locus-tag	class	description
Vsou_00050	COG0463	Glycosyl transferase, family 2
Vsou_00060	COG0116	Belongs to the methyltransferase superfamily
Vsou_00060	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
Vsou_00080	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
Vsou_00140	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
Vsou_00150	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Vsou_00250	COG0457	Tetratricopeptide repeat
Vsou_00250	COG0552	protein localization to endoplasmic reticulum
Vsou_00290	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
Vsou_00330	COG0405	Gamma-glutamyltransferase
Vsou_00350	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Vsou_00360	COG1120	ATPase activity
Vsou_00380	COG2414	aldehyde ferredoxin oxidoreductase
Vsou_00400	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
Vsou_00400	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
Vsou_00410	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
Vsou_00410	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
Vsou_00470	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
Vsou_00500	COG0037	tRNA processing
Vsou_00520	COG0525	valine-tRNA ligase activity
Vsou_00550	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Vsou_00650	COG0402	S-adenosylhomocysteine deaminase activity
Vsou_00670	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
Vsou_00680	COG0157	Belongs to the NadC ModD family
Vsou_00690	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
Vsou_00730	COG1454	alcohol dehydrogenase
Vsou_00740	COG0022	dehydrogenase e1 component
Vsou_00760	COG0022	dehydrogenase e1 component
Vsou_00770	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
Vsou_00790	COG0095	Lipoate-protein ligase
Vsou_00810	COG0508	dehydrogenase complex catalyzes the overall conversion of
Vsou_00860	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
Vsou_00870	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
Vsou_00880	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Vsou_00890	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
Vsou_00900	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
Vsou_00910	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
Vsou_00920	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
Vsou_00930	COG0151	Belongs to the GarS family
Vsou_00950	COG0477	Major facilitator Superfamily
Vsou_00960	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
Vsou_00970	COG0047	phosphoribosylformylglycinamidine synthase activity
Vsou_01080	COG0017	Asparaginyl-tRNA synthetase
Vsou_01130	COG0778	Nitroreductase
Vsou_01130	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
Vsou_01200	COG4608	Belongs to the ABC transporter superfamily
Vsou_01210	COG0444	Belongs to the ABC transporter superfamily
Vsou_01220	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Vsou_01230	COG0601	transmembrane transport
Vsou_01240	COG4166	transmembrane transport
Vsou_01270	COG0596	Alpha beta hydrolase
Vsou_01330	COG0430	RNA-3'-phosphate cyclase activity
Vsou_01370	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
Vsou_01450	COG2045	Belongs to the ComB family
Vsou_01480	COG5564	TIM-barrel signal transduction protein
Vsou_01620	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Vsou_01700	COG1028	Short-chain dehydrogenase reductase Sdr
Vsou_01770	COG0412	Dienelactone hydrolase
Vsou_01780	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
Vsou_01820	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Vsou_01910	COG1205	dead DEAH box helicase
Vsou_01910	COG1111	helicase
Vsou_01930	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
Vsou_01940	COG2814	Major facilitator Superfamily
Vsou_01950	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
Vsou_01980	COG1012	belongs to the aldehyde dehydrogenase family
Vsou_02030	COG4948	Mandelate Racemase Muconate Lactonizing
Vsou_02140	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
Vsou_02180	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
Vsou_02190	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
Vsou_02220	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
Vsou_02370	COG1492	cobalamin metabolic process
Vsou_02390	COG0417	DNA replication proofreading
Vsou_02410	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
Vsou_02410	COG1213	nucleotidyl transferase
Vsou_02430	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
Vsou_02440	COG0426	domain, Protein
Vsou_02470	COG1056	cytidyltransferase-related domain
Vsou_02470	COG1051	belongs to the nudix hydrolase family
Vsou_02480	COG0372	Belongs to the citrate synthase family
Vsou_02530	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
Vsou_02580	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
Vsou_02610	COG0459	protein refolding
Vsou_02630	COG3854	ATPases associated with a variety of cellular activities
Vsou_02670	COG0343	queuine tRNA-ribosyltransferase activity
Vsou_02710	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Vsou_02720	COG0717	Belongs to the dCTP deaminase family
Vsou_02740	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
Vsou_02770	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
Vsou_02820	COG0175	sulfate reduction
Vsou_02890	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Vsou_02900	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
Vsou_02910	COG2079	MmgE PrpD family protein
Vsou_02950	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
Vsou_02970	COG0456	acetyltransferase
Vsou_03090	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Vsou_03210	COG0395	ABC-type sugar transport system, permease component
Vsou_03270	COG2217	Heavy metal translocating P-type atpase
Vsou_03320	COG0674	pyruvate-flavodoxin oxidoreductase activity
Vsou_03340	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
Vsou_03350	COG1378	Sugar-specific transcriptional regulator TrmB
Vsou_03360	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
Vsou_03410	COG0126	phosphoglycerate kinase activity
Vsou_03460	COG0515	serine threonine protein kinase
Vsou_03460	COG2815	serine threonine protein kinase
Vsou_03470	COG0247	lactate metabolic process
Vsou_03470	COG2181	nitrate reductase activity
Vsou_03480	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
Vsou_03490	COG2086	electron transfer activity
Vsou_03660	COG0714	Associated with various cellular activities
Vsou_03700	COG0072	phenylalanine-tRNA ligase activity
Vsou_03710	COG1881	PFAM PEBP family protein
Vsou_03730	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
Vsou_03750	COG1573	uracil-dna glycosylase
Vsou_03790	COG0708	Exodeoxyribonuclease III
Vsou_03800	COG0318	PFAM AMP-dependent synthetase and ligase
Vsou_03850	COG0714	Associated with various cellular activities
Vsou_03890	COG2271	Major facilitator Superfamily
Vsou_04000	COG1574	metal-dependent hydrolase with the TIM-barrel fold
Vsou_04020	COG0243	molybdopterin cofactor binding
Vsou_04080	COG1254	Belongs to the acylphosphatase family
Vsou_04120	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
Vsou_04130	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
Vsou_04200	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Vsou_04210	COG0577	efflux transmembrane transporter activity
Vsou_04220	COG1252	NADH dehydrogenase
Vsou_04240	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
Vsou_04270	COG0183	Belongs to the thiolase family
Vsou_04290	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
Vsou_04360	COG2151	metal-sulfur cluster biosynthetic enzyme
Vsou_04370	COG0009	L-threonylcarbamoyladenylate synthase
Vsou_04380	COG0039	L-malate dehydrogenase activity
Vsou_04420	COG0402	S-adenosylhomocysteine deaminase activity
Vsou_04490	COG0180	Tryptophanyl-tRNA synthetase
Vsou_04620	COG0189	ligase activity
Vsou_04670	COG0318	PFAM AMP-dependent synthetase and ligase
Vsou_04690	COG0318	PFAM AMP-dependent synthetase and ligase
Vsou_04780	COG0142	geranyltranstransferase activity
Vsou_04850	COG1363	Peptidase, m42
Vsou_04860	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Vsou_04880	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
Vsou_04920	COG1028	Short-chain dehydrogenase reductase Sdr
Vsou_05000	COG0200	Binds to the 23S rRNA
Vsou_05020	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Vsou_05050	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
Vsou_05080	COG0477	Major facilitator Superfamily
Vsou_05110	COG0668	transmembrane transport
Vsou_05140	COG0371	Dehydrogenase
Vsou_05190	COG1144	Oxidoreductase
Vsou_05200	COG0674	pyruvate-flavodoxin oxidoreductase activity
Vsou_05210	COG1013	pyruvate-flavodoxin oxidoreductase activity
Vsou_05260	COG0083	homoserine kinase activity
Vsou_05290	COG1210	Utp--glucose-1-phosphate uridylyltransferase
Vsou_05320	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Vsou_05350	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
Vsou_05480	COG0124	histidyl-tRNA synthetase
Vsou_05780	COG1331	Highly conserved protein containing a thioredoxin domain
Vsou_05810	COG0114	fumarate hydratase activity
Vsou_05820	COG1741	Belongs to the pirin family
Vsou_05880	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Vsou_05910	COG2897	thiosulfate sulfurtransferase activity
Vsou_05940	COG0312	modulator of DNA gyrase
Vsou_05960	COG0444	Belongs to the ABC transporter superfamily
Vsou_05970	COG4608	Belongs to the ABC transporter superfamily
Vsou_05980	COG0747	negative chemotaxis
Vsou_05990	COG0601	transmembrane transport
Vsou_06000	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Vsou_06020	COG0657	acetylesterase activity
Vsou_06040	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
Vsou_06060	COG0113	porphobilinogen synthase activity
Vsou_06070	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Vsou_06100	COG0489	protein tyrosine kinase activity
Vsou_06110	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Vsou_06280	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Vsou_06280	COG0731	radical SAM domain protein
Vsou_06350	COG0477	Major facilitator Superfamily
Vsou_06360	COG1304	FMN binding
Vsou_06380	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
Vsou_06530	COG1013	pyruvate-flavodoxin oxidoreductase activity
Vsou_06540	COG0674	pyruvate-flavodoxin oxidoreductase activity
Vsou_06560	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Vsou_06580	COG0010	Belongs to the arginase family
Vsou_06590	COG0423	glycine-tRNA ligase activity
Vsou_06600	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
Vsou_06630	COG1116	anion transmembrane transporter activity
Vsou_06630	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Vsou_06650	COG0725	ABC transporter, periplasmic molybdate-binding protein
Vsou_06660	COG4149	molybdate abc transporter
Vsou_06670	COG1250	3-hydroxyacyl-CoA dehydrogenase
Vsou_06680	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
Vsou_06800	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
Vsou_06850	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Vsou_06860	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
Vsou_06870	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
Vsou_06880	COG1429	ligase activity, forming nitrogen-metal bonds
Vsou_06920	COG4555	ABC transporter
Vsou_06930	COG0477	Major facilitator Superfamily
Vsou_06990	COG0584	glycerophosphoryl diester phosphodiesterase
Vsou_07000	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
Vsou_07020	COG2267	carboxylic ester hydrolase activity
Vsou_07060	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
Vsou_07100	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
Vsou_07140	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
Vsou_07180	COG1793	dna ligase
Vsou_07190	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
Vsou_07240	COG2813	Specifically methylates the guanine in position
Vsou_07300	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Vsou_07310	COG1584	GPR1 FUN34 yaaH family protein
Vsou_07320	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
Vsou_07450	COG1215	transferase activity, transferring glycosyl groups
Vsou_07470	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Vsou_07490	COG2192	nodulation
Vsou_07500	COG2890	protein-(glutamine-N5) methyltransferase activity
Vsou_07660	COG0301	tRNA thio-modification
Vsou_07660	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Vsou_07670	COG1515	deoxyribonuclease V activity
Vsou_07700	COG0531	amino acid
Vsou_07890	COG2723	6-phospho-beta-galactosidase activity
Vsou_07930	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Vsou_07930	COG0674	pyruvate-flavodoxin oxidoreductase activity
Vsou_07940	COG1013	pyruvate-flavodoxin oxidoreductase activity
Vsou_07970	COG0517	IMP dehydrogenase activity
Vsou_07970	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
Vsou_07980	COG0318	PFAM AMP-dependent synthetase and ligase
Vsou_07990	COG1960	acyl-CoA dehydrogenase activity
Vsou_08000	COG1309	transcriptional regulator
Vsou_08020	COG0318	PFAM AMP-dependent synthetase and ligase
Vsou_08030	COG2267	carboxylic ester hydrolase activity
Vsou_08080	COG1024	Enoyl-CoA hydratase
Vsou_08090	COG0277	FAD linked oxidase domain protein
Vsou_08140	COG1489	DNA binding
Vsou_08150	COG0252	asparaginase activity
Vsou_08160	COG3383	formate dehydrogenase (NAD+) activity
Vsou_08190	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
Vsou_08200	COG3383	formate dehydrogenase (NAD+) activity
Vsou_08310	COG0477	Major facilitator Superfamily
Vsou_08360	COG1358	cellular component organization or biogenesis
Vsou_08370	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
Vsou_08380	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
Vsou_08390	COG0085	RNA polymerase activity
Vsou_08410	COG0018	arginyl-trna synthetase
Vsou_08420	COG0012	GTP binding
Vsou_08460	COG0667	Aldo Keto reductase
Vsou_08470	COG1324	tolerance protein
Vsou_08480	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
Vsou_08490	COG0454	-acetyltransferase
Vsou_08490	COG0456	acetyltransferase
Vsou_08510	COG0459	protein refolding
Vsou_08620	COG0419	ATPase involved in DNA repair
Vsou_08900	COG1012	belongs to the aldehyde dehydrogenase family
Vsou_09140	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Vsou_09160	COG0697	spore germination
Vsou_09190	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
Vsou_09250	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
Vsou_09340	COG0167	dihydroorotate dehydrogenase activity
Vsou_09350	COG0284	orotidine-5'-phosphate decarboxylase activity
Vsou_09350	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
Vsou_09360	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
Vsou_09370	COG0540	Belongs to the ATCase OTCase family
Vsou_09390	COG3842	ATPase activity
Vsou_09400	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
Vsou_09440	COG0045	succinate-CoA ligase (ADP-forming) activity
Vsou_09450	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
Vsou_09470	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Vsou_09660	COG0586	Pfam SNARE associated Golgi protein
Vsou_09740	COG1136	(ABC) transporter
Vsou_09810	COG1013	pyruvate-flavodoxin oxidoreductase activity
Vsou_09980	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
Vsou_10020	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Vsou_10040	COG0456	acetyltransferase
Vsou_10100	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Vsou_10120	COG1702	phosphate starvation-inducible protein PhoH
Vsou_10130	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
Vsou_10140	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
Vsou_10190	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
Vsou_10270	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
Vsou_10280	COG0612	Peptidase, M16
Vsou_10290	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Vsou_10290	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Vsou_10350	COG0442	prolyl-tRNA aminoacylation
Vsou_10450	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
Vsou_10460	COG0318	PFAM AMP-dependent synthetase and ligase
Vsou_10490	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Vsou_10500	COG0569	domain protein
Vsou_10550	COG1492	cobalamin metabolic process
Vsou_10570	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
Vsou_10580	COG2095	MarC family integral membrane protein
Vsou_10750	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
Vsou_10770	COG1139	Iron-sulfur cluster binding protein
Vsou_10790	COG0651	ATP synthesis coupled electron transport
Vsou_10810	COG1444	tRNA N-acetyltransferase activity
Vsou_11020	COG0109	protoheme IX farnesyltransferase activity
Vsou_11020	COG1612	heme a metabolic process
Vsou_11050	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
Vsou_11070	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
Vsou_11110	COG1522	sequence-specific DNA binding
Vsou_11140	COG0281	malic enzyme
Vsou_11210	COG1201	RNA secondary structure unwinding
Vsou_11240	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
Vsou_11270	COG0089	rRNA binding
Vsou_11290	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
Vsou_11350	COG0200	Binds to the 23S rRNA
Vsou_11370	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
Vsou_11470	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
Vsou_11570	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Vsou_11600	COG0517	IMP dehydrogenase activity
Vsou_11600	COG0516	GMP reductase activity
Vsou_11700	COG0746	molybdenum cofactor guanylyltransferase activity
Vsou_11710	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
Vsou_11790	COG0463	Glycosyl transferase, family 2
Vsou_11870	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
Vsou_12000	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
Vsou_12060	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
Vsou_12160	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
Vsou_12170	COG1185	polyribonucleotide nucleotidyltransferase activity
Vsou_12180	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
Vsou_12200	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
Vsou_12210	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
Vsou_12220	COG0644	oxidoreductase
Vsou_12310	COG2890	protein-(glutamine-N5) methyltransferase activity
Vsou_12330	COG0071	Belongs to the small heat shock protein (HSP20) family
Vsou_12390	COG2078	PFAM AMMECR1 domain protein
Vsou_12420	COG0546	phosphoglycolate phosphatase activity
Vsou_12470	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
Vsou_12480	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Vsou_12520	COG2226	methyltransferase
Vsou_12560	COG0671	phosphoesterase, PA-phosphatase related
Vsou_12570	COG1121	(ABC) transporter
Vsou_12690	COG0477	Major facilitator Superfamily
Vsou_12780	COG1058	Belongs to the CinA family
Vsou_12780	COG1546	Belongs to the CinA family
Vsou_12850	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
Vsou_12940	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
Vsou_13020	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
Vsou_13020	COG1648	precorrin-2 dehydrogenase activity
Vsou_13030	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
Vsou_13050	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
Vsou_13260	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
Vsou_13410	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
Vsou_13740	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
Vsou_13770	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
Vsou_13770	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
Vsou_13790	COG0148	phosphopyruvate hydratase activity
Vsou_13800	COG0052	Belongs to the universal ribosomal protein uS2 family
Vsou_13810	COG1355	regulation of microtubule-based process
Vsou_13880	COG3118	belongs to the thioredoxin family
Vsou_13900	COG0174	glutamine synthetase
Vsou_13910	COG0004	ammonium transporteR
Vsou_13990	COG0516	GMP reductase activity
Vsou_13990	COG0517	IMP dehydrogenase activity
Vsou_14000	COG0495	leucyl-tRNA aminoacylation
Vsou_14090	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Vsou_14100	COG0051	transcription antitermination factor activity, RNA binding
Vsou_14120	COG0612	Peptidase, M16
Vsou_14130	COG0137	argininosuccinate synthase activity
Vsou_14160	COG0165	Argininosuccinate lyase
Vsou_14170	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
Vsou_14180	COG0505	Belongs to the CarA family
Vsou_14190	COG0436	Aminotransferase
Vsou_14200	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
Vsou_14220	COG0189	ligase activity
Vsou_14230	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Vsou_14240	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Vsou_14250	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Vsou_14260	COG0189	ligase activity
Vsou_14280	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
Vsou_14310	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
Vsou_14370	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
Vsou_14380	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
Vsou_14400	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
Vsou_14410	COG0477	Major facilitator Superfamily
Vsou_14420	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
Vsou_14440	COG0574	Belongs to the PEP-utilizing enzyme family
Vsou_14440	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Vsou_14450	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Vsou_14450	COG0512	Glutamine amidotransferase of anthranilate synthase
Vsou_14460	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
Vsou_14470	COG0135	phosphoribosylanthranilate isomerase activity
Vsou_14480	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Vsou_14490	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
Vsou_14500	COG0159	tryptophan synthase activity
Vsou_14510	COG0134	indole-3-glycerol-phosphate synthase activity
Vsou_14530	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
Vsou_14540	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
Vsou_14550	COG0083	homoserine kinase activity
Vsou_14570	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
Vsou_14580	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
Vsou_14590	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
Vsou_14600	COG1605	Chorismate mutase
Vsou_14600	COG0077	Prephenate dehydratase
Vsou_14630	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
Vsou_14650	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
Vsou_14660	COG0518	GMP synthase (glutamine-hydrolyzing) activity
Vsou_14660	COG0519	Catalyzes the synthesis of GMP from XMP
Vsou_14690	COG0402	S-adenosylhomocysteine deaminase activity
Vsou_14770	COG0517	IMP dehydrogenase activity
Vsou_14770	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
Vsou_14770	COG0617	tRNA 3'-terminal CCA addition
Vsou_14780	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
Vsou_14800	COG0420	3'-5' exonuclease activity
Vsou_14810	COG0419	ATPase involved in DNA repair
Vsou_14840	COG0475	glutathione-regulated potassium exporter activity
Vsou_14930	COG1131	(ABC) transporter
Vsou_14950	COG0539	negative regulation of cytoplasmic translation
Vsou_14950	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
Vsou_14970	COG0023	Translation Initiation Factor
Vsou_14990	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
Vsou_15000	COG1201	RNA secondary structure unwinding
Vsou_15100	COG1192	Involved in chromosome partitioning
Vsou_15160	COG1136	(ABC) transporter
Vsou_15310	COG2814	Major facilitator Superfamily
Vsou_15340	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Vsou_15380	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
Vsou_15450	COG0277	FAD linked oxidase domain protein
Vsou_15460	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
Vsou_15480	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Vsou_15540	COG1960	acyl-CoA dehydrogenase activity
Vsou_15570	COG0028	Belongs to the TPP enzyme family
Vsou_15580	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Vsou_15600	COG1250	3-hydroxyacyl-CoA dehydrogenase
Vsou_15610	COG0183	Belongs to the thiolase family
Vsou_15630	COG1024	Enoyl-CoA hydratase
Vsou_15660	COG0318	PFAM AMP-dependent synthetase and ligase
Vsou_15700	COG0483	inositol monophosphate 1-phosphatase activity
Vsou_15930	COG1618	nucleotide phosphatase activity, acting on free nucleotides
Vsou_15960	COG0719	Fe-S assembly protein
Vsou_15970	COG0719	Fe-S assembly protein
Vsou_15980	COG0719	Fe-S assembly protein
Vsou_16010	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
Vsou_16020	COG0527	aspartate kinase activity
Vsou_16030	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Vsou_16060	COG0066	3-isopropylmalate dehydratase activity
Vsou_16090	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
Vsou_16110	COG1013	pyruvate-flavodoxin oxidoreductase activity
Vsou_16120	COG0674	pyruvate-flavodoxin oxidoreductase activity
Vsou_16140	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Vsou_16160	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Vsou_16170	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
Vsou_16190	COG0028	Belongs to the TPP enzyme family
Vsou_16210	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Vsou_16230	COG0473	3-isopropylmalate dehydrogenase activity
Vsou_16240	COG0067	glutamate synthase
Vsou_16250	COG0069	glutamate synthase activity
Vsou_16250	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
Vsou_16260	COG0077	Prephenate dehydratase
Vsou_16260	COG1605	Chorismate mutase
Vsou_16270	COG1892	Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four- carbon dicarboxylic acid source for the tricarboxylic acid cycle
Vsou_16320	COG0477	Major facilitator Superfamily
Vsou_16330	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
Vsou_16350	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Vsou_16450	COG1867	N(2),N(2)-dimethylguanosine tRNA methyltransferase
Vsou_16470	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
Vsou_16520	COG0574	Belongs to the PEP-utilizing enzyme family
Vsou_16520	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Vsou_16530	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
Vsou_16580	COG0535	radical SAM domain protein
Vsou_16590	COG0535	radical SAM domain protein
Vsou_16660	COG1529	Aldehyde oxidase and xanthine dehydrogenase
Vsou_16700	COG2409	Drug exporters of the RND superfamily
Vsou_16710	COG1136	(ABC) transporter
Vsou_16730	COG0302	gtp cyclohydrolase
Vsou_16750	COG0129	dihydroxy-acid dehydratase activity
Vsou_16760	COG1881	PFAM PEBP family protein
Vsou_16880	COG0303	'Molybdopterin
Vsou_16920	COG0318	PFAM AMP-dependent synthetase and ligase
Vsou_16930	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Vsou_16940	COG0069	glutamate synthase activity
Vsou_16950	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
Vsou_17030	COG0255	Belongs to the universal ribosomal protein uL29 family
Vsou_17060	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
Vsou_17080	COG0215	cysteine-tRNA ligase activity
Vsou_17110	COG1830	Aldolase
Vsou_17150	COG2721	sulfolactate sulfo-lyase activity
Vsou_17190	COG2084	Dehydrogenase
Vsou_17230	COG1172	Belongs to the binding-protein-dependent transport system permease family
Vsou_17270	COG3386	PFAM SMP-30 Gluconolaconase
Vsou_17320	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Vsou_17540	COG0436	Aminotransferase
Vsou_17580	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
Vsou_17750	COG2192	nodulation
Vsou_17790	COG0463	Glycosyl transferase, family 2
Vsou_17790	COG1216	Glycosyl transferase, family 2
Vsou_17810	COG0438	transferase activity, transferring glycosyl groups
Vsou_17890	COG0438	transferase activity, transferring glycosyl groups
Vsou_17910	COG0438	transferase activity, transferring glycosyl groups
Vsou_17920	COG0438	transferase activity, transferring glycosyl groups
Vsou_17960	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Vsou_17980	COG0438	transferase activity, transferring glycosyl groups
Vsou_18000	COG0297	glycogen (starch) synthase activity
Vsou_18010	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Vsou_18220	COG0714	Associated with various cellular activities
Vsou_18260	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
Vsou_18290	COG3273	potassium ion transport
Vsou_18290	COG0471	metal ion transport
Vsou_18300	COG1028	Short-chain dehydrogenase reductase Sdr
Vsou_18360	COG3118	belongs to the thioredoxin family
Vsou_18370	COG1335	isochorismatase
Vsou_18390	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
Vsou_18420	COG2226	methyltransferase
Vsou_18440	COG1028	Short-chain dehydrogenase reductase Sdr
Vsou_18500	COG0425	Belongs to the sulfur carrier protein TusA family
Vsou_18600	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
Vsou_18630	COG0714	Associated with various cellular activities
Vsou_18660	COG1960	acyl-CoA dehydrogenase activity
Vsou_18670	COG1960	acyl-CoA dehydrogenase activity
Vsou_18680	COG1573	uracil-dna glycosylase
Vsou_18720	COG1980	fructose-bisphosphate aldolase activity
Vsou_18940	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
Vsou_18950	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
Vsou_18970	COG0149	triose-phosphate isomerase activity
Vsou_19090	COG0101	tRNA pseudouridine synthase activity
Vsou_19110	COG1254	Belongs to the acylphosphatase family
Vsou_19220	COG0667	Aldo Keto reductase
Vsou_19270	COG2814	Major facilitator Superfamily
Vsou_19330	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
Vsou_19330	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
Vsou_19350	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
Vsou_19370	COG1028	Short-chain dehydrogenase reductase Sdr
Vsou_19380	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
Vsou_19390	COG1754	DNA topoisomerase type I activity
Vsou_19390	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
Vsou_19440	COG1960	acyl-CoA dehydrogenase activity
Vsou_19490	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
Vsou_19540	COG2855	membrane
Vsou_19570	COG0010	Belongs to the arginase family
Vsou_19660	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
Vsou_19690	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
Vsou_19700	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
Vsou_19710	COG2986	histidine ammonia-lyase
Vsou_19720	COG0436	Aminotransferase
Vsou_19730	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
Vsou_19740	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
Vsou_19760	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
Vsou_19790	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
Vsou_19800	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
Vsou_19810	COG0140	phosphoribosyl-ATP diphosphatase activity
Vsou_19820	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
Vsou_19840	COG0107	imidazoleglycerol-phosphate synthase activity
Vsou_19850	COG0131	Imidazoleglycerol-phosphate dehydratase
Vsou_19860	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
Vsou_19870	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
Vsou_19880	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Vsou_19920	COG0585	pseudouridine synthase activity
Vsou_20060	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
Vsou_20080	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
Vsou_20100	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Vsou_20100	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Vsou_20120	COG0315	cyclic pyranopterin monophosphate synthase activity
Vsou_20130	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
Vsou_20150	COG1260	myo-inositol-1-phosphate synthase
Vsou_20170	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
Vsou_20180	COG1013	pyruvate-flavodoxin oxidoreductase activity
Vsou_20190	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Vsou_20190	COG0674	pyruvate-flavodoxin oxidoreductase activity
Vsou_20280	COG3189	MarR family transcriptional regulator
Vsou_20320	COG1720	tRNA m6t6A37 methyltransferase activity
Vsou_20390	COG2181	nitrate reductase activity
Vsou_20400	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
Vsou_20410	COG1140	nitrate reductase beta subunit
Vsou_20470	COG2379	hydroxypyruvate reductase
Vsou_20570	COG0528	UMP kinase activity
Vsou_20590	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
Vsou_20630	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Vsou_20740	COG0318	PFAM AMP-dependent synthetase and ligase
Vsou_20750	COG1960	acyl-CoA dehydrogenase activity
Vsou_20770	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
Vsou_20770	COG3266	domain, Protein
Vsou_20800	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
Vsou_20810	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
Vsou_20820	COG1047	Peptidyl-prolyl cis-trans
Vsou_20850	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Vsou_20870	COG0504	CTP synthase activity
Vsou_21000	COG0084	hydrolase, TatD family'
Vsou_21060	COG0189	ligase activity
Vsou_21130	COG1979	alcohol dehydrogenase
Vsou_21150	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
Vsou_21250	COG3118	belongs to the thioredoxin family
Vsou_21260	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
Vsou_21290	COG0501	Belongs to the peptidase M48B family
Vsou_21370	COG1372	Participates in initiation and elongation during chromosome replication
Vsou_21370	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
Vsou_21380	COG2222	sugar isomerase
Vsou_21400	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
Vsou_21450	COG2095	MarC family integral membrane protein
Vsou_21520	COG0351	phosphomethylpyrimidine kinase
Vsou_21610	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
Vsou_21630	COG4946	Tricorn protease homolog
Vsou_21630	COG1506	peptidase
Vsou_21630	COG0823	Involved in the tonB-independent uptake of proteins
Vsou_21670	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
Vsou_21680	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Vsou_21750	COG1007	ATP synthesis coupled electron transport
Vsou_21850	COG0437	4 iron, 4 sulfur cluster binding
Vsou_21860	COG0243	molybdopterin cofactor binding
Vsou_21870	COG3301	Polysulphide reductase, NrfD
Vsou_21970	COG0805	protein transport
Vsou_22000	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Vsou_22020	COG0450	alkyl hydroperoxide reductase
Vsou_22120	COG1024	Enoyl-CoA hydratase
Vsou_22130	COG2414	aldehyde ferredoxin oxidoreductase
Vsou_22170	COG1940	carbohydrate kinase activity
Vsou_22270	COG1110	DNA topoisomerase II activity
Vsou_22330	COG0674	pyruvate-flavodoxin oxidoreductase activity
Vsou_22330	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Vsou_22340	COG1013	pyruvate-flavodoxin oxidoreductase activity
Vsou_22360	COG1233	COG1233 Phytoene dehydrogenase and related
Vsou_22370	COG2181	nitrate reductase activity
Vsou_22370	COG0247	lactate metabolic process
Vsou_22380	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
Vsou_22390	COG2086	electron transfer activity
Vsou_22420	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Vsou_22440	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
Vsou_22450	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
Vsou_22460	COG2255	four-way junction helicase activity
Vsou_22470	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
Vsou_22540	COG4555	ABC transporter
Vsou_22560	COG0017	Asparaginyl-tRNA synthetase
Vsou_22580	COG2814	Major facilitator Superfamily
Vsou_22590	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
Vsou_22620	COG1063	alcohol dehydrogenase
Vsou_22660	COG0492	ferredoxin-NADP+ reductase activity
Vsou_22680	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
Vsou_22690	COG0516	GMP reductase activity
Vsou_22690	COG0517	IMP dehydrogenase activity
Vsou_22750	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
Vsou_23090	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
Vsou_23100	COG0183	Belongs to the thiolase family
Vsou_23110	COG0735	belongs to the Fur family
Vsou_23120	COG1592	Rubrerythrin
Vsou_23140	COG2271	Major facilitator Superfamily
Vsou_23150	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Vsou_23200	COG0049	tRNA binding
Vsou_23220	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Vsou_23240	COG2860	membrane
Vsou_23260	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
Vsou_23300	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
Vsou_23320	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
Vsou_23330	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
Vsou_23340	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Vsou_23350	COG1228	amidohydrolase
Vsou_23460	COG0516	GMP reductase activity
Vsou_23460	COG0517	IMP dehydrogenase activity
Vsou_23500	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
Vsou_23540	COG0516	GMP reductase activity
Vsou_23540	COG0517	IMP dehydrogenase activity
Vsou_23570	COG0649	NAD binding
Vsou_23570	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Vsou_23570	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Vsou_23580	COG0649	NAD binding
Vsou_23690	COG1960	acyl-CoA dehydrogenase activity
Vsou_23700	COG1960	acyl-CoA dehydrogenase activity
Vsou_23710	COG0318	PFAM AMP-dependent synthetase and ligase
Vsou_23740	COG1250	3-hydroxyacyl-CoA dehydrogenase
Vsou_23770	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
Vsou_23790	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
Vsou_23850	COG3829	transcription factor binding
Vsou_23900	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
Vsou_24000	COG1960	acyl-CoA dehydrogenase activity
Vsou_24140	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
Vsou_24150	COG2226	methyltransferase
Vsou_24350	COG0531	amino acid
Vsou_24400	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
Vsou_24440	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
Vsou_24480	COG1271	oxidase subunit
Vsou_24490	COG0446	pyridine nucleotide-disulphide oxidoreductase
Vsou_24570	COG1546	Belongs to the CinA family
Vsou_24570	COG1058	Belongs to the CinA family
Vsou_24600	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Vsou_24630	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
Vsou_24640	COG2086	electron transfer activity
Vsou_24660	COG0644	oxidoreductase
Vsou_24670	COG0535	radical SAM domain protein
Vsou_24680	COG1032	radical SAM domain protein
Vsou_24720	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
Vsou_24910	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
Vsou_24990	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
Vsou_25000	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
Vsou_25010	COG4948	Mandelate Racemase Muconate Lactonizing
Vsou_25070	COG0318	PFAM AMP-dependent synthetase and ligase
Vsou_25130	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
Vsou_25140	COG0477	Major facilitator Superfamily
Vsou_25150	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
Vsou_25270	COG0277	FAD linked oxidase domain protein
Vsou_25280	COG0247	lactate metabolic process
Vsou_25310	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
Vsou_25320	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
Vsou_25330	COG0492	ferredoxin-NADP+ reductase activity
Vsou_25340	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
Vsou_25350	COG0531	amino acid
Vsou_25360	COG2210	Belongs to the sulfur carrier protein TusA family
Vsou_25380	COG0446	pyridine nucleotide-disulphide oxidoreductase
Vsou_25420	COG1085	galactose-1-phosphate uridylyltransferase
Vsou_25460	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Vsou_25460	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
Vsou_25540	COG0656	L-ascorbic acid biosynthetic process
Vsou_25580	COG2920	part of a sulfur-relay system
Vsou_25600	COG2221	Nitrite and sulphite reductase 4Fe-4S
Vsou_25610	COG2221	Nitrite and sulphite reductase 4Fe-4S
Vsou_25700	COG2046	Belongs to the sulfate adenylyltransferase family
Vsou_25740	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
Vsou_25970	COG0601	transmembrane transport
Vsou_25980	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Vsou_25990	COG0444	Belongs to the ABC transporter superfamily
Vsou_26000	COG4608	Belongs to the ABC transporter superfamily
Vsou_26070	COG0301	tRNA thio-modification
Vsou_26080	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Vsou_26090	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
Vsou_26100	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
Vsou_26110	COG0105	UTP biosynthetic process
Vsou_26120	COG1063	alcohol dehydrogenase
Vsou_26140	COG0494	nUDIX hydrolase
Vsou_26150	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Vsou_26180	COG0538	isocitrate dehydrogenase activity
Vsou_26190	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Vsou_26190	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
Vsou_26220	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
Vsou_26230	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
Vsou_26250	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
Vsou_26300	COG3276	selenocysteine insertion sequence binding
Vsou_26320	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Vsou_26320	COG0674	pyruvate-flavodoxin oxidoreductase activity
Vsou_26330	COG1063	alcohol dehydrogenase
Vsou_26340	COG4948	Mandelate Racemase Muconate Lactonizing
Vsou_26360	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Vsou_26370	COG0805	protein transport
Vsou_26410	COG1653	transport
Vsou_26430	COG1129	ABC transporter
Vsou_26450	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Vsou_26470	COG2414	aldehyde ferredoxin oxidoreductase
Vsou_26480	COG4948	Mandelate Racemase Muconate Lactonizing
Vsou_26500	COG0028	Belongs to the TPP enzyme family
Vsou_26520	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
Vsou_26540	COG0277	FAD linked oxidase domain protein
Vsou_26550	COG2814	Major facilitator Superfamily