locus-tag	class	description
K1728_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
K1728_00010	COG0592	DNA-directed DNA polymerase activity
K1728_00015	COG2501	S4 domain
K1728_00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
K1728_00025	COG0187	DNA topoisomerase II activity
K1728_00045	COG1368	sulfuric ester hydrolase activity
K1728_00065	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
K1728_00095	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K1728_00095	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K1728_00105	COG0084	hydrolase, TatD family'
K1728_00110	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
K1728_00115	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
K1728_00120	COG1253	flavin adenine dinucleotide binding
K1728_00125	COG1253	flavin adenine dinucleotide binding
K1728_00130	COG4466	Protein conserved in bacteria
K1728_00135	COG2131	deaminase
K1728_00145	COG1316	TRANSCRIPTIONal
K1728_00150	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
K1728_00155	COG1983	PspC domain protein
K1728_00160	COG1695	Transcriptional regulator
K1728_00175	COG1968	undecaprenyl-diphosphatase activity
K1728_00200	COG3507	Belongs to the glycosyl hydrolase 43 family
K1728_00205	COG2211	Major facilitator Superfamily
K1728_00210	COG1940	carbohydrate kinase activity
K1728_00210	COG1846	Transcriptional regulator
K1728_00215	COG2115	Belongs to the xylose isomerase family
K1728_00230	COG0477	Major facilitator Superfamily
K1728_00235	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
K1728_00250	COG1309	transcriptional regulator
K1728_00255	COG1511	domain protein
K1728_00260	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
K1728_00270	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
K1728_00280	COG0058	SHG alpha-glucan phosphorylase activity
K1728_00285	COG3103	Sh3 type 3 domain protein
K1728_00285	COG0366	Alpha amylase catalytic
K1728_00295	COG0193	aminoacyl-tRNA hydrolase activity
K1728_00300	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
K1728_00305	COG2244	polysaccharide biosynthetic process
K1728_00310	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
K1728_00335	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
K1728_00340	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
K1728_00405	COG2261	transglycosylase associated protein
K1728_00410	COG0656	L-ascorbic acid biosynthetic process
K1728_00420	COG1737	Transcriptional regulator
K1728_00425	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
K1728_00445	COG2910	NAD(P)H-binding
K1728_00450	COG2235	arginine
K1728_00455	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
K1728_00460	COG0531	amino acid
K1728_00485	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
K1728_00500	COG1216	Glycosyl transferase, family 2
K1728_00510	COG1956	GAF domain-containing protein
K1728_00525	COG2233	PERMEase
K1728_00530	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
K1728_00550	COG2084	Dehydrogenase
K1728_00555	COG0438	transferase activity, transferring glycosyl groups
K1728_00795	COG1192	Involved in chromosome partitioning
K1728_00815	COG0542	response to heat
K1728_00855	COG1196	nuclear chromosome segregation
K1728_00855	COG0741	lytic transglycosylase activity
K1728_00855	COG0739	heme binding
K1728_00910	COG1914	H( )-stimulated, divalent metal cation uptake system
K1728_00930	COG0745	RESPONSE REGULATOR receiver
K1728_00935	COG2205	protein histidine kinase activity
K1728_00945	COG1316	TRANSCRIPTIONal
K1728_00950	COG1435	thymidine kinase activity
K1728_00955	COG0604	alcohol dehydrogenase
K1728_00975	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
K1728_00985	COG3639	organic phosphonate transmembrane transporter activity
K1728_00990	COG0737	Belongs to the 5'-nucleotidase family
K1728_00995	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K1728_01005	COG0024	Methionine aminopeptidase
K1728_01015	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
K1728_01035	COG1744	ABC transporter substrate-binding protein PnrA-like
K1728_01040	COG2246	polysaccharide biosynthetic process
K1728_01045	COG1132	(ABC) transporter
K1728_01065	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
K1728_01075	COG0671	phosphoesterase, PA-phosphatase related
K1728_01080	COG0495	leucyl-tRNA aminoacylation
K1728_01085	COG0438	transferase activity, transferring glycosyl groups
K1728_01095	COG2244	polysaccharide biosynthetic process
K1728_01110	COG0626	cystathionine gamma-synthase activity
K1728_01115	COG1902	pentaerythritol trinitrate reductase activity
K1728_01125	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
K1728_01130	COG0531	amino acid
K1728_01135	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K1728_01140	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
K1728_01145	COG1074	ATP-dependent DNA helicase activity
K1728_01150	COG1064	alcohol dehydrogenase
K1728_01155	COG2814	Major facilitator Superfamily
K1728_01160	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
K1728_01170	COG1051	belongs to the nudix hydrolase family
K1728_01175	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
K1728_01185	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
K1728_01195	COG0360	Binds together with S18 to 16S ribosomal RNA
K1728_01200	COG0629	single-stranded DNA binding
K1728_01205	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
K1728_01235	COG0745	RESPONSE REGULATOR receiver
K1728_01240	COG5002	protein histidine kinase activity
K1728_01255	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
K1728_01260	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K1728_01270	COG1078	dGTPase activity
K1728_01275	COG0561	phosphatase activity
K1728_01280	COG3343	RNA polymerase activity
K1728_01300	COG0504	CTP synthase activity
K1728_01305	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
K1728_01315	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
K1728_01320	COG2337	Toxic component of a toxin-antitoxin (TA) module
K1728_01330	COG3973	AAA domain
K1728_01345	COG0673	inositol 2-dehydrogenase activity
K1728_01350	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
K1728_01355	COG2211	Major facilitator Superfamily
K1728_01385	COG1268	BioY protein
K1728_01390	COG0194	GDP metabolic process
K1728_01405	COG1126	abc transporter atp-binding protein
K1728_01410	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K1728_01415	COG0765	amino acid transport
K1728_01420	COG0765	amino acid transport
K1728_01430	COG2814	Major facilitator Superfamily
K1728_01440	COG1609	Transcriptional regulator
K1728_01475	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
K1728_01485	COG1957	nucleoside hydrolase
K1728_01490	COG4166	transmembrane transport
K1728_01495	COG0601	transmembrane transport
K1728_01500	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K1728_01505	COG0444	Belongs to the ABC transporter superfamily
K1728_01510	COG4608	Belongs to the ABC transporter superfamily
K1728_01520	COG0359	binds to the 23S rRNA
K1728_01525	COG0305	Participates in initiation and elongation during chromosome replication
K1728_01530	COG2814	Major facilitator Superfamily
K1728_01565	COG2832	Protein of unknown function (DUF454)
K1728_01575	COG1744	ABC transporter substrate-binding protein PnrA-like
K1728_01580	COG1744	ABC transporter substrate-binding protein PnrA-like
K1728_01595	COG0492	ferredoxin-NADP+ reductase activity
K1728_01600	COG0588	phosphoglycerate mutase activity
K1728_01615	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K1728_01620	COG0628	permease
K1728_01625	COG0640	Transcriptional regulator
K1728_01635	COG0446	pyridine nucleotide-disulphide oxidoreductase
K1728_01640	COG1744	ABC transporter substrate-binding protein PnrA-like
K1728_01645	COG1744	ABC transporter substrate-binding protein PnrA-like
K1728_01650	COG1744	ABC transporter substrate-binding protein PnrA-like
K1728_01655	COG3845	ABC transporter
K1728_01660	COG4603	Belongs to the binding-protein-dependent transport system permease family
K1728_01665	COG1079	Belongs to the binding-protein-dependent transport system permease family
K1728_01675	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
K1728_01680	COG1077	Cell shape determining protein MreB Mrl
K1728_01690	COG0772	Belongs to the SEDS family
K1728_01695	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
K1728_01710	COG0561	phosphatase activity
K1728_01715	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
K1728_01720	COG0561	phosphatase activity
K1728_01730	COG1136	(ABC) transporter
K1728_01730	COG0577	efflux transmembrane transporter activity
K1728_01735	COG1250	3-hydroxyacyl-CoA dehydrogenase
K1728_01745	COG2188	Transcriptional regulator
K1728_01750	COG0582	viral genome integration into host DNA
K1728_01865	COG0629	single-stranded DNA binding
K1728_01890	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
K1728_01955	COG1783	phage Terminase large subunit
K1728_02055	COG5263	repeat protein
K1728_02055	COG5632	N-Acetylmuramoyl-L-alanine amidase
K1728_02070	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
K1728_02075	COG3594	Acyltransferase
K1728_02085	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
K1728_02095	COG0352	thiamine-phosphate diphosphorylase activity
K1728_02100	COG2252	PERMEase
K1728_02110	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
K1728_02115	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
K1728_02130	COG1307	EDD domain protein, DegV family
K1728_02150	COG2814	Major facilitator Superfamily
K1728_02160	COG0656	L-ascorbic acid biosynthetic process
K1728_02205	COG0561	phosphatase activity
K1728_02210	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
K1728_02215	COG4589	Belongs to the CDS family
K1728_02220	COG0750	zinc metalloprotease
K1728_02225	COG0442	prolyl-tRNA aminoacylation
K1728_02230	COG2176	DNA-directed DNA polymerase activity
K1728_02280	COG1131	(ABC) transporter
K1728_02300	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K1728_02345	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
K1728_02355	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
K1728_02360	COG2873	o-acetylhomoserine
K1728_02370	COG2183	response to ionizing radiation
K1728_02385	COG1033	growth of symbiont in host cell
K1728_02385	COG2409	Drug exporters of the RND superfamily
K1728_02400	COG0431	NADPH-dependent FMN reductase
K1728_02410	COG2217	Heavy metal translocating P-type atpase
K1728_02415	COG2814	Major facilitator Superfamily
K1728_02445	COG1609	Transcriptional regulator
K1728_02460	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K1728_02475	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K1728_02475	COG1263	PTS System
K1728_02480	COG2723	6-phospho-beta-galactosidase activity
K1728_02485	COG3759	membrane
K1728_02500	COG1136	(ABC) transporter
K1728_02505	COG0577	efflux transmembrane transporter activity
K1728_02540	COG0561	phosphatase activity
K1728_02560	COG4166	transmembrane transport
K1728_02575	COG1266	CAAX protease self-immunity
K1728_02625	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K1728_02645	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K1728_02645	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K1728_02655	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
K1728_02655	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
K1728_02660	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
K1728_02740	COG0446	pyridine nucleotide-disulphide oxidoreductase
K1728_02745	COG0516	GMP reductase activity
K1728_02750	COG0668	transmembrane transport
K1728_02765	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K1728_02780	COG0402	S-adenosylhomocysteine deaminase activity
K1728_02785	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
K1728_02790	COG0745	RESPONSE REGULATOR receiver
K1728_02795	COG5002	protein histidine kinase activity
K1728_02795	COG3850	Histidine kinase
K1728_02800	COG4975	Glucose uptake
K1728_02810	COG2017	converts alpha-aldose to the beta-anomer
K1728_02820	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
K1728_02825	COG1302	Protein conserved in bacteria
K1728_02835	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
K1728_02840	COG0291	Belongs to the bacterial ribosomal protein bL35 family
K1728_02845	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
K1728_02860	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
K1728_02865	COG0049	tRNA binding
K1728_02870	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
K1728_02880	COG3842	ATPase activity
K1728_02890	COG1177	transmembrane transport
K1728_02900	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
K1728_02910	COG0589	response to stress
K1728_02925	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
K1728_02930	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
K1728_02935	COG1210	Utp--glucose-1-phosphate uridylyltransferase
K1728_02955	COG0492	ferredoxin-NADP+ reductase activity
K1728_02960	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K1728_02970	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
K1728_02975	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
K1728_02980	COG0149	triose-phosphate isomerase activity
K1728_03000	COG2814	Major facilitator Superfamily
K1728_03010	COG0557	exoribonuclease II activity
K1728_03020	COG0765	amino acid transport
K1728_03025	COG1126	abc transporter atp-binding protein
K1728_03030	COG2076	Multidrug Resistance protein
K1728_03035	COG2076	Multidrug Resistance protein
K1728_03050	COG0280	phosphate acetyltransferase
K1728_03055	COG0802	atpase or kinase
K1728_03060	COG0456	acetyltransferase
K1728_03070	COG0812	UDP-N-acetylmuramate dehydrogenase activity
K1728_03085	COG4856	YbbR-like protein
K1728_03090	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K1728_03115	COG0540	Belongs to the ATCase OTCase family
K1728_03125	COG0505	Belongs to the CarA family
K1728_03130	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
K1728_03135	COG0167	dihydroorotate dehydrogenase activity
K1728_03140	COG0284	orotidine-5'-phosphate decarboxylase activity
K1728_03145	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
K1728_03150	COG0438	transferase activity, transferring glycosyl groups
K1728_03155	COG0438	transferase activity, transferring glycosyl groups
K1728_03170	COG1368	sulfuric ester hydrolase activity
K1728_03230	COG1397	ADP-ribosylglycohydrolase
K1728_03240	COG1027	Aspartate ammonia-lyase
K1728_03250	COG3715	PTS system
K1728_03255	COG3716	PTS system mannose fructose sorbose family IID component
K1728_03265	COG0588	phosphoglycerate mutase activity
K1728_03280	COG1696	Membrane protein involved in D-alanine export
K1728_03290	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
K1728_03350	COG0126	phosphoglycerate kinase activity
K1728_03355	COG1811	Na channel or pump
K1728_03360	COG0583	DNA-binding transcription factor activity
K1728_03365	COG1132	(ABC) transporter
K1728_03370	COG1132	(ABC) transporter
K1728_03375	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K1728_03395	COG3760	aminoacyl-tRNA metabolism involved in translational fidelity
K1728_03410	COG1113	amino acid transport
K1728_03415	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
K1728_03450	COG1757	Na H antiporter
K1728_03455	COG0328	RNA-DNA hybrid ribonuclease activity
K1728_03465	COG0564	pseudouridine synthase activity
K1728_03475	COG0505	Belongs to the CarA family
K1728_03485	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K1728_03490	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
K1728_03500	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
K1728_03505	COG1846	Transcriptional regulator
K1728_03510	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K1728_03515	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K1728_03520	COG2070	2-Nitropropane dioxygenase
K1728_03525	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
K1728_03530	COG1028	Short-chain dehydrogenase reductase Sdr
K1728_03535	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K1728_03550	COG0439	Biotin carboxylase
K1728_03555	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
K1728_03565	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
K1728_03580	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K1728_03585	COG4115	mRNA cleavage
K1728_03590	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
K1728_03595	COG1704	LemA family
K1728_03600	COG0501	Belongs to the peptidase M48B family
K1728_03605	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
K1728_03610	COG0673	inositol 2-dehydrogenase activity
K1728_03615	COG0513	Belongs to the DEAD box helicase family
K1728_03620	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
K1728_03640	COG0083	homoserine kinase activity
K1728_03645	COG1609	Transcriptional regulator
K1728_03655	COG0527	aspartate kinase activity
K1728_03660	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
K1728_03670	COG2171	N-acyltransferase activity
K1728_03675	COG1473	amidohydrolase
K1728_03680	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K1728_03685	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
K1728_03690	COG0436	Aminotransferase
K1728_03695	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
K1728_03710	COG0596	Alpha beta hydrolase
K1728_03720	COG0436	Aminotransferase
K1728_03730	COG2188	Transcriptional regulator
K1728_03735	COG1131	(ABC) transporter
K1728_03750	COG1136	(ABC) transporter
K1728_03755	COG1136	(ABC) transporter
K1728_03755	COG0577	efflux transmembrane transporter activity
K1728_03760	COG1609	Transcriptional regulator
K1728_03780	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K1728_03785	COG4684	Psort location CytoplasmicMembrane, score
K1728_03800	COG0438	transferase activity, transferring glycosyl groups
K1728_03825	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
K1728_03830	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
K1728_03835	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
K1728_03840	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
K1728_03845	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
K1728_03850	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
K1728_03855	COG0710	3-dehydroquinate dehydratase activity
K1728_03865	COG2115	Belongs to the xylose isomerase family
K1728_03875	COG1122	ATPase activity
K1728_03885	COG0167	dihydroorotate dehydrogenase activity
K1728_03890	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
K1728_03895	COG0667	Aldo Keto reductase
K1728_03915	COG0456	acetyltransferase
K1728_03920	COG1914	H( )-stimulated, divalent metal cation uptake system
K1728_03955	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
K1728_03955	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
K1728_03960	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
K1728_03970	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
K1728_03975	COG1597	lipid kinase activity
K1728_03985	COG2315	Protein conserved in bacteria
K1728_03995	COG1108	ABC-type Mn2 Zn2 transport systems permease components
K1728_04000	COG1121	(ABC) transporter
K1728_04010	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
K1728_04025	COG0018	arginyl-trna synthetase
K1728_04030	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
K1728_04035	COG0519	Catalyzes the synthesis of GMP from XMP
K1728_04050	COG0306	phosphate transporter
K1728_04055	COG1438	arginine binding
K1728_04060	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K1728_04065	COG3679	Belongs to the UPF0342 family
K1728_04070	COG0420	3'-5' exonuclease activity
K1728_04075	COG4717	serine-type aminopeptidase activity
K1728_04100	COG1070	Carbohydrate kinase
K1728_04120	COG0612	Peptidase, M16
K1728_04125	COG0612	Peptidase, M16
K1728_04130	COG1426	Protein conserved in bacteria
K1728_04135	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
K1728_04140	COG1058	Belongs to the CinA family
K1728_04140	COG1546	Belongs to the CinA family
K1728_04145	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
K1728_04155	COG3973	AAA domain
K1728_04165	COG0741	lytic transglycosylase activity
K1728_04180	COG1278	Cold shock
K1728_04185	COG0564	pseudouridine synthase activity
K1728_04275	COG2309	aminopeptidase activity
K1728_04300	COG2235	arginine
K1728_04305	COG3835	regulator
K1728_04310	COG2246	polysaccharide biosynthetic process
K1728_04320	COG0024	Methionine aminopeptidase
K1728_04335	COG0791	NLP P60 protein
K1728_04335	COG3883	PFAM NLP P60 protein
K1728_04350	COG1442	glycosyl transferase family 8
K1728_04355	COG1215	transferase activity, transferring glycosyl groups
K1728_04355	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
K1728_04370	COG0438	transferase activity, transferring glycosyl groups
K1728_04395	COG1134	teichoic acid transport
K1728_04395	COG1388	LysM domain
K1728_04400	COG1682	transport, permease protein
K1728_04405	COG1216	Glycosyl transferase, family 2
K1728_04410	COG0562	UDP-galactopyranose mutase
K1728_04420	COG0463	Glycosyl transferase, family 2
K1728_04425	COG1388	LysM domain
K1728_04425	COG1705	Flagellar rod assembly protein muramidase FlgJ
K1728_04465	COG1420	regulation of RNA biosynthetic process
K1728_04475	COG0443	Heat shock 70 kDa protein
K1728_04480	COG0484	heat shock protein binding
K1728_04500	COG1234	tRNA 3'-trailer cleavage
K1728_04505	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
K1728_04505	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
K1728_04515	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
K1728_04520	COG4224	UPF0291 protein
K1728_04525	COG3763	UPF0154 protein
K1728_04535	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
K1728_04550	COG0204	Acyl-transferase
K1728_04555	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
K1728_04560	COG2827	Endonuclease containing a URI domain
K1728_04575	COG0741	lytic transglycosylase activity
K1728_04590	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
K1728_04600	COG0233	cytoplasmic translational termination
K1728_04605	COG0004	ammonium transporteR
K1728_04610	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
K1728_04625	COG0617	tRNA 3'-terminal CCA addition
K1728_04630	COG0488	(ABC) transporter
K1728_04635	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
K1728_04645	COG0587	DNA-directed DNA polymerase activity
K1728_04650	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K1728_04655	COG1490	D-aminoacyl-tRNA deacylase activity
K1728_04665	COG0475	glutathione-regulated potassium exporter activity
K1728_04680	COG2996	Protein conserved in bacteria
K1728_04695	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
K1728_04700	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
K1728_04705	COG1187	pseudouridine synthase activity
K1728_04720	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
K1728_04730	COG0514	ATP-dependent DNA helicase (RecQ)
K1728_04740	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
K1728_04745	COG0539	negative regulation of cytoplasmic translation
K1728_04750	COG1160	GTP binding
K1728_04760	COG0351	phosphomethylpyrimidine kinase
K1728_04765	COG4720	Psort location CytoplasmicMembrane, score
K1728_04770	COG2807	transmembrane transport
K1728_04780	COG0420	3'-5' exonuclease activity
K1728_04785	COG0419	ATPase involved in DNA repair
K1728_04860	COG0071	Belongs to the small heat shock protein (HSP20) family
K1728_04865	COG2384	SAM-dependent methyltransferase
K1728_04870	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
K1728_04880	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
K1728_04890	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
K1728_04915	COG2357	RelA SpoT domain protein
K1728_04925	COG1464	Belongs to the NlpA lipoprotein family
K1728_04930	COG0267	Belongs to the bacterial ribosomal protein bL33 family
K1728_04935	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
K1728_04940	COG0028	Belongs to the TPP enzyme family
K1728_04945	COG2207	Transcriptional regulator
K1728_04945	COG1917	Cupin 2, conserved barrel domain protein
K1728_04950	COG2190	(PTS) system
K1728_04950	COG2211	Major facilitator Superfamily
K1728_04955	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
K1728_04960	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
K1728_04980	COG1695	Transcriptional regulator
K1728_04985	COG3620	sequence-specific DNA binding
K1728_05015	COG1304	FMN binding
K1728_05035	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
K1728_05035	COG1199	ATP-dependent helicase activity
K1728_05040	COG5353	protein conserved in bacteria
K1728_05045	COG0017	Asparaginyl-tRNA synthetase
K1728_05070	COG3935	DnaD domain protein
K1728_05080	COG3331	DNA recombination
K1728_05085	COG4474	Belongs to the UPF0398 family
K1728_05090	COG3599	regulation of cell shape
K1728_05100	COG0116	Belongs to the methyltransferase superfamily
K1728_05110	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
K1728_05125	COG0556	nucleotide-excision repair
K1728_05135	COG0439	Biotin carboxylase
K1728_05140	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
K1728_05145	COG0825	malonyl-CoA metabolic process
K1728_05150	COG2272	Belongs to the type-B carboxylesterase lipase family
K1728_05160	COG2723	6-phospho-beta-galactosidase activity
K1728_05165	COG0363	glucosamine-6-phosphate deaminase activity
K1728_05170	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K1728_05185	COG1304	FMN binding
K1728_05195	COG3104	oligopeptide transport
K1728_05200	COG0363	glucosamine-6-phosphate deaminase activity
K1728_05210	COG0537	adenosine 5'-monophosphoramidase activity
K1728_05215	COG1131	(ABC) transporter
K1728_05225	COG0220	tRNA (guanine-N7-)-methyltransferase activity
K1728_05230	COG1719	4-vinyl reductase, 4VR
K1728_05350	COG0433	COG0433 Predicted ATPase
K1728_05360	COG1674	ftsk spoiiie
K1728_05370	COG2946	Replication initiation factor
K1728_05375	COG2826	transposase and inactivated derivatives, IS30 family
K1728_05385	COG1674	ftsk spoiiie
K1728_05450	COG0433	COG0433 Predicted ATPase
K1728_05490	COG3942	CHAP domain
K1728_05490	COG1705	Flagellar rod assembly protein muramidase FlgJ
K1728_05525	COG2826	transposase and inactivated derivatives, IS30 family
K1728_05535	COG2826	transposase and inactivated derivatives, IS30 family
K1728_05580	COG0739	heme binding
K1728_05580	COG1196	nuclear chromosome segregation
K1728_05580	COG0741	lytic transglycosylase activity
K1728_05620	COG0542	response to heat
K1728_05640	COG1192	Involved in chromosome partitioning
K1728_05675	COG2337	Toxic component of a toxin-antitoxin (TA) module
K1728_05795	COG2826	transposase and inactivated derivatives, IS30 family
K1728_05805	COG3237	CsbD-like
K1728_05835	COG3064	Membrane
K1728_05835	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
K1728_05935	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K1728_05940	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
K1728_05950	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K1728_05955	COG2814	Major facilitator Superfamily
K1728_06070	COG1914	H( )-stimulated, divalent metal cation uptake system
K1728_06075	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
K1728_06085	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K1728_06110	COG0531	amino acid
K1728_06120	COG0481	GTPase activity
K1728_06135	COG1028	Short-chain dehydrogenase reductase Sdr
K1728_06140	COG4708	membrane
K1728_06150	COG0531	amino acid
K1728_06155	COG4221	oxidoreductase activity
K1728_06160	COG0583	DNA-binding transcription factor activity
K1728_06165	COG0281	malic enzyme
K1728_06180	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K1728_06190	COG2076	Multidrug Resistance protein
K1728_06195	COG2076	Multidrug Resistance protein
K1728_06200	COG1136	(ABC) transporter
K1728_06205	COG0577	efflux transmembrane transporter activity
K1728_06220	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
K1728_06230	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K1728_06235	COG1028	Short-chain dehydrogenase reductase Sdr
K1728_06240	COG0706	membrane insertase activity
K1728_06255	COG1942	4-Oxalocrotonate Tautomerase
K1728_06275	COG5002	protein histidine kinase activity
K1728_06280	COG0745	RESPONSE REGULATOR receiver
K1728_06295	COG1484	DNA-dependent DNA replication
K1728_06310	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
K1728_06315	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K1728_06315	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K1728_06325	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
K1728_06335	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K1728_06340	COG1363	Peptidase, m42
K1728_06345	COG0572	uridine kinase
K1728_06350	COG5002	protein histidine kinase activity
K1728_06355	COG0745	RESPONSE REGULATOR receiver
K1728_06380	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
K1728_06385	COG0358	DNA primase activity
K1728_06390	COG2826	transposase and inactivated derivatives, IS30 family
K1728_06395	COG1192	Involved in chromosome partitioning
K1728_06535	COG0542	response to heat
K1728_06550	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
K1728_06550	COG0551	DNA topoisomerase type I activity
K1728_06565	COG0776	regulation of translation
K1728_06645	COG0477	Major facilitator Superfamily
K1728_06650	COG0105	UTP biosynthetic process
K1728_06655	COG3480	Lon protease (S16) C-terminal proteolytic domain
K1728_06660	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
K1728_06665	COG0742	ribosomal rna small subunit methyltransferase
K1728_06670	COG4471	UPF0298 protein
K1728_06675	COG0772	Belongs to the SEDS family
K1728_06680	COG1217	gtp-binding protein TYPA
K1728_06685	COG0483	inositol monophosphate 1-phosphatase activity
K1728_06690	COG4476	Belongs to the UPF0223 family
K1728_06695	COG0242	peptide deformylase activity
K1728_06710	COG5503	Protein of unknown function (DUF1447)
K1728_06725	COG1011	Hydrolase
K1728_06730	COG1597	lipid kinase activity
K1728_06735	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K1728_06740	COG1464	Belongs to the NlpA lipoprotein family
K1728_06745	COG0446	pyridine nucleotide-disulphide oxidoreductase
K1728_06755	COG4175	Glycine betaine
K1728_06755	COG3448	diguanylate cyclase activity
K1728_06775	COG0187	DNA topoisomerase II activity
K1728_06780	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
K1728_06790	COG4974	Belongs to the 'phage' integrase family
K1728_06795	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
K1728_06800	COG0758	DNA mediated transformation
K1728_06805	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
K1728_06815	COG4479	Belongs to the UPF0346 family
K1728_06825	COG2755	lipolytic protein G-D-S-L family
K1728_06830	COG1307	EDD domain protein, DegV family
K1728_06835	COG1307	EDD domain protein, DegV family
K1728_06840	COG2270	Major facilitator Superfamily
K1728_06855	COG3142	Participates in the control of copper homeostasis
K1728_06860	COG1293	RNA-binding protein homologous to eukaryotic snRNP
K1728_06865	COG0196	riboflavin kinase activity
K1728_06880	COG1252	NADH dehydrogenase
K1728_06885	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
K1728_06890	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
K1728_06895	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
K1728_06905	COG2740	Nucleic-acid-binding protein implicated in transcription termination
K1728_06910	COG0195	Participates in both transcription termination and antitermination
K1728_06915	COG0779	Required for maturation of 30S ribosomal subunits
K1728_06925	COG1304	FMN binding
K1728_06930	COG2814	Major facilitator Superfamily
K1728_06950	COG0277	FAD linked oxidase domain protein
K1728_06960	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
K1728_06965	COG0738	Major facilitator superfamily
K1728_06970	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
K1728_06980	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
K1728_07010	COG0697	spore germination
K1728_07020	COG2223	nitrite transmembrane transporter activity
K1728_07025	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K1728_07025	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K1728_07025	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
K1728_07030	COG1105	Belongs to the carbohydrate kinase PfkB family
K1728_07035	COG1349	DNA-binding transcription factor activity
K1728_07040	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
K1728_07045	COG1940	carbohydrate kinase activity
K1728_07060	COG2723	6-phospho-beta-galactosidase activity
K1728_07065	COG1737	Transcriptional regulator
K1728_07110	COG1309	transcriptional regulator
K1728_07115	COG0456	acetyltransferase
K1728_07120	COG1846	Transcriptional regulator
K1728_07135	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
K1728_07140	COG0656	L-ascorbic acid biosynthetic process
K1728_07165	COG0446	pyridine nucleotide-disulphide oxidoreductase
K1728_07180	COG0488	(ABC) transporter
K1728_07195	COG2315	Protein conserved in bacteria
K1728_07210	COG4221	oxidoreductase activity
K1728_07235	COG0738	Major facilitator superfamily
K1728_07240	COG1869	D-ribose catabolic process
K1728_07265	COG1131	(ABC) transporter
K1728_07270	COG2814	Major facilitator Superfamily
K1728_07275	COG2239	Acts as a magnesium transporter
K1728_07280	COG0564	pseudouridine synthase activity
K1728_07285	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
K1728_07290	COG2357	RelA SpoT domain protein
K1728_07305	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
K1728_07310	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
K1728_07395	COG0352	thiamine-phosphate diphosphorylase activity
K1728_07400	COG0351	phosphomethylpyrimidine kinase
K1728_07405	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
K1728_07430	COG2723	6-phospho-beta-galactosidase activity
K1728_07485	COG2856	Zn peptidase
K1728_07525	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
K1728_07555	COG1609	Transcriptional regulator
K1728_07560	COG1621	beta-fructofuranosidase activity
K1728_07580	COG0681	Belongs to the peptidase S26 family
K1728_07600	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
K1728_07635	COG0308	aminopeptidase N
K1728_07705	COG0395	ABC-type sugar transport system, permease component
K1728_07710	COG1175	transmembrane transport
K1728_07720	COG0737	Belongs to the 5'-nucleotidase family
K1728_07730	COG2160	L-arabinose isomerase activity
K1728_07750	COG3940	Belongs to the glycosyl hydrolase 43 family
K1728_07765	COG0656	L-ascorbic acid biosynthetic process
K1728_07770	COG2160	L-arabinose isomerase activity
K1728_07790	COG3118	belongs to the thioredoxin family
K1728_07810	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
K1728_07820	COG1215	transferase activity, transferring glycosyl groups
K1728_07840	COG1193	negative regulation of DNA recombination
K1728_07860	COG4166	transmembrane transport
K1728_07865	COG0218	Necessary for normal cell division and for the maintenance of normal septation
K1728_07870	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
K1728_07915	COG0268	Binds directly to 16S ribosomal RNA
K1728_07920	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
K1728_07925	COG1466	dna polymerase III delta subunit
K1728_07930	COG0658	competence protein
K1728_07930	COG2333	competence protein COMEC
K1728_07935	COG1555	photosystem II stabilization
K1728_07935	COG1596	polysaccharide export
K1728_07940	COG3906	Belongs to the UPF0473 family
K1728_07945	COG3906	Belongs to the UPF0473 family
K1728_07960	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
K1728_07965	COG1929	Belongs to the glycerate kinase type-1 family
K1728_07980	COG0513	Belongs to the DEAD box helicase family
K1728_07985	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
K1728_07990	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
K1728_07995	COG1862	Preprotein translocase
K1728_08000	COG0343	queuine tRNA-ribosyltransferase activity
K1728_08035	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
K1728_08040	COG2255	four-way junction helicase activity
K1728_08045	COG0632	four-way junction helicase activity
K1728_08050	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
K1728_08055	COG0517	IMP dehydrogenase activity
K1728_08055	COG0516	GMP reductase activity
K1728_08060	COG0516	GMP reductase activity
K1728_08060	COG0517	IMP dehydrogenase activity
K1728_08065	COG2814	Major facilitator Superfamily
K1728_08075	COG1739	Uncharacterized protein family UPF0029
K1728_08085	COG0322	excinuclease ABC activity
K1728_08100	COG1668	transmembrane transport
K1728_08105	COG4152	abc transporter atp-binding protein
K1728_08115	COG1674	ftsk spoiiie
K1728_08125	COG0628	permease
K1728_08130	COG2706	6-phosphogluconolactonase activity
K1728_08150	COG0751	glycine-tRNA ligase activity
K1728_08155	COG0752	glycyl-tRNA synthetase alpha subunit
K1728_08170	COG1381	Involved in DNA repair and RecF pathway recombination
K1728_08175	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
K1728_08180	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
K1728_08185	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
K1728_08190	COG1702	phosphate starvation-inducible protein PhoH
K1728_08195	COG1610	YqeY-like protein
K1728_08200	COG0828	Belongs to the bacterial ribosomal protein bS21 family
K1728_08205	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K1728_08215	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
K1728_08220	COG0124	histidyl-tRNA synthetase
K1728_08245	COG3425	synthase
K1728_08250	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
K1728_08325	COG0006	proline dipeptidase activity
K1728_08330	COG1609	Transcriptional regulator
K1728_08345	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
K1728_08350	COG1164	Oligoendopeptidase f
K1728_08360	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
K1728_08365	COG2723	6-phospho-beta-galactosidase activity
K1728_08370	COG1447	Phosphotransferase system cellobiose-specific component IIA
K1728_08375	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
K1728_08380	COG2723	6-phospho-beta-galactosidase activity
K1728_08385	COG4862	establishment of competence for transformation
K1728_08390	COG1393	Belongs to the ArsC family
K1728_08395	COG3853	Toxic anion resistance protein (TelA)
K1728_08445	COG0561	phosphatase activity
K1728_08450	COG1970	mechanosensitive ion channel activity
K1728_08455	COG1428	Deoxynucleoside kinase
K1728_08470	COG1942	4-Oxalocrotonate Tautomerase
K1728_08475	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K1728_08490	COG0336	Belongs to the RNA methyltransferase TrmD family
K1728_08495	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
K1728_08500	COG0588	phosphoglycerate mutase activity
K1728_08510	COG0228	four-way junction DNA binding
K1728_08530	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
K1728_08535	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
K1728_08540	COG0552	protein localization to endoplasmic reticulum
K1728_08545	COG1196	nuclear chromosome segregation
K1728_08550	COG0571	ribonuclease III activity
K1728_08555	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K1728_08560	COG0416	fatty acid biosynthetic process
K1728_08565	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
K1728_08570	COG2211	Major facilitator Superfamily
K1728_08590	COG1461	Dihydroxyacetone kinase
K1728_08600	COG0227	Belongs to the bacterial ribosomal protein bL28 family
K1728_08605	COG1564	THIamine pyrophosphokinase
K1728_08610	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
K1728_08615	COG1162	GTPase activity
K1728_08620	COG2815	serine threonine protein kinase
K1728_08620	COG0515	serine threonine protein kinase
K1728_08630	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
K1728_08630	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
K1728_08635	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
K1728_08640	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
K1728_08665	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
K1728_08705	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K1728_08710	COG2252	PERMEase
K1728_08715	COG0217	transcriptional regulatory protein
K1728_08720	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
K1728_08730	COG0406	alpha-ribazole phosphatase activity
K1728_08740	COG3599	regulation of cell shape
K1728_08755	COG1799	cell septum assembly
K1728_08765	COG0849	cell division
K1728_08770	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
K1728_08775	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
K1728_08780	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
K1728_08785	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K1728_08790	COG0768	penicillin binding
K1728_08800	COG0275	rRNA processing
K1728_08805	COG2001	Belongs to the MraZ family
K1728_08815	COG1385	rRNA (uridine-N3-)-methyltransferase activity
K1728_08820	COG2264	protein methyltransferase activity
K1728_08830	COG0833	amino acid
K1728_08845	COG2759	Belongs to the formate--tetrahydrofolate ligase family
K1728_08850	COG0151	Belongs to the GarS family
K1728_08855	COG0138	bifunctional purine biosynthesis protein purh
K1728_08860	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
K1728_08875	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
K1728_08880	COG0047	phosphoribosylformylglycinamidine synthase activity
K1728_08885	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
K1728_08895	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
K1728_08900	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
K1728_08905	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
K1728_08905	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
K1728_08910	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K1728_08915	COG1126	abc transporter atp-binding protein
K1728_08920	COG0765	amino acid transport
K1728_08940	COG1077	Cell shape determining protein MreB Mrl
K1728_08945	COG2003	Belongs to the UPF0758 family
K1728_08960	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K1728_08960	COG2190	(PTS) system
K1728_08960	COG1263	PTS System
K1728_08965	COG1307	EDD domain protein, DegV family
K1728_08970	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
K1728_08975	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
K1728_08980	COG0038	chloride channel
K1728_08990	COG4120	Belongs to the binding-protein-dependent transport system permease family
K1728_09005	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K1728_09010	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
K1728_09030	COG0741	lytic transglycosylase activity
K1728_09045	COG0346	lactoylglutathione lyase activity
K1728_09050	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
K1728_09060	COG0494	nUDIX hydrolase
K1728_09065	COG1278	Cold shock
K1728_09085	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
K1728_09090	COG1705	Flagellar rod assembly protein muramidase FlgJ
K1728_09095	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
K1728_09100	COG4988	ABC transporter
K1728_09105	COG1294	oxidase, subunit
K1728_09110	COG1271	oxidase subunit
K1728_09115	COG4684	Psort location CytoplasmicMembrane, score
K1728_09130	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K1728_09240	COG1098	S1 RNA binding domain
K1728_09250	COG0586	Pfam SNARE associated Golgi protein
K1728_09255	COG1758	RNA polymerase activity
K1728_09260	COG0194	GDP metabolic process
K1728_09270	COG0497	DNA recombination
K1728_09275	COG1438	arginine binding
K1728_09280	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
K1728_09285	COG0142	geranyltranstransferase activity
K1728_09300	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
K1728_09305	COG4720	Psort location CytoplasmicMembrane, score
K1728_09320	COG1136	(ABC) transporter
K1728_09325	COG0577	efflux transmembrane transporter activity
K1728_09340	COG0363	glucosamine-6-phosphate deaminase activity
K1728_09345	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
K1728_09370	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
K1728_09375	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
K1728_09385	COG1323	Belongs to the UPF0348 family
K1728_09390	COG2226	methyltransferase
K1728_09395	COG0799	negative regulation of ribosome biogenesis
K1728_09400	COG1713	HD superfamily hydrolase involved in NAD metabolism
K1728_09405	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
K1728_09415	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
K1728_09420	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
K1728_09425	COG1181	Belongs to the D-alanine--D-alanine ligase family
K1728_09435	COG0531	amino acid
K1728_09440	COG0459	protein refolding
K1728_09445	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
K1728_09455	COG2814	Major facilitator Superfamily
K1728_09460	COG0488	(ABC) transporter
K1728_09475	COG0285	dihydrofolate synthase activity
K1728_09480	COG0525	valine-tRNA ligase activity
K1728_09495	COG1272	protein, Hemolysin III
K1728_09525	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
K1728_09540	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
K1728_09555	COG2137	regulation of response to DNA damage stimulus
K1728_09560	COG0704	Plays a role in the regulation of phosphate uptake
K1728_09565	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
K1728_09570	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
K1728_09575	COG0581	inorganic phosphate transmembrane transporter activity
K1728_09580	COG0573	inorganic phosphate transmembrane transporter activity
K1728_09600	COG1957	nucleoside hydrolase
K1728_09605	COG0673	inositol 2-dehydrogenase activity
K1728_09610	COG4166	transmembrane transport
K1728_09615	COG0647	UMP catabolic process
K1728_09620	COG4470	Protein conserved in bacteria
K1728_09640	COG0006	proline dipeptidase activity
K1728_09645	COG4948	Mandelate Racemase Muconate Lactonizing
K1728_09650	COG0596	Alpha beta hydrolase
K1728_09655	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
K1728_09660	COG1169	isochorismate synthase
K1728_09665	COG1132	(ABC) transporter
K1728_09680	COG1472	Belongs to the glycosyl hydrolase 3 family
K1728_09695	COG0211	Belongs to the bacterial ribosomal protein bL27 family
K1728_09700	COG0261	This protein binds to 23S rRNA in the presence of protein L20
K1728_09725	COG0174	glutamine synthetase
K1728_09730	COG0789	Transcriptional regulator
K1728_09735	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
K1728_09750	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K1728_09755	COG4942	peptidase
K1728_09765	COG1940	carbohydrate kinase activity
K1728_09780	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
K1728_09785	COG0768	penicillin binding
K1728_09795	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K1728_09800	COG0514	ATP-dependent DNA helicase (RecQ)
K1728_09805	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
K1728_09810	COG0072	phenylalanine-tRNA ligase activity
K1728_09810	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K1728_09815	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
K1728_09820	COG1733	regulation of RNA biosynthetic process
K1728_09845	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K1728_09870	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
K1728_09880	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
K1728_09885	COG0653	protein targeting
K1728_09895	COG4956	integral membrane protein (PIN domain superfamily)
K1728_09905	COG0756	dUTP diphosphatase activity
K1728_09920	COG1388	LysM domain
K1728_09920	COG0791	NLP P60 protein
K1728_09930	COG3527	Alpha-acetolactate decarboxylase
K1728_09935	COG0028	Belongs to the TPP enzyme family
K1728_09940	COG0039	L-malate dehydrogenase activity
K1728_09955	COG1215	transferase activity, transferring glycosyl groups
K1728_09965	COG2514	catechol 2,3-dioxygenase activity
K1728_10040	COG4974	Belongs to the 'phage' integrase family
K1728_10090	COG4974	Belongs to the 'phage' integrase family
K1728_10110	COG1914	H( )-stimulated, divalent metal cation uptake system
K1728_10120	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K1728_10120	COG2190	(PTS) system
K1728_10120	COG1263	PTS System
K1728_10135	COG0740	serine-type endopeptidase activity
K1728_10140	COG1481	regulation of sporulation
K1728_10145	COG0391	Required for morphogenesis under gluconeogenic growth conditions
K1728_10160	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
K1728_10165	COG2814	Major facilitator Superfamily
K1728_10175	COG0671	phosphoesterase, PA-phosphatase related
K1728_10190	COG0366	Alpha amylase catalytic
K1728_10200	COG1573	uracil-dna glycosylase
K1728_10205	COG0028	Belongs to the TPP enzyme family
K1728_10215	COG2814	Major facilitator Superfamily
K1728_10235	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
K1728_10240	COG0101	tRNA pseudouridine synthase activity
K1728_10250	COG1122	ATPase activity
K1728_10255	COG1122	ATPase activity
K1728_10265	COG1252	NADH dehydrogenase
K1728_10270	COG0803	Belongs to the bacterial solute-binding protein 9 family
K1728_10275	COG1108	ABC-type Mn2 Zn2 transport systems permease components
K1728_10280	COG1121	(ABC) transporter
K1728_10290	COG0222	ribosome binding
K1728_10295	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
K1728_10300	COG0081	regulation of translation
K1728_10305	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
K1728_10310	COG0250	Participates in transcription elongation, termination and antitermination
K1728_10315	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
K1728_10320	COG0267	Belongs to the bacterial ribosomal protein bL33 family
K1728_10330	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K1728_10335	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
K1728_10340	COG1854	S-ribosylhomocysteine lyase activity
K1728_10345	COG1464	Belongs to the NlpA lipoprotein family
K1728_10350	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
K1728_10360	COG0215	cysteine-tRNA ligase activity
K1728_10375	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K1728_10385	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
K1728_10400	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
K1728_10430	COG0203	ribosomal protein L17
K1728_10435	COG0202	RNA polymerase activity
K1728_10440	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
K1728_10445	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
K1728_10450	COG0257	Belongs to the bacterial ribosomal protein bL36 family
K1728_10455	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
K1728_10470	COG0200	Binds to the 23S rRNA
K1728_10475	COG1841	ribosomal large subunit assembly
K1728_10480	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
K1728_10485	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
K1728_10490	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
K1728_10495	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
K1728_10500	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
K1728_10505	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
K1728_10510	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
K1728_10520	COG0255	Belongs to the universal ribosomal protein uL29 family
K1728_10525	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
K1728_10530	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
K1728_10535	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
K1728_10540	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
K1728_10545	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
K1728_10550	COG0089	rRNA binding
K1728_10560	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
K1728_10565	COG0051	transcription antitermination factor activity, RNA binding
K1728_10575	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
K1728_10590	COG1214	PFAM Peptidase M22, glycoprotease
K1728_10605	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
K1728_10625	COG3870	Protein conserved in bacteria
K1728_10630	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
K1728_10645	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
K1728_10655	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
K1728_10670	COG2813	Specifically methylates the guanine in position
K1728_10680	COG2807	transmembrane transport
K1728_10715	COG0500	methyltransferase
K1728_10735	COG1979	alcohol dehydrogenase
K1728_10745	COG0085	RNA polymerase activity
K1728_10750	COG0542	response to heat
K1728_10755	COG4463	regulation of RNA biosynthetic process
K1728_10780	COG1686	Belongs to the peptidase S11 family
K1728_10785	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
K1728_10790	COG1428	Deoxynucleoside kinase
K1728_10795	COG1876	peptidase activity
K1728_10800	COG0355	proton-transporting ATP synthase activity, rotational mechanism
K1728_10805	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
K1728_10810	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
K1728_10815	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
K1728_10820	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
K1728_10825	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
K1728_10830	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
K1728_10835	COG0356	it plays a direct role in the translocation of protons across the membrane
K1728_10840	COG2233	PERMEase
K1728_10845	COG0702	epimerase
K1728_10850	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
K1728_10855	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
K1728_10860	COG0009	L-threonylcarbamoyladenylate synthase
K1728_10865	COG2890	protein-(glutamine-N5) methyltransferase activity
K1728_10875	COG1435	thymidine kinase activity
K1728_10885	COG3442	glutamine amidotransferase
K1728_10890	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
K1728_10905	COG1482	cell wall glycoprotein biosynthetic process
K1728_10930	COG1132	(ABC) transporter
K1728_10935	COG1132	(ABC) transporter
K1728_10945	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
K1728_10950	COG0588	phosphoglycerate mutase activity
K1728_10970	COG1131	(ABC) transporter
K1728_10975	COG0708	Exodeoxyribonuclease III
K1728_10990	COG1454	alcohol dehydrogenase
K1728_10990	COG1012	belongs to the aldehyde dehydrogenase family
K1728_11000	COG3590	peptidase
K1728_11035	COG5039	Polysaccharide pyruvyl transferase
K1728_11040	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
K1728_11045	COG2188	Transcriptional regulator
K1728_11070	COG2814	Major facilitator Superfamily
K1728_11075	COG1418	mRNA catabolic process
K1728_11110	COG0765	amino acid transport
K1728_11145	COG0534	Mate efflux family protein
K1728_11150	COG0488	(ABC) transporter
K1728_11160	COG1121	(ABC) transporter
K1728_11170	COG1846	Transcriptional regulator
K1728_11175	COG2755	lipolytic protein G-D-S-L family
K1728_11175	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
K1728_11180	COG1979	alcohol dehydrogenase
K1728_11185	COG3091	SprT-like family
K1728_11220	COG0477	Major facilitator Superfamily
K1728_11225	COG3104	oligopeptide transport
K1728_11275	COG1686	Belongs to the peptidase S11 family
K1728_11285	COG0745	RESPONSE REGULATOR receiver
K1728_11295	COG0012	GTP binding
K1728_11300	COG4481	Protein conserved in bacteria
K1728_11305	COG1475	DNA binding
K1728_11310	COG1192	Involved in chromosome partitioning
K1728_11315	COG0357	Ribosomal RNA small subunit methyltransferase G
K1728_11320	COG1957	nucleoside hydrolase
K1728_11325	COG1194	a g-specific adenine glycosylase
K1728_11340	COG1511	domain protein
K1728_11350	COG2207	Transcriptional regulator
K1728_11365	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
K1728_11370	COG5002	protein histidine kinase activity
K1728_11375	COG0745	RESPONSE REGULATOR receiver
K1728_11390	COG0318	PFAM AMP-dependent synthetase and ligase
K1728_11395	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
K1728_11400	COG2050	protein possibly involved in aromatic compounds catabolism
K1728_11405	COG1335	isochorismatase
K1728_11410	COG2226	methyltransferase
K1728_11420	COG4443	Transcriptional Coactivator p15 (PC4)
K1728_11425	COG0252	asparaginase activity
K1728_11430	COG0531	amino acid
K1728_11435	COG1113	amino acid transport
K1728_11465	COG0531	amino acid
K1728_11475	COG0477	Major facilitator Superfamily
K1728_11485	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
K1728_11490	COG1063	alcohol dehydrogenase
K1728_11495	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
K1728_11505	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
K1728_11515	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
K1728_11530	COG4975	Glucose uptake
K1728_11540	COG0531	amino acid
K1728_11545	COG1228	amidohydrolase
K1728_11565	COG2855	membrane
K1728_11575	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K1728_11600	COG1113	amino acid transport
K1728_11630	COG0628	permease
K1728_11640	COG0392	lysyltransferase activity
K1728_11640	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
K1728_11650	COG1254	Belongs to the acylphosphatase family
K1728_11655	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K1728_11660	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K1728_11665	COG0765	amino acid transport
K1728_11670	COG1126	abc transporter atp-binding protein
K1728_11675	COG0390	transport system, permease component
K1728_11680	COG4619	ABC transporter
K1728_11690	COG0656	L-ascorbic acid biosynthetic process
K1728_11700	COG1132	(ABC) transporter
K1728_11705	COG1846	Transcriptional regulator
K1728_11725	COG0697	spore germination
K1728_11735	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
K1728_11740	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
K1728_11755	COG1388	LysM domain
K1728_11775	COG1744	ABC transporter substrate-binding protein PnrA-like
K1728_11805	COG1506	peptidase
K1728_11805	COG0823	Involved in the tonB-independent uptake of proteins
K1728_11805	COG4946	Tricorn protease homolog
K1728_11810	COG1464	Belongs to the NlpA lipoprotein family
K1728_11820	COG1174	glycine betaine transport
K1728_11825	COG0517	IMP dehydrogenase activity
K1728_11825	COG1125	glycine betaine transport
K1728_11840	COG1881	PFAM PEBP family protein
K1728_11860	COG0149	triose-phosphate isomerase activity
K1728_11875	COG1846	Transcriptional regulator
K1728_11880	COG0431	NADPH-dependent FMN reductase
K1728_11885	COG2252	PERMEase
K1728_11910	COG0328	RNA-DNA hybrid ribonuclease activity
K1728_11920	COG0561	phosphatase activity
K1728_11925	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K1728_11930	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
K1728_11975	COG1113	amino acid transport
K1728_11980	COG0569	domain protein
K1728_12000	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
K1728_12005	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K1728_12010	COG1120	ATPase activity
K1728_12025	COG0594	ribonuclease P activity
K1728_12030	COG0230	Belongs to the bacterial ribosomal protein bL34 family
K1728_12035	COG4152	abc transporter atp-binding protein
K1728_12045	COG1668	transmembrane transport
K1728_12070	COG2246	polysaccharide biosynthetic process
K1728_12090	COG2226	methyltransferase
K1728_12110	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K1728_12115	COG4152	abc transporter atp-binding protein
K1728_12120	COG1668	transmembrane transport
K1728_12145	COG2246	polysaccharide biosynthetic process
K1728_12160	COG2226	methyltransferase
K1728_12175	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity