locus-tag	class	description
VMUT_0006	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
VMUT_0007	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
VMUT_0009	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
VMUT_0017	COG1024	Enoyl-CoA hydratase
VMUT_0022	COG2271	Major facilitator Superfamily
VMUT_0023	COG2267	carboxylic ester hydrolase activity
VMUT_0024	COG0318	PFAM AMP-dependent synthetase and ligase
VMUT_0025	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
VMUT_0026	COG1309	transcriptional regulator
VMUT_0027	COG1960	acyl-CoA dehydrogenase activity
VMUT_0028	COG0318	PFAM AMP-dependent synthetase and ligase
VMUT_0032	COG1013	pyruvate-flavodoxin oxidoreductase activity
VMUT_0033	COG0674	pyruvate-flavodoxin oxidoreductase activity
VMUT_0033	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
VMUT_0036	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
VMUT_0037	COG1401	restriction endodeoxyribonuclease activity
VMUT_0041	COG2723	6-phospho-beta-galactosidase activity
VMUT_0056	COG0531	amino acid
VMUT_0059	COG1515	deoxyribonuclease V activity
VMUT_0060	COG0301	tRNA thio-modification
VMUT_0060	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VMUT_0065	COG2192	nodulation
VMUT_0068	COG0275	rRNA processing
VMUT_0080	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
VMUT_0081	COG4608	Belongs to the ABC transporter superfamily
VMUT_0082	COG0444	Belongs to the ABC transporter superfamily
VMUT_0084	COG0601	transmembrane transport
VMUT_0086	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
VMUT_0089	COG0308	aminopeptidase N
VMUT_0090	COG2813	Specifically methylates the guanine in position
VMUT_0092	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
VMUT_0095	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
VMUT_0096	COG1793	dna ligase
VMUT_0098	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VMUT_0100	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
VMUT_0104	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
VMUT_0107	COG0644	oxidoreductase
VMUT_0108	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
VMUT_0109	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
VMUT_0115	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
VMUT_0116	COG0584	glycerophosphoryl diester phosphodiesterase
VMUT_0117	COG2271	Major facilitator Superfamily
VMUT_0119	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
VMUT_0127	COG1960	acyl-CoA dehydrogenase activity
VMUT_0131	COG0058	SHG alpha-glucan phosphorylase activity
VMUT_0133	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
VMUT_0136	COG0017	Asparaginyl-tRNA synthetase
VMUT_0141	COG2271	Major facilitator Superfamily
VMUT_0144	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
VMUT_0146	COG0315	cyclic pyranopterin monophosphate synthase activity
VMUT_0147	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
VMUT_0149	COG1260	myo-inositol-1-phosphate synthase
VMUT_0151	COG1013	pyruvate-flavodoxin oxidoreductase activity
VMUT_0152	COG0674	pyruvate-flavodoxin oxidoreductase activity
VMUT_0152	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
VMUT_0175	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
VMUT_0177	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
VMUT_0181	COG0189	ligase activity
VMUT_0189	COG0006	proline dipeptidase activity
VMUT_0190	COG1078	dGTPase activity
VMUT_0192	COG0180	Tryptophanyl-tRNA synthetase
VMUT_0195	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
VMUT_0196	COG0181	hydroxymethylbilane synthase activity
VMUT_0200	COG0402	S-adenosylhomocysteine deaminase activity
VMUT_0204	COG0039	L-malate dehydrogenase activity
VMUT_0205	COG0009	L-threonylcarbamoyladenylate synthase
VMUT_0206	COG2151	metal-sulfur cluster biosynthetic enzyme
VMUT_0213	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
VMUT_0215	COG0183	Belongs to the thiolase family
VMUT_0221	COG0577	efflux transmembrane transporter activity
VMUT_0222	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
VMUT_0229	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
VMUT_0230	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
VMUT_0234	COG1254	Belongs to the acylphosphatase family
VMUT_0240	COG0243	molybdopterin cofactor binding
VMUT_0242	COG1574	metal-dependent hydrolase with the TIM-barrel fold
VMUT_0246	COG2379	hydroxypyruvate reductase
VMUT_0262	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
VMUT_0263	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
VMUT_0266	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
VMUT_0274	COG0047	phosphoribosylformylglycinamidine synthase activity
