locus-tag	class	description
AKJ08_0001	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AKJ08_0005	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AKJ08_0006	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AKJ08_0007	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AKJ08_0010	COG0483	inositol monophosphate 1-phosphatase activity
AKJ08_0011	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AKJ08_0012	COG1666	GTP binding
AKJ08_0013	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AKJ08_0016	COG2373	Large extracellular alpha-helical protein
AKJ08_0017	COG2373	Large extracellular alpha-helical protein
AKJ08_0021	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AKJ08_0024	COG3706	GGDEF domain
AKJ08_0027	COG0297	glycogen (starch) synthase activity
AKJ08_0029	COG4412	M6 family metalloprotease domain protein
AKJ08_0029	COG3291	Pkd domain containing protein
AKJ08_0031	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AKJ08_0032	COG0047	phosphoribosylformylglycinamidine synthase activity
AKJ08_0033	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AKJ08_0035	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AKJ08_0043	COG2801	Transposase and inactivated derivatives
AKJ08_0044	COG4412	M6 family metalloprotease domain protein
AKJ08_0044	COG3291	Pkd domain containing protein
AKJ08_0045	COG4412	M6 family metalloprotease domain protein
AKJ08_0045	COG3291	Pkd domain containing protein
AKJ08_0051	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
AKJ08_0054	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
AKJ08_0057	COG0713	ATP synthesis coupled electron transport
AKJ08_0058	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AKJ08_0062	COG2204	response regulator
AKJ08_0063	COG4191	Histidine kinase
AKJ08_0064	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AKJ08_0066	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
AKJ08_0073	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AKJ08_0074	COG0590	tRNA wobble adenosine to inosine editing
AKJ08_0076	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AKJ08_0077	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AKJ08_0080	COG1013	pyruvate-flavodoxin oxidoreductase activity
AKJ08_0081	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
AKJ08_0081	COG0674	pyruvate-flavodoxin oxidoreductase activity
AKJ08_0087	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
AKJ08_0088	COG1074	ATP-dependent DNA helicase activity
AKJ08_0099	COG0545	Peptidyl-prolyl cis-trans isomerase
AKJ08_0102	COG1012	belongs to the aldehyde dehydrogenase family
AKJ08_0103	COG0463	Glycosyl transferase, family 2
AKJ08_0104	COG1368	sulfuric ester hydrolase activity
AKJ08_0116	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
AKJ08_0117	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
AKJ08_0122	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AKJ08_0125	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AKJ08_0126	COG0390	transport system, permease component
AKJ08_0127	COG1129	ABC transporter
AKJ08_0130	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AKJ08_0133	COG1703	isobutyryl-CoA mutase activity
AKJ08_0134	COG2205	protein histidine kinase activity
AKJ08_0135	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
AKJ08_0138	COG0439	Biotin carboxylase
AKJ08_0139	COG0511	ligase activity, forming carbon-carbon bonds
AKJ08_0150	COG0564	pseudouridine synthase activity
AKJ08_0151	COG0617	tRNA 3'-terminal CCA addition
AKJ08_0153	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AKJ08_0154	COG0473	3-isopropylmalate dehydrogenase activity
AKJ08_0155	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AKJ08_0163	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AKJ08_0165	COG5520	Belongs to the glycosyl hydrolase 30 family
AKJ08_0165	COG3291	Pkd domain containing protein
AKJ08_0165	COG4447	cellulose binding
AKJ08_0167	COG0484	heat shock protein binding
AKJ08_0168	COG0443	Heat shock 70 kDa protein
AKJ08_0172	COG0237	dephospho-CoA kinase activity
AKJ08_0173	COG0218	Necessary for normal cell division and for the maintenance of normal septation
AKJ08_0185	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AKJ08_0187	COG0484	heat shock protein binding
AKJ08_0188	COG2385	sporulation resulting in formation of a cellular spore
AKJ08_0191	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AKJ08_0192	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AKJ08_0193	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AKJ08_0198	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AKJ08_0207	COG1138	Cytochrome C-type biogenesis protein
AKJ08_0208	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
AKJ08_0210	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AKJ08_0212	COG1131	(ABC) transporter
AKJ08_0213	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AKJ08_0216	COG2226	methyltransferase
AKJ08_0217	COG0163	prenyltransferase activity
AKJ08_0219	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
AKJ08_0220	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
AKJ08_0222	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AKJ08_0223	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
AKJ08_0224	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
AKJ08_0227	COG0438	transferase activity, transferring glycosyl groups
AKJ08_0230	COG2755	lipolytic protein G-D-S-L family
AKJ08_0230	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
AKJ08_0243	COG0318	PFAM AMP-dependent synthetase and ligase
AKJ08_0244	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AKJ08_0245	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AKJ08_0252	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AKJ08_0253	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AKJ08_0254	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AKJ08_0260	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AKJ08_0262	COG0285	dihydrofolate synthase activity
AKJ08_0265	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
AKJ08_0266	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AKJ08_0267	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
AKJ08_0268	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
AKJ08_0270	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AKJ08_0272	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AKJ08_0273	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AKJ08_0277	COG2259	Doxx family
AKJ08_0280	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AKJ08_0280	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
AKJ08_0281	COG3795	YCII-related domain
AKJ08_0283	COG4941	Belongs to the sigma-70 factor family
AKJ08_0285	COG3384	dioxygenase
AKJ08_0290	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AKJ08_0291	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AKJ08_0294	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AKJ08_0295	COG1597	lipid kinase activity
AKJ08_0303	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AKJ08_0304	COG0352	thiamine-phosphate diphosphorylase activity
AKJ08_0305	COG2022	thiamine diphosphate biosynthetic process
AKJ08_0309	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AKJ08_0310	COG0456	acetyltransferase
AKJ08_0311	COG0156	8-amino-7-oxononanoate synthase activity
AKJ08_0313	COG2937	Belongs to the GPAT DAPAT family
AKJ08_0314	COG2201	protein-glutamate methylesterase activity
AKJ08_0315	COG5002	protein histidine kinase activity
AKJ08_0319	COG0456	acetyltransferase
AKJ08_0320	COG0167	dihydroorotate dehydrogenase activity
AKJ08_0323	COG0602	queuosine metabolic process
AKJ08_0327	COG1381	Involved in DNA repair and RecF pathway recombination
AKJ08_0328	COG0300	oxidoreductase activity
AKJ08_0329	COG0277	FAD linked oxidase domain protein
AKJ08_0332	COG1028	Short-chain dehydrogenase reductase Sdr
AKJ08_0334	COG0552	protein localization to endoplasmic reticulum
AKJ08_0335	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AKJ08_0339	COG2223	nitrite transmembrane transporter activity
AKJ08_0340	COG0406	alpha-ribazole phosphatase activity
AKJ08_0340	COG0328	RNA-DNA hybrid ribonuclease activity
AKJ08_0344	COG1610	YqeY-like protein
AKJ08_0347	COG0776	regulation of translation
AKJ08_0348	COG1295	ribonuclease BN
AKJ08_0348	COG1959	2 iron, 2 sulfur cluster binding
AKJ08_0349	COG1530	ribonuclease E activity
AKJ08_0355	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AKJ08_0357	COG1408	metallophosphoesterase
AKJ08_0358	COG0110	maltose O-acetyltransferase activity
AKJ08_0360	COG0577	efflux transmembrane transporter activity
AKJ08_0360	COG1136	(ABC) transporter
AKJ08_0361	COG1136	(ABC) transporter
AKJ08_0361	COG0577	efflux transmembrane transporter activity
AKJ08_0363	COG0494	nUDIX hydrolase
AKJ08_0369	COG0300	oxidoreductase activity
AKJ08_0371	COG0714	Associated with various cellular activities
AKJ08_0380	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AKJ08_0387	COG0585	pseudouridine synthase activity
AKJ08_0390	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AKJ08_0390	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AKJ08_0391	COG2226	methyltransferase
AKJ08_0392	COG0252	asparaginase activity
AKJ08_0398	COG2890	protein-(glutamine-N5) methyltransferase activity
AKJ08_0403	COG0779	Required for maturation of 30S ribosomal subunits
AKJ08_0404	COG0195	Participates in both transcription termination and antitermination
AKJ08_0404	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AKJ08_0408	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AKJ08_0409	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AKJ08_0410	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AKJ08_0411	COG1185	polyribonucleotide nucleotidyltransferase activity
AKJ08_0421	COG0308	aminopeptidase N
AKJ08_0422	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AKJ08_0424	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AKJ08_0425	COG2076	Multidrug Resistance protein
AKJ08_0426	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AKJ08_0429	COG1757	Na H antiporter
AKJ08_0432	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AKJ08_0436	COG2078	PFAM AMMECR1 domain protein
AKJ08_0436	COG3885	ferrous iron binding
AKJ08_0440	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AKJ08_0441	COG1051	belongs to the nudix hydrolase family
AKJ08_0443	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AKJ08_0444	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AKJ08_0445	COG4932	domain protein
AKJ08_0445	COG1388	LysM domain
AKJ08_0445	COG2373	Large extracellular alpha-helical protein
AKJ08_0448	COG0066	3-isopropylmalate dehydratase activity
AKJ08_0449	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AKJ08_0452	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AKJ08_0456	COG1012	belongs to the aldehyde dehydrogenase family
AKJ08_0457	COG1024	Enoyl-CoA hydratase
AKJ08_0459	COG1764	response to oxidative stress
AKJ08_0465	COG1024	Enoyl-CoA hydratase
AKJ08_0466	COG1250	3-hydroxyacyl-CoA dehydrogenase
AKJ08_0486	COG1899	peptidyl-lysine modification to peptidyl-hypusine
AKJ08_0489	COG0784	Response regulator, receiver
AKJ08_0489	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AKJ08_0489	COG2198	Histidine kinase
AKJ08_0489	COG2205	protein histidine kinase activity
AKJ08_0493	COG0714	Associated with various cellular activities
AKJ08_0494	COG1305	Transglutaminase-like
AKJ08_0495	COG0488	(ABC) transporter
AKJ08_0498	COG0416	fatty acid biosynthetic process
AKJ08_0501	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AKJ08_0502	COG2096	Adenosyltransferase
AKJ08_0505	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AKJ08_0507	COG1181	Belongs to the D-alanine--D-alanine ligase family
AKJ08_0510	COG4191	Histidine kinase
AKJ08_0514	COG2885	chlorophyll binding
AKJ08_0516	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AKJ08_0517	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AKJ08_0519	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AKJ08_0522	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
AKJ08_0527	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
AKJ08_0529	COG0309	Hydrogenase expression formation protein (HypE)
AKJ08_0530	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
AKJ08_0532	COG0298	carbon dioxide binding
AKJ08_0533	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
AKJ08_0534	COG0375	protein maturation
AKJ08_0545	COG0745	RESPONSE REGULATOR receiver
AKJ08_0546	COG5002	protein histidine kinase activity
AKJ08_0550	COG2719	SpoVR family
AKJ08_0551	COG2718	Belongs to the UPF0229 family
AKJ08_0552	COG2766	serine protein kinase
AKJ08_0554	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AKJ08_0556	COG0432	Pfam Uncharacterised protein family UPF0047
AKJ08_0560	COG1192	Involved in chromosome partitioning
AKJ08_0561	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
AKJ08_0564	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
AKJ08_0566	COG1999	signal sequence binding
AKJ08_0567	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AKJ08_0567	COG0515	serine threonine protein kinase
AKJ08_0568	COG2146	nitrite reductase [NAD(P)H] activity
AKJ08_0568	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AKJ08_0572	COG1215	transferase activity, transferring glycosyl groups
AKJ08_0576	COG0584	glycerophosphoryl diester phosphodiesterase
AKJ08_0580	COG0693	protein deglycase activity
AKJ08_0584	COG0189	ligase activity
AKJ08_0586	COG0793	Belongs to the peptidase S41A family
AKJ08_0587	COG0189	ligase activity
AKJ08_0591	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AKJ08_0593	COG0584	glycerophosphoryl diester phosphodiesterase
AKJ08_0600	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AKJ08_0607	COG0860	N-Acetylmuramoyl-L-alanine amidase
AKJ08_0608	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AKJ08_0609	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AKJ08_0611	COG0544	peptidyl-prolyl cis-trans isomerase activity
AKJ08_0612	COG0740	serine-type endopeptidase activity
AKJ08_0618	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AKJ08_0620	COG3387	PFAM Glycoside hydrolase 15-related
AKJ08_0622	COG4948	Mandelate Racemase Muconate Lactonizing
AKJ08_0623	COG0028	Belongs to the TPP enzyme family
AKJ08_0624	COG0277	FAD linked oxidase domain protein
AKJ08_0624	COG0247	lactate metabolic process
AKJ08_0632	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AKJ08_0632	COG1845	cytochrome c oxidase, subunit III
AKJ08_0633	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AKJ08_0639	COG0437	4 iron, 4 sulfur cluster binding
AKJ08_0640	COG0243	molybdopterin cofactor binding
AKJ08_0643	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
AKJ08_0643	COG1796	DNA polymerase
AKJ08_0645	COG0567	Dehydrogenase, E1 component
AKJ08_0646	COG0508	dehydrogenase complex catalyzes the overall conversion of
AKJ08_0650	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AKJ08_0651	COG0408	coproporphyrinogen oxidase activity
AKJ08_0652	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AKJ08_0656	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AKJ08_0657	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AKJ08_0658	COG0497	DNA recombination
AKJ08_0661	COG0739	heme binding
AKJ08_0662	COG0653	protein targeting
AKJ08_0663	COG0052	Belongs to the universal ribosomal protein uS2 family
AKJ08_0664	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AKJ08_0665	COG0528	UMP kinase activity
AKJ08_0666	COG0233	cytoplasmic translational termination
AKJ08_0672	COG0009	L-threonylcarbamoyladenylate synthase
AKJ08_0677	COG2333	competence protein COMEC
AKJ08_0677	COG0658	competence protein
AKJ08_0679	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
AKJ08_0681	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
AKJ08_0682	COG0295	cytidine deaminase activity
AKJ08_0684	COG0196	riboflavin kinase activity
AKJ08_0685	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AKJ08_0688	COG3852	Histidine kinase
AKJ08_0698	COG4968	Prepilin-type N-terminal cleavage methylation domain
AKJ08_0699	COG1131	(ABC) transporter
AKJ08_0700	COG3119	arylsulfatase activity
AKJ08_0701	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
AKJ08_0702	COG4191	Histidine kinase
AKJ08_0703	COG2204	response regulator
AKJ08_0712	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AKJ08_0714	COG0439	Biotin carboxylase
AKJ08_0728	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AKJ08_0730	COG3959	Transketolase, thiamine diphosphate binding domain
AKJ08_0731	COG3958	Transketolase
AKJ08_0732	COG2884	Cell division ATP-binding protein ftsE
AKJ08_0733	COG2177	Part of the ABC transporter FtsEX involved in
AKJ08_0735	COG2267	carboxylic ester hydrolase activity
AKJ08_0736	COG0793	Belongs to the peptidase S41A family
AKJ08_0738	COG0443	Heat shock 70 kDa protein
AKJ08_0739	COG2766	serine protein kinase
AKJ08_0745	COG4565	transcriptional regulatory protein
AKJ08_0749	COG2204	response regulator
AKJ08_0750	COG0745	RESPONSE REGULATOR receiver
AKJ08_0750	COG3706	GGDEF domain
AKJ08_0754	COG0110	maltose O-acetyltransferase activity
AKJ08_0764	COG2030	dehydratase
AKJ08_0768	COG1253	flavin adenine dinucleotide binding
AKJ08_0771	COG1846	Transcriptional regulator
AKJ08_0773	COG0741	lytic transglycosylase activity
AKJ08_0777	COG0166	Belongs to the GPI family
AKJ08_0778	COG0204	Acyl-transferase
AKJ08_0780	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AKJ08_0790	COG0515	serine threonine protein kinase
AKJ08_0790	COG2815	serine threonine protein kinase
AKJ08_0793	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AKJ08_0793	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AKJ08_0800	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AKJ08_0801	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AKJ08_0802	COG1438	arginine binding
AKJ08_0803	COG0137	argininosuccinate synthase activity
AKJ08_0804	COG0165	Argininosuccinate lyase
AKJ08_0807	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AKJ08_0809	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AKJ08_0810	COG0585	pseudouridine synthase activity
AKJ08_0818	COG0513	Belongs to the DEAD box helicase family
AKJ08_0822	COG4608	Belongs to the ABC transporter superfamily
AKJ08_0823	COG0444	Belongs to the ABC transporter superfamily
AKJ08_0824	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AKJ08_0825	COG0601	transmembrane transport
AKJ08_0826	COG4166	transmembrane transport
AKJ08_0831	COG4783	chaperone-mediated protein folding
AKJ08_0834	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AKJ08_0834	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AKJ08_0839	COG0084	hydrolase, TatD family'
AKJ08_0843	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
AKJ08_0847	COG0149	triose-phosphate isomerase activity
AKJ08_0852	COG0318	PFAM AMP-dependent synthetase and ligase
AKJ08_0855	COG1960	acyl-CoA dehydrogenase activity
AKJ08_0857	COG1132	(ABC) transporter
AKJ08_0858	COG0517	IMP dehydrogenase activity
AKJ08_0860	COG2373	Large extracellular alpha-helical protein
AKJ08_0861	COG4953	penicillin-binding protein 1C
AKJ08_0865	COG3876	Protein conserved in bacteria
AKJ08_0866	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AKJ08_0868	COG0542	response to heat
AKJ08_0870	COG0823	Involved in the tonB-independent uptake of proteins
AKJ08_0872	COG3854	ATPases associated with a variety of cellular activities
AKJ08_0874	COG0742	ribosomal rna small subunit methyltransferase
AKJ08_0875	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AKJ08_0877	COG1278	Cold shock
AKJ08_0879	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AKJ08_0881	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AKJ08_0884	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AKJ08_0889	COG1546	Belongs to the CinA family
AKJ08_0889	COG1058	Belongs to the CinA family
AKJ08_0892	COG2986	histidine ammonia-lyase
AKJ08_0893	COG3830	Belongs to the UPF0237 family
AKJ08_0893	COG0560	Phosphoserine phosphatase
AKJ08_0895	COG1215	transferase activity, transferring glycosyl groups
AKJ08_0896	COG0210	DNA helicase
AKJ08_0898	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AKJ08_0900	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AKJ08_0901	COG1127	ABC transporter
AKJ08_0904	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AKJ08_0915	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AKJ08_0916	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AKJ08_0918	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AKJ08_0919	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AKJ08_0920	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AKJ08_0921	COG0072	phenylalanine-tRNA ligase activity
AKJ08_0923	COG0776	regulation of translation
AKJ08_0926	COG1994	Peptidase M50
AKJ08_0927	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
AKJ08_0928	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AKJ08_0929	COG1187	pseudouridine synthase activity
AKJ08_0933	COG0148	phosphopyruvate hydratase activity
AKJ08_0934	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AKJ08_0935	COG0517	IMP dehydrogenase activity
AKJ08_0937	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AKJ08_0939	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
AKJ08_0946	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AKJ08_0963	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AKJ08_0965	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
AKJ08_0967	COG0189	ligase activity
AKJ08_0972	COG0009	L-threonylcarbamoyladenylate synthase
AKJ08_0974	COG4974	Belongs to the 'phage' integrase family
AKJ08_0975	COG0534	Mate efflux family protein
AKJ08_0976	COG0017	Asparaginyl-tRNA synthetase
AKJ08_0977	COG0495	leucyl-tRNA aminoacylation
AKJ08_0979	COG0268	Binds directly to 16S ribosomal RNA
AKJ08_0980	COG3956	TIGRFAM MazG family protein
AKJ08_0984	COG1480	7TM receptor with intracellular HD hydrolase
AKJ08_0985	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AKJ08_0991	COG4591	ABC-type transport system involved in lipoprotein release permease component
AKJ08_0992	COG1136	(ABC) transporter
AKJ08_0993	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AKJ08_0993	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AKJ08_0995	COG0450	alkyl hydroperoxide reductase
AKJ08_0996	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AKJ08_0997	COG0316	Belongs to the HesB IscA family
AKJ08_0998	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AKJ08_1000	COG2095	MarC family integral membrane protein
AKJ08_1001	COG1132	(ABC) transporter
AKJ08_1004	COG0859	PFAM glycosyl transferase family 9
AKJ08_1005	COG1663	tetraacyldisaccharide 4'-kinase activity
AKJ08_1007	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AKJ08_1007	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
AKJ08_1009	COG2835	tetraacyldisaccharide 4'-kinase activity
AKJ08_1010	COG1561	YicC-like family, N-terminal region
AKJ08_1011	COG0194	GDP metabolic process
AKJ08_1012	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
AKJ08_1018	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AKJ08_1026	COG1570	exodeoxyribonuclease VII activity
AKJ08_1027	COG1722	exodeoxyribonuclease VII activity
AKJ08_1028	COG0745	RESPONSE REGULATOR receiver
AKJ08_1029	COG0142	geranyltranstransferase activity
AKJ08_1032	COG3177	Filamentation induced by cAMP protein fic
AKJ08_1036	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
AKJ08_1038	COG1543	Belongs to the glycosyl hydrolase 57 family
AKJ08_1043	COG0489	protein tyrosine kinase activity
AKJ08_1044	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AKJ08_1045	COG0391	Required for morphogenesis under gluconeogenic growth conditions
AKJ08_1046	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AKJ08_1053	COG1045	serine acetyltransferase
AKJ08_1059	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
AKJ08_1063	COG0443	Heat shock 70 kDa protein
AKJ08_1064	COG0484	heat shock protein binding
AKJ08_1069	COG0613	PHP domain protein
AKJ08_1070	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AKJ08_1071	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AKJ08_1073	COG0649	NAD binding
AKJ08_1074	COG1034	ATP synthesis coupled electron transport
AKJ08_1075	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
AKJ08_1076	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AKJ08_1078	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AKJ08_1079	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AKJ08_1085	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AKJ08_1088	COG0025	NhaP-type Na H and K H
AKJ08_1095	COG3344	reverse transcriptase
AKJ08_1096	COG1509	lysine 2,3-aminomutase activity
AKJ08_1110	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AKJ08_1111	COG2385	sporulation resulting in formation of a cellular spore
AKJ08_1117	COG1329	Transcriptional regulator
AKJ08_1118	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AKJ08_1118	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AKJ08_1121	COG0556	nucleotide-excision repair
AKJ08_1122	COG2234	aminopeptidase activity
AKJ08_1124	COG0322	excinuclease ABC activity
AKJ08_1130	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
AKJ08_1131	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
AKJ08_1132	COG1324	tolerance protein
AKJ08_1143	COG1489	DNA binding
AKJ08_1145	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AKJ08_1148	COG1725	Transcriptional regulator
AKJ08_1153	COG3415	Transposase
AKJ08_1153	COG2801	Transposase and inactivated derivatives
AKJ08_1165	COG0750	zinc metalloprotease
AKJ08_1169	COG1902	pentaerythritol trinitrate reductase activity
AKJ08_1182	COG0534	Mate efflux family protein
AKJ08_1186	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AKJ08_1190	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AKJ08_1198	COG1960	acyl-CoA dehydrogenase activity
AKJ08_1200	COG5000	phosphorelay sensor kinase activity
AKJ08_1200	COG5002	protein histidine kinase activity
AKJ08_1201	COG5006	permease, DMT superfamily
AKJ08_1203	COG0482	sulfurtransferase activity
AKJ08_1204	COG0183	Belongs to the thiolase family
AKJ08_1205	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AKJ08_1206	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AKJ08_1207	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AKJ08_1208	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AKJ08_1211	COG2259	Doxx family
AKJ08_1213	COG3220	belongs to the UPF0276 family
AKJ08_1216	COG1028	Short-chain dehydrogenase reductase Sdr
AKJ08_1221	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AKJ08_1230	COG0745	RESPONSE REGULATOR receiver
AKJ08_1231	COG1250	3-hydroxyacyl-CoA dehydrogenase
AKJ08_1233	COG1024	Enoyl-CoA hydratase
AKJ08_1234	COG1960	acyl-CoA dehydrogenase activity
AKJ08_1236	COG1960	acyl-CoA dehydrogenase activity
AKJ08_1238	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AKJ08_1238	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AKJ08_1243	COG0596	Alpha beta hydrolase
AKJ08_1245	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
AKJ08_1250	COG0577	efflux transmembrane transporter activity
AKJ08_1250	COG1136	(ABC) transporter
AKJ08_1251	COG1136	(ABC) transporter
AKJ08_1253	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AKJ08_1263	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
AKJ08_1264	COG0745	RESPONSE REGULATOR receiver
AKJ08_1266	COG2267	carboxylic ester hydrolase activity
AKJ08_1269	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AKJ08_1271	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AKJ08_1272	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
AKJ08_1273	COG0741	lytic transglycosylase activity
AKJ08_1275	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AKJ08_1276	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
AKJ08_1276	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AKJ08_1283	COG1494	fructose-1,6-bisphosphatase
AKJ08_1284	COG0616	signal peptide processing
AKJ08_1285	COG0489	protein tyrosine kinase activity
AKJ08_1288	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AKJ08_1294	COG0519	Catalyzes the synthesis of GMP from XMP
AKJ08_1294	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AKJ08_1299	COG1971	Probably functions as a manganese efflux pump
AKJ08_1305	COG3811	Belongs to the UPF0386 family
AKJ08_1313	COG0419	ATPase involved in DNA repair
AKJ08_1314	COG1201	RNA secondary structure unwinding
AKJ08_1315	COG1715	Restriction endonuclease
AKJ08_1334	COG0564	pseudouridine synthase activity
AKJ08_1336	COG3119	arylsulfatase activity
AKJ08_1342	COG1160	GTP binding
AKJ08_1345	COG0571	ribonuclease III activity
AKJ08_1347	COG1703	isobutyryl-CoA mutase activity
AKJ08_1348	COG1960	acyl-CoA dehydrogenase activity
AKJ08_1349	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AKJ08_1352	COG4771	TonB-dependent receptor
AKJ08_1354	COG3720	iron ion transport
AKJ08_1355	COG4558	Periplasmic binding protein
AKJ08_1356	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AKJ08_1357	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
AKJ08_1358	COG1024	Enoyl-CoA hydratase
AKJ08_1359	COG0515	serine threonine protein kinase
AKJ08_1360	COG5002	protein histidine kinase activity
AKJ08_1362	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AKJ08_1363	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AKJ08_1368	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AKJ08_1369	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AKJ08_1370	COG0277	FAD linked oxidase domain protein
AKJ08_1371	COG0302	gtp cyclohydrolase
AKJ08_1372	COG0720	synthase
AKJ08_1378	COG3411	Ferredoxin
AKJ08_1379	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AKJ08_1383	COG5492	domain, Protein
AKJ08_1383	COG4932	domain protein
AKJ08_1386	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AKJ08_1391	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AKJ08_1394	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AKJ08_1398	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
AKJ08_1399	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
AKJ08_1400	COG0045	succinate-CoA ligase (ADP-forming) activity
AKJ08_1402	COG1053	succinate dehydrogenase
AKJ08_1409	COG0505	Belongs to the CarA family
AKJ08_1411	COG0540	Belongs to the ATCase OTCase family
AKJ08_1412	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AKJ08_1415	COG0681	Belongs to the peptidase S26 family
AKJ08_1416	COG0481	GTPase activity
AKJ08_1423	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
AKJ08_1425	COG0616	signal peptide processing
AKJ08_1430	COG1196	nuclear chromosome segregation
AKJ08_1430	COG0745	RESPONSE REGULATOR receiver
AKJ08_1434	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
AKJ08_1435	COG0438	transferase activity, transferring glycosyl groups
AKJ08_1439	COG2322	membrane
AKJ08_1440	COG1999	signal sequence binding
AKJ08_1441	COG0109	protoheme IX farnesyltransferase activity
AKJ08_1443	COG0288	reversible hydration of carbon dioxide
AKJ08_1444	COG4608	Belongs to the ABC transporter superfamily
AKJ08_1446	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AKJ08_1447	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AKJ08_1448	COG0601	transmembrane transport
AKJ08_1458	COG2340	Cysteine-rich secretory protein family
AKJ08_1462	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AKJ08_1462	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AKJ08_1465	COG3706	GGDEF domain
AKJ08_1466	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
AKJ08_1469	COG0446	pyridine nucleotide-disulphide oxidoreductase
AKJ08_1470	COG0463	Glycosyl transferase, family 2
AKJ08_1480	COG0735	belongs to the Fur family
AKJ08_1486	COG0628	permease
AKJ08_1487	COG1028	Short-chain dehydrogenase reductase Sdr
AKJ08_1488	COG1181	Belongs to the D-alanine--D-alanine ligase family
AKJ08_1490	COG0113	porphobilinogen synthase activity
AKJ08_1492	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
AKJ08_1497	COG0151	Belongs to the GarS family
AKJ08_1499	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AKJ08_1502	COG0443	Heat shock 70 kDa protein
AKJ08_1516	COG1671	Belongs to the UPF0178 family
AKJ08_1519	COG0653	protein targeting
AKJ08_1524	COG0737	Belongs to the 5'-nucleotidase family
AKJ08_1526	COG1028	Short-chain dehydrogenase reductase Sdr
AKJ08_1539	COG1595	DNA-templated transcription, initiation
AKJ08_1542	COG1742	UPF0060 membrane protein
AKJ08_1543	COG1733	regulation of RNA biosynthetic process
AKJ08_1556	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AKJ08_1559	COG1335	isochorismatase
AKJ08_1563	COG1752	Esterase of the alpha-beta hydrolase superfamily
AKJ08_1577	COG0346	lactoylglutathione lyase activity
AKJ08_1580	COG0508	dehydrogenase complex catalyzes the overall conversion of
AKJ08_1581	COG0022	dehydrogenase e1 component
AKJ08_1582	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AKJ08_1585	COG0181	hydroxymethylbilane synthase activity
AKJ08_1586	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AKJ08_1587	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AKJ08_1589	COG3118	belongs to the thioredoxin family
AKJ08_1590	COG0772	Belongs to the SEDS family
AKJ08_1591	COG0768	penicillin binding
AKJ08_1595	COG0745	RESPONSE REGULATOR receiver
AKJ08_1595	COG3706	GGDEF domain
AKJ08_1596	COG0424	maF-like protein
AKJ08_1599	COG0737	Belongs to the 5'-nucleotidase family
AKJ08_1608	COG4464	protein tyrosine phosphatase activity
AKJ08_1609	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
AKJ08_1613	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AKJ08_1613	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AKJ08_1617	COG0217	transcriptional regulatory protein
AKJ08_1621	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AKJ08_1622	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AKJ08_1622	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AKJ08_1625	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AKJ08_1625	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AKJ08_1626	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AKJ08_1628	COG0698	ribose 5-phosphate isomerase
AKJ08_1629	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AKJ08_1630	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AKJ08_1631	COG1028	Short-chain dehydrogenase reductase Sdr
AKJ08_1632	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AKJ08_1634	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AKJ08_1638	COG0529	Catalyzes the synthesis of activated sulfate
AKJ08_1638	COG2046	Belongs to the sulfate adenylyltransferase family
AKJ08_1639	COG3189	MarR family transcriptional regulator
AKJ08_1640	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
AKJ08_1641	COG0488	(ABC) transporter
AKJ08_1642	COG2814	Major facilitator Superfamily
AKJ08_1646	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AKJ08_1654	COG0705	Rhomboid family
AKJ08_1654	COG0457	Tetratricopeptide repeat
AKJ08_1656	COG0668	transmembrane transport
AKJ08_1657	COG0564	pseudouridine synthase activity
AKJ08_1659	COG0484	heat shock protein binding
AKJ08_1660	COG0455	bacterial-type flagellum organization
AKJ08_1662	COG1921	L-seryl-tRNASec selenium transferase activity
AKJ08_1663	COG0741	lytic transglycosylase activity
AKJ08_1664	COG3852	Histidine kinase
AKJ08_1665	COG2204	response regulator
AKJ08_1666	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AKJ08_1667	COG0792	nuclease activity
AKJ08_1669	COG0335	large ribosomal subunit rRNA binding
AKJ08_1673	COG0228	four-way junction DNA binding
AKJ08_1677	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AKJ08_1683	COG0564	pseudouridine synthase activity
AKJ08_1684	COG0612	Peptidase, M16
AKJ08_1685	COG0612	Peptidase, M16
AKJ08_1687	COG1858	cytochrome C peroxidase
AKJ08_1691	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
AKJ08_1693	COG0493	'glutamate synthase
AKJ08_1693	COG0543	2 iron, 2 sulfur cluster binding
AKJ08_1705	COG2204	response regulator
AKJ08_1720	COG2826	transposase and inactivated derivatives, IS30 family
AKJ08_1725	COG2814	Major facilitator Superfamily
AKJ08_1728	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AKJ08_1730	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AKJ08_1730	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AKJ08_1731	COG0180	Tryptophanyl-tRNA synthetase
AKJ08_1733	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
AKJ08_1736	COG2255	four-way junction helicase activity
AKJ08_1739	COG0632	four-way junction helicase activity
AKJ08_1740	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AKJ08_1741	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AKJ08_1744	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AKJ08_1747	COG1214	PFAM Peptidase M22, glycoprotease
AKJ08_1748	COG0750	zinc metalloprotease
AKJ08_1750	COG4589	Belongs to the CDS family
AKJ08_1751	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AKJ08_1755	COG1484	DNA-dependent DNA replication
AKJ08_1758	COG1131	(ABC) transporter
AKJ08_1765	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AKJ08_1766	COG0459	protein refolding
AKJ08_1768	COG0459	protein refolding
AKJ08_1769	COG0459	protein refolding
AKJ08_1773	COG1196	nuclear chromosome segregation
AKJ08_1778	COG2204	response regulator
AKJ08_1780	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AKJ08_1782	COG1755	Isoprenylcysteine carboxyl methyltransferase
AKJ08_1784	COG0318	PFAM AMP-dependent synthetase and ligase
AKJ08_1787	COG1595	DNA-templated transcription, initiation
AKJ08_1788	COG3872	metal-dependent enzyme
AKJ08_1789	COG0254	rRNA binding
AKJ08_1790	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
AKJ08_1792	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AKJ08_1793	COG1254	Belongs to the acylphosphatase family
AKJ08_1794	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AKJ08_1796	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AKJ08_1796	COG4651	solute:proton antiporter activity
AKJ08_1797	COG0539	negative regulation of cytoplasmic translation
AKJ08_1799	COG0739	heme binding
AKJ08_1801	COG1166	arginine decarboxylase activity
AKJ08_1802	COG0443	Heat shock 70 kDa protein
AKJ08_1808	COG1012	belongs to the aldehyde dehydrogenase family
AKJ08_1809	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AKJ08_1817	COG1090	epimerase
AKJ08_1819	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AKJ08_1824	COG1335	isochorismatase
AKJ08_1826	COG1294	oxidase, subunit
AKJ08_1827	COG1271	oxidase subunit
AKJ08_1828	COG0534	Mate efflux family protein
AKJ08_1829	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AKJ08_1836	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AKJ08_1843	COG0436	Aminotransferase
AKJ08_1844	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AKJ08_1845	COG3494	Protein of unknown function (DUF1009)
AKJ08_1847	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AKJ08_1848	COG0505	Belongs to the CarA family
AKJ08_1854	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AKJ08_1858	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AKJ08_1864	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AKJ08_1878	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AKJ08_1880	COG0183	Belongs to the thiolase family
AKJ08_1882	COG0473	3-isopropylmalate dehydrogenase activity
AKJ08_1884	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AKJ08_1886	COG0805	protein transport
AKJ08_1887	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AKJ08_1892	COG2189	Belongs to the N(4) N(6)-methyltransferase family
AKJ08_1893	COG0564	pseudouridine synthase activity
AKJ08_1896	COG0427	acetyl-CoA hydrolase
AKJ08_1903	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AKJ08_1906	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AKJ08_1910	COG0456	acetyltransferase
AKJ08_1913	COG1450	Type ii and iii secretion system protein
AKJ08_1917	COG0751	glycine-tRNA ligase activity
AKJ08_1918	COG0752	glycyl-tRNA synthetase alpha subunit
AKJ08_1921	COG0539	negative regulation of cytoplasmic translation
AKJ08_1921	COG2183	response to ionizing radiation
AKJ08_1922	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AKJ08_1923	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AKJ08_1924	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AKJ08_1925	COG0825	malonyl-CoA metabolic process
AKJ08_1927	COG3973	AAA domain
AKJ08_1928	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AKJ08_1929	COG0124	histidyl-tRNA synthetase
AKJ08_1930	COG0688	phosphatidylethanolamine metabolic process
AKJ08_1936	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AKJ08_1938	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AKJ08_1939	COG0631	protein serine/threonine phosphatase activity
AKJ08_1948	COG0203	ribosomal protein L17
AKJ08_1951	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AKJ08_1952	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AKJ08_1953	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AKJ08_1955	COG0563	adenylate kinase activity
AKJ08_1956	COG0201	protein transport
AKJ08_1957	COG0200	Binds to the 23S rRNA
AKJ08_1958	COG1841	ribosomal large subunit assembly
AKJ08_1959	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AKJ08_1960	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AKJ08_1961	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AKJ08_1962	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AKJ08_1963	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AKJ08_1964	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AKJ08_1965	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AKJ08_1966	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AKJ08_1967	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AKJ08_1968	COG0255	Belongs to the universal ribosomal protein uL29 family
AKJ08_1969	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AKJ08_1974	COG0089	rRNA binding
AKJ08_1975	COG0088	Forms part of the polypeptide exit tunnel
AKJ08_1976	COG0051	transcription antitermination factor activity, RNA binding
AKJ08_1977	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AKJ08_1978	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AKJ08_1980	COG0049	tRNA binding
AKJ08_1989	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AKJ08_1993	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AKJ08_1994	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AKJ08_1999	COG1228	amidohydrolase
AKJ08_2005	COG2201	protein-glutamate methylesterase activity
AKJ08_2007	COG2201	protein-glutamate methylesterase activity
AKJ08_2008	COG0500	methyltransferase
AKJ08_2009	COG3844	kynureninase activity
AKJ08_2010	COG3483	tryptophan 2,3-dioxygenase activity
AKJ08_2011	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
AKJ08_2012	COG0802	atpase or kinase
AKJ08_2013	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AKJ08_2013	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AKJ08_2014	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
AKJ08_2016	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AKJ08_2017	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AKJ08_2019	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
AKJ08_2020	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AKJ08_2021	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AKJ08_2022	COG0037	tRNA processing
AKJ08_2025	COG3246	L-lysine catabolic process to acetate
AKJ08_2026	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AKJ08_2030	COG1607	acyl-coa hydrolase
AKJ08_2038	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AKJ08_2039	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
AKJ08_2044	COG0604	alcohol dehydrogenase
AKJ08_2045	COG0330	HflC and HflK could
AKJ08_2046	COG0616	signal peptide processing
AKJ08_2047	COG1573	uracil-dna glycosylase
AKJ08_2049	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AKJ08_2054	COG0686	Belongs to the AlaDH PNT family
AKJ08_2055	COG1595	DNA-templated transcription, initiation
AKJ08_2058	COG0745	RESPONSE REGULATOR receiver
AKJ08_2061	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
AKJ08_2062	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
AKJ08_2062	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
AKJ08_2065	COG0525	valine-tRNA ligase activity
AKJ08_2066	COG0784	Response regulator, receiver
AKJ08_2068	COG2010	Cytochrome c
AKJ08_2068	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AKJ08_2069	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AKJ08_2070	COG0085	RNA polymerase activity
AKJ08_2071	COG0222	ribosome binding
AKJ08_2072	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AKJ08_2073	COG0081	regulation of translation
AKJ08_2074	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AKJ08_2077	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AKJ08_2078	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AKJ08_2079	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AKJ08_2081	COG0189	ligase activity
AKJ08_2085	COG0443	Heat shock 70 kDa protein
AKJ08_2091	COG0110	maltose O-acetyltransferase activity
AKJ08_2104	COG0022	dehydrogenase e1 component
AKJ08_2106	COG1183	phosphatidylcholine synthase activity
AKJ08_2112	COG5002	protein histidine kinase activity
AKJ08_2114	COG1193	negative regulation of DNA recombination
AKJ08_2116	COG0557	exoribonuclease II activity
AKJ08_2118	COG0789	Transcriptional regulator
AKJ08_2120	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AKJ08_2122	COG0022	dehydrogenase e1 component
AKJ08_2123	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AKJ08_2124	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AKJ08_2126	COG1012	belongs to the aldehyde dehydrogenase family
AKJ08_2129	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AKJ08_2132	COG0101	tRNA pseudouridine synthase activity
AKJ08_2134	COG1606	tRNA processing
AKJ08_2135	COG2046	Belongs to the sulfate adenylyltransferase family
AKJ08_2135	COG0529	Catalyzes the synthesis of activated sulfate
AKJ08_2139	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AKJ08_2140	COG4585	Histidine kinase
AKJ08_2141	COG2197	response regulator
AKJ08_2145	COG2086	electron transfer activity
AKJ08_2146	COG1960	acyl-CoA dehydrogenase activity
AKJ08_2147	COG1309	transcriptional regulator
AKJ08_2156	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AKJ08_2157	COG0179	Fumarylacetoacetate (FAA) hydrolase
AKJ08_2158	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AKJ08_2159	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AKJ08_2162	COG2715	membrane protein required for spore maturation
AKJ08_2163	COG0700	Nucleoside recognition
AKJ08_2164	COG2894	cell division
AKJ08_2172	COG0785	Cytochrome C biogenesis protein
AKJ08_2174	COG1595	DNA-templated transcription, initiation
AKJ08_2176	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AKJ08_2177	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AKJ08_2178	COG0242	peptide deformylase activity
AKJ08_2179	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AKJ08_2183	COG1183	phosphatidylcholine synthase activity
AKJ08_2184	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
AKJ08_2185	COG1058	Belongs to the CinA family
AKJ08_2185	COG1546	Belongs to the CinA family
AKJ08_2188	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
AKJ08_2189	COG1309	transcriptional regulator
AKJ08_2192	COG0606	chelatase, subunit chli
AKJ08_2194	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AKJ08_2195	COG1596	polysaccharide export
AKJ08_2198	COG1100	Small GTP-binding protein
AKJ08_2200	COG1428	Deoxynucleoside kinase
AKJ08_2202	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AKJ08_2203	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AKJ08_2204	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AKJ08_2205	COG0037	tRNA processing
AKJ08_2206	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AKJ08_2207	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AKJ08_2212	COG0631	protein serine/threonine phosphatase activity
AKJ08_2213	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AKJ08_2215	COG1215	transferase activity, transferring glycosyl groups
AKJ08_2223	COG0626	cystathionine gamma-synthase activity
AKJ08_2225	COG1131	(ABC) transporter
AKJ08_2230	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
AKJ08_2232	COG0673	inositol 2-dehydrogenase activity
AKJ08_2234	COG0714	Associated with various cellular activities
AKJ08_2235	COG0515	serine threonine protein kinase
AKJ08_2238	COG1024	Enoyl-CoA hydratase
AKJ08_2239	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
AKJ08_2240	COG0439	Biotin carboxylase
AKJ08_2241	COG1278	Cold shock
AKJ08_2242	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AKJ08_2247	COG1181	Belongs to the D-alanine--D-alanine ligase family
AKJ08_2248	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AKJ08_2250	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AKJ08_2251	COG0772	Belongs to the SEDS family
AKJ08_2252	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AKJ08_2253	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AKJ08_2254	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AKJ08_2255	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AKJ08_2257	COG3116	cell division
AKJ08_2260	COG2001	Belongs to the MraZ family
AKJ08_2261	COG0438	transferase activity, transferring glycosyl groups
AKJ08_2264	COG0596	Alpha beta hydrolase
AKJ08_2266	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
AKJ08_2268	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
AKJ08_2274	COG0174	glutamine synthetase
AKJ08_2275	COG0519	Catalyzes the synthesis of GMP from XMP
AKJ08_2276	COG1012	belongs to the aldehyde dehydrogenase family
AKJ08_2284	COG2975	iron-sulfur cluster assembly
AKJ08_2285	COG0633	Ferredoxin
AKJ08_2286	COG0443	Heat shock 70 kDa protein
AKJ08_2288	COG0316	Belongs to the HesB IscA family
AKJ08_2289	COG0822	iron-sulfur transferase activity
AKJ08_2290	COG1104	cysteine desulfurase activity
AKJ08_2291	COG4232	protein-disulfide reductase activity
AKJ08_2292	COG0515	serine threonine protein kinase
AKJ08_2300	COG4191	Histidine kinase
AKJ08_2301	COG0612	Peptidase, M16
AKJ08_2306	COG0793	Belongs to the peptidase S41A family
AKJ08_2309	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
AKJ08_2310	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AKJ08_2311	COG2088	sporulation resulting in formation of a cellular spore
AKJ08_2312	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AKJ08_2315	COG0360	Binds together with S18 to 16S ribosomal RNA
AKJ08_2316	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AKJ08_2317	COG0359	binds to the 23S rRNA
AKJ08_2318	COG0305	Participates in initiation and elongation during chromosome replication
AKJ08_2324	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
AKJ08_2325	COG0352	thiamine-phosphate diphosphorylase activity
AKJ08_2330	COG0463	Glycosyl transferase, family 2
AKJ08_2333	COG0542	response to heat
AKJ08_2338	COG0514	ATP-dependent DNA helicase (RecQ)
AKJ08_2338	COG0514	ATP-dependent DNA helicase (RecQ)
AKJ08_2339	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AKJ08_2340	COG2890	protein-(glutamine-N5) methyltransferase activity
AKJ08_2341	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AKJ08_2346	COG2827	Endonuclease containing a URI domain
AKJ08_2349	COG4269	membrane
AKJ08_2350	COG0501	Belongs to the peptidase M48B family
AKJ08_2354	COG2226	methyltransferase
AKJ08_2367	COG2132	Multicopper oxidase
AKJ08_2368	COG0789	Transcriptional regulator
AKJ08_2369	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
AKJ08_2370	COG1028	Short-chain dehydrogenase reductase Sdr
AKJ08_2372	COG1360	Flagellar Motor Protein
AKJ08_2376	COG3706	GGDEF domain
AKJ08_2377	COG3706	GGDEF domain
AKJ08_2382	COG4294	response to UV
AKJ08_2383	COG5492	domain, Protein
AKJ08_2383	COG4932	domain protein
AKJ08_2390	COG0546	phosphoglycolate phosphatase activity
AKJ08_2394	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AKJ08_2397	COG4106	trans-aconitate 2-methyltransferase activity
AKJ08_2398	COG2267	carboxylic ester hydrolase activity
AKJ08_2399	COG0156	8-amino-7-oxononanoate synthase activity
AKJ08_2401	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AKJ08_2403	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AKJ08_2404	COG5002	protein histidine kinase activity
AKJ08_2405	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AKJ08_2407	COG2239	Acts as a magnesium transporter
AKJ08_2409	COG0420	3'-5' exonuclease activity
AKJ08_2410	COG2183	response to ionizing radiation
AKJ08_2411	COG0668	transmembrane transport
AKJ08_2412	COG2070	2-Nitropropane dioxygenase
AKJ08_2412	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AKJ08_2414	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AKJ08_2415	COG0596	Alpha beta hydrolase
AKJ08_2416	COG0318	PFAM AMP-dependent synthetase and ligase
AKJ08_2417	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AKJ08_2420	COG3263	regulation of cellular component size
AKJ08_2426	COG0513	Belongs to the DEAD box helicase family
AKJ08_2427	COG0708	Exodeoxyribonuclease III
AKJ08_2430	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AKJ08_2440	COG1131	(ABC) transporter
AKJ08_2441	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AKJ08_2445	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AKJ08_2446	COG5492	domain, Protein
AKJ08_2446	COG4932	domain protein
AKJ08_2447	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
AKJ08_2456	COG0616	signal peptide processing
AKJ08_2460	COG5002	protein histidine kinase activity
AKJ08_2462	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
AKJ08_2463	COG0784	Response regulator, receiver
AKJ08_2463	COG2205	protein histidine kinase activity
AKJ08_2463	COG5002	protein histidine kinase activity
AKJ08_2465	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AKJ08_2466	COG0573	inorganic phosphate transmembrane transporter activity
AKJ08_2467	COG0581	inorganic phosphate transmembrane transporter activity
AKJ08_2468	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AKJ08_2474	COG0583	DNA-binding transcription factor activity
AKJ08_2481	COG0656	L-ascorbic acid biosynthetic process
AKJ08_2486	COG0811	peptide transport
AKJ08_2491	COG0745	RESPONSE REGULATOR receiver
AKJ08_2496	COG0811	peptide transport
AKJ08_2520	COG1418	mRNA catabolic process
AKJ08_2521	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AKJ08_2522	COG2264	protein methyltransferase activity
AKJ08_2523	COG0612	Peptidase, M16
AKJ08_2527	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
AKJ08_2528	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AKJ08_2529	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AKJ08_2530	COG2197	response regulator
AKJ08_2534	COG0492	ferredoxin-NADP+ reductase activity
AKJ08_2535	COG2003	Belongs to the UPF0758 family
AKJ08_2541	COG0629	single-stranded DNA binding
AKJ08_2542	COG2027	D-alanyl-D-alanine carboxypeptidase
AKJ08_2543	COG4166	transmembrane transport
AKJ08_2544	COG0601	transmembrane transport
AKJ08_2545	COG1295	ribonuclease BN
AKJ08_2547	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
AKJ08_2548	COG1278	Cold shock
AKJ08_2549	COG2840	Smr protein MutS2
AKJ08_2550	COG3483	tryptophan 2,3-dioxygenase activity
AKJ08_2559	COG2267	carboxylic ester hydrolase activity
AKJ08_2561	COG1028	Short-chain dehydrogenase reductase Sdr
AKJ08_2567	COG1846	Transcriptional regulator
AKJ08_2568	COG1136	(ABC) transporter
AKJ08_2581	COG0346	lactoylglutathione lyase activity
AKJ08_2582	COG0300	oxidoreductase activity
AKJ08_2583	COG1252	NADH dehydrogenase
AKJ08_2584	COG0352	thiamine-phosphate diphosphorylase activity
AKJ08_2584	COG0351	phosphomethylpyrimidine kinase
AKJ08_2585	COG1028	Short-chain dehydrogenase reductase Sdr
AKJ08_2587	COG0617	tRNA 3'-terminal CCA addition
AKJ08_2588	COG0617	tRNA 3'-terminal CCA addition
AKJ08_2590	COG3118	belongs to the thioredoxin family
AKJ08_2604	COG1192	Involved in chromosome partitioning
AKJ08_2609	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AKJ08_2610	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AKJ08_2611	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AKJ08_2612	COG3716	PTS system mannose fructose sorbose family IID component
AKJ08_2614	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AKJ08_2615	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AKJ08_2615	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
AKJ08_2616	COG1660	Displays ATPase and GTPase activities
AKJ08_2617	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
AKJ08_2618	COG0745	RESPONSE REGULATOR receiver
AKJ08_2619	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AKJ08_2624	COG1560	Kdo2-lipid A biosynthetic process
AKJ08_2625	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
AKJ08_2628	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
AKJ08_2637	COG1024	Enoyl-CoA hydratase
AKJ08_2638	COG0251	oxidation-reduction process
AKJ08_2647	COG1160	GTP binding
AKJ08_2651	COG1960	acyl-CoA dehydrogenase activity
AKJ08_2657	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AKJ08_2660	COG1040	competence protein
AKJ08_2662	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
AKJ08_2663	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
AKJ08_2664	COG0799	negative regulation of ribosome biogenesis
AKJ08_2666	COG0429	hydrolase of the alpha beta-hydrolase fold
AKJ08_2668	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AKJ08_2672	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
AKJ08_2673	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AKJ08_2674	COG4221	oxidoreductase activity
AKJ08_2675	COG2259	Doxx family
AKJ08_2676	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
AKJ08_2679	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AKJ08_2684	COG4206	TonB-dependent receptor
AKJ08_2687	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AKJ08_2691	COG1120	ATPase activity
AKJ08_2692	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
AKJ08_2694	COG1490	D-aminoacyl-tRNA deacylase activity
AKJ08_2696	COG3138	arginine N-succinyltransferase
AKJ08_2700	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AKJ08_2701	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AKJ08_2705	COG1331	Highly conserved protein containing a thioredoxin domain
AKJ08_2708	COG2204	response regulator
AKJ08_2709	COG3961	Belongs to the TPP enzyme family
AKJ08_2711	COG0729	surface antigen
AKJ08_2723	COG1940	carbohydrate kinase activity
AKJ08_2730	COG0745	RESPONSE REGULATOR receiver
AKJ08_2745	COG0494	nUDIX hydrolase
AKJ08_2746	COG1968	undecaprenyl-diphosphatase activity
AKJ08_2747	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
AKJ08_2748	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AKJ08_2749	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AKJ08_2751	COG1024	Enoyl-CoA hydratase
AKJ08_2751	COG1250	3-hydroxyacyl-CoA dehydrogenase
AKJ08_2762	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
AKJ08_2763	COG3387	PFAM Glycoside hydrolase 15-related
AKJ08_2765	COG3158	transport of potassium into the cell
AKJ08_2766	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AKJ08_2768	COG0523	cobalamin synthesis protein
AKJ08_2770	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AKJ08_2771	COG1309	transcriptional regulator
AKJ08_2772	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
AKJ08_2776	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AKJ08_2777	COG1253	flavin adenine dinucleotide binding
AKJ08_2782	COG3104	oligopeptide transport
AKJ08_2783	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AKJ08_2795	COG2201	protein-glutamate methylesterase activity
AKJ08_2797	COG0745	RESPONSE REGULATOR receiver
AKJ08_2801	COG1234	tRNA 3'-trailer cleavage
AKJ08_2802	COG2826	transposase and inactivated derivatives, IS30 family
AKJ08_2805	COG0488	(ABC) transporter
AKJ08_2807	COG2267	carboxylic ester hydrolase activity
AKJ08_2811	COG1994	Peptidase M50
AKJ08_2813	COG0564	pseudouridine synthase activity
AKJ08_2815	COG0842	Transport permease protein
AKJ08_2816	COG1131	(ABC) transporter
AKJ08_2818	COG0372	Belongs to the citrate synthase family
AKJ08_2819	COG5002	protein histidine kinase activity
AKJ08_2820	COG4413	Urea transporter
AKJ08_2821	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
AKJ08_2822	COG0830	nickel cation binding
AKJ08_2823	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
AKJ08_2824	COG0804	urea catabolic process
AKJ08_2825	COG0832	Belongs to the urease beta subunit family
AKJ08_2826	COG0831	urea catabolic process
AKJ08_2827	COG0829	nickel cation binding
AKJ08_2828	COG3619	membrane
AKJ08_2836	COG0730	response to heat
AKJ08_2837	COG3453	Protein conserved in bacteria
AKJ08_2837	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AKJ08_2838	COG2204	response regulator
AKJ08_2839	COG2084	Dehydrogenase
AKJ08_2847	COG0450	alkyl hydroperoxide reductase
AKJ08_2848	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AKJ08_2851	COG2867	negative regulation of translational initiation
AKJ08_2856	COG0023	Translation Initiation Factor
AKJ08_2858	COG2207	Transcriptional regulator
AKJ08_2860	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AKJ08_2861	COG0584	glycerophosphoryl diester phosphodiesterase
AKJ08_2870	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
AKJ08_2874	COG0745	RESPONSE REGULATOR receiver
AKJ08_2875	COG2205	protein histidine kinase activity
AKJ08_2876	COG1619	proteins homologs of microcin C7 resistance protein MccF
AKJ08_2877	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AKJ08_2878	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AKJ08_2883	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AKJ08_2888	COG2967	ApaG domain
AKJ08_2890	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
AKJ08_2895	COG2826	transposase and inactivated derivatives, IS30 family
AKJ08_2896	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AKJ08_2899	COG2094	Belongs to the DNA glycosylase MPG family
AKJ08_2902	COG0728	peptidoglycan biosynthetic process
AKJ08_2903	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AKJ08_2905	COG2205	protein histidine kinase activity
AKJ08_2906	COG0745	RESPONSE REGULATOR receiver
AKJ08_2908	COG0626	cystathionine gamma-synthase activity
AKJ08_2912	COG1965	Belongs to the frataxin family
AKJ08_2913	COG1612	heme a metabolic process
AKJ08_2913	COG0109	protoheme IX farnesyltransferase activity
AKJ08_2917	COG2877	3-deoxy-8-phosphooctulonate synthase activity
AKJ08_2918	COG0504	CTP synthase activity
AKJ08_2921	COG0667	Aldo Keto reductase
AKJ08_2924	COG1393	Belongs to the ArsC family
AKJ08_2926	COG4106	trans-aconitate 2-methyltransferase activity
AKJ08_2932	COG1063	alcohol dehydrogenase
AKJ08_2936	COG2814	Major facilitator Superfamily
AKJ08_2944	COG4941	Belongs to the sigma-70 factor family
AKJ08_2947	COG1247	-acetyltransferase
AKJ08_2949	COG0640	Transcriptional regulator
AKJ08_2952	COG2130	NADP-dependent
AKJ08_2953	COG0024	Methionine aminopeptidase
AKJ08_2960	COG2059	Chromate
AKJ08_2962	COG2085	NADP oxidoreductase coenzyme F420-dependent
AKJ08_2971	COG1012	belongs to the aldehyde dehydrogenase family
AKJ08_2974	COG0456	acetyltransferase
AKJ08_2974	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
AKJ08_2978	COG1132	(ABC) transporter
AKJ08_2979	COG1132	(ABC) transporter
AKJ08_2980	COG0590	tRNA wobble adenosine to inosine editing
AKJ08_2987	COG2169	Transcriptional regulator
AKJ08_2987	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AKJ08_2992	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AKJ08_2997	COG3795	YCII-related domain
AKJ08_2998	COG2824	Alkylphosphonate utilization operon protein PhnA
AKJ08_3004	COG1741	Belongs to the pirin family
AKJ08_3011	COG0114	fumarate hydratase activity
AKJ08_3017	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AKJ08_3033	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AKJ08_3037	COG4191	Histidine kinase
AKJ08_3040	COG1595	DNA-templated transcription, initiation
AKJ08_3041	COG5507	3-demethylubiquinone-9 3-methyltransferase
AKJ08_3045	COG1595	DNA-templated transcription, initiation
AKJ08_3051	COG1881	PFAM PEBP family protein
AKJ08_3052	COG2826	transposase and inactivated derivatives, IS30 family
AKJ08_3056	COG2826	transposase and inactivated derivatives, IS30 family
AKJ08_3061	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AKJ08_3077	COG0625	glutathione transferase activity
AKJ08_3078	COG1309	transcriptional regulator
AKJ08_3079	COG1028	Short-chain dehydrogenase reductase Sdr
AKJ08_3081	COG4585	Histidine kinase
AKJ08_3082	COG2197	response regulator
AKJ08_3086	COG1741	Belongs to the pirin family
AKJ08_3092	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AKJ08_3093	COG0798	PFAM Bile acid sodium symporter
AKJ08_3096	COG0431	NADPH-dependent FMN reductase
AKJ08_3097	COG1741	Belongs to the pirin family
AKJ08_3098	COG0583	DNA-binding transcription factor activity
AKJ08_3103	COG1028	Short-chain dehydrogenase reductase Sdr
AKJ08_3104	COG0596	Alpha beta hydrolase
AKJ08_3106	COG0598	Magnesium transport protein CorA
AKJ08_3109	COG2818	Glycosylase
AKJ08_3116	COG2226	methyltransferase
AKJ08_3117	COG3177	Filamentation induced by cAMP protein fic
AKJ08_3136	COG0640	Transcriptional regulator
AKJ08_3137	COG0640	Transcriptional regulator
AKJ08_3139	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
AKJ08_3140	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
AKJ08_3141	COG1984	allophanate hydrolase subunit 2
AKJ08_3159	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AKJ08_3161	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AKJ08_3163	COG1024	Enoyl-CoA hydratase
AKJ08_3166	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AKJ08_3167	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AKJ08_3168	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AKJ08_3169	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AKJ08_3170	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AKJ08_3171	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AKJ08_3173	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AKJ08_3173	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AKJ08_3175	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AKJ08_3176	COG0745	RESPONSE REGULATOR receiver
AKJ08_3182	COG2363	Small membrane protein
AKJ08_3185	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AKJ08_3188	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
AKJ08_3190	COG5002	protein histidine kinase activity
AKJ08_3193	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AKJ08_3194	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AKJ08_3201	COG0437	4 iron, 4 sulfur cluster binding
AKJ08_3204	COG1643	Atp-dependent helicase
AKJ08_3207	COG1420	regulation of RNA biosynthetic process
AKJ08_3208	COG0531	amino acid
AKJ08_3209	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
AKJ08_3211	COG0730	response to heat
AKJ08_3212	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AKJ08_3213	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AKJ08_3214	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AKJ08_3215	COG0569	domain protein
AKJ08_3215	COG0189	ligase activity
AKJ08_3219	COG0247	lactate metabolic process
AKJ08_3219	COG2181	nitrate reductase activity
AKJ08_3229	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AKJ08_3230	COG0592	DNA-directed DNA polymerase activity
AKJ08_3232	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AKJ08_3234	COG0230	Belongs to the bacterial ribosomal protein bL34 family
AKJ08_3235	COG0594	ribonuclease P activity
AKJ08_3236	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AKJ08_3237	COG0706	membrane insertase activity
AKJ08_3242	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
AKJ08_3246	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AKJ08_3247	COG0357	Ribosomal RNA small subunit methyltransferase G
AKJ08_3249	COG1192	Involved in chromosome partitioning
AKJ08_3250	COG1475	DNA binding
AKJ08_3252	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AKJ08_3253	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AKJ08_3254	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AKJ08_3255	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AKJ08_3259	COG0402	S-adenosylhomocysteine deaminase activity
AKJ08_3265	COG1902	pentaerythritol trinitrate reductase activity
AKJ08_3265	COG0446	pyridine nucleotide-disulphide oxidoreductase
AKJ08_3266	COG0386	Belongs to the glutathione peroxidase family
AKJ08_3272	COG0733	neurotransmitter:sodium symporter activity
AKJ08_3273	COG2759	Belongs to the formate--tetrahydrofolate ligase family
AKJ08_3274	COG2855	membrane
AKJ08_3277	COG0583	DNA-binding transcription factor activity
AKJ08_3278	COG0517	IMP dehydrogenase activity
AKJ08_3279	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AKJ08_3285	COG0300	oxidoreductase activity
AKJ08_3286	COG0475	glutathione-regulated potassium exporter activity
AKJ08_3288	COG2314	TM2 domain
AKJ08_3289	COG3590	peptidase
AKJ08_3292	COG1704	LemA family
AKJ08_3296	COG2204	response regulator
AKJ08_3297	COG5002	protein histidine kinase activity
AKJ08_3304	COG0347	Belongs to the P(II) protein family
AKJ08_3305	COG3852	Histidine kinase
AKJ08_3309	COG0356	it plays a direct role in the translocation of protons across the membrane
AKJ08_3310	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AKJ08_3311	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AKJ08_3312	COG0012	GTP binding
AKJ08_3314	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
AKJ08_3315	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AKJ08_3316	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AKJ08_3317	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AKJ08_3324	COG1045	serine acetyltransferase
AKJ08_3325	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AKJ08_3333	COG2962	Rard protein
AKJ08_3334	COG1047	Peptidyl-prolyl cis-trans
AKJ08_3340	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AKJ08_3341	COG0443	Heat shock 70 kDa protein
AKJ08_3342	COG0284	orotidine-5'-phosphate decarboxylase activity
AKJ08_3343	COG0484	heat shock protein binding
AKJ08_3356	COG0443	Heat shock 70 kDa protein
AKJ08_3357	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AKJ08_3362	COG0667	Aldo Keto reductase
AKJ08_3365	COG1741	Belongs to the pirin family
AKJ08_3367	COG2346	COG2346, Truncated hemoglobins
AKJ08_3369	COG2217	Heavy metal translocating P-type atpase
AKJ08_3371	COG3278	Belongs to the heme-copper respiratory oxidase family
AKJ08_3373	COG2010	Cytochrome c
AKJ08_3376	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AKJ08_3379	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
AKJ08_3380	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AKJ08_3386	COG0739	heme binding
AKJ08_3390	COG4786	Flagellar basal body rod
AKJ08_3391	COG4786	Flagellar basal body rod
AKJ08_3393	COG1191	sigma factor activity
AKJ08_3394	COG0455	bacterial-type flagellum organization
AKJ08_3396	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AKJ08_3397	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AKJ08_3398	COG1684	flagellar biosynthetic protein fliR
AKJ08_3399	COG1987	bacterial-type flagellum assembly
AKJ08_3406	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
AKJ08_3409	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
AKJ08_3414	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AKJ08_3416	COG1677	Flagellar hook-basal body complex protein FliE
AKJ08_3417	COG1558	bacterial-type flagellum-dependent cell motility
AKJ08_3418	COG1815	bacterial-type flagellum-dependent cell motility
AKJ08_3420	COG2204	response regulator
AKJ08_3421	COG5002	protein histidine kinase activity
AKJ08_3426	COG1199	ATP-dependent helicase activity
AKJ08_3428	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AKJ08_3429	COG1100	Small GTP-binding protein
AKJ08_3430	COG0784	Response regulator, receiver
AKJ08_3430	COG2205	protein histidine kinase activity
AKJ08_3430	COG5002	protein histidine kinase activity
AKJ08_3431	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
AKJ08_3432	COG0840	transmembrane signaling receptor activity
AKJ08_3434	COG0643	Histidine kinase
AKJ08_3434	COG2198	Histidine kinase
AKJ08_3435	COG1691	(AIR) carboxylase
AKJ08_3436	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
AKJ08_3437	COG4191	Histidine kinase
AKJ08_3437	COG2205	protein histidine kinase activity
AKJ08_3437	COG0745	RESPONSE REGULATOR receiver
AKJ08_3442	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
AKJ08_3445	COG0179	Fumarylacetoacetate (FAA) hydrolase
AKJ08_3446	COG0625	glutathione transferase activity
AKJ08_3447	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
AKJ08_3459	COG0174	glutamine synthetase
AKJ08_3464	COG0411	ABC transporter
AKJ08_3466	COG0559	Belongs to the binding-protein-dependent transport system permease family
AKJ08_3469	COG1472	Belongs to the glycosyl hydrolase 3 family
AKJ08_3470	COG5002	protein histidine kinase activity
AKJ08_3473	COG0714	Associated with various cellular activities
AKJ08_3483	COG0489	protein tyrosine kinase activity
AKJ08_3483	COG3206	protein involved in exopolysaccharide biosynthesis
AKJ08_3484	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AKJ08_3487	COG0297	glycogen (starch) synthase activity
AKJ08_3489	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
AKJ08_3506	COG2814	Major facilitator Superfamily
AKJ08_3509	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AKJ08_3510	COG5002	protein histidine kinase activity
AKJ08_3510	COG2205	protein histidine kinase activity
AKJ08_3510	COG0784	Response regulator, receiver
AKJ08_3518	COG0420	3'-5' exonuclease activity
AKJ08_3520	COG0667	Aldo Keto reductase
AKJ08_3524	COG5002	protein histidine kinase activity
AKJ08_3525	COG2204	response regulator
AKJ08_3531	COG0697	spore germination
AKJ08_3537	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AKJ08_3546	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AKJ08_3559	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
AKJ08_3562	COG0662	Cupin 2, conserved barrel domain protein
AKJ08_3564	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AKJ08_3564	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AKJ08_3567	COG0006	proline dipeptidase activity
AKJ08_3571	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AKJ08_3580	COG1538	Outer membrane efflux protein
AKJ08_3581	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AKJ08_3582	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AKJ08_3588	COG1785	Belongs to the alkaline phosphatase family
AKJ08_3589	COG1785	Belongs to the alkaline phosphatase family
AKJ08_3592	COG2814	Major facilitator Superfamily
AKJ08_3606	COG1247	-acetyltransferase
AKJ08_3614	COG0318	PFAM AMP-dependent synthetase and ligase
AKJ08_3617	COG1505	serine-type exopeptidase activity
AKJ08_3618	COG1505	serine-type exopeptidase activity
AKJ08_3624	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AKJ08_3630	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AKJ08_3631	COG1301	dicarboxylic acid transport
AKJ08_3632	COG0010	Belongs to the arginase family
AKJ08_3633	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AKJ08_3636	COG0121	glutamine amidotransferase
AKJ08_3637	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AKJ08_3646	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
AKJ08_3647	COG1064	alcohol dehydrogenase
AKJ08_3649	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AKJ08_3650	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AKJ08_3650	COG0116	Belongs to the methyltransferase superfamily
AKJ08_3656	COG2826	transposase and inactivated derivatives, IS30 family
AKJ08_3660	COG2814	Major facilitator Superfamily
AKJ08_3662	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AKJ08_3665	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AKJ08_3666	COG0477	Major facilitator Superfamily
AKJ08_3667	COG0625	glutathione transferase activity
AKJ08_3668	COG0488	(ABC) transporter
AKJ08_3669	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AKJ08_3670	COG0271	Belongs to the BolA IbaG family
AKJ08_3671	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
AKJ08_3672	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
AKJ08_3673	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AKJ08_3676	COG1993	acr, cog1993
AKJ08_3678	COG0366	Alpha amylase catalytic
AKJ08_3682	COG0672	)-iron permease
AKJ08_3689	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
AKJ08_3691	COG0516	GMP reductase activity
AKJ08_3691	COG0517	IMP dehydrogenase activity
AKJ08_3692	COG2205	protein histidine kinase activity
AKJ08_3703	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AKJ08_3704	COG0154	amidase activity
AKJ08_3705	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AKJ08_3709	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AKJ08_3710	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AKJ08_3711	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AKJ08_3714	COG0483	inositol monophosphate 1-phosphatase activity
AKJ08_3715	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AKJ08_3716	COG1666	GTP binding
AKJ08_3717	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AKJ08_3723	COG2373	Large extracellular alpha-helical protein