locus-tag	class	description
Vdis_0004	ENOG4105CI0	Citrate lyase
Vdis_0006	ENOG4106N3V	dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83)
Vdis_0007	ENOG4105C4H	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity)
Vdis_0009	ENOG4108R70	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity)
Vdis_0016	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
Vdis_0017	ENOG4107VMB	Beta-lactamase domain protein
Vdis_0019	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
Vdis_0023	ENOG4105CCP	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
Vdis_0027	ENOG4105C1N	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity)
Vdis_0031	ENOG4105CFB	Gamma-glutamyltranspeptidase (EC 2.3.2.2)
Vdis_0033	ENOG4108ESU	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane (By similarity)
Vdis_0034	ENOG4105E0A	ABC, transporter
Vdis_0035	ENOG4105WE2	aldehyde ferredoxin oxidoreductase
Vdis_0044	ENOG4108JIP	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit (By similarity)
Vdis_0046	ENOG4108UMA	3-octaprenyl-4-hydroxybenzoate carboxy-lyase
Vdis_0047	ENOG4107R56	PP-loop domain protein
Vdis_0052	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
Vdis_0055	ENOG4105CMZ	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity)
Vdis_0061	ENOG4107QTZ	amino acid
Vdis_0062	ENOG4107QTZ	amino acid
Vdis_0069	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
Vdis_0076	ENOG4105CSH	Transporter
Vdis_0079	ENOG4105DZH	s-adenosylmethionine synthetase (EC 2.5.1.6)
Vdis_0082	ENOG4108UJD	30S ribosomal protein S9
Vdis_0083	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
Vdis_0084	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
Vdis_0091	ENOG4105CHR	reductase
Vdis_0095	ENOG4108Z0R	Transferase
Vdis_0097	ENOG4107QJF	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity)
Vdis_0098	ENOG4105CN9	Peptidase m42 family protein
Vdis_0099	ENOG4105C7N	Xanthine uracil vitamin C permease
Vdis_0122	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
Vdis_0190	ENOG4105CBF	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity)
Vdis_0193	ENOG4105C0N	N-acetylglutamate semialdehyde dehydrogenase
Vdis_0196	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
Vdis_0197	ENOG4105C8Y	Acetylornithine aminotransferase
Vdis_0198	ENOG4107SDT	Homocitrate synthase
Vdis_0199	ENOG4107PP3	Acetylornithine deacetylase
Vdis_0200	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
Vdis_0202	ENOG4107U4Q	acetylglutamate kinase
Vdis_0203	ENOG4105CHM	Aminotransferase
Vdis_0204	ENOG4105C1M	carbamoyl-phosphate synthetase glutamine chain
Vdis_0205	ENOG4105CU6	carbamoyl-phosphate synthetase ammonia chain
Vdis_0206	ENOG4105CH7	arginosuccinase
Vdis_0211	ENOG4105CDH	Citrulline--aspartate ligase
Vdis_0212	ENOG4105D10	5-enolpyruvylshikimate-3-phosphate phospholyase
Vdis_0214	ENOG4105CQC	Prephenate dehydratase
Vdis_0215	ENOG4108JPM	phospho-2-dehydro-3-deoxyheptonate aldolase
Vdis_0216	ENOG4105D49	3-dehydroquinate synthase
Vdis_0217	ENOG4105E2X	shikimate dehydrogenase
Vdis_0219	ENOG4105D5I	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity)
Vdis_0220	ENOG4105C2V	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity)
Vdis_0221	ENOG4105CMY	5-enolpyruvylshikimate-3-phosphate synthase
Vdis_0223	ENOG4105DK0	Indole-3-glycerol phosphate synthase
Vdis_0224	ENOG4105F6H	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity)
Vdis_0225	ENOG4108JEB	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
Vdis_0226	ENOG4107QYG	anthranilate phosphoribosyltransferase
Vdis_0227	ENOG4108ZGB	N-(5'-phosphoribosyl)anthranilate isomerase
Vdis_0228	ENOG4105CRQ	synthase (Component I)
Vdis_0229	ENOG4105DDQ	anthranilate synthase
Vdis_0230	ENOG4108HRN	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity)
Vdis_0234	ENOG4105CD3	dihydroorotase
Vdis_0235	ENOG4105C3K	feS assembly ATPase SufC
Vdis_0236	ENOG4105DIW	FeS assembly protein SUFB
Vdis_0237	ENOG4105DIW	FeS assembly protein SUFB
Vdis_0239	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
Vdis_0240	ENOG4108UTW	Plays a role in the regulation of phosphate uptake
Vdis_0244	ENOG4105ECY	inositol monophosphatase
Vdis_0252	ENOG4105CEY	Amp-dependent synthetase and ligase
Vdis_0255	ENOG4108UKI	Enoyl-CoA hydratase
Vdis_0257	ENOG4105CHU	acetyl-coa acetyltransferase
Vdis_0258	ENOG4105DYT	3-hydroxyacyl-CoA dehydrogenase
Vdis_0260	ENOG4108JQ1	Dehydrogenase
Vdis_0261	ENOG4105C7K	acetolactate synthase
Vdis_0264	ENOG4105C1G	acyl-Coa dehydrogenase
Vdis_0270	ENOG41080HI	glycine oxidase
Vdis_0272	ENOG4108JQ0	Key enzyme in the regulation of glycerol uptake and metabolism (By similarity)
Vdis_0277	ENOG4105DKF	Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity)
Vdis_0278	ENOG4105DVY	radical SAM domain protein
Vdis_0281	ENOG4105C04	l-carnitine dehydratase bile acid-inducible protein F
Vdis_0283	ENOG4105CU5	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity)
Vdis_0284	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
Vdis_0285	ENOG4107QNK	)-transporter
Vdis_0294	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
Vdis_0298	ENOG4107QZB	decarboxylase
Vdis_0306	ENOG4108ZQD	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity)
Vdis_0307	ENOG4108K3F	N(2),N(2)-dimethylguanosine tRNA methyltransferase
Vdis_0309	ENOG4105E26	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity)
Vdis_0315	ENOG4105EAY	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
Vdis_0318	ENOG410902C	phosphohistidine phosphatase, SixA
Vdis_0321	ENOG4105EZY	Pyrroloquinoline quinone biosynthesis protein E
Vdis_0322	ENOG4105CY0	Metallo-Beta-Lactamase
Vdis_0323	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
Vdis_0332	ENOG4105EYF	MMPL domain protein
Vdis_0333	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
Vdis_0335	ENOG4105EUJ	GTP cyclohydrolase i
Vdis_0338	ENOG4108V1U	phospholipid-binding protein
Vdis_0348	ENOG4105CVM	Molybdenum cofactor synthesis domain protein
Vdis_0349	ENOG4105CEY	Amp-dependent synthetase and ligase
Vdis_0350	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
Vdis_0352	ENOG4105CBC	glutamate synthase
Vdis_0360	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
Vdis_0361	ENOG41082SA	50s ribosomal protein l29
Vdis_0364	ENOG4108JIQ	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit (By similarity)
Vdis_0366	ENOG4105C8N	cysteinyl-tRNA synthetase
Vdis_0369	ENOG41061GT	Aldolase
Vdis_0377	ENOG4105CTX	dehydratase
Vdis_0379	ENOG4105CF3	3-Hydroxyisobutyrate dehydrogenase
Vdis_0384	ENOG4105WE2	aldehyde ferredoxin oxidoreductase
Vdis_0390	ENOG4105CXK	mandelate racemase muconate lactonizing
Vdis_0391	ENOG4105CPQ	Dehydrogenase
Vdis_0394	ENOG4105C4U	4-methyl-5-beta-hydroxyethylthiazole kinase
Vdis_0397	ENOG4105BZ1	(ABC) transporter
Vdis_0400	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
Vdis_0407	ENOG4105CSH	Transporter
Vdis_0408	ENOG4105C10	Electron transfer flavoprotein
Vdis_0409	ENOG4105BZJ	Electron transfer flavoprotein
Vdis_0410	ENOG41090P5	ferredoxin-like protein
Vdis_0411	ENOG4105DWH	electron transfer flavoprotein-ubiquinone oxidoreductase
Vdis_0412	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
Vdis_0413	ENOG4105EPH	radical SAM domain protein
Vdis_0432	ENOG4105IDI	abc transporter atp-binding protein
Vdis_0436	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
Vdis_0458	ENOG4107R0E	Glycosyl transferase, family 2
Vdis_0460	ENOG4105E2K	Glycosyl transferase (Group 1
Vdis_0464	ENOG4105CXW	Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity)
Vdis_0467	ENOG4107T8Q	Glycosyl transferase (Group 1
Vdis_0469	ENOG4107R5M	Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity)
Vdis_0472	ENOG4105E2K	Glycosyl transferase (Group 1
Vdis_0491	ENOG4105D0I	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity)
Vdis_0492	ENOG4108IYU	L-aspartate oxidase
Vdis_0493	ENOG4105D18	nicotinate-nucleotide pyrophosphorylase
Vdis_0496	ENOG4105EM7	Selenocysteine-specific translation elongation factor
Vdis_0497	ENOG4108IIG	CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity)
Vdis_0498	ENOG4105CCX	Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity)
Vdis_0499	ENOG4108JPX	Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity)
Vdis_0500	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
Vdis_0522	ENOG4105WGB	oxidoreductase, delta subunit
Vdis_0523	ENOG4105D95	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity)
Vdis_0524	ENOG4105DDK	oxidoreductase, beta subunit
Vdis_0526	ENOG4105CQB	FAD linked oxidase domain protein
Vdis_0527	ENOG4105CQB	FAD linked oxidase domain protein
Vdis_0531	ENOG4105CQR	helicase
Vdis_0534	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
Vdis_0535	ENOG4105C54	Major Facilitator superfamily
Vdis_0538	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
Vdis_0545	ENOG4108URP	Dtdp-4-dehydrorhamnose 3,5-epimerase
Vdis_0550	ENOG4105CUT	histidyl-tRNA synthetase
Vdis_0573	ENOG4105CD9	Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity)
Vdis_0574	ENOG4108UHX	Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity)
Vdis_0577	ENOG4108HH9	Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR
Vdis_0578	ENOG4105C54	Major Facilitator superfamily
Vdis_0579	ENOG4105C12	Phosphoribosylglycinamide synthetase
Vdis_0580	ENOG4105C8V	SAICAR synthetase
Vdis_0581	ENOG4105CXB	phosphoribosylaminoimidazole synthetase
Vdis_0582	ENOG4105CBA	glutamine phosphoribosylpyrophosphate amidotransferase
Vdis_0584	ENOG4107QIK	phosphoribosylformylglycinamidine synthase
Vdis_0585	ENOG4108UM6	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity)
Vdis_0586	ENOG4105CY8	phosphoribosylaminoimidazole carboxylase atpase subunit
Vdis_0588	ENOG4105FD2	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity)
Vdis_0589	ENOG4105EIZ	Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity)
Vdis_0591	ENOG4108K7V	UPF0284 protein
Vdis_0592	ENOG4105CCG	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity)
Vdis_0596	ENOG4105CEK	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity)
Vdis_0597	ENOG4108UJE	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity)
Vdis_0598	ENOG4105K8F	Phosphoribosyl-amp cyclohydrolase
