locus-tag	class	description
G4V46_00005	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
G4V46_00010	ENOG4105VG0	50S ribosomal protein l34
G4V46_00015	ENOG4105M7T	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)
G4V46_00025	ENOG4105C3F	Signal peptidase i
G4V46_00030	ENOG4105E0A	ABC, transporter
G4V46_00035	ENOG4105EHG	Permease protein
G4V46_00040	ENOG4108HUF	Transporter
G4V46_00065	ENOG4107ZYR	domain protein
G4V46_00070	ENOG4105C85	amino acid
G4V46_00115	ENOG4108UXA	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity)
G4V46_00125	ENOG4108HCJ	Hydrolase
G4V46_00135	ENOG4108UMW	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
G4V46_00160	ENOG4105C7N	Xanthine uracil vitamin C permease
G4V46_00165	ENOG4108YYH	Nadph-dependent fmn reductase
G4V46_00185	ENOG4105CP7	Triose-phosphate isomerase
G4V46_00225	ENOG4108IJ8	ABC transporter
G4V46_00230	ENOG4105E90	ABC transporter
G4V46_00240	ENOG4105D01	(LipO)protein
G4V46_00245	ENOG4105DRY	peptidase s9 prolyl oligopeptidase active site domain protein
G4V46_00305	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
G4V46_00310	ENOG4105DIH	basic membrane
G4V46_00350	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
G4V46_00355	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
G4V46_00365	ENOG4108UZ3	Transporter
G4V46_00385	ENOG4105FS7	Transcriptional regulator
G4V46_00390	ENOG4105BZ1	(ABC) transporter
G4V46_00410	ENOG41083J0	(ABC) transporter
G4V46_00415	ENOG4105C4B	ABC transporter, permease
G4V46_00420	ENOG4105CDA	abc transporter atp-binding protein
G4V46_00425	ENOG4105E5Q	amino acid AbC transporter
G4V46_00435	ENOG4105EAB	amino acid AbC transporter
G4V46_00440	ENOG410855V	Acylphosphatase
G4V46_00455	ENOG4105DQ6	Transposase
G4V46_00470	ENOG4105DQ6	Transposase
G4V46_00495	ENOG4105KVH	Transcriptional regulator
G4V46_00510	ENOG4105DQ6	Transposase
G4V46_00530	ENOG4105C85	amino acid
G4V46_00565	ENOG4105HMI	Membrane
G4V46_00585	ENOG4105CI2	imidazolone-5-propionate hydrolase
G4V46_00590	ENOG4105CUB	amino acid
G4V46_00600	ENOG4105CSC	Glucose uptake protein
G4V46_00605	ENOG4105EVU	fructokinase
G4V46_00615	ENOG4105CQ3	Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity)
G4V46_00625	ENOG4107U9W	Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S- specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX (By similarity)
G4V46_00635	ENOG4105D8C	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity)
G4V46_00640	ENOG4105CPQ	Dehydrogenase
G4V46_00645	ENOG4108W5N	phosphatidylglycerophosphatase a
G4V46_00650	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
G4V46_00655	ENOG4105CSC	Glucose uptake protein
G4V46_00660	ENOG4107R7I	amino acid
G4V46_00705	ENOG4105CUB	amino acid
G4V46_00710	ENOG4105HDK	L-asparaginase
G4V46_00715	ENOG4105VEM	Conserved domain protein
G4V46_00725	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
G4V46_00735	ENOG4105KA0	thioesterase Superfamily protein
G4V46_00740	ENOG4108IPT	Naphthoate synthase
G4V46_00745	ENOG4105CEY	Amp-dependent synthetase and ligase
G4V46_00755	ENOG4105DU1	integral membrane protein, terc
G4V46_00760	ENOG4108STX	response regulator
G4V46_00765	ENOG4105US7	Histidine kinase
G4V46_00770	ENOG4105EK5	Glycoside hydrolase family 8
G4V46_00785	ENOG41075H3	AraC family transcriptional regulator
G4V46_00795	ENOG4105ECB	domain protein
G4V46_00805	ENOG4105E66	phosphoriboisomerase A
G4V46_00810	ENOG4105CEN	a g-specific adenine glycosylase
G4V46_00815	ENOG4105DU0	nucleoside hydrolase
G4V46_00825	ENOG4107QJE	Chromosome Partitioning Protein
G4V46_00830	ENOG4105FA0	parb-like partition protein
G4V46_00835	ENOG4105VDK	protein, conserved in bacteria
G4V46_00840	ENOG4105C3G	gtp-binding protein
G4V46_00850	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
G4V46_00910	ENOG4105DUX	Transporter
G4V46_00915	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
G4V46_00920	ENOG4105PY6	Phenolic acid decarboxylase
G4V46_00955	ENOG410906U	SprT-like
G4V46_00960	ENOG4107QW4	alcohol dehydrogenase
G4V46_00965	ENOG4105EXC	Acyl-transferase
G4V46_00970	ENOG4107DA6	Transcriptional regulator
G4V46_00980	ENOG4105FDK	ABC transporter
G4V46_00990	ENOG4105C5H	ABC transporter
G4V46_01020	ENOG4107QNK	)-transporter
G4V46_01030	ENOG4105E5Q	amino acid AbC transporter
G4V46_01050	ENOG4107QNK	)-transporter
G4V46_01070	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
G4V46_01095	ENOG4108TZY	GntR Family Transcriptional Regulator
G4V46_01100	ENOG4107QRI	Phosphoketolase
G4V46_01140	ENOG4105C9K	Endothelin-converting enzyme 1
G4V46_01150	ENOG4105C0A	alcohol dehydrogenase
G4V46_01165	ENOG4105CGK	Exodeoxyribonuclease III
G4V46_01170	ENOG4105CJ1	ABC, transporter
G4V46_01190	ENOG4105DKJ	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
G4V46_01195	ENOG4105C1N	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity)
G4V46_01205	ENOG4105BZ1	(ABC) transporter
G4V46_01210	ENOG4105BZ1	(ABC) transporter
G4V46_01225	ENOG4105DQ6	Transposase
G4V46_01240	ENOG4105DQ6	Transposase
G4V46_01265	ENOG4105DG6	mannose-6-phosphate isomerase
G4V46_01280	ENOG4105DMS	mur ligase
G4V46_01285	ENOG4105F1K	Glutamine amidotransferase
G4V46_01305	ENOG4107104	thymidine kinase
G4V46_01315	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
G4V46_01320	ENOG4105EK0	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
G4V46_01325	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
G4V46_01330	ENOG4105CZ5	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity)
G4V46_01335	ENOG4105CGD	Nad-dependent epimerase dehydratase
G4V46_01345	ENOG4107RFS	it plays a direct role in the translocation of protons across the membrane (By similarity)
G4V46_01350	ENOG4105WS6	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
G4V46_01355	ENOG4107ZFM	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity)
G4V46_01360	ENOG4107YZM	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
G4V46_01365	ENOG4105CDG	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity)
G4V46_01370	ENOG4105J80	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity)
G4V46_01375	ENOG4105C4J	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
G4V46_01380	ENOG4105KNM	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
G4V46_01385	ENOG4108VXD	carboxy-peptidase
G4V46_01390	ENOG4105ZMH	deoxynucleoside kinase
G4V46_01395	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
G4V46_01425	ENOG4105KEX	transcriptional regulator, ctsr
G4V46_01430	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
G4V46_01435	ENOG4108IIJ	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
G4V46_01440	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
G4V46_01445	ENOG4107QW4	alcohol dehydrogenase
G4V46_01465	ENOG4105DHI	Methyltransferase
G4V46_01500	ENOG4105DJ2	Major Facilitator Superfamily
G4V46_01505	ENOG4108URH	decarboxylase
G4V46_01510	ENOG4107Y49	methyltransferase
G4V46_01525	ENOG4105C6E	dna polymerase iii
G4V46_01535	ENOG4105F3K	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity)
G4V46_01550	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
G4V46_01555	ENOG4105X0R	protein from nitrogen regulatory protein P-II
G4V46_01575	ENOG4105CMR	udp-glucose 4-epimerase
G4V46_01595	ENOG4105DQ6	Transposase
G4V46_01610	ENOG41072GX	Peptidase M22 Glycoprotease
G4V46_01635	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
G4V46_01640	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
G4V46_01645	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
G4V46_01650	ENOG41080UE	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
G4V46_01655	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
G4V46_01665	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
G4V46_01670	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
G4V46_01680	ENOG41082SA	50s ribosomal protein l29
G4V46_01685	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
G4V46_01690	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
G4V46_01695	ENOG4105KAR	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity)
G4V46_01700	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
G4V46_01705	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
G4V46_01710	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
G4V46_01715	ENOG4105K4C	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity)
G4V46_01720	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
G4V46_01730	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
G4V46_01735	ENOG4105CGG	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity)
G4V46_01745	ENOG4105K9U	however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)
G4V46_01750	ENOG41067V7	50S ribosomal protein L36
G4V46_01755	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
G4V46_01760	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
G4V46_01765	ENOG4105CTF	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
G4V46_01770	ENOG4108ZT0	50S ribosomal protein l17
G4V46_01790	ENOG4108UMI	ABC transporter, permease
G4V46_01795	ENOG4108JEI	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity)
G4V46_01800	ENOG4105D01	(LipO)protein
G4V46_01810	ENOG4105DAP	Nicotinate phosphoribosyltransferase
G4V46_01815	ENOG4107RA1	nh(3)-dependent nad( ) synthetase
G4V46_01820	ENOG4107VC8	ATP cone domain protein
G4V46_01835	ENOG4105C8N	cysteinyl-tRNA synthetase
G4V46_01840	ENOG4105CHR	reductase
G4V46_01855	ENOG4106762	Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity)
G4V46_01860	ENOG4105KEB	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
G4V46_01865	ENOG4105C2N	RNA methyltransferase TrmH family group 3
G4V46_01875	ENOG4107FTN	50S ribosomal protein L33
G4V46_01880	ENOG410683Z	Preprotein translocase SecE subunit
G4V46_01885	ENOG4105E5V	Participates in transcription elongation, termination and antitermination (By similarity)
G4V46_01890	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
G4V46_01895	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
G4V46_01900	ENOG4108VZM	50s ribosomal protein L10
G4V46_01905	ENOG4105KBC	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
G4V46_01915	ENOG4105DIK	(ABC) transporter
G4V46_01920	ENOG4105CC5	ABC transporter
G4V46_01925	ENOG4105DSE	periplasmic solute binding protein
G4V46_01940	ENOG4108JJB	ABC transporter
G4V46_01945	ENOG4108JJB	ABC transporter
G4V46_01955	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
G4V46_01960	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
G4V46_01965	ENOG4108UJD	30S ribosomal protein S9
G4V46_01980	ENOG4105F27	Major Facilitator
G4V46_01990	ENOG4105C7K	acetolactate synthase
G4V46_01995	ENOG4108RG0	uracil-dna glycosylase
G4V46_02020	ENOG410841Q	phosphoesterase PA-phosphatase related protein
G4V46_02035	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
G4V46_02050	ENOG4105CHW	UPF0052 protein
G4V46_02055	ENOG4105CIE	May be required for sporulation (By similarity)
G4V46_02075	ENOG4105C5Y	PTS System
G4V46_02080	ENOG41086FC	50S ribosomal protein l32
G4V46_02085	ENOG4105C56	H( )-stimulated, divalent metal cation uptake system (By similarity)
G4V46_02105	ENOG4108TKW	Glyoxalase Bleomycin resistance protein (Dioxygenase
G4V46_02110	ENOG4105DQ6	Transposase
G4V46_02125	ENOG4107QJZ	Glycosyl transferase, family 2
G4V46_02140	ENOG4105C80	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
G4V46_02150	ENOG4107FQX	Alpha-acetolactate decarboxylase
G4V46_02160	ENOG4105K4H	Nlp p60 protein
G4V46_02175	ENOG4107Z0P	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity)
G4V46_02185	ENOG4105CTP	PilT protein domain protein
G4V46_02190	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
G4V46_02195	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
G4V46_02200	ENOG4105CG1	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity)
G4V46_02210	ENOG4105GP2	5'(3')-deoxyribonucleotidase
G4V46_02240	ENOG4108RWN	rrna methyltransferase
G4V46_02270	ENOG4105CSS	phenylalanyl-tRNA synthetase (alpha subunit)
G4V46_02275	ENOG4105C6A	phenylalanyl-tRNA synthetase (beta subunit)
G4V46_02285	ENOG4105C9U	ATP-dependent DNA helicase RecQ
G4V46_02290	ENOG4108UKH	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
G4V46_02300	ENOG4107RF6	penicillin-binding protein
G4V46_02305	ENOG4105MK2	5-formyltetrahydrofolate cyclo-ligase
G4V46_02330	ENOG4108K5P	(LipO)protein
G4V46_02335	ENOG4107YZP	Rhodanese domain protein
G4V46_02355	ENOG4105KV4	Transcriptional regulator
G4V46_02360	ENOG4105C5F	glutamine synthetase
G4V46_02390	ENOG4105K46	50S ribosomal protein l27
G4V46_02425	ENOG4108IMY	Transcriptional regulator
G4V46_02660	ENOG4108IUM	Glycogen debranching enzyme
G4V46_02700	ENOG4105DQ6	Transposase
G4V46_02710	ENOG4105BZ1	(ABC) transporter
G4V46_02715	ENOG4105E4F	Isochorismate synthase
G4V46_02720	ENOG4105C4A	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity)
G4V46_02725	ENOG4107J5P	Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity)
G4V46_02730	ENOG4107WEA	mandelate racemase muconate lactonizing
G4V46_02735	ENOG4105DC7	peptidase M24
G4V46_02755	ENOG4105MMD	transcriptional regulator
G4V46_02760	ENOG4105D4U	had-superfamily hydrolase, subfamily iia
G4V46_02770	ENOG4105D9R	oxidoreductase
G4V46_02775	ENOG4105DU0	nucleoside hydrolase
G4V46_02795	ENOG4105C8U	phosphate abc transporter
G4V46_02800	ENOG4105E2Z	phosphate ABC transporter (Permease
G4V46_02805	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
G4V46_02810	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
G4V46_02815	ENOG4108UTW	Plays a role in the regulation of phosphate uptake
G4V46_02820	ENOG410902V	Modulates RecA activity (By similarity)
G4V46_02835	ENOG4105C8A	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity)
G4V46_02850	ENOG4105D1H	recombination factor protein RarA
G4V46_02880	ENOG4108UT2	hemolysin iii
G4V46_02895	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
G4V46_02900	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
G4V46_02915	ENOG4105C5H	ABC transporter
G4V46_02930	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
G4V46_02935	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
G4V46_02940	ENOG4105C0X	amino acid
G4V46_02955	ENOG4108WJV	had superfamily (subfamily IIIa) phosphatase
G4V46_02960	ENOG4105CQW	ribosome biogenesis GTPase YqeH
G4V46_02970	ENOG4108Z1W	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity)
G4V46_02975	ENOG4108WF2	Metal Dependent Phosphohydrolase
G4V46_02985	ENOG4105DXX	methyltransferase
G4V46_02990	ENOG4105CDE	UPF0348 protein
G4V46_03005	ENOG4105DC6	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity)
G4V46_03030	ENOG4105C22	threonyL-tRNA synthetase
G4V46_03035	ENOG4105CKA	Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity)
G4V46_03050	ENOG4107WD8	ABC transporter, permease
G4V46_03070	ENOG4108V7D	UPF0397 protein
G4V46_03075	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
G4V46_03090	ENOG4105CTB	Polyprenyl synthetase
G4V46_03095	ENOG4105DX0	Hemolysin A
G4V46_03100	ENOG4105XBY	Regulates arginine biosynthesis genes (By similarity)
G4V46_03105	ENOG4105C4F	May be involved in recombinational repair of damaged DNA (By similarity)
G4V46_03115	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
G4V46_03120	ENOG4105ZAD	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity)
G4V46_03125	ENOG4105DQR	SNARE associated Golgi
G4V46_03245	ENOG4105C5I	Dehydrogenase
G4V46_03255	ENOG4105C4M	(Ubiquinol oxidase) subunit I
G4V46_03260	ENOG4105CFY	cytochrome d ubiquinol oxidase, subunit ii
G4V46_03265	ENOG4108JJ9	ABC, transporter
G4V46_03270	ENOG4108JJ8	(ABC) transporter
G4V46_03275	ENOG4108ZW7	flagellar rod assembly protein muramidase flgj
G4V46_03280	ENOG4105CY8	phosphoribosylaminoimidazole carboxylase atpase subunit
G4V46_03320	ENOG4105VEQ	Cold shock protein
G4V46_03325	ENOG4108YZ4	nudix hydrolase
G4V46_03335	ENOG4105DUF	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity)
G4V46_03345	ENOG4105FBA	Phospholipase Carboxylesterase
G4V46_03375	ENOG4105WAZ	(Glutaredoxin-like protein) NrdH
G4V46_03380	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
G4V46_03395	ENOG4105C7J	ABC transporter, permease
G4V46_03400	ENOG4108JJB	ABC transporter
G4V46_03405	ENOG4105CMQ	Chloride channel
G4V46_03410	ENOG41087RV	Protein CrcB homolog
G4V46_03415	ENOG4106A8V	Protein CrcB homolog
G4V46_03420	ENOG4105EPR	degv family
G4V46_03425	ENOG4105CI1	PTS System
G4V46_03440	ENOG4105W5Q	DNA repair protein (RadC
G4V46_03445	ENOG4105DFF	Rod shape-determining protein mreb
G4V46_03465	ENOG4105E5Q	amino acid AbC transporter
G4V46_03470	ENOG4105CDA	abc transporter atp-binding protein
G4V46_03475	ENOG4105EAB	amino acid AbC transporter
G4V46_03485	ENOG4108UM6	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity)
G4V46_03490	ENOG4105CY8	phosphoribosylaminoimidazole carboxylase atpase subunit
G4V46_03510	ENOG4108JIU	phosphoribosylformylglycinamidine synthase ii
G4V46_03525	ENOG4108V3E	phosphoribosylglycinamide formyltransferase
G4V46_03530	ENOG4105DC1	bifunctional purine biosynthesis protein purh
G4V46_03535	ENOG4105C12	Phosphoribosylglycinamide synthetase
G4V46_03540	ENOG4105CKU	formyltetrahydrofolate synthetase
G4V46_03555	ENOG4108IQI	permease
G4V46_03560	ENOG4105CA9	Pyruvate kinase
G4V46_03565	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
G4V46_03570	ENOG4107TVK	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity)
G4V46_03580	ENOG4108V6E	Cell division protein mraZ
G4V46_03595	ENOG4105CJN	penicillin-binding protein
G4V46_03600	ENOG4105CPY	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity)
G4V46_03605	ENOG4105DMZ	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity)
G4V46_03610	ENOG4105DVQ	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity)
G4V46_03615	ENOG4108W8M	Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity)
G4V46_03620	ENOG4105CIT	This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity)
G4V46_03625	ENOG4105CDK	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity)
G4V46_03630	ENOG4105VR5	Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity)
G4V46_03655	ENOG4107TB6	phosphoglycerate mutase
G4V46_03665	ENOG4105C7H	Helicase, RecD TraA family
G4V46_03670	ENOG4105CDY	transcriptional regulatory protein
G4V46_03675	ENOG4105C7N	Xanthine uracil vitamin C permease
G4V46_03725	ENOG4105C6H	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity)
G4V46_03750	ENOG4105C25	Primosomal protein n'
G4V46_03755	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
G4V46_03760	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
G4V46_03770	ENOG4105D9P	serine threonine protein kinase
G4V46_03775	ENOG4105E06	May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity)
G4V46_03780	ENOG4105DJV	ribulose-phosphate 3-epimerase
G4V46_03785	ENOG4105FJ0	thiamine
G4V46_03790	ENOG4105VB9	50S ribosomal protein l28
G4V46_03800	ENOG4105DP4	dak2 domain fusion protein ylov
G4V46_03825	ENOG4105CB5	ATP-dependent DNA helicase recG
G4V46_03830	ENOG4105C6B	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity)
G4V46_03835	ENOG4105VNB	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
G4V46_03840	ENOG4108ZBM	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity)
G4V46_03845	ENOG4105CDB	Required for chromosome condensation and partitioning (By similarity)
G4V46_03850	ENOG4105CCP	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
G4V46_03860	ENOG4105CB9	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
G4V46_03875	ENOG4105K5M	30s ribosomal protein S16
G4V46_03885	ENOG4105DKJ	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
G4V46_03890	ENOG4107Z8R	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity)
G4V46_03895	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
G4V46_03900	ENOG4108YY1	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity)
G4V46_03910	ENOG4107AYK	membrAne
G4V46_03915	ENOG41069HH	4-oxalocrotonate tautomerase
G4V46_03930	ENOG4105ZMH	deoxynucleoside kinase
G4V46_03935	ENOG4105M2E	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity)
G4V46_03940	ENOG410667J	hydrolase
G4V46_03975	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
G4V46_04055	ENOG4108PNI	recT protein
G4V46_04200	ENOG41068JE	domain protein
G4V46_04295	ENOG4108C33	Resolvase
G4V46_04325	ENOG4108VY7	phosphate-starvation-inducible protein PsiE
G4V46_04335	ENOG4105CDW	Resistance protein
G4V46_04340	ENOG41090SU	Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity)
G4V46_04355	ENOG4105DQ6	Transposase
G4V46_04385	ENOG4105DPN	Oligoendopeptidase f
G4V46_04390	ENOG4105D8C	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity)
G4V46_04405	ENOG4105ETE	Transcriptional regulator (LacI family
G4V46_04410	ENOG4105DC7	peptidase M24
G4V46_04490	ENOG4105CJS	Phosphopantothenoylcysteine decarboxylase
G4V46_04495	ENOG4105F99	Hydroxymethylglutaryl-CoA synthase
G4V46_04510	ENOG4105C5C	n-acetylmuramoyl-l-alanine amidase
G4V46_04520	ENOG4105CUT	histidyl-tRNA synthetase
G4V46_04525	ENOG4105C9M	aspartyl-trna synthetase
G4V46_04535	ENOG4107AYK	membrAne
G4V46_04540	ENOG4105VCC	30S ribosomal protein S21
G4V46_04545	ENOG4105KTH	gatB Yqey
G4V46_04550	ENOG4105C9A	Phoh family
G4V46_04555	ENOG4105KGE	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity)
G4V46_04565	ENOG4105CWT	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity)
G4V46_04580	ENOG4108HMW	glycyl-tRNA synthetase, alpha subunit
G4V46_04585	ENOG4105C38	Glycyl-tRNA synthetase beta subunit
G4V46_04595	ENOG4105DU1	integral membrane protein, terc
G4V46_04605	ENOG4105HHQ	6-phosphogluconolactonase (EC 3.1.1.31)
G4V46_04615	ENOG4108UIQ	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity)
G4V46_04620	ENOG4105CNU	cell division protein FtsK
G4V46_04630	ENOG4108IUX	(ABC) transporter
G4V46_04635	ENOG4105RHA	ABC transporter, permease
G4V46_04645	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
G4V46_04650	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
G4V46_04655	ENOG4108ZK7	protein family UPF0029, Impact, N-terminal protein
G4V46_04665	ENOG4105C6X	Major Facilitator
G4V46_04670	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
G4V46_04675	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
G4V46_04680	ENOG4105CPN	adenine deaminase
G4V46_04685	ENOG4105KA4	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity)
G4V46_04690	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
G4V46_04695	ENOG4105E2N	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity)
G4V46_04730	ENOG4105C6U	Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity)
G4V46_04735	ENOG4105VIE	preprotein translocase, subunit YajC
G4V46_04740	ENOG4105CQ3	Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity)
G4V46_04745	ENOG4105SFS	phosphoesterase RecJ domain protein
G4V46_04750	ENOG4105C1J	atp-dependent rna helicase
G4V46_04765	ENOG4105BZW	Glycerate kinase
G4V46_04770	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
G4V46_04775	ENOG4105VBH	UPF0297 protein
G4V46_04780	ENOG4108Z08	Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity)
G4V46_04785	ENOG4105VPH	UPF0473 protein
G4V46_04790	ENOG4105VPH	UPF0473 protein
G4V46_04795	ENOG4105KQC	Competence protein
G4V46_04800	ENOG4108EQH	DNA internalization-related competence protein ComEC Rec2
G4V46_04805	ENOG4105TQK	DNA polymerase iii, delta' subunit
G4V46_04810	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
G4V46_04815	ENOG4105KQV	Binds directly to 16S ribosomal RNA (By similarity)
G4V46_04835	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
G4V46_04850	ENOG4105DEA	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation
G4V46_04855	ENOG4105CHN	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
G4V46_04860	ENOG4105WHM	Necessary for normal cell division and for the maintenance of normal septation (By similarity)
G4V46_04885	ENOG4105C98	muts2 protein
G4V46_04910	ENOG4105EAG	UDP-N-acetylglucosamine 2-epimerase
G4V46_04925	ENOG4105K63	Thioredoxin
G4V46_04930	ENOG4108UW5	maltose o-acetyltransferase
G4V46_04935	ENOG4107RNS	bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic
G4V46_04940	ENOG4108IJ9	(ABC) transporter
G4V46_04945	ENOG4105DB9	Binding-protein-dependent transport systems inner membrane component
G4V46_04950	ENOG4105F66	Binding-protein-dependent transport systems inner membrane component
G4V46_04980	ENOG4105DQ6	Transposase
G4V46_04995	ENOG4105CD8	aminopeptidase N
G4V46_05030	ENOG4105C7H	Helicase, RecD TraA family
G4V46_05035	ENOG4105CH6	catalase
G4V46_05050	ENOG4105C3F	Signal peptidase i
G4V46_05065	ENOG4105C5Y	PTS System
G4V46_05110	ENOG4108M15	ABC transporter
G4V46_05125	ENOG4108V7D	UPF0397 protein
G4V46_05130	ENOG4108JJB	ABC transporter
G4V46_05145	ENOG4105DQ6	Transposase
G4V46_05200	ENOG4105CS2	ec 3.2.1.21
G4V46_05225	ENOG4105C4U	4-methyl-5-beta-hydroxyethylthiazole kinase
G4V46_05230	ENOG4105DWF	phosphomethylpyrimidine kinase
G4V46_05235	ENOG4108UV6	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity)
G4V46_05310	ENOG4107XGZ	Hydrolase
G4V46_05315	ENOG4105F03	Provides the (R)-glutamate required for cell wall biosynthesis (By similarity)
G4V46_05320	ENOG4108V82	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
G4V46_05340	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
G4V46_05345	ENOG4105EMS	pseudouridine synthase
G4V46_05350	ENOG4105CJW	magnesium transporter
G4V46_05355	ENOG4105C2C	drug resistance transporter, Bcr CflA
G4V46_05360	ENOG4108M15	ABC transporter
G4V46_05385	ENOG4105MRB	Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity)
G4V46_05390	ENOG4105EDR	glucose galactose transporter
G4V46_05430	ENOG4105UNS	Pfam:DUF419
G4V46_05455	ENOG4107QMW	pyridine nucleotide-disulfide oxidoreductase
G4V46_05480	ENOG4105CV8	reductase
G4V46_05485	ENOG4108UWZ	4-Carboxymuconolactone decarboxylase
G4V46_05500	ENOG4108U05	Transcriptional regulator
G4V46_05505	ENOG41090PH	Protease synthase and sporulation negative regulatory protein pai 1
G4V46_05515	ENOG4105MKU	Transcriptional regulator
G4V46_05560	ENOG4105CMY	5-enolpyruvylshikimate-3-phosphate synthase
G4V46_05570	ENOG4105KHV	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity)
G4V46_05575	ENOG4105EMV	Major Facilitator
G4V46_05580	ENOG4105D10	5-enolpyruvylshikimate-3-phosphate phospholyase
G4V46_05585	ENOG4105CXG	d-lactate dehydrogenase
G4V46_05600	ENOG4105CZM	Major Facilitator
G4V46_05620	ENOG4105CHV	Transcription elongation factor NusA
G4V46_05625	ENOG4105VZN	Nucleic-acid-binding protein implicated in transcription termination
G4V46_05635	ENOG4107QHU	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
G4V46_05640	ENOG4105KG7	Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity)
G4V46_05645	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
G4V46_05665	ENOG4105DTN	riboflavin biosynthesis protein ribF
G4V46_05675	ENOG4106N3A	copper homeostasis protein cutc
G4V46_05690	ENOG4105DEU	major facilitator superfamily
G4V46_05695	ENOG4105EPR	degv family
G4V46_05700	ENOG4108RCR	degv family
G4V46_05705	ENOG41090WU	lipolytic protein G-D-S-L family
G4V46_05715	ENOG4105VSD	UPF0346 protein
G4V46_05720	ENOG4105C9W	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity)
G4V46_05725	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
G4V46_05735	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
G4V46_05740	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
G4V46_05750	ENOG4105K7Z	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity)
G4V46_05755	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
G4V46_05775	ENOG4108IJ7	Glycine betaine
G4V46_05785	ENOG4107QMW	pyridine nucleotide-disulfide oxidoreductase
G4V46_05790	ENOG4105D01	(LipO)protein
G4V46_05795	ENOG4108HW8	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity)
G4V46_05845	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
G4V46_05850	ENOG4105WBI	UPF0223 protein
G4V46_05855	ENOG4105ECY	inositol monophosphatase
G4V46_05860	ENOG4105CI3	gtp-binding protein typa
G4V46_05865	ENOG4105CNI	cell division protein FtsW
G4V46_05870	ENOG4105WUC	UPF0298 protein
G4V46_05875	ENOG4106H78	methyltransferase
G4V46_05880	ENOG4108ZEF	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)
G4V46_05885	ENOG41063PX	domain protein
G4V46_05890	ENOG4108UGX	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity)
G4V46_05895	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
G4V46_05900	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
G4V46_05905	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
G4V46_05930	ENOG4105DPZ	Two component transcriptional regulator (Winged helix family
G4V46_05935	ENOG4105BZU	Histidine kinase
G4V46_05940	ENOG4105DBI	uridine monophosphokinase
G4V46_05945	ENOG4105CN9	Peptidase m42 family protein
G4V46_05950	ENOG4108VDD	TRNA binding domain protein
G4V46_05960	ENOG4105DFU	Cell wall formation (By similarity)
G4V46_05965	ENOG4105HFZ	Membrane
G4V46_05970	ENOG4105C2M	dna polymerase I
G4V46_05975	ENOG4105ERD	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity)
G4V46_06005	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
G4V46_06010	ENOG4105GR3	Histidine kinase
G4V46_06025	ENOG4107SC7	Inner membrane transporter yjeM
G4V46_06030	ENOG41090U3	tautomerase
G4V46_06045	ENOG4107XQC	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins (By similarity)
G4V46_06050	ENOG4105H9W	Short-chain dehydrogenase reductase Sdr
G4V46_06055	ENOG4108JYZ	YitT family
G4V46_06080	ENOG4105I2S	Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity)
G4V46_06085	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
G4V46_06095	ENOG41080TC	multidrug resistance protein
G4V46_06105	ENOG4105DC8	reductase
G4V46_06120	ENOG4105C6K	Malic enzyme
G4V46_06125	ENOG4107ZGM	malolactic fermentation system
G4V46_06130	ENOG4105EMU	Dehydrogenase
G4V46_06135	ENOG4107QTZ	amino acid
G4V46_06145	ENOG410807C	QueT transporter
G4V46_06150	ENOG4105I7Z	Short-chain dehydrogenase reductase Sdr
G4V46_06165	ENOG4106KNP	GTP-binding protein LepA C-terminus
G4V46_06175	ENOG4107R7I	amino acid
G4V46_06205	ENOG4108MK9	spermidine N(1)-acetyltransferase
G4V46_06210	ENOG4105DC8	reductase
G4V46_06215	ENOG4105CFX	Catalyzes the ferrous insertion into protoporphyrin IX (By similarity)
G4V46_06220	ENOG4107QT5	Catalyzes the ferrous insertion into protoporphyrin IX (By similarity)
G4V46_06225	ENOG4107TTW	Catalyzes the ferrous insertion into protoporphyrin IX (By similarity)
G4V46_06230	ENOG4105C56	H( )-stimulated, divalent metal cation uptake system (By similarity)
G4V46_06260	ENOG4105DQ6	Transposase
G4V46_06370	ENOG4105CZ1	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity)
G4V46_06385	ENOG4105K59	histidine triad (HIT) protein
G4V46_06395	ENOG4107VKM	6-phosphogluconolactonase
G4V46_06400	ENOG4105DUX	Transporter
G4V46_06420	ENOG4105D9U	N-acetyltransferase
G4V46_06435	ENOG4107QM9	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity)
G4V46_06440	ENOG4107QTG	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity)
G4V46_06445	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
G4V46_06455	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
G4V46_06470	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
G4V46_06475	ENOG4105C4R	Atp-dependent dna helicase
G4V46_06480	ENOG4105C4H	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity)
G4V46_06490	ENOG4105XWG	Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation (By similarity)
G4V46_06495	ENOG4108UKS	UPF0398 protein
G4V46_06500	ENOG4108UI2	Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity)
G4V46_06505	ENOG4105BZ4	penicillin-binding protein
G4V46_06510	ENOG4105BZ1	(ABC) transporter
G4V46_06515	ENOG4105BZ1	(ABC) transporter
G4V46_06520	ENOG4105HJK	ABC transporter
G4V46_06525	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
G4V46_06530	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
G4V46_06535	ENOG4108JQ7	(ABC) transporter
G4V46_06540	ENOG4105C3U	ABC transporter
G4V46_06645	ENOG4105DQ6	Transposase
G4V46_06785	ENOG4108IMY	Transcriptional regulator
G4V46_06810	ENOG4105VTR	Integrase
G4V46_06815	ENOG4105C5S	asparaginyl-tRNA synthetase
G4V46_06825	ENOG4105DVT	helicase
G4V46_06845	ENOG4106UJV	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity)
G4V46_06860	ENOG41067QW	Transcriptional regulator
G4V46_06865	ENOG4105IKJ	beta-galactosidase small subunit
G4V46_06875	ENOG4105CKN	UDP-glucose-hexose-1-phosphate uridylyltransferase
G4V46_06880	ENOG4105CRD	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity)
G4V46_06885	ENOG4107RBJ	symporter
G4V46_06890	ENOG4107S4Z	Activates expression of the rhaBAD and rhaT operons (By similarity)
G4V46_06900	ENOG41082QR	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
G4V46_06920	ENOG4105DQ6	Transposase
G4V46_06955	ENOG4108JIJ	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity)
G4V46_06970	ENOG4105D42	Cleaves the N-terminal amino acid of tripeptides (By similarity)
G4V46_06975	ENOG4105EGD	dinuclear metal center protein, YbgI family
G4V46_06985	ENOG4107Y70	Heat shock protein
G4V46_07020	ENOG41068YB	TPR repeat-containing protein
G4V46_07055	ENOG4105EYH	Exonuclease
G4V46_07060	ENOG4107RFY	SbcCD D subunit
G4V46_07070	ENOG4105DJ2	Major Facilitator Superfamily
G4V46_07075	ENOG4105PUK	Membrane
G4V46_07085	ENOG4105K70	DNA-binding protein
G4V46_07090	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
G4V46_07095	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
G4V46_07100	ENOG4105CAT	Cytidine monophosphate kinase
G4V46_07110	ENOG4105C9U	ATP-dependent DNA helicase RecQ
G4V46_07120	ENOG4108SAX	Membrane
G4V46_07135	ENOG4105FE9	pseudouridine synthase
G4V46_07140	ENOG4105K8I	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity)
G4V46_07145	ENOG4108KVX	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity)
G4V46_07160	ENOG4105QNR	S1 RNA binding domain protein
G4V46_07175	ENOG4107RWR	Sodium hydrogen exchanger
G4V46_07185	ENOG4108YYA	Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity)
G4V46_07190	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
G4V46_07195	ENOG4105C0B	DNA polymerase III (alpha subunit)
G4V46_07210	ENOG4105C5H	ABC transporter
G4V46_07215	ENOG4105D4J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
G4V46_07235	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
G4V46_07240	ENOG4105BZU	Histidine kinase
G4V46_07255	ENOG4108RB3	Capsular polysaccharide biosynthesis protein
G4V46_07260	ENOG4108KGH	TRANSCRIPTIONal
G4V46_07270	ENOG4108VCV	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity)
G4V46_07275	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
G4V46_07280	ENOG4105CU7	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity)
G4V46_07295	ENOG4105CE9	30S ribosomal protein S2
G4V46_07300	ENOG4105VC4	domain protein
G4V46_07305	ENOG41060K3	Methyltransferase
G4V46_07310	ENOG4105F6E	Acyl-transferase
G4V46_07320	ENOG4105DQ6	Transposase
G4V46_07330	ENOG4105VXM	UPF0154 protein
G4V46_07335	ENOG4105VPS	UPF0291 protein
G4V46_07340	ENOG4105DS7	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity)
G4V46_07350	ENOG4109003	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity)
G4V46_07355	ENOG4105C2R	Single-stranded-DNA-specific exonuclease (RecJ)
G4V46_07380	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
G4V46_07385	ENOG4105CFG	Acts as a chaperone (By similarity)
G4V46_07390	ENOG4105K90	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
G4V46_07395	ENOG4105CI8	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity)
G4V46_07410	ENOG4105EY8	ABC transporter
G4V46_07420	ENOG4108RJ9	Glycosyl transferase, family 2
G4V46_07425	ENOG4105D5D	udp-galactopyranose mutase
G4V46_07435	ENOG4105CKK	Glycosyl transferase, family 2
G4V46_07440	ENOG4105D3Q	Sugar transferase
G4V46_07445	ENOG4105CA1	Removes the N-terminal methionine from nascent proteins (By similarity)
G4V46_07470	ENOG4105DQ6	Transposase
G4V46_07500	ENOG4107X35	defense response to bacterium
G4V46_07505	ENOG4108FQ0	the rest of the oligosaccharide is released intact. Cleaves the peptidoglycan connecting the daughter cells at the end of the cell division cycle, resulting in the separation of the two newly divided cells. Acts as an autolysin in penicillin-induced lysis
G4V46_07540	ENOG4105C88	aminopeptidase
G4V46_07555	ENOG4108YBP	pseudouridine synthase
G4V46_07560	ENOG4105VEQ	Cold shock protein
G4V46_07570	ENOG4105PGM	cation diffusion facilitator family transporter
G4V46_07580	ENOG4105CS9	pantothenic acid kinase
G4V46_07585	ENOG4105EEM	helicase
G4V46_07600	ENOG4105C68	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)
G4V46_07605	ENOG4105CEV	competence damage-inducible protein
G4V46_07610	ENOG4105BZQ	cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase
G4V46_07645	ENOG4105CMG	Carbohydrate kinase
G4V46_07660	ENOG4107QJZ	Glycosyl transferase, family 2
G4V46_07675	ENOG4107VRP	DNA repair exonuclease
G4V46_07680	ENOG4105WZB	UPF0342 protein
G4V46_07685	ENOG4105BZ4	penicillin-binding protein
G4V46_07690	ENOG4105XBY	Regulates arginine biosynthesis genes (By similarity)
G4V46_07695	ENOG4105CJ3	phosphate transporter
G4V46_07700	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
G4V46_07705	ENOG4108Z86	Glutamine amidotransferase
G4V46_07710	ENOG4105C75	arginyL-tRNA synthetase
G4V46_07720	ENOG4107EEN	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity)
G4V46_07725	ENOG4108V82	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
G4V46_07735	ENOG4105DIK	(ABC) transporter
G4V46_07755	ENOG4105CBD	Diacylglycerol kinase
G4V46_07760	ENOG4105CHT	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
G4V46_07765	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
G4V46_07770	ENOG4105VB5	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
G4V46_07775	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
G4V46_07780	ENOG4108KP7	hydrolase
G4V46_07785	ENOG4105GYP	Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity)
G4V46_07805	ENOG4105C56	H( )-stimulated, divalent metal cation uptake system (By similarity)
G4V46_07810	ENOG4108RTV	Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity)
G4V46_07830	ENOG4105CPC	Aldo Keto reductase
G4V46_07835	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
G4V46_07840	ENOG4107RY0	Catalyzes the conversion of dihydroorotate to orotate (By similarity)
G4V46_07850	ENOG4108JJB	ABC transporter
G4V46_07860	ENOG4105C93	Xylose Isomerase
G4V46_07865	ENOG4105FF2	Type I DHQase
G4V46_07870	ENOG4105KHV	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity)
G4V46_07875	ENOG4105CMY	5-enolpyruvylshikimate-3-phosphate synthase
G4V46_07880	ENOG4105D10	5-enolpyruvylshikimate-3-phosphate phospholyase
G4V46_07885	ENOG4105D49	3-dehydroquinate synthase
G4V46_07890	ENOG4108JPM	phospho-2-dehydro-3-deoxyheptonate aldolase
G4V46_07895	ENOG4105E2X	shikimate dehydrogenase
G4V46_07915	ENOG4105E2K	Glycosyl transferase (Group 1
G4V46_07935	ENOG4107URF	beta-phospho-glucomutase
G4V46_07945	ENOG4108IUK	alpha amylase, catalytic
G4V46_07955	ENOG4105FKQ	transcriptional regulator
G4V46_07960	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
G4V46_07965	ENOG4105C19	ABC transporter
G4V46_07980	ENOG4105CZV	ABC transporter
G4V46_07995	ENOG4105CHM	Aminotransferase
G4V46_08005	ENOG4107T66	Releases the N-terminal proline from various substrates (By similarity)
G4V46_08010	ENOG4108J59	Extracellular solute-binding protein, family 5
G4V46_08020	ENOG4105CM3	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity)
G4V46_08025	ENOG4105CHM	Aminotransferase
G4V46_08030	ENOG4105DUK	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity)
G4V46_08035	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
G4V46_08055	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
G4V46_08060	ENOG4105CFH	Aspartokinase
G4V46_08070	ENOG4105ETE	Transcriptional regulator (LacI family
G4V46_08090	ENOG4107RPQ	ABC transporter
G4V46_08100	ENOG4105DQ6	Transposase
G4V46_08105	ENOG4108Z6X	(sortase) family
G4V46_08110	ENOG4105FF6	Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity)
G4V46_08115	ENOG4105FDU	atp-dependent rna helicase
G4V46_08120	ENOG4105EE0	oxidoreductase
G4V46_08125	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
G4V46_08135	ENOG4108V0P	LemA family
G4V46_08145	ENOG4105KRQ	Addiction module toxin, Txe YoeB family
G4V46_08155	ENOG4105E66	phosphoriboisomerase A
G4V46_08165	ENOG4107QTG	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity)
G4V46_08170	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
G4V46_08175	ENOG4108YXN	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity)
G4V46_08185	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
G4V46_08190	ENOG4105CHR	reductase
G4V46_08195	ENOG4105CJF	Malonyl coA-acyl carrier protein transacylase
G4V46_08200	ENOG4105EA8	2-Nitropropane dioxygenase
G4V46_08205	ENOG410854A	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
G4V46_08210	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
G4V46_08215	ENOG4105NTK	Transcriptional repressor Mpra
G4V46_08220	ENOG4108YXN	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity)
G4V46_08230	ENOG4105C83	adenylosuccinate lyase
G4V46_08235	ENOG4107UUG	Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity)
G4V46_08240	ENOG4105CU6	carbamoyl-phosphate synthetase ammonia chain
G4V46_08245	ENOG4105C1M	carbamoyl-phosphate synthetase glutamine chain
G4V46_08250	ENOG4108UK1	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity)
G4V46_08255	ENOG4105C34	Pseudouridine synthase
G4V46_08265	ENOG4105VND	Ribonuclease
G4V46_08270	ENOG4105DFD	Na H antiporter
G4V46_08305	ENOG4105CTD	carboxy-peptidase
G4V46_08310	ENOG4105C85	amino acid
G4V46_08315	ENOG4105CHR	reductase
G4V46_08325	ENOG4108ZQX	ybak prolyl-trna synthetase
G4V46_08335	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
G4V46_08345	ENOG4105CQX	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity)
G4V46_08350	ENOG4105BZ1	(ABC) transporter
G4V46_08355	ENOG4105BZ1	(ABC) transporter
G4V46_08360	ENOG4105DND	Transcriptional regulator
G4V46_08365	ENOG4108UQV	Membrane
G4V46_08370	ENOG4105BZA	Phosphoglycerate kinase
G4V46_08375	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
G4V46_08410	ENOG4105ZT7	DNA-entry nuclease
G4V46_08430	ENOG4108M4D	D-alanyl-lipoteichoic acid biosynthesis protein DltD
G4V46_08440	ENOG4105CK0	Membrane bOund o-acyl transferase mboat family protein
G4V46_08455	ENOG4105DKJ	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
G4V46_08465	ENOG4105F3R	pts system mannose fructose sorbose family iid
G4V46_08470	ENOG4105ETZ	PTS System
G4V46_08480	ENOG4108IJ0	Aspartate ammonia-lyase
G4V46_08490	ENOG41065RQ	ADP-ribosylation crystallin J1
G4V46_08550	ENOG4105E0M	Sulfatase
G4V46_08565	ENOG4105W2C	Glycosyl transferase
G4V46_08570	ENOG4105BZF	Glycosyl transferase (Group 1
G4V46_08575	ENOG41065E1	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
G4V46_08580	ENOG4106EG9	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity)
G4V46_08585	ENOG4107RY0	Catalyzes the conversion of dihydroorotate to orotate (By similarity)
G4V46_08590	ENOG4105CU6	carbamoyl-phosphate synthetase ammonia chain
G4V46_08595	ENOG4105C1M	carbamoyl-phosphate synthetase glutamine chain
G4V46_08600	ENOG4105CD3	dihydroorotase
G4V46_08605	ENOG4105CXT	aspartate transcarbamylase
G4V46_08630	ENOG4107QJF	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity)
G4V46_08635	ENOG4107U5W	ybbr family
G4V46_08645	ENOG4105EEQ	Na H antiporter
G4V46_08650	ENOG4105D4A	Cell wall formation (By similarity)
G4V46_08655	ENOG4105DE5	Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity)
G4V46_08660	ENOG4108RTV	Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity)
G4V46_08665	ENOG4105K8N	protein family UPF0079, ATPase
G4V46_08670	ENOG4108IJ2	phosphate acetyltransferase
G4V46_08685	ENOG410839T	multidrug resistance protein
G4V46_08690	ENOG41080TC	multidrug resistance protein
G4V46_08695	ENOG4105CDA	abc transporter atp-binding protein
G4V46_08700	ENOG4105E5Q	amino acid AbC transporter
G4V46_08710	ENOG4105C40	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity)
G4V46_08720	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
G4V46_08730	ENOG4105DQ6	Transposase
G4V46_08740	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
G4V46_08755	ENOG4105CP7	Triose-phosphate isomerase
G4V46_08760	ENOG4105BZ3	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity)
G4V46_08765	ENOG4105KRI	phosphocarrier protein (HPr
G4V46_08775	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
G4V46_08780	ENOG4105C3M	thioredoxin reductase
G4V46_08795	ENOG4105C3Y	UTP-glucose-1-phosphate uridylyltransferase
G4V46_08805	ENOG4105D1C	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity)
G4V46_08820	ENOG4107YZX	Universal stress protein
G4V46_08830	ENOG4108R5K	PPIases accelerate the folding of proteins (By similarity)
G4V46_08835	ENOG4108HM4	ABC transporter
G4V46_08840	ENOG4105D38	putrescine abc transporter
G4V46_08850	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
G4V46_08860	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
G4V46_08865	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
G4V46_08870	ENOG4108UKE	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity)
G4V46_08885	ENOG4108YZX	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity)
G4V46_08890	ENOG4105VJV	50s ribosomal protein L35
G4V46_08895	ENOG4108UUX	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity)
G4V46_08900	ENOG4105M7K	Involved in the transcription termination process (By similarity)
G4V46_08905	ENOG4108ZSR	alkaline shock protein
G4V46_08910	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
G4V46_08915	ENOG4107QYV	phosphohexose isomerase
G4V46_08920	ENOG4105ENN	converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity)
G4V46_08930	ENOG4105CSC	Glucose uptake protein
G4V46_08935	ENOG4105BZU	Histidine kinase
G4V46_08940	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
G4V46_08945	ENOG4105C7H	Helicase, RecD TraA family
G4V46_08950	ENOG4105DZC	cytosine deaminase
G4V46_08965	ENOG4105DC8	reductase
G4V46_08980	ENOG4105D64	Mechanosensitive ion channel
G4V46_08985	ENOG4107SJ1	Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity)
G4V46_08990	ENOG4107QMW	pyridine nucleotide-disulfide oxidoreductase
G4V46_09005	ENOG4105CHR	reductase
G4V46_09070	ENOG4108UTT	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity)
G4V46_09075	ENOG4105C66	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity)
G4V46_09080	ENOG4108R6K	riboflavin synthase, subunit alpha
G4V46_09085	ENOG4105D1W	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity)
G4V46_09105	ENOG4105C5I	Dehydrogenase
G4V46_09130	ENOG4105DQ6	Transposase
G4V46_09150	ENOG4105DQ6	Transposase
G4V46_09200	ENOG4108HCJ	Hydrolase
G4V46_09240	ENOG4105C19	ABC transporter
G4V46_09250	ENOG4105CHM	Aminotransferase
G4V46_09255	ENOG4105KA3	membrAne
G4V46_09260	ENOG4105CS2	ec 3.2.1.21
G4V46_09265	ENOG4105C5Y	PTS System
G4V46_09280	ENOG4105D7K	pfkb domain protein
G4V46_09295	ENOG4108M60	Transcriptional regulator
G4V46_09300	ENOG4105E4Y	Endoribonuclease that initiates mRNA decay (By similarity)
G4V46_09340	ENOG4108YYH	Nadph-dependent fmn reductase
G4V46_09355	ENOG4105EYF	MMPL domain protein
G4V46_09385	ENOG4105MS2	ribosomal subunit Interface protein
G4V46_09440	ENOG4105C2N	RNA methyltransferase TrmH family group 3
G4V46_09460	ENOG4105DA5	(ABC) transporter
G4V46_09510	ENOG4105DE5	Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity)
G4V46_09515	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
G4V46_09520	ENOG4105DZP	Membrane-associated zinc metalloprotease
G4V46_09525	ENOG4105KNE	Phosphatidate cytidylyltransferase
G4V46_09530	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
G4V46_09535	ENOG4108HCJ	Hydrolase
G4V46_09615	ENOG4108RCR	degv family
G4V46_09625	ENOG4105EE6	Alcohol dehydrogenase zinc-binding domain protein
G4V46_09640	ENOG4108UGV	hypoxanthine phosphoribosyltransferase
G4V46_09645	ENOG4105C91	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
G4V46_09655	ENOG4105C7N	Xanthine uracil vitamin C permease
G4V46_09660	ENOG4108UV6	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity)
G4V46_09670	ENOG4105DGY	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization (By similarity)
G4V46_09695	ENOG4105DQ6	Transposase
G4V46_09705	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
G4V46_09720	ENOG4105CE4	GlcNAc 6-P deacetylase
G4V46_09725	ENOG4105DYT	3-hydroxyacyl-CoA dehydrogenase
G4V46_09730	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
G4V46_09740	ENOG4108HCJ	Hydrolase
G4V46_09745	ENOG4105K85	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity)
G4V46_09750	ENOG4105DQF	Hydrolase
G4V46_09765	ENOG4105II7	pyrroline-5-carboxylate reductase
G4V46_09780	ENOG4105DFF	Rod shape-determining protein mreb
G4V46_09785	ENOG4107EES	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity)
G4V46_09800	ENOG4105UIB	(ABC) transporter
G4V46_09805	ENOG4108JQ9	ABC transporter
G4V46_09810	ENOG4105DIH	basic membrane
G4V46_09815	ENOG4105DIH	basic membrane
G4V46_09820	ENOG4105DIH	basic membrane
G4V46_09825	ENOG4107QMW	pyridine nucleotide-disulfide oxidoreductase
G4V46_09835	ENOG41080HT	Transcriptional regulator, arsr family
G4V46_09840	ENOG4106F5Q	Membrane
G4V46_09855	ENOG4105K8R	UPF0145 protein
G4V46_09860	ENOG4105DKJ	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
G4V46_09865	ENOG4105CAY	ferredoxin--nadp reductase
G4V46_09885	ENOG4105DIH	basic membrane
G4V46_09890	ENOG4105CTR	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity)
G4V46_09895	ENOG4105WD1	Membrane
G4V46_09930	ENOG410605W	Major Facilitator
G4V46_09935	ENOG4105CDU	Replicative dna helicase
G4V46_09940	ENOG4105K9Q	Binds to the 23S rRNA (By similarity)
G4V46_09950	ENOG4108JQ7	(ABC) transporter
G4V46_09960	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
G4V46_09965	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
G4V46_09970	ENOG4108J59	Extracellular solute-binding protein, family 5
G4V46_09975	ENOG4105DU0	nucleoside hydrolase
G4V46_10005	ENOG4105DQ6	Transposase
G4V46_10025	ENOG4105E66	phosphoriboisomerase A
G4V46_10035	ENOG4105ETE	Transcriptional regulator (LacI family
G4V46_10045	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
G4V46_10055	ENOG4105DRP	amino acid AbC transporter
G4V46_10060	ENOG4105EAD	ABC transporter
G4V46_10065	ENOG4105CT1	(ABC) transporter
G4V46_10070	ENOG4105CDA	abc transporter atp-binding protein
G4V46_10085	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
G4V46_10090	ENOG4105VKD	bioY protein
G4V46_10095	ENOG4105HJX	Biotin- acetyl-CoA-carboxylase ligase
G4V46_10120	ENOG4105CT4	transporter
G4V46_10125	ENOG4105DR1	Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity)
G4V46_10130	ENOG4105D9R	oxidoreductase
G4V46_10145	ENOG4105EEM	helicase
G4V46_10155	ENOG4108YZM	Toxic component of a toxin-antitoxin (TA) module (By similarity)
G4V46_10160	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
G4V46_10165	ENOG4105C1J	atp-dependent rna helicase
G4V46_10170	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
G4V46_10175	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
G4V46_10195	ENOG4108Z1Y	Participates in both the initiation and recycling phases of transcription. In the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling (By similarity)
G4V46_10200	ENOG410667J	hydrolase
G4V46_10205	ENOG4105DCI	Phosphohydrolase
G4V46_10215	ENOG4105C0H	protease
G4V46_10220	ENOG4105Q2H	domain protein
G4V46_10235	ENOG4105BZU	Histidine kinase
G4V46_10240	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
G4V46_10275	ENOG4108UUM	single-stranded DNA-binding protein
G4V46_10280	ENOG4108ZDX	Binds together with S18 to 16S ribosomal RNA (By similarity)
G4V46_10290	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
G4V46_10300	ENOG4105DFT	pur operon repressor
G4V46_10305	ENOG4108Z4K	mutator MutT protein
G4V46_10315	ENOG4108HMR	Key enzyme in the regulation of glycerol uptake and metabolism (By similarity)
G4V46_10320	ENOG410605W	Major Facilitator
G4V46_10330	ENOG4107R2I	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation
G4V46_10335	ENOG4105C5N	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
G4V46_10340	ENOG4107QSE	Dipeptidase
G4V46_10345	ENOG4107R7I	amino acid
G4V46_10350	ENOG4105C7Q	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity)
G4V46_10360	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
G4V46_10365	ENOG4105C28	cystathionine
G4V46_10385	ENOG4105CG5	Glycosyl transferase (Group 1
G4V46_10390	ENOG4105C8T	Leucyl-tRNA synthetase
G4V46_10395	ENOG410841Q	phosphoesterase PA-phosphatase related protein
G4V46_10405	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
G4V46_10425	ENOG4105DIH	basic membrane
G4V46_10470	ENOG4105CVR	type I restriction-modification system
G4V46_10500	ENOG4105DQ6	Transposase
G4V46_10520	ENOG4105CA1	Removes the N-terminal methionine from nascent proteins (By similarity)
G4V46_10530	ENOG4108HW8	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity)
G4V46_10535	ENOG4107RNS	bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic
G4V46_10550	ENOG4105D5T	phosphonate abc transporter
G4V46_10575	ENOG4107104	thymidine kinase
G4V46_10580	ENOG4108KGH	TRANSCRIPTIONal
G4V46_10595	ENOG4108STX	response regulator
G4V46_10615	ENOG4105C56	H( )-stimulated, divalent metal cation uptake system (By similarity)
G4V46_10685	ENOG4105CF3	3-Hydroxyisobutyrate dehydrogenase
G4V46_10700	ENOG4107QM2	Aldo Keto reductase
G4V46_10705	ENOG4108UPS	Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity)
G4V46_10710	ENOG4105C2W	permease
G4V46_10720	ENOG4105DC8	reductase
G4V46_10725	ENOG4108ZGC	gaf domain protein
G4V46_10735	ENOG4107S6X	Glycosyl transferase, family 2
G4V46_10775	ENOG4105D5Q	Arginine ornithine antiporter
G4V46_10780	ENOG4105DBV	ornithine carbamoyltransferase
G4V46_10785	ENOG4105CEU	Arginine dihydrolase
G4V46_10790	ENOG4108RYK	Nad-dependent epimerase dehydratase
G4V46_10815	ENOG4106KNT	transcriptional regulator
G4V46_10830	ENOG4107BMA	Transglycosylase associated protein
G4V46_10895	ENOG4105CRK	lysyL-tRNA synthetase
G4V46_10900	ENOG4105F4C	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity)
G4V46_10910	ENOG4108UGV	hypoxanthine phosphoribosyltransferase
G4V46_10925	ENOG41082I2	s4 domain protein
G4V46_10935	ENOG4108JA2	transcriptioN-repair coupling factor
G4V46_10940	ENOG4108ZPD	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity)
G4V46_10950	ENOG4105C9C	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity)
G4V46_10960	ENOG4105CXW	Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity)
G4V46_10965	ENOG4105CNB	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity)
G4V46_10970	ENOG4105CNB	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity)
G4V46_10975	ENOG4105C9C	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity)
G4V46_10980	ENOG4105ECB	domain protein
G4V46_10985	ENOG4105EJ2	Transcriptional regulator
G4V46_11005	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
G4V46_11015	ENOG4105CMG	Carbohydrate kinase
G4V46_11020	ENOG4105C93	Xylose Isomerase
G4V46_11030	ENOG4105CT4	transporter
G4V46_11035	ENOG4105DSG	hydrolase family 43
G4V46_11040	ENOG4107QNK	)-transporter
G4V46_11060	ENOG4105DWR	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity)
G4V46_11080	ENOG41067S9	phage shock protein C, PspC
G4V46_11090	ENOG4108KGH	TRANSCRIPTIONal
G4V46_11100	ENOG4108UK2	deaminase
G4V46_11105	ENOG4105W42	Veg protein
G4V46_11110	ENOG4105C37	(CBS) domain
G4V46_11115	ENOG4105C37	(CBS) domain
G4V46_11125	ENOG4105HVR	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity)
G4V46_11130	ENOG4105F8V	Hydrolase, tatD family
G4V46_11135	ENOG4105EEQ	Na H antiporter
G4V46_11140	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
G4V46_11170	ENOG4105NDF	NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity)
G4V46_11190	ENOG4105E0M	Sulfatase
G4V46_11195	ENOG4108HPG	-acetyltransferase
G4V46_11205	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
G4V46_11210	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
G4V46_11215	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
G4V46_11220	ENOG410848D	S4 domain protein YaaA
G4V46_11225	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
G4V46_11360	ENOG4108IMY	Transcriptional regulator
G4V46_11385	ENOG4105DQ6	Transposase
G4V46_11390	ENOG4108RG0	uracil-dna glycosylase
G4V46_11440	ENOG4105C59	p-type ATPase
G4V46_11450	ENOG4108RG0	uracil-dna glycosylase
G4V46_11485	ENOG4105HUF	DNA protection during starvation protein
G4V46_11490	ENOG4105IJJ	transcriptional regulator, crp fnr family