locus-tag	class	description
HUW87_00010	COG4989	oxidoreductase activity
HUW87_00015	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HUW87_00020	COG2233	PERMEase
HUW87_00035	COG1028	Short-chain dehydrogenase reductase Sdr
HUW87_00045	COG1620	l-lactate permease
HUW87_00050	COG4989	oxidoreductase activity
HUW87_00055	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HUW87_00060	COG2233	PERMEase
HUW87_00075	COG1028	Short-chain dehydrogenase reductase Sdr
HUW87_00085	COG1620	l-lactate permease
HUW87_00090	COG4989	oxidoreductase activity
HUW87_00125	COG1132	(ABC) transporter
HUW87_00130	COG1132	(ABC) transporter
HUW87_00135	COG0747	negative chemotaxis
HUW87_00140	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HUW87_00145	COG0601	transmembrane transport
HUW87_00150	COG4608	Belongs to the ABC transporter superfamily
HUW87_00155	COG0444	Belongs to the ABC transporter superfamily
HUW87_00160	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
HUW87_00165	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HUW87_00170	COG2190	(PTS) system
HUW87_00170	COG2211	Major facilitator Superfamily
HUW87_00190	COG0436	Aminotransferase
HUW87_00200	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HUW87_00205	COG2723	6-phospho-beta-galactosidase activity
HUW87_00210	COG2723	6-phospho-beta-galactosidase activity
HUW87_00215	COG1447	Phosphotransferase system cellobiose-specific component IIA
HUW87_00220	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HUW87_00225	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HUW87_00240	COG1216	Glycosyl transferase, family 2
HUW87_00255	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HUW87_00310	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
HUW87_00315	COG1737	Transcriptional regulator
HUW87_00325	COG0656	L-ascorbic acid biosynthetic process
HUW87_00330	COG2261	transglycosylase associated protein
HUW87_00395	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HUW87_00400	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HUW87_00415	COG0037	tRNA processing
HUW87_00425	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HUW87_00430	COG2244	polysaccharide biosynthetic process
HUW87_00435	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HUW87_00440	COG0193	aminoacyl-tRNA hydrolase activity
HUW87_00450	COG0058	SHG alpha-glucan phosphorylase activity
HUW87_00455	COG0297	glycogen (starch) synthase activity
HUW87_00460	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HUW87_00470	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HUW87_00480	COG1511	domain protein
HUW87_00480	COG1511	domain protein
HUW87_00485	COG1309	transcriptional regulator
HUW87_00500	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HUW87_00505	COG0477	Major facilitator Superfamily
HUW87_00515	COG0667	Aldo Keto reductase
HUW87_00525	COG2115	Belongs to the xylose isomerase family
HUW87_00535	COG2211	Major facilitator Superfamily
HUW87_00540	COG3507	Belongs to the glycosyl hydrolase 43 family
HUW87_00565	COG2818	Glycosylase
HUW87_00570	COG1968	undecaprenyl-diphosphatase activity
HUW87_00585	COG1695	Transcriptional regulator
HUW87_00590	COG1983	PspC domain protein
HUW87_00595	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HUW87_00605	COG2801	Transposase and inactivated derivatives
HUW87_00610	COG0737	Belongs to the 5'-nucleotidase family
HUW87_00625	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
HUW87_00640	COG1263	PTS System
HUW87_00640	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HUW87_00645	COG1316	TRANSCRIPTIONal
HUW87_00655	COG2131	deaminase
HUW87_00660	COG4466	Protein conserved in bacteria
HUW87_00665	COG1253	flavin adenine dinucleotide binding
HUW87_00670	COG1253	flavin adenine dinucleotide binding
HUW87_00675	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HUW87_00680	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
HUW87_00685	COG0084	hydrolase, TatD family'
HUW87_00695	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HUW87_00695	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HUW87_00755	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HUW87_00775	COG1368	sulfuric ester hydrolase activity
HUW87_00780	COG2153	protein acetylation
HUW87_00795	COG0187	DNA topoisomerase II activity
HUW87_00800	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HUW87_00805	COG2501	S4 domain
HUW87_00810	COG0592	DNA-directed DNA polymerase activity
HUW87_00815	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HUW87_00820	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HUW87_00825	COG0594	ribonuclease P activity
HUW87_00830	COG0706	membrane insertase activity
HUW87_00840	COG1120	ATPase activity
HUW87_00850	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HUW87_00865	COG0569	domain protein
HUW87_00870	COG1113	amino acid transport
HUW87_00890	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HUW87_00900	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HUW87_00905	COG0446	pyridine nucleotide-disulphide oxidoreductase
HUW87_00915	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HUW87_00920	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HUW87_00930	COG1136	(ABC) transporter
HUW87_00935	COG0577	efflux transmembrane transporter activity
HUW87_00940	COG2409	Drug exporters of the RND superfamily
HUW87_00940	COG1033	growth of symbiont in host cell
HUW87_00945	COG0561	phosphatase activity
HUW87_00955	COG0328	RNA-DNA hybrid ribonuclease activity
HUW87_00975	COG3152	Membrane
HUW87_00980	COG2252	PERMEase
HUW87_01025	COG1881	PFAM PEBP family protein
HUW87_01050	COG1476	TRANSCRIPTIONal
HUW87_01080	COG0517	IMP dehydrogenase activity
HUW87_01080	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HUW87_01085	COG2723	6-phospho-beta-galactosidase activity
HUW87_01115	COG0697	spore germination
HUW87_01130	COG0561	phosphatase activity
HUW87_01135	COG0561	phosphatase activity
HUW87_01145	COG1744	ABC transporter substrate-binding protein PnrA-like
HUW87_01150	COG0137	argininosuccinate synthase activity
HUW87_01155	COG0165	Argininosuccinate lyase
HUW87_01165	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HUW87_01170	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HUW87_01175	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HUW87_01180	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HUW87_01185	COG0505	Belongs to the CarA family
HUW87_01210	COG1131	(ABC) transporter
HUW87_01220	COG0789	Transcriptional regulator
HUW87_01225	COG1028	Short-chain dehydrogenase reductase Sdr
HUW87_01235	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HUW87_01245	COG0697	spore germination
HUW87_01270	COG1846	Transcriptional regulator
HUW87_01275	COG1132	(ABC) transporter
HUW87_01285	COG0656	L-ascorbic acid biosynthetic process
HUW87_01295	COG4619	ABC transporter
HUW87_01300	COG0390	transport system, permease component
HUW87_01310	COG1131	(ABC) transporter
HUW87_01320	COG1126	abc transporter atp-binding protein
HUW87_01325	COG0765	amino acid transport
HUW87_01330	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HUW87_01335	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HUW87_01340	COG1254	Belongs to the acylphosphatase family
HUW87_01350	COG0392	lysyltransferase activity
HUW87_01350	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HUW87_01360	COG0628	permease
HUW87_01390	COG1113	amino acid transport
HUW87_01415	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HUW87_01420	COG0456	acetyltransferase
HUW87_01420	COG0454	-acetyltransferase
HUW87_01430	COG2855	membrane
HUW87_01440	COG2855	membrane
HUW87_01445	COG0583	DNA-binding transcription factor activity
HUW87_01455	COG2070	2-Nitropropane dioxygenase
HUW87_01470	COG1228	amidohydrolase
HUW87_01475	COG0531	amino acid
HUW87_01485	COG3223	Belongs to the PsiE family
HUW87_01495	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HUW87_01505	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HUW87_01515	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HUW87_01520	COG4166	transmembrane transport
HUW87_01525	COG2267	carboxylic ester hydrolase activity
HUW87_01535	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HUW87_01550	COG0477	Major facilitator Superfamily
HUW87_01555	COG4975	Glucose uptake
HUW87_01565	COG0531	amino acid
HUW87_01570	COG1113	amino acid transport
HUW87_01575	COG0531	amino acid
HUW87_01580	COG0252	asparaginase activity
HUW87_01585	COG4443	Transcriptional Coactivator p15 (PC4)
HUW87_01600	COG2226	methyltransferase
HUW87_01605	COG1335	isochorismatase
HUW87_01610	COG2050	protein possibly involved in aromatic compounds catabolism
HUW87_01615	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HUW87_01620	COG0318	PFAM AMP-dependent synthetase and ligase
HUW87_01635	COG0745	RESPONSE REGULATOR receiver
HUW87_01640	COG5002	protein histidine kinase activity
HUW87_01680	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HUW87_01685	COG1194	a g-specific adenine glycosylase
HUW87_01695	COG0357	Ribosomal RNA small subunit methyltransferase G
HUW87_01700	COG1192	Involved in chromosome partitioning
HUW87_01705	COG1475	DNA binding
HUW87_01710	COG4481	Protein conserved in bacteria
HUW87_01715	COG0012	GTP binding
HUW87_01725	COG0745	RESPONSE REGULATOR receiver
HUW87_01735	COG1686	Belongs to the peptidase S11 family
HUW87_01740	COG2801	Transposase and inactivated derivatives
HUW87_01795	COG3104	oligopeptide transport
HUW87_01800	COG0477	Major facilitator Superfamily
HUW87_01805	COG4975	Glucose uptake
HUW87_01850	COG3091	SprT-like family
HUW87_01855	COG2755	lipolytic protein G-D-S-L family
HUW87_01855	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HUW87_01860	COG1846	Transcriptional regulator
HUW87_01870	COG1121	(ABC) transporter
HUW87_01875	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HUW87_01880	COG1373	ATPase (AAA superfamily
HUW87_01885	COG0488	(ABC) transporter
HUW87_01890	COG0534	Mate efflux family protein
HUW87_01905	COG3940	Belongs to the glycosyl hydrolase 43 family
HUW87_01925	COG2160	L-arabinose isomerase activity
HUW87_01930	COG0656	L-ascorbic acid biosynthetic process
HUW87_01955	COG0765	amino acid transport
HUW87_01995	COG1215	transferase activity, transferring glycosyl groups
HUW87_02000	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
HUW87_02005	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HUW87_02020	COG1418	mRNA catabolic process
HUW87_02025	COG2814	Major facilitator Superfamily
HUW87_02030	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HUW87_02035	COG2188	Transcriptional regulator
HUW87_02040	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
HUW87_02055	COG1216	Glycosyl transferase, family 2
HUW87_02065	COG2801	Transposase and inactivated derivatives
HUW87_02075	COG5039	Polysaccharide pyruvyl transferase
HUW87_02120	COG3590	peptidase
HUW87_02130	COG1454	alcohol dehydrogenase
HUW87_02130	COG1012	belongs to the aldehyde dehydrogenase family
HUW87_02140	COG1373	ATPase (AAA superfamily
HUW87_02145	COG0708	Exodeoxyribonuclease III
HUW87_02165	COG0588	phosphoglycerate mutase activity
HUW87_02170	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HUW87_02185	COG1132	(ABC) transporter
HUW87_02190	COG1132	(ABC) transporter
HUW87_02195	COG1373	ATPase (AAA superfamily
HUW87_02235	COG1482	cell wall glycoprotein biosynthetic process
HUW87_02240	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HUW87_02245	COG3442	glutamine amidotransferase
HUW87_02255	COG1435	thymidine kinase activity
HUW87_02260	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HUW87_02265	COG2890	protein-(glutamine-N5) methyltransferase activity
HUW87_02270	COG0009	L-threonylcarbamoyladenylate synthase
HUW87_02275	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HUW87_02280	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HUW87_02285	COG0702	epimerase
HUW87_02295	COG2233	PERMEase
HUW87_02300	COG0356	it plays a direct role in the translocation of protons across the membrane
HUW87_02305	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HUW87_02310	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HUW87_02315	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HUW87_02320	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HUW87_02325	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HUW87_02330	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HUW87_02335	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HUW87_02340	COG1876	peptidase activity
HUW87_02345	COG1428	Deoxynucleoside kinase
HUW87_02350	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HUW87_02375	COG4463	regulation of RNA biosynthetic process
HUW87_02380	COG0542	response to heat
HUW87_02385	COG0085	RNA polymerase activity
HUW87_02405	COG1979	alcohol dehydrogenase
HUW87_02430	COG1309	transcriptional regulator
HUW87_02435	COG0500	methyltransferase
HUW87_02480	COG3620	sequence-specific DNA binding
HUW87_02490	COG2807	transmembrane transport
HUW87_02500	COG2813	Specifically methylates the guanine in position
HUW87_02505	COG0590	tRNA wobble adenosine to inosine editing
HUW87_02515	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HUW87_02540	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HUW87_02545	COG3870	Protein conserved in bacteria
HUW87_02565	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HUW87_02570	COG1214	PFAM Peptidase M22, glycoprotease
HUW87_02575	COG0456	acetyltransferase
HUW87_02585	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HUW87_02590	COG0142	geranyltranstransferase activity
HUW87_02595	COG0051	transcription antitermination factor activity, RNA binding
HUW87_02600	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HUW87_02610	COG0089	rRNA binding
HUW87_02615	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HUW87_02620	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HUW87_02625	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HUW87_02630	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HUW87_02635	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HUW87_02640	COG0255	Belongs to the universal ribosomal protein uL29 family
HUW87_02650	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HUW87_02655	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HUW87_02660	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HUW87_02665	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HUW87_02670	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HUW87_02675	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HUW87_02680	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HUW87_02685	COG1841	ribosomal large subunit assembly
HUW87_02690	COG0200	Binds to the 23S rRNA
HUW87_02705	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HUW87_02710	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HUW87_02715	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HUW87_02720	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HUW87_02725	COG0202	RNA polymerase activity
HUW87_02730	COG0203	ribosomal protein L17
HUW87_02755	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HUW87_02770	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HUW87_02795	COG0583	DNA-binding transcription factor activity
HUW87_02805	COG1053	succinate dehydrogenase
HUW87_02810	COG0471	metal ion transport
HUW87_02815	COG0039	L-malate dehydrogenase activity
HUW87_02820	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
HUW87_02825	COG0215	cysteine-tRNA ligase activity
HUW87_02830	COG0626	cystathionine gamma-synthase activity
HUW87_02835	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HUW87_02840	COG1464	Belongs to the NlpA lipoprotein family
HUW87_02845	COG1854	S-ribosylhomocysteine lyase activity
HUW87_02850	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
HUW87_02855	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HUW87_02870	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HUW87_02875	COG0250	Participates in transcription elongation, termination and antitermination
HUW87_02880	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HUW87_02885	COG0081	regulation of translation
HUW87_02890	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HUW87_02895	COG0222	ribosome binding
HUW87_02915	COG1121	(ABC) transporter
HUW87_02920	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HUW87_02925	COG0803	Belongs to the bacterial solute-binding protein 9 family
HUW87_02930	COG1252	NADH dehydrogenase
HUW87_02940	COG1122	ATPase activity
HUW87_02945	COG1122	ATPase activity
HUW87_02955	COG0101	tRNA pseudouridine synthase activity
HUW87_02960	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HUW87_02985	COG0028	Belongs to the TPP enzyme family
HUW87_03000	COG1573	uracil-dna glycosylase
HUW87_03015	COG0366	Alpha amylase catalytic
HUW87_03025	COG0671	phosphoesterase, PA-phosphatase related
HUW87_03030	COG2226	methyltransferase
HUW87_03045	COG2814	Major facilitator Superfamily
HUW87_03050	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HUW87_03065	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HUW87_03070	COG1481	regulation of sporulation
HUW87_03075	COG0740	serine-type endopeptidase activity
HUW87_03090	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HUW87_03090	COG1263	PTS System
HUW87_03100	COG1914	H( )-stimulated, divalent metal cation uptake system
HUW87_03120	COG0582	viral genome integration into host DNA
HUW87_03125	COG3759	membrane
HUW87_03135	COG1396	sequence-specific DNA binding
HUW87_03225	COG1122	ATPase activity
HUW87_03230	COG1122	ATPase activity
HUW87_03240	COG4166	transmembrane transport
HUW87_03245	COG1228	amidohydrolase
HUW87_03295	COG2801	Transposase and inactivated derivatives
HUW87_03305	COG0039	L-malate dehydrogenase activity
HUW87_03310	COG0028	Belongs to the TPP enzyme family
HUW87_03315	COG3527	Alpha-acetolactate decarboxylase
HUW87_03325	COG3942	CHAP domain
HUW87_03325	COG1388	LysM domain
HUW87_03330	COG0791	NLP P60 protein
HUW87_03340	COG0756	dUTP diphosphatase activity
HUW87_03350	COG4956	integral membrane protein (PIN domain superfamily)
HUW87_03360	COG0653	protein targeting
HUW87_03365	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HUW87_03380	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HUW87_03390	COG1733	regulation of RNA biosynthetic process
HUW87_03395	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HUW87_03400	COG0072	phenylalanine-tRNA ligase activity
HUW87_03400	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HUW87_03405	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HUW87_03410	COG0514	ATP-dependent DNA helicase (RecQ)
HUW87_03415	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HUW87_03425	COG0768	penicillin binding
HUW87_03430	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HUW87_03445	COG1940	carbohydrate kinase activity
HUW87_03460	COG3942	CHAP domain
HUW87_03480	COG0584	glycerophosphoryl diester phosphodiesterase
HUW87_03485	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HUW87_03490	COG0789	Transcriptional regulator
HUW87_03495	COG0174	glutamine synthetase
HUW87_03520	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HUW87_03525	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HUW87_03530	COG1472	Belongs to the glycosyl hydrolase 3 family
HUW87_03560	COG0778	Nitroreductase
HUW87_03565	COG1169	isochorismate synthase
HUW87_03570	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HUW87_03575	COG0596	Alpha beta hydrolase
HUW87_03580	COG4948	Mandelate Racemase Muconate Lactonizing
HUW87_03610	COG0737	Belongs to the 5'-nucleotidase family
HUW87_03615	COG4470	Protein conserved in bacteria
HUW87_03620	COG0647	UMP catabolic process
HUW87_03625	COG4166	transmembrane transport
HUW87_03630	COG0673	inositol 2-dehydrogenase activity
HUW87_03670	COG0573	inorganic phosphate transmembrane transporter activity
HUW87_03675	COG0581	inorganic phosphate transmembrane transporter activity
HUW87_03680	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HUW87_03685	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HUW87_03690	COG0704	Plays a role in the regulation of phosphate uptake
HUW87_03695	COG2137	regulation of response to DNA damage stimulus
HUW87_03730	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HUW87_03740	COG5506	Protein of unknown function (DUF1694)
HUW87_03750	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HUW87_03860	COG1272	protein, Hemolysin III
HUW87_03890	COG0525	valine-tRNA ligase activity
HUW87_03900	COG0285	dihydrofolate synthase activity
HUW87_03930	COG0488	(ABC) transporter
HUW87_03935	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HUW87_03940	COG0459	protein refolding
HUW87_03945	COG0531	amino acid
HUW87_03955	COG1181	Belongs to the D-alanine--D-alanine ligase family
HUW87_03960	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
HUW87_03965	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HUW87_03975	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HUW87_03980	COG1713	HD superfamily hydrolase involved in NAD metabolism
HUW87_03985	COG0799	negative regulation of ribosome biogenesis
HUW87_03990	COG2226	methyltransferase
HUW87_03995	COG1323	Belongs to the UPF0348 family
HUW87_04005	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HUW87_04010	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HUW87_04110	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HUW87_04115	COG3764	Sortase (surface protein transpeptidase)
HUW87_04120	COG0363	glucosamine-6-phosphate deaminase activity
HUW87_04125	COG0776	regulation of translation
HUW87_04135	COG0577	efflux transmembrane transporter activity
HUW87_04140	COG1136	(ABC) transporter
HUW87_04155	COG4720	Psort location CytoplasmicMembrane, score
HUW87_04160	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HUW87_04165	COG1570	exodeoxyribonuclease VII activity
HUW87_04180	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
HUW87_04185	COG1438	arginine binding
HUW87_04190	COG0497	DNA recombination
HUW87_04200	COG0194	GDP metabolic process
HUW87_04210	COG0586	Pfam SNARE associated Golgi protein
HUW87_04215	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HUW87_04220	COG1098	S1 RNA binding domain
HUW87_04335	COG4684	Psort location CytoplasmicMembrane, score
HUW87_04340	COG1271	oxidase subunit
HUW87_04345	COG1294	oxidase, subunit
HUW87_04350	COG4988	ABC transporter
HUW87_04355	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HUW87_04360	COG1388	LysM domain
HUW87_04360	COG1705	Flagellar rod assembly protein muramidase FlgJ
HUW87_04365	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
HUW87_04380	COG1278	Cold shock
HUW87_04385	COG0494	nUDIX hydrolase
HUW87_04395	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HUW87_04400	COG0346	lactoylglutathione lyase activity
HUW87_04405	COG0400	carboxylic ester hydrolase activity
HUW87_04420	COG2801	Transposase and inactivated derivatives
HUW87_04425	COG0741	lytic transglycosylase activity
HUW87_04445	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HUW87_04450	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HUW87_04455	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HUW87_04465	COG4120	Belongs to the binding-protein-dependent transport system permease family
HUW87_04475	COG0038	chloride channel
HUW87_04480	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HUW87_04485	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HUW87_04490	COG1307	EDD domain protein, DegV family
HUW87_04495	COG1263	PTS System
HUW87_04495	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HUW87_04495	COG2190	(PTS) system
HUW87_04515	COG1077	Cell shape determining protein MreB Mrl
HUW87_04525	COG3338	carbonate dehydratase activity
HUW87_04535	COG0765	amino acid transport
HUW87_04540	COG1126	abc transporter atp-binding protein
HUW87_04545	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HUW87_04550	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HUW87_04550	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HUW87_04555	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HUW87_04560	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HUW87_04565	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HUW87_04570	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HUW87_04575	COG0047	phosphoribosylformylglycinamidine synthase activity
HUW87_04580	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HUW87_04590	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HUW87_04595	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HUW87_04600	COG0138	bifunctional purine biosynthesis protein purh
HUW87_04605	COG0151	Belongs to the GarS family
HUW87_04610	COG2759	Belongs to the formate--tetrahydrofolate ligase family
HUW87_04625	COG0446	pyridine nucleotide-disulphide oxidoreductase
HUW87_04645	COG0833	amino acid
HUW87_04655	COG2264	protein methyltransferase activity
HUW87_04660	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HUW87_04670	COG2001	Belongs to the MraZ family
HUW87_04675	COG0275	rRNA processing
HUW87_04685	COG0768	penicillin binding
HUW87_04690	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HUW87_04695	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HUW87_04700	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HUW87_04705	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HUW87_04710	COG0849	cell division
HUW87_04720	COG1799	cell septum assembly
HUW87_04735	COG3599	regulation of cell shape
HUW87_04755	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HUW87_04760	COG0217	transcriptional regulatory protein
HUW87_04765	COG2252	PERMEase
HUW87_04770	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HUW87_04810	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HUW87_04815	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HUW87_04820	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HUW87_04825	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HUW87_04825	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HUW87_04830	COG0631	protein serine/threonine phosphatase activity
HUW87_04835	COG0515	serine threonine protein kinase
HUW87_04835	COG2815	serine threonine protein kinase
HUW87_04840	COG1162	GTPase activity
HUW87_04845	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HUW87_04855	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HUW87_04865	COG1461	Dihydroxyacetone kinase
HUW87_04875	COG0438	transferase activity, transferring glycosyl groups
HUW87_04890	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HUW87_04895	COG0416	fatty acid biosynthetic process
HUW87_04900	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HUW87_04905	COG0571	ribonuclease III activity
HUW87_04910	COG1196	nuclear chromosome segregation
HUW87_04915	COG0552	protein localization to endoplasmic reticulum
HUW87_04920	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
HUW87_04925	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HUW87_04945	COG0228	four-way junction DNA binding
HUW87_04950	COG0582	viral genome integration into host DNA
HUW87_05035	COG0629	single-stranded DNA binding
HUW87_05060	COG2801	Transposase and inactivated derivatives
HUW87_05130	COG0588	phosphoglycerate mutase activity
HUW87_05135	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HUW87_05140	COG0336	Belongs to the RNA methyltransferase TrmD family
HUW87_05145	COG0335	large ribosomal subunit rRNA binding
HUW87_05155	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HUW87_05160	COG1942	4-Oxalocrotonate Tautomerase
HUW87_05165	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HUW87_05175	COG1428	Deoxynucleoside kinase
HUW87_05180	COG1970	mechanosensitive ion channel activity
HUW87_05185	COG0561	phosphatase activity
HUW87_05255	COG3853	Toxic anion resistance protein (TelA)
HUW87_05260	COG1393	Belongs to the ArsC family
HUW87_05265	COG4862	establishment of competence for transformation
HUW87_05270	COG2723	6-phospho-beta-galactosidase activity
HUW87_05275	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HUW87_05280	COG1447	Phosphotransferase system cellobiose-specific component IIA
HUW87_05285	COG2723	6-phospho-beta-galactosidase activity
HUW87_05300	COG2801	Transposase and inactivated derivatives
HUW87_05315	COG1164	Oligoendopeptidase f
HUW87_05320	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HUW87_05335	COG1609	Transcriptional regulator
HUW87_05340	COG0006	proline dipeptidase activity
HUW87_05415	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HUW87_05420	COG3425	synthase
HUW87_05435	COG0860	N-Acetylmuramoyl-L-alanine amidase
HUW87_05440	COG0124	histidyl-tRNA synthetase
HUW87_05445	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HUW87_05460	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HUW87_05465	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HUW87_05470	COG1610	YqeY-like protein
HUW87_05475	COG1702	phosphate starvation-inducible protein PhoH
HUW87_05480	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HUW87_05485	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HUW87_05490	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HUW87_05495	COG1381	Involved in DNA repair and RecF pathway recombination
HUW87_05510	COG0752	glycyl-tRNA synthetase alpha subunit
HUW87_05515	COG0751	glycine-tRNA ligase activity
HUW87_05535	COG2706	6-phosphogluconolactonase activity
HUW87_05540	COG0628	permease
HUW87_05550	COG1674	ftsk spoiiie
HUW87_05560	COG4152	abc transporter atp-binding protein
HUW87_05565	COG1668	transmembrane transport
HUW87_05575	COG0322	excinuclease ABC activity
HUW87_05585	COG1739	Uncharacterized protein family UPF0029
HUW87_05600	COG0516	GMP reductase activity
HUW87_05600	COG0517	IMP dehydrogenase activity
HUW87_05605	COG0516	GMP reductase activity
HUW87_05605	COG0517	IMP dehydrogenase activity
HUW87_05610	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HUW87_05615	COG0632	four-way junction helicase activity
HUW87_05620	COG2255	four-way junction helicase activity
HUW87_05625	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HUW87_05660	COG0343	queuine tRNA-ribosyltransferase activity
HUW87_05665	COG1862	Preprotein translocase
HUW87_05670	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HUW87_05675	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HUW87_05680	COG0513	Belongs to the DEAD box helicase family
HUW87_05685	COG1929	Belongs to the glycerate kinase type-1 family
HUW87_05690	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HUW87_05710	COG3906	Belongs to the UPF0473 family
HUW87_05725	COG1466	dna polymerase III delta subunit
HUW87_05730	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HUW87_05735	COG0268	Binds directly to 16S ribosomal RNA
HUW87_05760	COG0544	peptidyl-prolyl cis-trans isomerase activity
HUW87_05765	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HUW87_05770	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HUW87_05790	COG1193	negative regulation of DNA recombination
HUW87_05815	COG3118	belongs to the thioredoxin family
HUW87_05820	COG0187	DNA topoisomerase II activity
HUW87_05825	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HUW87_05830	COG3527	Alpha-acetolactate decarboxylase
HUW87_05835	COG1473	amidohydrolase
HUW87_05850	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HUW87_05875	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HUW87_05880	COG3201	nicotinamide mononucleotide transporter
HUW87_05915	COG0028	Belongs to the TPP enzyme family
HUW87_05920	COG2801	Transposase and inactivated derivatives
HUW87_05980	COG0277	FAD linked oxidase domain protein
HUW87_05985	COG0436	Aminotransferase
HUW87_06000	COG1464	Belongs to the NlpA lipoprotein family
HUW87_06015	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
HUW87_06020	COG0351	phosphomethylpyrimidine kinase
HUW87_06025	COG0352	thiamine-phosphate diphosphorylase activity
HUW87_06045	COG1028	Short-chain dehydrogenase reductase Sdr
HUW87_06055	COG1940	carbohydrate kinase activity
HUW87_06135	COG0546	phosphoglycolate phosphatase activity
HUW87_06140	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HUW87_06145	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HUW87_06160	COG3513	CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
HUW87_06165	COG1518	maintenance of DNA repeat elements
HUW87_06170	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
HUW87_06185	COG2357	RelA SpoT domain protein
HUW87_06190	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HUW87_06195	COG0564	pseudouridine synthase activity
HUW87_06200	COG2239	Acts as a magnesium transporter
HUW87_06210	COG0456	acetyltransferase
HUW87_06265	COG2801	Transposase and inactivated derivatives
HUW87_06280	COG2207	Transcriptional regulator
HUW87_06280	COG4753	response regulator
HUW87_06290	COG0384	phenazine biosynthesis protein PhzF
HUW87_06300	COG1621	beta-fructofuranosidase activity
HUW87_06320	COG1033	growth of symbiont in host cell
HUW87_06320	COG2409	Drug exporters of the RND superfamily
HUW87_06325	COG4684	Psort location CytoplasmicMembrane, score
HUW87_06340	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HUW87_06345	COG0738	Major facilitator superfamily
HUW87_06350	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HUW87_06380	COG1304	FMN binding
HUW87_06395	COG0779	Required for maturation of 30S ribosomal subunits
HUW87_06400	COG0195	Participates in both transcription termination and antitermination
HUW87_06405	COG2740	Nucleic-acid-binding protein implicated in transcription termination
HUW87_06415	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HUW87_06420	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HUW87_06425	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HUW87_06440	COG0196	riboflavin kinase activity
HUW87_06445	COG1293	RNA-binding protein homologous to eukaryotic snRNP
HUW87_06450	COG3142	Participates in the control of copper homeostasis
HUW87_06465	COG2270	Major facilitator Superfamily
HUW87_06470	COG1307	EDD domain protein, DegV family
HUW87_06475	COG1307	EDD domain protein, DegV family
HUW87_06480	COG2755	lipolytic protein G-D-S-L family
HUW87_06490	COG4479	Belongs to the UPF0346 family
HUW87_06500	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HUW87_06510	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HUW87_06515	COG4974	Belongs to the 'phage' integrase family
HUW87_06525	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HUW87_06545	COG3448	diguanylate cyclase activity
HUW87_06545	COG4175	Glycine betaine
HUW87_06560	COG0446	pyridine nucleotide-disulphide oxidoreductase
HUW87_06565	COG1464	Belongs to the NlpA lipoprotein family
HUW87_06570	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HUW87_06575	COG1597	lipid kinase activity
HUW87_06580	COG1011	Hydrolase
HUW87_06600	COG5503	Protein of unknown function (DUF1447)
HUW87_06615	COG0242	peptide deformylase activity
HUW87_06620	COG4476	Belongs to the UPF0223 family
HUW87_06625	COG0483	inositol monophosphate 1-phosphatase activity
HUW87_06630	COG1217	gtp-binding protein TYPA
HUW87_06635	COG0772	Belongs to the SEDS family
HUW87_06640	COG4471	UPF0298 protein
HUW87_06645	COG0742	ribosomal rna small subunit methyltransferase
HUW87_06650	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HUW87_06655	COG3480	Lon protease (S16) C-terminal proteolytic domain
HUW87_06660	COG0477	Major facilitator Superfamily
HUW87_06670	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
HUW87_06675	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HUW87_06680	COG0358	DNA primase activity
HUW87_06685	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HUW87_06715	COG0745	RESPONSE REGULATOR receiver
HUW87_06720	COG5002	protein histidine kinase activity
HUW87_06725	COG0572	uridine kinase
HUW87_06730	COG1363	Peptidase, m42
HUW87_06735	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HUW87_06745	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HUW87_06750	COG0670	Belongs to the BI1 family
HUW87_06755	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HUW87_06755	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HUW87_06760	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HUW87_06765	COG0237	dephospho-CoA kinase activity
HUW87_06775	COG1484	DNA-dependent DNA replication
HUW87_06790	COG0745	RESPONSE REGULATOR receiver
HUW87_06795	COG5002	protein histidine kinase activity
HUW87_06805	COG3942	CHAP domain
HUW87_06805	COG1705	Flagellar rod assembly protein muramidase FlgJ
HUW87_06810	COG2801	Transposase and inactivated derivatives
HUW87_06840	COG0706	membrane insertase activity
HUW87_06845	COG1028	Short-chain dehydrogenase reductase Sdr
HUW87_06850	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HUW87_06860	COG1304	FMN binding
HUW87_06880	COG1199	ATP-dependent helicase activity
HUW87_06880	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HUW87_06890	COG0017	Asparaginyl-tRNA synthetase
HUW87_06895	COG3935	DnaD domain protein
HUW87_06905	COG3331	DNA recombination
HUW87_06910	COG4474	Belongs to the UPF0398 family
HUW87_06915	COG3599	regulation of cell shape
HUW87_06925	COG0116	Belongs to the methyltransferase superfamily
HUW87_06935	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HUW87_06955	COG0556	nucleotide-excision repair
HUW87_06965	COG0439	Biotin carboxylase
HUW87_06970	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HUW87_06980	COG3104	oligopeptide transport
HUW87_06995	COG2801	Transposase and inactivated derivatives
HUW87_07010	COG0537	adenosine 5'-monophosphoramidase activity
HUW87_07015	COG1131	(ABC) transporter
HUW87_07025	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HUW87_07030	COG1719	4-vinyl reductase, 4VR
HUW87_07035	COG1397	ADP-ribosylglycohydrolase
HUW87_07045	COG2801	Transposase and inactivated derivatives
HUW87_07075	COG0446	pyridine nucleotide-disulphide oxidoreductase
HUW87_07080	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
HUW87_07085	COG1349	DNA-binding transcription factor activity
HUW87_07090	COG1105	Belongs to the carbohydrate kinase PfkB family
HUW87_07095	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HUW87_07095	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HUW87_07095	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HUW87_07105	COG1609	Transcriptional regulator
HUW87_07115	COG0306	phosphate transporter
HUW87_07130	COG2723	6-phospho-beta-galactosidase activity
HUW87_07150	COG0531	amino acid
HUW87_07160	COG0481	GTPase activity
HUW87_07195	COG1028	Short-chain dehydrogenase reductase Sdr
HUW87_07200	COG4708	membrane
HUW87_07210	COG0531	amino acid
HUW87_07215	COG4221	oxidoreductase activity
HUW87_07235	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HUW87_07250	COG1136	(ABC) transporter
HUW87_07255	COG0577	efflux transmembrane transporter activity
HUW87_07265	COG2801	Transposase and inactivated derivatives
HUW87_07275	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HUW87_07285	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HUW87_07290	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HUW87_07320	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HUW87_07325	COG2384	SAM-dependent methyltransferase
HUW87_07330	COG0071	Belongs to the small heat shock protein (HSP20) family
HUW87_07335	COG0457	Tetratricopeptide repeat
HUW87_07380	COG0419	ATPase involved in DNA repair
HUW87_07385	COG0420	3'-5' exonuclease activity
HUW87_07395	COG2807	transmembrane transport
HUW87_07400	COG4720	Psort location CytoplasmicMembrane, score
HUW87_07405	COG0351	phosphomethylpyrimidine kinase
HUW87_07415	COG1160	GTP binding
HUW87_07420	COG0539	negative regulation of cytoplasmic translation
HUW87_07425	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HUW87_07435	COG0514	ATP-dependent DNA helicase (RecQ)
HUW87_07445	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
HUW87_07460	COG1187	pseudouridine synthase activity
HUW87_07465	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HUW87_07470	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HUW87_07485	COG2996	Protein conserved in bacteria
HUW87_07495	COG0475	glutathione-regulated potassium exporter activity
HUW87_07505	COG1490	D-aminoacyl-tRNA deacylase activity
HUW87_07510	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HUW87_07515	COG0587	DNA-directed DNA polymerase activity
HUW87_07525	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HUW87_07530	COG0488	(ABC) transporter
HUW87_07535	COG0617	tRNA 3'-terminal CCA addition
HUW87_07545	COG2801	Transposase and inactivated derivatives
HUW87_07550	COG1136	(ABC) transporter
HUW87_07565	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HUW87_07570	COG0004	ammonium transporteR
HUW87_07580	COG5263	repeat protein
HUW87_07580	COG0366	Alpha amylase catalytic
HUW87_07585	COG1316	TRANSCRIPTIONal
HUW87_07590	COG1216	Glycosyl transferase, family 2
HUW87_07605	COG1216	Glycosyl transferase, family 2
HUW87_07615	COG0438	transferase activity, transferring glycosyl groups
HUW87_07620	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HUW87_07625	COG0489	protein tyrosine kinase activity
HUW87_07640	COG0233	cytoplasmic translational termination
HUW87_07650	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HUW87_07655	COG0052	Belongs to the universal ribosomal protein uS2 family
HUW87_07660	COG2827	Endonuclease containing a URI domain
HUW87_07665	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HUW87_07670	COG0204	Acyl-transferase
HUW87_07675	COG3883	PFAM NLP P60 protein
HUW87_07675	COG0791	NLP P60 protein
HUW87_07690	COG3763	UPF0154 protein
HUW87_07695	COG4224	UPF0291 protein
HUW87_07700	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HUW87_07720	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HUW87_07720	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HUW87_07725	COG1234	tRNA 3'-trailer cleavage
HUW87_07740	COG0484	heat shock protein binding
HUW87_07745	COG0443	Heat shock 70 kDa protein
HUW87_07755	COG1420	regulation of RNA biosynthetic process
HUW87_07785	COG1216	Glycosyl transferase, family 2
HUW87_07795	COG0463	Glycosyl transferase, family 2
HUW87_07805	COG1705	Flagellar rod assembly protein muramidase FlgJ
HUW87_07820	COG0562	UDP-galactopyranose mutase
HUW87_07845	COG0024	Methionine aminopeptidase
HUW87_07865	COG1388	LysM domain
HUW87_07865	COG1705	Flagellar rod assembly protein muramidase FlgJ
HUW87_07895	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HUW87_07905	COG1682	transport, permease protein
HUW87_07910	COG1388	LysM domain
HUW87_07910	COG1134	teichoic acid transport
HUW87_07915	COG1063	alcohol dehydrogenase
HUW87_07920	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HUW87_07925	COG3475	LICD family
HUW87_07945	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HUW87_07975	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HUW87_08095	COG0463	Glycosyl transferase, family 2
HUW87_08110	COG3706	GGDEF domain
HUW87_08125	COG2801	Transposase and inactivated derivatives
HUW87_08165	COG2309	aminopeptidase activity
HUW87_08180	COG0564	pseudouridine synthase activity
HUW87_08185	COG1278	Cold shock
HUW87_08195	COG2814	Major facilitator Superfamily
HUW87_08200	COG0741	lytic transglycosylase activity
HUW87_08210	COG3973	AAA domain
HUW87_08220	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HUW87_08225	COG1058	Belongs to the CinA family
HUW87_08225	COG1546	Belongs to the CinA family
HUW87_08230	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HUW87_08235	COG1426	Protein conserved in bacteria
HUW87_08240	COG0612	Peptidase, M16
HUW87_08245	COG0612	Peptidase, M16
HUW87_08260	COG0028	Belongs to the TPP enzyme family
HUW87_08280	COG4717	serine-type aminopeptidase activity
HUW87_08290	COG3679	Belongs to the UPF0342 family
HUW87_08295	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HUW87_08300	COG1438	arginine binding
HUW87_08320	COG0018	arginyl-trna synthetase
HUW87_08335	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HUW87_08345	COG1121	(ABC) transporter
HUW87_08365	COG1597	lipid kinase activity
HUW87_08370	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HUW87_08375	COG0154	amidase activity
HUW87_08380	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HUW87_08385	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HUW87_08385	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
HUW87_08395	COG2936	dipeptidyl-peptidase activity
HUW87_08410	COG1695	Transcriptional regulator
HUW87_08420	COG1914	H( )-stimulated, divalent metal cation uptake system
HUW87_08440	COG0667	Aldo Keto reductase
HUW87_08445	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HUW87_08450	COG4721	ABC-type cobalt transport system, permease component
HUW87_08455	COG1122	ATPase activity
HUW87_08470	COG0710	3-dehydroquinate dehydratase activity
HUW87_08475	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HUW87_08480	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HUW87_08485	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HUW87_08490	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HUW87_08495	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HUW87_08500	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HUW87_08515	COG4684	Psort location CytoplasmicMembrane, score
HUW87_08520	COG0436	Aminotransferase
HUW87_08610	COG0228	four-way junction DNA binding
HUW87_08640	COG1783	phage Terminase large subunit
HUW87_08730	COG0629	single-stranded DNA binding
HUW87_08785	COG1396	sequence-specific DNA binding
HUW87_08805	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HUW87_08810	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HUW87_08815	COG0436	Aminotransferase
HUW87_08820	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HUW87_08825	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HUW87_08835	COG2171	N-acyltransferase activity
HUW87_08840	COG0019	diaminopimelate decarboxylase activity
HUW87_08845	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HUW87_08850	COG0527	aspartate kinase activity
HUW87_08860	COG1609	Transcriptional regulator
HUW87_08865	COG0083	homoserine kinase activity
HUW87_08880	COG1321	iron dependent repressor
HUW87_08885	COG3764	Sortase (surface protein transpeptidase)
HUW87_08905	COG0513	Belongs to the DEAD box helicase family
HUW87_08910	COG0673	inositol 2-dehydrogenase activity
HUW87_08915	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HUW87_08925	COG2801	Transposase and inactivated derivatives
HUW87_08935	COG0501	Belongs to the peptidase M48B family
HUW87_08940	COG1704	LemA family
HUW87_08950	COG4115	mRNA cleavage
HUW87_08955	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HUW87_08970	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HUW87_08980	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HUW87_08985	COG0439	Biotin carboxylase
HUW87_09000	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HUW87_09005	COG1028	Short-chain dehydrogenase reductase Sdr
HUW87_09010	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HUW87_09015	COG2070	2-Nitropropane dioxygenase
HUW87_09020	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HUW87_09025	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HUW87_09030	COG1846	Transcriptional regulator
HUW87_09035	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HUW87_09045	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HUW87_09050	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HUW87_09060	COG0505	Belongs to the CarA family
HUW87_09070	COG0564	pseudouridine synthase activity
HUW87_09080	COG0328	RNA-DNA hybrid ribonuclease activity
HUW87_09085	COG1757	Na H antiporter
HUW87_09090	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HUW87_09095	COG1113	amino acid transport
HUW87_09110	COG2801	Transposase and inactivated derivatives
HUW87_09210	COG2801	Transposase and inactivated derivatives
HUW87_09225	COG1396	sequence-specific DNA binding
HUW87_09245	COG4974	Belongs to the 'phage' integrase family
HUW87_09260	COG0656	L-ascorbic acid biosynthetic process
HUW87_09270	COG1454	alcohol dehydrogenase
HUW87_09270	COG1012	belongs to the aldehyde dehydrogenase family
HUW87_09275	COG0105	UTP biosynthetic process
HUW87_09285	COG0583	DNA-binding transcription factor activity
HUW87_09290	COG0126	phosphoglycerate kinase activity
HUW87_09340	COG0588	phosphoglycerate mutase activity
HUW87_09350	COG3716	PTS system mannose fructose sorbose family IID component
HUW87_09355	COG3715	PTS system
HUW87_09375	COG2801	Transposase and inactivated derivatives
HUW87_09380	COG1397	ADP-ribosylglycohydrolase
HUW87_09440	COG1368	sulfuric ester hydrolase activity
HUW87_09455	COG0438	transferase activity, transferring glycosyl groups
HUW87_09460	COG0438	transferase activity, transferring glycosyl groups
HUW87_09465	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HUW87_09470	COG0284	orotidine-5'-phosphate decarboxylase activity
HUW87_09475	COG0167	dihydroorotate dehydrogenase activity
HUW87_09480	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HUW87_09485	COG0505	Belongs to the CarA family
HUW87_09490	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HUW87_09495	COG0540	Belongs to the ATCase OTCase family
HUW87_09515	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HUW87_09520	COG4856	YbbR-like protein
HUW87_09535	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HUW87_09540	COG2176	DNA-directed DNA polymerase activity
HUW87_09550	COG0802	atpase or kinase
HUW87_09555	COG0280	phosphate acetyltransferase
HUW87_09560	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HUW87_09570	COG2076	Multidrug Resistance protein
HUW87_09575	COG2076	Multidrug Resistance protein
HUW87_09580	COG1126	abc transporter atp-binding protein
HUW87_09585	COG0765	amino acid transport
HUW87_09590	COG2814	Major facilitator Superfamily
HUW87_09605	COG0557	exoribonuclease II activity
HUW87_09615	COG2814	Major facilitator Superfamily
HUW87_09620	COG0154	amidase activity
HUW87_09640	COG0149	triose-phosphate isomerase activity
HUW87_09645	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HUW87_09650	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HUW87_09660	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HUW87_09665	COG0492	ferredoxin-NADP+ reductase activity
HUW87_09685	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HUW87_09690	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HUW87_09695	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
HUW87_09700	COG1950	PFAM Membrane protein of
HUW87_09710	COG0589	response to stress
HUW87_09720	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HUW87_09730	COG1177	transmembrane transport
HUW87_09740	COG3842	ATPase activity
HUW87_09750	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HUW87_09755	COG0049	tRNA binding
HUW87_09760	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HUW87_09765	COG4608	Belongs to the ABC transporter superfamily
HUW87_09770	COG0444	Belongs to the ABC transporter superfamily
HUW87_09775	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HUW87_09780	COG0601	transmembrane transport
HUW87_09795	COG0460	homoserine dehydrogenase
HUW87_09800	COG0626	cystathionine gamma-synthase activity
HUW87_09805	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
HUW87_09815	COG1744	ABC transporter substrate-binding protein PnrA-like
HUW87_09820	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HUW87_09825	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HUW87_09840	COG1302	Protein conserved in bacteria
HUW87_09845	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HUW87_09855	COG2017	converts alpha-aldose to the beta-anomer
HUW87_09865	COG4975	Glucose uptake
HUW87_09870	COG2801	Transposase and inactivated derivatives
HUW87_09880	COG3850	Histidine kinase
HUW87_09880	COG5002	protein histidine kinase activity
HUW87_09885	COG0745	RESPONSE REGULATOR receiver
HUW87_09890	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HUW87_09895	COG0402	S-adenosylhomocysteine deaminase activity
HUW87_09900	COG0673	inositol 2-dehydrogenase activity
HUW87_09905	COG0741	lytic transglycosylase activity
HUW87_09925	COG0668	transmembrane transport
HUW87_09935	COG1126	abc transporter atp-binding protein
HUW87_09940	COG0765	amino acid transport
HUW87_09980	COG0516	GMP reductase activity
HUW87_10060	COG2801	Transposase and inactivated derivatives
HUW87_10090	COG0738	Major facilitator superfamily
HUW87_10095	COG1869	D-ribose catabolic process
HUW87_10100	COG1609	Transcriptional regulator
HUW87_10120	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HUW87_10135	COG1609	Transcriptional regulator
HUW87_10150	COG2223	nitrite transmembrane transporter activity
HUW87_10160	COG0318	PFAM AMP-dependent synthetase and ligase
HUW87_10170	COG1116	anion transmembrane transporter activity
HUW87_10175	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HUW87_10185	COG0285	dihydrofolate synthase activity
HUW87_10190	COG0302	gtp cyclohydrolase
HUW87_10195	COG0302	gtp cyclohydrolase
HUW87_10195	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HUW87_10210	COG0561	phosphatase activity
HUW87_10220	COG0823	Involved in the tonB-independent uptake of proteins
HUW87_10220	COG1506	peptidase
HUW87_10220	COG4946	Tricorn protease homolog
HUW87_10225	COG1464	Belongs to the NlpA lipoprotein family
HUW87_10240	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HUW87_10255	COG1609	Transcriptional regulator
HUW87_10285	COG0577	efflux transmembrane transporter activity
HUW87_10290	COG1136	(ABC) transporter
HUW87_10295	COG3759	membrane
HUW87_10325	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HUW87_10330	COG2235	arginine
HUW87_10340	COG2217	Heavy metal translocating P-type atpase
HUW87_10390	COG0438	transferase activity, transferring glycosyl groups
HUW87_10435	COG2814	Major facilitator Superfamily
HUW87_10440	COG2217	Heavy metal translocating P-type atpase
HUW87_10460	COG1309	transcriptional regulator
HUW87_10480	COG3711	transcriptional antiterminator
HUW87_10485	COG2723	6-phospho-beta-galactosidase activity
HUW87_10490	COG1940	carbohydrate kinase activity
HUW87_10515	COG2183	response to ionizing radiation
HUW87_10525	COG2873	o-acetylhomoserine
HUW87_10530	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HUW87_10535	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
HUW87_10615	COG2176	DNA-directed DNA polymerase activity
HUW87_10620	COG0442	prolyl-tRNA aminoacylation
HUW87_10625	COG0750	zinc metalloprotease
HUW87_10630	COG4589	Belongs to the CDS family
HUW87_10635	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HUW87_10640	COG0561	phosphatase activity
HUW87_10645	COG2246	polysaccharide biosynthetic process
HUW87_10670	COG1811	Na channel or pump
HUW87_10675	COG1979	alcohol dehydrogenase
HUW87_10685	COG1174	glycine betaine transport
HUW87_10705	COG2801	Transposase and inactivated derivatives
HUW87_10720	COG1307	EDD domain protein, DegV family
HUW87_10725	COG0656	L-ascorbic acid biosynthetic process
HUW87_10730	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HUW87_10750	COG1228	amidohydrolase
HUW87_10755	COG4166	transmembrane transport
HUW87_10775	COG2826	transposase and inactivated derivatives, IS30 family
HUW87_10815	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
HUW87_10820	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HUW87_10830	COG2252	PERMEase
HUW87_10840	COG0352	thiamine-phosphate diphosphorylase activity
HUW87_10845	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
HUW87_10855	COG2814	Major facilitator Superfamily
HUW87_10860	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HUW87_10870	COG2188	Transcriptional regulator
HUW87_10880	COG0577	efflux transmembrane transporter activity
HUW87_10880	COG1136	(ABC) transporter
HUW87_10890	COG0561	phosphatase activity
HUW87_10895	COG2169	Transcriptional regulator
HUW87_10895	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HUW87_10900	COG0561	phosphatase activity
HUW87_10920	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HUW87_10925	COG0772	Belongs to the SEDS family
HUW87_10935	COG1077	Cell shape determining protein MreB Mrl
HUW87_10940	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HUW87_10945	COG1079	Belongs to the binding-protein-dependent transport system permease family
HUW87_10950	COG4603	Belongs to the binding-protein-dependent transport system permease family
HUW87_10955	COG3845	ABC transporter
HUW87_10960	COG1744	ABC transporter substrate-binding protein PnrA-like
HUW87_10965	COG2801	Transposase and inactivated derivatives
HUW87_10985	COG0640	Transcriptional regulator
HUW87_10990	COG0628	permease
HUW87_10995	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HUW87_11015	COG0386	Belongs to the glutathione peroxidase family
HUW87_11020	COG0588	phosphoglycerate mutase activity
HUW87_11035	COG0492	ferredoxin-NADP+ reductase activity
HUW87_11050	COG1744	ABC transporter substrate-binding protein PnrA-like
HUW87_11055	COG1744	ABC transporter substrate-binding protein PnrA-like
HUW87_11060	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HUW87_11065	COG2832	Protein of unknown function (DUF454)
HUW87_11090	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HUW87_11100	COG2814	Major facilitator Superfamily
HUW87_11105	COG0305	Participates in initiation and elongation during chromosome replication
HUW87_11110	COG0359	binds to the 23S rRNA
HUW87_11120	COG4608	Belongs to the ABC transporter superfamily
HUW87_11125	COG0444	Belongs to the ABC transporter superfamily
HUW87_11130	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HUW87_11135	COG0601	transmembrane transport
HUW87_11140	COG4166	transmembrane transport
HUW87_11145	COG0765	amino acid transport
HUW87_11150	COG0765	amino acid transport
HUW87_11155	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HUW87_11160	COG1126	abc transporter atp-binding protein
HUW87_11175	COG0194	GDP metabolic process
HUW87_11180	COG1268	BioY protein
HUW87_11185	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
HUW87_11185	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
HUW87_11215	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HUW87_11230	COG3973	AAA domain
HUW87_11250	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
HUW87_11260	COG1696	Membrane protein involved in D-alanine export
HUW87_11280	COG2337	Toxic component of a toxin-antitoxin (TA) module
HUW87_11295	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HUW87_11300	COG0504	CTP synthase activity
HUW87_11310	COG3343	RNA polymerase activity
HUW87_11315	COG0561	phosphatase activity
HUW87_11320	COG1078	dGTPase activity
HUW87_11330	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HUW87_11335	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HUW87_11355	COG0745	RESPONSE REGULATOR receiver
HUW87_11385	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HUW87_11390	COG0629	single-stranded DNA binding
HUW87_11395	COG0360	Binds together with S18 to 16S ribosomal RNA
HUW87_11410	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HUW87_11420	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HUW87_11425	COG1051	belongs to the nudix hydrolase family
HUW87_11440	COG2814	Major facilitator Superfamily
HUW87_11445	COG1064	alcohol dehydrogenase
HUW87_11450	COG1074	ATP-dependent DNA helicase activity
HUW87_11455	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
HUW87_11470	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HUW87_11475	COG0531	amino acid
HUW87_11480	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HUW87_11490	COG1902	pentaerythritol trinitrate reductase activity
HUW87_11495	COG0626	cystathionine gamma-synthase activity
HUW87_11515	COG2244	polysaccharide biosynthetic process
HUW87_11525	COG0438	transferase activity, transferring glycosyl groups
HUW87_11530	COG0495	leucyl-tRNA aminoacylation
HUW87_11535	COG0671	phosphoesterase, PA-phosphatase related
HUW87_11545	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HUW87_11570	COG2723	6-phospho-beta-galactosidase activity
HUW87_11590	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HUW87_11605	COG0024	Methionine aminopeptidase
HUW87_11615	COG1316	TRANSCRIPTIONal
HUW87_11625	COG2205	protein histidine kinase activity
HUW87_11630	COG0745	RESPONSE REGULATOR receiver
HUW87_11635	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HUW87_11650	COG2207	Transcriptional regulator
HUW87_11670	COG0308	aminopeptidase N
HUW87_11675	COG0833	amino acid
HUW87_11680	COG2040	homocysteine
HUW87_11685	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HUW87_11690	COG0542	response to heat
HUW87_11695	COG0308	aminopeptidase N
HUW87_11710	COG0395	ABC-type sugar transport system, permease component
HUW87_11715	COG1175	transmembrane transport
HUW87_11720	COG3842	ATPase activity
HUW87_11735	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HUW87_11770	COG2814	Major facilitator Superfamily
HUW87_11795	COG1914	H( )-stimulated, divalent metal cation uptake system
HUW87_11855	COG0438	transferase activity, transferring glycosyl groups
HUW87_11890	COG2084	Dehydrogenase
HUW87_11895	COG1028	Short-chain dehydrogenase reductase Sdr
HUW87_11905	COG1620	l-lactate permease
HUW87_11910	COG4989	oxidoreductase activity
HUW87_11915	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HUW87_11920	COG2233	PERMEase
HUW87_11935	COG1028	Short-chain dehydrogenase reductase Sdr
HUW87_11960	COG0783	Belongs to the Dps family
HUW87_11965	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HUW87_11990	COG2261	transglycosylase associated protein
HUW87_12010	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HUW87_12020	COG0492	ferredoxin-NADP+ reductase activity
HUW87_12030	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HUW87_12035	COG3118	belongs to the thioredoxin family
HUW87_12040	COG0640	Transcriptional regulator
HUW87_12050	COG1454	alcohol dehydrogenase
HUW87_12050	COG1012	belongs to the aldehyde dehydrogenase family
HUW87_12060	COG1573	uracil-dna glycosylase
HUW87_12065	COG2801	Transposase and inactivated derivatives
HUW87_12085	COG2017	converts alpha-aldose to the beta-anomer
HUW87_12175	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HUW87_12215	COG1063	alcohol dehydrogenase