locus-tag	class	description
X953_00005	COG0592	DNA-directed DNA polymerase activity
X953_00010	COG2501	S4 domain
X953_00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
X953_00025	COG0187	DNA topoisomerase II activity
X953_00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
X953_00035	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
X953_00050	COG0517	IMP dehydrogenase activity
X953_00050	COG0516	GMP reductase activity
X953_00060	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
X953_00065	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
X953_00070	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
X953_00080	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
X953_00085	COG2011	ABC-type metal ion transport system permease component
X953_00090	COG1464	Belongs to the NlpA lipoprotein family
X953_00110	COG2357	RelA SpoT domain protein
X953_00115	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
X953_00120	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
X953_00125	COG1428	Deoxynucleoside kinase
X953_00130	COG1428	Deoxynucleoside kinase
X953_00140	COG1301	dicarboxylic acid transport
X953_00150	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
X953_00155	COG3425	synthase
X953_00160	COG1017	nitric oxide dioxygenase activity
X953_00160	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
X953_00165	COG1959	2 iron, 2 sulfur cluster binding
X953_00170	COG0693	protein deglycase activity
X953_00175	COG3858	chitin binding
X953_00175	COG1388	LysM domain
X953_00180	COG1335	isochorismatase
X953_00185	COG0590	tRNA wobble adenosine to inosine editing
X953_00195	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
X953_00200	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
X953_00205	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
X953_00225	COG1982	Orn Lys Arg decarboxylase major
X953_00230	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
X953_00235	COG3870	Protein conserved in bacteria
X953_00240	COG1728	Protein conserved in bacteria
X953_00245	COG0470	DNA polymerase III
X953_00250	COG1774	PSP1 C-terminal conserved region
X953_00255	COG4467	Involved in initiation control of chromosome replication
X953_00260	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
X953_00265	COG2827	Endonuclease containing a URI domain
X953_00270	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
X953_00280	COG2002	toxin-antitoxin pair type II binding
X953_00290	COG0084	hydrolase, TatD family'
X953_00295	COG3584	3D domain protein
X953_00295	COG3583	domain protein
X953_00305	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
X953_00310	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
X953_00320	COG4466	Protein conserved in bacteria
X953_00330	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
X953_00335	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
X953_00340	COG2088	sporulation resulting in formation of a cellular spore
X953_00345	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
X953_00350	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
X953_00355	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
X953_00360	COG0193	aminoacyl-tRNA hydrolase activity
X953_00370	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
X953_00375	COG2002	toxin-antitoxin pair type II binding
X953_00380	COG2244	polysaccharide biosynthetic process
X953_00385	COG3956	TIGRFAM MazG family protein
X953_00390	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
X953_00415	COG1098	S1 RNA binding domain
X953_00425	COG2208	phosphoserine phosphatase activity
X953_00430	COG2304	oxidoreductase activity
X953_00435	COG0515	serine threonine protein kinase
X953_00440	COG0037	tRNA processing
X953_00450	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
X953_00460	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
X953_00465	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
X953_00470	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
X953_00480	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
X953_00490	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
X953_00495	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
X953_00500	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
X953_00505	COG1396	sequence-specific DNA binding
X953_00510	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
X953_00530	COG1285	pathogenesis
X953_00540	COG3880	PFAM UvrB UvrC protein
X953_00545	COG3869	Catalyzes the specific phosphorylation of arginine residues in
X953_00550	COG0542	response to heat
X953_00560	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
X953_00565	COG4956	integral membrane protein (PIN domain superfamily)
X953_00570	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
X953_00575	COG1045	serine acetyltransferase
X953_00580	COG0215	cysteine-tRNA ligase activity
X953_00590	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
X953_00595	COG3688	RNA-binding protein containing a PIN domain
X953_00605	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
X953_00610	COG0250	Participates in transcription elongation, termination and antitermination
X953_00615	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
X953_00620	COG0081	regulation of translation
X953_00625	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
X953_00635	COG2813	Specifically methylates the guanine in position
X953_00640	COG0085	RNA polymerase activity
X953_00645	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
X953_00650	COG1358	cellular component organization or biogenesis
X953_00655	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
X953_00660	COG0049	tRNA binding
X953_00665	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
X953_00670	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
X953_00675	COG0051	transcription antitermination factor activity, RNA binding
X953_00680	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
X953_00685	COG0088	Forms part of the polypeptide exit tunnel
X953_00690	COG0089	rRNA binding
X953_00695	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
X953_00700	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
X953_00705	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
X953_00710	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
X953_00715	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
X953_00720	COG0255	Belongs to the universal ribosomal protein uL29 family
X953_00725	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
X953_00730	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
X953_00735	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
X953_00740	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
X953_00745	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
X953_00750	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
X953_00755	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
X953_00760	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
X953_00765	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
X953_00770	COG1841	ribosomal large subunit assembly
X953_00775	COG0200	Binds to the 23S rRNA
X953_00780	COG0201	protein transport
X953_00785	COG0563	adenylate kinase activity
X953_00790	COG2163	COG2163 Ribosomal protein L14E L6E L27E
X953_00795	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
X953_00800	COG0257	Belongs to the bacterial ribosomal protein bL36 family
X953_00805	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
X953_00810	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
X953_00815	COG0202	RNA polymerase activity
X953_00820	COG0203	ribosomal protein L17
X953_00830	COG1122	ATPase activity
X953_00835	COG1122	ATPase activity
X953_00845	COG0101	tRNA pseudouridine synthase activity
X953_00850	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
X953_00855	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
X953_00955	COG0028	Belongs to the TPP enzyme family
X953_00960	COG0028	Belongs to the TPP enzyme family
X953_00965	COG1346	cytolysis
X953_00975	COG0583	DNA-binding transcription factor activity
X953_00980	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
X953_01025	COG0714	Associated with various cellular activities
X953_01030	COG4548	von Willebrand factor, type A
X953_01055	COG1295	ribonuclease BN
X953_01080	COG0860	N-Acetylmuramoyl-L-alanine amidase
X953_01085	COG0489	protein tyrosine kinase activity
X953_01095	COG2194	sulfuric ester hydrolase activity
X953_01100	COG0726	polysaccharide deacetylase
X953_01155	COG0494	nUDIX hydrolase
X953_01165	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
X953_01170	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
X953_01250	COG1595	DNA-templated transcription, initiation
X953_01255	COG5662	AntiSigma factor
X953_01260	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
X953_01265	COG4856	YbbR-like protein
X953_01270	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
X953_01275	COG0745	RESPONSE REGULATOR receiver
X953_01280	COG3850	Histidine kinase
X953_01280	COG5002	protein histidine kinase activity
X953_01285	COG0577	efflux transmembrane transporter activity
X953_01315	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
X953_01355	COG0840	transmembrane signaling receptor activity
X953_01370	COG3706	GGDEF domain
X953_01460	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
X953_01550	COG0084	hydrolase, TatD family'
X953_01655	COG3706	GGDEF domain
X953_01745	COG4974	Belongs to the 'phage' integrase family
X953_01770	COG2072	flavoprotein involved in K transport
X953_01810	COG0732	type I restriction modification DNA specificity domain
X953_01855	COG1484	DNA-dependent DNA replication
X953_01910	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
X953_01915	COG1801	Protein of unknown function DUF72
X953_01925	COG0488	(ABC) transporter
X953_01930	COG3011	Protein conserved in bacteria
X953_01945	COG3706	GGDEF domain
X953_01945	COG0745	RESPONSE REGULATOR receiver
X953_01955	COG1271	oxidase subunit
X953_01960	COG1294	oxidase, subunit
X953_01965	COG4988	ABC transporter
X953_01970	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
X953_01980	COG1309	transcriptional regulator
X953_01985	COG1131	(ABC) transporter
X953_02010	COG0243	molybdopterin cofactor binding
X953_02040	COG2223	nitrite transmembrane transporter activity
X953_02050	COG2197	response regulator
X953_02060	COG4585	Histidine kinase
X953_02070	COG1028	Short-chain dehydrogenase reductase Sdr
X953_02075	COG1114	Component of the transport system for branched-chain amino acids
X953_02080	COG1802	Transcriptional regulator
X953_02085	COG0753	catalase activity
X953_02095	COG0668	transmembrane transport
X953_02115	COG1413	lyase activity
X953_02125	COG1607	acyl-coa hydrolase
X953_02135	COG2124	cytochrome p450
X953_02140	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
X953_02145	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
X953_02155	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
X953_02160	COG0460	homoserine dehydrogenase
X953_02175	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
X953_02180	COG2814	Major facilitator Superfamily
X953_02195	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
X953_02220	COG0589	response to stress
X953_02225	COG2855	membrane
X953_02235	COG0789	Transcriptional regulator
X953_02240	COG0352	thiamine-phosphate diphosphorylase activity
X953_02245	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
X953_02260	COG1063	alcohol dehydrogenase
X953_02280	COG4145	pantothenate transmembrane transporter activity
X953_02290	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
X953_02300	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
X953_02305	COG5506	Protein of unknown function (DUF1694)
X953_02320	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
X953_02330	COG5577	PFAM Coat F domain
X953_02345	COG0708	Exodeoxyribonuclease III
X953_02350	COG1725	Transcriptional regulator
X953_02355	COG1131	(ABC) transporter
X953_02370	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
X953_02390	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
X953_02395	COG0095	Lipoate-protein ligase
X953_02405	COG0159	tryptophan synthase activity
X953_02410	COG0133	tryptophan synthase activity
X953_02415	COG0135	phosphoribosylanthranilate isomerase activity
X953_02420	COG0134	indole-3-glycerol-phosphate synthase activity
X953_02425	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
X953_02430	COG0512	Glutamine amidotransferase of anthranilate synthase
X953_02435	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
X953_02445	COG1181	Belongs to the D-alanine--D-alanine ligase family
X953_02450	COG1115	amino acid carrier protein
X953_02455	COG0778	Nitroreductase
X953_02475	COG1418	mRNA catabolic process
X953_02480	COG1876	peptidase activity
X953_02485	COG2814	Major facilitator Superfamily
X953_02490	COG4166	transmembrane transport
X953_02495	COG1970	mechanosensitive ion channel activity
X953_02515	COG0519	Catalyzes the synthesis of GMP from XMP
X953_02520	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
X953_02525	COG1268	BioY protein
X953_02530	COG0840	transmembrane signaling receptor activity
X953_02540	COG0154	amidase activity
X953_02545	COG0656	L-ascorbic acid biosynthetic process
X953_02560	COG1304	FMN binding
X953_02565	COG4876	unkown
X953_02570	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
X953_02575	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
X953_02580	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
X953_02585	COG4605	iron ion homeostasis
X953_02590	COG4604	ABC transporter, ATP-binding protein
X953_02595	COG4607	ABC-type enterochelin transport system periplasmic component
X953_02600	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
X953_02605	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
X953_02610	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
X953_02610	COG0140	phosphoribosyl-ATP diphosphatase activity
X953_02615	COG0107	imidazoleglycerol-phosphate synthase activity
X953_02620	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
X953_02625	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
X953_02630	COG0131	Imidazoleglycerol-phosphate dehydratase
X953_02635	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
X953_02640	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
