locus-tag	class	description
wcw_0009	COG5433	transposase activity
wcw_0013	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
wcw_0015	COG2943	transferase activity, transferring hexosyl groups
wcw_0016	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
wcw_0017	COG1181	Belongs to the D-alanine--D-alanine ligase family
wcw_0020	COG0805	protein transport
wcw_0021	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
wcw_0022	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
wcw_0025	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
wcw_0031	COG2814	Major facilitator Superfamily
wcw_0032	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
wcw_0033	COG1074	ATP-dependent DNA helicase activity
wcw_0034	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
wcw_0039	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
wcw_0056	COG0560	Phosphoserine phosphatase
wcw_0057	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
wcw_0061	COG1596	polysaccharide export
wcw_0068	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
wcw_0071	COG0814	amino acid
wcw_0073	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
wcw_0074	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
wcw_0075	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
wcw_0076	COG1022	Amp-dependent synthetase and ligase
wcw_0078	COG1448	Aminotransferase
wcw_0081	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
wcw_0082	COG1747	RNA polymerase binding
wcw_0082	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
wcw_0085	COG0719	Fe-S assembly protein
wcw_0086	COG0396	ATPase activity
wcw_0087	COG0719	Fe-S assembly protein
wcw_0088	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
wcw_0089	COG0009	L-threonylcarbamoyladenylate synthase
wcw_0091	COG4791	protein targeting
wcw_0092	COG1987	bacterial-type flagellum assembly
wcw_0093	COG4790	Type iii secretion
wcw_0099	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
wcw_0100	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
wcw_0106	COG0653	protein targeting
wcw_0108	COG0688	phosphatidylethanolamine metabolic process
wcw_0109	COG0084	hydrolase, TatD family'
wcw_0112	COG1454	alcohol dehydrogenase
wcw_0117	COG0811	peptide transport
wcw_0120	COG0823	Involved in the tonB-independent uptake of proteins
wcw_0123	COG1705	Flagellar rod assembly protein muramidase FlgJ
wcw_0123	COG1388	LysM domain
wcw_0124	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
wcw_0127	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
wcw_0128	COG0745	RESPONSE REGULATOR receiver
wcw_0130	COG0697	spore germination
wcw_0133	COG0742	ribosomal rna small subunit methyltransferase
wcw_0152	COG2264	protein methyltransferase activity
wcw_0159	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
wcw_0162	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
wcw_0166	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
wcw_0171	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
wcw_0172	COG2183	response to ionizing radiation
wcw_0173	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
wcw_0183	COG2801	Transposase and inactivated derivatives
wcw_0184	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
wcw_0189	COG0814	amino acid
wcw_0190	COG0814	amino acid
wcw_0192	COG0556	nucleotide-excision repair
wcw_0194	COG0666	response to abiotic stimulus
wcw_0197	COG2050	protein possibly involved in aromatic compounds catabolism
wcw_0200	COG0848	biopolymer transport protein
wcw_0201	COG0811	peptide transport
wcw_0204	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
wcw_0205	COG0343	queuine tRNA-ribosyltransferase activity
wcw_0206	COG1862	Preprotein translocase
wcw_0207	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
wcw_0212	COG4651	solute:proton antiporter activity
wcw_0212	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
wcw_0213	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
wcw_0214	COG3202	ADP transmembrane transporter activity
wcw_0215	COG0326	Molecular chaperone. Has ATPase activity
wcw_0216	COG2871	sodium ion transport
wcw_0217	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
wcw_0217	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
wcw_0220	COG5433	transposase activity
wcw_0223	COG3335	DDE superfamily endonuclease
wcw_0227	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
wcw_0228	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
wcw_0233	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
wcw_0234	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
wcw_0237	COG2824	Alkylphosphonate utilization operon protein PhnA
wcw_0238	COG0659	secondary active sulfate transmembrane transporter activity
wcw_0239	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
wcw_0240	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
wcw_0242	COG0542	response to heat
wcw_0245	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
wcw_0246	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
wcw_0246	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
wcw_0246	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
wcw_0247	COG0756	dUTP diphosphatase activity
wcw_0248	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
wcw_0249	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
wcw_0250	COG0181	hydroxymethylbilane synthase activity
wcw_0251	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
wcw_0252	COG0571	ribonuclease III activity
wcw_0263	COG0404	The glycine cleavage system catalyzes the degradation of glycine
wcw_0264	COG0509	glycine decarboxylation via glycine cleavage system
wcw_0265	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
wcw_0266	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
wcw_0267	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
wcw_0268	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
wcw_0269	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
wcw_0270	COG1805	sodium ion transport
wcw_0275	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
wcw_0276	COG0438	transferase activity, transferring glycosyl groups
wcw_0277	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
wcw_0282	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
wcw_0285	COG0601	transmembrane transport
wcw_0286	COG3335	DDE superfamily endonuclease
wcw_0287	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
wcw_0290	COG0306	phosphate transporter
wcw_0291	COG1392	Phosphate transport regulator
wcw_0292	COG0444	Belongs to the ABC transporter superfamily
wcw_0293	COG4608	Belongs to the ABC transporter superfamily
wcw_0296	COG1187	pseudouridine synthase activity
wcw_0297	COG0588	phosphoglycerate mutase activity
wcw_0299	COG0822	iron-sulfur transferase activity
wcw_0299	COG2906	2 iron, 2 sulfur cluster binding
wcw_0299	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
wcw_0302	COG0772	Belongs to the SEDS family
wcw_0305	COG0051	transcription antitermination factor activity, RNA binding
wcw_0306	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
wcw_0307	COG0049	tRNA binding
wcw_0308	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
wcw_0312	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
wcw_0313	COG0575	Belongs to the CDS family
wcw_0314	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
wcw_0315	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
wcw_0316	COG0481	GTPase activity
wcw_0319	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
wcw_0320	COG0861	Integral membrane protein TerC family
wcw_0321	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
wcw_0322	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
wcw_0323	COG1509	lysine 2,3-aminomutase activity
wcw_0330	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
wcw_0333	COG0318	PFAM AMP-dependent synthetase and ligase
wcw_0336	COG0284	orotidine-5'-phosphate decarboxylase activity
wcw_0337	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
wcw_0339	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
wcw_0340	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
wcw_0341	COG0540	Belongs to the ATCase OTCase family
wcw_0344	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
wcw_0350	COG0275	rRNA processing
wcw_0353	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
wcw_0356	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
wcw_0357	COG0750	zinc metalloprotease
wcw_0361	COG1132	(ABC) transporter
wcw_0362	COG1132	(ABC) transporter
wcw_0365	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
wcw_0365	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
wcw_0373	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
wcw_0374	COG0101	tRNA pseudouridine synthase activity
wcw_0376	COG1408	metallophosphoesterase
wcw_0381	COG1114	Component of the transport system for branched-chain amino acids
wcw_0385	COG0217	transcriptional regulatory protein
wcw_0394	COG0442	prolyl-tRNA aminoacylation
wcw_0398	COG1025	Belongs to the peptidase M16 family
wcw_0401	COG1530	ribonuclease E activity
wcw_0404	COG0333	Belongs to the bacterial ribosomal protein bL32 family
wcw_0405	COG0416	fatty acid biosynthetic process
wcw_0410	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
wcw_0410	COG3952	Lipid A Biosynthesis
wcw_0411	COG0463	Glycosyl transferase, family 2
wcw_0415	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
wcw_0416	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
wcw_0417	COG0814	amino acid
wcw_0420	COG0420	3'-5' exonuclease activity
wcw_0421	COG0419	ATPase involved in DNA repair
wcw_0423	COG0552	protein localization to endoplasmic reticulum
wcw_0424	COG0045	succinate-CoA ligase (ADP-forming) activity
wcw_0425	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
wcw_0430	COG0446	pyridine nucleotide-disulphide oxidoreductase
wcw_0432	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
wcw_0433	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
wcw_0435	COG1301	dicarboxylic acid transport
wcw_0437	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
wcw_0439	COG0482	sulfurtransferase activity
wcw_0442	COG1028	Short-chain dehydrogenase reductase Sdr
wcw_0443	COG3387	PFAM Glycoside hydrolase 15-related
wcw_0447	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
wcw_0450	COG1024	Enoyl-CoA hydratase
wcw_0451	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
wcw_0462	COG1703	isobutyryl-CoA mutase activity
wcw_0462	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
wcw_0462	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
wcw_0464	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
wcw_0465	COG0022	dehydrogenase e1 component
wcw_0467	COG3189	MarR family transcriptional regulator
wcw_0468	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
wcw_0468	COG1017	nitric oxide dioxygenase activity
wcw_0475	COG5433	transposase activity
wcw_0478	COG1959	2 iron, 2 sulfur cluster binding
wcw_0479	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
wcw_0485	COG0109	protoheme IX farnesyltransferase activity
wcw_0488	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
wcw_0489	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
wcw_0492	COG1183	phosphatidylcholine synthase activity
wcw_0493	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
wcw_0496	COG1322	Protein conserved in bacteria
wcw_0498	COG5433	transposase activity
wcw_0500	COG3266	domain, Protein
wcw_0503	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
wcw_0504	COG0513	Belongs to the DEAD box helicase family
wcw_0507	COG2081	HI0933 family
wcw_0511	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
wcw_0511	COG3153	acetyltransferase
wcw_0513	COG1028	Short-chain dehydrogenase reductase Sdr
wcw_0514	COG1064	alcohol dehydrogenase
wcw_0515	COG3258	Cytochrome c
wcw_0517	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
wcw_0518	COG0433	COG0433 Predicted ATPase
wcw_0519	COG0667	Aldo Keto reductase
wcw_0527	COG4804	nuclease activity
wcw_0530	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
wcw_0532	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
wcw_0533	COG0681	Belongs to the peptidase S26 family
wcw_0535	COG1929	Belongs to the glycerate kinase type-1 family
wcw_0536	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
wcw_0538	COG1335	isochorismatase
wcw_0540	COG1872	DUF167
wcw_0542	COG1028	Short-chain dehydrogenase reductase Sdr
wcw_0545	COG2801	Transposase and inactivated derivatives
wcw_0547	COG5433	transposase activity
wcw_0556	COG0488	(ABC) transporter
wcw_0557	COG0583	DNA-binding transcription factor activity
wcw_0558	COG2814	Major facilitator Superfamily
wcw_0559	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
wcw_0560	COG1253	flavin adenine dinucleotide binding
wcw_0563	COG0494	nUDIX hydrolase
wcw_0564	COG0494	nUDIX hydrolase
wcw_0572	COG4286	Uncharacterised protein family (UPF0160)
wcw_0573	COG0537	adenosine 5'-monophosphoramidase activity
wcw_0576	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
wcw_0579	COG0006	proline dipeptidase activity
wcw_0580	COG0814	amino acid
wcw_0582	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
wcw_0584	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
wcw_0587	COG0250	Participates in transcription elongation, termination and antitermination
wcw_0588	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
wcw_0589	COG0081	regulation of translation
wcw_0590	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
wcw_0591	COG0222	ribosome binding
wcw_0592	COG0085	RNA polymerase activity
wcw_0593	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
wcw_0595	COG3202	ADP transmembrane transporter activity
wcw_0596	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
wcw_0603	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
wcw_0605	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
wcw_0606	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
wcw_0607	COG1394	ATPase activity, coupled to movement of substances
wcw_0608	COG1269	ATP hydrolysis coupled proton transport
wcw_0613	COG1222	aaa ATPase
wcw_0617	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
wcw_0625	COG2801	Transposase and inactivated derivatives
wcw_0626	COG2801	Transposase and inactivated derivatives
wcw_0639	COG1028	Short-chain dehydrogenase reductase Sdr
wcw_0642	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
wcw_0650	COG1830	Aldolase
wcw_0653	COG0519	Catalyzes the synthesis of GMP from XMP
wcw_0658	COG2801	Transposase and inactivated derivatives
wcw_0664	COG3335	DDE superfamily endonuclease
wcw_0669	COG0305	Participates in initiation and elongation during chromosome replication
wcw_0678	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
wcw_0679	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
wcw_0684	COG0037	tRNA processing
wcw_0685	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
wcw_0687	COG1185	polyribonucleotide nucleotidyltransferase activity
wcw_0688	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
wcw_0690	COG0590	tRNA wobble adenosine to inosine editing
wcw_0694	COG0254	rRNA binding
wcw_0695	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
wcw_0696	COG2890	protein-(glutamine-N5) methyltransferase activity
wcw_0697	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
wcw_0698	COG0228	four-way junction DNA binding
wcw_0699	COG0336	Belongs to the RNA methyltransferase TrmD family
wcw_0700	COG0335	large ribosomal subunit rRNA binding
wcw_0701	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
wcw_0705	COG1561	YicC-like family, N-terminal region
wcw_0706	COG0194	GDP metabolic process
wcw_0709	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
wcw_0709	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
wcw_0710	COG0227	Belongs to the bacterial ribosomal protein bL28 family
wcw_0715	COG0724	RNA recognition motif
wcw_0718	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
wcw_0719	COG2224	Isocitrate lyase
wcw_0721	COG0024	Methionine aminopeptidase
wcw_0722	COG0220	tRNA (guanine-N7-)-methyltransferase activity
wcw_0723	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
wcw_0725	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
wcw_0726	COG0166	Belongs to the GPI family
wcw_0728	COG4974	Belongs to the 'phage' integrase family
wcw_0731	COG0307	riboflavin synthase, alpha
wcw_0735	COG2067	long-chain fatty acid transport protein
wcw_0737	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
wcw_0738	COG0154	amidase activity
wcw_0739	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
wcw_0742	COG1090	epimerase
wcw_0744	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
wcw_0752	COG0497	DNA recombination
wcw_0754	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
wcw_0757	COG0101	tRNA pseudouridine synthase activity
wcw_0758	COG2095	MarC family integral membrane protein
wcw_0759	COG2095	MarC family integral membrane protein
wcw_0762	COG0837	glucose binding
wcw_0764	COG0436	Aminotransferase
wcw_0765	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
wcw_0766	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
wcw_0768	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
wcw_0769	COG2363	Small membrane protein
wcw_0771	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
wcw_0772	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
wcw_0774	COG0358	DNA primase activity
wcw_0781	COG1385	rRNA (uridine-N3-)-methyltransferase activity
wcw_0783	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
wcw_0784	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
wcw_0785	COG1271	oxidase subunit
wcw_0786	COG1294	oxidase, subunit
wcw_0787	COG2826	transposase and inactivated derivatives, IS30 family
wcw_0790	COG0820	rRNA (adenine-C2-)-methyltransferase activity
wcw_0792	COG0587	DNA-directed DNA polymerase activity
wcw_0793	COG0812	UDP-N-acetylmuramate dehydrogenase activity
wcw_0794	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
wcw_0797	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
wcw_0798	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
wcw_0799	COG2252	PERMEase
wcw_0803	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
wcw_0804	COG0257	Belongs to the bacterial ribosomal protein bL36 family
wcw_0805	COG0230	Belongs to the bacterial ribosomal protein bL34 family
wcw_0807	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
wcw_0809	COG1115	amino acid carrier protein
wcw_0810	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
wcw_0814	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
wcw_0815	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
wcw_0816	COG0193	aminoacyl-tRNA hydrolase activity
wcw_0817	COG0360	Binds together with S18 to 16S ribosomal RNA
wcw_0818	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
wcw_0819	COG0359	binds to the 23S rRNA
wcw_0820	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
wcw_0821	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
wcw_0821	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
wcw_0824	COG2801	Transposase and inactivated derivatives
wcw_0828	COG0277	FAD linked oxidase domain protein
wcw_0828	COG0247	lactate metabolic process
wcw_0829	COG3724	N-succinylarginine dihydrolase activity
wcw_0830	COG1012	belongs to the aldehyde dehydrogenase family
wcw_0831	COG3335	DDE superfamily endonuclease
wcw_0833	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
wcw_0840	COG0542	response to heat
wcw_0842	COG2096	Adenosyltransferase
wcw_0844	COG1640	4-alpha-glucanotransferase
wcw_0849	COG4789	Type iii secretion
wcw_0850	COG4792	protein secretion
wcw_0851	COG0012	GTP binding
wcw_0855	COG0196	riboflavin kinase activity
wcw_0856	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
wcw_0857	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
wcw_0858	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
wcw_0859	COG0195	Participates in both transcription termination and antitermination
wcw_0860	COG2183	response to ionizing radiation
wcw_0860	COG0539	negative regulation of cytoplasmic translation
wcw_0864	COG1114	Component of the transport system for branched-chain amino acids
wcw_0866	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
wcw_0867	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
wcw_0868	COG0511	ligase activity, forming carbon-carbon bonds
wcw_0869	COG0439	Biotin carboxylase
wcw_0873	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
wcw_0874	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
wcw_0878	COG0431	NADPH-dependent FMN reductase
wcw_0879	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
wcw_0881	COG0714	Associated with various cellular activities
wcw_0882	COG0037	tRNA processing
wcw_0883	COG0653	protein targeting
wcw_0888	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
wcw_0888	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
wcw_0889	COG0492	ferredoxin-NADP+ reductase activity
wcw_0892	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
wcw_0898	COG1435	thymidine kinase activity
wcw_0899	COG0488	(ABC) transporter
wcw_0901	COG0617	tRNA 3'-terminal CCA addition
wcw_0902	COG0584	glycerophosphoryl diester phosphodiesterase
wcw_0903	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
wcw_0904	COG0628	permease
wcw_0910	COG0322	excinuclease ABC activity
wcw_0913	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
wcw_0914	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
wcw_0915	COG0291	Belongs to the bacterial ribosomal protein bL35 family
wcw_0916	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
wcw_0917	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
wcw_0918	COG0564	pseudouridine synthase activity
wcw_0919	COG0859	PFAM glycosyl transferase family 9
wcw_0921	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
wcw_0922	COG1177	transmembrane transport
wcw_0923	COG1176	ABC-type spermidine putrescine transport system, permease component I
wcw_0924	COG3842	ATPase activity
wcw_0925	COG0820	rRNA (adenine-C2-)-methyltransferase activity
wcw_0926	COG0857	belongs to the CobB CobQ family
wcw_0926	COG0280	phosphate acetyltransferase
wcw_0934	COG2226	methyltransferase
wcw_0935	COG0367	asparagine synthase
wcw_0944	COG2062	phosphohistidine phosphatase, SixA
wcw_0945	COG1028	Short-chain dehydrogenase reductase Sdr
wcw_0947	COG0631	protein serine/threonine phosphatase activity
wcw_0948	COG1104	cysteine desulfurase activity
wcw_0952	COG0494	nUDIX hydrolase
wcw_0957	COG1331	Highly conserved protein containing a thioredoxin domain
wcw_0959	COG2239	Acts as a magnesium transporter
wcw_0965	COG0733	neurotransmitter:sodium symporter activity
wcw_0966	COG2255	four-way junction helicase activity
wcw_0972	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
wcw_0976	COG2089	acid synthase
wcw_0981	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
wcw_0983	COG0635	Involved in the biosynthesis of porphyrin-containing compound
wcw_0985	COG0784	Response regulator, receiver
wcw_0985	COG5002	protein histidine kinase activity
wcw_0985	COG2205	protein histidine kinase activity
wcw_0987	COG0668	transmembrane transport
wcw_0988	COG0492	ferredoxin-NADP+ reductase activity
wcw_0990	COG1333	cytochrome c biogenesis protein
wcw_0990	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
wcw_0991	COG0793	Belongs to the peptidase S41A family
wcw_0996	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
wcw_0997	COG0567	Dehydrogenase, E1 component
wcw_0998	COG0508	dehydrogenase complex catalyzes the overall conversion of
wcw_0999	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
wcw_1003	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
wcw_1006	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
wcw_1007	COG0706	membrane insertase activity
wcw_1008	COG1262	PFAM Formylglycine-generating sulfatase enzyme
wcw_1008	COG0515	serine threonine protein kinase
wcw_1009	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
wcw_1012	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
wcw_1014	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
wcw_1015	COG0470	DNA polymerase III
wcw_1017	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
wcw_1025	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
wcw_1028	COG1575	Belongs to the MenA family. Type 1 subfamily
wcw_1032	COG1216	Glycosyl transferase, family 2
wcw_1032	COG0463	Glycosyl transferase, family 2
wcw_1033	COG2226	methyltransferase
wcw_1036	COG4942	peptidase
wcw_1036	COG1418	mRNA catabolic process
wcw_1038	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
wcw_1047	COG0557	exoribonuclease II activity
wcw_1048	COG0495	leucyl-tRNA aminoacylation
wcw_1050	COG3220	belongs to the UPF0276 family
wcw_1054	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
wcw_1057	COG1228	amidohydrolase
wcw_1058	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
wcw_1059	COG2986	histidine ammonia-lyase
wcw_1062	COG1881	PFAM PEBP family protein
wcw_1063	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
wcw_1063	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
wcw_1064	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
wcw_1068	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
wcw_1073	COG1196	nuclear chromosome segregation
wcw_1073	COG3264	Mechanosensitive ion channel
wcw_1074	COG1519	Transferase
wcw_1079	COG1760	l-serine dehydratase
wcw_1081	COG0205	6-phosphofructokinase activity
wcw_1084	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
wcw_1085	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
wcw_1085	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
wcw_1087	COG1295	ribonuclease BN
wcw_1091	COG5433	transposase activity
wcw_1094	COG1598	PFAM Uncharacterised protein family UPF0150
wcw_1098	COG1125	glycine betaine transport
wcw_1098	COG0517	IMP dehydrogenase activity
wcw_1099	COG1174	glycine betaine transport
wcw_1100	COG1704	LemA family
wcw_1101	COG0501	Belongs to the peptidase M48B family
wcw_1102	COG2259	Doxx family
wcw_1106	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
wcw_1107	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
wcw_1108	COG0504	CTP synthase activity
wcw_1109	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
wcw_1112	COG0189	ligase activity
wcw_1115	COG3425	synthase
wcw_1122	COG0356	it plays a direct role in the translocation of protons across the membrane
wcw_1123	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
wcw_1124	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
wcw_1125	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
wcw_1126	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
wcw_1127	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
wcw_1128	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
wcw_1129	COG0355	proton-transporting ATP synthase activity, rotational mechanism
wcw_1132	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
wcw_1135	COG1187	pseudouridine synthase activity
wcw_1136	COG3437	response regulator, receiver
wcw_1136	COG2205	protein histidine kinase activity
wcw_1136	COG3850	Histidine kinase
wcw_1136	COG4999	Histidine kinase
wcw_1138	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
wcw_1139	COG0267	Belongs to the bacterial ribosomal protein bL33 family
wcw_1140	COG4591	ABC-type transport system involved in lipoprotein release permease component
wcw_1141	COG1136	(ABC) transporter
wcw_1145	COG0626	cystathionine gamma-synthase activity
wcw_1148	COG1063	alcohol dehydrogenase
wcw_1151	COG2217	Heavy metal translocating P-type atpase
wcw_1153	COG0242	peptide deformylase activity
wcw_1155	COG0149	triose-phosphate isomerase activity
wcw_1156	COG1570	exodeoxyribonuclease VII activity
wcw_1157	COG1722	exodeoxyribonuclease VII activity
wcw_1158	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
wcw_1163	COG2226	methyltransferase
wcw_1165	COG0424	maF-like protein
wcw_1169	COG0142	geranyltranstransferase activity
wcw_1173	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
wcw_1174	COG1477	protein flavinylation
wcw_1179	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
wcw_1180	COG0592	DNA-directed DNA polymerase activity
wcw_1181	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
wcw_1182	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
wcw_1184	COG4956	integral membrane protein (PIN domain superfamily)
wcw_1185	COG0736	holo-[acyl-carrier-protein] synthase activity
wcw_1186	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
wcw_1187	COG1028	Short-chain dehydrogenase reductase Sdr
wcw_1188	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
wcw_1189	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
wcw_1190	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
wcw_1193	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
wcw_1198	COG3335	DDE superfamily endonuclease
wcw_1201	COG0508	dehydrogenase complex catalyzes the overall conversion of
wcw_1202	COG0022	dehydrogenase e1 component
wcw_1203	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
wcw_1205	COG1301	dicarboxylic acid transport
wcw_1209	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
wcw_1211	COG4864	UPF0365 protein
wcw_1212	COG1030	water channel activity
wcw_1213	COG1030	water channel activity
wcw_1214	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
wcw_1215	COG0729	surface antigen
wcw_1218	COG0367	asparagine synthase
wcw_1220	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
wcw_1223	COG1678	Uncharacterized ACR, COG1678
wcw_1224	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
wcw_1226	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
wcw_1228	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
wcw_1230	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
wcw_1231	COG1231	oxidoreductase activity
wcw_1233	COG2003	Belongs to the UPF0758 family
wcw_1234	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
wcw_1235	COG0321	lipoyl(octanoyl) transferase activity
wcw_1235	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
wcw_1237	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
wcw_1237	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
wcw_1241	COG0039	L-malate dehydrogenase activity
wcw_1242	COG0602	queuosine metabolic process
wcw_1250	COG0563	adenylate kinase activity
wcw_1260	COG0123	including yeast histone deacetylase and acetoin utilization protein
wcw_1261	COG0471	metal ion transport
wcw_1262	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
wcw_1263	COG0531	amino acid
wcw_1265	COG0431	NADPH-dependent FMN reductase
wcw_1274	COG1024	Enoyl-CoA hydratase
wcw_1274	COG1250	3-hydroxyacyl-CoA dehydrogenase
wcw_1275	COG0183	Belongs to the thiolase family
wcw_1276	COG1022	Amp-dependent synthetase and ligase
wcw_1278	COG3335	DDE superfamily endonuclease
wcw_1279	COG2270	Major facilitator Superfamily
wcw_1282	COG0752	glycyl-tRNA synthetase alpha subunit
wcw_1282	COG0751	glycine-tRNA ligase activity
wcw_1298	COG0596	Alpha beta hydrolase
wcw_1300	COG1181	Belongs to the D-alanine--D-alanine ligase family
wcw_1302	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
wcw_1303	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
wcw_1304	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
wcw_1309	COG0457	Tetratricopeptide repeat
wcw_1309	COG0515	serine threonine protein kinase
wcw_1314	COG0525	valine-tRNA ligase activity
wcw_1316	COG1115	amino acid carrier protein
wcw_1317	COG1115	amino acid carrier protein
wcw_1318	COG1320	monovalent cation:proton antiporter activity
wcw_1319	COG2212	antiporter activity
wcw_1323	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
wcw_1323	COG2111	Na H antiporter
wcw_1325	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
wcw_1329	COG1132	(ABC) transporter
wcw_1331	COG0825	malonyl-CoA metabolic process
wcw_1333	COG0776	regulation of translation
wcw_1334	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
wcw_1336	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
wcw_1337	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
wcw_1339	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
wcw_1341	COG1164	Oligoendopeptidase f
wcw_1342	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
wcw_1343	COG0459	protein refolding
wcw_1348	COG3657	addiction module killer protein
wcw_1352	COG0537	adenosine 5'-monophosphoramidase activity
wcw_1353	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
wcw_1358	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
wcw_1360	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
wcw_1369	COG0215	cysteine-tRNA ligase activity
wcw_1370	COG0318	PFAM AMP-dependent synthetase and ligase
wcw_1370	COG0204	Acyl-transferase
wcw_1373	COG0494	nUDIX hydrolase
wcw_1374	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
wcw_1375	COG0799	negative regulation of ribosome biogenesis
wcw_1380	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
wcw_1381	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
wcw_1382	COG0629	single-stranded DNA binding
wcw_1385	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
wcw_1386	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
wcw_1387	COG0772	Belongs to the SEDS family
wcw_1388	COG3584	3D domain protein
wcw_1388	COG1388	LysM domain
wcw_1389	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
wcw_1390	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
wcw_1393	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
wcw_1395	COG0157	Belongs to the NadC ModD family
wcw_1396	COG0459	protein refolding
wcw_1398	COG4139	cobalamin transport
wcw_1405	COG0733	neurotransmitter:sodium symporter activity
wcw_1407	COG0489	protein tyrosine kinase activity
wcw_1408	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
wcw_1412	COG4221	oxidoreductase activity
wcw_1415	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
wcw_1419	COG2801	Transposase and inactivated derivatives
wcw_1423	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
wcw_1424	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
wcw_1425	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
wcw_1426	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
wcw_1427	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
wcw_1432	COG1968	undecaprenyl-diphosphatase activity
wcw_1433	COG1674	ftsk spoiiie
wcw_1434	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
wcw_1435	COG0484	heat shock protein binding
wcw_1437	COG0828	Belongs to the bacterial ribosomal protein bS21 family
wcw_1438	COG1214	PFAM Peptidase M22, glycoprotease
wcw_1439	COG0232	Belongs to the dGTPase family. Type 2 subfamily
wcw_1442	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
wcw_1443	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
wcw_1443	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
wcw_1445	COG1234	tRNA 3'-trailer cleavage
wcw_1446	COG4974	Belongs to the 'phage' integrase family
wcw_1449	COG0488	(ABC) transporter
wcw_1451	COG0302	gtp cyclohydrolase
wcw_1453	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
wcw_1454	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
wcw_1455	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
wcw_1457	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
wcw_1458	COG0740	serine-type endopeptidase activity
wcw_1459	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
wcw_1466	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
wcw_1469	COG0534	Mate efflux family protein
wcw_1472	COG1250	3-hydroxyacyl-CoA dehydrogenase
wcw_1472	COG1024	Enoyl-CoA hydratase
wcw_1473	COG1024	Enoyl-CoA hydratase
wcw_1474	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
wcw_1475	COG0372	Belongs to the citrate synthase family
wcw_1476	COG2079	MmgE PrpD family protein
wcw_1477	COG2814	Major facilitator Superfamily
wcw_1479	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
wcw_1480	COG0203	ribosomal protein L17
wcw_1481	COG0202	RNA polymerase activity
wcw_1482	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
wcw_1483	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
wcw_1485	COG0200	Binds to the 23S rRNA
wcw_1486	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
wcw_1487	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
wcw_1488	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
wcw_1489	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
wcw_1490	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
wcw_1491	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
wcw_1492	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
wcw_1493	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
wcw_1494	COG0255	Belongs to the universal ribosomal protein uL29 family
wcw_1495	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
wcw_1496	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
wcw_1497	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
wcw_1498	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
wcw_1499	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
wcw_1500	COG0089	rRNA binding
wcw_1501	COG0088	Forms part of the polypeptide exit tunnel
wcw_1502	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
wcw_1507	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
wcw_1508	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
wcw_1509	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
wcw_1510	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
wcw_1511	COG0815	Transfers the fatty acyl group on membrane lipoproteins
wcw_1515	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
wcw_1515	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
wcw_1517	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
wcw_1519	COG1686	Belongs to the peptidase S11 family
wcw_1523	COG0587	DNA-directed DNA polymerase activity
wcw_1526	COG0124	histidyl-tRNA synthetase
wcw_1527	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
wcw_1530	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
wcw_1531	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
wcw_1542	COG0072	phenylalanine-tRNA ligase activity
wcw_1542	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
wcw_1543	COG0105	UTP biosynthetic process
wcw_1545	COG0105	UTP biosynthetic process
wcw_1548	COG1137	ATPase activity
wcw_1550	COG2877	3-deoxy-8-phosphooctulonate synthase activity
wcw_1554	COG1837	Belongs to the UPF0109 family
wcw_1555	COG1490	D-aminoacyl-tRNA deacylase activity
wcw_1563	COG1086	Polysaccharide biosynthesis protein
wcw_1564	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
wcw_1566	COG0017	Asparaginyl-tRNA synthetase
wcw_1567	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
wcw_1568	COG0728	peptidoglycan biosynthetic process
wcw_1570	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
wcw_1572	COG2204	response regulator
wcw_1574	COG3335	DDE superfamily endonuclease
wcw_1579	COG3335	DDE superfamily endonuclease
wcw_1585	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
wcw_1590	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
wcw_1591	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
wcw_1591	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
wcw_1592	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
wcw_1594	COG1077	Cell shape determining protein MreB Mrl
wcw_1595	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
wcw_1597	COG0544	peptidyl-prolyl cis-trans isomerase activity
wcw_1598	COG0740	serine-type endopeptidase activity
wcw_1599	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
wcw_1620	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
wcw_1620	COG1776	CheC inhibitor of MCP methylation
wcw_1621	COG2815	serine threonine protein kinase
wcw_1621	COG0515	serine threonine protein kinase
wcw_1622	COG1450	Type ii and iii secretion system protein
wcw_1624	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
wcw_1626	COG1160	GTP binding
wcw_1627	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
wcw_1628	COG0686	Belongs to the AlaDH PNT family
wcw_1629	COG1196	nuclear chromosome segregation
wcw_1630	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
wcw_1636	COG1420	regulation of RNA biosynthetic process
wcw_1637	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
wcw_1638	COG0443	Heat shock 70 kDa protein
wcw_1641	COG1619	proteins homologs of microcin C7 resistance protein MccF
wcw_1644	COG0616	signal peptide processing
wcw_1646	COG0237	dephospho-CoA kinase activity
wcw_1647	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
wcw_1649	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
wcw_1650	COG0211	Belongs to the bacterial ribosomal protein bL27 family
wcw_1651	COG0261	This protein binds to 23S rRNA in the presence of protein L20
wcw_1652	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
wcw_1657	COG0149	triose-phosphate isomerase activity
wcw_1658	COG0518	GMP synthase (glutamine-hydrolyzing) activity
wcw_1658	COG0519	Catalyzes the synthesis of GMP from XMP
wcw_1665	COG0793	Belongs to the peptidase S41A family
wcw_1666	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
wcw_1669	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
wcw_1672	COG1121	(ABC) transporter
wcw_1673	COG0803	Belongs to the bacterial solute-binding protein 9 family
wcw_1675	COG0489	protein tyrosine kinase activity
wcw_1678	COG3202	ADP transmembrane transporter activity
wcw_1680	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
wcw_1680	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
wcw_1681	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
wcw_1681	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
wcw_1684	COG0793	Belongs to the peptidase S41A family
wcw_1685	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
wcw_1688	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
wcw_1694	COG2801	Transposase and inactivated derivatives
wcw_1697	COG0735	belongs to the Fur family
wcw_1698	COG3202	ADP transmembrane transporter activity
wcw_1699	COG3202	ADP transmembrane transporter activity
wcw_1700	COG0126	phosphoglycerate kinase activity
wcw_1701	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
wcw_1702	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
wcw_1703	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
wcw_1704	COG0218	Necessary for normal cell division and for the maintenance of normal septation
wcw_1705	COG0802	atpase or kinase
wcw_1708	COG0018	arginyl-trna synthetase
wcw_1709	COG2217	Heavy metal translocating P-type atpase
wcw_1713	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
wcw_1716	COG0842	Transport permease protein
wcw_1717	COG0842	Transport permease protein
wcw_1718	COG1131	(ABC) transporter
wcw_1719	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
wcw_1726	COG3273	potassium ion transport
wcw_1726	COG0471	metal ion transport
wcw_1729	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
wcw_1729	COG0517	IMP dehydrogenase activity
wcw_1730	COG0473	3-isopropylmalate dehydrogenase activity
wcw_1731	COG1301	dicarboxylic acid transport
wcw_1732	COG1663	tetraacyldisaccharide 4'-kinase activity
wcw_1733	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
wcw_1744	COG0564	pseudouridine synthase activity
wcw_1745	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
wcw_1747	COG1058	Belongs to the CinA family
wcw_1747	COG1546	Belongs to the CinA family
wcw_1750	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
wcw_1751	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
wcw_1754	COG1611	Belongs to the LOG family
wcw_1758	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
wcw_1759	COG0483	inositol monophosphate 1-phosphatase activity
wcw_1760	COG4285	Biotin-protein ligase, N terminal
wcw_1761	COG1268	BioY protein
wcw_1767	COG0408	coproporphyrinogen oxidase activity
wcw_1768	COG0442	prolyl-tRNA aminoacylation
wcw_1772	COG1108	ABC-type Mn2 Zn2 transport systems permease components
wcw_1775	COG0305	Participates in initiation and elongation during chromosome replication
wcw_1776	COG0445	tRNA wobble uridine modification
wcw_1778	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
wcw_1782	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
wcw_1783	COG1053	succinate dehydrogenase
wcw_1784	COG2009	succinate dehydrogenase
wcw_1785	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
wcw_1786	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
wcw_1787	COG0632	four-way junction helicase activity
wcw_1788	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
wcw_1793	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
wcw_1797	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
wcw_1797	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
wcw_1799	COG0463	Glycosyl transferase, family 2
wcw_1799	COG0457	Tetratricopeptide repeat
wcw_1808	COG2801	Transposase and inactivated derivatives
wcw_1815	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
wcw_1816	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
wcw_1821	COG0438	transferase activity, transferring glycosyl groups
wcw_1825	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
wcw_1826	COG1538	Outer membrane efflux protein
wcw_1835	COG0560	Phosphoserine phosphatase
wcw_1838	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
wcw_1841	COG1012	belongs to the aldehyde dehydrogenase family
wcw_1846	COG1012	belongs to the aldehyde dehydrogenase family
wcw_1847	COG3876	Protein conserved in bacteria
wcw_1848	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
wcw_1849	COG0459	protein refolding
wcw_1854	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
wcw_1859	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
wcw_1860	COG0450	alkyl hydroperoxide reductase
wcw_1862	COG0148	phosphopyruvate hydratase activity
wcw_1863	COG1162	GTPase activity
wcw_1866	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
wcw_1867	COG0617	tRNA 3'-terminal CCA addition
wcw_1868	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
wcw_1871	COG0714	Associated with various cellular activities
wcw_1878	COG0058	SHG alpha-glucan phosphorylase activity
wcw_1879	COG0366	Alpha amylase catalytic
wcw_1880	COG0366	Alpha amylase catalytic
wcw_1881	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
wcw_1885	COG2801	Transposase and inactivated derivatives
wcw_1890	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
wcw_1896	COG5433	transposase activity
wcw_1897	COG2801	Transposase and inactivated derivatives
wcw_1909	COG2165	general secretion pathway protein
wcw_1912	COG1459	type II secretion system
wcw_1913	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
wcw_1918	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
wcw_1919	COG0668	transmembrane transport
wcw_1921	COG0584	glycerophosphoryl diester phosphodiesterase
wcw_1925	COG0384	phenazine biosynthesis protein PhzF
wcw_1931	COG0768	penicillin binding
wcw_1933	COG0052	Belongs to the universal ribosomal protein uS2 family
wcw_1934	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
wcw_1935	COG0528	UMP kinase activity
wcw_1936	COG0233	cytoplasmic translational termination
wcw_1939	COG3880	PFAM UvrB UvrC protein
wcw_1940	COG3869	Catalyzes the specific phosphorylation of arginine residues in
wcw_1943	COG0268	Binds directly to 16S ribosomal RNA
wcw_1944	COG0564	pseudouridine synthase activity
wcw_1949	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
wcw_1950	COG1199	ATP-dependent helicase activity
wcw_1954	COG1640	4-alpha-glucanotransferase
wcw_1971	COG1254	Belongs to the acylphosphatase family
wcw_1973	COG0762	integral membrane protein
wcw_1977	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
wcw_1978	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
wcw_p0001	COG0582	viral genome integration into host DNA
wcw_p0002	COG3657	addiction module killer protein