locus-tag	class	description
L1O50_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
L1O50_00010	COG0592	DNA-directed DNA polymerase activity
L1O50_00015	COG2501	S4 domain
L1O50_00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
L1O50_00025	COG0187	DNA topoisomerase II activity
L1O50_00040	COG2153	protein acetylation
L1O50_00045	COG1368	sulfuric ester hydrolase activity
L1O50_00065	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
L1O50_00125	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L1O50_00125	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L1O50_00135	COG0084	hydrolase, TatD family'
L1O50_00140	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
L1O50_00145	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
L1O50_00150	COG1253	flavin adenine dinucleotide binding
L1O50_00155	COG1253	flavin adenine dinucleotide binding
L1O50_00160	COG4466	Protein conserved in bacteria
L1O50_00165	COG2131	deaminase
L1O50_00175	COG1316	TRANSCRIPTIONal
L1O50_00180	COG1263	PTS System
L1O50_00180	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
L1O50_00195	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
L1O50_00210	COG0737	Belongs to the 5'-nucleotidase family
L1O50_00215	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
L1O50_00220	COG1983	PspC domain protein
L1O50_00225	COG1695	Transcriptional regulator
L1O50_00240	COG1968	undecaprenyl-diphosphatase activity
L1O50_00245	COG2818	Glycosylase
L1O50_00270	COG3507	Belongs to the glycosyl hydrolase 43 family
L1O50_00275	COG2211	Major facilitator Superfamily
L1O50_00285	COG2115	Belongs to the xylose isomerase family
L1O50_00295	COG0667	Aldo Keto reductase
L1O50_00310	COG0477	Major facilitator Superfamily
L1O50_00315	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
L1O50_00330	COG1309	transcriptional regulator
L1O50_00335	COG1511	domain protein
L1O50_00335	COG1511	domain protein
L1O50_00345	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
L1O50_00355	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
L1O50_00360	COG0297	glycogen (starch) synthase activity
L1O50_00365	COG0058	SHG alpha-glucan phosphorylase activity
L1O50_00375	COG0193	aminoacyl-tRNA hydrolase activity
L1O50_00380	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
L1O50_00385	COG2244	polysaccharide biosynthetic process
L1O50_00390	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
L1O50_00400	COG0037	tRNA processing
L1O50_00415	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
L1O50_00420	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
L1O50_00485	COG2261	transglycosylase associated protein
L1O50_00490	COG0656	L-ascorbic acid biosynthetic process
L1O50_00500	COG1737	Transcriptional regulator
L1O50_00505	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
L1O50_00550	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
L1O50_00565	COG1216	Glycosyl transferase, family 2
L1O50_00585	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
L1O50_00590	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
L1O50_00595	COG1447	Phosphotransferase system cellobiose-specific component IIA
L1O50_00600	COG2723	6-phospho-beta-galactosidase activity
L1O50_00605	COG2723	6-phospho-beta-galactosidase activity
L1O50_00610	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
L1O50_00620	COG0436	Aminotransferase
L1O50_00640	COG2211	Major facilitator Superfamily
L1O50_00640	COG2190	(PTS) system
L1O50_00645	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
L1O50_00650	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
L1O50_00655	COG0444	Belongs to the ABC transporter superfamily
L1O50_00660	COG4608	Belongs to the ABC transporter superfamily
L1O50_00665	COG0601	transmembrane transport
L1O50_00670	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
L1O50_00675	COG0747	negative chemotaxis
L1O50_00685	COG1132	(ABC) transporter
L1O50_00700	COG1956	GAF domain-containing protein
L1O50_00715	COG2233	PERMEase
L1O50_00720	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
L1O50_00725	COG4989	oxidoreductase activity
L1O50_00730	COG1620	l-lactate permease
L1O50_00740	COG1028	Short-chain dehydrogenase reductase Sdr
L1O50_00745	COG2084	Dehydrogenase
L1O50_00775	COG0438	transferase activity, transferring glycosyl groups
L1O50_00885	COG3842	ATPase activity
L1O50_00890	COG1175	transmembrane transport
L1O50_00895	COG0395	ABC-type sugar transport system, permease component
L1O50_00910	COG0542	response to heat
L1O50_00915	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L1O50_00920	COG2040	homocysteine
L1O50_00925	COG0833	amino acid
L1O50_00930	COG0308	aminopeptidase N
L1O50_00950	COG2207	Transcriptional regulator
L1O50_00965	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
L1O50_00970	COG0745	RESPONSE REGULATOR receiver
L1O50_00975	COG2205	protein histidine kinase activity
L1O50_00985	COG1316	TRANSCRIPTIONal
L1O50_00995	COG0024	Methionine aminopeptidase
L1O50_01005	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
L1O50_01015	COG2801	Transposase and inactivated derivatives
L1O50_01045	COG2723	6-phospho-beta-galactosidase activity
L1O50_01070	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
L1O50_01080	COG0671	phosphoesterase, PA-phosphatase related
L1O50_01085	COG0495	leucyl-tRNA aminoacylation
L1O50_01090	COG0438	transferase activity, transferring glycosyl groups
L1O50_01100	COG2244	polysaccharide biosynthetic process
L1O50_01120	COG0626	cystathionine gamma-synthase activity
L1O50_01125	COG1902	pentaerythritol trinitrate reductase activity
L1O50_01135	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
L1O50_01140	COG0531	amino acid
L1O50_01145	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
L1O50_01160	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
L1O50_01165	COG1074	ATP-dependent DNA helicase activity
L1O50_01170	COG1064	alcohol dehydrogenase
L1O50_01175	COG2814	Major facilitator Superfamily
L1O50_01190	COG1051	belongs to the nudix hydrolase family
L1O50_01195	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
L1O50_01205	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
L1O50_01220	COG0360	Binds together with S18 to 16S ribosomal RNA
L1O50_01225	COG0629	single-stranded DNA binding
L1O50_01230	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
L1O50_01260	COG0745	RESPONSE REGULATOR receiver
L1O50_01280	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
L1O50_01285	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
L1O50_01295	COG1078	dGTPase activity
L1O50_01300	COG0561	phosphatase activity
L1O50_01305	COG3343	RNA polymerase activity
L1O50_01315	COG0504	CTP synthase activity
L1O50_01320	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
L1O50_01335	COG2337	Toxic component of a toxin-antitoxin (TA) module
L1O50_01355	COG1696	Membrane protein involved in D-alanine export
L1O50_01365	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
L1O50_01385	COG3973	AAA domain
L1O50_01400	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
L1O50_01405	COG2211	Major facilitator Superfamily
L1O50_01430	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
L1O50_01430	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
L1O50_01435	COG1268	BioY protein
L1O50_01440	COG0194	GDP metabolic process
L1O50_01455	COG1126	abc transporter atp-binding protein
L1O50_01460	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L1O50_01465	COG0765	amino acid transport
L1O50_01470	COG0765	amino acid transport
L1O50_01475	COG4166	transmembrane transport
L1O50_01480	COG0601	transmembrane transport
L1O50_01485	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
L1O50_01490	COG0444	Belongs to the ABC transporter superfamily
L1O50_01495	COG4608	Belongs to the ABC transporter superfamily
L1O50_01505	COG0359	binds to the 23S rRNA
L1O50_01510	COG0305	Participates in initiation and elongation during chromosome replication
L1O50_01515	COG2814	Major facilitator Superfamily
L1O50_01525	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
L1O50_01550	COG2832	Protein of unknown function (DUF454)
L1O50_01560	COG1744	ABC transporter substrate-binding protein PnrA-like
L1O50_01565	COG1744	ABC transporter substrate-binding protein PnrA-like
L1O50_01580	COG0492	ferredoxin-NADP+ reductase activity
L1O50_01595	COG0588	phosphoglycerate mutase activity
L1O50_01600	COG0386	Belongs to the glutathione peroxidase family
L1O50_01620	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
L1O50_01625	COG0628	permease
L1O50_01630	COG0640	Transcriptional regulator
L1O50_01640	COG0446	pyridine nucleotide-disulphide oxidoreductase
L1O50_01645	COG1744	ABC transporter substrate-binding protein PnrA-like
L1O50_01650	COG3845	ABC transporter
L1O50_01655	COG4603	Belongs to the binding-protein-dependent transport system permease family
L1O50_01660	COG1079	Belongs to the binding-protein-dependent transport system permease family
L1O50_01665	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
L1O50_01670	COG1077	Cell shape determining protein MreB Mrl
L1O50_01680	COG0772	Belongs to the SEDS family
L1O50_01685	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
L1O50_01705	COG0561	phosphatase activity
L1O50_01710	COG2169	Transcriptional regulator
L1O50_01710	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
L1O50_01715	COG0561	phosphatase activity
L1O50_01725	COG1136	(ABC) transporter
L1O50_01725	COG0577	efflux transmembrane transporter activity
L1O50_01735	COG2188	Transcriptional regulator
L1O50_01745	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
L1O50_01750	COG2814	Major facilitator Superfamily
L1O50_01760	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
L1O50_01765	COG0352	thiamine-phosphate diphosphorylase activity
L1O50_01775	COG2252	PERMEase
L1O50_01785	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
L1O50_01790	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
L1O50_01835	COG0604	alcohol dehydrogenase
L1O50_01840	COG4166	transmembrane transport
L1O50_01845	COG1228	amidohydrolase
L1O50_01860	COG2814	Major facilitator Superfamily
L1O50_01865	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
L1O50_01870	COG0656	L-ascorbic acid biosynthetic process
L1O50_01875	COG1307	EDD domain protein, DegV family
L1O50_01890	COG1435	thymidine kinase activity
L1O50_01900	COG2076	Multidrug Resistance protein
L1O50_01905	COG2076	Multidrug Resistance protein
L1O50_01910	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
L1O50_01910	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
L1O50_01920	COG0307	riboflavin synthase, alpha
L1O50_01925	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
L1O50_01925	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
L1O50_01930	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
L1O50_01950	COG1174	glycine betaine transport
L1O50_01960	COG1979	alcohol dehydrogenase
L1O50_01965	COG1811	Na channel or pump
L1O50_01990	COG2246	polysaccharide biosynthetic process
L1O50_01995	COG0561	phosphatase activity
L1O50_02000	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
L1O50_02005	COG4589	Belongs to the CDS family
L1O50_02010	COG0750	zinc metalloprotease
L1O50_02015	COG0442	prolyl-tRNA aminoacylation
L1O50_02020	COG2176	DNA-directed DNA polymerase activity
L1O50_02100	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
L1O50_02105	COG1040	competence protein
L1O50_02110	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
L1O50_02115	COG2873	o-acetylhomoserine
L1O50_02125	COG2183	response to ionizing radiation
L1O50_02150	COG1940	carbohydrate kinase activity
L1O50_02155	COG2723	6-phospho-beta-galactosidase activity
L1O50_02160	COG3711	transcriptional antiterminator
L1O50_02180	COG1309	transcriptional regulator
L1O50_02200	COG2217	Heavy metal translocating P-type atpase
L1O50_02205	COG2814	Major facilitator Superfamily
L1O50_02270	COG0438	transferase activity, transferring glycosyl groups
L1O50_02320	COG2217	Heavy metal translocating P-type atpase
L1O50_02330	COG2235	arginine
L1O50_02335	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
L1O50_02360	COG3759	membrane
L1O50_02365	COG1136	(ABC) transporter
L1O50_02370	COG0577	efflux transmembrane transporter activity
L1O50_02400	COG1609	Transcriptional regulator
L1O50_02415	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
L1O50_02430	COG0246	Mannitol dehydrogenase
L1O50_02435	COG1312	Catalyzes the dehydration of D-mannonate
L1O50_02440	COG1904	glucuronate isomerase
L1O50_02445	COG0800	Aldolase
L1O50_02450	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
L1O50_02460	COG1464	Belongs to the NlpA lipoprotein family
L1O50_02465	COG0823	Involved in the tonB-independent uptake of proteins
L1O50_02465	COG1506	peptidase
L1O50_02465	COG4946	Tricorn protease homolog
L1O50_02480	COG0561	phosphatase activity
L1O50_02525	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
L1O50_02525	COG0302	gtp cyclohydrolase
L1O50_02530	COG0302	gtp cyclohydrolase
L1O50_02535	COG0285	dihydrofolate synthase activity
L1O50_02550	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L1O50_02555	COG1116	anion transmembrane transporter activity
L1O50_02565	COG0318	PFAM AMP-dependent synthetase and ligase
L1O50_02575	COG2223	nitrite transmembrane transporter activity
L1O50_02600	COG1609	Transcriptional regulator
L1O50_02615	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
L1O50_02635	COG1609	Transcriptional regulator
L1O50_02640	COG1869	D-ribose catabolic process
L1O50_02645	COG0738	Major facilitator superfamily
L1O50_02685	COG0494	nUDIX hydrolase
L1O50_02700	COG2801	Transposase and inactivated derivatives
L1O50_02775	COG0516	GMP reductase activity
L1O50_02820	COG0765	amino acid transport
L1O50_02825	COG1126	abc transporter atp-binding protein
L1O50_02835	COG0668	transmembrane transport
L1O50_02855	COG0741	lytic transglycosylase activity
L1O50_02860	COG0673	inositol 2-dehydrogenase activity
L1O50_02865	COG0402	S-adenosylhomocysteine deaminase activity
L1O50_02870	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
L1O50_02875	COG0745	RESPONSE REGULATOR receiver
L1O50_02880	COG5002	protein histidine kinase activity
L1O50_02880	COG3850	Histidine kinase
L1O50_02885	COG4975	Glucose uptake
L1O50_02895	COG2017	converts alpha-aldose to the beta-anomer
L1O50_02905	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
L1O50_02910	COG1302	Protein conserved in bacteria
L1O50_02925	COG0291	Belongs to the bacterial ribosomal protein bL35 family
L1O50_02940	COG1744	ABC transporter substrate-binding protein PnrA-like
L1O50_02950	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
L1O50_02955	COG0626	cystathionine gamma-synthase activity
L1O50_02960	COG0460	homoserine dehydrogenase
L1O50_02970	COG0601	transmembrane transport
L1O50_02975	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
L1O50_02980	COG0444	Belongs to the ABC transporter superfamily
L1O50_02985	COG4608	Belongs to the ABC transporter superfamily
L1O50_02995	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
L1O50_03000	COG0049	tRNA binding
L1O50_03005	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
L1O50_03015	COG3842	ATPase activity
L1O50_03025	COG1177	transmembrane transport
L1O50_03035	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
L1O50_03045	COG0589	response to stress
L1O50_03055	COG1950	PFAM Membrane protein of
L1O50_03060	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
L1O50_03065	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
L1O50_03070	COG1210	Utp--glucose-1-phosphate uridylyltransferase
L1O50_03090	COG0492	ferredoxin-NADP+ reductase activity
L1O50_03095	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
L1O50_03105	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
L1O50_03110	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
L1O50_03115	COG0149	triose-phosphate isomerase activity
L1O50_03135	COG0154	amidase activity
L1O50_03140	COG2814	Major facilitator Superfamily
L1O50_03150	COG0557	exoribonuclease II activity
L1O50_03165	COG2814	Major facilitator Superfamily
L1O50_03170	COG0765	amino acid transport
L1O50_03175	COG1126	abc transporter atp-binding protein
L1O50_03180	COG2076	Multidrug Resistance protein
L1O50_03185	COG2076	Multidrug Resistance protein
L1O50_03195	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
L1O50_03200	COG0280	phosphate acetyltransferase
L1O50_03205	COG0802	atpase or kinase
L1O50_03220	COG0812	UDP-N-acetylmuramate dehydrogenase activity
L1O50_03235	COG4856	YbbR-like protein
L1O50_03240	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
L1O50_03260	COG0540	Belongs to the ATCase OTCase family
L1O50_03265	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
L1O50_03270	COG0505	Belongs to the CarA family
L1O50_03275	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
L1O50_03280	COG0167	dihydroorotate dehydrogenase activity
L1O50_03285	COG0284	orotidine-5'-phosphate decarboxylase activity
L1O50_03290	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
L1O50_03295	COG0438	transferase activity, transferring glycosyl groups
L1O50_03300	COG0438	transferase activity, transferring glycosyl groups
L1O50_03315	COG1368	sulfuric ester hydrolase activity
L1O50_03375	COG1397	ADP-ribosylglycohydrolase
L1O50_03390	COG3715	PTS system
L1O50_03395	COG3716	PTS system mannose fructose sorbose family IID component
L1O50_03405	COG0588	phosphoglycerate mutase activity
L1O50_03455	COG0126	phosphoglycerate kinase activity
L1O50_03460	COG0583	DNA-binding transcription factor activity
L1O50_03470	COG0105	UTP biosynthetic process
L1O50_03475	COG1012	belongs to the aldehyde dehydrogenase family
L1O50_03475	COG1454	alcohol dehydrogenase
L1O50_03485	COG0656	L-ascorbic acid biosynthetic process
L1O50_03510	COG1113	amino acid transport
L1O50_03515	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
L1O50_03520	COG1757	Na H antiporter
L1O50_03525	COG0328	RNA-DNA hybrid ribonuclease activity
L1O50_03535	COG0564	pseudouridine synthase activity
L1O50_03545	COG0505	Belongs to the CarA family
L1O50_03555	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
L1O50_03560	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
L1O50_03570	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
L1O50_03575	COG1846	Transcriptional regulator
L1O50_03580	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
L1O50_03585	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
L1O50_03590	COG2070	2-Nitropropane dioxygenase
L1O50_03595	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
L1O50_03600	COG1028	Short-chain dehydrogenase reductase Sdr
L1O50_03605	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
L1O50_03620	COG0439	Biotin carboxylase
L1O50_03630	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
L1O50_03645	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
L1O50_03650	COG4115	mRNA cleavage
L1O50_03660	COG1704	LemA family
L1O50_03665	COG0501	Belongs to the peptidase M48B family
L1O50_03675	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
L1O50_03680	COG0673	inositol 2-dehydrogenase activity
L1O50_03685	COG0513	Belongs to the DEAD box helicase family
L1O50_03705	COG3764	Sortase (surface protein transpeptidase)
L1O50_03710	COG1321	iron dependent repressor
L1O50_03725	COG0083	homoserine kinase activity
L1O50_03730	COG1609	Transcriptional regulator
L1O50_03740	COG0527	aspartate kinase activity
L1O50_03745	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
L1O50_03755	COG2171	N-acyltransferase activity
L1O50_03765	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L1O50_03770	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
L1O50_03775	COG0436	Aminotransferase
L1O50_03780	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
L1O50_03785	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
L1O50_03820	COG1396	sequence-specific DNA binding
L1O50_03965	COG1783	phage Terminase large subunit
L1O50_03980	COG2801	Transposase and inactivated derivatives
L1O50_04005	COG0436	Aminotransferase
L1O50_04010	COG4684	Psort location CytoplasmicMembrane, score
L1O50_04025	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
L1O50_04030	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
L1O50_04035	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
L1O50_04040	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
L1O50_04045	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
L1O50_04050	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
L1O50_04055	COG0710	3-dehydroquinate dehydratase activity
L1O50_04070	COG0758	DNA mediated transformation
L1O50_04085	COG1122	ATPase activity
L1O50_04090	COG4721	ABC-type cobalt transport system, permease component
L1O50_04095	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
L1O50_04100	COG0667	Aldo Keto reductase
L1O50_04120	COG1914	H( )-stimulated, divalent metal cation uptake system
L1O50_04130	COG1695	Transcriptional regulator
L1O50_04145	COG2936	dipeptidyl-peptidase activity
L1O50_04155	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
L1O50_04155	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
L1O50_04160	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
L1O50_04165	COG0154	amidase activity
L1O50_04170	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
L1O50_04175	COG1597	lipid kinase activity
L1O50_04195	COG1121	(ABC) transporter
L1O50_04205	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
L1O50_04220	COG0018	arginyl-trna synthetase
L1O50_04230	COG1132	(ABC) transporter
L1O50_04245	COG1959	2 iron, 2 sulfur cluster binding
L1O50_04275	COG1438	arginine binding
L1O50_04280	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
L1O50_04285	COG3679	Belongs to the UPF0342 family
L1O50_04300	COG4717	serine-type aminopeptidase activity
L1O50_04320	COG0028	Belongs to the TPP enzyme family
L1O50_04335	COG0612	Peptidase, M16
L1O50_04340	COG0612	Peptidase, M16
L1O50_04345	COG1426	Protein conserved in bacteria
L1O50_04350	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
L1O50_04355	COG1546	Belongs to the CinA family
L1O50_04355	COG1058	Belongs to the CinA family
L1O50_04360	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
L1O50_04370	COG3973	AAA domain
L1O50_04380	COG0741	lytic transglycosylase activity
L1O50_04385	COG2814	Major facilitator Superfamily
L1O50_04395	COG1278	Cold shock
L1O50_04400	COG0564	pseudouridine synthase activity
L1O50_04415	COG2309	aminopeptidase activity
L1O50_04470	COG2801	Transposase and inactivated derivatives
L1O50_04500	COG0024	Methionine aminopeptidase
L1O50_04525	COG0562	UDP-galactopyranose mutase
L1O50_04540	COG1705	Flagellar rod assembly protein muramidase FlgJ
L1O50_04550	COG0463	Glycosyl transferase, family 2
L1O50_04560	COG1216	Glycosyl transferase, family 2
L1O50_04590	COG1420	regulation of RNA biosynthetic process
L1O50_04600	COG0443	Heat shock 70 kDa protein
L1O50_04605	COG0484	heat shock protein binding
L1O50_04620	COG1234	tRNA 3'-trailer cleavage
L1O50_04625	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
L1O50_04625	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
L1O50_04645	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
L1O50_04650	COG4224	UPF0291 protein
L1O50_04655	COG3763	UPF0154 protein
L1O50_04670	COG0791	NLP P60 protein
L1O50_04670	COG3883	PFAM NLP P60 protein
L1O50_04675	COG0204	Acyl-transferase
L1O50_04680	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
L1O50_04685	COG2827	Endonuclease containing a URI domain
L1O50_04690	COG0052	Belongs to the universal ribosomal protein uS2 family
L1O50_04695	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
L1O50_04705	COG0233	cytoplasmic translational termination
L1O50_04720	COG0489	protein tyrosine kinase activity
L1O50_04725	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
L1O50_04730	COG0438	transferase activity, transferring glycosyl groups
L1O50_04740	COG1216	Glycosyl transferase, family 2
L1O50_04755	COG1216	Glycosyl transferase, family 2
L1O50_04760	COG1316	TRANSCRIPTIONal
L1O50_04765	COG5263	repeat protein
L1O50_04765	COG0366	Alpha amylase catalytic
L1O50_04775	COG0004	ammonium transporteR
L1O50_04780	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
L1O50_04785	COG1266	CAAX protease self-immunity
L1O50_04795	COG0617	tRNA 3'-terminal CCA addition
L1O50_04800	COG0488	(ABC) transporter
L1O50_04805	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
L1O50_04815	COG0587	DNA-directed DNA polymerase activity
L1O50_04820	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
L1O50_04825	COG1490	D-aminoacyl-tRNA deacylase activity
L1O50_04835	COG0475	glutathione-regulated potassium exporter activity
L1O50_04845	COG2996	Protein conserved in bacteria
L1O50_04860	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
L1O50_04865	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
L1O50_04870	COG1187	pseudouridine synthase activity
L1O50_04885	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
L1O50_04895	COG0514	ATP-dependent DNA helicase (RecQ)
L1O50_04905	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
L1O50_04910	COG0539	negative regulation of cytoplasmic translation
L1O50_04915	COG1160	GTP binding
L1O50_04925	COG0351	phosphomethylpyrimidine kinase
L1O50_04930	COG4720	Psort location CytoplasmicMembrane, score
L1O50_04935	COG2807	transmembrane transport
L1O50_04945	COG0420	3'-5' exonuclease activity
L1O50_04950	COG0419	ATPase involved in DNA repair
L1O50_04995	COG0457	Tetratricopeptide repeat
L1O50_05000	COG0071	Belongs to the small heat shock protein (HSP20) family
L1O50_05005	COG2384	SAM-dependent methyltransferase
L1O50_05010	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
L1O50_05040	COG0267	Belongs to the bacterial ribosomal protein bL33 family
L1O50_05045	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
L1O50_05055	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
L1O50_05065	COG0577	efflux transmembrane transporter activity
L1O50_05070	COG1136	(ABC) transporter
L1O50_05085	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
L1O50_05095	COG0281	malic enzyme
L1O50_05100	COG0583	DNA-binding transcription factor activity
L1O50_05105	COG4221	oxidoreductase activity
L1O50_05110	COG0531	amino acid
L1O50_05120	COG4708	membrane
L1O50_05125	COG1028	Short-chain dehydrogenase reductase Sdr
L1O50_05155	COG0481	GTPase activity
L1O50_05165	COG0531	amino acid
L1O50_05185	COG2723	6-phospho-beta-galactosidase activity
L1O50_05195	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
L1O50_05205	COG0306	phosphate transporter
L1O50_05215	COG1609	Transcriptional regulator
L1O50_05225	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
L1O50_05225	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
L1O50_05225	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
L1O50_05230	COG1105	Belongs to the carbohydrate kinase PfkB family
L1O50_05235	COG1349	DNA-binding transcription factor activity
L1O50_05240	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
L1O50_05245	COG0446	pyridine nucleotide-disulphide oxidoreductase
L1O50_05275	COG1397	ADP-ribosylglycohydrolase
L1O50_05280	COG1719	4-vinyl reductase, 4VR
L1O50_05285	COG0220	tRNA (guanine-N7-)-methyltransferase activity
L1O50_05295	COG1131	(ABC) transporter
L1O50_05300	COG0537	adenosine 5'-monophosphoramidase activity
L1O50_05310	COG0363	glucosamine-6-phosphate deaminase activity
L1O50_05315	COG3104	oligopeptide transport
L1O50_05325	COG0439	Biotin carboxylase
L1O50_05335	COG0556	nucleotide-excision repair
L1O50_05355	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
L1O50_05365	COG0116	Belongs to the methyltransferase superfamily
L1O50_05375	COG3599	regulation of cell shape
L1O50_05380	COG4474	Belongs to the UPF0398 family
L1O50_05385	COG3331	DNA recombination
L1O50_05395	COG3935	DnaD domain protein
L1O50_05400	COG0017	Asparaginyl-tRNA synthetase
L1O50_05410	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
L1O50_05410	COG1199	ATP-dependent helicase activity
L1O50_05430	COG1304	FMN binding
L1O50_05440	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
L1O50_05445	COG1028	Short-chain dehydrogenase reductase Sdr
L1O50_05450	COG0706	membrane insertase activity
L1O50_05475	COG1705	Flagellar rod assembly protein muramidase FlgJ
L1O50_05475	COG3942	CHAP domain
L1O50_05485	COG5002	protein histidine kinase activity
L1O50_05490	COG0745	RESPONSE REGULATOR receiver
L1O50_05505	COG1484	DNA-dependent DNA replication
L1O50_05515	COG0237	dephospho-CoA kinase activity
L1O50_05520	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
L1O50_05525	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
L1O50_05525	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
L1O50_05530	COG0670	Belongs to the BI1 family
L1O50_05535	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
L1O50_05545	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L1O50_05550	COG1363	Peptidase, m42
L1O50_05555	COG0572	uridine kinase
L1O50_05560	COG5002	protein histidine kinase activity
L1O50_05565	COG0745	RESPONSE REGULATOR receiver
L1O50_05595	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
L1O50_05600	COG0358	DNA primase activity
L1O50_05605	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
L1O50_05610	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
L1O50_05620	COG0477	Major facilitator Superfamily
L1O50_05625	COG3480	Lon protease (S16) C-terminal proteolytic domain
L1O50_05630	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
L1O50_05635	COG0742	ribosomal rna small subunit methyltransferase
L1O50_05640	COG4471	UPF0298 protein
L1O50_05645	COG0772	Belongs to the SEDS family
L1O50_05650	COG1217	gtp-binding protein TYPA
L1O50_05655	COG0483	inositol monophosphate 1-phosphatase activity
L1O50_05660	COG4476	Belongs to the UPF0223 family
L1O50_05665	COG0242	peptide deformylase activity
L1O50_05680	COG5503	Protein of unknown function (DUF1447)
L1O50_05700	COG1011	Hydrolase
L1O50_05705	COG1597	lipid kinase activity
L1O50_05710	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
L1O50_05715	COG1464	Belongs to the NlpA lipoprotein family
L1O50_05720	COG0446	pyridine nucleotide-disulphide oxidoreductase
L1O50_05735	COG4175	Glycine betaine
L1O50_05735	COG3448	diguanylate cyclase activity
L1O50_05755	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
L1O50_05765	COG4974	Belongs to the 'phage' integrase family
L1O50_05770	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
L1O50_05775	COG0758	DNA mediated transformation
L1O50_05780	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
L1O50_05790	COG4479	Belongs to the UPF0346 family
L1O50_05800	COG2755	lipolytic protein G-D-S-L family
L1O50_05805	COG1307	EDD domain protein, DegV family
L1O50_05810	COG1307	EDD domain protein, DegV family
L1O50_05815	COG2270	Major facilitator Superfamily
L1O50_05830	COG3142	Participates in the control of copper homeostasis
L1O50_05835	COG1293	RNA-binding protein homologous to eukaryotic snRNP
L1O50_05840	COG0196	riboflavin kinase activity
L1O50_05850	COG1252	NADH dehydrogenase
L1O50_05855	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
L1O50_05860	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
L1O50_05865	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
L1O50_05875	COG2740	Nucleic-acid-binding protein implicated in transcription termination
L1O50_05880	COG0195	Participates in both transcription termination and antitermination
L1O50_05885	COG0779	Required for maturation of 30S ribosomal subunits
L1O50_05900	COG1304	FMN binding
L1O50_05930	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
L1O50_05935	COG0738	Major facilitator superfamily
L1O50_05945	COG0287	Prephenate dehydrogenase
L1O50_05950	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
L1O50_05955	COG4684	Psort location CytoplasmicMembrane, score
L1O50_05960	COG1621	beta-fructofuranosidase activity
L1O50_05970	COG0384	phenazine biosynthesis protein PhzF
L1O50_06025	COG1846	Transcriptional regulator
L1O50_06035	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
L1O50_06040	COG0656	L-ascorbic acid biosynthetic process
L1O50_06050	COG0583	DNA-binding transcription factor activity
L1O50_06085	COG0488	(ABC) transporter
L1O50_06090	COG0488	(ABC) transporter
L1O50_06105	COG2814	Major facilitator Superfamily
L1O50_06110	COG2239	Acts as a magnesium transporter
L1O50_06115	COG0564	pseudouridine synthase activity
L1O50_06120	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
L1O50_06125	COG2357	RelA SpoT domain protein
L1O50_06140	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
L1O50_06145	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
L1O50_06230	COG1940	carbohydrate kinase activity
L1O50_06240	COG1028	Short-chain dehydrogenase reductase Sdr
L1O50_06260	COG0352	thiamine-phosphate diphosphorylase activity
L1O50_06265	COG0351	phosphomethylpyrimidine kinase
L1O50_06270	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
L1O50_06285	COG1464	Belongs to the NlpA lipoprotein family
L1O50_06300	COG0436	Aminotransferase
L1O50_06305	COG0277	FAD linked oxidase domain protein
L1O50_06335	COG2801	Transposase and inactivated derivatives
L1O50_06380	COG2801	Transposase and inactivated derivatives
L1O50_06400	COG0604	alcohol dehydrogenase
L1O50_06400	COG3321	synthase
L1O50_06405	COG0248	Ppx GppA phosphatase
L1O50_06410	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
L1O50_06455	COG3201	nicotinamide mononucleotide transporter
L1O50_06460	COG1434	Gram-negative-bacterium-type cell wall biogenesis
L1O50_06480	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
L1O50_06495	COG1473	amidohydrolase
L1O50_06505	COG3527	Alpha-acetolactate decarboxylase
L1O50_06510	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
L1O50_06515	COG0187	DNA topoisomerase II activity
L1O50_06520	COG3118	belongs to the thioredoxin family
L1O50_06540	COG1193	negative regulation of DNA recombination
L1O50_06560	COG0218	Necessary for normal cell division and for the maintenance of normal septation
L1O50_06565	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
L1O50_06570	COG0544	peptidyl-prolyl cis-trans isomerase activity
L1O50_06595	COG0268	Binds directly to 16S ribosomal RNA
L1O50_06600	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
L1O50_06605	COG1466	dna polymerase III delta subunit
L1O50_06610	COG2333	competence protein COMEC
L1O50_06610	COG0658	competence protein
L1O50_06620	COG3906	Belongs to the UPF0473 family
L1O50_06640	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
L1O50_06645	COG1929	Belongs to the glycerate kinase type-1 family
L1O50_06655	COG0513	Belongs to the DEAD box helicase family
L1O50_06660	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
L1O50_06665	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
L1O50_06670	COG1862	Preprotein translocase
L1O50_06675	COG0343	queuine tRNA-ribosyltransferase activity
L1O50_06710	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
L1O50_06715	COG2255	four-way junction helicase activity
L1O50_06720	COG0632	four-way junction helicase activity
L1O50_06725	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
L1O50_06730	COG0516	GMP reductase activity
L1O50_06730	COG0517	IMP dehydrogenase activity
L1O50_06735	COG0517	IMP dehydrogenase activity
L1O50_06735	COG0516	GMP reductase activity
L1O50_06750	COG1739	Uncharacterized protein family UPF0029
L1O50_06755	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
L1O50_06760	COG0322	excinuclease ABC activity
L1O50_06770	COG1668	transmembrane transport
L1O50_06775	COG4152	abc transporter atp-binding protein
L1O50_06785	COG1674	ftsk spoiiie
L1O50_06795	COG0628	permease
L1O50_06800	COG2706	6-phosphogluconolactonase activity
L1O50_06820	COG0751	glycine-tRNA ligase activity
L1O50_06825	COG0752	glycyl-tRNA synthetase alpha subunit
L1O50_06840	COG1381	Involved in DNA repair and RecF pathway recombination
L1O50_06845	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
L1O50_06850	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
L1O50_06855	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
L1O50_06860	COG1702	phosphate starvation-inducible protein PhoH
L1O50_06865	COG1610	YqeY-like protein
L1O50_06870	COG0828	Belongs to the bacterial ribosomal protein bS21 family
L1O50_06875	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
L1O50_06885	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
L1O50_06890	COG0124	histidyl-tRNA synthetase
L1O50_06895	COG0860	N-Acetylmuramoyl-L-alanine amidase
L1O50_06910	COG3425	synthase
L1O50_06915	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
L1O50_06985	COG0006	proline dipeptidase activity
L1O50_06990	COG1609	Transcriptional regulator
L1O50_07005	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
L1O50_07010	COG1164	Oligoendopeptidase f
L1O50_07020	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
L1O50_07025	COG2723	6-phospho-beta-galactosidase activity
L1O50_07030	COG1447	Phosphotransferase system cellobiose-specific component IIA
L1O50_07035	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
L1O50_07040	COG2723	6-phospho-beta-galactosidase activity
L1O50_07045	COG4862	establishment of competence for transformation
L1O50_07050	COG1393	Belongs to the ArsC family
L1O50_07055	COG3853	Toxic anion resistance protein (TelA)
L1O50_07120	COG0561	phosphatase activity
L1O50_07125	COG1970	mechanosensitive ion channel activity
L1O50_07130	COG1428	Deoxynucleoside kinase
L1O50_07140	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
L1O50_07145	COG1942	4-Oxalocrotonate Tautomerase
L1O50_07150	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
L1O50_07160	COG0335	large ribosomal subunit rRNA binding
L1O50_07165	COG0336	Belongs to the RNA methyltransferase TrmD family
L1O50_07170	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
L1O50_07175	COG0588	phosphoglycerate mutase activity
L1O50_07190	COG0228	four-way junction DNA binding
L1O50_07210	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
L1O50_07215	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
L1O50_07220	COG0552	protein localization to endoplasmic reticulum
L1O50_07225	COG1196	nuclear chromosome segregation
L1O50_07230	COG0571	ribonuclease III activity
L1O50_07235	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
L1O50_07240	COG0416	fatty acid biosynthetic process
L1O50_07245	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
L1O50_07255	COG0438	transferase activity, transferring glycosyl groups
L1O50_07270	COG1461	Dihydroxyacetone kinase
L1O50_07280	COG0227	Belongs to the bacterial ribosomal protein bL28 family
L1O50_07290	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
L1O50_07295	COG1162	GTPase activity
L1O50_07300	COG2815	serine threonine protein kinase
L1O50_07300	COG0515	serine threonine protein kinase
L1O50_07305	COG0631	protein serine/threonine phosphatase activity
L1O50_07310	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
L1O50_07310	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
L1O50_07315	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
L1O50_07320	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
L1O50_07325	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
L1O50_07360	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
L1O50_07365	COG2252	PERMEase
L1O50_07370	COG0217	transcriptional regulatory protein
L1O50_07375	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
L1O50_07395	COG3599	regulation of cell shape
L1O50_07410	COG1799	cell septum assembly
L1O50_07420	COG0849	cell division
L1O50_07425	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
L1O50_07430	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
L1O50_07435	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
L1O50_07440	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
L1O50_07445	COG0768	penicillin binding
L1O50_07455	COG0275	rRNA processing
L1O50_07460	COG2001	Belongs to the MraZ family
L1O50_07470	COG1385	rRNA (uridine-N3-)-methyltransferase activity
L1O50_07475	COG2264	protein methyltransferase activity
L1O50_07485	COG0833	amino acid
L1O50_07500	COG0446	pyridine nucleotide-disulphide oxidoreductase
L1O50_07515	COG2759	Belongs to the formate--tetrahydrofolate ligase family
L1O50_07520	COG0151	Belongs to the GarS family
L1O50_07525	COG0138	bifunctional purine biosynthesis protein purh
L1O50_07530	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
L1O50_07535	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
L1O50_07545	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
L1O50_07560	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
L1O50_07565	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
L1O50_07570	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
L1O50_07575	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
L1O50_07575	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
L1O50_07580	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L1O50_07585	COG1126	abc transporter atp-binding protein
L1O50_07590	COG0765	amino acid transport
L1O50_07600	COG3338	carbonate dehydratase activity
L1O50_07610	COG1077	Cell shape determining protein MreB Mrl
L1O50_07615	COG2003	Belongs to the UPF0758 family
L1O50_07630	COG1263	PTS System
L1O50_07630	COG2190	(PTS) system
L1O50_07630	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
L1O50_07635	COG1307	EDD domain protein, DegV family
L1O50_07640	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
L1O50_07645	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
L1O50_07650	COG0038	chloride channel
L1O50_07660	COG4120	Belongs to the binding-protein-dependent transport system permease family
L1O50_07670	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
L1O50_07675	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
L1O50_07680	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
L1O50_07700	COG0741	lytic transglycosylase activity
L1O50_07710	COG0400	carboxylic ester hydrolase activity
L1O50_07715	COG0346	lactoylglutathione lyase activity
L1O50_07720	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
L1O50_07730	COG0494	nUDIX hydrolase
L1O50_07735	COG1278	Cold shock
L1O50_07750	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
L1O50_07755	COG1388	LysM domain
L1O50_07755	COG1705	Flagellar rod assembly protein muramidase FlgJ
L1O50_07760	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
L1O50_07765	COG4988	ABC transporter
L1O50_07770	COG1294	oxidase, subunit
L1O50_07775	COG1271	oxidase subunit
L1O50_07780	COG4684	Psort location CytoplasmicMembrane, score
L1O50_07895	COG1098	S1 RNA binding domain
L1O50_07900	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
L1O50_07905	COG0586	Pfam SNARE associated Golgi protein
L1O50_07915	COG0194	GDP metabolic process
L1O50_07925	COG0497	DNA recombination
L1O50_07930	COG1438	arginine binding
L1O50_07935	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
L1O50_07940	COG0142	geranyltranstransferase activity
L1O50_07950	COG1570	exodeoxyribonuclease VII activity
L1O50_07955	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
L1O50_07960	COG4720	Psort location CytoplasmicMembrane, score
L1O50_07975	COG1136	(ABC) transporter
L1O50_07980	COG0577	efflux transmembrane transporter activity
L1O50_07990	COG0776	regulation of translation
L1O50_07995	COG0363	glucosamine-6-phosphate deaminase activity
L1O50_08005	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
L1O50_08100	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
L1O50_08105	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
L1O50_08115	COG1323	Belongs to the UPF0348 family
L1O50_08120	COG2226	methyltransferase
L1O50_08125	COG0799	negative regulation of ribosome biogenesis
L1O50_08130	COG1713	HD superfamily hydrolase involved in NAD metabolism
L1O50_08135	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
L1O50_08145	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
L1O50_08150	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
L1O50_08155	COG1181	Belongs to the D-alanine--D-alanine ligase family
L1O50_08165	COG0531	amino acid
L1O50_08170	COG0459	protein refolding
L1O50_08175	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
L1O50_08180	COG0488	(ABC) transporter
L1O50_08200	COG0285	dihydrofolate synthase activity
L1O50_08210	COG0525	valine-tRNA ligase activity
L1O50_08245	COG1272	protein, Hemolysin III
L1O50_08355	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
L1O50_08365	COG5506	Protein of unknown function (DUF1694)
L1O50_08375	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
L1O50_08400	COG2137	regulation of response to DNA damage stimulus
L1O50_08405	COG0704	Plays a role in the regulation of phosphate uptake
L1O50_08410	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
L1O50_08415	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
L1O50_08420	COG0581	inorganic phosphate transmembrane transporter activity
L1O50_08425	COG0573	inorganic phosphate transmembrane transporter activity
L1O50_08450	COG0673	inositol 2-dehydrogenase activity
L1O50_08455	COG4166	transmembrane transport
L1O50_08460	COG0647	UMP catabolic process
L1O50_08465	COG4470	Protein conserved in bacteria
L1O50_08470	COG0737	Belongs to the 5'-nucleotidase family
L1O50_08490	COG4948	Mandelate Racemase Muconate Lactonizing
L1O50_08495	COG0596	Alpha beta hydrolase
L1O50_08500	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
L1O50_08505	COG1169	isochorismate synthase
L1O50_08510	COG0778	Nitroreductase
L1O50_08515	COG1132	(ABC) transporter
L1O50_08525	COG1472	Belongs to the glycosyl hydrolase 3 family
L1O50_08530	COG0211	Belongs to the bacterial ribosomal protein bL27 family
L1O50_08535	COG0261	This protein binds to 23S rRNA in the presence of protein L20
L1O50_08560	COG0174	glutamine synthetase
L1O50_08565	COG0789	Transcriptional regulator
L1O50_08570	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
L1O50_08575	COG0584	glycerophosphoryl diester phosphodiesterase
L1O50_08595	COG3942	CHAP domain
L1O50_08610	COG1940	carbohydrate kinase activity
L1O50_08625	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
L1O50_08630	COG0768	penicillin binding
L1O50_08640	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
L1O50_08645	COG0514	ATP-dependent DNA helicase (RecQ)
L1O50_08650	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
L1O50_08655	COG0072	phenylalanine-tRNA ligase activity
L1O50_08655	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L1O50_08660	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
L1O50_08665	COG1733	regulation of RNA biosynthetic process
L1O50_08675	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
L1O50_08695	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
L1O50_08700	COG0653	protein targeting
L1O50_08710	COG4956	integral membrane protein (PIN domain superfamily)
L1O50_08720	COG0756	dUTP diphosphatase activity
L1O50_08730	COG0791	NLP P60 protein
L1O50_08735	COG1388	LysM domain
L1O50_08735	COG3942	CHAP domain
L1O50_08745	COG3527	Alpha-acetolactate decarboxylase
L1O50_08750	COG0028	Belongs to the TPP enzyme family
L1O50_08755	COG0039	L-malate dehydrogenase activity
L1O50_08775	COG1914	H( )-stimulated, divalent metal cation uptake system
L1O50_08785	COG1263	PTS System
L1O50_08785	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
L1O50_08800	COG0740	serine-type endopeptidase activity
L1O50_08805	COG1481	regulation of sporulation
L1O50_08810	COG0391	Required for morphogenesis under gluconeogenic growth conditions
L1O50_08825	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
L1O50_08830	COG2814	Major facilitator Superfamily
L1O50_08840	COG0671	phosphoesterase, PA-phosphatase related
L1O50_08855	COG0366	Alpha amylase catalytic
L1O50_08870	COG1573	uracil-dna glycosylase
L1O50_08885	COG0028	Belongs to the TPP enzyme family
L1O50_08905	COG4221	oxidoreductase activity
L1O50_08915	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
L1O50_08920	COG0101	tRNA pseudouridine synthase activity
L1O50_08930	COG1122	ATPase activity
L1O50_08935	COG1122	ATPase activity
L1O50_08945	COG1252	NADH dehydrogenase
L1O50_08950	COG0803	Belongs to the bacterial solute-binding protein 9 family
L1O50_08955	COG1108	ABC-type Mn2 Zn2 transport systems permease components
L1O50_08960	COG1121	(ABC) transporter
L1O50_08970	COG0222	ribosome binding
L1O50_08975	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
L1O50_08980	COG0081	regulation of translation
L1O50_08985	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
L1O50_08990	COG0250	Participates in transcription elongation, termination and antitermination
L1O50_08995	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
L1O50_09010	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
L1O50_09015	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
L1O50_09020	COG1854	S-ribosylhomocysteine lyase activity
L1O50_09025	COG1464	Belongs to the NlpA lipoprotein family
L1O50_09030	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
L1O50_09035	COG0626	cystathionine gamma-synthase activity
L1O50_09040	COG0215	cysteine-tRNA ligase activity
L1O50_09045	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
L1O50_09050	COG0039	L-malate dehydrogenase activity
L1O50_09055	COG0471	metal ion transport
L1O50_09060	COG1053	succinate dehydrogenase
L1O50_09065	COG0114	fumarate hydratase activity
L1O50_09070	COG0583	DNA-binding transcription factor activity
L1O50_09095	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
L1O50_09110	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
L1O50_09135	COG0203	ribosomal protein L17
L1O50_09140	COG0202	RNA polymerase activity
L1O50_09145	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
L1O50_09150	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
L1O50_09155	COG0257	Belongs to the bacterial ribosomal protein bL36 family
L1O50_09160	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
L1O50_09175	COG0200	Binds to the 23S rRNA
L1O50_09180	COG1841	ribosomal large subunit assembly
L1O50_09185	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
L1O50_09190	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
L1O50_09195	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
L1O50_09200	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
L1O50_09205	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
L1O50_09210	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
L1O50_09215	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
L1O50_09225	COG0255	Belongs to the universal ribosomal protein uL29 family
L1O50_09230	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
L1O50_09235	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
L1O50_09240	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
L1O50_09245	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
L1O50_09250	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
L1O50_09255	COG0089	rRNA binding
L1O50_09265	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
L1O50_09270	COG0051	transcription antitermination factor activity, RNA binding
L1O50_09275	COG0142	geranyltranstransferase activity
L1O50_09280	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
L1O50_09290	COG0456	acetyltransferase
L1O50_09295	COG1214	PFAM Peptidase M22, glycoprotease
L1O50_09300	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
L1O50_09320	COG3870	Protein conserved in bacteria
L1O50_09325	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
L1O50_09350	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
L1O50_09360	COG0590	tRNA wobble adenosine to inosine editing
L1O50_09365	COG2813	Specifically methylates the guanine in position
L1O50_09375	COG2807	transmembrane transport
L1O50_09385	COG3620	sequence-specific DNA binding
L1O50_09430	COG0500	methyltransferase
L1O50_09435	COG1309	transcriptional regulator
L1O50_09455	COG1979	alcohol dehydrogenase
L1O50_09470	COG0085	RNA polymerase activity
L1O50_09475	COG0542	response to heat
L1O50_09480	COG4463	regulation of RNA biosynthetic process
L1O50_09505	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
L1O50_09510	COG1428	Deoxynucleoside kinase
L1O50_09515	COG1876	peptidase activity
L1O50_09520	COG0355	proton-transporting ATP synthase activity, rotational mechanism
L1O50_09525	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
L1O50_09530	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
L1O50_09535	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
L1O50_09540	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
L1O50_09545	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
L1O50_09550	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
L1O50_09555	COG0356	it plays a direct role in the translocation of protons across the membrane
L1O50_09560	COG2233	PERMEase
L1O50_09570	COG0702	epimerase
L1O50_09575	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
L1O50_09580	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
L1O50_09585	COG0009	L-threonylcarbamoyladenylate synthase
L1O50_09590	COG2890	protein-(glutamine-N5) methyltransferase activity
L1O50_09595	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
L1O50_09600	COG1435	thymidine kinase activity
L1O50_09610	COG3442	glutamine amidotransferase
L1O50_09615	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
L1O50_09620	COG1482	cell wall glycoprotein biosynthetic process
L1O50_09630	COG0110	maltose O-acetyltransferase activity
L1O50_09655	COG1132	(ABC) transporter
L1O50_09660	COG1132	(ABC) transporter
L1O50_09675	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
L1O50_09680	COG0588	phosphoglycerate mutase activity
L1O50_09700	COG0708	Exodeoxyribonuclease III
L1O50_09710	COG1012	belongs to the aldehyde dehydrogenase family
L1O50_09710	COG1454	alcohol dehydrogenase
L1O50_09715	COG3590	peptidase
L1O50_09755	COG5039	Polysaccharide pyruvyl transferase
L1O50_09770	COG2801	Transposase and inactivated derivatives
L1O50_09775	COG1215	transferase activity, transferring glycosyl groups
L1O50_09780	COG1216	Glycosyl transferase, family 2
L1O50_09780	COG1442	glycosyl transferase family 8
L1O50_09800	COG0463	Glycosyl transferase, family 2
L1O50_09800	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
L1O50_09815	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
L1O50_09820	COG2188	Transcriptional regulator
L1O50_09825	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
L1O50_09830	COG2814	Major facilitator Superfamily
L1O50_09835	COG1418	mRNA catabolic process
L1O50_09850	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
L1O50_09855	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
L1O50_09860	COG1215	transferase activity, transferring glycosyl groups
L1O50_09900	COG0765	amino acid transport
L1O50_09935	COG0656	L-ascorbic acid biosynthetic process
L1O50_09940	COG2160	L-arabinose isomerase activity
L1O50_09965	COG3940	Belongs to the glycosyl hydrolase 43 family
L1O50_09980	COG0534	Mate efflux family protein
L1O50_09985	COG0488	(ABC) transporter
L1O50_09990	COG1373	ATPase (AAA superfamily
L1O50_09995	COG1108	ABC-type Mn2 Zn2 transport systems permease components
L1O50_10000	COG1121	(ABC) transporter
L1O50_10010	COG1846	Transcriptional regulator
L1O50_10025	COG2755	lipolytic protein G-D-S-L family
L1O50_10025	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
L1O50_10030	COG3091	SprT-like family
L1O50_10075	COG4975	Glucose uptake
L1O50_10080	COG0477	Major facilitator Superfamily
L1O50_10085	COG3104	oligopeptide transport
L1O50_10135	COG1686	Belongs to the peptidase S11 family
L1O50_10145	COG0745	RESPONSE REGULATOR receiver
L1O50_10155	COG0012	GTP binding
L1O50_10160	COG4481	Protein conserved in bacteria
L1O50_10165	COG1475	DNA binding
L1O50_10170	COG1192	Involved in chromosome partitioning
L1O50_10175	COG0357	Ribosomal RNA small subunit methyltransferase G
L1O50_10185	COG1194	a g-specific adenine glycosylase
L1O50_10190	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
L1O50_10230	COG5002	protein histidine kinase activity
L1O50_10235	COG0745	RESPONSE REGULATOR receiver
L1O50_10250	COG0318	PFAM AMP-dependent synthetase and ligase
L1O50_10255	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
L1O50_10260	COG2050	protein possibly involved in aromatic compounds catabolism
L1O50_10265	COG1335	isochorismatase
L1O50_10270	COG2226	methyltransferase
L1O50_10280	COG4443	Transcriptional Coactivator p15 (PC4)
L1O50_10285	COG0252	asparaginase activity
L1O50_10290	COG0531	amino acid
L1O50_10295	COG1113	amino acid transport
L1O50_10300	COG0531	amino acid
L1O50_10310	COG4975	Glucose uptake
L1O50_10315	COG0477	Major facilitator Superfamily
L1O50_10330	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
L1O50_10340	COG2267	carboxylic ester hydrolase activity
L1O50_10345	COG4166	transmembrane transport
L1O50_10350	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
L1O50_10360	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
L1O50_10370	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
L1O50_10380	COG3223	Belongs to the PsiE family
L1O50_10390	COG0531	amino acid
L1O50_10395	COG1228	amidohydrolase
L1O50_10410	COG2070	2-Nitropropane dioxygenase
L1O50_10420	COG0583	DNA-binding transcription factor activity
L1O50_10425	COG2855	membrane
L1O50_10435	COG3620	sequence-specific DNA binding
L1O50_10440	COG2855	membrane
L1O50_10455	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
L1O50_10480	COG1113	amino acid transport
L1O50_10510	COG0628	permease
L1O50_10520	COG0392	lysyltransferase activity
L1O50_10520	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
L1O50_10530	COG1254	Belongs to the acylphosphatase family
L1O50_10535	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L1O50_10540	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L1O50_10545	COG0765	amino acid transport
L1O50_10550	COG1126	abc transporter atp-binding protein
L1O50_10560	COG1131	(ABC) transporter
L1O50_10570	COG0390	transport system, permease component
L1O50_10575	COG4619	ABC transporter
L1O50_10585	COG0656	L-ascorbic acid biosynthetic process
L1O50_10595	COG1132	(ABC) transporter
L1O50_10600	COG1846	Transcriptional regulator
L1O50_10620	COG1744	ABC transporter substrate-binding protein PnrA-like
L1O50_10625	COG0697	spore germination
L1O50_10635	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
L1O50_10650	COG0789	Transcriptional regulator
L1O50_10665	COG1131	(ABC) transporter
L1O50_10690	COG0505	Belongs to the CarA family
L1O50_10695	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
L1O50_10700	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
L1O50_10710	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
L1O50_10715	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
L1O50_10720	COG0165	Argininosuccinate lyase
L1O50_10725	COG0137	argininosuccinate synthase activity
L1O50_10730	COG1744	ABC transporter substrate-binding protein PnrA-like
L1O50_10745	COG0697	spore germination
L1O50_10765	COG2723	6-phospho-beta-galactosidase activity
L1O50_10770	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
L1O50_10770	COG0517	IMP dehydrogenase activity
L1O50_10795	COG1476	TRANSCRIPTIONal
L1O50_10860	COG1881	PFAM PEBP family protein
L1O50_10900	COG2252	PERMEase
L1O50_10905	COG3152	Membrane
L1O50_10925	COG0328	RNA-DNA hybrid ribonuclease activity
L1O50_10935	COG0561	phosphatase activity
L1O50_10940	COG1033	growth of symbiont in host cell
L1O50_10940	COG2409	Drug exporters of the RND superfamily
L1O50_10945	COG0577	efflux transmembrane transporter activity
L1O50_10950	COG1136	(ABC) transporter
L1O50_10960	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
L1O50_10965	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
L1O50_10975	COG0446	pyridine nucleotide-disulphide oxidoreductase
L1O50_10985	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
L1O50_11005	COG1113	amino acid transport
L1O50_11010	COG0569	domain protein
L1O50_11025	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
L1O50_11035	COG1120	ATPase activity
L1O50_11045	COG0706	membrane insertase activity
L1O50_11050	COG0594	ribonuclease P activity
L1O50_11055	COG0230	Belongs to the bacterial ribosomal protein bL34 family
L1O50_11090	COG0783	Belongs to the Dps family
L1O50_11095	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
L1O50_11115	COG1250	3-hydroxyacyl-CoA dehydrogenase
L1O50_11120	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
L1O50_11130	COG2801	Transposase and inactivated derivatives
L1O50_11135	COG2910	NAD(P)H-binding
L1O50_11140	COG1733	regulation of RNA biosynthetic process
L1O50_11145	COG2801	Transposase and inactivated derivatives
L1O50_11160	COG1573	uracil-dna glycosylase
L1O50_11165	COG2801	Transposase and inactivated derivatives