0659	secondary active sulfate transmembrane transporter activity
KBP50_08890	COG1418	mRNA catabolic process
KBP50_08900	COG0791	NLP P60 protein
KBP50_08900	COG1388	LysM domain
KBP50_08905	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
KBP50_08910	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
KBP50_08920	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
KBP50_08925	COG0805	protein transport
KBP50_08930	COG4479	Belongs to the UPF0346 family
KBP50_08935	COG1309	transcriptional regulator
KBP50_08950	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KBP50_08950	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KBP50_08990	COG1254	Belongs to the acylphosphatase family
KBP50_08995	COG0723	plastoquinol--plastocyanin reductase activity
KBP50_08995	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KBP50_09030	COG0789	Transcriptional regulator
KBP50_09040	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KBP50_09070	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
KBP50_09080	COG0390	transport system, permease component
KBP50_09085	COG1126	abc transporter atp-binding protein
KBP50_09090	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KBP50_09095	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
KBP50_09100	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
KBP50_09105	COG1024	Enoyl-CoA hydratase
KBP50_09110	COG0511	ligase activity, forming carbon-carbon bonds
KBP50_09115	COG0439	Biotin carboxylase
KBP50_09120	COG0318	PFAM AMP-dependent synthetase and ligase
KBP50_09125	COG1960	acyl-CoA dehydrogenase activity
KBP50_09135	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
KBP50_09140	COG0187	DNA topoisomerase II activity
KBP50_09145	COG1832	CoA-binding protein
KBP50_09160	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
KBP50_09165	COG1469	GTP cyclohydrolase I activity
KBP50_09170	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
KBP50_09185	COG0824	Thioesterase
KBP50_09200	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KBP50_09205	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
KBP50_09210	COG4191	Histidine kinase
KBP50_09225	COG4846	Membrane protein involved in cytochrome C biogenesis
KBP50_09230	COG2201	protein-glutamate methylesterase activity
KBP50_09235	COG2111	Na H antiporter
KBP50_09240	COG0785	Cytochrome C biogenesis protein
KBP50_09245	COG3763	UPF0154 protein
KBP50_09260	COG4224	UPF0291 protein
KBP50_09265	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
KBP50_09270	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
KBP50_09275	COG3546	catalase activity
KBP50_09280	COG3546	catalase activity
KBP50_09305	COG3152	Membrane
KBP50_09315	COG0174	glutamine synthetase
KBP50_09320	COG0789	Transcriptional regulator
KBP50_09345	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
KBP50_09350	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
KBP50_09355	COG0464	growth
KBP50_09360	COG1923	regulation of RNA biosynthetic process
KBP50_09365	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
KBP50_09370	COG0783	Belongs to the Dps family
KBP50_09375	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
KBP50_09380	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
KBP50_09390	COG4550	Control of competence regulator ComK, YlbF/YmcA
KBP50_09395	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
KBP50_09400	COG2359	stage V sporulation protein S
KBP50_09405	COG1692	metallophosphoesterase
KBP50_09410	COG1418	mRNA catabolic process
KBP50_09420	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
KBP50_09425	COG1546	Belongs to the CinA family
KBP50_09425	COG1058	Belongs to the CinA family
KBP50_09430	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
KBP50_09435	COG1426	Protein conserved in bacteria
KBP50_09450	COG0300	oxidoreductase activity
KBP50_09455	COG0612	Peptidase, M16
KBP50_09460	COG0612	Peptidase, M16
KBP50_09465	COG1079	Belongs to the binding-protein-dependent transport system permease family
KBP50_09470	COG4603	Belongs to the binding-protein-dependent transport system permease family
KBP50_09475	COG3845	ABC transporter
KBP50_09480	COG1744	ABC transporter substrate-binding protein PnrA-like
KBP50_09485	COG2188	Transcriptional regulator
KBP50_09490	COG1674	ftsk spoiiie
KBP50_09500	COG0740	serine-type endopeptidase activity
KBP50_09505	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
KBP50_09510	COG0527	aspartate kinase activity
KBP50_09515	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
KBP50_09520	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
KBP50_09525	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
KBP50_09530	COG1873	PFAM PRC-barrel domain
KBP50_09535	COG0612	Peptidase, M16
KBP50_09540	COG0726	polysaccharide deacetylase
KBP50_09545	COG1185	polyribonucleotide nucleotidyltransferase activity
KBP50_09550	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
KBP50_09555	COG0196	riboflavin kinase activity
KBP50_09560	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
KBP50_09565	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
KBP50_09570	COG1550	Protein conserved in bacteria
KBP50_09575	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
KBP50_09585	COG2740	Nucleic-acid-binding protein implicated in transcription termination
KBP50_09590	COG0195	Participates in both transcription termination and antitermination
KBP50_09595	COG0779	Required for maturation of 30S ribosomal subunits
KBP50_09600	COG2176	DNA-directed DNA polymerase activity
KBP50_09605	COG0750	zinc metalloprotease
KBP50_09610	COG4589	Belongs to the CDS family
KBP50_09615	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
KBP50_09620	COG0233	cytoplasmic translational termination
KBP50_09625	COG0528	UMP kinase activity
KBP50_09630	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
KBP50_09635	COG0052	Belongs to the universal ribosomal protein uS2 family
KBP50_09655	COG1191	sigma factor activity
KBP50_09660	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
KBP50_09665	COG1776	CheC inhibitor of MCP methylation
KBP50_09670	COG0835	chemotaxis
KBP50_09675	COG2198	Histidine kinase
KBP50_09675	COG0643	Histidine kinase
KBP50_09680	COG2201	protein-glutamate methylesterase activity
KBP50_09685	COG0455	bacterial-type flagellum organization
KBP50_09690	COG1419	protein localization to endoplasmic reticulum
KBP50_09695	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
KBP50_09700	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
KBP50_09705	COG1684	flagellar biosynthetic protein fliR
KBP50_09710	COG1987	bacterial-type flagellum assembly
KBP50_09715	COG1338	Plays a role in the flagellum-specific transport system
KBP50_09720	COG3190	flagellar
KBP50_09725	COG2201	protein-glutamate methylesterase activity
KBP50_09730	COG1776	CheC inhibitor of MCP methylation
KBP50_09730	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
KBP50_09735	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
KBP50_09740	COG1580	Controls the rotational direction of flagella during chemotaxis
KBP50_09745	COG1582	Flagellar protein (FlbD)
KBP50_09750	COG4786	Flagellar basal body rod
KBP50_09755	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
KBP50_09760	COG3144	bacterial-type flagellum assembly
KBP50_09775	COG1157	protein secretion by the type III secretion system
KBP50_09785	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
KBP50_09790	COG1766	The M ring may be actively involved in energy transduction
KBP50_09795	COG1677	Flagellar hook-basal body complex protein FliE
KBP50_09800	COG1558	bacterial-type flagellum-dependent cell motility
KBP50_09805	COG1815	bacterial-type flagellum-dependent cell motility
KBP50_09810	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
KBP50_09815	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
KBP50_09820	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
KBP50_09825	COG4974	Belongs to the 'phage' integrase family
KBP50_09835	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
KBP50_09840	COG0758	DNA mediated transformation
KBP50_09845	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
KBP50_09850	COG0045	succinate-CoA ligase (ADP-forming) activity
KBP50_09855	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
KBP50_09865	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
KBP50_09870	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
KBP50_09880	COG0335	large ribosomal subunit rRNA binding
KBP50_09885	COG0336	Belongs to the RNA methyltransferase TrmD family
KBP50_09890	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
KBP50_09900	COG1837	Belongs to the UPF0109 family
KBP50_09905	COG0228	four-way junction DNA binding
KBP50_09910	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
KBP50_09915	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
KBP50_09920	COG0552	protein localization to endoplasmic reticulum
KBP50_09925	COG1196	nuclear chromosome segregation
KBP50_09930	COG4840	Belongs to the UPF0435 family
KBP50_09935	COG0571	ribonuclease III activity
KBP50_09940	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KBP50_09945	COG1028	Short-chain dehydrogenase reductase Sdr
KBP50_09950	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
KBP50_09955	COG0416	fatty acid biosynthetic process
KBP50_09960	COG1349	DNA-binding transcription factor activity
KBP50_09965	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
KBP50_09970	COG1760	l-serine dehydratase
KBP50_09975	COG1760	l-serine dehydratase
KBP50_09985	COG1461	Dihydroxyacetone kinase
KBP50_09990	COG1302	Protein conserved in bacteria
KBP50_09995	COG0227	Belongs to the bacterial ribosomal protein bL28 family
KBP50_10005	COG1564	THIamine pyrophosphokinase
KBP50_10010	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
KBP50_10015	COG1162	GTPase activity
KBP50_10020	COG0515	serine threonine protein kinase
KBP50_10020	COG2815	serine threonine protein kinase
KBP50_10025	COG0631	protein serine/threonine phosphatase activity
KBP50_10030	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
KBP50_10030	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