Vdis_0599	ENOG4105K8F	Phosphoribosyl-amp cyclohydrolase
Vdis_0600	ENOG4105C0S	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity)
Vdis_0601	ENOG4105ECC	imidazole-glycerol-phosphate dehydratase
Vdis_0602	ENOG4105CJV	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
Vdis_0603	ENOG4105E21	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity)
Vdis_0604	ENOG4105CIH	Imidazole acetol-phosphate transaminase
Vdis_0605	ENOG4105CSH	Transporter
Vdis_0607	ENOG4105D6E	homoserine dehydrogenase
Vdis_0608	ENOG4105CM3	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity)
Vdis_0609	ENOG4105CFH	Aspartokinase
Vdis_0614	ENOG4105DYA	Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity)
Vdis_0615	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
Vdis_0616	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
Vdis_0618	ENOG4105D6T	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity)
Vdis_0621	ENOG4108I0N	Transporter, RarD family, DMT superfamily protein
Vdis_0628	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
Vdis_0629	ENOG4108IYI	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity)
Vdis_0631	ENOG4107VRP	DNA repair exonuclease
Vdis_0632	ENOG4105EYH	Exonuclease
Vdis_0634	ENOG4105CD5	CoA-binding domain protein
Vdis_0642	ENOG4105CJ1	ABC, transporter
Vdis_0644	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
Vdis_0648	ENOG4107RHB	Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates (By similarity)
Vdis_0650	ENOG4107QRT	dEAD DEAH box helicase
Vdis_0657	ENOG4107QJE	Chromosome Partitioning Protein
Vdis_0660	ENOG410842T	Pterin carbinolamine dehydratase
Vdis_0668	ENOG4105CSH	Transporter
Vdis_0679	ENOG4108MYP	Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four- carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity)
Vdis_0681	ENOG4105CBC	glutamate synthase
Vdis_0682	ENOG4105EYU	Glutamine amido-transferase
Vdis_0683	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
Vdis_0685	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
Vdis_0686	ENOG4105C7K	acetolactate synthase
Vdis_0688	ENOG4105C6M	Alpha-keto-beta-hydroxylacyl reductoisomerase
Vdis_0692	ENOG4105EJ5	oxidoreductase gamma subunit
Vdis_0694	ENOG4105D95	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity)
Vdis_0695	ENOG4105DDK	oxidoreductase, beta subunit
Vdis_0696	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
Vdis_0699	ENOG4105MQS	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
Vdis_0700	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
Vdis_0703	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
Vdis_0704	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
Vdis_0708	ENOG4105EPU	Molybdenum cofactor synthesis domain protein
Vdis_0713	ENOG4105C8T	Leucyl-tRNA synthetase
Vdis_0714	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
Vdis_0717	ENOG4105CA9	Pyruvate kinase
Vdis_0720	ENOG4105EM7	Selenocysteine-specific translation elongation factor
Vdis_0722	ENOG4105BZU	Histidine kinase
Vdis_0723	ENOG4105C5F	glutamine synthetase
Vdis_0725	ENOG4105K63	Thioredoxin
Vdis_0729	ENOG4108Z4J	Cytidine monophosphate kinase
Vdis_0732	ENOG41074MP	UPF0103 Mediator of ErbB2-driven cell motility-containing protein
Vdis_0733	ENOG4105CE9	30S ribosomal protein S2
Vdis_0734	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
Vdis_0737	ENOG4105DR1	Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity)
Vdis_0741	ENOG4105C0M	Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity)
Vdis_0746	ENOG4105D06	uba thif-type nad fad binding protein
Vdis_0748	ENOG4105CZ5	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity)
Vdis_0757	ENOG4105M7V	2'-5' rna ligase
Vdis_0768	ENOG4108RCS	geranylgeranylglyceryl phosphate synthase
Vdis_0772	ENOG4107Z60	histidine triad (HIT) protein
Vdis_0775	ENOG4105CVM	Molybdenum cofactor synthesis domain protein
Vdis_0783	ENOG4105CSH	Transporter
Vdis_0795	ENOG4105D1E	Undecaprenyl pyrophosphate phosphatase
Vdis_0801	ENOG4105TRI	Hydrolase
Vdis_0803	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
Vdis_0804	ENOG4108UGV	hypoxanthine phosphoribosyltransferase
Vdis_0809	ENOG4107XGZ	Hydrolase
Vdis_0812	ENOG4105NBF	ammecr1 domain protein
Vdis_0818	ENOG4107Y70	Heat shock protein
Vdis_0820	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
Vdis_0829	ENOG4105DWH	electron transfer flavoprotein-ubiquinone oxidoreductase
Vdis_0830	ENOG4105C35	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity)
Vdis_0831	ENOG4105CTD	carboxy-peptidase
Vdis_0833	ENOG4105ED0	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity)
Vdis_0834	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
Vdis_0835	ENOG4108Z1Z	gCN5-related N-acetyltransferase
Vdis_0842	ENOG4105DGU	Histone deacetylase
Vdis_0844	ENOG4108ZEF	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)
Vdis_0846	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
Vdis_0850	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
Vdis_0877	ENOG4105CET	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity)
Vdis_0878	ENOG41082CS	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity)
Vdis_0888	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
Vdis_0901	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
Vdis_0911	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
Vdis_0913	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
Vdis_0917	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
Vdis_0922	ENOG4108V82	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
Vdis_0925	ENOG4107QRT	dEAD DEAH box helicase
Vdis_0931	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
Vdis_0932	ENOG4105C6K	Malic enzyme
Vdis_0934	ENOG4108XM1	transcriptional regulator AsnC family
Vdis_0935	ENOG4105CQ2	DNA polymerase
Vdis_0938	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
Vdis_0940	ENOG4105C22	threonyL-tRNA synthetase
Vdis_0943	ENOG4105F1R	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity)
Vdis_0965	ENOG4105E0I	Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity)
Vdis_0967	ENOG4108JPZ	Monovalent cation H antiporter subunit D
Vdis_0968	ENOG4105C8S	subunit m
Vdis_0969	ENOG4107QR9	Iron-sulfur cluster binding protein
Vdis_0970	ENOG4105D4F	Synthesizes selenophosphate from selenide and ATP (By similarity)
Vdis_0971	ENOG4105C7B	Threonine dehydratase
Vdis_0972	ENOG4105KME	endoribonuclease L-psp
Vdis_0975	ENOG4105CVM	Molybdenum cofactor synthesis domain protein
Vdis_0987	ENOG4105EZI	multiple antibiotic resistance (MarC)-related protein
Vdis_0989	ENOG4105C5S	asparaginyl-tRNA synthetase
Vdis_0994	ENOG4105CUB	amino acid
Vdis_0995	ENOG4105C1A	potassium transporter peripheral membrane
Vdis_0996	ENOG4105D7K	pfkb domain protein
Vdis_0999	ENOG4107SVH	Potassium channel protein
Vdis_1001	ENOG4105CMR	udp-glucose 4-epimerase
Vdis_1005	ENOG4105DH2	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity)
Vdis_1010	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
Vdis_1015	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
Vdis_1017	ENOG4105NDF	NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity)
Vdis_1021	ENOG4107SYB	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity)
Vdis_1025	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
Vdis_1031	ENOG4105X3E	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity)
Vdis_1032	ENOG41080HJ	6-phospho 3-hexuloisomerase
Vdis_1033	ENOG4105D5M	phosphate starvation-inducible protein
Vdis_1035	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Vdis_1042	ENOG4108RTV	Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity)
Vdis_1044	ENOG4108RW0	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity)
Vdis_1046	ENOG4105C28	cystathionine
Vdis_1059	ENOG4105DQU	oxidoreductase, subunit beta
Vdis_1069	ENOG4107T5V	SNARE associated Golgi
Vdis_1094	ENOG4105P3U	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
Vdis_1096	ENOG4105CH8	Succinyl-CoA ligase ADP-forming subunit alpha
Vdis_1097	ENOG4105CMV	Succinyl-CoA synthetase subunit beta
Vdis_1101	ENOG4105C3E	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity)
Vdis_1102	ENOG4108IJ9	(ABC) transporter
Vdis_1104	ENOG4105CXT	aspartate transcarbamylase
Vdis_1105	ENOG4108R9M	Involved in allosteric regulation of aspartate carbamoyltransferase (By similarity)
Vdis_1106	ENOG4107RIV	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
Vdis_1107	ENOG4107QYT	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity)
Vdis_1112	ENOG4105C5I	Dehydrogenase
Vdis_1116	ENOG4108I5U	Uridine phosphorylase
Vdis_1122	ENOG4105ETU	transcriptional activator (TenA
Vdis_1125	ENOG4108Q5Y	Membrane
Vdis_1127	ENOG4105C5X	domain protein
Vdis_1187	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
Vdis_1188	ENOG4105EYH	Exonuclease
Vdis_1199	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
Vdis_1201	ENOG4108R6G	acetyltransferase
Vdis_1202	ENOG4105E3H	phosphoglycerate mutase
Vdis_1203	ENOG4105VF7	tolerance protein
Vdis_1204	ENOG4108FN7	Aldo keto reductase
Vdis_1205	ENOG4108UV6	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity)
Vdis_1206	ENOG4105D64	Mechanosensitive ion channel
Vdis_1207	ENOG4105C3G	gtp-binding protein
Vdis_1208	ENOG4105C75	arginyL-tRNA synthetase
Vdis_1210	ENOG4108IIJ	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
Vdis_1211	ENOG4107QR0	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
Vdis_1212	ENOG4107QR0	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
Vdis_1217	ENOG4105D1H	recombination factor protein RarA
Vdis_1224	ENOG4105D7K	pfkb domain protein
Vdis_1225	ENOG4107RGD	Major Facilitator superfamily
Vdis_1230	ENOG4105CPC	Aldo Keto reductase
Vdis_1232	ENOG4105DJ5	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
Vdis_1240	ENOG41082K8	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity)
Vdis_1241	ENOG4105VSY	K01512 acylphosphatase EC 3.6.1.7
Vdis_1243	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
Vdis_1245	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
Vdis_1254	ENOG4105CP7	Triose-phosphate isomerase
Vdis_1256	ENOG4107QM5	aconitate hydratase
Vdis_1266	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
Vdis_1269	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
Vdis_1270	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
Vdis_1276	ENOG4105C1G	acyl-Coa dehydrogenase
Vdis_1277	ENOG4105D2B	acyl-CoA dehydrogenase
Vdis_1278	ENOG4105CEY	Amp-dependent synthetase and ligase
Vdis_1281	ENOG4105DYT	3-hydroxyacyl-CoA dehydrogenase
Vdis_1284	ENOG4105CV2	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity)
Vdis_1286	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
Vdis_1292	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
Vdis_1297	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
Vdis_1307	ENOG4107QTZ	amino acid
Vdis_1309	ENOG4105EW9	transcriptional regulator AsnC family
Vdis_1311	ENOG4105F8V	Hydrolase, tatD family
Vdis_1314	ENOG4105C6T	cysteine synthase
Vdis_1316	ENOG4108JPW	Aminotransferase
Vdis_1320	ENOG4105C4M	(Ubiquinol oxidase) subunit I
Vdis_1330	ENOG4105CEV	competence damage-inducible protein
Vdis_1331	ENOG4105CR7	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA (By similarity)
Vdis_1333	ENOG4108JQ1	Dehydrogenase
Vdis_1339	ENOG4105EFU	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity)
Vdis_1355	ENOG4108R96	Methyltransferase, YaeB family
Vdis_1360	ENOG4105C7Z	Conserved Protein
Vdis_1363	ENOG4105C9Q	fumarate hydratase class II
Vdis_1364	ENOG4105EUB	pirin domain protein
Vdis_1372	ENOG4105KHC	sulfurtransferase
Vdis_1375	ENOG4105CMS	peptidase U62, modulator of DNA gyrase
Vdis_1377	ENOG4105C3U	ABC transporter
Vdis_1379	ENOG4105DEF	Extracellular solute-binding protein, family 5
Vdis_1380	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
Vdis_1381	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
Vdis_1383	ENOG4107QTZ	amino acid
Vdis_1387	ENOG4105CE1	Ferrous iron transport protein b
Vdis_1389	ENOG4105D52	delta-aminolevulinic acid dehydratase
Vdis_1390	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
Vdis_1393	ENOG4105D1F	ATP-binding protein
Vdis_1394	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
Vdis_1401	ENOG4105F1A	Pyruvate formate-lyase
Vdis_1404	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Vdis_1412	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
Vdis_1414	ENOG4106UJV	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity)
Vdis_1416	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
Vdis_1426	ENOG4105CSH	Transporter
Vdis_1428	ENOG4105D3H	Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity)
Vdis_1440	ENOG4108IUE	nitrate reductase beta subunit
Vdis_1444	ENOG4105FJH	Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity)
Vdis_1447	ENOG4108R96	Methyltransferase, YaeB family
Vdis_1450	ENOG4105K78	MarR family Transcriptional regulator
Vdis_1454	ENOG4105DI2	Pyruvate flavodoxin ferredoxin oxidoreductase domain protein
Vdis_1455	ENOG4105DQU	oxidoreductase, subunit beta
Vdis_1458	ENOG4105CXK	mandelate racemase muconate lactonizing
Vdis_1460	ENOG4105CB2	alcohol dehydrogenase
Vdis_1463	ENOG4105CZA	synthase
Vdis_1465	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
Vdis_1466	ENOG4108YXW	Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
Vdis_1468	ENOG4105C66	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity)
Vdis_1474	ENOG4105C5S	asparaginyl-tRNA synthetase
Vdis_1477	ENOG4108J9M	Transporter
Vdis_1479	ENOG4108IUN	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity)
Vdis_1483	ENOG4105C1G	acyl-Coa dehydrogenase
Vdis_1491	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
Vdis_1496	ENOG4108JQ0	Key enzyme in the regulation of glycerol uptake and metabolism (By similarity)
Vdis_1497	ENOG4105C54	Major Facilitator superfamily
Vdis_1498	ENOG4108QXE	glycerophosphoryl diester phosphodiesterase
Vdis_1499	ENOG4107R5Y	anaerobic glycerol-3-phosphate dehydrogenase, subunit A
Vdis_1501	ENOG4105E8V	Alpha Beta Hydrolase Fold protein
Vdis_1508	ENOG4105DWH	electron transfer flavoprotein-ubiquinone oxidoreductase
Vdis_1509	ENOG4105CKK	Glycosyl transferase, family 2
Vdis_1511	ENOG41076HS	cation diffusion facilitator family transporter
Vdis_1517	ENOG4108RVA	ribokinase
Vdis_1519	ENOG4107TRG	DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair (By similarity)
Vdis_1520	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
Vdis_1525	ENOG4107Y49	methyltransferase
Vdis_1526	ENOG4105CD8	aminopeptidase N
Vdis_1529	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
Vdis_1530	ENOG4106HK8	GPR1 FUN34 yaaH family protein
Vdis_1532	ENOG41087GE	Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity)
Vdis_1534	ENOG4107V9E	glucose-1-phosphate thymidylyltransferase
Vdis_1562	ENOG4105Y7X	Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity)
Vdis_1565	ENOG4107QTZ	amino acid
Vdis_1582	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
Vdis_1591	ENOG4105DQU	oxidoreductase, subunit beta
Vdis_1595	ENOG4105E39	Enoyl-CoA hydratase
Vdis_1596	ENOG4105CQB	FAD linked oxidase domain protein
Vdis_1600	ENOG4105CSP	Major Facilitator Superfamily
Vdis_1605	ENOG4108JQ7	(ABC) transporter
Vdis_1606	ENOG4105C3U	ABC transporter
Vdis_1608	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
Vdis_1610	ENOG4105ETS	cytosine purines uracil thiamine allantoin
Vdis_1613	ENOG4105ED2	Beta-lactamase
Vdis_1616	ENOG4105CHM	Aminotransferase
Vdis_1619	ENOG4105CQX	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity)
Vdis_1620	ENOG4105CHR	reductase
Vdis_1627	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
Vdis_1630	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
Vdis_1633	ENOG4105C1G	acyl-Coa dehydrogenase
Vdis_1634	ENOG4105C1G	acyl-Coa dehydrogenase
Vdis_1635	ENOG4105E50	uracil-dna glycosylase
Vdis_1637	ENOG4105C31	Tryptophanyl-tRNA synthetase
Vdis_1639	ENOG4107NFR	Fructose-1,6-bisphosphatase
Vdis_1648	ENOG4105CXK	mandelate racemase muconate lactonizing
Vdis_1653	ENOG4105C26	Dehydrogenase
Vdis_1656	ENOG4105E26	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity)
Vdis_1659	ENOG4108I5U	Uridine phosphorylase
Vdis_1661	ENOG4105C1J	atp-dependent rna helicase
Vdis_1664	ENOG4106XMA	In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity)
Vdis_1675	ENOG4105CY0	Metallo-Beta-Lactamase
Vdis_1687	ENOG4105FBQ	ATPase associated with various cellular activities aaa_5
Vdis_1703	ENOG4108YXY	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
Vdis_1705	ENOG4105CKX	Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP
Vdis_1710	ENOG41079KZ	Major Facilitator Superfamily
Vdis_1716	ENOG4105EAH	synthase
Vdis_1728	ENOG4105CF4	DegT DnrJ EryC1 StrS aminotransferase
Vdis_1732	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
Vdis_1739	ENOG4105DKT	Transcriptional regulator
Vdis_1741	ENOG4105DC7	peptidase M24
Vdis_1745	ENOG4105C31	Tryptophanyl-tRNA synthetase
Vdis_1748	ENOG4105C6M	Alpha-keto-beta-hydroxylacyl reductoisomerase
Vdis_1749	ENOG4105D6W	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity)
Vdis_1752	ENOG4105D44	asparaginase
Vdis_1753	ENOG4107SYB	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity)
Vdis_1758	ENOG4105EK0	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
Vdis_1759	ENOG4105VG1	fes assembly suf system protein
Vdis_1762	ENOG4105CIF	Ornithine Cyclodeaminase
Vdis_1766	ENOG4105CAS	nag kinase
Vdis_1773	ENOG4105CEP	NADH dehydrogenase
Vdis_1775	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
Vdis_1779	ENOG4105F4R	Transcriptional regulator mode
Vdis_1783	ENOG4108UMS	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase (By similarity)
Vdis_1789	ENOG4105EJF	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity)
Vdis_1790	ENOG4105VSY	K01512 acylphosphatase EC 3.6.1.7
Vdis_1796	ENOG4107QIW	Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity)
Vdis_1798	ENOG4105EFZ	amidohydrolase
Vdis_1804	ENOG4105D1Z	hydroxypyruvate reductase
Vdis_1806	ENOG4107QTZ	amino acid
Vdis_1812	ENOG4105W49	UPF0434 protein
Vdis_1817	ENOG4108VA3	3-hexulose-6-phosphate synthase
Vdis_1822	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
Vdis_1825	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
Vdis_1836	ENOG4105CQ2	DNA polymerase
Vdis_1838	ENOG4108VTU	Cdp-alcohol phosphatidyltransferase
Vdis_1840	ENOG4105D82	Glutamate dehydrogenase
Vdis_1845	ENOG4105BZN	citrate synthase
Vdis_1850	ENOG4105DYA	Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity)
Vdis_1855	ENOG4105X3E	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity)
Vdis_1858	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
Vdis_1868	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
Vdis_1869	ENOG4105DHP	deoxycytidine triphosphate deaminase
Vdis_1871	ENOG4105C7B	Threonine dehydratase
Vdis_1875	ENOG4108V1J	Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity)
Vdis_1880	ENOG4105ET3	Reduction of activated sulfate into sulfite (By similarity)
Vdis_1887	ENOG4107EPV	Aminotransferase class V
Vdis_1889	ENOG4105DXD	2-methylcitrate dehydratase
Vdis_1890	ENOG4105DC6	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity)
Vdis_1893	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
Vdis_1896	ENOG4107R7Y	intracellular protease Pfpi family
Vdis_1897	ENOG4105ERH	Fumarylacetoacetate hydrolase
Vdis_1898	ENOG4108RW0	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity)
Vdis_1899	ENOG4108IUW	ABC transporter
Vdis_1903	ENOG4105CTK	cobaltochelatase, cobn subunit
Vdis_1904	ENOG4105EET	magnesium chelatase
Vdis_1905	ENOG4108IPX	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity)
Vdis_1906	ENOG4105EHG	Permease protein
Vdis_1909	ENOG4105CIA	precorrin-4 C(11)-methyltransferase
Vdis_1911	ENOG4107XSI	cobalt-precorrin-6y C15-methyltransferase
Vdis_1912	ENOG4105EE8	May catalyze the methylation of C-1 in cobalt-precorrin- 5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A (By similarity)
Vdis_1913	ENOG4105E4R	Precorrin-3B C17-methyltransferase
Vdis_1914	ENOG41081F0	Precorrin-8x methylmutase
Vdis_1915	ENOG4105CIA	precorrin-4 C(11)-methyltransferase
Vdis_1921	ENOG4107EXU	Short-chain dehydrogenase reductase Sdr
Vdis_1923	ENOG4105CR4	methylisocitrate lyase
Vdis_1924	ENOG4105DYT	3-hydroxyacyl-CoA dehydrogenase
Vdis_1926	ENOG41066FR	extracellular solute-binding protein
Vdis_1931	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
Vdis_1932	ENOG4105D9H	Catalyzes the attachment of glycine to tRNA(Gly) (By similarity)
Vdis_1933	ENOG4105CYW	agmatinase
Vdis_1935	ENOG4105EJ5	oxidoreductase gamma subunit
Vdis_1937	ENOG4105D95	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity)
Vdis_1938	ENOG4105DDK	oxidoreductase, beta subunit
Vdis_1943	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
Vdis_1948	ENOG4105CEY	Amp-dependent synthetase and ligase
Vdis_1949	ENOG4105CGK	Exodeoxyribonuclease III
Vdis_1954	ENOG4108UN4	phage SPO1 DNA polymerase-related protein
Vdis_1956	ENOG4105DFT	pur operon repressor
Vdis_1958	ENOG4108V1U	phospholipid-binding protein
Vdis_1959	ENOG4107TIA	phenylalanyl-tRNA synthetase (beta subunit)
Vdis_1969	ENOG4105CSS	phenylalanyl-tRNA synthetase (alpha subunit)
Vdis_1970	ENOG4105BZJ	Electron transfer flavoprotein
Vdis_1971	ENOG4105C10	Electron transfer flavoprotein
Vdis_1972	ENOG4105DF6	Fe-S oxidoreductase
Vdis_1976	ENOG4105CN9	Peptidase m42 family protein
Vdis_1977	ENOG4105DGA	Diaminopimelate dehydrogenase
Vdis_1978	ENOG4105BZA	Phosphoglycerate kinase
Vdis_1983	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
Vdis_1984	ENOG4108NGU	Transcriptional regulator
Vdis_1985	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
Vdis_1987	ENOG4105D95	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity)
Vdis_1992	ENOG4105C59	p-type ATPase
Vdis_1997	ENOG4105C50	Binding-protein-dependent transport systems, inner membrane component
Vdis_1998	ENOG4105D56	permease protein
Vdis_2007	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
Vdis_2011	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
Vdis_2020	ENOG4105DBV	ornithine carbamoyltransferase
Vdis_2025	ENOG4107RA1	nh(3)-dependent nad( ) synthetase
Vdis_2026	ENOG4105C4K	Nad synthetase
Vdis_2027	ENOG4108HMX	isocitrate dehydrogenase (NADP)
Vdis_2031	ENOG4105P8F	nudix hydrolase
Vdis_2034	ENOG4105CPQ	Dehydrogenase
Vdis_2035	ENOG4108UGX	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity)
Vdis_2036	ENOG4105CDM	Glutamate-1-semialdehyde aminotransferase
Vdis_2037	ENOG4105C7E	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity)
Vdis_2038	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
Vdis_2039	ENOG4105D8I	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity)
Vdis_2046	ENOG4108JQ7	(ABC) transporter
Vdis_2047	ENOG4105C3U	ABC transporter
Vdis_2049	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
Vdis_2065	ENOG4108ZKT	aldose 1-epimerase
Vdis_2083	ENOG4105C0Y	Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity)
Vdis_2084	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
Vdis_2088	ENOG4107RIQ	Sulfate adenylate transferase
Vdis_2094	ENOG4105D0D	Nitrate reductase 2, gamma subunit
Vdis_2099	ENOG4105PJW	Sulfite reductase dissimilatory-type beta subunit
Vdis_2101	ENOG4108Z0T	Part of a sulfur-relay system (By similarity)
Vdis_2105	ENOG4105CV8	reductase
Vdis_2113	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
Vdis_2114	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
Vdis_2115	ENOG4105CRD	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity)
Vdis_2116	ENOG4105F0Z	galactose-1-phosphate uridylyltransferase
Vdis_2117	ENOG4105C3M	thioredoxin reductase
Vdis_2120	ENOG4107S7U	Sulfide dehydrogenase
Vdis_2122	ENOG4108ZCA	Inherit from COG: pyridine nucleotide-disulfide oxidoreductase
Vdis_2129	ENOG4105CAY	ferredoxin--nadp reductase
Vdis_2130	ENOG4105C91	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
Vdis_2139	ENOG4105CHG	glycolate oxidase (iron-sulfur subunit)
Vdis_2140	ENOG4105CQB	FAD linked oxidase domain protein
Vdis_2144	ENOG4105CJW	magnesium transporter
Vdis_2146	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
Vdis_2155	ENOG4105CNR	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
Vdis_2165	ENOG4105QA4	4Fe-4S Ferredoxin, iron-sulfur binding domain protein
Vdis_2166	ENOG4105DB1	molybdopterin oxidoreductase
Vdis_2167	ENOG4105DVI	reductase, NrfD
Vdis_2176	ENOG4105DCX	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity)
Vdis_2177	ENOG4105F4R	Transcriptional regulator mode
Vdis_2179	ENOG41067S4	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity)
Vdis_2181	ENOG4105D3R	alkyl hydroperoxide reductase
Vdis_2193	ENOG4107UA9	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity)
Vdis_2200	ENOG4105C1A	potassium transporter peripheral membrane
Vdis_2201	ENOG4105KG3	cytidine deaminase
Vdis_2205	ENOG4106C6A	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
Vdis_2206	ENOG4105C9W	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity)
Vdis_2211	ENOG4107QHU	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
Vdis_2212	ENOG4108JEB	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
Vdis_2215	ENOG4105C1G	acyl-Coa dehydrogenase
Vdis_2216	ENOG4105CEY	Amp-dependent synthetase and ligase
Vdis_2227	ENOG4105WCJ	ec 1.1.1.193
Vdis_2231	ENOG4106NZV	Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity)
Vdis_2235	ENOG4105EQW	The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity)
Vdis_2237	ENOG4105EN6	Membrane
Vdis_2239	ENOG4105IU0	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
Vdis_2241	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
Vdis_2246	ENOG4105CHT	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
Vdis_2247	ENOG4107TE1	transport protein
Vdis_2249	ENOG4108RAC	Rubrerythrin
Vdis_2250	ENOG4105G5W	regulator Fur family
Vdis_2251	ENOG4105CHU	acetyl-coa acetyltransferase
Vdis_2253	ENOG4105EHU	Circadian clock protein KaiC
Vdis_2265	ENOG4107R56	PP-loop domain protein
Vdis_2269	ENOG4106K5Q	Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication (By similarity)
Vdis_2276	ENOG4105DI2	Pyruvate flavodoxin ferredoxin oxidoreductase domain protein
Vdis_2277	ENOG4105DQU	oxidoreductase, subunit beta
Vdis_2279	ENOG4105EWK	phytoene
Vdis_2280	ENOG4105DF6	Fe-S oxidoreductase
Vdis_2281	ENOG4105C10	Electron transfer flavoprotein
Vdis_2282	ENOG4105BZJ	Electron transfer flavoprotein
Vdis_2285	ENOG4105C0H	protease
Vdis_2287	ENOG4105CB9	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
Vdis_2289	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
Vdis_2290	ENOG4105CRD	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity)
Vdis_2299	ENOG4108IUW	ABC transporter
Vdis_2301	ENOG4105C5S	asparaginyl-tRNA synthetase
Vdis_2304	ENOG4105K4C	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity)
Vdis_2308	ENOG4105DPX	Hydrogenase, large subunit
Vdis_2320	ENOG4105E8R	UPF0173 metal-dependent hydrolase
Vdis_2321	ENOG4105D9G	High-affinity
Vdis_2325	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
Vdis_2328	ENOG4105CPQ	Dehydrogenase
Vdis_2332	ENOG4107GFK	fumarate
Vdis_2333	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
Vdis_2334	ENOG4105C26	Dehydrogenase
Vdis_2336	ENOG41087AY	ADP-Ribose pyrophosphatase
Vdis_2337	ENOG4105CSM	endonuclease III
Vdis_2338	ENOG4105KPK	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity)
Vdis_2339	ENOG41090X3	Peptidyl-prolyl cis-trans isomerase
Vdis_2342	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
Vdis_2344	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
Vdis_2355	ENOG4105F8V	Hydrolase, tatD family
Vdis_2361	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
Vdis_2362	ENOG4105D3H	Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity)
Vdis_2363	ENOG4105CXK	mandelate racemase muconate lactonizing
Vdis_2373	ENOG4105IQJ	Involved in biosynthesis of the thiamine precursor thiazole (By similarity)
Vdis_2376	ENOG4105K63	Thioredoxin
Vdis_2377	ENOG4108JPW	Aminotransferase
Vdis_2378	ENOG4105CD5	CoA-binding domain protein
Vdis_2379	ENOG4105CD5	CoA-binding domain protein
Vdis_2380	ENOG4105D0M	Protease HtpX homolog
Vdis_2389	ENOG41086CI	Bifunctional phosphoglucose phosphomannose isomerase
Vdis_2391	ENOG4105CM2	brancheD-chain amino acid aminotransferase
Vdis_2392	ENOG4105DS7	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity)
Vdis_2396	ENOG41076UM	multiple antibiotic resistance (MarC)-related protein
Vdis_2402	ENOG4105DWF	phosphomethylpyrimidine kinase
Vdis_2409	ENOG4105PEJ	SchA CurD domain protein
Vdis_2411	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
Vdis_2413	ENOG4105DRY	peptidase s9 prolyl oligopeptidase active site domain protein
Vdis_2418	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
Vdis_2419	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
Vdis_2435	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
Vdis_2437	ENOG4105D3W	isochorismatase
Vdis_2439	ENOG4105CDM	Glutamate-1-semialdehyde aminotransferase
Vdis_2442	ENOG4105CHR	reductase
Vdis_2447	ENOG4105HDK	L-asparaginase
Vdis_2449	ENOG4107QIW	Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity)
Vdis_2456	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
Vdis_2459	ENOG4105IES	Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity)
Vdis_2463	ENOG4105CHR	reductase
Vdis_2464	ENOG4105ETU	transcriptional activator (TenA
Vdis_2470	ENOG4105C1G	acyl-Coa dehydrogenase
Vdis_2475	ENOG4105CGP	Urocanate hydratase
Vdis_2477	ENOG4105D63	family UPF0324
Vdis_2480	ENOG4105CYW	agmatinase
Vdis_2483	ENOG4105CK4	Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity)
Vdis_2486	ENOG4105EEI	dihydropteroate synthase
Vdis_2487	ENOG4105E66	phosphoriboisomerase A
Vdis_2488	ENOG4105C84	Histidine ammonia-lyase
Vdis_2490	ENOG4107QTZ	amino acid
Vdis_2491	ENOG4105C7B	Threonine dehydratase
Vdis_2492	ENOG4105CHM	Aminotransferase
Vdis_2494	ENOG4105CX6	glutaminyL-tRNA synthetase
Vdis_2495	ENOG4105CI2	imidazolone-5-propionate hydrolase
Vdis_2509	ENOG4105CXK	mandelate racemase muconate lactonizing
Vdis_2510	ENOG4105FCI	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity)
Vdis_2511	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
Vdis_2520	ENOG4108K16	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
Vdis_2525	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
Vdis_2527	ENOG4105C2X	Arabinose 5-phosphate isomerase
Vdis_2531	ENOG4105K85	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity)