locus-tag	class	description
Vdis_0006	COG0463	Glycosyl transferase, family 2
Vdis_0007	COG0116	Belongs to the methyltransferase superfamily
Vdis_0007	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
Vdis_0009	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
Vdis_0016	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
Vdis_0017	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Vdis_0019	COG0081	regulation of translation
Vdis_0023	COG0552	protein localization to endoplasmic reticulum
Vdis_0023	COG0457	Tetratricopeptide repeat
Vdis_0027	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
Vdis_0031	COG0405	Gamma-glutamyltransferase
Vdis_0033	COG4139	cobalamin transport
Vdis_0034	COG1120	ATPase activity
Vdis_0035	COG2414	aldehyde ferredoxin oxidoreductase
Vdis_0044	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
Vdis_0047	COG0037	tRNA processing
Vdis_0049	COG0525	valine-tRNA ligase activity
Vdis_0052	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Vdis_0061	COG0531	amino acid
Vdis_0062	COG0531	amino acid
Vdis_0079	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
Vdis_0082	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Vdis_0083	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
Vdis_0084	COG0200	Binds to the 23S rRNA
Vdis_0091	COG1028	Short-chain dehydrogenase reductase Sdr
Vdis_0097	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Vdis_0098	COG1363	Peptidase, m42
Vdis_0099	COG2252	PERMEase
Vdis_0122	COG2226	methyltransferase
Vdis_0166	COG0433	COG0433 Predicted ATPase
Vdis_0190	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
Vdis_0193	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
Vdis_0196	COG0189	ligase activity
Vdis_0197	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Vdis_0198	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Vdis_0199	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Vdis_0200	COG0189	ligase activity
Vdis_0202	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
Vdis_0204	COG0505	Belongs to the CarA family
Vdis_0205	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
Vdis_0206	COG0165	Argininosuccinate lyase
Vdis_0211	COG0137	argininosuccinate synthase activity
Vdis_0212	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
Vdis_0214	COG1605	Chorismate mutase
Vdis_0214	COG0077	Prephenate dehydratase
Vdis_0215	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
Vdis_0216	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
Vdis_0217	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
Vdis_0219	COG0083	homoserine kinase activity
Vdis_0220	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
Vdis_0221	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
Vdis_0223	COG0134	indole-3-glycerol-phosphate synthase activity
Vdis_0224	COG0159	tryptophan synthase activity
Vdis_0225	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
Vdis_0226	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Vdis_0227	COG0135	phosphoribosylanthranilate isomerase activity
Vdis_0228	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
Vdis_0229	COG0512	Glutamine amidotransferase of anthranilate synthase
Vdis_0229	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Vdis_0230	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Vdis_0230	COG0574	Belongs to the PEP-utilizing enzyme family
Vdis_0234	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
Vdis_0235	COG0396	ATPase activity
Vdis_0236	COG0719	Fe-S assembly protein
Vdis_0237	COG0719	Fe-S assembly protein
Vdis_0239	COG2226	methyltransferase
Vdis_0240	COG0704	Plays a role in the regulation of phosphate uptake
Vdis_0244	COG0483	inositol monophosphate 1-phosphatase activity
Vdis_0252	COG0318	PFAM AMP-dependent synthetase and ligase
Vdis_0255	COG1024	Enoyl-CoA hydratase
Vdis_0257	COG0183	Belongs to the thiolase family
Vdis_0258	COG1250	3-hydroxyacyl-CoA dehydrogenase
Vdis_0260	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Vdis_0261	COG0028	Belongs to the TPP enzyme family
Vdis_0264	COG1960	acyl-CoA dehydrogenase activity
Vdis_0270	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Vdis_0272	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
Vdis_0273	COG0277	FAD linked oxidase domain protein
Vdis_0277	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
Vdis_0278	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
Vdis_0281	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Vdis_0283	COG0019	diaminopimelate decarboxylase activity
Vdis_0284	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
Vdis_0285	COG2814	Major facilitator Superfamily
