locus-tag class description CFK37_00015 ENOG4107RJ5 oxidoreductase CFK37_00020 ENOG4105CK5 oxidoreductase CFK37_00025 ENOG4105FDP GntR family transcriptional regulator CFK37_00050 ENOG4105CJ1 ABC, transporter CFK37_00060 ENOG4105WH1 Two component transcriptional regulator luxr family CFK37_00095 ENOG4105WYW fructose-bisphosphate aldolase CFK37_00100 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily CFK37_00105 ENOG4105CK7 Sodium proline symporter CFK37_00110 ENOG4105DC7 peptidase M24 CFK37_00140 ENOG4105EN6 Membrane CFK37_00145 ENOG4107S4Y M20 DapE family protein YgeY CFK37_00150 ENOG4105CH6 catalase CFK37_00155 ENOG41061TZ Short-chain dehydrogenase reductase Sdr CFK37_00160 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase CFK37_00170 ENOG41076HS cation diffusion facilitator family transporter CFK37_00195 ENOG4105BZ1 (ABC) transporter CFK37_00200 ENOG4105BZ1 (ABC) transporter CFK37_00210 ENOG4108ZMI UPF0477 protein CFK37_00220 ENOG4105H67 Protein of unknown function (DUF421) CFK37_00225 ENOG4105WG9 Conserved Protein CFK37_00230 ENOG4108IG5 Transcriptional regulator CFK37_00235 ENOG4105EYF MMPL domain protein CFK37_00260 ENOG4108SUT Major Facilitator Superfamily CFK37_00270 ENOG41090MY MarR family Transcriptional regulator CFK37_00280 ENOG410900G Protein of unknown function (DUF421) CFK37_00285 ENOG4108MR7 Arylsulfotransferase CFK37_00290 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) CFK37_00315 ENOG4107PBV potassium channel CFK37_00330 ENOG4105CEY Amp-dependent synthetase and ligase CFK37_00355 ENOG4105C9U ATP-dependent DNA helicase RecQ CFK37_00385 ENOG4105X5K response regulator receiver protein CFK37_00400 ENOG4105E0M Sulfatase CFK37_00405 ENOG4107STF Involved in phosphonate degradation (By similarity) CFK37_00410 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) CFK37_00415 ENOG4108SQ9 flavin reductase domain protein, FMN-binding CFK37_00420 ENOG4108ZHR arsR family transcriptional regulator CFK37_00425 ENOG4108VNY MOSC domain protein CFK37_00450 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) CFK37_00460 ENOG4105E8R UPF0173 metal-dependent hydrolase CFK37_00480 ENOG4105CJW magnesium transporter CFK37_00490 ENOG4107S1Q Phosphatase CFK37_00495 ENOG4105EMS pseudouridine synthase CFK37_00500 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) CFK37_00510 ENOG4105MIX Adenylate cyclase CFK37_00515 ENOG4108Z18 K06886 hemoglobin CFK37_00520 ENOG4105T58 Dithiol-disulfide isomerase CFK37_00525 ENOG4105DPN Oligoendopeptidase f CFK37_00540 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) CFK37_00555 ENOG4105CHU acetyl-coa acetyltransferase CFK37_00565 ENOG41069ER domain protein CFK37_00570 ENOG4105C31 Tryptophanyl-tRNA synthetase CFK37_00575 ENOG4108KU1 UPF0736 protein CFK37_00585 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) CFK37_00590 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) CFK37_00595 ENOG4107RMD Basic membrane lipoprotein CFK37_00615 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) CFK37_00635 ENOG4108ZAF Molybdopterin CFK37_00640 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein CFK37_00645 ENOG4105VG1 fes assembly suf system protein CFK37_00650 ENOG4108MXZ Esterase CFK37_00655 ENOG4108KP7 hydrolase CFK37_00670 ENOG4107AYK membrAne CFK37_00675 ENOG4105EPR degv family CFK37_00680 ENOG4108IUK alpha amylase, catalytic CFK37_00690 ENOG4105EHG Permease protein CFK37_00695 ENOG4105DQ5 transport system permease protein CFK37_00705 ENOG4105YHS UPF0344 protein CFK37_00710 ENOG4105C8Y Acetylornithine aminotransferase CFK37_00720 ENOG4108K88 Membrane CFK37_00725 ENOG4108SUT Major Facilitator Superfamily CFK37_00740 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) CFK37_00745 ENOG4105DNP FAD linked oxidase domain protein CFK37_00750 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation CFK37_00755 ENOG4105C5N The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination CFK37_00780 ENOG4105CEY Amp-dependent synthetase and ligase CFK37_00785 ENOG4105DF9 Lipoate-protein, ligase CFK37_00790 ENOG4108RQ5 Beta-lactamase domain-containing protein CFK37_00795 ENOG4106AXD CFK37_00805 ENOG4105C1Q protoporphyrinogen oxidase CFK37_00810 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) CFK37_00815 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) CFK37_00820 ENOG4105BZ4 penicillin-binding protein CFK37_00825 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation CFK37_00835 ENOG4105KVY Required for disulfide bond formation in some proteins (By similarity) CFK37_00840 ENOG4105WH1 Two component transcriptional regulator luxr family CFK37_00845 ENOG4105ENE Histidine kinase CFK37_00855 ENOG4107Y80 Major Facilitator superfamily CFK37_00865 ENOG4108UQY Iron-storage protein CFK37_00885 ENOG4105K59 histidine triad (HIT) protein CFK37_00890 ENOG4105NBU tryptophan transport protein CFK37_00915 ENOG4108IJ7 Glycine betaine CFK37_00920 ENOG4107HG4 Transcriptional regulator CFK37_00940 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) CFK37_00950 ENOG4105EQI Metal Dependent Phosphohydrolase CFK37_00955 ENOG4105TRT Transcriptional regulator CFK37_00960 ENOG4106D4I domain protein CFK37_00965 ENOG4107VRP DNA repair exonuclease CFK37_00970 ENOG4105RHA ABC transporter, permease CFK37_00975 ENOG4108IUX (ABC) transporter CFK37_01010 ENOG4105CGU Enoyl-CoA hydratase CFK37_01015 ENOG4105WZB UPF0342 protein CFK37_01035 ENOG4105C9Q fumarate hydratase class II CFK37_01045 ENOG4105DEU major facilitator superfamily CFK37_01060 ENOG4105VRR gCN5-related N-acetyltransferase CFK37_01070 ENOG4108UMN azlc family CFK37_01080 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) CFK37_01090 ENOG410904N short-chain dehydrogenase reductase CFK37_01095 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) CFK37_01100 ENOG4105C28 cystathionine CFK37_01115 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) CFK37_01135 ENOG4108WZW RNA polymerase sigma CFK37_01150 ENOG4105BZ1 (ABC) transporter CFK37_01155 ENOG4105BZ1 (ABC) transporter CFK37_01175 ENOG4108B31 Spore germination protein CFK37_01195 ENOG4105EYF MMPL domain protein CFK37_01200 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) CFK37_01205 ENOG4107QMU Mate efflux family protein CFK37_01210 ENOG4105C26 Dehydrogenase CFK37_01225 ENOG4105D9N nucleoside CFK37_01235 ENOG4105C7N Xanthine uracil vitamin C permease CFK37_01240 ENOG4105C7S Dehydrogenase CFK37_01245 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 CFK37_01260 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) CFK37_01265 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) CFK37_01285 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein CFK37_01295 ENOG4106DF1 CFK37_01320 ENOG4105CIS alcohol dehydrogenase CFK37_01335 ENOG4107DZX Small, acid-soluble spore protein P CFK37_01345 ENOG4108QCI YvbH-like oligomerisation region CFK37_01365 ENOG4105CEY Amp-dependent synthetase and ligase CFK37_01370 ENOG4105II7 pyrroline-5-carboxylate reductase CFK37_01375 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) CFK37_01385 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) CFK37_01395 ENOG4105D03 DNA-3-methyladenine glycosylase II CFK37_01420 ENOG41085PJ rdd domain containing protein CFK37_01425 ENOG4105CG6 trap dicarboxylate transporter dctm subunit CFK37_01430 ENOG4105XDZ Tripartite ATP-independent periplasmic transporter CFK37_01435 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit CFK37_01440 ENOG4105CT4 transporter CFK37_01460 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) CFK37_01480 ENOG4105D7K pfkb domain protein CFK37_01485 ENOG4108UHU Aldolase CFK37_01490 ENOG4105DMW Dehydrogenase reductase CFK37_01495 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) CFK37_01500 ENOG4105D2H Uronic isomerase CFK37_01510 ENOG4105C9S Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (By similarity) CFK37_01520 ENOG4107YCY Transcriptional regulator CFK37_01525 ENOG41073TP transcriptional regulator CFK37_01530 ENOG4107SCR N-acetylneuraminate lyase CFK37_01535 ENOG4107RJ1 sodium solute CFK37_01545 ENOG4107STQ Multicopper oxidase CFK37_01550 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein CFK37_01560 ENOG4105EMU Dehydrogenase CFK37_01570 ENOG4106A3M Cytochrome p-450 CFK37_01600 ENOG4105RHY Pfam:UPF0157 CFK37_01605 ENOG4105CK7 Sodium proline symporter CFK37_01640 ENOG4105DY9 regulatoR CFK37_01645 ENOG4108HRK Histidine kinase CFK37_01660 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) CFK37_01670 ENOG41068WN CFK37_01675 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase CFK37_01680 ENOG4105CDH Citrulline--aspartate ligase CFK37_01705 ENOG4105CJ1 ABC, transporter CFK37_01710 ENOG4108UKS UPF0398 protein CFK37_01720 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component CFK37_01730 ENOG4107Z6I Thiamine biosynthesis protein CFK37_01735 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) CFK37_01740 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) CFK37_01775 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase CFK37_01790 ENOG4107VFR oxidoreductase CFK37_01805 ENOG4105E2A Dehydrogenase CFK37_01815 ENOG4105FDR Membrane CFK37_01910 ENOG4105TUA UPF0295 protein CFK37_01915 ENOG4105DDQ anthranilate synthase CFK37_01920 ENOG4105CRQ synthase (Component I) CFK37_01925 ENOG4105G5W regulator Fur family CFK37_01930 ENOG4108WBT adenosyltransferase CFK37_01945 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen CFK37_01975 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase CFK37_01980 ENOG4105BZ1 (ABC) transporter CFK37_01985 ENOG4105EVI UPF0374 protein CFK37_01995 ENOG4105CEN a g-specific adenine glycosylase CFK37_02000 ENOG41067AE Membrane-bound metal-dependent hydrolase CFK37_02015 ENOG410902V Modulates RecA activity (By similarity) CFK37_02020 ENOG4105ECP epimerase CFK37_02040 ENOG4105DVE abc transporter atp-binding protein CFK37_02065 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) CFK37_02080 ENOG4107RIQ Sulfate adenylate transferase CFK37_02090 ENOG4107UCJ Catalyzes the synthesis of activated sulfate (By similarity) CFK37_02095 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase CFK37_02100 ENOG4105C5E polysaccharide biosynthesis protein CFK37_02125 ENOG4105EKQ RNA-directed DNA polymerase CFK37_02140 ENOG4108ISG Major Facilitator CFK37_02145 ENOG4105C59 p-type ATPase CFK37_02150 ENOG4107U9T Pfam:Ribonuclease_BN CFK37_02160 ENOG4105BZG amino acid carrier protein CFK37_02165 ENOG4108RAV Conserved protein CFK37_02175 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase CFK37_02180 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin CFK37_02210 ENOG4106WTF Glycosyl transferase, family 2 CFK37_02215 ENOG4106WTF Glycosyl transferase, family 2 CFK37_02245 ENOG4105K64 Glycosyl transferase, family 2 CFK37_02250 ENOG4105CSV Glutaminase CFK37_02265 ENOG4105K4I Scp-like extracellular CFK37_02275 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F CFK37_02285 ENOG4105C26 Dehydrogenase CFK37_02295 ENOG4107258 Transcriptional regulator CFK37_02305 ENOG4105C26 Dehydrogenase CFK37_02310 ENOG4105C7K acetolactate synthase CFK37_02315 ENOG4105CHM Aminotransferase CFK37_02320 ENOG4107S6Z Na H antiporter CFK37_02340 ENOG4105C8J )-transporter CFK37_02345 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase CFK37_02355 ENOG4108ZCF integral membrane protein CFK37_02375 ENOG4105C5H ABC transporter CFK37_02385 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) CFK37_02390 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) CFK37_02395 ENOG4108R6K riboflavin synthase, subunit alpha CFK37_02425 ENOG4105C7R Atpase associated with various cellular activities aaa_3 CFK37_02445 ENOG4105K6V RNA polymerase CFK37_02450 ENOG4105DVT helicase CFK37_02455 ENOG4105C34 Pseudouridine synthase CFK37_02495 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) CFK37_02500 ENOG4105HRU Glyoxalase Bleomycin resistance protein (Dioxygenase CFK37_02505 ENOG4105EC3 peptidase S51, dipeptidase E CFK37_02520 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) CFK37_02530 ENOG4105CQB FAD linked oxidase domain protein CFK37_02535 ENOG4105G6Z alkaline phosphatase CFK37_02555 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) CFK37_02565 ENOG4105C94 Transporter CFK37_02590 ENOG4105F0V Cell wall hydrolase CFK37_02610 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) CFK37_02620 ENOG4105CBD Diacylglycerol kinase CFK37_02625 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) CFK37_02630 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) CFK37_02635 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) CFK37_02645 ENOG4105C26 Dehydrogenase CFK37_02655 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) CFK37_02660 ENOG4105C4R Atp-dependent dna helicase CFK37_02665 ENOG4108RTE 35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales (By similarity) CFK37_02670 ENOG4105KGF protein, YerC YecD CFK37_02675 ENOG4108R5T secreted protein CFK37_02680 ENOG4105CPN adenine deaminase CFK37_02685 ENOG4105C12 Phosphoribosylglycinamide synthetase CFK37_02690 ENOG4105DC1 bifunctional purine biosynthesis protein purh CFK37_02695 ENOG4108V3E phosphoribosylglycinamide formyltransferase CFK37_02700 ENOG4105CXB phosphoribosylaminoimidazole synthetase CFK37_02710 ENOG4107QIK phosphoribosylformylglycinamidine synthase CFK37_02715 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I CFK37_02720 ENOG4105VR9 phosphoribosylformylglycinamidine synthase CFK37_02725 ENOG4105C8V SAICAR synthetase CFK37_02730 ENOG4105C83 adenylosuccinate lyase CFK37_02735 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit CFK37_02740 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) CFK37_02750 ENOG4105CYX Short-chain dehydrogenase reductase Sdr CFK37_02755 ENOG4108U5N UPF0316 protein CFK37_02760 ENOG4108RPX mosc domain containing protein CFK37_02765 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) CFK37_02775 ENOG4105C26 Dehydrogenase CFK37_02780 ENOG4105C7N Xanthine uracil vitamin C permease CFK37_02785 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) CFK37_02800 ENOG4105C7R Atpase associated with various cellular activities aaa_3 CFK37_02810 ENOG4108NHD germination protein CFK37_02855 ENOG4105CZN Potassium uptake protein CFK37_02860 ENOG4108QXE glycerophosphoryl diester phosphodiesterase CFK37_02865 ENOG4105RWS endonuclease I CFK37_02870 ENOG4107BMA Transglycosylase associated protein CFK37_02880 ENOG41067SE Tetr family transcriptional regulator CFK37_02895 ENOG4105C26 Dehydrogenase CFK37_02930 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) CFK37_02935 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) CFK37_02940 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) CFK37_02945 ENOG4108TYN CAAX amino terminal protease family protein CFK37_02955 ENOG4105KTU Transcriptional regulator, arsr family CFK37_02960 ENOG4105PGM cation diffusion facilitator family transporter CFK37_02990 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) CFK37_03000 ENOG4105C5H ABC transporter CFK37_03010 ENOG4105DQ6 Transposase CFK37_03015 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) CFK37_03020 ENOG410801F ribosomal-protein-alanine acetyltransferase CFK37_03025 ENOG41072GX Peptidase M22 Glycoprotease CFK37_03030 ENOG4105K8N protein family UPF0079, ATPase CFK37_03035 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) CFK37_03125 ENOG410906U SprT-like CFK37_03140 ENOG41064BQ Phosphatase CFK37_03150 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) CFK37_03155 ENOG4105WN5 stage II sporulation protein CFK37_03160 ENOG4107SGM protein serine threonine phosphatase CFK37_03165 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase CFK37_03170 ENOG4105FUA antagonist CFK37_03175 ENOG4107MMM Anti-sigma-factor antagonist CFK37_03180 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) CFK37_03195 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein CFK37_03200 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) CFK37_03205 ENOG41082V8 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) CFK37_03215 ENOG4105CKV Membrane CFK37_03220 ENOG410905X membrane-flanked domain protein CFK37_03225 ENOG4105C1J atp-dependent rna helicase CFK37_03255 ENOG41090MY MarR family Transcriptional regulator CFK37_03270 ENOG4108TM9 integral membrane protein CFK37_03275 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) CFK37_03285 ENOG41062D9 Histidine kinase CFK37_03290 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CFK37_03300 ENOG4105SZ6 Thioredoxin CFK37_03310 ENOG4105PNM synthesis protein CFK37_03315 ENOG4105EXU Membrane CFK37_03335 ENOG4108AEY RNA polymerase sigma factor CFK37_03340 ENOG4105CJ1 ABC, transporter CFK37_03345 ENOG4108TU7 Inherit from COG: (ABC) transporter CFK37_03355 ENOG4107414 GntR family transcriptional regulator CFK37_03360 ENOG4105CG3 alpha amylase, catalytic region CFK37_03375 ENOG4105DWV Homoserine O-trans-acetylase CFK37_03380 ENOG4105CI3 gtp-binding protein typa CFK37_03385 ENOG4105BZU Histidine kinase CFK37_03395 ENOG4105C0H protease CFK37_03405 ENOG4105VES Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082) CFK37_03415 ENOG4107YB6 acetyltransferase, (GNAT) family CFK37_03420 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) CFK37_03425 ENOG4107QYD Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) CFK37_03430 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase CFK37_03440 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) CFK37_03445 ENOG4105VEQ Cold shock protein CFK37_03450 ENOG4108UKZ OsmC family CFK37_03460 ENOG4105C59 p-type ATPase CFK37_03465 ENOG4105VPX protein, conserved in bacteria CFK37_03500 ENOG4107UX3 phosphatidylethanolamine N-methyltransferase CFK37_03505 ENOG4107R16 Multicopper oxidase CFK37_03510 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen CFK37_03565 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen CFK37_03590 ENOG4107QZ2 Sulfatase CFK37_03605 ENOG4107R28 alpha amylase, catalytic region CFK37_03615 ENOG4107ZQN disulfide bond CFK37_03630 ENOG4105PGM cation diffusion facilitator family transporter CFK37_03635 ENOG4105KTU Transcriptional regulator, arsr family CFK37_03645 ENOG4105UQX Mate efflux family protein CFK37_03685 ENOG4105BZU Histidine kinase CFK37_03690 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CFK37_03700 ENOG4107QIV Cytochrome c biogenesis protein CFK37_03705 ENOG4108ZRV stage ii sporulation protein p CFK37_03710 ENOG41090UD (LipO)protein CFK37_03730 ENOG4105DZR Type I site-specific deoxyribonuclease CFK37_03740 ENOG4105CVR type I restriction-modification system CFK37_03775 ENOG4105C9U ATP-dependent DNA helicase RecQ CFK37_03805 ENOG4105E4C Lytic transglycosylase catalytic CFK37_03890 ENOG4105KK4 UPF0060 membrane protein CFK37_03895 ENOG4105C3M thioredoxin reductase CFK37_03900 ENOG41085FC arsR family transcriptional regulator CFK37_03920 ENOG4108UXE Protein tyrosine phosphatase CFK37_03925 ENOG4107R5R arsenical pump membrane protein CFK37_03930 ENOG41082YX Transcriptional regulator, arsr family CFK37_03995 ENOG4105C72 UPF0176 protein CFK37_04010 ENOG4108V06 Glutathione peroxidase CFK37_04015 ENOG4107R1M Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) (By similarity) CFK37_04030 ENOG4105CYX Short-chain dehydrogenase reductase Sdr CFK37_04035 ENOG4105DWF phosphomethylpyrimidine kinase CFK37_04040 ENOG4105SXS Protein of unknown function (DUF456) CFK37_04045 ENOG4108Y1J Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) CFK37_04070 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) CFK37_04085 ENOG4105E5Q amino acid AbC transporter CFK37_04095 ENOG4105D4A Cell wall formation (By similarity) CFK37_04105 ENOG4105WD1 Membrane CFK37_04110 ENOG4107RU2 Histidinol phosphate phosphatase, HisJ family CFK37_04115 ENOG4108IQ6 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) CFK37_04120 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) CFK37_04130 ENOG4105ECC imidazole-glycerol-phosphate dehydratase CFK37_04135 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) CFK37_04140 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase CFK37_04145 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) CFK37_04150 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase CFK37_04155 ENOG4105CIH Imidazole acetol-phosphate transaminase CFK37_04165 ENOG4107ZXU DSBA oxidoreductase CFK37_04175 ENOG4105NRR Uncharacterized protein conserved in bacteria (DUF2188) CFK37_04180 ENOG41073R8 VanW family CFK37_04185 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) CFK37_04190 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase CFK37_04200 ENOG4105W1N transcriptional regulator CFK37_04205 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) CFK37_04215 ENOG4105CV8 reductase CFK37_04220 ENOG4105C5H ABC transporter CFK37_04230 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) CFK37_04245 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) CFK37_04250 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) CFK37_04255 ENOG4105KHC sulfurtransferase CFK37_04260 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) CFK37_04270 ENOG4105FBA Phospholipase Carboxylesterase CFK37_04275 ENOG4108VXD carboxy-peptidase CFK37_04285 ENOG4105E98 transcriptional regulator DeoR family CFK37_04290 ENOG4105DE4 1-phosphofructokinase CFK37_04295 ENOG4105DM4 PTS System CFK37_04305 ENOG4105C5H ABC transporter CFK37_04315 ENOG4107Y03 Nitroreductase CFK37_04320 ENOG4105CPF Cell wall formation (By similarity) CFK37_04325 ENOG4105CRQ synthase (Component I) CFK37_04330 ENOG4105DDQ anthranilate synthase CFK37_04335 ENOG4108I0Q anthranilate phosphoribosyltransferase CFK37_04345 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) CFK37_04350 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) CFK37_04355 ENOG41086D8 Transcriptional regulator CFK37_04375 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) CFK37_04380 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) CFK37_04390 ENOG4105DTD Dehydrogenase CFK37_04400 ENOG4105EEM helicase CFK37_04450 ENOG4105CZV ABC transporter CFK37_04455 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family CFK37_04470 ENOG4105C94 Transporter CFK37_04490 ENOG4105DUX Transporter CFK37_04495 ENOG4105E0M Sulfatase CFK37_04525 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) CFK37_04530 ENOG4105DUM transcriptional regulator, lysR family CFK37_04535 ENOG4105HMI Membrane CFK37_04560 ENOG4105RHY Pfam:UPF0157 CFK37_04570 ENOG4107TXC Transcriptional regulator CFK37_04620 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family CFK37_04635 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) CFK37_04640 ENOG4105CR7 Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA (By similarity) CFK37_04660 ENOG4105DR4 Methyltransferase CFK37_04675 ENOG4105VRS hydrolase family 18 CFK37_04685 ENOG4105MZG transcriptional modulator of maze toxin, mazf CFK37_04690 ENOG4105ETU transcriptional activator (TenA CFK37_04700 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) CFK37_04705 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase CFK37_04720 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) CFK37_04730 ENOG4108UW5 maltose o-acetyltransferase CFK37_04745 ENOG4105CPC Aldo Keto reductase CFK37_04755 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) CFK37_04765 ENOG4105DEN Luciferase family CFK37_04770 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase CFK37_04780 ENOG4107TS3 membrane protein, TerC CFK37_04790 ENOG4105DRR Transcriptional regulator, GntR family CFK37_04825 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A CFK37_04830 ENOG4105D9U N-acetyltransferase CFK37_04840 ENOG4105CGH 5'-nucleotidase CFK37_04850 ENOG4108UN4 phage SPO1 DNA polymerase-related protein CFK37_04855 ENOG4105CH7 arginosuccinase CFK37_04860 ENOG4105CDH Citrulline--aspartate ligase CFK37_04865 ENOG4105DBV ornithine carbamoyltransferase CFK37_04870 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain CFK37_04875 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain CFK37_04885 ENOG4105C28 cystathionine CFK37_04890 ENOG4105C28 cystathionine CFK37_04895 ENOG4107RVU D-Ala-D-Ala carboxypeptidase 3 (S13) family CFK37_04900 ENOG4105DKW ABC transporter CFK37_04915 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) CFK37_04925 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) CFK37_04930 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) CFK37_04935 ENOG4105BZU Histidine kinase CFK37_04940 ENOG4105EFI regulatoR CFK37_04945 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) CFK37_04950 ENOG4105C8B TIGR00159 family CFK37_04955 ENOG4105KXB anti-sigma factor CFK37_04960 ENOG4105EMN RNA polymerase sigma factor CFK37_04985 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) CFK37_05065 ENOG4108NMV polysaccharide deacetylase CFK37_05080 ENOG4105D1F ATP-binding protein CFK37_05115 ENOG4105D8X mechanosensitive ion channel CFK37_05135 ENOG4107QTH restriction modification system DNA specificity domain CFK37_05170 ENOG4105W5Q DNA repair protein (RadC CFK37_05215 ENOG4105XTG Pfam:DUF156 CFK37_05225 ENOG41085GJ domain protein CFK37_05230 ENOG41087NI Sulfite exporter TauE/SafE CFK37_05235 ENOG4105VFE sira family CFK37_05240 ENOG4107TPS domain protein CFK37_05245 ENOG4108ZCA Inherit from COG: pyridine nucleotide-disulfide oxidoreductase CFK37_05250 ENOG4105VFE sira family CFK37_05255 ENOG41085GJ domain protein CFK37_05260 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase CFK37_05270 ENOG4108VK3 Cupin 2 Conserved Barrel Domain Protein CFK37_05275 ENOG4107Z3H Transcriptional regulator, TetR family CFK37_05295 ENOG4108UJD 30S ribosomal protein S9 CFK37_05300 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) CFK37_05305 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) CFK37_05310 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) CFK37_05315 ENOG4108JJB ABC transporter CFK37_05320 ENOG4108JJB ABC transporter CFK37_05325 ENOG4108ZT0 50S ribosomal protein l17 CFK37_05330 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) CFK37_05335 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) CFK37_05340 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits CFK37_05345 ENOG41067V7 50S ribosomal protein L36 CFK37_05350 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) CFK37_05360 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) CFK37_05365 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) CFK37_05370 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) CFK37_05375 ENOG4105VPB 50S ribosomal protein L30 CFK37_05380 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) CFK37_05385 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) CFK37_05390 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) CFK37_05395 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) CFK37_05400 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) CFK37_05405 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits CFK37_05410 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) CFK37_05415 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) CFK37_05420 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal CFK37_05425 ENOG41082SA 50s ribosomal protein l29 CFK37_05430 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) CFK37_05435 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) CFK37_05440 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) CFK37_05445 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) CFK37_05450 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity CFK37_05455 ENOG41080UE One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) CFK37_05460 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) CFK37_05465 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) CFK37_05470 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) CFK37_05480 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) CFK37_05485 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) CFK37_05490 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) CFK37_05495 ENOG4105XPM ribosomal protein CFK37_05500 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) CFK37_05505 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) CFK37_05510 ENOG4107Y49 methyltransferase CFK37_05515 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) CFK37_05520 ENOG4108VZM 50s ribosomal protein L10 CFK37_05525 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) CFK37_05535 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) CFK37_05545 ENOG4107FTN 50S ribosomal protein L33 CFK37_05550 ENOG4105QIV RNA polymerase CFK37_05555 ENOG4105M0M Tetracycline resistance protein CFK37_05560 ENOG4105C2N RNA methyltransferase TrmH family group 3 CFK37_05570 ENOG4105C8N cysteinyl-tRNA synthetase CFK37_05575 ENOG4105D7W serine acetyltransferase CFK37_05580 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) CFK37_05585 ENOG4105CTP PilT protein domain protein CFK37_05590 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) CFK37_05595 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit CFK37_05600 ENOG41066A3 ATP guanido phosphotransferase CFK37_05605 ENOG4108Z0C Uvrb UvrC protein CFK37_05615 ENOG4105KT7 mgtC SapB transporter CFK37_05695 ENOG4105CRK lysyL-tRNA synthetase CFK37_05705 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase CFK37_05710 ENOG4105KRF dihydroneopterin aldolase CFK37_05715 ENOG4105EEI dihydropteroate synthase CFK37_05720 ENOG4105C6T cysteine synthase CFK37_05725 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) CFK37_05730 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) CFK37_05735 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) CFK37_05740 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) CFK37_05745 ENOG4108UGV hypoxanthine phosphoribosyltransferase CFK37_05750 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) CFK37_05775 ENOG4105C0R drug resistance transporter emrb qaca subfamily CFK37_05785 ENOG41060GV RNA binding s1 domain protein CFK37_05800 ENOG4105VYY sporulation protein yabp CFK37_05805 ENOG41082I2 s4 domain protein CFK37_05810 ENOG4108IY2 MazG family CFK37_05820 ENOG4108M14 stage v sporulation protein t CFK37_05825 ENOG4108JA2 transcriptioN-repair coupling factor CFK37_05835 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) CFK37_05840 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) CFK37_05845 ENOG4105C5T Phosphoribosyl pyrophosphate synthase CFK37_05850 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) CFK37_05855 ENOG4105K4W Could be involved in septation (By similarity) CFK37_05860 ENOG4105DFT pur operon repressor CFK37_05865 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) CFK37_05885 ENOG4105W42 Veg protein CFK37_05890 ENOG4105XFA sporulation peptidase YabG CFK37_05895 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) CFK37_05905 ENOG41069ER domain protein CFK37_05920 ENOG4105KRN Transcriptional regulator, abrb family CFK37_05925 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) CFK37_05930 ENOG4105VC4 domain protein CFK37_05935 ENOG41060K3 Methyltransferase CFK37_05940 ENOG4105QD5 Involved in initiation control of chromosome replication (By similarity) CFK37_05945 ENOG4105MA4 psp1 domain protein CFK37_05950 ENOG4105FA2 dna polymerase iii CFK37_05955 ENOG4105X0R protein from nitrogen regulatory protein P-II CFK37_05960 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) CFK37_05965 ENOG4105CXN decarboxylase CFK37_05970 ENOG41076HS cation diffusion facilitator family transporter CFK37_05980 ENOG41067KS pro-sigma K processing CFK37_05990 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) CFK37_05995 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) CFK37_06000 ENOG4105C6E dna polymerase iii CFK37_06010 ENOG4108Z6B deaminase CFK37_06015 ENOG4105GTG Isochorismatase CFK37_06020 ENOG4105VRS hydrolase family 18 CFK37_06025 ENOG4107RKG DJ-1/PfpI family CFK37_06045 ENOG4105ZMH deoxynucleoside kinase CFK37_06050 ENOG4105II7 pyrroline-5-carboxylate reductase CFK37_06075 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) CFK37_06080 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) CFK37_06085 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) CFK37_06095 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) CFK37_06110 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) CFK37_06115 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) CFK37_06125 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) CFK37_06130 ENOG410848D S4 domain protein YaaA CFK37_06135 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) CFK37_06140 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) CFK37_06145 ENOG4105VG0 50S ribosomal protein l34 CFK37_06150 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) CFK37_06155 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins CFK37_06165 ENOG4105IIU Aminopeptidase CFK37_06170 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) CFK37_06175 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) CFK37_06180 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) CFK37_06185 ENOG410636K Effects nucleoid occlusion by binding relatively nonspecifically to DNA and preventing the assembly of the division machinery in the vicinity of the nucleoid, especially under conditions that disturb the cell cycle. It helps to coordinate cell division and chromosome segregation by preventing the formation of the Z ring through the nucleoid, which would cause chromosome breakage (By similarity) CFK37_06190 ENOG4107QJE Chromosome Partitioning Protein CFK37_06195 ENOG4105FA0 parb-like partition protein CFK37_06200 ENOG4105C9B Cysteine desulfurase CFK37_06210 ENOG4108ZDA Sporulation protein YyaC CFK37_06220 ENOG4105D8X mechanosensitive ion channel CFK37_06225 ENOG4105VDK protein, conserved in bacteria CFK37_06230 ENOG4105C3G gtp-binding protein CFK37_06235 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) CFK37_06240 ENOG4108UUM single-stranded DNA-binding protein CFK37_06245 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) CFK37_06265 ENOG4105E0C molybdate abc transporter CFK37_06270 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein CFK37_06285 ENOG4105BZR domain protein CFK37_06290 ENOG4105K9Q Binds to the 23S rRNA (By similarity) CFK37_06295 ENOG4105CDU Replicative dna helicase CFK37_06300 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis CFK37_06305 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CFK37_06310 ENOG4105BZU Histidine kinase CFK37_06325 ENOG4105Q2H domain protein CFK37_06330 ENOG4105C0H protease CFK37_06335 ENOG4105K56 Transcriptional regulator CFK37_06340 ENOG4105CJ1 ABC, transporter CFK37_06390 ENOG4105DHS permease protein CFK37_06395 ENOG4105CM4 permease protein CFK37_06400 ENOG4108IPW abc transporter atp-binding protein CFK37_06410 ENOG4105KZX Pterin carbinolamine dehydratase CFK37_06430 ENOG41061AU MarR family Transcriptional regulator CFK37_06440 ENOG4105DXB Major Facilitator superfamily CFK37_06485 ENOG4107QJE Chromosome Partitioning Protein CFK37_06510 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) CFK37_06525 ENOG4105DWT malate dehydrogenase (quinone) CFK37_06535 ENOG4105CIG ABC transporter CFK37_06550 ENOG4105P8F nudix hydrolase CFK37_06565 ENOG4105CMU LysR family (Transcriptional regulator CFK37_06570 ENOG4108S4H thioesterase Superfamily protein CFK37_06590 ENOG4108WBT adenosyltransferase CFK37_06605 ENOG4107XPA Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) CFK37_06610 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) CFK37_06615 ENOG4108YZT Adenosylcobinamide kinase CFK37_06620 ENOG4107QZB decarboxylase CFK37_06625 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) CFK37_06630 ENOG4105E0A ABC, transporter CFK37_06635 ENOG4105EHG Permease protein CFK37_06640 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) CFK37_06645 ENOG4105CHR reductase CFK37_06655 ENOG4105K7K Transcriptional regulator CFK37_06670 ENOG4105D82 Glutamate dehydrogenase CFK37_06675 ENOG4108UB7 CFK37_06685 ENOG4108W7F transporter, permease CFK37_06690 ENOG4108JJB ABC transporter CFK37_06695 ENOG4105NSK ABC superfamily ATP binding cassette transporter membrane protein CFK37_06700 ENOG4108X43 YKOF domain protein CFK37_06715 ENOG4105CYN Serine protein kinase CFK37_06720 ENOG4106AKX UPF0229 protein CFK37_06735 ENOG4105ED1 spovr family CFK37_06745 ENOG4105EUB pirin domain protein CFK37_06750 ENOG4105KVH Transcriptional regulator CFK37_06770 ENOG4105CQB FAD linked oxidase domain protein CFK37_06775 ENOG4105DWD nucleoside recognition domain protein CFK37_06780 ENOG4108JPW Aminotransferase CFK37_06805 ENOG4105C0R drug resistance transporter emrb qaca subfamily CFK37_06820 ENOG4105DE9 3-keto-5-aminohexanoate cleavage enzyme CFK37_06825 ENOG4107HG4 Transcriptional regulator CFK37_06830 ENOG4108IJ8 ABC transporter CFK37_06835 ENOG4105E90 ABC transporter CFK37_06840 ENOG4108HQR Glycine betaine CFK37_06845 ENOG4105R40 Glycine betaine carnitine choline CFK37_06865 ENOG4105XTG Pfam:DUF156 CFK37_06870 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase CFK37_06875 ENOG41085GJ domain protein CFK37_06880 ENOG4107TPS domain protein CFK37_06885 ENOG4105VFE sira family CFK37_06890 ENOG41087NI Sulfite exporter TauE/SafE CFK37_06895 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) CFK37_06930 ENOG4105JVQ RNA Polymerase CFK37_06935 ENOG4108P49 AntiSigma factor CFK37_06940 ENOG4107VMI polysaccharide deacetylase CFK37_06950 ENOG4107G87 m6 family metalloprotease domain protein CFK37_06955 ENOG4108JYZ YitT family CFK37_06975 ENOG4105BZ1 (ABC) transporter CFK37_06985 ENOG4107U9T Pfam:Ribonuclease_BN CFK37_06995 ENOG41080UX Methyltransferase CFK37_07010 ENOG4105ECK Fatty Acid Desaturase CFK37_07015 ENOG4108ZGX Histidine kinase CFK37_07020 ENOG4108S01 response regulator CFK37_07025 ENOG4105DEN Luciferase family CFK37_07035 ENOG4105CS1 NAD(P)H quinone oxidoreductase CFK37_07050 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs CFK37_07085 ENOG4105CH6 catalase CFK37_07100 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) CFK37_07110 ENOG4107S6Z Na H antiporter CFK37_07115 ENOG4105C02 permease CFK37_07120 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) CFK37_07125 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) CFK37_07135 ENOG4105C94 Transporter CFK37_07140 ENOG4105DZS Phenylacetate-CoA ligase CFK37_07145 ENOG4108Z0R Transferase CFK37_07155 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit CFK37_07170 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit CFK37_07180 ENOG4105E39 Enoyl-CoA hydratase CFK37_07185 ENOG4108UKI Enoyl-CoA hydratase CFK37_07190 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase CFK37_07195 ENOG4105CHU acetyl-coa acetyltransferase CFK37_07200 ENOG4105E39 Enoyl-CoA hydratase CFK37_07205 ENOG4105EA8 2-Nitropropane dioxygenase CFK37_07220 ENOG4105C7J ABC transporter, permease CFK37_07225 ENOG4108JJB ABC transporter CFK37_07230 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase CFK37_07235 ENOG4105DV0 amidase (EC 3.5.1.4 CFK37_07240 ENOG4105KWG Pfam:DUF1696 CFK37_07250 ENOG4105CMG Carbohydrate kinase CFK37_07260 ENOG4105CZM Major Facilitator CFK37_07290 ENOG4105EA8 2-Nitropropane dioxygenase CFK37_07295 ENOG4105K4H Nlp p60 protein CFK37_07300 ENOG4105KME endoribonuclease L-psp CFK37_07305 ENOG4107QW4 alcohol dehydrogenase CFK37_07325 ENOG4105PTM secreted protein CFK37_07330 ENOG4105C0R drug resistance transporter emrb qaca subfamily CFK37_07335 ENOG4108J59 Extracellular solute-binding protein, family 5 CFK37_07350 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component CFK37_07355 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component CFK37_07365 ENOG4108JQ7 (ABC) transporter CFK37_07370 ENOG41069ER domain protein CFK37_07375 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) CFK37_07380 ENOG4105EXW epimerase dehydratase CFK37_07385 ENOG4105C5H ABC transporter CFK37_07405 ENOG41090WU lipolytic protein G-D-S-L family CFK37_07410 ENOG4105FR1 rard protein CFK37_07415 ENOG4105C28 cystathionine CFK37_07425 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) CFK37_07430 ENOG4108S4H thioesterase Superfamily protein CFK37_07440 ENOG4105DFD Na H antiporter CFK37_07455 ENOG4105CGP Urocanate hydratase CFK37_07460 ENOG4105CI2 imidazolone-5-propionate hydrolase CFK37_07465 ENOG4108903 Formimidoylglutamase CFK37_07470 ENOG4105KVH Transcriptional regulator CFK37_07485 ENOG4105C9U ATP-dependent DNA helicase RecQ CFK37_07530 ENOG4108X3M OsmC Ohr family protein CFK37_07540 ENOG4108TGC Acyltransferase CFK37_07550 ENOG4105DWD nucleoside recognition domain protein CFK37_07570 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) CFK37_07575 ENOG4105BZ9 Cytochrome C oxidase, subunit I CFK37_07585 ENOG4105CBC glutamate synthase CFK37_07595 ENOG4105M08 Membrane CFK37_07610 ENOG4108VKI Cell wall hydrolase CFK37_07615 ENOG4107JTW chlorite dismutase CFK37_07620 ENOG4108IJ2 phosphate acetyltransferase CFK37_07625 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) CFK37_07630 ENOG4105DCI Phosphohydrolase CFK37_07645 ENOG4108XFG YwhD family CFK37_07650 ENOG4105BZ4 penicillin-binding protein CFK37_07655 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) CFK37_07670 ENOG4105VFR signal peptidase CFK37_07685 ENOG4105C75 arginyL-tRNA synthetase CFK37_07700 ENOG4105DF6 Fe-S oxidoreductase CFK37_07710 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase CFK37_07715 ENOG4105C1G acyl-Coa dehydrogenase CFK37_07720 ENOG4105C1G acyl-Coa dehydrogenase CFK37_07735 ENOG4105D5P Methylmalonyl-coA mutase CFK37_07740 ENOG4108Z1Y Participates in both the initiation and recycling phases of transcription. In the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling (By similarity) CFK37_07745 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) CFK37_07750 ENOG410812K response regulator receiver protein CFK37_07755 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) CFK37_07760 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) CFK37_07765 ENOG4105CBT Fructose-1,6-bisphosphatase CFK37_07770 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) CFK37_07775 ENOG41082DI 50s ribosomal protein l31 CFK37_07780 ENOG4107104 thymidine kinase CFK37_07785 ENOG4105CBC glutamate synthase CFK37_07790 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) CFK37_07795 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) CFK37_07800 ENOG4108ZXQ stage ii sporulation protein r CFK37_07810 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) CFK37_07815 ENOG410815N Probably functions as a manganese efflux pump (By similarity) CFK37_07820 ENOG4107WAU Protein tyrosine phosphatase CFK37_07825 ENOG4108YZG isomerase CFK37_07830 ENOG4108UIC UPF0340 protein CFK37_07835 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) CFK37_07840 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) CFK37_07845 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase CFK37_07850 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin CFK37_07865 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) CFK37_07870 ENOG4105WS6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) CFK37_07875 ENOG4107ZFM Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) CFK37_07880 ENOG4107YZM F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) CFK37_07885 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) CFK37_07890 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) CFK37_07895 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) CFK37_07900 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) CFK37_07920 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) CFK37_07925 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A CFK37_07930 ENOG4107SN7 NLP P60 protein CFK37_07940 ENOG4105FRN stage II sporulation protein CFK37_07960 ENOG4105DFF Rod shape-determining protein mreb CFK37_07970 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) CFK37_07990 ENOG4105MRC Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth CFK37_08005 ENOG4105MRC Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth CFK37_08035 ENOG4107ETC gas vesicle protein CFK37_08040 ENOG4108XNA Gas vesicle CFK37_08045 ENOG4105W2E Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth (By similarity) CFK37_08100 ENOG4105CJ1 ABC, transporter CFK37_08110 ENOG4107Z3H Transcriptional regulator, TetR family CFK37_08115 ENOG4105ESV Glycosyl transferase, family 4 CFK37_08130 ENOG4105CUB amino acid CFK37_08135 ENOG4105ESV Glycosyl transferase, family 4 CFK37_08155 ENOG4105CKP Polysaccharide Biosynthesis Protein CFK37_08170 ENOG4107RZX Teichoic acid biosynthesis protein CFK37_08175 ENOG4107ZIC Glycerol-3-phosphate cytidylyltransferase CFK37_08180 ENOG4108FQ0 the rest of the oligosaccharide is released intact. Cleaves the peptidoglycan connecting the daughter cells at the end of the cell division cycle, resulting in the separation of the two newly divided cells. Acts as an autolysin in penicillin-induced lysis CFK37_08185 ENOG4108NMT An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon (By similarity) CFK37_08190 ENOG4107SJB teichoic acid biosynthesis CFK37_08200 ENOG4105EY8 ABC transporter CFK37_08210 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) CFK37_08215 ENOG4105CEY Amp-dependent synthetase and ligase CFK37_08225 ENOG4107YCY Transcriptional regulator CFK37_08235 ENOG4105D5U fad dependent oxidoreductase CFK37_08250 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component CFK37_08255 ENOG4105DEF Extracellular solute-binding protein, family 5 CFK37_08260 ENOG4105C3U ABC transporter CFK37_08265 ENOG4108JQ7 (ABC) transporter CFK37_08285 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) CFK37_08290 ENOG4105FGV Chromate CFK37_08295 ENOG4105FGV Chromate CFK37_08305 ENOG4105CJR Integral membrane protein (MviN CFK37_08315 ENOG4105W2C Glycosyl transferase CFK37_08320 ENOG4105ESV Glycosyl transferase, family 4 CFK37_08325 ENOG4108KGH TRANSCRIPTIONal CFK37_08330 ENOG4108QXE glycerophosphoryl diester phosphodiesterase CFK37_08345 ENOG4107QYE Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) CFK37_08350 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) CFK37_08360 ENOG4107RIQ Sulfate adenylate transferase CFK37_08365 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) CFK37_08370 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) CFK37_08375 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) CFK37_08380 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) CFK37_08385 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein CFK37_08390 ENOG4108Z73 Siroheme synthase CFK37_08410 ENOG4105E2R ROK family CFK37_08415 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) CFK37_08420 ENOG4105CKN UDP-glucose-hexose-1-phosphate uridylyltransferase CFK37_08425 ENOG4105CMR udp-glucose 4-epimerase CFK37_08430 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) CFK37_08435 ENOG4107QNK )-transporter CFK37_08465 ENOG4105DKQ ROK family CFK37_08470 ENOG4105XN3 extracellular solute-binding protein family 1 CFK37_08475 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component CFK37_08485 ENOG4105CK5 oxidoreductase CFK37_08500 ENOG4105E6M Sulphatase-modifying factor protein CFK37_08520 ENOG4105ESP cell wall surface anchor family protein CFK37_08555 ENOG4105W4W Transcriptional regulator CFK37_08570 ENOG41075H3 AraC family transcriptional regulator CFK37_08580 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component CFK37_08595 ENOG4105C8I hydrolase, family 38 CFK37_08635 ENOG4107VG4 Xylose isomerase domain protein TIM barrel CFK37_08640 ENOG4105CK5 oxidoreductase CFK37_08645 ENOG4105CBG Sulfatase CFK37_08655 ENOG4105CNT hydrolase family 2 CFK37_08685 ENOG4108X79 transcriptional regulator CFK37_08690 ENOG4105E70 isomerase CFK37_08695 ENOG4105CE4 GlcNAc 6-P deacetylase CFK37_08700 ENOG4105DE4 1-phosphofructokinase CFK37_08715 ENOG4105D9U N-acetyltransferase CFK37_08725 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) CFK37_08760 ENOG4105DNP FAD linked oxidase domain protein CFK37_08810 ENOG4106A2Z transcriptional regulator antitoxin, MazE CFK37_08815 ENOG4105MZG transcriptional modulator of maze toxin, mazf CFK37_08825 ENOG4105CZM Major Facilitator CFK37_08830 ENOG4107MII Sugar-specific transcriptional regulator TrmB CFK37_08835 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) CFK37_08845 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase CFK37_08865 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) CFK37_08870 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) CFK37_08890 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase CFK37_08895 ENOG4105KVH Transcriptional regulator CFK37_08935 ENOG4105HTX biosynthesis protein CFK37_08940 ENOG4107YJ4 chain length determinant protein CFK37_08945 ENOG4108RB3 Capsular polysaccharide biosynthesis protein CFK37_08950 ENOG4108RB3 Capsular polysaccharide biosynthesis protein CFK37_08980 ENOG4108UW5 maltose o-acetyltransferase CFK37_09005 ENOG4105D3Q Sugar transferase CFK37_09010 ENOG4105MME Sugar o-acyltransferase, sialic acid o-acetyltransferase neud family CFK37_09015 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase CFK37_09020 ENOG4108KGH TRANSCRIPTIONal CFK37_09060 ENOG4105CI2 imidazolone-5-propionate hydrolase CFK37_09075 ENOG4105C2F Histidine kinase CFK37_09080 ENOG4108VAC response regulator CFK37_09085 ENOG4107R5U Periplasmic binding protein LacI transcriptional regulator CFK37_09090 ENOG4105C2J ABC transporter CFK37_09095 ENOG4107R9N ABC transporter CFK37_09100 ENOG41062B0 ABC transporter, permease CFK37_09105 ENOG4105CNT hydrolase family 2 CFK37_09110 ENOG4105CUK Alpha-N-arabinofuranosidase (EC 3.2.1.55) CFK37_09140 ENOG4105C6F GntR Family Transcriptional Regulator CFK37_09150 ENOG4108IA2 Sodium pantothenate symporter CFK37_09160 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) CFK37_09170 ENOG4105C26 Dehydrogenase CFK37_09175 ENOG4108WYP Transcriptional regulator CFK37_09200 ENOG4105EYF MMPL domain protein CFK37_09210 ENOG4105D17 glycoside hydrolase, family 3 domain protein CFK37_09220 ENOG4105EHZ conserved protein UCP016719 CFK37_09230 ENOG4107S1E Beta-lactamase CFK37_09240 ENOG4108JUB Transcriptional regulator CFK37_09245 ENOG4105DEF Extracellular solute-binding protein, family 5 CFK37_09250 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component CFK37_09255 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component CFK37_09260 ENOG4105C3U ABC transporter CFK37_09265 ENOG4108JQ7 (ABC) transporter CFK37_09275 ENOG4108ME1 Peptidase M55 D-aminopeptidase CFK37_09295 ENOG4105C83 adenylosuccinate lyase CFK37_09300 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) CFK37_09305 ENOG4105DFD Na H antiporter CFK37_09310 ENOG4105C26 Dehydrogenase CFK37_09315 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) CFK37_09325 ENOG4105CTU Proline racemase CFK37_09335 ENOG4108JUB Transcriptional regulator CFK37_09360 ENOG4105DWV Homoserine O-trans-acetylase CFK37_09365 ENOG4107V2S Transcriptional regulator CFK37_09370 ENOG4108URH decarboxylase CFK37_09380 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) CFK37_09385 ENOG4105C26 Dehydrogenase CFK37_09395 ENOG4105TRT Transcriptional regulator CFK37_09405 ENOG4105R8C Transcriptional regulator CFK37_09455 ENOG4105IIP Membrane CFK37_09460 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) CFK37_09465 ENOG4107SKW Inherit from COG: Alpha beta hydrolase CFK37_09490 ENOG4105CD5 CoA-binding domain protein CFK37_09495 ENOG410900P UPF0336 protein CFK37_09515 ENOG4105CC9 acyl-Coa dehydrogenase CFK37_09520 ENOG4105C1G acyl-Coa dehydrogenase CFK37_09525 ENOG4105C26 Dehydrogenase CFK37_09530 ENOG4105C0R drug resistance transporter emrb qaca subfamily CFK37_09565 ENOG4105CH2 amidohydrolase CFK37_09570 ENOG4105CFC Transporter CFK37_09575 ENOG4107RT5 aminobenzoyl-glutamate utilization protein B CFK37_09580 ENOG4105CE7 Amidase, hydantoinase carbamoylase family CFK37_09590 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) CFK37_09620 ENOG4105CSH Transporter CFK37_09635 ENOG4105CK7 Sodium proline symporter CFK37_09655 ENOG4105K4H Nlp p60 protein CFK37_09665 ENOG4105CAX The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity) CFK37_09670 ENOG4107S2N Type III effector Hrp-dependent CFK37_09675 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) CFK37_09680 ENOG410901P UPF0249 protein CFK37_09685 ENOG4108X79 transcriptional regulator CFK37_09690 ENOG4105F8D glycoside hydrolase family 4 CFK37_09700 ENOG4105CK1 PTS System CFK37_09705 ENOG4105VCP PTS System CFK37_09710 ENOG4105CS2 ec 3.2.1.21 CFK37_09725 ENOG4107W7X Aldolase CFK37_09730 ENOG4105FDP GntR family transcriptional regulator CFK37_09735 ENOG4107VFR oxidoreductase CFK37_09770 ENOG4105KHC sulfurtransferase CFK37_09780 ENOG4105CGH 5'-nucleotidase CFK37_09790 ENOG4105D3W isochorismatase CFK37_09800 ENOG41081VK Ribonuclease CFK37_09810 ENOG4105P4J Allophanate hydrolase, subunit 1 CFK37_09820 ENOG4105E7W lamb ycsf family protein CFK37_09825 ENOG4105C5A transporter CFK37_09830 ENOG4105CFM UPF0317 protein CFK37_09835 ENOG4105DFD Na H antiporter CFK37_09840 ENOG4105DYB Isoaspartyl dipeptidase CFK37_09845 ENOG4105C6Z Gluconate CFK37_09855 ENOG4108JUB Transcriptional regulator CFK37_09865 ENOG4105E39 Enoyl-CoA hydratase CFK37_09870 ENOG4108IA2 Sodium pantothenate symporter CFK37_09880 ENOG4105CE7 Amidase, hydantoinase carbamoylase family CFK37_09890 ENOG4107SJI Dehydrogenase CFK37_09910 ENOG4105G9B Transcriptional regulator CFK37_09915 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) CFK37_09920 ENOG4105C26 Dehydrogenase CFK37_09925 ENOG4105CK7 Sodium proline symporter CFK37_09975 ENOG4105DAA L-lactate CFK37_09980 ENOG4105JXH GntR family transcriptional regulator CFK37_09985 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) CFK37_09990 ENOG4107QR9 Iron-sulfur cluster binding protein CFK37_10000 ENOG4105CMU LysR family (Transcriptional regulator CFK37_10005 ENOG4105C82 Malate synthase CFK37_10010 ENOG4108KWP DNA-binding transcriptional regulator GlcC CFK37_10015 ENOG4105CQB FAD linked oxidase domain protein CFK37_10020 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) CFK37_10025 ENOG4105CQB FAD linked oxidase domain protein CFK37_10030 ENOG4105ERH Fumarylacetoacetate hydrolase CFK37_10035 ENOG4105DAA L-lactate CFK37_10040 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) CFK37_10055 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) CFK37_10060 ENOG4105CTZ aminopeptidase c CFK37_10095 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) CFK37_10100 ENOG4105DGU Histone deacetylase CFK37_10110 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) CFK37_10115 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) CFK37_10120 ENOG4105C6T cysteine synthase CFK37_10130 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component CFK37_10140 ENOG4108RVA ribokinase CFK37_10150 ENOG41066VF YeeE YedE family protein CFK37_10175 ENOG4105DY9 regulatoR CFK37_10180 ENOG4108HRK Histidine kinase CFK37_10195 ENOG4106KNT transcriptional regulator CFK37_10200 ENOG4105D7K pfkb domain protein CFK37_10205 ENOG4108UHU Aldolase CFK37_10210 ENOG4105CXK mandelate racemase muconate lactonizing CFK37_10215 ENOG4105C6Z Gluconate CFK37_10220 ENOG4105E1V na solute symporter CFK37_10230 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) CFK37_10240 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase CFK37_10245 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F CFK37_10250 ENOG4105DRR Transcriptional regulator, GntR family CFK37_10260 ENOG4105DG6 mannose-6-phosphate isomerase CFK37_10270 ENOG4105C2F Histidine kinase CFK37_10275 ENOG4105EQD regulatoR CFK37_10285 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component CFK37_10295 ENOG4105EVU fructokinase CFK37_10305 ENOG4105ETD TRANSCRIPTIONal CFK37_10315 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase CFK37_10340 ENOG4105EW6 flavin reductase domain protein, FMN-binding