VMUT_0275	COG0417	DNA replication proofreading
VMUT_0277	COG1213	nucleotidyl transferase
VMUT_0277	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
VMUT_0278	COG1695	Transcriptional regulator
VMUT_0279	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
VMUT_0280	COG0426	domain, Protein
VMUT_0281	COG1056	cytidyltransferase-related domain
VMUT_0281	COG1051	belongs to the nudix hydrolase family
VMUT_0282	COG0372	Belongs to the citrate synthase family
VMUT_0287	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
VMUT_0292	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
VMUT_0295	COG0459	protein refolding
VMUT_0297	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
VMUT_0305	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VMUT_0305	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VMUT_0306	COG0717	Belongs to the dCTP deaminase family
VMUT_0309	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
VMUT_0314	COG0175	sulfate reduction
VMUT_0316	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
VMUT_0317	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
VMUT_0318	COG2079	MmgE PrpD family protein
VMUT_0319	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
VMUT_0323	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
VMUT_0326	COG1070	Carbohydrate kinase
VMUT_0327	COG0076	glutamate decarboxylase activity
VMUT_0330	COG4555	ABC transporter
VMUT_0335	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
VMUT_0336	COG1250	3-hydroxyacyl-CoA dehydrogenase
VMUT_0338	COG0725	ABC transporter, periplasmic molybdate-binding protein
VMUT_0343	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
VMUT_0344	COG0423	glycine-tRNA ligase activity
VMUT_0345	COG0010	Belongs to the arginase family
VMUT_0347	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
VMUT_0349	COG0674	pyruvate-flavodoxin oxidoreductase activity
VMUT_0350	COG1013	pyruvate-flavodoxin oxidoreductase activity
VMUT_0357	COG0714	Associated with various cellular activities
VMUT_0362	COG0318	PFAM AMP-dependent synthetase and ligase
VMUT_0363	COG0708	Exodeoxyribonuclease III
VMUT_0367	COG1573	uracil-dna glycosylase
VMUT_0369	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
VMUT_0371	COG1881	PFAM PEBP family protein
VMUT_0372	COG0072	phenylalanine-tRNA ligase activity
VMUT_0381	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
VMUT_0382	COG2086	electron transfer activity
VMUT_0383	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
VMUT_0384	COG2181	nitrate reductase activity
VMUT_0384	COG0247	lactate metabolic process
VMUT_0385	COG2815	serine threonine protein kinase
VMUT_0385	COG0515	serine threonine protein kinase
VMUT_0390	COG0126	phosphoglycerate kinase activity
VMUT_0394	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
VMUT_0396	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
VMUT_0398	COG0674	pyruvate-flavodoxin oxidoreductase activity
VMUT_0406	COG1846	Transcriptional regulator
VMUT_0409	COG0395	ABC-type sugar transport system, permease component
VMUT_0410	COG1175	transmembrane transport
VMUT_0412	COG0366	Alpha amylase catalytic
VMUT_0414	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
VMUT_0419	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
VMUT_0420	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
VMUT_0428	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
VMUT_0430	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
VMUT_0432	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
VMUT_0433	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
VMUT_0433	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
VMUT_0434	COG0538	isocitrate dehydrogenase activity
VMUT_0437	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
VMUT_0438	COG0494	nUDIX hydrolase
VMUT_0441	COG1063	alcohol dehydrogenase
VMUT_0443	COG0105	UTP biosynthetic process
VMUT_0444	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
VMUT_0445	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
VMUT_0446	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
VMUT_0454	COG4608	Belongs to the ABC transporter superfamily
VMUT_0455	COG0444	Belongs to the ABC transporter superfamily
VMUT_0456	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VMUT_0457	COG0601	transmembrane transport
VMUT_0483	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
VMUT_0488	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
VMUT_0492	COG2046	Belongs to the sulfate adenylyltransferase family
VMUT_0502	COG2221	Nitrite and sulphite reductase 4Fe-4S
VMUT_0504	COG2920	part of a sulfur-relay system
VMUT_0508	COG0656	L-ascorbic acid biosynthetic process
