locus-tag	class	description
WS105_0001	ENOG4105VG0	50S ribosomal protein l34
WS105_0002	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
WS105_0003	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
WS105_0004	ENOG410848D	S4 domain protein YaaA
WS105_0005	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
WS105_0006	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
WS105_0007	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
WS105_0013	ENOG4106KNT	transcriptional regulator
WS105_0018	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
WS105_0019	ENOG4105C2W	permease
WS105_0020	ENOG4108UPS	Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity)
WS105_0021	ENOG4105C7Q	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity)
WS105_0022	ENOG4105C7N	Xanthine uracil vitamin C permease
WS105_0028	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
WS105_0030	ENOG4108R3E	Dna-3-methyladenine glycosylase i
WS105_0032	ENOG4105C8T	Leucyl-tRNA synthetase
WS105_0036	ENOG4107R7I	amino acid
WS105_0038	ENOG4105C5N	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
WS105_0039	ENOG4107R2I	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation
WS105_0043	ENOG4108HMR	Key enzyme in the regulation of glycerol uptake and metabolism (By similarity)
WS105_0044	ENOG4105DFT	pur operon repressor
WS105_0045	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
WS105_0046	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
WS105_0047	ENOG4108WQ8	UPF0637 protein
WS105_0048	ENOG4108ZDX	Binds together with S18 to 16S ribosomal RNA (By similarity)
WS105_0049	ENOG4108UUM	single-stranded DNA-binding protein
WS105_0050	ENOG4105VH8	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity)
WS105_0051	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
WS105_0052	ENOG4105BZU	Histidine kinase
WS105_0055	ENOG4105Q2H	domain protein
WS105_0056	ENOG4105C0H	protease
WS105_0058	ENOG4105DCI	Phosphohydrolase
WS105_0059	ENOG410667J	hydrolase
WS105_0060	ENOG4108Z1Y	Participates in both the initiation and recycling phases of transcription. In the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling (By similarity)
WS105_0061	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
WS105_0062	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
WS105_0063	ENOG4105C1J	atp-dependent rna helicase
WS105_0064	ENOG41082V8	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity)
WS105_0065	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
WS105_0066	ENOG4108YZM	Toxic component of a toxin-antitoxin (TA) module (By similarity)
WS105_0067	ENOG4105EEM	helicase
WS105_0069	ENOG4105C9X	ppx gppa phosphatase
WS105_0074	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
WS105_0078	ENOG4105CT1	(ABC) transporter
WS105_0079	ENOG4105EAD	ABC transporter
WS105_0080	ENOG4105DRP	amino acid AbC transporter
WS105_0083	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
WS105_0084	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
WS105_0086	ENOG4108JQ7	(ABC) transporter
WS105_0088	ENOG4105K9Q	Binds to the 23S rRNA (By similarity)
WS105_0089	ENOG4105CDU	Replicative dna helicase
WS105_0090	ENOG410605W	Major Facilitator
WS105_0093	ENOG4105CTR	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity)
WS105_0095	ENOG4105CAY	ferredoxin--nadp reductase
WS105_0096	ENOG4105DKJ	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
WS105_0097	ENOG4105EY8	ABC transporter
WS105_0100	ENOG4107T5V	SNARE associated Golgi
WS105_0103	ENOG4107EES	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity)
WS105_0104	ENOG4105DFF	Rod shape-determining protein mreb
WS105_0106	ENOG4105CNI	cell division protein FtsW
WS105_0107	ENOG4105II7	pyrroline-5-carboxylate reductase
WS105_0108	ENOG4108HCJ	Hydrolase
WS105_0109	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
WS105_0110	ENOG4105CE4	GlcNAc 6-P deacetylase
WS105_0111	ENOG4105FDP	GntR family transcriptional regulator
WS105_0112	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
WS105_0114	ENOG4105C7N	Xanthine uracil vitamin C permease
WS105_0116	ENOG4108UGV	hypoxanthine phosphoribosyltransferase
WS105_0120	ENOG4108HCJ	Hydrolase
WS105_0121	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
WS105_0122	ENOG4105KNE	Phosphatidate cytidylyltransferase
WS105_0123	ENOG4105DZP	Membrane-associated zinc metalloprotease
WS105_0124	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
WS105_0125	ENOG4105DE5	Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity)
WS105_0137	ENOG4105E4Y	Endoribonuclease that initiates mRNA decay (By similarity)
WS105_0140	ENOG4107SJ1	Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity)
WS105_0159	ENOG4105FSR	swimming returnes to normal when residues 206-207 are both mutated to Ala. Overexpression also leads to a reduction in flagellar abundance and a 20-fold increase in c-di- GMP levels in vivo. Required for aminoglycoside-mediated induction of biofilm formation, it also plays a lesser role in biofilm production in response to other classes of translation inhibitors. The c-di-GMP produced by this enzyme up-regulates poly-GlcNAc production as well as the biofilm synthesis protein PgaD, although c-di-GMP is probably not the main inducing principle. Cyclic-di- GMP is a second messenger which controls cell surface-associated traits in bacteria
WS105_0161	ENOG4105BZU	Histidine kinase
WS105_0166	ENOG4105MRB	Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity)
WS105_0167	ENOG4105EV1	Ribose uptake protein RbsU
WS105_0168	ENOG4105KPY	Small multidrug resistance protein
WS105_0169	ENOG4105D64	Mechanosensitive ion channel
