locus-tag	class	description
WS74_0001	ENOG4105VG0	50S ribosomal protein l34
WS74_0002	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
WS74_0003	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
WS74_0004	ENOG410848D	S4 domain protein YaaA
WS74_0005	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
WS74_0006	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
WS74_0007	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
WS74_0012	ENOG4106KNT	transcriptional regulator
WS74_0017	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
WS74_0018	ENOG4105C2W	permease
WS74_0019	ENOG4108UPS	Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity)
WS74_0020	ENOG4105C7Q	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity)
WS74_0021	ENOG4105C7N	Xanthine uracil vitamin C permease
WS74_0027	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
WS74_0029	ENOG4108R3E	Dna-3-methyladenine glycosylase i
WS74_0031	ENOG4105C8T	Leucyl-tRNA synthetase
WS74_0035	ENOG4107R7I	amino acid
WS74_0037	ENOG4105C5N	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
WS74_0038	ENOG4107R2I	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation
WS74_0042	ENOG4108HMR	Key enzyme in the regulation of glycerol uptake and metabolism (By similarity)
WS74_0043	ENOG4105DFT	pur operon repressor
WS74_0044	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
WS74_0045	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
WS74_0046	ENOG4108WQ8	UPF0637 protein
WS74_0047	ENOG4108ZDX	Binds together with S18 to 16S ribosomal RNA (By similarity)
WS74_0048	ENOG4108UUM	single-stranded DNA-binding protein
WS74_0049	ENOG4105VH8	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity)
WS74_0050	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
WS74_0051	ENOG4105BZU	Histidine kinase
WS74_0054	ENOG4105Q2H	domain protein
WS74_0055	ENOG4105C0H	protease
WS74_0057	ENOG4105DCI	Phosphohydrolase
WS74_0058	ENOG410667J	hydrolase
WS74_0059	ENOG4108Z1Y	Participates in both the initiation and recycling phases of transcription. In the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling (By similarity)
WS74_0060	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
WS74_0061	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
WS74_0062	ENOG4105C1J	atp-dependent rna helicase
WS74_0063	ENOG41082V8	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity)
WS74_0064	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
WS74_0065	ENOG4108YZM	Toxic component of a toxin-antitoxin (TA) module (By similarity)
WS74_0066	ENOG4105EEM	helicase
WS74_0068	ENOG4105C9X	ppx gppa phosphatase
WS74_0073	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
WS74_0077	ENOG4105CT1	(ABC) transporter
WS74_0078	ENOG4105EAD	ABC transporter
WS74_0079	ENOG4105DRP	amino acid AbC transporter
WS74_0082	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
WS74_0083	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
WS74_0085	ENOG4108JQ7	(ABC) transporter
WS74_0087	ENOG4105K9Q	Binds to the 23S rRNA (By similarity)
WS74_0088	ENOG4105CDU	Replicative dna helicase
WS74_0089	ENOG410605W	Major Facilitator
WS74_0092	ENOG4105CTR	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity)
WS74_0094	ENOG4105CAY	ferredoxin--nadp reductase
WS74_0095	ENOG4105DKJ	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
WS74_0096	ENOG4105EY8	ABC transporter
WS74_0099	ENOG4107T5V	SNARE associated Golgi
WS74_0103	ENOG4107EES	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity)
WS74_0104	ENOG4105DFF	Rod shape-determining protein mreb
WS74_0106	ENOG4105CNI	cell division protein FtsW
WS74_0107	ENOG4105II7	pyrroline-5-carboxylate reductase
WS74_0108	ENOG4108HCJ	Hydrolase
WS74_0109	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
WS74_0110	ENOG4105CE4	GlcNAc 6-P deacetylase
WS74_0111	ENOG4105FDP	GntR family transcriptional regulator
WS74_0112	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
WS74_0114	ENOG4105C7N	Xanthine uracil vitamin C permease
WS74_0116	ENOG4108UGV	hypoxanthine phosphoribosyltransferase
WS74_0120	ENOG4108HCJ	Hydrolase
WS74_0121	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
WS74_0122	ENOG4105KNE	Phosphatidate cytidylyltransferase
WS74_0123	ENOG4105DZP	Membrane-associated zinc metalloprotease
WS74_0124	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
WS74_0125	ENOG4105DE5	Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity)
WS74_0126	ENOG4105C2N	RNA methyltransferase TrmH family group 3
WS74_0138	ENOG4105E4Y	Endoribonuclease that initiates mRNA decay (By similarity)
WS74_0141	ENOG4107SJ1	Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity)
WS74_0160	ENOG4105FSR	swimming returnes to normal when residues 206-207 are both mutated to Ala. Overexpression also leads to a reduction in flagellar abundance and a 20-fold increase in c-di- GMP levels in vivo. Required for aminoglycoside-mediated induction of biofilm formation, it also plays a lesser role in biofilm production in response to other classes of translation inhibitors. The c-di-GMP produced by this enzyme up-regulates poly-GlcNAc production as well as the biofilm synthesis protein PgaD, although c-di-GMP is probably not the main inducing principle. Cyclic-di- GMP is a second messenger which controls cell surface-associated traits in bacteria
WS74_0162	ENOG4105BZU	Histidine kinase
WS74_0167	ENOG4105MRB	Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity)
WS74_0168	ENOG4105EV1	Ribose uptake protein RbsU
WS74_0169	ENOG4105KPY	Small multidrug resistance protein