VMUT_0516	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
VMUT_0516	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
VMUT_0519	COG1085	galactose-1-phosphate uridylyltransferase
VMUT_0523	COG0446	pyridine nucleotide-disulphide oxidoreductase
VMUT_0525	COG2210	Belongs to the sulfur carrier protein TusA family
VMUT_0528	COG0492	ferredoxin-NADP+ reductase activity
VMUT_0529	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
VMUT_0530	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
VMUT_0536	COG0129	dihydroxy-acid dehydratase activity
VMUT_0537	COG0473	3-isopropylmalate dehydrogenase activity
VMUT_0538	COG1028	Short-chain dehydrogenase reductase Sdr
VMUT_0539	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
VMUT_0542	COG0247	lactate metabolic process
VMUT_0543	COG0277	FAD linked oxidase domain protein
VMUT_0548	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
VMUT_0557	COG1007	ATP synthesis coupled electron transport
VMUT_0560	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
VMUT_0567	COG0437	4 iron, 4 sulfur cluster binding
VMUT_0571	COG0805	protein transport
VMUT_0574	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
VMUT_0576	COG0450	alkyl hydroperoxide reductase
VMUT_0585	COG1024	Enoyl-CoA hydratase
VMUT_0586	COG2414	aldehyde ferredoxin oxidoreductase
VMUT_0590	COG1940	carbohydrate kinase activity
VMUT_0592	COG0589	response to stress
VMUT_0595	COG0295	cytidine deaminase activity
VMUT_0600	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
VMUT_0605	COG1012	belongs to the aldehyde dehydrogenase family
VMUT_0606	COG0516	GMP reductase activity
VMUT_0606	COG0517	IMP dehydrogenase activity
VMUT_0610	COG1063	alcohol dehydrogenase
VMUT_0612	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
VMUT_0613	COG2271	Major facilitator Superfamily
VMUT_0615	COG0017	Asparaginyl-tRNA synthetase
VMUT_0617	COG4555	ABC transporter
VMUT_0624	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
VMUT_0625	COG2255	four-way junction helicase activity
VMUT_0626	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
VMUT_0627	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
VMUT_0629	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
VMUT_0632	COG2086	electron transfer activity
VMUT_0633	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
VMUT_0634	COG0247	lactate metabolic process
VMUT_0634	COG2181	nitrate reductase activity
VMUT_0635	COG1233	COG1233 Phytoene dehydrogenase and related
VMUT_0637	COG1013	pyruvate-flavodoxin oxidoreductase activity
VMUT_0638	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
VMUT_0638	COG0674	pyruvate-flavodoxin oxidoreductase activity
VMUT_0643	COG1110	DNA topoisomerase II activity
VMUT_0646	COG0183	Belongs to the thiolase family
VMUT_0648	COG1592	Rubrerythrin
VMUT_0650	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
VMUT_0653	COG0049	tRNA binding
VMUT_0655	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
VMUT_0657	COG2860	membrane
VMUT_0658	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
VMUT_0662	COG0585	pseudouridine synthase activity
VMUT_0666	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
VMUT_0679	COG0318	PFAM AMP-dependent synthetase and ligase
VMUT_0680	COG1960	acyl-CoA dehydrogenase activity
VMUT_0682	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
VMUT_0683	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
VMUT_0683	COG3266	domain, Protein
VMUT_0688	COG0494	nUDIX hydrolase
VMUT_0689	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
VMUT_0690	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
VMUT_0691	COG1047	Peptidyl-prolyl cis-trans
VMUT_0694	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
VMUT_0696	COG0504	CTP synthase activity
VMUT_0707	COG0084	hydrolase, TatD family'
VMUT_0713	COG0189	ligase activity
VMUT_0715	COG4948	Mandelate Racemase Muconate Lactonizing
VMUT_0723	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
VMUT_0724	COG3118	belongs to the thioredoxin family
VMUT_0728	COG0501	Belongs to the peptidase M48B family
VMUT_0735	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
VMUT_0737	COG2222	sugar isomerase
VMUT_0738	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
VMUT_0739	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
VMUT_0743	COG2095	MarC family integral membrane protein
VMUT_0747	COG0351	phosphomethylpyrimidine kinase
VMUT_0755	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
VMUT_0756	COG0823	Involved in the tonB-independent uptake of proteins
VMUT_0756	COG1506	peptidase
VMUT_0756	COG4946	Tricorn protease homolog