WS105_0170	ENOG4105CSC	Glucose uptake protein
WS105_0171	ENOG4107QYV	phosphohexose isomerase
WS105_0172	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
WS105_0173	ENOG4108ZSR	alkaline shock protein
WS105_0174	ENOG4105M7K	Involved in the transcription termination process (By similarity)
WS105_0175	ENOG4108UUX	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity)
WS105_0176	ENOG4105VJV	50s ribosomal protein L35
WS105_0177	ENOG4108YZX	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity)
WS105_0178	ENOG4108UKE	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity)
WS105_0179	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
WS105_0180	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
WS105_0181	ENOG4105D9R	oxidoreductase
WS105_0182	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
WS105_0183	ENOG4105EUS	Binding-protein-dependent transport systems, inner membrane component
WS105_0184	ENOG4105D38	putrescine abc transporter
WS105_0185	ENOG4107RUE	extracellular solute-binding protein family 1
WS105_0186	ENOG4108R5K	PPIases accelerate the folding of proteins (By similarity)
WS105_0187	ENOG41086DT	Membrane protein of unknown function
WS105_0188	ENOG4105D1C	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity)
WS105_0189	ENOG4105CSF	NADPH-dependent glycerol-3-phosphate dehydrogenase
WS105_0191	ENOG4105C3M	thioredoxin reductase
WS105_0193	ENOG4105KRI	phosphocarrier protein (HPr
WS105_0194	ENOG4105BZ3	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity)
WS105_0195	ENOG4105CP7	Triose-phosphate isomerase
WS105_0196	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
WS105_0198	ENOG4105C40	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity)
WS105_0199	ENOG4108UH4	Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity)
WS105_0200	ENOG4105E5Q	amino acid AbC transporter
WS105_0201	ENOG4105CDA	abc transporter atp-binding protein
WS105_0202	ENOG4105D5S	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity)
WS105_0203	ENOG4108IJ2	phosphate acetyltransferase
WS105_0204	ENOG4105K8N	protein family UPF0079, ATPase
WS105_0206	ENOG4105DE5	Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity)
WS105_0207	ENOG4105D4A	Cell wall formation (By similarity)
WS105_0210	ENOG4107QJF	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity)
WS105_0212	ENOG4105CXT	aspartate transcarbamylase
WS105_0213	ENOG4105CD3	dihydroorotase
WS105_0214	ENOG4105C1M	carbamoyl-phosphate synthetase glutamine chain
WS105_0215	ENOG4105CU6	carbamoyl-phosphate synthetase ammonia chain
WS105_0216	ENOG4106EG9	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity)
WS105_0217	ENOG41065E1	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
WS105_0218	ENOG4105BZF	Glycosyl transferase (Group 1
WS105_0219	ENOG4105W2C	Glycosyl transferase
WS105_0221	ENOG4105E0M	Sulfatase
WS105_0222	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
WS105_0223	ENOG4107SUZ	Sodium/hydrogen exchanger family
WS105_0224	ENOG4105F8V	Hydrolase, tatD family
WS105_0225	ENOG4105HVR	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity)
WS105_0227	ENOG4105C37	(CBS) domain
WS105_0228	ENOG4108UK2	deaminase
WS105_0229	ENOG4105C0V	Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity)
WS105_0230	ENOG4108KGH	TRANSCRIPTIONal
WS105_0231	ENOG41067S9	phage shock protein C, PspC
WS105_0232	ENOG4105DWR	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity)
WS105_0233	ENOG4107S2Z	UPF0761 membrane protein
WS105_0236	ENOG4108ZPD	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity)
WS105_0237	ENOG4108JA2	transcriptioN-repair coupling factor
WS105_0239	ENOG41082I2	s4 domain protein
WS105_0242	ENOG4108UGV	hypoxanthine phosphoribosyltransferase
WS105_0245	ENOG4105CRK	lysyL-tRNA synthetase
WS105_0250	ENOG4105C4M	(Ubiquinol oxidase) subunit I
WS105_0251	ENOG4105CFY	cytochrome d ubiquinol oxidase, subunit ii
WS105_0252	ENOG4108JJ9	ABC, transporter
WS105_0253	ENOG4108JJ8	(ABC) transporter
WS105_0254	ENOG4108ZW7	flagellar rod assembly protein muramidase flgj
WS105_0260	ENOG4105VEQ	Cold shock protein
WS105_0261	ENOG4108YZ4	nudix hydrolase
WS105_0263	ENOG4105DUF	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity)
WS105_0267	ENOG4105WAZ	(Glutaredoxin-like protein) NrdH
WS105_0268	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
WS105_0269	ENOG4105E05	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
WS105_0271	ENOG4105C7J	ABC transporter, permease
WS105_0272	ENOG4105E2Y	ABC, transporter
WS105_0276	ENOG4105W5Q	DNA repair protein (RadC
WS105_0277	ENOG4105DFF	Rod shape-determining protein mreb
WS105_0278	ENOG4105N3I	Involved in formation and maintenance of cell shape (By similarity)
WS105_0281	ENOG4105E5Q	amino acid AbC transporter
WS105_0283	ENOG4105E89	ABC transporter
WS105_0284	ENOG4105CKU	formyltetrahydrofolate synthetase
WS105_0289	ENOG4108IQI	permease
WS105_0290	ENOG4105CA9	Pyruvate kinase
WS105_0291	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
WS105_0292	ENOG4107TVK	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity)
WS105_0293	ENOG4108V6E	Cell division protein mraZ
WS105_0296	ENOG4105CJN	penicillin-binding protein
WS105_0298	ENOG4105DMZ	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity)
WS105_0299	ENOG4105DVQ	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity)
WS105_0300	ENOG4108W8M	Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity)
WS105_0301	ENOG4105CIT	This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity)
WS105_0302	ENOG4105CDK	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity)
WS105_0303	ENOG4105VR5	Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity)
