locus-tag	class	description
KFZ58_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
KFZ58_00010	COG0592	DNA-directed DNA polymerase activity
KFZ58_00015	COG2501	S4 domain
KFZ58_00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
KFZ58_00030	COG0187	DNA topoisomerase II activity
KFZ58_00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
KFZ58_00050	COG0516	GMP reductase activity
KFZ58_00050	COG0517	IMP dehydrogenase activity
KFZ58_00060	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
KFZ58_00065	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
KFZ58_00070	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
KFZ58_00085	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
KFZ58_00105	COG1131	(ABC) transporter
KFZ58_00115	COG1428	Deoxynucleoside kinase
KFZ58_00120	COG1428	Deoxynucleoside kinase
KFZ58_00130	COG1301	dicarboxylic acid transport
KFZ58_00135	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
KFZ58_00145	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
KFZ58_00145	COG1017	nitric oxide dioxygenase activity
KFZ58_00150	COG1959	2 iron, 2 sulfur cluster binding
KFZ58_00155	COG0693	protein deglycase activity
KFZ58_00160	COG3858	chitin binding
KFZ58_00160	COG1388	LysM domain
KFZ58_00165	COG1335	isochorismatase
KFZ58_00170	COG0590	tRNA wobble adenosine to inosine editing
KFZ58_00195	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
KFZ58_00200	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
KFZ58_00205	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
KFZ58_00250	COG1547	Domain of unknown function (DUF309)
KFZ58_00260	COG1982	Orn Lys Arg decarboxylase major
KFZ58_00265	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
KFZ58_00270	COG3870	Protein conserved in bacteria
KFZ58_00275	COG1728	Protein conserved in bacteria
KFZ58_00280	COG0470	DNA polymerase III
KFZ58_00285	COG1774	PSP1 C-terminal conserved region
KFZ58_00290	COG4467	Involved in initiation control of chromosome replication
KFZ58_00295	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
KFZ58_00300	COG2827	Endonuclease containing a URI domain
KFZ58_00305	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
KFZ58_00315	COG1902	pentaerythritol trinitrate reductase activity
KFZ58_00330	COG2002	toxin-antitoxin pair type II binding
KFZ58_00340	COG0084	hydrolase, TatD family'
KFZ58_00345	COG3583	domain protein
KFZ58_00345	COG3584	3D domain protein
KFZ58_00355	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
KFZ58_00365	COG4466	Protein conserved in bacteria
KFZ58_00380	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
KFZ58_00385	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
KFZ58_00395	COG2323	membrane
KFZ58_00400	COG2088	sporulation resulting in formation of a cellular spore
KFZ58_00405	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
KFZ58_00410	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
KFZ58_00415	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
KFZ58_00420	COG0193	aminoacyl-tRNA hydrolase activity
KFZ58_00430	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
KFZ58_00435	COG2002	toxin-antitoxin pair type II binding
KFZ58_00460	COG2244	polysaccharide biosynthetic process
KFZ58_00465	COG3956	TIGRFAM MazG family protein
KFZ58_00470	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
KFZ58_00490	COG1098	S1 RNA binding domain
KFZ58_00500	COG2814	Major facilitator Superfamily
KFZ58_00510	COG2208	phosphoserine phosphatase activity
KFZ58_00515	COG2304	oxidoreductase activity
KFZ58_00520	COG0515	serine threonine protein kinase
KFZ58_00525	COG0037	tRNA processing
KFZ58_00530	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
KFZ58_00530	COG0037	tRNA processing
KFZ58_00535	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
KFZ58_00540	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
KFZ58_00545	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
KFZ58_00550	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
KFZ58_00555	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
KFZ58_00560	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
KFZ58_00565	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
KFZ58_00570	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
KFZ58_00575	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
KFZ58_00580	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
KFZ58_00660	COG1285	pathogenesis
KFZ58_00670	COG3880	PFAM UvrB UvrC protein
KFZ58_00675	COG3869	Catalyzes the specific phosphorylation of arginine residues in
KFZ58_00680	COG0542	response to heat
KFZ58_00685	COG3547	Transposase (IS116 IS110 IS902 family)
KFZ58_00690	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
KFZ58_00695	COG4956	integral membrane protein (PIN domain superfamily)
KFZ58_00700	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
KFZ58_00710	COG0215	cysteine-tRNA ligase activity
KFZ58_00720	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KFZ58_00725	COG3688	RNA-binding protein containing a PIN domain
KFZ58_00735	COG0267	Belongs to the bacterial ribosomal protein bL33 family
KFZ58_00740	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
KFZ58_00745	COG0250	Participates in transcription elongation, termination and antitermination
KFZ58_00750	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
KFZ58_00755	COG0081	regulation of translation
KFZ58_00760	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
KFZ58_00765	COG0222	ribosome binding
KFZ58_00770	COG2813	Specifically methylates the guanine in position
KFZ58_00775	COG0085	RNA polymerase activity
KFZ58_00780	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
KFZ58_00790	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
KFZ58_00795	COG0049	tRNA binding
KFZ58_00800	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
KFZ58_00810	COG0051	transcription antitermination factor activity, RNA binding
KFZ58_00815	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
KFZ58_00820	COG0088	Forms part of the polypeptide exit tunnel
KFZ58_00825	COG0089	rRNA binding
KFZ58_00830	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
KFZ58_00835	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
KFZ58_00840	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
KFZ58_00845	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
KFZ58_00850	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
KFZ58_00855	COG0255	Belongs to the universal ribosomal protein uL29 family
KFZ58_00860	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
KFZ58_00865	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
KFZ58_00870	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
KFZ58_00875	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
KFZ58_00880	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
KFZ58_00885	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
KFZ58_00890	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
KFZ58_00895	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
KFZ58_00900	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
KFZ58_00905	COG1841	ribosomal large subunit assembly
KFZ58_00910	COG0200	Binds to the 23S rRNA
KFZ58_00915	COG0201	protein transport
KFZ58_00920	COG0563	adenylate kinase activity
KFZ58_00925	COG2163	COG2163 Ribosomal protein L14E L6E L27E
KFZ58_00930	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
KFZ58_00935	COG0257	Belongs to the bacterial ribosomal protein bL36 family
KFZ58_00940	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
KFZ58_00945	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
KFZ58_00950	COG0202	RNA polymerase activity
KFZ58_00955	COG0203	ribosomal protein L17
KFZ58_00960	COG1122	ATPase activity
KFZ58_00965	COG1122	ATPase activity
KFZ58_00970	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
KFZ58_00975	COG0101	tRNA pseudouridine synthase activity
KFZ58_00980	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
KFZ58_00985	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
KFZ58_00990	COG1309	transcriptional regulator
KFZ58_00995	COG2814	Major facilitator Superfamily
KFZ58_01045	COG1295	ribonuclease BN
KFZ58_01070	COG0860	N-Acetylmuramoyl-L-alanine amidase
KFZ58_01075	COG0489	protein tyrosine kinase activity
KFZ58_01085	COG2194	sulfuric ester hydrolase activity
KFZ58_01090	COG0726	polysaccharide deacetylase
KFZ58_01145	COG2072	flavoprotein involved in K transport
KFZ58_01220	COG1595	DNA-templated transcription, initiation
KFZ58_01225	COG5662	AntiSigma factor
KFZ58_01230	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
KFZ58_01235	COG4856	YbbR-like protein
KFZ58_01240	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
KFZ58_01260	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
KFZ58_01265	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KFZ58_01270	COG1120	ATPase activity
KFZ58_01275	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
KFZ58_01280	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
KFZ58_01290	COG1492	cobalamin metabolic process
KFZ58_01295	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
KFZ58_01300	COG0588	phosphoglycerate mutase activity
KFZ58_01310	COG2096	Adenosyltransferase
KFZ58_01320	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
KFZ58_01330	COG1902	pentaerythritol trinitrate reductase activity
KFZ58_01335	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KFZ58_01340	COG3275	phosphorelay sensor kinase activity
KFZ58_01345	COG3279	Response regulator of the LytR AlgR family
KFZ58_01350	COG3162	membrane
KFZ58_01355	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KFZ58_01365	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
KFZ58_01375	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
KFZ58_01410	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KFZ58_01415	COG2259	Doxx family
KFZ58_01445	COG1388	LysM domain
KFZ58_01450	COG1937	Protein conserved in bacteria
KFZ58_01455	COG2217	Heavy metal translocating P-type atpase
KFZ58_01490	COG3177	Filamentation induced by cAMP protein fic
KFZ58_01500	COG0431	NADPH-dependent FMN reductase
KFZ58_01525	COG2814	Major facilitator Superfamily
KFZ58_01535	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
KFZ58_01540	COG1473	amidohydrolase
KFZ58_01550	COG1131	(ABC) transporter
KFZ58_01580	COG5504	Zn-dependent protease
KFZ58_01590	COG2226	methyltransferase
KFZ58_01600	COG0071	Belongs to the small heat shock protein (HSP20) family
KFZ58_01625	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
KFZ58_01630	COG1140	nitrate reductase beta subunit
KFZ58_01640	COG2181	nitrate reductase activity
KFZ58_01675	COG0783	Belongs to the Dps family
KFZ58_01735	COG0716	FMN binding
KFZ58_01740	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KFZ58_01745	COG3383	formate dehydrogenase (NAD+) activity
KFZ58_01755	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
KFZ58_01760	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
KFZ58_01765	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
KFZ58_01770	COG0303	'Molybdopterin
KFZ58_01775	COG0314	molybdopterin synthase activity
KFZ58_01785	COG1763	Mo-molybdopterin cofactor biosynthetic process
KFZ58_01790	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KFZ58_01795	COG0746	molybdenum cofactor guanylyltransferase activity
KFZ58_01800	COG0521	Mo-molybdopterin cofactor biosynthetic process
KFZ58_01805	COG0725	ABC transporter, periplasmic molybdate-binding protein
KFZ58_01810	COG4149	molybdate abc transporter
KFZ58_01815	COG1619	proteins homologs of microcin C7 resistance protein MccF
KFZ58_01840	COG0315	cyclic pyranopterin monophosphate synthase activity
KFZ58_01845	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KFZ58_01855	COG0745	RESPONSE REGULATOR receiver
KFZ58_01865	COG1136	(ABC) transporter
KFZ58_01870	COG0577	efflux transmembrane transporter activity
KFZ58_01880	COG0702	epimerase
KFZ58_01890	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KFZ58_01895	COG1271	oxidase subunit
KFZ58_01900	COG1294	oxidase, subunit
KFZ58_01905	COG4988	ABC transporter
KFZ58_01910	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
KFZ58_01915	COG2304	oxidoreductase activity
KFZ58_01925	COG3655	Transcriptional regulator
KFZ58_01930	COG1280	lysine exporter protein (LysE YggA)
KFZ58_01935	COG0436	Aminotransferase
KFZ58_01940	COG1114	Component of the transport system for branched-chain amino acids
KFZ58_01950	COG0564	pseudouridine synthase activity
KFZ58_01965	COG0204	Acyl-transferase
KFZ58_01975	COG1131	(ABC) transporter
KFZ58_01980	COG3559	Exporter of polyketide antibiotics
KFZ58_01990	COG1132	(ABC) transporter
KFZ58_01995	COG0604	alcohol dehydrogenase
KFZ58_02015	COG1131	(ABC) transporter
KFZ58_02020	COG2188	Transcriptional regulator
KFZ58_02030	COG0753	catalase activity
KFZ58_02045	COG1388	LysM domain
KFZ58_02045	COG3858	chitin binding
KFZ58_02055	COG2514	catechol 2,3-dioxygenase activity
KFZ58_02060	COG0400	carboxylic ester hydrolase activity
KFZ58_02065	COG1846	Transcriptional regulator
KFZ58_02070	COG0589	response to stress
KFZ58_02080	COG0667	Aldo Keto reductase
KFZ58_02085	COG2910	NAD(P)H-binding
KFZ58_02105	COG0488	(ABC) transporter
KFZ58_02110	COG2205	protein histidine kinase activity
KFZ58_02125	COG0745	RESPONSE REGULATOR receiver
KFZ58_02135	COG3173	Aminoglycoside phosphotransferase
KFZ58_02140	COG1607	acyl-coa hydrolase
KFZ58_02145	COG1473	amidohydrolase
KFZ58_02180	COG0596	Alpha beta hydrolase
KFZ58_02195	COG1704	LemA family
KFZ58_02200	COG0501	Belongs to the peptidase M48B family
KFZ58_02205	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
KFZ58_02210	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
KFZ58_02215	COG0083	homoserine kinase activity
KFZ58_02220	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
KFZ58_02225	COG0460	homoserine dehydrogenase
KFZ58_02240	COG2814	Major facilitator Superfamily
KFZ58_02245	COG1562	ergosterol biosynthetic process
KFZ58_02250	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
KFZ58_02255	COG1289	transmembrane transporter activity
KFZ58_02265	COG0789	Transcriptional regulator
KFZ58_02270	COG0352	thiamine-phosphate diphosphorylase activity
KFZ58_02275	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
KFZ58_02290	COG1063	alcohol dehydrogenase
KFZ58_02350	COG0662	Cupin 2, conserved barrel domain protein
KFZ58_02355	COG2856	Zn peptidase
KFZ58_02360	COG1396	sequence-specific DNA binding
KFZ58_02410	COG0433	COG0433 Predicted ATPase
KFZ58_02415	COG5644	endopeptidase inhibitor activity
KFZ58_02420	COG0741	lytic transglycosylase activity
KFZ58_02420	COG0791	NLP P60 protein
KFZ58_02470	COG4145	pantothenate transmembrane transporter activity
KFZ58_02475	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
KFZ58_02495	COG1131	(ABC) transporter
KFZ58_02505	COG5506	Protein of unknown function (DUF1694)
KFZ58_02520	COG5577	PFAM Coat F domain
KFZ58_02540	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KFZ58_02560	COG0697	spore germination
KFZ58_02585	COG0708	Exodeoxyribonuclease III
KFZ58_02590	COG1725	Transcriptional regulator
KFZ58_02595	COG1131	(ABC) transporter
KFZ58_02615	COG1215	transferase activity, transferring glycosyl groups
KFZ58_02625	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
KFZ58_02640	COG1028	Short-chain dehydrogenase reductase Sdr
KFZ58_02645	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KFZ58_02680	COG0673	inositol 2-dehydrogenase activity
KFZ58_02710	COG1288	antiporter activity
KFZ58_02715	COG1473	amidohydrolase
KFZ58_02740	COG0159	tryptophan synthase activity
KFZ58_02745	COG0133	tryptophan synthase activity
KFZ58_02755	COG0134	indole-3-glycerol-phosphate synthase activity
KFZ58_02760	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
KFZ58_02765	COG0512	Glutamine amidotransferase of anthranilate synthase
KFZ58_02770	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
KFZ58_02775	COG1181	Belongs to the D-alanine--D-alanine ligase family
KFZ58_02780	COG0778	Nitroreductase
KFZ58_02800	COG1418	mRNA catabolic process
KFZ58_02810	COG1876	peptidase activity
KFZ58_02815	COG2195	Cleaves the N-terminal amino acid of tripeptides
KFZ58_02820	COG2897	thiosulfate sulfurtransferase activity
KFZ58_02825	COG0519	Catalyzes the synthesis of GMP from XMP
KFZ58_02880	COG0814	amino acid
KFZ58_02885	COG0697	spore germination
KFZ58_02900	COG1304	FMN binding
KFZ58_02905	COG4876	unkown
KFZ58_02910	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KFZ58_02915	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
KFZ58_02920	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KFZ58_02925	COG4605	iron ion homeostasis
KFZ58_02930	COG4604	ABC transporter, ATP-binding protein
KFZ58_02935	COG4607	ABC-type enterochelin transport system periplasmic component
KFZ58_02945	COG0583	DNA-binding transcription factor activity
KFZ58_02950	COG0070	glutamate synthase
KFZ58_02950	COG0069	glutamate synthase activity
KFZ58_02950	COG0067	glutamate synthase
KFZ58_02955	COG0493	'glutamate synthase
KFZ58_02960	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
KFZ58_02965	COG0140	phosphoribosyl-ATP diphosphatase activity
KFZ58_02965	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
KFZ58_02970	COG0107	imidazoleglycerol-phosphate synthase activity
KFZ58_02975	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
KFZ58_02980	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
KFZ58_02985	COG0131	Imidazoleglycerol-phosphate dehydratase
KFZ58_02990	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
KFZ58_02995	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
KFZ58_03000	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
KFZ58_03015	COG0812	UDP-N-acetylmuramate dehydrogenase activity
KFZ58_03020	COG1126	abc transporter atp-binding protein
KFZ58_03025	COG0765	amino acid transport
KFZ58_03030	COG0765	amino acid transport
KFZ58_03045	COG0673	inositol 2-dehydrogenase activity
KFZ58_03050	COG0463	Glycosyl transferase, family 2
KFZ58_03060	COG4485	Bacterial membrane protein, YfhO
KFZ58_03070	COG0346	lactoylglutathione lyase activity
KFZ58_03075	COG1876	peptidase activity
KFZ58_03080	COG1904	glucuronate isomerase
KFZ58_03085	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
KFZ58_03095	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
KFZ58_03100	COG1803	Methylglyoxal synthase
KFZ58_03105	COG0673	inositol 2-dehydrogenase activity
KFZ58_03110	COG0673	inositol 2-dehydrogenase activity
KFZ58_03115	COG1082	Xylose isomerase domain protein TIM barrel
KFZ58_03125	COG1802	Transcriptional regulator
KFZ58_03130	COG1063	alcohol dehydrogenase
KFZ58_03165	COG0656	L-ascorbic acid biosynthetic process
KFZ58_03185	COG1691	(AIR) carboxylase
KFZ58_03190	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
KFZ58_03210	COG3250	beta-galactosidase activity
KFZ58_03220	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
KFZ58_03235	COG3250	beta-galactosidase activity
KFZ58_03240	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
KFZ58_03240	COG2207	Transcriptional regulator
KFZ58_03245	COG2211	Major facilitator Superfamily
KFZ58_03250	COG0831	urea catabolic process
KFZ58_03255	COG0832	Belongs to the urease beta subunit family
KFZ58_03265	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
KFZ58_03270	COG0830	nickel cation binding
KFZ58_03275	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
KFZ58_03280	COG0829	nickel cation binding
KFZ58_03295	COG0601	transmembrane transport
KFZ58_03315	COG2839	Protein conserved in bacteria
KFZ58_03320	COG0351	phosphomethylpyrimidine kinase
KFZ58_03330	COG1335	isochorismatase
KFZ58_03340	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
KFZ58_03345	COG0386	Belongs to the glutathione peroxidase family
KFZ58_03350	COG1054	Belongs to the UPF0176 family
KFZ58_03355	COG1278	Cold shock
KFZ58_03370	COG2084	Dehydrogenase
KFZ58_03375	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
KFZ58_03380	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KFZ58_03385	COG0745	RESPONSE REGULATOR receiver
KFZ58_03390	COG3850	Histidine kinase
KFZ58_03390	COG5002	protein histidine kinase activity
KFZ58_03395	COG1217	gtp-binding protein TYPA
KFZ58_03405	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KFZ58_03405	COG1263	PTS System
KFZ58_03410	COG0366	Alpha amylase catalytic
KFZ58_03415	COG2188	Transcriptional regulator
KFZ58_03430	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
KFZ58_03435	COG1131	(ABC) transporter
KFZ58_03455	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KFZ58_03470	COG0745	RESPONSE REGULATOR receiver
KFZ58_03475	COG3850	Histidine kinase
KFZ58_03475	COG5002	protein histidine kinase activity
KFZ58_03480	COG3212	peptidase
KFZ58_03485	COG1597	lipid kinase activity
KFZ58_03495	COG2894	cell division
KFZ58_03520	COG2304	oxidoreductase activity
KFZ58_03580	COG1307	EDD domain protein, DegV family
KFZ58_03590	COG0513	Belongs to the DEAD box helicase family
KFZ58_03595	COG3402	PFAM membrane-flanked domain
KFZ58_03600	COG3428	Bacterial PH domain
KFZ58_03605	COG0705	Rhomboid family
KFZ58_03610	COG0736	holo-[acyl-carrier-protein] synthase activity
KFZ58_03615	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
KFZ58_03615	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
KFZ58_03620	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
KFZ58_03625	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
KFZ58_03635	COG2337	Toxic component of a toxin-antitoxin (TA) module
KFZ58_03640	COG1366	Belongs to the anti-sigma-factor antagonist family
KFZ58_03645	COG1366	Belongs to the anti-sigma-factor antagonist family
KFZ58_03650	COG2172	sigma factor antagonist activity
KFZ58_03655	COG2208	phosphoserine phosphatase activity
KFZ58_03660	COG1366	Belongs to the anti-sigma-factor antagonist family
KFZ58_03665	COG2172	sigma factor antagonist activity
KFZ58_03670	COG1191	sigma factor activity
KFZ58_03675	COG2208	phosphoserine phosphatase activity
KFZ58_03685	COG2183	response to ionizing radiation
KFZ58_03755	COG0753	catalase activity
KFZ58_03760	COG3091	SprT-like family
KFZ58_03860	COG0582	viral genome integration into host DNA
KFZ58_03870	COG1396	sequence-specific DNA binding
KFZ58_03885	COG1674	ftsk spoiiie
KFZ58_03890	COG2946	Replication initiation factor
KFZ58_03930	COG0433	COG0433 Predicted ATPase
KFZ58_03935	COG5644	endopeptidase inhibitor activity
KFZ58_03940	COG0791	NLP P60 protein
KFZ58_03940	COG0741	lytic transglycosylase activity
KFZ58_03965	COG0456	acetyltransferase
KFZ58_03965	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
KFZ58_04035	COG0384	phenazine biosynthesis protein PhzF
KFZ58_04040	COG1247	-acetyltransferase
KFZ58_04090	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
KFZ58_04095	COG0802	atpase or kinase
KFZ58_04100	COG1214	PFAM Peptidase M22, glycoprotease
KFZ58_04105	COG0456	acetyltransferase
KFZ58_04110	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
KFZ58_04115	COG0772	Belongs to the SEDS family
KFZ58_04120	COG1253	flavin adenine dinucleotide binding
KFZ58_04125	COG0488	(ABC) transporter
KFZ58_04130	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
KFZ58_04140	COG1266	CAAX protease self-immunity
KFZ58_04145	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
KFZ58_04150	COG0459	protein refolding
KFZ58_04165	COG1937	Protein conserved in bacteria
KFZ58_04170	COG2217	Heavy metal translocating P-type atpase
KFZ58_04180	COG2226	methyltransferase
KFZ58_04190	COG5002	protein histidine kinase activity
KFZ58_04195	COG0745	RESPONSE REGULATOR receiver
KFZ58_04205	COG2132	Multicopper oxidase
KFZ58_04220	COG0785	Cytochrome C biogenesis protein
KFZ58_04230	COG1388	LysM domain
KFZ58_04240	COG3328	transposase activity
KFZ58_04290	COG0640	Transcriptional regulator
KFZ58_04310	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
KFZ58_04320	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
KFZ58_04345	COG0640	Transcriptional regulator
KFZ58_04355	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
KFZ58_04360	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
KFZ58_04375	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
KFZ58_04400	COG0753	catalase activity
KFZ58_04405	COG0745	RESPONSE REGULATOR receiver
KFZ58_04410	COG0642	Histidine kinase
KFZ58_04415	COG1136	(ABC) transporter
KFZ58_04420	COG0577	efflux transmembrane transporter activity
KFZ58_04445	COG0791	NLP P60 protein
KFZ58_04455	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
KFZ58_04475	COG3773	Cell wall hydrolase
KFZ58_04480	COG1846	Transcriptional regulator
KFZ58_04485	COG2814	Major facilitator Superfamily
KFZ58_04490	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
KFZ58_04495	COG1522	sequence-specific DNA binding
KFZ58_04500	COG1522	sequence-specific DNA binding
KFZ58_04510	COG1335	isochorismatase
KFZ58_04515	COG0730	response to heat
KFZ58_04520	COG0583	DNA-binding transcription factor activity
KFZ58_04525	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
KFZ58_04535	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KFZ58_04540	COG1937	Protein conserved in bacteria
KFZ58_04555	COG1288	antiporter activity
KFZ58_04560	COG3290	protein histidine kinase activity
KFZ58_04565	COG4565	transcriptional regulatory protein
KFZ58_04570	COG2851	Citrate transporter
KFZ58_04575	COG2860	membrane
KFZ58_04590	COG3361	conserved protein (COG2071)
KFZ58_04595	COG0697	spore germination
KFZ58_04600	COG0390	transport system, permease component
KFZ58_04605	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
KFZ58_04615	COG0628	permease
KFZ58_04630	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KFZ58_04635	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KFZ58_04640	COG0601	transmembrane transport
KFZ58_04650	COG4608	Belongs to the ABC transporter superfamily
KFZ58_04655	COG0444	Belongs to the ABC transporter superfamily
KFZ58_04680	COG0697	spore germination
KFZ58_04685	COG0531	amino acid
KFZ58_04695	COG0154	amidase activity
KFZ58_04705	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
KFZ58_04710	COG0714	Associated with various cellular activities
KFZ58_04715	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
KFZ58_04720	COG1305	Transglutaminase-like
KFZ58_04725	COG0518	GMP synthase (glutamine-hydrolyzing) activity
KFZ58_04725	COG0519	Catalyzes the synthesis of GMP from XMP
KFZ58_04735	COG2252	PERMEase
KFZ58_04745	COG0546	phosphoglycolate phosphatase activity
KFZ58_04750	COG0456	acetyltransferase
KFZ58_04760	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
KFZ58_04765	COG2814	Major facilitator Superfamily
KFZ58_04770	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
KFZ58_04780	COG2258	MOSC domain
KFZ58_04795	COG0681	Belongs to the peptidase S26 family
KFZ58_04805	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
KFZ58_04810	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
KFZ58_04815	COG0656	L-ascorbic acid biosynthetic process
KFZ58_04820	COG1028	Short-chain dehydrogenase reductase Sdr
KFZ58_04825	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
KFZ58_04830	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
KFZ58_04835	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
KFZ58_04840	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
KFZ58_04845	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
KFZ58_04850	COG0047	phosphoribosylformylglycinamidine synthase activity
KFZ58_04855	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
KFZ58_04860	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
KFZ58_04870	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
KFZ58_04880	COG0151	Belongs to the GarS family
KFZ58_04890	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
KFZ58_04895	COG1470	cell adhesion involved in biofilm formation
KFZ58_04900	COG4496	protein, YerC YecD
KFZ58_04905	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
KFZ58_04910	COG0210	DNA helicase
KFZ58_04915	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
KFZ58_04920	COG4851	CamS sex pheromone cAM373 precursor
KFZ58_04935	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
KFZ58_04940	COG0154	amidase activity
KFZ58_04945	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
KFZ58_04950	COG1597	lipid kinase activity
KFZ58_04955	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
KFZ58_04960	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
KFZ58_04965	COG0109	protoheme IX farnesyltransferase activity
KFZ58_04975	COG0166	Belongs to the GPI family
KFZ58_04980	COG0564	pseudouridine synthase activity
KFZ58_04985	COG0328	RNA-DNA hybrid ribonuclease activity
KFZ58_05000	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
KFZ58_05000	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
KFZ58_05005	COG0307	riboflavin synthase, alpha
KFZ58_05015	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
KFZ58_05020	COG0488	(ABC) transporter
KFZ58_05040	COG0446	pyridine nucleotide-disulphide oxidoreductase
KFZ58_05045	COG0733	neurotransmitter:sodium symporter activity
KFZ58_05060	COG3844	kynureninase activity
KFZ58_05065	COG0436	Aminotransferase
KFZ58_05070	COG0028	Belongs to the TPP enzyme family
KFZ58_05075	COG1012	belongs to the aldehyde dehydrogenase family
KFZ58_05085	COG1414	Transcriptional regulator
KFZ58_05095	COG1012	belongs to the aldehyde dehydrogenase family
KFZ58_05105	COG1804	L-carnitine dehydratase bile acid-inducible protein F
KFZ58_05110	COG1077	Cell shape determining protein MreB Mrl
KFZ58_05115	COG2340	Cysteine-rich secretory protein family
KFZ58_05120	COG2066	Belongs to the glutaminase family
KFZ58_05125	COG2135	peptidase activity
KFZ58_05135	COG1295	ribonuclease BN
KFZ58_05140	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KFZ58_05145	COG0765	amino acid transport
KFZ58_05150	COG0477	Major facilitator Superfamily
KFZ58_05165	COG2056	Na+-H+ antiporter family
KFZ58_05175	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
KFZ58_05180	COG0542	response to heat
KFZ58_05185	COG0658	competence protein
KFZ58_05185	COG2333	competence protein COMEC
KFZ58_05200	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
KFZ58_05205	COG1131	(ABC) transporter
KFZ58_05215	COG1396	sequence-specific DNA binding
KFZ58_05225	COG1090	epimerase
KFZ58_05230	COG2137	regulation of response to DNA damage stimulus
KFZ58_05240	COG1988	membrane-bound metal-dependent
KFZ58_05245	COG1194	a g-specific adenine glycosylase
KFZ58_05255	COG3557	Belongs to the UPF0374 family
KFZ58_05260	COG1132	(ABC) transporter
KFZ58_05265	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
KFZ58_05275	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
KFZ58_05290	COG0735	belongs to the Fur family
KFZ58_05390	COG2364	Membrane
KFZ58_05405	COG0659	secondary active sulfate transmembrane transporter activity
KFZ58_05415	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KFZ58_05430	COG1227	inorganic diphosphatase activity
KFZ58_05440	COG4948	Mandelate Racemase Muconate Lactonizing
KFZ58_05450	COG1970	mechanosensitive ion channel activity
KFZ58_05470	COG4474	Belongs to the UPF0398 family
KFZ58_05480	COG1131	(ABC) transporter
KFZ58_05510	COG1247	-acetyltransferase
KFZ58_05520	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KFZ58_05570	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KFZ58_05575	COG0765	amino acid transport
KFZ58_05580	COG1126	abc transporter atp-binding protein
KFZ58_05585	COG2814	Major facilitator Superfamily
KFZ58_05590	COG0367	asparagine synthase
KFZ58_05605	COG1174	glycine betaine transport
KFZ58_05615	COG0346	lactoylglutathione lyase activity
KFZ58_05620	COG0667	Aldo Keto reductase
KFZ58_05630	COG0288	reversible hydration of carbon dioxide
KFZ58_05635	COG0791	NLP P60 protein
KFZ58_05635	COG1388	LysM domain
KFZ58_05635	COG3103	Sh3 type 3 domain protein
KFZ58_05640	COG1408	metallophosphoesterase
KFZ58_05655	COG0737	Belongs to the 5'-nucleotidase family
KFZ58_05660	COG3764	Sortase (surface protein transpeptidase)
KFZ58_05690	COG1329	Transcriptional regulator
KFZ58_05695	COG1393	Belongs to the ArsC family
KFZ58_05705	COG3584	3D domain protein
KFZ58_05705	COG1388	LysM domain
KFZ58_05720	COG1011	Hydrolase
KFZ58_05730	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
KFZ58_05765	COG3732	PTS system glucitol sorbitol-specific
KFZ58_05780	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
KFZ58_05785	COG3414	Phosphotransferase system galactitol-specific IIB component
KFZ58_05790	COG3775	system Galactitol-specific IIC component
KFZ58_05795	COG1063	alcohol dehydrogenase
KFZ58_05800	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
KFZ58_05810	COG1063	alcohol dehydrogenase
KFZ58_05820	COG0165	Argininosuccinate lyase
KFZ58_05825	COG1940	carbohydrate kinase activity
KFZ58_05840	COG0395	ABC-type sugar transport system, permease component
KFZ58_05850	COG1802	Transcriptional regulator
KFZ58_05855	COG0473	3-isopropylmalate dehydrogenase activity
KFZ58_05860	COG3493	citrate carrier protein
KFZ58_05865	COG1929	Belongs to the glycerate kinase type-1 family
KFZ58_05870	COG4948	Mandelate Racemase Muconate Lactonizing
KFZ58_05885	COG1304	FMN binding
KFZ58_05920	COG1250	3-hydroxyacyl-CoA dehydrogenase
KFZ58_05925	COG2610	gluconate transmembrane transporter activity
KFZ58_05940	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
KFZ58_05945	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
KFZ58_05950	COG2376	Dihydroxyacetone kinase
KFZ58_05955	COG1461	Dihydroxyacetone kinase
KFZ58_05960	COG2084	Dehydrogenase
KFZ58_05965	COG2376	Dihydroxyacetone kinase
KFZ58_05980	COG1349	DNA-binding transcription factor activity
KFZ58_05985	COG0698	ribose 5-phosphate isomerase
KFZ58_05990	COG1494	fructose-1,6-bisphosphatase
KFZ58_05995	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
KFZ58_06005	COG3191	aminopeptidase activity
KFZ58_06015	COG2186	Transcriptional regulator
KFZ58_06025	COG4145	pantothenate transmembrane transporter activity
KFZ58_06035	COG0473	3-isopropylmalate dehydrogenase activity
KFZ58_06040	COG1028	Short-chain dehydrogenase reductase Sdr
KFZ58_06045	COG1012	belongs to the aldehyde dehydrogenase family
KFZ58_06060	COG0493	'glutamate synthase
KFZ58_06065	COG0167	dihydroorotate dehydrogenase activity
KFZ58_06065	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
KFZ58_06095	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KFZ58_06130	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
KFZ58_06135	COG0686	Belongs to the AlaDH PNT family
KFZ58_06140	COG1012	belongs to the aldehyde dehydrogenase family
KFZ58_06145	COG0583	DNA-binding transcription factor activity
KFZ58_06150	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
KFZ58_06155	COG0277	FAD linked oxidase domain protein
KFZ58_06160	COG0247	lactate metabolic process
KFZ58_06165	COG0277	FAD linked oxidase domain protein
KFZ58_06170	COG0179	Fumarylacetoacetate (FAA) hydrolase
KFZ58_06175	COG1620	l-lactate permease
KFZ58_06180	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
KFZ58_06200	COG0626	cystathionine gamma-synthase activity
KFZ58_06205	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
KFZ58_06210	COG1606	tRNA processing
KFZ58_06215	COG0006	proline dipeptidase activity
KFZ58_06225	COG1802	Transcriptional regulator
KFZ58_06235	COG1012	belongs to the aldehyde dehydrogenase family
KFZ58_06240	COG0251	oxidation-reduction process
KFZ58_06245	COG1473	amidohydrolase
KFZ58_06250	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
KFZ58_06265	COG0473	3-isopropylmalate dehydrogenase activity
KFZ58_06285	COG0616	signal peptide processing
KFZ58_06290	COG1714	RDD family
KFZ58_06300	COG0318	PFAM AMP-dependent synthetase and ligase
KFZ58_06315	COG0702	epimerase
KFZ58_06320	COG0653	protein targeting
KFZ58_06325	COG0653	protein targeting
KFZ58_06380	COG0110	maltose O-acetyltransferase activity
KFZ58_06390	COG4585	Histidine kinase
KFZ58_06395	COG2197	response regulator
KFZ58_06400	COG1131	(ABC) transporter
KFZ58_06425	COG0438	transferase activity, transferring glycosyl groups
KFZ58_06435	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
KFZ58_06440	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
KFZ58_06445	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
KFZ58_06450	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
KFZ58_06455	COG0505	Belongs to the CarA family
KFZ58_06460	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
KFZ58_06465	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
KFZ58_06470	COG0137	argininosuccinate synthase activity
KFZ58_06475	COG0165	Argininosuccinate lyase
KFZ58_06480	COG0823	Involved in the tonB-independent uptake of proteins
KFZ58_06480	COG1506	peptidase
KFZ58_06480	COG4946	Tricorn protease homolog
KFZ58_06490	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KFZ58_06515	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
KFZ58_06520	COG0567	Dehydrogenase, E1 component
KFZ58_06525	COG0508	dehydrogenase complex catalyzes the overall conversion of
KFZ58_06535	COG2252	PERMEase
KFZ58_06540	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
KFZ58_06550	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
KFZ58_06565	COG3448	diguanylate cyclase activity
KFZ58_06565	COG4175	Glycine betaine
KFZ58_06580	COG0697	spore germination
KFZ58_06600	COG1191	sigma factor activity
KFZ58_06620	COG2226	methyltransferase
KFZ58_06625	COG1854	S-ribosylhomocysteine lyase activity
KFZ58_06630	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
KFZ58_06635	COG0626	cystathionine gamma-synthase activity
KFZ58_06640	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KFZ58_06645	COG1028	Short-chain dehydrogenase reductase Sdr
KFZ58_06660	COG1131	(ABC) transporter
KFZ58_06665	COG0024	Methionine aminopeptidase
KFZ58_06670	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
KFZ58_06675	COG1757	Na H antiporter
KFZ58_06680	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
KFZ58_06690	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
KFZ58_06700	COG0114	fumarate hydratase activity
KFZ58_06710	COG3842	ATPase activity
KFZ58_06715	COG2508	Transcriptional regulator
KFZ58_06720	COG3679	Belongs to the UPF0342 family
KFZ58_06725	COG1024	Enoyl-CoA hydratase
KFZ58_06735	COG4152	abc transporter atp-binding protein
KFZ58_06740	COG1668	transmembrane transport
KFZ58_06745	COG0420	3'-5' exonuclease activity
KFZ58_06750	COG4717	serine-type aminopeptidase activity
KFZ58_06755	COG1510	regulation of RNA biosynthetic process
KFZ58_06760	COG3481	metal-dependent phosphohydrolase, HD sub domain
KFZ58_06770	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
KFZ58_06795	COG1510	regulation of RNA biosynthetic process
KFZ58_06800	COG4175	Glycine betaine
KFZ58_06800	COG0517	IMP dehydrogenase activity
KFZ58_06810	COG2113	Glycine betaine
KFZ58_06820	COG0537	adenosine 5'-monophosphoramidase activity
KFZ58_06825	COG1131	(ABC) transporter
KFZ58_06830	COG4473	ABC transporter
KFZ58_06835	COG1473	amidohydrolase
KFZ58_06840	COG2193	ferroxidase activity
KFZ58_06845	COG0671	phosphoesterase, PA-phosphatase related
KFZ58_06850	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
KFZ58_06865	COG2329	Antibiotic biosynthesis monooxygenase
KFZ58_06875	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
KFZ58_06880	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
KFZ58_06885	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
KFZ58_06890	COG1164	Oligoendopeptidase f
KFZ58_06900	COG1234	tRNA 3'-trailer cleavage
KFZ58_06905	COG0095	Lipoate-protein ligase
KFZ58_06920	COG0398	Pfam SNARE associated Golgi protein
KFZ58_06930	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
KFZ58_06935	COG1074	ATP-dependent DNA helicase activity
KFZ58_06945	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
KFZ58_06950	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
KFZ58_06985	COG1307	EDD domain protein, DegV family
KFZ58_06990	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KFZ58_07010	COG0561	phosphatase activity
KFZ58_07015	COG1073	alpha beta
KFZ58_07020	COG2151	metal-sulfur cluster biosynthetic enzyme
KFZ58_07025	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KFZ58_07035	COG0535	radical SAM domain protein
KFZ58_07040	COG1968	undecaprenyl-diphosphatase activity
KFZ58_07060	COG1744	ABC transporter substrate-binding protein PnrA-like
KFZ58_07065	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KFZ58_07070	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
KFZ58_07085	COG0180	Tryptophanyl-tRNA synthetase
KFZ58_07105	COG0004	ammonium transporteR
KFZ58_07110	COG0347	Belongs to the P(II) protein family
KFZ58_07115	COG1393	Belongs to the ArsC family
KFZ58_07120	COG4862	establishment of competence for transformation
KFZ58_07130	COG1164	Oligoendopeptidase f
KFZ58_07140	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
KFZ58_07145	COG2346	COG2346, Truncated hemoglobins
KFZ58_07150	COG4116	CYTH
KFZ58_07155	COG2357	RelA SpoT domain protein
KFZ58_07160	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
KFZ58_07165	COG0564	pseudouridine synthase activity
KFZ58_07170	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
KFZ58_07175	COG2239	Acts as a magnesium transporter
KFZ58_07200	COG2323	membrane
KFZ58_07205	COG2153	protein acetylation
KFZ58_07210	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
KFZ58_07215	COG2382	esterase
KFZ58_07220	COG1132	(ABC) transporter
KFZ58_07225	COG1132	(ABC) transporter
KFZ58_07235	COG1028	Short-chain dehydrogenase reductase Sdr
KFZ58_07255	COG3588	fructose-bisphosphate aldolase
KFZ58_07260	COG1131	(ABC) transporter
KFZ58_07275	COG4585	Histidine kinase
KFZ58_07285	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KFZ58_07290	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
KFZ58_07295	COG2258	MOSC domain
KFZ58_07300	COG3290	protein histidine kinase activity
KFZ58_07305	COG4565	transcriptional regulatory protein
KFZ58_07310	COG3181	Tripartite tricarboxylate transporter family receptor
KFZ58_07330	COG4187	Peptidase family M20/M25/M40
KFZ58_07335	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KFZ58_07340	COG4548	von Willebrand factor, type A
KFZ58_07345	COG0714	Associated with various cellular activities
KFZ58_07350	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KFZ58_07360	COG1733	regulation of RNA biosynthetic process
KFZ58_07370	COG0431	NADPH-dependent FMN reductase
KFZ58_07380	COG0561	phosphatase activity
KFZ58_07405	COG1098	S1 RNA binding domain
KFZ58_07415	COG2391	methyltransferase activity
KFZ58_07420	COG3425	synthase
KFZ58_07430	COG3829	transcription factor binding
KFZ58_07430	COG3290	protein histidine kinase activity
KFZ58_07435	COG1012	belongs to the aldehyde dehydrogenase family
KFZ58_07440	COG0506	proline dehydrogenase activity
KFZ58_07445	COG1615	UPF0182 protein
KFZ58_07450	COG0431	NADPH-dependent FMN reductase
KFZ58_07460	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
KFZ58_07495	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
KFZ58_07500	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
KFZ58_07505	COG0517	IMP dehydrogenase activity
KFZ58_07510	COG2323	membrane
KFZ58_07515	COG0753	catalase activity
KFZ58_07530	COG0473	3-isopropylmalate dehydrogenase activity
KFZ58_07540	COG1804	L-carnitine dehydratase bile acid-inducible protein F
KFZ58_07565	COG1917	Cupin 2, conserved barrel domain protein
KFZ58_07570	COG0626	cystathionine gamma-synthase activity
KFZ58_07580	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
KFZ58_07590	COG0175	sulfate reduction
KFZ58_07595	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
KFZ58_07600	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
KFZ58_07625	COG2046	Belongs to the sulfate adenylyltransferase family
KFZ58_07635	COG0529	Catalyzes the synthesis of activated sulfate
KFZ58_07660	COG0367	asparagine synthase
KFZ58_07670	COG0277	FAD linked oxidase domain protein
KFZ58_07675	COG1404	Belongs to the peptidase S8 family
KFZ58_07685	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
KFZ58_07690	COG2027	D-alanyl-D-alanine carboxypeptidase
KFZ58_07695	COG0753	catalase activity
KFZ58_07700	COG0154	amidase activity
KFZ58_07725	COG0745	RESPONSE REGULATOR receiver
KFZ58_07730	COG2205	protein histidine kinase activity
KFZ58_07735	COG1136	(ABC) transporter
KFZ58_07740	COG0577	efflux transmembrane transporter activity
KFZ58_07765	COG0142	geranyltranstransferase activity
KFZ58_07775	COG4978	Transcriptional regulator
KFZ58_07775	COG0789	Transcriptional regulator
KFZ58_07780	COG0716	FMN binding
KFZ58_07785	COG2329	Antibiotic biosynthesis monooxygenase
KFZ58_07795	COG3829	transcription factor binding
KFZ58_07795	COG3290	protein histidine kinase activity
KFZ58_07800	COG4948	Mandelate Racemase Muconate Lactonizing
KFZ58_07805	COG0179	Fumarylacetoacetate (FAA) hydrolase
KFZ58_07810	COG1301	dicarboxylic acid transport
KFZ58_07840	COG0318	PFAM AMP-dependent synthetase and ligase
KFZ58_07855	COG1252	NADH dehydrogenase
KFZ58_07865	COG2720	vancomycin resistance protein
KFZ58_07870	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
KFZ58_07905	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
KFZ58_07910	COG1966	Carbon starvation protein
KFZ58_07920	COG0003	Pfam Anion-transporting ATPase
KFZ58_07925	COG0604	alcohol dehydrogenase
KFZ58_07930	COG2323	membrane
KFZ58_07965	COG0778	Nitroreductase
KFZ58_07980	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
KFZ58_07985	COG0681	Belongs to the peptidase S26 family
KFZ58_08020	COG1999	signal sequence binding
KFZ58_08025	COG1408	metallophosphoesterase
KFZ58_08035	COG0640	Transcriptional regulator
KFZ58_08040	COG0517	IMP dehydrogenase activity
KFZ58_08050	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KFZ58_08055	COG1132	(ABC) transporter
KFZ58_08060	COG1132	(ABC) transporter
KFZ58_08065	COG0569	domain protein
KFZ58_08070	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
KFZ58_08075	COG5503	Protein of unknown function (DUF1447)
KFZ58_08080	COG0561	phosphatase activity
KFZ58_08085	COG3344	reverse transcriptase
KFZ58_08090	COG0242	peptide deformylase activity
KFZ58_08105	COG0022	dehydrogenase e1 component
KFZ58_08125	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
KFZ58_08145	COG4476	Belongs to the UPF0223 family
KFZ58_08150	COG4493	Belongs to the UPF0637 family
KFZ58_08160	COG0483	inositol monophosphate 1-phosphatase activity
KFZ58_08175	COG4896	Protein conserved in bacteria
KFZ58_08190	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
KFZ58_08195	COG4838	Belongs to the UPF0358 family
KFZ58_08200	COG0772	Belongs to the SEDS family
KFZ58_08205	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
KFZ58_08210	COG1612	heme a metabolic process
KFZ58_08215	COG0109	protoheme IX farnesyltransferase activity
KFZ58_08220	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
KFZ58_08220	COG2010	Cytochrome c
KFZ58_08230	COG1845	cytochrome c oxidase, subunit III
KFZ58_08235	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
KFZ58_08240	COG3336	cytochrome c oxidase
KFZ58_08245	COG2322	membrane
KFZ58_08260	COG2340	Cysteine-rich secretory protein family
KFZ58_08275	COG3679	Belongs to the UPF0342 family
KFZ58_08280	COG4471	UPF0298 protein
KFZ58_08285	COG0742	ribosomal rna small subunit methyltransferase
KFZ58_08290	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
KFZ58_08295	COG3314	Sporulation integral membrane protein YlbJ
KFZ58_08300	COG3480	Lon protease (S16) C-terminal proteolytic domain
KFZ58_08305	COG1323	Belongs to the UPF0348 family
KFZ58_08310	COG1399	metal-binding, possibly nucleic acid-binding protein
KFZ58_08315	COG0333	Belongs to the bacterial ribosomal protein bL32 family
KFZ58_08320	COG1250	3-hydroxyacyl-CoA dehydrogenase
KFZ58_08320	COG1024	Enoyl-CoA hydratase
KFZ58_08330	COG0454	-acetyltransferase
KFZ58_08340	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
KFZ58_08345	COG2001	Belongs to the MraZ family
KFZ58_08350	COG0275	rRNA processing
KFZ58_08355	COG4839	cell division protein FtsL
KFZ58_08360	COG0768	penicillin binding
KFZ58_08365	COG0768	penicillin binding
KFZ58_08370	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
KFZ58_08375	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
KFZ58_08380	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
KFZ58_08385	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
KFZ58_08390	COG0772	Belongs to the SEDS family
KFZ58_08395	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
KFZ58_08400	COG0849	cell division
KFZ58_08405	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
KFZ58_08415	COG1191	sigma factor activity
KFZ58_08420	COG1191	sigma factor activity
KFZ58_08425	COG1873	PFAM PRC-barrel domain
KFZ58_08430	COG1496	oxidoreductase activity
KFZ58_08435	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
KFZ58_08440	COG1799	cell septum assembly
KFZ58_08445	COG0762	integral membrane protein
KFZ58_08450	COG2302	S4 RNA-binding domain
KFZ58_08455	COG3599	regulation of cell shape
KFZ58_08460	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
KFZ58_08465	COG0697	spore germination
KFZ58_08470	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
KFZ58_08475	COG0564	pseudouridine synthase activity
KFZ58_08480	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
KFZ58_08485	COG2233	PERMEase
KFZ58_08490	COG0540	Belongs to the ATCase OTCase family
KFZ58_08495	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
KFZ58_08500	COG0505	Belongs to the CarA family
KFZ58_08515	COG0167	dihydroorotate dehydrogenase activity
KFZ58_08520	COG0284	orotidine-5'-phosphate decarboxylase activity
KFZ58_08525	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
KFZ58_08535	COG2226	methyltransferase
KFZ58_08540	COG0583	DNA-binding transcription factor activity
KFZ58_08545	COG1764	response to oxidative stress
KFZ58_08555	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
KFZ58_08560	COG1561	YicC-like family, N-terminal region
KFZ58_08565	COG2052	Domain of unknown function (DUF370)
KFZ58_08570	COG0194	GDP metabolic process
KFZ58_08575	COG1758	RNA polymerase activity
KFZ58_08580	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
KFZ58_08585	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
KFZ58_08590	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
KFZ58_08595	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
KFZ58_08595	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
KFZ58_08600	COG0631	protein serine/threonine phosphatase activity
KFZ58_08605	COG0515	serine threonine protein kinase
KFZ58_08605	COG2815	serine threonine protein kinase
KFZ58_08610	COG1162	GTPase activity
KFZ58_08615	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
KFZ58_08620	COG1564	THIamine pyrophosphokinase
KFZ58_08630	COG0227	Belongs to the bacterial ribosomal protein bL28 family
KFZ58_08635	COG1302	Protein conserved in bacteria
KFZ58_08640	COG1461	Dihydroxyacetone kinase
KFZ58_08650	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
KFZ58_08655	COG1349	DNA-binding transcription factor activity
KFZ58_08660	COG0416	fatty acid biosynthetic process
KFZ58_08665	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
KFZ58_08670	COG1028	Short-chain dehydrogenase reductase Sdr
KFZ58_08675	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KFZ58_08680	COG0571	ribonuclease III activity
KFZ58_08685	COG4840	Belongs to the UPF0435 family
KFZ58_08690	COG1196	nuclear chromosome segregation
KFZ58_08695	COG0552	protein localization to endoplasmic reticulum
KFZ58_08700	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
KFZ58_08705	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
KFZ58_08710	COG0228	four-way junction DNA binding
KFZ58_08725	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
KFZ58_08730	COG0336	Belongs to the RNA methyltransferase TrmD family
KFZ58_08735	COG0335	large ribosomal subunit rRNA binding
KFZ58_08745	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
KFZ58_08750	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
KFZ58_08760	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
KFZ58_08765	COG0045	succinate-CoA ligase (ADP-forming) activity
KFZ58_08770	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
KFZ58_08775	COG0758	DNA mediated transformation
KFZ58_08780	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
KFZ58_08790	COG4974	Belongs to the 'phage' integrase family
KFZ58_08795	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
KFZ58_08800	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
KFZ58_08805	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
KFZ58_08810	COG1815	bacterial-type flagellum-dependent cell motility
KFZ58_08815	COG1558	bacterial-type flagellum-dependent cell motility
KFZ58_08820	COG1677	Flagellar hook-basal body complex protein FliE
KFZ58_08825	COG1766	The M ring may be actively involved in energy transduction
KFZ58_08830	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
KFZ58_08840	COG1157	protein secretion by the type III secretion system
KFZ58_08860	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
KFZ58_08870	COG4786	Flagellar basal body rod
KFZ58_08875	COG1582	Flagellar protein (FlbD)
KFZ58_08885	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
KFZ58_08890	COG1776	CheC inhibitor of MCP methylation
KFZ58_08890	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
KFZ58_08895	COG2201	protein-glutamate methylesterase activity
KFZ58_08900	COG3190	flagellar
KFZ58_08910	COG1987	bacterial-type flagellum assembly
KFZ58_08915	COG1684	flagellar biosynthetic protein fliR
KFZ58_08920	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
KFZ58_08925	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
KFZ58_08930	COG1419	protein localization to endoplasmic reticulum
KFZ58_08935	COG0455	bacterial-type flagellum organization
KFZ58_08940	COG0835	chemotaxis
KFZ58_08945	COG1191	sigma factor activity
KFZ58_08955	COG0052	Belongs to the universal ribosomal protein uS2 family
KFZ58_08960	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
KFZ58_08965	COG0528	UMP kinase activity
KFZ58_08970	COG0233	cytoplasmic translational termination
KFZ58_08975	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
KFZ58_08980	COG4589	Belongs to the CDS family
KFZ58_08985	COG0750	zinc metalloprotease
KFZ58_08990	COG2176	DNA-directed DNA polymerase activity
KFZ58_08995	COG0779	Required for maturation of 30S ribosomal subunits
KFZ58_09000	COG0195	Participates in both transcription termination and antitermination
KFZ58_09005	COG2740	Nucleic-acid-binding protein implicated in transcription termination
KFZ58_09015	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
KFZ58_09020	COG1550	Protein conserved in bacteria
KFZ58_09025	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
KFZ58_09030	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
KFZ58_09040	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
KFZ58_09045	COG1185	polyribonucleotide nucleotidyltransferase activity
KFZ58_09050	COG0726	polysaccharide deacetylase
KFZ58_09055	COG0612	Peptidase, M16
KFZ58_09060	COG1873	PFAM PRC-barrel domain
KFZ58_09065	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
KFZ58_09070	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
KFZ58_09075	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
KFZ58_09080	COG0527	aspartate kinase activity
KFZ58_09090	COG0740	serine-type endopeptidase activity
KFZ58_09100	COG1674	ftsk spoiiie
KFZ58_09105	COG1744	ABC transporter substrate-binding protein PnrA-like
KFZ58_09110	COG3845	ABC transporter
KFZ58_09115	COG4603	Belongs to the binding-protein-dependent transport system permease family
KFZ58_09120	COG1079	Belongs to the binding-protein-dependent transport system permease family
KFZ58_09125	COG0612	Peptidase, M16
KFZ58_09130	COG0612	Peptidase, M16
KFZ58_09135	COG0300	oxidoreductase activity
KFZ58_09150	COG1426	Protein conserved in bacteria
KFZ58_09155	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
KFZ58_09160	COG1058	Belongs to the CinA family
KFZ58_09160	COG1546	Belongs to the CinA family
KFZ58_09165	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
KFZ58_09170	COG1418	mRNA catabolic process
KFZ58_09175	COG1692	metallophosphoesterase
KFZ58_09180	COG2359	stage V sporulation protein S
KFZ58_09185	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
KFZ58_09190	COG4550	Control of competence regulator ComK, YlbF/YmcA
KFZ58_09200	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
KFZ58_09205	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
KFZ58_09210	COG0783	Belongs to the Dps family
KFZ58_09215	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
KFZ58_09220	COG1923	regulation of RNA biosynthetic process
KFZ58_09225	COG0464	growth
KFZ58_09230	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
KFZ58_09235	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
KFZ58_09240	COG0789	Transcriptional regulator
KFZ58_09245	COG0174	glutamine synthetase
KFZ58_09250	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
KFZ58_09255	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
KFZ58_09260	COG4224	UPF0291 protein
KFZ58_09275	COG3763	UPF0154 protein
KFZ58_09280	COG0785	Cytochrome C biogenesis protein
KFZ58_09285	COG4846	Membrane protein involved in cytochrome C biogenesis
KFZ58_09295	COG4191	Histidine kinase
KFZ58_09300	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
KFZ58_09305	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KFZ58_09320	COG0824	Thioesterase
KFZ58_09335	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
KFZ58_09340	COG1469	GTP cyclohydrolase I activity
KFZ58_09345	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
KFZ58_09355	COG1174	glycine betaine transport
KFZ58_09360	COG1832	CoA-binding protein
KFZ58_09365	COG0187	DNA topoisomerase II activity
KFZ58_09370	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
KFZ58_09375	COG1960	acyl-CoA dehydrogenase activity
KFZ58_09380	COG0439	Biotin carboxylase
KFZ58_09385	COG0511	ligase activity, forming carbon-carbon bonds
KFZ58_09390	COG1024	Enoyl-CoA hydratase
KFZ58_09395	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
KFZ58_09400	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
KFZ58_09405	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KFZ58_09410	COG0723	plastoquinol--plastocyanin reductase activity
KFZ58_09410	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KFZ58_09425	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
KFZ58_09430	COG1254	Belongs to the acylphosphatase family
KFZ58_09450	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KFZ58_09450	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KFZ58_09460	COG4479	Belongs to the UPF0346 family
KFZ58_09465	COG0805	protein transport
KFZ58_09470	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
KFZ58_09475	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
KFZ58_09480	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
KFZ58_09485	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
KFZ58_09490	COG1418	mRNA catabolic process
KFZ58_09505	COG1755	Isoprenylcysteine carboxyl methyltransferase
KFZ58_09510	COG3424	synthase
KFZ58_09515	COG0116	Belongs to the methyltransferase superfamily
KFZ58_09525	COG3599	regulation of cell shape
KFZ58_09530	COG0295	cytidine deaminase activity
KFZ58_09560	COG3331	DNA recombination
KFZ58_09565	COG4499	WXG100 protein secretion system (Wss), protein YukC
KFZ58_09565	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KFZ58_09570	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
KFZ58_09575	COG3935	DnaD domain protein
KFZ58_09580	COG0017	Asparaginyl-tRNA synthetase
KFZ58_09585	COG0436	Aminotransferase
KFZ58_09595	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
KFZ58_09595	COG1199	ATP-dependent helicase activity
KFZ58_09605	COG0617	tRNA 3'-terminal CCA addition
KFZ58_09610	COG0438	transferase activity, transferring glycosyl groups
KFZ58_09615	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
KFZ58_09620	COG1694	Mazg nucleotide pyrophosphohydrolase
KFZ58_09625	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KFZ58_09630	COG2738	Putative neutral zinc metallopeptidase
KFZ58_09640	COG4347	Protein of unknown function (DUF1405)
KFZ58_09650	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
KFZ58_09655	COG0723	plastoquinol--plastocyanin reductase activity
KFZ58_09665	COG5582	Belongs to the UPF0302 family
KFZ58_09670	COG0457	Tetratricopeptide repeat
KFZ58_09675	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
KFZ58_09680	COG0287	Prephenate dehydrogenase
KFZ58_09685	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
KFZ58_09690	COG4401	Chorismate mutase type I
KFZ58_09695	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
KFZ58_09700	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
KFZ58_09705	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
KFZ58_09710	COG0105	UTP biosynthetic process
KFZ58_09720	COG2226	methyltransferase
KFZ58_09725	COG0142	geranyltranstransferase activity
KFZ58_09730	COG0776	regulation of translation
KFZ58_09735	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
KFZ58_09755	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
KFZ58_09760	COG1160	GTP binding
KFZ58_09770	COG0539	negative regulation of cytoplasmic translation
KFZ58_09780	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
KFZ58_09785	COG2959	enzyme of heme biosynthesis
KFZ58_09790	COG3409	Peptidoglycan-binding domain 1 protein
KFZ58_09790	COG3773	Cell wall hydrolase
KFZ58_09800	COG0492	ferredoxin-NADP+ reductase activity
KFZ58_09805	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
KFZ58_09810	COG4862	establishment of competence for transformation
KFZ58_09825	COG0514	ATP-dependent DNA helicase (RecQ)
KFZ58_09835	COG5002	protein histidine kinase activity
KFZ58_09840	COG0745	RESPONSE REGULATOR receiver
KFZ58_09845	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
KFZ58_09850	COG1333	cytochrome c biogenesis protein
KFZ58_09855	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KFZ58_09860	COG1187	pseudouridine synthase activity
KFZ58_09865	COG0700	Nucleoside recognition
KFZ58_09870	COG2715	membrane protein required for spore maturation
KFZ58_09875	COG1686	Belongs to the peptidase S11 family
KFZ58_09880	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
KFZ58_09885	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
KFZ58_09890	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
KFZ58_09910	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
KFZ58_09920	COG0697	spore germination
KFZ58_09935	COG1191	sigma factor activity
KFZ58_09940	COG2172	sigma factor antagonist activity
KFZ58_09950	COG1686	Belongs to the peptidase S11 family
KFZ58_09965	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
KFZ58_09970	COG4974	Belongs to the 'phage' integrase family
KFZ58_09980	COG0735	belongs to the Fur family
KFZ58_09985	COG1300	Membrane
KFZ58_09990	COG1379	DNA repair
KFZ58_09995	COG3583	domain protein
KFZ58_09995	COG3584	3D domain protein
KFZ58_10005	COG0667	Aldo Keto reductase
KFZ58_10010	COG0300	oxidoreductase activity
KFZ58_10015	COG4187	Peptidase family M20/M25/M40
KFZ58_10020	COG0584	glycerophosphoryl diester phosphodiesterase
KFZ58_10030	COG1012	belongs to the aldehyde dehydrogenase family
KFZ58_10035	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
KFZ58_10040	COG2195	Cleaves the N-terminal amino acid of tripeptides
KFZ58_10045	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
KFZ58_10050	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
KFZ58_10050	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
KFZ58_10055	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
KFZ58_10055	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
KFZ58_10065	COG4129	membrane
KFZ58_10075	COG0508	dehydrogenase complex catalyzes the overall conversion of
KFZ58_10080	COG0022	dehydrogenase e1 component
KFZ58_10085	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
KFZ58_10090	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KFZ58_10095	COG3426	butyrate kinase activity
KFZ58_10105	COG0280	phosphate acetyltransferase
KFZ58_10110	COG3290	protein histidine kinase activity
KFZ58_10110	COG3829	transcription factor binding
KFZ58_10120	COG0527	aspartate kinase activity
KFZ58_10130	COG0750	zinc metalloprotease
KFZ58_10135	COG0497	DNA recombination
KFZ58_10140	COG1438	arginine binding
KFZ58_10145	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
KFZ58_10155	COG0142	geranyltranstransferase activity
KFZ58_10160	COG1722	exodeoxyribonuclease VII activity
KFZ58_10165	COG1570	exodeoxyribonuclease VII activity
KFZ58_10170	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
KFZ58_10175	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
KFZ58_10180	COG1302	Protein conserved in bacteria
KFZ58_10185	COG0439	Biotin carboxylase
KFZ58_10190	COG0511	ligase activity, forming carbon-carbon bonds
KFZ58_10230	COG3854	ATPases associated with a variety of cellular activities
KFZ58_10235	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
KFZ58_10240	COG0006	proline dipeptidase activity
KFZ58_10255	COG1752	Esterase of the alpha-beta hydrolase superfamily
KFZ58_10260	COG1321	iron dependent repressor
KFZ58_10295	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
KFZ58_10300	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
KFZ58_10305	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
KFZ58_10315	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
KFZ58_10330	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
KFZ58_10335	COG1459	type II secretion system
KFZ58_10340	COG4537	Required for transformation and DNA binding
KFZ58_10345	COG2165	general secretion pathway protein
KFZ58_10375	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KFZ58_10385	COG1368	sulfuric ester hydrolase activity
KFZ58_10390	COG1940	carbohydrate kinase activity
KFZ58_10400	COG0705	Rhomboid family
KFZ58_10400	COG0457	Tetratricopeptide repeat
KFZ58_10410	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
KFZ58_10415	COG0267	Belongs to the bacterial ribosomal protein bL33 family
KFZ58_10430	COG0768	penicillin binding
KFZ58_10435	COG0477	Major facilitator Superfamily
KFZ58_10440	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
KFZ58_10475	COG0704	Plays a role in the regulation of phosphate uptake
KFZ58_10480	COG1030	water channel activity
KFZ58_10490	COG4709	membrane
KFZ58_10500	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
KFZ58_10505	COG0513	Belongs to the DEAD box helicase family
KFZ58_10510	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
KFZ58_10515	COG2384	SAM-dependent methyltransferase
KFZ58_10525	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
KFZ58_10530	COG0358	DNA primase activity
KFZ58_10535	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
KFZ58_10540	COG0517	IMP dehydrogenase activity
KFZ58_10545	COG0751	glycine-tRNA ligase activity
KFZ58_10550	COG0752	glycyl-tRNA synthetase alpha subunit
KFZ58_10555	COG1381	Involved in DNA repair and RecF pathway recombination
KFZ58_10565	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
KFZ58_10575	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
KFZ58_10585	COG1702	phosphate starvation-inducible protein PhoH
KFZ58_10605	COG4864	UPF0365 protein
KFZ58_10610	COG1030	water channel activity
KFZ58_10615	COG1610	YqeY-like protein
KFZ58_10620	COG0828	Belongs to the bacterial ribosomal protein bS21 family
KFZ58_10625	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
KFZ58_10630	COG1385	rRNA (uridine-N3-)-methyltransferase activity
KFZ58_10635	COG2264	protein methyltransferase activity
KFZ58_10640	COG0484	heat shock protein binding
KFZ58_10645	COG0443	Heat shock 70 kDa protein
KFZ58_10650	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
KFZ58_10655	COG1420	regulation of RNA biosynthetic process
KFZ58_10660	COG0481	GTPase activity
KFZ58_10670	COG0860	N-Acetylmuramoyl-L-alanine amidase
KFZ58_10675	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
KFZ58_10680	COG0268	Binds directly to 16S ribosomal RNA
KFZ58_10690	COG1466	dna polymerase III delta subunit
KFZ58_10700	COG2333	competence protein COMEC
KFZ58_10700	COG0658	competence protein
KFZ58_10705	COG2131	deaminase
KFZ58_10710	COG1596	polysaccharide export
KFZ58_10710	COG1555	photosystem II stabilization
KFZ58_10715	COG2226	methyltransferase
KFZ58_10720	COG0799	negative regulation of ribosome biogenesis
KFZ58_10725	COG1713	HD superfamily hydrolase involved in NAD metabolism
KFZ58_10730	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
KFZ58_10735	COG1534	Rna-binding protein
KFZ58_10740	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
KFZ58_10745	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
KFZ58_10750	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
KFZ58_10760	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
KFZ58_10760	COG2111	Na H antiporter
KFZ58_10765	COG2111	Na H antiporter
KFZ58_10770	COG1006	Multisubunit Na H antiporter MnhC subunit
KFZ58_10775	COG0651	ATP synthesis coupled electron transport
KFZ58_10780	COG1863	multisubunit Na H antiporter MnhE subunit
KFZ58_10785	COG2212	antiporter activity
KFZ58_10790	COG1320	monovalent cation:proton antiporter activity
KFZ58_10795	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
KFZ58_10805	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
KFZ58_10815	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
KFZ58_10820	COG0572	uridine kinase
KFZ58_10825	COG4122	O-methyltransferase activity
KFZ58_10830	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
KFZ58_10835	COG3906	Belongs to the UPF0473 family
KFZ58_10840	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
KFZ58_10845	COG4472	Bacterial protein of unknown function (DUF965)
KFZ58_10850	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
KFZ58_10855	COG0628	permease
KFZ58_10865	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
KFZ58_10875	COG0482	sulfurtransferase activity
KFZ58_10880	COG1104	cysteine desulfurase activity
KFZ58_10885	COG1959	2 iron, 2 sulfur cluster binding
KFZ58_10890	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
KFZ58_10905	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
KFZ58_10910	COG0124	histidyl-tRNA synthetase
KFZ58_10920	COG0860	N-Acetylmuramoyl-L-alanine amidase
KFZ58_10920	COG3103	Sh3 type 3 domain protein
KFZ58_10920	COG4991	sh3 domain protein
KFZ58_10925	COG1490	D-aminoacyl-tRNA deacylase activity
KFZ58_10930	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
KFZ58_10935	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
KFZ58_10940	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
KFZ58_10940	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
KFZ58_10945	COG5416	Lipopolysaccharide assembly protein A domain
KFZ58_10950	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
KFZ58_10950	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
KFZ58_10960	COG2244	polysaccharide biosynthetic process
KFZ58_10980	COG1862	Preprotein translocase
KFZ58_10985	COG0343	queuine tRNA-ribosyltransferase activity
KFZ58_10990	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
KFZ58_11000	COG2255	four-way junction helicase activity
KFZ58_11005	COG0632	four-way junction helicase activity
KFZ58_11010	COG0217	transcriptional regulatory protein
KFZ58_11020	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
KFZ58_11035	COG0077	Prephenate dehydratase
KFZ58_11040	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
KFZ58_11050	COG0211	Belongs to the bacterial ribosomal protein bL27 family
KFZ58_11055	COG2868	ribosomal protein
KFZ58_11060	COG0261	This protein binds to 23S rRNA in the presence of protein L20
KFZ58_11065	COG1994	Peptidase M50
KFZ58_11075	COG2894	cell division
KFZ58_11080	COG0850	regulation of cytokinetic process
KFZ58_11095	COG1077	Cell shape determining protein MreB Mrl
KFZ58_11100	COG2003	Belongs to the UPF0758 family
KFZ58_11110	COG0285	dihydrofolate synthase activity
KFZ58_11125	COG0525	valine-tRNA ligase activity
KFZ58_11140	COG1388	LysM domain
KFZ58_11140	COG1388	LysM domain
KFZ58_11145	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
KFZ58_11150	COG0113	porphobilinogen synthase activity
KFZ58_11160	COG0181	hydroxymethylbilane synthase activity
KFZ58_11165	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
KFZ58_11175	COG0218	Necessary for normal cell division and for the maintenance of normal septation
KFZ58_11185	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
KFZ58_11190	COG0544	peptidyl-prolyl cis-trans isomerase activity
KFZ58_11210	COG0622	Phosphoesterase
KFZ58_11215	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
KFZ58_11220	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
KFZ58_11225	COG5401	PFAM Sporulation and spore germination
KFZ58_11230	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
KFZ58_11235	COG1846	Transcriptional regulator
KFZ58_11240	COG2197	response regulator
KFZ58_11245	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
KFZ58_11250	COG1053	succinate dehydrogenase
KFZ58_11255	COG2009	succinate dehydrogenase
KFZ58_11260	COG1719	4-vinyl reductase, 4VR
KFZ58_11265	COG0322	excinuclease ABC activity
KFZ58_11270	COG3118	belongs to the thioredoxin family
KFZ58_11275	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
KFZ58_11280	COG2086	electron transfer activity
KFZ58_11285	COG1024	Enoyl-CoA hydratase
KFZ58_11290	COG1309	transcriptional regulator
KFZ58_11295	COG0318	PFAM AMP-dependent synthetase and ligase
KFZ58_11300	COG1193	negative regulation of DNA recombination
KFZ58_11305	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
KFZ58_11305	COG1796	DNA polymerase
KFZ58_11310	COG1286	toxin biosynthetic process
KFZ58_11315	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
KFZ58_11320	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
KFZ58_11325	COG0072	phenylalanine-tRNA ligase activity
KFZ58_11325	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KFZ58_11330	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
KFZ58_11335	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KFZ58_11360	COG1131	(ABC) transporter
KFZ58_11365	COG0741	lytic transglycosylase activity
KFZ58_11370	COG1363	Peptidase, m42
KFZ58_11390	COG0398	Pfam SNARE associated Golgi protein
KFZ58_11400	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
KFZ58_11405	COG0291	Belongs to the bacterial ribosomal protein bL35 family
KFZ58_11410	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
KFZ58_11415	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
KFZ58_11425	COG1484	DNA-dependent DNA replication
KFZ58_11430	COG3611	Membrane attachment protein
KFZ58_11435	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
KFZ58_11445	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
KFZ58_11450	COG0237	dephospho-CoA kinase activity
KFZ58_11455	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
KFZ58_11460	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KFZ58_11460	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KFZ58_11465	COG5002	protein histidine kinase activity
KFZ58_11470	COG0745	RESPONSE REGULATOR receiver
KFZ58_11480	COG0039	L-malate dehydrogenase activity
KFZ58_11485	COG0538	isocitrate dehydrogenase activity
KFZ58_11490	COG0372	Belongs to the citrate synthase family
KFZ58_11495	COG0628	permease
KFZ58_11500	COG3030	protein affecting phage T7 exclusion by the F plasmid
KFZ58_11510	COG0205	6-phosphofructokinase activity
KFZ58_11515	COG0825	malonyl-CoA metabolic process
KFZ58_11520	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
KFZ58_11525	COG1725	Transcriptional regulator
KFZ58_11530	COG0281	malic enzyme
KFZ58_11535	COG0587	DNA-directed DNA polymerase activity
KFZ58_11550	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
KFZ58_11560	COG4109	DRTGG domain
KFZ58_11570	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
KFZ58_11580	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
KFZ58_11585	COG2814	Major facilitator Superfamily
KFZ58_11595	COG2233	PERMEase
KFZ58_11600	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
KFZ58_11610	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
KFZ58_11615	COG1842	Phage shock protein A
KFZ58_11620	COG0006	proline dipeptidase activity
KFZ58_11635	COG0589	response to stress
KFZ58_11640	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
KFZ58_11645	COG0827	DNA restriction-modification system
KFZ58_11650	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
KFZ58_11655	COG3874	Sporulation protein YtfJ
KFZ58_11665	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
KFZ58_11675	COG0301	tRNA thio-modification
KFZ58_11680	COG1104	cysteine desulfurase activity
KFZ58_11685	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
KFZ58_11690	COG1309	transcriptional regulator
KFZ58_11695	COG1956	GAF domain-containing protein
KFZ58_11700	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
KFZ58_11710	COG1263	PTS System
KFZ58_11710	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KFZ58_11715	COG2190	(PTS) system
KFZ58_11720	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
KFZ58_11730	COG0454	-acetyltransferase
KFZ58_11735	COG0517	IMP dehydrogenase activity
KFZ58_11740	COG0123	including yeast histone deacetylase and acetoin utilization protein
KFZ58_11760	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
KFZ58_11760	COG1605	Chorismate mutase
KFZ58_11775	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
KFZ58_11785	COG1674	ftsk spoiiie
KFZ58_11790	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KFZ58_11795	COG4848	Belongs to the UPF0354 family
KFZ58_11800	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KFZ58_11810	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
KFZ58_11825	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KFZ58_11830	COG0220	tRNA (guanine-N7-)-methyltransferase activity
KFZ58_11840	COG0510	thiamine kinase activity
KFZ58_11850	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
KFZ58_11855	COG1187	pseudouridine synthase activity
KFZ58_11860	COG2244	polysaccharide biosynthetic process
KFZ58_11865	COG2081	HI0933 family
KFZ58_11890	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
KFZ58_11900	COG0495	leucyl-tRNA aminoacylation
KFZ58_11905	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
KFZ58_11915	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
KFZ58_11920	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
KFZ58_11925	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
KFZ58_11930	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
KFZ58_11935	COG1116	anion transmembrane transporter activity
KFZ58_11940	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
KFZ58_11945	COG0494	nUDIX hydrolase
KFZ58_11960	COG1120	ATPase activity
KFZ58_11965	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
KFZ58_11970	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KFZ58_11975	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KFZ58_11980	COG0492	ferredoxin-NADP+ reductase activity
KFZ58_11985	COG0626	cystathionine gamma-synthase activity
KFZ58_11995	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
KFZ58_12000	COG0596	Alpha beta hydrolase
KFZ58_12010	COG1169	isochorismate synthase
KFZ58_12015	COG1575	Belongs to the MenA family. Type 1 subfamily
KFZ58_12020	COG2050	protein possibly involved in aromatic compounds catabolism
KFZ58_12025	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
KFZ58_12030	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
KFZ58_12035	COG1404	Belongs to the peptidase S8 family
KFZ58_12035	COG4412	M6 family metalloprotease domain protein
KFZ58_12050	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
KFZ58_12055	COG1098	S1 RNA binding domain
KFZ58_12060	COG0166	Belongs to the GPI family
KFZ58_12065	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
KFZ58_12090	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
KFZ58_12110	COG1131	(ABC) transporter
KFZ58_12115	COG2197	response regulator
KFZ58_12120	COG4585	Histidine kinase
KFZ58_12125	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KFZ58_12125	COG0723	plastoquinol--plastocyanin reductase activity
KFZ58_12130	COG0813	purine-nucleoside phosphorylase activity
KFZ58_12135	COG1268	BioY protein
KFZ58_12140	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
KFZ58_12145	COG3584	3D domain protein
KFZ58_12155	COG1252	NADH dehydrogenase
KFZ58_12160	COG0492	ferredoxin-NADP+ reductase activity
KFZ58_12175	COG0316	Belongs to the HesB IscA family
KFZ58_12185	COG1028	Short-chain dehydrogenase reductase Sdr
KFZ58_12195	COG0739	heme binding
KFZ58_12200	COG0789	Transcriptional regulator
KFZ58_12205	COG1131	(ABC) transporter
KFZ58_12240	COG1288	antiporter activity
KFZ58_12260	COG4837	Protein of unknown function (DUF1462)
KFZ58_12265	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
KFZ58_12270	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
KFZ58_12275	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
KFZ58_12280	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
KFZ58_12285	COG0647	UMP catabolic process
KFZ58_12290	COG2445	Protein of unknown function DUF86
KFZ58_12300	COG4470	Protein conserved in bacteria
KFZ58_12310	COG0739	heme binding
KFZ58_12320	COG0733	neurotransmitter:sodium symporter activity
KFZ58_12325	COG1757	Na H antiporter
KFZ58_12335	COG3377	Domain of unknown function (DUF1805)
KFZ58_12340	COG0737	Belongs to the 5'-nucleotidase family
KFZ58_12345	COG0730	response to heat
KFZ58_12350	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
KFZ58_12355	COG0436	Aminotransferase
KFZ58_12365	COG0719	Fe-S assembly protein
KFZ58_12370	COG0822	iron-sulfur transferase activity
KFZ58_12375	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
KFZ58_12380	COG0719	Fe-S assembly protein
KFZ58_12385	COG0396	ATPase activity
KFZ58_12395	COG1464	Belongs to the NlpA lipoprotein family
KFZ58_12400	COG2011	ABC-type metal ion transport system permease component
KFZ58_12405	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
KFZ58_12410	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KFZ58_12415	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
KFZ58_12420	COG0509	glycine decarboxylation via glycine cleavage system
KFZ58_12425	COG1393	Belongs to the ArsC family
KFZ58_12430	COG1960	acyl-CoA dehydrogenase activity
KFZ58_12435	COG0183	Belongs to the thiolase family
KFZ58_12440	COG1024	Enoyl-CoA hydratase
KFZ58_12440	COG1250	3-hydroxyacyl-CoA dehydrogenase
KFZ58_12450	COG0803	Belongs to the bacterial solute-binding protein 9 family
KFZ58_12455	COG1121	(ABC) transporter
KFZ58_12460	COG1108	ABC-type Mn2 Zn2 transport systems permease components
KFZ58_12465	COG0735	belongs to the Fur family
KFZ58_12475	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KFZ58_12485	COG2224	Isocitrate lyase
KFZ58_12495	COG4129	membrane
KFZ58_12500	COG2197	response regulator
KFZ58_12505	COG4585	Histidine kinase
KFZ58_12525	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KFZ58_12555	COG4473	ABC transporter
KFZ58_12560	COG1131	(ABC) transporter
KFZ58_12570	COG2843	Capsule synthesis protein
KFZ58_12580	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
KFZ58_12595	COG0010	Belongs to the arginase family
KFZ58_12600	COG1122	ATPase activity
KFZ58_12640	COG3639	organic phosphonate transmembrane transporter activity
KFZ58_12645	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
KFZ58_12665	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
KFZ58_12670	COG0428	transporter
KFZ58_12675	COG0557	exoribonuclease II activity
KFZ58_12680	COG1647	Serine aminopeptidase, S33
KFZ58_12685	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
KFZ58_12695	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
KFZ58_12705	COG1131	(ABC) transporter
KFZ58_12710	COG1725	Transcriptional regulator
KFZ58_12760	COG0148	phosphopyruvate hydratase activity
KFZ58_12765	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
KFZ58_12770	COG0149	triose-phosphate isomerase activity
KFZ58_12775	COG0126	phosphoglycerate kinase activity
KFZ58_12815	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
KFZ58_12825	COG0328	RNA-DNA hybrid ribonuclease activity
KFZ58_12830	COG2267	carboxylic ester hydrolase activity
KFZ58_12835	COG0179	Fumarylacetoacetate (FAA) hydrolase
KFZ58_12850	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KFZ58_12855	COG0601	transmembrane transport
KFZ58_12860	COG0747	negative chemotaxis
KFZ58_12865	COG4608	Belongs to the ABC transporter superfamily
KFZ58_12870	COG0444	Belongs to the ABC transporter superfamily
KFZ58_12875	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
KFZ58_12885	COG1119	ATPase activity
KFZ58_12895	COG0740	serine-type endopeptidase activity
KFZ58_12900	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
KFZ58_12905	COG1481	regulation of sporulation
KFZ58_12910	COG0391	Required for morphogenesis under gluconeogenic growth conditions
KFZ58_12915	COG1660	Displays ATPase and GTPase activities
KFZ58_12920	COG0492	ferredoxin-NADP+ reductase activity
KFZ58_12925	COG0457	Tetratricopeptide repeat
KFZ58_12930	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
KFZ58_12935	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
KFZ58_12940	COG0110	maltose O-acetyltransferase activity
KFZ58_12945	COG0546	phosphoglycolate phosphatase activity
KFZ58_12950	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
KFZ58_12955	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
KFZ58_12960	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
KFZ58_12965	COG1950	PFAM Membrane protein of
KFZ58_12970	COG1983	PspC domain protein
KFZ58_12980	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
KFZ58_12985	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
KFZ58_12990	COG0556	nucleotide-excision repair
KFZ58_12995	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
KFZ58_13000	COG1408	metallophosphoesterase
KFZ58_13005	COG0726	polysaccharide deacetylase
KFZ58_13015	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KFZ58_13020	COG0793	Belongs to the peptidase S41A family
KFZ58_13020	COG3409	Peptidoglycan-binding domain 1 protein
KFZ58_13025	COG0791	NLP P60 protein
KFZ58_13025	COG3883	PFAM NLP P60 protein
KFZ58_13030	COG2177	Part of the ABC transporter FtsEX involved in
KFZ58_13035	COG2884	Cell division ATP-binding protein ftsE
KFZ58_13050	COG0653	protein targeting
KFZ58_13060	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
KFZ58_13080	COG1012	belongs to the aldehyde dehydrogenase family
KFZ58_13090	COG1516	flagellar protein fliS
KFZ58_13095	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
KFZ58_13100	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
KFZ58_13105	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
KFZ58_13110	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
KFZ58_13115	COG4786	Flagellar basal body rod
KFZ58_13115	COG1256	bacterial-type flagellum assembly
KFZ58_13140	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
KFZ58_13145	COG1307	EDD domain protein, DegV family
KFZ58_13150	COG2197	response regulator
KFZ58_13160	COG1739	Uncharacterized protein family UPF0029
KFZ58_13165	COG0363	glucosamine-6-phosphate deaminase activity
KFZ58_13170	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
KFZ58_13195	COG0681	Belongs to the peptidase S26 family
KFZ58_13215	COG3764	Sortase (surface protein transpeptidase)
KFZ58_13220	COG1316	TRANSCRIPTIONal
KFZ58_13225	COG0768	penicillin binding
KFZ58_13230	COG1012	belongs to the aldehyde dehydrogenase family
KFZ58_13265	COG0583	DNA-binding transcription factor activity
KFZ58_13275	COG0561	phosphatase activity
KFZ58_13285	COG1984	allophanate hydrolase subunit 2
KFZ58_13290	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
KFZ58_13295	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
KFZ58_13300	COG0471	metal ion transport
KFZ58_13305	COG2814	Major facilitator Superfamily
KFZ58_13310	COG2807	transmembrane transport
KFZ58_13320	COG1012	belongs to the aldehyde dehydrogenase family
KFZ58_13325	COG0697	spore germination
KFZ58_13345	COG0010	Belongs to the arginase family
KFZ58_13350	COG0395	ABC-type sugar transport system, permease component
KFZ58_13355	COG1175	transmembrane transport
KFZ58_13365	COG3876	Protein conserved in bacteria
KFZ58_13370	COG1472	Belongs to the glycosyl hydrolase 3 family
KFZ58_13375	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
KFZ58_13380	COG3876	Protein conserved in bacteria
KFZ58_13385	COG1486	melibiose metabolic process
KFZ58_13400	COG0395	ABC-type sugar transport system, permease component
KFZ58_13405	COG1175	transmembrane transport
KFZ58_13410	COG1653	transport
KFZ58_13415	COG3876	Protein conserved in bacteria
KFZ58_13425	COG1737	Transcriptional regulator
KFZ58_13430	COG2971	BadF BadG BcrA BcrD
KFZ58_13435	COG0716	FMN binding
KFZ58_13440	COG1331	Highly conserved protein containing a thioredoxin domain
KFZ58_13465	COG1971	Probably functions as a manganese efflux pump
KFZ58_13470	COG1028	Short-chain dehydrogenase reductase Sdr
KFZ58_13480	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KFZ58_13485	COG2996	Protein conserved in bacteria
KFZ58_13500	COG4895	conserved protein (DUF2196)
KFZ58_13530	COG1129	ABC transporter
KFZ58_13535	COG0745	RESPONSE REGULATOR receiver
KFZ58_13545	COG1757	Na H antiporter
KFZ58_13550	COG0561	phosphatase activity
KFZ58_13555	COG2059	Chromate
KFZ58_13560	COG2059	Chromate
KFZ58_13565	COG0405	Gamma-glutamyltransferase
KFZ58_13570	COG1522	sequence-specific DNA binding
KFZ58_13575	COG1115	amino acid carrier protein
KFZ58_13580	COG1116	anion transmembrane transporter activity
KFZ58_13585	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KFZ58_13590	COG1024	Enoyl-CoA hydratase
KFZ58_13595	COG1804	L-carnitine dehydratase bile acid-inducible protein F
KFZ58_13600	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
KFZ58_13605	COG0066	3-isopropylmalate dehydratase activity
KFZ58_13610	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
KFZ58_13615	COG0473	3-isopropylmalate dehydrogenase activity
KFZ58_13620	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
KFZ58_13625	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
KFZ58_13630	COG0440	acetolactate synthase activity
KFZ58_13640	COG0129	dihydroxy-acid dehydratase activity
KFZ58_13645	COG0385	Bile acid
KFZ58_13655	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
KFZ58_13660	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
KFZ58_13665	COG1461	Dihydroxyacetone kinase
KFZ58_13670	COG2376	Dihydroxyacetone kinase
KFZ58_13675	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
KFZ58_13680	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
KFZ58_13685	COG1063	alcohol dehydrogenase
KFZ58_13695	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
KFZ58_13700	COG0530	calcium, potassium:sodium antiporter activity
KFZ58_13705	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
KFZ58_13715	COG4166	transmembrane transport
KFZ58_13725	COG0601	transmembrane transport
KFZ58_13730	COG4608	Belongs to the ABC transporter superfamily
KFZ58_13740	COG1960	acyl-CoA dehydrogenase activity
KFZ58_13755	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
KFZ58_13760	COG1088	dTDP-glucose 4,6-dehydratase activity
KFZ58_13765	COG0463	Glycosyl transferase, family 2
KFZ58_13775	COG2076	Multidrug Resistance protein
KFZ58_13780	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
KFZ58_13805	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KFZ58_13810	COG0656	L-ascorbic acid biosynthetic process
KFZ58_13815	COG1116	anion transmembrane transporter activity
KFZ58_13820	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
KFZ58_13875	COG1028	Short-chain dehydrogenase reductase Sdr
KFZ58_13880	COG1024	Enoyl-CoA hydratase
KFZ58_13885	COG1960	acyl-CoA dehydrogenase activity
KFZ58_13890	COG1250	3-hydroxyacyl-CoA dehydrogenase
KFZ58_13895	COG0183	Belongs to the thiolase family
KFZ58_13900	COG1028	Short-chain dehydrogenase reductase Sdr
KFZ58_13905	COG0318	PFAM AMP-dependent synthetase and ligase
KFZ58_13910	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
KFZ58_13915	COG1960	acyl-CoA dehydrogenase activity
KFZ58_13925	COG2610	gluconate transmembrane transporter activity
KFZ58_13940	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KFZ58_13945	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KFZ58_13950	COG2070	2-Nitropropane dioxygenase
KFZ58_13955	COG0604	alcohol dehydrogenase
KFZ58_13955	COG1028	Short-chain dehydrogenase reductase Sdr
KFZ58_13955	COG3321	synthase
KFZ58_13985	COG1804	L-carnitine dehydratase bile acid-inducible protein F
KFZ58_13990	COG0183	Belongs to the thiolase family
KFZ58_14020	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
KFZ58_14025	COG2079	MmgE PrpD family protein
KFZ58_14045	COG0318	PFAM AMP-dependent synthetase and ligase
KFZ58_14050	COG1024	Enoyl-CoA hydratase
KFZ58_14060	COG0183	Belongs to the thiolase family
KFZ58_14080	COG1960	acyl-CoA dehydrogenase activity
KFZ58_14090	COG4145	pantothenate transmembrane transporter activity
KFZ58_14105	COG1028	Short-chain dehydrogenase reductase Sdr
KFZ58_14110	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
KFZ58_14115	COG2610	gluconate transmembrane transporter activity
KFZ58_14130	COG0318	PFAM AMP-dependent synthetase and ligase
KFZ58_14135	COG0511	ligase activity, forming carbon-carbon bonds
KFZ58_14145	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
KFZ58_14150	COG1024	Enoyl-CoA hydratase
KFZ58_14155	COG0508	dehydrogenase complex catalyzes the overall conversion of
KFZ58_14160	COG0022	dehydrogenase e1 component
KFZ58_14170	COG0659	secondary active sulfate transmembrane transporter activity
KFZ58_14175	COG1250	3-hydroxyacyl-CoA dehydrogenase
KFZ58_14180	COG0318	PFAM AMP-dependent synthetase and ligase
KFZ58_14190	COG0318	PFAM AMP-dependent synthetase and ligase
KFZ58_14200	COG2045	Belongs to the ComB family
KFZ58_14215	COG1028	Short-chain dehydrogenase reductase Sdr
KFZ58_14225	COG1028	Short-chain dehydrogenase reductase Sdr
KFZ58_14230	COG1012	belongs to the aldehyde dehydrogenase family
KFZ58_14235	COG2610	gluconate transmembrane transporter activity
KFZ58_14265	COG2358	TRAP transporter, solute receptor (TAXI family
KFZ58_14270	COG0579	oxidoreductase
KFZ58_14275	COG1028	Short-chain dehydrogenase reductase Sdr
KFZ58_14290	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
KFZ58_14310	COG1802	Transcriptional regulator
KFZ58_14335	COG1024	Enoyl-CoA hydratase
KFZ58_14350	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
KFZ58_14360	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
KFZ58_14375	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
KFZ58_14385	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
KFZ58_14390	COG1609	Transcriptional regulator
KFZ58_14400	COG3835	regulator
KFZ58_14405	COG1929	Belongs to the glycerate kinase type-1 family
KFZ58_14420	COG3875	lactate racemase activity
KFZ58_14425	COG2610	gluconate transmembrane transporter activity
KFZ58_14440	COG1309	transcriptional regulator
KFZ58_14445	COG1250	3-hydroxyacyl-CoA dehydrogenase
KFZ58_14480	COG0583	DNA-binding transcription factor activity
KFZ58_14500	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
KFZ58_14520	COG1414	Transcriptional regulator
KFZ58_14525	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
KFZ58_14525	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
KFZ58_14565	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
KFZ58_14580	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
KFZ58_14580	COG3933	PFAM sigma-54 factor interaction domain-containing protein
KFZ58_14585	COG0747	negative chemotaxis
KFZ58_14590	COG0318	PFAM AMP-dependent synthetase and ligase
KFZ58_14595	COG1598	PFAM Uncharacterised protein family UPF0150
KFZ58_14615	COG3180	Ammonia monooxygenase
KFZ58_14620	COG5146	pantothenate kinase activity
KFZ58_14625	COG5146	pantothenate kinase activity
KFZ58_14630	COG0602	queuosine metabolic process
KFZ58_14635	COG0720	synthase
KFZ58_14640	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
KFZ58_14665	COG1160	GTP binding
KFZ58_14675	COG1757	Na H antiporter
KFZ58_14680	COG0788	formyltetrahydrofolate deformylase activity
KFZ58_14690	COG1902	pentaerythritol trinitrate reductase activity
KFZ58_14695	COG0584	glycerophosphoryl diester phosphodiesterase
KFZ58_14700	COG2356	endonuclease I
KFZ58_14715	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KFZ58_14725	COG2814	Major facilitator Superfamily
KFZ58_14735	COG0419	ATPase involved in DNA repair
KFZ58_14740	COG0420	3'-5' exonuclease activity
KFZ58_14755	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
KFZ58_14780	COG1404	Belongs to the peptidase S8 family
KFZ58_14805	COG2261	transglycosylase associated protein
KFZ58_14815	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
KFZ58_14825	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
KFZ58_14835	COG0681	Belongs to the peptidase S26 family
KFZ58_14860	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
KFZ58_14865	COG0668	transmembrane transport
KFZ58_14870	COG2112	serine threonine protein kinase
KFZ58_14890	COG0402	S-adenosylhomocysteine deaminase activity
KFZ58_14920	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KFZ58_14925	COG1957	nucleoside hydrolase
KFZ58_14940	COG1288	antiporter activity
KFZ58_14945	COG1473	amidohydrolase
KFZ58_14950	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
KFZ58_14960	COG2190	(PTS) system
KFZ58_14970	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KFZ58_14970	COG1263	PTS System
KFZ58_14985	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
KFZ58_15000	COG1012	belongs to the aldehyde dehydrogenase family
KFZ58_15030	COG1757	Na H antiporter
KFZ58_15065	COG1454	alcohol dehydrogenase
KFZ58_15070	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
KFZ58_15070	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
KFZ58_15075	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
KFZ58_15085	COG0583	DNA-binding transcription factor activity
KFZ58_15090	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
KFZ58_15100	COG2188	Transcriptional regulator
KFZ58_15120	COG2433	Pfam Transposase IS66
KFZ58_15125	COG1804	L-carnitine dehydratase bile acid-inducible protein F
KFZ58_15130	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
KFZ58_15135	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
KFZ58_15145	COG1802	Transcriptional regulator
KFZ58_15155	COG0066	3-isopropylmalate dehydratase activity
KFZ58_15165	COG4145	pantothenate transmembrane transporter activity
KFZ58_15195	COG1012	belongs to the aldehyde dehydrogenase family
KFZ58_15200	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
KFZ58_15205	COG2186	Transcriptional regulator
KFZ58_15220	COG1228	amidohydrolase
KFZ58_15250	COG1028	Short-chain dehydrogenase reductase Sdr
KFZ58_15260	COG1115	amino acid carrier protein
KFZ58_15270	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
KFZ58_15275	COG1012	belongs to the aldehyde dehydrogenase family
KFZ58_15280	COG1510	regulation of RNA biosynthetic process
KFZ58_15285	COG2113	Glycine betaine
KFZ58_15290	COG0579	oxidoreductase
KFZ58_15295	COG2186	Transcriptional regulator
KFZ58_15300	COG1620	l-lactate permease
KFZ58_15345	COG2188	Transcriptional regulator
KFZ58_15365	COG1082	Xylose isomerase domain protein TIM barrel
KFZ58_15370	COG0673	inositol 2-dehydrogenase activity
KFZ58_15380	COG1172	Belongs to the binding-protein-dependent transport system permease family
KFZ58_15385	COG1129	ABC transporter
KFZ58_15390	COG1879	ABC-type sugar transport system periplasmic component
KFZ58_15395	COG1609	Transcriptional regulator
KFZ58_15425	COG0084	hydrolase, TatD family'
KFZ58_15440	COG2133	pyrroloquinoline quinone binding
KFZ58_15450	COG1028	Short-chain dehydrogenase reductase Sdr
KFZ58_15460	COG2115	Belongs to the xylose isomerase family
KFZ58_15465	COG1070	Carbohydrate kinase
KFZ58_15470	COG0477	Major facilitator Superfamily
KFZ58_15470	COG2814	Major facilitator Superfamily
KFZ58_15520	COG0395	ABC-type sugar transport system, permease component
KFZ58_15600	COG1757	Na H antiporter
KFZ58_15605	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
KFZ58_15610	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
KFZ58_15615	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
KFZ58_15620	COG0179	Fumarylacetoacetate (FAA) hydrolase
KFZ58_15625	COG1802	Transcriptional regulator
KFZ58_15635	COG1757	Na H antiporter
KFZ58_15650	COG1757	Na H antiporter
KFZ58_15700	COG0463	Glycosyl transferase, family 2
KFZ58_15700	COG1216	Glycosyl transferase, family 2
KFZ58_15715	COG0438	transferase activity, transferring glycosyl groups
KFZ58_15760	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
KFZ58_15765	COG1210	Utp--glucose-1-phosphate uridylyltransferase
KFZ58_15775	COG2197	response regulator
KFZ58_15780	COG4464	protein tyrosine phosphatase activity
KFZ58_15790	COG4464	protein tyrosine phosphatase activity
KFZ58_15795	COG0489	protein tyrosine kinase activity
KFZ58_15800	COG3944	biosynthesis protein
KFZ58_15805	COG1388	LysM domain
KFZ58_15805	COG0791	NLP P60 protein
KFZ58_15850	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
KFZ58_15865	COG1785	Belongs to the alkaline phosphatase family
KFZ58_15875	COG0432	Pfam Uncharacterised protein family UPF0047
KFZ58_15890	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
KFZ58_15895	COG0246	Mannitol dehydrogenase
KFZ58_15910	COG3711	transcriptional antiterminator
KFZ58_15925	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
KFZ58_15930	COG1405	negative regulation of cell septum assembly
KFZ58_15930	COG3012	SEC-C Motif Domain Protein
KFZ58_15955	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
KFZ58_15965	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
KFZ58_15970	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
KFZ58_15975	COG1028	Short-chain dehydrogenase reductase Sdr
KFZ58_15985	COG5464	transposase or invertase
KFZ58_16005	COG1316	TRANSCRIPTIONal
KFZ58_16010	COG2188	Transcriptional regulator
KFZ58_16035	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KFZ58_16045	COG2207	Transcriptional regulator
KFZ58_16045	COG3708	Transcriptional regulator
KFZ58_16050	COG0531	amino acid
KFZ58_16055	COG2169	Transcriptional regulator
KFZ58_16060	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
KFZ58_16085	COG1028	Short-chain dehydrogenase reductase Sdr
KFZ58_16100	COG2113	Glycine betaine
KFZ58_16125	COG1349	DNA-binding transcription factor activity
KFZ58_16130	COG1105	Belongs to the carbohydrate kinase PfkB family
KFZ58_16135	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
KFZ58_16135	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KFZ58_16135	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KFZ58_16150	COG1316	TRANSCRIPTIONal
KFZ58_16155	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
KFZ58_16160	COG2318	DinB family
KFZ58_16165	COG2268	Band 7 protein
KFZ58_16170	COG1368	sulfuric ester hydrolase activity
KFZ58_16200	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
KFZ58_16225	COG4193	domain, Protein
KFZ58_16230	COG4193	domain, Protein
KFZ58_16235	COG0860	N-Acetylmuramoyl-L-alanine amidase
KFZ58_16240	COG0189	ligase activity
KFZ58_16240	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
KFZ58_16245	COG0189	ligase activity
KFZ58_16255	COG1794	racemase activity, acting on amino acids and derivatives
KFZ58_16265	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
KFZ58_16265	COG0189	ligase activity
KFZ58_16270	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
KFZ58_16270	COG1181	Belongs to the D-alanine--D-alanine ligase family
KFZ58_16275	COG0189	ligase activity
KFZ58_16275	COG2918	glutathione biosynthetic process
KFZ58_16285	COG0463	Glycosyl transferase, family 2
KFZ58_16290	COG0463	Glycosyl transferase, family 2
KFZ58_16300	COG1682	transport, permease protein
KFZ58_16305	COG1215	transferase activity, transferring glycosyl groups
KFZ58_16315	COG0438	transferase activity, transferring glycosyl groups
KFZ58_16320	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
KFZ58_16325	COG1210	Utp--glucose-1-phosphate uridylyltransferase
KFZ58_16335	COG3639	organic phosphonate transmembrane transporter activity
KFZ58_16340	COG3639	organic phosphonate transmembrane transporter activity
KFZ58_16345	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
KFZ58_16355	COG0613	PHP domain protein
KFZ58_16360	COG4778	phosphonate C-P lyase system protein PhnL
KFZ58_16365	COG3454	Phosphonate metabolism
KFZ58_16370	COG4107	phosphonate C-P lyase system protein PhnK
KFZ58_16375	COG3627	carbon phosphorus lyase activity
KFZ58_16395	COG2188	Transcriptional regulator
KFZ58_16415	COG0747	negative chemotaxis
KFZ58_16420	COG0471	metal ion transport
KFZ58_16430	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
KFZ58_16435	COG0405	Gamma-glutamyltransferase
KFZ58_16440	COG2027	D-alanyl-D-alanine carboxypeptidase
KFZ58_16445	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
KFZ58_16450	COG1472	Belongs to the glycosyl hydrolase 3 family
KFZ58_16485	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
KFZ58_16490	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
KFZ58_16500	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
KFZ58_16515	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
KFZ58_16530	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KFZ58_16540	COG1309	transcriptional regulator
KFZ58_16555	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
KFZ58_16570	COG4786	Flagellar basal body rod
KFZ58_16575	COG4786	Flagellar basal body rod
KFZ58_16580	COG1077	Cell shape determining protein MreB Mrl
KFZ58_16585	COG1609	Transcriptional regulator
KFZ58_16600	COG2385	sporulation resulting in formation of a cellular spore
KFZ58_16605	COG4608	Belongs to the ABC transporter superfamily
KFZ58_16610	COG0791	NLP P60 protein
KFZ58_16615	COG1619	proteins homologs of microcin C7 resistance protein MccF
KFZ58_16620	COG4166	transmembrane transport
KFZ58_16625	COG0444	Belongs to the ABC transporter superfamily
KFZ58_16630	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KFZ58_16635	COG0601	transmembrane transport
KFZ58_16640	COG2362	D-Aminopeptidase
KFZ58_16645	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
KFZ58_16655	COG4836	Membrane
KFZ58_16660	COG0355	proton-transporting ATP synthase activity, rotational mechanism
KFZ58_16670	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
KFZ58_16675	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
KFZ58_16680	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
KFZ58_16685	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
KFZ58_16690	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
KFZ58_16695	COG0356	it plays a direct role in the translocation of protons across the membrane
KFZ58_16705	COG1404	Belongs to the peptidase S8 family
KFZ58_16715	COG2076	Multidrug Resistance protein
KFZ58_16720	COG2076	Multidrug Resistance protein
KFZ58_16725	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
KFZ58_16730	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
KFZ58_16735	COG4475	Protein of unknown function (DUF436)
KFZ58_16740	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
KFZ58_16745	COG1971	Probably functions as a manganese efflux pump
KFZ58_16750	COG0009	L-threonylcarbamoyladenylate synthase
KFZ58_16770	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
KFZ58_16785	COG1435	thymidine kinase activity
KFZ58_16790	COG0254	rRNA binding
KFZ58_16795	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
KFZ58_16800	COG1494	fructose-1,6-bisphosphatase
KFZ58_16805	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
KFZ58_16810	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
KFZ58_16815	COG2204	response regulator
KFZ58_16820	COG0504	CTP synthase activity
KFZ58_16830	COG1703	isobutyryl-CoA mutase activity
KFZ58_16830	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
KFZ58_16830	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
KFZ58_16835	COG1309	transcriptional regulator
KFZ58_16845	COG1960	acyl-CoA dehydrogenase activity
KFZ58_16850	COG1960	acyl-CoA dehydrogenase activity
KFZ58_16855	COG1250	3-hydroxyacyl-CoA dehydrogenase
KFZ58_16860	COG0183	Belongs to the thiolase family
KFZ58_16865	COG0247	lactate metabolic process
KFZ58_16865	COG2181	nitrate reductase activity
KFZ58_16870	COG0018	arginyl-trna synthetase
KFZ58_16880	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KFZ58_16890	COG3465	dGTPase activity
KFZ58_16895	COG1078	dGTPase activity
KFZ58_16900	COG0095	Lipoate-protein ligase
KFZ58_16910	COG0280	phosphate acetyltransferase
KFZ58_16915	COG3253	May function as heme-dependent peroxidase
KFZ58_16925	COG2363	Small membrane protein
KFZ58_16945	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
KFZ58_16950	COG3314	Sporulation integral membrane protein YlbJ
KFZ58_16975	COG3594	Acyltransferase
KFZ58_16980	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
KFZ58_16985	COG1793	dna ligase
KFZ58_16985	COG3285	dna ligase
KFZ58_16995	COG1764	response to oxidative stress
KFZ58_17000	COG2076	Multidrug Resistance protein
KFZ58_17005	COG2076	Multidrug Resistance protein
KFZ58_17010	COG3226	Transcriptional regulator
KFZ58_17020	COG0469	pyruvate kinase activity
KFZ58_17045	COG3279	Response regulator of the LytR AlgR family
KFZ58_17055	COG2154	pterin-4-alpha-carbinolamine dehydratase
KFZ58_17060	COG0584	glycerophosphoryl diester phosphodiesterase
KFZ58_17065	COG0584	glycerophosphoryl diester phosphodiesterase
KFZ58_17080	COG1175	transmembrane transport
KFZ58_17085	COG3842	ATPase activity
KFZ58_17105	COG3189	MarR family transcriptional regulator
KFZ58_17125	COG0628	permease
KFZ58_17140	COG1114	Component of the transport system for branched-chain amino acids
KFZ58_17150	COG0514	ATP-dependent DNA helicase (RecQ)
KFZ58_17175	COG1619	proteins homologs of microcin C7 resistance protein MccF
KFZ58_17190	COG1619	proteins homologs of microcin C7 resistance protein MccF
KFZ58_17200	COG2807	transmembrane transport
KFZ58_17215	COG0586	Pfam SNARE associated Golgi protein
KFZ58_17220	COG0530	calcium, potassium:sodium antiporter activity
KFZ58_17245	COG1733	regulation of RNA biosynthetic process
KFZ58_17250	COG0010	Belongs to the arginase family
KFZ58_17255	COG1228	amidohydrolase
KFZ58_17260	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
KFZ58_17265	COG2986	histidine ammonia-lyase
KFZ58_17275	COG1607	acyl-coa hydrolase
KFZ58_17280	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
KFZ58_17285	COG0626	cystathionine gamma-synthase activity
KFZ58_17290	COG2962	Rard protein
KFZ58_17300	COG2873	o-acetylhomoserine
KFZ58_17305	COG2755	lipolytic protein G-D-S-L family
KFZ58_17320	COG0488	(ABC) transporter
KFZ58_17335	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
KFZ58_17345	COG1263	PTS System
KFZ58_17345	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KFZ58_17350	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
KFZ58_17390	COG3584	3D domain protein
KFZ58_17390	COG1388	LysM domain
KFZ58_17395	COG4086	secreted protein
KFZ58_17400	COG2814	Major facilitator Superfamily
KFZ58_17410	COG1979	alcohol dehydrogenase
KFZ58_17415	COG0251	oxidation-reduction process
KFZ58_17420	COG0741	lytic transglycosylase activity
KFZ58_17430	COG0534	Mate efflux family protein
KFZ58_17435	COG0318	PFAM AMP-dependent synthetase and ligase
KFZ58_17440	COG3328	transposase activity
KFZ58_17450	COG4608	Belongs to the ABC transporter superfamily
KFZ58_17455	COG0444	Belongs to the ABC transporter superfamily
KFZ58_17460	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KFZ58_17465	COG0601	transmembrane transport
KFZ58_17480	COG0747	negative chemotaxis
KFZ58_17485	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KFZ58_17490	COG0601	transmembrane transport
KFZ58_17495	COG0444	Belongs to the ABC transporter superfamily
KFZ58_17500	COG4608	Belongs to the ABC transporter superfamily
KFZ58_17515	COG2358	TRAP transporter, solute receptor (TAXI family
KFZ58_17530	COG2814	Major facilitator Superfamily
KFZ58_17545	COG2032	superoxide dismutase activity
KFZ58_17550	COG2315	Protein conserved in bacteria
KFZ58_17565	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
KFZ58_17570	COG1247	-acetyltransferase
KFZ58_17630	COG0069	glutamate synthase activity
KFZ58_17635	COG1476	TRANSCRIPTIONal
KFZ58_17645	COG2116	formate transmembrane transporter activity
KFZ58_17675	COG1562	ergosterol biosynthetic process
KFZ58_17680	COG1233	COG1233 Phytoene dehydrogenase and related
KFZ58_17700	COG0702	epimerase
KFZ58_17710	COG2155	Conserved Protein
KFZ58_17720	COG1136	(ABC) transporter
KFZ58_17725	COG0577	efflux transmembrane transporter activity
KFZ58_17755	COG1131	(ABC) transporter
KFZ58_17785	COG1120	ATPase activity
KFZ58_17795	COG4152	abc transporter atp-binding protein
KFZ58_17815	COG1574	metal-dependent hydrolase with the TIM-barrel fold
KFZ58_17820	COG1115	amino acid carrier protein
KFZ58_17825	COG3103	Sh3 type 3 domain protein
KFZ58_17825	COG4991	sh3 domain protein
KFZ58_17825	COG0860	N-Acetylmuramoyl-L-alanine amidase
KFZ58_17835	COG0702	epimerase
KFZ58_17840	COG1309	transcriptional regulator
KFZ58_17865	COG0431	NADPH-dependent FMN reductase
KFZ58_17875	COG1393	Belongs to the ArsC family
KFZ58_17880	COG0346	lactoylglutathione lyase activity
KFZ58_17885	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
KFZ58_17890	COG0346	lactoylglutathione lyase activity
KFZ58_17920	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
KFZ58_17930	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
KFZ58_17935	COG0583	DNA-binding transcription factor activity
KFZ58_17940	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
KFZ58_17955	COG3246	L-lysine catabolic process to acetate
KFZ58_17965	COG2323	membrane
KFZ58_17970	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
KFZ58_17985	COG1510	regulation of RNA biosynthetic process
KFZ58_18000	COG0753	catalase activity
KFZ58_18015	COG3655	Transcriptional regulator
KFZ58_18020	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
KFZ58_18025	COG0820	rRNA (adenine-C2-)-methyltransferase activity
KFZ58_18035	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KFZ58_18040	COG2124	cytochrome p450
KFZ58_18045	COG0655	NAD(P)H dehydrogenase (quinone) activity
KFZ58_18055	COG1320	monovalent cation:proton antiporter activity
KFZ58_18060	COG2212	antiporter activity
KFZ58_18065	COG1863	multisubunit Na H antiporter MnhE subunit
KFZ58_18070	COG0651	ATP synthesis coupled electron transport
KFZ58_18075	COG1006	Multisubunit Na H antiporter MnhC subunit
KFZ58_18080	COG2111	Na H antiporter
KFZ58_18085	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
KFZ58_18085	COG2111	Na H antiporter
KFZ58_18095	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
KFZ58_18130	COG1252	NADH dehydrogenase
KFZ58_18160	COG1695	Transcriptional regulator
KFZ58_18165	COG2197	response regulator
KFZ58_18170	COG4585	Histidine kinase
KFZ58_18175	COG3239	Fatty acid desaturase
KFZ58_18180	COG2814	Major facilitator Superfamily
KFZ58_18185	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
KFZ58_18190	COG0573	inorganic phosphate transmembrane transporter activity
KFZ58_18195	COG0581	inorganic phosphate transmembrane transporter activity
KFZ58_18200	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
KFZ58_18205	COG0710	3-dehydroquinate dehydratase activity
KFZ58_18215	COG3853	Toxic anion resistance protein (TelA)
KFZ58_18220	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
KFZ58_18230	COG0702	epimerase
KFZ58_18250	COG1231	oxidoreductase activity
KFZ58_18255	COG2311	Membrane
KFZ58_18270	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
KFZ58_18275	COG0583	DNA-binding transcription factor activity
KFZ58_18290	COG1346	cytolysis
KFZ58_18295	COG1380	Effector of murein hydrolase LrgA
KFZ58_18330	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
KFZ58_18335	COG3871	stress protein (general stress protein 26)
KFZ58_18350	COG1757	Na H antiporter
KFZ58_18355	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
KFZ58_18370	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
KFZ58_18375	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
KFZ58_18385	COG2723	6-phospho-beta-galactosidase activity
KFZ58_18390	COG0561	phosphatase activity
KFZ58_18395	COG3949	Membrane
KFZ58_18400	COG0431	NADPH-dependent FMN reductase
KFZ58_18410	COG1393	Belongs to the ArsC family
KFZ58_18415	COG1309	transcriptional regulator
KFZ58_18420	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
KFZ58_18425	COG1442	glycosyl transferase family 8
KFZ58_18430	COG4536	flavin adenine dinucleotide binding
KFZ58_18435	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
KFZ58_18440	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
KFZ58_18445	COG0640	Transcriptional regulator
KFZ58_18490	COG1301	dicarboxylic acid transport
KFZ58_18520	COG2719	SpoVR family
KFZ58_18530	COG2718	Belongs to the UPF0229 family
KFZ58_18535	COG2766	serine protein kinase
KFZ58_18540	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
KFZ58_18550	COG2270	Major facilitator Superfamily
KFZ58_18570	COG2706	6-phosphogluconolactonase activity
KFZ58_18575	COG0681	Belongs to the peptidase S26 family
KFZ58_18625	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
KFZ58_18635	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
KFZ58_18645	COG1489	DNA binding
KFZ58_18660	COG0579	oxidoreductase
KFZ58_18710	COG0402	S-adenosylhomocysteine deaminase activity
KFZ58_18715	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
KFZ58_18730	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
KFZ58_18735	COG3973	AAA domain
KFZ58_18750	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
KFZ58_18760	COG1028	Short-chain dehydrogenase reductase Sdr
KFZ58_18785	COG2027	D-alanyl-D-alanine carboxypeptidase
KFZ58_18800	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KFZ58_18805	COG2828	Protein conserved in bacteria
KFZ58_18810	COG1028	Short-chain dehydrogenase reductase Sdr
KFZ58_18815	COG1028	Short-chain dehydrogenase reductase Sdr
KFZ58_18820	COG2304	oxidoreductase activity
KFZ58_18825	COG3227	Zinc metalloprotease (Elastase)
KFZ58_18835	COG0406	alpha-ribazole phosphatase activity
KFZ58_18845	COG1028	Short-chain dehydrogenase reductase Sdr
KFZ58_18855	COG2154	pterin-4-alpha-carbinolamine dehydratase
KFZ58_18860	COG1132	(ABC) transporter
KFZ58_18870	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KFZ58_18875	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
KFZ58_18880	COG4863	YycH protein
KFZ58_18885	COG5002	protein histidine kinase activity
KFZ58_18890	COG0745	RESPONSE REGULATOR receiver
KFZ58_18895	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
KFZ58_18930	COG2807	transmembrane transport
KFZ58_18935	COG0305	Participates in initiation and elongation during chromosome replication
KFZ58_18940	COG0359	binds to the 23S rRNA
KFZ58_18945	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
KFZ58_18950	COG4241	membrane
KFZ58_18960	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
KFZ58_18965	COG0629	single-stranded DNA binding
KFZ58_18970	COG0360	Binds together with S18 to 16S ribosomal RNA
KFZ58_18975	COG0012	GTP binding
KFZ58_18980	COG4481	Protein conserved in bacteria
KFZ58_18985	COG0668	transmembrane transport
KFZ58_18990	COG3949	Membrane
KFZ58_19010	COG1475	DNA binding
KFZ58_19015	COG1192	Involved in chromosome partitioning
KFZ58_19020	COG1475	DNA binding
KFZ58_19025	COG0357	Ribosomal RNA small subunit methyltransferase G
KFZ58_19030	COG0445	tRNA wobble uridine modification
KFZ58_19035	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
KFZ58_19045	COG1847	R3H domain protein
KFZ58_19050	COG0706	membrane insertase activity
KFZ58_19055	COG0594	ribonuclease P activity
KFZ58_19060	COG0230	Belongs to the bacterial ribosomal protein bL34 family