WS74_0170	ENOG4105D64	Mechanosensitive ion channel
WS74_0171	ENOG4105CSC	Glucose uptake protein
WS74_0172	ENOG4107QYV	phosphohexose isomerase
WS74_0173	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
WS74_0174	ENOG4108ZSR	alkaline shock protein
WS74_0175	ENOG4105M7K	Involved in the transcription termination process (By similarity)
WS74_0176	ENOG4108UUX	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity)
WS74_0177	ENOG4105VJV	50s ribosomal protein L35
WS74_0178	ENOG4108YZX	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity)
WS74_0179	ENOG4108UKE	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity)
WS74_0180	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
WS74_0181	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
WS74_0182	ENOG4105D9R	oxidoreductase
WS74_0183	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
WS74_0184	ENOG4105EUS	Binding-protein-dependent transport systems, inner membrane component
WS74_0185	ENOG4105D38	putrescine abc transporter
WS74_0186	ENOG4107RUE	extracellular solute-binding protein family 1
WS74_0187	ENOG4108R5K	PPIases accelerate the folding of proteins (By similarity)
WS74_0188	ENOG41086DT	Membrane protein of unknown function
WS74_0189	ENOG4105D1C	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity)
WS74_0190	ENOG4105CSF	NADPH-dependent glycerol-3-phosphate dehydrogenase
WS74_0192	ENOG4105C3M	thioredoxin reductase
WS74_0194	ENOG4105KRI	phosphocarrier protein (HPr
WS74_0195	ENOG4105BZ3	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity)
WS74_0196	ENOG4105CP7	Triose-phosphate isomerase
WS74_0197	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
WS74_0199	ENOG4105C40	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity)
WS74_0200	ENOG4108UH4	Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity)
WS74_0201	ENOG4105E5Q	amino acid AbC transporter
WS74_0202	ENOG4105CDA	abc transporter atp-binding protein
WS74_0203	ENOG4105D5S	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity)
WS74_0204	ENOG4108IJ2	phosphate acetyltransferase
WS74_0205	ENOG4105K8N	protein family UPF0079, ATPase
WS74_0207	ENOG4105DE5	Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity)
WS74_0208	ENOG4105D4A	Cell wall formation (By similarity)
WS74_0211	ENOG4107QJF	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity)
WS74_0213	ENOG4105CXT	aspartate transcarbamylase
WS74_0214	ENOG4105CD3	dihydroorotase
WS74_0215	ENOG4105C1M	carbamoyl-phosphate synthetase glutamine chain
WS74_0216	ENOG4105CU6	carbamoyl-phosphate synthetase ammonia chain
WS74_0217	ENOG4106EG9	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity)
WS74_0218	ENOG41065E1	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
WS74_0219	ENOG4105BZF	Glycosyl transferase (Group 1
WS74_0220	ENOG4105W2C	Glycosyl transferase
WS74_0222	ENOG4105E0M	Sulfatase
WS74_0223	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
WS74_0224	ENOG4107SUZ	Sodium/hydrogen exchanger family
WS74_0225	ENOG4105F8V	Hydrolase, tatD family
WS74_0226	ENOG4105HVR	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity)
WS74_0228	ENOG4105C37	(CBS) domain
WS74_0229	ENOG4105W42	Veg protein
WS74_0230	ENOG4108UK2	deaminase
WS74_0231	ENOG4105C0V	Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity)
WS74_0232	ENOG4108KGH	TRANSCRIPTIONal
WS74_0233	ENOG41067S9	phage shock protein C, PspC
WS74_0234	ENOG4105DWR	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity)
WS74_0235	ENOG4107S2Z	UPF0761 membrane protein
WS74_0238	ENOG4108ZPD	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity)
WS74_0239	ENOG4108JA2	transcriptioN-repair coupling factor
WS74_0241	ENOG41082I2	s4 domain protein
WS74_0244	ENOG4108UGV	hypoxanthine phosphoribosyltransferase
WS74_0247	ENOG4105CRK	lysyL-tRNA synthetase
WS74_0252	ENOG4105C4M	(Ubiquinol oxidase) subunit I
WS74_0253	ENOG4105CFY	cytochrome d ubiquinol oxidase, subunit ii
WS74_0254	ENOG4108JJ9	ABC, transporter
WS74_0255	ENOG4108JJ8	(ABC) transporter
WS74_0256	ENOG4108ZW7	flagellar rod assembly protein muramidase flgj
WS74_0262	ENOG4105VEQ	Cold shock protein
WS74_0263	ENOG4108YZ4	nudix hydrolase
WS74_0265	ENOG4105DUF	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity)
WS74_0269	ENOG4105WAZ	(Glutaredoxin-like protein) NrdH
WS74_0270	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
WS74_0271	ENOG4105E05	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
WS74_0273	ENOG4105C7J	ABC transporter, permease
WS74_0274	ENOG4105E2Y	ABC, transporter
WS74_0278	ENOG4105W5Q	DNA repair protein (RadC
WS74_0279	ENOG4105DFF	Rod shape-determining protein mreb
WS74_0280	ENOG4105N3I	Involved in formation and maintenance of cell shape (By similarity)
WS74_0283	ENOG4105E5Q	amino acid AbC transporter
WS74_0285	ENOG4105E89	ABC transporter
WS74_0286	ENOG4105CKU	formyltetrahydrofolate synthetase
WS74_0291	ENOG4108IQI	permease
WS74_0292	ENOG4105CA9	Pyruvate kinase
WS74_0293	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
WS74_0294	ENOG4107TVK	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity)
WS74_0295	ENOG4108V6E	Cell division protein mraZ
WS74_0298	ENOG4105CJN	penicillin-binding protein
WS74_0300	ENOG4105DMZ	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity)
WS74_0301	ENOG4105DVQ	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity)
WS74_0302	ENOG4108W8M	Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity)
WS74_0303	ENOG4105CIT	This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity)
WS74_0304	ENOG4105CDK	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity)