X953_02645	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
X953_02650	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
X953_02655	COG2832	Protein of unknown function (DUF454)
X953_02665	COG0812	UDP-N-acetylmuramate dehydrogenase activity
X953_02670	COG1126	abc transporter atp-binding protein
X953_02675	COG0765	amino acid transport
X953_02680	COG0765	amino acid transport
X953_02690	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
X953_02700	COG0673	inositol 2-dehydrogenase activity
X953_02705	COG1876	peptidase activity
X953_02710	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
X953_02715	COG2839	Protein conserved in bacteria
X953_02720	COG0351	phosphomethylpyrimidine kinase
X953_02725	COG1335	isochorismatase
X953_02735	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
X953_02745	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
X953_02750	COG0765	amino acid transport
X953_02755	COG1126	abc transporter atp-binding protein
X953_02760	COG0714	Associated with various cellular activities
X953_02765	COG0386	Belongs to the glutathione peroxidase family
X953_02770	COG3949	Membrane
X953_02780	COG0686	Belongs to the AlaDH PNT family
X953_02805	COG1278	Cold shock
X953_02815	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
X953_02825	COG2084	Dehydrogenase
X953_02835	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
X953_02840	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
X953_02845	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
X953_02850	COG0745	RESPONSE REGULATOR receiver
X953_02855	COG3850	Histidine kinase
X953_02855	COG5002	protein histidine kinase activity
X953_02865	COG1834	amidinotransferase
X953_02870	COG3403	YqcI/YcgG family
X953_02875	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
X953_02880	COG1131	(ABC) transporter
X953_02890	COG0183	Belongs to the thiolase family
X953_02910	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
X953_02920	COG0745	RESPONSE REGULATOR receiver
X953_02925	COG3850	Histidine kinase
X953_02925	COG5002	protein histidine kinase activity
X953_02935	COG1597	lipid kinase activity
X953_02945	COG1846	Transcriptional regulator
X953_02980	COG0513	Belongs to the DEAD box helicase family
X953_02985	COG0705	Rhomboid family
X953_02990	COG0736	holo-[acyl-carrier-protein] synthase activity
X953_02995	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
X953_02995	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
X953_03000	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
X953_03005	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
X953_03015	COG2337	Toxic component of a toxin-antitoxin (TA) module
X953_03025	COG1366	Belongs to the anti-sigma-factor antagonist family
X953_03030	COG2172	sigma factor antagonist activity
X953_03035	COG2208	phosphoserine phosphatase activity
X953_03040	COG1366	Belongs to the anti-sigma-factor antagonist family
X953_03045	COG2172	sigma factor antagonist activity
X953_03050	COG1191	sigma factor activity
X953_03055	COG2208	phosphoserine phosphatase activity
X953_03060	COG2183	response to ionizing radiation
X953_03065	COG0753	catalase activity
X953_03070	COG3091	SprT-like family
X953_03160	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
X953_03165	COG0802	atpase or kinase
X953_03170	COG1214	PFAM Peptidase M22, glycoprotease
X953_03175	COG0456	acetyltransferase
X953_03180	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
X953_03185	COG0772	Belongs to the SEDS family
X953_03190	COG0488	(ABC) transporter
X953_03200	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
X953_03210	COG1266	CAAX protease self-immunity
X953_03215	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
X953_03220	COG0459	protein refolding
X953_03225	COG0582	viral genome integration into host DNA
X953_03285	COG4372	Transposase
X953_03300	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
X953_03320	COG4873	Protein conserved in bacteria
X953_03335	COG4978	Transcriptional regulator
X953_03335	COG0789	Transcriptional regulator
X953_03340	COG0456	acetyltransferase
X953_03345	COG1309	transcriptional regulator
X953_03350	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
X953_03355	COG0390	transport system, permease component
X953_03360	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
X953_03370	COG0745	RESPONSE REGULATOR receiver
X953_03375	COG2205	protein histidine kinase activity
X953_03380	COG1136	(ABC) transporter
X953_03385	COG0577	efflux transmembrane transporter activity
X953_03390	COG0668	transmembrane transport
X953_03395	COG0697	spore germination
X953_03420	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
X953_03445	COG0714	Associated with various cellular activities
X953_03450	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
X953_03455	COG1305	Transglutaminase-like
X953_03460	COG0519	Catalyzes the synthesis of GMP from XMP
X953_03460	COG0518	GMP synthase (glutamine-hydrolyzing) activity
X953_03470	COG2252	PERMEase
X953_03480	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
X953_03485	COG2258	MOSC domain
X953_03495	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
X953_03500	COG1028	Short-chain dehydrogenase reductase Sdr
X953_03505	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
X953_03510	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
X953_03515	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
X953_03520	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
X953_03525	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
X953_03530	COG0047	phosphoribosylformylglycinamidine synthase activity
X953_03535	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
X953_03540	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
X953_03545	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
X953_03550	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
X953_03555	COG0138	bifunctional purine biosynthesis protein purh
X953_03560	COG0151	Belongs to the GarS family
X953_03565	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
X953_03570	COG1470	cell adhesion involved in biofilm formation
X953_03575	COG4496	protein, YerC YecD
X953_03580	COG0084	hydrolase, TatD family'
X953_03590	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
X953_03595	COG0210	DNA helicase
X953_03600	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
X953_03605	COG4851	CamS sex pheromone cAM373 precursor
X953_03610	COG1012	belongs to the aldehyde dehydrogenase family
X953_03625	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
X953_03630	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
X953_03635	COG0154	amidase activity
X953_03640	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
X953_03645	COG1597	lipid kinase activity
X953_03650	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
X953_03665	COG0109	protoheme IX farnesyltransferase activity
X953_03680	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
X953_03690	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
X953_03700	COG4499	WXG100 protein secretion system (Wss), protein YukC
X953_03700	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
X953_03705	COG1278	Cold shock
X953_03710	COG3328	transposase activity
X953_03715	COG0109	protoheme IX farnesyltransferase activity
X953_03725	COG0166	Belongs to the GPI family
X953_03740	COG0778	Nitroreductase
X953_03745	COG0564	pseudouridine synthase activity
X953_03760	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
X953_03770	COG0488	(ABC) transporter
X953_03795	COG0446	pyridine nucleotide-disulphide oxidoreductase
X953_03800	COG0733	neurotransmitter:sodium symporter activity
X953_03805	COG1757	Na H antiporter
X953_03810	COG0436	Aminotransferase
X953_03815	COG0028	Belongs to the TPP enzyme family
X953_03820	COG1012	belongs to the aldehyde dehydrogenase family
X953_03830	COG1414	Transcriptional regulator
X953_03840	COG1012	belongs to the aldehyde dehydrogenase family
X953_03850	COG1804	L-carnitine dehydratase bile acid-inducible protein F
X953_03855	COG1077	Cell shape determining protein MreB Mrl
X953_03860	COG2340	Cysteine-rich secretory protein family
X953_03865	COG2066	Belongs to the glutaminase family
X953_03870	COG2135	peptidase activity
X953_03875	COG1115	amino acid carrier protein
X953_03885	COG1295	ribonuclease BN
X953_03890	COG2217	Heavy metal translocating P-type atpase
X953_03895	COG0477	Major facilitator Superfamily
X953_03915	COG2056	Na+-H+ antiporter family
X953_03925	COG5002	protein histidine kinase activity
X953_03925	COG5001	Diguanylate cyclase
X953_03925	COG3447	MASE1 domain protein
X953_03935	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
X953_03940	COG0542	response to heat
X953_03945	COG0658	competence protein
X953_03945	COG2333	competence protein COMEC
X953_03950	COG2186	Transcriptional regulator
X953_03955	COG1131	(ABC) transporter
X953_03965	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
X953_03970	COG1131	(ABC) transporter
X953_03985	COG2188	Transcriptional regulator
X953_04010	COG1090	epimerase
X953_04015	COG2137	regulation of response to DNA damage stimulus
X953_04030	COG1988	membrane-bound metal-dependent
X953_04050	COG3557	Belongs to the UPF0374 family
X953_04055	COG1132	(ABC) transporter
X953_04060	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
X953_04070	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
X953_04075	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
X953_04080	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
X953_04085	COG0735	belongs to the Fur family
X953_04095	COG0512	Glutamine amidotransferase of anthranilate synthase
X953_04220	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
X953_04245	COG0424	maF-like protein
X953_04255	COG1733	regulation of RNA biosynthetic process
X953_04265	COG0431	NADPH-dependent FMN reductase
X953_04270	COG2364	Membrane
X953_04285	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
X953_04295	COG1227	inorganic diphosphatase activity
X953_04315	COG4474	Belongs to the UPF0398 family
X953_04345	COG0456	acetyltransferase
X953_04350	COG1794	racemase activity, acting on amino acids and derivatives
X953_04370	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
X953_04380	COG0519	Catalyzes the synthesis of GMP from XMP
X953_04405	COG4842	Belongs to the WXG100 family
X953_04410	COG5417	Belongs to the EsaB family
X953_04415	COG4499	WXG100 protein secretion system (Wss), protein YukC
X953_04420	COG0433	COG0433 Predicted ATPase
X953_04420	COG1674	ftsk spoiiie
X953_04425	COG1511	domain protein
X953_04445	COG5444	nuclease activity
X953_04490	COG5444	nuclease activity
X953_04565	COG2814	Major facilitator Superfamily
X953_04570	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
X953_04575	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
X953_04580	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
X953_04595	COG4166	transmembrane transport
X953_04600	COG0277	FAD linked oxidase domain protein
X953_04610	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
X953_04620	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
X953_04640	COG1714	RDD family
X953_04645	COG2176	DNA-directed DNA polymerase activity
X953_04650	COG0616	signal peptide processing
X953_04655	COG1714	RDD family
X953_04660	COG0318	PFAM AMP-dependent synthetase and ligase
X953_04690	COG2233	PERMEase
X953_04695	COG2814	Major facilitator Superfamily
X953_04715	COG0604	alcohol dehydrogenase
X953_04730	COG3320	Male sterility
X953_04730	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
X953_04755	COG2318	DinB family
X953_04765	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
X953_04770	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
X953_04775	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
X953_04780	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
X953_04785	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
X953_04790	COG4946	Tricorn protease homolog
X953_04790	COG0823	Involved in the tonB-independent uptake of proteins
X953_04790	COG1506	peptidase
X953_04825	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
X953_04835	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
X953_04850	COG0508	dehydrogenase complex catalyzes the overall conversion of
X953_04855	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
X953_04860	COG1012	belongs to the aldehyde dehydrogenase family
X953_04865	COG0534	Mate efflux family protein
X953_04870	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
X953_04890	COG0288	reversible hydration of carbon dioxide
X953_04900	COG1132	(ABC) transporter
X953_04905	COG1132	(ABC) transporter
X953_04910	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
X953_04925	COG1191	sigma factor activity
X953_04950	COG1854	S-ribosylhomocysteine lyase activity
X953_04960	COG0626	cystathionine gamma-synthase activity
X953_04965	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
X953_04970	COG1028	Short-chain dehydrogenase reductase Sdr
X953_04990	COG1131	(ABC) transporter
X953_04995	COG0024	Methionine aminopeptidase
X953_05010	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
X953_05020	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
X953_05030	COG2270	Major facilitator Superfamily
X953_05040	COG0114	fumarate hydratase activity
X953_05050	COG3842	ATPase activity
X953_05055	COG2508	Transcriptional regulator
X953_05060	COG3679	Belongs to the UPF0342 family
X953_05065	COG1024	Enoyl-CoA hydratase
X953_05075	COG4152	abc transporter atp-binding protein
X953_05080	COG1668	transmembrane transport
X953_05090	COG0420	3'-5' exonuclease activity
X953_05095	COG4717	serine-type aminopeptidase activity
X953_05100	COG1510	regulation of RNA biosynthetic process
X953_05105	COG3481	metal-dependent phosphohydrolase, HD sub domain
X953_05115	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
X953_05135	COG1510	regulation of RNA biosynthetic process
X953_05140	COG0517	IMP dehydrogenase activity
X953_05140	COG4175	Glycine betaine
X953_05160	COG4980	gas vesicle protein
X953_05170	COG0537	adenosine 5'-monophosphoramidase activity
X953_05175	COG1131	(ABC) transporter
X953_05180	COG4473	ABC transporter
X953_05185	COG1473	amidohydrolase
X953_05190	COG2193	ferroxidase activity
X953_05200	COG2814	Major facilitator Superfamily
X953_05210	COG4585	Histidine kinase
X953_05215	COG2197	response regulator
X953_05225	COG2329	Antibiotic biosynthesis monooxygenase
X953_05230	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
X953_05235	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
X953_05250	COG1164	Oligoendopeptidase f
X953_05260	COG1234	tRNA 3'-trailer cleavage
X953_05265	COG0095	Lipoate-protein ligase
X953_05270	COG0318	PFAM AMP-dependent synthetase and ligase
X953_05285	COG0398	Pfam SNARE associated Golgi protein
X953_05295	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
X953_05300	COG1074	ATP-dependent DNA helicase activity
X953_05310	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
X953_05315	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
X953_05360	COG2311	Membrane
X953_05365	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
X953_05385	COG1028	Short-chain dehydrogenase reductase Sdr
X953_05395	COG1307	EDD domain protein, DegV family
X953_05400	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
X953_05425	COG0561	phosphatase activity
X953_05430	COG1073	alpha beta
X953_05435	COG2151	metal-sulfur cluster biosynthetic enzyme
X953_05445	COG0314	molybdopterin synthase activity
X953_05455	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
X953_05470	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
X953_05495	COG1744	ABC transporter substrate-binding protein PnrA-like
X953_05500	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
X953_05505	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
X953_05520	COG0180	Tryptophanyl-tRNA synthetase
X953_05530	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
X953_05535	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
X953_05540	COG1116	anion transmembrane transporter activity
X953_05545	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
X953_05550	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
X953_05555	COG1388	LysM domain
X953_05565	COG0456	acetyltransferase
X953_05570	COG1393	Belongs to the ArsC family
X953_05575	COG4862	establishment of competence for transformation
X953_05585	COG1164	Oligoendopeptidase f
X953_05595	COG2346	COG2346, Truncated hemoglobins
X953_05600	COG4116	CYTH
X953_05605	COG2357	RelA SpoT domain protein
X953_05610	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
X953_05615	COG0564	pseudouridine synthase activity
X953_05620	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
X953_05625	COG2239	Acts as a magnesium transporter
X953_05655	COG2323	membrane
X953_05660	COG2153	protein acetylation
X953_05665	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
X953_05670	COG2382	esterase
X953_05675	COG1132	(ABC) transporter
X953_05680	COG1132	(ABC) transporter
X953_05700	COG0803	Belongs to the bacterial solute-binding protein 9 family
X953_05700	COG3443	Belongs to the bacterial solute-binding protein 9 family
X953_05735	COG0436	Aminotransferase
X953_05755	COG0584	glycerophosphoryl diester phosphodiesterase
X953_05800	COG2885	chlorophyll binding
X953_05800	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
X953_05810	COG3729	General stress protein
X953_05815	COG0488	(ABC) transporter
X953_05830	COG3328	transposase activity
X953_05835	COG2130	NADP-dependent
X953_05850	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
X953_05860	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
X953_05875	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
X953_05880	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
X953_05885	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
X953_05890	COG0297	glycogen (starch) synthase activity
X953_05895	COG0697	spore germination
X953_05940	COG0579	oxidoreductase
X953_06015	COG2309	aminopeptidase activity
X953_06020	COG1366	Belongs to the anti-sigma-factor antagonist family
X953_06055	COG0586	Pfam SNARE associated Golgi protein
X953_06065	COG1714	RDD family
X953_06090	COG1051	belongs to the nudix hydrolase family
X953_06115	COG1525	nuclease
X953_06125	COG0662	Cupin 2, conserved barrel domain protein
X953_06135	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
X953_06135	COG0456	acetyltransferase
X953_06175	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
X953_06180	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
X953_06185	COG1120	ATPase activity
X953_06190	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
X953_06195	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
X953_06205	COG1492	cobalamin metabolic process
X953_06210	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
X953_06215	COG0588	phosphoglycerate mutase activity
X953_06225	COG2096	Adenosyltransferase
X953_06250	COG1473	amidohydrolase
X953_06275	COG0653	protein targeting
X953_06285	COG0477	Major facilitator Superfamily
X953_06370	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
X953_06440	COG0596	Alpha beta hydrolase
X953_06500	COG1247	-acetyltransferase
X953_06590	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
X953_06590	COG0456	acetyltransferase
X953_06620	COG3961	Belongs to the TPP enzyme family
X953_06640	COG0346	lactoylglutathione lyase activity
X953_06650	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
X953_06705	COG1266	CAAX protease self-immunity
X953_06720	COG2226	methyltransferase
X953_06765	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
X953_06770	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
X953_06775	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
X953_06780	COG1268	BioY protein
X953_06810	COG1028	Short-chain dehydrogenase reductase Sdr
X953_06910	COG2807	transmembrane transport
X953_06915	COG2186	Transcriptional regulator
X953_06930	COG0745	RESPONSE REGULATOR receiver
X953_06945	COG2205	protein histidine kinase activity
X953_06970	COG2353	YceI-like domain
X953_06980	COG0346	lactoylglutathione lyase activity
X953_06985	COG0346	lactoylglutathione lyase activity
X953_06990	COG1846	Transcriptional regulator
X953_06995	COG0726	polysaccharide deacetylase
X953_07010	COG0456	acetyltransferase
X953_07060	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
X953_07065	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
X953_07070	COG2376	Dihydroxyacetone kinase
X953_07075	COG1461	Dihydroxyacetone kinase
X953_07080	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
X953_07120	COG3279	Response regulator of the LytR AlgR family
X953_07125	COG1695	Transcriptional regulator
X953_07135	COG0535	radical SAM domain protein
X953_07145	COG2169	Transcriptional regulator
X953_07150	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
X953_07155	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
X953_07170	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
X953_07200	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
X953_07200	COG3408	Glycogen debranching enzyme
X953_07220	COG2031	fatty acid transporter
X953_07240	COG0494	nUDIX hydrolase
X953_07245	COG1061	Type III restriction enzyme res subunit
X953_07250	COG1061	Type III restriction enzyme res subunit
X953_07260	COG1012	belongs to the aldehyde dehydrogenase family
X953_07285	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
X953_07400	COG3655	Transcriptional regulator
X953_07405	COG3739	integral membrane protein
X953_07425	COG0406	alpha-ribazole phosphatase activity
X953_07430	COG0842	Transport permease protein
X953_07435	COG1131	(ABC) transporter
X953_07450	COG1619	proteins homologs of microcin C7 resistance protein MccF
X953_07480	COG3588	fructose-bisphosphate aldolase
X953_07500	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
X953_07510	COG0179	Fumarylacetoacetate (FAA) hydrolase
X953_07520	COG4443	Transcriptional Coactivator p15 (PC4)
X953_07565	COG1098	S1 RNA binding domain
X953_07570	COG2112	serine threonine protein kinase
X953_07575	COG1012	belongs to the aldehyde dehydrogenase family
X953_07585	COG1012	belongs to the aldehyde dehydrogenase family
X953_07595	COG3844	kynureninase activity
X953_07600	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
X953_07610	COG0733	neurotransmitter:sodium symporter activity
X953_07615	COG0745	RESPONSE REGULATOR receiver
X953_07630	COG0501	Belongs to the peptidase M48B family
X953_07655	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
X953_07660	COG0456	acetyltransferase
X953_07660	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
X953_07680	COG0667	Aldo Keto reductase
X953_07685	COG3328	transposase activity
X953_07695	COG2322	membrane
X953_07700	COG2226	methyltransferase
X953_07740	COG1366	Belongs to the anti-sigma-factor antagonist family
X953_07750	COG1309	transcriptional regulator
X953_07755	COG2814	Major facilitator Superfamily
X953_07765	COG2217	Heavy metal translocating P-type atpase
X953_07780	COG1196	nuclear chromosome segregation
X953_07780	COG0739	heme binding
X953_07780	COG0741	lytic transglycosylase activity
X953_07785	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
X953_07790	COG2059	Chromate
X953_07795	COG2059	Chromate
X953_07805	COG1309	transcriptional regulator
X953_07840	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
X953_07860	COG1063	alcohol dehydrogenase
X953_07910	COG1368	sulfuric ester hydrolase activity
X953_07915	COG0640	Transcriptional regulator
X953_07920	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
X953_07925	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
X953_07930	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
X953_07940	COG0598	Magnesium transport protein CorA
X953_07950	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
X953_07950	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
X953_07955	COG0307	riboflavin synthase, alpha
X953_07960	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
X953_07960	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
X953_07965	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
X953_07980	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
X953_07985	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
X953_08015	COG5002	protein histidine kinase activity
X953_08020	COG0745	RESPONSE REGULATOR receiver
X953_08030	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
X953_08040	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
X953_08050	COG1533	DNA photolyase activity
X953_08135	COG3311	Transcriptional regulator
X953_08140	COG0659	secondary active sulfate transmembrane transporter activity
X953_08150	COG4990	cell redox homeostasis
X953_08165	COG2329	Antibiotic biosynthesis monooxygenase
X953_08180	COG1366	Belongs to the anti-sigma-factor antagonist family
X953_08180	COG2202	Pas domain
X953_08200	COG2314	TM2 domain
X953_08205	COG1615	UPF0182 protein
X953_08225	COG5504	Zn-dependent protease
X953_08240	COG0482	sulfurtransferase activity
X953_08245	COG3104	oligopeptide transport
X953_08275	COG4294	response to UV
X953_08280	COG0517	IMP dehydrogenase activity
X953_08315	COG2081	HI0933 family
X953_08325	COG1187	pseudouridine synthase activity
X953_08340	COG0510	thiamine kinase activity
X953_08350	COG0220	tRNA (guanine-N7-)-methyltransferase activity
X953_08355	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
X953_08365	COG1363	Peptidase, m42
X953_08370	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
X953_08385	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
X953_08390	COG4848	Belongs to the UPF0354 family
X953_08395	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
X953_08400	COG1674	ftsk spoiiie
X953_08410	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
X953_08420	COG4980	gas vesicle protein
X953_08425	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
X953_08425	COG1605	Chorismate mutase
X953_08445	COG0123	including yeast histone deacetylase and acetoin utilization protein
X953_08450	COG0517	IMP dehydrogenase activity
X953_08455	COG0454	-acetyltransferase
X953_08460	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
X953_08465	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
X953_08470	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
X953_08475	COG2203	Gaf domain
X953_08475	COG2199	diguanylate cyclase activity
X953_08480	COG1956	GAF domain-containing protein
X953_08485	COG1309	transcriptional regulator
X953_08490	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
X953_08495	COG1104	cysteine desulfurase activity
X953_08500	COG0301	tRNA thio-modification
X953_08510	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
X953_08520	COG3874	Sporulation protein YtfJ
X953_08525	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
X953_08535	COG0827	DNA restriction-modification system
X953_08540	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
X953_08545	COG0521	Mo-molybdopterin cofactor biosynthetic process
X953_08550	COG0589	response to stress
X953_08565	COG1842	Phage shock protein A
X953_08580	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
X953_08585	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
X953_08605	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
X953_08615	COG1459	type II secretion system
X953_08625	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
X953_08650	COG4109	DRTGG domain
X953_08660	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
X953_08680	COG0587	DNA-directed DNA polymerase activity
X953_08685	COG0281	malic enzyme
X953_08690	COG2186	Transcriptional regulator
X953_08695	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
X953_08700	COG0825	malonyl-CoA metabolic process
X953_08705	COG0205	6-phosphofructokinase activity
X953_08715	COG3030	protein affecting phage T7 exclusion by the F plasmid
X953_08720	COG0628	permease
X953_08725	COG0372	Belongs to the citrate synthase family
X953_08730	COG0538	isocitrate dehydrogenase activity
X953_08735	COG0039	L-malate dehydrogenase activity
X953_08745	COG0745	RESPONSE REGULATOR receiver
X953_08750	COG5002	protein histidine kinase activity
X953_08755	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
X953_08755	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
X953_08765	COG0237	dephospho-CoA kinase activity
X953_08770	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
X953_08775	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
X953_08785	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
X953_08790	COG3611	Membrane attachment protein
X953_08795	COG1484	DNA-dependent DNA replication
X953_08805	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
X953_08810	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
X953_08815	COG0291	Belongs to the bacterial ribosomal protein bL35 family
X953_08820	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
X953_08830	COG0398	Pfam SNARE associated Golgi protein
X953_08845	COG1363	Peptidase, m42
X953_08850	COG0741	lytic transglycosylase activity
X953_08855	COG1131	(ABC) transporter
X953_08880	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
X953_08890	COG0072	phenylalanine-tRNA ligase activity
X953_08890	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
X953_08895	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
X953_08900	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
X953_08905	COG1286	toxin biosynthetic process
X953_08910	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
X953_08910	COG1796	DNA polymerase
X953_08915	COG1193	negative regulation of DNA recombination
X953_08920	COG3766	membrane
X953_08930	COG0318	PFAM AMP-dependent synthetase and ligase
X953_08935	COG1309	transcriptional regulator
X953_08940	COG1024	Enoyl-CoA hydratase
X953_08945	COG2086	electron transfer activity
X953_08950	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
X953_08955	COG3118	belongs to the thioredoxin family
X953_08960	COG0322	excinuclease ABC activity
X953_08965	COG1719	4-vinyl reductase, 4VR
X953_08970	COG2009	succinate dehydrogenase
X953_08975	COG1053	succinate dehydrogenase
X953_08980	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
X953_08985	COG0824	Thioesterase
X953_08990	COG2197	response regulator
X953_08995	COG1846	Transcriptional regulator
X953_09000	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
X953_09005	COG5401	PFAM Sporulation and spore germination
X953_09010	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
X953_09015	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
X953_09020	COG0622	Phosphoesterase
X953_09035	COG1477	protein flavinylation
X953_09035	COG0457	Tetratricopeptide repeat
X953_09040	COG0544	peptidyl-prolyl cis-trans isomerase activity
X953_09045	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
X953_09055	COG0218	Necessary for normal cell division and for the maintenance of normal septation
X953_09080	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
X953_09085	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
X953_09090	COG0181	hydroxymethylbilane synthase activity
X953_09100	COG0113	porphobilinogen synthase activity
X953_09105	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
X953_09110	COG1388	LysM domain
X953_09110	COG1388	LysM domain
X953_09125	COG0525	valine-tRNA ligase activity
X953_09140	COG0285	dihydrofolate synthase activity
X953_09150	COG2003	Belongs to the UPF0758 family
X953_09160	COG1077	Cell shape determining protein MreB Mrl
X953_09165	COG1792	Involved in formation and maintenance of cell shape
X953_09175	COG0850	regulation of cytokinetic process
X953_09180	COG2894	cell division
X953_09190	COG1994	Peptidase M50
X953_09195	COG0261	This protein binds to 23S rRNA in the presence of protein L20
X953_09200	COG2868	ribosomal protein
X953_09215	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
X953_09220	COG0077	Prephenate dehydratase
X953_09225	COG1388	LysM domain
X953_09235	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
X953_09245	COG0217	transcriptional regulatory protein
X953_09250	COG0632	four-way junction helicase activity
X953_09255	COG2255	four-way junction helicase activity
X953_09265	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
X953_09270	COG0343	queuine tRNA-ribosyltransferase activity
X953_09275	COG1862	Preprotein translocase
X953_09285	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
X953_09290	COG2244	polysaccharide biosynthetic process
X953_09300	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
X953_09300	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
X953_09305	COG5416	Lipopolysaccharide assembly protein A domain
X953_09310	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
X953_09310	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
X953_09315	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
X953_09320	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
X953_09325	COG1490	D-aminoacyl-tRNA deacylase activity
X953_09330	COG0860	N-Acetylmuramoyl-L-alanine amidase
X953_09330	COG3103	Sh3 type 3 domain protein
X953_09330	COG4991	sh3 domain protein
X953_09340	COG0124	histidyl-tRNA synthetase
X953_09345	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
X953_09355	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
X953_09360	COG1959	2 iron, 2 sulfur cluster binding
X953_09365	COG1104	cysteine desulfurase activity
X953_09370	COG0482	sulfurtransferase activity
X953_09380	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
X953_09395	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
X953_09400	COG4472	Bacterial protein of unknown function (DUF965)
X953_09405	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
X953_09410	COG3906	Belongs to the UPF0473 family
X953_09420	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
X953_09430	COG0572	uridine kinase
X953_09435	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
X953_09445	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
X953_09455	COG1191	sigma factor activity
X953_09465	COG2212	antiporter activity
X953_09475	COG0651	ATP synthesis coupled electron transport
X953_09485	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
X953_09485	COG2111	Na H antiporter
X953_09495	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
X953_09500	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
X953_09505	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
X953_09510	COG1534	Rna-binding protein
X953_09515	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
X953_09520	COG1713	HD superfamily hydrolase involved in NAD metabolism
X953_09525	COG0799	negative regulation of ribosome biogenesis
X953_09530	COG2226	methyltransferase
X953_09535	COG1596	polysaccharide export
X953_09535	COG1555	photosystem II stabilization
X953_09540	COG2131	deaminase
X953_09545	COG0658	competence protein
X953_09545	COG2333	competence protein COMEC
X953_09555	COG1466	dna polymerase III delta subunit
X953_09560	COG0268	Binds directly to 16S ribosomal RNA
X953_09565	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
X953_09570	COG0860	N-Acetylmuramoyl-L-alanine amidase
X953_09580	COG0481	GTPase activity
X953_09585	COG0635	Involved in the biosynthesis of porphyrin-containing compound
X953_09590	COG1420	regulation of RNA biosynthetic process
X953_09595	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
X953_09600	COG0443	Heat shock 70 kDa protein
X953_09605	COG0484	heat shock protein binding
X953_09610	COG2264	protein methyltransferase activity
X953_09615	COG1385	rRNA (uridine-N3-)-methyltransferase activity
X953_09620	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
X953_09625	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
X953_09630	COG0828	Belongs to the bacterial ribosomal protein bS21 family
X953_09635	COG1610	YqeY-like protein
X953_09640	COG1030	water channel activity
X953_09645	COG4864	UPF0365 protein
X953_09665	COG1702	phosphate starvation-inducible protein PhoH
X953_09670	COG1480	7TM receptor with intracellular HD hydrolase
X953_09675	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
X953_09685	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
X953_09695	COG1381	Involved in DNA repair and RecF pathway recombination
X953_09705	COG0752	glycyl-tRNA synthetase alpha subunit
X953_09710	COG0751	glycine-tRNA ligase activity
X953_09715	COG0517	IMP dehydrogenase activity
X953_09720	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
X953_09725	COG0358	DNA primase activity
X953_09730	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
X953_09745	COG2384	SAM-dependent methyltransferase
X953_09750	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
X953_09760	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
X953_09770	COG4709	membrane
X953_09820	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
X953_09825	COG0477	Major facilitator Superfamily
X953_09845	COG0267	Belongs to the bacterial ribosomal protein bL33 family
X953_09850	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
X953_09855	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
X953_09860	COG0705	Rhomboid family
X953_09860	COG0457	Tetratricopeptide repeat
X953_09870	COG0697	spore germination
X953_09880	COG1940	carbohydrate kinase activity
X953_09890	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
X953_10055	COG2433	Pfam Transposase IS66
X953_10110	COG0582	viral genome integration into host DNA
X953_10195	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
X953_10200	COG4537	Required for transformation and DNA binding
X953_10210	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
X953_10225	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
X953_10235	COG0404	The glycine cleavage system catalyzes the degradation of glycine
X953_10240	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
X953_10245	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
X953_10250	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
X953_10255	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
X953_10260	COG1321	iron dependent repressor
X953_10265	COG1752	Esterase of the alpha-beta hydrolase superfamily
X953_10280	COG0006	proline dipeptidase activity
X953_10285	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
X953_10290	COG3854	ATPases associated with a variety of cellular activities
X953_10330	COG0511	ligase activity, forming carbon-carbon bonds
X953_10335	COG0439	Biotin carboxylase
X953_10340	COG1302	Protein conserved in bacteria
X953_10345	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
X953_10350	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
X953_10355	COG1570	exodeoxyribonuclease VII activity
X953_10360	COG1722	exodeoxyribonuclease VII activity
X953_10375	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
X953_10380	COG1438	arginine binding
X953_10385	COG0497	DNA recombination
X953_10390	COG0750	zinc metalloprotease
X953_10395	COG0745	RESPONSE REGULATOR receiver
X953_10400	COG0527	aspartate kinase activity
X953_10410	COG3290	protein histidine kinase activity
X953_10410	COG3829	transcription factor binding
X953_10415	COG0280	phosphate acetyltransferase
X953_10430	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
X953_10435	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
X953_10440	COG0022	dehydrogenase e1 component
X953_10445	COG0508	dehydrogenase complex catalyzes the overall conversion of
X953_10455	COG4129	membrane
X953_10470	COG0346	lactoylglutathione lyase activity
X953_10475	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
X953_10480	COG2195	Cleaves the N-terminal amino acid of tripeptides
X953_10485	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
X953_10490	COG1012	belongs to the aldehyde dehydrogenase family
X953_10495	COG1234	tRNA 3'-trailer cleavage
X953_10500	COG1902	pentaerythritol trinitrate reductase activity
X953_10505	COG0584	glycerophosphoryl diester phosphodiesterase
X953_10510	COG4187	Peptidase family M20/M25/M40
X953_10515	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
X953_10520	COG0300	oxidoreductase activity
X953_10530	COG0667	Aldo Keto reductase
X953_10540	COG1379	DNA repair
X953_10545	COG1300	Membrane
X953_10550	COG0735	belongs to the Fur family
X953_10560	COG4974	Belongs to the 'phage' integrase family
X953_10565	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
X953_10585	COG1686	Belongs to the peptidase S11 family
X953_10590	COG1366	Belongs to the anti-sigma-factor antagonist family
X953_10595	COG2172	sigma factor antagonist activity
X953_10615	COG0697	spore germination
X953_10620	COG0019	diaminopimelate decarboxylase activity
X953_10625	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
X953_10630	COG0750	zinc metalloprotease
X953_10645	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
X953_10650	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
X953_10655	COG1686	Belongs to the peptidase S11 family
X953_10660	COG2715	membrane protein required for spore maturation
X953_10665	COG0700	Nucleoside recognition
X953_10670	COG1187	pseudouridine synthase activity
X953_10675	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
X953_10680	COG1333	cytochrome c biogenesis protein
X953_10685	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
X953_10690	COG0745	RESPONSE REGULATOR receiver
X953_10695	COG5002	protein histidine kinase activity
X953_10705	COG1141	Ferredoxin
X953_10710	COG4955	Helix-turn-helix domain
X953_10715	COG0514	ATP-dependent DNA helicase (RecQ)
X953_10720	COG1266	CAAX protease self-immunity
X953_10730	COG1408	metallophosphoesterase
X953_10735	COG4862	establishment of competence for transformation
X953_10740	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
X953_10745	COG0492	ferredoxin-NADP+ reductase activity
X953_10750	COG0252	asparaginase activity
X953_10755	COG2339	peptidase activity
X953_10760	COG3773	Cell wall hydrolase
X953_10760	COG3409	Peptidoglycan-binding domain 1 protein
X953_10765	COG2959	enzyme of heme biosynthesis
X953_10780	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
X953_10790	COG0539	negative regulation of cytoplasmic translation
X953_10810	COG1160	GTP binding
X953_10815	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
X953_10835	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
X953_10840	COG0776	regulation of translation
X953_10850	COG0142	geranyltranstransferase activity
X953_10855	COG2226	methyltransferase
X953_10860	COG0142	geranyltranstransferase activity
X953_10865	COG0105	UTP biosynthetic process
X953_10875	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
X953_10880	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
X953_10885	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
X953_10890	COG4401	Chorismate mutase type I
X953_10895	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
X953_10900	COG0287	Prephenate dehydrogenase
X953_10905	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
X953_10915	COG5582	Belongs to the UPF0302 family
X953_10925	COG0723	plastoquinol--plastocyanin reductase activity
X953_10930	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
X953_10940	COG4347	Protein of unknown function (DUF1405)
X953_10950	COG2738	Putative neutral zinc metallopeptidase
X953_10955	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
X953_10960	COG1694	Mazg nucleotide pyrophosphohydrolase
X953_10965	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
X953_10970	COG1803	Methylglyoxal synthase
X953_10975	COG0438	transferase activity, transferring glycosyl groups
X953_10980	COG0617	tRNA 3'-terminal CCA addition
X953_10995	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
X953_11000	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
X953_11005	COG1199	ATP-dependent helicase activity
X953_11005	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
X953_11020	COG0436	Aminotransferase
X953_11025	COG0017	Asparaginyl-tRNA synthetase
X953_11030	COG3935	DnaD domain protein
X953_11035	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
X953_11040	COG4499	WXG100 protein secretion system (Wss), protein YukC
X953_11040	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
X953_11045	COG3331	DNA recombination
X953_11070	COG0295	cytidine deaminase activity
X953_11075	COG3599	regulation of cell shape
X953_11085	COG0116	Belongs to the methyltransferase superfamily
X953_11090	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
X953_11095	COG3424	synthase
X953_11100	COG1755	Isoprenylcysteine carboxyl methyltransferase
X953_11110	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
X953_11115	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
X953_11130	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
X953_11135	COG1278	Cold shock
X953_11145	COG1418	mRNA catabolic process
X953_11150	COG0791	NLP P60 protein
X953_11150	COG1388	LysM domain
X953_11155	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
X953_11160	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
X953_11170	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
X953_11175	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
X953_11180	COG0805	protein transport
X953_11185	COG4479	Belongs to the UPF0346 family
X953_11200	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
X953_11200	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
X953_11220	COG1254	Belongs to the acylphosphatase family
X953_11240	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
X953_11245	COG1140	nitrate reductase beta subunit
X953_11255	COG2181	nitrate reductase activity
X953_11260	COG0723	plastoquinol--plastocyanin reductase activity
X953_11260	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
X953_11265	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
X953_11275	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
X953_11275	COG0723	plastoquinol--plastocyanin reductase activity
X953_11280	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
X953_11285	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
X953_11290	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
X953_11295	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
X953_11300	COG1024	Enoyl-CoA hydratase
X953_11305	COG0511	ligase activity, forming carbon-carbon bonds
X953_11310	COG0439	Biotin carboxylase
X953_11315	COG0318	PFAM AMP-dependent synthetase and ligase
X953_11320	COG1960	acyl-CoA dehydrogenase activity
X953_11325	COG1309	transcriptional regulator
X953_11330	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
X953_11335	COG0187	DNA topoisomerase II activity
X953_11340	COG1832	CoA-binding protein
X953_11345	COG1174	glycine betaine transport
X953_11355	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
X953_11360	COG1469	GTP cyclohydrolase I activity
X953_11365	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
X953_11375	COG0824	Thioesterase
X953_11385	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
X953_11395	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
X953_11400	COG4191	Histidine kinase
X953_11410	COG4846	Membrane protein involved in cytochrome C biogenesis
X953_11415	COG2201	protein-glutamate methylesterase activity
X953_11420	COG2111	Na H antiporter
X953_11425	COG0785	Cytochrome C biogenesis protein
X953_11430	COG3763	UPF0154 protein
X953_11445	COG4224	UPF0291 protein
X953_11450	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
X953_11460	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
X953_11465	COG0174	glutamine synthetase
X953_11470	COG0789	Transcriptional regulator
X953_11475	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
X953_11480	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
X953_11485	COG0464	growth
X953_11495	COG1923	regulation of RNA biosynthetic process
X953_11500	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
X953_11505	COG0783	Belongs to the Dps family
X953_11510	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
X953_11515	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
X953_11525	COG4550	Control of competence regulator ComK, YlbF/YmcA
X953_11530	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
X953_11535	COG2359	stage V sporulation protein S
X953_11540	COG1692	metallophosphoesterase
X953_11545	COG1418	mRNA catabolic process
X953_11550	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
X953_11555	COG1058	Belongs to the CinA family
X953_11555	COG1546	Belongs to the CinA family
X953_11560	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
X953_11565	COG1426	Protein conserved in bacteria
X953_11580	COG0300	oxidoreductase activity
X953_11585	COG0612	Peptidase, M16
X953_11590	COG0612	Peptidase, M16
X953_11615	COG2188	Transcriptional regulator
X953_11620	COG1674	ftsk spoiiie
X953_11630	COG0740	serine-type endopeptidase activity
X953_11635	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
X953_11640	COG0527	aspartate kinase activity
X953_11645	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
X953_11650	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
X953_11655	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
X953_11660	COG1873	PFAM PRC-barrel domain
X953_11675	COG0612	Peptidase, M16
X953_11680	COG0726	polysaccharide deacetylase
X953_11695	COG1185	polyribonucleotide nucleotidyltransferase activity
X953_11700	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
X953_11705	COG0196	riboflavin kinase activity
X953_11710	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
X953_11715	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
X953_11725	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
X953_11730	COG1358	cellular component organization or biogenesis
X953_11735	COG2740	Nucleic-acid-binding protein implicated in transcription termination
X953_11740	COG0195	Participates in both transcription termination and antitermination
X953_11745	COG0779	Required for maturation of 30S ribosomal subunits
X953_11750	COG1366	Belongs to the anti-sigma-factor antagonist family
X953_11755	COG2176	DNA-directed DNA polymerase activity
X953_11760	COG0750	zinc metalloprotease
X953_11765	COG4589	Belongs to the CDS family
X953_11770	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
X953_11780	COG0233	cytoplasmic translational termination
X953_11785	COG0528	UMP kinase activity
X953_11790	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
X953_11795	COG0052	Belongs to the universal ribosomal protein uS2 family
X953_11820	COG1191	sigma factor activity
X953_11825	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
X953_11830	COG1776	CheC inhibitor of MCP methylation
X953_11835	COG0835	chemotaxis
X953_11840	COG2201	protein-glutamate methylesterase activity
X953_11845	COG0455	bacterial-type flagellum organization
X953_11850	COG1419	protein localization to endoplasmic reticulum
X953_11855	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
X953_11860	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
X953_11865	COG1684	flagellar biosynthetic protein fliR
X953_11870	COG1987	bacterial-type flagellum assembly
X953_11875	COG1338	Plays a role in the flagellum-specific transport system
X953_11880	COG3190	flagellar
X953_11885	COG2201	protein-glutamate methylesterase activity
X953_11890	COG1776	CheC inhibitor of MCP methylation
X953_11890	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
X953_11895	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
X953_11900	COG1580	Controls the rotational direction of flagella during chemotaxis
X953_11905	COG1582	Flagellar protein (FlbD)
X953_11910	COG4786	Flagellar basal body rod
X953_11920	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
X953_11940	COG1157	protein secretion by the type III secretion system
X953_11950	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
X953_11955	COG1766	The M ring may be actively involved in energy transduction
X953_11960	COG1677	Flagellar hook-basal body complex protein FliE
X953_11965	COG1558	bacterial-type flagellum-dependent cell motility
X953_11970	COG1815	bacterial-type flagellum-dependent cell motility
X953_11975	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
X953_11980	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
X953_11985	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
X953_11990	COG4974	Belongs to the 'phage' integrase family
X953_12000	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
X953_12005	COG0758	DNA mediated transformation
X953_12010	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
X953_12015	COG0045	succinate-CoA ligase (ADP-forming) activity
X953_12020	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
X953_12030	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
X953_12035	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
X953_12045	COG0335	large ribosomal subunit rRNA binding
X953_12050	COG0336	Belongs to the RNA methyltransferase TrmD family
X953_12055	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
X953_12065	COG1837	Belongs to the UPF0109 family
X953_12070	COG0228	four-way junction DNA binding
X953_12075	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
X953_12080	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
X953_12085	COG0552	protein localization to endoplasmic reticulum
X953_12090	COG1196	nuclear chromosome segregation
X953_12095	COG4840	Belongs to the UPF0435 family
X953_12100	COG0571	ribonuclease III activity
X953_12105	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
X953_12110	COG1028	Short-chain dehydrogenase reductase Sdr
X953_12115	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
X953_12120	COG0416	fatty acid biosynthetic process
X953_12125	COG1349	DNA-binding transcription factor activity
X953_12130	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
X953_12135	COG1760	l-serine dehydratase
X953_12140	COG1760	l-serine dehydratase
X953_12150	COG1461	Dihydroxyacetone kinase
X953_12155	COG1302	Protein conserved in bacteria
X953_12160	COG0227	Belongs to the bacterial ribosomal protein bL28 family
X953_12170	COG1564	THIamine pyrophosphokinase
X953_12175	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
X953_12180	COG1162	GTPase activity
X953_12185	COG0515	serine threonine protein kinase
X953_12185	COG2815	serine threonine protein kinase
X953_12190	COG0631	protein serine/threonine phosphatase activity
X953_12195	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
X953_12195	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
X953_12200	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
X953_12205	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
X953_12210	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
X953_12215	COG1758	RNA polymerase activity
X953_12220	COG0194	GDP metabolic process
X953_12225	COG2052	Domain of unknown function (DUF370)
X953_12230	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
X953_12240	COG1764	response to oxidative stress
X953_12245	COG0583	DNA-binding transcription factor activity
X953_12250	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
X953_12255	COG0284	orotidine-5'-phosphate decarboxylase activity
X953_12260	COG0167	dihydroorotate dehydrogenase activity
X953_12265	COG0543	2 iron, 2 sulfur cluster binding
X953_12270	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
X953_12275	COG0505	Belongs to the CarA family
X953_12285	COG0540	Belongs to the ATCase OTCase family
X953_12290	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
X953_12295	COG0564	pseudouridine synthase activity
X953_12300	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
X953_12305	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
X953_12310	COG3599	regulation of cell shape
X953_12315	COG2302	S4 RNA-binding domain
X953_12320	COG1799	cell septum assembly
X953_12325	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
X953_12335	COG1873	PFAM PRC-barrel domain
X953_12340	COG1191	sigma factor activity
X953_12345	COG1191	sigma factor activity
X953_12355	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
X953_12360	COG0849	cell division
X953_12365	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
X953_12370	COG0772	Belongs to the SEDS family
X953_12375	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
X953_12380	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
X953_12385	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
X953_12390	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
X953_12395	COG0768	penicillin binding
X953_12405	COG4839	cell division protein FtsL
X953_12410	COG0275	rRNA processing
X953_12415	COG2001	Belongs to the MraZ family
X953_12420	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
X953_12430	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
X953_12435	COG0454	-acetyltransferase
X953_12445	COG1024	Enoyl-CoA hydratase
X953_12450	COG0333	Belongs to the bacterial ribosomal protein bL32 family
X953_12460	COG1323	Belongs to the UPF0348 family
X953_12465	COG3480	Lon protease (S16) C-terminal proteolytic domain
X953_12470	COG3314	Sporulation integral membrane protein YlbJ
X953_12475	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
X953_12480	COG0742	ribosomal rna small subunit methyltransferase
X953_12485	COG4471	UPF0298 protein
X953_12490	COG3679	Belongs to the UPF0342 family
X953_12505	COG2340	Cysteine-rich secretory protein family
X953_12520	COG2322	membrane
X953_12525	COG3336	cytochrome c oxidase
X953_12535	COG1845	cytochrome c oxidase, subunit III
X953_12540	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
X953_12550	COG0109	protoheme IX farnesyltransferase activity
X953_12555	COG1612	heme a metabolic process
X953_12560	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
X953_12565	COG0772	Belongs to the SEDS family
X953_12570	COG4838	Belongs to the UPF0358 family
X953_12575	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
X953_12590	COG4896	Protein conserved in bacteria
X953_12605	COG0483	inositol monophosphate 1-phosphatase activity
X953_12620	COG4476	Belongs to the UPF0223 family
X953_12630	COG1982	Orn Lys Arg decarboxylase major
X953_12665	COG0022	dehydrogenase e1 component
X953_12675	COG0497	DNA recombination
X953_12680	COG0242	peptide deformylase activity
X953_12685	COG0561	phosphatase activity
X953_12695	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
X953_12700	COG0028	Belongs to the TPP enzyme family
X953_12705	COG0569	domain protein
X953_12710	COG1132	(ABC) transporter
X953_12715	COG1132	(ABC) transporter
X953_12720	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
X953_12725	COG0450	alkyl hydroperoxide reductase
X953_12735	COG1473	amidohydrolase
X953_12740	COG2171	N-acyltransferase activity
X953_12745	COG0517	IMP dehydrogenase activity
X953_12750	COG0640	Transcriptional regulator
X953_12765	COG1408	metallophosphoesterase
X953_12785	COG0697	spore germination
X953_12790	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
X953_12800	COG0436	Aminotransferase
X953_12810	COG0681	Belongs to the peptidase S26 family
X953_12820	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
X953_12825	COG3835	regulator
X953_12840	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
X953_12845	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
X953_12855	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
X953_12860	COG0303	'Molybdopterin
X953_12885	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
X953_12900	COG2323	membrane
X953_12905	COG1301	dicarboxylic acid transport
X953_12910	COG0604	alcohol dehydrogenase
X953_12915	COG0003	Pfam Anion-transporting ATPase
X953_12925	COG1966	Carbon starvation protein
X953_12930	COG2427	Protein of unknown function (DUF1641)
X953_12935	COG3383	formate dehydrogenase (NAD+) activity
X953_12945	COG3069	C4-dicarboxylate transmembrane transporter activity
X953_12960	COG3859	Proton-coupled thiamine transporter YuaJ
X953_12965	COG2353	YceI-like domain
X953_12970	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
X953_13000	COG1252	NADH dehydrogenase
X953_13015	COG0318	PFAM AMP-dependent synthetase and ligase
X953_13050	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
X953_13065	COG1725	Transcriptional regulator
X953_13075	COG2027	D-alanyl-D-alanine carboxypeptidase
X953_13085	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
X953_13090	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
X953_13100	COG1917	Cupin 2, conserved barrel domain protein
X953_13105	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
X953_13120	COG1174	glycine betaine transport
X953_13125	COG1732	Glycine betaine
X953_13130	COG1174	glycine betaine transport
X953_13140	COG1510	regulation of RNA biosynthetic process
X953_13150	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
X953_13160	COG0402	S-adenosylhomocysteine deaminase activity
X953_13165	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
X953_13190	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
X953_13200	COG0495	leucyl-tRNA aminoacylation
X953_13205	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
X953_13210	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
X953_13215	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
X953_13220	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
X953_13225	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
X953_13230	COG1116	anion transmembrane transporter activity
X953_13235	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
X953_13240	COG0494	nUDIX hydrolase
X953_13255	COG1120	ATPase activity
X953_13260	COG0318	PFAM AMP-dependent synthetase and ligase
X953_13265	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
X953_13270	COG0596	Alpha beta hydrolase
X953_13275	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
X953_13280	COG1169	isochorismate synthase
X953_13285	COG1575	Belongs to the MenA family. Type 1 subfamily
X953_13290	COG2050	protein possibly involved in aromatic compounds catabolism
X953_13295	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
X953_13300	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
X953_13305	COG1404	Belongs to the peptidase S8 family
X953_13305	COG4412	M6 family metalloprotease domain protein
X953_13320	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
X953_13330	COG1098	S1 RNA binding domain
X953_13335	COG2155	Conserved Protein
X953_13340	COG0166	Belongs to the GPI family
X953_13345	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
X953_13350	COG2032	superoxide dismutase activity
X953_13365	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
X953_13370	COG0813	purine-nucleoside phosphorylase activity
X953_13375	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
X953_13380	COG3584	3D domain protein
X953_13390	COG1252	NADH dehydrogenase
X953_13395	COG0492	ferredoxin-NADP+ reductase activity
X953_13400	COG0316	Belongs to the HesB IscA family
X953_13405	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
X953_13410	COG4837	Protein of unknown function (DUF1462)
X953_13415	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
X953_13420	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
X953_13425	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
X953_13430	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
X953_13435	COG0647	UMP catabolic process
X953_13445	COG2445	Protein of unknown function DUF86
X953_13455	COG0154	amidase activity
X953_13465	COG4470	Protein conserved in bacteria
X953_13475	COG0739	heme binding
X953_13485	COG0733	neurotransmitter:sodium symporter activity
X953_13490	COG1757	Na H antiporter
X953_13500	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
X953_13505	COG3377	Domain of unknown function (DUF1805)
X953_13510	COG0737	Belongs to the 5'-nucleotidase family
X953_13515	COG0730	response to heat
X953_13520	COG0719	Fe-S assembly protein
X953_13525	COG0822	iron-sulfur transferase activity
X953_13530	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
X953_13535	COG0719	Fe-S assembly protein
X953_13540	COG0396	ATPase activity
X953_13550	COG1464	Belongs to the NlpA lipoprotein family
X953_13555	COG2011	ABC-type metal ion transport system permease component
X953_13560	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
X953_13565	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
X953_13570	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
X953_13575	COG0509	glycine decarboxylation via glycine cleavage system
X953_13580	COG1393	Belongs to the ArsC family
X953_13585	COG1960	acyl-CoA dehydrogenase activity
X953_13590	COG0183	Belongs to the thiolase family
X953_13595	COG1250	3-hydroxyacyl-CoA dehydrogenase
X953_13595	COG1024	Enoyl-CoA hydratase
X953_13600	COG0506	proline dehydrogenase activity
X953_13610	COG2217	Heavy metal translocating P-type atpase
X953_13615	COG1937	Protein conserved in bacteria
X953_13625	COG1121	(ABC) transporter
X953_13630	COG1108	ABC-type Mn2 Zn2 transport systems permease components
X953_13640	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
X953_13645	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
X953_13660	COG3883	PFAM NLP P60 protein
X953_13660	COG0791	NLP P60 protein
X953_13665	COG2224	Isocitrate lyase
X953_13670	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
X953_13680	COG4129	membrane
X953_13685	COG2197	response regulator
X953_13690	COG4585	Histidine kinase
X953_13695	COG4758	membrane
X953_13710	COG2814	Major facilitator Superfamily
X953_13715	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
X953_13730	COG1363	Peptidase, m42
X953_13735	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
X953_13740	COG0803	Belongs to the bacterial solute-binding protein 9 family
X953_13745	COG1108	ABC-type Mn2 Zn2 transport systems permease components
X953_13750	COG1121	(ABC) transporter
X953_13760	COG1647	Serine aminopeptidase, S33
X953_13765	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
X953_13790	COG0148	phosphopyruvate hydratase activity
X953_13795	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
X953_13800	COG0149	triose-phosphate isomerase activity
X953_13805	COG0126	phosphoglycerate kinase activity
X953_13825	COG0328	RNA-DNA hybrid ribonuclease activity
X953_13830	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
X953_13835	COG3162	membrane
X953_13840	COG2610	gluconate transmembrane transporter activity
X953_13850	COG1028	Short-chain dehydrogenase reductase Sdr
X953_13855	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
X953_13860	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
X953_13885	COG0710	3-dehydroquinate dehydratase activity
X953_13890	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
X953_13900	COG0740	serine-type endopeptidase activity
X953_13905	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
X953_13910	COG1481	regulation of sporulation
X953_13915	COG0391	Required for morphogenesis under gluconeogenic growth conditions
X953_13920	COG1660	Displays ATPase and GTPase activities
X953_13925	COG1051	belongs to the nudix hydrolase family
X953_13930	COG0492	ferredoxin-NADP+ reductase activity
X953_13935	COG0457	Tetratricopeptide repeat
X953_13940	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
X953_13945	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
X953_13950	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
X953_13960	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
X953_13965	COG0110	maltose O-acetyltransferase activity
X953_13970	COG0546	phosphoglycolate phosphatase activity
X953_13975	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
X953_13980	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
X953_13985	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
X953_13990	COG1950	PFAM Membrane protein of
X953_13995	COG1983	PspC domain protein
X953_14005	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
X953_14010	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
X953_14015	COG0556	nucleotide-excision repair
X953_14025	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
X953_14030	COG3409	Peptidoglycan-binding domain 1 protein
X953_14030	COG0793	Belongs to the peptidase S41A family
X953_14035	COG0739	heme binding
X953_14040	COG2177	Part of the ABC transporter FtsEX involved in
X953_14045	COG2884	Cell division ATP-binding protein ftsE
X953_14055	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
X953_14060	COG0653	protein targeting
X953_14070	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
X953_14080	COG1516	flagellar protein fliS
X953_14085	COG1334	flagellar protein FlaG
X953_14090	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
X953_14095	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
X953_14105	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
X953_14110	COG4786	Flagellar basal body rod
X953_14110	COG1256	bacterial-type flagellum assembly
X953_14130	COG1040	competence protein
X953_14135	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
X953_14140	COG1307	EDD domain protein, DegV family
X953_14145	COG2197	response regulator
X953_14150	COG4585	Histidine kinase
X953_14155	COG1739	Uncharacterized protein family UPF0029
X953_14160	COG0363	glucosamine-6-phosphate deaminase activity
X953_14165	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
X953_14170	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
X953_14170	COG2190	(PTS) system
X953_14170	COG1263	PTS System
X953_14200	COG0681	Belongs to the peptidase S26 family
X953_14220	COG3764	Sortase (surface protein transpeptidase)
X953_14225	COG1316	TRANSCRIPTIONal
X953_14230	COG0768	penicillin binding
X953_14250	COG1012	belongs to the aldehyde dehydrogenase family
X953_14260	COG0561	phosphatase activity
X953_14265	COG2814	Major facilitator Superfamily
X953_14270	COG1984	allophanate hydrolase subunit 2
X953_14275	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
X953_14280	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
X953_14285	COG0471	metal ion transport
X953_14290	COG2814	Major facilitator Superfamily
X953_14295	COG2807	transmembrane transport
X953_14305	COG1368	sulfuric ester hydrolase activity
X953_14310	COG0840	transmembrane signaling receptor activity
X953_14315	COG2197	response regulator
X953_14320	COG0840	transmembrane signaling receptor activity
X953_14325	COG2200	EAL domain
X953_14330	COG2201	protein-glutamate methylesterase activity
X953_14335	COG0835	chemotaxis
X953_14340	COG0643	Histidine kinase
X953_14340	COG2198	Histidine kinase
X953_14350	COG1360	Flagellar Motor Protein
X953_14355	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
X953_14360	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
X953_14380	COG0840	transmembrane signaling receptor activity
X953_14390	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
X953_14400	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
X953_14405	COG1472	Belongs to the glycosyl hydrolase 3 family
X953_14410	COG3876	Protein conserved in bacteria
X953_14415	COG0395	ABC-type sugar transport system, permease component
X953_14430	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
X953_14435	COG1737	Transcriptional regulator
X953_14440	COG2971	BadF BadG BcrA BcrD
X953_14445	COG0716	FMN binding
X953_14460	COG1331	Highly conserved protein containing a thioredoxin domain
X953_14495	COG1971	Probably functions as a manganese efflux pump
X953_14510	COG2996	Protein conserved in bacteria
X953_14520	COG4895	conserved protein (DUF2196)
X953_14535	COG0561	phosphatase activity
X953_14555	COG4565	transcriptional regulatory protein
X953_14560	COG3290	protein histidine kinase activity
X953_14570	COG2271	Major facilitator Superfamily
X953_14575	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
X953_14590	COG1929	Belongs to the glycerate kinase type-1 family
X953_14595	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
X953_14605	COG0747	negative chemotaxis
X953_14615	COG0601	transmembrane transport
X953_14620	COG4608	Belongs to the ABC transporter superfamily
X953_14630	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
X953_14640	COG0463	Glycosyl transferase, family 2
X953_14650	COG2076	Multidrug Resistance protein
X953_14655	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
X953_14665	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
X953_14675	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
X953_14690	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
X953_14695	COG0473	3-isopropylmalate dehydrogenase activity
X953_14700	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
X953_14705	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
X953_14710	COG0440	acetolactate synthase activity
X953_14715	COG0028	Belongs to the TPP enzyme family
X953_14720	COG0129	dihydroxy-acid dehydratase activity
X953_14725	COG0385	Bile acid
X953_14730	COG1574	metal-dependent hydrolase with the TIM-barrel fold
X953_14745	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
X953_14755	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
X953_14765	COG0251	oxidation-reduction process
X953_14770	COG1012	belongs to the aldehyde dehydrogenase family
X953_14775	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
X953_14780	COG1802	Transcriptional regulator
X953_14785	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
X953_14790	COG0006	proline dipeptidase activity
X953_14800	COG0656	L-ascorbic acid biosynthetic process
X953_14850	COG0805	protein transport
X953_14855	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
X953_14865	COG0860	N-Acetylmuramoyl-L-alanine amidase
X953_14875	COG0583	DNA-binding transcription factor activity
X953_14880	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
X953_14885	COG0686	Belongs to the AlaDH PNT family
X953_14895	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
X953_14905	COG0765	amino acid transport
X953_14910	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
X953_14915	COG1012	belongs to the aldehyde dehydrogenase family
X953_14920	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
X953_14925	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
X953_14935	COG3258	Cytochrome c
X953_14945	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
X953_14975	COG0419	ATPase involved in DNA repair
X953_14980	COG0420	3'-5' exonuclease activity
X953_15005	COG1846	Transcriptional regulator
X953_15010	COG2814	Major facilitator Superfamily
X953_15025	COG0390	transport system, permease component
X953_15040	COG2706	6-phosphogluconolactonase activity
X953_15060	COG1105	Belongs to the carbohydrate kinase PfkB family
X953_15065	COG3684	Belongs to the aldolase LacD family
X953_15075	COG2222	sugar isomerase
X953_15095	COG3119	arylsulfatase activity
X953_15105	COG1609	Transcriptional regulator
X953_15115	COG1316	TRANSCRIPTIONal
X953_15120	COG4166	transmembrane transport
X953_15125	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
X953_15130	COG2233	PERMEase
X953_15140	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
X953_15175	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
X953_15180	COG2223	nitrite transmembrane transporter activity
X953_15195	COG3764	Sortase (surface protein transpeptidase)
X953_15205	COG1268	BioY protein
X953_15215	COG3383	formate dehydrogenase (NAD+) activity
X953_15220	COG5609	conserved protein (DUF2294)
X953_15225	COG3223	Belongs to the PsiE family
X953_15230	COG0431	NADPH-dependent FMN reductase
X953_15245	COG1012	belongs to the aldehyde dehydrogenase family
X953_15265	COG3541	Predicted nucleotidyltransferase
X953_15275	COG0706	membrane insertase activity
X953_15280	COG1404	Belongs to the peptidase S8 family
X953_15285	COG2814	Major facilitator Superfamily
X953_15295	COG4948	Mandelate Racemase Muconate Lactonizing
X953_15300	COG1404	Belongs to the peptidase S8 family
X953_15305	COG2027	D-alanyl-D-alanine carboxypeptidase
X953_15315	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
X953_15325	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
X953_15330	COG1556	Lactate utilization protein
X953_15335	COG1139	Iron-sulfur cluster binding protein
X953_15340	COG0247	lactate metabolic process
X953_15345	COG2186	Transcriptional regulator
X953_15350	COG1620	l-lactate permease
X953_15365	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
X953_15370	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
X953_15385	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
X953_15440	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
X953_15450	COG1028	Short-chain dehydrogenase reductase Sdr
X953_15455	COG1215	transferase activity, transferring glycosyl groups
X953_15475	COG2197	response regulator
X953_15490	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
X953_15505	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
X953_15510	COG0251	oxidation-reduction process
X953_15520	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
X953_15535	COG2368	4-hydroxyphenylacetate
X953_15540	COG1132	(ABC) transporter
X953_15550	COG1012	belongs to the aldehyde dehydrogenase family
X953_15555	COG0840	transmembrane signaling receptor activity
X953_15565	COG1609	Transcriptional regulator
X953_15580	COG2233	PERMEase
X953_15585	COG0402	S-adenosylhomocysteine deaminase activity
X953_15595	COG3775	system Galactitol-specific IIC component
X953_15600	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
X953_15605	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
X953_15610	COG2022	thiamine diphosphate biosynthetic process
X953_15620	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
X953_15625	COG0352	thiamine-phosphate diphosphorylase activity
X953_15655	COG1737	Transcriptional regulator
X953_15660	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
X953_15665	COG3876	Protein conserved in bacteria
X953_15670	COG1472	Belongs to the glycosyl hydrolase 3 family
X953_15675	COG0395	ABC-type sugar transport system, permease component
X953_15680	COG1175	transmembrane transport
X953_15690	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
X953_15695	COG1082	Xylose isomerase domain protein TIM barrel
X953_15700	COG0673	inositol 2-dehydrogenase activity
X953_15705	COG0673	inositol 2-dehydrogenase activity
X953_15715	COG0673	inositol 2-dehydrogenase activity
X953_15730	COG1653	transport
X953_15735	COG1028	Short-chain dehydrogenase reductase Sdr
X953_15740	COG1609	Transcriptional regulator
X953_15750	COG1454	alcohol dehydrogenase
X953_15760	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
X953_15780	COG2514	catechol 2,3-dioxygenase activity
X953_15785	COG1733	regulation of RNA biosynthetic process
X953_15795	COG1262	PFAM Formylglycine-generating sulfatase enzyme
X953_15800	COG0583	DNA-binding transcription factor activity
X953_15805	COG0730	response to heat
X953_15810	COG0402	S-adenosylhomocysteine deaminase activity
X953_15845	COG1846	Transcriptional regulator
X953_15850	COG2409	Drug exporters of the RND superfamily
X953_15850	COG1033	growth of symbiont in host cell
X953_15860	COG4166	transmembrane transport
X953_15895	COG2936	dipeptidyl-peptidase activity
X953_15905	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
X953_15910	COG0601	transmembrane transport
X953_15920	COG4608	Belongs to the ABC transporter superfamily
X953_15925	COG0444	Belongs to the ABC transporter superfamily
X953_15930	COG1012	belongs to the aldehyde dehydrogenase family
X953_15935	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
X953_15940	COG1757	Na H antiporter
X953_15950	COG3938	Belongs to the proline racemase family
X953_15955	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
X953_15985	COG2362	D-Aminopeptidase
X953_15995	COG4608	Belongs to the ABC transporter superfamily
X953_16000	COG0444	Belongs to the ABC transporter superfamily
X953_16005	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
X953_16010	COG0601	transmembrane transport
X953_16015	COG0747	negative chemotaxis
X953_16025	COG0366	Alpha amylase catalytic
X953_16035	COG1609	Transcriptional regulator
X953_16065	COG1011	Hydrolase
X953_16070	COG2936	dipeptidyl-peptidase activity
X953_16080	COG0174	glutamine synthetase
X953_16085	COG0493	'glutamate synthase
X953_16090	COG0070	glutamate synthase
X953_16090	COG0069	glutamate synthase activity
X953_16090	COG0067	glutamate synthase
X953_16095	COG0583	DNA-binding transcription factor activity
X953_16100	COG0367	asparagine synthase
X953_16105	COG0446	pyridine nucleotide-disulphide oxidoreductase
X953_16120	COG5444	nuclease activity
X953_16130	COG5444	nuclease activity
X953_16155	COG5298	Protein conserved in bacteria
X953_16160	COG1215	transferase activity, transferring glycosyl groups
X953_16175	COG1192	Involved in chromosome partitioning
X953_16200	COG3949	Membrane
X953_16205	COG4948	Mandelate Racemase Muconate Lactonizing
X953_16215	COG1473	amidohydrolase
X953_16225	COG1476	TRANSCRIPTIONal
X953_16235	COG2972	Histidine kinase
X953_16235	COG0745	RESPONSE REGULATOR receiver
X953_16375	COG4166	transmembrane transport
X953_16380	COG1737	Transcriptional regulator
X953_16385	COG1473	amidohydrolase
X953_16390	COG3716	PTS system mannose fructose sorbose family IID component
X953_16395	COG3715	PTS system
X953_16400	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
X953_16400	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
X953_16435	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
X953_16450	COG1396	sequence-specific DNA binding
X953_16495	COG0606	chelatase, subunit chli
X953_16555	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
X953_16560	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
X953_16565	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
X953_16565	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
X953_16570	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
X953_16575	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
X953_16590	COG1210	Utp--glucose-1-phosphate uridylyltransferase
X953_16610	COG4464	protein tyrosine phosphatase activity
X953_16615	COG0489	protein tyrosine kinase activity
X953_16620	COG3944	biosynthesis protein
X953_16625	COG1388	LysM domain
X953_16625	COG0791	NLP P60 protein
X953_16660	COG0165	Argininosuccinate lyase
X953_16670	COG3842	ATPase activity
X953_16675	COG1840	ABC-type Fe3 transport system, periplasmic component
X953_16695	COG1940	carbohydrate kinase activity
X953_16715	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
X953_16720	COG1482	cell wall glycoprotein biosynthetic process
X953_16725	COG1940	carbohydrate kinase activity
X953_16740	COG1175	transmembrane transport
X953_16750	COG2207	Transcriptional regulator
X953_16750	COG4753	response regulator
X953_16755	COG2972	Histidine kinase
X953_16760	COG1879	ABC-type sugar transport system periplasmic component
X953_16790	COG2207	Transcriptional regulator
X953_16790	COG4753	response regulator
X953_16795	COG2972	Histidine kinase
X953_16810	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
X953_16825	COG3142	Participates in the control of copper homeostasis
X953_16840	COG3711	transcriptional antiterminator
X953_16850	COG0432	Pfam Uncharacterised protein family UPF0047
X953_16855	COG0745	RESPONSE REGULATOR receiver
X953_16855	COG2972	Histidine kinase
X953_16865	COG3279	Response regulator of the LytR AlgR family
X953_16900	COG1316	TRANSCRIPTIONal
X953_16905	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
X953_16910	COG0438	transferase activity, transferring glycosyl groups
X953_16920	COG1216	Glycosyl transferase, family 2
X953_16940	COG0584	glycerophosphoryl diester phosphodiesterase
X953_16950	COG1682	transport, permease protein
X953_16960	COG4193	domain, Protein
X953_16990	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
X953_16995	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
X953_17005	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
X953_17010	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
X953_17015	COG1368	sulfuric ester hydrolase activity
X953_17030	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
X953_17035	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
X953_17045	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
X953_17055	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
X953_17080	COG2076	Multidrug Resistance protein
X953_17085	COG2076	Multidrug Resistance protein
X953_17105	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
X953_17115	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
X953_17125	COG1309	transcriptional regulator
X953_17135	COG4980	gas vesicle protein
X953_17145	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
X953_17160	COG4786	Flagellar basal body rod
X953_17165	COG4786	Flagellar basal body rod
X953_17170	COG1077	Cell shape determining protein MreB Mrl
X953_17175	COG1609	Transcriptional regulator
X953_17190	COG0739	heme binding
X953_17200	COG2385	sporulation resulting in formation of a cellular spore
X953_17205	COG4608	Belongs to the ABC transporter superfamily
X953_17210	COG0791	NLP P60 protein
X953_17215	COG4948	Mandelate Racemase Muconate Lactonizing
X953_17220	COG1619	proteins homologs of microcin C7 resistance protein MccF
X953_17225	COG4166	transmembrane transport
X953_17230	COG0444	Belongs to the ABC transporter superfamily
X953_17235	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
X953_17240	COG0601	transmembrane transport
X953_17245	COG2362	D-Aminopeptidase
X953_17250	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
X953_17270	COG0355	proton-transporting ATP synthase activity, rotational mechanism
X953_17275	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
X953_17280	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
X953_17285	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
X953_17290	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
X953_17295	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
X953_17300	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
X953_17305	COG0356	it plays a direct role in the translocation of protons across the membrane
X953_17315	COG1404	Belongs to the peptidase S8 family
X953_17320	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
X953_17325	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
X953_17330	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
X953_17335	COG4475	Protein of unknown function (DUF436)
X953_17340	COG0698	ribose 5-phosphate isomerase
X953_17345	COG0840	transmembrane signaling receptor activity
X953_17350	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
X953_17355	COG1971	Probably functions as a manganese efflux pump
X953_17360	COG0009	L-threonylcarbamoyladenylate synthase
X953_17380	COG2890	protein-(glutamine-N5) methyltransferase activity
X953_17385	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
X953_17390	COG1435	thymidine kinase activity
X953_17395	COG0254	rRNA binding
X953_17400	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
X953_17405	COG1494	fructose-1,6-bisphosphatase
X953_17410	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
X953_17415	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
X953_17420	COG0191	fructose-bisphosphate aldolase activity
X953_17430	COG0504	CTP synthase activity
X953_17435	COG3343	RNA polymerase activity
X953_17450	COG1703	isobutyryl-CoA mutase activity
X953_17450	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
X953_17450	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
X953_17460	COG1703	isobutyryl-CoA mutase activity
X953_17465	COG1960	acyl-CoA dehydrogenase activity
X953_17470	COG1960	acyl-CoA dehydrogenase activity
X953_17475	COG1250	3-hydroxyacyl-CoA dehydrogenase
X953_17480	COG0183	Belongs to the thiolase family
X953_17485	COG2181	nitrate reductase activity
X953_17485	COG0247	lactate metabolic process
X953_17490	COG0018	arginyl-trna synthetase
X953_17505	COG0010	Belongs to the arginase family
X953_17515	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
X953_17525	COG3465	dGTPase activity
X953_17530	COG1078	dGTPase activity
X953_17535	COG0095	Lipoate-protein ligase
X953_17540	COG0280	phosphate acetyltransferase
X953_17565	COG2363	Small membrane protein
X953_17580	COG0069	glutamate synthase activity
X953_17610	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
X953_17615	COG1793	dna ligase
X953_17615	COG3285	dna ligase
X953_17625	COG1764	response to oxidative stress
X953_17640	COG3189	MarR family transcriptional regulator
X953_17645	COG0861	Integral membrane protein TerC family
X953_17650	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
X953_17655	COG0628	permease
X953_17675	COG1114	Component of the transport system for branched-chain amino acids
X953_17680	COG0514	ATP-dependent DNA helicase (RecQ)
X953_17690	COG1115	amino acid carrier protein
X953_17695	COG1607	acyl-coa hydrolase
X953_17700	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
X953_17705	COG0626	cystathionine gamma-synthase activity
X953_17710	COG2962	Rard protein
X953_17720	COG2755	lipolytic protein G-D-S-L family
X953_17725	COG4698	Protein conserved in bacteria
X953_17745	COG0488	(ABC) transporter
X953_17750	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
X953_17755	COG0156	8-amino-7-oxononanoate synthase activity
X953_17765	COG1388	LysM domain
X953_17765	COG3584	3D domain protein
X953_17765	COG3584	3D domain protein
X953_17765	COG1388	LysM domain
X953_17770	COG4086	secreted protein
X953_17775	COG2814	Major facilitator Superfamily
X953_17785	COG1979	alcohol dehydrogenase
X953_17790	COG0251	oxidation-reduction process
X953_17795	COG0741	lytic transglycosylase activity
X953_17805	COG0534	Mate efflux family protein
X953_17825	COG0318	PFAM AMP-dependent synthetase and ligase
X953_17830	COG4608	Belongs to the ABC transporter superfamily
X953_17835	COG0444	Belongs to the ABC transporter superfamily
X953_17840	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
X953_17845	COG0601	transmembrane transport
X953_17850	COG4166	transmembrane transport
X953_17870	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
X953_17875	COG2814	Major facilitator Superfamily
X953_17880	COG1737	Transcriptional regulator
X953_17885	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
X953_17890	COG2610	gluconate transmembrane transporter activity
X953_17895	COG1070	Carbohydrate kinase
X953_17905	COG1288	antiporter activity
X953_17910	COG2032	superoxide dismutase activity
X953_17920	COG1725	Transcriptional regulator
X953_17925	COG4152	abc transporter atp-binding protein
X953_17940	COG0655	NAD(P)H dehydrogenase (quinone) activity
X953_17945	COG4991	sh3 domain protein
X953_17945	COG3103	Sh3 type 3 domain protein
X953_17945	COG0860	N-Acetylmuramoyl-L-alanine amidase
X953_17955	COG2226	methyltransferase
X953_17975	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
X953_17995	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
X953_18005	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
X953_18010	COG0583	DNA-binding transcription factor activity
X953_18015	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
X953_18020	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
X953_18045	COG3246	L-lysine catabolic process to acetate
X953_18055	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
X953_18060	COG2323	membrane
X953_18065	COG0367	asparagine synthase
X953_18070	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
X953_18085	COG1115	amino acid carrier protein
X953_18100	COG2199	diguanylate cyclase activity
X953_18110	COG0820	rRNA (adenine-C2-)-methyltransferase activity
X953_18115	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
X953_18120	COG0655	NAD(P)H dehydrogenase (quinone) activity
X953_18125	COG0501	Belongs to the peptidase M48B family
X953_18130	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
X953_18135	COG2197	response regulator
X953_18140	COG4585	Histidine kinase
X953_18145	COG3239	Fatty acid desaturase
X953_18160	COG1199	ATP-dependent helicase activity
X953_18170	COG3279	Response regulator of the LytR AlgR family
X953_18180	COG1252	NADH dehydrogenase
X953_18190	COG1346	cytolysis
X953_18195	COG1380	Effector of murein hydrolase LrgA
X953_18200	COG0165	Argininosuccinate lyase
X953_18205	COG0137	argininosuccinate synthase activity
X953_18210	COG2076	Multidrug Resistance protein
X953_18215	COG2076	Multidrug Resistance protein
X953_18220	COG1309	transcriptional regulator
X953_18225	COG1028	Short-chain dehydrogenase reductase Sdr
X953_18230	COG1846	Transcriptional regulator
X953_18245	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
X953_18250	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
X953_18255	COG0573	inorganic phosphate transmembrane transporter activity
X953_18260	COG0581	inorganic phosphate transmembrane transporter activity
X953_18265	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
X953_18295	COG2323	membrane
X953_18310	COG2814	Major facilitator Superfamily
X953_18315	COG2404	hydrolase activity, acting on ester bonds
X953_18330	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
X953_18345	COG1621	beta-fructofuranosidase activity
X953_18350	COG2190	(PTS) system
X953_18355	COG3871	stress protein (general stress protein 26)
X953_18360	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
X953_18385	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
X953_18395	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
X953_18420	COG1607	acyl-coa hydrolase
X953_18445	COG0583	DNA-binding transcription factor activity
X953_18450	COG0725	ABC transporter, periplasmic molybdate-binding protein
X953_18455	COG4149	molybdate abc transporter
X953_18460	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
X953_18475	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
X953_18485	COG3711	transcriptional antiterminator
X953_18490	COG2190	(PTS) system
X953_18490	COG1263	PTS System
X953_18490	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
X953_18495	COG1393	Belongs to the ArsC family
X953_18515	COG1999	signal sequence binding
X953_18520	COG1349	DNA-binding transcription factor activity
X953_18535	COG0785	Cytochrome C biogenesis protein
X953_18540	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
X953_18545	COG0745	RESPONSE REGULATOR receiver
X953_18550	COG2205	protein histidine kinase activity
X953_18555	COG4412	M6 family metalloprotease domain protein
X953_18555	COG3291	Pkd domain containing protein
X953_18560	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
X953_18565	COG0730	response to heat
X953_18570	COG0425	Belongs to the sulfur carrier protein TusA family
X953_18575	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
X953_18575	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
X953_18580	COG2210	Belongs to the sulfur carrier protein TusA family
X953_18585	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
X953_18585	COG0425	Belongs to the sulfur carrier protein TusA family
X953_18590	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
X953_18595	COG2210	Belongs to the sulfur carrier protein TusA family
X953_18600	COG1937	Protein conserved in bacteria
X953_18610	COG4536	flavin adenine dinucleotide binding
X953_18630	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
X953_18640	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
X953_18640	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
X953_18645	COG0456	acetyltransferase
X953_18660	COG2719	SpoVR family
X953_18670	COG2718	Belongs to the UPF0229 family
X953_18675	COG1960	acyl-CoA dehydrogenase activity
X953_18680	COG1024	Enoyl-CoA hydratase
X953_18685	COG1250	3-hydroxyacyl-CoA dehydrogenase
X953_18690	COG0318	PFAM AMP-dependent synthetase and ligase
X953_18700	COG2045	Belongs to the ComB family
X953_18715	COG1309	transcriptional regulator
X953_18720	COG1028	Short-chain dehydrogenase reductase Sdr
X953_18735	COG2766	serine protein kinase
X953_18755	COG0270	DNA (cytosine-5-)-methyltransferase activity
X953_18770	COG0791	NLP P60 protein
X953_18770	COG1388	LysM domain
X953_18895	COG0740	serine-type endopeptidase activity
X953_18995	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
X953_19000	COG2766	serine protein kinase
X953_19045	COG1120	ATPase activity
X953_19050	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
X953_19055	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
X953_19060	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
X953_19090	COG1301	dicarboxylic acid transport
X953_19095	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
X953_19110	COG2814	Major facilitator Superfamily
X953_19115	COG0517	IMP dehydrogenase activity
X953_19120	COG1846	Transcriptional regulator
X953_19130	COG1349	DNA-binding transcription factor activity
X953_19135	COG1105	Belongs to the carbohydrate kinase PfkB family
X953_19140	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
X953_19140	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
X953_19140	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
X953_19155	COG1827	regulation of RNA biosynthetic process
X953_19160	COG0157	Belongs to the NadC ModD family
X953_19185	COG1366	Belongs to the anti-sigma-factor antagonist family
X953_19195	COG1028	Short-chain dehydrogenase reductase Sdr
X953_19205	COG0427	acetyl-CoA hydrolase
X953_19210	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
X953_19215	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
X953_19240	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
X953_19245	COG4943	cyclic-guanylate-specific phosphodiesterase activity
X953_19255	COG0666	response to abiotic stimulus
X953_19265	COG2807	transmembrane transport
X953_19270	COG0702	epimerase
X953_19275	COG1028	Short-chain dehydrogenase reductase Sdr
X953_19280	COG1510	regulation of RNA biosynthetic process
X953_19330	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
X953_19355	COG2003	Belongs to the UPF0758 family
X953_19390	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
X953_19400	COG3711	transcriptional antiterminator
X953_19400	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
X953_19405	COG1486	melibiose metabolic process
X953_19415	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
X953_19420	COG3394	polysaccharide catabolic process
X953_19425	COG1447	Phosphotransferase system cellobiose-specific component IIA
X953_19430	COG3876	Protein conserved in bacteria
X953_19435	COG1733	regulation of RNA biosynthetic process
X953_19455	COG3639	organic phosphonate transmembrane transporter activity
X953_19465	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
X953_19475	COG0737	Belongs to the 5'-nucleotidase family
X953_19485	COG1028	Short-chain dehydrogenase reductase Sdr
X953_19500	COG3773	Cell wall hydrolase
X953_19515	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
X953_19590	COG1028	Short-chain dehydrogenase reductase Sdr
X953_19600	COG1132	(ABC) transporter
X953_19610	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
X953_19615	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
X953_19620	COG4853	Protein conserved in bacteria
X953_19625	COG4863	YycH protein
X953_19630	COG5002	protein histidine kinase activity
X953_19635	COG0745	RESPONSE REGULATOR receiver
X953_19645	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
X953_19650	COG0305	Participates in initiation and elongation during chromosome replication
X953_19655	COG0359	binds to the 23S rRNA
X953_19660	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
X953_19665	COG4241	membrane
X953_19675	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
X953_19680	COG0629	single-stranded DNA binding
X953_19685	COG0360	Binds together with S18 to 16S ribosomal RNA
X953_19690	COG0012	GTP binding
X953_19695	COG4481	Protein conserved in bacteria
X953_19700	COG0668	transmembrane transport
X953_19705	COG3949	Membrane
X953_19725	COG1475	DNA binding
X953_19730	COG1192	Involved in chromosome partitioning
X953_19740	COG1475	DNA binding
X953_19745	COG0357	Ribosomal RNA small subunit methyltransferase G
X953_19750	COG0445	tRNA wobble uridine modification
X953_19755	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
X953_19765	COG1847	R3H domain protein
X953_19770	COG0706	membrane insertase activity
X953_19775	COG0594	ribonuclease P activity
X953_19890	COG3883	PFAM NLP P60 protein
X953_19890	COG0791	NLP P60 protein
X953_19905	COG0582	viral genome integration into host DNA