Vdis_0294	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
Vdis_0298	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Vdis_0306	COG0237	dephospho-CoA kinase activity
Vdis_0307	COG1867	N(2),N(2)-dimethylguanosine tRNA methyltransferase
Vdis_0309	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
Vdis_0315	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
Vdis_0318	COG2062	phosphohistidine phosphatase, SixA
Vdis_0321	COG0535	radical SAM domain protein
Vdis_0322	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
Vdis_0323	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Vdis_0332	COG2409	Drug exporters of the RND superfamily
Vdis_0333	COG1136	(ABC) transporter
Vdis_0338	COG1881	PFAM PEBP family protein
Vdis_0348	COG0303	'Molybdopterin
Vdis_0349	COG0318	PFAM AMP-dependent synthetase and ligase
Vdis_0350	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Vdis_0352	COG0069	glutamate synthase activity
Vdis_0360	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
Vdis_0361	COG0255	Belongs to the universal ribosomal protein uL29 family
Vdis_0364	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
Vdis_0366	COG0215	cysteine-tRNA ligase activity
Vdis_0369	COG1830	Aldolase
Vdis_0377	COG2721	sulfolactate sulfo-lyase activity
Vdis_0379	COG2084	Dehydrogenase
Vdis_0384	COG2414	aldehyde ferredoxin oxidoreductase
Vdis_0390	COG4948	Mandelate Racemase Muconate Lactonizing
Vdis_0391	COG1063	alcohol dehydrogenase
Vdis_0394	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
Vdis_0400	COG1136	(ABC) transporter
Vdis_0406	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
Vdis_0407	COG0477	Major facilitator Superfamily
Vdis_0408	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
Vdis_0409	COG2086	electron transfer activity
Vdis_0411	COG0644	oxidoreductase
Vdis_0413	COG1032	radical SAM domain protein
Vdis_0432	COG1716	ATPase activity
Vdis_0432	COG0842	Transport permease protein
Vdis_0432	COG1131	(ABC) transporter
Vdis_0436	COG0714	Associated with various cellular activities
Vdis_0458	COG0463	Glycosyl transferase, family 2
Vdis_0460	COG0438	transferase activity, transferring glycosyl groups
Vdis_0464	COG0297	glycogen (starch) synthase activity
Vdis_0469	COG0438	transferase activity, transferring glycosyl groups
Vdis_0472	COG0438	transferase activity, transferring glycosyl groups
Vdis_0485	COG1215	transferase activity, transferring glycosyl groups
Vdis_0491	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
Vdis_0492	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
Vdis_0493	COG0157	Belongs to the NadC ModD family
Vdis_0496	COG3276	selenocysteine insertion sequence binding
Vdis_0498	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
Vdis_0500	COG2226	methyltransferase
Vdis_0522	COG1144	Oxidoreductase
Vdis_0523	COG0674	pyruvate-flavodoxin oxidoreductase activity
Vdis_0524	COG1013	pyruvate-flavodoxin oxidoreductase activity
Vdis_0526	COG0277	FAD linked oxidase domain protein
Vdis_0527	COG0277	FAD linked oxidase domain protein
Vdis_0531	COG4581	dead DEAH box helicase
Vdis_0534	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Vdis_0535	COG2814	Major facilitator Superfamily
Vdis_0538	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
Vdis_0550	COG0124	histidyl-tRNA synthetase
Vdis_0573	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
Vdis_0574	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
Vdis_0577	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
Vdis_0578	COG0477	Major facilitator Superfamily
Vdis_0579	COG0151	Belongs to the GarS family
Vdis_0580	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
Vdis_0581	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
Vdis_0582	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
Vdis_0583	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
Vdis_0584	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Vdis_0585	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
Vdis_0586	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
Vdis_0588	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
Vdis_0589	COG0602	queuosine metabolic process
Vdis_0590	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
Vdis_0591	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
Vdis_0592	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
Vdis_0596	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
Vdis_0597	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
Vdis_0598	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
Vdis_0598	COG0140	phosphoribosyl-ATP diphosphatase activity
Vdis_0599	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
Vdis_0600	COG0107	imidazoleglycerol-phosphate synthase activity
Vdis_0601	COG0131	Imidazoleglycerol-phosphate dehydratase
Vdis_0602	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
Vdis_0603	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
Vdis_0605	COG0477	Major facilitator Superfamily
Vdis_0608	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
Vdis_0609	COG0527	aspartate kinase activity
Vdis_0614	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
Vdis_0615	COG0519	Catalyzes the synthesis of GMP from XMP
Vdis_0615	COG0518	GMP synthase (glutamine-hydrolyzing) activity
Vdis_0628	COG0517	IMP dehydrogenase activity
Vdis_0628	COG0516	GMP reductase activity
Vdis_0629	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
Vdis_0631	COG0420	3'-5' exonuclease activity
Vdis_0632	COG0419	ATPase involved in DNA repair
Vdis_0642	COG1131	(ABC) transporter
Vdis_0644	COG1185	polyribonucleotide nucleotidyltransferase activity
Vdis_0646	COG0023	Translation Initiation Factor
Vdis_0648	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
Vdis_0650	COG1201	RNA secondary structure unwinding
Vdis_0657	COG1192	Involved in chromosome partitioning
Vdis_0668	COG0477	Major facilitator Superfamily
Vdis_0679	COG1892	Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four- carbon dicarboxylic acid source for the tricarboxylic acid cycle
Vdis_0680	COG1605	Chorismate mutase
Vdis_0680	COG0077	Prephenate dehydratase
Vdis_0681	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
Vdis_0681	COG0069	glutamate synthase activity
Vdis_0682	COG0067	glutamate synthase
Vdis_0683	COG0473	3-isopropylmalate dehydrogenase activity
Vdis_0685	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Vdis_0686	COG0028	Belongs to the TPP enzyme family
Vdis_0688	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
Vdis_0692	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Vdis_0694	COG0674	pyruvate-flavodoxin oxidoreductase activity
Vdis_0695	COG1013	pyruvate-flavodoxin oxidoreductase activity
Vdis_0696	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
Vdis_0699	COG0066	3-isopropylmalate dehydratase activity
Vdis_0700	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Vdis_0703	COG0051	transcription antitermination factor activity, RNA binding
Vdis_0704	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Vdis_0708	COG0521	Mo-molybdopterin cofactor biosynthetic process
Vdis_0714	COG0517	IMP dehydrogenase activity
Vdis_0714	COG0516	GMP reductase activity
Vdis_0717	COG0469	pyruvate kinase activity
Vdis_0722	COG0004	ammonium transporteR
Vdis_0723	COG0174	glutamine synthetase
Vdis_0725	COG3118	belongs to the thioredoxin family
Vdis_0729	COG1102	Psort location Cytoplasmic, score
Vdis_0732	COG1355	regulation of microtubule-based process
Vdis_0733	COG0052	Belongs to the universal ribosomal protein uS2 family
Vdis_0734	COG0148	phosphopyruvate hydratase activity
Vdis_0737	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
Vdis_0737	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
Vdis_0741	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
Vdis_0746	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
Vdis_0748	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
Vdis_0757	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
Vdis_0768	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
Vdis_0772	COG0537	adenosine 5'-monophosphoramidase activity
Vdis_0775	COG0303	'Molybdopterin
Vdis_0783	COG0477	Major facilitator Superfamily
Vdis_0794	COG1121	(ABC) transporter
Vdis_0795	COG0671	phosphoesterase, PA-phosphatase related
Vdis_0801	COG0561	phosphatase activity
Vdis_0803	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Vdis_0809	COG0546	phosphoglycolate phosphatase activity
Vdis_0812	COG2078	PFAM AMMECR1 domain protein
Vdis_0818	COG0071	Belongs to the small heat shock protein (HSP20) family
Vdis_0820	COG2264	protein methyltransferase activity
Vdis_0829	COG0644	oxidoreductase
Vdis_0831	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
Vdis_0833	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
Vdis_0834	COG1185	polyribonucleotide nucleotidyltransferase activity
Vdis_0835	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
Vdis_0844	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
Vdis_0846	COG1185	polyribonucleotide nucleotidyltransferase activity
Vdis_0850	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
Vdis_0870	COG1215	transferase activity, transferring glycosyl groups
Vdis_0877	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
Vdis_0878	COG0746	molybdenum cofactor guanylyltransferase activity