KBP50_10035	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
KBP50_10040	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
KBP50_10045	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
KBP50_10050	COG1758	RNA polymerase activity
KBP50_10055	COG0194	GDP metabolic process
KBP50_10060	COG2052	Domain of unknown function (DUF370)
KBP50_10065	COG1561	YicC-like family, N-terminal region
KBP50_10070	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
KBP50_10080	COG1764	response to oxidative stress
KBP50_10085	COG0583	DNA-binding transcription factor activity
KBP50_10090	COG2226	methyltransferase
KBP50_10095	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
KBP50_10100	COG0284	orotidine-5'-phosphate decarboxylase activity
KBP50_10105	COG0167	dihydroorotate dehydrogenase activity
KBP50_10110	COG0543	2 iron, 2 sulfur cluster binding
KBP50_10120	COG0505	Belongs to the CarA family
KBP50_10125	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
KBP50_10130	COG0540	Belongs to the ATCase OTCase family
KBP50_10135	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
KBP50_10140	COG0564	pseudouridine synthase activity
KBP50_10145	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
KBP50_10150	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
KBP50_10155	COG3599	regulation of cell shape
KBP50_10160	COG2302	S4 RNA-binding domain
KBP50_10165	COG0762	integral membrane protein
KBP50_10170	COG1799	cell septum assembly
KBP50_10175	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
KBP50_10180	COG1496	oxidoreductase activity
KBP50_10185	COG1873	PFAM PRC-barrel domain
KBP50_10190	COG1191	sigma factor activity
KBP50_10195	COG1191	sigma factor activity
KBP50_10205	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
KBP50_10210	COG0849	cell division
KBP50_10215	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
KBP50_10220	COG0772	Belongs to the SEDS family
KBP50_10225	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
KBP50_10230	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
KBP50_10235	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
KBP50_10240	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
KBP50_10245	COG0768	penicillin binding
KBP50_10250	COG0768	penicillin binding
KBP50_10255	COG4839	cell division protein FtsL
KBP50_10260	COG0275	rRNA processing
KBP50_10265	COG2001	Belongs to the MraZ family
KBP50_10270	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
KBP50_10280	COG0454	-acetyltransferase
KBP50_10290	COG0333	Belongs to the bacterial ribosomal protein bL32 family
KBP50_10295	COG1399	metal-binding, possibly nucleic acid-binding protein
KBP50_10300	COG1323	Belongs to the UPF0348 family
KBP50_10305	COG3480	Lon protease (S16) C-terminal proteolytic domain
KBP50_10310	COG3314	Sporulation integral membrane protein YlbJ
KBP50_10315	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
KBP50_10320	COG0742	ribosomal rna small subunit methyltransferase
KBP50_10325	COG4471	UPF0298 protein
KBP50_10330	COG3679	Belongs to the UPF0342 family
KBP50_10345	COG2340	Cysteine-rich secretory protein family
KBP50_10365	COG3336	cytochrome c oxidase
KBP50_10375	COG1845	cytochrome c oxidase, subunit III
KBP50_10385	COG2010	Cytochrome c
KBP50_10385	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
KBP50_10390	COG0109	protoheme IX farnesyltransferase activity
KBP50_10395	COG1612	heme a metabolic process
KBP50_10400	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
KBP50_10405	COG0772	Belongs to the SEDS family
KBP50_10410	COG4838	Belongs to the UPF0358 family
KBP50_10415	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
KBP50_10445	COG0483	inositol monophosphate 1-phosphatase activity
KBP50_10455	COG4493	Belongs to the UPF0637 family
KBP50_10460	COG4476	Belongs to the UPF0223 family
KBP50_10475	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
KBP50_10495	COG0022	dehydrogenase e1 component
KBP50_10510	COG0242	peptide deformylase activity
KBP50_10515	COG0561	phosphatase activity
KBP50_10525	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
KBP50_10530	COG0569	domain protein
KBP50_10535	COG1132	(ABC) transporter
KBP50_10540	COG1132	(ABC) transporter
KBP50_10545	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KBP50_10555	COG1473	amidohydrolase
KBP50_10560	COG2171	N-acyltransferase activity
KBP50_10565	COG0517	IMP dehydrogenase activity
KBP50_10570	COG0640	Transcriptional regulator
KBP50_10580	COG1408	metallophosphoesterase
KBP50_10595	COG2962	Rard protein
KBP50_10605	COG0436	Aminotransferase
KBP50_10635	COG3300	MHYT domain
KBP50_10635	COG5001	Diguanylate cyclase
KBP50_10640	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
KBP50_10650	COG0778	Nitroreductase
KBP50_10675	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KBP50_10690	COG2323	membrane
KBP50_10700	COG0604	alcohol dehydrogenase
KBP50_10705	COG0003	Pfam Anion-transporting ATPase
KBP50_10715	COG1966	Carbon starvation protein
KBP50_10720	COG3069	C4-dicarboxylate transmembrane transporter activity
KBP50_10730	COG2353	YceI-like domain
KBP50_10735	COG2720	vancomycin resistance protein
KBP50_10740	COG1252	NADH dehydrogenase
KBP50_10745	COG0318	PFAM AMP-dependent synthetase and ligase
KBP50_10770	COG2027	D-alanyl-D-alanine carboxypeptidase
KBP50_10775	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
KBP50_10780	COG0667	Aldo Keto reductase
KBP50_10785	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
KBP50_10795	COG0626	cystathionine gamma-synthase activity
KBP50_10800	COG1735	metal-dependent hydrolase with the TIM-barrel fold
KBP50_10820	COG2188	Transcriptional regulator
KBP50_10825	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
KBP50_10830	COG0419	ATPase involved in DNA repair
KBP50_10835	COG0420	3'-5' exonuclease activity
KBP50_10845	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KBP50_10865	COG2226	methyltransferase
KBP50_10870	COG5504	Zn-dependent protease
KBP50_10875	COG2814	Major facilitator Superfamily
KBP50_10880	COG1301	dicarboxylic acid transport
KBP50_10890	COG0446	pyridine nucleotide-disulphide oxidoreductase
KBP50_10900	COG1063	alcohol dehydrogenase
KBP50_11020	COG0584	glycerophosphoryl diester phosphodiesterase
KBP50_11025	COG0584	glycerophosphoryl diester phosphodiesterase
KBP50_11040	COG1175	transmembrane transport
KBP50_11045	COG3842	ATPase activity
KBP50_11050	COG0860	N-Acetylmuramoyl-L-alanine amidase
KBP50_11055	COG1585	Membrane protein implicated in regulation of membrane protease activity
KBP50_11060	COG2268	Band 7 protein
KBP50_11070	COG1349	DNA-binding transcription factor activity
KBP50_11080	COG2391	methyltransferase activity
KBP50_11115	COG1533	DNA photolyase activity
KBP50_11125	COG5564	TIM-barrel signal transduction protein
KBP50_11135	COG5564	TIM-barrel signal transduction protein
KBP50_11145	COG1408	metallophosphoesterase
KBP50_11160	COG2076	Multidrug Resistance protein
KBP50_11180	COG1228	amidohydrolase
KBP50_11205	COG1131	(ABC) transporter
KBP50_11215	COG3425	synthase
KBP50_11220	COG2202	Pas domain
KBP50_11220	COG1366	Belongs to the anti-sigma-factor antagonist family
KBP50_11225	COG2329	Antibiotic biosynthesis monooxygenase
KBP50_11240	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
KBP50_11265	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
KBP50_11275	COG1012	belongs to the aldehyde dehydrogenase family
KBP50_11290	COG0583	DNA-binding transcription factor activity
KBP50_11295	COG0477	Major facilitator Superfamily
KBP50_11300	COG0204	Acyl-transferase
KBP50_11325	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
KBP50_11330	COG0431	NADPH-dependent FMN reductase
KBP50_11340	COG1368	sulfuric ester hydrolase activity
KBP50_11345	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
KBP50_11375	COG1295	ribonuclease BN
KBP50_11385	COG0501	Belongs to the peptidase M48B family
KBP50_11400	COG0745	RESPONSE REGULATOR receiver
KBP50_11435	COG1063	alcohol dehydrogenase
KBP50_11440	COG3227	Zinc metalloprotease (Elastase)
KBP50_11450	COG0508	dehydrogenase complex catalyzes the overall conversion of
KBP50_11455	COG0022	dehydrogenase e1 component
KBP50_11460	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
KBP50_11465	COG3284	Transcriptional regulator
KBP50_11490	COG2076	Multidrug Resistance protein
KBP50_11505	COG0719	Fe-S assembly protein
KBP50_11510	COG0822	iron-sulfur transferase activity
KBP50_11515	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
KBP50_11520	COG0719	Fe-S assembly protein
KBP50_11525	COG0396	ATPase activity
KBP50_11535	COG1464	Belongs to the NlpA lipoprotein family
KBP50_11540	COG2011	ABC-type metal ion transport system permease component
KBP50_11545	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
KBP50_11550	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KBP50_11555	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
KBP50_11560	COG0509	glycine decarboxylation via glycine cleavage system
KBP50_11565	COG1393	Belongs to the ArsC family
KBP50_11570	COG1960	acyl-CoA dehydrogenase activity
KBP50_11575	COG0183	Belongs to the thiolase family
KBP50_11580	COG1024	Enoyl-CoA hydratase
KBP50_11580	COG1250	3-hydroxyacyl-CoA dehydrogenase
KBP50_11585	COG0431	NADPH-dependent FMN reductase
KBP50_11590	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KBP50_11600	COG1121	(ABC) transporter
KBP50_11605	COG1108	ABC-type Mn2 Zn2 transport systems permease components
KBP50_11610	COG0735	belongs to the Fur family
KBP50_11615	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
KBP50_11630	COG2076	Multidrug Resistance protein
KBP50_11635	COG2076	Multidrug Resistance protein
KBP50_11645	COG0791	NLP P60 protein
KBP50_11645	COG3883	PFAM NLP P60 protein
KBP50_11650	COG2224	Isocitrate lyase
KBP50_11655	COG4129	membrane
KBP50_11660	COG2197	response regulator
KBP50_11665	COG4585	Histidine kinase
KBP50_11670	COG4758	membrane
KBP50_11695	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KBP50_11705	COG1272	protein, Hemolysin III
KBP50_11710	COG0517	IMP dehydrogenase activity
KBP50_11730	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
KBP50_11735	COG0557	exoribonuclease II activity
KBP50_11740	COG1647	Serine aminopeptidase, S33
KBP50_11745	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
KBP50_11765	COG0084	hydrolase, TatD family'
KBP50_11770	COG1116	anion transmembrane transporter activity
KBP50_11775	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
KBP50_11785	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
KBP50_11800	COG1484	DNA-dependent DNA replication
KBP50_11805	COG0148	phosphopyruvate hydratase activity
KBP50_11810	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
KBP50_11815	COG0149	triose-phosphate isomerase activity
KBP50_11820	COG0126	phosphoglycerate kinase activity
KBP50_11840	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
KBP50_11845	COG0328	RNA-DNA hybrid ribonuclease activity
KBP50_11850	COG2112	serine threonine protein kinase
KBP50_11855	COG0710	3-dehydroquinate dehydratase activity
KBP50_11860	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
KBP50_11880	COG1984	allophanate hydrolase subunit 2
KBP50_11885	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
KBP50_11890	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
KBP50_11895	COG1914	H( )-stimulated, divalent metal cation uptake system
KBP50_11905	COG0740	serine-type endopeptidase activity
KBP50_11910	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
KBP50_11915	COG1481	regulation of sporulation
KBP50_11920	COG0391	Required for morphogenesis under gluconeogenic growth conditions
KBP50_11925	COG1660	Displays ATPase and GTPase activities
KBP50_11930	COG1051	belongs to the nudix hydrolase family
KBP50_11935	COG0492	ferredoxin-NADP+ reductase activity
KBP50_11940	COG0457	Tetratricopeptide repeat
KBP50_11945	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
KBP50_11950	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
KBP50_11955	COG0110	maltose O-acetyltransferase activity
KBP50_11960	COG0546	phosphoglycolate phosphatase activity
KBP50_11965	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
KBP50_11970	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
KBP50_11975	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
KBP50_11980	COG1950	PFAM Membrane protein of
KBP50_11985	COG1983	PspC domain protein
KBP50_11990	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
KBP50_11995	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
KBP50_12005	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
KBP50_12010	COG0556	nucleotide-excision repair
KBP50_12015	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
KBP50_12020	COG0726	polysaccharide deacetylase
KBP50_12030	COG3409	Peptidoglycan-binding domain 1 protein
KBP50_12030	COG0793	Belongs to the peptidase S41A family
KBP50_12035	COG0739	heme binding
KBP50_12040	COG2177	Part of the ABC transporter FtsEX involved in
KBP50_12045	COG2884	Cell division ATP-binding protein ftsE
KBP50_12070	COG0653	protein targeting
KBP50_12080	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
KBP50_12090	COG1516	flagellar protein fliS
KBP50_12095	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
KBP50_12100	COG1334	flagellar protein FlaG
KBP50_12105	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
KBP50_12110	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
KBP50_12120	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
KBP50_12125	COG1256	bacterial-type flagellum assembly
KBP50_12125	COG4786	Flagellar basal body rod
KBP50_12145	COG1040	competence protein
KBP50_12150	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
KBP50_12160	COG2197	response regulator
KBP50_12170	COG1307	EDD domain protein, DegV family
KBP50_12175	COG2197	response regulator
KBP50_12185	COG1739	Uncharacterized protein family UPF0029
KBP50_12190	COG0363	glucosamine-6-phosphate deaminase activity
KBP50_12195	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
KBP50_12220	COG0681	Belongs to the peptidase S26 family
KBP50_12240	COG1316	TRANSCRIPTIONal
KBP50_12245	COG0768	penicillin binding
KBP50_12255	COG1012	belongs to the aldehyde dehydrogenase family
KBP50_12265	COG0561	phosphatase activity
KBP50_12270	COG2814	Major facilitator Superfamily
KBP50_12275	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
KBP50_12280	COG0471	metal ion transport
KBP50_12285	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
KBP50_12295	COG2814	Major facilitator Superfamily
KBP50_12300	COG2807	transmembrane transport
KBP50_12315	COG1368	sulfuric ester hydrolase activity
KBP50_12320	COG0840	transmembrane signaling receptor activity
KBP50_12325	COG0840	transmembrane signaling receptor activity
KBP50_12330	COG1012	belongs to the aldehyde dehydrogenase family
KBP50_12375	COG0395	ABC-type sugar transport system, permease component
KBP50_12380	COG1175	transmembrane transport
KBP50_12385	COG1653	transport
KBP50_12390	COG1472	Belongs to the glycosyl hydrolase 3 family
KBP50_12400	COG2971	BadF BadG BcrA BcrD
KBP50_12405	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
KBP50_12415	COG1447	Phosphotransferase system cellobiose-specific component IIA
KBP50_12435	COG1486	melibiose metabolic process
KBP50_12440	COG1609	Transcriptional regulator
KBP50_12450	COG3833	ABC-type maltose transport systems, permease component
KBP50_12455	COG1175	transmembrane transport
KBP50_12460	COG2182	Extracellular solute-binding protein
KBP50_12505	COG2391	methyltransferase activity
KBP50_12515	COG0788	formyltetrahydrofolate deformylase activity
KBP50_12525	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
KBP50_12530	COG3639	organic phosphonate transmembrane transporter activity
KBP50_12535	COG3639	organic phosphonate transmembrane transporter activity
KBP50_12570	COG1595	DNA-templated transcription, initiation
KBP50_12595	COG0305	Participates in initiation and elongation during chromosome replication
KBP50_12610	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
KBP50_12630	COG0497	DNA recombination
KBP50_12660	COG3561	AntA/AntB antirepressor
KBP50_12705	COG4824	toxin secretion phage lysis holin
KBP50_12770	COG5492	domain, Protein
KBP50_12780	COG0740	serine-type endopeptidase activity
KBP50_12830	COG1475	DNA binding
KBP50_12870	COG2226	methyltransferase
KBP50_12955	COG1473	amidohydrolase
KBP50_12980	COG1971	Probably functions as a manganese efflux pump
KBP50_12990	COG1028	Short-chain dehydrogenase reductase Sdr
KBP50_12995	COG2996	Protein conserved in bacteria
KBP50_13005	COG0745	RESPONSE REGULATOR receiver
KBP50_13010	COG0561	phosphatase activity
KBP50_13015	COG2059	Chromate
KBP50_13020	COG2059	Chromate
KBP50_13030	COG1522	sequence-specific DNA binding
KBP50_13035	COG3275	phosphorelay sensor kinase activity
KBP50_13040	COG3279	Response regulator of the LytR AlgR family
KBP50_13045	COG1966	Carbon starvation protein
KBP50_13050	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
KBP50_13055	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
KBP50_13060	COG1461	Dihydroxyacetone kinase
KBP50_13065	COG2376	Dihydroxyacetone kinase
KBP50_13070	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
KBP50_13075	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
KBP50_13085	COG0367	asparagine synthase
KBP50_13100	COG0601	transmembrane transport
KBP50_13105	COG4608	Belongs to the ABC transporter superfamily
KBP50_13125	COG0463	Glycosyl transferase, family 2
KBP50_13135	COG2076	Multidrug Resistance protein
KBP50_13140	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
KBP50_13160	COG1476	TRANSCRIPTIONal
KBP50_13170	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
KBP50_13175	COG1940	carbohydrate kinase activity
KBP50_13185	COG5426	von Willebrand factor, type A
KBP50_13190	COG0395	ABC-type sugar transport system, permease component
KBP50_13205	COG2207	Transcriptional regulator
KBP50_13205	COG1917	Cupin 2, conserved barrel domain protein
KBP50_13210	COG0366	Alpha amylase catalytic
KBP50_13215	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
KBP50_13225	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KBP50_13230	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
KBP50_13235	COG0066	3-isopropylmalate dehydratase activity
KBP50_13240	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
KBP50_13245	COG0473	3-isopropylmalate dehydrogenase activity
KBP50_13250	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
KBP50_13255	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
KBP50_13260	COG0440	acetolactate synthase activity
KBP50_13265	COG0028	Belongs to the TPP enzyme family
KBP50_13270	COG0129	dihydroxy-acid dehydratase activity
KBP50_13275	COG0656	L-ascorbic acid biosynthetic process
KBP50_13280	COG3263	regulation of cellular component size
KBP50_13285	COG1482	cell wall glycoprotein biosynthetic process
KBP50_13290	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
KBP50_13290	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KBP50_13290	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KBP50_13295	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
KBP50_13295	COG3711	transcriptional antiterminator
KBP50_13300	COG1012	belongs to the aldehyde dehydrogenase family
KBP50_13305	COG1486	melibiose metabolic process
KBP50_13310	COG1263	PTS System
KBP50_13310	COG2190	(PTS) system
KBP50_13310	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KBP50_13315	COG3711	transcriptional antiterminator
KBP50_13320	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
KBP50_13325	COG0490	domain, Protein
KBP50_13325	COG2985	domain, Protein
KBP50_13330	COG4948	Mandelate Racemase Muconate Lactonizing
KBP50_13335	COG1288	antiporter activity
KBP50_13340	COG1473	amidohydrolase
KBP50_13355	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
KBP50_13360	COG2814	Major facilitator Superfamily
KBP50_13365	COG4608	Belongs to the ABC transporter superfamily
KBP50_13370	COG0444	Belongs to the ABC transporter superfamily
KBP50_13375	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KBP50_13390	COG1234	tRNA 3'-trailer cleavage
KBP50_13395	COG1737	Transcriptional regulator
KBP50_13400	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KBP50_13405	COG4821	SIS domain
KBP50_13415	COG1735	metal-dependent hydrolase with the TIM-barrel fold
KBP50_13435	COG3711	transcriptional antiterminator
KBP50_13440	COG2706	6-phosphogluconolactonase activity
KBP50_13450	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
KBP50_13455	COG1063	alcohol dehydrogenase
KBP50_13480	COG0318	PFAM AMP-dependent synthetase and ligase
KBP50_13485	COG0318	PFAM AMP-dependent synthetase and ligase
KBP50_13490	COG1804	L-carnitine dehydratase bile acid-inducible protein F
KBP50_13495	COG0183	Belongs to the thiolase family
KBP50_13510	COG1309	transcriptional regulator
KBP50_13515	COG0436	Aminotransferase
KBP50_13520	COG3764	Sortase (surface protein transpeptidase)
KBP50_13530	COG5002	protein histidine kinase activity
KBP50_13535	COG0745	RESPONSE REGULATOR receiver
KBP50_13545	COG3223	Belongs to the PsiE family
KBP50_13550	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KBP50_13555	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
KBP50_13555	COG1918	ferrous iron import across plasma membrane
KBP50_13560	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
KBP50_13565	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
KBP50_13570	COG1119	ATPase activity
KBP50_13580	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
KBP50_13585	COG2022	thiamine diphosphate biosynthetic process
KBP50_13595	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KBP50_13600	COG0352	thiamine-phosphate diphosphorylase activity
KBP50_13615	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
KBP50_13620	COG1999	signal sequence binding
KBP50_13625	COG3414	Phosphotransferase system galactitol-specific IIB component
KBP50_13630	COG3775	system Galactitol-specific IIC component
KBP50_13645	COG0402	S-adenosylhomocysteine deaminase activity
KBP50_13650	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
KBP50_13655	COG1523	belongs to the glycosyl hydrolase 13 family
KBP50_13675	COG3142	Participates in the control of copper homeostasis
KBP50_13695	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KBP50_13695	COG1263	PTS System
KBP50_13700	COG1263	PTS System
KBP50_13700	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KBP50_13705	COG1940	carbohydrate kinase activity
KBP50_13710	COG1621	beta-fructofuranosidase activity
KBP50_13720	COG1609	Transcriptional regulator
KBP50_13725	COG1764	response to oxidative stress
KBP50_13730	COG0789	Transcriptional regulator
KBP50_13755	COG4565	transcriptional regulatory protein
KBP50_13760	COG3290	protein histidine kinase activity
KBP50_13775	COG0697	spore germination
KBP50_13780	COG4126	flavin adenine dinucleotide binding
KBP50_13805	COG0815	Transfers the fatty acyl group on membrane lipoproteins
KBP50_13815	COG0145	ligase activity
KBP50_13825	COG2508	Transcriptional regulator
KBP50_13850	COG1028	Short-chain dehydrogenase reductase Sdr
KBP50_13855	COG4708	membrane
KBP50_13860	COG1309	transcriptional regulator
KBP50_13895	COG3279	Response regulator of the LytR AlgR family
KBP50_13900	COG1454	alcohol dehydrogenase
KBP50_13900	COG1012	belongs to the aldehyde dehydrogenase family
KBP50_13905	COG1917	Cupin 2, conserved barrel domain protein
KBP50_13905	COG4977	sequence-specific DNA binding
KBP50_13925	COG3327	negative regulation of DNA-templated transcription, initiation
KBP50_13930	COG1024	Enoyl-CoA hydratase
KBP50_13935	COG0183	Belongs to the thiolase family
KBP50_13940	COG1250	3-hydroxyacyl-CoA dehydrogenase
KBP50_13945	COG1012	belongs to the aldehyde dehydrogenase family
KBP50_13950	COG1024	Enoyl-CoA hydratase
KBP50_13965	COG2151	metal-sulfur cluster biosynthetic enzyme
KBP50_13980	COG3396	Phenylacetate-CoA oxygenase
KBP50_13985	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
KBP50_13995	COG0492	ferredoxin-NADP+ reductase activity
KBP50_14005	COG0235	Class ii aldolase
KBP50_14015	COG3775	system Galactitol-specific IIC component
KBP50_14020	COG3414	Phosphotransferase system galactitol-specific IIB component
KBP50_14035	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KBP50_14050	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
KBP50_14065	COG0583	DNA-binding transcription factor activity
KBP50_14070	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KBP50_14075	COG0006	proline dipeptidase activity
KBP50_14085	COG1215	transferase activity, transferring glycosyl groups
KBP50_14120	COG3876	Protein conserved in bacteria
KBP50_14130	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
KBP50_14140	COG1486	melibiose metabolic process
KBP50_14145	COG3711	transcriptional antiterminator
KBP50_14145	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
KBP50_14165	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
KBP50_14170	COG1063	alcohol dehydrogenase
KBP50_14175	COG3775	system Galactitol-specific IIC component
KBP50_14180	COG3414	Phosphotransferase system galactitol-specific IIB component
KBP50_14190	COG1438	arginine binding
KBP50_14195	COG0549	Belongs to the carbamate kinase family
KBP50_14205	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
KBP50_14215	COG0018	arginyl-trna synthetase
KBP50_14220	COG3835	regulator
KBP50_14225	COG2610	gluconate transmembrane transporter activity
KBP50_14230	COG1929	Belongs to the glycerate kinase type-1 family
KBP50_14250	COG1396	sequence-specific DNA binding
KBP50_14265	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
KBP50_14270	COG3716	PTS system mannose fructose sorbose family IID component
KBP50_14275	COG3715	PTS system
KBP50_14310	COG0702	epimerase
KBP50_14370	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KBP50_14375	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KBP50_14380	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
KBP50_14385	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
KBP50_14390	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
KBP50_14390	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
KBP50_14395	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
KBP50_14395	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
KBP50_14400	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
KBP50_14410	COG1396	sequence-specific DNA binding
KBP50_14420	COG0717	Belongs to the dCTP deaminase family
KBP50_14450	COG3409	Peptidoglycan-binding domain 1 protein
KBP50_14475	COG2337	Toxic component of a toxin-antitoxin (TA) module
KBP50_14505	COG3409	Peptidoglycan-binding domain 1 protein
KBP50_14510	COG3409	Peptidoglycan-binding domain 1 protein
KBP50_14550	COG0745	RESPONSE REGULATOR receiver
KBP50_14555	COG2205	protein histidine kinase activity
KBP50_14560	COG1136	(ABC) transporter
KBP50_14585	COG0523	cobalamin synthesis protein
KBP50_14590	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
KBP50_14645	COG0179	Fumarylacetoacetate (FAA) hydrolase
KBP50_14660	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KBP50_14665	COG1414	Transcriptional regulator
KBP50_14680	COG0824	Thioesterase
KBP50_14685	COG1960	acyl-CoA dehydrogenase activity
KBP50_14690	COG0183	Belongs to the thiolase family
KBP50_14695	COG1024	Enoyl-CoA hydratase
KBP50_14700	COG1250	3-hydroxyacyl-CoA dehydrogenase
KBP50_14710	COG0318	PFAM AMP-dependent synthetase and ligase
KBP50_14730	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
KBP50_14735	COG4485	Bacterial membrane protein, YfhO
KBP50_14745	COG0463	Glycosyl transferase, family 2
KBP50_14780	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
KBP50_14795	COG1757	Na H antiporter
KBP50_14800	COG0840	transmembrane signaling receptor activity
KBP50_14810	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
KBP50_14815	COG0456	acetyltransferase
KBP50_14825	COG1737	Transcriptional regulator
KBP50_14835	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
KBP50_14840	COG3876	Protein conserved in bacteria
KBP50_14855	COG1131	(ABC) transporter
KBP50_14865	COG1595	DNA-templated transcription, initiation
KBP50_14870	COG1263	PTS System
KBP50_14870	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KBP50_14875	COG3394	polysaccharide catabolic process
KBP50_14880	COG1486	melibiose metabolic process
KBP50_14885	COG2188	Transcriptional regulator
KBP50_14890	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
KBP50_14915	COG1396	sequence-specific DNA binding
KBP50_14930	COG2851	Citrate transporter
KBP50_14935	COG4565	transcriptional regulatory protein
KBP50_14940	COG3290	protein histidine kinase activity
KBP50_14950	COG3386	PFAM SMP-30 Gluconolaconase
KBP50_14955	COG1028	Short-chain dehydrogenase reductase Sdr
KBP50_14965	COG2814	Major facilitator Superfamily
KBP50_14970	COG4948	Mandelate Racemase Muconate Lactonizing
KBP50_14980	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KBP50_14985	COG1414	Transcriptional regulator
KBP50_15025	COG3279	Response regulator of the LytR AlgR family
KBP50_15040	COG1316	TRANSCRIPTIONal
KBP50_15055	COG0297	glycogen (starch) synthase activity
KBP50_15065	COG1216	Glycosyl transferase, family 2
KBP50_15090	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
KBP50_15095	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
KBP50_15100	COG1210	Utp--glucose-1-phosphate uridylyltransferase
KBP50_15120	COG4464	protein tyrosine phosphatase activity
KBP50_15125	COG0489	protein tyrosine kinase activity
KBP50_15130	COG3944	biosynthesis protein
KBP50_15135	COG1388	LysM domain
KBP50_15135	COG0791	NLP P60 protein
KBP50_15145	COG0432	Pfam Uncharacterised protein family UPF0047
KBP50_15165	COG2217	Heavy metal translocating P-type atpase
KBP50_15170	COG1937	Protein conserved in bacteria
KBP50_15180	COG1268	BioY protein
KBP50_15200	COG0300	oxidoreductase activity
KBP50_15210	COG0840	transmembrane signaling receptor activity
KBP50_15220	COG1349	DNA-binding transcription factor activity
KBP50_15225	COG0235	Class ii aldolase
KBP50_15230	COG4806	L-rhamnose isomerase
KBP50_15235	COG1070	Carbohydrate kinase
KBP50_15240	COG2814	Major facilitator Superfamily
KBP50_15245	COG3254	rhamnose metabolic process
KBP50_15250	COG1454	alcohol dehydrogenase
KBP50_15255	COG1054	Belongs to the UPF0176 family
KBP50_15270	COG0840	transmembrane signaling receptor activity
KBP50_15275	COG0386	Belongs to the glutathione peroxidase family
KBP50_15280	COG1126	abc transporter atp-binding protein
KBP50_15285	COG0765	amino acid transport
KBP50_15290	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KBP50_15300	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
KBP50_15310	COG1335	isochorismatase
KBP50_15315	COG2839	Protein conserved in bacteria
KBP50_15320	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
KBP50_15325	COG1876	peptidase activity
KBP50_15330	COG0673	inositol 2-dehydrogenase activity
KBP50_15340	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
KBP50_15345	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
KBP50_15360	COG0437	4 iron, 4 sulfur cluster binding
KBP50_15365	COG0243	molybdopterin cofactor binding
KBP50_15370	COG3381	protein complex oligomerization
KBP50_15400	COG2610	gluconate transmembrane transporter activity
KBP50_15415	COG0765	amino acid transport
KBP50_15420	COG0765	amino acid transport
KBP50_15425	COG1126	abc transporter atp-binding protein
KBP50_15435	COG0812	UDP-N-acetylmuramate dehydrogenase activity
KBP50_15450	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
KBP50_15455	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
KBP50_15460	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
KBP50_15465	COG0131	Imidazoleglycerol-phosphate dehydratase
KBP50_15470	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
KBP50_15475	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
KBP50_15480	COG0107	imidazoleglycerol-phosphate synthase activity
KBP50_15485	COG0140	phosphoribosyl-ATP diphosphatase activity
KBP50_15485	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
KBP50_15490	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
KBP50_15495	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
KBP50_15500	COG4607	ABC-type enterochelin transport system periplasmic component
KBP50_15505	COG4604	ABC transporter, ATP-binding protein
KBP50_15510	COG4605	iron ion homeostasis
KBP50_15515	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KBP50_15520	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
KBP50_15525	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KBP50_15530	COG4876	unkown
KBP50_15535	COG1304	FMN binding
KBP50_15540	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
KBP50_15550	COG0656	L-ascorbic acid biosynthetic process
KBP50_15555	COG0488	(ABC) transporter
KBP50_15575	COG1136	(ABC) transporter
KBP50_15595	COG0840	transmembrane signaling receptor activity
KBP50_15600	COG0519	Catalyzes the synthesis of GMP from XMP
KBP50_15630	COG0778	Nitroreductase
KBP50_15635	COG1181	Belongs to the D-alanine--D-alanine ligase family
KBP50_15645	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
KBP50_15650	COG0512	Glutamine amidotransferase of anthranilate synthase
KBP50_15650	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
KBP50_15655	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
KBP50_15660	COG0134	indole-3-glycerol-phosphate synthase activity
KBP50_15665	COG0135	phosphoribosylanthranilate isomerase activity
KBP50_15670	COG0133	tryptophan synthase activity
KBP50_15675	COG0159	tryptophan synthase activity
KBP50_15685	COG0577	efflux transmembrane transporter activity
KBP50_15685	COG1136	(ABC) transporter
KBP50_15695	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KBP50_15710	COG1131	(ABC) transporter
KBP50_15715	COG1725	Transcriptional regulator
KBP50_15720	COG0708	Exodeoxyribonuclease III
KBP50_15730	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
KBP50_15745	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
KBP50_15760	COG1882	Formate acetyltransferase
KBP50_15765	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
KBP50_15775	COG1012	belongs to the aldehyde dehydrogenase family
KBP50_15775	COG1454	alcohol dehydrogenase
KBP50_15785	COG4869	propanediol catabolic process
KBP50_15800	COG2972	Histidine kinase
KBP50_15805	COG2201	protein-glutamate methylesterase activity
KBP50_15810	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KBP50_15850	COG5506	Protein of unknown function (DUF1694)
KBP50_15855	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
KBP50_15895	COG0693	protein deglycase activity
KBP50_15900	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
KBP50_15905	COG4145	pantothenate transmembrane transporter activity
KBP50_15930	COG3104	oligopeptide transport
KBP50_15950	COG1827	regulation of RNA biosynthetic process
KBP50_15955	COG1104	cysteine desulfurase activity
KBP50_15960	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
KBP50_15965	COG0157	Belongs to the NadC ModD family
KBP50_15970	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
KBP50_15975	COG0737	Belongs to the 5'-nucleotidase family
KBP50_15975	COG1525	nuclease
KBP50_15975	COG4085	toxin activity
KBP50_15995	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KBP50_16000	COG0601	transmembrane transport
KBP50_16005	COG0747	negative chemotaxis
KBP50_16010	COG4608	Belongs to the ABC transporter superfamily
KBP50_16015	COG0444	Belongs to the ABC transporter superfamily
KBP50_16030	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
KBP50_16035	COG0352	thiamine-phosphate diphosphorylase activity
KBP50_16040	COG0789	Transcriptional regulator
KBP50_16045	COG0477	Major facilitator Superfamily
KBP50_16065	COG1556	Lactate utilization protein
KBP50_16070	COG1139	Iron-sulfur cluster binding protein
KBP50_16075	COG0247	lactate metabolic process
KBP50_16080	COG2186	Transcriptional regulator
KBP50_16085	COG1620	l-lactate permease
KBP50_16090	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
KBP50_16105	COG0460	homoserine dehydrogenase
KBP50_16110	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
KBP50_16115	COG0083	homoserine kinase activity
KBP50_16120	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
KBP50_16125	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
KBP50_16130	COG0346	lactoylglutathione lyase activity
KBP50_16135	COG5444	nuclease activity
KBP50_16165	COG1131	(ABC) transporter
KBP50_16180	COG0531	amino acid
KBP50_16185	COG3250	beta-galactosidase activity
KBP50_16205	COG1607	acyl-coa hydrolase
KBP50_16210	COG1413	lyase activity
KBP50_16220	COG1263	PTS System
KBP50_16220	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KBP50_16225	COG0366	Alpha amylase catalytic
KBP50_16230	COG2188	Transcriptional regulator
KBP50_16235	COG0488	(ABC) transporter
KBP50_16240	COG1846	Transcriptional regulator
KBP50_16245	COG0400	carboxylic ester hydrolase activity
KBP50_16260	COG0668	transmembrane transport
KBP50_16275	COG0535	radical SAM domain protein
KBP50_16295	COG1802	Transcriptional regulator
KBP50_16300	COG1114	Component of the transport system for branched-chain amino acids
KBP50_16310	COG1132	(ABC) transporter
KBP50_16315	COG3559	Exporter of polyketide antibiotics
KBP50_16320	COG1131	(ABC) transporter
KBP50_16330	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
KBP50_16330	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
KBP50_16335	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
KBP50_16335	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
KBP50_16340	COG2972	Histidine kinase
KBP50_16340	COG0745	RESPONSE REGULATOR receiver
KBP50_16345	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
KBP50_16350	COG4988	ABC transporter
KBP50_16355	COG1294	oxidase, subunit
KBP50_16360	COG1271	oxidase subunit
KBP50_16365	COG1714	RDD family
KBP50_16370	COG0616	signal peptide processing
KBP50_16390	COG3973	AAA domain
KBP50_16405	COG0745	RESPONSE REGULATOR receiver
KBP50_16410	COG5002	protein histidine kinase activity
KBP50_16415	COG1388	LysM domain
KBP50_16430	COG1695	Transcriptional regulator
KBP50_16485	COG0860	N-Acetylmuramoyl-L-alanine amidase
KBP50_16735	COG1484	DNA-dependent DNA replication
KBP50_16825	COG2066	Belongs to the glutaminase family
KBP50_16835	COG2340	Cysteine-rich secretory protein family
KBP50_16840	COG1077	Cell shape determining protein MreB Mrl
KBP50_16845	COG1804	L-carnitine dehydratase bile acid-inducible protein F
KBP50_16850	COG1960	acyl-CoA dehydrogenase activity
KBP50_16855	COG1012	belongs to the aldehyde dehydrogenase family
KBP50_16880	COG1414	Transcriptional regulator
KBP50_16890	COG1012	belongs to the aldehyde dehydrogenase family
KBP50_16895	COG0028	Belongs to the TPP enzyme family
KBP50_16900	COG0436	Aminotransferase
KBP50_16905	COG1757	Na H antiporter
KBP50_16925	COG0733	neurotransmitter:sodium symporter activity
KBP50_16930	COG0446	pyridine nucleotide-disulphide oxidoreductase
KBP50_16955	COG0488	(ABC) transporter
KBP50_16965	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
KBP50_16970	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
KBP50_16970	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
KBP50_16975	COG0307	riboflavin synthase, alpha
KBP50_16985	COG0840	transmembrane signaling receptor activity
KBP50_16990	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KBP50_16990	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
KBP50_16995	COG0730	response to heat
KBP50_17000	COG0425	Belongs to the sulfur carrier protein TusA family
KBP50_17005	COG2210	Belongs to the sulfur carrier protein TusA family
KBP50_17010	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
KBP50_17010	COG0425	Belongs to the sulfur carrier protein TusA family
KBP50_17020	COG2210	Belongs to the sulfur carrier protein TusA family
KBP50_17030	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
KBP50_17035	COG1937	Protein conserved in bacteria
KBP50_17040	COG0247	lactate metabolic process
KBP50_17045	COG0277	FAD linked oxidase domain protein
KBP50_17050	COG3835	regulator
KBP50_17065	COG1012	belongs to the aldehyde dehydrogenase family
KBP50_17070	COG0166	Belongs to the GPI family
KBP50_17075	COG1619	proteins homologs of microcin C7 resistance protein MccF
KBP50_17090	COG1695	Transcriptional regulator
KBP50_17105	COG1447	Phosphotransferase system cellobiose-specific component IIA
KBP50_17110	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
KBP50_17125	COG3933	PFAM sigma-54 factor interaction domain-containing protein
KBP50_17125	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
KBP50_17135	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
KBP50_17140	COG2079	MmgE PrpD family protein
KBP50_17145	COG0372	Belongs to the citrate synthase family
KBP50_17150	COG0583	DNA-binding transcription factor activity
KBP50_17165	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
KBP50_17170	COG2814	Major facilitator Superfamily
KBP50_17185	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
KBP50_17190	COG0583	DNA-binding transcription factor activity
KBP50_17200	COG3546	catalase activity
KBP50_17205	COG0626	cystathionine gamma-synthase activity
KBP50_17215	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
KBP50_17220	COG1694	Mazg nucleotide pyrophosphohydrolase
KBP50_17245	COG1695	Transcriptional regulator
KBP50_17260	COG4496	protein, YerC YecD
KBP50_17265	COG1757	Na H antiporter
KBP50_17270	COG0351	phosphomethylpyrimidine kinase
KBP50_17280	COG0531	amino acid
KBP50_17285	COG0702	epimerase
KBP50_17300	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
KBP50_17320	COG2378	regulation of single-species biofilm formation
KBP50_17325	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
KBP50_17345	COG3711	transcriptional antiterminator
KBP50_17345	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
KBP50_17350	COG2205	protein histidine kinase activity
KBP50_17355	COG0745	RESPONSE REGULATOR receiver
KBP50_17370	COG1131	(ABC) transporter
KBP50_17405	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
KBP50_17415	COG1597	lipid kinase activity
KBP50_17420	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
KBP50_17425	COG0154	amidase activity
KBP50_17430	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
KBP50_17465	COG4851	CamS sex pheromone cAM373 precursor
KBP50_17470	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
KBP50_17475	COG0210	DNA helicase
KBP50_17480	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
KBP50_17485	COG4496	protein, YerC YecD
KBP50_17490	COG1470	cell adhesion involved in biofilm formation
KBP50_17495	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
KBP50_17510	COG0151	Belongs to the GarS family
KBP50_17515	COG0138	bifunctional purine biosynthesis protein purh
KBP50_17520	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
KBP50_17525	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
KBP50_17530	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
KBP50_17535	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
KBP50_17540	COG0047	phosphoribosylformylglycinamidine synthase activity
KBP50_17545	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
KBP50_17550	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
KBP50_17555	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
KBP50_17560	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
KBP50_17565	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
KBP50_17570	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
KBP50_17580	COG2258	MOSC domain
KBP50_17585	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KBP50_17595	COG0840	transmembrane signaling receptor activity
KBP50_17600	COG2252	PERMEase
KBP50_17610	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
KBP50_17615	COG3842	ATPase activity
KBP50_17640	COG2826	transposase and inactivated derivatives, IS30 family
KBP50_17650	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
KBP50_17655	COG0527	aspartate kinase activity
KBP50_17660	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KBP50_17660	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KBP50_17665	COG0662	Cupin 2, conserved barrel domain protein
KBP50_17675	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
KBP50_17685	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
KBP50_17690	COG3486	L-lysine 6-monooxygenase (NADPH) activity
KBP50_17695	COG2207	Transcriptional regulator
KBP50_17715	COG1181	Belongs to the D-alanine--D-alanine ligase family
KBP50_17720	COG2169	Transcriptional regulator
KBP50_17730	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
KBP50_17735	COG2801	Transposase and inactivated derivatives
KBP50_17760	COG3842	ATPase activity
KBP50_17770	COG1595	DNA-templated transcription, initiation
KBP50_17785	COG1131	(ABC) transporter
KBP50_17800	COG1131	(ABC) transporter
KBP50_17810	COG1595	DNA-templated transcription, initiation
KBP50_17815	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
KBP50_17860	COG0561	phosphatase activity
KBP50_17865	COG2723	6-phospho-beta-galactosidase activity
KBP50_17875	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KBP50_17875	COG2190	(PTS) system
KBP50_17875	COG1263	PTS System
KBP50_17880	COG3711	transcriptional antiterminator
KBP50_17885	COG1486	melibiose metabolic process
KBP50_17905	COG0189	ligase activity
KBP50_17915	COG2814	Major facilitator Superfamily
KBP50_17930	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
KBP50_17940	COG0693	protein deglycase activity
KBP50_17945	COG2378	regulation of single-species biofilm formation
KBP50_17975	COG0741	lytic transglycosylase activity
KBP50_17975	COG0791	NLP P60 protein
KBP50_17980	COG5644	endopeptidase inhibitor activity
KBP50_17995	COG0433	COG0433 Predicted ATPase
KBP50_18030	COG2946	Replication initiation factor
KBP50_18035	COG1674	ftsk spoiiie
KBP50_18070	COG1396	sequence-specific DNA binding
KBP50_18075	COG2856	Zn peptidase
KBP50_18125	COG1674	ftsk spoiiie
KBP50_18130	COG2946	Replication initiation factor
KBP50_18160	COG0791	NLP P60 protein
KBP50_18160	COG0741	lytic transglycosylase activity
KBP50_18235	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
KBP50_18240	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
KBP50_18245	COG0640	Transcriptional regulator
KBP50_18275	COG2226	methyltransferase
KBP50_18300	COG0519	Catalyzes the synthesis of GMP from XMP
KBP50_18300	COG0518	GMP synthase (glutamine-hydrolyzing) activity
KBP50_18305	COG1305	Transglutaminase-like
KBP50_18310	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
KBP50_18315	COG0714	Associated with various cellular activities
KBP50_18325	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
KBP50_18330	COG0154	amidase activity
KBP50_18340	COG0531	amino acid
KBP50_18345	COG0697	spore germination
KBP50_18360	COG0444	Belongs to the ABC transporter superfamily
KBP50_18365	COG4608	Belongs to the ABC transporter superfamily
KBP50_18375	COG0601	transmembrane transport
KBP50_18380	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KBP50_18385	COG0840	transmembrane signaling receptor activity
KBP50_18400	COG2200	EAL domain
KBP50_18415	COG1510	regulation of RNA biosynthetic process
KBP50_18420	COG1012	belongs to the aldehyde dehydrogenase family
KBP50_18425	COG1454	alcohol dehydrogenase
KBP50_18430	COG2197	response regulator
KBP50_18435	COG0071	Belongs to the small heat shock protein (HSP20) family
KBP50_18440	COG1442	glycosyl transferase family 8
KBP50_18450	COG1263	PTS System
KBP50_18450	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KBP50_18450	COG2190	(PTS) system
KBP50_18455	COG2723	6-phospho-beta-galactosidase activity
KBP50_18470	COG1757	Na H antiporter
KBP50_18475	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
KBP50_18480	COG1473	amidohydrolase
KBP50_18485	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
KBP50_18490	COG1473	amidohydrolase
KBP50_18500	COG1879	ABC-type sugar transport system periplasmic component
KBP50_18505	COG1172	Belongs to the binding-protein-dependent transport system permease family
KBP50_18515	COG1869	D-ribose catabolic process
KBP50_18520	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KBP50_18525	COG1609	Transcriptional regulator
KBP50_18530	COG0747	negative chemotaxis
KBP50_18535	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KBP50_18540	COG0601	transmembrane transport
KBP50_18545	COG0444	Belongs to the ABC transporter superfamily
KBP50_18550	COG4608	Belongs to the ABC transporter superfamily
KBP50_18565	COG1966	Carbon starvation protein
KBP50_18590	COG1115	amino acid carrier protein
KBP50_18605	COG5444	nuclease activity
KBP50_18660	COG0791	NLP P60 protein
KBP50_18660	COG1388	LysM domain
KBP50_18670	COG0459	protein refolding
KBP50_18675	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
KBP50_18680	COG1266	CAAX protease self-immunity
KBP50_18690	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
KBP50_18695	COG0488	(ABC) transporter
KBP50_18700	COG0772	Belongs to the SEDS family
KBP50_18705	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
KBP50_18710	COG0456	acetyltransferase
KBP50_18715	COG1214	PFAM Peptidase M22, glycoprotease
KBP50_18720	COG0802	atpase or kinase
KBP50_18725	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
KBP50_18820	COG3091	SprT-like family
KBP50_18825	COG0753	catalase activity
KBP50_18830	COG2183	response to ionizing radiation
KBP50_18840	COG2208	phosphoserine phosphatase activity
KBP50_18845	COG1191	sigma factor activity
KBP50_18850	COG2172	sigma factor antagonist activity
KBP50_18855	COG1366	Belongs to the anti-sigma-factor antagonist family
KBP50_18860	COG2208	phosphoserine phosphatase activity
KBP50_18865	COG2172	sigma factor antagonist activity
KBP50_18870	COG1366	Belongs to the anti-sigma-factor antagonist family
KBP50_18875	COG1366	Belongs to the anti-sigma-factor antagonist family
KBP50_18880	COG2337	Toxic component of a toxin-antitoxin (TA) module
KBP50_18895	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
KBP50_18900	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
KBP50_18900	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
KBP50_18905	COG0736	holo-[acyl-carrier-protein] synthase activity
KBP50_18910	COG0705	Rhomboid family
KBP50_18915	COG1609	Transcriptional regulator
KBP50_18925	COG0546	phosphoglycolate phosphatase activity
KBP50_18930	COG3428	Bacterial PH domain
KBP50_18935	COG3402	PFAM membrane-flanked domain
KBP50_18940	COG0513	Belongs to the DEAD box helicase family
KBP50_18945	COG0697	spore germination
KBP50_18970	COG1846	Transcriptional regulator
KBP50_18980	COG4152	abc transporter atp-binding protein
KBP50_18985	COG1597	lipid kinase activity
KBP50_18995	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
KBP50_19000	COG3639	organic phosphonate transmembrane transporter activity
KBP50_19005	COG3639	organic phosphonate transmembrane transporter activity
KBP50_19010	COG0737	Belongs to the 5'-nucleotidase family
KBP50_19015	COG3212	peptidase
KBP50_19030	COG5002	protein histidine kinase activity
KBP50_19030	COG3850	Histidine kinase
KBP50_19035	COG0745	RESPONSE REGULATOR receiver
KBP50_19050	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KBP50_19065	COG1695	Transcriptional regulator
KBP50_19085	COG1131	(ABC) transporter
KBP50_19090	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
KBP50_19105	COG1217	gtp-binding protein TYPA
KBP50_19115	COG0471	metal ion transport
KBP50_19120	COG3850	Histidine kinase
KBP50_19120	COG5002	protein histidine kinase activity
KBP50_19125	COG0745	RESPONSE REGULATOR receiver
KBP50_19130	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KBP50_19140	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
KBP50_19145	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
KBP50_19155	COG2084	Dehydrogenase
KBP50_19170	COG2226	methyltransferase
KBP50_19195	COG1263	PTS System
KBP50_19195	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KBP50_19200	COG1486	melibiose metabolic process
KBP50_19205	COG1737	Transcriptional regulator
KBP50_19230	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
KBP50_19235	COG2723	6-phospho-beta-galactosidase activity
KBP50_19240	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
KBP50_19240	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
KBP50_19245	COG1447	Phosphotransferase system cellobiose-specific component IIA
KBP50_19260	COG0363	glucosamine-6-phosphate deaminase activity
KBP50_19290	COG3716	PTS system mannose fructose sorbose family IID component
KBP50_19295	COG3715	PTS system
KBP50_19300	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KBP50_19305	COG2222	sugar isomerase
KBP50_19310	COG2188	Transcriptional regulator
KBP50_19335	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
KBP50_19340	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
KBP50_19345	COG2017	converts alpha-aldose to the beta-anomer
KBP50_19355	COG0494	nUDIX hydrolase
KBP50_19375	COG1316	TRANSCRIPTIONal
KBP50_19380	COG1316	TRANSCRIPTIONal
KBP50_19385	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
KBP50_19390	COG0438	transferase activity, transferring glycosyl groups
KBP50_19400	COG1216	Glycosyl transferase, family 2
KBP50_19415	COG0584	glycerophosphoryl diester phosphodiesterase
KBP50_19425	COG1682	transport, permease protein
KBP50_19440	COG0438	transferase activity, transferring glycosyl groups
KBP50_19445	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
KBP50_19460	COG4193	domain, Protein
KBP50_19465	COG1210	Utp--glucose-1-phosphate uridylyltransferase
KBP50_19470	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
KBP50_19475	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
KBP50_19480	COG3266	domain, Protein
KBP50_19480	COG1361	Conserved repeat domain
KBP50_19480	COG2911	Protein conserved in bacteria
KBP50_19485	COG4193	domain, Protein
KBP50_19490	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
KBP50_19495	COG2244	polysaccharide biosynthetic process
KBP50_19515	COG2076	Multidrug Resistance protein
KBP50_19535	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
KBP50_19560	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
KBP50_19565	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
KBP50_19575	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
KBP50_19580	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
KBP50_19585	COG0095	Lipoate-protein ligase
KBP50_19590	COG1737	Transcriptional regulator
KBP50_19595	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
KBP50_19600	COG2190	(PTS) system
KBP50_19600	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KBP50_19600	COG1263	PTS System
KBP50_19605	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
KBP50_19610	COG1447	Phosphotransferase system cellobiose-specific component IIA
KBP50_19615	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
KBP50_19620	COG1486	melibiose metabolic process
KBP50_19625	COG2188	Transcriptional regulator
KBP50_19630	COG3394	polysaccharide catabolic process
KBP50_19645	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
KBP50_19650	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KBP50_19685	COG4786	Flagellar basal body rod
KBP50_19690	COG4786	Flagellar basal body rod
KBP50_19695	COG1077	Cell shape determining protein MreB Mrl
KBP50_19700	COG1609	Transcriptional regulator
KBP50_19710	COG2385	sporulation resulting in formation of a cellular spore
KBP50_19715	COG4608	Belongs to the ABC transporter superfamily
KBP50_19720	COG0791	NLP P60 protein
KBP50_19725	COG4166	transmembrane transport
KBP50_19730	COG0444	Belongs to the ABC transporter superfamily
KBP50_19735	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KBP50_19740	COG0601	transmembrane transport
KBP50_19745	COG2362	D-Aminopeptidase
KBP50_19750	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
KBP50_19760	COG4836	Membrane
KBP50_19765	COG0355	proton-transporting ATP synthase activity, rotational mechanism
KBP50_19770	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
KBP50_19775	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
KBP50_19780	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
KBP50_19785	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
KBP50_19790	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
KBP50_19795	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
KBP50_19800	COG0356	it plays a direct role in the translocation of protons across the membrane
KBP50_19810	COG1404	Belongs to the peptidase S8 family
KBP50_19815	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
KBP50_19820	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
KBP50_19825	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
KBP50_19830	COG4475	Protein of unknown function (DUF436)
KBP50_19835	COG0698	ribose 5-phosphate isomerase
KBP50_19840	COG0840	transmembrane signaling receptor activity
KBP50_19845	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
KBP50_19850	COG1971	Probably functions as a manganese efflux pump
KBP50_19855	COG0009	L-threonylcarbamoyladenylate synthase
KBP50_19875	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
KBP50_19880	COG1435	thymidine kinase activity
KBP50_19885	COG0254	rRNA binding
KBP50_19890	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
KBP50_19895	COG1494	fructose-1,6-bisphosphatase
KBP50_19900	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
KBP50_19905	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
KBP50_19910	COG0191	fructose-bisphosphate aldolase activity
KBP50_19915	COG0745	RESPONSE REGULATOR receiver
KBP50_19920	COG0504	CTP synthase activity
KBP50_19925	COG3343	RNA polymerase activity
KBP50_19930	COG1309	transcriptional regulator
KBP50_19935	COG1960	acyl-CoA dehydrogenase activity
KBP50_19940	COG1960	acyl-CoA dehydrogenase activity
KBP50_19945	COG1250	3-hydroxyacyl-CoA dehydrogenase
KBP50_19950	COG0183	Belongs to the thiolase family
KBP50_19955	COG2181	nitrate reductase activity
KBP50_19955	COG0247	lactate metabolic process
KBP50_19960	COG1882	Formate acetyltransferase
KBP50_19965	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
KBP50_19970	COG0018	arginyl-trna synthetase
KBP50_19980	COG0039	L-malate dehydrogenase activity
KBP50_19985	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KBP50_19995	COG3465	dGTPase activity
KBP50_20000	COG1078	dGTPase activity
KBP50_20005	COG0095	Lipoate-protein ligase
KBP50_20010	COG0280	phosphate acetyltransferase
KBP50_20015	COG3253	May function as heme-dependent peroxidase
KBP50_20025	COG3773	Cell wall hydrolase
KBP50_20040	COG2363	Small membrane protein
KBP50_20055	COG1845	cytochrome c oxidase, subunit III
KBP50_20060	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
KBP50_20065	COG2010	Cytochrome c
KBP50_20065	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
KBP50_20075	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
KBP50_20080	COG3314	Sporulation integral membrane protein YlbJ
KBP50_20085	COG3594	Acyltransferase
KBP50_20090	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
KBP50_20095	COG3285	dna ligase
KBP50_20095	COG1793	dna ligase
KBP50_20100	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
KBP50_20130	COG0861	Integral membrane protein TerC family
KBP50_20135	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
KBP50_20140	COG0628	permease
KBP50_20160	COG1114	Component of the transport system for branched-chain amino acids
KBP50_20165	COG0514	ATP-dependent DNA helicase (RecQ)
KBP50_20175	COG1733	regulation of RNA biosynthetic process
KBP50_20180	COG1115	amino acid carrier protein
KBP50_20185	COG1607	acyl-coa hydrolase
KBP50_20190	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
KBP50_20195	COG1737	Transcriptional regulator
KBP50_20200	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
KBP50_20205	COG1263	PTS System
KBP50_20205	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KBP50_20210	COG2873	o-acetylhomoserine
KBP50_20225	COG0561	phosphatase activity
KBP50_20230	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
KBP50_20240	COG1447	Phosphotransferase system cellobiose-specific component IIA
KBP50_20245	COG2755	lipolytic protein G-D-S-L family
KBP50_20260	COG0488	(ABC) transporter
KBP50_20265	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KBP50_20270	COG0156	8-amino-7-oxononanoate synthase activity
KBP50_20275	COG1388	LysM domain
KBP50_20275	COG3584	3D domain protein
KBP50_20285	COG2814	Major facilitator Superfamily
KBP50_20290	COG0534	Mate efflux family protein
KBP50_20300	COG0251	oxidation-reduction process
KBP50_20305	COG0741	lytic transglycosylase activity
KBP50_20325	COG2358	TRAP transporter, solute receptor (TAXI family
KBP50_20335	COG2070	2-Nitropropane dioxygenase
KBP50_20345	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
KBP50_20355	COG1136	(ABC) transporter
KBP50_20365	COG2814	Major facilitator Superfamily
KBP50_20380	COG1263	PTS System
KBP50_20380	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KBP50_20390	COG1737	Transcriptional regulator
KBP50_20395	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
KBP50_20400	COG2032	superoxide dismutase activity
KBP50_20435	COG4152	abc transporter atp-binding protein
KBP50_20450	COG0655	NAD(P)H dehydrogenase (quinone) activity
KBP50_20455	COG4991	sh3 domain protein
KBP50_20455	COG3103	Sh3 type 3 domain protein
KBP50_20455	COG0860	N-Acetylmuramoyl-L-alanine amidase
KBP50_20465	COG2226	methyltransferase
KBP50_20470	COG4282	regulation of fungal-type cell wall biogenesis
KBP50_20475	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
KBP50_20485	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
KBP50_20490	COG2323	membrane
KBP50_20495	COG3383	formate dehydrogenase (NAD+) activity
KBP50_20500	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
KBP50_20505	COG0753	catalase activity
KBP50_20510	COG3011	Protein conserved in bacteria
KBP50_20515	COG0820	rRNA (adenine-C2-)-methyltransferase activity
KBP50_20525	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KBP50_20530	COG0655	NAD(P)H dehydrogenase (quinone) activity
KBP50_20535	COG0501	Belongs to the peptidase M48B family
KBP50_20555	COG0427	acetyl-CoA hydrolase
KBP50_20570	COG1252	NADH dehydrogenase
KBP50_20580	COG1346	cytolysis
KBP50_20585	COG1380	Effector of murein hydrolase LrgA
KBP50_20590	COG0137	argininosuccinate synthase activity
KBP50_20615	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
KBP50_20620	COG0573	inorganic phosphate transmembrane transporter activity
KBP50_20625	COG0581	inorganic phosphate transmembrane transporter activity
KBP50_20630	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
KBP50_20660	COG0561	phosphatase activity
KBP50_20670	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KBP50_20670	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KBP50_20670	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
KBP50_20675	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KBP50_20675	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KBP50_20675	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
KBP50_20680	COG1105	Belongs to the carbohydrate kinase PfkB family
KBP50_20690	COG0346	lactoylglutathione lyase activity
KBP50_20695	COG1011	Hydrolase
KBP50_20705	COG0577	efflux transmembrane transporter activity
KBP50_20710	COG1136	(ABC) transporter
KBP50_20715	COG3871	stress protein (general stress protein 26)
KBP50_20735	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
KBP50_20760	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
KBP50_20765	COG1609	Transcriptional regulator
KBP50_20780	COG1131	(ABC) transporter
KBP50_20785	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
KBP50_20790	COG1263	PTS System
KBP50_20790	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KBP50_20790	COG2190	(PTS) system
KBP50_20795	COG3711	transcriptional antiterminator
KBP50_20800	COG1263	PTS System
KBP50_20800	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KBP50_20815	COG4821	SIS domain
KBP50_20820	COG2188	Transcriptional regulator
KBP50_20845	COG1607	acyl-coa hydrolase
KBP50_20850	COG0583	DNA-binding transcription factor activity
KBP50_20865	COG0785	Cytochrome C biogenesis protein
KBP50_20870	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KBP50_20875	COG0745	RESPONSE REGULATOR receiver
KBP50_20880	COG5002	protein histidine kinase activity
KBP50_20885	COG1937	Protein conserved in bacteria
KBP50_20890	COG4536	flavin adenine dinucleotide binding
KBP50_20895	COG3949	Membrane
KBP50_20900	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
KBP50_20910	COG2719	SpoVR family
KBP50_20915	COG0803	Belongs to the bacterial solute-binding protein 9 family
KBP50_20920	COG1121	(ABC) transporter
KBP50_20925	COG1321	iron dependent repressor
KBP50_20925	COG1108	ABC-type Mn2 Zn2 transport systems permease components
KBP50_20930	COG1108	ABC-type Mn2 Zn2 transport systems permease components
KBP50_20940	COG2718	Belongs to the UPF0229 family
KBP50_20945	COG2766	serine protein kinase
KBP50_20950	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KBP50_20955	COG1120	ATPase activity
KBP50_20970	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
KBP50_20980	COG3639	organic phosphonate transmembrane transporter activity
KBP50_20985	COG3639	organic phosphonate transmembrane transporter activity
KBP50_20990	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
KBP50_21000	COG0613	PHP domain protein
KBP50_21005	COG4778	phosphonate C-P lyase system protein PhnL
KBP50_21010	COG3454	Phosphonate metabolism
KBP50_21015	COG4107	phosphonate C-P lyase system protein PhnK
KBP50_21020	COG3627	carbon phosphorus lyase activity
KBP50_21050	COG0395	ABC-type sugar transport system, permease component
KBP50_21060	COG3842	ATPase activity
KBP50_21080	COG0110	maltose O-acetyltransferase activity
KBP50_21090	COG0583	DNA-binding transcription factor activity
KBP50_21115	COG2116	formate transmembrane transporter activity
KBP50_21135	COG1280	lysine exporter protein (LysE YggA)
KBP50_21140	COG3403	YqcI/YcgG family
KBP50_21155	COG5577	PFAM Coat F domain
KBP50_21160	COG2814	Major facilitator Superfamily
KBP50_21170	COG2964	Protein conserved in bacteria
KBP50_21180	COG1760	l-serine dehydratase
KBP50_21185	COG1760	l-serine dehydratase
KBP50_21190	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KBP50_21195	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KBP50_21205	COG1131	(ABC) transporter
KBP50_21210	COG0842	Transport permease protein
KBP50_21215	COG1309	transcriptional regulator
KBP50_21225	COG1447	Phosphotransferase system cellobiose-specific component IIA
KBP50_21230	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
KBP50_21235	COG3711	transcriptional antiterminator
KBP50_21235	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
KBP50_21240	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
KBP50_21245	COG1510	regulation of RNA biosynthetic process
KBP50_21250	COG1125	glycine betaine transport
KBP50_21250	COG0517	IMP dehydrogenase activity
KBP50_21255	COG1174	glycine betaine transport
KBP50_21260	COG1732	Glycine betaine
KBP50_21265	COG1174	glycine betaine transport
KBP50_21275	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KBP50_21275	COG2190	(PTS) system
KBP50_21275	COG1263	PTS System
KBP50_21280	COG1486	melibiose metabolic process
KBP50_21285	COG1737	Transcriptional regulator
KBP50_21295	COG2056	Na+-H+ antiporter family
KBP50_21300	COG0179	Fumarylacetoacetate (FAA) hydrolase
KBP50_21305	COG3588	fructose-bisphosphate aldolase
KBP50_21310	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
KBP50_21310	COG3408	Glycogen debranching enzyme
KBP50_21315	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KBP50_21315	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
KBP50_21315	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KBP50_21335	COG0726	polysaccharide deacetylase
KBP50_21355	COG0803	Belongs to the bacterial solute-binding protein 9 family
KBP50_21360	COG1108	ABC-type Mn2 Zn2 transport systems permease components
KBP50_21365	COG1121	(ABC) transporter
KBP50_21450	COG1131	(ABC) transporter
KBP50_21565	COG3773	Cell wall hydrolase
KBP50_21585	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
KBP50_21620	COG0586	Pfam SNARE associated Golgi protein
KBP50_21625	COG0688	phosphatidylethanolamine metabolic process
KBP50_21630	COG1183	phosphatidylcholine synthase activity
KBP50_21650	COG2027	D-alanyl-D-alanine carboxypeptidase
KBP50_21660	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
KBP50_21660	COG3266	domain, Protein
KBP50_21660	COG4932	domain protein
KBP50_21665	COG1028	Short-chain dehydrogenase reductase Sdr
KBP50_21670	COG0406	alpha-ribazole phosphatase activity
KBP50_21680	COG0529	Catalyzes the synthesis of activated sulfate
KBP50_21685	COG0471	metal ion transport
KBP50_21685	COG3273	potassium ion transport
KBP50_21690	COG2046	Belongs to the sulfate adenylyltransferase family
KBP50_21700	COG1648	precorrin-2 dehydrogenase activity
KBP50_21700	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
KBP50_21715	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
KBP50_21720	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
KBP50_21725	COG0175	sulfate reduction
KBP50_21730	COG2076	Multidrug Resistance protein
KBP50_21735	COG2076	Multidrug Resistance protein
KBP50_21740	COG1309	transcriptional regulator
KBP50_21745	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KBP50_21750	COG0450	alkyl hydroperoxide reductase
KBP50_21755	COG1132	(ABC) transporter
KBP50_21765	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KBP50_21770	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
KBP50_21775	COG4853	Protein conserved in bacteria
KBP50_21780	COG4863	YycH protein
KBP50_21785	COG5002	protein histidine kinase activity
KBP50_21790	COG0745	RESPONSE REGULATOR receiver
KBP50_21795	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
KBP50_21800	COG0305	Participates in initiation and elongation during chromosome replication
KBP50_21805	COG0359	binds to the 23S rRNA
KBP50_21810	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
KBP50_21825	COG0725	ABC transporter, periplasmic molybdate-binding protein
KBP50_21840	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
KBP50_21845	COG0629	single-stranded DNA binding
KBP50_21850	COG0360	Binds together with S18 to 16S ribosomal RNA
KBP50_21855	COG0012	GTP binding
KBP50_21860	COG4481	Protein conserved in bacteria
KBP50_21865	COG0668	transmembrane transport
KBP50_21870	COG3949	Membrane
KBP50_21885	COG1475	DNA binding
KBP50_21890	COG1192	Involved in chromosome partitioning
KBP50_21895	COG1475	DNA binding
KBP50_21900	COG0357	Ribosomal RNA small subunit methyltransferase G
KBP50_21905	COG0445	tRNA wobble uridine modification
KBP50_21910	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
KBP50_21915	COG1847	R3H domain protein
KBP50_21920	COG0706	membrane insertase activity
KBP50_21925	COG0594	ribonuclease P activity
KBP50_21930	COG0230	Belongs to the bacterial ribosomal protein bL34 family