locus-tag	class	description
GWK91_00005	COG3383	formate dehydrogenase (NAD+) activity
GWK91_00010	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GWK91_00015	COG0702	epimerase
GWK91_00020	COG1192	Involved in chromosome partitioning
GWK91_00060	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
GWK91_00065	COG1140	nitrate reductase beta subunit
GWK91_00075	COG2181	nitrate reductase activity
GWK91_00080	COG0431	NADPH-dependent FMN reductase
GWK91_00085	COG0662	Cupin 2, conserved barrel domain protein
GWK91_00100	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GWK91_00100	COG1263	PTS System
GWK91_00105	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
GWK91_00110	COG1737	Transcriptional regulator
GWK91_00155	COG1131	(ABC) transporter
GWK91_00165	COG0477	Major facilitator Superfamily
GWK91_00170	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
GWK91_00175	COG3853	Toxic anion resistance protein (TelA)
GWK91_00185	COG1473	amidohydrolase
GWK91_00195	COG3639	organic phosphonate transmembrane transporter activity
GWK91_00200	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
GWK91_00205	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
GWK91_00210	COG0583	DNA-binding transcription factor activity
GWK91_00225	COG1473	amidohydrolase
GWK91_00270	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
GWK91_00275	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GWK91_00280	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GWK91_00285	COG0492	ferredoxin-NADP+ reductase activity
GWK91_00290	COG0300	oxidoreductase activity
GWK91_00295	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
GWK91_00305	COG0196	riboflavin kinase activity
GWK91_00325	COG3655	Transcriptional regulator
GWK91_00335	COG1082	Xylose isomerase domain protein TIM barrel
GWK91_00340	COG0322	excinuclease ABC activity
GWK91_00370	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GWK91_00375	COG0745	RESPONSE REGULATOR receiver
GWK91_00380	COG2205	protein histidine kinase activity
GWK91_00390	COG0367	asparagine synthase
GWK91_00400	COG5001	Diguanylate cyclase
GWK91_00400	COG3300	MHYT domain
GWK91_00425	COG1575	Belongs to the MenA family. Type 1 subfamily
GWK91_00440	COG1028	Short-chain dehydrogenase reductase Sdr
GWK91_00445	COG0318	PFAM AMP-dependent synthetase and ligase
GWK91_00460	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
GWK91_00465	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GWK91_00475	COG1131	(ABC) transporter
GWK91_00480	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
GWK91_00505	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GWK91_00520	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
GWK91_00525	COG0346	lactoylglutathione lyase activity
GWK91_00530	COG0400	carboxylic ester hydrolase activity
GWK91_00535	COG0655	NAD(P)H dehydrogenase (quinone) activity
GWK91_00540	COG2766	serine protein kinase
GWK91_00545	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GWK91_00550	COG0765	amino acid transport
GWK91_00555	COG1126	abc transporter atp-binding protein
GWK91_00565	COG0640	Transcriptional regulator
GWK91_00570	COG0567	Dehydrogenase, E1 component
GWK91_00575	COG0508	dehydrogenase complex catalyzes the overall conversion of
GWK91_00580	COG2718	Belongs to the UPF0229 family
GWK91_00590	COG2340	Cysteine-rich secretory protein family
GWK91_00595	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GWK91_00600	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GWK91_00610	COG0656	L-ascorbic acid biosynthetic process
GWK91_00615	COG0288	reversible hydration of carbon dioxide
GWK91_00625	COG4841	protein insertion into membrane
GWK91_00630	COG1132	(ABC) transporter
GWK91_00635	COG1132	(ABC) transporter
GWK91_00640	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GWK91_00645	COG1191	sigma factor activity
GWK91_00670	COG1131	(ABC) transporter
GWK91_00675	COG4221	oxidoreductase activity
GWK91_00690	COG2719	SpoVR family
GWK91_00700	COG1686	Belongs to the peptidase S11 family
GWK91_00710	COG0659	secondary active sulfate transmembrane transporter activity
GWK91_00715	COG2340	Cysteine-rich secretory protein family
GWK91_00725	COG1253	flavin adenine dinucleotide binding
GWK91_00730	COG2827	Endonuclease containing a URI domain
GWK91_00740	COG0351	phosphomethylpyrimidine kinase
GWK91_00745	COG1733	regulation of RNA biosynthetic process
GWK91_00780	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GWK91_00800	COG1247	-acetyltransferase
GWK91_00805	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
GWK91_00815	COG0840	transmembrane signaling receptor activity
GWK91_00815	COG5278	phosphoserine phosphatase activity
GWK91_00825	COG2270	Major facilitator Superfamily
GWK91_00835	COG0114	fumarate hydratase activity
GWK91_00860	COG3679	Belongs to the UPF0342 family
GWK91_00870	COG4152	abc transporter atp-binding protein
GWK91_00875	COG1668	transmembrane transport
GWK91_00885	COG0420	3'-5' exonuclease activity
GWK91_00890	COG1196	nuclear chromosome segregation
GWK91_00895	COG1510	regulation of RNA biosynthetic process
GWK91_00900	COG3481	metal-dependent phosphohydrolase, HD sub domain
GWK91_00910	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GWK91_00930	COG1846	Transcriptional regulator
GWK91_00965	COG0517	IMP dehydrogenase activity
GWK91_00965	COG4175	Glycine betaine
GWK91_00975	COG2113	Glycine betaine
GWK91_00990	COG0537	adenosine 5'-monophosphoramidase activity
GWK91_00995	COG1131	(ABC) transporter
GWK91_01000	COG4473	ABC transporter
GWK91_01010	COG1473	amidohydrolase
GWK91_01020	COG4585	Histidine kinase
GWK91_01025	COG2197	response regulator
GWK91_01030	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
GWK91_01040	COG2329	Antibiotic biosynthesis monooxygenase
GWK91_01045	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GWK91_01050	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
GWK91_01070	COG1234	tRNA 3'-trailer cleavage
GWK91_01075	COG0095	Lipoate-protein ligase
GWK91_01080	COG0318	PFAM AMP-dependent synthetase and ligase
GWK91_01095	COG1116	anion transmembrane transporter activity
GWK91_01095	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GWK91_01115	COG0398	Pfam SNARE associated Golgi protein
GWK91_01125	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
GWK91_01130	COG1074	ATP-dependent DNA helicase activity
GWK91_01135	COG0577	efflux transmembrane transporter activity
GWK91_01135	COG1136	(ABC) transporter
GWK91_01170	COG2311	Membrane
GWK91_01175	COG3695	enzyme binding
GWK91_01195	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GWK91_01210	COG1307	EDD domain protein, DegV family
GWK91_01215	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GWK91_01240	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GWK91_01250	COG3639	organic phosphonate transmembrane transporter activity
GWK91_01255	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
GWK91_01270	COG0561	phosphatase activity
GWK91_01275	COG1073	alpha beta
GWK91_01280	COG2151	metal-sulfur cluster biosynthetic enzyme
GWK91_01290	COG0535	radical SAM domain protein
GWK91_01295	COG1968	undecaprenyl-diphosphatase activity
GWK91_01315	COG1744	ABC transporter substrate-binding protein PnrA-like
GWK91_01320	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GWK91_01325	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GWK91_01345	COG0180	Tryptophanyl-tRNA synthetase
GWK91_01380	COG0601	transmembrane transport
GWK91_01385	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GWK91_01390	COG0444	Belongs to the ABC transporter superfamily
GWK91_01395	COG4608	Belongs to the ABC transporter superfamily
GWK91_01410	COG0456	acetyltransferase
GWK91_01415	COG1393	Belongs to the ArsC family
GWK91_01420	COG0861	Integral membrane protein TerC family
GWK91_01430	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GWK91_01440	COG1164	Oligoendopeptidase f
GWK91_01450	COG2346	COG2346, Truncated hemoglobins
GWK91_01455	COG4116	CYTH
GWK91_01460	COG2357	RelA SpoT domain protein
GWK91_01465	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GWK91_01470	COG0564	pseudouridine synthase activity
GWK91_01475	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GWK91_01480	COG0772	Belongs to the SEDS family
GWK91_01485	COG2239	Acts as a magnesium transporter
GWK91_01510	COG2323	membrane
GWK91_01515	COG2153	protein acetylation
GWK91_01525	COG2382	esterase
GWK91_01530	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
GWK91_01540	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GWK91_01550	COG4990	cell redox homeostasis
GWK91_01555	COG2151	metal-sulfur cluster biosynthetic enzyme
GWK91_01575	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GWK91_01590	COG1408	metallophosphoesterase
GWK91_01595	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GWK91_01600	COG0697	spore germination
GWK91_01645	COG0028	Belongs to the TPP enzyme family
GWK91_01650	COG1012	belongs to the aldehyde dehydrogenase family
GWK91_01655	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GWK91_01670	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GWK91_01695	COG2249	NAD(P)H dehydrogenase (quinone) activity
GWK91_01725	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
GWK91_01730	COG0402	S-adenosylhomocysteine deaminase activity
GWK91_01735	COG1131	(ABC) transporter
GWK91_01740	COG1725	Transcriptional regulator
GWK91_01750	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GWK91_01755	COG2133	pyrroloquinoline quinone binding
GWK91_01765	COG0583	DNA-binding transcription factor activity
GWK91_01770	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GWK91_01780	COG1250	3-hydroxyacyl-CoA dehydrogenase
GWK91_01785	COG1902	pentaerythritol trinitrate reductase activity
GWK91_01800	COG1309	transcriptional regulator
GWK91_01805	COG2814	Major facilitator Superfamily
GWK91_01810	COG1119	ATPase activity
GWK91_01815	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
GWK91_01825	COG1012	belongs to the aldehyde dehydrogenase family
GWK91_01860	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GWK91_01865	COG1268	BioY protein
GWK91_01895	COG1289	transmembrane transporter activity
GWK91_01925	COG0697	spore germination
GWK91_01930	COG2304	oxidoreductase activity
GWK91_01945	COG2113	Glycine betaine
GWK91_01950	COG2318	DinB family
GWK91_01970	COG2318	DinB family
GWK91_01975	COG1742	UPF0060 membrane protein
GWK91_02015	COG0697	spore germination
GWK91_02020	COG0531	amino acid
GWK91_02030	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GWK91_02055	COG0670	Belongs to the BI1 family
GWK91_02080	COG0513	Belongs to the DEAD box helicase family
GWK91_02085	COG0494	nUDIX hydrolase
GWK91_02100	COG0693	protein deglycase activity
GWK91_02105	COG3835	regulator
GWK91_02110	COG0247	lactate metabolic process
GWK91_02115	COG0277	FAD linked oxidase domain protein
GWK91_02120	COG2076	Multidrug Resistance protein
GWK91_02125	COG2076	Multidrug Resistance protein
GWK91_02140	COG0346	lactoylglutathione lyase activity
GWK91_02145	COG1301	dicarboxylic acid transport
GWK91_02150	COG2391	methyltransferase activity
GWK91_02155	COG3118	belongs to the thioredoxin family
GWK91_02175	COG1506	peptidase
GWK91_02175	COG0823	Involved in the tonB-independent uptake of proteins
GWK91_02175	COG4946	Tricorn protease homolog
GWK91_02190	COG0697	spore germination
GWK91_02200	COG1794	racemase activity, acting on amino acids and derivatives
GWK91_02215	COG4412	M6 family metalloprotease domain protein
GWK91_02215	COG1404	Belongs to the peptidase S8 family
GWK91_02220	COG2201	protein-glutamate methylesterase activity
GWK91_02235	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GWK91_02240	COG2897	thiosulfate sulfurtransferase activity
GWK91_02245	COG1609	Transcriptional regulator
GWK91_02250	COG1263	PTS System
GWK91_02250	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GWK91_02255	COG1621	beta-fructofuranosidase activity
GWK91_02260	COG2190	(PTS) system
GWK91_02265	COG1940	carbohydrate kinase activity
GWK91_02290	COG0436	Aminotransferase
GWK91_02295	COG4149	molybdate abc transporter
GWK91_02300	COG0328	RNA-DNA hybrid ribonuclease activity
GWK91_02320	COG0604	alcohol dehydrogenase
GWK91_02325	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GWK91_02330	COG0765	amino acid transport
GWK91_02350	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GWK91_02360	COG1418	mRNA catabolic process
GWK91_02365	COG0693	protein deglycase activity
GWK91_02370	COG0840	transmembrane signaling receptor activity
GWK91_02385	COG2198	Histidine kinase
GWK91_02385	COG0643	Histidine kinase
GWK91_02390	COG0835	chemotaxis
GWK91_02395	COG2201	protein-glutamate methylesterase activity
GWK91_02400	COG0840	transmembrane signaling receptor activity
GWK91_02415	COG0640	Transcriptional regulator
GWK91_02420	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
GWK91_02425	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GWK91_02430	COG1125	glycine betaine transport
GWK91_02430	COG0517	IMP dehydrogenase activity
GWK91_02435	COG1174	glycine betaine transport
GWK91_02440	COG1482	cell wall glycoprotein biosynthetic process
GWK91_02450	COG1115	amino acid carrier protein
GWK91_02455	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GWK91_02460	COG2233	PERMEase
GWK91_02465	COG5505	Protein of unknown function (DUF819)
GWK91_02470	COG0318	PFAM AMP-dependent synthetase and ligase
GWK91_02500	COG0697	spore germination
GWK91_02515	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GWK91_02520	COG1388	LysM domain
GWK91_02520	COG0791	NLP P60 protein