VMUT_0760	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
VMUT_0761	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
VMUT_0775	COG1228	amidohydrolase
VMUT_0776	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
VMUT_0781	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
VMUT_0784	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
VMUT_0788	COG2855	membrane
VMUT_0791	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
VMUT_0797	COG1960	acyl-CoA dehydrogenase activity
VMUT_0803	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
VMUT_0804	COG1028	Short-chain dehydrogenase reductase Sdr
VMUT_0805	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
VMUT_0808	COG1234	tRNA 3'-trailer cleavage
VMUT_0809	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
VMUT_0815	COG3383	formate dehydrogenase (NAD+) activity
VMUT_0816	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
VMUT_0819	COG2002	toxin-antitoxin pair type II binding
VMUT_0820	COG0252	asparaginase activity
VMUT_0825	COG3273	potassium ion transport
VMUT_0825	COG0471	metal ion transport
VMUT_0826	COG1028	Short-chain dehydrogenase reductase Sdr
VMUT_0829	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
VMUT_0830	COG1335	isochorismatase
VMUT_0832	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
VMUT_0842	COG1575	Belongs to the MenA family. Type 1 subfamily
VMUT_0856	COG4948	Mandelate Racemase Muconate Lactonizing
VMUT_0857	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
VMUT_0858	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
VMUT_0865	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
VMUT_0870	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
VMUT_0872	COG0516	GMP reductase activity
VMUT_0872	COG0517	IMP dehydrogenase activity
VMUT_0883	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
VMUT_0893	COG0463	Glycosyl transferase, family 2
VMUT_0894	COG0116	Belongs to the methyltransferase superfamily
VMUT_0894	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
VMUT_0896	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
VMUT_0903	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
VMUT_0904	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
VMUT_0906	COG0081	regulation of translation
VMUT_0910	COG0457	Tetratricopeptide repeat
VMUT_0910	COG0552	protein localization to endoplasmic reticulum
VMUT_0914	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
VMUT_0918	COG0405	Gamma-glutamyltransferase
VMUT_0920	COG4139	cobalamin transport
VMUT_0921	COG1120	ATPase activity
VMUT_0922	COG2414	aldehyde ferredoxin oxidoreductase
VMUT_0924	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
VMUT_0924	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
VMUT_0931	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
VMUT_0933	COG0163	prenyltransferase activity
VMUT_0934	COG0037	tRNA processing
VMUT_0935	COG0525	valine-tRNA ligase activity
VMUT_0938	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
VMUT_0945	COG0531	amino acid
VMUT_0946	COG0531	amino acid
VMUT_0960	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
VMUT_0963	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
VMUT_0965	COG0200	Binds to the 23S rRNA
VMUT_0972	COG1028	Short-chain dehydrogenase reductase Sdr
VMUT_0978	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
VMUT_0979	COG1363	Peptidase, m42
VMUT_0980	COG2252	PERMEase
VMUT_1035	COG0714	Associated with various cellular activities
VMUT_1051	COG1216	Glycosyl transferase, family 2
VMUT_1054	COG1215	transferase activity, transferring glycosyl groups
VMUT_1070	COG3119	arylsulfatase activity
VMUT_1076	COG1215	transferase activity, transferring glycosyl groups
VMUT_1079	COG0463	Glycosyl transferase, family 2
VMUT_1086	COG0275	rRNA processing
VMUT_1090	COG0438	transferase activity, transferring glycosyl groups
VMUT_1092	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
VMUT_1093	COG0297	glycogen (starch) synthase activity
VMUT_1094	COG0463	Glycosyl transferase, family 2
VMUT_1095	COG0297	glycogen (starch) synthase activity
VMUT_1110	COG0714	Associated with various cellular activities
VMUT_1112	COG0463	Glycosyl transferase, family 2
VMUT_1114	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
VMUT_1131	COG1032	radical SAM domain protein
VMUT_1133	COG0644	oxidoreductase
VMUT_1135	COG2086	electron transfer activity
VMUT_1136	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
VMUT_1137	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
VMUT_1150	COG4948	Mandelate Racemase Muconate Lactonizing
VMUT_1151	COG2721	sulfolactate sulfo-lyase activity
VMUT_1153	COG1802	Transcriptional regulator
VMUT_1154	COG0477	Major facilitator Superfamily
VMUT_1156	COG1574	metal-dependent hydrolase with the TIM-barrel fold
VMUT_1158	COG0477	Major facilitator Superfamily
VMUT_1161	COG0508	dehydrogenase complex catalyzes the overall conversion of
VMUT_1169	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
VMUT_1170	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
VMUT_1178	COG1012	belongs to the aldehyde dehydrogenase family
VMUT_1179	COG2226	methyltransferase
VMUT_1197	COG1144	Oxidoreductase
VMUT_1198	COG0674	pyruvate-flavodoxin oxidoreductase activity
VMUT_1199	COG1013	pyruvate-flavodoxin oxidoreductase activity
VMUT_1201	COG0277	FAD linked oxidase domain protein
VMUT_1202	COG0277	FAD linked oxidase domain protein
VMUT_1204	COG1620	l-lactate permease
VMUT_1205	COG0083	homoserine kinase activity
VMUT_1213	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
VMUT_1225	COG0124	histidyl-tRNA synthetase
VMUT_1232	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
VMUT_1234	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
VMUT_1234	COG0674	pyruvate-flavodoxin oxidoreductase activity
VMUT_1235	COG1063	alcohol dehydrogenase
VMUT_1238	COG4948	Mandelate Racemase Muconate Lactonizing
VMUT_1241	COG1312	Catalyzes the dehydration of D-mannonate
VMUT_1242	COG2414	aldehyde ferredoxin oxidoreductase
VMUT_1243	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
VMUT_1245	COG2814	Major facilitator Superfamily
VMUT_1247	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
VMUT_1249	COG1129	ABC transporter
VMUT_1251	COG1653	transport
VMUT_1253	COG1058	Belongs to the CinA family
VMUT_1253	COG1546	Belongs to the CinA family
VMUT_1254	COG2084	Dehydrogenase
VMUT_1255	COG2721	sulfolactate sulfo-lyase activity
VMUT_1260	COG3842	ATPase activity
VMUT_1263	COG1830	Aldolase
VMUT_1266	COG0215	cysteine-tRNA ligase activity
VMUT_1268	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
VMUT_1271	COG0255	Belongs to the universal ribosomal protein uL29 family
VMUT_1272	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
VMUT_1279	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
VMUT_1280	COG0069	glutamate synthase activity
VMUT_1281	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
VMUT_1282	COG0318	PFAM AMP-dependent synthetase and ligase
VMUT_1283	COG0303	'Molybdopterin
VMUT_1293	COG1881	PFAM PEBP family protein
VMUT_1294	COG0129	dihydroxy-acid dehydratase activity
VMUT_1296	COG0302	gtp cyclohydrolase
VMUT_1301	COG0598	Magnesium transport protein CorA
VMUT_1303	COG1529	Aldehyde oxidase and xanthine dehydrogenase
VMUT_1305	COG2271	Major facilitator Superfamily
VMUT_1309	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
VMUT_1310	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
VMUT_1311	COG0535	radical SAM domain protein
VMUT_1312	COG0535	radical SAM domain protein
VMUT_1317	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
VMUT_1318	COG0574	Belongs to the PEP-utilizing enzyme family
VMUT_1318	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
VMUT_1323	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
VMUT_1325	COG1867	N(2),N(2)-dimethylguanosine tRNA methyltransferase
VMUT_1336	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
VMUT_1339	COG1136	(ABC) transporter
VMUT_1347	COG2814	Major facilitator Superfamily
VMUT_1348	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
VMUT_1352	COG0019	diaminopimelate decarboxylase activity
VMUT_1354	COG1804	L-carnitine dehydratase bile acid-inducible protein F
VMUT_1357	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
VMUT_1358	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
VMUT_1360	COG0277	FAD linked oxidase domain protein
VMUT_1361	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
VMUT_1363	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
VMUT_1369	COG1960	acyl-CoA dehydrogenase activity
VMUT_1372	COG0028	Belongs to the TPP enzyme family
VMUT_1373	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
VMUT_1375	COG1250	3-hydroxyacyl-CoA dehydrogenase
VMUT_1376	COG0183	Belongs to the thiolase family
VMUT_1378	COG1024	Enoyl-CoA hydratase
VMUT_1381	COG0318	PFAM AMP-dependent synthetase and ligase
VMUT_1387	COG0483	inositol monophosphate 1-phosphatase activity
VMUT_1405	COG1618	nucleotide phosphatase activity, acting on free nucleotides
VMUT_1409	COG2226	methyltransferase
VMUT_1411	COG0719	Fe-S assembly protein
VMUT_1412	COG0719	Fe-S assembly protein
VMUT_1413	COG0396	ATPase activity
VMUT_1414	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
VMUT_1417	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