WS105_0304	ENOG41067XK	integral membrane protein
WS105_0305	ENOG4105DBK	s4 domain protein
WS105_0307	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
WS105_0310	ENOG4105C7H	Helicase, RecD TraA family
WS105_0311	ENOG4105CDY	transcriptional regulatory protein
WS105_0314	ENOG4106855	Competence protein
WS105_0317	ENOG4105C25	Primosomal protein n'
WS105_0318	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
WS105_0319	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
WS105_0321	ENOG4105D9P	serine threonine protein kinase
WS105_0322	ENOG4105E06	May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity)
WS105_0323	ENOG4105DJV	ribulose-phosphate 3-epimerase
WS105_0325	ENOG4105VB9	50S ribosomal protein l28
WS105_0327	ENOG4105DP4	dak2 domain fusion protein ylov
WS105_0328	ENOG4105CB5	ATP-dependent DNA helicase recG
WS105_0329	ENOG4105C6B	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity)
WS105_0330	ENOG4105VNB	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
WS105_0331	ENOG4108ZBM	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity)
WS105_0332	ENOG4105CDB	Required for chromosome condensation and partitioning (By similarity)
WS105_0333	ENOG4105CCP	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
WS105_0335	ENOG4105CB9	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
WS105_0336	ENOG4105K5M	30s ribosomal protein S16
WS105_0337	ENOG4107Z8R	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity)
WS105_0338	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
WS105_0339	ENOG4108YY1	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity)
WS105_0340	ENOG4107AYK	membrAne
WS105_0341	ENOG41069HH	4-oxalocrotonate tautomerase
WS105_0343	ENOG4105M6F	mutator MutT protein
WS105_0344	ENOG4105ZMH	deoxynucleoside kinase
WS105_0345	ENOG4105M2E	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity)
WS105_0346	ENOG410667J	hydrolase
WS105_0350	ENOG4108VY7	phosphate-starvation-inducible protein PsiE
WS105_0351	ENOG4108SQ7	Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis
WS105_0355	ENOG4105DC7	peptidase M24
WS105_0356	ENOG4105ETE	Transcriptional regulator (LacI family
WS105_0360	ENOG4105CJS	Phosphopantothenoylcysteine decarboxylase
WS105_0361	ENOG4105F99	Hydroxymethylglutaryl-CoA synthase
WS105_0363	ENOG4105C5C	n-acetylmuramoyl-l-alanine amidase
WS105_0364	ENOG4105CUT	histidyl-tRNA synthetase
WS105_0365	ENOG4105C9M	aspartyl-trna synthetase
WS105_0366	ENOG4107AYK	membrAne
WS105_0368	ENOG4105KTH	gatB Yqey
WS105_0369	ENOG4105KGE	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity)
WS105_0370	ENOG4107YR5	Diacylglycerol kinase
WS105_0371	ENOG4105CWT	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity)
WS105_0372	ENOG4108SAY	Involved in DNA repair and RecF pathway recombination (By similarity)
WS105_0373	ENOG4108HMW	glycyl-tRNA synthetase, alpha subunit
WS105_0374	ENOG4105C38	Glycyl-tRNA synthetase beta subunit
WS105_0376	ENOG4105D2N	Aldolase
WS105_0377	ENOG4105D8C	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity)
WS105_0378	ENOG4105DAA	L-lactate
WS105_0380	ENOG4105DU1	integral membrane protein, terc
WS105_0381	ENOG4105HHQ	6-phosphogluconolactonase (EC 3.1.1.31)
WS105_0382	ENOG4108UIQ	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity)
WS105_0383	ENOG4105CNU	cell division protein FtsK
WS105_0384	ENOG4108IUX	(ABC) transporter
WS105_0385	ENOG4105RHA	ABC transporter, permease
WS105_0386	ENOG4107T6V	glycerophosphoryl diester phosphodiesterase
WS105_0388	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
WS105_0389	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
WS105_0391	ENOG4108ZK7	protein family UPF0029, Impact, N-terminal protein
WS105_0392	ENOG4105C6X	Major Facilitator
WS105_0393	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
WS105_0394	ENOG4105KA4	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity)
WS105_0396	ENOG4105VIE	preprotein translocase, subunit YajC
WS105_0397	ENOG4105CQ3	Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity)
WS105_0398	ENOG4105SFS	phosphoesterase RecJ domain protein
WS105_0399	ENOG4105C1J	atp-dependent rna helicase
WS105_0400	ENOG4108UW5	maltose o-acetyltransferase
WS105_0401	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
WS105_0403	ENOG4108Z08	Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity)
WS105_0404	ENOG4105VPH	UPF0473 protein
WS105_0405	ENOG4105VPH	UPF0473 protein
WS105_0406	ENOG41083P1	competence protein ComEA helix-hairpin-helix repeat protein
WS105_0407	ENOG4105EGY	DNA internalization-related competence protein ComEC Rec2
WS105_0408	ENOG4105TQK	DNA polymerase iii, delta' subunit
WS105_0409	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
WS105_0410	ENOG4105KQV	Binds directly to 16S ribosomal RNA (By similarity)
WS105_0414	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
WS105_0415	ENOG4105DEA	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation
WS105_0416	ENOG4105CHN	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
WS105_0417	ENOG4105WHM	Necessary for normal cell division and for the maintenance of normal septation (By similarity)
WS105_0420	ENOG4105C98	muts2 protein
WS105_0422	ENOG4105K63	Thioredoxin
WS105_0423	ENOG4105F03	Provides the (R)-glutamate required for cell wall biosynthesis (By similarity)
WS105_0424	ENOG4108V82	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
WS105_0427	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
WS105_0428	ENOG4105EMS	pseudouridine synthase
WS105_0429	ENOG4105CJW	magnesium transporter
WS105_0430	ENOG4105K7D	Required for maturation of 30S ribosomal subunits (By similarity)
WS105_0431	ENOG4105CHV	Transcription elongation factor NusA
WS105_0432	ENOG4105VZN	Nucleic-acid-binding protein implicated in transcription termination
WS105_0434	ENOG4107EEM	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
WS105_0435	ENOG4105KG7	Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity)
WS105_0436	ENOG4108MK9	spermidine N(1)-acetyltransferase
WS105_0437	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
WS105_0439	ENOG4105DTN	riboflavin biosynthesis protein ribF
WS105_0440	ENOG4105F23	Fibronectin-binding protein
WS105_0441	ENOG4106N3A	copper homeostasis protein cutc
WS105_0442	ENOG4105EPR	degv family
WS105_0443	ENOG4108RCR	degv family
WS105_0444	ENOG4105CXG	d-lactate dehydrogenase
WS105_0445	ENOG4106E6V	UPF0346 protein
WS105_0446	ENOG4105C9W	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity)
WS105_0447	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
WS105_0448	ENOG4106432	Mediates binding to human platelets, possibly through a receptor-ligand interaction. Probably associated with virulence in endovascular infection (By similarity)
WS105_0451	ENOG4105C79	DNA protecting protein DprA
WS105_0452	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
WS105_0453	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
WS105_0456	ENOG4105F27	Major Facilitator
WS105_0457	ENOG4105K7Z	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity)
WS105_0458	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
WS105_0459	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
WS105_0463	ENOG4105E2M	Manganese-dependent inorganic pyrophosphatase
WS105_0465	ENOG4108IJ7	Glycine betaine
WS105_0473	ENOG4105KWG	Pfam:DUF1696
WS105_0477	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
WS105_0478	ENOG4105WBI	UPF0223 protein
WS105_0479	ENOG4105ECY	inositol monophosphatase
WS105_0480	ENOG4105CI3	gtp-binding protein typa
WS105_0481	ENOG4105CNI	cell division protein FtsW
WS105_0482	ENOG4105WUC	UPF0298 protein
WS105_0483	ENOG4106H78	methyltransferase
WS105_0484	ENOG4108ZEF	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)
WS105_0485	ENOG41063PX	domain protein
WS105_0486	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
WS105_0487	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
WS105_0488	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
WS105_0490	ENOG4105DPZ	Two component transcriptional regulator (Winged helix family
WS105_0491	ENOG4105BZU	Histidine kinase
WS105_0493	ENOG4108VDD	TRNA binding domain protein
WS105_0495	ENOG4105DFU	Cell wall formation (By similarity)
WS105_0496	ENOG4105HFZ	Membrane
WS105_0500	ENOG4105ERD	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity)
WS105_0501	ENOG4108ZQD	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity)
WS105_0506	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
WS105_0507	ENOG4105GR3	Histidine kinase
WS105_0509	ENOG4107SC7	Inner membrane transporter yjeM
WS105_0510	ENOG4108WCX	response regulator
WS105_0513	ENOG4105C28	cystathionine
WS105_0518	ENOG4107PP3	Acetylornithine deacetylase
WS105_0520	ENOG4105C5H	ABC transporter
WS105_0533	ENOG4105CQ3	Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity)
WS105_0536	ENOG4105DZW	Dipeptidase
WS105_0537	ENOG4108TYN	CAAX amino terminal protease family protein
WS105_0553	ENOG4105K64	Glycosyl transferase, family 2
WS105_0554	ENOG4108UT2	hemolysin iii
WS105_0557	ENOG4107QTG	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity)
WS105_0558	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
WS105_0559	ENOG4108YXN	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity)
WS105_0561	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
WS105_0562	ENOG4105CHR	reductase
WS105_0563	ENOG4108JA1	polyketide synthase
WS105_0566	ENOG410854A	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
WS105_0567	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
WS105_0569	ENOG4108YXN	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity)
WS105_0570	ENOG4105EXC	Acyl-transferase
WS105_0573	ENOG4107QMW	pyridine nucleotide-disulfide oxidoreductase
WS105_0577	ENOG4108UV6	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity)
WS105_0578	ENOG4105DWF	phosphomethylpyrimidine kinase
WS105_0579	ENOG4105C4U	4-methyl-5-beta-hydroxyethylthiazole kinase
WS105_0580	ENOG4105CPN	adenine deaminase
WS105_0582	ENOG4107VXM	glycerophosphoryl diester phosphodiesterase
WS105_0585	ENOG4108HCJ	Hydrolase
WS105_0586	ENOG4106TD9	Diguanylate cyclase
WS105_0589	ENOG4105CZ1	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity)
WS105_0592	ENOG4105K59	histidine triad (HIT) protein
WS105_0594	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
WS105_0598	ENOG4105C4R	Atp-dependent dna helicase
WS105_0602	ENOG4108CHM	Preferentially cleaves peptide bonds on the carboxyl- terminal side of aspartate and glutamate. Along with other extracellular proteases it is involved in colonization and infection of human tissues. Required for proteolytic maturation of thiol protease SspB and inactivation of SspC, an inhibitor of SspB. It is the most important protease for degradation of fibronectin-binding protein (FnBP) and surface protein A, which are involved in adherence to host cells. May also protect bacteria against host defense mechanism by cleaving the immunoglobulin classes IgG, IgA and IgM. May be involved in the stability of secreted lipases
WS105_0620	ENOG41060R1	head morphogenesis protein, SPP1 gp7
WS105_0622	ENOG4105IG6	Phage terminase, large subunit
WS105_0641	ENOG41067VN	Glutaredoxin
WS105_0647	ENOG4108JA2	transcriptioN-repair coupling factor
WS105_0658	ENOG4106050	phage regulatory protein, rha family
WS105_0665	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
WS105_0666	ENOG4105C4H	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity)
WS105_0667	ENOG4105XWG	Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation (By similarity)
WS105_0668	ENOG4108UKS	UPF0398 protein
WS105_0669	ENOG4108UI2	Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity)
WS105_0675	ENOG4105C5S	asparaginyl-tRNA synthetase
WS105_0677	ENOG4105DVT	helicase
WS105_0678	ENOG4107BMA	Transglycosylase associated protein
WS105_0694	ENOG4106UJV	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity)
WS105_0696	ENOG4107XQC	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins (By similarity)
WS105_0698	ENOG4108UGX	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity)
WS105_0700	ENOG4107R7I	amino acid
WS105_0702	ENOG4105HMI	Membrane
WS105_0704	ENOG4105CND	Glycosyl transferase, family 2
WS105_0706	ENOG4105CHU	acetyl-coa acetyltransferase
WS105_0708	ENOG4105G5W	regulator Fur family
WS105_0710	ENOG4105C4B	ABC transporter, permease
WS105_0711	ENOG41083J0	(ABC) transporter
WS105_0712	ENOG41067V2	Esterase lipase
WS105_0713	ENOG4107RHR	regulatoR
WS105_0715	ENOG4105C19	ABC transporter
WS105_0717	ENOG4107QN2	dihydrolipoyl dehydrogenase
WS105_0719	ENOG4105CPP	Dehydrogenase, E1 component
WS105_0721	ENOG4105DF9	Lipoate-protein, ligase
WS105_0722	ENOG4105CG3	alpha amylase, catalytic region
WS105_0725	ENOG4105KNA	-acetyltransferase
WS105_0729	ENOG4105TPC	MazG nucleotide pyrophosphohydrolase domain
WS105_0730	ENOG4108URH	decarboxylase
WS105_0735	ENOG4105FKQ	transcriptional regulator
WS105_0737	ENOG4105CKU	formyltetrahydrofolate synthetase
WS105_0738	ENOG4105C12	Phosphoribosylglycinamide synthetase
WS105_0739	ENOG4105DC1	bifunctional purine biosynthesis protein purh
WS105_0740	ENOG4108V3E	phosphoribosylglycinamide formyltransferase
WS105_0741	ENOG4105CXB	phosphoribosylaminoimidazole synthetase
WS105_0743	ENOG4108JIU	phosphoribosylformylglycinamidine synthase ii
WS105_0744	ENOG4105D21	Phosphoribosylformylglycinamidine synthase I
WS105_0746	ENOG4105C8V	SAICAR synthetase
WS105_0747	ENOG4105CY8	phosphoribosylaminoimidazole carboxylase atpase subunit
WS105_0748	ENOG4108UM6	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity)
WS105_0749	ENOG4108M4D	D-alanyl-lipoteichoic acid biosynthesis protein DltD
WS105_0750	ENOG4105X96	Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Activated D-alanyl-Dcp donates its D-alanyl substituent to membrane-associated LTA (By similarity)
WS105_0751	ENOG4105CK0	Membrane bOund o-acyl transferase mboat family protein
WS105_0752	ENOG4108IQD	Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity)
WS105_0755	ENOG4106KNP	GTP-binding protein LepA C-terminus
WS105_0759	ENOG4108QHG	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity)
WS105_0760	ENOG4105KPE	licD family
WS105_0763	ENOG4105DC8	reductase
WS105_0765	ENOG41082QR	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
WS105_0769	ENOG4105C6H	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity)
WS105_0770	ENOG4105D42	Cleaves the N-terminal amino acid of tripeptides (By similarity)
WS105_0771	ENOG4105EGD	dinuclear metal center protein, YbgI family
WS105_0773	ENOG41068YB	TPR repeat-containing protein
WS105_0779	ENOG4105DJ2	Major Facilitator Superfamily
WS105_0780	ENOG4105PUK	Membrane
WS105_0781	ENOG4105DWF	phosphomethylpyrimidine kinase
WS105_0783	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
WS105_0784	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
WS105_0785	ENOG4105CAT	Cytidine monophosphate kinase
WS105_0787	ENOG4105C9U	ATP-dependent DNA helicase RecQ
WS105_0790	ENOG4108SAX	Membrane
WS105_0791	ENOG4105FE9	pseudouridine synthase
WS105_0792	ENOG4105K8I	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity)
WS105_0793	ENOG4108KVX	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity)
WS105_0796	ENOG4105QNR	S1 RNA binding domain protein
WS105_0798	ENOG4105D8C	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity)
WS105_0799	ENOG4105CP7	Triose-phosphate isomerase
WS105_0800	ENOG4105C6V	Glycerol-3-phosphate dehydrogenase
WS105_0801	ENOG4108HMR	Key enzyme in the regulation of glycerol uptake and metabolism (By similarity)
WS105_0806	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
WS105_0807	ENOG4105C0B	DNA polymerase III (alpha subunit)
WS105_0810	ENOG4105C5H	ABC transporter
WS105_0811	ENOG4105D4J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
WS105_0814	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
WS105_0817	ENOG4108KGH	TRANSCRIPTIONal
WS105_0818	ENOG4108VCV	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity)
WS105_0819	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
WS105_0820	ENOG4105CU7	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity)
WS105_0823	ENOG4105VC4	domain protein
WS105_0824	ENOG41060K3	Methyltransferase
WS105_0825	ENOG4105F6E	Acyl-transferase
WS105_0826	ENOG4105VXM	UPF0154 protein
WS105_0827	ENOG4105VPS	UPF0291 protein
WS105_0828	ENOG4109003	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity)
WS105_0829	ENOG4105C2R	Single-stranded-DNA-specific exonuclease (RecJ)
WS105_0833	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
WS105_0834	ENOG4105CFG	Acts as a chaperone (By similarity)
WS105_0835	ENOG4105K90	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
WS105_0836	ENOG4105CI8	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity)
WS105_0839	ENOG4105CKK	Glycosyl transferase, family 2
WS105_0841	ENOG4105D3Q	Sugar transferase
WS105_0842	ENOG4105CA1	Removes the N-terminal methionine from nascent proteins (By similarity)
WS105_0845	ENOG4105EY8	ABC transporter
WS105_0847	ENOG4107ZIC	Glycerol-3-phosphate cytidylyltransferase
WS105_0848	ENOG4105C88	aminopeptidase
WS105_0853	ENOG4105CS9	pantothenic acid kinase
WS105_0854	ENOG4105EEM	helicase
WS105_0855	ENOG4105C68	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)
WS105_0856	ENOG4105CEV	competence damage-inducible protein
WS105_0857	ENOG4105BZQ	cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase
WS105_0861	ENOG4105CQX	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity)
WS105_0865	ENOG4105CMG	Carbohydrate kinase
WS105_0866	ENOG4105EQI	Metal Dependent Phosphohydrolase
WS105_0868	ENOG4107VRP	DNA repair exonuclease
WS105_0870	ENOG4105WZB	UPF0342 protein
WS105_0871	ENOG4105BZ4	penicillin-binding protein
WS105_0872	ENOG4105XBY	Regulates arginine biosynthesis genes (By similarity)
WS105_0873	ENOG4105C75	arginyL-tRNA synthetase
WS105_0875	ENOG4107EEN	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity)
WS105_0876	ENOG4108V82	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
WS105_0878	ENOG4105CBD	Diacylglycerol kinase
WS105_0879	ENOG4105CHT	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
WS105_0880	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
WS105_0882	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
WS105_0886	ENOG4105CPC	Aldo Keto reductase
WS105_0887	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
WS105_0888	ENOG4107RY0	Catalyzes the conversion of dihydroorotate to orotate (By similarity)
WS105_0889	ENOG4105N67	Proton-coupled thiamine transporter YuaJ
WS105_0892	ENOG4105CMY	5-enolpyruvylshikimate-3-phosphate synthase
WS105_0893	ENOG4105D10	5-enolpyruvylshikimate-3-phosphate phospholyase
WS105_0894	ENOG4105D49	3-dehydroquinate synthase
WS105_0895	ENOG4108JPM	phospho-2-dehydro-3-deoxyheptonate aldolase
WS105_0896	ENOG4105E2X	shikimate dehydrogenase
WS105_0898	ENOG4105FSR	swimming returnes to normal when residues 206-207 are both mutated to Ala. Overexpression also leads to a reduction in flagellar abundance and a 20-fold increase in c-di- GMP levels in vivo. Required for aminoglycoside-mediated induction of biofilm formation, it also plays a lesser role in biofilm production in response to other classes of translation inhibitors. The c-di-GMP produced by this enzyme up-regulates poly-GlcNAc production as well as the biofilm synthesis protein PgaD, although c-di-GMP is probably not the main inducing principle. Cyclic-di- GMP is a second messenger which controls cell surface-associated traits in bacteria
WS105_0901	ENOG4105CHM	Aminotransferase
WS105_0903	ENOG4105CHM	Aminotransferase
WS105_0905	ENOG4105ETE	Transcriptional regulator (LacI family
WS105_0906	ENOG4105D5I	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity)
WS105_0909	ENOG4107RPQ	ABC transporter
WS105_0911	ENOG4108Z6X	(sortase) family
WS105_0912	ENOG4105FF6	Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity)
WS105_0913	ENOG4105FDU	atp-dependent rna helicase
WS105_0914	ENOG4105EE0	oxidoreductase
WS105_0915	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
WS105_0917	ENOG4108V0P	LemA family
WS105_0926	ENOG4105D5D	udp-galactopyranose mutase
WS105_0927	ENOG4105C83	adenylosuccinate lyase
WS105_0928	ENOG4107UUG	Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity)
WS105_0930	ENOG4105C1M	carbamoyl-phosphate synthetase glutamine chain
WS105_0931	ENOG4108UK1	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity)
WS105_0932	ENOG4105C34	Pseudouridine synthase
WS105_0934	ENOG4105DFD	Na H antiporter
WS105_0935	ENOG4105C85	amino acid
WS105_0937	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
WS105_0938	ENOG4105BZA	Phosphoglycerate kinase
WS105_0939	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
WS105_0943	ENOG4105CGH	5'-nucleotidase
WS105_0950	ENOG4105ZT7	DNA-entry nuclease
WS105_0952	ENOG4105F3R	pts system mannose fructose sorbose family iid
WS105_0953	ENOG4105ETZ	PTS System
WS105_0958	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
WS105_0960	ENOG4105DQR	SNARE associated Golgi
WS105_0961	ENOG4105ZAD	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity)
WS105_0962	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
WS105_0963	ENOG4105C4F	May be involved in recombinational repair of damaged DNA (By similarity)
WS105_0964	ENOG4105XBY	Regulates arginine biosynthesis genes (By similarity)
WS105_0965	ENOG4105DX0	Hemolysin A
WS105_0967	ENOG41067QG	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
WS105_0968	ENOG4105DVS	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
WS105_0969	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
WS105_0970	ENOG4108V7D	UPF0397 protein
WS105_0973	ENOG4105CKA	Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity)
WS105_0974	ENOG4105C22	threonyL-tRNA synthetase
WS105_0979	ENOG4105CDE	UPF0348 protein
WS105_0982	ENOG4108WF2	Metal Dependent Phosphohydrolase
WS105_0983	ENOG4108Z1W	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity)
WS105_0984	ENOG4105CQW	ribosome biogenesis GTPase YqeH
WS105_0985	ENOG4108WJV	had superfamily (subfamily IIIa) phosphatase
WS105_0988	ENOG4105C0X	amino acid
WS105_0989	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
WS105_0990	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
WS105_0991	ENOG4105C5H	ABC transporter
WS105_0992	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
WS105_0993	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
WS105_0994	ENOG4108ZUB	Lysine exporter protein (Lyse ygga)
WS105_0995	ENOG4107YZX	Universal stress protein
WS105_0998	ENOG4105D1H	recombination factor protein RarA
WS105_1001	ENOG4105C8A	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity)
WS105_1003	ENOG4105EVI	UPF0374 protein
WS105_1006	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
WS105_1007	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
WS105_1008	ENOG4105E2Z	phosphate ABC transporter (Permease
WS105_1009	ENOG4105C8U	phosphate abc transporter
WS105_1010	ENOG4105CVA	phosphate
WS105_1014	ENOG4108115	UPF0145 protein
WS105_1015	ENOG4105D4U	had-superfamily hydrolase, subfamily iia
WS105_1016	ENOG4105MMD	transcriptional regulator
WS105_1017	ENOG4107R8B	5'-nucleotidase
WS105_1019	ENOG4105DC7	peptidase M24
WS105_1021	ENOG4107J5P	Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity)
WS105_1022	ENOG4105C4A	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity)
WS105_1023	ENOG4105E4F	Isochorismate synthase
WS105_1025	ENOG4107RES	phosphoglycerol transferase I
WS105_1026	ENOG4107R7I	amino acid
WS105_1028	ENOG4105C2C	drug resistance transporter, Bcr CflA
WS105_1034	ENOG4105CK1	PTS System
WS105_1036	ENOG4105VZJ	PTS System
WS105_1037	ENOG4105VCP	PTS System
WS105_1038	ENOG4105E0A	ABC, transporter
WS105_1045	ENOG4105K46	50S ribosomal protein l27
WS105_1047	ENOG4105CXY	transporter
WS105_1052	ENOG4105C5F	glutamine synthetase
WS105_1053	ENOG4105KV4	Transcriptional regulator
WS105_1057	ENOG4105DKQ	ROK family
WS105_1060	ENOG4105MK2	5-formyltetrahydrofolate cyclo-ligase
WS105_1061	ENOG4107RF6	penicillin-binding protein
WS105_1063	ENOG4108UKH	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
WS105_1065	ENOG4105C6A	phenylalanyl-tRNA synthetase (beta subunit)
WS105_1066	ENOG4105CSS	phenylalanyl-tRNA synthetase (alpha subunit)
WS105_1069	ENOG4108RWN	rrna methyltransferase
WS105_1072	ENOG4105CG1	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity)
WS105_1073	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
WS105_1074	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
WS105_1076	ENOG4107Z0P	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity)
WS105_1078	ENOG4105K4H	Nlp p60 protein
WS105_1080	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
WS105_1081	ENOG4105CIS	alcohol dehydrogenase
WS105_1083	ENOG4107FQX	Alpha-acetolactate decarboxylase
WS105_1088	ENOG41086FC	50S ribosomal protein l32
WS105_1091	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
WS105_1093	ENOG4105CIE	May be required for sporulation (By similarity)
WS105_1094	ENOG4105CHW	UPF0052 protein
WS105_1097	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
WS105_1102	ENOG4108UJD	30S ribosomal protein S9
WS105_1103	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
WS105_1104	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
WS105_1106	ENOG4108JJB	ABC transporter
WS105_1107	ENOG4108JJB	ABC transporter
WS105_1108	ENOG4106HWW	Acyltransferase family
WS105_1111	ENOG4105DSE	periplasmic solute binding protein
WS105_1112	ENOG4105CC5	ABC transporter
WS105_1113	ENOG4105DIK	(ABC) transporter
WS105_1115	ENOG4105E0X	reductase
WS105_1116	ENOG4105KBC	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
WS105_1117	ENOG4108VZM	50s ribosomal protein L10
WS105_1118	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
WS105_1119	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
WS105_1120	ENOG4105E5V	Participates in transcription elongation, termination and antitermination (By similarity)
WS105_1121	ENOG410683Z	Preprotein translocase SecE subunit
WS105_1122	ENOG4107FTN	50S ribosomal protein L33
WS105_1124	ENOG4105C2N	RNA methyltransferase TrmH family group 3
WS105_1125	ENOG4105KEB	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
WS105_1126	ENOG4105C8N	cysteinyl-tRNA synthetase
WS105_1128	ENOG4107RA1	nh(3)-dependent nad( ) synthetase
WS105_1129	ENOG4105DAP	Nicotinate phosphoribosyltransferase
WS105_1130	ENOG4105D01	(LipO)protein
WS105_1131	ENOG4108JEI	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity)
WS105_1132	ENOG4108UMI	ABC transporter, permease
WS105_1134	ENOG4105CTF	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
WS105_1135	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
WS105_1136	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
WS105_1137	ENOG41067V7	50S ribosomal protein L36
WS105_1138	ENOG4105K9U	however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)
WS105_1140	ENOG4105CGG	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity)
WS105_1141	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
WS105_1143	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
WS105_1145	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
WS105_1146	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
WS105_1147	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
WS105_1148	ENOG4105KAR	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity)
WS105_1149	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
WS105_1150	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
WS105_1151	ENOG41082SA	50s ribosomal protein l29
WS105_1153	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
WS105_1154	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
WS105_1156	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
WS105_1157	ENOG41080UE	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
WS105_1158	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
WS105_1159	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
WS105_1160	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
WS105_1165	ENOG41072GX	Peptidase M22 Glycoprotease
WS105_1166	ENOG4105CMR	udp-glucose 4-epimerase
WS105_1168	ENOG4105CU0	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity)
WS105_1170	ENOG4105X0R	protein from nitrogen regulatory protein P-II
WS105_1171	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
WS105_1173	ENOG4105F3K	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity)
WS105_1174	ENOG410816I	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity)
WS105_1175	ENOG4105C6E	dna polymerase iii
WS105_1177	ENOG4107Y49	methyltransferase
WS105_1184	ENOG4107QW4	alcohol dehydrogenase
WS105_1185	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
WS105_1186	ENOG4108IIJ	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
WS105_1186a	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
WS105_1186b	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
WS105_1187	ENOG4105KEX	transcriptional regulator, ctsr
WS105_1188	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
WS105_1189	ENOG4105ZMH	deoxynucleoside kinase
WS105_1192	ENOG4105KNM	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
WS105_1193	ENOG4105C4J	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
WS105_1194	ENOG4105J80	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity)
WS105_1195	ENOG4105CDG	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity)
WS105_1197	ENOG4107ZFM	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity)
WS105_1198	ENOG4105WS6	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
WS105_1199	ENOG4107RFS	it plays a direct role in the translocation of protons across the membrane (By similarity)
WS105_1202	ENOG4105CZ5	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity)
WS105_1203	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
WS105_1204	ENOG4105EK0	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
WS105_1205	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
WS105_1206	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
WS105_1207	ENOG4107104	thymidine kinase
WS105_1208	ENOG4105F1K	Glutamine amidotransferase
WS105_1209	ENOG4105DMS	mur ligase
WS105_1210	ENOG4105DG6	mannose-6-phosphate isomerase
WS105_1216	ENOG4105DU0	nucleoside hydrolase
WS105_1220	ENOG4105BZ1	(ABC) transporter
WS105_1221	ENOG4105BZ1	(ABC) transporter
WS105_1222	ENOG4105C1N	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity)
WS105_1223	ENOG4105DKJ	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
WS105_1224	ENOG4108RG0	uracil-dna glycosylase
WS105_1225	ENOG4105C6Z	Gluconate
WS105_1226	ENOG4105CGK	Exodeoxyribonuclease III
WS105_1227	ENOG4108EKI	Dehydrogenase
WS105_1228	ENOG4105CEU	Arginine dihydrolase
WS105_1229	ENOG4105DBV	ornithine carbamoyltransferase
WS105_1230	ENOG4105D5Q	Arginine ornithine antiporter
WS105_1232	ENOG4105C9K	Endothelin-converting enzyme 1
WS105_1235	ENOG4107QRI	Phosphoketolase
WS105_1236	ENOG4108TZY	GntR Family Transcriptional Regulator
WS105_1237	ENOG4105EST	Metal Dependent Phosphohydrolase
WS105_1243	ENOG4105C5H	ABC transporter
WS105_1245	ENOG4105FDK	ABC transporter
WS105_1247	ENOG4107DA6	Transcriptional regulator
WS105_1248	ENOG410906U	SprT-like
WS105_1252	ENOG4105DUX	Transporter
WS105_1254	ENOG4105BZU	Histidine kinase
WS105_1255	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
WS105_1257	ENOG4105C3G	gtp-binding protein
WS105_1258	ENOG4105VDK	protein, conserved in bacteria
WS105_1259	ENOG4105FA0	parb-like partition protein
WS105_1260	ENOG4107QJE	Chromosome Partitioning Protein
WS105_1262	ENOG4105CEN	a g-specific adenine glycosylase
WS105_1264	ENOG4105US7	Histidine kinase
WS105_1265	ENOG4108STX	response regulator
WS105_1266	ENOG4105CEY	Amp-dependent synthetase and ligase
WS105_1267	ENOG4108IPT	Naphthoate synthase
WS105_1271	ENOG4105VEM	Conserved domain protein
WS105_1272	ENOG4105HDK	L-asparaginase
WS105_1273	ENOG4105CUB	amino acid
WS105_1276	ENOG4105CJH	Alcohol dehydrogenase zinc-binding domain protein
WS105_1278	ENOG4105D8C	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity)
WS105_1286	ENOG4107U9W	Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S- specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX (By similarity)
WS105_1289	ENOG4107URF	beta-phospho-glucomutase
WS105_1290	ENOG4105C71	hydrolase family 65, central catalytic
WS105_1291	ENOG4105C5Y	PTS System
WS105_1292	ENOG4108IIZ	The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane
WS105_1293	ENOG4107414	GntR family transcriptional regulator
WS105_1294	ENOG4105ECB	domain protein
WS105_1295	ENOG41062ES	Transcriptional regulator
WS105_1298	ENOG41067QW	Transcriptional regulator
WS105_1303	ENOG4105C85	amino acid
WS105_1304	ENOG4105C02	permease
WS105_1306	ENOG4105EAB	amino acid AbC transporter
WS105_1307	ENOG4105E5Q	amino acid AbC transporter
WS105_1308	ENOG4105CDA	abc transporter atp-binding protein
WS105_1311	ENOG41066UM	arsR family transcriptional regulator
WS105_1312	ENOG4105C59	p-type ATPase
WS105_1313	ENOG4108IND	Tetr family transcriptional regulator
WS105_1314	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
WS105_1315	ENOG4105BZ4	penicillin-binding protein
WS105_1316	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
WS105_1318	ENOG4105C7K	acetolactate synthase
WS105_1320	ENOG4105EMU	Dehydrogenase
WS105_1321	ENOG4105I9P	Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity)
WS105_1322	ENOG4105CV8	reductase
WS105_1323	ENOG4105KVH	Transcriptional regulator
WS105_1324	ENOG4105K85	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity)
WS105_1329	ENOG4108UMW	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
WS105_1331	ENOG4108UXA	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity)
WS105_1332	ENOG4105C85	amino acid
WS105_1333	ENOG4107ZYR	domain protein
WS105_1334	ENOG4105C3F	Signal peptidase i
WS105_1335	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins