locus-tag	class	description
B6254_0001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
B6254_0002	COG0592	DNA-directed DNA polymerase activity
B6254_0003	COG2501	S4 domain
B6254_0004	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
B6254_0005	COG0187	DNA topoisomerase II activity
B6254_0008	COG2153	protein acetylation
B6254_0009	COG1368	sulfuric ester hydrolase activity
B6254_0013	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
B6254_0025	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B6254_0025	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B6254_0027	COG0084	hydrolase, TatD family'
B6254_0028	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
B6254_0029	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
B6254_0030	COG1253	flavin adenine dinucleotide binding
B6254_0031	COG1253	flavin adenine dinucleotide binding
B6254_0032	COG4466	Protein conserved in bacteria
B6254_0033	COG2131	deaminase
B6254_0034	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
B6254_0035	COG1316	TRANSCRIPTIONal
B6254_0036	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B6254_0036	COG1263	PTS System
B6254_0037	COG2723	6-phospho-beta-galactosidase activity
B6254_0039	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
B6254_0042	COG0737	Belongs to the 5'-nucleotidase family
B6254_0043	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
B6254_0044	COG1983	PspC domain protein
B6254_0045	COG1695	Transcriptional regulator
B6254_0048	COG1968	undecaprenyl-diphosphatase activity
B6254_0049	COG2818	Glycosylase
B6254_0054	COG3507	Belongs to the glycosyl hydrolase 43 family
B6254_0055	COG2211	Major facilitator Superfamily
B6254_0057	COG2115	Belongs to the xylose isomerase family
B6254_0059	COG0667	Aldo Keto reductase
B6254_0063	COG0477	Major facilitator Superfamily
B6254_0064	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
B6254_0067	COG1309	transcriptional regulator
B6254_0068	COG1511	domain protein
B6254_0068	COG1511	domain protein
B6254_0070	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
B6254_0071	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
B6254_0073	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
B6254_0074	COG0297	glycogen (starch) synthase activity
B6254_0075	COG0058	SHG alpha-glucan phosphorylase activity
B6254_0077	COG0193	aminoacyl-tRNA hydrolase activity
B6254_0078	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
B6254_0079	COG2244	polysaccharide biosynthetic process
B6254_0080	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
B6254_0085	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
B6254_0086	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
B6254_0099	COG2261	transglycosylase associated protein
B6254_0100	COG0656	L-ascorbic acid biosynthetic process
B6254_0102	COG1737	Transcriptional regulator
B6254_0103	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
B6254_0111	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
B6254_0114	COG1216	Glycosyl transferase, family 2
B6254_0116	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
B6254_0117	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
B6254_0118	COG1447	Phosphotransferase system cellobiose-specific component IIA
B6254_0119	COG2723	6-phospho-beta-galactosidase activity
B6254_0120	COG2723	6-phospho-beta-galactosidase activity
B6254_0121	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
B6254_0123	COG0436	Aminotransferase
B6254_0124	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
B6254_0127	COG2211	Major facilitator Superfamily
B6254_0127	COG2190	(PTS) system
B6254_0128	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
B6254_0129	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
B6254_0130	COG0444	Belongs to the ABC transporter superfamily
B6254_0131	COG4608	Belongs to the ABC transporter superfamily
B6254_0132	COG0601	transmembrane transport
B6254_0133	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B6254_0134	COG0747	negative chemotaxis
B6254_0135	COG1132	(ABC) transporter
B6254_0136	COG1132	(ABC) transporter
B6254_0139	COG1956	GAF domain-containing protein
B6254_0142	COG2233	PERMEase
B6254_0143	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
B6254_0144	COG4989	oxidoreductase activity
B6254_0145	COG1620	l-lactate permease
B6254_0147	COG1028	Short-chain dehydrogenase reductase Sdr
B6254_0148	COG2084	Dehydrogenase
B6254_0153	COG0438	transferase activity, transferring glycosyl groups
B6254_0175	COG3842	ATPase activity
B6254_0176	COG1175	transmembrane transport
B6254_0177	COG0395	ABC-type sugar transport system, permease component
B6254_0180	COG0542	response to heat
B6254_0181	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B6254_0182	COG2040	homocysteine
B6254_0183	COG0833	amino acid
B6254_0184	COG0308	aminopeptidase N
B6254_0188	COG2207	Transcriptional regulator
B6254_0191	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
B6254_0192	COG0745	RESPONSE REGULATOR receiver
B6254_0193	COG2205	protein histidine kinase activity
B6254_0195	COG1316	TRANSCRIPTIONal
B6254_0197	COG0024	Methionine aminopeptidase
B6254_0199	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
B6254_0204	COG2723	6-phospho-beta-galactosidase activity
B6254_0209	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
B6254_0211	COG0671	phosphoesterase, PA-phosphatase related
B6254_0212	COG0495	leucyl-tRNA aminoacylation
B6254_0213	COG0438	transferase activity, transferring glycosyl groups
B6254_0215	COG2244	polysaccharide biosynthetic process
B6254_0219	COG0626	cystathionine gamma-synthase activity
B6254_0220	COG1902	pentaerythritol trinitrate reductase activity
B6254_0222	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
B6254_0223	COG0531	amino acid
B6254_0224	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B6254_0227	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
B6254_0228	COG1074	ATP-dependent DNA helicase activity
B6254_0229	COG1064	alcohol dehydrogenase
B6254_0230	COG2814	Major facilitator Superfamily
B6254_0233	COG1051	belongs to the nudix hydrolase family
B6254_0234	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
B6254_0236	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
B6254_0239	COG0360	Binds together with S18 to 16S ribosomal RNA
B6254_0240	COG0629	single-stranded DNA binding
B6254_0241	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
B6254_0247	COG0745	RESPONSE REGULATOR receiver
B6254_0251	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
B6254_0252	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B6254_0254	COG1078	dGTPase activity
B6254_0255	COG0561	phosphatase activity
B6254_0256	COG3343	RNA polymerase activity
B6254_0261	COG0504	CTP synthase activity
B6254_0262	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
B6254_0265	COG2337	Toxic component of a toxin-antitoxin (TA) module
B6254_0269	COG1696	Membrane protein involved in D-alanine export
B6254_0271	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
B6254_0275	COG3973	AAA domain
B6254_0278	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
B6254_0279	COG2211	Major facilitator Superfamily
B6254_0285	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
B6254_0285	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
B6254_0286	COG1268	BioY protein
B6254_0287	COG0194	GDP metabolic process
B6254_0290	COG1126	abc transporter atp-binding protein
B6254_0291	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B6254_0292	COG0765	amino acid transport
B6254_0293	COG0765	amino acid transport
B6254_0294	COG4166	transmembrane transport
B6254_0296	COG0601	transmembrane transport
B6254_0297	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B6254_0298	COG0444	Belongs to the ABC transporter superfamily
B6254_0299	COG4608	Belongs to the ABC transporter superfamily
B6254_0301	COG0359	binds to the 23S rRNA
B6254_0302	COG0305	Participates in initiation and elongation during chromosome replication
B6254_0303	COG2814	Major facilitator Superfamily
B6254_0305	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B6254_0311	COG2832	Protein of unknown function (DUF454)
B6254_0312	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
B6254_0314	COG1744	ABC transporter substrate-binding protein PnrA-like
B6254_0317	COG0492	ferredoxin-NADP+ reductase activity
B6254_0320	COG0588	phosphoglycerate mutase activity
B6254_0321	COG0386	Belongs to the glutathione peroxidase family
B6254_0323	COG0393	Putative heavy-metal-binding
B6254_0325	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
B6254_0326	COG0628	permease
B6254_0327	COG0640	Transcriptional regulator
B6254_0329	COG0446	pyridine nucleotide-disulphide oxidoreductase
B6254_0334	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
B6254_0335	COG1077	Cell shape determining protein MreB Mrl
B6254_0337	COG0772	Belongs to the SEDS family
B6254_0338	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
B6254_0344	COG0561	phosphatase activity
B6254_0345	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
B6254_0345	COG2169	Transcriptional regulator
B6254_0346	COG0561	phosphatase activity
B6254_0348	COG0577	efflux transmembrane transporter activity
B6254_0348	COG1136	(ABC) transporter
B6254_0353	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
B6254_0354	COG2814	Major facilitator Superfamily
B6254_0356	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
B6254_0357	COG0352	thiamine-phosphate diphosphorylase activity
B6254_0359	COG2252	PERMEase
B6254_0361	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
B6254_0372	COG4166	transmembrane transport
B6254_0373	COG1228	amidohydrolase
B6254_0377	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
B6254_0378	COG0656	L-ascorbic acid biosynthetic process
B6254_0379	COG1307	EDD domain protein, DegV family
B6254_0382	COG1435	thymidine kinase activity
B6254_0384	COG2076	Multidrug Resistance protein
B6254_0385	COG2076	Multidrug Resistance protein
B6254_0386	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
B6254_0386	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
B6254_0387	COG0307	riboflavin synthase, alpha
B6254_0388	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
B6254_0388	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
B6254_0389	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
B6254_0391	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
B6254_0392	COG0517	IMP dehydrogenase activity
B6254_0392	COG1125	glycine betaine transport
B6254_0393	COG1174	glycine betaine transport
B6254_0395	COG1979	alcohol dehydrogenase
B6254_0396	COG1811	Na channel or pump
B6254_0401	COG2246	polysaccharide biosynthetic process
B6254_0402	COG0561	phosphatase activity
B6254_0403	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
B6254_0404	COG4589	Belongs to the CDS family
B6254_0405	COG0750	zinc metalloprotease
B6254_0406	COG0442	prolyl-tRNA aminoacylation
B6254_0407	COG2176	DNA-directed DNA polymerase activity
B6254_0423	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
B6254_0425	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
B6254_0426	COG1040	competence protein
B6254_0427	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
B6254_0430	COG2183	response to ionizing radiation
B6254_0434	COG1940	carbohydrate kinase activity
B6254_0435	COG2723	6-phospho-beta-galactosidase activity
B6254_0436	COG3711	transcriptional antiterminator
B6254_0440	COG1309	transcriptional regulator
B6254_0444	COG2217	Heavy metal translocating P-type atpase
B6254_0445	COG2814	Major facilitator Superfamily
B6254_0452	COG2217	Heavy metal translocating P-type atpase
B6254_0454	COG2235	arginine
B6254_0455	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
B6254_0460	COG3759	membrane
B6254_0461	COG1136	(ABC) transporter
B6254_0462	COG0577	efflux transmembrane transporter activity
B6254_0471	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
B6254_0474	COG0246	Mannitol dehydrogenase
B6254_0475	COG1312	Catalyzes the dehydration of D-mannonate
B6254_0476	COG1904	glucuronate isomerase
B6254_0477	COG0800	Aldolase
B6254_0478	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B6254_0481	COG1464	Belongs to the NlpA lipoprotein family
B6254_0482	COG1506	peptidase
B6254_0482	COG0823	Involved in the tonB-independent uptake of proteins
B6254_0482	COG4946	Tricorn protease homolog
B6254_0484	COG0561	phosphatase activity
B6254_0489	COG0302	gtp cyclohydrolase
B6254_0489	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
B6254_0490	COG0302	gtp cyclohydrolase
B6254_0491	COG0285	dihydrofolate synthase activity
B6254_0493	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B6254_0496	COG0318	PFAM AMP-dependent synthetase and ligase
B6254_0498	COG2223	nitrite transmembrane transporter activity
B6254_0506	COG1609	Transcriptional regulator
B6254_0509	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B6254_0513	COG1609	Transcriptional regulator
B6254_0514	COG1869	D-ribose catabolic process
B6254_0515	COG0738	Major facilitator superfamily
B6254_0540	COG4166	transmembrane transport
B6254_0541	COG1228	amidohydrolase
B6254_0545	COG0516	GMP reductase activity
B6254_0551	COG0765	amino acid transport
B6254_0552	COG1126	abc transporter atp-binding protein
B6254_0554	COG0668	transmembrane transport
B6254_0558	COG0741	lytic transglycosylase activity
B6254_0559	COG0673	inositol 2-dehydrogenase activity
B6254_0560	COG0402	S-adenosylhomocysteine deaminase activity
B6254_0561	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
B6254_0562	COG0745	RESPONSE REGULATOR receiver
B6254_0563	COG3850	Histidine kinase
B6254_0563	COG5002	protein histidine kinase activity
B6254_0564	COG4975	Glucose uptake
B6254_0566	COG2017	converts alpha-aldose to the beta-anomer
B6254_0568	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
B6254_0569	COG1302	Protein conserved in bacteria
B6254_0572	COG0291	Belongs to the bacterial ribosomal protein bL35 family
B6254_0573	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
B6254_0576	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
B6254_0577	COG0626	cystathionine gamma-synthase activity
B6254_0578	COG0460	homoserine dehydrogenase
B6254_0580	COG0601	transmembrane transport
B6254_0581	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B6254_0582	COG0444	Belongs to the ABC transporter superfamily
B6254_0583	COG4608	Belongs to the ABC transporter superfamily
B6254_0584	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
B6254_0585	COG0049	tRNA binding
B6254_0586	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
B6254_0588	COG3842	ATPase activity
B6254_0589	COG1176	ABC-type spermidine putrescine transport system, permease component I
B6254_0590	COG1177	transmembrane transport
B6254_0592	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
B6254_0594	COG0589	response to stress
B6254_0596	COG1950	PFAM Membrane protein of
B6254_0597	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
B6254_0598	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
B6254_0603	COG0492	ferredoxin-NADP+ reductase activity
B6254_0604	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B6254_0606	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
B6254_0607	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
B6254_0608	COG0149	triose-phosphate isomerase activity
B6254_0612	COG0154	amidase activity
B6254_0615	COG0557	exoribonuclease II activity
B6254_0618	COG2814	Major facilitator Superfamily
B6254_0620	COG0765	amino acid transport
B6254_0621	COG1126	abc transporter atp-binding protein
B6254_0622	COG2076	Multidrug Resistance protein
B6254_0623	COG2076	Multidrug Resistance protein
B6254_0625	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
B6254_0626	COG0280	phosphate acetyltransferase
B6254_0627	COG0802	atpase or kinase
B6254_0630	COG0812	UDP-N-acetylmuramate dehydrogenase activity
B6254_0633	COG4856	YbbR-like protein
B6254_0634	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B6254_0638	COG0540	Belongs to the ATCase OTCase family
B6254_0639	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
B6254_0640	COG0505	Belongs to the CarA family
B6254_0641	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
B6254_0642	COG0167	dihydroorotate dehydrogenase activity
B6254_0643	COG0284	orotidine-5'-phosphate decarboxylase activity
B6254_0644	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
B6254_0645	COG0438	transferase activity, transferring glycosyl groups
B6254_0646	COG0438	transferase activity, transferring glycosyl groups
B6254_0649	COG1368	sulfuric ester hydrolase activity
B6254_0661	COG1397	ADP-ribosylglycohydrolase
B6254_0664	COG3715	PTS system
B6254_0665	COG3716	PTS system mannose fructose sorbose family IID component
B6254_0667	COG0588	phosphoglycerate mutase activity
B6254_0677	COG0126	phosphoglycerate kinase activity
B6254_0678	COG0583	DNA-binding transcription factor activity
B6254_0680	COG0105	UTP biosynthetic process
B6254_0681	COG1012	belongs to the aldehyde dehydrogenase family
B6254_0681	COG1454	alcohol dehydrogenase
B6254_0683	COG0656	L-ascorbic acid biosynthetic process
B6254_0687	COG4974	Belongs to the 'phage' integrase family
B6254_0754	COG1113	amino acid transport
B6254_0755	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
B6254_0757	COG0328	RNA-DNA hybrid ribonuclease activity
B6254_0759	COG0564	pseudouridine synthase activity
B6254_0761	COG0505	Belongs to the CarA family
B6254_0763	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
B6254_0764	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
B6254_0766	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
B6254_0767	COG1846	Transcriptional regulator
B6254_0768	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B6254_0769	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B6254_0770	COG2070	2-Nitropropane dioxygenase
B6254_0771	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
B6254_0772	COG1028	Short-chain dehydrogenase reductase Sdr
B6254_0773	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
B6254_0776	COG0439	Biotin carboxylase
B6254_0777	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
B6254_0779	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
B6254_0782	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B6254_0783	COG4115	mRNA cleavage
B6254_0785	COG1704	LemA family
B6254_0786	COG0501	Belongs to the peptidase M48B family
B6254_0788	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
B6254_0789	COG0673	inositol 2-dehydrogenase activity
B6254_0790	COG0513	Belongs to the DEAD box helicase family
B6254_0794	COG3764	Sortase (surface protein transpeptidase)
B6254_0795	COG1321	iron dependent repressor
B6254_0798	COG0083	homoserine kinase activity
B6254_0799	COG1609	Transcriptional regulator
B6254_0801	COG0527	aspartate kinase activity
B6254_0802	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
B6254_0804	COG2171	N-acyltransferase activity
B6254_0806	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B6254_0807	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
B6254_0808	COG0436	Aminotransferase
B6254_0809	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
B6254_0810	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
B6254_0813	COG0436	Aminotransferase
B6254_0814	COG4684	Psort location CytoplasmicMembrane, score
B6254_0817	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
B6254_0818	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
B6254_0819	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
B6254_0820	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
B6254_0821	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
B6254_0822	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
B6254_0823	COG0710	3-dehydroquinate dehydratase activity
B6254_0826	COG1122	ATPase activity
B6254_0827	COG4721	ABC-type cobalt transport system, permease component
B6254_0828	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
B6254_0829	COG0667	Aldo Keto reductase
B6254_0833	COG1914	H( )-stimulated, divalent metal cation uptake system
B6254_0835	COG1695	Transcriptional regulator
B6254_0840	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
B6254_0840	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
B6254_0841	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
B6254_0842	COG0154	amidase activity
B6254_0843	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
B6254_0844	COG1597	lipid kinase activity
B6254_0848	COG1121	(ABC) transporter
B6254_0853	COG0018	arginyl-trna synthetase
B6254_0857	COG1438	arginine binding
B6254_0858	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
B6254_0859	COG3679	Belongs to the UPF0342 family
B6254_0861	COG4717	serine-type aminopeptidase activity
B6254_0865	COG0028	Belongs to the TPP enzyme family
B6254_0868	COG0612	Peptidase, M16
B6254_0869	COG0612	Peptidase, M16
B6254_0870	COG1426	Protein conserved in bacteria
B6254_0871	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
B6254_0873	COG1058	Belongs to the CinA family
B6254_0873	COG1546	Belongs to the CinA family
B6254_0874	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
B6254_0876	COG3973	AAA domain
B6254_0877	COG1072	(Pantothenic acid kinase))
B6254_0878	COG0741	lytic transglycosylase activity
B6254_0879	COG2814	Major facilitator Superfamily
B6254_0881	COG1278	Cold shock
B6254_0882	COG0564	pseudouridine synthase activity
B6254_0885	COG2309	aminopeptidase activity
B6254_0910	COG3883	PFAM NLP P60 protein
B6254_0910	COG0791	NLP P60 protein
B6254_0914	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B6254_0918	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
B6254_0920	COG3475	LICD family
B6254_0921	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
B6254_0922	COG1063	alcohol dehydrogenase
B6254_0923	COG1134	teichoic acid transport
B6254_0923	COG1388	LysM domain
B6254_0924	COG1682	transport, permease protein
B6254_0928	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
B6254_0935	COG4974	Belongs to the 'phage' integrase family
B6254_0938	COG1396	sequence-specific DNA binding
B6254_0948	COG0629	single-stranded DNA binding
B6254_0987	COG0024	Methionine aminopeptidase
B6254_0993	COG0562	UDP-galactopyranose mutase
B6254_0996	COG1705	Flagellar rod assembly protein muramidase FlgJ
B6254_0998	COG0463	Glycosyl transferase, family 2
B6254_1000	COG1216	Glycosyl transferase, family 2
B6254_1006	COG1420	regulation of RNA biosynthetic process
B6254_1008	COG0443	Heat shock 70 kDa protein
B6254_1009	COG0484	heat shock protein binding
B6254_1012	COG1234	tRNA 3'-trailer cleavage
B6254_1013	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
B6254_1013	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
B6254_1017	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
B6254_1018	COG4224	UPF0291 protein
B6254_1019	COG3763	UPF0154 protein
B6254_1022	COG3883	PFAM NLP P60 protein
B6254_1022	COG0791	NLP P60 protein
B6254_1023	COG0204	Acyl-transferase
B6254_1024	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
B6254_1025	COG2827	Endonuclease containing a URI domain
B6254_1026	COG0052	Belongs to the universal ribosomal protein uS2 family
B6254_1027	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
B6254_1029	COG0233	cytoplasmic translational termination
B6254_1030	COG4464	protein tyrosine phosphatase activity
B6254_1032	COG0489	protein tyrosine kinase activity
B6254_1033	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
B6254_1034	COG0438	transferase activity, transferring glycosyl groups
B6254_1036	COG1216	Glycosyl transferase, family 2
B6254_1039	COG1216	Glycosyl transferase, family 2
B6254_1040	COG1316	TRANSCRIPTIONal
B6254_1041	COG5263	repeat protein
B6254_1041	COG0366	Alpha amylase catalytic
B6254_1043	COG0004	ammonium transporteR
B6254_1044	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
B6254_1048	COG0617	tRNA 3'-terminal CCA addition
B6254_1049	COG0488	(ABC) transporter
B6254_1050	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
B6254_1052	COG0587	DNA-directed DNA polymerase activity
B6254_1053	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
B6254_1054	COG1490	D-aminoacyl-tRNA deacylase activity
B6254_1056	COG0475	glutathione-regulated potassium exporter activity
B6254_1058	COG2996	Protein conserved in bacteria
B6254_1061	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
B6254_1062	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
B6254_1063	COG1187	pseudouridine synthase activity
B6254_1066	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
B6254_1068	COG0514	ATP-dependent DNA helicase (RecQ)
B6254_1070	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
B6254_1071	COG0539	negative regulation of cytoplasmic translation
B6254_1072	COG1160	GTP binding
B6254_1074	COG0351	phosphomethylpyrimidine kinase
B6254_1075	COG4720	Psort location CytoplasmicMembrane, score
B6254_1076	COG2807	transmembrane transport
B6254_1079	COG0419	ATPase involved in DNA repair
B6254_1088	COG0457	Tetratricopeptide repeat
B6254_1089	COG0071	Belongs to the small heat shock protein (HSP20) family
B6254_1090	COG2384	SAM-dependent methyltransferase
B6254_1091	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
B6254_1093	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
B6254_1097	COG0267	Belongs to the bacterial ribosomal protein bL33 family
B6254_1098	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
B6254_1102	COG0577	efflux transmembrane transporter activity
B6254_1103	COG1136	(ABC) transporter
B6254_1106	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B6254_1108	COG0281	malic enzyme
B6254_1109	COG0583	DNA-binding transcription factor activity
B6254_1110	COG4221	oxidoreductase activity
B6254_1111	COG0531	amino acid
B6254_1113	COG4708	membrane
B6254_1114	COG1028	Short-chain dehydrogenase reductase Sdr
B6254_1121	COG0481	GTPase activity
B6254_1123	COG0531	amino acid
B6254_1127	COG2723	6-phospho-beta-galactosidase activity
B6254_1129	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
B6254_1131	COG0306	phosphate transporter
B6254_1133	COG1609	Transcriptional regulator
B6254_1135	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B6254_1135	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B6254_1135	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
B6254_1136	COG1105	Belongs to the carbohydrate kinase PfkB family
B6254_1137	COG1349	DNA-binding transcription factor activity
B6254_1138	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
B6254_1139	COG0446	pyridine nucleotide-disulphide oxidoreductase
B6254_1144	COG1397	ADP-ribosylglycohydrolase
B6254_1145	COG1719	4-vinyl reductase, 4VR
B6254_1146	COG0220	tRNA (guanine-N7-)-methyltransferase activity
B6254_1148	COG1131	(ABC) transporter
B6254_1149	COG0537	adenosine 5'-monophosphoramidase activity
B6254_1151	COG0363	glucosamine-6-phosphate deaminase activity
B6254_1152	COG3104	oligopeptide transport
B6254_1153	COG0825	malonyl-CoA metabolic process
B6254_1154	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
B6254_1155	COG0439	Biotin carboxylase
B6254_1157	COG0556	nucleotide-excision repair
B6254_1161	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
B6254_1163	COG0116	Belongs to the methyltransferase superfamily
B6254_1164	COG3599	regulation of cell shape
B6254_1165	COG4474	Belongs to the UPF0398 family
B6254_1166	COG3331	DNA recombination
B6254_1168	COG3935	DnaD domain protein
B6254_1189	COG0228	four-way junction DNA binding
B6254_1217	COG3723	Recombinational DNA repair protein, rece pathway
B6254_1231	COG0582	viral genome integration into host DNA
B6254_1232	COG0017	Asparaginyl-tRNA synthetase
B6254_1234	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
B6254_1234	COG1199	ATP-dependent helicase activity
B6254_1238	COG1304	FMN binding
B6254_1240	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
B6254_1241	COG1028	Short-chain dehydrogenase reductase Sdr
B6254_1242	COG0706	membrane insertase activity
B6254_1245	COG0531	amino acid
B6254_1247	COG1388	LysM domain
B6254_1247	COG1705	Flagellar rod assembly protein muramidase FlgJ
B6254_1249	COG5002	protein histidine kinase activity
B6254_1250	COG0745	RESPONSE REGULATOR receiver
B6254_1253	COG1484	DNA-dependent DNA replication
B6254_1255	COG0237	dephospho-CoA kinase activity
B6254_1256	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
B6254_1257	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B6254_1257	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B6254_1258	COG0670	Belongs to the BI1 family
B6254_1259	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
B6254_1261	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B6254_1262	COG1363	Peptidase, m42
B6254_1263	COG0572	uridine kinase
B6254_1264	COG5002	protein histidine kinase activity
B6254_1265	COG0745	RESPONSE REGULATOR receiver
B6254_1271	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
B6254_1272	COG0358	DNA primase activity
B6254_1278	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
B6254_1283	COG0741	lytic transglycosylase activity
B6254_1283	COG0739	heme binding
B6254_1283	COG1196	nuclear chromosome segregation
B6254_1289	COG1192	Involved in chromosome partitioning
B6254_1294	COG0542	response to heat
B6254_1314	COG0673	inositol 2-dehydrogenase activity
B6254_1316	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B6254_1320	COG0406	alpha-ribazole phosphatase activity
B6254_1321	COG0583	DNA-binding transcription factor activity
B6254_1327	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
B6254_1328	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
B6254_1340	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
B6254_1341	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
B6254_1343	COG0477	Major facilitator Superfamily
B6254_1344	COG3480	Lon protease (S16) C-terminal proteolytic domain
B6254_1345	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
B6254_1346	COG0742	ribosomal rna small subunit methyltransferase
B6254_1347	COG4471	UPF0298 protein
B6254_1348	COG0772	Belongs to the SEDS family
B6254_1350	COG0483	inositol monophosphate 1-phosphatase activity
B6254_1351	COG4476	Belongs to the UPF0223 family
B6254_1352	COG0242	peptide deformylase activity
B6254_1359	COG1011	Hydrolase
B6254_1360	COG1597	lipid kinase activity
B6254_1361	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
B6254_1362	COG1464	Belongs to the NlpA lipoprotein family
B6254_1363	COG0446	pyridine nucleotide-disulphide oxidoreductase
B6254_1366	COG3448	diguanylate cyclase activity
B6254_1366	COG4175	Glycine betaine
B6254_1369	COG1227	inorganic diphosphatase activity
B6254_1370	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
B6254_1372	COG4974	Belongs to the 'phage' integrase family
B6254_1373	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
B6254_1374	COG0758	DNA mediated transformation
B6254_1375	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
B6254_1377	COG4479	Belongs to the UPF0346 family
B6254_1379	COG2755	lipolytic protein G-D-S-L family
B6254_1380	COG1307	EDD domain protein, DegV family
B6254_1381	COG1307	EDD domain protein, DegV family
B6254_1382	COG2270	Major facilitator Superfamily
B6254_1385	COG3142	Participates in the control of copper homeostasis
B6254_1387	COG0196	riboflavin kinase activity
B6254_1389	COG1252	NADH dehydrogenase
B6254_1390	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
B6254_1391	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
B6254_1392	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
B6254_1394	COG2740	Nucleic-acid-binding protein implicated in transcription termination
B6254_1395	COG0195	Participates in both transcription termination and antitermination
B6254_1396	COG0779	Required for maturation of 30S ribosomal subunits
B6254_1399	COG1304	FMN binding
B6254_1405	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
B6254_1406	COG0738	Major facilitator superfamily
B6254_1407	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
B6254_1409	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
B6254_1410	COG4684	Psort location CytoplasmicMembrane, score
B6254_1411	COG1621	beta-fructofuranosidase activity
B6254_1414	COG0384	phenazine biosynthesis protein PhzF
B6254_1419	COG1942	4-Oxalocrotonate Tautomerase
B6254_1422	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
B6254_1438	COG0456	acetyltransferase
B6254_1439	COG1846	Transcriptional regulator
B6254_1441	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
B6254_1442	COG0656	L-ascorbic acid biosynthetic process
B6254_1444	COG0583	DNA-binding transcription factor activity
B6254_1445	COG4166	transmembrane transport
B6254_1455	COG2814	Major facilitator Superfamily
B6254_1456	COG2239	Acts as a magnesium transporter
B6254_1457	COG0564	pseudouridine synthase activity
B6254_1458	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
B6254_1459	COG2357	RelA SpoT domain protein
B6254_1463	COG1518	maintenance of DNA repeat elements
B6254_1466	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
B6254_1467	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
B6254_1484	COG1940	carbohydrate kinase activity
B6254_1486	COG1028	Short-chain dehydrogenase reductase Sdr
B6254_1491	COG0352	thiamine-phosphate diphosphorylase activity
B6254_1492	COG0351	phosphomethylpyrimidine kinase
B6254_1493	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
B6254_1496	COG1464	Belongs to the NlpA lipoprotein family
B6254_1499	COG0436	Aminotransferase
B6254_1500	COG0277	FAD linked oxidase domain protein
B6254_1517	COG1122	ATPase activity
B6254_1518	COG4720	Psort location CytoplasmicMembrane, score
B6254_1520	COG3321	synthase
B6254_1520	COG0604	alcohol dehydrogenase
B6254_1522	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
B6254_1523	COG0277	FAD linked oxidase domain protein
B6254_1525	COG0028	Belongs to the TPP enzyme family
B6254_1532	COG3201	nicotinamide mononucleotide transporter
B6254_1533	COG1434	Gram-negative-bacterium-type cell wall biogenesis
B6254_1538	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
B6254_1541	COG1473	amidohydrolase
B6254_1542	COG3527	Alpha-acetolactate decarboxylase
B6254_1543	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
B6254_1544	COG0187	DNA topoisomerase II activity
B6254_1545	COG3118	belongs to the thioredoxin family
B6254_1549	COG1193	negative regulation of DNA recombination
B6254_1553	COG0218	Necessary for normal cell division and for the maintenance of normal septation
B6254_1555	COG0544	peptidyl-prolyl cis-trans isomerase activity
B6254_1560	COG0268	Binds directly to 16S ribosomal RNA
B6254_1561	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
B6254_1562	COG1466	dna polymerase III delta subunit
B6254_1563	COG0658	competence protein
B6254_1563	COG2333	competence protein COMEC
B6254_1565	COG3906	Belongs to the UPF0473 family
B6254_1569	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
B6254_1570	COG1929	Belongs to the glycerate kinase type-1 family
B6254_1571	COG0513	Belongs to the DEAD box helicase family
B6254_1572	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
B6254_1573	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
B6254_1574	COG1862	Preprotein translocase
B6254_1575	COG0343	queuine tRNA-ribosyltransferase activity
B6254_1582	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
B6254_1583	COG2255	four-way junction helicase activity
B6254_1584	COG0632	four-way junction helicase activity
B6254_1585	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
B6254_1586	COG0516	GMP reductase activity
B6254_1586	COG0517	IMP dehydrogenase activity
B6254_1590	COG1739	Uncharacterized protein family UPF0029
B6254_1591	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
B6254_1592	COG0322	excinuclease ABC activity
B6254_1595	COG1668	transmembrane transport
B6254_1596	COG4152	abc transporter atp-binding protein
B6254_1598	COG1674	ftsk spoiiie
B6254_1600	COG0628	permease
B6254_1601	COG2706	6-phosphogluconolactonase activity
B6254_1605	COG0751	glycine-tRNA ligase activity
B6254_1606	COG0752	glycyl-tRNA synthetase alpha subunit
B6254_1609	COG1381	Involved in DNA repair and RecF pathway recombination
B6254_1610	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
B6254_1611	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
B6254_1612	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
B6254_1613	COG1702	phosphate starvation-inducible protein PhoH
B6254_1614	COG1610	YqeY-like protein
B6254_1615	COG0828	Belongs to the bacterial ribosomal protein bS21 family
B6254_1616	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
B6254_1618	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
B6254_1619	COG0124	histidyl-tRNA synthetase
B6254_1620	COG0860	N-Acetylmuramoyl-L-alanine amidase
B6254_1623	COG3425	synthase
B6254_1624	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
B6254_1638	COG0006	proline dipeptidase activity
B6254_1639	COG1609	Transcriptional regulator
B6254_1642	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
B6254_1643	COG1164	Oligoendopeptidase f
B6254_1645	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
B6254_1646	COG2723	6-phospho-beta-galactosidase activity
B6254_1647	COG1447	Phosphotransferase system cellobiose-specific component IIA
B6254_1648	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
B6254_1649	COG2723	6-phospho-beta-galactosidase activity
B6254_1650	COG4862	establishment of competence for transformation
B6254_1651	COG1393	Belongs to the ArsC family
B6254_1652	COG3853	Toxic anion resistance protein (TelA)
B6254_1666	COG0561	phosphatase activity
B6254_1667	COG1970	mechanosensitive ion channel activity
B6254_1668	COG1428	Deoxynucleoside kinase
B6254_1670	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
B6254_1671	COG1942	4-Oxalocrotonate Tautomerase
B6254_1672	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
B6254_1674	COG0335	large ribosomal subunit rRNA binding
B6254_1675	COG0336	Belongs to the RNA methyltransferase TrmD family
B6254_1676	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
B6254_1677	COG0588	phosphoglycerate mutase activity
B6254_1681	COG0228	four-way junction DNA binding
B6254_1685	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
B6254_1687	COG0552	protein localization to endoplasmic reticulum
B6254_1688	COG1196	nuclear chromosome segregation
B6254_1689	COG0571	ribonuclease III activity
B6254_1690	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B6254_1691	COG0416	fatty acid biosynthetic process
B6254_1692	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
B6254_1694	COG0438	transferase activity, transferring glycosyl groups
B6254_1697	COG1461	Dihydroxyacetone kinase
B6254_1699	COG0227	Belongs to the bacterial ribosomal protein bL28 family
B6254_1701	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
B6254_1702	COG1162	GTPase activity
B6254_1703	COG2815	serine threonine protein kinase
B6254_1703	COG0515	serine threonine protein kinase
B6254_1704	COG0631	protein serine/threonine phosphatase activity
B6254_1705	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
B6254_1705	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
B6254_1706	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
B6254_1707	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
B6254_1708	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
B6254_1716	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
B6254_1717	COG2252	PERMEase
B6254_1718	COG0217	transcriptional regulatory protein
B6254_1719	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
B6254_1723	COG3599	regulation of cell shape
B6254_1726	COG1799	cell septum assembly
B6254_1728	COG0849	cell division
B6254_1729	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
B6254_1730	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
B6254_1731	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
B6254_1732	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
B6254_1735	COG0275	rRNA processing
B6254_1736	COG2001	Belongs to the MraZ family
B6254_1738	COG1385	rRNA (uridine-N3-)-methyltransferase activity
B6254_1739	COG2264	protein methyltransferase activity
B6254_1742	COG0833	amino acid
B6254_1746	COG0446	pyridine nucleotide-disulphide oxidoreductase
B6254_1749	COG2759	Belongs to the formate--tetrahydrofolate ligase family
B6254_1750	COG0151	Belongs to the GarS family
B6254_1751	COG0138	bifunctional purine biosynthesis protein purh
B6254_1752	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
B6254_1753	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
B6254_1755	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
B6254_1756	COG0047	phosphoribosylformylglycinamidine synthase activity
B6254_1757	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
B6254_1758	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
B6254_1759	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
B6254_1760	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
B6254_1763	COG1126	abc transporter atp-binding protein
B6254_1764	COG0765	amino acid transport
B6254_1766	COG3338	carbonate dehydratase activity
B6254_1767	COG1792	Involved in formation and maintenance of cell shape
B6254_1768	COG1077	Cell shape determining protein MreB Mrl
B6254_1769	COG2003	Belongs to the UPF0758 family
B6254_1772	COG1263	PTS System
B6254_1772	COG2190	(PTS) system
B6254_1772	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B6254_1773	COG1307	EDD domain protein, DegV family
B6254_1774	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
B6254_1775	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
B6254_1776	COG0038	chloride channel
B6254_1778	COG4120	Belongs to the binding-protein-dependent transport system permease family
B6254_1780	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B6254_1781	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B6254_1786	COG0741	lytic transglycosylase activity
B6254_1788	COG0400	carboxylic ester hydrolase activity
B6254_1789	COG0346	lactoylglutathione lyase activity
B6254_1790	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
B6254_1792	COG0494	nUDIX hydrolase
B6254_1796	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
B6254_1797	COG1388	LysM domain
B6254_1797	COG1705	Flagellar rod assembly protein muramidase FlgJ
B6254_1798	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
B6254_1799	COG4988	ABC transporter
B6254_1800	COG1294	oxidase, subunit
B6254_1801	COG1271	oxidase subunit
B6254_1802	COG4684	Psort location CytoplasmicMembrane, score
B6254_1825	COG1098	S1 RNA binding domain
B6254_1826	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
B6254_1827	COG0586	Pfam SNARE associated Golgi protein
B6254_1829	COG0194	GDP metabolic process
B6254_1831	COG0497	DNA recombination
B6254_1832	COG1438	arginine binding
B6254_1833	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
B6254_1834	COG0142	geranyltranstransferase activity
B6254_1836	COG1570	exodeoxyribonuclease VII activity
B6254_1837	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
B6254_1838	COG4720	Psort location CytoplasmicMembrane, score
B6254_1841	COG1136	(ABC) transporter
B6254_1842	COG0577	efflux transmembrane transporter activity
B6254_1844	COG0776	regulation of translation
B6254_1845	COG0363	glucosamine-6-phosphate deaminase activity
B6254_1846	COG3764	Sortase (surface protein transpeptidase)
B6254_1847	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
B6254_1867	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
B6254_1868	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
B6254_1870	COG1323	Belongs to the UPF0348 family
B6254_1871	COG2226	methyltransferase
B6254_1872	COG0799	negative regulation of ribosome biogenesis
B6254_1873	COG1713	HD superfamily hydrolase involved in NAD metabolism
B6254_1874	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
B6254_1876	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
B6254_1877	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
B6254_1878	COG1181	Belongs to the D-alanine--D-alanine ligase family
B6254_1880	COG0531	amino acid
B6254_1881	COG0459	protein refolding
B6254_1882	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
B6254_1883	COG0488	(ABC) transporter
B6254_1887	COG0285	dihydrofolate synthase activity
B6254_1889	COG0525	valine-tRNA ligase activity
B6254_1895	COG1272	protein, Hemolysin III
B6254_1919	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
B6254_1922	COG5506	Protein of unknown function (DUF1694)
B6254_1924	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
B6254_1929	COG2137	regulation of response to DNA damage stimulus
B6254_1930	COG0704	Plays a role in the regulation of phosphate uptake
B6254_1931	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
B6254_1932	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
B6254_1933	COG0581	inorganic phosphate transmembrane transporter activity
B6254_1934	COG0573	inorganic phosphate transmembrane transporter activity
B6254_1935	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
B6254_1940	COG0673	inositol 2-dehydrogenase activity
B6254_1941	COG4166	transmembrane transport
B6254_1942	COG0647	UMP catabolic process
B6254_1943	COG4470	Protein conserved in bacteria
B6254_1944	COG0737	Belongs to the 5'-nucleotidase family
B6254_1948	COG4948	Mandelate Racemase Muconate Lactonizing
B6254_1949	COG0596	Alpha beta hydrolase
B6254_1950	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
B6254_1951	COG1169	isochorismate synthase
B6254_1952	COG0778	Nitroreductase
B6254_1953	COG1132	(ABC) transporter
B6254_1961	COG1472	Belongs to the glycosyl hydrolase 3 family
B6254_1963	COG0211	Belongs to the bacterial ribosomal protein bL27 family
B6254_1964	COG0261	This protein binds to 23S rRNA in the presence of protein L20
B6254_1969	COG0174	glutamine synthetase
B6254_1970	COG0789	Transcriptional regulator
B6254_1971	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
B6254_1972	COG0584	glycerophosphoryl diester phosphodiesterase
B6254_1976	COG3942	CHAP domain
B6254_1978	COG1940	carbohydrate kinase activity
B6254_1981	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
B6254_1982	COG0768	penicillin binding
B6254_1984	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
B6254_1985	COG0514	ATP-dependent DNA helicase (RecQ)
B6254_1986	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
B6254_1987	COG0072	phenylalanine-tRNA ligase activity
B6254_1987	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B6254_1988	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
B6254_1990	COG1733	regulation of RNA biosynthetic process
B6254_1992	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
B6254_1996	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
B6254_1997	COG0653	protein targeting
B6254_1999	COG4956	integral membrane protein (PIN domain superfamily)
B6254_2001	COG0756	dUTP diphosphatase activity
B6254_2004	COG1388	LysM domain
B6254_2004	COG3942	CHAP domain
B6254_2006	COG3527	Alpha-acetolactate decarboxylase
B6254_2007	COG0028	Belongs to the TPP enzyme family
B6254_2008	COG0039	L-malate dehydrogenase activity
B6254_2009	COG2514	catechol 2,3-dioxygenase activity
B6254_2021	COG4974	Belongs to the 'phage' integrase family
B6254_2025	COG1914	H( )-stimulated, divalent metal cation uptake system
B6254_2027	COG1263	PTS System
B6254_2027	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B6254_2030	COG0740	serine-type endopeptidase activity
B6254_2031	COG1481	regulation of sporulation
B6254_2032	COG0391	Required for morphogenesis under gluconeogenic growth conditions
B6254_2033	COG1660	Displays ATPase and GTPase activities
B6254_2035	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
B6254_2036	COG2814	Major facilitator Superfamily
B6254_2038	COG0671	phosphoesterase, PA-phosphatase related
B6254_2043	COG1573	uracil-dna glycosylase
B6254_2046	COG0028	Belongs to the TPP enzyme family
B6254_2051	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
B6254_2052	COG0101	tRNA pseudouridine synthase activity
B6254_2054	COG1122	ATPase activity
B6254_2055	COG1122	ATPase activity
B6254_2057	COG1252	NADH dehydrogenase
B6254_2058	COG0803	Belongs to the bacterial solute-binding protein 9 family
B6254_2059	COG1108	ABC-type Mn2 Zn2 transport systems permease components
B6254_2060	COG1121	(ABC) transporter
B6254_2062	COG0222	ribosome binding
B6254_2063	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
B6254_2064	COG0081	regulation of translation
B6254_2065	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
B6254_2066	COG0250	Participates in transcription elongation, termination and antitermination
B6254_2067	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
B6254_2069	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
B6254_2070	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
B6254_2071	COG1854	S-ribosylhomocysteine lyase activity
B6254_2072	COG1464	Belongs to the NlpA lipoprotein family
B6254_2073	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
B6254_2074	COG0626	cystathionine gamma-synthase activity
B6254_2075	COG0215	cysteine-tRNA ligase activity
B6254_2076	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
B6254_2077	COG0039	L-malate dehydrogenase activity
B6254_2078	COG0471	metal ion transport
B6254_2079	COG1053	succinate dehydrogenase
B6254_2080	COG0114	fumarate hydratase activity
B6254_2081	COG0583	DNA-binding transcription factor activity
B6254_2086	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
B6254_2089	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
B6254_2094	COG0203	ribosomal protein L17
B6254_2095	COG0202	RNA polymerase activity
B6254_2096	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
B6254_2098	COG0257	Belongs to the bacterial ribosomal protein bL36 family
B6254_2099	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
B6254_2102	COG0200	Binds to the 23S rRNA
B6254_2103	COG1841	ribosomal large subunit assembly
B6254_2104	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
B6254_2105	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
B6254_2106	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
B6254_2107	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
B6254_2108	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
B6254_2109	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
B6254_2110	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
B6254_2112	COG0255	Belongs to the universal ribosomal protein uL29 family
B6254_2113	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
B6254_2114	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
B6254_2115	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
B6254_2116	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
B6254_2117	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
B6254_2118	COG0089	rRNA binding
B6254_2120	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
B6254_2121	COG0051	transcription antitermination factor activity, RNA binding
B6254_2122	COG0142	geranyltranstransferase activity
B6254_2123	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
B6254_2125	COG0456	acetyltransferase
B6254_2126	COG1214	PFAM Peptidase M22, glycoprotease
B6254_2127	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
B6254_2131	COG3870	Protein conserved in bacteria
B6254_2132	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
B6254_2137	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
B6254_2138	COG0590	tRNA wobble adenosine to inosine editing
B6254_2139	COG2813	Specifically methylates the guanine in position
B6254_2141	COG2807	transmembrane transport
B6254_2143	COG3620	sequence-specific DNA binding
B6254_2151	COG0500	methyltransferase
B6254_2152	COG1309	transcriptional regulator
B6254_2158	COG1979	alcohol dehydrogenase
B6254_2162	COG0085	RNA polymerase activity
B6254_2163	COG0542	response to heat
B6254_2164	COG4463	regulation of RNA biosynthetic process
B6254_2169	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
B6254_2170	COG1428	Deoxynucleoside kinase
B6254_2172	COG0355	proton-transporting ATP synthase activity, rotational mechanism
B6254_2173	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
B6254_2174	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
B6254_2175	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
B6254_2176	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
B6254_2177	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
B6254_2178	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
B6254_2179	COG0356	it plays a direct role in the translocation of protons across the membrane
B6254_2180	COG2233	PERMEase
B6254_2182	COG0702	epimerase
B6254_2183	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
B6254_2184	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
B6254_2185	COG0009	L-threonylcarbamoyladenylate synthase
B6254_2186	COG2890	protein-(glutamine-N5) methyltransferase activity
B6254_2187	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
B6254_2188	COG1435	thymidine kinase activity
B6254_2190	COG3442	glutamine amidotransferase
B6254_2191	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
B6254_2192	COG1482	cell wall glycoprotein biosynthetic process
B6254_2194	COG0110	maltose O-acetyltransferase activity
B6254_2199	COG1132	(ABC) transporter
B6254_2200	COG1132	(ABC) transporter
B6254_2204	COG0588	phosphoglycerate mutase activity
B6254_2208	COG0708	Exodeoxyribonuclease III
B6254_2209	COG1373	ATPase (AAA superfamily
B6254_2211	COG1454	alcohol dehydrogenase
B6254_2211	COG1012	belongs to the aldehyde dehydrogenase family
B6254_2213	COG3590	peptidase
B6254_2222	COG5039	Polysaccharide pyruvyl transferase
B6254_2224	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
B6254_2228	COG1442	glycosyl transferase family 8
B6254_2228	COG1216	Glycosyl transferase, family 2
B6254_2229	COG0438	transferase activity, transferring glycosyl groups
B6254_2236	COG1216	Glycosyl transferase, family 2
B6254_2237	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
B6254_2238	COG2188	Transcriptional regulator
B6254_2239	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
B6254_2240	COG2814	Major facilitator Superfamily
B6254_2241	COG1418	mRNA catabolic process
B6254_2244	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
B6254_2245	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
B6254_2246	COG1215	transferase activity, transferring glycosyl groups
B6254_2253	COG0765	amino acid transport
B6254_2258	COG0656	L-ascorbic acid biosynthetic process
B6254_2259	COG2160	L-arabinose isomerase activity
B6254_2263	COG3940	Belongs to the glycosyl hydrolase 43 family
B6254_2266	COG0534	Mate efflux family protein
B6254_2267	COG0488	(ABC) transporter
B6254_2268	COG1373	ATPase (AAA superfamily
B6254_2269	COG1108	ABC-type Mn2 Zn2 transport systems permease components
B6254_2270	COG1121	(ABC) transporter
B6254_2272	COG1846	Transcriptional regulator
B6254_2273	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
B6254_2273	COG2755	lipolytic protein G-D-S-L family
B6254_2274	COG3091	SprT-like family
B6254_2283	COG4975	Glucose uptake
B6254_2284	COG0477	Major facilitator Superfamily
B6254_2285	COG3104	oligopeptide transport
B6254_2295	COG1686	Belongs to the peptidase S11 family
B6254_2297	COG0745	RESPONSE REGULATOR receiver
B6254_2299	COG0012	GTP binding
B6254_2300	COG4481	Protein conserved in bacteria
B6254_2301	COG1475	DNA binding
B6254_2302	COG1192	Involved in chromosome partitioning
B6254_2303	COG0357	Ribosomal RNA small subunit methyltransferase G
B6254_2305	COG1194	a g-specific adenine glycosylase
B6254_2306	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
B6254_2314	COG5002	protein histidine kinase activity
B6254_2315	COG0745	RESPONSE REGULATOR receiver
B6254_2319	COG0318	PFAM AMP-dependent synthetase and ligase
B6254_2320	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
B6254_2321	COG2050	protein possibly involved in aromatic compounds catabolism
B6254_2322	COG1335	isochorismatase
B6254_2323	COG2226	methyltransferase
B6254_2325	COG4443	Transcriptional Coactivator p15 (PC4)
B6254_2326	COG0252	asparaginase activity
B6254_2327	COG0531	amino acid
B6254_2328	COG1113	amino acid transport
B6254_2329	COG0531	amino acid
B6254_2331	COG4975	Glucose uptake
B6254_2332	COG0477	Major facilitator Superfamily
B6254_2334	COG1063	alcohol dehydrogenase
B6254_2335	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
B6254_2337	COG0596	Alpha beta hydrolase
B6254_2338	COG4166	transmembrane transport
B6254_2339	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
B6254_2341	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
B6254_2343	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
B6254_2345	COG3223	Belongs to the PsiE family
B6254_2347	COG0531	amino acid
B6254_2348	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
B6254_2351	COG2070	2-Nitropropane dioxygenase
B6254_2353	COG0583	DNA-binding transcription factor activity
B6254_2355	COG2855	membrane
B6254_2358	COG2855	membrane
B6254_2360	COG0454	-acetyltransferase
B6254_2360	COG0456	acetyltransferase
B6254_2361	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
B6254_2366	COG1113	amino acid transport
B6254_2372	COG0628	permease
B6254_2374	COG0392	lysyltransferase activity
B6254_2374	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
B6254_2376	COG1254	Belongs to the acylphosphatase family
B6254_2377	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B6254_2379	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B6254_2380	COG0765	amino acid transport
B6254_2381	COG1126	abc transporter atp-binding protein
B6254_2383	COG1131	(ABC) transporter
B6254_2385	COG0390	transport system, permease component
B6254_2386	COG4619	ABC transporter
B6254_2388	COG0656	L-ascorbic acid biosynthetic process
B6254_2390	COG1132	(ABC) transporter
B6254_2391	COG1846	Transcriptional regulator
B6254_2395	COG1744	ABC transporter substrate-binding protein PnrA-like
B6254_2396	COG0697	spore germination
B6254_2398	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
B6254_2401	COG0789	Transcriptional regulator
B6254_2403	COG1131	(ABC) transporter
B6254_2407	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
B6254_2408	COG0505	Belongs to the CarA family
B6254_2409	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
B6254_2410	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
B6254_2412	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
B6254_2413	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
B6254_2414	COG0165	Argininosuccinate lyase
B6254_2415	COG0137	argininosuccinate synthase activity
B6254_2416	COG1744	ABC transporter substrate-binding protein PnrA-like
B6254_2418	COG0561	phosphatase activity
B6254_2421	COG0697	spore germination
B6254_2427	COG2723	6-phospho-beta-galactosidase activity
B6254_2428	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
B6254_2428	COG0517	IMP dehydrogenase activity
B6254_2436	COG1881	PFAM PEBP family protein
B6254_2444	COG2252	PERMEase
B6254_2445	COG3152	Membrane
B6254_2449	COG0328	RNA-DNA hybrid ribonuclease activity
B6254_2451	COG0561	phosphatase activity
B6254_2452	COG1033	growth of symbiont in host cell
B6254_2452	COG2409	Drug exporters of the RND superfamily
B6254_2453	COG0577	efflux transmembrane transporter activity
B6254_2454	COG1136	(ABC) transporter
B6254_2456	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
B6254_2457	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
B6254_2459	COG0446	pyridine nucleotide-disulphide oxidoreductase
B6254_2461	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B6254_2465	COG1113	amino acid transport
B6254_2466	COG0569	domain protein
B6254_2469	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
B6254_2471	COG1120	ATPase activity
B6254_2473	COG0706	membrane insertase activity
B6254_2474	COG0594	ribonuclease P activity
B6254_2475	COG0230	Belongs to the bacterial ribosomal protein bL34 family
B6254_2512	COG2026	Addiction module toxin, RelE StbE family
B6254_2526	COG2261	transglycosylase associated protein
B6254_2536	COG2261	transglycosylase associated protein