locus-tag	class	description
H3N00_00015	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H3N00_00020	COG0531	amino acid
H3N00_00035	COG1902	pentaerythritol trinitrate reductase activity
H3N00_00040	COG0626	cystathionine gamma-synthase activity
H3N00_00060	COG2244	polysaccharide biosynthetic process
H3N00_00070	COG0438	transferase activity, transferring glycosyl groups
H3N00_00075	COG0495	leucyl-tRNA aminoacylation
H3N00_00080	COG0671	phosphoesterase, PA-phosphatase related
H3N00_00090	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H3N00_00115	COG2723	6-phospho-beta-galactosidase activity
H3N00_00135	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
H3N00_00145	COG0024	Methionine aminopeptidase
H3N00_00155	COG1316	TRANSCRIPTIONal
H3N00_00165	COG2205	protein histidine kinase activity
H3N00_00170	COG0745	RESPONSE REGULATOR receiver
H3N00_00175	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H3N00_00190	COG2207	Transcriptional regulator
H3N00_00210	COG0308	aminopeptidase N
H3N00_00215	COG0833	amino acid
H3N00_00220	COG2040	homocysteine
H3N00_00225	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H3N00_00230	COG0542	response to heat
H3N00_00235	COG0308	aminopeptidase N
H3N00_00250	COG0395	ABC-type sugar transport system, permease component
H3N00_00255	COG1175	transmembrane transport
H3N00_00260	COG3842	ATPase activity
H3N00_00310	COG2814	Major facilitator Superfamily
H3N00_00335	COG1914	H( )-stimulated, divalent metal cation uptake system
H3N00_00405	COG0438	transferase activity, transferring glycosyl groups
H3N00_00435	COG2084	Dehydrogenase
H3N00_00440	COG1028	Short-chain dehydrogenase reductase Sdr
H3N00_00450	COG1620	l-lactate permease
H3N00_00455	COG4989	oxidoreductase activity
H3N00_00460	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
H3N00_00465	COG2233	PERMEase
H3N00_00480	COG1956	GAF domain-containing protein
H3N00_00495	COG1132	(ABC) transporter
H3N00_00500	COG1132	(ABC) transporter
H3N00_00505	COG0747	negative chemotaxis
H3N00_00510	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H3N00_00515	COG0601	transmembrane transport
H3N00_00520	COG4608	Belongs to the ABC transporter superfamily
H3N00_00525	COG0444	Belongs to the ABC transporter superfamily
H3N00_00530	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
H3N00_00535	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
H3N00_00540	COG2190	(PTS) system
H3N00_00540	COG2211	Major facilitator Superfamily
H3N00_00555	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H3N00_00560	COG0436	Aminotransferase
H3N00_00570	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H3N00_00575	COG2723	6-phospho-beta-galactosidase activity
H3N00_00580	COG2723	6-phospho-beta-galactosidase activity
H3N00_00585	COG1447	Phosphotransferase system cellobiose-specific component IIA
H3N00_00590	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H3N00_00595	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H3N00_00610	COG1216	Glycosyl transferase, family 2
H3N00_00625	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
H3N00_00680	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
H3N00_00685	COG1737	Transcriptional regulator
H3N00_00695	COG0656	L-ascorbic acid biosynthetic process
H3N00_00700	COG2261	transglycosylase associated protein
H3N00_00765	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
H3N00_00770	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
H3N00_00785	COG0037	tRNA processing
H3N00_00795	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
H3N00_00800	COG2244	polysaccharide biosynthetic process
H3N00_00805	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
H3N00_00810	COG0193	aminoacyl-tRNA hydrolase activity
H3N00_00820	COG0058	SHG alpha-glucan phosphorylase activity
H3N00_00825	COG0297	glycogen (starch) synthase activity
H3N00_00830	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
H3N00_00840	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
H3N00_00850	COG1511	domain protein
H3N00_00850	COG1511	domain protein
H3N00_00855	COG1309	transcriptional regulator
H3N00_00870	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H3N00_00875	COG0477	Major facilitator Superfamily
H3N00_00885	COG0667	Aldo Keto reductase
H3N00_00895	COG2115	Belongs to the xylose isomerase family
H3N00_00905	COG2211	Major facilitator Superfamily
H3N00_00910	COG3507	Belongs to the glycosyl hydrolase 43 family
H3N00_00935	COG2818	Glycosylase
H3N00_00940	COG1968	undecaprenyl-diphosphatase activity
H3N00_00955	COG1695	Transcriptional regulator
H3N00_00960	COG1983	PspC domain protein
H3N00_00965	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
H3N00_00990	COG0737	Belongs to the 5'-nucleotidase family
H3N00_01005	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
H3N00_01020	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H3N00_01020	COG1263	PTS System
H3N00_01025	COG1316	TRANSCRIPTIONal
H3N00_01035	COG2131	deaminase
H3N00_01040	COG4466	Protein conserved in bacteria
H3N00_01045	COG1253	flavin adenine dinucleotide binding
H3N00_01050	COG1253	flavin adenine dinucleotide binding
H3N00_01055	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
H3N00_01060	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
H3N00_01065	COG0084	hydrolase, TatD family'
H3N00_01075	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H3N00_01075	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H3N00_01135	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
H3N00_01155	COG1368	sulfuric ester hydrolase activity
H3N00_01160	COG2153	protein acetylation
H3N00_01175	COG0187	DNA topoisomerase II activity
H3N00_01180	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
H3N00_01185	COG2501	S4 domain
H3N00_01190	COG0592	DNA-directed DNA polymerase activity
H3N00_01195	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
H3N00_01200	COG0230	Belongs to the bacterial ribosomal protein bL34 family
H3N00_01205	COG0594	ribonuclease P activity
H3N00_01210	COG0706	membrane insertase activity
H3N00_01220	COG1120	ATPase activity
H3N00_01230	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H3N00_01245	COG0569	domain protein
H3N00_01250	COG1113	amino acid transport
H3N00_01270	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H3N00_01280	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H3N00_01285	COG0446	pyridine nucleotide-disulphide oxidoreductase
H3N00_01295	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
H3N00_01300	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H3N00_01310	COG1136	(ABC) transporter
H3N00_01315	COG0577	efflux transmembrane transporter activity
H3N00_01320	COG1033	growth of symbiont in host cell
H3N00_01320	COG2409	Drug exporters of the RND superfamily
H3N00_01325	COG0561	phosphatase activity
H3N00_01335	COG0328	RNA-DNA hybrid ribonuclease activity
H3N00_01355	COG3152	Membrane
H3N00_01360	COG2252	PERMEase
H3N00_01400	COG1881	PFAM PEBP family protein
H3N00_01415	COG2801	Transposase and inactivated derivatives
H3N00_01425	COG1476	TRANSCRIPTIONal
H3N00_01455	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
H3N00_01455	COG0517	IMP dehydrogenase activity
H3N00_01460	COG2723	6-phospho-beta-galactosidase activity
H3N00_01490	COG0697	spore germination
H3N00_01505	COG0561	phosphatase activity
H3N00_01510	COG0561	phosphatase activity
H3N00_01520	COG1744	ABC transporter substrate-binding protein PnrA-like
H3N00_01525	COG0137	argininosuccinate synthase activity
H3N00_01530	COG0165	Argininosuccinate lyase
H3N00_01535	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
H3N00_01540	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
H3N00_01545	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
H3N00_01550	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H3N00_01555	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
H3N00_01560	COG0505	Belongs to the CarA family
H3N00_01565	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
H3N00_01585	COG1131	(ABC) transporter
H3N00_01595	COG0789	Transcriptional regulator
H3N00_01600	COG1028	Short-chain dehydrogenase reductase Sdr
H3N00_01610	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H3N00_01620	COG0697	spore germination
H3N00_01645	COG1846	Transcriptional regulator
H3N00_01650	COG1132	(ABC) transporter
H3N00_01660	COG0656	L-ascorbic acid biosynthetic process
H3N00_01670	COG4619	ABC transporter
H3N00_01675	COG0390	transport system, permease component
H3N00_01685	COG1131	(ABC) transporter
H3N00_01695	COG1126	abc transporter atp-binding protein
H3N00_01700	COG0765	amino acid transport
H3N00_01705	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H3N00_01710	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H3N00_01715	COG1254	Belongs to the acylphosphatase family
H3N00_01725	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
H3N00_01725	COG0392	lysyltransferase activity
H3N00_01735	COG0628	permease
H3N00_01765	COG1113	amino acid transport
H3N00_01790	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H3N00_01795	COG0454	-acetyltransferase
H3N00_01795	COG0456	acetyltransferase
H3N00_01805	COG2855	membrane
H3N00_01815	COG2855	membrane
H3N00_01820	COG0583	DNA-binding transcription factor activity
H3N00_01830	COG2070	2-Nitropropane dioxygenase
H3N00_01850	COG0531	amino acid
H3N00_01860	COG3223	Belongs to the PsiE family
H3N00_01870	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H3N00_01880	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
H3N00_01890	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
H3N00_01895	COG4166	transmembrane transport
H3N00_01900	COG2267	carboxylic ester hydrolase activity
H3N00_01910	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
H3N00_01925	COG0477	Major facilitator Superfamily
H3N00_01930	COG4975	Glucose uptake
H3N00_01940	COG0531	amino acid
H3N00_01945	COG1113	amino acid transport
H3N00_01950	COG0531	amino acid
H3N00_01955	COG0252	asparaginase activity
H3N00_01960	COG4443	Transcriptional Coactivator p15 (PC4)
H3N00_01970	COG2226	methyltransferase
H3N00_01975	COG1335	isochorismatase
H3N00_01980	COG2050	protein possibly involved in aromatic compounds catabolism
H3N00_01985	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
H3N00_01990	COG0318	PFAM AMP-dependent synthetase and ligase
H3N00_02005	COG0745	RESPONSE REGULATOR receiver
H3N00_02010	COG5002	protein histidine kinase activity
H3N00_02050	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
H3N00_02055	COG1194	a g-specific adenine glycosylase
H3N00_02065	COG0357	Ribosomal RNA small subunit methyltransferase G
H3N00_02070	COG1192	Involved in chromosome partitioning
H3N00_02075	COG1475	DNA binding
H3N00_02080	COG4481	Protein conserved in bacteria
H3N00_02085	COG0012	GTP binding
H3N00_02095	COG0745	RESPONSE REGULATOR receiver
H3N00_02105	COG1686	Belongs to the peptidase S11 family
H3N00_02110	COG2801	Transposase and inactivated derivatives
H3N00_02165	COG3104	oligopeptide transport
H3N00_02170	COG0477	Major facilitator Superfamily
H3N00_02175	COG4975	Glucose uptake
H3N00_02220	COG3091	SprT-like family
H3N00_02225	COG2755	lipolytic protein G-D-S-L family
H3N00_02225	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
H3N00_02230	COG1846	Transcriptional regulator
H3N00_02240	COG1121	(ABC) transporter
H3N00_02245	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H3N00_02250	COG1373	ATPase (AAA superfamily
H3N00_02255	COG0488	(ABC) transporter
H3N00_02260	COG0534	Mate efflux family protein
H3N00_02275	COG3940	Belongs to the glycosyl hydrolase 43 family
H3N00_02295	COG2160	L-arabinose isomerase activity
H3N00_02300	COG0656	L-ascorbic acid biosynthetic process
H3N00_02325	COG0765	amino acid transport
H3N00_02365	COG1215	transferase activity, transferring glycosyl groups
H3N00_02370	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
H3N00_02375	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
H3N00_02390	COG1418	mRNA catabolic process
H3N00_02395	COG2814	Major facilitator Superfamily
H3N00_02400	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H3N00_02405	COG2188	Transcriptional regulator
H3N00_02410	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
H3N00_02420	COG1216	Glycosyl transferase, family 2
H3N00_02445	COG5039	Polysaccharide pyruvyl transferase
H3N00_02495	COG3590	peptidase
H3N00_02505	COG1012	belongs to the aldehyde dehydrogenase family
H3N00_02505	COG1454	alcohol dehydrogenase
H3N00_02515	COG1373	ATPase (AAA superfamily
H3N00_02520	COG0708	Exodeoxyribonuclease III
H3N00_02540	COG0588	phosphoglycerate mutase activity
H3N00_02560	COG1132	(ABC) transporter
H3N00_02565	COG1132	(ABC) transporter
H3N00_02570	COG1373	ATPase (AAA superfamily
H3N00_02615	COG1482	cell wall glycoprotein biosynthetic process
H3N00_02620	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
H3N00_02625	COG3442	glutamine amidotransferase
H3N00_02635	COG1435	thymidine kinase activity
H3N00_02640	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
H3N00_02645	COG2890	protein-(glutamine-N5) methyltransferase activity
H3N00_02650	COG0009	L-threonylcarbamoyladenylate synthase
H3N00_02655	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
H3N00_02660	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
H3N00_02665	COG0702	epimerase
H3N00_02675	COG2233	PERMEase
H3N00_02680	COG0356	it plays a direct role in the translocation of protons across the membrane
H3N00_02685	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
H3N00_02690	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
H3N00_02695	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
H3N00_02700	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
H3N00_02705	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
H3N00_02710	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
H3N00_02715	COG0355	proton-transporting ATP synthase activity, rotational mechanism
H3N00_02720	COG1876	peptidase activity
H3N00_02725	COG1428	Deoxynucleoside kinase
H3N00_02730	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
H3N00_02755	COG4463	regulation of RNA biosynthetic process
H3N00_02760	COG0542	response to heat
H3N00_02765	COG0085	RNA polymerase activity
H3N00_02785	COG1979	alcohol dehydrogenase
H3N00_02810	COG1309	transcriptional regulator
H3N00_02815	COG0500	methyltransferase
H3N00_02860	COG3620	sequence-specific DNA binding
H3N00_02870	COG2807	transmembrane transport
H3N00_02880	COG2813	Specifically methylates the guanine in position
H3N00_02885	COG0590	tRNA wobble adenosine to inosine editing
H3N00_02895	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
H3N00_02920	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
H3N00_02925	COG3870	Protein conserved in bacteria
H3N00_02945	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H3N00_02950	COG1214	PFAM Peptidase M22, glycoprotease
H3N00_02955	COG0456	acetyltransferase
H3N00_02965	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
H3N00_02970	COG0142	geranyltranstransferase activity
H3N00_02975	COG0051	transcription antitermination factor activity, RNA binding
H3N00_02980	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
H3N00_02990	COG0089	rRNA binding
H3N00_02995	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
H3N00_03000	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
H3N00_03005	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
H3N00_03010	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
H3N00_03015	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
H3N00_03020	COG0255	Belongs to the universal ribosomal protein uL29 family
H3N00_03030	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
H3N00_03035	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
H3N00_03040	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
H3N00_03045	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
H3N00_03050	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
H3N00_03055	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
H3N00_03060	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
H3N00_03065	COG1841	ribosomal large subunit assembly
H3N00_03070	COG0200	Binds to the 23S rRNA
H3N00_03085	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
H3N00_03090	COG0257	Belongs to the bacterial ribosomal protein bL36 family
H3N00_03095	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
H3N00_03100	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
H3N00_03105	COG0202	RNA polymerase activity
H3N00_03110	COG0203	ribosomal protein L17
H3N00_03135	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H3N00_03150	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
H3N00_03175	COG0583	DNA-binding transcription factor activity
H3N00_03185	COG1053	succinate dehydrogenase
H3N00_03190	COG0471	metal ion transport
H3N00_03195	COG0039	L-malate dehydrogenase activity
H3N00_03200	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
H3N00_03205	COG0215	cysteine-tRNA ligase activity
H3N00_03210	COG0626	cystathionine gamma-synthase activity
H3N00_03215	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
H3N00_03220	COG1464	Belongs to the NlpA lipoprotein family
H3N00_03225	COG1854	S-ribosylhomocysteine lyase activity
H3N00_03230	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
H3N00_03235	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H3N00_03250	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
H3N00_03255	COG0250	Participates in transcription elongation, termination and antitermination
H3N00_03260	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
H3N00_03265	COG0081	regulation of translation
H3N00_03270	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
H3N00_03275	COG0222	ribosome binding
H3N00_03295	COG2801	Transposase and inactivated derivatives
H3N00_03300	COG1121	(ABC) transporter
H3N00_03305	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H3N00_03310	COG0803	Belongs to the bacterial solute-binding protein 9 family
H3N00_03315	COG1252	NADH dehydrogenase
H3N00_03325	COG1122	ATPase activity
H3N00_03330	COG1122	ATPase activity
H3N00_03340	COG0101	tRNA pseudouridine synthase activity
H3N00_03345	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
H3N00_03370	COG0028	Belongs to the TPP enzyme family
H3N00_03385	COG1573	uracil-dna glycosylase
H3N00_03400	COG0366	Alpha amylase catalytic
H3N00_03410	COG0671	phosphoesterase, PA-phosphatase related
H3N00_03430	COG2814	Major facilitator Superfamily
H3N00_03435	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
H3N00_03450	COG0391	Required for morphogenesis under gluconeogenic growth conditions
H3N00_03455	COG1481	regulation of sporulation
H3N00_03460	COG0740	serine-type endopeptidase activity
H3N00_03475	COG1263	PTS System
H3N00_03475	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H3N00_03485	COG1914	H( )-stimulated, divalent metal cation uptake system
H3N00_03505	COG0039	L-malate dehydrogenase activity
H3N00_03510	COG0028	Belongs to the TPP enzyme family
H3N00_03515	COG3527	Alpha-acetolactate decarboxylase
H3N00_03525	COG1388	LysM domain
H3N00_03525	COG3942	CHAP domain
H3N00_03530	COG0791	NLP P60 protein
H3N00_03540	COG0756	dUTP diphosphatase activity
H3N00_03550	COG4956	integral membrane protein (PIN domain superfamily)
H3N00_03560	COG0653	protein targeting
H3N00_03565	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
H3N00_03580	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H3N00_03590	COG1733	regulation of RNA biosynthetic process
H3N00_03595	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
H3N00_03600	COG0072	phenylalanine-tRNA ligase activity
H3N00_03600	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H3N00_03605	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
H3N00_03610	COG0514	ATP-dependent DNA helicase (RecQ)
H3N00_03615	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H3N00_03625	COG0768	penicillin binding
H3N00_03630	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
H3N00_03645	COG1940	carbohydrate kinase activity
H3N00_03660	COG3942	CHAP domain
H3N00_03680	COG0584	glycerophosphoryl diester phosphodiesterase
H3N00_03690	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
H3N00_03695	COG0789	Transcriptional regulator
H3N00_03700	COG0174	glutamine synthetase
H3N00_03725	COG0261	This protein binds to 23S rRNA in the presence of protein L20
H3N00_03730	COG0211	Belongs to the bacterial ribosomal protein bL27 family
H3N00_03735	COG1472	Belongs to the glycosyl hydrolase 3 family
H3N00_03765	COG0778	Nitroreductase
H3N00_03770	COG1169	isochorismate synthase
H3N00_03775	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
H3N00_03780	COG0596	Alpha beta hydrolase
H3N00_03785	COG4948	Mandelate Racemase Muconate Lactonizing
H3N00_03815	COG0737	Belongs to the 5'-nucleotidase family
H3N00_03820	COG4470	Protein conserved in bacteria
H3N00_03825	COG0647	UMP catabolic process
H3N00_03830	COG4166	transmembrane transport
H3N00_03835	COG0673	inositol 2-dehydrogenase activity
H3N00_03870	COG0573	inorganic phosphate transmembrane transporter activity
H3N00_03875	COG0581	inorganic phosphate transmembrane transporter activity
H3N00_03880	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H3N00_03885	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H3N00_03890	COG0704	Plays a role in the regulation of phosphate uptake
H3N00_03895	COG2137	regulation of response to DNA damage stimulus
H3N00_03925	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
H3N00_03935	COG5506	Protein of unknown function (DUF1694)
H3N00_03945	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
H3N00_04065	COG1272	protein, Hemolysin III
H3N00_04095	COG0525	valine-tRNA ligase activity
H3N00_04105	COG0285	dihydrofolate synthase activity
H3N00_04135	COG0488	(ABC) transporter
H3N00_04140	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
H3N00_04145	COG0459	protein refolding
H3N00_04150	COG0531	amino acid
H3N00_04160	COG1181	Belongs to the D-alanine--D-alanine ligase family
H3N00_04165	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
H3N00_04170	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
H3N00_04180	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
H3N00_04185	COG1713	HD superfamily hydrolase involved in NAD metabolism
H3N00_04190	COG0799	negative regulation of ribosome biogenesis
H3N00_04195	COG2226	methyltransferase
H3N00_04200	COG1323	Belongs to the UPF0348 family
H3N00_04210	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
H3N00_04215	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
H3N00_04315	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
H3N00_04320	COG3764	Sortase (surface protein transpeptidase)
H3N00_04325	COG0363	glucosamine-6-phosphate deaminase activity
H3N00_04330	COG0776	regulation of translation
H3N00_04340	COG0577	efflux transmembrane transporter activity
H3N00_04345	COG1136	(ABC) transporter
H3N00_04360	COG4720	Psort location CytoplasmicMembrane, score
H3N00_04365	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
H3N00_04370	COG1570	exodeoxyribonuclease VII activity
H3N00_04380	COG0142	geranyltranstransferase activity
H3N00_04385	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
H3N00_04390	COG1438	arginine binding
H3N00_04395	COG0497	DNA recombination
H3N00_04405	COG0194	GDP metabolic process
H3N00_04415	COG0586	Pfam SNARE associated Golgi protein
H3N00_04420	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H3N00_04425	COG1098	S1 RNA binding domain
H3N00_04540	COG4684	Psort location CytoplasmicMembrane, score
H3N00_04545	COG1271	oxidase subunit
H3N00_04550	COG1294	oxidase, subunit
H3N00_04555	COG4988	ABC transporter
H3N00_04560	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
H3N00_04565	COG1705	Flagellar rod assembly protein muramidase FlgJ
H3N00_04565	COG1388	LysM domain
H3N00_04570	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
H3N00_04585	COG1278	Cold shock
H3N00_04590	COG0494	nUDIX hydrolase
H3N00_04600	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
H3N00_04605	COG0346	lactoylglutathione lyase activity
H3N00_04610	COG0400	carboxylic ester hydrolase activity
H3N00_04630	COG0741	lytic transglycosylase activity
H3N00_04650	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
H3N00_04655	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H3N00_04660	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H3N00_04670	COG4120	Belongs to the binding-protein-dependent transport system permease family
H3N00_04680	COG0038	chloride channel
H3N00_04685	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
H3N00_04690	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
H3N00_04695	COG1307	EDD domain protein, DegV family
H3N00_04700	COG1263	PTS System
H3N00_04700	COG2190	(PTS) system
H3N00_04700	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H3N00_04715	COG2003	Belongs to the UPF0758 family
H3N00_04720	COG1077	Cell shape determining protein MreB Mrl
H3N00_04730	COG3338	carbonate dehydratase activity
H3N00_04740	COG0765	amino acid transport
H3N00_04745	COG1126	abc transporter atp-binding protein
H3N00_04755	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H3N00_04755	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H3N00_04760	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
H3N00_04765	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
H3N00_04770	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
H3N00_04775	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H3N00_04780	COG0047	phosphoribosylformylglycinamidine synthase activity
H3N00_04785	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H3N00_04795	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
H3N00_04800	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
H3N00_04805	COG0138	bifunctional purine biosynthesis protein purh
H3N00_04810	COG0151	Belongs to the GarS family
H3N00_04815	COG2759	Belongs to the formate--tetrahydrofolate ligase family
H3N00_04835	COG0446	pyridine nucleotide-disulphide oxidoreductase
H3N00_04855	COG0833	amino acid
H3N00_04865	COG2264	protein methyltransferase activity
H3N00_04870	COG1385	rRNA (uridine-N3-)-methyltransferase activity
H3N00_04880	COG2001	Belongs to the MraZ family
H3N00_04885	COG0275	rRNA processing
H3N00_04900	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H3N00_04905	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
H3N00_04910	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
H3N00_04915	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
H3N00_04920	COG0849	cell division
H3N00_04930	COG1799	cell septum assembly
H3N00_04945	COG3599	regulation of cell shape
H3N00_04965	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H3N00_04970	COG0217	transcriptional regulatory protein
H3N00_04975	COG2252	PERMEase
H3N00_04980	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H3N00_05020	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
H3N00_05025	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
H3N00_05030	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
H3N00_05035	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H3N00_05035	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
H3N00_05040	COG0631	protein serine/threonine phosphatase activity
H3N00_05045	COG0515	serine threonine protein kinase
H3N00_05045	COG2815	serine threonine protein kinase
H3N00_05050	COG1162	GTPase activity
H3N00_05055	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
H3N00_05065	COG0227	Belongs to the bacterial ribosomal protein bL28 family
H3N00_05075	COG1461	Dihydroxyacetone kinase
H3N00_05085	COG0438	transferase activity, transferring glycosyl groups
H3N00_05095	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
H3N00_05100	COG0416	fatty acid biosynthetic process
H3N00_05105	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H3N00_05110	COG0571	ribonuclease III activity
H3N00_05115	COG1196	nuclear chromosome segregation
H3N00_05120	COG0552	protein localization to endoplasmic reticulum
H3N00_05125	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
H3N00_05130	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
H3N00_05150	COG0228	four-way junction DNA binding
H3N00_05155	COG0582	viral genome integration into host DNA
H3N00_05265	COG0588	phosphoglycerate mutase activity
H3N00_05270	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
H3N00_05275	COG0336	Belongs to the RNA methyltransferase TrmD family
H3N00_05280	COG0335	large ribosomal subunit rRNA binding
H3N00_05290	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
H3N00_05295	COG1942	4-Oxalocrotonate Tautomerase
H3N00_05300	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
H3N00_05310	COG1428	Deoxynucleoside kinase
H3N00_05315	COG1970	mechanosensitive ion channel activity
H3N00_05320	COG0561	phosphatase activity
H3N00_05385	COG3853	Toxic anion resistance protein (TelA)
H3N00_05390	COG1393	Belongs to the ArsC family
H3N00_05395	COG4862	establishment of competence for transformation
H3N00_05400	COG2723	6-phospho-beta-galactosidase activity
H3N00_05405	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H3N00_05410	COG1447	Phosphotransferase system cellobiose-specific component IIA
H3N00_05415	COG2723	6-phospho-beta-galactosidase activity
H3N00_05420	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H3N00_05430	COG1164	Oligoendopeptidase f
H3N00_05435	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
H3N00_05450	COG1609	Transcriptional regulator
H3N00_05455	COG0006	proline dipeptidase activity
H3N00_05530	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
H3N00_05535	COG3425	synthase
H3N00_05550	COG0860	N-Acetylmuramoyl-L-alanine amidase
H3N00_05555	COG0124	histidyl-tRNA synthetase
H3N00_05560	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
H3N00_05575	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
H3N00_05580	COG0828	Belongs to the bacterial ribosomal protein bS21 family
H3N00_05585	COG1610	YqeY-like protein
H3N00_05590	COG1702	phosphate starvation-inducible protein PhoH
H3N00_05595	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
H3N00_05600	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
H3N00_05605	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
H3N00_05610	COG1381	Involved in DNA repair and RecF pathway recombination
H3N00_05625	COG0752	glycyl-tRNA synthetase alpha subunit
H3N00_05630	COG0751	glycine-tRNA ligase activity
H3N00_05650	COG2706	6-phosphogluconolactonase activity
H3N00_05655	COG0628	permease
H3N00_05665	COG1674	ftsk spoiiie
H3N00_05675	COG4152	abc transporter atp-binding protein
H3N00_05680	COG1668	transmembrane transport
H3N00_05690	COG0322	excinuclease ABC activity
H3N00_05700	COG1739	Uncharacterized protein family UPF0029
H3N00_05715	COG0517	IMP dehydrogenase activity
H3N00_05715	COG0516	GMP reductase activity
H3N00_05720	COG0517	IMP dehydrogenase activity
H3N00_05720	COG0516	GMP reductase activity
H3N00_05725	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
H3N00_05730	COG0632	four-way junction helicase activity
H3N00_05735	COG2255	four-way junction helicase activity
H3N00_05740	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
H3N00_05775	COG0343	queuine tRNA-ribosyltransferase activity
H3N00_05780	COG1862	Preprotein translocase
H3N00_05785	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H3N00_05790	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
H3N00_05795	COG0513	Belongs to the DEAD box helicase family
H3N00_05800	COG1929	Belongs to the glycerate kinase type-1 family
H3N00_05805	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
H3N00_05825	COG3906	Belongs to the UPF0473 family
H3N00_05835	COG2333	competence protein COMEC
H3N00_05835	COG0658	competence protein
H3N00_05840	COG1466	dna polymerase III delta subunit
H3N00_05845	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
H3N00_05850	COG0268	Binds directly to 16S ribosomal RNA
H3N00_05875	COG0544	peptidyl-prolyl cis-trans isomerase activity
H3N00_05880	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
H3N00_05885	COG0218	Necessary for normal cell division and for the maintenance of normal septation
H3N00_05905	COG1193	negative regulation of DNA recombination
H3N00_05930	COG3118	belongs to the thioredoxin family
H3N00_05935	COG0187	DNA topoisomerase II activity
H3N00_05940	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
H3N00_05945	COG3527	Alpha-acetolactate decarboxylase
H3N00_05950	COG1473	amidohydrolase
H3N00_05965	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H3N00_05990	COG1434	Gram-negative-bacterium-type cell wall biogenesis
H3N00_05995	COG3201	nicotinamide mononucleotide transporter
H3N00_06030	COG0028	Belongs to the TPP enzyme family
H3N00_06035	COG2801	Transposase and inactivated derivatives
H3N00_06085	COG0277	FAD linked oxidase domain protein
H3N00_06090	COG0436	Aminotransferase
H3N00_06105	COG1464	Belongs to the NlpA lipoprotein family
H3N00_06120	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
H3N00_06125	COG0351	phosphomethylpyrimidine kinase
H3N00_06130	COG0352	thiamine-phosphate diphosphorylase activity
H3N00_06150	COG1028	Short-chain dehydrogenase reductase Sdr
H3N00_06160	COG1940	carbohydrate kinase activity
H3N00_06240	COG0546	phosphoglycolate phosphatase activity
H3N00_06245	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
H3N00_06250	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
H3N00_06260	COG3513	CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
H3N00_06285	COG3513	CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
H3N00_06290	COG1518	maintenance of DNA repeat elements
H3N00_06295	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
H3N00_06310	COG2357	RelA SpoT domain protein
H3N00_06315	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
H3N00_06320	COG0564	pseudouridine synthase activity
H3N00_06325	COG2239	Acts as a magnesium transporter
H3N00_06335	COG0456	acetyltransferase
H3N00_06385	COG2801	Transposase and inactivated derivatives
H3N00_06400	COG2207	Transcriptional regulator
H3N00_06400	COG4753	response regulator
H3N00_06410	COG0384	phenazine biosynthesis protein PhzF
H3N00_06420	COG1621	beta-fructofuranosidase activity
H3N00_06440	COG1033	growth of symbiont in host cell
H3N00_06440	COG2409	Drug exporters of the RND superfamily
H3N00_06455	COG4684	Psort location CytoplasmicMembrane, score
H3N00_06470	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
H3N00_06475	COG0738	Major facilitator superfamily
H3N00_06480	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
H3N00_06510	COG1304	FMN binding
H3N00_06525	COG0779	Required for maturation of 30S ribosomal subunits
H3N00_06530	COG0195	Participates in both transcription termination and antitermination
H3N00_06535	COG2740	Nucleic-acid-binding protein implicated in transcription termination
H3N00_06545	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
H3N00_06550	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
H3N00_06555	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
H3N00_06570	COG0196	riboflavin kinase activity
H3N00_06575	COG1293	RNA-binding protein homologous to eukaryotic snRNP
H3N00_06580	COG3142	Participates in the control of copper homeostasis
H3N00_06595	COG2270	Major facilitator Superfamily
H3N00_06600	COG1307	EDD domain protein, DegV family
H3N00_06605	COG1307	EDD domain protein, DegV family
H3N00_06610	COG2755	lipolytic protein G-D-S-L family
H3N00_06620	COG4479	Belongs to the UPF0346 family
H3N00_06630	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
H3N00_06640	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H3N00_06645	COG4974	Belongs to the 'phage' integrase family
H3N00_06655	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
H3N00_06675	COG4175	Glycine betaine
H3N00_06675	COG3448	diguanylate cyclase activity
H3N00_06690	COG0446	pyridine nucleotide-disulphide oxidoreductase
H3N00_06695	COG1464	Belongs to the NlpA lipoprotein family
H3N00_06700	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H3N00_06705	COG1597	lipid kinase activity
H3N00_06710	COG1011	Hydrolase
H3N00_06745	COG0242	peptide deformylase activity
H3N00_06750	COG4476	Belongs to the UPF0223 family
H3N00_06755	COG0483	inositol monophosphate 1-phosphatase activity
H3N00_06765	COG0772	Belongs to the SEDS family
H3N00_06770	COG4471	UPF0298 protein
H3N00_06775	COG0742	ribosomal rna small subunit methyltransferase
H3N00_06780	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
H3N00_06785	COG3480	Lon protease (S16) C-terminal proteolytic domain
H3N00_06790	COG0477	Major facilitator Superfamily
H3N00_06800	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
H3N00_06805	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
H3N00_06810	COG0358	DNA primase activity
H3N00_06815	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H3N00_06845	COG0745	RESPONSE REGULATOR receiver
H3N00_06850	COG5002	protein histidine kinase activity
H3N00_06855	COG0572	uridine kinase
H3N00_06860	COG1363	Peptidase, m42
H3N00_06865	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H3N00_06875	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H3N00_06880	COG0670	Belongs to the BI1 family
H3N00_06885	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H3N00_06885	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H3N00_06890	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
H3N00_06895	COG0237	dephospho-CoA kinase activity
H3N00_06905	COG1484	DNA-dependent DNA replication
H3N00_06920	COG0745	RESPONSE REGULATOR receiver
H3N00_06925	COG5002	protein histidine kinase activity
H3N00_06935	COG3942	CHAP domain
H3N00_06935	COG1705	Flagellar rod assembly protein muramidase FlgJ
H3N00_06940	COG2801	Transposase and inactivated derivatives
H3N00_06975	COG0706	membrane insertase activity
H3N00_06980	COG1028	Short-chain dehydrogenase reductase Sdr
H3N00_06985	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
H3N00_06995	COG1304	FMN binding
H3N00_07015	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H3N00_07015	COG1199	ATP-dependent helicase activity
H3N00_07025	COG0017	Asparaginyl-tRNA synthetase
H3N00_07030	COG3935	DnaD domain protein
H3N00_07040	COG3331	DNA recombination
H3N00_07045	COG4474	Belongs to the UPF0398 family
H3N00_07050	COG3599	regulation of cell shape
H3N00_07060	COG0116	Belongs to the methyltransferase superfamily
H3N00_07070	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
H3N00_07090	COG0556	nucleotide-excision repair
H3N00_07100	COG0439	Biotin carboxylase
H3N00_07105	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
H3N00_07115	COG3104	oligopeptide transport
H3N00_07120	COG0363	glucosamine-6-phosphate deaminase activity
H3N00_07130	COG0537	adenosine 5'-monophosphoramidase activity
H3N00_07135	COG1131	(ABC) transporter
H3N00_07145	COG0220	tRNA (guanine-N7-)-methyltransferase activity
H3N00_07150	COG1719	4-vinyl reductase, 4VR
H3N00_07155	COG1397	ADP-ribosylglycohydrolase
H3N00_07200	COG0446	pyridine nucleotide-disulphide oxidoreductase
H3N00_07205	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
H3N00_07210	COG1349	DNA-binding transcription factor activity
H3N00_07215	COG1105	Belongs to the carbohydrate kinase PfkB family
H3N00_07220	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H3N00_07220	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H3N00_07220	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H3N00_07230	COG1609	Transcriptional regulator
H3N00_07240	COG0306	phosphate transporter
H3N00_07255	COG2723	6-phospho-beta-galactosidase activity
H3N00_07275	COG0531	amino acid
H3N00_07285	COG0481	GTPase activity
H3N00_07320	COG1028	Short-chain dehydrogenase reductase Sdr
H3N00_07325	COG4708	membrane
H3N00_07335	COG0531	amino acid
H3N00_07340	COG4221	oxidoreductase activity
H3N00_07360	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H3N00_07375	COG1136	(ABC) transporter
H3N00_07380	COG0577	efflux transmembrane transporter activity
H3N00_07405	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
H3N00_07415	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
H3N00_07420	COG0267	Belongs to the bacterial ribosomal protein bL33 family
H3N00_07430	COG2801	Transposase and inactivated derivatives
H3N00_07460	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
H3N00_07465	COG2384	SAM-dependent methyltransferase
H3N00_07470	COG0071	Belongs to the small heat shock protein (HSP20) family
H3N00_07475	COG0457	Tetratricopeptide repeat
H3N00_07520	COG0419	ATPase involved in DNA repair
H3N00_07525	COG0420	3'-5' exonuclease activity
H3N00_07535	COG2807	transmembrane transport
H3N00_07540	COG4720	Psort location CytoplasmicMembrane, score
H3N00_07545	COG0351	phosphomethylpyrimidine kinase
H3N00_07555	COG1160	GTP binding
H3N00_07560	COG0539	negative regulation of cytoplasmic translation
H3N00_07565	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
H3N00_07575	COG0514	ATP-dependent DNA helicase (RecQ)
H3N00_07585	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
H3N00_07600	COG1187	pseudouridine synthase activity
H3N00_07605	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
H3N00_07610	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
H3N00_07625	COG2996	Protein conserved in bacteria
H3N00_07635	COG0475	glutathione-regulated potassium exporter activity
H3N00_07645	COG1490	D-aminoacyl-tRNA deacylase activity
H3N00_07650	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H3N00_07655	COG0587	DNA-directed DNA polymerase activity
H3N00_07665	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
H3N00_07670	COG0488	(ABC) transporter
H3N00_07675	COG0617	tRNA 3'-terminal CCA addition
H3N00_07680	COG1136	(ABC) transporter
H3N00_07695	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H3N00_07700	COG0004	ammonium transporteR
H3N00_07710	COG5263	repeat protein
H3N00_07710	COG0366	Alpha amylase catalytic
H3N00_07715	COG1316	TRANSCRIPTIONal
H3N00_07720	COG1216	Glycosyl transferase, family 2
H3N00_07735	COG1442	glycosyl transferase family 8
H3N00_07735	COG1216	Glycosyl transferase, family 2
H3N00_07745	COG0438	transferase activity, transferring glycosyl groups
H3N00_07750	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H3N00_07755	COG0489	protein tyrosine kinase activity
H3N00_07770	COG0233	cytoplasmic translational termination
H3N00_07775	COG0528	UMP kinase activity
H3N00_07780	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
H3N00_07785	COG0052	Belongs to the universal ribosomal protein uS2 family
H3N00_07790	COG2827	Endonuclease containing a URI domain
H3N00_07795	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
H3N00_07800	COG0204	Acyl-transferase
H3N00_07825	COG3763	UPF0154 protein
H3N00_07830	COG4224	UPF0291 protein
H3N00_07835	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H3N00_07855	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
H3N00_07855	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
H3N00_07860	COG1234	tRNA 3'-trailer cleavage
H3N00_07875	COG0484	heat shock protein binding
H3N00_07880	COG0443	Heat shock 70 kDa protein
H3N00_07890	COG1420	regulation of RNA biosynthetic process
H3N00_07920	COG1216	Glycosyl transferase, family 2
H3N00_07930	COG0463	Glycosyl transferase, family 2
H3N00_07940	COG1705	Flagellar rod assembly protein muramidase FlgJ
H3N00_07955	COG0562	UDP-galactopyranose mutase
H3N00_07980	COG0024	Methionine aminopeptidase
H3N00_08000	COG1705	Flagellar rod assembly protein muramidase FlgJ
H3N00_08000	COG1388	LysM domain
H3N00_08015	COG2801	Transposase and inactivated derivatives
H3N00_08045	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
H3N00_08055	COG1682	transport, permease protein
H3N00_08060	COG1388	LysM domain
H3N00_08060	COG1134	teichoic acid transport
H3N00_08070	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
H3N00_08075	COG3475	LICD family
H3N00_08085	COG0463	Glycosyl transferase, family 2
H3N00_08090	COG2246	polysaccharide biosynthetic process
H3N00_08100	COG1216	Glycosyl transferase, family 2
H3N00_08105	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H3N00_08125	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H3N00_08165	COG2801	Transposase and inactivated derivatives
H3N00_08210	COG2309	aminopeptidase activity
H3N00_08225	COG0564	pseudouridine synthase activity
H3N00_08230	COG1278	Cold shock
H3N00_08240	COG2814	Major facilitator Superfamily
H3N00_08245	COG0741	lytic transglycosylase activity
H3N00_08255	COG3973	AAA domain
H3N00_08265	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
H3N00_08270	COG1058	Belongs to the CinA family
H3N00_08270	COG1546	Belongs to the CinA family
H3N00_08275	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
H3N00_08280	COG1426	Protein conserved in bacteria
H3N00_08285	COG0612	Peptidase, M16
H3N00_08290	COG0612	Peptidase, M16
H3N00_08305	COG0028	Belongs to the TPP enzyme family
H3N00_08325	COG4717	serine-type aminopeptidase activity
H3N00_08335	COG3679	Belongs to the UPF0342 family
H3N00_08340	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H3N00_08345	COG1438	arginine binding
H3N00_08365	COG0018	arginyl-trna synthetase
H3N00_08380	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
H3N00_08390	COG1121	(ABC) transporter
H3N00_08400	COG0803	Belongs to the bacterial solute-binding protein 9 family
H3N00_08410	COG1597	lipid kinase activity
H3N00_08415	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H3N00_08420	COG0154	amidase activity
H3N00_08425	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H3N00_08430	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
H3N00_08430	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
H3N00_08440	COG2936	dipeptidyl-peptidase activity
H3N00_08455	COG1695	Transcriptional regulator
H3N00_08465	COG1914	H( )-stimulated, divalent metal cation uptake system
H3N00_08485	COG0667	Aldo Keto reductase
H3N00_08490	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H3N00_08495	COG4721	ABC-type cobalt transport system, permease component
H3N00_08500	COG1122	ATPase activity
H3N00_08515	COG0710	3-dehydroquinate dehydratase activity
H3N00_08520	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
H3N00_08525	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
H3N00_08530	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
H3N00_08535	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
H3N00_08540	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
H3N00_08545	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
H3N00_08560	COG4684	Psort location CytoplasmicMembrane, score
H3N00_08565	COG0436	Aminotransferase
H3N00_08580	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
H3N00_08585	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
H3N00_08590	COG0436	Aminotransferase
H3N00_08595	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
H3N00_08600	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H3N00_08610	COG2171	N-acyltransferase activity
H3N00_08615	COG0019	diaminopimelate decarboxylase activity
H3N00_08620	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H3N00_08625	COG0527	aspartate kinase activity
H3N00_08635	COG1609	Transcriptional regulator
H3N00_08640	COG0083	homoserine kinase activity
H3N00_08655	COG1321	iron dependent repressor
H3N00_08660	COG3764	Sortase (surface protein transpeptidase)
H3N00_08680	COG0513	Belongs to the DEAD box helicase family
H3N00_08685	COG0673	inositol 2-dehydrogenase activity
H3N00_08690	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H3N00_08715	COG0501	Belongs to the peptidase M48B family
H3N00_08720	COG1704	LemA family
H3N00_08730	COG4115	mRNA cleavage
H3N00_08735	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H3N00_08750	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
H3N00_08760	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
H3N00_08765	COG0439	Biotin carboxylase
H3N00_08780	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H3N00_08785	COG1028	Short-chain dehydrogenase reductase Sdr
H3N00_08790	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
H3N00_08795	COG2070	2-Nitropropane dioxygenase
H3N00_08800	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H3N00_08805	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H3N00_08810	COG1846	Transcriptional regulator
H3N00_08815	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H3N00_08825	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
H3N00_08830	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H3N00_08840	COG0505	Belongs to the CarA family
H3N00_08850	COG0564	pseudouridine synthase activity
H3N00_08860	COG0328	RNA-DNA hybrid ribonuclease activity
H3N00_08870	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
H3N00_08875	COG1113	amino acid transport
H3N00_08890	COG2801	Transposase and inactivated derivatives
H3N00_08990	COG2801	Transposase and inactivated derivatives
H3N00_09005	COG1396	sequence-specific DNA binding
H3N00_09025	COG4974	Belongs to the 'phage' integrase family
H3N00_09040	COG0656	L-ascorbic acid biosynthetic process
H3N00_09050	COG1012	belongs to the aldehyde dehydrogenase family
H3N00_09050	COG1454	alcohol dehydrogenase
H3N00_09055	COG0105	UTP biosynthetic process
H3N00_09065	COG0583	DNA-binding transcription factor activity
H3N00_09070	COG0126	phosphoglycerate kinase activity
H3N00_09120	COG0588	phosphoglycerate mutase activity
H3N00_09130	COG3716	PTS system mannose fructose sorbose family IID component
H3N00_09135	COG3715	PTS system
H3N00_09165	COG1397	ADP-ribosylglycohydrolase
H3N00_09225	COG1368	sulfuric ester hydrolase activity
H3N00_09240	COG0438	transferase activity, transferring glycosyl groups
H3N00_09245	COG0438	transferase activity, transferring glycosyl groups
H3N00_09250	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
H3N00_09255	COG0284	orotidine-5'-phosphate decarboxylase activity
H3N00_09260	COG0167	dihydroorotate dehydrogenase activity
H3N00_09265	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
H3N00_09270	COG0505	Belongs to the CarA family
H3N00_09275	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
H3N00_09280	COG0540	Belongs to the ATCase OTCase family
H3N00_09300	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H3N00_09305	COG4856	YbbR-like protein
H3N00_09320	COG0812	UDP-N-acetylmuramate dehydrogenase activity
H3N00_09325	COG2176	DNA-directed DNA polymerase activity
H3N00_09335	COG0802	atpase or kinase
H3N00_09340	COG0280	phosphate acetyltransferase
H3N00_09345	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
H3N00_09355	COG2076	Multidrug Resistance protein
H3N00_09360	COG2076	Multidrug Resistance protein
H3N00_09365	COG1126	abc transporter atp-binding protein
H3N00_09370	COG0765	amino acid transport
H3N00_09375	COG2814	Major facilitator Superfamily
H3N00_09390	COG0557	exoribonuclease II activity
H3N00_09400	COG2814	Major facilitator Superfamily
H3N00_09405	COG0154	amidase activity
H3N00_09425	COG0149	triose-phosphate isomerase activity
H3N00_09430	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H3N00_09435	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H3N00_09445	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H3N00_09450	COG0492	ferredoxin-NADP+ reductase activity
H3N00_09470	COG1210	Utp--glucose-1-phosphate uridylyltransferase
H3N00_09475	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
H3N00_09480	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
H3N00_09485	COG1950	PFAM Membrane protein of
H3N00_09495	COG0589	response to stress
H3N00_09505	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H3N00_09515	COG1177	transmembrane transport
H3N00_09525	COG3842	ATPase activity
H3N00_09535	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
H3N00_09540	COG0049	tRNA binding
H3N00_09545	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
H3N00_09555	COG4608	Belongs to the ABC transporter superfamily
H3N00_09560	COG0444	Belongs to the ABC transporter superfamily
H3N00_09565	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H3N00_09570	COG0601	transmembrane transport
H3N00_09580	COG0460	homoserine dehydrogenase
H3N00_09585	COG0626	cystathionine gamma-synthase activity
H3N00_09590	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
H3N00_09605	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
H3N00_09610	COG0291	Belongs to the bacterial ribosomal protein bL35 family
H3N00_09625	COG1302	Protein conserved in bacteria
H3N00_09630	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
H3N00_09640	COG2017	converts alpha-aldose to the beta-anomer
H3N00_09650	COG4975	Glucose uptake
H3N00_09670	COG5002	protein histidine kinase activity
H3N00_09670	COG3850	Histidine kinase
H3N00_09675	COG0745	RESPONSE REGULATOR receiver
H3N00_09680	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H3N00_09685	COG0402	S-adenosylhomocysteine deaminase activity
H3N00_09690	COG0673	inositol 2-dehydrogenase activity
H3N00_09695	COG0741	lytic transglycosylase activity
H3N00_09715	COG0668	transmembrane transport
H3N00_09725	COG1126	abc transporter atp-binding protein
H3N00_09730	COG0765	amino acid transport
H3N00_09770	COG0516	GMP reductase activity
H3N00_09855	COG2801	Transposase and inactivated derivatives
H3N00_09910	COG1869	D-ribose catabolic process
H3N00_09915	COG1609	Transcriptional regulator
H3N00_09935	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H3N00_09950	COG1609	Transcriptional regulator
H3N00_09965	COG2223	nitrite transmembrane transporter activity
H3N00_09985	COG1116	anion transmembrane transporter activity
H3N00_09990	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H3N00_10000	COG0285	dihydrofolate synthase activity
H3N00_10005	COG0302	gtp cyclohydrolase
H3N00_10010	COG0302	gtp cyclohydrolase
H3N00_10010	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
H3N00_10025	COG0561	phosphatase activity
H3N00_10035	COG1506	peptidase
H3N00_10035	COG4946	Tricorn protease homolog
H3N00_10035	COG0823	Involved in the tonB-independent uptake of proteins
H3N00_10040	COG1464	Belongs to the NlpA lipoprotein family
H3N00_10055	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H3N00_10070	COG1609	Transcriptional regulator
H3N00_10100	COG0577	efflux transmembrane transporter activity
H3N00_10105	COG1136	(ABC) transporter
H3N00_10110	COG3759	membrane
H3N00_10140	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
H3N00_10145	COG2235	arginine
H3N00_10155	COG2217	Heavy metal translocating P-type atpase
H3N00_10205	COG0438	transferase activity, transferring glycosyl groups
H3N00_10245	COG2814	Major facilitator Superfamily
H3N00_10250	COG2217	Heavy metal translocating P-type atpase
H3N00_10270	COG1309	transcriptional regulator
H3N00_10290	COG3711	transcriptional antiterminator
H3N00_10295	COG2723	6-phospho-beta-galactosidase activity
H3N00_10300	COG1940	carbohydrate kinase activity
H3N00_10325	COG2183	response to ionizing radiation
H3N00_10335	COG2873	o-acetylhomoserine
H3N00_10340	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
H3N00_10345	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
H3N00_10425	COG2176	DNA-directed DNA polymerase activity
H3N00_10430	COG0442	prolyl-tRNA aminoacylation
H3N00_10435	COG0750	zinc metalloprotease
H3N00_10440	COG4589	Belongs to the CDS family
H3N00_10445	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
H3N00_10450	COG0561	phosphatase activity
H3N00_10455	COG2246	polysaccharide biosynthetic process
H3N00_10480	COG1811	Na channel or pump
H3N00_10485	COG1979	alcohol dehydrogenase
H3N00_10495	COG1174	glycine betaine transport
H3N00_10530	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
H3N00_10535	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H3N00_10535	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H3N00_10540	COG0307	riboflavin synthase, alpha
H3N00_10545	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H3N00_10545	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H3N00_10550	COG2076	Multidrug Resistance protein
H3N00_10555	COG2076	Multidrug Resistance protein
H3N00_10565	COG1435	thymidine kinase activity
H3N00_10585	COG2801	Transposase and inactivated derivatives
H3N00_10600	COG1307	EDD domain protein, DegV family
H3N00_10605	COG0656	L-ascorbic acid biosynthetic process
H3N00_10610	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
H3N00_10635	COG4166	transmembrane transport
H3N00_10655	COG2826	transposase and inactivated derivatives, IS30 family
H3N00_10700	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
H3N00_10710	COG2252	PERMEase
H3N00_10720	COG0352	thiamine-phosphate diphosphorylase activity
H3N00_10725	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
H3N00_10735	COG2814	Major facilitator Superfamily
H3N00_10740	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
H3N00_10750	COG2188	Transcriptional regulator
H3N00_10760	COG1136	(ABC) transporter
H3N00_10760	COG0577	efflux transmembrane transporter activity
H3N00_10770	COG0561	phosphatase activity
H3N00_10775	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H3N00_10775	COG2169	Transcriptional regulator
H3N00_10780	COG0561	phosphatase activity
H3N00_10800	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
H3N00_10805	COG0772	Belongs to the SEDS family
H3N00_10815	COG1077	Cell shape determining protein MreB Mrl
H3N00_10820	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
H3N00_10845	COG2801	Transposase and inactivated derivatives
H3N00_10860	COG0446	pyridine nucleotide-disulphide oxidoreductase
H3N00_10870	COG0640	Transcriptional regulator
H3N00_10875	COG0628	permease
H3N00_10880	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
H3N00_10900	COG0386	Belongs to the glutathione peroxidase family
H3N00_10905	COG0588	phosphoglycerate mutase activity
H3N00_10920	COG0492	ferredoxin-NADP+ reductase activity
H3N00_10935	COG1744	ABC transporter substrate-binding protein PnrA-like
H3N00_10945	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
H3N00_10950	COG2832	Protein of unknown function (DUF454)
H3N00_10975	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H3N00_10985	COG2814	Major facilitator Superfamily
H3N00_10990	COG0305	Participates in initiation and elongation during chromosome replication
H3N00_10995	COG0359	binds to the 23S rRNA
H3N00_11005	COG4608	Belongs to the ABC transporter superfamily
H3N00_11010	COG0444	Belongs to the ABC transporter superfamily
H3N00_11015	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H3N00_11020	COG0601	transmembrane transport
H3N00_11030	COG0765	amino acid transport
H3N00_11035	COG0765	amino acid transport
H3N00_11040	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H3N00_11045	COG1126	abc transporter atp-binding protein
H3N00_11060	COG0194	GDP metabolic process
H3N00_11065	COG1268	BioY protein
H3N00_11070	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
H3N00_11070	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
H3N00_11100	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
H3N00_11115	COG3973	AAA domain
H3N00_11135	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
H3N00_11145	COG1696	Membrane protein involved in D-alanine export
H3N00_11165	COG2337	Toxic component of a toxin-antitoxin (TA) module
H3N00_11180	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
H3N00_11185	COG0504	CTP synthase activity
H3N00_11195	COG3343	RNA polymerase activity
H3N00_11200	COG0561	phosphatase activity
H3N00_11205	COG1078	dGTPase activity
H3N00_11215	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H3N00_11220	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
H3N00_11240	COG0745	RESPONSE REGULATOR receiver
H3N00_11270	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
H3N00_11275	COG0629	single-stranded DNA binding
H3N00_11280	COG0360	Binds together with S18 to 16S ribosomal RNA
H3N00_11295	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H3N00_11305	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
H3N00_11310	COG1051	belongs to the nudix hydrolase family
H3N00_11325	COG2814	Major facilitator Superfamily
H3N00_11330	COG1064	alcohol dehydrogenase
H3N00_11335	COG1074	ATP-dependent DNA helicase activity
H3N00_11340	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
H3N00_11345	COG1454	alcohol dehydrogenase
H3N00_11345	COG1012	belongs to the aldehyde dehydrogenase family
H3N00_11355	COG1573	uracil-dna glycosylase
H3N00_11360	COG2801	Transposase and inactivated derivatives
H3N00_11380	COG2017	converts alpha-aldose to the beta-anomer
H3N00_11385	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H3N00_11425	COG0783	Belongs to the Dps family
H3N00_11430	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H3N00_11440	COG2801	Transposase and inactivated derivatives
H3N00_11465	COG2261	transglycosylase associated protein
H3N00_11485	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H3N00_11495	COG0492	ferredoxin-NADP+ reductase activity
H3N00_11505	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H3N00_11510	COG3118	belongs to the thioredoxin family
H3N00_11515	COG0640	Transcriptional regulator
H3N00_11525	COG0489	protein tyrosine kinase activity
H3N00_11550	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
H3N00_11560	COG1088	dTDP-glucose 4,6-dehydratase activity
H3N00_11580	COG3620	sequence-specific DNA binding
H3N00_11610	COG2801	Transposase and inactivated derivatives
H3N00_11630	COG2801	Transposase and inactivated derivatives
H3N00_11640	COG1215	transferase activity, transferring glycosyl groups
H3N00_11655	COG2801	Transposase and inactivated derivatives
H3N00_11665	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family