VMUT_1417	COG0512	Glutamine amidotransferase of anthranilate synthase
VMUT_1418	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
VMUT_1419	COG0135	phosphoribosylanthranilate isomerase activity
VMUT_1420	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
VMUT_1421	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
VMUT_1422	COG0159	tryptophan synthase activity
VMUT_1426	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
VMUT_1429	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
VMUT_1431	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
VMUT_1432	COG1605	Chorismate mutase
VMUT_1432	COG0077	Prephenate dehydratase
VMUT_1434	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
VMUT_1437	COG0519	Catalyzes the synthesis of GMP from XMP
VMUT_1437	COG0518	GMP synthase (glutamine-hydrolyzing) activity
VMUT_1438	COG0518	GMP synthase (glutamine-hydrolyzing) activity
VMUT_1438	COG0519	Catalyzes the synthesis of GMP from XMP
VMUT_1450	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
VMUT_1450	COG0517	IMP dehydrogenase activity
VMUT_1451	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
VMUT_1453	COG0420	3'-5' exonuclease activity
VMUT_1456	COG0045	succinate-CoA ligase (ADP-forming) activity
VMUT_1456	COG1042	CoA-binding domain protein
VMUT_1456	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VMUT_1463	COG1131	(ABC) transporter
VMUT_1465	COG1185	polyribonucleotide nucleotidyltransferase activity
VMUT_1467	COG0023	Translation Initiation Factor
VMUT_1469	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
VMUT_1470	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
VMUT_1498	COG1201	RNA secondary structure unwinding
VMUT_1504	COG1192	Involved in chromosome partitioning
VMUT_1507	COG2154	pterin-4-alpha-carbinolamine dehydratase
VMUT_1512	COG0477	Major facilitator Superfamily
VMUT_1517	COG0077	Prephenate dehydratase
VMUT_1518	COG0473	3-isopropylmalate dehydrogenase activity
VMUT_1520	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
VMUT_1521	COG0028	Belongs to the TPP enzyme family
VMUT_1523	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
VMUT_1524	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
VMUT_1526	COG0066	3-isopropylmalate dehydratase activity
VMUT_1527	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
VMUT_1528	COG0527	aspartate kinase activity
VMUT_1529	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
VMUT_1532	COG0477	Major facilitator Superfamily
VMUT_1533	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
VMUT_1535	COG0189	ligase activity
VMUT_1536	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
VMUT_1538	COG0189	ligase activity
VMUT_1540	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
VMUT_1542	COG0505	Belongs to the CarA family
VMUT_1543	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
VMUT_1544	COG0165	Argininosuccinate lyase
VMUT_1547	COG0137	argininosuccinate synthase activity
VMUT_1548	COG0612	Peptidase, M16
VMUT_1550	COG0051	transcription antitermination factor activity, RNA binding
VMUT_1551	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
VMUT_1554	COG0477	Major facilitator Superfamily
VMUT_1570	COG0174	glutamine synthetase
VMUT_1572	COG3118	belongs to the thioredoxin family
VMUT_1576	COG1102	Psort location Cytoplasmic, score
VMUT_1579	COG1355	regulation of microtubule-based process
VMUT_1580	COG0052	Belongs to the universal ribosomal protein uS2 family
VMUT_1581	COG0148	phosphopyruvate hydratase activity
VMUT_1584	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
VMUT_1584	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
VMUT_1588	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
VMUT_1596	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
VMUT_1598	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
VMUT_1599	COG1648	precorrin-2 dehydrogenase activity
VMUT_1599	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
VMUT_1601	COG1024	Enoyl-CoA hydratase
VMUT_1607	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
VMUT_1616	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
VMUT_1623	COG1058	Belongs to the CinA family
VMUT_1623	COG1546	Belongs to the CinA family
VMUT_1642	COG1121	(ABC) transporter
VMUT_1646	COG2226	methyltransferase
VMUT_1650	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
VMUT_1656	COG0546	phosphoglycolate phosphatase activity
VMUT_1659	COG2078	PFAM AMMECR1 domain protein
VMUT_1664	COG0071	Belongs to the small heat shock protein (HSP20) family
VMUT_1666	COG2264	protein methyltransferase activity
VMUT_1675	COG0644	oxidoreductase
VMUT_1677	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
