locus-tag	class	description
Weevi_0001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
Weevi_0002	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
Weevi_0003	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
Weevi_0007	COG0629	single-stranded DNA binding
Weevi_0009	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
Weevi_0010	COG0569	domain protein
Weevi_0012	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Weevi_0014	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
Weevi_0015	COG1028	Short-chain dehydrogenase reductase Sdr
Weevi_0016	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
Weevi_0019	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Weevi_0020	COG1216	Glycosyl transferase, family 2
Weevi_0020	COG0463	Glycosyl transferase, family 2
Weevi_0025	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
Weevi_0032	COG0431	NADPH-dependent FMN reductase
Weevi_0033	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
Weevi_0034	COG1918	ferrous iron import across plasma membrane
Weevi_0034	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
Weevi_0036	COG1301	dicarboxylic acid transport
Weevi_0055	COG2217	Heavy metal translocating P-type atpase
Weevi_0071	COG0129	dihydroxy-acid dehydratase activity
Weevi_0072	COG0028	Belongs to the TPP enzyme family
Weevi_0073	COG0440	acetolactate synthase activity
Weevi_0074	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
Weevi_0075	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
Weevi_0081	COG3059	membrane
Weevi_0085	COG4413	Urea transporter
Weevi_0086	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
Weevi_0088	COG1401	restriction endodeoxyribonuclease activity
Weevi_0089	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
Weevi_0091	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
Weevi_0094	COG3392	D12 class N6 adenine-specific DNA methyltransferase
Weevi_0125	COG2003	Belongs to the UPF0758 family
Weevi_0149	COG1230	cation diffusion facilitator family transporter
Weevi_0153	COG1002	Type II restriction enzyme, methylase subunits
Weevi_0160	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
Weevi_0161	COG4974	Belongs to the 'phage' integrase family
Weevi_0162	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
Weevi_0163	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
Weevi_0164	COG0569	domain protein
Weevi_0171	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
Weevi_0176	COG2890	protein-(glutamine-N5) methyltransferase activity
Weevi_0177	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
Weevi_0179	COG1183	phosphatidylcholine synthase activity
Weevi_0180	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
Weevi_0181	COG0179	Fumarylacetoacetate (FAA) hydrolase
Weevi_0183	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
Weevi_0185	COG0450	alkyl hydroperoxide reductase
Weevi_0186	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
Weevi_0188	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
Weevi_0189	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
Weevi_0189	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
Weevi_0194	COG3591	Belongs to the peptidase S1B family
Weevi_0196	COG1012	belongs to the aldehyde dehydrogenase family
Weevi_0197	COG1960	acyl-CoA dehydrogenase activity
Weevi_0200	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
Weevi_0201	COG0586	Pfam SNARE associated Golgi protein
Weevi_0202	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
Weevi_0204	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Weevi_0204	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Weevi_0205	COG1739	Uncharacterized protein family UPF0029
Weevi_0207	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
Weevi_0209	COG3185	4-Hydroxyphenylpyruvate dioxygenase
Weevi_0212	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
Weevi_0217	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Weevi_0227	COG1538	Outer membrane efflux protein
Weevi_0288	COG0423	glycine-tRNA ligase activity
Weevi_0289	COG1950	PFAM Membrane protein of
Weevi_0290	COG1360	Flagellar Motor Protein
Weevi_0291	COG1652	LysM domain
Weevi_0293	COG0252	asparaginase activity
Weevi_0295	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
Weevi_0298	COG0666	response to abiotic stimulus
Weevi_0299	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
Weevi_0300	COG0505	Belongs to the CarA family
Weevi_0301	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Weevi_0302	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
Weevi_0303	COG0137	argininosuccinate synthase activity
Weevi_0304	COG1438	arginine binding
Weevi_0306	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
Weevi_0333	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
Weevi_0341	COG0420	3'-5' exonuclease activity
Weevi_0342	COG0419	ATPase involved in DNA repair
Weevi_0343	COG0326	Molecular chaperone. Has ATPase activity
Weevi_0345	COG1428	Deoxynucleoside kinase
Weevi_0347	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Weevi_0348	COG0719	Fe-S assembly protein
Weevi_0349	COG0396	ATPase activity
Weevi_0350	COG0719	Fe-S assembly protein
Weevi_0351	COG0316	Belongs to the HesB IscA family
Weevi_0352	COG0180	Tryptophanyl-tRNA synthetase
Weevi_0354	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
Weevi_0359	COG0656	L-ascorbic acid biosynthetic process
Weevi_0363	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
Weevi_0365	COG1858	cytochrome C peroxidase
Weevi_0367	COG1999	signal sequence binding
Weevi_0370	COG2326	polyphosphate kinase activity
Weevi_0376	COG0335	large ribosomal subunit rRNA binding
Weevi_0377	COG0194	GDP metabolic process
Weevi_0378	COG1561	YicC-like family, N-terminal region
Weevi_0379	COG1228	amidohydrolase
Weevi_0380	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
Weevi_0383	COG2195	Cleaves the N-terminal amino acid of tripeptides
Weevi_0385	COG1169	isochorismate synthase
Weevi_0386	COG2050	protein possibly involved in aromatic compounds catabolism
Weevi_0391	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
Weevi_0394	COG0254	rRNA binding
Weevi_0396	COG2234	aminopeptidase activity
Weevi_0397	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
Weevi_0398	COG1960	acyl-CoA dehydrogenase activity
Weevi_0399	COG0183	Belongs to the thiolase family
Weevi_0400	COG1024	Enoyl-CoA hydratase
Weevi_0400	COG1250	3-hydroxyacyl-CoA dehydrogenase
Weevi_0401	COG1846	Transcriptional regulator
Weevi_0404	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
Weevi_0407	COG4221	oxidoreductase activity
Weevi_0409	COG0288	reversible hydration of carbon dioxide