WS74_0305	ENOG4105VR5	Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity)
WS74_0306	ENOG41067XK	integral membrane protein
WS74_0307	ENOG4105DBK	s4 domain protein
WS74_0309	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
WS74_0312	ENOG4105C7H	Helicase, RecD TraA family
WS74_0313	ENOG4105CDY	transcriptional regulatory protein
WS74_0316	ENOG4106855	Competence protein
WS74_0319	ENOG4105C25	Primosomal protein n'
WS74_0320	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
WS74_0321	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
WS74_0323	ENOG4105D9P	serine threonine protein kinase
WS74_0324	ENOG4105E06	May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity)
WS74_0325	ENOG4105DJV	ribulose-phosphate 3-epimerase
WS74_0327	ENOG4105VB9	50S ribosomal protein l28
WS74_0329	ENOG4105DP4	dak2 domain fusion protein ylov
WS74_0330	ENOG4105CB5	ATP-dependent DNA helicase recG
WS74_0331	ENOG4105C6B	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity)
WS74_0332	ENOG4105VNB	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
WS74_0333	ENOG4108ZBM	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity)
WS74_0334	ENOG4105CDB	Required for chromosome condensation and partitioning (By similarity)
WS74_0335	ENOG4105CCP	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
WS74_0337	ENOG4105CB9	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
WS74_0338	ENOG4105K5M	30s ribosomal protein S16
WS74_0339	ENOG4107Z8R	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity)
WS74_0340	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
WS74_0341	ENOG4108YY1	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity)
WS74_0342	ENOG4107AYK	membrAne
WS74_0343	ENOG41069HH	4-oxalocrotonate tautomerase
WS74_0345	ENOG4105M6F	mutator MutT protein
WS74_0346	ENOG4105ZMH	deoxynucleoside kinase
WS74_0348	ENOG410667J	hydrolase
WS74_0352	ENOG4108VY7	phosphate-starvation-inducible protein PsiE
WS74_0353	ENOG4108SQ7	Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis
WS74_0357	ENOG4105DC7	peptidase M24
WS74_0358	ENOG4105ETE	Transcriptional regulator (LacI family
WS74_0363	ENOG4105CJS	Phosphopantothenoylcysteine decarboxylase
WS74_0364	ENOG4105F99	Hydroxymethylglutaryl-CoA synthase
WS74_0366	ENOG4105C5C	n-acetylmuramoyl-l-alanine amidase
WS74_0367	ENOG4105CUT	histidyl-tRNA synthetase
WS74_0368	ENOG4105C9M	aspartyl-trna synthetase
WS74_0369	ENOG4107AYK	membrAne
WS74_0370	ENOG4105VCC	30S ribosomal protein S21
WS74_0371	ENOG4105KTH	gatB Yqey
WS74_0372	ENOG4105KGE	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity)
WS74_0373	ENOG4107YR5	Diacylglycerol kinase
WS74_0374	ENOG4105CWT	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity)
WS74_0375	ENOG4108SAY	Involved in DNA repair and RecF pathway recombination (By similarity)
WS74_0376	ENOG4108HMW	glycyl-tRNA synthetase, alpha subunit
WS74_0377	ENOG4105C38	Glycyl-tRNA synthetase beta subunit
WS74_0379	ENOG4105D2N	Aldolase
WS74_0380	ENOG4105D8C	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity)
WS74_0381	ENOG4105DAA	L-lactate
WS74_0383	ENOG4105DU1	integral membrane protein, terc
WS74_0384	ENOG4105HHQ	6-phosphogluconolactonase (EC 3.1.1.31)
WS74_0385	ENOG4108UIQ	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity)
WS74_0386	ENOG4105CNU	cell division protein FtsK
WS74_0387	ENOG4108IUX	(ABC) transporter
WS74_0388	ENOG4105RHA	ABC transporter, permease
WS74_0389	ENOG4107T6V	glycerophosphoryl diester phosphodiesterase
WS74_0391	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
WS74_0392	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
WS74_0394	ENOG4108ZK7	protein family UPF0029, Impact, N-terminal protein
WS74_0395	ENOG4105C6X	Major Facilitator
WS74_0396	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
WS74_0397	ENOG4105KA4	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity)
WS74_0399	ENOG4105VIE	preprotein translocase, subunit YajC
WS74_0400	ENOG4105CQ3	Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity)
WS74_0401	ENOG4105SFS	phosphoesterase RecJ domain protein
WS74_0402	ENOG4105C1J	atp-dependent rna helicase
WS74_0403	ENOG4108UW5	maltose o-acetyltransferase
WS74_0404	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
WS74_0406	ENOG4108Z08	Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity)
WS74_0407	ENOG4105VPH	UPF0473 protein
WS74_0408	ENOG4105VPH	UPF0473 protein
WS74_0409	ENOG41083P1	competence protein ComEA helix-hairpin-helix repeat protein
WS74_0410	ENOG4105EGY	DNA internalization-related competence protein ComEC Rec2
WS74_0411	ENOG4105TQK	DNA polymerase iii, delta' subunit
WS74_0412	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
WS74_0413	ENOG4105KQV	Binds directly to 16S ribosomal RNA (By similarity)
WS74_0417	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
WS74_0418	ENOG4105DEA	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation
WS74_0419	ENOG4105CHN	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
WS74_0420	ENOG4105WHM	Necessary for normal cell division and for the maintenance of normal septation (By similarity)
WS74_0423	ENOG4105C98	muts2 protein
WS74_0425	ENOG4105K63	Thioredoxin
WS74_0426	ENOG4105F03	Provides the (R)-glutamate required for cell wall biosynthesis (By similarity)
WS74_0427	ENOG4108V82	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
WS74_0430	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
WS74_0431	ENOG4105EMS	pseudouridine synthase
WS74_0432	ENOG4105CJW	magnesium transporter
WS74_0433	ENOG4105K7D	Required for maturation of 30S ribosomal subunits (By similarity)
WS74_0434	ENOG4105CHV	Transcription elongation factor NusA
WS74_0435	ENOG4105VZN	Nucleic-acid-binding protein implicated in transcription termination
WS74_0437	ENOG4107EEM	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
WS74_0438	ENOG4105KG7	Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity)
WS74_0439	ENOG4108MK9	spermidine N(1)-acetyltransferase
WS74_0440	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
WS74_0442	ENOG4105DTN	riboflavin biosynthesis protein ribF
WS74_0443	ENOG4105F23	Fibronectin-binding protein
WS74_0444	ENOG4106N3A	copper homeostasis protein cutc
WS74_0445	ENOG4105EPR	degv family
WS74_0446	ENOG4108RCR	degv family
WS74_0447	ENOG4105CXG	d-lactate dehydrogenase
WS74_0448	ENOG4106E6V	UPF0346 protein
WS74_0449	ENOG4105C9W	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity)
WS74_0450	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
WS74_0451	ENOG4106432	Mediates binding to human platelets, possibly through a receptor-ligand interaction. Probably associated with virulence in endovascular infection (By similarity)
WS74_0453	ENOG4105C79	DNA protecting protein DprA
WS74_0454	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
WS74_0455	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
WS74_0458	ENOG4105F27	Major Facilitator
WS74_0459	ENOG4105K7Z	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity)
WS74_0460	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
WS74_0461	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
WS74_0465	ENOG4105E2M	Manganese-dependent inorganic pyrophosphatase
WS74_0467	ENOG4108IJ7	Glycine betaine
WS74_0475	ENOG4105KWG	Pfam:DUF1696
WS74_0479	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
WS74_0480	ENOG4105WBI	UPF0223 protein
WS74_0481	ENOG4105ECY	inositol monophosphatase
WS74_0482	ENOG4105CI3	gtp-binding protein typa
WS74_0483	ENOG4105CNI	cell division protein FtsW
WS74_0484	ENOG4105WUC	UPF0298 protein
WS74_0485	ENOG4106H78	methyltransferase
WS74_0486	ENOG4108ZEF	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)
WS74_0487	ENOG41063PX	domain protein
WS74_0488	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
WS74_0489	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
WS74_0491	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
WS74_0493	ENOG4105DPZ	Two component transcriptional regulator (Winged helix family
WS74_0494	ENOG4105BZU	Histidine kinase
WS74_0496	ENOG4108VDD	TRNA binding domain protein
WS74_0498	ENOG4105DFU	Cell wall formation (By similarity)
WS74_0499	ENOG4105HFZ	Membrane
WS74_0503	ENOG4105ERD	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity)
WS74_0504	ENOG4108ZQD	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity)
WS74_0509	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
WS74_0510	ENOG4105GR3	Histidine kinase
WS74_0512	ENOG4107SC7	Inner membrane transporter yjeM
WS74_0513	ENOG4108WCX	response regulator
WS74_0516	ENOG4105C28	cystathionine
WS74_0521	ENOG4107PP3	Acetylornithine deacetylase
WS74_0523	ENOG4105C5H	ABC transporter
WS74_0536	ENOG4105CQ3	Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity)
WS74_0539	ENOG4105DZW	Dipeptidase
WS74_0540	ENOG4108TYN	CAAX amino terminal protease family protein
WS74_0556	ENOG4105K64	Glycosyl transferase, family 2
WS74_0557	ENOG4108UT2	hemolysin iii
WS74_0560	ENOG4107QTG	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity)
WS74_0561	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
WS74_0562	ENOG4108YXN	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity)
WS74_0564	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
WS74_0565	ENOG4105CHR	reductase
WS74_0566	ENOG4108JA1	polyketide synthase
WS74_0569	ENOG410854A	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
WS74_0570	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
WS74_0572	ENOG4108YXN	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity)
WS74_0573	ENOG4105EXC	Acyl-transferase
WS74_0576	ENOG4107QMW	pyridine nucleotide-disulfide oxidoreductase
WS74_0580	ENOG4108UV6	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity)
WS74_0581	ENOG4105DWF	phosphomethylpyrimidine kinase
WS74_0582	ENOG4105C4U	4-methyl-5-beta-hydroxyethylthiazole kinase
WS74_0583	ENOG4105CPN	adenine deaminase
WS74_0585	ENOG4107VXM	glycerophosphoryl diester phosphodiesterase
WS74_0588	ENOG4108HCJ	Hydrolase
WS74_0589	ENOG4106TD9	Diguanylate cyclase
WS74_0592	ENOG4105CZ1	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity)
WS74_0595	ENOG4105K59	histidine triad (HIT) protein
WS74_0597	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
WS74_0601	ENOG4105C4R	Atp-dependent dna helicase
WS74_0605	ENOG4108CHM	Preferentially cleaves peptide bonds on the carboxyl- terminal side of aspartate and glutamate. Along with other extracellular proteases it is involved in colonization and infection of human tissues. Required for proteolytic maturation of thiol protease SspB and inactivation of SspC, an inhibitor of SspB. It is the most important protease for degradation of fibronectin-binding protein (FnBP) and surface protein A, which are involved in adherence to host cells. May also protect bacteria against host defense mechanism by cleaving the immunoglobulin classes IgG, IgA and IgM. May be involved in the stability of secreted lipases
WS74_0606	ENOG4105C4H	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity)
WS74_0607	ENOG4105XWG	Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation (By similarity)
WS74_0608	ENOG4108UKS	UPF0398 protein
WS74_0609	ENOG4108UI2	Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity)
WS74_0615	ENOG4105C5S	asparaginyl-tRNA synthetase
WS74_0617	ENOG4105DVT	helicase
WS74_0618	ENOG4107BMA	Transglycosylase associated protein
WS74_0634	ENOG4106UJV	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity)
WS74_0636	ENOG4107XQC	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins (By similarity)
WS74_0638	ENOG4108UGX	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity)
WS74_0640	ENOG4107R7I	amino acid
WS74_0642	ENOG4105HMI	Membrane
WS74_0644	ENOG4105CND	Glycosyl transferase, family 2
WS74_0646	ENOG4105CHU	acetyl-coa acetyltransferase
WS74_0648	ENOG4105G5W	regulator Fur family
WS74_0650	ENOG4105C4B	ABC transporter, permease
WS74_0651	ENOG41083J0	(ABC) transporter
WS74_0652	ENOG41067V2	Esterase lipase
WS74_0653	ENOG4107RHR	regulatoR
WS74_0655	ENOG4105C19	ABC transporter
WS74_0657	ENOG4107QN2	dihydrolipoyl dehydrogenase
WS74_0659	ENOG4105CPP	Dehydrogenase, E1 component
WS74_0661	ENOG4105DF9	Lipoate-protein, ligase
WS74_0662	ENOG4105CG3	alpha amylase, catalytic region
WS74_0665	ENOG4105KNA	-acetyltransferase
WS74_0669	ENOG4105TPC	MazG nucleotide pyrophosphohydrolase domain
WS74_0670	ENOG4108URH	decarboxylase
WS74_0675	ENOG4105FKQ	transcriptional regulator
WS74_0677	ENOG4105CKU	formyltetrahydrofolate synthetase
WS74_0678	ENOG4105C12	Phosphoribosylglycinamide synthetase
WS74_0679	ENOG4105DC1	bifunctional purine biosynthesis protein purh
WS74_0680	ENOG4108V3E	phosphoribosylglycinamide formyltransferase
WS74_0681	ENOG4105CXB	phosphoribosylaminoimidazole synthetase
WS74_0683	ENOG4108JIU	phosphoribosylformylglycinamidine synthase ii
WS74_0684	ENOG4105D21	Phosphoribosylformylglycinamidine synthase I
WS74_0686	ENOG4105C8V	SAICAR synthetase
WS74_0687	ENOG4105CY8	phosphoribosylaminoimidazole carboxylase atpase subunit
WS74_0688	ENOG4108UM6	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity)
WS74_0689	ENOG4108M4D	D-alanyl-lipoteichoic acid biosynthesis protein DltD
WS74_0690	ENOG4105X96	Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Activated D-alanyl-Dcp donates its D-alanyl substituent to membrane-associated LTA (By similarity)
WS74_0691	ENOG4105CK0	Membrane bOund o-acyl transferase mboat family protein
WS74_0692	ENOG4108IQD	Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity)
WS74_0695	ENOG4106KNP	GTP-binding protein LepA C-terminus
WS74_0699	ENOG4108QHG	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity)
WS74_0700	ENOG4105KPE	licD family
WS74_0703	ENOG4105DC8	reductase
WS74_0705	ENOG41082QR	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
WS74_0709	ENOG4105C6H	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity)
WS74_0710	ENOG4105D42	Cleaves the N-terminal amino acid of tripeptides (By similarity)
WS74_0711	ENOG4105EGD	dinuclear metal center protein, YbgI family
WS74_0713	ENOG41068YB	TPR repeat-containing protein
WS74_0719	ENOG4105DJ2	Major Facilitator Superfamily
WS74_0720	ENOG4105PUK	Membrane
WS74_0721	ENOG4105DWF	phosphomethylpyrimidine kinase
WS74_0723	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
WS74_0724	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
WS74_0725	ENOG4105CAT	Cytidine monophosphate kinase
WS74_0727	ENOG4105C9U	ATP-dependent DNA helicase RecQ
WS74_0729	ENOG4108SAX	Membrane
WS74_0730	ENOG4105FE9	pseudouridine synthase
WS74_0731	ENOG4105K8I	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity)
WS74_0732	ENOG4108KVX	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity)
WS74_0735	ENOG4105QNR	S1 RNA binding domain protein
WS74_0737	ENOG4105D8C	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity)
WS74_0738	ENOG4105CP7	Triose-phosphate isomerase
WS74_0739	ENOG4105C6V	Glycerol-3-phosphate dehydrogenase
WS74_0740	ENOG4108HMR	Key enzyme in the regulation of glycerol uptake and metabolism (By similarity)
WS74_0742	ENOG4107RWR	Sodium hydrogen exchanger
WS74_0744	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
WS74_0745	ENOG4105C0B	DNA polymerase III (alpha subunit)
WS74_0748	ENOG4105C5H	ABC transporter
WS74_0749	ENOG4105D4J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
WS74_0752	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
WS74_0755	ENOG4108KGH	TRANSCRIPTIONal
WS74_0757	ENOG4108VCV	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity)
WS74_0758	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
WS74_0759	ENOG4105CU7	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity)
WS74_0762	ENOG4105VC4	domain protein
WS74_0763	ENOG41060K3	Methyltransferase
WS74_0764	ENOG4105F6E	Acyl-transferase
WS74_0765	ENOG4105VXM	UPF0154 protein
WS74_0766	ENOG4105VPS	UPF0291 protein
WS74_0767	ENOG4109003	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity)
WS74_0768	ENOG4105C2R	Single-stranded-DNA-specific exonuclease (RecJ)
WS74_0772	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
WS74_0773	ENOG4105CFG	Acts as a chaperone (By similarity)
WS74_0774	ENOG4105K90	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
WS74_0775	ENOG4105CI8	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity)
WS74_0778	ENOG4105CKK	Glycosyl transferase, family 2
WS74_0780	ENOG4105D3Q	Sugar transferase
WS74_0781	ENOG4105CA1	Removes the N-terminal methionine from nascent proteins (By similarity)
WS74_0784	ENOG4105EY8	ABC transporter
WS74_0786	ENOG4107ZIC	Glycerol-3-phosphate cytidylyltransferase
WS74_0787	ENOG4105C88	aminopeptidase
WS74_0792	ENOG4105CS9	pantothenic acid kinase
WS74_0793	ENOG4105EEM	helicase
WS74_0794	ENOG4105C68	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)
WS74_0795	ENOG4105CEV	competence damage-inducible protein
WS74_0796	ENOG4105BZQ	cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase
WS74_0800	ENOG4105CQX	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity)
WS74_0821	ENOG41060R1	head morphogenesis protein, SPP1 gp7
WS74_0823	ENOG4105IG6	Phage terminase, large subunit
WS74_0853	ENOG4108IMY	Transcriptional regulator
WS74_0856	ENOG4106050	phage regulatory protein, rha family
WS74_0862	ENOG4108IMY	Transcriptional regulator
WS74_0866	ENOG4108IYS	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
WS74_0867	ENOG4105CMG	Carbohydrate kinase
WS74_0868	ENOG4105EQI	Metal Dependent Phosphohydrolase
WS74_0870	ENOG4107VRP	DNA repair exonuclease
WS74_0872	ENOG4105WZB	UPF0342 protein
WS74_0873	ENOG4105BZ4	penicillin-binding protein
WS74_0874	ENOG4105XBY	Regulates arginine biosynthesis genes (By similarity)
WS74_0875	ENOG4105C75	arginyL-tRNA synthetase
WS74_0877	ENOG4107EEN	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity)
WS74_0878	ENOG4108V82	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
WS74_0880	ENOG4105CBD	Diacylglycerol kinase
WS74_0881	ENOG4105CHT	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
WS74_0882	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
WS74_0884	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
WS74_0888	ENOG4105CPC	Aldo Keto reductase
WS74_0889	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
WS74_0890	ENOG4107RY0	Catalyzes the conversion of dihydroorotate to orotate (By similarity)
WS74_0891	ENOG4105N67	Proton-coupled thiamine transporter YuaJ
WS74_0894	ENOG4105CMY	5-enolpyruvylshikimate-3-phosphate synthase
WS74_0895	ENOG4105D10	5-enolpyruvylshikimate-3-phosphate phospholyase
WS74_0896	ENOG4105D49	3-dehydroquinate synthase
WS74_0897	ENOG4108JPM	phospho-2-dehydro-3-deoxyheptonate aldolase
WS74_0898	ENOG4105E2X	shikimate dehydrogenase
WS74_0900	ENOG4105FSR	swimming returnes to normal when residues 206-207 are both mutated to Ala. Overexpression also leads to a reduction in flagellar abundance and a 20-fold increase in c-di- GMP levels in vivo. Required for aminoglycoside-mediated induction of biofilm formation, it also plays a lesser role in biofilm production in response to other classes of translation inhibitors. The c-di-GMP produced by this enzyme up-regulates poly-GlcNAc production as well as the biofilm synthesis protein PgaD, although c-di-GMP is probably not the main inducing principle. Cyclic-di- GMP is a second messenger which controls cell surface-associated traits in bacteria
WS74_0903	ENOG4105CHM	Aminotransferase
WS74_0905	ENOG4105CHM	Aminotransferase
WS74_0907	ENOG4105ETE	Transcriptional regulator (LacI family
WS74_0908	ENOG4105D5I	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity)
WS74_0912	ENOG4107RPQ	ABC transporter
WS74_0914	ENOG4108Z6X	(sortase) family
WS74_0915	ENOG4105FF6	Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity)
WS74_0916	ENOG4105FDU	atp-dependent rna helicase
WS74_0917	ENOG4105EE0	oxidoreductase
WS74_0918	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
WS74_0920	ENOG4108V0P	LemA family
WS74_0929	ENOG4105D5D	udp-galactopyranose mutase
WS74_0930	ENOG4105C83	adenylosuccinate lyase
WS74_0931	ENOG4107UUG	Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity)
WS74_0933	ENOG4105C1M	carbamoyl-phosphate synthetase glutamine chain
WS74_0934	ENOG4108UK1	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity)
WS74_0935	ENOG4105C34	Pseudouridine synthase
WS74_0937	ENOG4105DFD	Na H antiporter
WS74_0938	ENOG4105C85	amino acid
WS74_0940	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
WS74_0941	ENOG4105BZA	Phosphoglycerate kinase
WS74_0942	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
WS74_0946	ENOG4105CGH	5'-nucleotidase
WS74_0953	ENOG4105ZT7	DNA-entry nuclease
WS74_0955	ENOG4105F3R	pts system mannose fructose sorbose family iid
WS74_0956	ENOG4105ETZ	PTS System
WS74_0961	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
WS74_0963	ENOG4105DQR	SNARE associated Golgi
WS74_0964	ENOG4105ZAD	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity)
WS74_0965	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
WS74_0966	ENOG4105C4F	May be involved in recombinational repair of damaged DNA (By similarity)
WS74_0967	ENOG4105XBY	Regulates arginine biosynthesis genes (By similarity)
WS74_0968	ENOG4105DX0	Hemolysin A
WS74_0970	ENOG41067QG	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
WS74_0971	ENOG4105DVS	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
WS74_0972	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
WS74_0973	ENOG4108V7D	UPF0397 protein
WS74_0976	ENOG4105CKA	Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity)
WS74_0977	ENOG4105C22	threonyL-tRNA synthetase
WS74_0982	ENOG4105CDE	UPF0348 protein
WS74_0985	ENOG4108WF2	Metal Dependent Phosphohydrolase
WS74_0986	ENOG4108Z1W	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity)
WS74_0988	ENOG4105CQW	ribosome biogenesis GTPase YqeH
WS74_0989	ENOG4108WJV	had superfamily (subfamily IIIa) phosphatase
WS74_0992	ENOG4105C0X	amino acid
WS74_0993	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
WS74_0994	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
WS74_0995	ENOG4105C5H	ABC transporter
WS74_0996	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
WS74_0997	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
WS74_0998	ENOG4108ZUB	Lysine exporter protein (Lyse ygga)
WS74_0999	ENOG4107YZX	Universal stress protein
WS74_1002	ENOG4105D1H	recombination factor protein RarA
WS74_1005	ENOG4105C8A	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity)
WS74_1007	ENOG4105EVI	UPF0374 protein
WS74_1010	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
WS74_1011	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
WS74_1012	ENOG4105E2Z	phosphate ABC transporter (Permease
WS74_1013	ENOG4105C8U	phosphate abc transporter
WS74_1014	ENOG4105CVA	phosphate
WS74_1018	ENOG4108115	UPF0145 protein
WS74_1019	ENOG4105D4U	had-superfamily hydrolase, subfamily iia
WS74_1020	ENOG4105MMD	transcriptional regulator
WS74_1021	ENOG4107R8B	5'-nucleotidase
WS74_1023	ENOG4105DC7	peptidase M24
WS74_1025	ENOG4107J5P	Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity)
WS74_1026	ENOG4105C4A	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity)
WS74_1027	ENOG4105E4F	Isochorismate synthase
WS74_1029	ENOG4107RES	phosphoglycerol transferase I
WS74_1030	ENOG4107R7I	amino acid
WS74_1032	ENOG4105C2C	drug resistance transporter, Bcr CflA
WS74_1038	ENOG4105CK1	PTS System
WS74_1040	ENOG4105VZJ	PTS System
WS74_1041	ENOG4105VCP	PTS System
WS74_1042	ENOG4105E0A	ABC, transporter
WS74_1049	ENOG4105K46	50S ribosomal protein l27
WS74_1051	ENOG4105CXY	transporter
WS74_1056	ENOG4105C5F	glutamine synthetase
WS74_1057	ENOG4105KV4	Transcriptional regulator
WS74_1061	ENOG4105DKQ	ROK family
WS74_1064	ENOG4105MK2	5-formyltetrahydrofolate cyclo-ligase
WS74_1065	ENOG4107RF6	penicillin-binding protein
WS74_1067	ENOG4108UKH	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
WS74_1069	ENOG4105C6A	phenylalanyl-tRNA synthetase (beta subunit)
WS74_1070	ENOG4105CSS	phenylalanyl-tRNA synthetase (alpha subunit)
WS74_1073	ENOG4108RWN	rrna methyltransferase
WS74_1076	ENOG4105CG1	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity)
WS74_1077	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
WS74_1078	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
WS74_1080	ENOG4107Z0P	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity)
WS74_1082	ENOG4105K4H	Nlp p60 protein
WS74_1084	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
WS74_1085	ENOG4105CIS	alcohol dehydrogenase
WS74_1087	ENOG4107FQX	Alpha-acetolactate decarboxylase
WS74_1092	ENOG41086FC	50S ribosomal protein l32
WS74_1095	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
WS74_1097	ENOG4105CIE	May be required for sporulation (By similarity)
WS74_1098	ENOG4105CHW	UPF0052 protein
WS74_1102	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
WS74_1107	ENOG4108UJD	30S ribosomal protein S9
WS74_1108	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
WS74_1109	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
WS74_1111	ENOG4108JJB	ABC transporter
WS74_1112	ENOG4108JJB	ABC transporter
WS74_1113	ENOG4106HWW	Acyltransferase family
WS74_1116	ENOG4105DSE	periplasmic solute binding protein
WS74_1117	ENOG4105CC5	ABC transporter
WS74_1118	ENOG4105DIK	(ABC) transporter
WS74_1120	ENOG4105E0X	reductase
WS74_1121	ENOG4105KBC	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
WS74_1122	ENOG4108VZM	50s ribosomal protein L10
WS74_1123	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
WS74_1124	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
WS74_1125	ENOG4105E5V	Participates in transcription elongation, termination and antitermination (By similarity)
WS74_1126	ENOG410683Z	Preprotein translocase SecE subunit
WS74_1127	ENOG4107FTN	50S ribosomal protein L33
WS74_1129	ENOG4105C2N	RNA methyltransferase TrmH family group 3
WS74_1130	ENOG4105KEB	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
WS74_1131	ENOG4105C8N	cysteinyl-tRNA synthetase
WS74_1133	ENOG4107RA1	nh(3)-dependent nad( ) synthetase
WS74_1134	ENOG4105DAP	Nicotinate phosphoribosyltransferase
WS74_1135	ENOG4105D01	(LipO)protein
WS74_1136	ENOG4108JEI	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity)
WS74_1137	ENOG4108UMI	ABC transporter, permease
WS74_1139	ENOG4105CTF	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
WS74_1140	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
WS74_1141	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
WS74_1142	ENOG41067V7	50S ribosomal protein L36
WS74_1143	ENOG4105K9U	however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)
WS74_1145	ENOG4105CGG	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity)
WS74_1146	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
WS74_1148	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
WS74_1150	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
WS74_1151	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
WS74_1152	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
WS74_1153	ENOG4105KAR	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity)
WS74_1154	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
WS74_1155	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
WS74_1156	ENOG41082SA	50s ribosomal protein l29
WS74_1158	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
WS74_1159	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
WS74_1161	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
WS74_1162	ENOG41080UE	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
WS74_1163	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
WS74_1164	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
WS74_1165	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
WS74_1170	ENOG41072GX	Peptidase M22 Glycoprotease
WS74_1171	ENOG4105CMR	udp-glucose 4-epimerase