VMUT_1679	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
VMUT_1680	COG1185	polyribonucleotide nucleotidyltransferase activity
VMUT_1681	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
VMUT_1690	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
VMUT_1691	COG1607	acyl-coa hydrolase
VMUT_1695	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
VMUT_1723	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
VMUT_1724	COG0746	molybdenum cofactor guanylyltransferase activity
VMUT_1734	COG0517	IMP dehydrogenase activity
VMUT_1734	COG0516	GMP reductase activity
VMUT_1737	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
VMUT_1739	COG0675	Transposase, IS605 OrfB family
VMUT_1751	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
VMUT_1760	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
VMUT_1762	COG0200	Binds to the 23S rRNA
VMUT_1771	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
VMUT_1774	COG1201	RNA secondary structure unwinding
VMUT_1780	COG0281	malic enzyme
VMUT_1782	COG1522	sequence-specific DNA binding
VMUT_1783	COG0417	DNA replication proofreading
VMUT_1786	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
VMUT_1787	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
VMUT_1787	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
VMUT_1788	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
VMUT_1791	COG0109	protoheme IX farnesyltransferase activity
VMUT_1812	COG1444	tRNA N-acetyltransferase activity
VMUT_1814	COG0651	ATP synthesis coupled electron transport
VMUT_1816	COG1139	Iron-sulfur cluster binding protein
VMUT_1818	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
VMUT_1829	COG2095	MarC family integral membrane protein
VMUT_1830	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
VMUT_1831	COG0017	Asparaginyl-tRNA synthetase
VMUT_1836	COG0531	amino acid
VMUT_1837	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VMUT_1838	COG0318	PFAM AMP-dependent synthetase and ligase
VMUT_1839	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
VMUT_1848	COG0442	prolyl-tRNA aminoacylation
VMUT_1852	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VMUT_1852	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VMUT_1853	COG0612	Peptidase, M16
VMUT_1854	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
VMUT_1862	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
VMUT_1865	COG0433	COG0433 Predicted ATPase
VMUT_1867	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
VMUT_1868	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
VMUT_1869	COG1702	phosphate starvation-inducible protein PhoH
VMUT_1871	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
VMUT_1879	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
VMUT_1881	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
VMUT_1899	COG1013	pyruvate-flavodoxin oxidoreductase activity
VMUT_1930	COG0602	queuosine metabolic process
VMUT_1931	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
VMUT_1933	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
VMUT_1934	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
VMUT_1935	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
VMUT_1936	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
VMUT_1937	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
VMUT_1938	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
VMUT_1939	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
VMUT_1940	COG0151	Belongs to the GarS family
VMUT_1941	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
VMUT_1942	COG0047	phosphoribosylformylglycinamidine synthase activity
VMUT_1946	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
VMUT_1959	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
VMUT_1961	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
VMUT_1962	COG0045	succinate-CoA ligase (ADP-forming) activity
VMUT_1966	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
VMUT_1967	COG3842	ATPase activity
VMUT_1969	COG0540	Belongs to the ATCase OTCase family
VMUT_1970	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
VMUT_1971	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
VMUT_1971	COG0284	orotidine-5'-phosphate decarboxylase activity
VMUT_1972	COG0167	dihydroorotate dehydrogenase activity
VMUT_1977	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
VMUT_1981	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
VMUT_1986	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
VMUT_1989	COG4221	oxidoreductase activity
VMUT_1995	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
VMUT_2007	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
VMUT_2013	COG0697	spore germination
VMUT_2035	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
VMUT_2036	COG0419	ATPase involved in DNA repair
VMUT_2047	COG0459	protein refolding
VMUT_2049	COG0456	acetyltransferase
VMUT_2050	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
VMUT_2051	COG1324	tolerance protein
VMUT_2052	COG0667	Aldo Keto reductase
VMUT_2053	COG0352	thiamine-phosphate diphosphorylase activity
VMUT_2054	COG0668	transmembrane transport
VMUT_2055	COG0012	GTP binding
VMUT_2056	COG0018	arginyl-trna synthetase
VMUT_2058	COG0085	RNA polymerase activity
VMUT_2059	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
VMUT_2060	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
VMUT_2061	COG1358	cellular component organization or biogenesis
VMUT_2065	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
VMUT_2065	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
VMUT_2071	COG2814	Major facilitator Superfamily
VMUT_2074	COG0667	Aldo Keto reductase
VMUT_2076	COG0425	Belongs to the sulfur carrier protein TusA family
VMUT_2079	COG0101	tRNA pseudouridine synthase activity
VMUT_2081	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
VMUT_2083	COG1122	ATPase activity
VMUT_2084	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
VMUT_2093	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
VMUT_2097	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
VMUT_2101	COG0517	IMP dehydrogenase activity
VMUT_2101	COG0516	GMP reductase activity
VMUT_2104	COG0649	NAD binding
VMUT_2104	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
VMUT_2104	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
VMUT_2105	COG0649	NAD binding
VMUT_2112	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
VMUT_2119	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
VMUT_2124	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
VMUT_2134	COG0531	amino acid
VMUT_2139	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
VMUT_2142	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
VMUT_2146	COG1271	oxidase subunit
VMUT_2147	COG0446	pyridine nucleotide-disulphide oxidoreductase
VMUT_2156	COG1546	Belongs to the CinA family
VMUT_2156	COG1058	Belongs to the CinA family
VMUT_2159	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
VMUT_2186	COG0312	modulator of DNA gyrase
VMUT_2188	COG0444	Belongs to the ABC transporter superfamily
VMUT_2189	COG4608	Belongs to the ABC transporter superfamily
VMUT_2190	COG0747	negative chemotaxis
VMUT_2191	COG0601	transmembrane transport
VMUT_2198	COG0113	porphobilinogen synthase activity
VMUT_2199	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
VMUT_2202	COG0489	protein tyrosine kinase activity
VMUT_2213	COG0731	radical SAM domain protein
VMUT_2213	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
VMUT_2218	COG1234	tRNA 3'-trailer cleavage
VMUT_2221	COG0477	Major facilitator Superfamily
VMUT_2223	COG1304	FMN binding
VMUT_2225	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
VMUT_2234	COG1801	Protein of unknown function DUF72
VMUT_2247	COG0477	Major facilitator Superfamily
VMUT_2251	COG2366	antibiotic biosynthetic process
VMUT_2252	COG0318	PFAM AMP-dependent synthetase and ligase
VMUT_2254	COG0318	PFAM AMP-dependent synthetase and ligase
VMUT_2259	COG1028	Short-chain dehydrogenase reductase Sdr
VMUT_2260	COG1028	Short-chain dehydrogenase reductase Sdr
VMUT_2263	COG2816	NAD+ diphosphatase activity
VMUT_2264	COG0477	Major facilitator Superfamily
VMUT_2265	COG0430	RNA-3'-phosphate cyclase activity
VMUT_2267	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
VMUT_2275	COG0531	amino acid
VMUT_2279	COG1131	(ABC) transporter
VMUT_2286	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
VMUT_2290	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
VMUT_2296	COG1335	isochorismatase
VMUT_2300	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
VMUT_2301	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
VMUT_2304	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
VMUT_2313	COG4948	Mandelate Racemase Muconate Lactonizing
VMUT_2322	COG1980	fructose-bisphosphate aldolase activity
VMUT_2326	COG1573	uracil-dna glycosylase
VMUT_2327	COG1960	acyl-CoA dehydrogenase activity
VMUT_2328	COG1960	acyl-CoA dehydrogenase activity
VMUT_2331	COG0714	Associated with various cellular activities
VMUT_2334	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
VMUT_2341	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
VMUT_2342	COG1053	succinate dehydrogenase
VMUT_2344	COG0425	Belongs to the sulfur carrier protein TusA family