Weevi_0411	COG0592	DNA-directed DNA polymerase activity
Weevi_0414	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
Weevi_0416	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Weevi_0417	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
Weevi_0418	COG0156	8-amino-7-oxononanoate synthase activity
Weevi_0421	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
Weevi_0422	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Weevi_0425	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
Weevi_0426	COG2255	four-way junction helicase activity
Weevi_0427	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
Weevi_0429	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
Weevi_0430	COG0181	hydroxymethylbilane synthase activity
Weevi_0432	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
Weevi_0436	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
Weevi_0438	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
Weevi_0439	COG0386	Belongs to the glutathione peroxidase family
Weevi_0440	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
Weevi_0440	COG1333	cytochrome c biogenesis protein
Weevi_0441	COG0693	protein deglycase activity
Weevi_0442	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
Weevi_0445	COG0463	Glycosyl transferase, family 2
Weevi_0450	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
Weevi_0451	COG1012	belongs to the aldehyde dehydrogenase family
Weevi_0460	COG0823	Involved in the tonB-independent uptake of proteins
Weevi_0460	COG1506	peptidase
Weevi_0464	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
Weevi_0465	COG0730	response to heat
Weevi_0467	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Weevi_0468	COG0288	reversible hydration of carbon dioxide
Weevi_0469	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
Weevi_0470	COG1053	succinate dehydrogenase
Weevi_0480	COG0508	dehydrogenase complex catalyzes the overall conversion of
Weevi_0482	COG3852	Histidine kinase
Weevi_0483	COG2239	Acts as a magnesium transporter
Weevi_0484	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
Weevi_0485	COG2177	Part of the ABC transporter FtsEX involved in
Weevi_0487	COG1968	undecaprenyl-diphosphatase activity
Weevi_0488	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
Weevi_0491	COG0427	acetyl-CoA hydrolase
Weevi_0494	COG0754	glutathionylspermidine amidase activity
Weevi_0496	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
Weevi_0497	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Weevi_0498	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
Weevi_0499	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Weevi_0500	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Weevi_0500	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
Weevi_0501	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Weevi_0502	COG1078	dGTPase activity
Weevi_0503	COG2204	response regulator
Weevi_0504	COG0802	atpase or kinase
Weevi_0505	COG0686	Belongs to the AlaDH PNT family
Weevi_0507	COG3040	lipid binding
Weevi_0508	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
Weevi_0509	COG1181	Belongs to the D-alanine--D-alanine ligase family
Weevi_0511	COG0564	pseudouridine synthase activity
Weevi_0512	COG1058	Belongs to the CinA family
Weevi_0512	COG1546	Belongs to the CinA family
Weevi_0513	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
Weevi_0515	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
Weevi_0519	COG1074	ATP-dependent DNA helicase activity
Weevi_0520	COG0322	excinuclease ABC activity
Weevi_0523	COG1629	transport
Weevi_0523	COG4206	TonB-dependent receptor
Weevi_0526	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
Weevi_0527	COG0404	The glycine cleavage system catalyzes the degradation of glycine
Weevi_0530	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
Weevi_0532	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
Weevi_0533	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
Weevi_0533	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
Weevi_0534	COG0799	negative regulation of ribosome biogenesis
Weevi_0535	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Weevi_0537	COG4589	Belongs to the CDS family
Weevi_0538	COG0688	phosphatidylethanolamine metabolic process
Weevi_0541	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
Weevi_0542	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Weevi_0546	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
Weevi_0551	COG1262	PFAM Formylglycine-generating sulfatase enzyme
Weevi_0555	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Weevi_0556	COG3829	transcription factor binding
Weevi_0561	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
Weevi_0562	COG0459	protein refolding
Weevi_0563	COG0579	oxidoreductase
Weevi_0564	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
Weevi_0567	COG0438	transferase activity, transferring glycosyl groups
Weevi_0568	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
Weevi_0568	COG0463	Glycosyl transferase, family 2
Weevi_0569	COG0438	transferase activity, transferring glycosyl groups
Weevi_0573	COG1136	(ABC) transporter
Weevi_0574	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
Weevi_0575	COG0612	Peptidase, M16
Weevi_0576	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Weevi_0578	COG0463	Glycosyl transferase, family 2
Weevi_0580	COG0504	CTP synthase activity
Weevi_0581	COG0706	membrane insertase activity
Weevi_0583	COG1862	Preprotein translocase
Weevi_0585	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Weevi_0586	COG1132	(ABC) transporter
Weevi_0588	COG2261	transglycosylase associated protein
Weevi_0589	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Weevi_0592	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
Weevi_0593	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
Weevi_0594	COG0489	protein tyrosine kinase activity
Weevi_0597	COG1215	transferase activity, transferring glycosyl groups
Weevi_0599	COG1442	glycosyl transferase family 8
Weevi_0599	COG1216	Glycosyl transferase, family 2
Weevi_0600	COG0438	transferase activity, transferring glycosyl groups
Weevi_0605	COG1028	Short-chain dehydrogenase reductase Sdr
Weevi_0607	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
Weevi_0609	COG1216	Glycosyl transferase, family 2
Weevi_0611	COG1216	Glycosyl transferase, family 2
Weevi_0613	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
Weevi_0622	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
Weevi_0623	COG0564	pseudouridine synthase activity
Weevi_0626	COG1335	isochorismatase
Weevi_0629	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
Weevi_0630	COG2226	methyltransferase
Weevi_0633	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
Weevi_0636	COG0805	protein transport
Weevi_0638	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
Weevi_0640	COG2211	Major facilitator Superfamily
Weevi_0641	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
Weevi_0643	COG0105	UTP biosynthetic process
Weevi_0644	COG4771	TonB-dependent receptor
Weevi_0646	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
Weevi_0647	COG0424	maF-like protein
Weevi_0648	COG0428	transporter
Weevi_0649	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Weevi_0650	COG0167	dihydroorotate dehydrogenase activity
Weevi_0654	COG0542	response to heat
Weevi_0655	COG1388	LysM domain
Weevi_0655	COG3942	CHAP domain
Weevi_0656	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
Weevi_0657	COG0584	glycerophosphoryl diester phosphodiesterase
Weevi_0660	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
Weevi_0666	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Weevi_0669	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
Weevi_0673	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
Weevi_0675	COG0045	succinate-CoA ligase (ADP-forming) activity
Weevi_0679	COG1610	YqeY-like protein
Weevi_0680	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
Weevi_0683	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
Weevi_0684	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
Weevi_0686	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
Weevi_0687	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Weevi_0688	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
Weevi_0689	COG0768	penicillin binding
Weevi_0691	COG0275	rRNA processing
Weevi_0692	COG2001	Belongs to the MraZ family
Weevi_0694	COG0218	Necessary for normal cell division and for the maintenance of normal septation
Weevi_0695	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
Weevi_0697	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Weevi_0698	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
Weevi_0699	COG3720	iron ion transport
Weevi_0703	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
Weevi_0707	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
Weevi_0708	COG1970	mechanosensitive ion channel activity
Weevi_0711	COG0442	prolyl-tRNA aminoacylation
Weevi_0713	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
Weevi_0717	COG0508	dehydrogenase complex catalyzes the overall conversion of
Weevi_0719	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
Weevi_0720	COG0085	RNA polymerase activity
Weevi_0721	COG0222	ribosome binding
Weevi_0722	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
Weevi_0723	COG0081	regulation of translation
Weevi_0724	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
Weevi_0727	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Weevi_0729	COG4974	Belongs to the 'phage' integrase family
Weevi_0730	COG0828	Belongs to the bacterial ribosomal protein bS21 family
Weevi_0731	COG1960	acyl-CoA dehydrogenase activity
Weevi_0732	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
Weevi_0733	COG1012	belongs to the aldehyde dehydrogenase family
Weevi_0736	COG0022	dehydrogenase e1 component
Weevi_0742	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
Weevi_0743	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
Weevi_0744	COG0268	Binds directly to 16S ribosomal RNA
Weevi_0745	COG0791	NLP P60 protein
Weevi_0750	COG1611	Belongs to the LOG family
Weevi_0754	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
Weevi_0755	COG0545	Peptidyl-prolyl cis-trans isomerase
Weevi_0757	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
Weevi_0758	COG1674	ftsk spoiiie
Weevi_0760	COG0795	lipopolysaccharide-transporting ATPase activity
Weevi_0761	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Weevi_0761	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Weevi_0763	COG0708	Exodeoxyribonuclease III
Weevi_0764	COG3047	cAMP biosynthetic process
Weevi_0764	COG2885	chlorophyll binding
Weevi_0767	COG0494	nUDIX hydrolase
Weevi_0768	COG4974	Belongs to the 'phage' integrase family
Weevi_0769	COG0793	Belongs to the peptidase S41A family
Weevi_0774	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
Weevi_0776	COG0742	ribosomal rna small subunit methyltransferase
Weevi_0779	COG0539	negative regulation of cytoplasmic translation
Weevi_0780	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
Weevi_0787	COG1506	peptidase
Weevi_0787	COG0823	Involved in the tonB-independent uptake of proteins
Weevi_0788	COG3104	oligopeptide transport
Weevi_0789	COG3104	oligopeptide transport
Weevi_0790	COG3104	oligopeptide transport
Weevi_0792	COG2333	competence protein COMEC
Weevi_0792	COG0658	competence protein
Weevi_0797	COG4464	protein tyrosine phosphatase activity
Weevi_0798	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
Weevi_0802	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
Weevi_0803	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Weevi_0804	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Weevi_0805	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Weevi_0806	COG0649	NAD binding
Weevi_0807	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
Weevi_0808	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
Weevi_0809	COG1034	ATP synthesis coupled electron transport
Weevi_0810	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
Weevi_0811	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Weevi_0813	COG0713	ATP synthesis coupled electron transport
Weevi_0814	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
Weevi_0815	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Weevi_0816	COG1007	ATP synthesis coupled electron transport
Weevi_0818	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
Weevi_0820	COG3384	dioxygenase
Weevi_0822	COG0509	glycine decarboxylation via glycine cleavage system
Weevi_0824	COG0632	four-way junction helicase activity
Weevi_0827	COG0348	domain, Protein
Weevi_0832	COG2217	Heavy metal translocating P-type atpase
Weevi_0836	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
Weevi_0838	COG1418	mRNA catabolic process
Weevi_0840	COG0228	four-way junction DNA binding
Weevi_0841	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
Weevi_0843	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Weevi_0845	COG2003	Belongs to the UPF0758 family
Weevi_0848	COG0546	phosphoglycolate phosphatase activity
Weevi_0851	COG0328	RNA-DNA hybrid ribonuclease activity
Weevi_0855	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
Weevi_0856	COG1703	isobutyryl-CoA mutase activity
Weevi_0872	COG3263	regulation of cellular component size
Weevi_0877	COG0196	riboflavin kinase activity
Weevi_0878	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
Weevi_0879	COG0355	proton-transporting ATP synthase activity, rotational mechanism
Weevi_0880	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
Weevi_0881	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
Weevi_0883	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Weevi_0884	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Weevi_0885	COG1774	PSP1 C-terminal conserved region
Weevi_0888	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
Weevi_0889	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
Weevi_0891	COG0157	Belongs to the NadC ModD family
Weevi_0893	COG1619	proteins homologs of microcin C7 resistance protein MccF
Weevi_0895	COG0792	nuclease activity
Weevi_0896	COG0586	Pfam SNARE associated Golgi protein
Weevi_0897	COG0586	Pfam SNARE associated Golgi protein
Weevi_0902	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
Weevi_0904	COG0826	peptidase U32
Weevi_0905	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Weevi_0910	COG1381	Involved in DNA repair and RecF pathway recombination
Weevi_0912	COG0758	DNA mediated transformation
Weevi_0914	COG1607	acyl-coa hydrolase
Weevi_0917	COG0189	ligase activity
Weevi_0919	COG0193	aminoacyl-tRNA hydrolase activity
Weevi_0920	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Weevi_0921	COG3530	Putative quorum-sensing-regulated virulence factor
Weevi_0922	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
Weevi_0923	COG1160	GTP binding
Weevi_0925	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Weevi_0925	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Weevi_0926	COG1024	Enoyl-CoA hydratase
Weevi_0928	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
Weevi_0929	COG0512	Glutamine amidotransferase of anthranilate synthase
Weevi_0930	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Weevi_0931	COG0134	indole-3-glycerol-phosphate synthase activity
Weevi_0932	COG0135	phosphoribosylanthranilate isomerase activity
Weevi_0933	COG0133	tryptophan synthase activity
Weevi_0951	COG1045	serine acetyltransferase
Weevi_0952	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
Weevi_0962	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
Weevi_0963	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Weevi_0964	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
Weevi_0964	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
Weevi_0966	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
Weevi_0968	COG0508	dehydrogenase complex catalyzes the overall conversion of
Weevi_0968	COG0022	dehydrogenase e1 component
Weevi_0971	COG1253	flavin adenine dinucleotide binding
Weevi_0975	COG0463	Glycosyl transferase, family 2
Weevi_0978	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
Weevi_0979	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
Weevi_0981	COG0297	glycogen (starch) synthase activity
Weevi_0982	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
Weevi_0983	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
Weevi_0985	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
Weevi_0988	COG1040	competence protein
Weevi_0989	COG0720	synthase
Weevi_1000	COG1435	thymidine kinase activity
Weevi_1001	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
Weevi_1002	COG1752	Esterase of the alpha-beta hydrolase superfamily
Weevi_1003	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
Weevi_1004	COG0445	tRNA wobble uridine modification
Weevi_1007	COG2885	chlorophyll binding
Weevi_1010	COG1741	Belongs to the pirin family
Weevi_1011	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Weevi_1012	COG2166	iron-sulfur cluster assembly
Weevi_1015	COG0557	exoribonuclease II activity
Weevi_1017	COG0698	ribose 5-phosphate isomerase
Weevi_1018	COG0126	phosphoglycerate kinase activity
Weevi_1020	COG0714	Associated with various cellular activities
Weevi_1024	COG2304	oxidoreductase activity
Weevi_1027	COG2095	MarC family integral membrane protein
Weevi_1029	COG0594	ribonuclease P activity
Weevi_1032	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
Weevi_1036	COG1113	amino acid transport
Weevi_1037	COG3118	belongs to the thioredoxin family
Weevi_1038	COG0481	GTPase activity
Weevi_1041	COG2375	cellular response to nickel ion
Weevi_1042	COG4607	ABC-type enterochelin transport system periplasmic component
Weevi_1043	COG4604	ABC transporter, ATP-binding protein
Weevi_1044	COG4605	iron ion homeostasis
Weevi_1045	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Weevi_1046	COG0470	DNA polymerase III
Weevi_1053	COG0429	hydrolase of the alpha beta-hydrolase fold
Weevi_1055	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
Weevi_1056	COG0124	histidyl-tRNA synthetase
Weevi_1059	COG0602	queuosine metabolic process
Weevi_1060	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
Weevi_1061	COG2081	HI0933 family
Weevi_1067	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
Weevi_1070	COG0571	ribonuclease III activity
Weevi_1071	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Weevi_1072	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Weevi_1073	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
Weevi_1074	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
Weevi_1075	COG5000	phosphorelay sensor kinase activity
Weevi_1079	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Weevi_1084	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
Weevi_1088	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
Weevi_1093	COG0159	tryptophan synthase activity
Weevi_1094	COG3033	Beta-eliminating lyase
Weevi_1096	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
Weevi_1097	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
Weevi_1098	COG0598	Magnesium transport protein CorA
Weevi_1100	COG4206	TonB-dependent receptor
Weevi_1100	COG1629	transport
Weevi_1104	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
Weevi_1110	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
Weevi_1115	COG1187	pseudouridine synthase activity
Weevi_1116	COG0211	Belongs to the bacterial ribosomal protein bL27 family
Weevi_1117	COG0261	This protein binds to 23S rRNA in the presence of protein L20
Weevi_1121	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
Weevi_1124	COG0010	Belongs to the arginase family
Weevi_1125	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Weevi_1126	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
Weevi_1127	COG2137	regulation of response to DNA damage stimulus
Weevi_1132	COG0489	protein tyrosine kinase activity
Weevi_1133	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
Weevi_1135	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
Weevi_1139	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
Weevi_1140	COG0527	aspartate kinase activity
Weevi_1144	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
Weevi_1146	COG0756	dUTP diphosphatase activity
Weevi_1150	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Weevi_1152	COG0626	cystathionine gamma-synthase activity
Weevi_1153	COG1506	peptidase
Weevi_1154	COG1187	pseudouridine synthase activity
Weevi_1156	COG1506	peptidase
Weevi_1156	COG0823	Involved in the tonB-independent uptake of proteins
Weevi_1157	COG1530	ribonuclease E activity
Weevi_1158	COG0776	regulation of translation
Weevi_1160	COG0629	single-stranded DNA binding
Weevi_1164	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Weevi_1165	COG0450	alkyl hydroperoxide reductase
Weevi_1167	COG1505	serine-type exopeptidase activity
Weevi_1170	COG2151	metal-sulfur cluster biosynthetic enzyme
Weevi_1173	COG0745	RESPONSE REGULATOR receiver
Weevi_1174	COG5002	protein histidine kinase activity
Weevi_1176	COG0495	leucyl-tRNA aminoacylation
Weevi_1183	COG1250	3-hydroxyacyl-CoA dehydrogenase
Weevi_1184	COG0673	inositol 2-dehydrogenase activity
Weevi_1185	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
Weevi_1189	COG2986	histidine ammonia-lyase
Weevi_1190	COG0302	gtp cyclohydrolase
Weevi_1191	COG0215	cysteine-tRNA ligase activity
Weevi_1192	COG4206	TonB-dependent receptor
Weevi_1192	COG1629	transport
Weevi_1200	COG0356	it plays a direct role in the translocation of protons across the membrane
Weevi_1201	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Weevi_1202	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
Weevi_1203	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Weevi_1204	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
Weevi_1205	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
Weevi_1208	COG4206	TonB-dependent receptor
Weevi_1210	COG0488	(ABC) transporter
Weevi_1227	COG0492	ferredoxin-NADP+ reductase activity
Weevi_1229	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Weevi_1229	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Weevi_1232	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
Weevi_1233	COG1127	ABC transporter
Weevi_1236	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
Weevi_1239	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
Weevi_1242	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
Weevi_1243	COG0488	(ABC) transporter
Weevi_1244	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
Weevi_1244	COG0284	orotidine-5'-phosphate decarboxylase activity
Weevi_1246	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
Weevi_1247	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Weevi_1252	COG0357	Ribosomal RNA small subunit methyltransferase G
Weevi_1253	COG0187	DNA topoisomerase II activity
Weevi_1255	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
Weevi_1257	COG0220	tRNA (guanine-N7-)-methyltransferase activity
Weevi_1261	COG0668	transmembrane transport
Weevi_1263	COG0343	queuine tRNA-ribosyltransferase activity
Weevi_1265	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
Weevi_1266	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
Weevi_1267	COG0291	Belongs to the bacterial ribosomal protein bL35 family
Weevi_1268	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
Weevi_1269	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
Weevi_1269	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
Weevi_1271	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
Weevi_1273	COG2733	membrane
Weevi_1275	COG0463	Glycosyl transferase, family 2
Weevi_1278	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
Weevi_1278	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
Weevi_1279	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
Weevi_1281	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
Weevi_1284	COG0673	inositol 2-dehydrogenase activity
Weevi_1285	COG1607	acyl-coa hydrolase
Weevi_1286	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
Weevi_1294	COG3842	ATPase activity
Weevi_1296	COG0596	Alpha beta hydrolase
Weevi_1297	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
Weevi_1298	COG0668	transmembrane transport
Weevi_1300	COG0779	Required for maturation of 30S ribosomal subunits
Weevi_1301	COG0195	Participates in both transcription termination and antitermination
Weevi_1302	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
Weevi_1303	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
Weevi_1305	COG0285	dihydrofolate synthase activity
Weevi_1306	COG0542	response to heat
Weevi_1309	COG1045	serine acetyltransferase
Weevi_1311	COG1132	(ABC) transporter
Weevi_1315	COG1490	D-aminoacyl-tRNA deacylase activity
Weevi_1316	COG1162	GTPase activity
Weevi_1317	COG2877	3-deoxy-8-phosphooctulonate synthase activity
Weevi_1318	COG1131	(ABC) transporter
Weevi_1319	COG0012	GTP binding
Weevi_1328	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
Weevi_1329	COG0739	heme binding
Weevi_1330	COG0789	Transcriptional regulator
Weevi_1330	COG4978	Transcriptional regulator
Weevi_1332	COG3118	belongs to the thioredoxin family
Weevi_1334	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
Weevi_1335	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
Weevi_1337	COG0321	lipoyl(octanoyl) transferase activity
Weevi_1337	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
Weevi_1343	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
Weevi_1347	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Weevi_1348	COG0793	Belongs to the peptidase S41A family
Weevi_1349	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
Weevi_1351	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
Weevi_1352	COG0230	Belongs to the bacterial ribosomal protein bL34 family
Weevi_1353	COG2884	Cell division ATP-binding protein ftsE
Weevi_1356	COG0438	transferase activity, transferring glycosyl groups
Weevi_1358	COG2877	3-deoxy-8-phosphooctulonate synthase activity
Weevi_1359	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Weevi_1361	COG0563	adenylate kinase activity
Weevi_1369	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
Weevi_1370	COG0049	tRNA binding
Weevi_1371	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Weevi_1372	COG0051	transcription antitermination factor activity, RNA binding
Weevi_1373	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
Weevi_1374	COG0088	Forms part of the polypeptide exit tunnel
Weevi_1375	COG0089	rRNA binding
Weevi_1376	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
Weevi_1377	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
Weevi_1378	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
Weevi_1379	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
Weevi_1380	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
Weevi_1382	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
Weevi_1383	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
Weevi_1384	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
Weevi_1385	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
Weevi_1386	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
Weevi_1387	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Weevi_1388	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
Weevi_1389	COG0351	phosphomethylpyrimidine kinase
Weevi_1391	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
Weevi_1392	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
Weevi_1393	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
Weevi_1394	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
Weevi_1395	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
Weevi_1396	COG1841	ribosomal large subunit assembly
Weevi_1397	COG0200	Binds to the 23S rRNA
Weevi_1398	COG0201	protein transport
Weevi_1399	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
Weevi_1400	COG0257	Belongs to the bacterial ribosomal protein bL36 family
Weevi_1401	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
Weevi_1402	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
Weevi_1403	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
Weevi_1404	COG0202	RNA polymerase activity
Weevi_1405	COG0203	ribosomal protein L17
Weevi_1413	COG0443	Heat shock 70 kDa protein
Weevi_1416	COG0517	IMP dehydrogenase activity
Weevi_1416	COG0516	GMP reductase activity
Weevi_1421	COG3842	ATPase activity
Weevi_1423	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
Weevi_1425	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
Weevi_1426	COG0300	oxidoreductase activity
Weevi_1428	COG0697	spore germination
Weevi_1429	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Weevi_1430	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
Weevi_1434	COG0433	COG0433 Predicted ATPase
Weevi_1435	COG0322	excinuclease ABC activity
Weevi_1436	COG0232	Belongs to the dGTPase family. Type 2 subfamily
Weevi_1441	COG0247	lactate metabolic process
Weevi_1441	COG2181	nitrate reductase activity
Weevi_1442	COG2181	nitrate reductase activity
Weevi_1442	COG0247	lactate metabolic process
Weevi_1444	COG0860	N-Acetylmuramoyl-L-alanine amidase
Weevi_1448	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
Weevi_1450	COG0333	Belongs to the bacterial ribosomal protein bL32 family
Weevi_1451	COG0511	ligase activity, forming carbon-carbon bonds
Weevi_1452	COG0439	Biotin carboxylase
Weevi_1453	COG0544	peptidyl-prolyl cis-trans isomerase activity
Weevi_1455	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
Weevi_1459	COG0772	Belongs to the SEDS family
Weevi_1460	COG0768	penicillin binding
Weevi_1463	COG1077	Cell shape determining protein MreB Mrl
Weevi_1464	COG0616	signal peptide processing
Weevi_1465	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
Weevi_1465	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Weevi_1468	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
Weevi_1470	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Weevi_1472	COG0791	NLP P60 protein
Weevi_1473	COG0339	signal peptide processing
Weevi_1475	COG0815	Transfers the fatty acyl group on membrane lipoproteins
Weevi_1476	COG0227	Belongs to the bacterial ribosomal protein bL28 family
Weevi_1477	COG0267	Belongs to the bacterial ribosomal protein bL33 family
Weevi_1479	COG0552	protein localization to endoplasmic reticulum
Weevi_1484	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
Weevi_1489	COG1702	phosphate starvation-inducible protein PhoH
Weevi_1490	COG0606	chelatase, subunit chli
Weevi_1492	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
Weevi_1495	COG1595	DNA-templated transcription, initiation
Weevi_1498	COG2264	protein methyltransferase activity
Weevi_1499	COG0149	triose-phosphate isomerase activity
Weevi_1500	COG0601	transmembrane transport
Weevi_1503	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
Weevi_1505	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
Weevi_1506	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
Weevi_1506	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Weevi_1507	COG2816	NAD+ diphosphatase activity
Weevi_1511	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Weevi_1513	COG0148	phosphopyruvate hydratase activity
Weevi_1516	COG0628	permease
Weevi_1518	COG4152	abc transporter atp-binding protein
Weevi_1519	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
Weevi_1523	COG0018	arginyl-trna synthetase
Weevi_1525	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
Weevi_1527	COG2195	Cleaves the N-terminal amino acid of tripeptides
Weevi_1529	COG1595	DNA-templated transcription, initiation
Weevi_1531	COG0205	6-phosphofructokinase activity
Weevi_1533	COG1363	Peptidase, m42
Weevi_1534	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
Weevi_1536	COG0151	Belongs to the GarS family
Weevi_1538	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
Weevi_1539	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Weevi_1540	COG0052	Belongs to the universal ribosomal protein uS2 family
Weevi_1541	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
Weevi_1544	COG1132	(ABC) transporter
Weevi_1545	COG0101	tRNA pseudouridine synthase activity
Weevi_1548	COG2986	histidine ammonia-lyase
Weevi_1549	COG1028	Short-chain dehydrogenase reductase Sdr
Weevi_1550	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Weevi_1551	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Weevi_1554	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Weevi_1559	COG1131	(ABC) transporter
Weevi_1562	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Weevi_1564	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Weevi_1565	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Weevi_1571	COG1216	Glycosyl transferase, family 2
Weevi_1573	COG0644	oxidoreductase
Weevi_1577	COG0482	sulfurtransferase activity
Weevi_1581	COG0006	proline dipeptidase activity
Weevi_1582	COG0360	Binds together with S18 to 16S ribosomal RNA
Weevi_1583	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
Weevi_1584	COG0359	binds to the 23S rRNA
Weevi_1586	COG1234	tRNA 3'-trailer cleavage
Weevi_1587	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
Weevi_1589	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
Weevi_1590	COG1295	ribonuclease BN
Weevi_1591	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Weevi_1592	COG1090	epimerase
Weevi_1595	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
Weevi_1598	COG0534	Mate efflux family protein
Weevi_1600	COG1131	(ABC) transporter
Weevi_1602	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
Weevi_1604	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
Weevi_1608	COG0217	transcriptional regulatory protein
Weevi_1611	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
Weevi_1613	COG0745	RESPONSE REGULATOR receiver
Weevi_1614	COG1597	lipid kinase activity
Weevi_1616	COG0047	phosphoribosylformylglycinamidine synthase activity
Weevi_1616	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Weevi_1618	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
Weevi_1619	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
Weevi_1620	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
Weevi_1621	COG0009	L-threonylcarbamoyladenylate synthase
Weevi_1622	COG3022	response to hydroperoxide
Weevi_1626	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
Weevi_1626	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Weevi_1627	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Weevi_1627	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Weevi_1628	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
Weevi_1628	COG0140	phosphoribosyl-ATP diphosphatase activity
Weevi_1630	COG3011	Protein conserved in bacteria
Weevi_1637	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Weevi_1640	COG2204	response regulator
Weevi_1646	COG1678	Uncharacterized ACR, COG1678
Weevi_1647	COG0259	pyridoxamine-phosphate oxidase activity
Weevi_1648	COG0776	regulation of translation
Weevi_1649	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
Weevi_1650	COG0514	ATP-dependent DNA helicase (RecQ)
Weevi_1651	COG1770	oligopeptidase
Weevi_1653	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
Weevi_1654	COG0561	phosphatase activity
Weevi_1655	COG0861	Integral membrane protein TerC family
Weevi_1658	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Weevi_1660	COG0564	pseudouridine synthase activity
Weevi_1661	COG0037	tRNA processing
Weevi_1663	COG0518	GMP synthase (glutamine-hydrolyzing) activity
Weevi_1663	COG0519	Catalyzes the synthesis of GMP from XMP
Weevi_1665	COG1595	DNA-templated transcription, initiation
Weevi_1666	COG0791	NLP P60 protein
Weevi_1671	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
Weevi_1672	COG0531	amino acid
Weevi_1673	COG2234	aminopeptidase activity
Weevi_1674	COG3340	Belongs to the peptidase S51 family
Weevi_1675	COG2824	Alkylphosphonate utilization operon protein PhnA
Weevi_1678	COG0642	Histidine kinase
Weevi_1682	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Weevi_1684	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Weevi_1687	COG0653	protein targeting
Weevi_1692	COG0436	Aminotransferase
Weevi_1693	COG0812	UDP-N-acetylmuramate dehydrogenase activity
Weevi_1694	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
Weevi_1695	COG1663	tetraacyldisaccharide 4'-kinase activity
Weevi_1696	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
Weevi_1697	COG0069	glutamate synthase activity
Weevi_1698	COG0747	negative chemotaxis
Weevi_1699	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Weevi_1704	COG1472	Belongs to the glycosyl hydrolase 3 family
Weevi_1705	COG0438	transferase activity, transferring glycosyl groups
Weevi_1706	COG3186	Phenylalanine-4-hydroxylase
Weevi_1707	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
Weevi_1708	COG3876	Protein conserved in bacteria
Weevi_1711	COG1137	ATPase activity
Weevi_1712	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
Weevi_1715	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
Weevi_1719	COG0494	nUDIX hydrolase
Weevi_1724	COG2921	Belongs to the UPF0250 family
Weevi_1726	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
Weevi_1728	COG1522	sequence-specific DNA binding
Weevi_1731	COG1760	l-serine dehydratase
Weevi_1734	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
Weevi_1736	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Weevi_1736	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Weevi_1739	COG0612	Peptidase, M16
Weevi_1744	COG0437	4 iron, 4 sulfur cluster binding
Weevi_1751	COG0739	heme binding
Weevi_1753	COG0242	peptide deformylase activity
Weevi_1754	COG2259	Doxx family
Weevi_1757	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
Weevi_1759	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Weevi_1762	COG3023	N-Acetylmuramoyl-L-alanine amidase
Weevi_1765	COG2356	endonuclease I
Weevi_1766	COG1649	PFAM Uncharacterised BCR, COG1649
Weevi_1776	COG1741	Belongs to the pirin family
Weevi_1777	COG2217	Heavy metal translocating P-type atpase
Weevi_1780	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
Weevi_1781	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
Weevi_1786	COG1960	acyl-CoA dehydrogenase activity
Weevi_1788	COG2226	methyltransferase
Weevi_1790	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Weevi_1791	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
Weevi_1794	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
Weevi_1795	COG4651	solute:proton antiporter activity
Weevi_1795	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
Weevi_1797	COG0492	ferredoxin-NADP+ reductase activity
Weevi_1802	COG1185	polyribonucleotide nucleotidyltransferase activity
Weevi_1803	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
Weevi_1804	COG0488	(ABC) transporter
Weevi_1806	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Weevi_1809	COG1289	transmembrane transporter activity
Weevi_1813	COG0572	uridine kinase
Weevi_1815	COG1946	Acyl-CoA thioesterase
Weevi_1819	COG1022	Amp-dependent synthetase and ligase
Weevi_1828	COG2814	Major facilitator Superfamily
Weevi_1830	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Weevi_1831	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Weevi_1832	COG0671	phosphoesterase, PA-phosphatase related
Weevi_1833	COG1271	oxidase subunit
Weevi_1840	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
Weevi_1843	COG0300	oxidoreductase activity
Weevi_1844	COG1120	ATPase activity
Weevi_1845	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Weevi_1848	COG1629	transport
Weevi_1848	COG4206	TonB-dependent receptor
Weevi_1851	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
Weevi_1854	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
Weevi_1856	COG2135	peptidase activity
Weevi_1857	COG1193	negative regulation of DNA recombination
Weevi_1858	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
Weevi_1859	COG0300	oxidoreductase activity
Weevi_1863	COG4771	TonB-dependent receptor
Weevi_1865	COG0525	valine-tRNA ligase activity
Weevi_1866	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Weevi_1866	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Weevi_1870	COG4206	TonB-dependent receptor
Weevi_1871	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Weevi_1876	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
Weevi_1877	COG1250	3-hydroxyacyl-CoA dehydrogenase
Weevi_1877	COG1024	Enoyl-CoA hydratase
Weevi_1881	COG0484	heat shock protein binding
Weevi_1882	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
Weevi_1884	COG0739	heme binding
Weevi_1887	COG1418	mRNA catabolic process
Weevi_1888	COG0006	proline dipeptidase activity
Weevi_1890	COG2176	DNA-directed DNA polymerase activity
Weevi_1891	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
Weevi_1900	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
Weevi_1903	COG1528	Iron-storage protein
Weevi_1905	COG1607	acyl-coa hydrolase
Weevi_1906	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
Weevi_1907	COG1705	Flagellar rod assembly protein muramidase FlgJ
Weevi_1907	COG1388	LysM domain
Weevi_1908	COG2515	1-aminocyclopropane-1-carboxylate deaminase
Weevi_1911	COG1104	cysteine desulfurase activity
Weevi_1913	COG0556	nucleotide-excision repair
Weevi_1914	COG3956	TIGRFAM MazG family protein
Weevi_1916	COG0242	peptide deformylase activity
Weevi_1917	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
Weevi_1918	COG2171	N-acyltransferase activity
Weevi_1919	COG2076	Multidrug Resistance protein
Weevi_1920	COG0523	cobalamin synthesis protein
Weevi_1921	COG1408	metallophosphoesterase
Weevi_1922	COG0142	geranyltranstransferase activity
Weevi_1924	COG0820	rRNA (adenine-C2-)-methyltransferase activity
Weevi_1925	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
Weevi_1927	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
Weevi_1931	COG2356	endonuclease I
Weevi_1932	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Weevi_1935	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
Weevi_1938	COG0183	Belongs to the thiolase family
Weevi_1939	COG0825	malonyl-CoA metabolic process
Weevi_1940	COG0305	Participates in initiation and elongation during chromosome replication
Weevi_1943	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
Weevi_1944	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Weevi_1944	COG3153	acetyltransferase
Weevi_1951	COG1629	transport
Weevi_1951	COG4206	TonB-dependent receptor
Weevi_1960	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
Weevi_1963	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Weevi_1963	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Weevi_1970	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
Weevi_1972	COG0358	DNA primase activity
Weevi_1975	COG0463	Glycosyl transferase, family 2
Weevi_1976	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
Weevi_1979	COG0463	Glycosyl transferase, family 2
Weevi_1979	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
Weevi_1982	COG0617	tRNA 3'-terminal CCA addition
Weevi_1986	COG2226	methyltransferase
Weevi_1990	COG0492	ferredoxin-NADP+ reductase activity
Weevi_1992	COG2217	Heavy metal translocating P-type atpase
Weevi_1993	COG0402	S-adenosylhomocysteine deaminase activity
Weevi_1994	COG1834	amidinotransferase
Weevi_1998	COG0778	Nitroreductase
Weevi_1999	COG1803	Methylglyoxal synthase
Weevi_2001	COG0336	Belongs to the RNA methyltransferase TrmD family
Weevi_2002	COG0113	porphobilinogen synthase activity
Weevi_2003	COG0596	Alpha beta hydrolase
Weevi_2005	COG0564	pseudouridine synthase activity
Weevi_2006	COG0497	DNA recombination
Weevi_2011	COG1528	Iron-storage protein
Weevi_2012	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Weevi_2014	COG0737	Belongs to the 5'-nucleotidase family
Weevi_2015	COG1960	acyl-CoA dehydrogenase activity
Weevi_2016	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Weevi_2017	COG3590	peptidase
Weevi_2018	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Weevi_2019	COG3590	peptidase
Weevi_2021	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
Weevi_2023	COG1575	Belongs to the MenA family. Type 1 subfamily
Weevi_2024	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
Weevi_2029	COG1703	isobutyryl-CoA mutase activity
Weevi_2029	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
Weevi_2029	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
Weevi_2031	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
Weevi_2037	COG4717	serine-type aminopeptidase activity
Weevi_2038	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
Weevi_2039	COG0017	Asparaginyl-tRNA synthetase
Weevi_2041	COG0233	cytoplasmic translational termination
Weevi_2042	COG0528	UMP kinase activity
Weevi_2043	COG0084	hydrolase, TatD family'
Weevi_2046	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Weevi_2054	COG0339	signal peptide processing
Weevi_2062	COG2897	thiosulfate sulfurtransferase activity
Weevi_2063	COG2270	Major facilitator Superfamily
Weevi_2065	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Weevi_2066	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
Weevi_2067	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Weevi_2069	COG0484	heat shock protein binding
Weevi_2070	COG1114	Component of the transport system for branched-chain amino acids
Weevi_2074	COG0156	8-amino-7-oxononanoate synthase activity
Weevi_2076	COG0321	lipoyl(octanoyl) transferase activity
Weevi_2081	COG0667	Aldo Keto reductase
Weevi_2082	COG2814	Major facilitator Superfamily
Weevi_2083	COG1902	pentaerythritol trinitrate reductase activity
Weevi_2084	COG1252	NADH dehydrogenase
Weevi_2085	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Weevi_2088	COG0735	belongs to the Fur family
Weevi_2090	COG1115	amino acid carrier protein
Weevi_2094	COG0681	Belongs to the peptidase S26 family
Weevi_2094	COG0681	Belongs to the peptidase S26 family
Weevi_2095	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
Weevi_2097	COG1475	DNA binding
Weevi_2098	COG1192	Involved in chromosome partitioning
Weevi_2101	COG2066	Belongs to the glutaminase family
Weevi_2105	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
Weevi_R0033	COG1012	belongs to the aldehyde dehydrogenase family