Vdis_0880	COG0123	including yeast histone deacetylase and acetoin utilization protein
Vdis_0901	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
Vdis_0911	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
Vdis_0913	COG0200	Binds to the 23S rRNA
Vdis_0917	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
Vdis_0922	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
Vdis_0925	COG1201	RNA secondary structure unwinding
Vdis_0931	COG3842	ATPase activity
Vdis_0932	COG0281	malic enzyme
Vdis_0934	COG1522	sequence-specific DNA binding
Vdis_0935	COG0417	DNA replication proofreading
Vdis_0938	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
Vdis_0940	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
Vdis_0943	COG0109	protoheme IX farnesyltransferase activity
Vdis_0965	COG1444	tRNA N-acetyltransferase activity
Vdis_0967	COG0651	ATP synthesis coupled electron transport
Vdis_0968	COG2111	Na H antiporter
Vdis_0968	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
Vdis_0969	COG1139	Iron-sulfur cluster binding protein
Vdis_0970	COG0709	Synthesizes selenophosphate from selenide and ATP
Vdis_0971	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
Vdis_0987	COG2095	MarC family integral membrane protein
Vdis_0988	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
Vdis_0994	COG0531	amino acid
Vdis_0995	COG0569	domain protein
Vdis_0999	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
Vdis_1001	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
Vdis_1010	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
Vdis_1015	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Vdis_1015	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Vdis_1017	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
Vdis_1021	COG0402	S-adenosylhomocysteine deaminase activity
Vdis_1025	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
Vdis_1029	COG0433	COG0433 Predicted ATPase
Vdis_1031	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
Vdis_1032	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
Vdis_1033	COG1702	phosphate starvation-inducible protein PhoH
Vdis_1042	COG0456	acetyltransferase
Vdis_1044	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Vdis_1047	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
Vdis_1059	COG1013	pyruvate-flavodoxin oxidoreductase activity
Vdis_1069	COG0586	Pfam SNARE associated Golgi protein
Vdis_1094	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Vdis_1096	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
Vdis_1097	COG0045	succinate-CoA ligase (ADP-forming) activity
Vdis_1101	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
Vdis_1102	COG3842	ATPase activity
Vdis_1104	COG0540	Belongs to the ATCase OTCase family
Vdis_1105	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
Vdis_1106	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
Vdis_1107	COG0167	dihydroorotate dehydrogenase activity
Vdis_1112	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Vdis_1116	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
Vdis_1122	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
Vdis_1125	COG0697	spore germination
Vdis_1127	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Vdis_1187	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Vdis_1188	COG0419	ATPase involved in DNA repair
Vdis_1199	COG0459	protein refolding
Vdis_1201	COG0456	acetyltransferase
Vdis_1202	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
Vdis_1203	COG1324	tolerance protein
Vdis_1204	COG0667	Aldo Keto reductase
Vdis_1205	COG0352	thiamine-phosphate diphosphorylase activity
Vdis_1206	COG0668	transmembrane transport
Vdis_1207	COG0012	GTP binding
Vdis_1208	COG0018	arginyl-trna synthetase
Vdis_1210	COG0085	RNA polymerase activity
Vdis_1211	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
Vdis_1212	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
Vdis_1217	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
Vdis_1217	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
Vdis_1224	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Vdis_1225	COG2814	Major facilitator Superfamily
Vdis_1230	COG0667	Aldo Keto reductase
Vdis_1240	COG0425	Belongs to the sulfur carrier protein TusA family
Vdis_1241	COG1254	Belongs to the acylphosphatase family
Vdis_1243	COG0101	tRNA pseudouridine synthase activity
Vdis_1245	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Vdis_1254	COG0149	triose-phosphate isomerase activity
Vdis_1256	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
Vdis_1266	COG0517	IMP dehydrogenase activity
Vdis_1266	COG0516	GMP reductase activity
Vdis_1269	COG0649	NAD binding
Vdis_1269	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Vdis_1269	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Vdis_1270	COG0649	NAD binding
Vdis_1276	COG1960	acyl-CoA dehydrogenase activity
Vdis_1277	COG1960	acyl-CoA dehydrogenase activity
Vdis_1278	COG0318	PFAM AMP-dependent synthetase and ligase
Vdis_1281	COG1250	3-hydroxyacyl-CoA dehydrogenase
Vdis_1284	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
Vdis_1286	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
Vdis_1292	COG2255	four-way junction helicase activity
Vdis_1297	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
Vdis_1307	COG0531	amino acid
Vdis_1311	COG0084	hydrolase, TatD family'
Vdis_1316	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
Vdis_1320	COG1271	oxidase subunit
Vdis_1330	COG1058	Belongs to the CinA family
Vdis_1330	COG1546	Belongs to the CinA family
Vdis_1331	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
Vdis_1333	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Vdis_1339	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
Vdis_1360	COG1331	Highly conserved protein containing a thioredoxin domain
Vdis_1363	COG0114	fumarate hydratase activity
Vdis_1364	COG1741	Belongs to the pirin family
Vdis_1372	COG2897	thiosulfate sulfurtransferase activity
Vdis_1375	COG0312	modulator of DNA gyrase
Vdis_1377	COG0444	Belongs to the ABC transporter superfamily
Vdis_1378	COG4608	Belongs to the ABC transporter superfamily
Vdis_1379	COG0747	negative chemotaxis
Vdis_1380	COG0601	transmembrane transport
Vdis_1383	COG0531	amino acid
Vdis_1387	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
Vdis_1389	COG0113	porphobilinogen synthase activity
Vdis_1390	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Vdis_1393	COG0489	protein tyrosine kinase activity
Vdis_1401	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
Vdis_1404	COG0731	radical SAM domain protein
Vdis_1404	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Vdis_1412	COG0477	Major facilitator Superfamily
Vdis_1414	COG1304	FMN binding
Vdis_1416	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
Vdis_1440	COG1140	nitrate reductase beta subunit
Vdis_1441	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
Vdis_1442	COG2181	nitrate reductase activity
Vdis_1444	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
Vdis_1450	COG3189	MarR family transcriptional regulator
Vdis_1451	COG3256	nitric oxide reductase
Vdis_1454	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Vdis_1454	COG0674	pyruvate-flavodoxin oxidoreductase activity
Vdis_1455	COG1013	pyruvate-flavodoxin oxidoreductase activity
Vdis_1458	COG4948	Mandelate Racemase Muconate Lactonizing
Vdis_1460	COG0604	alcohol dehydrogenase
Vdis_1461	COG2814	Major facilitator Superfamily
Vdis_1463	COG1260	myo-inositol-1-phosphate synthase
Vdis_1465	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
Vdis_1466	COG0315	cyclic pyranopterin monophosphate synthase activity
Vdis_1468	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Vdis_1474	COG0017	Asparaginyl-tRNA synthetase
Vdis_1477	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
Vdis_1483	COG1960	acyl-CoA dehydrogenase activity
Vdis_1491	COG2264	protein methyltransferase activity
Vdis_1497	COG2271	Major facilitator Superfamily
Vdis_1498	COG0584	glycerophosphoryl diester phosphodiesterase
Vdis_1499	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
Vdis_1501	COG2267	carboxylic ester hydrolase activity
Vdis_1508	COG0644	oxidoreductase
Vdis_1509	COG0463	Glycosyl transferase, family 2
Vdis_1511	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
Vdis_1515	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
Vdis_1517	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Vdis_1519	COG1793	dna ligase
Vdis_1520	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
Vdis_1525	COG2813	Specifically methylates the guanine in position
Vdis_1526	COG0308	aminopeptidase N
Vdis_1529	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Vdis_1530	COG1584	GPR1 FUN34 yaaH family protein
Vdis_1532	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
Vdis_1542	COG0275	rRNA processing
Vdis_1546	COG2192	nodulation
Vdis_1562	COG1515	deoxyribonuclease V activity
Vdis_1565	COG0531	amino acid
Vdis_1582	COG2814	Major facilitator Superfamily
Vdis_1585	COG2723	6-phospho-beta-galactosidase activity
Vdis_1591	COG1013	pyruvate-flavodoxin oxidoreductase activity
Vdis_1595	COG1024	Enoyl-CoA hydratase
Vdis_1596	COG0277	FAD linked oxidase domain protein
Vdis_1600	COG2271	Major facilitator Superfamily
Vdis_1605	COG4608	Belongs to the ABC transporter superfamily
Vdis_1606	COG0444	Belongs to the ABC transporter superfamily
Vdis_1608	COG0601	transmembrane transport
Vdis_1610	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
Vdis_1612	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Vdis_1613	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
Vdis_1620	COG1028	Short-chain dehydrogenase reductase Sdr
Vdis_1627	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
Vdis_1630	COG0714	Associated with various cellular activities
Vdis_1633	COG1960	acyl-CoA dehydrogenase activity
Vdis_1634	COG1960	acyl-CoA dehydrogenase activity
Vdis_1635	COG1573	uracil-dna glycosylase
Vdis_1637	COG0180	Tryptophanyl-tRNA synthetase
Vdis_1639	COG1980	fructose-bisphosphate aldolase activity
Vdis_1648	COG4948	Mandelate Racemase Muconate Lactonizing
Vdis_1656	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
Vdis_1659	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
Vdis_1664	COG1335	isochorismatase
Vdis_1675	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
Vdis_1687	COG1401	restriction endodeoxyribonuclease activity
Vdis_1703	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
Vdis_1705	COG0430	RNA-3'-phosphate cyclase activity
Vdis_1710	COG0477	Major facilitator Superfamily
Vdis_1716	COG0142	geranyltranstransferase activity
Vdis_1728	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
Vdis_1732	COG0189	ligase activity
Vdis_1741	COG0006	proline dipeptidase activity
Vdis_1743	COG1078	dGTPase activity
Vdis_1745	COG0180	Tryptophanyl-tRNA synthetase
Vdis_1748	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
Vdis_1749	COG0181	hydroxymethylbilane synthase activity
Vdis_1753	COG0402	S-adenosylhomocysteine deaminase activity
Vdis_1757	COG0039	L-malate dehydrogenase activity
Vdis_1758	COG0009	L-threonylcarbamoyladenylate synthase
Vdis_1759	COG2151	metal-sulfur cluster biosynthetic enzyme
Vdis_1766	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
Vdis_1768	COG0183	Belongs to the thiolase family
Vdis_1773	COG1252	NADH dehydrogenase
Vdis_1775	COG0577	efflux transmembrane transporter activity
Vdis_1775	COG1136	(ABC) transporter
Vdis_1783	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
Vdis_1785	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
Vdis_1786	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
Vdis_1789	COG1051	belongs to the nudix hydrolase family
Vdis_1790	COG1254	Belongs to the acylphosphatase family
Vdis_1796	COG0243	molybdopterin cofactor binding
Vdis_1798	COG1574	metal-dependent hydrolase with the TIM-barrel fold
Vdis_1804	COG2379	hydroxypyruvate reductase
Vdis_1806	COG0531	amino acid
Vdis_1812	COG2835	tetraacyldisaccharide 4'-kinase activity
Vdis_1817	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
Vdis_1821	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
Vdis_1822	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
Vdis_1825	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
Vdis_1836	COG0417	DNA replication proofreading
Vdis_1838	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
Vdis_1839	COG1695	Transcriptional regulator
Vdis_1840	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
Vdis_1844	COG1051	belongs to the nudix hydrolase family
Vdis_1844	COG1056	cytidyltransferase-related domain
Vdis_1845	COG0372	Belongs to the citrate synthase family
Vdis_1850	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
Vdis_1855	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
Vdis_1858	COG0459	protein refolding
Vdis_1868	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Vdis_1869	COG0717	Belongs to the dCTP deaminase family
Vdis_1871	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
Vdis_1875	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
Vdis_1880	COG0175	sulfate reduction
Vdis_1887	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Vdis_1889	COG2079	MmgE PrpD family protein
Vdis_1890	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
Vdis_1893	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
Vdis_1896	COG0693	protein deglycase activity
Vdis_1897	COG0179	Fumarylacetoacetate (FAA) hydrolase
Vdis_1899	COG4555	ABC transporter
Vdis_1903	COG1429	ligase activity, forming nitrogen-metal bonds
Vdis_1904	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
Vdis_1905	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
Vdis_1906	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Vdis_1912	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
Vdis_1923	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
Vdis_1924	COG1250	3-hydroxyacyl-CoA dehydrogenase
Vdis_1926	COG0725	ABC transporter, periplasmic molybdate-binding protein
Vdis_1928	COG1116	anion transmembrane transporter activity
Vdis_1931	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
Vdis_1932	COG0423	glycine-tRNA ligase activity
Vdis_1933	COG0010	Belongs to the arginase family
Vdis_1935	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Vdis_1937	COG0674	pyruvate-flavodoxin oxidoreductase activity
Vdis_1938	COG1013	pyruvate-flavodoxin oxidoreductase activity
Vdis_1943	COG0714	Associated with various cellular activities
Vdis_1948	COG0318	PFAM AMP-dependent synthetase and ligase
Vdis_1949	COG0708	Exodeoxyribonuclease III
Vdis_1954	COG1573	uracil-dna glycosylase
Vdis_1956	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
Vdis_1958	COG1881	PFAM PEBP family protein
Vdis_1959	COG0072	phenylalanine-tRNA ligase activity
Vdis_1969	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
Vdis_1971	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
Vdis_1972	COG2181	nitrate reductase activity
Vdis_1972	COG0247	lactate metabolic process
Vdis_1978	COG0126	phosphoglycerate kinase activity
Vdis_1983	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
Vdis_1984	COG1378	Sugar-specific transcriptional regulator TrmB
Vdis_1985	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
Vdis_1987	COG0674	pyruvate-flavodoxin oxidoreductase activity
Vdis_1992	COG2217	Heavy metal translocating P-type atpase
Vdis_1997	COG0395	ABC-type sugar transport system, permease component
Vdis_1998	COG1175	transmembrane transport
Vdis_2007	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Vdis_2011	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Vdis_2020	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
Vdis_2025	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
Vdis_2026	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Vdis_2026	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
Vdis_2027	COG0538	isocitrate dehydrogenase activity
Vdis_2031	COG0494	nUDIX hydrolase
Vdis_2034	COG1063	alcohol dehydrogenase
Vdis_2035	COG0105	UTP biosynthetic process
Vdis_2036	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
Vdis_2037	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
Vdis_2038	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Vdis_2046	COG4608	Belongs to the ABC transporter superfamily
Vdis_2047	COG0444	Belongs to the ABC transporter superfamily
Vdis_2048	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Vdis_2049	COG0601	transmembrane transport
Vdis_2065	COG2017	converts alpha-aldose to the beta-anomer
Vdis_2084	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
Vdis_2088	COG2046	Belongs to the sulfate adenylyltransferase family
Vdis_2094	COG2181	nitrate reductase activity
Vdis_2099	COG2221	Nitrite and sulphite reductase 4Fe-4S
Vdis_2101	COG2920	part of a sulfur-relay system
Vdis_2105	COG0656	L-ascorbic acid biosynthetic process
Vdis_2113	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Vdis_2113	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
Vdis_2114	COG0442	prolyl-tRNA aminoacylation
Vdis_2115	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
Vdis_2116	COG1085	galactose-1-phosphate uridylyltransferase
Vdis_2120	COG0446	pyridine nucleotide-disulphide oxidoreductase
Vdis_2122	COG2210	Belongs to the sulfur carrier protein TusA family
Vdis_2129	COG0492	ferredoxin-NADP+ reductase activity
Vdis_2130	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
Vdis_2139	COG0247	lactate metabolic process
Vdis_2140	COG0277	FAD linked oxidase domain protein
Vdis_2144	COG2239	Acts as a magnesium transporter
Vdis_2146	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Vdis_2155	COG1007	ATP synthesis coupled electron transport
Vdis_2165	COG0437	4 iron, 4 sulfur cluster binding
Vdis_2166	COG0243	molybdopterin cofactor binding
Vdis_2167	COG3301	Polysulphide reductase, NrfD
Vdis_2176	COG0805	protein transport
Vdis_2179	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Vdis_2181	COG0450	alkyl hydroperoxide reductase
Vdis_2191	COG1024	Enoyl-CoA hydratase
Vdis_2196	COG1940	carbohydrate kinase activity
Vdis_2200	COG0569	domain protein
Vdis_2201	COG0295	cytidine deaminase activity
Vdis_2205	COG1394	ATPase activity, coupled to movement of substances
Vdis_2206	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
Vdis_2211	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
Vdis_2212	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
Vdis_2215	COG1960	acyl-CoA dehydrogenase activity
Vdis_2216	COG0318	PFAM AMP-dependent synthetase and ligase
Vdis_2227	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Vdis_2231	COG0585	pseudouridine synthase activity
Vdis_2235	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
Vdis_2237	COG2860	membrane
Vdis_2239	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Vdis_2241	COG0049	tRNA binding
Vdis_2246	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Vdis_2247	COG2271	Major facilitator Superfamily
Vdis_2249	COG1592	Rubrerythrin
Vdis_2250	COG0735	belongs to the Fur family
Vdis_2251	COG0183	Belongs to the thiolase family
Vdis_2253	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
Vdis_2265	COG0037	tRNA processing
Vdis_2269	COG1110	DNA topoisomerase II activity
Vdis_2276	COG0674	pyruvate-flavodoxin oxidoreductase activity
Vdis_2276	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Vdis_2277	COG1013	pyruvate-flavodoxin oxidoreductase activity
Vdis_2279	COG1233	COG1233 Phytoene dehydrogenase and related
Vdis_2280	COG0247	lactate metabolic process
Vdis_2280	COG2181	nitrate reductase activity
Vdis_2281	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
Vdis_2282	COG2086	electron transfer activity
Vdis_2285	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Vdis_2287	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
Vdis_2288	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
Vdis_2289	COG2255	four-way junction helicase activity
Vdis_2290	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
Vdis_2299	COG4555	ABC transporter
Vdis_2301	COG0017	Asparaginyl-tRNA synthetase
Vdis_2304	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
Vdis_2316	COG0409	Hydrogenase expression formation protein
Vdis_2318	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
Vdis_2320	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
Vdis_2321	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
Vdis_2325	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Vdis_2328	COG1063	alcohol dehydrogenase
Vdis_2333	COG0517	IMP dehydrogenase activity
Vdis_2333	COG0516	GMP reductase activity
Vdis_2336	COG0494	nUDIX hydrolase
Vdis_2337	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
Vdis_2338	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
Vdis_2339	COG1047	Peptidyl-prolyl cis-trans
Vdis_2342	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Vdis_2344	COG0504	CTP synthase activity
Vdis_2355	COG0084	hydrolase, TatD family'
Vdis_2363	COG4948	Mandelate Racemase Muconate Lactonizing
Vdis_2373	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
Vdis_2376	COG3118	belongs to the thioredoxin family
Vdis_2380	COG0501	Belongs to the peptidase M48B family
Vdis_2388	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
Vdis_2389	COG2222	sugar isomerase
Vdis_2391	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
Vdis_2392	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
Vdis_2396	COG2095	MarC family integral membrane protein
Vdis_2402	COG0351	phosphomethylpyrimidine kinase
Vdis_2409	COG2329	Antibiotic biosynthesis monooxygenase
Vdis_2411	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
Vdis_2413	COG4946	Tricorn protease homolog
Vdis_2413	COG0823	Involved in the tonB-independent uptake of proteins
Vdis_2413	COG1506	peptidase
Vdis_2418	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
Vdis_2419	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Vdis_2432	COG1064	alcohol dehydrogenase
Vdis_2435	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
Vdis_2437	COG1335	isochorismatase
Vdis_2439	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
Vdis_2442	COG1028	Short-chain dehydrogenase reductase Sdr
Vdis_2443	COG0471	metal ion transport
Vdis_2443	COG3273	potassium ion transport
Vdis_2447	COG0252	asparaginase activity
Vdis_2449	COG3383	formate dehydrogenase (NAD+) activity
Vdis_2456	COG0528	UMP kinase activity
Vdis_2464	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
Vdis_2470	COG1960	acyl-CoA dehydrogenase activity
Vdis_2475	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
Vdis_2477	COG2855	membrane
Vdis_2483	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
Vdis_2486	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
Vdis_2487	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
Vdis_2488	COG2986	histidine ammonia-lyase
Vdis_2490	COG0531	amino acid
Vdis_2495	COG1228	amidohydrolase
Vdis_2509	COG4948	Mandelate Racemase Muconate Lactonizing
Vdis_2510	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
Vdis_2511	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
Vdis_2520	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
Vdis_2525	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Vdis_2527	COG0517	IMP dehydrogenase activity
Vdis_2527	COG0794	Belongs to the SIS family. GutQ KpsF subfamily