CFK37_10345 ENOG4105DC7 peptidase M24 CFK37_10350 ENOG4105E2R ROK family CFK37_10355 ENOG4105C4Y ABC transporter CFK37_10360 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) CFK37_10370 ENOG4106IQC argininosuccinate lyase CFK37_10385 ENOG4108K8K Transcriptional regulator CFK37_10390 ENOG4105DCF alanine dehydrogenase CFK37_10405 ENOG4108MRH transcriptional regulatory protein CFK37_10415 ENOG4105YWU small acid-soluble spore protein CFK37_10420 ENOG4108NZE NAGC-like transcriptional regulator CFK37_10435 ENOG4106N3A copper homeostasis protein cutc CFK37_10440 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) CFK37_10445 ENOG4107ZAE 6-carboxy-5,6,7,8-tetrahydropterin synthase CFK37_10450 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) CFK37_10455 ENOG4106ETB IIa component CFK37_10460 ENOG41082GB PTS system galactitol-specific transporter subunit IIA CFK37_10465 ENOG4105K18 The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) CFK37_10470 ENOG4105DT3 PTS system, galactitol-specific IIc component CFK37_10475 ENOG4105CPQ Dehydrogenase CFK37_10480 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) CFK37_10485 ENOG4107WTH Galactitol-1-phosphate dehydrogenase CFK37_10490 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CFK37_10500 ENOG4105FDP GntR family transcriptional regulator CFK37_10505 ENOG4105DCF alanine dehydrogenase CFK37_10510 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) CFK37_10525 ENOG4105CN9 Peptidase m42 family protein CFK37_10555 ENOG4108Z86 Glutamine amidotransferase CFK37_10565 ENOG4105ERH Fumarylacetoacetate hydrolase CFK37_10575 ENOG4105FDT acyl-CoA dehydrogenase CFK37_10600 ENOG4105ETE Transcriptional regulator (LacI family CFK37_10605 ENOG4108PSK reductase CFK37_10610 ENOG4107T3P ABC, transporter CFK37_10615 ENOG4107T3P ABC, transporter CFK37_10635 ENOG4107RJ5 oxidoreductase CFK37_10650 ENOG4105CK5 oxidoreductase CFK37_10655 ENOG4107QP6 Xylose isomerase domain protein TIM barrel CFK37_10680 ENOG4108IYU L-aspartate oxidase CFK37_10685 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase CFK37_10690 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) CFK37_10695 ENOG4107S9D Alpha beta hydrolase CFK37_10710 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase CFK37_10715 ENOG41060GT Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) CFK37_10725 ENOG4105CKK Glycosyl transferase, family 2 CFK37_10730 ENOG4105C1B dTDP-glucose 4-6-dehydratase CFK37_10735 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) CFK37_10750 ENOG4105DWD nucleoside recognition domain protein CFK37_10775 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) CFK37_10780 ENOG4105CMT Dihydroxyacetone kinase CFK37_10785 ENOG4108UTZ Dihydroxyacetone kinase CFK37_10790 ENOG4105VDH Dihydroxyacetone kinase CFK37_10800 ENOG4108X4Q Hydrolase CFK37_10830 ENOG4108VX5 3-methyladenine DNA glycosylase CFK37_10835 ENOG4105CDA abc transporter atp-binding protein CFK37_10840 ENOG4105DRP amino acid AbC transporter CFK37_10850 ENOG4105QNR S1 RNA binding domain protein CFK37_10865 ENOG4108Z4U Ferredoxin CFK37_10880 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) CFK37_10885 ENOG4105C26 Dehydrogenase CFK37_10915 ENOG4105CPP Dehydrogenase, E1 component CFK37_10930 ENOG4105DFD Na H antiporter CFK37_10935 ENOG4105ERH Fumarylacetoacetate hydrolase CFK37_10950 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase CFK37_10955 ENOG4107XZQ multidrug resistance protein CFK37_10960 ENOG4105CHR reductase CFK37_10995 ENOG4108IUE nitrate reductase beta subunit CFK37_11020 ENOG4105KPV Transcriptional regulator CFK37_11025 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) CFK37_11030 ENOG4107V6Q Cyclic nucleotide-binding domain CFK37_11040 ENOG41067MG lrgb family CFK37_11050 ENOG4105C9U ATP-dependent DNA helicase RecQ CFK37_11060 ENOG4108MRH transcriptional regulatory protein CFK37_11080 ENOG4107EFR Flavocytochrome c CFK37_11095 ENOG4107PBV potassium channel CFK37_11110 ENOG4105EFZ amidohydrolase CFK37_11135 ENOG4105EG2 ABC transporter, permease CFK37_11145 ENOG4105FKQ transcriptional regulator CFK37_11160 ENOG4105DTQ mandelate racemase muconate lactonizing CFK37_11165 ENOG4108Q5Y Membrane CFK37_11170 ENOG4105CRW Short chain fatty acid transporter CFK37_11175 ENOG4105RD7 BadF BadG BcrA BcrD CFK37_11185 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate CFK37_11195 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component CFK37_11200 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component CFK37_11215 ENOG4105CK7 Sodium proline symporter CFK37_11220 ENOG4105CYW agmatinase CFK37_11230 ENOG4108S01 response regulator CFK37_11260 ENOG4105DJ2 Major Facilitator Superfamily CFK37_11265 ENOG4105D94 Major Facilitator Superfamily CFK37_11270 ENOG4107SJW iron permease, FTR1 CFK37_11275 ENOG410650H (LipO)protein CFK37_11280 ENOG4105DBE peroxidase CFK37_11300 ENOG4107F3J Amp-dependent synthetase and ligase CFK37_11305 ENOG4107ZYJ bioY protein CFK37_11310 ENOG4105C8P )-transporter CFK37_11320 ENOG410605W Major Facilitator CFK37_11330 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) CFK37_11355 ENOG4108JPW Aminotransferase CFK37_11360 ENOG4105C26 Dehydrogenase CFK37_11380 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) CFK37_11385 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) CFK37_11395 ENOG4105C26 Dehydrogenase CFK37_11405 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase CFK37_11420 ENOG4107RVG penicillin-binding protein CFK37_11425 ENOG4108KGH TRANSCRIPTIONal CFK37_11435 ENOG4108IMY Transcriptional regulator CFK37_11440 ENOG4108SU4 UPF0309 protein CFK37_11450 ENOG4105CI1 PTS System CFK37_11455 ENOG4105FDP GntR family transcriptional regulator CFK37_11460 ENOG4105CE4 GlcNAc 6-P deacetylase CFK37_11465 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) CFK37_11470 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein CFK37_11480 ENOG4105WH1 Two component transcriptional regulator luxr family CFK37_11495 ENOG41081UC Inherit from COG: Competence protein CFK37_11505 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving CFK37_11510 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) CFK37_11520 ENOG4105CAK Cell division ATP-binding protein ftsE CFK37_11525 ENOG4105CRP Part of the ABC transporter FtsEX involved in CFK37_11530 ENOG4105DR5 peptidase CFK37_11535 ENOG4105CN1 protease CFK37_11545 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) CFK37_11550 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) CFK37_11560 ENOG4108TN2 lmbE family CFK37_11565 ENOG41067S9 phage shock protein C, PspC CFK37_11570 ENOG41086DT Membrane protein of unknown function CFK37_11575 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) CFK37_11580 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) CFK37_11585 ENOG4105HKU nucleoside recognition domain-containing protein CFK37_11590 ENOG4107XGZ Hydrolase CFK37_11595 ENOG4108S4C acetyltransferase CFK37_11600 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator CFK37_11605 ENOG4105C6V Glycerol-3-phosphate dehydrogenase CFK37_11615 ENOG4105C3M thioredoxin reductase CFK37_11620 ENOG4108Z4K mutator MutT protein CFK37_11625 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) CFK37_11630 ENOG4105CHW UPF0052 protein CFK37_11635 ENOG4105CIE May be required for sporulation (By similarity) CFK37_11640 ENOG4105KRI phosphocarrier protein (HPr CFK37_11645 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) CFK37_11680 ENOG4105BZA Phosphoglycerate kinase CFK37_11685 ENOG4105CP7 Triose-phosphate isomerase CFK37_11690 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) CFK37_11695 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) CFK37_11720 ENOG4105XZU Preprotein translocase, subunit SecG CFK37_11730 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) CFK37_11735 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) CFK37_11750 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) CFK37_11755 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) CFK37_11760 ENOG4105DER m42 family CFK37_11765 ENOG4105PF9 Transcriptional regulator CFK37_11775 ENOG4105DEN Luciferase family CFK37_11790 ENOG4107T5V SNARE associated Golgi CFK37_11795 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) CFK37_11800 ENOG41090UD (LipO)protein CFK37_11805 ENOG4105VPX protein, conserved in bacteria CFK37_11810 ENOG4105C59 p-type ATPase CFK37_11820 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) CFK37_11840 ENOG4105ENE Histidine kinase CFK37_11845 ENOG4105WH1 Two component transcriptional regulator luxr family CFK37_11855 ENOG4108V3A UPF0421 protein CFK37_11860 ENOG4105D7N magnesium and cobalt transport protein CorA CFK37_11865 ENOG4105Z8B NlpC/P60 family CFK37_11870 ENOG4105E7Q Cob(II)yrinic acid a,c-diamide reductase CFK37_11880 ENOG4108JYZ YitT family CFK37_11885 ENOG410839T multidrug resistance protein CFK37_11890 ENOG41080TC multidrug resistance protein CFK37_11895 ENOG4105WMR Protein CrcB homolog CFK37_11900 ENOG4105WMR Protein CrcB homolog CFK37_11905 ENOG4105N80 Ferric uptake regulator, Fur family CFK37_11915 ENOG4105FDK ABC transporter CFK37_11925 ENOG41082MP copper ion binding protein CFK37_11930 ENOG4107GRR phosphate transport regulator CFK37_11935 ENOG4105CJ3 phosphate transporter CFK37_11950 ENOG4105CHU acetyl-coa acetyltransferase CFK37_11955 ENOG4105C1G acyl-Coa dehydrogenase CFK37_11960 ENOG41080E8 Transcriptional regulator, Spx MgsR family CFK37_11965 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) CFK37_11980 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) CFK37_11985 ENOG4108UMI ABC transporter, permease CFK37_11990 ENOG4105D01 (LipO)protein CFK37_11995 ENOG4105C3K feS assembly ATPase SufC CFK37_12000 ENOG4105JRK feS assembly protein SufD CFK37_12005 ENOG4105C9B Cysteine desulfurase CFK37_12010 ENOG4108UNV SUF system FeS assembly protein, NifU family CFK37_12015 ENOG4105DIW FeS assembly protein SUFB CFK37_12035 ENOG4105DRS transport system, permease CFK37_12040 ENOG4105CNT hydrolase family 2 CFK37_12050 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) CFK37_12070 ENOG4107R8B 5'-nucleotidase CFK37_12075 ENOG4105KZD Domain of unknown function (DUF1805) CFK37_12080 ENOG4108YTE sporulation protein YunB CFK37_12085 ENOG4107S6Z Na H antiporter CFK37_12090 ENOG4105C8J )-transporter CFK37_12110 ENOG4105FAA peptidase M23 CFK37_12115 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) CFK37_12120 ENOG4105MMD transcriptional regulator CFK37_12195 ENOG4108ZF3 Phosphatase CFK37_12220 ENOG4108TF4 von Willebrand factor, type A CFK37_12240 ENOG4105D4U had-superfamily hydrolase, subfamily iia CFK37_12245 ENOG4108W5N phosphatidylglycerophosphatase a CFK37_12255 ENOG41083MR nifu domain-containing protein CFK37_12265 ENOG4108YX9 iron--sulfur cluster insertion protein erpA CFK37_12270 ENOG4105CAY ferredoxin--nadp reductase CFK37_12275 ENOG4105CEP NADH dehydrogenase CFK37_12285 ENOG41069ER domain protein CFK37_12300 ENOG4105D3A purine nucleoside phosphorylase DeoD-type CFK37_12305 ENOG4105KRI phosphocarrier protein (HPr CFK37_12315 ENOG4107W2M Sodium hydrogen exchanger CFK37_12330 ENOG4105C87 Aminotransferase class I and II CFK37_12335 ENOG4107QYV phosphohexose isomerase CFK37_12350 ENOG4107PBV potassium channel CFK37_12360 ENOG4105CN9 Peptidase m42 family protein CFK37_12375 ENOG4108SAX Membrane CFK37_12380 ENOG4107QTZ amino acid CFK37_12390 ENOG4105KA0 thioesterase Superfamily protein CFK37_12395 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase CFK37_12400 ENOG4105E4F Isochorismate synthase CFK37_12405 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) CFK37_12410 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) CFK37_12415 ENOG4105CEY Amp-dependent synthetase and ligase CFK37_12420 ENOG4105E0A ABC, transporter CFK37_12435 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component CFK37_12445 ENOG4105D2X ABC transporter substrate-binding protein CFK37_12450 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase CFK37_12460 ENOG4108Z0R Transferase CFK37_12470 ENOG4107QTZ amino acid CFK37_12475 ENOG4105CDA abc transporter atp-binding protein CFK37_12480 ENOG4105E5Q amino acid AbC transporter CFK37_12485 ENOG4107R0W ABC transporter CFK37_12495 ENOG4105C8T Leucyl-tRNA synthetase CFK37_12505 ENOG41085GJ domain protein CFK37_12545 ENOG4105YW5 deoR family transcriptional regulator CFK37_12550 ENOG4107F58 2'-5' rna ligase CFK37_12555 ENOG4108V15 phosphotransferase enzyme family CFK37_12565 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) CFK37_12570 ENOG4105C8F Beta-lactamase domain protein CFK37_12575 ENOG4105FDF Could be involved in DNA repair (By similarity) CFK37_12580 ENOG4105DQE DNA ligase CFK37_12595 ENOG4108K16 Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) CFK37_12600 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) CFK37_12605 ENOG4108V0E nucleoside 2-deoxyribosyltransferase YtoQ CFK37_12615 ENOG4108NKM UPF0354 protein CFK37_12620 ENOG4108VDD TRNA binding domain protein CFK37_12635 ENOG4105DFU Cell wall formation (By similarity) CFK37_12650 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase CFK37_12655 ENOG4105ETE Transcriptional regulator (LacI family CFK37_12660 ENOG4105DGU Histone deacetylase CFK37_12665 ENOG4105W87 Cbs domain CFK37_12670 ENOG4105F1V Acetoin utilization protein CFK37_12685 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) CFK37_12695 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) CFK37_12700 ENOG4105BZU Histidine kinase CFK37_12710 ENOG4105U5Y Transcriptional regulator CFK37_12715 ENOG4105DGY modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization (By similarity) CFK37_12725 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) CFK37_12735 ENOG4105EFZ amidohydrolase CFK37_12740 ENOG4108KKH Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) CFK37_12750 ENOG4105KBJ sporulation protein ytfj CFK37_12760 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) CFK37_12765 ENOG4105EPU Molybdenum cofactor synthesis domain protein CFK37_12770 ENOG4107YZX Universal stress protein CFK37_12775 ENOG4105DCF alanine dehydrogenase CFK37_12780 ENOG4105DC7 peptidase M24 CFK37_12790 ENOG41087YS Phage shock protein A CFK37_12805 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) CFK37_12810 ENOG4105E8R UPF0173 metal-dependent hydrolase CFK37_12830 ENOG4107QHF type ii secretion system protein e CFK37_12835 ENOG4105CZX twitching motility protein CFK37_12850 ENOG4106A3R peptidase CFK37_12890 ENOG4105SFS phosphoesterase RecJ domain protein CFK37_12895 ENOG4106EVM CFK37_12905 ENOG4105VV2 CFK37_12910 ENOG4105C0B DNA polymerase III (alpha subunit) CFK37_12915 ENOG4105C6K Malic enzyme CFK37_12920 ENOG41073TP transcriptional regulator CFK37_12925 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) CFK37_12930 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) CFK37_12935 ENOG4105CTQ phosphohexokinase CFK37_12940 ENOG4105CA9 Pyruvate kinase CFK37_12945 ENOG4105FS0 cytoplasmic membrane protein CFK37_12950 ENOG4108REF Sporulation integral membrane protein ytvi CFK37_12955 ENOG4105BZN citrate synthase CFK37_12960 ENOG4108HMX isocitrate dehydrogenase (NADP) CFK37_12965 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) CFK37_12975 ENOG4105DPZ Two component transcriptional regulator (Winged helix family CFK37_12980 ENOG4105BZU Histidine kinase CFK37_12985 ENOG4105C2M dna polymerase I CFK37_12990 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) CFK37_13000 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase CFK37_13005 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) CFK37_13015 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) CFK37_13035 ENOG4105C22 threonyL-tRNA synthetase CFK37_13040 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) CFK37_13045 ENOG4105VJV 50s ribosomal protein L35 CFK37_13050 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) CFK37_13075 ENOG4105CN9 Peptidase m42 family protein CFK37_13080 ENOG4105CJ1 ABC, transporter CFK37_13100 ENOG41067MF small acid-soluble spore protein CFK37_13105 ENOG4108RWN rrna methyltransferase CFK37_13110 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) CFK37_13115 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) CFK37_13120 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) CFK37_13125 ENOG410687F Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) CFK37_13135 ENOG4105DCG PHP domain protein CFK37_13140 ENOG4105C98 muts2 protein CFK37_13150 ENOG4105CEY Amp-dependent synthetase and ligase CFK37_13155 ENOG4107Z3H Transcriptional regulator, TetR family CFK37_13160 ENOG41060WC Enoyl-CoA hydratase CFK37_13165 ENOG4105BZJ Electron transfer flavoprotein CFK37_13170 ENOG4105C10 Electron transfer flavoprotein CFK37_13175 ENOG4105K63 Thioredoxin CFK37_13180 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) CFK37_13190 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit CFK37_13200 ENOG4105E33 succinate dehydrogenase CFK37_13210 ENOG4105PFC Transcriptional regulator CFK37_13215 ENOG41067TZ transcriptional regulator, MarR family CFK37_13220 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) CFK37_13225 ENOG4108XJQ germination protein CFK37_13230 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) CFK37_13235 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) CFK37_13240 ENOG4105M59 Phosphodiesterase, mj0936 family CFK37_13260 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation CFK37_13265 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) CFK37_13275 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) CFK37_13280 ENOG4105CT1 (ABC) transporter CFK37_13285 ENOG4105E5Q amino acid AbC transporter CFK37_13290 ENOG4105CDA abc transporter atp-binding protein CFK37_13300 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) CFK37_13310 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) CFK37_13320 ENOG4105D52 delta-aminolevulinic acid dehydratase CFK37_13325 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase CFK37_13330 ENOG41068KH stage VI sporulation protein D CFK37_13330 ENOG41068KH stage VI sporulation protein D CFK37_13345 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) CFK37_13355 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) CFK37_13360 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase CFK37_13370 ENOG4105W5Q DNA repair protein (RadC CFK37_13375 ENOG4105DFF Rod shape-determining protein mreb CFK37_13380 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) CFK37_13390 ENOG4107YDG Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) CFK37_13395 ENOG4107QMS site-determining protein CFK37_13410 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) CFK37_13415 ENOG4105X36 (ribosomal) protein CFK37_13420 ENOG4105K46 50S ribosomal protein l27 CFK37_13440 ENOG4107RA1 nh(3)-dependent nad( ) synthetase CFK37_13450 ENOG4105CDY transcriptional regulatory protein CFK37_13455 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) CFK37_13460 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) CFK37_13470 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) CFK37_13475 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) CFK37_13480 ENOG4105VIE preprotein translocase, subunit YajC CFK37_13485 ENOG4105NAP CFK37_13490 ENOG4105CKP Polysaccharide Biosynthesis Protein CFK37_13500 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) CFK37_13505 ENOG41067VP Protein of unknown function (DUF1049) CFK37_13510 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) CFK37_13515 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) CFK37_13520 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) CFK37_13525 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) CFK37_13530 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase CFK37_13535 ENOG4105CUT histidyl-tRNA synthetase CFK37_13540 ENOG4105C9M aspartyl-trna synthetase CFK37_13550 ENOG4108VCI transcription factor, rsfa family CFK37_13555 ENOG4105D1H recombination factor protein RarA CFK37_13565 ENOG4105C3J Cysteine desulfurase CFK37_13570 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) CFK37_13580 ENOG4105C7H Helicase, RecD TraA family CFK37_13585 ENOG41060CR CFK37_13590 ENOG4105C02 permease CFK37_13595 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) CFK37_13600 ENOG4105VBH UPF0297 protein CFK37_13605 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) CFK37_13615 ENOG4105HHA aminodeoxychorismate lyase CFK37_13620 ENOG4108VQJ O-methyltransferase CFK37_13625 ENOG4105DBI uridine monophosphokinase CFK37_13630 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) CFK37_13640 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) CFK37_13645 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CFK37_13650 ENOG4105KJM monovalent cation h antiporter subunit g CFK37_13660 ENOG4105SC1 monovalent cation H antiporter subunit E CFK37_13665 ENOG4108JPZ Monovalent cation H antiporter subunit D CFK37_13670 ENOG4108ZE9 Monovalent cation H antiporter subunit C CFK37_13675 ENOG4105D65 subunit l CFK37_13685 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase CFK37_13690 ENOG4105CQW ribosome biogenesis GTPase YqeH CFK37_13695 ENOG4105E2X shikimate dehydrogenase CFK37_13700 ENOG410812S Rna-binding protein CFK37_13705 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) CFK37_13710 ENOG4108WF2 Metal Dependent Phosphohydrolase CFK37_13720 ENOG4105DXX methyltransferase CFK37_13725 ENOG4105KQC Competence protein CFK37_13730 ENOG4108UK2 deaminase CFK37_13735 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 CFK37_13745 ENOG4105TQK DNA polymerase iii, delta' subunit CFK37_13750 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) CFK37_13755 ENOG4105CEF Initiates the rapid degradation of small, acid-soluble proteins during spore germination (By similarity) CFK37_13760 ENOG4108ZRV stage ii sporulation protein p CFK37_13770 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) CFK37_13775 ENOG4105CSA Coproporphyrinogen iii oxidase CFK37_13780 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) CFK37_13785 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ CFK37_13790 ENOG4105CFG Acts as a chaperone (By similarity) CFK37_13795 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) CFK37_13800 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) CFK37_13805 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) CFK37_13810 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) CFK37_13815 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) CFK37_13820 ENOG4105VCC 30S ribosomal protein S21 CFK37_13825 ENOG4105KTH gatB Yqey CFK37_13830 ENOG4105F7J membrane-bound serine protease CFK37_13835 ENOG4105DI5 UPF0365 protein CFK37_13845 ENOG41068P3 sporulation protein YqfC CFK37_13855 ENOG4105C9A Phoh family CFK37_13860 ENOG4105CTJ Metal Dependent Phosphohydrolase CFK37_13865 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) CFK37_13875 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) CFK37_13885 ENOG4108SAY Involved in DNA repair and RecF pathway recombination (By similarity) CFK37_13890 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit CFK37_13895 ENOG4105C38 Glycyl-tRNA synthetase beta subunit CFK37_13905 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) CFK37_13910 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) CFK37_13915 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CFK37_13930 ENOG4105EGD dinuclear metal center protein, YbgI family CFK37_13940 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) CFK37_13950 ENOG41069ZM Protein of unknown function (DUF2624) CFK37_13955 ENOG41063Y9 CFK37_13970 ENOG4108UTW Plays a role in the regulation of phosphate uptake CFK37_14015 ENOG4107RF6 penicillin-binding protein CFK37_14020 ENOG4105EXS phosphate abc transporter CFK37_14025 ENOG4105C8U phosphate abc transporter CFK37_14030 ENOG4105E2Z phosphate ABC transporter (Permease CFK37_14035 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) CFK37_14040 ENOG4108UTW Plays a role in the regulation of phosphate uptake CFK37_14055 ENOG4105WDJ 50S ribosomal protein L33 CFK37_14060 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase CFK37_14065 ENOG4105D06 uba thif-type nad fad binding protein CFK37_14075 ENOG4107ZXI Rhomboid family CFK37_14095 ENOG4105DKQ ROK family CFK37_14100 ENOG4105E0M Sulfatase CFK37_14110 ENOG4105C5X domain protein CFK37_14140 ENOG4106855 Competence protein CFK37_14170 ENOG4105C0D helicase CFK37_14175 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) CFK37_14180 ENOG4107QK8 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor CFK37_14185 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor CFK37_14190 ENOG4105WZW rhodanese family CFK37_14195 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) CFK37_14200 ENOG4105C26 Dehydrogenase CFK37_14205 ENOG4105KST dependent repressor CFK37_14225 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) CFK37_14230 ENOG4105DC7 peptidase M24 CFK37_14235 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) CFK37_14245 ENOG4105CD2 stage iii sporulation protein aa CFK37_14250 ENOG4105KR5 Stage iii sporulation protein CFK37_14255 ENOG4108CQH stage III sporulation protein AC CFK37_14260 ENOG4105KQ4 Stage iii sporulation protein ad CFK37_14270 ENOG410644B Stage III sporulation protein af CFK37_14300 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase CFK37_14305 ENOG4108ZSR alkaline shock protein CFK37_14310 ENOG4105M7K Involved in the transcription termination process (By similarity) CFK37_14315 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) CFK37_14320 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) CFK37_14325 ENOG41084DP Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) CFK37_14340 ENOG4105DX0 Hemolysin A CFK37_14345 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) CFK37_14350 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) CFK37_14355 ENOG4105S1Z Stage IV sporulation protein B CFK37_14365 ENOG4107QQR Sporulation CFK37_14370 ENOG4106CCJ Protein of unknown function (DUF2627) CFK37_14375 ENOG4108JUB Transcriptional regulator CFK37_14385 ENOG4107RDP Dehydrogenase CFK37_14405 ENOG4105CPP Dehydrogenase, E1 component CFK37_14410 ENOG4105C7S Dehydrogenase CFK37_14415 ENOG4108Y6J UPF0403 protein CFK37_14420 ENOG4108QEG Membrane CFK37_14435 ENOG4108HNZ carboxyl transferase CFK37_14440 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) CFK37_14445 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) CFK37_14450 ENOG4105CHR reductase CFK37_14455 ENOG4105CEY Amp-dependent synthetase and ligase CFK37_14460 ENOG4108J59 Extracellular solute-binding protein, family 5 CFK37_14465 ENOG4105C26 Dehydrogenase CFK37_14470 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) CFK37_14475 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase CFK37_14480 ENOG4108QXE glycerophosphoryl diester phosphodiesterase CFK37_14490 ENOG41069FQ Metallo-beta-lactamase superfamily CFK37_14495 ENOG4108IXY short-chain dehydrogenase reductase CFK37_14505 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) CFK37_14510 ENOG4105CPC Aldo Keto reductase CFK37_14525 ENOG4105MZ9 stage II sporulation protein m CFK37_14530 ENOG4105I3K Ferric uptake regulator, Fur family CFK37_14540 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) CFK37_14545 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) CFK37_14560 ENOG4105DZ1 carboxypeptidase CFK37_14565 ENOG41082AN stage II sporulation protein CFK37_14570 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) CFK37_14575 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CFK37_14595 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) CFK37_14600 ENOG4107ZE5 PPIases accelerate the folding of proteins CFK37_14615 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) CFK37_14620 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) CFK37_14625 ENOG4105DZ1 carboxypeptidase CFK37_14630 ENOG4108JIC nucleoside recognition domain protein CFK37_14640 ENOG4105FE9 pseudouridine synthase CFK37_14645 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen CFK37_14650 ENOG4107TWT Cytochrome c biogenesis protein CFK37_14655 ENOG4105CRE cytochrome C CFK37_14660 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CFK37_14665 ENOG4105BZU Histidine kinase CFK37_14690 ENOG4105C9U ATP-dependent DNA helicase RecQ CFK37_14695 ENOG4105I7S Abortive infection protein CFK37_14705 ENOG4105WEF catalase CFK37_14720 ENOG4107RGJ metallophosphoesterase CFK37_14725 ENOG4108S6Z Negative regulator of genetic competence CFK37_14735 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase CFK37_14740 ENOG4105HDK L-asparaginase CFK37_14745 ENOG4108PNU Involved in the degradation of specific anti-sigma factors (By similarity) CFK37_14750 ENOG4105F0V Cell wall hydrolase CFK37_14755 ENOG4105MSI germination protein ypeb CFK37_14760 ENOG4105CAT Cytidine monophosphate kinase CFK37_14765 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) CFK37_14775 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) CFK37_14780 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase CFK37_14800 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) CFK37_14805 ENOG4105K70 DNA-binding protein CFK37_14810 ENOG4105WP2 Tryptophan RNA-binding attenuator protein CFK37_14815 ENOG4105XXQ heptaprenyl diphosphate synthase component I CFK37_14820 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) CFK37_14825 ENOG4105EAH synthase CFK37_14830 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) CFK37_14835 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase CFK37_14840 ENOG4105D49 3-dehydroquinate synthase CFK37_14845 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase CFK37_14850 ENOG41068YB TPR repeat-containing protein CFK37_14855 ENOG4108SXZ UPF0302 protein CFK37_14865 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) CFK37_14870 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) CFK37_14875 ENOG4105PE6 Menaquinol-cytochrome c reductase, cytochrome b c subunit CFK37_14895 ENOG4108JYZ YitT family CFK37_14900 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase CFK37_14905 ENOG4108Z5K methylglyoxal synthase CFK37_14910 ENOG4105CPK Glycosyl transferase (Group 1 CFK37_14915 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate CFK37_14935 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) CFK37_14940 ENOG4105DVT helicase CFK37_14945 ENOG4105YAC CFK37_14955 ENOG4105CHM Aminotransferase CFK37_14960 ENOG4105C5S asparaginyl-tRNA synthetase CFK37_14970 ENOG4105CSM endonuclease III CFK37_14975 ENOG4105BZ4 penicillin-binding protein CFK37_14980 ENOG4108UI2 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) CFK37_15000 ENOG4105KG3 cytidine deaminase CFK37_15005 ENOG4105XWG Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation (By similarity) CFK37_15015 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) CFK37_15020 ENOG4105CTD carboxy-peptidase CFK37_15025 ENOG41065KQ synthase CFK37_15060 ENOG4105ME7 Membrane CFK37_15065 ENOG41069ER domain protein CFK37_15080 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) CFK37_15085 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) CFK37_15090 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) CFK37_15095 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) CFK37_15100 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) CFK37_15105 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) CFK37_15115 ENOG4107RFY SbcCD D subunit CFK37_15120 ENOG4105EYH Exonuclease CFK37_15130 ENOG4105E0X reductase CFK37_15140 ENOG410902C phosphohistidine phosphatase, SixA CFK37_15155 ENOG410855V Acylphosphatase CFK37_15160 ENOG4105KXX peptidase s58 dmpa CFK37_15165 ENOG41069ER domain protein CFK37_15175 ENOG4105BZN citrate synthase CFK37_15180 ENOG4105BZN citrate synthase CFK37_15190 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) CFK37_15195 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) CFK37_15200 ENOG4105H67 Protein of unknown function (DUF421) CFK37_15220 ENOG4105C4B ABC transporter, permease CFK37_15245 ENOG410890F Dynamin family CFK37_15250 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) CFK37_15255 ENOG4105MXW flavin reductase domain protein, FMN-binding CFK37_15260 ENOG4107QX3 carboxylase CFK37_15265 ENOG4105E39 Enoyl-CoA hydratase CFK37_15270 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase CFK37_15275 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit CFK37_15280 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase CFK37_15285 ENOG4105CEY Amp-dependent synthetase and ligase CFK37_15290 ENOG4105C1G acyl-Coa dehydrogenase CFK37_15305 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) CFK37_15310 ENOG4105K4P CoA-binding domain protein CFK37_15320 ENOG4108IJ8 ABC transporter CFK37_15325 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) CFK37_15330 ENOG4105DZA Converts GTP to 7,8-dihydroneopterin triphosphate (By similarity) CFK37_15335 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) CFK37_15355 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen CFK37_15360 ENOG4108I0Z Aconitate hydratase CFK37_15365 ENOG4105BZU Histidine kinase CFK37_15380 ENOG4105HC0 Na H antiporter CFK37_15385 ENOG4107QIV Cytochrome c biogenesis protein CFK37_15390 ENOG4105VXM UPF0154 protein CFK37_15405 ENOG4105VPS UPF0291 protein CFK37_15410 ENOG4108SVB resolvase CFK37_15415 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) CFK37_15420 ENOG4105C5F glutamine synthetase CFK37_15425 ENOG4105KV4 Transcriptional regulator CFK37_15430 ENOG4105EKQ RNA-directed DNA polymerase CFK37_15435 ENOG4105CXI aluminum resistance protein CFK37_15440 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) CFK37_15445 ENOG4106F1P AAA ATPase, central domain protein CFK37_15450 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) CFK37_15455 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) CFK37_15460 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) CFK37_15465 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) CFK37_15480 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) CFK37_15485 ENOG4105MCT stage V sporulation protein S CFK37_15490 ENOG4105D48 metallophosphoesterase CFK37_15495 ENOG4105E4Y Endoribonuclease that initiates mRNA decay (By similarity) CFK37_15500 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) CFK37_15505 ENOG4105CEV competence damage-inducible protein CFK37_15510 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase CFK37_15525 ENOG4105XZV Protein of unknown function (DUF3243) CFK37_15530 ENOG4108RKS Short-chain dehydrogenase reductase Sdr CFK37_15550 ENOG4105UIB (ABC) transporter CFK37_15555 ENOG4108JQ9 ABC transporter CFK37_15560 ENOG4105DIH basic membrane CFK37_15565 ENOG4105FDP GntR family transcriptional regulator CFK37_15570 ENOG4105CNU cell division protein FtsK CFK37_15580 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit CFK37_15585 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) CFK37_15595 ENOG4108S0H Dipicolinic acid synthetase, b subunit CFK37_15600 ENOG4105E35 Dipicolinate synthase subunit A CFK37_15610 ENOG4105C1V Peptidase, M16 CFK37_15620 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) CFK37_15625 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) CFK37_15630 ENOG4105DTN riboflavin biosynthesis protein ribF CFK37_15635 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) CFK37_15640 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) CFK37_15650 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) CFK37_15660 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination CFK37_15665 ENOG4105CHV Transcription elongation factor NusA CFK37_15670 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) CFK37_15675 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) CFK37_15680 ENOG4105DZP Membrane-associated zinc metalloprotease CFK37_15685 ENOG4105KNE Phosphatidate cytidylyltransferase CFK37_15690 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) CFK37_15695 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) CFK37_15700 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) CFK37_15705 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) CFK37_15710 ENOG4105CE9 30S ribosomal protein S2 CFK37_15715 ENOG4105EUM DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor (By similarity) CFK37_15720 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) CFK37_15725 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) CFK37_15730 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) CFK37_15740 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) CFK37_15745 ENOG4105C79 DNA protecting protein DprA CFK37_15750 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha CFK37_15755 ENOG4105CMV Succinyl-CoA synthetase subunit beta CFK37_15760 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) CFK37_15765 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) CFK37_15775 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) CFK37_15780 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) CFK37_15795 ENOG4105VB6 UPF0109 protein CFK37_15800 ENOG4105K5M 30s ribosomal protein S16 CFK37_15810 ENOG4105VBN Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) CFK37_15815 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) CFK37_15820 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) CFK37_15825 ENOG4108CPA Protein of unknown function (DUF1128) CFK37_15830 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) CFK37_15835 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) CFK37_15840 ENOG4105CHR reductase CFK37_15845 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase CFK37_15850 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) CFK37_15855 ENOG4108VVV Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism (By similarity) CFK37_15860 ENOG4105CB5 ATP-dependent DNA helicase recG CFK37_15865 ENOG4105EJQ L-serine dehydratase CFK37_15885 ENOG4105VFR signal peptidase CFK37_15890 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin CFK37_15915 ENOG4108S4H thioesterase Superfamily protein CFK37_15920 ENOG4108QY0 Membrane CFK37_15930 ENOG4105DP4 dak2 domain fusion protein ylov CFK37_15935 ENOG4108ZAA Alkaline-shock protein CFK37_15940 ENOG4105VB9 50S ribosomal protein l28 CFK37_15950 ENOG4105FJ0 thiamine CFK37_15955 ENOG4105DJV ribulose-phosphate 3-epimerase CFK37_15960 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) CFK37_15965 ENOG4105D9P serine threonine protein kinase CFK37_15970 ENOG4108ZF3 Phosphatase CFK37_15975 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B CFK37_15980 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) CFK37_15985 ENOG4105C25 Primosomal protein n' CFK37_15990 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase CFK37_15995 ENOG4105ZAD Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) CFK37_16000 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) CFK37_16005 ENOG4105KC4 UPF0296 protein CFK37_16015 ENOG4105F23 Fibronectin-binding protein CFK37_16020 ENOG4108ZHJ Organic hydroperoxide resistance protein CFK37_16025 ENOG4108WAV Transcriptional regulator CFK37_16030 ENOG41089UC methyltransferase, type 11 CFK37_16035 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) CFK37_16040 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) CFK37_16045 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) CFK37_16050 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) CFK37_16055 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain CFK37_16060 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain CFK37_16065 ENOG4105CD3 dihydroorotase CFK37_16070 ENOG4105CXT aspartate transcarbamylase CFK37_16075 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) CFK37_16080 ENOG4105C34 Pseudouridine synthase CFK37_16085 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) CFK37_16090 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) CFK37_16105 ENOG41067XK integral membrane protein CFK37_16110 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) CFK37_16115 ENOG4105DFA alanine racemase domain protein CFK37_16120 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase CFK37_16125 ENOG4105WR5 sporulation protein, YlmC YmxH family CFK37_16135 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CFK37_16140 ENOG4108AWX Sporulation factor SpoIIGA CFK37_16145 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) CFK37_16150 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) CFK37_16155 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) CFK37_16160 ENOG4105CNI cell division protein FtsW CFK37_16165 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) CFK37_16170 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) CFK37_16175 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) CFK37_16180 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) CFK37_16185 ENOG4105CJN penicillin-binding protein CFK37_16190 ENOG4105CJN penicillin-binding protein CFK37_16200 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) CFK37_16205 ENOG4108V6E Cell division protein mraZ CFK37_16210 ENOG41074B2 UPF0747 protein CFK37_16225 ENOG4108YG3 N-acetyltransferase CFK37_16230 ENOG4108VCI transcription factor, rsfa family CFK37_16235 ENOG4105E39 Enoyl-CoA hydratase CFK37_16240 ENOG41067VY 50S ribosomal protein L32 CFK37_16245 ENOG4105KNH Nucleic acid-binding protein CFK37_16250 ENOG4105CDE UPF0348 protein CFK37_16255 ENOG41063PX domain protein CFK37_16260 ENOG4105H20 Sporulation integral membrane protein YlbJ CFK37_16265 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) CFK37_16270 ENOG4106H78 methyltransferase CFK37_16275 ENOG4105WUC UPF0298 protein CFK37_16295 ENOG4106UY4 Inherit from COG: Scp-like extracellular CFK37_16340 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) CFK37_16345 ENOG4107SGF Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity) CFK37_16350 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) CFK37_16355 ENOG4105CNI cell division protein FtsW CFK37_16360 ENOG4105ZPI UPF0358 protein CFK37_16385 ENOG4105QA2 CFK37_16395 ENOG4105ECY inositol monophosphatase CFK37_16405 ENOG4108WQ8 UPF0637 protein CFK37_16410 ENOG4105WBI UPF0223 protein CFK37_16415 ENOG4105EA8 2-Nitropropane dioxygenase CFK37_16420 ENOG4105CXN decarboxylase CFK37_16430 ENOG4108ZJ4 polysaccharide deacetylase CFK37_16435 ENOG4105C94 Transporter CFK37_16445 ENOG4105C7S Dehydrogenase CFK37_16450 ENOG4105CPP Dehydrogenase, E1 component CFK37_16465 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) CFK37_16470 ENOG4106148 UPF0356 protein CFK37_16475 ENOG4105CN5 Metallo-Beta-Lactamase CFK37_16490 ENOG4107ZYR domain protein CFK37_16495 ENOG4105BZ1 (ABC) transporter CFK37_16500 ENOG4105BZ1 (ABC) transporter CFK37_16505 ENOG4107R19 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen CFK37_16510 ENOG4105D3R alkyl hydroperoxide reductase CFK37_16515 ENOG4105D8X mechanosensitive ion channel CFK37_16535 ENOG4108UT2 hemolysin iii CFK37_16540 ENOG4105K6S Short-chain dehydrogenase reductase Sdr CFK37_16550 ENOG4108KF3 Electron transport protein SCO1 SenC CFK37_16555 ENOG4105UIN CFK37_16585 ENOG4105C0H protease CFK37_16590 ENOG4105BZU Histidine kinase CFK37_16600 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR CFK37_16615 ENOG4105CK7 Sodium proline symporter CFK37_16630 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) CFK37_16635 ENOG4105CVM Molybdenum cofactor synthesis domain protein CFK37_16660 ENOG41090VF Stage v sporulation protein ac CFK37_16665 ENOG4105CZ3 stage V sporulation protein ad CFK37_16680 ENOG4108QY0 Membrane CFK37_16700 ENOG4108QY0 Membrane CFK37_16705 ENOG4105CB2 alcohol dehydrogenase CFK37_16720 ENOG4105D22 carbon starvation protein CFK37_16730 ENOG4108HIZ formate dehydrogenase alpha subunit CFK37_16735 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) CFK37_16750 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) CFK37_16755 ENOG4105CEY Amp-dependent synthetase and ligase CFK37_16760 ENOG4105N67 Proton-coupled thiamine transporter YuaJ CFK37_16770 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase CFK37_16780 ENOG4108YYC ycei family CFK37_16785 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) CFK37_16790 ENOG4105S6R Iron-hydroxamate transporter permease subunit CFK37_16795 ENOG4105J76 Periplasmic binding protein CFK37_16805 ENOG4105CEP NADH dehydrogenase CFK37_16820 ENOG4105CEY Amp-dependent synthetase and ligase CFK37_16830 ENOG4105C7Z Conserved Protein CFK37_16835 ENOG4105C9U ATP-dependent DNA helicase RecQ CFK37_16840 ENOG4105DIN metallophosphoesterase CFK37_16850 ENOG4105BZ1 (ABC) transporter CFK37_16870 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) CFK37_16875 ENOG4105CAQ asparagine synthetase CFK37_16885 ENOG4105BZ1 (ABC) transporter CFK37_16890 ENOG4105K64 Glycosyl transferase, family 2 CFK37_16905 ENOG4105CGN Glycosyl transferase (Group 1 CFK37_16930 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase CFK37_16935 ENOG4105MME Sugar o-acyltransferase, sialic acid o-acetyltransferase neud family CFK37_16940 ENOG4105D3Q Sugar transferase CFK37_16945 ENOG4105CMR udp-glucose 4-epimerase CFK37_16950 ENOG41068W6 Capsular polysaccharide biosynthesis protein CFK37_16955 ENOG4105K64 Glycosyl transferase, family 2 CFK37_16960 ENOG4108KMV Glycosyl transferase (Group 1 CFK37_16965 ENOG4108PQP glycosyl transferase group 1 CFK37_16970 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase CFK37_16980 ENOG4107YJ4 chain length determinant protein CFK37_17010 ENOG4105CQC Prephenate dehydratase CFK37_17020 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) CFK37_17040 ENOG4107RVU D-Ala-D-Ala carboxypeptidase 3 (S13) family CFK37_17045 ENOG41080V3 Major Facilitator superfamily CFK37_17095 ENOG4105C7B Threonine dehydratase CFK37_17100 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) CFK37_17105 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) CFK37_17110 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) CFK37_17115 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) CFK37_17120 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase CFK37_17125 ENOG4108ZP8 Acetolactate synthase small subunit CFK37_17130 ENOG4105C7K acetolactate synthase CFK37_17135 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) CFK37_17140 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) CFK37_17145 ENOG4105D6E homoserine dehydrogenase CFK37_17160 ENOG4105C01 Dihydroxy-acid dehydratase CFK37_17170 ENOG4108JQ1 Dehydrogenase CFK37_17175 ENOG4105U0R haloacid dehalogenase-like hydrolase CFK37_17180 ENOG4105CM2 brancheD-chain amino acid aminotransferase CFK37_17195 ENOG4105MYT Heat shock protein CFK37_17215 ENOG41067MG lrgb family CFK37_17220 ENOG4105VAW lrga family CFK37_17225 ENOG4105CMU LysR family (Transcriptional regulator CFK37_17235 ENOG4105DFD Na H antiporter CFK37_17240 ENOG4105DTQ mandelate racemase muconate lactonizing CFK37_17295 ENOG4105K6H D-cysteine desulfhydrase CFK37_17310 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) CFK37_17325 ENOG4105C09 Bile acid CFK37_17335 ENOG4105CIH Imidazole acetol-phosphate transaminase CFK37_17340 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase CFK37_17345 ENOG4105CHM Aminotransferase CFK37_17350 ENOG4105CFH Aspartokinase CFK37_17355 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) CFK37_17360 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) CFK37_17365 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) CFK37_17375 ENOG4105CH2 amidohydrolase CFK37_17380 ENOG4108XFP Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) CFK37_17405 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) CFK37_17410 ENOG4105DGI Alkaline phosphatase CFK37_17425 ENOG4105C22 threonyL-tRNA synthetase CFK37_17450 ENOG4105C37 (CBS) domain CFK37_17470 ENOG4105DMQ Methyltransferase CFK37_17485 ENOG4107R5R arsenical pump membrane protein CFK37_17490 ENOG41082YX Transcriptional regulator, arsr family CFK37_17495 ENOG4105BZ8 glutamate synthase CFK37_17500 ENOG4105CBC glutamate synthase CFK37_17505 ENOG4105C5Q Transcriptional regulator CFK37_17515 ENOG4108UZX fmn reductase CFK37_17520 ENOG4108Z6K Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant (By similarity) CFK37_17535 ENOG4105ENY Ethanolamine utilization protein eutH CFK37_17540 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) CFK37_17545 ENOG4105C2W permease CFK37_17550 ENOG4105E2S oxidase) subunit II CFK37_17555 ENOG4105BZ9 Cytochrome C oxidase, subunit I CFK37_17560 ENOG4105CCU oxidase (Subunit III) CFK37_17580 ENOG4107R8B 5'-nucleotidase CFK37_17620 ENOG4107SJ1 Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity) CFK37_17625 ENOG4107R6D beta-lactam binding protein AmpH CFK37_17630 ENOG4105J76 Periplasmic binding protein CFK37_17640 ENOG41068WN CFK37_17660 ENOG4105D7K pfkb domain protein CFK37_17675 ENOG41080HJ 6-phospho 3-hexuloisomerase CFK37_17690 ENOG4105C0R drug resistance transporter emrb qaca subfamily CFK37_17695 ENOG4105C85 amino acid CFK37_17705 ENOG4105C0D helicase CFK37_17725 ENOG41075D4 Aminoglycoside 6-adenylyltransferase CFK37_17740 ENOG4105EHZ conserved protein UCP016719 CFK37_17745 ENOG4105VCP PTS System CFK37_17750 ENOG410901P UPF0249 protein CFK37_17755 ENOG4105CK1 PTS System CFK37_17765 ENOG4105F8D glycoside hydrolase family 4 CFK37_17770 ENOG4105EMD TRANSCRIPTIONal CFK37_17780 ENOG4107YZX Universal stress protein CFK37_17785 ENOG4105C0R drug resistance transporter emrb qaca subfamily CFK37_17845 ENOG4105E5H Transposase CFK37_17860 ENOG4107UX3 phosphatidylethanolamine N-methyltransferase CFK37_17915 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) CFK37_17920 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) CFK37_17925 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) CFK37_17935 ENOG4108428 Inherit from COG: -acetyltransferase CFK37_17980 ENOG4105CJ1 ABC, transporter CFK37_18000 ENOG4105D06 uba thif-type nad fad binding protein CFK37_18005 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) CFK37_18015 ENOG41080HI glycine oxidase CFK37_18020 ENOG4108VEU Thiamine monophosphate synthase CFK37_18030 ENOG4105D4Y metalloprotease CFK37_18040 ENOG4105VFR signal peptidase CFK37_18050 ENOG4108VK3 Cupin 2 Conserved Barrel Domain Protein CFK37_18055 ENOG4105CBT Fructose-1,6-bisphosphatase CFK37_18060 ENOG4108YZG isomerase CFK37_18070 ENOG4105CMT Dihydroxyacetone kinase CFK37_18075 ENOG4105IE8 Alpha-ketoglutarate permease CFK37_18080 ENOG4105CPQ Dehydrogenase CFK37_18085 ENOG4105E98 transcriptional regulator DeoR family CFK37_18125 ENOG4105D4T Citrate transporter CFK37_18130 ENOG4108JUB Transcriptional regulator CFK37_18135 ENOG4108VP3 Lysine exporter protein (LysE YggA) CFK37_18140 ENOG4107V2S Transcriptional regulator CFK37_18145 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes CFK37_18160 ENOG4107V0Z fmn reductase CFK37_18205 ENOG4108MK9 spermidine N(1)-acetyltransferase CFK37_18210 ENOG4105D3W isochorismatase CFK37_18215 ENOG4105NAE bifunctional deaminase-reductase domain protein CFK37_18270 ENOG4108W0I acetyltransferase CFK37_18280 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) CFK37_18290 ENOG4108NHD germination protein CFK37_18320 ENOG41067SE Tetr family transcriptional regulator CFK37_18325 ENOG4105CZ9 Domain of unknown function (DU1801) CFK37_18345 ENOG4105NX3 Membrane CFK37_18350 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) CFK37_18355 ENOG4105VMP Transcriptional regulator CFK37_18380 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 CFK37_18395 ENOG4105KIR Thiol-disulfide oxidoreductase dcc CFK37_18410 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A CFK37_18415 ENOG4105DZ6 Band 7 protein CFK37_18430 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein CFK37_18435 ENOG4105D17 glycoside hydrolase, family 3 domain protein CFK37_18450 ENOG4105KR8 Inherit from COG: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) CFK37_18480 ENOG4108IJ7 Glycine betaine CFK37_18485 ENOG4108HQS Glycine betaine CFK37_18510 ENOG4105VZ8 Transcriptional regulator CFK37_18530 ENOG41061TZ Short-chain dehydrogenase reductase Sdr CFK37_18535 ENOG4105EWI Short-chain dehydrogenase reductase Sdr CFK37_18580 ENOG4108Z86 Glutamine amidotransferase CFK37_18585 ENOG4105CN2 monooxygenase, FAD-binding CFK37_18615 ENOG4105RHY Pfam:UPF0157 CFK37_18620 ENOG4108YYS metal-dependent hydrolase (By similarity) CFK37_18635 ENOG4105VRR gCN5-related N-acetyltransferase CFK37_18660 ENOG4105BZU Histidine kinase CFK37_18665 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CFK37_18670 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen CFK37_18675 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen CFK37_18680 ENOG4107QIV Cytochrome c biogenesis protein CFK37_18690 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) CFK37_18710 ENOG4108RE9 Phosphodiesterase CFK37_18715 ENOG4105F99 Hydroxymethylglutaryl-CoA synthase CFK37_18725 ENOG4105GMT ATPase associated with various cellular activities aaa_5 CFK37_18730 ENOG4107T89 von Willebrand factor, type A CFK37_18755 ENOG4108ZYE Transcriptional regulator CFK37_18765 ENOG4105C59 p-type ATPase CFK37_18800 ENOG4105DY8 decarboxylase CFK37_18815 ENOG4107ZE5 PPIases accelerate the folding of proteins CFK37_18825 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase CFK37_18855 ENOG4105KCT ABC transporter CFK37_18860 ENOG4108M15 ABC transporter CFK37_18880 ENOG4105CK2 sodium dicarboxylate symporter CFK37_18885 ENOG4105BZW Glycerate kinase CFK37_18890 ENOG4105VRS hydrolase family 18 CFK37_18915 ENOG4108MK9 spermidine N(1)-acetyltransferase CFK37_18950 ENOG4105JVQ RNA Polymerase CFK37_18970 ENOG4108F19 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) CFK37_19010 ENOG4105GIG CFK37_19025 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A CFK37_19030 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) CFK37_19050 ENOG4105EMN RNA polymerase sigma factor CFK37_19070 ENOG4105RHY Pfam:UPF0157 CFK37_19080 ENOG4108V4B ThiJ pfpI CFK37_19115 ENOG4107RGD Major Facilitator superfamily CFK37_19120 ENOG4105CAQ asparagine synthetase CFK37_19135 ENOG4105C28 cystathionine CFK37_19145 ENOG4105F6J Alpha beta hydrolase fold CFK37_19155 ENOG4105C19 ABC transporter CFK37_19165 ENOG4105BZU Histidine kinase CFK37_19200 ENOG4108IPT Naphthoate synthase CFK37_19220 ENOG41085FC arsR family transcriptional regulator CFK37_19240 ENOG4108UXE Protein tyrosine phosphatase CFK37_19245 ENOG4107R5R arsenical pump membrane protein CFK37_19250 ENOG41082YX Transcriptional regulator, arsr family CFK37_19265 ENOG4105JQZ Methyltransferase CFK37_19270 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) CFK37_19275 ENOG4108SJC Membrane CFK37_19280 ENOG4105JQZ Methyltransferase CFK37_19305 ENOG4105CK5 oxidoreductase CFK37_19310 ENOG4108I5G Major Facilitator superfamily CFK37_19400 ENOG4105DFD Na H antiporter CFK37_19460 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A CFK37_19485 ENOG4105CGD Nad-dependent epimerase dehydratase CFK37_19525 ENOG4108HVR ABC transporter, permease CFK37_19530 ENOG4105C19 ABC transporter CFK37_19535 ENOG4105EWM Histidine kinase CFK37_19540 ENOG4105CJZ response regulator CFK37_19555 ENOG4108ZHR arsR family transcriptional regulator CFK37_19560 ENOG4105C0R drug resistance transporter emrb qaca subfamily CFK37_19570 ENOG4105CPC Aldo Keto reductase CFK37_19585 ENOG4105DA5 (ABC) transporter CFK37_19590 ENOG41069JR CFK37_19610 ENOG41061TZ Short-chain dehydrogenase reductase Sdr CFK37_19620 ENOG4105DPZ Two component transcriptional regulator (Winged helix family CFK37_19660 ENOG4105CDU Replicative dna helicase CFK37_19685 ENOG4105CBC glutamate synthase CFK37_19720 ENOG4105E5H Transposase CFK37_19735 ENOG4105E5H Transposase CFK37_19760 ENOG4105C4R Atp-dependent dna helicase CFK37_19790 ENOG4107QMH DNA methylase CFK37_19800 ENOG4105C0D helicase CFK37_19820 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving CFK37_19825 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity)