locus-tag	class	description
CFK37_00015	COG0673	inositol 2-dehydrogenase activity
CFK37_00020	COG0673	inositol 2-dehydrogenase activity
CFK37_00050	COG1131	(ABC) transporter
CFK37_00060	COG2197	response regulator
CFK37_00095	COG3588	fructose-bisphosphate aldolase
CFK37_00100	COG0346	lactoylglutathione lyase activity
CFK37_00105	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CFK37_00110	COG0006	proline dipeptidase activity
CFK37_00135	COG1647	Serine aminopeptidase, S33
CFK37_00140	COG2860	membrane
CFK37_00145	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CFK37_00150	COG0753	catalase activity
CFK37_00155	COG1028	Short-chain dehydrogenase reductase Sdr
CFK37_00160	COG2514	catechol 2,3-dioxygenase activity
CFK37_00170	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CFK37_00195	COG1132	(ABC) transporter
CFK37_00200	COG1132	(ABC) transporter
CFK37_00205	COG2382	esterase
CFK37_00210	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
CFK37_00215	COG2153	protein acetylation
CFK37_00220	COG2323	membrane
CFK37_00225	COG2155	Conserved Protein
CFK37_00260	COG2814	Major facilitator Superfamily
CFK37_00270	COG1846	Transcriptional regulator
CFK37_00275	COG0346	lactoylglutathione lyase activity
CFK37_00280	COG2323	membrane
CFK37_00290	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CFK37_00330	COG0318	PFAM AMP-dependent synthetase and ligase
CFK37_00355	COG0514	ATP-dependent DNA helicase (RecQ)
CFK37_00385	COG5566	PFAM Mor transcription activator
CFK37_00390	COG1051	belongs to the nudix hydrolase family
CFK37_00400	COG1368	sulfuric ester hydrolase activity
CFK37_00410	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CFK37_00415	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CFK37_00420	COG0640	Transcriptional regulator
CFK37_00450	COG0456	acetyltransferase
CFK37_00460	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CFK37_00480	COG2239	Acts as a magnesium transporter
CFK37_00485	COG0772	Belongs to the SEDS family
CFK37_00490	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CFK37_00495	COG0564	pseudouridine synthase activity
CFK37_00500	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CFK37_00505	COG2357	RelA SpoT domain protein
CFK37_00510	COG4116	CYTH
CFK37_00515	COG2346	COG2346, Truncated hemoglobins
CFK37_00525	COG1164	Oligoendopeptidase f
CFK37_00535	COG4862	establishment of competence for transformation
CFK37_00540	COG1393	Belongs to the ArsC family
CFK37_00545	COG0456	acetyltransferase
CFK37_00555	COG0183	Belongs to the thiolase family
CFK37_00565	COG3583	domain protein
CFK37_00565	COG3584	3D domain protein
CFK37_00570	COG0180	Tryptophanyl-tRNA synthetase
CFK37_00585	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CFK37_00590	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CFK37_00595	COG1744	ABC transporter substrate-binding protein PnrA-like
CFK37_00635	COG0314	molybdopterin synthase activity
CFK37_00640	COG1763	Mo-molybdopterin cofactor biosynthetic process
CFK37_00645	COG2151	metal-sulfur cluster biosynthetic enzyme
CFK37_00650	COG1073	alpha beta
CFK37_00655	COG0561	phosphatase activity
CFK37_00670	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CFK37_00675	COG1307	EDD domain protein, DegV family
CFK37_00685	COG0492	ferredoxin-NADP+ reductase activity
CFK37_00690	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CFK37_00695	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CFK37_00700	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CFK37_00710	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CFK37_00715	COG2311	Membrane
CFK37_00720	COG3949	Membrane
CFK37_00725	COG2814	Major facilitator Superfamily
CFK37_00740	COG0402	S-adenosylhomocysteine deaminase activity
CFK37_00745	COG0277	FAD linked oxidase domain protein
CFK37_00750	COG1074	ATP-dependent DNA helicase activity
CFK37_00755	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
CFK37_00765	COG0398	Pfam SNARE associated Golgi protein
CFK37_00780	COG0318	PFAM AMP-dependent synthetase and ligase
CFK37_00785	COG0095	Lipoate-protein ligase
CFK37_00790	COG1234	tRNA 3'-trailer cleavage
CFK37_00815	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CFK37_00820	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CFK37_00825	COG2329	Antibiotic biosynthesis monooxygenase
CFK37_00835	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
CFK37_00840	COG2197	response regulator
CFK37_00845	COG4585	Histidine kinase
CFK37_00855	COG2814	Major facilitator Superfamily
CFK37_00865	COG2193	ferroxidase activity
CFK37_00870	COG1473	amidohydrolase
CFK37_00875	COG4473	ABC transporter
CFK37_00880	COG1131	(ABC) transporter
CFK37_00885	COG0537	adenosine 5'-monophosphoramidase activity
CFK37_00915	COG0517	IMP dehydrogenase activity
CFK37_00915	COG4175	Glycine betaine
CFK37_00920	COG1510	regulation of RNA biosynthetic process
CFK37_00940	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CFK37_00950	COG3481	metal-dependent phosphohydrolase, HD sub domain
CFK37_00955	COG1510	regulation of RNA biosynthetic process
CFK37_00960	COG4717	serine-type aminopeptidase activity
CFK37_00965	COG0420	3'-5' exonuclease activity
CFK37_00970	COG1668	transmembrane transport
CFK37_00975	COG4152	abc transporter atp-binding protein
CFK37_00995	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CFK37_00995	COG0723	plastoquinol--plastocyanin reductase activity
CFK37_01000	COG0028	Belongs to the TPP enzyme family
CFK37_01010	COG1024	Enoyl-CoA hydratase
CFK37_01015	COG3679	Belongs to the UPF0342 family
CFK37_01020	COG2508	Transcriptional regulator
CFK37_01025	COG3842	ATPase activity
CFK37_01035	COG0114	fumarate hydratase activity
CFK37_01045	COG2270	Major facilitator Superfamily
CFK37_01055	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CFK37_01060	COG1247	-acetyltransferase
CFK37_01070	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
CFK37_01075	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CFK37_01080	COG0024	Methionine aminopeptidase
CFK37_01090	COG1028	Short-chain dehydrogenase reductase Sdr
CFK37_01095	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CFK37_01100	COG0626	cystathionine gamma-synthase activity
CFK37_01105	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CFK37_01115	COG2226	methyltransferase
CFK37_01135	COG1191	sigma factor activity
CFK37_01150	COG1132	(ABC) transporter
CFK37_01155	COG1132	(ABC) transporter
CFK37_01185	COG0656	L-ascorbic acid biosynthetic process
CFK37_01195	COG2409	Drug exporters of the RND superfamily
CFK37_01195	COG1033	growth of symbiont in host cell
CFK37_01200	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CFK37_01205	COG0534	Mate efflux family protein
CFK37_01210	COG1012	belongs to the aldehyde dehydrogenase family
CFK37_01220	COG1012	belongs to the aldehyde dehydrogenase family
CFK37_01225	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CFK37_01235	COG2252	PERMEase
CFK37_01240	COG0508	dehydrogenase complex catalyzes the overall conversion of
CFK37_01245	COG0567	Dehydrogenase, E1 component
CFK37_01260	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CFK37_01285	COG0823	Involved in the tonB-independent uptake of proteins
CFK37_01285	COG1506	peptidase
CFK37_01285	COG4946	Tricorn protease homolog
CFK37_01295	COG2318	DinB family
CFK37_01320	COG0604	alcohol dehydrogenase
CFK37_01340	COG0697	spore germination
CFK37_01365	COG0318	PFAM AMP-dependent synthetase and ligase
CFK37_01370	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CFK37_01380	COG1404	Belongs to the peptidase S8 family
CFK37_01385	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CFK37_01390	COG2169	Transcriptional regulator
CFK37_01395	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
CFK37_01410	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CFK37_01420	COG1714	RDD family
CFK37_01430	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CFK37_01435	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CFK37_01440	COG2211	Major facilitator Superfamily
CFK37_01460	COG0673	inositol 2-dehydrogenase activity
CFK37_01480	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CFK37_01485	COG0800	Aldolase
CFK37_01490	COG1028	Short-chain dehydrogenase reductase Sdr
CFK37_01495	COG1312	Catalyzes the dehydration of D-mannonate
CFK37_01500	COG1904	glucuronate isomerase
CFK37_01510	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
CFK37_01520	COG2186	Transcriptional regulator
CFK37_01525	COG2186	Transcriptional regulator
CFK37_01530	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CFK37_01535	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CFK37_01540	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CFK37_01545	COG2132	Multicopper oxidase
CFK37_01550	COG2130	NADP-dependent
CFK37_01555	COG2814	Major facilitator Superfamily
CFK37_01560	COG4221	oxidoreductase activity
CFK37_01570	COG2124	cytochrome p450
CFK37_01600	COG0456	acetyltransferase
CFK37_01600	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
CFK37_01605	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CFK37_01635	COG1966	Carbon starvation protein
CFK37_01640	COG3279	Response regulator of the LytR AlgR family
CFK37_01645	COG3275	phosphorelay sensor kinase activity
CFK37_01660	COG0456	acetyltransferase
CFK37_01670	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CFK37_01675	COG0346	lactoylglutathione lyase activity
CFK37_01680	COG0137	argininosuccinate synthase activity
CFK37_01705	COG1131	(ABC) transporter
CFK37_01710	COG4474	Belongs to the UPF0398 family
CFK37_01720	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CFK37_01730	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CFK37_01735	COG1970	mechanosensitive ion channel activity
CFK37_01740	COG1970	mechanosensitive ion channel activity
CFK37_01765	COG1278	Cold shock
CFK37_01775	COG1227	inorganic diphosphatase activity
CFK37_01780	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CFK37_01780	COG0723	plastoquinol--plastocyanin reductase activity
CFK37_01790	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CFK37_01805	COG1063	alcohol dehydrogenase
CFK37_01810	COG2364	Membrane
CFK37_01815	COG0697	spore germination
CFK37_01915	COG0512	Glutamine amidotransferase of anthranilate synthase
CFK37_01920	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CFK37_01925	COG0735	belongs to the Fur family
CFK37_01930	COG2096	Adenosyltransferase
CFK37_01945	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CFK37_01955	COG0745	RESPONSE REGULATOR receiver
CFK37_01960	COG2205	protein histidine kinase activity
CFK37_01965	COG1136	(ABC) transporter
CFK37_01970	COG0577	efflux transmembrane transporter activity
CFK37_01975	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CFK37_01980	COG1132	(ABC) transporter
CFK37_01985	COG3557	Belongs to the UPF0374 family
CFK37_01995	COG1194	a g-specific adenine glycosylase
CFK37_02000	COG1988	membrane-bound metal-dependent
CFK37_02015	COG2137	regulation of response to DNA damage stimulus
CFK37_02020	COG1090	epimerase
CFK37_02040	COG1131	(ABC) transporter
CFK37_02055	COG0542	response to heat
CFK37_02065	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CFK37_02075	COG2056	Na+-H+ antiporter family
CFK37_02080	COG2046	Belongs to the sulfate adenylyltransferase family
CFK37_02085	COG3273	potassium ion transport
CFK37_02085	COG0471	metal ion transport
CFK37_02090	COG0529	Catalyzes the synthesis of activated sulfate
CFK37_02100	COG1086	Polysaccharide biosynthesis protein
CFK37_02125	COG3344	reverse transcriptase
CFK37_02140	COG0477	Major facilitator Superfamily
CFK37_02145	COG2217	Heavy metal translocating P-type atpase
CFK37_02150	COG1295	ribonuclease BN
CFK37_02160	COG1115	amino acid carrier protein
CFK37_02165	COG2135	peptidase activity
CFK37_02175	COG0860	N-Acetylmuramoyl-L-alanine amidase
CFK37_02180	COG1404	Belongs to the peptidase S8 family
CFK37_02210	COG0463	Glycosyl transferase, family 2
CFK37_02215	COG0463	Glycosyl transferase, family 2
CFK37_02245	COG0463	Glycosyl transferase, family 2
CFK37_02250	COG2066	Belongs to the glutaminase family
CFK37_02265	COG2340	Cysteine-rich secretory protein family
CFK37_02275	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CFK37_02285	COG1012	belongs to the aldehyde dehydrogenase family
CFK37_02295	COG1414	Transcriptional regulator
CFK37_02305	COG1012	belongs to the aldehyde dehydrogenase family
CFK37_02310	COG0028	Belongs to the TPP enzyme family
CFK37_02315	COG0436	Aminotransferase
CFK37_02320	COG1757	Na H antiporter
CFK37_02340	COG0733	neurotransmitter:sodium symporter activity
CFK37_02345	COG0446	pyridine nucleotide-disulphide oxidoreductase
CFK37_02355	COG0861	Integral membrane protein TerC family
CFK37_02375	COG0488	(ABC) transporter
CFK37_02385	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CFK37_02390	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CFK37_02390	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CFK37_02395	COG0307	riboflavin synthase, alpha
CFK37_02400	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CFK37_02400	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CFK37_02425	COG0714	Associated with various cellular activities
CFK37_02445	COG1595	DNA-templated transcription, initiation
CFK37_02450	COG1199	ATP-dependent helicase activity
CFK37_02455	COG0564	pseudouridine synthase activity
CFK37_02460	COG0166	Belongs to the GPI family
CFK37_02495	COG0346	lactoylglutathione lyase activity
CFK37_02500	COG0346	lactoylglutathione lyase activity
CFK37_02505	COG3340	Belongs to the peptidase S51 family
CFK37_02520	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CFK37_02530	COG0277	FAD linked oxidase domain protein
CFK37_02535	COG1785	Belongs to the alkaline phosphatase family
CFK37_02555	COG0109	protoheme IX farnesyltransferase activity
CFK37_02565	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CFK37_02590	COG3773	Cell wall hydrolase
CFK37_02610	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CFK37_02620	COG1597	lipid kinase activity
CFK37_02625	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CFK37_02630	COG0154	amidase activity
CFK37_02635	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CFK37_02645	COG1012	belongs to the aldehyde dehydrogenase family
CFK37_02650	COG4851	CamS sex pheromone cAM373 precursor
CFK37_02655	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CFK37_02660	COG0210	DNA helicase
CFK37_02665	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
CFK37_02670	COG4496	protein, YerC YecD
CFK37_02675	COG1470	cell adhesion involved in biofilm formation
CFK37_02680	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
CFK37_02685	COG0151	Belongs to the GarS family
CFK37_02690	COG0138	bifunctional purine biosynthesis protein purh
CFK37_02695	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CFK37_02700	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CFK37_02705	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CFK37_02710	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CFK37_02715	COG0047	phosphoribosylformylglycinamidine synthase activity
CFK37_02720	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CFK37_02725	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CFK37_02730	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CFK37_02735	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CFK37_02740	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CFK37_02745	COG2233	PERMEase
CFK37_02750	COG1028	Short-chain dehydrogenase reductase Sdr
CFK37_02755	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
CFK37_02760	COG2258	MOSC domain
CFK37_02765	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CFK37_02775	COG1012	belongs to the aldehyde dehydrogenase family
CFK37_02780	COG2252	PERMEase
CFK37_02785	COG0519	Catalyzes the synthesis of GMP from XMP
CFK37_02785	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CFK37_02790	COG1305	Transglutaminase-like
CFK37_02800	COG0714	Associated with various cellular activities
CFK37_02815	COG0531	amino acid
CFK37_02820	COG0697	spore germination
CFK37_02855	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CFK37_02860	COG0584	glycerophosphoryl diester phosphodiesterase
CFK37_02865	COG2356	endonuclease I
CFK37_02870	COG2261	transglycosylase associated protein
CFK37_02875	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CFK37_02880	COG1309	transcriptional regulator
CFK37_02895	COG1012	belongs to the aldehyde dehydrogenase family
CFK37_02925	COG0697	spore germination
CFK37_02930	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CFK37_02935	COG0459	protein refolding
CFK37_02940	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CFK37_02945	COG1266	CAAX protease self-immunity
CFK37_02955	COG0640	Transcriptional regulator
CFK37_02975	COG5504	Zn-dependent protease
CFK37_02985	COG2226	methyltransferase
CFK37_02990	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
CFK37_03000	COG0488	(ABC) transporter
CFK37_03010	COG2801	Transposase and inactivated derivatives
CFK37_03015	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CFK37_03020	COG0456	acetyltransferase
CFK37_03025	COG1214	PFAM Peptidase M22, glycoprotease
CFK37_03030	COG0802	atpase or kinase
CFK37_03035	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
CFK37_03125	COG3091	SprT-like family
CFK37_03130	COG0753	catalase activity
CFK37_03135	COG2183	response to ionizing radiation
CFK37_03140	COG2208	phosphoserine phosphatase activity
CFK37_03145	COG1191	sigma factor activity
CFK37_03150	COG2172	sigma factor antagonist activity
CFK37_03155	COG1366	Belongs to the anti-sigma-factor antagonist family
CFK37_03160	COG2208	phosphoserine phosphatase activity
CFK37_03165	COG2172	sigma factor antagonist activity
CFK37_03170	COG1366	Belongs to the anti-sigma-factor antagonist family
CFK37_03175	COG1366	Belongs to the anti-sigma-factor antagonist family
CFK37_03180	COG2337	Toxic component of a toxin-antitoxin (TA) module
CFK37_03195	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
CFK37_03200	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CFK37_03200	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CFK37_03205	COG0736	holo-[acyl-carrier-protein] synthase activity
CFK37_03210	COG0705	Rhomboid family
CFK37_03215	COG3428	Bacterial PH domain
CFK37_03220	COG3402	PFAM membrane-flanked domain
CFK37_03225	COG0513	Belongs to the DEAD box helicase family
CFK37_03255	COG1846	Transcriptional regulator
CFK37_03275	COG1597	lipid kinase activity
CFK37_03285	COG3850	Histidine kinase
CFK37_03285	COG5002	protein histidine kinase activity
CFK37_03290	COG0745	RESPONSE REGULATOR receiver
CFK37_03300	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CFK37_03310	COG2843	Capsule synthesis protein
CFK37_03315	COG4325	translation initiation factor activity
CFK37_03335	COG1595	DNA-templated transcription, initiation
CFK37_03340	COG1131	(ABC) transporter
CFK37_03345	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
CFK37_03355	COG2188	Transcriptional regulator
CFK37_03360	COG0366	Alpha amylase catalytic
CFK37_03375	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CFK37_03385	COG5002	protein histidine kinase activity
CFK37_03385	COG3850	Histidine kinase
CFK37_03390	COG0745	RESPONSE REGULATOR receiver
CFK37_03395	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CFK37_03400	COG3064	Membrane
CFK37_03405	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
CFK37_03410	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CFK37_03415	COG2153	protein acetylation
CFK37_03420	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CFK37_03425	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CFK37_03430	COG2084	Dehydrogenase
CFK37_03440	COG2226	methyltransferase
CFK37_03445	COG1278	Cold shock
CFK37_03450	COG1765	OsmC-like protein
CFK37_03460	COG2217	Heavy metal translocating P-type atpase
CFK37_03465	COG1937	Protein conserved in bacteria
CFK37_03505	COG2132	Multicopper oxidase
CFK37_03510	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CFK37_03525	COG1388	LysM domain
CFK37_03525	COG0791	NLP P60 protein
CFK37_03565	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CFK37_03590	COG1368	sulfuric ester hydrolase activity
CFK37_03605	COG0366	Alpha amylase catalytic
CFK37_03615	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CFK37_03635	COG0640	Transcriptional regulator
CFK37_03645	COG0534	Mate efflux family protein
CFK37_03685	COG5002	protein histidine kinase activity
CFK37_03690	COG0745	RESPONSE REGULATOR receiver
CFK37_03700	COG0785	Cytochrome C biogenesis protein
CFK37_03705	COG0860	N-Acetylmuramoyl-L-alanine amidase
CFK37_03710	COG1388	LysM domain
CFK37_03730	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
CFK37_03740	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
CFK37_03775	COG0551	DNA topoisomerase type I activity
CFK37_03775	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CFK37_03805	COG1196	nuclear chromosome segregation
CFK37_03805	COG0741	lytic transglycosylase activity
CFK37_03805	COG0739	heme binding
CFK37_03890	COG1742	UPF0060 membrane protein
CFK37_03895	COG0492	ferredoxin-NADP+ reductase activity
CFK37_03900	COG0640	Transcriptional regulator
CFK37_03920	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CFK37_03925	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CFK37_03930	COG0640	Transcriptional regulator
CFK37_04010	COG0386	Belongs to the glutathione peroxidase family
CFK37_04015	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CFK37_04030	COG1028	Short-chain dehydrogenase reductase Sdr
CFK37_04035	COG0351	phosphomethylpyrimidine kinase
CFK37_04040	COG2839	Protein conserved in bacteria
CFK37_04045	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CFK37_04050	COG1876	peptidase activity
CFK37_04055	COG0346	lactoylglutathione lyase activity
CFK37_04070	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CFK37_04075	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CFK37_04080	COG0765	amino acid transport
CFK37_04085	COG0765	amino acid transport
CFK37_04090	COG1126	abc transporter atp-binding protein
CFK37_04095	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CFK37_04105	COG2832	Protein of unknown function (DUF454)
CFK37_04110	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CFK37_04115	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
CFK37_04120	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CFK37_04130	COG0131	Imidazoleglycerol-phosphate dehydratase
CFK37_04135	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CFK37_04140	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CFK37_04145	COG0107	imidazoleglycerol-phosphate synthase activity
CFK37_04150	COG0140	phosphoribosyl-ATP diphosphatase activity
CFK37_04150	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CFK37_04155	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CFK37_04160	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CFK37_04165	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
CFK37_04170	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CFK37_04175	COG4876	unkown
CFK37_04180	COG2720	vancomycin resistance protein
CFK37_04185	COG1304	FMN binding
CFK37_04190	COG2514	catechol 2,3-dioxygenase activity
CFK37_04200	COG3226	Transcriptional regulator
CFK37_04215	COG0656	L-ascorbic acid biosynthetic process
CFK37_04220	COG0488	(ABC) transporter
CFK37_04230	COG0154	amidase activity
CFK37_04240	COG1268	BioY protein
CFK37_04245	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CFK37_04250	COG0519	Catalyzes the synthesis of GMP from XMP
CFK37_04260	COG2195	Cleaves the N-terminal amino acid of tripeptides
CFK37_04265	COG0702	epimerase
CFK37_04270	COG0400	carboxylic ester hydrolase activity
CFK37_04275	COG1876	peptidase activity
CFK37_04280	COG1418	mRNA catabolic process
CFK37_04285	COG1349	DNA-binding transcription factor activity
CFK37_04290	COG1105	Belongs to the carbohydrate kinase PfkB family
CFK37_04295	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CFK37_04295	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CFK37_04295	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CFK37_04305	COG0488	(ABC) transporter
CFK37_04315	COG0778	Nitroreductase
CFK37_04320	COG1181	Belongs to the D-alanine--D-alanine ligase family
CFK37_04325	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CFK37_04330	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CFK37_04330	COG0512	Glutamine amidotransferase of anthranilate synthase
CFK37_04335	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CFK37_04345	COG0133	tryptophan synthase activity
CFK37_04350	COG0159	tryptophan synthase activity
CFK37_04355	COG2207	Transcriptional regulator
CFK37_04355	COG3708	Transcriptional regulator
CFK37_04375	COG0095	Lipoate-protein ligase
CFK37_04380	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CFK37_04390	COG1028	Short-chain dehydrogenase reductase Sdr
CFK37_04400	COG3973	AAA domain
CFK37_04405	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CFK37_04450	COG1131	(ABC) transporter
CFK37_04455	COG1725	Transcriptional regulator
CFK37_04470	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CFK37_04485	COG5577	PFAM Coat F domain
CFK37_04490	COG3104	oligopeptide transport
CFK37_04495	COG1368	sulfuric ester hydrolase activity
CFK37_04525	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CFK37_04530	COG0583	DNA-binding transcription factor activity
CFK37_04535	COG2855	membrane
CFK37_04550	COG1525	nuclease
CFK37_04550	COG4085	toxin activity
CFK37_04550	COG0737	Belongs to the 5'-nucleotidase family
CFK37_04560	COG0456	acetyltransferase
CFK37_04560	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
CFK37_04570	COG0789	Transcriptional regulator
CFK37_04590	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CFK37_04595	COG1366	Belongs to the anti-sigma-factor antagonist family
CFK37_04605	COG3118	belongs to the thioredoxin family
CFK37_04620	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CFK37_04640	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
CFK37_04655	COG4187	Peptidase family M20/M25/M40
CFK37_04660	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CFK37_04665	COG1473	amidohydrolase
CFK37_04675	COG1388	LysM domain
CFK37_04675	COG3858	chitin binding
CFK37_04685	COG2337	Toxic component of a toxin-antitoxin (TA) module
CFK37_04690	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
CFK37_04705	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
CFK37_04720	COG1051	belongs to the nudix hydrolase family
CFK37_04725	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CFK37_04730	COG0110	maltose O-acetyltransferase activity
CFK37_04740	COG1413	lyase activity
CFK37_04745	COG0667	Aldo Keto reductase
CFK37_04755	COG2032	superoxide dismutase activity
CFK37_04765	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CFK37_04770	COG0346	lactoylglutathione lyase activity
CFK37_04780	COG0861	Integral membrane protein TerC family
CFK37_04790	COG1802	Transcriptional regulator
CFK37_04795	COG1114	Component of the transport system for branched-chain amino acids
CFK37_04825	COG1619	proteins homologs of microcin C7 resistance protein MccF
CFK37_04830	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CFK37_04840	COG0737	Belongs to the 5'-nucleotidase family
CFK37_04850	COG1573	uracil-dna glycosylase
CFK37_04855	COG0165	Argininosuccinate lyase
CFK37_04860	COG0137	argininosuccinate synthase activity
CFK37_04865	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CFK37_04870	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CFK37_04875	COG0505	Belongs to the CarA family
CFK37_04885	COG0626	cystathionine gamma-synthase activity
CFK37_04890	COG0626	cystathionine gamma-synthase activity
CFK37_04895	COG2027	D-alanyl-D-alanine carboxypeptidase
CFK37_04900	COG1119	ATPase activity
CFK37_04915	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CFK37_04925	COG1136	(ABC) transporter
CFK37_04930	COG0577	efflux transmembrane transporter activity
CFK37_04935	COG5002	protein histidine kinase activity
CFK37_04935	COG3850	Histidine kinase
CFK37_04940	COG0745	RESPONSE REGULATOR receiver
CFK37_04945	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CFK37_04950	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
CFK37_04955	COG5662	AntiSigma factor
CFK37_04960	COG1595	DNA-templated transcription, initiation
CFK37_05065	COG0726	polysaccharide deacetylase
CFK37_05070	COG2194	sulfuric ester hydrolase activity
CFK37_05080	COG0489	protein tyrosine kinase activity
CFK37_05085	COG0860	N-Acetylmuramoyl-L-alanine amidase
CFK37_05115	COG0668	transmembrane transport
CFK37_05135	COG0732	type I restriction modification DNA specificity domain
CFK37_05170	COG2003	Belongs to the UPF0758 family
CFK37_05215	COG1937	Protein conserved in bacteria
CFK37_05225	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CFK37_05230	COG0730	response to heat
CFK37_05235	COG0425	Belongs to the sulfur carrier protein TusA family
CFK37_05240	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CFK37_05240	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CFK37_05245	COG2210	Belongs to the sulfur carrier protein TusA family
CFK37_05250	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CFK37_05250	COG0425	Belongs to the sulfur carrier protein TusA family
CFK37_05255	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CFK37_05260	COG2210	Belongs to the sulfur carrier protein TusA family
CFK37_05270	COG0662	Cupin 2, conserved barrel domain protein
CFK37_05275	COG1309	transcriptional regulator
CFK37_05295	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CFK37_05300	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CFK37_05305	COG0101	tRNA pseudouridine synthase activity
CFK37_05310	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
CFK37_05315	COG1122	ATPase activity
CFK37_05320	COG1122	ATPase activity
CFK37_05325	COG0203	ribosomal protein L17
CFK37_05330	COG0202	RNA polymerase activity
CFK37_05335	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CFK37_05340	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CFK37_05345	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CFK37_05350	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CFK37_05355	COG2163	COG2163 Ribosomal protein L14E L6E L27E
CFK37_05360	COG0563	adenylate kinase activity
CFK37_05365	COG0201	protein transport
CFK37_05370	COG0200	Binds to the 23S rRNA
CFK37_05375	COG1841	ribosomal large subunit assembly
CFK37_05380	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CFK37_05385	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CFK37_05390	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CFK37_05395	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CFK37_05400	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CFK37_05405	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CFK37_05410	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CFK37_05415	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CFK37_05420	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CFK37_05425	COG0255	Belongs to the universal ribosomal protein uL29 family
CFK37_05430	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CFK37_05435	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CFK37_05440	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CFK37_05445	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CFK37_05450	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CFK37_05455	COG0089	rRNA binding
CFK37_05460	COG0088	Forms part of the polypeptide exit tunnel
CFK37_05465	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CFK37_05470	COG0051	transcription antitermination factor activity, RNA binding
CFK37_05475	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CFK37_05480	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CFK37_05485	COG0049	tRNA binding
CFK37_05490	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CFK37_05495	COG1358	cellular component organization or biogenesis
CFK37_05500	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CFK37_05505	COG0085	RNA polymerase activity
CFK37_05510	COG2813	Specifically methylates the guanine in position
CFK37_05520	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CFK37_05525	COG0081	regulation of translation
CFK37_05535	COG0250	Participates in transcription elongation, termination and antitermination
CFK37_05540	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CFK37_05545	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CFK37_05555	COG3688	RNA-binding protein containing a PIN domain
CFK37_05560	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CFK37_05570	COG0215	cysteine-tRNA ligase activity
CFK37_05575	COG1045	serine acetyltransferase
CFK37_05580	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CFK37_05585	COG4956	integral membrane protein (PIN domain superfamily)
CFK37_05590	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CFK37_05595	COG0542	response to heat
CFK37_05600	COG3869	Catalyzes the specific phosphorylation of arginine residues in
CFK37_05605	COG3880	PFAM UvrB UvrC protein
CFK37_05615	COG1285	pathogenesis
CFK37_05695	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CFK37_05700	COG1396	sequence-specific DNA binding
CFK37_05705	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CFK37_05710	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CFK37_05715	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CFK37_05720	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CFK37_05730	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
CFK37_05735	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
CFK37_05740	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CFK37_05750	COG0037	tRNA processing
CFK37_05755	COG0515	serine threonine protein kinase
CFK37_05760	COG2304	oxidoreductase activity
CFK37_05765	COG2208	phosphoserine phosphatase activity
CFK37_05775	COG2814	Major facilitator Superfamily
CFK37_05785	COG1098	S1 RNA binding domain
CFK37_05805	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
CFK37_05810	COG3956	TIGRFAM MazG family protein
CFK37_05815	COG2244	polysaccharide biosynthetic process
CFK37_05820	COG2002	toxin-antitoxin pair type II binding
CFK37_05825	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CFK37_05835	COG0193	aminoacyl-tRNA hydrolase activity
CFK37_05840	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CFK37_05845	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CFK37_05850	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CFK37_05855	COG2088	sporulation resulting in formation of a cellular spore
CFK37_05860	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CFK37_05865	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CFK37_05870	COG4166	transmembrane transport
CFK37_05875	COG4166	transmembrane transport
CFK37_05885	COG4466	Protein conserved in bacteria
CFK37_05895	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CFK37_05900	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
CFK37_05905	COG3583	domain protein
CFK37_05905	COG3584	3D domain protein
CFK37_05920	COG2002	toxin-antitoxin pair type II binding
CFK37_05925	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CFK37_05930	COG2827	Endonuclease containing a URI domain
CFK37_05935	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
CFK37_05940	COG4467	Involved in initiation control of chromosome replication
CFK37_05945	COG1774	PSP1 C-terminal conserved region
CFK37_05950	COG0470	DNA polymerase III
CFK37_05955	COG3870	Protein conserved in bacteria
CFK37_05960	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CFK37_05965	COG1982	Orn Lys Arg decarboxylase major
CFK37_05970	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CFK37_05990	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CFK37_05995	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CFK37_06000	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CFK37_06010	COG0590	tRNA wobble adenosine to inosine editing
CFK37_06015	COG1335	isochorismatase
CFK37_06020	COG1388	LysM domain
CFK37_06020	COG3858	chitin binding
CFK37_06025	COG0693	protein deglycase activity
CFK37_06030	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CFK37_06040	COG1428	Deoxynucleoside kinase
CFK37_06045	COG1428	Deoxynucleoside kinase
CFK37_06050	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CFK37_06075	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CFK37_06080	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
CFK37_06085	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
CFK37_06095	COG0517	IMP dehydrogenase activity
CFK37_06095	COG0516	GMP reductase activity
CFK37_06110	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CFK37_06115	COG0187	DNA topoisomerase II activity
CFK37_06125	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CFK37_06130	COG2501	S4 domain
CFK37_06135	COG0592	DNA-directed DNA polymerase activity
CFK37_06140	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CFK37_06145	COG0230	Belongs to the bacterial ribosomal protein bL34 family
CFK37_06150	COG0594	ribonuclease P activity
CFK37_06160	COG1847	R3H domain protein
CFK37_06165	COG2234	aminopeptidase activity
CFK37_06170	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CFK37_06175	COG0445	tRNA wobble uridine modification
CFK37_06180	COG0357	Ribosomal RNA small subunit methyltransferase G
CFK37_06185	COG1475	DNA binding
CFK37_06190	COG1192	Involved in chromosome partitioning
CFK37_06195	COG1475	DNA binding
CFK37_06200	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CFK37_06215	COG3949	Membrane
CFK37_06220	COG0668	transmembrane transport
CFK37_06225	COG4481	Protein conserved in bacteria
CFK37_06230	COG0012	GTP binding
CFK37_06235	COG0360	Binds together with S18 to 16S ribosomal RNA
CFK37_06240	COG0629	single-stranded DNA binding
CFK37_06245	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CFK37_06250	COG3832	glyoxalase III activity
CFK37_06265	COG4149	molybdate abc transporter
CFK37_06270	COG0725	ABC transporter, periplasmic molybdate-binding protein
CFK37_06285	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
CFK37_06290	COG0359	binds to the 23S rRNA
CFK37_06295	COG0305	Participates in initiation and elongation during chromosome replication
CFK37_06300	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CFK37_06305	COG0745	RESPONSE REGULATOR receiver
CFK37_06310	COG5002	protein histidine kinase activity
CFK37_06315	COG4863	YycH protein
CFK37_06320	COG4853	Protein conserved in bacteria
CFK37_06325	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CFK37_06330	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CFK37_06335	COG1846	Transcriptional regulator
CFK37_06340	COG1131	(ABC) transporter
CFK37_06390	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CFK37_06395	COG4605	iron ion homeostasis
CFK37_06400	COG4604	ABC transporter, ATP-binding protein
CFK37_06405	COG4607	ABC-type enterochelin transport system periplasmic component
CFK37_06410	COG2154	pterin-4-alpha-carbinolamine dehydratase
CFK37_06420	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CFK37_06430	COG1846	Transcriptional regulator
CFK37_06440	COG2814	Major facilitator Superfamily
CFK37_06485	COG1192	Involved in chromosome partitioning
CFK37_06510	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CFK37_06515	COG1309	transcriptional regulator
CFK37_06525	COG0579	oxidoreductase
CFK37_06530	COG1309	transcriptional regulator
CFK37_06535	COG1131	(ABC) transporter
CFK37_06550	COG0494	nUDIX hydrolase
CFK37_06565	COG0583	DNA-binding transcription factor activity
CFK37_06570	COG1607	acyl-coa hydrolase
CFK37_06590	COG2096	Adenosyltransferase
CFK37_06605	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
CFK37_06610	COG1492	cobalamin metabolic process
CFK37_06615	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
CFK37_06620	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CFK37_06625	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
CFK37_06630	COG1120	ATPase activity
CFK37_06635	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CFK37_06640	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CFK37_06645	COG1028	Short-chain dehydrogenase reductase Sdr
CFK37_06655	COG1695	Transcriptional regulator
CFK37_06670	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CFK37_06685	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
CFK37_06690	COG1122	ATPase activity
CFK37_06695	COG4721	ABC-type cobalt transport system, permease component
CFK37_06715	COG2766	serine protein kinase
CFK37_06720	COG2718	Belongs to the UPF0229 family
CFK37_06735	COG2719	SpoVR family
CFK37_06750	COG1733	regulation of RNA biosynthetic process
CFK37_06770	COG0277	FAD linked oxidase domain protein
CFK37_06805	COG2814	Major facilitator Superfamily
CFK37_06820	COG3246	L-lysine catabolic process to acetate
CFK37_06825	COG1510	regulation of RNA biosynthetic process
CFK37_06830	COG0517	IMP dehydrogenase activity
CFK37_06830	COG1125	glycine betaine transport
CFK37_06835	COG1174	glycine betaine transport
CFK37_06840	COG1732	Glycine betaine
CFK37_06845	COG1174	glycine betaine transport
CFK37_06865	COG1937	Protein conserved in bacteria
CFK37_06870	COG2210	Belongs to the sulfur carrier protein TusA family
CFK37_06875	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CFK37_06880	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CFK37_06880	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CFK37_06885	COG0425	Belongs to the sulfur carrier protein TusA family
CFK37_06890	COG0730	response to heat
CFK37_06895	COG2226	methyltransferase
CFK37_06930	COG1595	DNA-templated transcription, initiation
CFK37_06940	COG0726	polysaccharide deacetylase
CFK37_06950	COG3291	Pkd domain containing protein
CFK37_06950	COG4412	M6 family metalloprotease domain protein
CFK37_06955	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CFK37_06960	COG1301	dicarboxylic acid transport
CFK37_06965	COG2124	cytochrome p450
CFK37_06975	COG1132	(ABC) transporter
CFK37_06985	COG1295	ribonuclease BN
CFK37_06995	COG3695	enzyme binding
CFK37_07000	COG1252	NADH dehydrogenase
CFK37_07010	COG3239	Fatty acid desaturase
CFK37_07015	COG4585	Histidine kinase
CFK37_07020	COG2197	response regulator
CFK37_07025	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CFK37_07035	COG0655	NAD(P)H dehydrogenase (quinone) activity
CFK37_07050	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CFK37_07070	COG2076	Multidrug Resistance protein
CFK37_07075	COG2076	Multidrug Resistance protein
CFK37_07080	COG1309	transcriptional regulator
CFK37_07100	COG2226	methyltransferase
CFK37_07110	COG1757	Na H antiporter
CFK37_07115	COG0628	permease
CFK37_07120	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CFK37_07125	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CFK37_07135	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CFK37_07140	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
CFK37_07155	COG3396	Phenylacetate-CoA oxygenase
CFK37_07170	COG2151	metal-sulfur cluster biosynthetic enzyme
CFK37_07180	COG1024	Enoyl-CoA hydratase
CFK37_07185	COG1024	Enoyl-CoA hydratase
CFK37_07190	COG1250	3-hydroxyacyl-CoA dehydrogenase
CFK37_07195	COG0183	Belongs to the thiolase family
CFK37_07200	COG1024	Enoyl-CoA hydratase
CFK37_07220	COG4120	Belongs to the binding-protein-dependent transport system permease family
CFK37_07225	COG1122	ATPase activity
CFK37_07230	COG4991	sh3 domain protein
CFK37_07230	COG3103	Sh3 type 3 domain protein
CFK37_07230	COG0860	N-Acetylmuramoyl-L-alanine amidase
CFK37_07255	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
CFK37_07260	COG2814	Major facilitator Superfamily
CFK37_07290	COG2070	2-Nitropropane dioxygenase
CFK37_07295	COG0741	lytic transglycosylase activity
CFK37_07295	COG0791	NLP P60 protein
CFK37_07300	COG0251	oxidation-reduction process
CFK37_07305	COG1979	alcohol dehydrogenase
CFK37_07320	COG2814	Major facilitator Superfamily
CFK37_07325	COG4086	secreted protein
CFK37_07330	COG2814	Major facilitator Superfamily
CFK37_07335	COG4166	transmembrane transport
CFK37_07345	COG4166	transmembrane transport
CFK37_07350	COG0601	transmembrane transport
CFK37_07355	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CFK37_07360	COG0444	Belongs to the ABC transporter superfamily
CFK37_07365	COG4608	Belongs to the ABC transporter superfamily
CFK37_07370	COG3584	3D domain protein
CFK37_07370	COG1388	LysM domain
CFK37_07375	COG0156	8-amino-7-oxononanoate synthase activity
CFK37_07380	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CFK37_07385	COG0488	(ABC) transporter
CFK37_07405	COG2755	lipolytic protein G-D-S-L family
CFK37_07410	COG2962	Rard protein
CFK37_07415	COG0626	cystathionine gamma-synthase activity
CFK37_07425	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CFK37_07430	COG1607	acyl-coa hydrolase
CFK37_07435	COG1115	amino acid carrier protein
CFK37_07450	COG2986	histidine ammonia-lyase
CFK37_07455	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
CFK37_07460	COG1228	amidohydrolase
CFK37_07465	COG0010	Belongs to the arginase family
CFK37_07470	COG1733	regulation of RNA biosynthetic process
CFK37_07485	COG0514	ATP-dependent DNA helicase (RecQ)
CFK37_07495	COG1114	Component of the transport system for branched-chain amino acids
CFK37_07515	COG0628	permease
CFK37_07520	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CFK37_07530	COG1764	response to oxidative stress
CFK37_07540	COG3594	Acyltransferase
CFK37_07560	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CFK37_07575	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CFK37_07585	COG0069	glutamate synthase activity
CFK37_07595	COG2363	Small membrane protein
CFK37_07610	COG3773	Cell wall hydrolase
CFK37_07620	COG0280	phosphate acetyltransferase
CFK37_07625	COG0095	Lipoate-protein ligase
CFK37_07630	COG1078	dGTPase activity
CFK37_07635	COG3465	dGTPase activity
CFK37_07650	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CFK37_07660	COG0010	Belongs to the arginase family
CFK37_07670	COG0681	Belongs to the peptidase S26 family
CFK37_07685	COG0018	arginyl-trna synthetase
CFK37_07700	COG2181	nitrate reductase activity
CFK37_07700	COG0247	lactate metabolic process
CFK37_07705	COG0183	Belongs to the thiolase family
CFK37_07710	COG1250	3-hydroxyacyl-CoA dehydrogenase
CFK37_07715	COG1960	acyl-CoA dehydrogenase activity
CFK37_07720	COG1960	acyl-CoA dehydrogenase activity
CFK37_07735	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CFK37_07735	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CFK37_07735	COG1703	isobutyryl-CoA mutase activity
CFK37_07740	COG3343	RNA polymerase activity
CFK37_07745	COG0504	CTP synthase activity
CFK37_07750	COG2204	response regulator
CFK37_07755	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CFK37_07760	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CFK37_07765	COG1494	fructose-1,6-bisphosphatase
CFK37_07770	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CFK37_07775	COG0254	rRNA binding
CFK37_07780	COG1435	thymidine kinase activity
CFK37_07785	COG0069	glutamate synthase activity
CFK37_07790	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CFK37_07795	COG2890	protein-(glutamine-N5) methyltransferase activity
CFK37_07810	COG0009	L-threonylcarbamoyladenylate synthase
CFK37_07815	COG1971	Probably functions as a manganese efflux pump
CFK37_07820	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CFK37_07825	COG0698	ribose 5-phosphate isomerase
CFK37_07830	COG4475	Protein of unknown function (DUF436)
CFK37_07835	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CFK37_07840	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CFK37_07845	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CFK37_07850	COG1404	Belongs to the peptidase S8 family
CFK37_07865	COG0356	it plays a direct role in the translocation of protons across the membrane
CFK37_07870	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CFK37_07875	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CFK37_07880	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CFK37_07885	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CFK37_07890	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CFK37_07895	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CFK37_07900	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CFK37_07920	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CFK37_07925	COG1619	proteins homologs of microcin C7 resistance protein MccF
CFK37_07930	COG0791	NLP P60 protein
CFK37_07935	COG2385	sporulation resulting in formation of a cellular spore
CFK37_07940	COG0739	heme binding
CFK37_07960	COG1077	Cell shape determining protein MreB Mrl
CFK37_07970	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CFK37_08070	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CFK37_08100	COG1131	(ABC) transporter
CFK37_08110	COG1309	transcriptional regulator
CFK37_08115	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CFK37_08130	COG0531	amino acid
CFK37_08135	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CFK37_08155	COG2244	polysaccharide biosynthetic process
CFK37_08170	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
CFK37_08175	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CFK37_08180	COG4193	domain, Protein
CFK37_08180	COG3266	domain, Protein
CFK37_08180	COG5632	N-Acetylmuramoyl-L-alanine amidase
CFK37_08185	COG0438	transferase activity, transferring glycosyl groups
CFK37_08190	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
CFK37_08195	COG1682	transport, permease protein
CFK37_08200	COG1134	teichoic acid transport
CFK37_08205	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CFK37_08210	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CFK37_08215	COG0318	PFAM AMP-dependent synthetase and ligase
CFK37_08220	COG0824	Thioesterase
CFK37_08225	COG2186	Transcriptional regulator
CFK37_08235	COG0579	oxidoreductase
CFK37_08240	COG1522	sequence-specific DNA binding
CFK37_08255	COG0747	negative chemotaxis
CFK37_08260	COG0444	Belongs to the ABC transporter superfamily
CFK37_08265	COG4608	Belongs to the ABC transporter superfamily
CFK37_08285	COG0405	Gamma-glutamyltransferase
CFK37_08290	COG2059	Chromate
CFK37_08295	COG2059	Chromate
CFK37_08305	COG0728	peptidoglycan biosynthetic process
CFK37_08315	COG0438	transferase activity, transferring glycosyl groups
CFK37_08320	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CFK37_08325	COG1316	TRANSCRIPTIONal
CFK37_08330	COG0584	glycerophosphoryl diester phosphodiesterase
CFK37_08335	COG0646	methionine synthase
CFK37_08335	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
CFK37_08345	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CFK37_08350	COG0175	sulfate reduction
CFK37_08355	COG0306	phosphate transporter
CFK37_08360	COG2046	Belongs to the sulfate adenylyltransferase family
CFK37_08365	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
CFK37_08370	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CFK37_08375	COG0529	Catalyzes the synthesis of activated sulfate
CFK37_08410	COG1940	carbohydrate kinase activity
CFK37_08415	COG2017	converts alpha-aldose to the beta-anomer
CFK37_08420	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
CFK37_08425	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CFK37_08435	COG2814	Major facilitator Superfamily
CFK37_08460	COG1486	melibiose metabolic process
CFK37_08465	COG1940	carbohydrate kinase activity
CFK37_08470	COG1653	transport
CFK37_08485	COG0673	inositol 2-dehydrogenase activity
CFK37_08500	COG1262	PFAM Formylglycine-generating sulfatase enzyme
CFK37_08505	COG1609	Transcriptional regulator
CFK37_08520	COG0366	Alpha amylase catalytic
CFK37_08555	COG1917	Cupin 2, conserved barrel domain protein
CFK37_08555	COG2207	Transcriptional regulator
CFK37_08565	COG5578	integral membrane protein
CFK37_08570	COG2207	Transcriptional regulator
CFK37_08575	COG4209	transmembrane transport
CFK37_08580	COG0395	ABC-type sugar transport system, permease component
CFK37_08595	COG0383	alpha-mannosidase activity
CFK37_08635	COG1082	Xylose isomerase domain protein TIM barrel
CFK37_08640	COG0673	inositol 2-dehydrogenase activity
CFK37_08645	COG3119	arylsulfatase activity
CFK37_08655	COG3250	beta-galactosidase activity
CFK37_08690	COG2222	sugar isomerase
CFK37_08700	COG1105	Belongs to the carbohydrate kinase PfkB family
CFK37_08715	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CFK37_08725	COG0024	Methionine aminopeptidase
CFK37_08760	COG0277	FAD linked oxidase domain protein
CFK37_08810	COG2336	PFAM SpoVT AbrB
CFK37_08815	COG2337	Toxic component of a toxin-antitoxin (TA) module
CFK37_08825	COG2814	Major facilitator Superfamily
CFK37_08830	COG1846	Transcriptional regulator
CFK37_08835	COG2706	6-phosphogluconolactonase activity
CFK37_08845	COG0860	N-Acetylmuramoyl-L-alanine amidase
CFK37_08855	COG0668	transmembrane transport
CFK37_08865	COG1597	lipid kinase activity
CFK37_08870	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CFK37_08885	COG1366	Belongs to the anti-sigma-factor antagonist family
CFK37_08890	COG2172	sigma factor antagonist activity
CFK37_08895	COG1733	regulation of RNA biosynthetic process
CFK37_08930	COG1388	LysM domain
CFK37_08930	COG0791	NLP P60 protein
CFK37_08935	COG3944	biosynthesis protein
CFK37_08940	COG0489	protein tyrosine kinase activity
CFK37_08945	COG4464	protein tyrosine phosphatase activity
CFK37_08950	COG4464	protein tyrosine phosphatase activity
CFK37_08980	COG0110	maltose O-acetyltransferase activity
CFK37_09005	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CFK37_09010	COG0110	maltose O-acetyltransferase activity
CFK37_09015	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CFK37_09020	COG1316	TRANSCRIPTIONal
CFK37_09060	COG1228	amidohydrolase
CFK37_09075	COG2972	Histidine kinase
CFK37_09080	COG3279	Response regulator of the LytR AlgR family
CFK37_09085	COG1879	ABC-type sugar transport system periplasmic component
CFK37_09090	COG1129	ABC transporter
CFK37_09095	COG1172	Belongs to the binding-protein-dependent transport system permease family
CFK37_09100	COG1172	Belongs to the binding-protein-dependent transport system permease family
CFK37_09105	COG3250	beta-galactosidase activity
CFK37_09110	COG3940	Belongs to the glycosyl hydrolase 43 family
CFK37_09140	COG2186	Transcriptional regulator
CFK37_09150	COG4145	pantothenate transmembrane transporter activity
CFK37_09160	COG0473	3-isopropylmalate dehydrogenase activity
CFK37_09170	COG1012	belongs to the aldehyde dehydrogenase family
CFK37_09175	COG1802	Transcriptional regulator
CFK37_09200	COG2409	Drug exporters of the RND superfamily
CFK37_09210	COG1472	Belongs to the glycosyl hydrolase 3 family
CFK37_09220	COG3876	Protein conserved in bacteria
CFK37_09230	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CFK37_09240	COG3829	transcription factor binding
CFK37_09240	COG3290	protein histidine kinase activity
CFK37_09250	COG0601	transmembrane transport
CFK37_09255	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CFK37_09260	COG0444	Belongs to the ABC transporter superfamily
CFK37_09265	COG4608	Belongs to the ABC transporter superfamily
CFK37_09275	COG2362	D-Aminopeptidase
CFK37_09295	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CFK37_09300	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
CFK37_09305	COG1757	Na H antiporter
CFK37_09310	COG1012	belongs to the aldehyde dehydrogenase family
CFK37_09315	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CFK37_09325	COG3938	Belongs to the proline racemase family
CFK37_09335	COG3290	protein histidine kinase activity
CFK37_09335	COG3829	transcription factor binding
CFK37_09360	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CFK37_09365	COG0583	DNA-binding transcription factor activity
CFK37_09380	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
CFK37_09390	COG2113	Glycine betaine
CFK37_09395	COG1510	regulation of RNA biosynthetic process
CFK37_09405	COG1309	transcriptional regulator
CFK37_09450	COG1266	CAAX protease self-immunity
CFK37_09465	COG0596	Alpha beta hydrolase
CFK37_09490	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CFK37_09490	COG1042	CoA-binding domain protein
CFK37_09490	COG0045	succinate-CoA ligase (ADP-forming) activity
CFK37_09495	COG2030	dehydratase
CFK37_09515	COG1960	acyl-CoA dehydrogenase activity
CFK37_09520	COG1960	acyl-CoA dehydrogenase activity
CFK37_09530	COG2814	Major facilitator Superfamily
CFK37_09565	COG1473	amidohydrolase
CFK37_09570	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
CFK37_09575	COG1473	amidohydrolase
CFK37_09580	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CFK37_09590	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CFK37_09620	COG0477	Major facilitator Superfamily
CFK37_09635	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CFK37_09645	COG3764	Sortase (surface protein transpeptidase)
CFK37_09655	COG0791	NLP P60 protein
CFK37_09670	COG3395	kinase activity
CFK37_09675	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
CFK37_09680	COG3394	polysaccharide catabolic process
CFK37_09690	COG1486	melibiose metabolic process
CFK37_09700	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CFK37_09705	COG1447	Phosphotransferase system cellobiose-specific component IIA
CFK37_09710	COG2723	6-phospho-beta-galactosidase activity
CFK37_09725	COG0235	Class ii aldolase
CFK37_09735	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CFK37_09755	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CFK37_09780	COG0737	Belongs to the 5'-nucleotidase family
CFK37_09790	COG1335	isochorismatase
CFK37_09800	COG0328	RNA-DNA hybrid ribonuclease activity
CFK37_09805	COG0534	Mate efflux family protein
CFK37_09810	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
CFK37_09815	COG1984	allophanate hydrolase subunit 2
CFK37_09820	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
CFK37_09825	COG1914	H( )-stimulated, divalent metal cation uptake system
CFK37_09830	COG4336	lyase activity
CFK37_09835	COG1757	Na H antiporter
CFK37_09840	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CFK37_09845	COG2610	gluconate transmembrane transporter activity
CFK37_09855	COG3829	transcription factor binding
CFK37_09855	COG3290	protein histidine kinase activity
CFK37_09865	COG1024	Enoyl-CoA hydratase
CFK37_09870	COG4145	pantothenate transmembrane transporter activity
CFK37_09890	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
CFK37_09890	COG0167	dihydroorotate dehydrogenase activity
CFK37_09910	COG2508	Transcriptional regulator
CFK37_09915	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CFK37_09920	COG1012	belongs to the aldehyde dehydrogenase family
CFK37_09925	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CFK37_09940	COG1473	amidohydrolase
CFK37_09950	COG1288	antiporter activity
CFK37_09955	COG1473	amidohydrolase
CFK37_09975	COG1620	l-lactate permease
CFK37_09980	COG2186	Transcriptional regulator
CFK37_09985	COG0247	lactate metabolic process
CFK37_09990	COG1139	Iron-sulfur cluster binding protein
CFK37_09995	COG1556	Lactate utilization protein
CFK37_10000	COG0583	DNA-binding transcription factor activity
CFK37_10005	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
CFK37_10010	COG2186	Transcriptional regulator
CFK37_10015	COG0277	FAD linked oxidase domain protein
CFK37_10020	COG0247	lactate metabolic process
CFK37_10025	COG0277	FAD linked oxidase domain protein
CFK37_10030	COG0179	Fumarylacetoacetate (FAA) hydrolase
CFK37_10035	COG1620	l-lactate permease
CFK37_10040	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CFK37_10060	COG3579	cysteine-type endopeptidase activity
CFK37_10095	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CFK37_10110	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CFK37_10115	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CFK37_10120	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CFK37_10130	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CFK37_10140	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CFK37_10160	COG0561	phosphatase activity
CFK37_10170	COG3162	membrane
CFK37_10175	COG3279	Response regulator of the LytR AlgR family
CFK37_10180	COG3275	phosphorelay sensor kinase activity
CFK37_10185	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CFK37_10195	COG1737	Transcriptional regulator
CFK37_10200	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CFK37_10205	COG0800	Aldolase
CFK37_10210	COG4948	Mandelate Racemase Muconate Lactonizing
CFK37_10215	COG2610	gluconate transmembrane transporter activity
CFK37_10220	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CFK37_10230	COG0066	3-isopropylmalate dehydratase activity
CFK37_10240	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CFK37_10245	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CFK37_10250	COG1802	Transcriptional regulator
CFK37_10260	COG1482	cell wall glycoprotein biosynthetic process
CFK37_10270	COG2972	Histidine kinase
CFK37_10275	COG2207	Transcriptional regulator
CFK37_10275	COG4753	response regulator
CFK37_10285	COG1175	transmembrane transport
CFK37_10295	COG1940	carbohydrate kinase activity
CFK37_10305	COG3711	transcriptional antiterminator
CFK37_10315	COG0246	Mannitol dehydrogenase
CFK37_10335	COG4166	transmembrane transport
CFK37_10340	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CFK37_10345	COG0006	proline dipeptidase activity
CFK37_10350	COG1940	carbohydrate kinase activity
CFK37_10355	COG1840	ABC-type Fe3 transport system, periplasmic component
CFK37_10360	COG3842	ATPase activity
CFK37_10370	COG0165	Argininosuccinate lyase
CFK37_10385	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
CFK37_10385	COG2508	Transcriptional regulator
CFK37_10390	COG0686	Belongs to the AlaDH PNT family
CFK37_10400	COG3493	citrate carrier protein
CFK37_10405	COG4565	transcriptional regulatory protein
CFK37_10410	COG3290	protein histidine kinase activity
CFK37_10420	COG1940	carbohydrate kinase activity
CFK37_10430	COG4166	transmembrane transport
CFK37_10435	COG3142	Participates in the control of copper homeostasis
CFK37_10445	COG0720	synthase
CFK37_10450	COG0602	queuosine metabolic process
CFK37_10455	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CFK37_10460	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CFK37_10465	COG3414	Phosphotransferase system galactitol-specific IIB component
CFK37_10470	COG3775	system Galactitol-specific IIC component
CFK37_10475	COG1063	alcohol dehydrogenase
CFK37_10480	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CFK37_10485	COG1063	alcohol dehydrogenase
CFK37_10490	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CFK37_10505	COG0686	Belongs to the AlaDH PNT family
CFK37_10510	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CFK37_10515	COG0583	DNA-binding transcription factor activity
CFK37_10525	COG1363	Peptidase, m42
CFK37_10550	COG4166	transmembrane transport
CFK37_10555	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
CFK37_10560	COG2368	4-hydroxyphenylacetate
CFK37_10565	COG0179	Fumarylacetoacetate (FAA) hydrolase
CFK37_10575	COG1960	acyl-CoA dehydrogenase activity
CFK37_10590	COG1473	amidohydrolase
CFK37_10595	COG0702	epimerase
CFK37_10600	COG1609	Transcriptional regulator
CFK37_10605	COG1028	Short-chain dehydrogenase reductase Sdr
CFK37_10610	COG1653	transport
CFK37_10615	COG1653	transport
CFK37_10630	COG0673	inositol 2-dehydrogenase activity
CFK37_10635	COG0673	inositol 2-dehydrogenase activity
CFK37_10650	COG0673	inositol 2-dehydrogenase activity
CFK37_10655	COG1082	Xylose isomerase domain protein TIM barrel
CFK37_10660	COG4166	transmembrane transport
CFK37_10665	COG1827	regulation of RNA biosynthetic process
CFK37_10670	COG1104	cysteine desulfurase activity
CFK37_10680	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
CFK37_10685	COG0157	Belongs to the NadC ModD family
CFK37_10690	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
CFK37_10695	COG2267	carboxylic ester hydrolase activity
CFK37_10710	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CFK37_10715	COG2076	Multidrug Resistance protein
CFK37_10725	COG0463	Glycosyl transferase, family 2
CFK37_10730	COG1088	dTDP-glucose 4,6-dehydratase activity
CFK37_10760	COG1136	(ABC) transporter
CFK37_10770	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CFK37_10775	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CFK37_10780	COG2376	Dihydroxyacetone kinase
CFK37_10785	COG1461	Dihydroxyacetone kinase
CFK37_10790	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
CFK37_10800	COG0561	phosphatase activity
CFK37_10805	COG0436	Aminotransferase
CFK37_10810	COG4895	conserved protein (DUF2196)
CFK37_10830	COG2094	Belongs to the DNA glycosylase MPG family
CFK37_10835	COG1126	abc transporter atp-binding protein
CFK37_10840	COG0765	amino acid transport
CFK37_10845	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CFK37_10850	COG2996	Protein conserved in bacteria
CFK37_10880	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CFK37_10885	COG1012	belongs to the aldehyde dehydrogenase family
CFK37_10915	COG0022	dehydrogenase e1 component
CFK37_10935	COG0179	Fumarylacetoacetate (FAA) hydrolase
CFK37_10955	COG2814	Major facilitator Superfamily
CFK37_10960	COG1028	Short-chain dehydrogenase reductase Sdr
CFK37_10970	COG1971	Probably functions as a manganese efflux pump
CFK37_10990	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
CFK37_10995	COG1140	nitrate reductase beta subunit
CFK37_11005	COG2181	nitrate reductase activity
CFK37_11020	COG1959	2 iron, 2 sulfur cluster binding
CFK37_11025	COG1017	nitric oxide dioxygenase activity
CFK37_11025	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CFK37_11030	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CFK37_11035	COG1380	Effector of murein hydrolase LrgA
CFK37_11040	COG1346	cytolysis
CFK37_11055	COG3290	protein histidine kinase activity
CFK37_11060	COG4565	transcriptional regulatory protein
CFK37_11065	COG3181	Tripartite tricarboxylate transporter family receptor
CFK37_11080	COG0431	NADPH-dependent FMN reductase
CFK37_11080	COG1053	succinate dehydrogenase
CFK37_11080	COG3976	FMN-binding domain protein
CFK37_11095	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CFK37_11110	COG1574	metal-dependent hydrolase with the TIM-barrel fold
CFK37_11130	COG1175	transmembrane transport
CFK37_11135	COG3833	ABC-type maltose transport systems, permease component
CFK37_11145	COG1609	Transcriptional regulator
CFK37_11155	COG0716	FMN binding
CFK37_11160	COG4948	Mandelate Racemase Muconate Lactonizing
CFK37_11165	COG0697	spore germination
CFK37_11170	COG2031	fatty acid transporter
CFK37_11175	COG2971	BadF BadG BcrA BcrD
CFK37_11180	COG1737	Transcriptional regulator
CFK37_11185	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
CFK37_11195	COG1175	transmembrane transport
CFK37_11200	COG0395	ABC-type sugar transport system, permease component
CFK37_11220	COG0010	Belongs to the arginase family
CFK37_11230	COG2197	response regulator
CFK37_11255	COG1794	racemase activity, acting on amino acids and derivatives
CFK37_11260	COG2807	transmembrane transport
CFK37_11265	COG2814	Major facilitator Superfamily
CFK37_11270	COG0672	)-iron permease
CFK37_11275	COG2822	iron ion transport
CFK37_11280	COG2837	iron assimilation
CFK37_11295	COG0183	Belongs to the thiolase family
CFK37_11300	COG0318	PFAM AMP-dependent synthetase and ligase
CFK37_11305	COG1268	BioY protein
CFK37_11310	COG0471	metal ion transport
CFK37_11320	COG2814	Major facilitator Superfamily
CFK37_11325	COG0561	phosphatase activity
CFK37_11335	COG0833	amino acid
CFK37_11340	COG0006	proline dipeptidase activity
CFK37_11355	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CFK37_11360	COG1012	belongs to the aldehyde dehydrogenase family
CFK37_11365	COG1473	amidohydrolase
CFK37_11370	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CFK37_11380	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CFK37_11385	COG0473	3-isopropylmalate dehydrogenase activity
CFK37_11395	COG1012	belongs to the aldehyde dehydrogenase family
CFK37_11405	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CFK37_11420	COG0768	penicillin binding
CFK37_11425	COG1316	TRANSCRIPTIONal
CFK37_11435	COG1396	sequence-specific DNA binding
CFK37_11440	COG4821	SIS domain
CFK37_11460	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CFK37_11465	COG0363	glucosamine-6-phosphate deaminase activity
CFK37_11470	COG1739	Uncharacterized protein family UPF0029
CFK37_11480	COG2197	response regulator
CFK37_11485	COG1307	EDD domain protein, DegV family
CFK37_11490	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
CFK37_11495	COG1040	competence protein
CFK37_11505	COG0653	protein targeting
CFK37_11510	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
CFK37_11520	COG2884	Cell division ATP-binding protein ftsE
CFK37_11525	COG2177	Part of the ABC transporter FtsEX involved in
CFK37_11530	COG0739	heme binding
CFK37_11535	COG0793	Belongs to the peptidase S41A family
CFK37_11535	COG3409	Peptidoglycan-binding domain 1 protein
CFK37_11540	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CFK37_11545	COG0556	nucleotide-excision repair
CFK37_11550	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CFK37_11555	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CFK37_11565	COG1983	PspC domain protein
CFK37_11570	COG1950	PFAM Membrane protein of
CFK37_11575	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
CFK37_11580	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CFK37_11585	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CFK37_11590	COG0546	phosphoglycolate phosphatase activity
CFK37_11595	COG0110	maltose O-acetyltransferase activity
CFK37_11600	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
CFK37_11605	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CFK37_11610	COG0457	Tetratricopeptide repeat
CFK37_11615	COG0492	ferredoxin-NADP+ reductase activity
CFK37_11620	COG1051	belongs to the nudix hydrolase family
CFK37_11625	COG1660	Displays ATPase and GTPase activities
CFK37_11630	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CFK37_11635	COG1481	regulation of sporulation
CFK37_11640	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CFK37_11645	COG0740	serine-type endopeptidase activity
CFK37_11650	COG4166	transmembrane transport
CFK37_11660	COG2112	serine threonine protein kinase
CFK37_11680	COG0126	phosphoglycerate kinase activity
CFK37_11685	COG0149	triose-phosphate isomerase activity
CFK37_11690	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
CFK37_11695	COG0148	phosphopyruvate hydratase activity
CFK37_11720	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CFK37_11725	COG1647	Serine aminopeptidase, S33
CFK37_11730	COG0557	exoribonuclease II activity
CFK37_11735	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CFK37_11750	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CFK37_11760	COG1363	Peptidase, m42
CFK37_11765	COG1309	transcriptional regulator
CFK37_11775	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CFK37_11790	COG0586	Pfam SNARE associated Golgi protein
CFK37_11795	COG1968	undecaprenyl-diphosphatase activity
CFK37_11800	COG1388	LysM domain
CFK37_11805	COG1937	Protein conserved in bacteria
CFK37_11810	COG2217	Heavy metal translocating P-type atpase
CFK37_11835	COG4758	membrane
CFK37_11845	COG2197	response regulator
CFK37_11850	COG2224	Isocitrate lyase
CFK37_11855	COG4129	membrane
CFK37_11860	COG0598	Magnesium transport protein CorA
CFK37_11865	COG0791	NLP P60 protein
CFK37_11865	COG3883	PFAM NLP P60 protein
CFK37_11870	COG0778	Nitroreductase
CFK37_11880	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CFK37_11885	COG2076	Multidrug Resistance protein
CFK37_11890	COG2076	Multidrug Resistance protein
CFK37_11895	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CFK37_11900	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CFK37_11905	COG0735	belongs to the Fur family
CFK37_11910	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CFK37_11915	COG1121	(ABC) transporter
CFK37_11925	COG2608	mercury ion transmembrane transporter activity
CFK37_11930	COG1392	Phosphate transport regulator
CFK37_11935	COG0306	phosphate transporter
CFK37_11945	COG1024	Enoyl-CoA hydratase
CFK37_11945	COG1250	3-hydroxyacyl-CoA dehydrogenase
CFK37_11950	COG0183	Belongs to the thiolase family
CFK37_11955	COG1960	acyl-CoA dehydrogenase activity
CFK37_11960	COG1393	Belongs to the ArsC family
CFK37_11965	COG0509	glycine decarboxylation via glycine cleavage system
CFK37_11970	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
CFK37_11975	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CFK37_11980	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CFK37_11985	COG2011	ABC-type metal ion transport system permease component
CFK37_11990	COG1464	Belongs to the NlpA lipoprotein family
CFK37_11995	COG0396	ATPase activity
CFK37_12000	COG0719	Fe-S assembly protein
CFK37_12005	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CFK37_12010	COG0822	iron-sulfur transferase activity
CFK37_12015	COG0719	Fe-S assembly protein
CFK37_12035	COG0395	ABC-type sugar transport system, permease component
CFK37_12070	COG0737	Belongs to the 5'-nucleotidase family
CFK37_12075	COG3377	Domain of unknown function (DUF1805)
CFK37_12085	COG1757	Na H antiporter
CFK37_12090	COG0733	neurotransmitter:sodium symporter activity
CFK37_12110	COG0739	heme binding
CFK37_12120	COG4470	Protein conserved in bacteria
CFK37_12195	COG0631	protein serine/threonine phosphatase activity
CFK37_12200	COG0515	serine threonine protein kinase
CFK37_12220	COG2304	oxidoreductase activity
CFK37_12235	COG2445	Protein of unknown function DUF86
CFK37_12240	COG0647	UMP catabolic process
CFK37_12245	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
CFK37_12250	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CFK37_12255	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
CFK37_12260	COG4837	Protein of unknown function (DUF1462)
CFK37_12265	COG0316	Belongs to the HesB IscA family
CFK37_12270	COG0492	ferredoxin-NADP+ reductase activity
CFK37_12275	COG1252	NADH dehydrogenase
CFK37_12285	COG3584	3D domain protein
CFK37_12290	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
CFK37_12300	COG0813	purine-nucleoside phosphorylase activity
CFK37_12305	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CFK37_12330	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
CFK37_12335	COG0166	Belongs to the GPI family
CFK37_12340	COG1098	S1 RNA binding domain
CFK37_12350	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CFK37_12365	COG1404	Belongs to the peptidase S8 family
CFK37_12365	COG4412	M6 family metalloprotease domain protein
CFK37_12370	COG1404	Belongs to the peptidase S8 family
CFK37_12370	COG4412	M6 family metalloprotease domain protein
CFK37_12375	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
CFK37_12380	COG0531	amino acid
CFK37_12385	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CFK37_12390	COG2050	protein possibly involved in aromatic compounds catabolism
CFK37_12395	COG1575	Belongs to the MenA family. Type 1 subfamily
CFK37_12400	COG1169	isochorismate synthase
CFK37_12405	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
CFK37_12410	COG0596	Alpha beta hydrolase
CFK37_12415	COG0318	PFAM AMP-dependent synthetase and ligase
CFK37_12420	COG1120	ATPase activity
CFK37_12430	COG0494	nUDIX hydrolase
CFK37_12435	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CFK37_12440	COG1116	anion transmembrane transporter activity
CFK37_12445	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CFK37_12450	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
CFK37_12460	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
CFK37_12470	COG0531	amino acid
CFK37_12475	COG1126	abc transporter atp-binding protein
CFK37_12480	COG0765	amino acid transport
CFK37_12485	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CFK37_12490	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
CFK37_12495	COG0495	leucyl-tRNA aminoacylation
CFK37_12505	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CFK37_12535	COG2244	polysaccharide biosynthetic process
CFK37_12540	COG1187	pseudouridine synthase activity
CFK37_12545	COG1349	DNA-binding transcription factor activity
CFK37_12550	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
CFK37_12555	COG0510	thiamine kinase activity
CFK37_12565	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CFK37_12570	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CFK37_12575	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
CFK37_12580	COG3285	dna ligase
CFK37_12580	COG1793	dna ligase
CFK37_12590	COG1363	Peptidase, m42
CFK37_12595	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
CFK37_12600	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CFK37_12610	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CFK37_12615	COG4848	Belongs to the UPF0354 family
CFK37_12620	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CFK37_12625	COG1674	ftsk spoiiie
CFK37_12635	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CFK37_12645	COG4980	gas vesicle protein
CFK37_12650	COG1605	Chorismate mutase
CFK37_12650	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
CFK37_12660	COG0123	including yeast histone deacetylase and acetoin utilization protein
CFK37_12665	COG0517	IMP dehydrogenase activity
CFK37_12670	COG0454	-acetyltransferase
CFK37_12685	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CFK37_12695	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CFK37_12700	COG2199	diguanylate cyclase activity
CFK37_12700	COG2203	Gaf domain
CFK37_12705	COG1956	GAF domain-containing protein
CFK37_12710	COG1309	transcriptional regulator
CFK37_12715	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
CFK37_12720	COG1104	cysteine desulfurase activity
CFK37_12725	COG0301	tRNA thio-modification
CFK37_12735	COG1574	metal-dependent hydrolase with the TIM-barrel fold
CFK37_12740	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CFK37_12750	COG3874	Sporulation protein YtfJ
CFK37_12755	COG0827	DNA restriction-modification system
CFK37_12760	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CFK37_12765	COG0521	Mo-molybdopterin cofactor biosynthetic process
CFK37_12770	COG0589	response to stress
CFK37_12775	COG0686	Belongs to the AlaDH PNT family
CFK37_12780	COG0006	proline dipeptidase activity
CFK37_12790	COG1842	Phage shock protein A
CFK37_12800	COG3766	membrane
CFK37_12805	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CFK37_12810	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CFK37_12850	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
CFK37_12870	COG2814	Major facilitator Superfamily
CFK37_12880	COG4109	DRTGG domain
CFK37_12890	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
CFK37_12910	COG0587	DNA-directed DNA polymerase activity
CFK37_12915	COG0281	malic enzyme
CFK37_12920	COG2186	Transcriptional regulator
CFK37_12925	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CFK37_12930	COG0825	malonyl-CoA metabolic process
CFK37_12935	COG0205	6-phosphofructokinase activity
CFK37_12945	COG3030	protein affecting phage T7 exclusion by the F plasmid
CFK37_12950	COG0628	permease
CFK37_12955	COG0372	Belongs to the citrate synthase family
CFK37_12960	COG0538	isocitrate dehydrogenase activity
CFK37_12965	COG0039	L-malate dehydrogenase activity
CFK37_12975	COG0745	RESPONSE REGULATOR receiver
CFK37_12980	COG5002	protein histidine kinase activity
CFK37_12985	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CFK37_12985	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CFK37_12990	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CFK37_13000	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CFK37_13005	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
CFK37_13015	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CFK37_13020	COG3611	Membrane attachment protein
CFK37_13025	COG1484	DNA-dependent DNA replication
CFK37_13035	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CFK37_13040	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CFK37_13045	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CFK37_13050	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CFK37_13060	COG0398	Pfam SNARE associated Golgi protein
CFK37_13075	COG1363	Peptidase, m42
CFK37_13080	COG1131	(ABC) transporter
CFK37_13105	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CFK37_13110	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CFK37_13115	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CFK37_13115	COG0072	phenylalanine-tRNA ligase activity
CFK37_13120	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CFK37_13125	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
CFK37_13130	COG1286	toxin biosynthetic process
CFK37_13135	COG1796	DNA polymerase
CFK37_13135	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CFK37_13140	COG1193	negative regulation of DNA recombination
CFK37_13145	COG3766	membrane
CFK37_13150	COG0318	PFAM AMP-dependent synthetase and ligase
CFK37_13155	COG1309	transcriptional regulator
CFK37_13160	COG1024	Enoyl-CoA hydratase
CFK37_13165	COG2086	electron transfer activity
CFK37_13170	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CFK37_13175	COG3118	belongs to the thioredoxin family
CFK37_13180	COG0322	excinuclease ABC activity
CFK37_13185	COG1719	4-vinyl reductase, 4VR
CFK37_13190	COG2009	succinate dehydrogenase
CFK37_13195	COG1053	succinate dehydrogenase
CFK37_13200	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CFK37_13205	COG0824	Thioesterase
CFK37_13210	COG2197	response regulator
CFK37_13215	COG1846	Transcriptional regulator
CFK37_13220	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CFK37_13225	COG5401	PFAM Sporulation and spore germination
CFK37_13230	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
CFK37_13235	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CFK37_13240	COG0622	Phosphoesterase
CFK37_13260	COG0544	peptidyl-prolyl cis-trans isomerase activity
CFK37_13265	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CFK37_13275	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CFK37_13280	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CFK37_13290	COG1126	abc transporter atp-binding protein
CFK37_13300	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CFK37_13305	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CFK37_13310	COG0181	hydroxymethylbilane synthase activity
CFK37_13320	COG0113	porphobilinogen synthase activity
CFK37_13325	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CFK37_13330	COG1388	LysM domain
CFK37_13330	COG1388	LysM domain
CFK37_13345	COG0525	valine-tRNA ligase activity
CFK37_13355	COG4067	protein conserved in archaea
CFK37_13355	COG0189	ligase activity
CFK37_13360	COG0285	dihydrofolate synthase activity
CFK37_13370	COG2003	Belongs to the UPF0758 family
CFK37_13375	COG1077	Cell shape determining protein MreB Mrl
CFK37_13380	COG1792	Involved in formation and maintenance of cell shape
CFK37_13390	COG0850	regulation of cytokinetic process
CFK37_13395	COG2894	cell division
CFK37_13405	COG1994	Peptidase M50
CFK37_13410	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CFK37_13415	COG2868	ribosomal protein
CFK37_13420	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CFK37_13440	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CFK37_13450	COG0217	transcriptional regulatory protein
CFK37_13455	COG0632	four-way junction helicase activity
CFK37_13460	COG2255	four-way junction helicase activity
CFK37_13470	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CFK37_13475	COG0343	queuine tRNA-ribosyltransferase activity
CFK37_13480	COG1862	Preprotein translocase
CFK37_13490	COG2244	polysaccharide biosynthetic process
CFK37_13500	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CFK37_13500	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CFK37_13505	COG5416	Lipopolysaccharide assembly protein A domain
CFK37_13510	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CFK37_13510	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
CFK37_13515	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CFK37_13520	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CFK37_13525	COG1490	D-aminoacyl-tRNA deacylase activity
CFK37_13530	COG0860	N-Acetylmuramoyl-L-alanine amidase
CFK37_13530	COG3103	Sh3 type 3 domain protein
CFK37_13530	COG4991	sh3 domain protein
CFK37_13535	COG0124	histidyl-tRNA synthetase
CFK37_13540	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CFK37_13555	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CFK37_13560	COG1959	2 iron, 2 sulfur cluster binding
CFK37_13565	COG1104	cysteine desulfurase activity
CFK37_13570	COG0482	sulfurtransferase activity
CFK37_13580	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CFK37_13590	COG0628	permease
CFK37_13595	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CFK37_13600	COG4472	Bacterial protein of unknown function (DUF965)
CFK37_13605	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CFK37_13610	COG3906	Belongs to the UPF0473 family
CFK37_13615	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CFK37_13625	COG0572	uridine kinase
CFK37_13630	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CFK37_13640	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CFK37_13645	COG1191	sigma factor activity
CFK37_13655	COG2212	antiporter activity
CFK37_13665	COG0651	ATP synthesis coupled electron transport
CFK37_13670	COG1006	Multisubunit Na H antiporter MnhC subunit
CFK37_13675	COG2111	Na H antiporter
CFK37_13675	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CFK37_13685	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
CFK37_13690	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
CFK37_13695	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CFK37_13700	COG1534	Rna-binding protein
CFK37_13705	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CFK37_13710	COG1713	HD superfamily hydrolase involved in NAD metabolism
CFK37_13715	COG0799	negative regulation of ribosome biogenesis
CFK37_13720	COG2226	methyltransferase
CFK37_13725	COG1596	polysaccharide export
CFK37_13725	COG1555	photosystem II stabilization
CFK37_13730	COG2131	deaminase
CFK37_13735	COG2333	competence protein COMEC
CFK37_13735	COG0658	competence protein
CFK37_13745	COG1466	dna polymerase III delta subunit
CFK37_13750	COG0268	Binds directly to 16S ribosomal RNA
CFK37_13755	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
CFK37_13760	COG0860	N-Acetylmuramoyl-L-alanine amidase
CFK37_13770	COG0481	GTPase activity
CFK37_13775	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CFK37_13780	COG1420	regulation of RNA biosynthetic process
CFK37_13785	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CFK37_13790	COG0443	Heat shock 70 kDa protein
CFK37_13795	COG0484	heat shock protein binding
CFK37_13800	COG2264	protein methyltransferase activity
CFK37_13805	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CFK37_13810	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CFK37_13815	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CFK37_13820	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CFK37_13825	COG1610	YqeY-like protein
CFK37_13830	COG1030	water channel activity
CFK37_13835	COG4864	UPF0365 protein
CFK37_13855	COG1702	phosphate starvation-inducible protein PhoH
CFK37_13860	COG1480	7TM receptor with intracellular HD hydrolase
CFK37_13865	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CFK37_13875	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CFK37_13885	COG1381	Involved in DNA repair and RecF pathway recombination
CFK37_13890	COG0752	glycyl-tRNA synthetase alpha subunit
CFK37_13895	COG0751	glycine-tRNA ligase activity
CFK37_13900	COG0517	IMP dehydrogenase activity
CFK37_13905	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
CFK37_13910	COG0358	DNA primase activity
CFK37_13915	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CFK37_13925	COG2384	SAM-dependent methyltransferase
CFK37_13930	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CFK37_13940	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
CFK37_13955	COG4709	membrane
CFK37_13970	COG0704	Plays a role in the regulation of phosphate uptake
CFK37_14005	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CFK37_14010	COG0477	Major facilitator Superfamily
CFK37_14020	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CFK37_14025	COG0573	inorganic phosphate transmembrane transporter activity
CFK37_14030	COG0581	inorganic phosphate transmembrane transporter activity
CFK37_14035	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CFK37_14040	COG0704	Plays a role in the regulation of phosphate uptake
CFK37_14055	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CFK37_14060	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CFK37_14065	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CFK37_14075	COG0705	Rhomboid family
CFK37_14075	COG0457	Tetratricopeptide repeat
CFK37_14085	COG0697	spore germination
CFK37_14095	COG1940	carbohydrate kinase activity
CFK37_14100	COG1368	sulfuric ester hydrolase activity
CFK37_14110	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CFK37_14140	COG4537	Required for transformation and DNA binding
CFK37_14145	COG1459	type II secretion system
CFK37_14150	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CFK37_14170	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CFK37_14175	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CFK37_14180	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CFK37_14185	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CFK37_14190	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CFK37_14195	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CFK37_14200	COG1012	belongs to the aldehyde dehydrogenase family
CFK37_14205	COG1321	iron dependent repressor
CFK37_14210	COG1752	Esterase of the alpha-beta hydrolase superfamily
CFK37_14230	COG0006	proline dipeptidase activity
CFK37_14235	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CFK37_14245	COG3854	ATPases associated with a variety of cellular activities
CFK37_14295	COG0511	ligase activity, forming carbon-carbon bonds
CFK37_14300	COG0439	Biotin carboxylase
CFK37_14305	COG1302	Protein conserved in bacteria
CFK37_14310	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CFK37_14315	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CFK37_14320	COG1570	exodeoxyribonuclease VII activity
CFK37_14325	COG1722	exodeoxyribonuclease VII activity
CFK37_14340	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
CFK37_14345	COG1438	arginine binding
CFK37_14350	COG0497	DNA recombination
CFK37_14355	COG0750	zinc metalloprotease
CFK37_14375	COG3290	protein histidine kinase activity
CFK37_14375	COG3829	transcription factor binding
CFK37_14380	COG0280	phosphate acetyltransferase
CFK37_14395	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CFK37_14400	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CFK37_14405	COG0022	dehydrogenase e1 component
CFK37_14410	COG0508	dehydrogenase complex catalyzes the overall conversion of
CFK37_14420	COG4129	membrane
CFK37_14435	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CFK37_14440	COG2195	Cleaves the N-terminal amino acid of tripeptides
CFK37_14445	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CFK37_14450	COG1028	Short-chain dehydrogenase reductase Sdr
CFK37_14455	COG0318	PFAM AMP-dependent synthetase and ligase
CFK37_14460	COG4166	transmembrane transport
CFK37_14465	COG1012	belongs to the aldehyde dehydrogenase family
CFK37_14470	COG1234	tRNA 3'-trailer cleavage
CFK37_14475	COG1902	pentaerythritol trinitrate reductase activity
CFK37_14480	COG0584	glycerophosphoryl diester phosphodiesterase
CFK37_14485	COG4187	Peptidase family M20/M25/M40
CFK37_14490	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CFK37_14495	COG0300	oxidoreductase activity
CFK37_14505	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CFK37_14510	COG0667	Aldo Keto reductase
CFK37_14520	COG1379	DNA repair
CFK37_14525	COG1300	Membrane
CFK37_14530	COG0735	belongs to the Fur family
CFK37_14540	COG4974	Belongs to the 'phage' integrase family
CFK37_14545	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
CFK37_14560	COG1686	Belongs to the peptidase S11 family
CFK37_14570	COG2172	sigma factor antagonist activity
CFK37_14590	COG0697	spore germination
CFK37_14595	COG0019	diaminopimelate decarboxylase activity
CFK37_14600	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CFK37_14605	COG0456	acetyltransferase
CFK37_14615	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
CFK37_14620	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CFK37_14625	COG1686	Belongs to the peptidase S11 family
CFK37_14630	COG2715	membrane protein required for spore maturation
CFK37_14635	COG0700	Nucleoside recognition
CFK37_14640	COG1187	pseudouridine synthase activity
CFK37_14645	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CFK37_14650	COG1333	cytochrome c biogenesis protein
CFK37_14655	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CFK37_14660	COG0745	RESPONSE REGULATOR receiver
CFK37_14665	COG5002	protein histidine kinase activity
CFK37_14680	COG1141	Ferredoxin
CFK37_14690	COG0514	ATP-dependent DNA helicase (RecQ)
CFK37_14695	COG1266	CAAX protease self-immunity
CFK37_14705	COG3546	catalase activity
CFK37_14720	COG1408	metallophosphoesterase
CFK37_14725	COG4862	establishment of competence for transformation
CFK37_14730	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CFK37_14735	COG0492	ferredoxin-NADP+ reductase activity
CFK37_14745	COG2339	peptidase activity
CFK37_14750	COG3773	Cell wall hydrolase
CFK37_14750	COG3409	Peptidoglycan-binding domain 1 protein
CFK37_14755	COG2959	enzyme of heme biosynthesis
CFK37_14760	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CFK37_14765	COG0539	negative regulation of cytoplasmic translation
CFK37_14775	COG1160	GTP binding
CFK37_14780	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CFK37_14800	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
CFK37_14805	COG0776	regulation of translation
CFK37_14815	COG0142	geranyltranstransferase activity
CFK37_14820	COG2226	methyltransferase
CFK37_14825	COG0142	geranyltranstransferase activity
CFK37_14830	COG0105	UTP biosynthetic process
CFK37_14835	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CFK37_14840	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CFK37_14845	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CFK37_14850	COG0457	Tetratricopeptide repeat
CFK37_14855	COG5582	Belongs to the UPF0302 family
CFK37_14870	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CFK37_14880	COG4347	Protein of unknown function (DUF1405)
CFK37_14890	COG2738	Putative neutral zinc metallopeptidase
CFK37_14895	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CFK37_14900	COG1694	Mazg nucleotide pyrophosphohydrolase
CFK37_14905	COG1803	Methylglyoxal synthase
CFK37_14910	COG0438	transferase activity, transferring glycosyl groups
CFK37_14915	COG0617	tRNA 3'-terminal CCA addition
CFK37_14935	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
CFK37_14940	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CFK37_14940	COG1199	ATP-dependent helicase activity
CFK37_14955	COG0436	Aminotransferase
CFK37_14960	COG0017	Asparaginyl-tRNA synthetase
CFK37_14965	COG3935	DnaD domain protein
CFK37_14970	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CFK37_14975	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CFK37_14975	COG4499	WXG100 protein secretion system (Wss), protein YukC
CFK37_14980	COG3331	DNA recombination
CFK37_15000	COG0295	cytidine deaminase activity
CFK37_15005	COG3599	regulation of cell shape
CFK37_15015	COG0116	Belongs to the methyltransferase superfamily
CFK37_15020	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
CFK37_15025	COG3424	synthase
CFK37_15030	COG1755	Isoprenylcysteine carboxyl methyltransferase
CFK37_15035	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
CFK37_15050	COG1418	mRNA catabolic process
CFK37_15060	COG1289	transmembrane transporter activity
CFK37_15065	COG3584	3D domain protein
CFK37_15080	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
CFK37_15085	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CFK37_15090	COG0746	molybdenum cofactor guanylyltransferase activity
CFK37_15095	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CFK37_15100	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CFK37_15105	COG0805	protein transport
CFK37_15110	COG4479	Belongs to the UPF0346 family
CFK37_15115	COG0420	3'-5' exonuclease activity
CFK37_15120	COG0419	ATPase involved in DNA repair
CFK37_15130	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CFK37_15130	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CFK37_15140	COG2062	phosphohistidine phosphatase, SixA
CFK37_15155	COG1254	Belongs to the acylphosphatase family
CFK37_15160	COG3191	aminopeptidase activity
CFK37_15165	COG3584	3D domain protein
CFK37_15165	COG1388	LysM domain
CFK37_15170	COG0583	DNA-binding transcription factor activity
CFK37_15180	COG0372	Belongs to the citrate synthase family
CFK37_15190	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
CFK37_15195	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CFK37_15200	COG2323	membrane
CFK37_15220	COG0390	transport system, permease component
CFK37_15240	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CFK37_15245	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
CFK37_15250	COG0516	GMP reductase activity
CFK37_15250	COG0517	IMP dehydrogenase activity
CFK37_15255	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CFK37_15260	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CFK37_15265	COG1024	Enoyl-CoA hydratase
CFK37_15270	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CFK37_15275	COG0511	ligase activity, forming carbon-carbon bonds
CFK37_15280	COG0439	Biotin carboxylase
CFK37_15285	COG0318	PFAM AMP-dependent synthetase and ligase
CFK37_15290	COG1960	acyl-CoA dehydrogenase activity
CFK37_15305	COG0187	DNA topoisomerase II activity
CFK37_15310	COG1832	CoA-binding protein
CFK37_15320	COG1125	glycine betaine transport
CFK37_15320	COG0517	IMP dehydrogenase activity
CFK37_15325	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CFK37_15330	COG1469	GTP cyclohydrolase I activity
CFK37_15335	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CFK37_15345	COG0824	Thioesterase
CFK37_15355	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CFK37_15360	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CFK37_15365	COG4191	Histidine kinase
CFK37_15375	COG4846	Membrane protein involved in cytochrome C biogenesis
CFK37_15380	COG2111	Na H antiporter
CFK37_15385	COG0785	Cytochrome C biogenesis protein
CFK37_15390	COG3763	UPF0154 protein
CFK37_15405	COG4224	UPF0291 protein
CFK37_15410	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CFK37_15415	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CFK37_15420	COG0174	glutamine synthetase
CFK37_15425	COG0789	Transcriptional regulator
CFK37_15430	COG3344	reverse transcriptase
CFK37_15435	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
CFK37_15440	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CFK37_15445	COG0464	growth
CFK37_15450	COG1923	regulation of RNA biosynthetic process
CFK37_15455	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CFK37_15460	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CFK37_15465	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CFK37_15475	COG4550	Control of competence regulator ComK, YlbF/YmcA
CFK37_15480	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CFK37_15485	COG2359	stage V sporulation protein S
CFK37_15490	COG1692	metallophosphoesterase
CFK37_15495	COG1418	mRNA catabolic process
CFK37_15500	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CFK37_15505	COG1546	Belongs to the CinA family
CFK37_15505	COG1058	Belongs to the CinA family
CFK37_15510	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CFK37_15515	COG1426	Protein conserved in bacteria
CFK37_15530	COG0300	oxidoreductase activity
CFK37_15535	COG0612	Peptidase, M16
CFK37_15540	COG0612	Peptidase, M16
CFK37_15565	COG2188	Transcriptional regulator
CFK37_15570	COG1674	ftsk spoiiie
CFK37_15580	COG0740	serine-type endopeptidase activity
CFK37_15585	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CFK37_15590	COG0527	aspartate kinase activity
CFK37_15595	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CFK37_15600	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CFK37_15605	COG1873	PFAM PRC-barrel domain
CFK37_15610	COG0612	Peptidase, M16
CFK37_15615	COG0726	polysaccharide deacetylase
CFK37_15620	COG1185	polyribonucleotide nucleotidyltransferase activity
CFK37_15625	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CFK37_15630	COG0196	riboflavin kinase activity
CFK37_15635	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CFK37_15640	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CFK37_15650	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CFK37_15660	COG2740	Nucleic-acid-binding protein implicated in transcription termination
CFK37_15665	COG0195	Participates in both transcription termination and antitermination
CFK37_15670	COG0779	Required for maturation of 30S ribosomal subunits
CFK37_15675	COG2176	DNA-directed DNA polymerase activity
CFK37_15680	COG0750	zinc metalloprotease
CFK37_15685	COG4589	Belongs to the CDS family
CFK37_15690	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CFK37_15695	COG0233	cytoplasmic translational termination
CFK37_15700	COG0528	UMP kinase activity
CFK37_15705	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CFK37_15710	COG0052	Belongs to the universal ribosomal protein uS2 family
CFK37_15715	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
CFK37_15720	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
CFK37_15725	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
CFK37_15730	COG4974	Belongs to the 'phage' integrase family
CFK37_15740	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CFK37_15745	COG0758	DNA mediated transformation
CFK37_15750	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CFK37_15755	COG0045	succinate-CoA ligase (ADP-forming) activity
CFK37_15760	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CFK37_15775	COG0335	large ribosomal subunit rRNA binding
CFK37_15780	COG0336	Belongs to the RNA methyltransferase TrmD family
CFK37_15795	COG1837	Belongs to the UPF0109 family
CFK37_15800	COG0228	four-way junction DNA binding
CFK37_15805	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CFK37_15810	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
CFK37_15815	COG0552	protein localization to endoplasmic reticulum
CFK37_15820	COG1196	nuclear chromosome segregation
CFK37_15825	COG4840	Belongs to the UPF0435 family
CFK37_15830	COG0571	ribonuclease III activity
CFK37_15835	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CFK37_15840	COG1028	Short-chain dehydrogenase reductase Sdr
CFK37_15845	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CFK37_15850	COG0416	fatty acid biosynthetic process
CFK37_15855	COG1349	DNA-binding transcription factor activity
CFK37_15860	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CFK37_15865	COG1760	l-serine dehydratase
CFK37_15885	COG0681	Belongs to the peptidase S26 family
CFK37_15890	COG1404	Belongs to the peptidase S8 family
CFK37_15915	COG1607	acyl-coa hydrolase
CFK37_15920	COG2323	membrane
CFK37_15930	COG1461	Dihydroxyacetone kinase
CFK37_15935	COG1302	Protein conserved in bacteria
CFK37_15940	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CFK37_15950	COG1564	THIamine pyrophosphokinase
CFK37_15955	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CFK37_15960	COG1162	GTPase activity
CFK37_15965	COG2815	serine threonine protein kinase
CFK37_15965	COG0515	serine threonine protein kinase
CFK37_15970	COG0631	protein serine/threonine phosphatase activity
CFK37_15975	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CFK37_15975	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CFK37_15980	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CFK37_15985	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CFK37_15990	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CFK37_15995	COG1758	RNA polymerase activity
CFK37_16000	COG0194	GDP metabolic process
CFK37_16005	COG2052	Domain of unknown function (DUF370)
CFK37_16010	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CFK37_16020	COG1764	response to oxidative stress
CFK37_16025	COG0583	DNA-binding transcription factor activity
CFK37_16030	COG2226	methyltransferase
CFK37_16035	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CFK37_16040	COG0284	orotidine-5'-phosphate decarboxylase activity
CFK37_16045	COG0167	dihydroorotate dehydrogenase activity
CFK37_16050	COG0543	2 iron, 2 sulfur cluster binding
CFK37_16055	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CFK37_16060	COG0505	Belongs to the CarA family
CFK37_16065	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CFK37_16070	COG0540	Belongs to the ATCase OTCase family
CFK37_16075	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
CFK37_16080	COG0564	pseudouridine synthase activity
CFK37_16085	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CFK37_16090	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CFK37_16095	COG3599	regulation of cell shape
CFK37_16105	COG0762	integral membrane protein
CFK37_16110	COG1799	cell septum assembly
CFK37_16115	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CFK37_16125	COG1873	PFAM PRC-barrel domain
CFK37_16130	COG1191	sigma factor activity
CFK37_16135	COG1191	sigma factor activity
CFK37_16145	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CFK37_16150	COG0849	cell division
CFK37_16155	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CFK37_16160	COG0772	Belongs to the SEDS family
CFK37_16165	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CFK37_16170	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CFK37_16175	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CFK37_16180	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CFK37_16185	COG0768	penicillin binding
CFK37_16200	COG0275	rRNA processing
CFK37_16205	COG2001	Belongs to the MraZ family
CFK37_16210	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
CFK37_16220	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CFK37_16225	COG0454	-acetyltransferase
CFK37_16235	COG1024	Enoyl-CoA hydratase
CFK37_16240	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CFK37_16245	COG1399	metal-binding, possibly nucleic acid-binding protein
CFK37_16250	COG1323	Belongs to the UPF0348 family
CFK37_16255	COG3480	Lon protease (S16) C-terminal proteolytic domain
CFK37_16260	COG3314	Sporulation integral membrane protein YlbJ
CFK37_16265	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CFK37_16270	COG0742	ribosomal rna small subunit methyltransferase
CFK37_16275	COG4471	UPF0298 protein
CFK37_16280	COG3679	Belongs to the UPF0342 family
CFK37_16295	COG2340	Cysteine-rich secretory protein family
CFK37_16315	COG3336	cytochrome c oxidase
CFK37_16335	COG2010	Cytochrome c
CFK37_16335	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CFK37_16340	COG0109	protoheme IX farnesyltransferase activity
CFK37_16345	COG1612	heme a metabolic process
CFK37_16350	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
CFK37_16355	COG0772	Belongs to the SEDS family
CFK37_16360	COG4838	Belongs to the UPF0358 family
CFK37_16365	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CFK37_16380	COG4896	Protein conserved in bacteria
CFK37_16395	COG0483	inositol monophosphate 1-phosphatase activity
CFK37_16405	COG4493	Belongs to the UPF0637 family
CFK37_16410	COG4476	Belongs to the UPF0223 family
CFK37_16420	COG1982	Orn Lys Arg decarboxylase major
CFK37_16430	COG0726	polysaccharide deacetylase
CFK37_16435	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CFK37_16445	COG0508	dehydrogenase complex catalyzes the overall conversion of
CFK37_16450	COG0022	dehydrogenase e1 component
CFK37_16465	COG0242	peptide deformylase activity
CFK37_16475	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CFK37_16485	COG0028	Belongs to the TPP enzyme family
CFK37_16490	COG0569	domain protein
CFK37_16495	COG1132	(ABC) transporter
CFK37_16500	COG1132	(ABC) transporter
CFK37_16505	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CFK37_16510	COG0450	alkyl hydroperoxide reductase
CFK37_16515	COG0668	transmembrane transport
CFK37_16525	COG2814	Major facilitator Superfamily
CFK37_16530	COG0517	IMP dehydrogenase activity
CFK37_16535	COG1272	protein, Hemolysin III
CFK37_16540	COG1028	Short-chain dehydrogenase reductase Sdr
CFK37_16545	COG1408	metallophosphoesterase
CFK37_16550	COG1999	signal sequence binding
CFK37_16585	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CFK37_16590	COG5001	Diguanylate cyclase
CFK37_16590	COG3300	MHYT domain
CFK37_16600	COG3835	regulator
CFK37_16615	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CFK37_16620	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CFK37_16630	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CFK37_16635	COG0303	'Molybdopterin
CFK37_16665	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CFK37_16680	COG2323	membrane
CFK37_16685	COG0697	spore germination
CFK37_16700	COG2323	membrane
CFK37_16705	COG0604	alcohol dehydrogenase
CFK37_16720	COG1966	Carbon starvation protein
CFK37_16725	COG2427	Protein of unknown function (DUF1641)
CFK37_16730	COG3383	formate dehydrogenase (NAD+) activity
CFK37_16735	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CFK37_16745	COG3069	C4-dicarboxylate transmembrane transporter activity
CFK37_16750	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CFK37_16760	COG3859	Proton-coupled thiamine transporter YuaJ
CFK37_16775	COG4637	Psort location Cytoplasmic, score
CFK37_16780	COG2353	YceI-like domain
CFK37_16785	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CFK37_16805	COG1252	NADH dehydrogenase
CFK37_16820	COG0318	PFAM AMP-dependent synthetase and ligase
CFK37_16830	COG1331	Highly conserved protein containing a thioredoxin domain
CFK37_16840	COG1408	metallophosphoesterase
CFK37_16850	COG1132	(ABC) transporter
CFK37_16870	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
CFK37_16875	COG0367	asparagine synthase
CFK37_16885	COG1132	(ABC) transporter
CFK37_16890	COG1216	Glycosyl transferase, family 2
CFK37_16905	COG0438	transferase activity, transferring glycosyl groups
CFK37_16910	COG1216	Glycosyl transferase, family 2
CFK37_16910	COG1442	glycosyl transferase family 8
CFK37_16930	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CFK37_16935	COG0110	maltose O-acetyltransferase activity
CFK37_16940	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CFK37_16945	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CFK37_16955	COG0463	Glycosyl transferase, family 2
CFK37_16960	COG0438	transferase activity, transferring glycosyl groups
CFK37_16965	COG0438	transferase activity, transferring glycosyl groups
CFK37_16970	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CFK37_16975	COG1086	Polysaccharide biosynthesis protein
CFK37_16980	COG0489	protein tyrosine kinase activity
CFK37_17000	COG1231	oxidoreductase activity
CFK37_17010	COG0077	Prephenate dehydratase
CFK37_17020	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CFK37_17040	COG2027	D-alanyl-D-alanine carboxypeptidase
CFK37_17045	COG0477	Major facilitator Superfamily
CFK37_17060	COG0456	acetyltransferase
CFK37_17095	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CFK37_17100	COG0066	3-isopropylmalate dehydratase activity
CFK37_17105	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CFK37_17110	COG0473	3-isopropylmalate dehydrogenase activity
CFK37_17115	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CFK37_17120	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CFK37_17125	COG0440	acetolactate synthase activity
CFK37_17130	COG0028	Belongs to the TPP enzyme family
CFK37_17135	COG0083	homoserine kinase activity
CFK37_17140	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CFK37_17145	COG0460	homoserine dehydrogenase
CFK37_17150	COG0527	aspartate kinase activity
CFK37_17160	COG0129	dihydroxy-acid dehydratase activity
CFK37_17170	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CFK37_17180	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CFK37_17215	COG1346	cytolysis
CFK37_17220	COG1380	Effector of murein hydrolase LrgA
CFK37_17225	COG0583	DNA-binding transcription factor activity
CFK37_17295	COG2515	1-aminocyclopropane-1-carboxylate deaminase
CFK37_17310	COG0402	S-adenosylhomocysteine deaminase activity
CFK37_17325	COG0385	Bile acid
CFK37_17330	COG0287	Prephenate dehydrogenase
CFK37_17335	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CFK37_17340	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
CFK37_17340	COG1605	Chorismate mutase
CFK37_17345	COG0436	Aminotransferase
CFK37_17350	COG0527	aspartate kinase activity
CFK37_17355	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CFK37_17360	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CFK37_17365	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CFK37_17375	COG1473	amidohydrolase
CFK37_17380	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CFK37_17405	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CFK37_17410	COG3540	Alkaline phosphatase
CFK37_17425	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CFK37_17445	COG0789	Transcriptional regulator
CFK37_17450	COG1253	flavin adenine dinucleotide binding
CFK37_17455	COG0706	membrane insertase activity
CFK37_17470	COG2226	methyltransferase
CFK37_17485	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CFK37_17490	COG0640	Transcriptional regulator
CFK37_17495	COG0493	'glutamate synthase
CFK37_17500	COG0070	glutamate synthase
CFK37_17500	COG0069	glutamate synthase activity
CFK37_17500	COG0067	glutamate synthase
CFK37_17505	COG0583	DNA-binding transcription factor activity
CFK37_17515	COG0431	NADPH-dependent FMN reductase
CFK37_17520	COG1917	Cupin 2, conserved barrel domain protein
CFK37_17535	COG3192	ethanolamine utilization protein
CFK37_17540	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CFK37_17545	COG2233	PERMEase
CFK37_17550	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CFK37_17555	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CFK37_17560	COG1845	cytochrome c oxidase, subunit III
CFK37_17580	COG0737	Belongs to the 5'-nucleotidase family
CFK37_17625	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CFK37_17640	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CFK37_17650	COG1609	Transcriptional regulator
CFK37_17660	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CFK37_17675	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
CFK37_17690	COG0477	Major facilitator Superfamily
CFK37_17695	COG1113	amino acid transport
CFK37_17705	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CFK37_17740	COG3876	Protein conserved in bacteria
CFK37_17745	COG1447	Phosphotransferase system cellobiose-specific component IIA
CFK37_17750	COG3394	polysaccharide catabolic process
CFK37_17755	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CFK37_17765	COG1486	melibiose metabolic process
CFK37_17770	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CFK37_17770	COG3711	transcriptional antiterminator
CFK37_17780	COG0589	response to stress
CFK37_17785	COG0477	Major facilitator Superfamily
CFK37_17845	COG4372	Transposase
CFK37_17915	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CFK37_17920	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CFK37_17925	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CFK37_17930	COG1268	BioY protein
CFK37_17935	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CFK37_17980	COG1131	(ABC) transporter
CFK37_18000	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CFK37_18005	COG2022	thiamine diphosphate biosynthetic process
CFK37_18010	COG2104	thiamine diphosphate biosynthetic process
CFK37_18015	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CFK37_18020	COG0352	thiamine-phosphate diphosphorylase activity
CFK37_18030	COG3227	Zinc metalloprotease (Elastase)
CFK37_18040	COG0681	Belongs to the peptidase S26 family
CFK37_18050	COG0662	Cupin 2, conserved barrel domain protein
CFK37_18055	COG1494	fructose-1,6-bisphosphatase
CFK37_18060	COG0698	ribose 5-phosphate isomerase
CFK37_18070	COG2376	Dihydroxyacetone kinase
CFK37_18075	COG2814	Major facilitator Superfamily
CFK37_18080	COG1063	alcohol dehydrogenase
CFK37_18085	COG1349	DNA-binding transcription factor activity
CFK37_18090	COG4166	transmembrane transport
CFK37_18125	COG2851	Citrate transporter
CFK37_18130	COG3829	transcription factor binding
CFK37_18130	COG3290	protein histidine kinase activity
CFK37_18140	COG0583	DNA-binding transcription factor activity
CFK37_18150	COG0346	lactoylglutathione lyase activity
CFK37_18155	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CFK37_18160	COG0431	NADPH-dependent FMN reductase
CFK37_18205	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CFK37_18210	COG1335	isochorismatase
CFK37_18215	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CFK37_18240	COG3773	Cell wall hydrolase
CFK37_18270	COG0456	acetyltransferase
CFK37_18280	COG2226	methyltransferase
CFK37_18310	COG0697	spore germination
CFK37_18320	COG1309	transcriptional regulator
CFK37_18325	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
CFK37_18345	COG3739	integral membrane protein
CFK37_18350	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CFK37_18355	COG3655	Transcriptional regulator
CFK37_18380	COG0456	acetyltransferase
CFK37_18395	COG3011	Protein conserved in bacteria
CFK37_18410	COG1619	proteins homologs of microcin C7 resistance protein MccF
CFK37_18415	COG2268	Band 7 protein
CFK37_18425	COG2814	Major facilitator Superfamily
CFK37_18435	COG1472	Belongs to the glycosyl hydrolase 3 family
CFK37_18450	COG0563	adenylate kinase activity
CFK37_18480	COG0517	IMP dehydrogenase activity
CFK37_18480	COG4175	Glycine betaine
CFK37_18485	COG4176	ABC-type proline glycine betaine transport system permease component
CFK37_18510	COG1476	TRANSCRIPTIONal
CFK37_18525	COG1231	oxidoreductase activity
CFK37_18530	COG1028	Short-chain dehydrogenase reductase Sdr
CFK37_18535	COG1028	Short-chain dehydrogenase reductase Sdr
CFK37_18560	COG1141	Ferredoxin
CFK37_18580	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
CFK37_18615	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
CFK37_18620	COG2318	DinB family
CFK37_18635	COG1247	-acetyltransferase
CFK37_18645	COG5504	Zn-dependent protease
CFK37_18660	COG5002	protein histidine kinase activity
CFK37_18665	COG0745	RESPONSE REGULATOR receiver
CFK37_18670	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CFK37_18675	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CFK37_18680	COG0785	Cytochrome C biogenesis protein
CFK37_18690	COG0740	serine-type endopeptidase activity
CFK37_18710	COG0622	Phosphoesterase
CFK37_18715	COG3425	synthase
CFK37_18725	COG0714	Associated with various cellular activities
CFK37_18730	COG4548	von Willebrand factor, type A
CFK37_18755	COG1349	DNA-binding transcription factor activity
CFK37_18760	COG3336	cytochrome c oxidase
CFK37_18765	COG2217	Heavy metal translocating P-type atpase
CFK37_18775	COG0527	aspartate kinase activity
CFK37_18800	COG0076	glutamate decarboxylase activity
CFK37_18815	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CFK37_18825	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
CFK37_18825	COG2199	diguanylate cyclase activity
CFK37_18855	COG0842	Transport permease protein
CFK37_18860	COG1131	(ABC) transporter
CFK37_18880	COG1301	dicarboxylic acid transport
CFK37_18885	COG1929	Belongs to the glycerate kinase type-1 family
CFK37_18890	COG1388	LysM domain
CFK37_18890	COG3858	chitin binding
CFK37_18895	COG0535	radical SAM domain protein
CFK37_18905	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CFK37_18915	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CFK37_18950	COG1595	DNA-templated transcription, initiation
CFK37_19005	COG0494	nUDIX hydrolase
CFK37_19025	COG1619	proteins homologs of microcin C7 resistance protein MccF
CFK37_19030	COG0456	acetyltransferase
CFK37_19030	COG0454	-acetyltransferase
CFK37_19070	COG0456	acetyltransferase
CFK37_19070	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
CFK37_19080	COG0693	protein deglycase activity
CFK37_19115	COG2814	Major facilitator Superfamily
CFK37_19120	COG0367	asparagine synthase
CFK37_19130	COG0702	epimerase
CFK37_19135	COG0626	cystathionine gamma-synthase activity
CFK37_19145	COG1073	alpha beta
CFK37_19155	COG1136	(ABC) transporter
CFK37_19165	COG5002	protein histidine kinase activity
CFK37_19185	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CFK37_19200	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
CFK37_19220	COG0640	Transcriptional regulator
CFK37_19240	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CFK37_19245	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CFK37_19250	COG0640	Transcriptional regulator
CFK37_19255	COG3339	Conserved Protein
CFK37_19265	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
CFK37_19270	COG0405	Gamma-glutamyltransferase
CFK37_19275	COG2322	membrane
CFK37_19280	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
CFK37_19295	COG2318	DinB family
CFK37_19305	COG0673	inositol 2-dehydrogenase activity
CFK37_19310	COG2271	Major facilitator Superfamily
CFK37_19325	COG1309	transcriptional regulator
CFK37_19355	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CFK37_19460	COG1619	proteins homologs of microcin C7 resistance protein MccF
CFK37_19485	COG0702	epimerase
CFK37_19525	COG0577	efflux transmembrane transporter activity
CFK37_19530	COG1136	(ABC) transporter
CFK37_19535	COG2205	protein histidine kinase activity
CFK37_19540	COG0745	RESPONSE REGULATOR receiver
CFK37_19555	COG0640	Transcriptional regulator
CFK37_19560	COG0477	Major facilitator Superfamily
CFK37_19570	COG0667	Aldo Keto reductase
CFK37_19580	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
CFK37_19585	COG1131	(ABC) transporter
CFK37_19605	COG1595	DNA-templated transcription, initiation
CFK37_19610	COG1028	Short-chain dehydrogenase reductase Sdr
CFK37_19620	COG0745	RESPONSE REGULATOR receiver
CFK37_19635	COG2205	protein histidine kinase activity
CFK37_19660	COG0305	Participates in initiation and elongation during chromosome replication
CFK37_19685	COG0069	glutamate synthase activity
CFK37_19720	COG4372	Transposase
CFK37_19735	COG4372	Transposase
CFK37_19760	COG0210	DNA helicase
CFK37_19800	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CFK37_19820	COG0653	protein targeting
CFK37_19825	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid