locus-tag	class	description
B6254_0001	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
B6254_0002	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
B6254_0003	ENOG410848D	S4 domain protein YaaA
B6254_0004	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
B6254_0005	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
B6254_0006	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
B6254_0009	ENOG4105E0M	Sulfatase
B6254_0013	ENOG4105NDF	NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity)
B6254_0025	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
B6254_0026	ENOG4105EEQ	Na H antiporter
B6254_0027	ENOG4105F8V	Hydrolase, tatD family
B6254_0028	ENOG4105HVR	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity)
B6254_0030	ENOG4105C37	(CBS) domain
B6254_0031	ENOG4105C37	(CBS) domain
B6254_0032	ENOG4105W42	Veg protein
B6254_0033	ENOG4108UK2	deaminase
B6254_0034	ENOG4105C0V	Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity)
B6254_0035	ENOG4108KGH	TRANSCRIPTIONal
B6254_0036	ENOG4105C5Y	PTS System
B6254_0037	ENOG4105CS2	ec 3.2.1.21
B6254_0039	ENOG4105D5T	phosphonate abc transporter
B6254_0042	ENOG4107RNS	bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic
B6254_0044	ENOG41067S9	phage shock protein C, PspC
B6254_0048	ENOG4105DWR	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity)
B6254_0049	ENOG4108R3E	Dna-3-methyladenine glycosylase i
B6254_0053	ENOG4107QNK	)-transporter
B6254_0054	ENOG4105DSG	hydrolase family 43
B6254_0055	ENOG4105CT4	transporter
B6254_0057	ENOG4105C93	Xylose Isomerase
B6254_0058	ENOG4105CMG	Carbohydrate kinase
B6254_0059	ENOG4105CPC	Aldo Keto reductase
B6254_0063	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
B6254_0064	ENOG4105CK1	PTS System
B6254_0068	ENOG4105ECB	domain protein
B6254_0068	ENOG4105ECB	domain protein
B6254_0070	ENOG4105C9C	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity)
B6254_0071	ENOG4105C9C	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity)
B6254_0072	ENOG4105CNB	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity)
B6254_0073	ENOG4107QQ4	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity)
B6254_0074	ENOG4105CXW	Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity)
B6254_0077	ENOG4108ZPD	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity)
B6254_0078	ENOG4108JA2	transcriptioN-repair coupling factor
B6254_0080	ENOG41082I2	s4 domain protein
B6254_0085	ENOG4105F4C	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity)
B6254_0086	ENOG4105CRK	lysyL-tRNA synthetase
B6254_0099	ENOG4107BMA	Transglycosylase associated protein
B6254_0102	ENOG4106KNT	transcriptional regulator
B6254_0114	ENOG4107S6X	Glycosyl transferase, family 2
B6254_0116	ENOG4105CM2	brancheD-chain amino acid aminotransferase
B6254_0117	ENOG4105VZJ	PTS System
B6254_0118	ENOG4105VCP	PTS System
B6254_0119	ENOG4105CS2	ec 3.2.1.21
B6254_0120	ENOG4105CS2	ec 3.2.1.21
B6254_0121	ENOG4105CK1	PTS System
B6254_0123	ENOG4105CHM	Aminotransferase
B6254_0124	ENOG4105C5I	Dehydrogenase
B6254_0127	ENOG4107RBJ	symporter
B6254_0128	ENOG4105CRD	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity)
B6254_0129	ENOG4105CKN	UDP-glucose-hexose-1-phosphate uridylyltransferase
B6254_0130	ENOG4105C3U	ABC transporter
B6254_0131	ENOG4108JQ7	(ABC) transporter
B6254_0132	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
B6254_0133	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
B6254_0134	ENOG4105HJK	ABC transporter
B6254_0135	ENOG4105BZ1	(ABC) transporter
B6254_0136	ENOG4105BZ1	(ABC) transporter
B6254_0139	ENOG4108ZGC	gaf domain protein
B6254_0140	ENOG4105DC8	reductase
B6254_0143	ENOG4108UPS	Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity)
B6254_0144	ENOG4107RGM	aldo keto reductase
B6254_0145	ENOG4105DAA	L-lactate
B6254_0147	ENOG4105CHR	reductase
B6254_0148	ENOG4105CF3	3-Hydroxyisobutyrate dehydrogenase
B6254_0172	ENOG4105DC8	reductase
B6254_0175	ENOG4108IJ9	(ABC) transporter
B6254_0176	ENOG4105DB9	Binding-protein-dependent transport systems inner membrane component
B6254_0177	ENOG4105F66	Binding-protein-dependent transport systems inner membrane component
B6254_0180	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
B6254_0182	ENOG4108J5H	Homocysteine s-methyltransferase
B6254_0183	ENOG4108IQI	permease
B6254_0184	ENOG4105CD8	aminopeptidase N
B6254_0188	ENOG41075H3	AraC family transcriptional regulator
B6254_0191	ENOG4108HW8	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity)
B6254_0192	ENOG4108STX	response regulator
B6254_0195	ENOG4108KGH	TRANSCRIPTIONal
B6254_0197	ENOG4105CA1	Removes the N-terminal methionine from nascent proteins (By similarity)
B6254_0209	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
B6254_0211	ENOG410841Q	phosphoesterase PA-phosphatase related protein
B6254_0212	ENOG4105C8T	Leucyl-tRNA synthetase
B6254_0213	ENOG4105CG5	Glycosyl transferase (Group 1
B6254_0219	ENOG4105C28	cystathionine
B6254_0220	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
B6254_0222	ENOG4105C7Q	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity)
B6254_0223	ENOG4107R7I	amino acid
B6254_0224	ENOG4107QSE	Dipeptidase
B6254_0227	ENOG4105C5N	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
B6254_0228	ENOG4107R2I	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation
B6254_0230	ENOG410605W	Major Facilitator
B6254_0233	ENOG4108Z4K	mutator MutT protein
B6254_0234	ENOG4105DFT	pur operon repressor
B6254_0236	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
B6254_0237	ENOG4105DU0	nucleoside hydrolase
B6254_0239	ENOG4108ZDX	Binds together with S18 to 16S ribosomal RNA (By similarity)
B6254_0240	ENOG4108UUM	single-stranded DNA-binding protein
B6254_0247	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
B6254_0251	ENOG4105Q2H	domain protein
B6254_0252	ENOG4105C0H	protease
B6254_0254	ENOG4105DCI	Phosphohydrolase
B6254_0255	ENOG410667J	hydrolase
B6254_0256	ENOG4108Z1Y	Participates in both the initiation and recycling phases of transcription. In the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling (By similarity)
B6254_0261	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
B6254_0262	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
B6254_0263	ENOG4105C1J	atp-dependent rna helicase
B6254_0264	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
B6254_0265	ENOG4108YZM	Toxic component of a toxin-antitoxin (TA) module (By similarity)
B6254_0269	ENOG4105CK0	Membrane bOund o-acyl transferase mboat family protein
B6254_0271	ENOG4108M4D	D-alanyl-lipoteichoic acid biosynthesis protein DltD
B6254_0275	ENOG4105EEM	helicase
B6254_0278	ENOG4105DR1	Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity)
B6254_0279	ENOG4105CT4	transporter
B6254_0285	ENOG4105HJX	Biotin- acetyl-CoA-carboxylase ligase
B6254_0286	ENOG4105VKD	bioY protein
B6254_0287	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
B6254_0290	ENOG4105CDA	abc transporter atp-binding protein
B6254_0291	ENOG4105CT1	(ABC) transporter
B6254_0292	ENOG4105EAD	ABC transporter
B6254_0293	ENOG4105DRP	amino acid AbC transporter
B6254_0294	ENOG4108J59	Extracellular solute-binding protein, family 5
B6254_0296	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
B6254_0297	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
B6254_0299	ENOG4108JQ7	(ABC) transporter
B6254_0301	ENOG4105K9Q	Binds to the 23S rRNA (By similarity)
B6254_0302	ENOG4105CDU	Replicative dna helicase
B6254_0303	ENOG410605W	Major Facilitator
B6254_0305	ENOG4107PP3	Acetylornithine deacetylase
B6254_0311	ENOG4105WD1	Membrane
B6254_0312	ENOG4105CTR	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity)
B6254_0313	ENOG4105DIH	basic membrane
B6254_0314	ENOG4105DIH	basic membrane
B6254_0317	ENOG4105CAY	ferredoxin--nadp reductase
B6254_0320	ENOG4105DKJ	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
B6254_0321	ENOG4108V06	Glutathione peroxidase
B6254_0323	ENOG4105K8R	UPF0145 protein
B6254_0324	ENOG4105F0I	Aminotransferase
B6254_0326	ENOG4106F5Q	Membrane
B6254_0327	ENOG41080HT	Transcriptional regulator, arsr family
B6254_0329	ENOG4107QMW	pyridine nucleotide-disulfide oxidoreductase
B6254_0330	ENOG4105DIH	basic membrane
B6254_0331	ENOG4108JQ9	ABC transporter
B6254_0332	ENOG4105UIB	(ABC) transporter
B6254_0334	ENOG4107EES	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity)
B6254_0335	ENOG4105DFF	Rod shape-determining protein mreb
B6254_0338	ENOG4105II7	pyrroline-5-carboxylate reductase
B6254_0344	ENOG4105DQF	Hydrolase
B6254_0345	ENOG4105K85	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity)
B6254_0346	ENOG4108HCJ	Hydrolase
B6254_0348	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
B6254_0349	ENOG4105CE4	GlcNAc 6-P deacetylase
B6254_0350	ENOG4105FDP	GntR family transcriptional regulator
B6254_0353	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
B6254_0354	ENOG4105F27	Major Facilitator
B6254_0356	ENOG4105DGY	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization (By similarity)
B6254_0357	ENOG4108UV6	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity)
B6254_0359	ENOG4105C7N	Xanthine uracil vitamin C permease
B6254_0362	ENOG4108UGV	hypoxanthine phosphoribosyltransferase
B6254_0369	ENOG4105KEG	ribosomal-protein-alanine acetyltransferase
B6254_0372	ENOG4108J59	Extracellular solute-binding protein, family 5
B6254_0373	ENOG4105CI2	imidazolone-5-propionate hydrolase
B6254_0377	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
B6254_0379	ENOG4108RCR	degv family
B6254_0382	ENOG4107104	thymidine kinase
B6254_0384	ENOG4105KPY	Small multidrug resistance protein
B6254_0385	ENOG41080TC	multidrug resistance protein
B6254_0386	ENOG4105D1W	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity)
B6254_0387	ENOG4108R6K	riboflavin synthase, subunit alpha
B6254_0388	ENOG4105C66	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity)
B6254_0389	ENOG4108UTT	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity)
B6254_0391	ENOG4105E0X	reductase
B6254_0392	ENOG4108IJ8	ABC transporter
B6254_0393	ENOG4105E90	ABC transporter
B6254_0395	ENOG4107QW4	alcohol dehydrogenase
B6254_0396	ENOG4108UQV	Membrane
B6254_0401	ENOG4105WH5	Teichoic acid glycosylation protein
B6254_0402	ENOG4108HCJ	Hydrolase
B6254_0403	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
B6254_0404	ENOG4105KNE	Phosphatidate cytidylyltransferase
B6254_0405	ENOG4105DZP	Membrane-associated zinc metalloprotease
B6254_0406	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
B6254_0407	ENOG4105DE5	Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity)
B6254_0423	ENOG4105CVA	phosphate
B6254_0426	ENOG41081UC	Inherit from COG: Competence protein
B6254_0427	ENOG4105MS2	ribosomal subunit Interface protein
B6254_0434	ENOG41066F8	ROK family
B6254_0435	ENOG4105CS2	ec 3.2.1.21
B6254_0436	ENOG4105CID	antiterminator
B6254_0440	ENOG4108XFH	Transcriptional regulator
B6254_0452	ENOG4105C59	p-type ATPase
B6254_0453	ENOG4105E4Y	Endoribonuclease that initiates mRNA decay (By similarity)
B6254_0454	ENOG4105CEU	Arginine dihydrolase
B6254_0455	ENOG4105DBV	ornithine carbamoyltransferase
B6254_0456	ENOG4105D5Q	Arginine ornithine antiporter
B6254_0460	ENOG4105KA3	membrAne
B6254_0461	ENOG4105C19	ABC transporter
B6254_0468	ENOG4105ETE	Transcriptional regulator (LacI family
B6254_0471	ENOG4107URF	beta-phospho-glucomutase
B6254_0474	ENOG4105DEI	Mannitol dehydrogenase
B6254_0475	ENOG4105CHZ	Catalyzes the dehydration of D-mannonate (By similarity)
B6254_0476	ENOG4105D2H	Uronic isomerase
B6254_0477	ENOG4108UHU	Aldolase
B6254_0478	ENOG4105D7K	pfkb domain protein
B6254_0481	ENOG4105D01	(LipO)protein
B6254_0482	ENOG4105DRY	peptidase s9 prolyl oligopeptidase active site domain protein
B6254_0484	ENOG4108HCJ	Hydrolase
B6254_0489	ENOG4105EUJ	GTP cyclohydrolase i
B6254_0490	ENOG4105EUJ	GTP cyclohydrolase i
B6254_0491	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
B6254_0493	ENOG4105EFS	Binding-protein-dependent transport systems, inner membrane component
B6254_0494	ENOG4105E2Y	ABC, transporter
B6254_0496	ENOG4105CEY	Amp-dependent synthetase and ligase
B6254_0498	ENOG4105FCD	Major Facilitator
B6254_0506	ENOG4108M60	Transcriptional regulator
B6254_0509	ENOG4105D7K	pfkb domain protein
B6254_0513	ENOG4105ETE	Transcriptional regulator (LacI family
B6254_0514	ENOG4105MRB	Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity)
B6254_0515	ENOG4105EDR	glucose galactose transporter
B6254_0517	ENOG4105E66	phosphoriboisomerase A
B6254_0540	ENOG4108J59	Extracellular solute-binding protein, family 5
B6254_0541	ENOG4105CI2	imidazolone-5-propionate hydrolase
B6254_0543	ENOG4105CHR	reductase
B6254_0548	ENOG4107RAW	3-carboxy-cis-cis-muconate cycloisomerase
B6254_0551	ENOG4108HW4	amino acid AbC transporter
B6254_0552	ENOG4105CDA	abc transporter atp-binding protein
B6254_0554	ENOG4105D64	Mechanosensitive ion channel
B6254_0559	ENOG4105D9R	oxidoreductase
B6254_0560	ENOG4105DZC	cytosine deaminase
B6254_0562	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
B6254_0563	ENOG4105BZU	Histidine kinase
B6254_0564	ENOG4105CSC	Glucose uptake protein
B6254_0566	ENOG4105ENN	converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity)
B6254_0567	ENOG4107QYV	phosphohexose isomerase
B6254_0568	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
B6254_0569	ENOG4108ZSR	alkaline shock protein
B6254_0570	ENOG4105M7K	Involved in the transcription termination process (By similarity)
B6254_0571	ENOG4108UUX	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity)
B6254_0572	ENOG4105VJV	50s ribosomal protein L35
B6254_0573	ENOG4108YZX	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity)
B6254_0574	ENOG4105DIH	basic membrane
B6254_0576	ENOG4105CVG	Homoserine O-transsuccinylase
B6254_0577	ENOG4105C28	cystathionine
B6254_0578	ENOG4105D6E	homoserine dehydrogenase
B6254_0581	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
B6254_0582	ENOG4105C3U	ABC transporter
B6254_0583	ENOG4108JQ7	(ABC) transporter
B6254_0584	ENOG4108UKE	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity)
B6254_0585	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
B6254_0586	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
B6254_0588	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
B6254_0589	ENOG4105F38	ABC transporter, permease
B6254_0590	ENOG4105D38	putrescine abc transporter
B6254_0591	ENOG4108HM4	ABC transporter
B6254_0592	ENOG4108R5K	PPIases accelerate the folding of proteins (By similarity)
B6254_0594	ENOG4107YZX	Universal stress protein
B6254_0596	ENOG41086DT	Membrane protein of unknown function
B6254_0597	ENOG4105D1C	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity)
B6254_0603	ENOG4105C3M	thioredoxin reductase
B6254_0604	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
B6254_0606	ENOG4105KRI	phosphocarrier protein (HPr
B6254_0607	ENOG4105BZ3	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity)
B6254_0608	ENOG4105CP7	Triose-phosphate isomerase
B6254_0611	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
B6254_0612	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
B6254_0613	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
B6254_0615	ENOG4105C40	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity)
B6254_0616	ENOG4108UH4	Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity)
B6254_0618	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
B6254_0620	ENOG4105E5Q	amino acid AbC transporter
B6254_0621	ENOG4105CDA	abc transporter atp-binding protein
B6254_0622	ENOG41080TC	multidrug resistance protein
B6254_0623	ENOG410839T	multidrug resistance protein
B6254_0625	ENOG4105D5S	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity)
B6254_0626	ENOG4108IJ2	phosphate acetyltransferase
B6254_0627	ENOG4105K8N	protein family UPF0079, ATPase
B6254_0629	ENOG4105DE5	Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity)
B6254_0630	ENOG4105D4A	Cell wall formation (By similarity)
B6254_0631	ENOG4105EEQ	Na H antiporter
B6254_0633	ENOG4107U5W	ybbr family
B6254_0634	ENOG4107QJF	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity)
B6254_0638	ENOG4105CXT	aspartate transcarbamylase
B6254_0639	ENOG4105CD3	dihydroorotase
B6254_0640	ENOG4105C1M	carbamoyl-phosphate synthetase glutamine chain
B6254_0641	ENOG4105CU6	carbamoyl-phosphate synthetase ammonia chain
B6254_0642	ENOG4107RY0	Catalyzes the conversion of dihydroorotate to orotate (By similarity)
B6254_0643	ENOG4106EG9	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity)
B6254_0644	ENOG41065E1	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
B6254_0645	ENOG4105BZF	Glycosyl transferase (Group 1
B6254_0646	ENOG4105W2C	Glycosyl transferase
B6254_0649	ENOG4105E0M	Sulfatase
B6254_0661	ENOG41065RQ	ADP-ribosylation crystallin J1
B6254_0664	ENOG4105ETZ	PTS System
B6254_0665	ENOG4105F3R	pts system mannose fructose sorbose family iid
B6254_0667	ENOG4105DKJ	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
B6254_0669	ENOG4105ZT7	DNA-entry nuclease
B6254_0676	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
B6254_0677	ENOG4105BZA	Phosphoglycerate kinase
B6254_0678	ENOG4105C5Q	Transcriptional regulator
B6254_0680	ENOG4108UGX	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity)
B6254_0681	ENOG4108EKI	Dehydrogenase
B6254_0683	ENOG4105CV8	reductase
B6254_0685	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
B6254_0687	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
B6254_0750	ENOG4105CHR	reductase
B6254_0754	ENOG4105C85	amino acid
B6254_0755	ENOG4105CTD	carboxy-peptidase
B6254_0756	ENOG4105DFD	Na H antiporter
B6254_0757	ENOG4105VND	Ribonuclease
B6254_0759	ENOG4105C34	Pseudouridine synthase
B6254_0760	ENOG4108UK1	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity)
B6254_0761	ENOG4105C1M	carbamoyl-phosphate synthetase glutamine chain
B6254_0763	ENOG4107UUG	Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity)
B6254_0764	ENOG4105C83	adenylosuccinate lyase
B6254_0766	ENOG4108YXN	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity)
B6254_0767	ENOG41067TZ	transcriptional regulator, MarR family
B6254_0768	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
B6254_0769	ENOG4105VNB	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
B6254_0770	ENOG4105EA8	2-Nitropropane dioxygenase
B6254_0771	ENOG4105CJF	Malonyl coA-acyl carrier protein transacylase
B6254_0772	ENOG4105CHR	reductase
B6254_0773	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
B6254_0775	ENOG4108YXN	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity)
B6254_0776	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
B6254_0777	ENOG4107QTG	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity)
B6254_0779	ENOG4105E66	phosphoriboisomerase A
B6254_0783	ENOG4105KRQ	Addiction module toxin, Txe YoeB family
B6254_0785	ENOG4108V0P	LemA family
B6254_0788	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
B6254_0789	ENOG4105EE0	oxidoreductase
B6254_0790	ENOG4105FDU	atp-dependent rna helicase
B6254_0791	ENOG4105FF6	Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity)
B6254_0794	ENOG4108Z6X	(sortase) family
B6254_0795	ENOG41080S5	HTH_DTXR
B6254_0798	ENOG4105D5I	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity)
B6254_0799	ENOG4105ETE	Transcriptional regulator (LacI family
B6254_0801	ENOG4105CFH	Aspartokinase
B6254_0802	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
B6254_0805	ENOG4105CH2	amidohydrolase
B6254_0806	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
B6254_0807	ENOG4105DUK	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity)
B6254_0808	ENOG4105CHM	Aminotransferase
B6254_0809	ENOG4105CM3	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity)
B6254_0813	ENOG4105CHM	Aminotransferase
B6254_0817	ENOG4105E2X	shikimate dehydrogenase
B6254_0818	ENOG4108JPM	phospho-2-dehydro-3-deoxyheptonate aldolase
B6254_0819	ENOG4105D49	3-dehydroquinate synthase
B6254_0820	ENOG4105D10	5-enolpyruvylshikimate-3-phosphate phospholyase
B6254_0821	ENOG4105CMY	5-enolpyruvylshikimate-3-phosphate synthase
B6254_0822	ENOG4105KHV	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity)
B6254_0823	ENOG4105FF2	Type I DHQase
B6254_0826	ENOG4108JJB	ABC transporter
B6254_0827	ENOG4105NSK	ABC superfamily ATP binding cassette transporter membrane protein
B6254_0828	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
B6254_0829	ENOG4105CPC	Aldo Keto reductase
B6254_0833	ENOG4105C56	H( )-stimulated, divalent metal cation uptake system (By similarity)
B6254_0835	ENOG4105K7K	Transcriptional regulator
B6254_0838	ENOG4105GYP	Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity)
B6254_0839	ENOG4108KP7	hydrolase
B6254_0840	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
B6254_0841	ENOG4105VB5	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
B6254_0842	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
B6254_0843	ENOG4105CHT	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
B6254_0844	ENOG4105CBD	Diacylglycerol kinase
B6254_0846	ENOG4108XAN	ABC transporter
B6254_0847	ENOG4105CC5	ABC transporter
B6254_0848	ENOG4105DIK	(ABC) transporter
B6254_0851	ENOG4107EEN	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity)
B6254_0853	ENOG4105C75	arginyL-tRNA synthetase
B6254_0857	ENOG4105XBY	Regulates arginine biosynthesis genes (By similarity)
B6254_0858	ENOG4105BZ4	penicillin-binding protein
B6254_0859	ENOG4105WZB	UPF0342 protein
B6254_0861	ENOG4106D4I	domain protein
B6254_0863	ENOG4105CMG	Carbohydrate kinase
B6254_0865	ENOG4105C7K	acetolactate synthase
B6254_0871	ENOG4105BZQ	cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase
B6254_0873	ENOG4105CEV	competence damage-inducible protein
B6254_0874	ENOG4105C68	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)
B6254_0876	ENOG4105EEM	helicase
B6254_0877	ENOG4105CS9	pantothenic acid kinase
B6254_0882	ENOG4108YBP	pseudouridine synthase
B6254_0885	ENOG4105C88	aminopeptidase
B6254_0910	ENOG4105Z8B	NlpC/P60 family
B6254_0914	ENOG4105EYW	Ion transport protein
B6254_0918	ENOG4107SJB	teichoic acid biosynthesis
B6254_0920	ENOG4105KPE	licD family
B6254_0921	ENOG4108QHG	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity)
B6254_0922	ENOG4105EJJ	Dehydrogenase
B6254_0923	ENOG4105EY8	ABC transporter
B6254_0928	ENOG4107YSK	Glycerol-3-phosphate cytidylyltransferase
B6254_0935	ENOG4108IYT	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
B6254_0938	ENOG4108IMY	Transcriptional regulator
B6254_0948	ENOG4108UUM	single-stranded DNA-binding protein
B6254_0987	ENOG4105CA1	Removes the N-terminal methionine from nascent proteins (By similarity)
B6254_0988	ENOG4105D3Q	Sugar transferase
B6254_0993	ENOG4105D5D	udp-galactopyranose mutase
B6254_0996	ENOG4108ZW7	flagellar rod assembly protein muramidase flgj
B6254_0998	ENOG4105CKK	Glycosyl transferase, family 2
B6254_1000	ENOG4108RJ9	Glycosyl transferase, family 2
B6254_1006	ENOG4105CI8	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity)
B6254_1007	ENOG4105K90	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
B6254_1008	ENOG4105CFG	Acts as a chaperone (By similarity)
B6254_1009	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
B6254_1013	ENOG4105C2R	Single-stranded-DNA-specific exonuclease (RecJ)
B6254_1014	ENOG4109003	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity)
B6254_1017	ENOG4105DS7	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity)
B6254_1018	ENOG4105VPS	UPF0291 protein
B6254_1019	ENOG4105VXM	UPF0154 protein
B6254_1022	ENOG4105Z8B	NlpC/P60 family
B6254_1023	ENOG4105F6E	Acyl-transferase
B6254_1024	ENOG41060K3	Methyltransferase
B6254_1025	ENOG4105VC4	domain protein
B6254_1026	ENOG4105CE9	30S ribosomal protein S2
B6254_1027	ENOG4105CU7	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity)
B6254_1028	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
B6254_1029	ENOG4108VCV	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity)
B6254_1030	ENOG4108RB3	Capsular polysaccharide biosynthesis protein
B6254_1032	ENOG4107YJ4	chain length determinant protein
B6254_1033	ENOG4105D3Q	Sugar transferase
B6254_1034	ENOG4108PQP	glycosyl transferase group 1
B6254_1036	ENOG4107QRS	glycosyltransferase group 2 family protein
B6254_1039	ENOG4105K64	Glycosyl transferase, family 2
B6254_1040	ENOG4108KGH	TRANSCRIPTIONal
B6254_1043	ENOG4105BZU	Histidine kinase
B6254_1044	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
B6254_1048	ENOG4105D4J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
B6254_1049	ENOG4105C5H	ABC transporter
B6254_1050	ENOG4108YYV	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity)
B6254_1052	ENOG4105C0B	DNA polymerase III (alpha subunit)
B6254_1053	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
B6254_1054	ENOG4108YYA	Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity)
B6254_1056	ENOG4107RWR	Sodium hydrogen exchanger
B6254_1058	ENOG4105QNR	S1 RNA binding domain protein
B6254_1061	ENOG4108KVX	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity)
B6254_1062	ENOG4105K8I	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity)
B6254_1063	ENOG4105FE9	pseudouridine synthase
B6254_1066	ENOG4108SAX	Membrane
B6254_1068	ENOG4105C9U	ATP-dependent DNA helicase RecQ
B6254_1070	ENOG4105CAT	Cytidine monophosphate kinase
B6254_1071	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
B6254_1072	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
B6254_1074	ENOG4105DWF	phosphomethylpyrimidine kinase
B6254_1075	ENOG4105PUK	Membrane
B6254_1076	ENOG4105DJ2	Major Facilitator Superfamily
B6254_1079	ENOG4105EYH	Exonuclease
B6254_1088	ENOG41068YB	TPR repeat-containing protein
B6254_1089	ENOG4106943	Heat shock protein
B6254_1091	ENOG4105EGD	dinuclear metal center protein, YbgI family
B6254_1093	ENOG4105C6H	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity)
B6254_1098	ENOG41082QR	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
B6254_1102	ENOG4105I2S	Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity)
B6254_1103	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
B6254_1106	ENOG4105DC8	reductase
B6254_1108	ENOG4105C6K	Malic enzyme
B6254_1109	ENOG4107ZGM	malolactic fermentation system
B6254_1110	ENOG4105EMU	Dehydrogenase
B6254_1111	ENOG4107QTZ	amino acid
B6254_1113	ENOG410807C	QueT transporter
B6254_1117	ENOG4105IKJ	beta-galactosidase small subunit
B6254_1119	ENOG4107QNK	)-transporter
B6254_1120	ENOG4107QNK	)-transporter
B6254_1121	ENOG4106KNP	GTP-binding protein LepA C-terminus
B6254_1123	ENOG4107R7I	amino acid
B6254_1127	ENOG4105CS2	ec 3.2.1.21
B6254_1129	ENOG4108XXK	NUDIX hydrolase
B6254_1131	ENOG4105CJ3	phosphate transporter
B6254_1132	ENOG4105EE6	Alcohol dehydrogenase zinc-binding domain protein
B6254_1135	ENOG4105DM4	PTS System
B6254_1136	ENOG4105DE4	1-phosphofructokinase
B6254_1137	ENOG4105E98	transcriptional regulator DeoR family
B6254_1138	ENOG4105GP2	5'(3')-deoxyribonucleotidase
B6254_1139	ENOG4107QMW	pyridine nucleotide-disulfide oxidoreductase
B6254_1144	ENOG41065RQ	ADP-ribosylation crystallin J1
B6254_1146	ENOG4105CZ1	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity)
B6254_1149	ENOG4105K59	histidine triad (HIT) protein
B6254_1151	ENOG4107VKM	6-phosphogluconolactonase
B6254_1152	ENOG4105DUX	Transporter
B6254_1153	ENOG4107QM9	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity)
B6254_1154	ENOG4107QTG	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity)
B6254_1155	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
B6254_1157	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
B6254_1161	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
B6254_1162	ENOG4105C4R	Atp-dependent dna helicase
B6254_1163	ENOG4105C4H	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity)
B6254_1164	ENOG4105XWG	Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation (By similarity)
B6254_1165	ENOG4108UKS	UPF0398 protein
B6254_1166	ENOG4108UI2	Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity)
B6254_1189	ENOG4105K5M	30s ribosomal protein S16
B6254_1217	ENOG4108PNI	recT protein
B6254_1231	ENOG4105VTR	Integrase
B6254_1232	ENOG4105C5S	asparaginyl-tRNA synthetase
B6254_1234	ENOG4105DVT	helicase
B6254_1238	ENOG4106UJV	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity)
B6254_1240	ENOG4108JYZ	YitT family
B6254_1241	ENOG4105H9W	Short-chain dehydrogenase reductase Sdr
B6254_1242	ENOG4107XQC	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins (By similarity)
B6254_1245	ENOG4107SC7	Inner membrane transporter yjeM
B6254_1247	ENOG4107X35	defense response to bacterium
B6254_1249	ENOG4105GR3	Histidine kinase
B6254_1250	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
B6254_1255	ENOG4108ZQD	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity)
B6254_1256	ENOG4105ERD	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity)
B6254_1257	ENOG4105C2M	dna polymerase I
B6254_1258	ENOG4105HFZ	Membrane
B6254_1259	ENOG4105DFU	Cell wall formation (By similarity)
B6254_1261	ENOG4108VDD	TRNA binding domain protein
B6254_1262	ENOG4105CN9	Peptidase m42 family protein
B6254_1263	ENOG4105DBI	uridine monophosphokinase
B6254_1264	ENOG4105BZU	Histidine kinase
B6254_1265	ENOG4105DPZ	Two component transcriptional regulator (Winged helix family
B6254_1271	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
B6254_1272	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
B6254_1278	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
B6254_1283	ENOG4105E4C	Lytic transglycosylase catalytic
B6254_1289	ENOG41089N3	Inherit from COG: cobyrinic Acid a,c-diamide synthase
B6254_1294	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
B6254_1316	ENOG4107PP3	Acetylornithine deacetylase
B6254_1320	ENOG4105CVJ	phosphoglycerate mutase
B6254_1321	ENOG4105ETT	transcriptional Regulator, LysR family
B6254_1327	ENOG4105CQ3	Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity)
B6254_1328	ENOG4105CQ3	Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity)
B6254_1340	ENOG41080HJ	6-phospho 3-hexuloisomerase
B6254_1341	ENOG4108VA3	3-hexulose-6-phosphate synthase
B6254_1343	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
B6254_1344	ENOG41063PX	domain protein
B6254_1345	ENOG4108ZEF	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)
B6254_1346	ENOG4106H78	methyltransferase
B6254_1347	ENOG4105WUC	UPF0298 protein
B6254_1348	ENOG4105CNI	cell division protein FtsW
B6254_1349	ENOG4105CI3	gtp-binding protein typa
B6254_1350	ENOG4105ECY	inositol monophosphatase
B6254_1351	ENOG4105WBI	UPF0223 protein
B6254_1352	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
B6254_1361	ENOG4108HW8	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity)
B6254_1362	ENOG4105D01	(LipO)protein
B6254_1363	ENOG4107QMW	pyridine nucleotide-disulfide oxidoreductase
B6254_1366	ENOG4108IJ7	Glycine betaine
B6254_1369	ENOG4105E2M	Manganese-dependent inorganic pyrophosphatase
B6254_1370	ENOG4105K7Z	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity)
B6254_1372	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
B6254_1373	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
B6254_1374	ENOG4105C79	DNA protecting protein DprA
B6254_1375	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
B6254_1376	ENOG4105C9W	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity)
B6254_1377	ENOG4105VSD	UPF0346 protein
B6254_1379	ENOG41090WU	lipolytic protein G-D-S-L family
B6254_1380	ENOG4108RCR	degv family
B6254_1381	ENOG4105EPR	degv family
B6254_1382	ENOG4105DEU	major facilitator superfamily
B6254_1385	ENOG4106N3A	copper homeostasis protein cutc
B6254_1386	ENOG4105F23	Fibronectin-binding protein
B6254_1387	ENOG4105DTN	riboflavin biosynthesis protein ribF
B6254_1389	ENOG4105CEP	NADH dehydrogenase
B6254_1390	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
B6254_1391	ENOG4105KG7	Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity)
B6254_1392	ENOG4107QHU	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
B6254_1394	ENOG4105VZN	Nucleic-acid-binding protein implicated in transcription termination
B6254_1395	ENOG4105CHV	Transcription elongation factor NusA
B6254_1396	ENOG4105K7D	Required for maturation of 30S ribosomal subunits (By similarity)
B6254_1405	ENOG4105D10	5-enolpyruvylshikimate-3-phosphate phospholyase
B6254_1406	ENOG4105EMV	Major Facilitator
B6254_1407	ENOG4105KHV	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity)
B6254_1408	ENOG4105EVN	Prephenate dehydrogenase
B6254_1409	ENOG4105CMY	5-enolpyruvylshikimate-3-phosphate synthase
B6254_1412	ENOG4105C5Y	PTS System
B6254_1414	ENOG4105JAB	phenazine biosynthesis protein, phzf family
B6254_1419	ENOG41090U3	tautomerase
B6254_1422	ENOG4105F03	Provides the (R)-glutamate required for cell wall biosynthesis (By similarity)
B6254_1435	ENOG4105PGM	cation diffusion facilitator family transporter
B6254_1438	ENOG41090PH	Protease synthase and sporulation negative regulatory protein pai 1
B6254_1439	ENOG4108U05	Transcriptional regulator
B6254_1441	ENOG4108UWZ	4-Carboxymuconolactone decarboxylase
B6254_1444	ENOG4108W5M	transcriptional regulator
B6254_1445	ENOG4108J59	Extracellular solute-binding protein, family 5
B6254_1455	ENOG4105C2C	drug resistance transporter, Bcr CflA
B6254_1456	ENOG4105CJW	magnesium transporter
B6254_1457	ENOG4105EMS	pseudouridine synthase
B6254_1458	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
B6254_1466	ENOG4108V82	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
B6254_1467	ENOG4105F03	Provides the (R)-glutamate required for cell wall biosynthesis (By similarity)
B6254_1484	ENOG4105EVU	fructokinase
B6254_1491	ENOG4108UV6	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity)
B6254_1492	ENOG4105DWF	phosphomethylpyrimidine kinase
B6254_1493	ENOG4105C4U	4-methyl-5-beta-hydroxyethylthiazole kinase
B6254_1496	ENOG4105D01	(LipO)protein
B6254_1497	ENOG4105D01	(LipO)protein
B6254_1499	ENOG4105CHM	Aminotransferase
B6254_1500	ENOG4105CQB	FAD linked oxidase domain protein
B6254_1517	ENOG4108JJB	ABC transporter
B6254_1518	ENOG4108V7D	UPF0397 protein
B6254_1520	ENOG4108JA1	polyketide synthase
B6254_1521	ENOG4105C9X	ppx gppa phosphatase
B6254_1522	ENOG4105CUU	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity)
B6254_1523	ENOG4105CQB	FAD linked oxidase domain protein
B6254_1525	ENOG4105C7K	acetolactate synthase
B6254_1533	ENOG4107DB1	DUF218 domain
B6254_1538	ENOG4107QUV	Domain protein
B6254_1542	ENOG4107FQX	Alpha-acetolactate decarboxylase
B6254_1543	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
B6254_1544	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
B6254_1545	ENOG4105K63	Thioredoxin
B6254_1549	ENOG4105C98	muts2 protein
B6254_1553	ENOG4105WHM	Necessary for normal cell division and for the maintenance of normal septation (By similarity)
B6254_1554	ENOG4105CHN	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
B6254_1557	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
B6254_1560	ENOG4105KQV	Binds directly to 16S ribosomal RNA (By similarity)
B6254_1561	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
B6254_1562	ENOG4105TQK	DNA polymerase iii, delta' subunit
B6254_1563	ENOG4108EQH	DNA internalization-related competence protein ComEC Rec2
B6254_1565	ENOG4105VPH	UPF0473 protein
B6254_1566	ENOG4105VPH	UPF0473 protein
B6254_1567	ENOG4108Z08	Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity)
B6254_1568	ENOG4105VBH	UPF0297 protein
B6254_1569	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
B6254_1570	ENOG4105BZW	Glycerate kinase
B6254_1571	ENOG4105C1J	atp-dependent rna helicase
B6254_1572	ENOG4105SFS	phosphoesterase RecJ domain protein
B6254_1573	ENOG4105CQ3	Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity)
B6254_1574	ENOG4105VIE	preprotein translocase, subunit YajC
B6254_1575	ENOG4105C6U	Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity)
B6254_1582	ENOG4105E2N	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity)
B6254_1583	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
B6254_1584	ENOG4105KA4	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity)
B6254_1585	ENOG4105CPN	adenine deaminase
B6254_1586	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
B6254_1587	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
B6254_1590	ENOG4108ZK7	protein family UPF0029, Impact, N-terminal protein
B6254_1591	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
B6254_1592	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
B6254_1595	ENOG4105RHA	ABC transporter, permease
B6254_1596	ENOG4108IUX	(ABC) transporter
B6254_1598	ENOG4105CNU	cell division protein FtsK
B6254_1599	ENOG4108UIQ	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity)
B6254_1601	ENOG4105HHQ	6-phosphogluconolactonase (EC 3.1.1.31)
B6254_1603	ENOG4105DU1	integral membrane protein, terc
B6254_1605	ENOG4105C38	Glycyl-tRNA synthetase beta subunit
B6254_1606	ENOG4108HMW	glycyl-tRNA synthetase, alpha subunit
B6254_1610	ENOG4105CWT	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity)
B6254_1612	ENOG4105KGE	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity)
B6254_1613	ENOG4105C9A	Phoh family
B6254_1614	ENOG4105KTH	gatB Yqey
B6254_1615	ENOG4105VCC	30S ribosomal protein S21
B6254_1616	ENOG4107AYK	membrAne
B6254_1618	ENOG4105C9M	aspartyl-trna synthetase
B6254_1619	ENOG4105CUT	histidyl-tRNA synthetase
B6254_1620	ENOG4105C5C	n-acetylmuramoyl-l-alanine amidase
B6254_1623	ENOG4105F99	Hydroxymethylglutaryl-CoA synthase
B6254_1624	ENOG4105CJS	Phosphopantothenoylcysteine decarboxylase
B6254_1638	ENOG4105DC7	peptidase M24
B6254_1639	ENOG4105ETE	Transcriptional regulator (LacI family
B6254_1642	ENOG4105D8C	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity)
B6254_1643	ENOG4105DPN	Oligoendopeptidase f
B6254_1645	ENOG4105CK1	PTS System
B6254_1646	ENOG4105CS2	ec 3.2.1.21
B6254_1647	ENOG4105VCP	PTS System
B6254_1648	ENOG4105VZJ	PTS System
B6254_1649	ENOG4105CS2	ec 3.2.1.21
B6254_1650	ENOG4108SQ7	Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis
B6254_1651	ENOG41090SU	Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity)
B6254_1652	ENOG4105CDW	Resistance protein
B6254_1666	ENOG410667J	hydrolase
B6254_1667	ENOG4105M2E	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity)
B6254_1668	ENOG4105ZMH	deoxynucleoside kinase
B6254_1671	ENOG41069HH	4-oxalocrotonate tautomerase
B6254_1672	ENOG4107AYK	membrAne
B6254_1674	ENOG4108YY1	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity)
B6254_1675	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
B6254_1676	ENOG4107Z8R	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity)
B6254_1677	ENOG4105DKJ	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
B6254_1680	ENOG4105DU1	integral membrane protein, terc
B6254_1681	ENOG4105K5M	30s ribosomal protein S16
B6254_1685	ENOG4105CB9	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
B6254_1687	ENOG4105CCP	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
B6254_1688	ENOG4105CDB	Required for chromosome condensation and partitioning (By similarity)
B6254_1689	ENOG4108ZBM	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity)
B6254_1690	ENOG4105VNB	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
B6254_1691	ENOG4105C6B	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity)
B6254_1692	ENOG4105CB5	ATP-dependent DNA helicase recG
B6254_1694	ENOG4108NMT	An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon (By similarity)
B6254_1697	ENOG4105DP4	dak2 domain fusion protein ylov
B6254_1699	ENOG4105VB9	50S ribosomal protein l28
B6254_1701	ENOG4105DJV	ribulose-phosphate 3-epimerase
B6254_1702	ENOG4105E06	May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity)
B6254_1703	ENOG4105D9P	serine threonine protein kinase
B6254_1704	ENOG4108ZF3	Phosphatase
B6254_1705	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
B6254_1706	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
B6254_1707	ENOG4105C25	Primosomal protein n'
B6254_1708	ENOG4105C6H	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity)
B6254_1717	ENOG4105C7N	Xanthine uracil vitamin C permease
B6254_1718	ENOG4105CDY	transcriptional regulatory protein
B6254_1719	ENOG4105C7H	Helicase, RecD TraA family
B6254_1726	ENOG4105VR5	Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity)
B6254_1728	ENOG4105CIT	This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity)
B6254_1729	ENOG41087KY	Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity)
B6254_1730	ENOG4105DVQ	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity)
B6254_1731	ENOG4105DMZ	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity)
B6254_1732	ENOG4105CPY	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity)
B6254_1733	ENOG4105CJN	penicillin-binding protein
B6254_1735	ENOG4105CGJ	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity)
B6254_1736	ENOG4108V6E	Cell division protein mraZ
B6254_1738	ENOG4107TVK	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity)
B6254_1739	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
B6254_1740	ENOG4105CA9	Pyruvate kinase
B6254_1742	ENOG4108IQI	permease
B6254_1746	ENOG4107QMW	pyridine nucleotide-disulfide oxidoreductase
B6254_1749	ENOG4105CKU	formyltetrahydrofolate synthetase
B6254_1750	ENOG4105C12	Phosphoribosylglycinamide synthetase
B6254_1751	ENOG4105DC1	bifunctional purine biosynthesis protein purh
B6254_1752	ENOG4108V3E	phosphoribosylglycinamide formyltransferase
B6254_1753	ENOG4105CXB	phosphoribosylaminoimidazole synthetase
B6254_1755	ENOG4108JIU	phosphoribosylformylglycinamidine synthase ii
B6254_1756	ENOG4105D21	Phosphoribosylformylglycinamidine synthase I
B6254_1757	ENOG410839H	phosphoribosylformylglycinamidine synthase
B6254_1758	ENOG4105C8V	SAICAR synthetase
B6254_1759	ENOG4105CY8	phosphoribosylaminoimidazole carboxylase atpase subunit
B6254_1760	ENOG4108UM6	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity)
B6254_1761	ENOG4105C66	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity)
B6254_1762	ENOG4105EAB	amino acid AbC transporter
B6254_1763	ENOG4105CDA	abc transporter atp-binding protein
B6254_1764	ENOG4105E5Q	amino acid AbC transporter
B6254_1766	ENOG4108UHE	carbonic anhydrase
B6254_1767	ENOG4105N3I	Involved in formation and maintenance of cell shape (By similarity)
B6254_1768	ENOG4105DFF	Rod shape-determining protein mreb
B6254_1769	ENOG4105W5Q	DNA repair protein (RadC
B6254_1772	ENOG4105CI1	PTS System
B6254_1773	ENOG4105EPR	degv family
B6254_1774	ENOG4106A8V	Protein CrcB homolog
B6254_1775	ENOG41087RV	Protein CrcB homolog
B6254_1776	ENOG4105CMQ	Chloride channel
B6254_1777	ENOG4108JJB	ABC transporter
B6254_1778	ENOG4105C7J	ABC transporter, permease
B6254_1780	ENOG4105E05	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
B6254_1781	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
B6254_1788	ENOG4105FBA	Phospholipase Carboxylesterase
B6254_1790	ENOG4105DUF	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity)
B6254_1792	ENOG4108YZ4	nudix hydrolase
B6254_1796	ENOG4108HH9	Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR
B6254_1798	ENOG4108JJ8	(ABC) transporter
B6254_1799	ENOG4108JJ9	ABC, transporter
B6254_1800	ENOG4105CFY	cytochrome d ubiquinol oxidase, subunit ii
B6254_1801	ENOG4105C4M	(Ubiquinol oxidase) subunit I
B6254_1826	ENOG4108R5K	PPIases accelerate the folding of proteins (By similarity)
B6254_1827	ENOG4105DQR	SNARE associated Golgi
B6254_1828	ENOG4105ZAD	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity)
B6254_1829	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
B6254_1831	ENOG4105C4F	May be involved in recombinational repair of damaged DNA (By similarity)
B6254_1832	ENOG4105XBY	Regulates arginine biosynthesis genes (By similarity)
B6254_1833	ENOG4105DX0	Hemolysin A
B6254_1834	ENOG4105CTB	Polyprenyl synthetase
B6254_1835	ENOG41067QG	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
B6254_1836	ENOG4105DVS	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
B6254_1837	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
B6254_1838	ENOG4108V7D	UPF0397 protein
B6254_1842	ENOG4107WD8	ABC transporter, permease
B6254_1844	ENOG4105K70	DNA-binding protein
B6254_1845	ENOG4105CKA	Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity)
B6254_1846	ENOG4108Z6X	(sortase) family
B6254_1847	ENOG4105C22	threonyL-tRNA synthetase
B6254_1867	ENOG4105DC6	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity)
B6254_1868	ENOG4105D86	that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity)
B6254_1870	ENOG4105CDE	UPF0348 protein
B6254_1871	ENOG4105DXX	methyltransferase
B6254_1873	ENOG4108WF2	Metal Dependent Phosphohydrolase
B6254_1874	ENOG4108Z1W	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity)
B6254_1876	ENOG4105CQW	ribosome biogenesis GTPase YqeH
B6254_1877	ENOG4108WJV	had superfamily (subfamily IIIa) phosphatase
B6254_1880	ENOG4105C0X	amino acid
B6254_1881	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
B6254_1882	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
B6254_1883	ENOG4105C5H	ABC transporter
B6254_1886	ENOG4107XU6	Glycosyl transferase (Group 1
B6254_1887	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
B6254_1889	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
B6254_1895	ENOG4108UT2	hemolysin iii
B6254_1919	ENOG4105D1H	recombination factor protein RarA
B6254_1924	ENOG4105C8A	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity)
B6254_1929	ENOG410902V	Modulates RecA activity (By similarity)
B6254_1930	ENOG4108UTW	Plays a role in the regulation of phosphate uptake
B6254_1931	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
B6254_1932	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
B6254_1933	ENOG4105E2Z	phosphate ABC transporter (Permease
B6254_1934	ENOG4105C8U	phosphate abc transporter
B6254_1935	ENOG4105CVA	phosphate
B6254_1940	ENOG4105D9R	oxidoreductase
B6254_1941	ENOG4108J59	Extracellular solute-binding protein, family 5
B6254_1942	ENOG4105D4U	had-superfamily hydrolase, subfamily iia
B6254_1943	ENOG4105MMD	transcriptional regulator
B6254_1944	ENOG4107R8B	5'-nucleotidase
B6254_1948	ENOG4105DTQ	mandelate racemase muconate lactonizing
B6254_1949	ENOG4107J5P	Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity)
B6254_1950	ENOG4105C4A	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity)
B6254_1951	ENOG4105E4F	Isochorismate synthase
B6254_1952	ENOG4108DBC	nitroreductase
B6254_1953	ENOG4105BZ1	(ABC) transporter
B6254_1963	ENOG4105K46	50S ribosomal protein l27
B6254_1969	ENOG4105C5F	glutamine synthetase
B6254_1970	ENOG4105KV4	Transcriptional regulator
B6254_1971	ENOG4105DKX	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)
B6254_1972	ENOG4108QXE	glycerophosphoryl diester phosphodiesterase
B6254_1976	ENOG41068JE	domain protein
B6254_1981	ENOG4105MK2	5-formyltetrahydrofolate cyclo-ligase
B6254_1982	ENOG4107RF6	penicillin-binding protein
B6254_1984	ENOG4108UKH	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
B6254_1985	ENOG4105C9U	ATP-dependent DNA helicase RecQ
B6254_1987	ENOG4105C6A	phenylalanyl-tRNA synthetase (beta subunit)
B6254_1988	ENOG4105CSS	phenylalanyl-tRNA synthetase (alpha subunit)
B6254_1992	ENOG4108RWN	rrna methyltransferase
B6254_1996	ENOG4105CG1	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity)
B6254_1997	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
B6254_1998	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
B6254_1999	ENOG4105CTP	PilT protein domain protein
B6254_2001	ENOG4107Z0P	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity)
B6254_2004	ENOG41068JE	domain protein
B6254_2006	ENOG4107FQX	Alpha-acetolactate decarboxylase
B6254_2008	ENOG4105C80	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
B6254_2009	ENOG4108TKW	Glyoxalase Bleomycin resistance protein (Dioxygenase
B6254_2021	ENOG4108IYT	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
B6254_2025	ENOG4105C56	H( )-stimulated, divalent metal cation uptake system (By similarity)
B6254_2026	ENOG41086FC	50S ribosomal protein l32
B6254_2027	ENOG4105C5Y	PTS System
B6254_2030	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
B6254_2031	ENOG4105CIE	May be required for sporulation (By similarity)
B6254_2032	ENOG4105CHW	UPF0052 protein
B6254_2035	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
B6254_2036	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
B6254_2038	ENOG410841Q	phosphoesterase PA-phosphatase related protein
B6254_2040	ENOG4105CG3	alpha amylase, catalytic region
B6254_2043	ENOG4108RG0	uracil-dna glycosylase
B6254_2046	ENOG4105C7K	acetolactate synthase
B6254_2050	ENOG4108UJD	30S ribosomal protein S9
B6254_2051	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
B6254_2052	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
B6254_2054	ENOG4108JJB	ABC transporter
B6254_2055	ENOG4108JJB	ABC transporter
B6254_2058	ENOG4105DSE	periplasmic solute binding protein
B6254_2059	ENOG4105CC5	ABC transporter
B6254_2060	ENOG4105DIK	(ABC) transporter
B6254_2062	ENOG4105KBC	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
B6254_2063	ENOG4108VZM	50s ribosomal protein L10
B6254_2064	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
B6254_2065	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
B6254_2066	ENOG4105E5V	Participates in transcription elongation, termination and antitermination (By similarity)
B6254_2067	ENOG410683Z	Preprotein translocase SecE subunit
B6254_2069	ENOG4105C2N	RNA methyltransferase TrmH family group 3
B6254_2070	ENOG4105KEB	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
B6254_2071	ENOG4106762	Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity)
B6254_2072	ENOG4105D01	(LipO)protein
B6254_2074	ENOG4105C28	cystathionine
B6254_2075	ENOG4105C8N	cysteinyl-tRNA synthetase
B6254_2076	ENOG4108JIJ	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity)
B6254_2077	ENOG4105C80	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
B6254_2078	ENOG4107QPK	)-transporter
B6254_2079	ENOG4107EFR	Flavocytochrome c
B6254_2080	ENOG4105C9Q	fumarate hydratase class II
B6254_2081	ENOG4107RSM	transcriptional regulator
B6254_2085	ENOG4107RA1	nh(3)-dependent nad( ) synthetase
B6254_2086	ENOG4105DAP	Nicotinate phosphoribosyltransferase
B6254_2088	ENOG4105D01	(LipO)protein
B6254_2089	ENOG4108JEI	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity)
B6254_2090	ENOG4108UMI	ABC transporter, permease
B6254_2094	ENOG4108ZT0	50S ribosomal protein l17
B6254_2095	ENOG4105CTF	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
B6254_2096	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
B6254_2097	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
B6254_2098	ENOG41067V7	50S ribosomal protein L36
B6254_2099	ENOG4105K9U	however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)
B6254_2101	ENOG4105CGG	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity)
B6254_2102	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
B6254_2104	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
B6254_2106	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
B6254_2107	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
B6254_2108	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
B6254_2109	ENOG4105KAR	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity)
B6254_2110	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
B6254_2111	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
B6254_2112	ENOG41082SA	50s ribosomal protein l29
B6254_2114	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
B6254_2115	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
B6254_2117	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
B6254_2118	ENOG41080UE	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
B6254_2119	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
B6254_2120	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
B6254_2121	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
B6254_2125	ENOG4105KEG	ribosomal-protein-alanine acetyltransferase
B6254_2126	ENOG41072GX	Peptidase M22 Glycoprotease
B6254_2127	ENOG4105CMR	udp-glucose 4-epimerase
B6254_2131	ENOG4105X0R	protein from nitrogen regulatory protein P-II
B6254_2132	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
B6254_2135	ENOG4105F3K	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity)
B6254_2137	ENOG4105C6E	dna polymerase iii
B6254_2138	ENOG4108Z6B	deaminase
B6254_2139	ENOG4107Y49	methyltransferase
B6254_2140	ENOG4108URH	decarboxylase
B6254_2141	ENOG4105DJ2	Major Facilitator Superfamily
B6254_2143	ENOG41067QW	Transcriptional regulator
B6254_2151	ENOG4105DHI	Methyltransferase
B6254_2152	ENOG4107Z3H	Transcriptional regulator, TetR family
B6254_2158	ENOG4107QW4	alcohol dehydrogenase
B6254_2161	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
B6254_2162	ENOG4108IIJ	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
B6254_2164	ENOG4105KEX	transcriptional regulator, ctsr
B6254_2169	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
B6254_2170	ENOG4105ZMH	deoxynucleoside kinase
B6254_2172	ENOG4105KNM	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
B6254_2173	ENOG4105C4J	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
B6254_2174	ENOG4105J80	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity)
B6254_2175	ENOG4105CDG	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity)
B6254_2176	ENOG4107YZM	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
B6254_2177	ENOG4107ZFM	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity)
B6254_2178	ENOG4105WS6	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
B6254_2179	ENOG4107RFS	it plays a direct role in the translocation of protons across the membrane (By similarity)
B6254_2182	ENOG4105CGD	Nad-dependent epimerase dehydratase
B6254_2183	ENOG4105CZ5	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity)
B6254_2184	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
B6254_2185	ENOG4105EK0	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
B6254_2186	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
B6254_2187	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
B6254_2188	ENOG4107104	thymidine kinase
B6254_2190	ENOG4105F1K	Glutamine amidotransferase
B6254_2191	ENOG4105DMS	mur ligase
B6254_2192	ENOG4105DG6	mannose-6-phosphate isomerase
B6254_2194	ENOG4108UW5	maltose o-acetyltransferase
B6254_2199	ENOG4105BZ1	(ABC) transporter
B6254_2200	ENOG4105BZ1	(ABC) transporter
B6254_2203	ENOG4105C1N	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity)
B6254_2204	ENOG4105DKJ	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
B6254_2208	ENOG4105CGK	Exodeoxyribonuclease III
B6254_2209	ENOG4105E4P	ATPase (AAA
B6254_2211	ENOG4108EKI	Dehydrogenase
B6254_2213	ENOG4105C9K	Endothelin-converting enzyme 1
B6254_2224	ENOG4107YSK	Glycerol-3-phosphate cytidylyltransferase
B6254_2229	ENOG4108PQP	glycosyl transferase group 1
B6254_2236	ENOG4107QRS	glycosyltransferase group 2 family protein
B6254_2237	ENOG4107QRI	Phosphoketolase
B6254_2238	ENOG4108TZY	GntR Family Transcriptional Regulator
B6254_2239	ENOG4105D3Q	Sugar transferase
B6254_2244	ENOG4105EAG	UDP-N-acetylglucosamine 2-epimerase
B6254_2245	ENOG4105K2Z	endo-1,4-d-glucanase (EC 3.2.1.4)
B6254_2246	ENOG4107R8N	Glycosyl transferase, family 2
B6254_2253	ENOG4105EAD	ABC transporter
B6254_2255	ENOG4107QNK	)-transporter
B6254_2259	ENOG4105CAC	Catalyzes the conversion of L-arabinose to L-ribulose (By similarity)
B6254_2263	ENOG4105CUK	Alpha-N-arabinofuranosidase (EC 3.2.1.55)
B6254_2266	ENOG4107R73	Mate efflux family protein
B6254_2267	ENOG4105C5H	ABC transporter
B6254_2268	ENOG4105E4P	ATPase (AAA
B6254_2269	ENOG4105FAV	ABC, transporter
B6254_2270	ENOG4105FDK	ABC transporter
B6254_2272	ENOG41067TZ	transcriptional regulator, MarR family
B6254_2273	ENOG4105EXC	Acyl-transferase
B6254_2274	ENOG410906U	SprT-like
B6254_2281	ENOG4107QNK	)-transporter
B6254_2282	ENOG4105EVU	fructokinase
B6254_2283	ENOG4105CSC	Glucose uptake protein
B6254_2285	ENOG4105DUX	Transporter
B6254_2297	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
B6254_2299	ENOG4105C3G	gtp-binding protein
B6254_2300	ENOG4105VDK	protein, conserved in bacteria
B6254_2301	ENOG4105FA0	parb-like partition protein
B6254_2302	ENOG4107QJE	Chromosome Partitioning Protein
B6254_2305	ENOG4105CEN	a g-specific adenine glycosylase
B6254_2306	ENOG4105E66	phosphoriboisomerase A
B6254_2314	ENOG4105US7	Histidine kinase
B6254_2315	ENOG4108STX	response regulator
B6254_2319	ENOG4105CEY	Amp-dependent synthetase and ligase
B6254_2320	ENOG4108IPT	Naphthoate synthase
B6254_2321	ENOG4105KA0	thioesterase Superfamily protein
B6254_2323	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
B6254_2325	ENOG4105VEM	Conserved domain protein
B6254_2326	ENOG4105HDK	L-asparaginase
B6254_2327	ENOG4105CUB	amino acid
B6254_2329	ENOG4107R7I	amino acid
B6254_2332	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
B6254_2334	ENOG4105CPQ	Dehydrogenase
B6254_2335	ENOG4108W5N	phosphatidylglycerophosphatase a
B6254_2337	ENOG4107T66	Releases the N-terminal proline from various substrates (By similarity)
B6254_2338	ENOG4108J59	Extracellular solute-binding protein, family 5
B6254_2339	ENOG4105D8C	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity)
B6254_2341	ENOG4107U9W	Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S- specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX (By similarity)
B6254_2343	ENOG4105CQ3	Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity)
B6254_2345	ENOG4108VY7	phosphate-starvation-inducible protein PsiE
B6254_2347	ENOG4105CUB	amino acid
B6254_2351	ENOG4105EA8	2-Nitropropane dioxygenase
B6254_2352	ENOG4108IIG	CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity)
B6254_2353	ENOG4108KB2	LysR family Transcriptional regulator
B6254_2355	ENOG4105HMI	Membrane
B6254_2358	ENOG4105HMI	Membrane
B6254_2360	ENOG4108RTV	Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity)
B6254_2366	ENOG4105C85	amino acid
B6254_2371	ENOG4105KVH	Transcriptional regulator
B6254_2372	ENOG4105C02	permease
B6254_2376	ENOG410855V	Acylphosphatase
B6254_2377	ENOG4105EAB	amino acid AbC transporter
B6254_2380	ENOG4105E5Q	amino acid AbC transporter
B6254_2381	ENOG4105CDA	abc transporter atp-binding protein
B6254_2383	ENOG4105CZV	ABC transporter
B6254_2385	ENOG4105C4B	ABC transporter, permease
B6254_2386	ENOG41083J0	(ABC) transporter
B6254_2390	ENOG4105BZ1	(ABC) transporter
B6254_2391	ENOG41067TZ	transcriptional regulator, MarR family
B6254_2395	ENOG4105DIH	basic membrane
B6254_2396	ENOG4108UZ3	Transporter
B6254_2398	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
B6254_2400	ENOG4105CHR	reductase
B6254_2401	ENOG4105VUF	Transcriptional regulator
B6254_2403	ENOG4105CIG	ABC transporter
B6254_2407	ENOG4105CU6	carbamoyl-phosphate synthetase ammonia chain
B6254_2408	ENOG4105C1M	carbamoyl-phosphate synthetase glutamine chain
B6254_2409	ENOG4105DBV	ornithine carbamoyltransferase
B6254_2410	ENOG4105C8Y	Acetylornithine aminotransferase
B6254_2412	ENOG4105C5V	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity)
B6254_2413	ENOG4105C0N	N-acetylglutamate semialdehyde dehydrogenase
B6254_2414	ENOG4105CH7	arginosuccinase
B6254_2415	ENOG4105CDH	Citrulline--aspartate ligase
B6254_2416	ENOG4105DIH	basic membrane
B6254_2417	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
B6254_2418	ENOG4108HCJ	Hydrolase
B6254_2419	ENOG4107VQW	regulatoR
B6254_2427	ENOG4105CS2	ec 3.2.1.21
B6254_2428	ENOG4105C2X	Arabinose 5-phosphate isomerase
B6254_2436	ENOG4105KIS	phospholipid-binding protein
B6254_2442	ENOG4105CP7	Triose-phosphate isomerase
B6254_2444	ENOG4105C7N	Xanthine uracil vitamin C permease
B6254_2445	ENOG4105KAF	membrAne
B6254_2449	ENOG4108UMW	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
B6254_2451	ENOG4105DQF	Hydrolase
B6254_2452	ENOG4105EYF	MMPL domain protein
B6254_2453	ENOG4107RBB	ABC transporter, permease
B6254_2454	ENOG4105C19	ABC transporter
B6254_2459	ENOG4107QMW	pyridine nucleotide-disulfide oxidoreductase
B6254_2461	ENOG4107QN2	dihydrolipoyl dehydrogenase
B6254_2465	ENOG4105C85	amino acid
B6254_2466	ENOG4107ZYR	domain protein
B6254_2469	ENOG4105JKQ	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity)
B6254_2471	ENOG4105E0A	ABC, transporter
B6254_2472	ENOG4105C3F	Signal peptidase i
B6254_2473	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
B6254_2474	ENOG4105M7T	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)
B6254_2475	ENOG4105VG0	50S ribosomal protein l34
B6254_2512	ENOG4105K4U	addiction module toxin, RelE StbE family
B6254_2524	ENOG4105VBF	alkaline shock protein
B6254_2526	ENOG4107BMA	Transglycosylase associated protein
B6254_2534	ENOG4105VBF	alkaline shock protein
B6254_2536	ENOG4107BMA	Transglycosylase associated protein