GWK91_02530	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GWK91_02555	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
GWK91_02560	COG0351	phosphomethylpyrimidine kinase
GWK91_02565	COG0352	thiamine-phosphate diphosphorylase activity
GWK91_02570	COG4667	esterase of the alpha-beta hydrolase superfamily
GWK91_02595	COG1937	Protein conserved in bacteria
GWK91_02600	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GWK91_02605	COG0425	Belongs to the sulfur carrier protein TusA family
GWK91_02605	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GWK91_02610	COG2210	Belongs to the sulfur carrier protein TusA family
GWK91_02615	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GWK91_02615	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GWK91_02620	COG0425	Belongs to the sulfur carrier protein TusA family
GWK91_02625	COG0730	response to heat
GWK91_02635	COG0390	transport system, permease component
GWK91_02640	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GWK91_02645	COG0446	pyridine nucleotide-disulphide oxidoreductase
GWK91_02650	COG1959	2 iron, 2 sulfur cluster binding
GWK91_02655	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GWK91_02655	COG1017	nitric oxide dioxygenase activity
GWK91_02660	COG0431	NADPH-dependent FMN reductase
GWK91_02670	COG0385	Bile acid
GWK91_02685	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GWK91_02695	COG0318	PFAM AMP-dependent synthetase and ligase
GWK91_02700	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
GWK91_02735	COG3706	GGDEF domain
GWK91_02735	COG4251	negative regulation of phosphorylation
GWK91_02735	COG5001	Diguanylate cyclase
GWK91_02735	COG2203	Gaf domain
GWK91_02750	COG5001	Diguanylate cyclase
GWK91_02770	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GWK91_02800	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GWK91_02845	COG0604	alcohol dehydrogenase
GWK91_02850	COG0406	alpha-ribazole phosphatase activity
GWK91_02865	COG1073	alpha beta
GWK91_02870	COG0716	FMN binding
GWK91_02875	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GWK91_02880	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GWK91_02895	COG0604	alcohol dehydrogenase
GWK91_02900	COG0003	Pfam Anion-transporting ATPase
GWK91_02910	COG1966	Carbon starvation protein
GWK91_02935	COG2252	PERMEase
GWK91_02940	COG1331	Highly conserved protein containing a thioredoxin domain
GWK91_02945	COG2002	toxin-antitoxin pair type II binding
GWK91_02950	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GWK91_02955	COG0251	oxidation-reduction process
GWK91_02960	COG2223	nitrite transmembrane transporter activity
GWK91_02965	COG1763	Mo-molybdopterin cofactor biosynthetic process
GWK91_02970	COG0314	molybdopterin synthase activity
GWK91_02980	COG0315	cyclic pyranopterin monophosphate synthase activity
GWK91_02990	COG3290	protein histidine kinase activity
GWK91_02990	COG3829	transcription factor binding
GWK91_02995	COG1024	Enoyl-CoA hydratase
GWK91_03000	COG0511	ligase activity, forming carbon-carbon bonds
GWK91_03015	COG1960	acyl-CoA dehydrogenase activity
GWK91_03020	COG1960	acyl-CoA dehydrogenase activity
GWK91_03025	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GWK91_03030	COG0318	PFAM AMP-dependent synthetase and ligase
GWK91_03035	COG2030	dehydratase
GWK91_03035	COG1012	belongs to the aldehyde dehydrogenase family
GWK91_03045	COG0439	Biotin carboxylase
GWK91_03055	COG0521	Mo-molybdopterin cofactor biosynthetic process
GWK91_03060	COG0303	'Molybdopterin
GWK91_03080	COG2814	Major facilitator Superfamily
GWK91_03090	COG0753	catalase activity
GWK91_03115	COG1752	Esterase of the alpha-beta hydrolase superfamily
GWK91_03130	COG1595	DNA-templated transcription, initiation
GWK91_03140	COG2323	membrane
GWK91_03185	COG0456	acetyltransferase
GWK91_03195	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GWK91_03225	COG4989	oxidoreductase activity
GWK91_03250	COG3935	DnaD domain protein
GWK91_03285	COG4326	sporulation control protein
GWK91_03290	COG0386	Belongs to the glutathione peroxidase family
GWK91_03310	COG2234	aminopeptidase activity
GWK91_03315	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GWK91_03325	COG0739	heme binding
GWK91_03325	COG0741	lytic transglycosylase activity
GWK91_03325	COG1196	nuclear chromosome segregation
GWK91_03330	COG0791	NLP P60 protein
GWK91_03335	COG3069	C4-dicarboxylate transmembrane transporter activity
GWK91_03365	COG0778	Nitroreductase
GWK91_03375	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
GWK91_03380	COG3285	dna ligase
GWK91_03380	COG1793	dna ligase
GWK91_03385	COG2226	methyltransferase
GWK91_03395	COG2814	Major facilitator Superfamily
GWK91_03400	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
GWK91_03455	COG2385	sporulation resulting in formation of a cellular spore
GWK91_03455	COG2247	cell wall binding repeat
GWK91_03465	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
GWK91_03465	COG2885	chlorophyll binding
GWK91_03480	COG0628	permease
GWK91_03490	COG5522	Integral membrane protein (intg_mem_TP0381)
GWK91_03505	COG0492	ferredoxin-NADP+ reductase activity
GWK91_03515	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GWK91_03520	COG3300	MHYT domain
GWK91_03520	COG5001	Diguanylate cyclase
GWK91_03525	COG0500	methyltransferase
GWK91_03530	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GWK91_03555	COG0681	Belongs to the peptidase S26 family
GWK91_03575	COG0681	Belongs to the peptidase S26 family
GWK91_03595	COG0436	Aminotransferase
GWK91_03620	COG0393	Putative heavy-metal-binding
GWK91_03630	COG1999	signal sequence binding
GWK91_03635	COG1408	metallophosphoesterase
GWK91_03640	COG1272	protein, Hemolysin III
GWK91_03650	COG0517	IMP dehydrogenase activity
GWK91_03655	COG2171	N-acyltransferase activity
GWK91_03660	COG1473	amidohydrolase
GWK91_03670	COG0024	Methionine aminopeptidase
GWK91_03675	COG0668	transmembrane transport
GWK91_03680	COG0450	alkyl hydroperoxide reductase
GWK91_03685	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GWK91_03690	COG5577	PFAM Coat F domain
GWK91_03700	COG1132	(ABC) transporter
GWK91_03705	COG1132	(ABC) transporter
GWK91_03710	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
GWK91_03715	COG0569	domain protein
GWK91_03720	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
GWK91_03730	COG0242	peptide deformylase activity
GWK91_03745	COG0022	dehydrogenase e1 component
GWK91_03765	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GWK91_03775	COG0726	polysaccharide deacetylase
GWK91_03795	COG4476	Belongs to the UPF0223 family
GWK91_03800	COG4493	Belongs to the UPF0637 family
GWK91_03805	COG0483	inositol monophosphate 1-phosphatase activity
GWK91_03825	COG4896	Protein conserved in bacteria
GWK91_03835	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
GWK91_03840	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
GWK91_03845	COG2066	Belongs to the glutaminase family
GWK91_03850	COG4838	Belongs to the UPF0358 family
GWK91_03855	COG0772	Belongs to the SEDS family
GWK91_03860	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
GWK91_03865	COG1612	heme a metabolic process
GWK91_03870	COG0109	protoheme IX farnesyltransferase activity
GWK91_03875	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GWK91_03875	COG2010	Cytochrome c
GWK91_03880	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GWK91_03890	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
GWK91_03895	COG3336	cytochrome c oxidase
GWK91_03920	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
GWK91_03925	COG2340	Cysteine-rich secretory protein family
GWK91_03940	COG3679	Belongs to the UPF0342 family
GWK91_03945	COG4471	UPF0298 protein
GWK91_03955	COG0742	ribosomal rna small subunit methyltransferase
GWK91_03965	COG3314	Sporulation integral membrane protein YlbJ
GWK91_03970	COG1752	Esterase of the alpha-beta hydrolase superfamily
GWK91_03975	COG3480	Lon protease (S16) C-terminal proteolytic domain
GWK91_03980	COG1323	Belongs to the UPF0348 family
GWK91_03985	COG1399	metal-binding, possibly nucleic acid-binding protein
GWK91_03990	COG0333	Belongs to the bacterial ribosomal protein bL32 family
GWK91_03995	COG1024	Enoyl-CoA hydratase
GWK91_04005	COG0454	-acetyltransferase
GWK91_04010	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
GWK91_04020	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
GWK91_04025	COG2001	Belongs to the MraZ family
GWK91_04030	COG0275	rRNA processing
GWK91_04045	COG0768	penicillin binding
GWK91_04050	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GWK91_04055	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GWK91_04060	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GWK91_04065	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GWK91_04070	COG0772	Belongs to the SEDS family
GWK91_04075	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
GWK91_04080	COG3879	Bacterial protein of unknown function (DUF881)
GWK91_04085	COG3879	Bacterial protein of unknown function (DUF881)
GWK91_04090	COG3856	small basic protein
GWK91_04095	COG0849	cell division
GWK91_04100	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GWK91_04115	COG1191	sigma factor activity
GWK91_04120	COG1191	sigma factor activity
GWK91_04125	COG1873	PFAM PRC-barrel domain
GWK91_04135	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
GWK91_04140	COG1799	cell septum assembly
GWK91_04145	COG0762	integral membrane protein
GWK91_04150	COG2302	S4 RNA-binding domain
GWK91_04155	COG3599	regulation of cell shape
GWK91_04160	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GWK91_04165	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
GWK91_04170	COG0564	pseudouridine synthase activity
GWK91_04175	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
GWK91_04180	COG2233	PERMEase
GWK91_04195	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
GWK91_04200	COG1561	YicC-like family, N-terminal region
GWK91_04205	COG2052	Domain of unknown function (DUF370)
GWK91_04210	COG0194	GDP metabolic process
GWK91_04215	COG1758	RNA polymerase activity
GWK91_04220	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GWK91_04225	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GWK91_04230	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GWK91_04235	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GWK91_04235	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GWK91_04240	COG0631	protein serine/threonine phosphatase activity
GWK91_04245	COG0515	serine threonine protein kinase
GWK91_04245	COG2815	serine threonine protein kinase
GWK91_04250	COG1162	GTPase activity
GWK91_04255	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GWK91_04260	COG1564	THIamine pyrophosphokinase
GWK91_04270	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GWK91_04275	COG1302	Protein conserved in bacteria
GWK91_04280	COG1461	Dihydroxyacetone kinase
GWK91_04285	COG1760	l-serine dehydratase
GWK91_04290	COG1760	l-serine dehydratase
GWK91_04295	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GWK91_04300	COG1349	DNA-binding transcription factor activity
GWK91_04305	COG0416	fatty acid biosynthetic process
GWK91_04310	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
GWK91_04315	COG1028	Short-chain dehydrogenase reductase Sdr
GWK91_04320	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GWK91_04325	COG0571	ribonuclease III activity
GWK91_04330	COG4840	Belongs to the UPF0435 family
GWK91_04335	COG1196	nuclear chromosome segregation
GWK91_04340	COG0552	protein localization to endoplasmic reticulum
GWK91_04345	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
GWK91_04350	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GWK91_04355	COG0228	four-way junction DNA binding
GWK91_04360	COG1837	Belongs to the UPF0109 family
GWK91_04370	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
GWK91_04375	COG0336	Belongs to the RNA methyltransferase TrmD family
GWK91_04380	COG0335	large ribosomal subunit rRNA binding
GWK91_04390	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
GWK91_04415	COG0045	succinate-CoA ligase (ADP-forming) activity
GWK91_04420	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
GWK91_04425	COG0758	DNA mediated transformation
GWK91_04430	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GWK91_04435	COG4974	Belongs to the 'phage' integrase family
GWK91_04440	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
GWK91_04445	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
GWK91_04450	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
GWK91_04455	COG1815	bacterial-type flagellum-dependent cell motility
GWK91_04460	COG1558	bacterial-type flagellum-dependent cell motility
GWK91_04465	COG1677	Flagellar hook-basal body complex protein FliE
GWK91_04470	COG1766	The M ring may be actively involved in energy transduction
GWK91_04475	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GWK91_04485	COG1157	protein secretion by the type III secretion system
GWK91_04505	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
GWK91_04515	COG4786	Flagellar basal body rod
GWK91_04520	COG1582	Flagellar protein (FlbD)
GWK91_04525	COG1580	Controls the rotational direction of flagella during chemotaxis
GWK91_04530	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GWK91_04535	COG1776	CheC inhibitor of MCP methylation
GWK91_04535	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GWK91_04540	COG2201	protein-glutamate methylesterase activity
GWK91_04545	COG3190	flagellar
GWK91_04550	COG1338	Plays a role in the flagellum-specific transport system
GWK91_04555	COG1987	bacterial-type flagellum assembly
GWK91_04560	COG1684	flagellar biosynthetic protein fliR
GWK91_04570	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GWK91_04575	COG1419	protein localization to endoplasmic reticulum
GWK91_04580	COG0455	bacterial-type flagellum organization
GWK91_04585	COG2201	protein-glutamate methylesterase activity
GWK91_04595	COG1776	CheC inhibitor of MCP methylation
GWK91_04600	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
GWK91_04605	COG1191	sigma factor activity
GWK91_04625	COG0052	Belongs to the universal ribosomal protein uS2 family
GWK91_04630	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
GWK91_04635	COG0528	UMP kinase activity
GWK91_04640	COG0233	cytoplasmic translational termination
GWK91_04645	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GWK91_04650	COG4589	Belongs to the CDS family
GWK91_04660	COG0750	zinc metalloprotease
GWK91_04665	COG0442	prolyl-tRNA aminoacylation
GWK91_04670	COG2176	DNA-directed DNA polymerase activity
GWK91_04680	COG0779	Required for maturation of 30S ribosomal subunits
GWK91_04685	COG0195	Participates in both transcription termination and antitermination
GWK91_04690	COG2740	Nucleic-acid-binding protein implicated in transcription termination
GWK91_04700	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GWK91_04705	COG1550	Protein conserved in bacteria
GWK91_04710	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GWK91_04715	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GWK91_04720	COG0196	riboflavin kinase activity
GWK91_04725	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
GWK91_04730	COG1185	polyribonucleotide nucleotidyltransferase activity
GWK91_04740	COG0726	polysaccharide deacetylase
GWK91_04745	COG0612	Peptidase, M16
GWK91_04750	COG1873	PFAM PRC-barrel domain
GWK91_04755	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GWK91_04760	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GWK91_04765	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GWK91_04770	COG0527	aspartate kinase activity
GWK91_04775	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GWK91_04780	COG0740	serine-type endopeptidase activity
GWK91_04790	COG1674	ftsk spoiiie
GWK91_04795	COG2188	Transcriptional regulator
GWK91_04800	COG0612	Peptidase, M16
GWK91_04805	COG0612	Peptidase, M16
GWK91_04810	COG0300	oxidoreductase activity
GWK91_04825	COG1426	Protein conserved in bacteria
GWK91_04830	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GWK91_04835	COG1546	Belongs to the CinA family
GWK91_04835	COG1058	Belongs to the CinA family
GWK91_04840	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
GWK91_04845	COG1418	mRNA catabolic process
GWK91_04850	COG1692	metallophosphoesterase
GWK91_04855	COG2359	stage V sporulation protein S
GWK91_04865	COG0674	pyruvate-flavodoxin oxidoreductase activity
GWK91_04865	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
GWK91_04870	COG1013	pyruvate-flavodoxin oxidoreductase activity
GWK91_04875	COG1090	epimerase
GWK91_04885	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GWK91_04890	COG4550	Control of competence regulator ComK, YlbF/YmcA
GWK91_04900	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
GWK91_04905	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
GWK91_04910	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GWK91_04915	COG1923	regulation of RNA biosynthetic process
GWK91_04920	COG0464	growth
GWK91_04925	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GWK91_04930	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
GWK91_04935	COG0789	Transcriptional regulator
GWK91_04940	COG0174	glutamine synthetase
GWK91_04945	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GWK91_04950	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
GWK91_04955	COG4224	UPF0291 protein
GWK91_04960	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GWK91_04970	COG3763	UPF0154 protein
GWK91_04975	COG0785	Cytochrome C biogenesis protein
GWK91_04980	COG2111	Na H antiporter
GWK91_04985	COG2201	protein-glutamate methylesterase activity
GWK91_04990	COG4846	Membrane protein involved in cytochrome C biogenesis
GWK91_05010	COG4191	Histidine kinase
GWK91_05035	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
GWK91_05040	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GWK91_05060	COG0824	Thioesterase
GWK91_05070	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
GWK91_05075	COG1469	GTP cyclohydrolase I activity
GWK91_05080	COG2843	Capsule synthesis protein
GWK91_05085	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
GWK91_05090	COG1832	CoA-binding protein
GWK91_05095	COG0187	DNA topoisomerase II activity
GWK91_05100	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GWK91_05110	COG1309	transcriptional regulator
GWK91_05115	COG1960	acyl-CoA dehydrogenase activity
GWK91_05120	COG0511	ligase activity, forming carbon-carbon bonds
GWK91_05125	COG1024	Enoyl-CoA hydratase
GWK91_05130	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GWK91_05135	COG2226	methyltransferase
GWK91_05145	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GWK91_05150	COG0456	acetyltransferase
GWK91_05155	COG2814	Major facilitator Superfamily
GWK91_05160	COG3383	formate dehydrogenase (NAD+) activity
GWK91_05175	COG2116	formate transmembrane transporter activity
GWK91_05185	COG1404	Belongs to the peptidase S8 family
GWK91_05205	COG0326	Molecular chaperone. Has ATPase activity
GWK91_05225	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GWK91_05230	COG2022	thiamine diphosphate biosynthetic process
GWK91_05240	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GWK91_05245	COG0352	thiamine-phosphate diphosphorylase activity
GWK91_05250	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
GWK91_05255	COG0582	viral genome integration into host DNA
GWK91_05275	COG0456	acetyltransferase
GWK91_05275	COG1214	PFAM Peptidase M22, glycoprotease
GWK91_05285	COG3192	ethanolamine utilization protein
GWK91_05290	COG1181	Belongs to the D-alanine--D-alanine ligase family
GWK91_05295	COG3773	Cell wall hydrolase
GWK91_05310	COG2059	Chromate
GWK91_05315	COG2059	Chromate
GWK91_05325	COG0427	acetyl-CoA hydrolase
GWK91_05330	COG3279	Response regulator of the LytR AlgR family
GWK91_05335	COG2124	cytochrome p450
GWK91_05360	COG0542	response to heat
GWK91_05365	COG2860	membrane
GWK91_05385	COG0346	lactoylglutathione lyase activity
GWK91_05400	COG0456	acetyltransferase
GWK91_05410	COG1252	NADH dehydrogenase
GWK91_05415	COG4085	toxin activity
GWK91_05415	COG1525	nuclease
GWK91_05415	COG0737	Belongs to the 5'-nucleotidase family
GWK91_05445	COG1024	Enoyl-CoA hydratase
GWK91_05450	COG2045	Belongs to the ComB family
GWK91_05460	COG0183	Belongs to the thiolase family
GWK91_05465	COG1960	acyl-CoA dehydrogenase activity
GWK91_05485	COG1960	acyl-CoA dehydrogenase activity
GWK91_05490	COG0318	PFAM AMP-dependent synthetase and ligase
GWK91_05500	COG1028	Short-chain dehydrogenase reductase Sdr
GWK91_05520	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
GWK91_05520	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GWK91_05530	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GWK91_05555	COG2027	D-alanyl-D-alanine carboxypeptidase
GWK91_05560	COG2996	Protein conserved in bacteria
GWK91_05580	COG0564	pseudouridine synthase activity
GWK91_05605	COG2839	Protein conserved in bacteria
GWK91_05625	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GWK91_05635	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GWK91_05640	COG2323	membrane
GWK91_05645	COG2181	nitrate reductase activity
GWK91_05655	COG1140	nitrate reductase beta subunit
GWK91_05660	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
GWK91_05680	COG4191	Histidine kinase
GWK91_05705	COG0626	cystathionine gamma-synthase activity
GWK91_05710	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GWK91_05715	COG1854	S-ribosylhomocysteine lyase activity
GWK91_05720	COG2226	methyltransferase
GWK91_05730	COG0735	belongs to the Fur family
GWK91_05735	COG0753	catalase activity
GWK91_05740	COG0714	Associated with various cellular activities
GWK91_05745	COG4548	von Willebrand factor, type A
GWK91_05760	COG4294	response to UV
GWK91_05770	COG1737	Transcriptional regulator
GWK91_05775	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GWK91_05780	COG0725	ABC transporter, periplasmic molybdate-binding protein
GWK91_05785	COG0746	molybdenum cofactor guanylyltransferase activity
GWK91_05790	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GWK91_05795	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GWK91_05805	COG2181	nitrate reductase activity
GWK91_05810	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
GWK91_05815	COG1140	nitrate reductase beta subunit
GWK91_05820	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
GWK91_05840	COG0455	bacterial-type flagellum organization
GWK91_05880	COG5002	protein histidine kinase activity
GWK91_05885	COG2205	protein histidine kinase activity
GWK91_05890	COG0488	(ABC) transporter
GWK91_05895	COG0513	Belongs to the DEAD box helicase family
GWK91_05900	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
GWK91_05905	COG3191	aminopeptidase activity
GWK91_05930	COG1489	DNA binding
GWK91_05940	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GWK91_05940	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GWK91_05950	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
GWK91_05955	COG2084	Dehydrogenase
GWK91_05970	COG0419	ATPase involved in DNA repair
GWK91_05975	COG0420	3'-5' exonuclease activity
GWK91_05990	COG4479	Belongs to the UPF0346 family
GWK91_05995	COG0805	protein transport
GWK91_06000	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GWK91_06005	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GWK91_06015	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
GWK91_06020	COG1388	LysM domain
GWK91_06020	COG0791	NLP P60 protein
GWK91_06025	COG1418	mRNA catabolic process
GWK91_06030	COG1801	Protein of unknown function DUF72
GWK91_06040	COG1278	Cold shock
GWK91_06045	COG0741	lytic transglycosylase activity
GWK91_06050	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
GWK91_06055	COG1755	Isoprenylcysteine carboxyl methyltransferase
GWK91_06060	COG3424	synthase
GWK91_06065	COG1028	Short-chain dehydrogenase reductase Sdr
GWK91_06075	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GWK91_06080	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GWK91_06085	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
GWK91_06090	COG0860	N-Acetylmuramoyl-L-alanine amidase
GWK91_06095	COG0116	Belongs to the methyltransferase superfamily
GWK91_06105	COG3599	regulation of cell shape
GWK91_06110	COG4474	Belongs to the UPF0398 family
GWK91_06120	COG0295	cytidine deaminase activity
GWK91_06140	COG3331	DNA recombination
GWK91_06145	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GWK91_06145	COG4499	WXG100 protein secretion system (Wss), protein YukC
GWK91_06150	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GWK91_06155	COG3935	DnaD domain protein
GWK91_06160	COG0017	Asparaginyl-tRNA synthetase
GWK91_06165	COG0436	Aminotransferase
GWK91_06185	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GWK91_06185	COG1199	ATP-dependent helicase activity
GWK91_06190	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
GWK91_06195	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
GWK91_06200	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
GWK91_06210	COG0617	tRNA 3'-terminal CCA addition
GWK91_06215	COG0438	transferase activity, transferring glycosyl groups
GWK91_06220	COG1803	Methylglyoxal synthase
GWK91_06225	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
GWK91_06230	COG1694	Mazg nucleotide pyrophosphohydrolase
GWK91_06235	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GWK91_06240	COG2738	Putative neutral zinc metallopeptidase
GWK91_06250	COG4347	Protein of unknown function (DUF1405)
GWK91_06260	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
GWK91_06280	COG0457	Tetratricopeptide repeat
GWK91_06290	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
GWK91_06295	COG0287	Prephenate dehydrogenase
GWK91_06300	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GWK91_06305	COG4401	Chorismate mutase type I
GWK91_06310	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GWK91_06315	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
GWK91_06320	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
GWK91_06325	COG0105	UTP biosynthetic process
GWK91_06330	COG0142	geranyltranstransferase activity
GWK91_06335	COG2226	methyltransferase
GWK91_06355	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
GWK91_06375	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GWK91_06380	COG1160	GTP binding
GWK91_06390	COG1304	FMN binding
GWK91_06395	COG0539	negative regulation of cytoplasmic translation
GWK91_06400	COG0204	Acyl-transferase
GWK91_06405	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GWK91_06420	COG2959	enzyme of heme biosynthesis
GWK91_06425	COG3409	Peptidoglycan-binding domain 1 protein
GWK91_06425	COG3773	Cell wall hydrolase
GWK91_06430	COG2339	peptidase activity
GWK91_06440	COG0492	ferredoxin-NADP+ reductase activity
GWK91_06445	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GWK91_06450	COG4862	establishment of competence for transformation
GWK91_06455	COG1408	metallophosphoesterase
GWK91_06475	COG0514	ATP-dependent DNA helicase (RecQ)
GWK91_06480	COG4955	Helix-turn-helix domain
GWK91_06495	COG1595	DNA-templated transcription, initiation
GWK91_06500	COG5002	protein histidine kinase activity
GWK91_06505	COG0745	RESPONSE REGULATOR receiver
GWK91_06510	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GWK91_06515	COG1333	cytochrome c biogenesis protein
GWK91_06520	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GWK91_06525	COG1187	pseudouridine synthase activity
GWK91_06530	COG0700	Nucleoside recognition
GWK91_06535	COG2715	membrane protein required for spore maturation
GWK91_06540	COG1686	Belongs to the peptidase S11 family
GWK91_06545	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
GWK91_06555	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
GWK91_06560	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
GWK91_06570	COG1547	Domain of unknown function (DUF309)
GWK91_06585	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GWK91_06590	COG0019	diaminopimelate decarboxylase activity
GWK91_06595	COG0697	spore germination
GWK91_06605	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GWK91_06635	COG1366	Belongs to the anti-sigma-factor antagonist family
GWK91_06640	COG1686	Belongs to the peptidase S11 family
GWK91_06645	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
GWK91_06655	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
GWK91_06660	COG4974	Belongs to the 'phage' integrase family
GWK91_06670	COG0735	belongs to the Fur family
GWK91_06675	COG1300	Membrane
GWK91_06680	COG1379	DNA repair
GWK91_06685	COG0494	nUDIX hydrolase
GWK91_06690	COG0667	Aldo Keto reductase
GWK91_06705	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GWK91_06710	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GWK91_06715	COG1072	(Pantothenic acid kinase))
GWK91_06720	COG0300	oxidoreductase activity
GWK91_06725	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GWK91_06730	COG4187	Peptidase family M20/M25/M40
GWK91_06735	COG0584	glycerophosphoryl diester phosphodiesterase
GWK91_06740	COG1902	pentaerythritol trinitrate reductase activity
GWK91_06750	COG1012	belongs to the aldehyde dehydrogenase family
GWK91_06755	COG2252	PERMEase
GWK91_06760	COG2226	methyltransferase
GWK91_06765	COG0175	sulfate reduction
GWK91_06780	COG4166	transmembrane transport
GWK91_06790	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GWK91_06795	COG2195	Cleaves the N-terminal amino acid of tripeptides
GWK91_06800	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GWK91_06805	COG0346	lactoylglutathione lyase activity
GWK91_06810	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GWK91_06810	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GWK91_06815	COG1960	acyl-CoA dehydrogenase activity
GWK91_06820	COG2070	2-Nitropropane dioxygenase
GWK91_06825	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GWK91_06830	COG0183	Belongs to the thiolase family
GWK91_06835	COG1309	transcriptional regulator
GWK91_06845	COG4129	membrane
GWK91_06860	COG0508	dehydrogenase complex catalyzes the overall conversion of
GWK91_06865	COG0022	dehydrogenase e1 component
GWK91_06870	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GWK91_06875	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GWK91_06890	COG0280	phosphate acetyltransferase
GWK91_06895	COG3290	protein histidine kinase activity
GWK91_06895	COG3829	transcription factor binding
GWK91_06905	COG0527	aspartate kinase activity
GWK91_06935	COG2197	response regulator
GWK91_06940	COG1022	Amp-dependent synthetase and ligase
GWK91_06955	COG0183	Belongs to the thiolase family
GWK91_06960	COG1028	Short-chain dehydrogenase reductase Sdr
GWK91_06965	COG1024	Enoyl-CoA hydratase
GWK91_06970	COG1960	acyl-CoA dehydrogenase activity
GWK91_06985	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GWK91_06995	COG0750	zinc metalloprotease
GWK91_07000	COG0497	DNA recombination
GWK91_07005	COG1438	arginine binding
GWK91_07010	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
GWK91_07015	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GWK91_07025	COG0142	geranyltranstransferase activity
GWK91_07030	COG1722	exodeoxyribonuclease VII activity
GWK91_07040	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GWK91_07045	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GWK91_07050	COG1302	Protein conserved in bacteria
GWK91_07055	COG0439	Biotin carboxylase
GWK91_07060	COG0511	ligase activity, forming carbon-carbon bonds
GWK91_07100	COG3854	ATPases associated with a variety of cellular activities
GWK91_07105	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GWK91_07110	COG0006	proline dipeptidase activity
GWK91_07115	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
GWK91_07130	COG1752	Esterase of the alpha-beta hydrolase superfamily
GWK91_07135	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GWK91_07140	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GWK91_07150	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GWK91_07155	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GWK91_07160	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GWK91_07180	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GWK91_07185	COG1459	type II secretion system
GWK91_07190	COG4537	Required for transformation and DNA binding
GWK91_07235	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GWK91_07245	COG1368	sulfuric ester hydrolase activity
GWK91_07250	COG1940	carbohydrate kinase activity
GWK91_07255	COG4483	Protein conserved in bacteria
GWK91_07260	COG0697	spore germination
GWK91_07270	COG0705	Rhomboid family
GWK91_07270	COG0457	Tetratricopeptide repeat
GWK91_07280	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GWK91_07300	COG0704	Plays a role in the regulation of phosphate uptake
GWK91_07310	COG0581	inorganic phosphate transmembrane transporter activity
GWK91_07315	COG0573	inorganic phosphate transmembrane transporter activity
GWK91_07320	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GWK91_07330	COG0477	Major facilitator Superfamily
GWK91_07370	COG1283	sodium-dependent phosphate transmembrane transporter activity
GWK91_07385	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
GWK91_07390	COG4709	membrane
GWK91_07400	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
GWK91_07405	COG0513	Belongs to the DEAD box helicase family
GWK91_07410	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
GWK91_07415	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
GWK91_07420	COG2384	SAM-dependent methyltransferase
GWK91_07435	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GWK91_07440	COG0358	DNA primase activity
GWK91_07445	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
GWK91_07450	COG0517	IMP dehydrogenase activity
GWK91_07455	COG1381	Involved in DNA repair and RecF pathway recombination
GWK91_07465	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
GWK91_07470	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
GWK91_07475	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
GWK91_07480	COG1480	7TM receptor with intracellular HD hydrolase
GWK91_07485	COG1702	phosphate starvation-inducible protein PhoH
GWK91_07490	COG0561	phosphatase activity
GWK91_07505	COG4864	UPF0365 protein
GWK91_07510	COG1030	water channel activity
GWK91_07515	COG1610	YqeY-like protein
GWK91_07520	COG0828	Belongs to the bacterial ribosomal protein bS21 family
GWK91_07525	COG1283	sodium-dependent phosphate transmembrane transporter activity
GWK91_07530	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
GWK91_07555	COG0642	Histidine kinase
GWK91_07560	COG0745	RESPONSE REGULATOR receiver
GWK91_07565	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GWK91_07570	COG1385	rRNA (uridine-N3-)-methyltransferase activity
GWK91_07575	COG2264	protein methyltransferase activity
GWK91_07580	COG0484	heat shock protein binding
GWK91_07585	COG0443	Heat shock 70 kDa protein
GWK91_07590	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GWK91_07595	COG1420	regulation of RNA biosynthetic process
GWK91_07600	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GWK91_07605	COG0481	GTPase activity
GWK91_07615	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
GWK91_07620	COG0268	Binds directly to 16S ribosomal RNA
GWK91_07625	COG1466	dna polymerase III delta subunit
GWK91_07635	COG0658	competence protein
GWK91_07635	COG2333	competence protein COMEC
GWK91_07640	COG2131	deaminase
GWK91_07645	COG1555	photosystem II stabilization
GWK91_07645	COG1596	polysaccharide export
GWK91_07650	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GWK91_07655	COG1247	-acetyltransferase
GWK91_07660	COG2226	methyltransferase
GWK91_07665	COG0799	negative regulation of ribosome biogenesis
GWK91_07670	COG1713	HD superfamily hydrolase involved in NAD metabolism
GWK91_07675	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GWK91_07680	COG1534	Rna-binding protein
GWK91_07685	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GWK91_07690	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
GWK91_07695	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
GWK91_07705	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GWK91_07705	COG2111	Na H antiporter
GWK91_07710	COG1006	Multisubunit Na H antiporter MnhC subunit
GWK91_07715	COG0651	ATP synthesis coupled electron transport
GWK91_07725	COG2212	antiporter activity
GWK91_07745	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GWK91_07760	COG0768	penicillin binding
GWK91_07765	COG0768	penicillin binding
GWK91_07770	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GWK91_07775	COG0572	uridine kinase
GWK91_07780	COG4122	O-methyltransferase activity
GWK91_07785	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GWK91_07790	COG3906	Belongs to the UPF0473 family
GWK91_07795	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
GWK91_07800	COG4472	Bacterial protein of unknown function (DUF965)
GWK91_07805	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GWK91_07810	COG0628	permease
GWK91_07820	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GWK91_07830	COG0482	sulfurtransferase activity
GWK91_07835	COG1104	cysteine desulfurase activity
GWK91_07840	COG1959	2 iron, 2 sulfur cluster binding
GWK91_07845	COG2364	Membrane
GWK91_07850	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GWK91_07860	COG0137	argininosuccinate synthase activity
GWK91_07865	COG0165	Argininosuccinate lyase
GWK91_07870	COG0505	Belongs to the CarA family
GWK91_07875	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GWK91_07880	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GWK91_07890	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
GWK91_07895	COG0124	histidyl-tRNA synthetase
GWK91_07905	COG0860	N-Acetylmuramoyl-L-alanine amidase
GWK91_07910	COG1490	D-aminoacyl-tRNA deacylase activity
GWK91_07915	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GWK91_07920	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GWK91_07925	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GWK91_07925	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
GWK91_07930	COG5416	Lipopolysaccharide assembly protein A domain
GWK91_07935	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GWK91_07935	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GWK91_07945	COG2244	polysaccharide biosynthetic process
GWK91_07950	COG2323	membrane
GWK91_07955	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
GWK91_07965	COG1862	Preprotein translocase
GWK91_07970	COG0343	queuine tRNA-ribosyltransferase activity
GWK91_07975	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
GWK91_07985	COG2255	four-way junction helicase activity
GWK91_07990	COG0632	four-way junction helicase activity
GWK91_08000	COG0217	transcriptional regulatory protein
GWK91_08010	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
GWK91_08015	COG1388	LysM domain
GWK91_08020	COG0077	Prephenate dehydratase
GWK91_08025	COG4492	Belongs to the UPF0735 family
GWK91_08030	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GWK91_08040	COG0211	Belongs to the bacterial ribosomal protein bL27 family
GWK91_08045	COG2868	ribosomal protein
GWK91_08050	COG0261	This protein binds to 23S rRNA in the presence of protein L20
GWK91_08055	COG1530	ribonuclease E activity
GWK91_08060	COG1994	Peptidase M50
GWK91_08070	COG0347	Belongs to the P(II) protein family
GWK91_08075	COG0004	ammonium transporteR
GWK91_08080	COG0367	asparagine synthase
GWK91_08085	COG2894	cell division
GWK91_08090	COG0850	regulation of cytokinetic process
GWK91_08105	COG1077	Cell shape determining protein MreB Mrl
GWK91_08110	COG2003	Belongs to the UPF0758 family
GWK91_08115	COG0424	maF-like protein
GWK91_08130	COG3706	GGDEF domain
GWK91_08135	COG0285	dihydrofolate synthase activity
GWK91_08140	COG0525	valine-tRNA ligase activity
GWK91_08155	COG1388	LysM domain
GWK91_08155	COG1388	LysM domain
GWK91_08160	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GWK91_08165	COG0113	porphobilinogen synthase activity
GWK91_08170	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GWK91_08170	COG1587	Uroporphyrinogen-III synthase
GWK91_08175	COG0181	hydroxymethylbilane synthase activity
GWK91_08180	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GWK91_08185	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
GWK91_08195	COG0218	Necessary for normal cell division and for the maintenance of normal septation
GWK91_08200	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GWK91_08205	COG1067	ATP-dependent peptidase activity
GWK91_08205	COG0470	DNA polymerase III
GWK91_08210	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
GWK91_08215	COG0544	peptidyl-prolyl cis-trans isomerase activity
GWK91_08260	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
GWK91_08265	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
GWK91_08270	COG5401	PFAM Sporulation and spore germination
GWK91_08280	COG1846	Transcriptional regulator
GWK91_08285	COG2197	response regulator
GWK91_08290	COG0824	Thioesterase
GWK91_08295	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GWK91_08300	COG1053	succinate dehydrogenase
GWK91_08305	COG2009	succinate dehydrogenase
GWK91_08310	COG1719	4-vinyl reductase, 4VR
GWK91_08315	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GWK91_08320	COG0322	excinuclease ABC activity
GWK91_08325	COG3118	belongs to the thioredoxin family
GWK91_08330	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
GWK91_08335	COG2086	electron transfer activity
GWK91_08340	COG1024	Enoyl-CoA hydratase
GWK91_08345	COG1309	transcriptional regulator
GWK91_08350	COG0318	PFAM AMP-dependent synthetase and ligase
GWK91_08355	COG3766	membrane
GWK91_08360	COG1193	negative regulation of DNA recombination
GWK91_08365	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
GWK91_08365	COG1796	DNA polymerase
GWK91_08370	COG1286	toxin biosynthetic process
GWK91_08375	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
GWK91_08380	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GWK91_08390	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GWK91_08390	COG0072	phenylalanine-tRNA ligase activity
GWK91_08395	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GWK91_08400	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GWK91_08410	COG1363	Peptidase, m42
GWK91_08425	COG0398	Pfam SNARE associated Golgi protein
GWK91_08430	COG3326	Membrane
GWK91_08435	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
GWK91_08440	COG0291	Belongs to the bacterial ribosomal protein bL35 family
GWK91_08445	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
GWK91_08450	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GWK91_08460	COG1484	DNA-dependent DNA replication
GWK91_08465	COG3611	Membrane attachment protein
GWK91_08470	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GWK91_08475	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
GWK91_08480	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GWK91_08485	COG0237	dephospho-CoA kinase activity
GWK91_08490	COG1971	Probably functions as a manganese efflux pump
GWK91_08495	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GWK91_08500	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GWK91_08500	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GWK91_08505	COG0330	HflC and HflK could
GWK91_08510	COG0330	HflC and HflK could
GWK91_08515	COG5002	protein histidine kinase activity
GWK91_08520	COG0745	RESPONSE REGULATOR receiver
GWK91_08530	COG0039	L-malate dehydrogenase activity
GWK91_08535	COG0538	isocitrate dehydrogenase activity
GWK91_08540	COG0372	Belongs to the citrate synthase family
GWK91_08545	COG2707	UPF0756 membrane protein
GWK91_08550	COG0628	permease
GWK91_08555	COG3030	protein affecting phage T7 exclusion by the F plasmid
GWK91_08570	COG0825	malonyl-CoA metabolic process
GWK91_08575	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
GWK91_08585	COG0281	malic enzyme
GWK91_08590	COG0587	DNA-directed DNA polymerase activity
GWK91_08610	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
GWK91_08620	COG4109	DRTGG domain
GWK91_08630	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
GWK91_08635	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
GWK91_08640	COG3766	membrane
GWK91_08650	COG1842	Phage shock protein A
GWK91_08660	COG0006	proline dipeptidase activity
GWK91_08670	COG1028	Short-chain dehydrogenase reductase Sdr
GWK91_08675	COG0589	response to stress
GWK91_08680	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GWK91_08685	COG0827	DNA restriction-modification system
GWK91_08690	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
GWK91_08695	COG3874	Sporulation protein YtfJ
GWK91_08705	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GWK91_08710	COG1574	metal-dependent hydrolase with the TIM-barrel fold
GWK91_08720	COG0301	tRNA thio-modification
GWK91_08725	COG1104	cysteine desulfurase activity
GWK91_08735	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
GWK91_08740	COG1309	transcriptional regulator
GWK91_08745	COG1956	GAF domain-containing protein
GWK91_08750	COG2203	Gaf domain
GWK91_08750	COG2199	diguanylate cyclase activity
GWK91_08755	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
GWK91_08770	COG2323	membrane
GWK91_08780	COG4640	response to antibiotic
GWK91_08785	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GWK91_08795	COG0454	-acetyltransferase
GWK91_08800	COG0517	IMP dehydrogenase activity
GWK91_08805	COG0123	including yeast histone deacetylase and acetoin utilization protein
GWK91_08825	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
GWK91_08825	COG1605	Chorismate mutase
GWK91_08835	COG3118	belongs to the thioredoxin family
GWK91_08840	COG4980	gas vesicle protein
GWK91_08850	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GWK91_08860	COG1674	ftsk spoiiie
GWK91_08865	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GWK91_08870	COG4848	Belongs to the UPF0354 family
GWK91_08875	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GWK91_08880	COG0840	transmembrane signaling receptor activity
GWK91_08895	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
GWK91_08900	COG1363	Peptidase, m42
GWK91_08910	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GWK91_08915	COG0220	tRNA (guanine-N7-)-methyltransferase activity
GWK91_08920	COG0510	thiamine kinase activity
GWK91_08925	COG1597	lipid kinase activity
GWK91_08940	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GWK91_08945	COG1349	DNA-binding transcription factor activity
GWK91_08950	COG1187	pseudouridine synthase activity
GWK91_08955	COG2244	polysaccharide biosynthetic process
GWK91_08960	COG2081	HI0933 family
GWK91_08965	COG1272	protein, Hemolysin III
GWK91_08985	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GWK91_08995	COG1272	protein, Hemolysin III
GWK91_09015	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GWK91_09020	COG0495	leucyl-tRNA aminoacylation
GWK91_09025	COG1131	(ABC) transporter
GWK91_09030	COG1725	Transcriptional regulator
GWK91_09045	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
GWK91_09055	COG2267	carboxylic ester hydrolase activity
GWK91_09060	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
GWK91_09065	COG4990	cell redox homeostasis
GWK91_09070	COG0367	asparagine synthase
GWK91_09075	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
GWK91_09080	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
GWK91_09085	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GWK91_09090	COG1116	anion transmembrane transporter activity
GWK91_09095	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GWK91_09100	COG0494	nUDIX hydrolase
GWK91_09120	COG1120	ATPase activity
GWK91_09125	COG4948	Mandelate Racemase Muconate Lactonizing
GWK91_09130	COG0318	PFAM AMP-dependent synthetase and ligase
GWK91_09135	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
GWK91_09140	COG0596	Alpha beta hydrolase
GWK91_09145	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
GWK91_09150	COG1169	isochorismate synthase
GWK91_09155	COG2050	protein possibly involved in aromatic compounds catabolism
GWK91_09160	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
GWK91_09170	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GWK91_09180	COG0166	Belongs to the GPI family
GWK91_09185	COG1979	alcohol dehydrogenase
GWK91_09190	COG1098	S1 RNA binding domain
GWK91_09195	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
GWK91_09200	COG2032	superoxide dismutase activity
GWK91_09210	COG0813	purine-nucleoside phosphorylase activity
GWK91_09220	COG1268	BioY protein
GWK91_09225	COG3584	3D domain protein
GWK91_09235	COG1252	NADH dehydrogenase
GWK91_09250	COG0316	Belongs to the HesB IscA family
GWK91_09255	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
GWK91_09260	COG4837	Protein of unknown function (DUF1462)
GWK91_09265	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
GWK91_09275	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GWK91_09280	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GWK91_09285	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GWK91_09290	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
GWK91_09295	COG0647	UMP catabolic process
GWK91_09300	COG2445	Protein of unknown function DUF86
GWK91_09315	COG4470	Protein conserved in bacteria
GWK91_09325	COG0739	heme binding
GWK91_09335	COG0733	neurotransmitter:sodium symporter activity
GWK91_09340	COG1757	Na H antiporter
GWK91_09350	COG3377	Domain of unknown function (DUF1805)
GWK91_09355	COG0737	Belongs to the 5'-nucleotidase family
GWK91_09360	COG0730	response to heat
GWK91_09365	COG0719	Fe-S assembly protein
GWK91_09370	COG0822	iron-sulfur transferase activity
GWK91_09375	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GWK91_09380	COG0719	Fe-S assembly protein
GWK91_09385	COG0396	ATPase activity
GWK91_09390	COG1464	Belongs to the NlpA lipoprotein family
GWK91_09395	COG2011	ABC-type metal ion transport system permease component
GWK91_09400	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GWK91_09405	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GWK91_09410	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
GWK91_09415	COG0509	glycine decarboxylation via glycine cleavage system
GWK91_09420	COG1393	Belongs to the ArsC family
GWK91_09425	COG1960	acyl-CoA dehydrogenase activity
GWK91_09430	COG0183	Belongs to the thiolase family
GWK91_09435	COG1024	Enoyl-CoA hydratase
GWK91_09435	COG1250	3-hydroxyacyl-CoA dehydrogenase
GWK91_09445	COG5577	PFAM Coat F domain
GWK91_09460	COG1121	(ABC) transporter
GWK91_09465	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GWK91_09470	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GWK91_09480	COG2508	Transcriptional regulator
GWK91_09490	COG1473	amidohydrolase
GWK91_09500	COG1012	belongs to the aldehyde dehydrogenase family
GWK91_09505	COG0006	proline dipeptidase activity
GWK91_09540	COG1131	(ABC) transporter
GWK91_09550	COG1960	acyl-CoA dehydrogenase activity
GWK91_09555	COG2133	pyrroloquinoline quinone binding
GWK91_09560	COG1028	Short-chain dehydrogenase reductase Sdr
GWK91_09565	COG3594	Acyltransferase
GWK91_09575	COG4607	ABC-type enterochelin transport system periplasmic component
GWK91_09580	COG4604	ABC transporter, ATP-binding protein
GWK91_09585	COG4605	iron ion homeostasis
GWK91_09590	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GWK91_09600	COG1413	lyase activity
GWK91_09605	COG2070	2-Nitropropane dioxygenase
GWK91_09620	COG2358	TRAP transporter, solute receptor (TAXI family
GWK91_09625	COG4565	transcriptional regulatory protein
GWK91_09630	COG3290	protein histidine kinase activity
GWK91_09635	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GWK91_09650	COG2112	serine threonine protein kinase
GWK91_09655	COG0318	PFAM AMP-dependent synthetase and ligase
GWK91_09690	COG2130	NADP-dependent
GWK91_09710	COG2217	Heavy metal translocating P-type atpase
GWK91_09715	COG1937	Protein conserved in bacteria
GWK91_09720	COG1012	belongs to the aldehyde dehydrogenase family
GWK91_09730	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GWK91_09740	COG0590	tRNA wobble adenosine to inosine editing
GWK91_09745	COG0656	L-ascorbic acid biosynthetic process
GWK91_09750	COG0493	'glutamate synthase
GWK91_09755	COG0070	glutamate synthase
GWK91_09755	COG0069	glutamate synthase activity
GWK91_09755	COG0067	glutamate synthase
GWK91_09760	COG0583	DNA-binding transcription factor activity
GWK91_09765	COG2368	4-hydroxyphenylacetate
GWK91_09775	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
GWK91_09785	COG0557	exoribonuclease II activity
GWK91_09795	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GWK91_09800	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GWK91_09820	COG0148	phosphopyruvate hydratase activity
GWK91_09825	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
GWK91_09830	COG0149	triose-phosphate isomerase activity
GWK91_09835	COG0126	phosphoglycerate kinase activity
GWK91_09840	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GWK91_09855	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
GWK91_09860	COG2155	Conserved Protein
GWK91_09870	COG0740	serine-type endopeptidase activity
GWK91_09875	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GWK91_09880	COG1481	regulation of sporulation
GWK91_09885	COG0391	Required for morphogenesis under gluconeogenic growth conditions
GWK91_09890	COG1660	Displays ATPase and GTPase activities
GWK91_09895	COG1051	belongs to the nudix hydrolase family
GWK91_09900	COG0492	ferredoxin-NADP+ reductase activity
GWK91_09910	COG0768	penicillin binding
GWK91_09915	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GWK91_09920	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GWK91_09925	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GWK91_09930	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
GWK91_09935	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
GWK91_09940	COG1461	Dihydroxyacetone kinase
GWK91_09945	COG2376	Dihydroxyacetone kinase
GWK91_09950	COG2801	Transposase and inactivated derivatives
GWK91_09960	COG0110	maltose O-acetyltransferase activity
GWK91_09970	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
GWK91_09975	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
GWK91_09980	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
GWK91_09985	COG1950	PFAM Membrane protein of
GWK91_09990	COG3595	metallopeptidase activity
GWK91_09995	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GWK91_10000	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GWK91_10005	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GWK91_10010	COG0556	nucleotide-excision repair
GWK91_10015	COG2197	response regulator
GWK91_10020	COG0366	Alpha amylase catalytic
GWK91_10025	COG2188	Transcriptional regulator
GWK91_10030	COG0366	Alpha amylase catalytic
GWK91_10035	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GWK91_10035	COG1263	PTS System
GWK91_10045	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GWK91_10050	COG3409	Peptidoglycan-binding domain 1 protein
GWK91_10050	COG0793	Belongs to the peptidase S41A family
GWK91_10055	COG0739	heme binding
GWK91_10060	COG2177	Part of the ABC transporter FtsEX involved in
GWK91_10065	COG2884	Cell division ATP-binding protein ftsE
GWK91_10075	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GWK91_10085	COG0653	protein targeting
GWK91_10090	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GWK91_10105	COG1516	flagellar protein fliS
GWK91_10110	COG1334	flagellar protein FlaG
GWK91_10115	COG0840	transmembrane signaling receptor activity
GWK91_10135	COG0840	transmembrane signaling receptor activity
GWK91_10140	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
GWK91_10155	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
GWK91_10160	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
GWK91_10170	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GWK91_10175	COG4786	Flagellar basal body rod
GWK91_10175	COG1256	bacterial-type flagellum assembly
GWK91_10195	COG1040	competence protein
GWK91_10200	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
GWK91_10205	COG1307	EDD domain protein, DegV family
GWK91_10220	COG2197	response regulator
GWK91_10225	COG4585	Histidine kinase
GWK91_10230	COG1739	Uncharacterized protein family UPF0029
GWK91_10245	COG1316	TRANSCRIPTIONal
GWK91_10250	COG1316	TRANSCRIPTIONal
GWK91_10255	COG1943	Transposase
GWK91_10260	COG1082	Xylose isomerase domain protein TIM barrel
GWK91_10265	COG1609	Transcriptional regulator
GWK91_10275	COG1129	ABC transporter
GWK91_10280	COG1172	Belongs to the binding-protein-dependent transport system permease family
GWK91_10285	COG0673	inositol 2-dehydrogenase activity
GWK91_10290	COG0395	ABC-type sugar transport system, permease component
GWK91_10295	COG1175	transmembrane transport
GWK91_10305	COG2207	Transcriptional regulator
GWK91_10305	COG4753	response regulator
GWK91_10310	COG2972	Histidine kinase
GWK91_10320	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
GWK91_10325	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GWK91_10330	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
GWK91_10335	COG3842	ATPase activity
GWK91_10340	COG1472	Belongs to the glycosyl hydrolase 3 family
GWK91_10345	COG2508	Transcriptional regulator
GWK91_10350	COG0514	ATP-dependent DNA helicase (RecQ)
GWK91_10355	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GWK91_10365	COG1028	Short-chain dehydrogenase reductase Sdr
GWK91_10370	COG0363	glucosamine-6-phosphate deaminase activity
GWK91_10375	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GWK91_10380	COG2188	Transcriptional regulator
GWK91_10395	COG1012	belongs to the aldehyde dehydrogenase family
GWK91_10400	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GWK91_10405	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GWK91_10410	COG0579	oxidoreductase
GWK91_10415	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GWK91_10430	COG1388	LysM domain
GWK91_10430	COG5632	N-Acetylmuramoyl-L-alanine amidase
GWK91_10430	COG3409	Peptidoglycan-binding domain 1 protein
GWK91_10435	COG1254	Belongs to the acylphosphatase family
GWK91_10440	COG0247	lactate metabolic process
GWK91_10445	COG0277	FAD linked oxidase domain protein
GWK91_10450	COG1028	Short-chain dehydrogenase reductase Sdr
GWK91_10455	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GWK91_10460	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
GWK91_10465	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
GWK91_10480	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GWK91_10495	COG4106	trans-aconitate 2-methyltransferase activity
GWK91_10510	COG0328	RNA-DNA hybrid ribonuclease activity
GWK91_10520	COG1063	alcohol dehydrogenase
GWK91_10530	COG1414	Transcriptional regulator
GWK91_10540	COG0473	3-isopropylmalate dehydrogenase activity
GWK91_10545	COG0183	Belongs to the thiolase family
GWK91_10550	COG1960	acyl-CoA dehydrogenase activity
GWK91_10555	COG1024	Enoyl-CoA hydratase
GWK91_10560	COG1250	3-hydroxyacyl-CoA dehydrogenase
GWK91_10575	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
GWK91_10580	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
GWK91_10590	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GWK91_10595	COG0210	DNA helicase
GWK91_10605	COG0861	Integral membrane protein TerC family
GWK91_10630	COG2706	6-phosphogluconolactonase activity
GWK91_10640	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GWK91_10645	COG0840	transmembrane signaling receptor activity
GWK91_10650	COG1114	Component of the transport system for branched-chain amino acids
GWK91_10655	COG1802	Transcriptional regulator
GWK91_10660	COG0318	PFAM AMP-dependent synthetase and ligase
GWK91_10665	COG4145	pantothenate transmembrane transporter activity
GWK91_10675	COG1879	ABC-type sugar transport system periplasmic component
GWK91_10680	COG1172	Belongs to the binding-protein-dependent transport system permease family
GWK91_10685	COG1129	ABC transporter
GWK91_10690	COG1869	D-ribose catabolic process
GWK91_10695	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GWK91_10700	COG1609	Transcriptional regulator
GWK91_10705	COG2190	(PTS) system
GWK91_10705	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GWK91_10705	COG1263	PTS System
GWK91_10710	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
GWK91_10715	COG1737	Transcriptional regulator
GWK91_10720	COG1757	Na H antiporter
GWK91_10725	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GWK91_10730	COG3829	transcription factor binding
GWK91_10730	COG3290	protein histidine kinase activity
GWK91_10735	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
GWK91_10740	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
GWK91_10745	COG2188	Transcriptional regulator
GWK91_10750	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GWK91_10760	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GWK91_10765	COG1957	nucleoside hydrolase
GWK91_10775	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GWK91_10780	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
GWK91_10790	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GWK91_10795	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GWK91_10795	COG1522	sequence-specific DNA binding
GWK91_10810	COG0318	PFAM AMP-dependent synthetase and ligase
GWK91_10815	COG2358	TRAP transporter, solute receptor (TAXI family
GWK91_10825	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
GWK91_10835	COG1028	Short-chain dehydrogenase reductase Sdr
GWK91_10855	COG1012	belongs to the aldehyde dehydrogenase family
GWK91_10860	COG0318	PFAM AMP-dependent synthetase and ligase
GWK91_10865	COG1960	acyl-CoA dehydrogenase activity
GWK91_10870	COG1960	acyl-CoA dehydrogenase activity
GWK91_10890	COG2030	dehydratase
GWK91_10910	COG0693	protein deglycase activity
GWK91_10915	COG1830	Aldolase
GWK91_10920	COG1879	ABC-type sugar transport system periplasmic component
GWK91_10925	COG1172	Belongs to the binding-protein-dependent transport system permease family
GWK91_10945	COG1070	Carbohydrate kinase
GWK91_10955	COG1979	alcohol dehydrogenase
GWK91_10965	COG0529	Catalyzes the synthesis of activated sulfate
GWK91_10970	COG3273	potassium ion transport
GWK91_10970	COG0471	metal ion transport
GWK91_10975	COG2046	Belongs to the sulfate adenylyltransferase family
GWK91_10980	COG2197	response regulator
GWK91_10985	COG0840	transmembrane signaling receptor activity
GWK91_11000	COG0154	amidase activity
GWK91_11105	COG1091	dTDP-4-dehydrorhamnose reductase activity
GWK91_11135	COG0438	transferase activity, transferring glycosyl groups
GWK91_11140	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
GWK91_11150	COG1086	Polysaccharide biosynthesis protein
GWK91_11165	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GWK91_11170	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GWK91_11180	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GWK91_11185	COG4464	protein tyrosine phosphatase activity
GWK91_11190	COG0489	protein tyrosine kinase activity
GWK91_11195	COG3944	biosynthesis protein
GWK91_11205	COG0110	maltose O-acetyltransferase activity
GWK91_11215	COG0438	transferase activity, transferring glycosyl groups
GWK91_11220	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
GWK91_11220	COG0662	Cupin 2, conserved barrel domain protein
GWK91_11250	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GWK91_11255	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
GWK91_11260	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GWK91_11280	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GWK91_11285	COG0463	Glycosyl transferase, family 2
GWK91_11315	COG0728	peptidoglycan biosynthetic process
GWK91_11330	COG0438	transferase activity, transferring glycosyl groups
GWK91_11365	COG1215	transferase activity, transferring glycosyl groups
GWK91_11365	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
GWK91_11370	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
GWK91_11375	COG4193	domain, Protein
GWK91_11385	COG1134	teichoic acid transport
GWK91_11390	COG1682	transport, permease protein
GWK91_11395	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
GWK91_11400	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
GWK91_11405	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
GWK91_11410	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GWK91_11415	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
GWK91_11420	COG3858	chitin binding
GWK91_11425	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GWK91_11450	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GWK91_11460	COG4786	Flagellar basal body rod
GWK91_11465	COG4786	Flagellar basal body rod
GWK91_11470	COG1077	Cell shape determining protein MreB Mrl
GWK91_11475	COG1609	Transcriptional regulator
GWK91_11480	COG0471	metal ion transport
GWK91_11500	COG2385	sporulation resulting in formation of a cellular spore
GWK91_11505	COG0142	geranyltranstransferase activity
GWK91_11510	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GWK91_11520	COG4836	Membrane
GWK91_11525	COG1007	ATP synthesis coupled electron transport
GWK91_11530	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GWK91_11535	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GWK91_11540	COG0713	ATP synthesis coupled electron transport
GWK91_11545	COG0839	Belongs to the complex I subunit 6 family
GWK91_11550	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GWK91_11555	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
GWK91_11560	COG0649	NAD binding
GWK91_11565	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GWK91_11570	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GWK91_11575	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GWK91_11580	COG0355	proton-transporting ATP synthase activity, rotational mechanism
GWK91_11585	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
GWK91_11595	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
GWK91_11600	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GWK91_11610	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GWK91_11615	COG0356	it plays a direct role in the translocation of protons across the membrane
GWK91_11630	COG1404	Belongs to the peptidase S8 family
GWK91_11635	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
GWK91_11640	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GWK91_11645	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GWK91_11650	COG4475	Protein of unknown function (DUF436)
GWK91_11655	COG0698	ribose 5-phosphate isomerase
GWK91_11660	COG0840	transmembrane signaling receptor activity
GWK91_11665	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GWK91_11670	COG1971	Probably functions as a manganese efflux pump
GWK91_11675	COG0009	L-threonylcarbamoyladenylate synthase
GWK91_11695	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GWK91_11700	COG1435	thymidine kinase activity
GWK91_11705	COG0254	rRNA binding
GWK91_11710	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
GWK91_11715	COG1494	fructose-1,6-bisphosphatase
GWK91_11725	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GWK91_11735	COG2204	response regulator
GWK91_11740	COG0504	CTP synthase activity
GWK91_11745	COG3343	RNA polymerase activity
GWK91_11750	COG2801	Transposase and inactivated derivatives
GWK91_11760	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GWK91_11760	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GWK91_11760	COG1703	isobutyryl-CoA mutase activity
GWK91_11770	COG1703	isobutyryl-CoA mutase activity
GWK91_11775	COG1960	acyl-CoA dehydrogenase activity
GWK91_11780	COG1960	acyl-CoA dehydrogenase activity
GWK91_11785	COG1250	3-hydroxyacyl-CoA dehydrogenase
GWK91_11790	COG0183	Belongs to the thiolase family
GWK91_11795	COG2181	nitrate reductase activity
GWK91_11795	COG0247	lactate metabolic process
GWK91_11800	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GWK91_11815	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GWK91_11830	COG3465	dGTPase activity
GWK91_11835	COG1078	dGTPase activity
GWK91_11840	COG0095	Lipoate-protein ligase
GWK91_11850	COG0280	phosphate acetyltransferase
GWK91_11860	COG3773	Cell wall hydrolase
GWK91_11875	COG2363	Small membrane protein
GWK91_11885	COG0765	amino acid transport
GWK91_11895	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GWK91_11900	COG1960	acyl-CoA dehydrogenase activity
GWK91_11905	COG1012	belongs to the aldehyde dehydrogenase family
GWK91_11925	COG2801	Transposase and inactivated derivatives
GWK91_11935	COG1012	belongs to the aldehyde dehydrogenase family
GWK91_11940	COG0028	Belongs to the TPP enzyme family
GWK91_11945	COG0436	Aminotransferase
GWK91_11950	COG1757	Na H antiporter
GWK91_11955	COG1757	Na H antiporter
GWK91_11985	COG1764	response to oxidative stress
GWK91_11990	COG3189	MarR family transcriptional regulator
GWK91_12000	COG0861	Integral membrane protein TerC family
GWK91_12005	COG1960	acyl-CoA dehydrogenase activity
GWK91_12010	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GWK91_12015	COG0765	amino acid transport
GWK91_12020	COG0765	amino acid transport
GWK91_12025	COG1126	abc transporter atp-binding protein
GWK91_12050	COG4637	Psort location Cytoplasmic, score
GWK91_12055	COG1472	Belongs to the glycosyl hydrolase 3 family
GWK91_12060	COG1607	acyl-coa hydrolase
GWK91_12065	COG1366	Belongs to the anti-sigma-factor antagonist family
GWK91_12070	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GWK91_12075	COG0156	8-amino-7-oxononanoate synthase activity
GWK91_12090	COG0723	plastoquinol--plastocyanin reductase activity
GWK91_12090	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GWK91_12095	COG2323	membrane
GWK91_12115	COG1278	Cold shock
GWK91_12125	COG1404	Belongs to the peptidase S8 family
GWK91_12130	COG2755	lipolytic protein G-D-S-L family
GWK91_12145	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GWK91_12150	COG2814	Major facilitator Superfamily
GWK91_12155	COG0154	amidase activity
GWK91_12175	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GWK91_12180	COG3973	AAA domain
GWK91_12190	COG4166	transmembrane transport
GWK91_12195	COG0179	Fumarylacetoacetate (FAA) hydrolase
GWK91_12200	COG1329	Transcriptional regulator
GWK91_12205	COG0006	proline dipeptidase activity
GWK91_12210	COG2423	ornithine cyclodeaminase activity
GWK91_12215	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
GWK91_12220	COG0534	Mate efflux family protein
GWK91_12225	COG1575	Belongs to the MenA family. Type 1 subfamily
GWK91_12250	COG0788	formyltetrahydrofolate deformylase activity
GWK91_12255	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GWK91_12255	COG0551	DNA topoisomerase type I activity
GWK91_12260	COG2814	Major facilitator Superfamily
GWK91_12265	COG2204	response regulator
GWK91_12270	COG3852	Histidine kinase
GWK91_12295	COG0456	acetyltransferase
GWK91_12300	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GWK91_12305	COG1917	Cupin 2, conserved barrel domain protein
GWK91_12315	COG4213	ABC transporter substrate-binding protein
GWK91_12325	COG1131	(ABC) transporter
GWK91_12335	COG4152	abc transporter atp-binding protein
GWK91_12340	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
GWK91_12345	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
GWK91_12360	COG2195	Cleaves the N-terminal amino acid of tripeptides
GWK91_12365	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GWK91_12370	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GWK91_12375	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GWK91_12380	COG0820	rRNA (adenine-C2-)-methyltransferase activity
GWK91_12385	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GWK91_12390	COG3104	oligopeptide transport
GWK91_12410	COG2814	Major facilitator Superfamily
GWK91_12440	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GWK91_12445	COG1266	CAAX protease self-immunity
GWK91_12455	COG1063	alcohol dehydrogenase
GWK91_12475	COG5002	protein histidine kinase activity
GWK91_12480	COG0745	RESPONSE REGULATOR receiver
GWK91_12485	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
GWK91_12490	COG0460	homoserine dehydrogenase
GWK91_12505	COG1404	Belongs to the peptidase S8 family
GWK91_12510	COG1114	Component of the transport system for branched-chain amino acids
GWK91_12530	COG1802	Transcriptional regulator
GWK91_12540	COG2610	gluconate transmembrane transporter activity
GWK91_12575	COG4536	flavin adenine dinucleotide binding
GWK91_12585	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GWK91_12590	COG0671	phosphoesterase, PA-phosphatase related
GWK91_12595	COG0579	oxidoreductase
GWK91_12600	COG0583	DNA-binding transcription factor activity
GWK91_12605	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
GWK91_12610	COG0154	amidase activity
GWK91_12630	COG1126	abc transporter atp-binding protein
GWK91_12635	COG0765	amino acid transport
GWK91_12640	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GWK91_12670	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
GWK91_12675	COG1522	sequence-specific DNA binding
GWK91_12680	COG1028	Short-chain dehydrogenase reductase Sdr
GWK91_12745	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
GWK91_12755	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
GWK91_12840	COG1368	sulfuric ester hydrolase activity
GWK91_12845	COG1028	Short-chain dehydrogenase reductase Sdr
GWK91_12865	COG1510	regulation of RNA biosynthetic process
GWK91_12870	COG3842	ATPase activity
GWK91_12885	COG0546	phosphoglycolate phosphatase activity
GWK91_12900	COG0783	Belongs to the Dps family
GWK91_12925	COG0673	inositol 2-dehydrogenase activity
GWK91_12930	COG3716	PTS system mannose fructose sorbose family IID component
GWK91_12935	COG3715	PTS system
GWK91_12955	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
GWK91_12960	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GWK91_12965	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
GWK91_12980	COG5002	protein histidine kinase activity
GWK91_12985	COG0745	RESPONSE REGULATOR receiver
GWK91_12990	COG0739	heme binding
GWK91_13010	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
GWK91_13030	COG0305	Participates in initiation and elongation during chromosome replication
GWK91_13035	COG0359	binds to the 23S rRNA
GWK91_13040	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
GWK91_13045	COG4241	membrane
GWK91_13050	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
GWK91_13055	COG0629	single-stranded DNA binding
GWK91_13060	COG0360	Binds together with S18 to 16S ribosomal RNA
GWK91_13065	COG0012	GTP binding
GWK91_13070	COG4481	Protein conserved in bacteria
GWK91_13075	COG3949	Membrane
GWK91_13090	COG1475	DNA binding
GWK91_13095	COG1192	Involved in chromosome partitioning
GWK91_13100	COG1475	DNA binding
GWK91_13105	COG0357	Ribosomal RNA small subunit methyltransferase G
GWK91_13110	COG0445	tRNA wobble uridine modification
GWK91_13115	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
GWK91_13120	COG1847	R3H domain protein
GWK91_13125	COG0706	membrane insertase activity
GWK91_13130	COG0594	ribonuclease P activity
GWK91_13135	COG0230	Belongs to the bacterial ribosomal protein bL34 family
GWK91_13140	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GWK91_13145	COG0592	DNA-directed DNA polymerase activity
GWK91_13150	COG2501	S4 domain
GWK91_13155	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GWK91_13165	COG0187	DNA topoisomerase II activity
GWK91_13170	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GWK91_13185	COG0516	GMP reductase activity
GWK91_13185	COG0517	IMP dehydrogenase activity
GWK91_13200	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
GWK91_13205	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GWK91_13215	COG1428	Deoxynucleoside kinase
GWK91_13220	COG1428	Deoxynucleoside kinase
GWK91_13225	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GWK91_13235	COG0561	phosphatase activity
GWK91_13240	COG0697	spore germination
GWK91_13260	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GWK91_13265	COG2233	PERMEase
GWK91_13275	COG3858	chitin binding
GWK91_13275	COG1388	LysM domain
GWK91_13290	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
GWK91_13295	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
GWK91_13300	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GWK91_13335	COG1982	Orn Lys Arg decarboxylase major
GWK91_13340	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GWK91_13345	COG3870	Protein conserved in bacteria
GWK91_13350	COG1728	Protein conserved in bacteria
GWK91_13355	COG0470	DNA polymerase III
GWK91_13360	COG1774	PSP1 C-terminal conserved region
GWK91_13365	COG4467	Involved in initiation control of chromosome replication
GWK91_13370	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
GWK91_13375	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
GWK91_13380	COG2002	toxin-antitoxin pair type II binding
GWK91_13390	COG0084	hydrolase, TatD family'
GWK91_13395	COG3584	3D domain protein
GWK91_13395	COG3583	domain protein
GWK91_13405	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GWK91_13415	COG4466	Protein conserved in bacteria
GWK91_13425	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
GWK91_13430	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GWK91_13435	COG2088	sporulation resulting in formation of a cellular spore
GWK91_13440	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GWK91_13445	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GWK91_13450	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
GWK91_13455	COG0193	aminoacyl-tRNA hydrolase activity
GWK91_13465	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
GWK91_13470	COG2002	toxin-antitoxin pair type II binding
GWK91_13475	COG2244	polysaccharide biosynthetic process
GWK91_13480	COG3956	TIGRFAM MazG family protein
GWK91_13485	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
GWK91_13500	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
GWK91_13505	COG1098	S1 RNA binding domain
GWK91_13520	COG2208	phosphoserine phosphatase activity
GWK91_13525	COG2304	oxidoreductase activity
GWK91_13530	COG0515	serine threonine protein kinase
GWK91_13535	COG0037	tRNA processing
GWK91_13545	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GWK91_13550	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
GWK91_13555	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GWK91_13560	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GWK91_13565	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GWK91_13570	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
GWK91_13575	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GWK91_13580	COG1396	sequence-specific DNA binding
GWK91_13585	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
GWK91_13665	COG1285	pathogenesis
GWK91_13675	COG3880	PFAM UvrB UvrC protein
GWK91_13680	COG3869	Catalyzes the specific phosphorylation of arginine residues in
GWK91_13685	COG0542	response to heat
GWK91_13690	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
GWK91_13695	COG4956	integral membrane protein (PIN domain superfamily)
GWK91_13700	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
GWK91_13700	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GWK91_13705	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GWK91_13710	COG1045	serine acetyltransferase
GWK91_13715	COG0215	cysteine-tRNA ligase activity
GWK91_13725	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GWK91_13730	COG3688	RNA-binding protein containing a PIN domain
GWK91_13740	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GWK91_13745	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GWK91_13750	COG0250	Participates in transcription elongation, termination and antitermination
GWK91_13760	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
GWK91_13765	COG0081	regulation of translation
GWK91_13770	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GWK91_13775	COG0222	ribosome binding
GWK91_13780	COG2813	Specifically methylates the guanine in position
GWK91_13785	COG0085	RNA polymerase activity
GWK91_13790	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GWK91_13795	COG1358	cellular component organization or biogenesis
GWK91_13800	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
GWK91_13805	COG0049	tRNA binding
GWK91_13810	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GWK91_13820	COG0051	transcription antitermination factor activity, RNA binding
GWK91_13825	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GWK91_13830	COG0088	Forms part of the polypeptide exit tunnel
GWK91_13835	COG0089	rRNA binding
GWK91_13840	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
GWK91_13845	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
GWK91_13850	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
GWK91_13855	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
GWK91_13860	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
GWK91_13865	COG0255	Belongs to the universal ribosomal protein uL29 family
GWK91_13875	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
GWK91_13885	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GWK91_13890	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GWK91_13895	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GWK91_13900	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
GWK91_13905	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
GWK91_13910	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
GWK91_13915	COG1841	ribosomal large subunit assembly
GWK91_13920	COG0200	Binds to the 23S rRNA
GWK91_13925	COG0201	protein transport
GWK91_13930	COG0563	adenylate kinase activity
GWK91_13935	COG2163	COG2163 Ribosomal protein L14E L6E L27E
GWK91_13940	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GWK91_13945	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GWK91_13950	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GWK91_13955	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GWK91_13960	COG0202	RNA polymerase activity
GWK91_13965	COG0203	ribosomal protein L17
GWK91_13970	COG1122	ATPase activity
GWK91_13975	COG1122	ATPase activity
GWK91_13985	COG0101	tRNA pseudouridine synthase activity
GWK91_13995	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GWK91_14000	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GWK91_14005	COG0860	N-Acetylmuramoyl-L-alanine amidase
GWK91_14010	COG0489	protein tyrosine kinase activity
GWK91_14020	COG2194	sulfuric ester hydrolase activity
GWK91_14025	COG0726	polysaccharide deacetylase
GWK91_14110	COG1595	DNA-templated transcription, initiation
GWK91_14115	COG5662	AntiSigma factor
GWK91_14120	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
GWK91_14125	COG4856	YbbR-like protein
GWK91_14130	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GWK91_14135	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GWK91_14155	COG2113	Glycine betaine
GWK91_14160	COG1309	transcriptional regulator
GWK91_14170	COG2814	Major facilitator Superfamily
GWK91_14185	COG0431	NADPH-dependent FMN reductase
GWK91_14195	COG1733	regulation of RNA biosynthetic process
GWK91_14215	COG2217	Heavy metal translocating P-type atpase
GWK91_14235	COG0432	Pfam Uncharacterised protein family UPF0047
GWK91_14240	COG2814	Major facilitator Superfamily
GWK91_14245	COG0477	Major facilitator Superfamily
GWK91_14250	COG1846	Transcriptional regulator
GWK91_14260	COG2514	catechol 2,3-dioxygenase activity
GWK91_14265	COG1929	Belongs to the glycerate kinase type-1 family
GWK91_14270	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GWK91_14275	COG1252	NADH dehydrogenase
GWK91_14290	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
GWK91_14310	COG0488	(ABC) transporter
GWK91_14320	COG0697	spore germination
GWK91_14340	COG0789	Transcriptional regulator
GWK91_14350	COG0745	RESPONSE REGULATOR receiver
GWK91_14355	COG5002	protein histidine kinase activity
GWK91_14355	COG3850	Histidine kinase
GWK91_14375	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GWK91_14380	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GWK91_14400	COG1380	Effector of murein hydrolase LrgA
GWK91_14405	COG1346	cytolysis
GWK91_14410	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
GWK91_14425	COG1227	inorganic diphosphatase activity
GWK91_14430	COG0561	phosphatase activity
GWK91_14440	COG5506	Protein of unknown function (DUF1694)
GWK91_14460	COG4585	Histidine kinase
GWK91_14465	COG2197	response regulator
GWK91_14480	COG0393	Putative heavy-metal-binding
GWK91_14485	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GWK91_14485	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GWK91_14490	COG0307	riboflavin synthase, alpha
GWK91_14495	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GWK91_14495	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GWK91_14500	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
GWK91_14505	COG0456	acetyltransferase
GWK91_14505	COG0454	-acetyltransferase
GWK91_14510	COG5577	PFAM Coat F domain
GWK91_14525	COG1278	Cold shock
GWK91_14530	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
GWK91_14535	COG2153	protein acetylation
GWK91_14540	COG2154	pterin-4-alpha-carbinolamine dehydratase
GWK91_14555	COG3584	3D domain protein
GWK91_14555	COG1388	LysM domain
GWK91_14575	COG1024	Enoyl-CoA hydratase
GWK91_14585	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GWK91_14590	COG3859	Proton-coupled thiamine transporter YuaJ
GWK91_14600	COG0129	dihydroxy-acid dehydratase activity
GWK91_14605	COG0028	Belongs to the TPP enzyme family
GWK91_14610	COG0440	acetolactate synthase activity
GWK91_14615	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
GWK91_14620	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GWK91_14625	COG0473	3-isopropylmalate dehydrogenase activity
GWK91_14630	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GWK91_14635	COG0066	3-isopropylmalate dehydratase activity
GWK91_14640	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
GWK91_14645	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
GWK91_14650	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GWK91_14655	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GWK91_14660	COG1120	ATPase activity
GWK91_14670	COG1619	proteins homologs of microcin C7 resistance protein MccF
GWK91_14675	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
GWK91_14680	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
GWK91_14690	COG0131	Imidazoleglycerol-phosphate dehydratase
GWK91_14695	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
GWK91_14700	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
GWK91_14705	COG0107	imidazoleglycerol-phosphate synthase activity
GWK91_14710	COG0140	phosphoribosyl-ATP diphosphatase activity
GWK91_14710	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
GWK91_14715	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GWK91_14745	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GWK91_14755	COG2258	MOSC domain
GWK91_14760	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GWK91_14775	COG1131	(ABC) transporter
GWK91_14815	COG0705	Rhomboid family
GWK91_14820	COG0736	holo-[acyl-carrier-protein] synthase activity
GWK91_14825	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
GWK91_14835	COG0864	Transcriptional regulator
GWK91_14840	COG2337	Toxic component of a toxin-antitoxin (TA) module
GWK91_14845	COG1366	Belongs to the anti-sigma-factor antagonist family
GWK91_14850	COG1366	Belongs to the anti-sigma-factor antagonist family
GWK91_14855	COG2172	sigma factor antagonist activity
GWK91_14860	COG2208	phosphoserine phosphatase activity
GWK91_14870	COG2172	sigma factor antagonist activity
GWK91_14875	COG1191	sigma factor activity
GWK91_14880	COG2208	phosphoserine phosphatase activity
GWK91_14885	COG2183	response to ionizing radiation
GWK91_14895	COG3091	SprT-like family
GWK91_14990	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
GWK91_14995	COG0802	atpase or kinase
GWK91_15000	COG1214	PFAM Peptidase M22, glycoprotease
GWK91_15005	COG0456	acetyltransferase
GWK91_15015	COG0488	(ABC) transporter
GWK91_15020	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
GWK91_15030	COG1266	CAAX protease self-immunity
GWK91_15035	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GWK91_15040	COG0459	protein refolding
GWK91_15045	COG0582	viral genome integration into host DNA
GWK91_15065	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
GWK91_15075	COG1309	transcriptional regulator
GWK91_15080	COG1393	Belongs to the ArsC family
GWK91_15085	COG1510	regulation of RNA biosynthetic process
GWK91_15100	COG2814	Major facilitator Superfamily
GWK91_15105	COG2801	Transposase and inactivated derivatives
GWK91_15115	COG1063	alcohol dehydrogenase
GWK91_15120	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GWK91_15130	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GWK91_15165	COG2304	oxidoreductase activity
GWK91_15220	COG4555	ABC transporter
GWK91_15250	COG0714	Associated with various cellular activities
GWK91_15255	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
GWK91_15260	COG1305	Transglutaminase-like
GWK91_15265	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GWK91_15265	COG0519	Catalyzes the synthesis of GMP from XMP
GWK91_15270	COG2252	PERMEase
GWK91_15285	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
GWK91_15295	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GWK91_15305	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
GWK91_15310	COG1470	cell adhesion involved in biofilm formation
GWK91_15315	COG4496	protein, YerC YecD
GWK91_15320	COG0423	glycine-tRNA ligase activity
GWK91_15325	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
GWK91_15330	COG0210	DNA helicase
GWK91_15335	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GWK91_15340	COG4851	CamS sex pheromone cAM373 precursor
GWK91_15345	COG1012	belongs to the aldehyde dehydrogenase family
GWK91_15350	COG1012	belongs to the aldehyde dehydrogenase family
GWK91_15355	COG0840	transmembrane signaling receptor activity
GWK91_15365	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
GWK91_15370	COG2224	Isocitrate lyase
GWK91_15375	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GWK91_15380	COG0154	amidase activity
GWK91_15385	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GWK91_15390	COG1597	lipid kinase activity
GWK91_15395	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GWK91_15410	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GWK91_15420	COG0745	RESPONSE REGULATOR receiver
GWK91_15425	COG5002	protein histidine kinase activity
GWK91_15440	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GWK91_15460	COG1595	DNA-templated transcription, initiation
GWK91_15480	COG1028	Short-chain dehydrogenase reductase Sdr
GWK91_15485	COG2814	Major facilitator Superfamily
GWK91_15490	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GWK91_15495	COG0010	Belongs to the arginase family
GWK91_15525	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GWK91_15545	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GWK91_15550	COG0673	inositol 2-dehydrogenase activity
GWK91_15565	COG1077	Cell shape determining protein MreB Mrl
GWK91_15590	COG2135	peptidase activity
GWK91_15595	COG1595	DNA-templated transcription, initiation
GWK91_15615	COG1115	amino acid carrier protein
GWK91_15620	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GWK91_15630	COG1295	ribonuclease BN
GWK91_15635	COG2217	Heavy metal translocating P-type atpase
GWK91_15640	COG0477	Major facilitator Superfamily
GWK91_15650	COG0668	transmembrane transport
GWK91_15655	COG2056	Na+-H+ antiporter family
GWK91_15660	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GWK91_15670	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
GWK91_15680	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
GWK91_15685	COG0561	phosphatase activity
GWK91_15690	COG1028	Short-chain dehydrogenase reductase Sdr
GWK91_15695	COG0109	protoheme IX farnesyltransferase activity
GWK91_15710	COG2259	Doxx family
GWK91_15715	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GWK91_15725	COG2409	Drug exporters of the RND superfamily
GWK91_15735	COG0785	Cytochrome C biogenesis protein
GWK91_15740	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GWK91_15765	COG1063	alcohol dehydrogenase
GWK91_15800	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GWK91_15810	COG1459	type II secretion system
GWK91_15820	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
GWK91_15840	COG2832	Protein of unknown function (DUF454)
GWK91_15850	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GWK91_15865	COG0667	Aldo Keto reductase
GWK91_15885	COG3764	Sortase (surface protein transpeptidase)
GWK91_15895	COG1131	(ABC) transporter
GWK91_15915	COG1388	LysM domain
GWK91_15915	COG3942	CHAP domain
GWK91_15930	COG2137	regulation of response to DNA damage stimulus
GWK91_15950	COG1988	membrane-bound metal-dependent
GWK91_15955	COG1194	a g-specific adenine glycosylase
GWK91_15965	COG3557	Belongs to the UPF0374 family
GWK91_15970	COG1132	(ABC) transporter
GWK91_15975	COG1525	nuclease
GWK91_15975	COG0737	Belongs to the 5'-nucleotidase family
GWK91_15975	COG4085	toxin activity
GWK91_15980	COG2353	YceI-like domain
GWK91_16000	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GWK91_16005	COG1595	DNA-templated transcription, initiation
GWK91_16015	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GWK91_16020	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GWK91_16020	COG0512	Glutamine amidotransferase of anthranilate synthase
GWK91_16025	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GWK91_16035	COG0135	phosphoribosylanthranilate isomerase activity
GWK91_16050	COG0475	glutathione-regulated potassium exporter activity
GWK91_16050	COG0569	domain protein
GWK91_16060	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GWK91_16065	COG0679	Auxin Efflux Carrier
GWK91_16085	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GWK91_16090	COG2096	Adenosyltransferase
GWK91_16095	COG0735	belongs to the Fur family
GWK91_16195	COG4974	Belongs to the 'phage' integrase family
GWK91_16240	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
GWK91_16295	COG0517	IMP dehydrogenase activity
GWK91_16295	COG4175	Glycine betaine
GWK91_16300	COG4176	ABC-type proline glycine betaine transport system permease component
GWK91_16350	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GWK91_16360	COG1785	Belongs to the alkaline phosphatase family
GWK91_16400	COG0681	Belongs to the peptidase S26 family
GWK91_16425	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
GWK91_16450	COG3588	fructose-bisphosphate aldolase
GWK91_16460	COG2304	oxidoreductase activity
GWK91_16475	COG1368	sulfuric ester hydrolase activity
GWK91_16485	COG1725	Transcriptional regulator
GWK91_16490	COG1131	(ABC) transporter
GWK91_16505	COG1595	DNA-templated transcription, initiation
GWK91_16510	COG2223	nitrite transmembrane transporter activity