WS74_1173	ENOG4105CU0	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity)
WS74_1175	ENOG4105X0R	protein from nitrogen regulatory protein P-II
WS74_1176	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
WS74_1178	ENOG4105F3K	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity)
WS74_1179	ENOG410816I	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity)
WS74_1180	ENOG4105C6E	dna polymerase iii
WS74_1182	ENOG4107Y49	methyltransferase
WS74_1189	ENOG4107QW4	alcohol dehydrogenase
WS74_1190	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
WS74_1191	ENOG4108IIJ	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
WS74_1193	ENOG4105KEX	transcriptional regulator, ctsr
WS74_1194	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
WS74_1195	ENOG4105ZMH	deoxynucleoside kinase
WS74_1198	ENOG4105KNM	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
WS74_1199	ENOG4105C4J	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
WS74_1200	ENOG4105J80	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity)
WS74_1201	ENOG4105CDG	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity)
WS74_1203	ENOG4107ZFM	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity)
WS74_1204	ENOG4105WS6	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
WS74_1205	ENOG4107RFS	it plays a direct role in the translocation of protons across the membrane (By similarity)
WS74_1208	ENOG4105CZ5	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity)
WS74_1209	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
WS74_1210	ENOG4105EK0	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
WS74_1211	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
WS74_1212	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
WS74_1213	ENOG4107104	thymidine kinase
WS74_1214	ENOG4105F1K	Glutamine amidotransferase
WS74_1215	ENOG4105DMS	mur ligase
WS74_1216	ENOG4105DG6	mannose-6-phosphate isomerase
WS74_1222	ENOG4105DU0	nucleoside hydrolase
WS74_1226	ENOG4105BZ1	(ABC) transporter
WS74_1227	ENOG4105BZ1	(ABC) transporter
WS74_1228	ENOG4105C1N	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity)
WS74_1229	ENOG4105DKJ	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
WS74_1230	ENOG4108RG0	uracil-dna glycosylase
WS74_1231	ENOG4105C6Z	Gluconate
WS74_1232	ENOG4105CGK	Exodeoxyribonuclease III
WS74_1233	ENOG4108EKI	Dehydrogenase
WS74_1234	ENOG4105CEU	Arginine dihydrolase
WS74_1235	ENOG4105DBV	ornithine carbamoyltransferase
WS74_1236	ENOG4105D5Q	Arginine ornithine antiporter
WS74_1238	ENOG4105C9K	Endothelin-converting enzyme 1
WS74_1241	ENOG4107QRI	Phosphoketolase
WS74_1242	ENOG4108TZY	GntR Family Transcriptional Regulator
WS74_1243	ENOG4105EST	Metal Dependent Phosphohydrolase
WS74_1249	ENOG4105C5H	ABC transporter
WS74_1251	ENOG4105FDK	ABC transporter
WS74_1253	ENOG4107DA6	Transcriptional regulator
WS74_1254	ENOG410906U	SprT-like
WS74_1258	ENOG4105DUX	Transporter
WS74_1260	ENOG4105BZU	Histidine kinase
WS74_1261	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
WS74_1263	ENOG4105C3G	gtp-binding protein
WS74_1264	ENOG4105VDK	protein, conserved in bacteria
WS74_1265	ENOG4105FA0	parb-like partition protein
WS74_1266	ENOG4107QJE	Chromosome Partitioning Protein
WS74_1268	ENOG4105CEN	a g-specific adenine glycosylase
WS74_1270	ENOG4105US7	Histidine kinase
WS74_1271	ENOG4108STX	response regulator
WS74_1272	ENOG4105CEY	Amp-dependent synthetase and ligase
WS74_1273	ENOG4108IPT	Naphthoate synthase
WS74_1277	ENOG4105VEM	Conserved domain protein
WS74_1278	ENOG4105HDK	L-asparaginase
WS74_1279	ENOG4105CUB	amino acid
WS74_1281	ENOG4105CJH	Alcohol dehydrogenase zinc-binding domain protein
WS74_1283	ENOG4105D8C	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity)
WS74_1291	ENOG4107U9W	Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S- specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX (By similarity)
WS74_1294	ENOG4107URF	beta-phospho-glucomutase
WS74_1295	ENOG4105C71	hydrolase family 65, central catalytic
WS74_1296	ENOG4105C5Y	PTS System
WS74_1297	ENOG4108IIZ	The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane
WS74_1298	ENOG4107414	GntR family transcriptional regulator
WS74_1300	ENOG4105ECB	domain protein
WS74_1301	ENOG41062ES	Transcriptional regulator
WS74_1304	ENOG41067QW	Transcriptional regulator
WS74_1309	ENOG4105C85	amino acid
WS74_1310	ENOG4105C02	permease
WS74_1312	ENOG4105EAB	amino acid AbC transporter
WS74_1313	ENOG4105E5Q	amino acid AbC transporter
WS74_1314	ENOG4105CDA	abc transporter atp-binding protein
WS74_1317	ENOG41066UM	arsR family transcriptional regulator
WS74_1318	ENOG4105C59	p-type ATPase
WS74_1319	ENOG4108IND	Tetr family transcriptional regulator
WS74_1320	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
WS74_1321	ENOG4105BZ4	penicillin-binding protein
WS74_1322	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
WS74_1324	ENOG4105C7K	acetolactate synthase
WS74_1326	ENOG4105EMU	Dehydrogenase
WS74_1327	ENOG4105I9P	Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity)
WS74_1328	ENOG4105CV8	reductase
WS74_1329	ENOG4105KVH	Transcriptional regulator
WS74_1330	ENOG4105K85	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity)
WS74_1334	ENOG4108UMW	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
WS74_1336	ENOG4108UXA	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity)
WS74_1337	ENOG4105C85	amino acid
WS74_1338	ENOG4107ZYR	domain protein
WS74_1339	ENOG4105C3F	Signal peptidase i
WS74_1340	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins