locus-tag	class	description
EFA59_00005	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
EFA59_00010	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
EFA59_00015	ENOG410848D	S4 domain protein YaaA
EFA59_00020	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
EFA59_00025	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
EFA59_00035	ENOG4105CHR	reductase
EFA59_00040	ENOG4108JEI	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity)
EFA59_00045	ENOG4108UMI	ABC transporter, permease
EFA59_00060	ENOG4105EYF	MMPL domain protein
EFA59_00075	ENOG4105E0M	Sulfatase
EFA59_00095	ENOG4105NDF	NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity)
EFA59_00135	ENOG4105EEQ	Na H antiporter
EFA59_00140	ENOG4105F8V	Hydrolase, tatD family
EFA59_00145	ENOG4105HVR	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity)
EFA59_00150	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
EFA59_00155	ENOG4105C37	(CBS) domain
EFA59_00160	ENOG4105C37	(CBS) domain
EFA59_00165	ENOG4105W42	Veg protein
EFA59_00170	ENOG4108UK2	deaminase
EFA59_00175	ENOG4105C0V	Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity)
EFA59_00180	ENOG4108KGH	TRANSCRIPTIONal
EFA59_00230	ENOG4107RNS	bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic
EFA59_00275	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
EFA59_00285	ENOG4105E0A	ABC, transporter
EFA59_00305	ENOG410667J	hydrolase
EFA59_00340	ENOG4105ER6	polysaccharide biosynthesis protein
EFA59_00360	ENOG4105ECB	domain protein
EFA59_00365	ENOG4105DU1	integral membrane protein, terc
EFA59_00375	ENOG4108ZPD	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity)
EFA59_00380	ENOG4108JA2	transcriptioN-repair coupling factor
EFA59_00390	ENOG41082I2	s4 domain protein
EFA59_00415	ENOG4105F4C	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity)
EFA59_00420	ENOG4105CRK	lysyL-tRNA synthetase
EFA59_00730	ENOG4105K56	Transcriptional regulator
EFA59_00735	ENOG4107QN2	dihydrolipoyl dehydrogenase
EFA59_00740	ENOG4105CIS	alcohol dehydrogenase
EFA59_00745	ENOG4105KA3	membrAne
EFA59_00755	ENOG4105CUU	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity)
EFA59_00780	ENOG4107ZGM	malolactic fermentation system
EFA59_00785	ENOG4105C6K	Malic enzyme
EFA59_00800	ENOG4107BMA	Transglycosylase associated protein
EFA59_00810	ENOG4106KNT	transcriptional regulator
EFA59_00820	ENOG4108JQ0	Key enzyme in the regulation of glycerol uptake and metabolism (By similarity)
EFA59_00830	ENOG4105CM2	brancheD-chain amino acid aminotransferase
EFA59_00850	ENOG4105DC8	reductase
EFA59_00855	ENOG4108RWP	Major Facilitator Superfamily protein
EFA59_00860	ENOG4105C2W	permease
EFA59_00865	ENOG4108UPS	Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity)
EFA59_00870	ENOG4105CF3	3-Hydroxyisobutyrate dehydrogenase
EFA59_00960	ENOG4105CNT	hydrolase family 2
EFA59_00965	ENOG4108IJ9	(ABC) transporter
EFA59_00970	ENOG4105DYT	3-hydroxyacyl-CoA dehydrogenase
EFA59_00975	ENOG4105C28	cystathionine
EFA59_00980	ENOG4105C1B	dTDP-glucose 4-6-dehydratase
EFA59_00985	ENOG4107RGM	aldo keto reductase
EFA59_00995	ENOG4108Z6X	(sortase) family
EFA59_01005	ENOG4105KVH	Transcriptional regulator
EFA59_01010	ENOG4108Z0Z	intracellular protease Pfpi family
EFA59_01015	ENOG4105CQ4	Transcriptional regulator
EFA59_01025	ENOG4107RBJ	symporter
EFA59_01040	ENOG4105VDH	Dihydroxyacetone kinase
EFA59_01045	ENOG4105CMT	Dihydroxyacetone kinase
EFA59_01050	ENOG4108UTZ	Dihydroxyacetone kinase
EFA59_01055	ENOG4106KNT	transcriptional regulator
EFA59_01060	ENOG4105C5Y	PTS System
EFA59_01065	ENOG4105E15	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
EFA59_01070	ENOG4105C7K	acetolactate synthase
EFA59_01080	ENOG4105D2N	Aldolase
EFA59_01095	ENOG4108TKW	Glyoxalase Bleomycin resistance protein (Dioxygenase
EFA59_01100	ENOG4108V06	Glutathione peroxidase
EFA59_01110	ENOG4108YYH	Nadph-dependent fmn reductase
EFA59_01115	ENOG4105DJ2	Major Facilitator Superfamily
EFA59_01120	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
EFA59_01125	ENOG4105ETE	Transcriptional regulator (LacI family
EFA59_01130	ENOG4105U0F	oligosaccharide H symporter, major facilitator superfamily (MFS)
EFA59_01135	ENOG4108HKT	sucrose-6-phosphate hydrolase
EFA59_01140	ENOG4105EVU	fructokinase
EFA59_01150	ENOG410841Q	phosphoesterase PA-phosphatase related protein
EFA59_01155	ENOG4105C8T	Leucyl-tRNA synthetase
EFA59_01190	ENOG4105C7Q	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity)
EFA59_01195	ENOG4107R7I	amino acid
EFA59_01200	ENOG4107QSE	Dipeptidase
EFA59_01205	ENOG4105C5N	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
EFA59_01210	ENOG4107R2I	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation
EFA59_01215	ENOG410605W	Major Facilitator
EFA59_01220	ENOG4108HMR	Key enzyme in the regulation of glycerol uptake and metabolism (By similarity)
EFA59_01230	ENOG4108Z4K	mutator MutT protein
EFA59_01235	ENOG4105DFT	pur operon repressor
EFA59_01245	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
EFA59_01250	ENOG4105DU0	nucleoside hydrolase
EFA59_01255	ENOG4108ZDX	Binds together with S18 to 16S ribosomal RNA (By similarity)
EFA59_01260	ENOG4108UUM	single-stranded DNA-binding protein
EFA59_01285	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
EFA59_01290	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
EFA59_01300	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
EFA59_01305	ENOG4105BZU	Histidine kinase
EFA59_01320	ENOG4105Q2H	domain protein
EFA59_01325	ENOG4105C0H	protease
EFA59_01335	ENOG4105DCI	Phosphohydrolase
EFA59_01340	ENOG410667J	hydrolase
EFA59_01345	ENOG4108Z1Y	Participates in both the initiation and recycling phases of transcription. In the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling (By similarity)
EFA59_01350	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
EFA59_01355	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
EFA59_01360	ENOG4105C1J	atp-dependent rna helicase
EFA59_01365	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
EFA59_01370	ENOG4108YZM	Toxic component of a toxin-antitoxin (TA) module (By similarity)
EFA59_01375	ENOG4105EEM	helicase
EFA59_01380	ENOG4105C31	Tryptophanyl-tRNA synthetase
EFA59_01390	ENOG4105D9R	oxidoreductase
EFA59_01395	ENOG4105DR1	Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity)
EFA59_01405	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
EFA59_01425	ENOG4105CT1	(ABC) transporter
EFA59_01430	ENOG4105EAD	ABC transporter
EFA59_01435	ENOG4105DRP	amino acid AbC transporter
EFA59_01440	ENOG4108J59	Extracellular solute-binding protein, family 5
EFA59_01445	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
EFA59_01450	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
EFA59_01460	ENOG4108JQ7	(ABC) transporter
EFA59_01470	ENOG4105K9Q	Binds to the 23S rRNA (By similarity)
EFA59_01475	ENOG4105CDU	Replicative dna helicase
EFA59_01480	ENOG410605W	Major Facilitator
EFA59_01485	ENOG4107PP3	Acetylornithine deacetylase
EFA59_01490	ENOG4105WD1	Membrane
EFA59_01495	ENOG4105CTR	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity)
EFA59_01500	ENOG4105DIH	basic membrane
EFA59_01505	ENOG4105CZM	Major Facilitator
EFA59_01515	ENOG4105CAY	ferredoxin--nadp reductase
EFA59_01520	ENOG4105DKJ	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
EFA59_01580	ENOG41082JN	Transcriptional regulator
EFA59_01585	ENOG4105CH6	catalase
EFA59_01595	ENOG4105CQ4	Transcriptional regulator
EFA59_01600	ENOG4107RBJ	symporter
EFA59_01605	ENOG4105DME	alpha-galactosidase
EFA59_01615	ENOG4105CHR	reductase
EFA59_01620	ENOG4105C6Z	Gluconate
EFA59_01625	ENOG4106F5Q	Membrane
EFA59_01630	ENOG4105DIH	basic membrane
EFA59_01635	ENOG4108JQ9	ABC transporter
EFA59_01640	ENOG4105UIB	(ABC) transporter
EFA59_01650	ENOG410667J	hydrolase
EFA59_01655	ENOG4107EES	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity)
EFA59_01660	ENOG4105DFF	Rod shape-determining protein mreb
EFA59_01675	ENOG4105II7	pyrroline-5-carboxylate reductase
EFA59_01690	ENOG4108HCJ	Hydrolase
EFA59_01700	ENOG4105CE4	GlcNAc 6-P deacetylase
EFA59_01705	ENOG4105FDP	GntR family transcriptional regulator
EFA59_01710	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
EFA59_01715	ENOG4105DGY	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization (By similarity)
EFA59_01725	ENOG4105C91	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
EFA59_01730	ENOG4108UGV	hypoxanthine phosphoribosyltransferase
EFA59_01735	ENOG4105PGM	cation diffusion facilitator family transporter
EFA59_01750	ENOG4105WH5	Teichoic acid glycosylation protein
EFA59_01755	ENOG4108HCJ	Hydrolase
EFA59_01760	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
EFA59_01765	ENOG4105KNE	Phosphatidate cytidylyltransferase
EFA59_01770	ENOG4105DZP	Membrane-associated zinc metalloprotease
EFA59_01775	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
EFA59_01780	ENOG4105DE5	Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity)
EFA59_01800	ENOG4105C2N	RNA methyltransferase TrmH family group 3
EFA59_01845	ENOG4105MS2	ribosomal subunit Interface protein
EFA59_01885	ENOG4105C59	p-type ATPase
EFA59_01890	ENOG4105E4Y	Endoribonuclease that initiates mRNA decay (By similarity)
EFA59_01900	ENOG4105C19	ABC transporter
EFA59_01910	ENOG4105EVU	fructokinase
EFA59_01950	ENOG4105VBF	alkaline shock protein
EFA59_01955	ENOG4105C6T	cysteine synthase
EFA59_01960	ENOG4105D7W	serine acetyltransferase
EFA59_01965	ENOG4105EYG	tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity)
EFA59_01970	ENOG4105KA3	membrAne
EFA59_02015	ENOG4107BMA	Transglycosylase associated protein
EFA59_02025	ENOG4105KAV	tspo and mbr like protein
EFA59_02055	ENOG4105D64	Mechanosensitive ion channel
EFA59_02070	ENOG4105DZC	cytosine deaminase
EFA59_02075	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
EFA59_02080	ENOG4105BZU	Histidine kinase
EFA59_02085	ENOG4105ENN	converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity)
EFA59_02090	ENOG4107QYV	phosphohexose isomerase
EFA59_02095	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
EFA59_02100	ENOG4108ZSR	alkaline shock protein
EFA59_02105	ENOG4105M7K	Involved in the transcription termination process (By similarity)
EFA59_02110	ENOG4108UUX	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity)
EFA59_02115	ENOG4105VJV	50s ribosomal protein L35
EFA59_02120	ENOG4108YZX	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity)
EFA59_02130	ENOG4108UKE	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity)
EFA59_02135	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
EFA59_02140	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
EFA59_02145	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
EFA59_02150	ENOG4108EG7	Binding-protein-dependent transport systems, inner membrane component
EFA59_02155	ENOG4105D38	putrescine abc transporter
EFA59_02160	ENOG4107RUE	extracellular solute-binding protein family 1
EFA59_02175	ENOG4107YZX	Universal stress protein
EFA59_02190	ENOG4105D1C	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity)
EFA59_02195	ENOG4105CSF	NADPH-dependent glycerol-3-phosphate dehydrogenase
EFA59_02200	ENOG4105C3Y	UTP-glucose-1-phosphate uridylyltransferase
EFA59_02205	ENOG4105C3M	thioredoxin reductase
EFA59_02210	ENOG4105CVJ	phosphoglycerate mutase
EFA59_02215	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
EFA59_02225	ENOG4105KRI	phosphocarrier protein (HPr
EFA59_02230	ENOG4105BZ3	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity)
EFA59_02235	ENOG4105CG3	alpha amylase, catalytic region
EFA59_02245	ENOG4105D56	permease protein
EFA59_02250	ENOG4105EG2	ABC transporter, permease
EFA59_02255	ENOG4108IJ9	(ABC) transporter
EFA59_02265	ENOG4105CP7	Triose-phosphate isomerase
EFA59_02275	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
EFA59_02285	ENOG4105C40	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity)
EFA59_02290	ENOG4108UH4	Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity)
EFA59_02295	ENOG4105E5Q	amino acid AbC transporter
EFA59_02300	ENOG4105CDA	abc transporter atp-binding protein
EFA59_02315	ENOG4108IJ2	phosphate acetyltransferase
EFA59_02325	ENOG4105K8N	protein family UPF0079, ATPase
EFA59_02330	ENOG4105KEG	ribosomal-protein-alanine acetyltransferase
EFA59_02335	ENOG4105DE5	Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity)
EFA59_02340	ENOG4105D4A	Cell wall formation (By similarity)
EFA59_02345	ENOG4107SUZ	Sodium/hydrogen exchanger family
EFA59_02355	ENOG4107U5W	ybbr family
EFA59_02360	ENOG4107QJF	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity)
EFA59_02370	ENOG4105BZF	Glycosyl transferase (Group 1
EFA59_02375	ENOG4105W2C	Glycosyl transferase
EFA59_02390	ENOG4105E0M	Sulfatase
EFA59_02455	ENOG4105ETZ	PTS System
EFA59_02460	ENOG4105F3R	pts system mannose fructose sorbose family iid
EFA59_02470	ENOG4105DKJ	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
EFA59_02475	ENOG4105ZT7	DNA-entry nuclease
EFA59_02480	ENOG4105VTR	Integrase
EFA59_02575	ENOG4108UUM	single-stranded DNA-binding protein
EFA59_02650	ENOG4108TFU	terminase (Small subunit)
EFA59_02655	ENOG4105IG6	Phage terminase, large subunit
EFA59_02785	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
EFA59_02790	ENOG4105BZA	Phosphoglycerate kinase
EFA59_02805	ENOG4105C4U	4-methyl-5-beta-hydroxyethylthiazole kinase
EFA59_02810	ENOG4108UV6	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity)
EFA59_02815	ENOG4108IJ8	ABC transporter
EFA59_02820	ENOG4105E90	ABC transporter
EFA59_02825	ENOG4105CQX	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity)
EFA59_02835	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
EFA59_02845	ENOG4105DFD	Na H antiporter
EFA59_02850	ENOG4105VND	Ribonuclease
EFA59_02860	ENOG4105C34	Pseudouridine synthase
EFA59_02865	ENOG4108UK1	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity)
EFA59_02870	ENOG4105C1M	carbamoyl-phosphate synthetase glutamine chain
EFA59_02875	ENOG4105CU6	carbamoyl-phosphate synthetase ammonia chain
EFA59_02880	ENOG4107UUG	Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity)
EFA59_02885	ENOG4105C83	adenylosuccinate lyase
EFA59_02935	ENOG41067V2	Esterase lipase
EFA59_02945	ENOG4108YXN	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity)
EFA59_02955	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
EFA59_02960	ENOG410854A	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
EFA59_02965	ENOG4105EA8	2-Nitropropane dioxygenase
EFA59_02970	ENOG4105CJF	Malonyl coA-acyl carrier protein transacylase
EFA59_02975	ENOG4105CHR	reductase
EFA59_02980	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
EFA59_02990	ENOG4108YXN	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity)
EFA59_02995	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
EFA59_03000	ENOG4107QTG	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity)
EFA59_03010	ENOG4105E66	phosphoriboisomerase A
EFA59_03020	ENOG4108V0P	LemA family
EFA59_03030	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
EFA59_03040	ENOG4105EE0	oxidoreductase
EFA59_03045	ENOG4105FDU	atp-dependent rna helicase
EFA59_03050	ENOG4105FF6	Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity)
EFA59_03055	ENOG4107RPQ	ABC transporter
EFA59_03070	ENOG4105ETE	Transcriptional regulator (LacI family
EFA59_03080	ENOG4105CFH	Aspartokinase
EFA59_03085	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
EFA59_03090	ENOG4105CU5	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity)
EFA59_03095	ENOG4105DMJ	Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity)
EFA59_03105	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
EFA59_03110	ENOG4105DUK	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity)
EFA59_03115	ENOG4105CHM	Aminotransferase
EFA59_03120	ENOG4105CM3	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity)
EFA59_03130	ENOG4105CHM	Aminotransferase
EFA59_03150	ENOG4105E2X	shikimate dehydrogenase
EFA59_03155	ENOG4108JPM	phospho-2-dehydro-3-deoxyheptonate aldolase
EFA59_03160	ENOG4105D49	3-dehydroquinate synthase
EFA59_03165	ENOG4105D10	5-enolpyruvylshikimate-3-phosphate phospholyase
EFA59_03170	ENOG4105CMY	5-enolpyruvylshikimate-3-phosphate synthase
EFA59_03175	ENOG4105KHV	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity)
EFA59_03180	ENOG4105FF2	Type I DHQase
EFA59_03195	ENOG4108JJB	ABC transporter
EFA59_03200	ENOG4105NSK	ABC superfamily ATP binding cassette transporter membrane protein
EFA59_03205	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
EFA59_03210	ENOG4105CPC	Aldo Keto reductase
EFA59_03215	ENOG4108W15	Protein of unknown function (DUF1456)
EFA59_03220	ENOG4105C56	H( )-stimulated, divalent metal cation uptake system (By similarity)
EFA59_03240	ENOG4105GYP	Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity)
EFA59_03245	ENOG4105DQF	Hydrolase
EFA59_03250	ENOG4105VB5	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
EFA59_03255	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
EFA59_03260	ENOG4105CHT	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
EFA59_03265	ENOG4105CBD	Diacylglycerol kinase
EFA59_03275	ENOG4107R8N	Glycosyl transferase, family 2
EFA59_03285	ENOG4105EAG	UDP-N-acetylglucosamine 2-epimerase
EFA59_03310	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
EFA59_03315	ENOG4108V82	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
EFA59_03320	ENOG4107EEN	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity)
EFA59_03330	ENOG4105C75	arginyL-tRNA synthetase
EFA59_03335	ENOG4105XBY	Regulates arginine biosynthesis genes (By similarity)
EFA59_03340	ENOG4105BZ4	penicillin-binding protein
EFA59_03345	ENOG4105WZB	UPF0342 protein
EFA59_03350	ENOG4107VRP	DNA repair exonuclease
EFA59_03355	ENOG4106D4I	domain protein
EFA59_03360	ENOG4105EQI	Metal Dependent Phosphohydrolase
EFA59_03365	ENOG4105CMG	Carbohydrate kinase
EFA59_03370	ENOG410905X	membrane-flanked domain protein
EFA59_03390	ENOG4105C6Z	Gluconate
EFA59_03410	ENOG4105BZQ	cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase
EFA59_03415	ENOG4105CEV	competence damage-inducible protein
EFA59_03420	ENOG4105C68	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)
EFA59_03425	ENOG4105EEM	helicase
EFA59_03430	ENOG4105CS9	pantothenic acid kinase
EFA59_03450	ENOG4105VEQ	Cold shock protein
EFA59_03455	ENOG4108YBP	pseudouridine synthase
EFA59_03465	ENOG4105C88	aminopeptidase
EFA59_03475	ENOG4108HW8	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity)
EFA59_03480	ENOG4105E0X	reductase
EFA59_03490	ENOG4108115	UPF0145 protein
EFA59_03495	ENOG4105KPE	licD family
EFA59_03505	ENOG4105EY8	ABC transporter
EFA59_03525	ENOG4107SJB	teichoic acid biosynthesis
EFA59_03530	ENOG4107ZIC	Glycerol-3-phosphate cytidylyltransferase
EFA59_03560	ENOG4107RZX	Teichoic acid biosynthesis protein
EFA59_03580	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
EFA59_03635	ENOG4105CA1	Removes the N-terminal methionine from nascent proteins (By similarity)
EFA59_03640	ENOG4105D3Q	Sugar transferase
EFA59_03660	ENOG4105D5D	udp-galactopyranose mutase
EFA59_03675	ENOG4105CKK	Glycosyl transferase, family 2
EFA59_03680	ENOG4108RJ9	Glycosyl transferase, family 2
EFA59_03705	ENOG4105CI8	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity)
EFA59_03710	ENOG4105K90	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
EFA59_03715	ENOG4105CFG	Acts as a chaperone (By similarity)
EFA59_03720	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
EFA59_03740	ENOG4105C2R	Single-stranded-DNA-specific exonuclease (RecJ)
EFA59_03745	ENOG4109003	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity)
EFA59_03765	ENOG4107UZV	polysaccharide biosynthesis
EFA59_03790	ENOG4108UW5	maltose o-acetyltransferase
EFA59_03795	ENOG4105DS7	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity)
EFA59_03800	ENOG4105VPS	UPF0291 protein
EFA59_03805	ENOG4105VXM	UPF0154 protein
EFA59_03810	ENOG4105F6E	Acyl-transferase
EFA59_03815	ENOG41060K3	Methyltransferase
EFA59_03820	ENOG4105VC4	domain protein
EFA59_03825	ENOG4105CE9	30S ribosomal protein S2
EFA59_03830	ENOG4105CU7	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity)
EFA59_03835	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
EFA59_03845	ENOG4108KGH	TRANSCRIPTIONal
EFA59_03850	ENOG4105BZU	Histidine kinase
EFA59_03855	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
EFA59_03865	ENOG4105D4J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
EFA59_03870	ENOG4105C5H	ABC transporter
EFA59_03885	ENOG4105C0B	DNA polymerase III (alpha subunit)
EFA59_03890	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
EFA59_03895	ENOG4108YYA	Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity)
EFA59_03905	ENOG4107RWR	Sodium hydrogen exchanger
EFA59_03915	ENOG4105QNR	S1 RNA binding domain protein
EFA59_03930	ENOG4108KVX	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity)
EFA59_03935	ENOG4105K8I	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity)
EFA59_03940	ENOG4105FE9	pseudouridine synthase
EFA59_03945	ENOG4108SAX	Membrane
EFA59_03955	ENOG4105C9U	ATP-dependent DNA helicase RecQ
EFA59_03965	ENOG4105CAT	Cytidine monophosphate kinase
EFA59_03970	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
EFA59_03975	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
EFA59_03980	ENOG4105K70	DNA-binding protein
EFA59_03985	ENOG4105DWF	phosphomethylpyrimidine kinase
EFA59_03990	ENOG4105PUK	Membrane
EFA59_03995	ENOG4105DJ2	Major Facilitator Superfamily
EFA59_04000	ENOG4107RH8	nuclease SbcCD subunit D
EFA59_04005	ENOG4105EYH	Exonuclease
EFA59_04020	ENOG41068YB	TPR repeat-containing protein
EFA59_04030	ENOG4105EGD	dinuclear metal center protein, YbgI family
EFA59_04040	ENOG4108JIJ	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity)
EFA59_04055	ENOG41082QR	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
EFA59_04060	ENOG4108NUI	synthase
EFA59_04075	ENOG4106432	Mediates binding to human platelets, possibly through a receptor-ligand interaction. Probably associated with virulence in endovascular infection (By similarity)
EFA59_04090	ENOG4108K2B	transcriptional regulator
EFA59_04095	ENOG4107RBJ	symporter
EFA59_04100	ENOG4105CRD	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity)
EFA59_04105	ENOG4105CKN	UDP-glucose-hexose-1-phosphate uridylyltransferase
EFA59_04110	ENOG4105Y7M	Transcriptional regulator, TetR family
EFA59_04115	ENOG4105DC8	reductase
EFA59_04120	ENOG410807C	QueT transporter
EFA59_04125	ENOG4106KNP	GTP-binding protein LepA C-terminus
EFA59_04135	ENOG4105DME	alpha-galactosidase
EFA59_04155	ENOG4105C5I	Dehydrogenase
EFA59_04160	ENOG4105CXG	d-lactate dehydrogenase
EFA59_04170	ENOG4105EXC	Acyl-transferase
EFA59_04195	ENOG4108K79	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
EFA59_04200	ENOG4105D01	(LipO)protein
EFA59_04210	ENOG4107Y70	Heat shock protein
EFA59_04215	ENOG410667J	hydrolase
EFA59_04235	ENOG4105D1Q	UPF0246 protein
EFA59_04240	ENOG4105CVJ	phosphoglycerate mutase
EFA59_04330	ENOG4105CQ3	Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity)
EFA59_04370	ENOG4105ST3	Transcriptional regulator
EFA59_04375	ENOG4105EYF	MMPL domain protein
EFA59_04400	ENOG4105FBQ	ATPase associated with various cellular activities aaa_5
EFA59_04415	ENOG4105ETE	Transcriptional regulator (LacI family
EFA59_04425	ENOG4105CG3	alpha amylase, catalytic region
EFA59_04435	ENOG4105FCD	Major Facilitator
EFA59_04445	ENOG4105JH5	thiaminase II
EFA59_04450	ENOG4105DWF	phosphomethylpyrimidine kinase
EFA59_04465	ENOG41065RQ	ADP-ribosylation crystallin J1
EFA59_04475	ENOG4105CZ1	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity)
EFA59_04490	ENOG4105K59	histidine triad (HIT) protein
EFA59_04500	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
EFA59_04515	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
EFA59_04520	ENOG4105C4R	Atp-dependent dna helicase
EFA59_04525	ENOG4105C4H	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity)
EFA59_04535	ENOG4105XWG	Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation (By similarity)
EFA59_04540	ENOG4108UKS	UPF0398 protein
EFA59_04545	ENOG4108UI2	Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity)
EFA59_04560	ENOG4105C5S	asparaginyl-tRNA synthetase
EFA59_04570	ENOG4105DVT	helicase
EFA59_04575	ENOG4105CRD	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity)
EFA59_04590	ENOG4106UJV	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity)
EFA59_04595	ENOG41064MX	Tetr family transcriptional regulator
EFA59_04600	ENOG4107XQC	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins (By similarity)
EFA59_04610	ENOG4105GR3	Histidine kinase
EFA59_04615	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
EFA59_04640	ENOG4108ZQD	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity)
EFA59_04645	ENOG4105ERD	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity)
EFA59_04695	ENOG4105KA3	membrAne
EFA59_04700	ENOG4105CIS	alcohol dehydrogenase
EFA59_04765	ENOG4105HFZ	Membrane
EFA59_04770	ENOG4105DFU	Cell wall formation (By similarity)
EFA59_04780	ENOG4108VDD	TRNA binding domain protein
EFA59_04785	ENOG4105CN9	Peptidase m42 family protein
EFA59_04795	ENOG4105BZU	Histidine kinase
EFA59_04800	ENOG4105DPZ	Two component transcriptional regulator (Winged helix family
EFA59_04810	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
EFA59_04815	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
EFA59_04840	ENOG4105C0W	non-ribosomal peptide synthetase
EFA59_04855	ENOG4107QMW	pyridine nucleotide-disulfide oxidoreductase
EFA59_04865	ENOG4108IJ8	ABC transporter
EFA59_04885	ENOG4105NA0	Transcriptional regulator
EFA59_04935	ENOG4105CJ1	ABC, transporter
EFA59_04940	ENOG4105VMP	Transcriptional regulator
EFA59_05035	ENOG4107URF	beta-phospho-glucomutase
EFA59_05040	ENOG4105C71	hydrolase family 65, central catalytic
EFA59_05045	ENOG4105C5Y	PTS System
EFA59_05050	ENOG4105C5Y	PTS System
EFA59_05055	ENOG4107414	GntR family transcriptional regulator
EFA59_05060	ENOG4105ETE	Transcriptional regulator (LacI family
EFA59_05065	ENOG4108HKT	sucrose-6-phosphate hydrolase
EFA59_05070	ENOG4105C5Y	PTS System
EFA59_05080	ENOG4105CA1	Removes the N-terminal methionine from nascent proteins (By similarity)
EFA59_05090	ENOG4105BZU	Histidine kinase
EFA59_05115	ENOG4108J59	Extracellular solute-binding protein, family 5
EFA59_05125	ENOG4107QN2	dihydrolipoyl dehydrogenase
EFA59_05130	ENOG4105C7S	Dehydrogenase
EFA59_05140	ENOG4107RUY	(E1 component), alpha subunit
EFA59_05145	ENOG4105DF9	Lipoate-protein, ligase
EFA59_05150	ENOG41063PX	domain protein
EFA59_05155	ENOG4108ZEF	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)
EFA59_05160	ENOG4106H78	methyltransferase
EFA59_05165	ENOG4105WUC	UPF0298 protein
EFA59_05170	ENOG4105CNI	cell division protein FtsW
EFA59_05175	ENOG4105CI3	gtp-binding protein typa
EFA59_05180	ENOG4105ECY	inositol monophosphatase
EFA59_05190	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
EFA59_05215	ENOG4108HW8	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity)
EFA59_05220	ENOG4105D01	(LipO)protein
EFA59_05225	ENOG4107QMW	pyridine nucleotide-disulfide oxidoreductase
EFA59_05240	ENOG4108IJ7	Glycine betaine
EFA59_05250	ENOG4105E2M	Manganese-dependent inorganic pyrophosphatase
EFA59_05260	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
EFA59_05265	ENOG4105K7Z	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity)
EFA59_05275	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
EFA59_05280	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
EFA59_05285	ENOG4105C79	DNA protecting protein DprA
EFA59_05290	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
EFA59_05295	ENOG4105C9W	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity)
EFA59_05310	ENOG41090WU	lipolytic protein G-D-S-L family
EFA59_05315	ENOG4108RCR	degv family
EFA59_05320	ENOG4105EPR	degv family
EFA59_05330	ENOG4106N3A	copper homeostasis protein cutc
EFA59_05335	ENOG4105F23	Fibronectin-binding protein
EFA59_05340	ENOG4105DTN	riboflavin biosynthesis protein ribF
EFA59_05345	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
EFA59_05350	ENOG4105KG7	Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity)
EFA59_05355	ENOG4107EEM	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
EFA59_05365	ENOG4105VZN	Nucleic-acid-binding protein implicated in transcription termination
EFA59_05370	ENOG4105CHV	Transcription elongation factor NusA
EFA59_05375	ENOG4105K7D	Required for maturation of 30S ribosomal subunits (By similarity)
EFA59_05380	ENOG4105CJW	magnesium transporter
EFA59_05385	ENOG4105EMS	pseudouridine synthase
EFA59_05390	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
EFA59_05410	ENOG4108V82	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
EFA59_05420	ENOG4107XGZ	Hydrolase
EFA59_05470	ENOG4105K63	Thioredoxin
EFA59_05475	ENOG4105C98	muts2 protein
EFA59_05490	ENOG4105WHM	Necessary for normal cell division and for the maintenance of normal septation (By similarity)
EFA59_05495	ENOG4105CHN	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
EFA59_05505	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
EFA59_05520	ENOG4105KQV	Binds directly to 16S ribosomal RNA (By similarity)
EFA59_05525	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
EFA59_05530	ENOG4105TQK	DNA polymerase iii, delta' subunit
EFA59_05535	ENOG4105EGY	DNA internalization-related competence protein ComEC Rec2
EFA59_05545	ENOG4105KQC	Competence protein
EFA59_05555	ENOG4105VPH	UPF0473 protein
EFA59_05560	ENOG4108Z08	Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity)
EFA59_05565	ENOG4105VBH	UPF0297 protein
EFA59_05570	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
EFA59_05575	ENOG4105C1J	atp-dependent rna helicase
EFA59_05580	ENOG4105SFS	phosphoesterase RecJ domain protein
EFA59_05585	ENOG4105CQ3	Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity)
EFA59_05590	ENOG4105VIE	preprotein translocase, subunit YajC
EFA59_05630	ENOG4105E2N	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity)
EFA59_05640	ENOG4105KA4	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity)
EFA59_05655	ENOG4108ZK7	protein family UPF0029, Impact, N-terminal protein
EFA59_05660	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
EFA59_05665	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
EFA59_05670	ENOG4105RHA	ABC transporter, permease
EFA59_05675	ENOG4108IUX	(ABC) transporter
EFA59_05680	ENOG4105CNU	cell division protein FtsK
EFA59_05685	ENOG4108UIQ	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity)
EFA59_05695	ENOG4105HHQ	6-phosphogluconolactonase (EC 3.1.1.31)
EFA59_05700	ENOG4105C38	Glycyl-tRNA synthetase beta subunit
EFA59_05705	ENOG4108HMW	glycyl-tRNA synthetase, alpha subunit
EFA59_05710	ENOG4108SAY	Involved in DNA repair and RecF pathway recombination (By similarity)
EFA59_05715	ENOG4105CWT	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity)
EFA59_05725	ENOG4105KGE	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity)
EFA59_05730	ENOG4105C9A	Phoh family
EFA59_05735	ENOG4105KTH	gatB Yqey
EFA59_05740	ENOG4105VCC	30S ribosomal protein S21
EFA59_05745	ENOG4107AYK	membrAne
EFA59_05750	ENOG4105C9M	aspartyl-trna synthetase
EFA59_05755	ENOG4105CUT	histidyl-tRNA synthetase
EFA59_05760	ENOG4105C5C	n-acetylmuramoyl-l-alanine amidase
EFA59_05770	ENOG4105F99	Hydroxymethylglutaryl-CoA synthase
EFA59_05775	ENOG4105CJS	Phosphopantothenoylcysteine decarboxylase
EFA59_05830	ENOG4105DQ6	Transposase
EFA59_05835	ENOG4105ECI	YeeC-like protein
EFA59_05840	ENOG4105F6A	helicase
EFA59_05845	ENOG4105D85	methylase
EFA59_05870	ENOG4105DQ6	Transposase
EFA59_05965	ENOG4105VTR	Integrase
EFA59_05980	ENOG41082SX	arsR family transcriptional regulator
EFA59_05990	ENOG4105H9W	Short-chain dehydrogenase reductase Sdr
EFA59_06000	ENOG4105E2A	Dehydrogenase
EFA59_06005	ENOG4105VUF	Transcriptional regulator
EFA59_06040	ENOG4105MKU	Transcriptional regulator
EFA59_06045	ENOG4108JPW	Aminotransferase
EFA59_06050	ENOG4105D5Q	Arginine ornithine antiporter
EFA59_06055	ENOG4105ETE	Transcriptional regulator (LacI family
EFA59_06060	ENOG4105DC7	peptidase M24
EFA59_06075	ENOG4105DPN	Oligoendopeptidase f
EFA59_06085	ENOG4108SQ7	Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis
EFA59_06090	ENOG41090SU	Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity)
EFA59_06120	ENOG410667J	hydrolase
EFA59_06125	ENOG4105M2E	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity)
EFA59_06130	ENOG4105ZMH	deoxynucleoside kinase
EFA59_06145	ENOG41069HH	4-oxalocrotonate tautomerase
EFA59_06150	ENOG4107AYK	membrAne
EFA59_06160	ENOG4108YY1	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity)
EFA59_06165	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
EFA59_06180	ENOG4105K5M	30s ribosomal protein S16
EFA59_06185	ENOG4105CB9	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
EFA59_06195	ENOG4105CCP	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
EFA59_06200	ENOG4105CDB	Required for chromosome condensation and partitioning (By similarity)
EFA59_06205	ENOG4108ZBM	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity)
EFA59_06210	ENOG4105VNB	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
EFA59_06215	ENOG4105C6B	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity)
EFA59_06220	ENOG4105CB5	ATP-dependent DNA helicase recG
EFA59_06225	ENOG4105DP4	dak2 domain fusion protein ylov
EFA59_06235	ENOG4105VB9	50S ribosomal protein l28
EFA59_06245	ENOG4105DJV	ribulose-phosphate 3-epimerase
EFA59_06255	ENOG4105D9P	serine threonine protein kinase
EFA59_06260	ENOG4108ZF3	Phosphatase
EFA59_06265	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
EFA59_06270	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
EFA59_06275	ENOG4105C25	Primosomal protein n'
EFA59_06305	ENOG4108VAU	general secretion pathway protein G
EFA59_06320	ENOG4105C7N	Xanthine uracil vitamin C permease
EFA59_06325	ENOG4105CDY	transcriptional regulatory protein
EFA59_06330	ENOG4105C7H	Helicase, RecD TraA family
EFA59_06340	ENOG4107RPC	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
EFA59_06345	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
EFA59_06365	ENOG4105VR5	Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity)
EFA59_06370	ENOG4105CDK	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity)
EFA59_06380	ENOG41087KY	Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity)
EFA59_06385	ENOG4105DVQ	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity)
EFA59_06390	ENOG4105DMZ	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity)
EFA59_06395	ENOG4105CPY	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity)
EFA59_06400	ENOG4105CJN	penicillin-binding protein
EFA59_06410	ENOG4105CGJ	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity)
EFA59_06415	ENOG4108V6E	Cell division protein mraZ
EFA59_06425	ENOG4107TVK	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity)
EFA59_06430	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
EFA59_06435	ENOG4105CA9	Pyruvate kinase
EFA59_06440	ENOG4108IQI	permease
EFA59_06450	ENOG4105CKU	formyltetrahydrofolate synthetase
EFA59_06455	ENOG4105EAB	amino acid AbC transporter
EFA59_06460	ENOG4105CDA	abc transporter atp-binding protein
EFA59_06465	ENOG4105E5Q	amino acid AbC transporter
EFA59_06485	ENOG4105DFF	Rod shape-determining protein mreb
EFA59_06490	ENOG4105W5Q	DNA repair protein (RadC
EFA59_06505	ENOG4106A8V	Protein CrcB homolog
EFA59_06510	ENOG4105WMR	Protein CrcB homolog
EFA59_06520	ENOG4105C7J	ABC transporter, permease
EFA59_06535	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
EFA59_06540	ENOG4105WAZ	(Glutaredoxin-like protein) NrdH
EFA59_06570	ENOG4105DUF	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity)
EFA59_06580	ENOG4108YZ4	nudix hydrolase
EFA59_06585	ENOG4105VEQ	Cold shock protein
EFA59_06605	ENOG4108ZW7	flagellar rod assembly protein muramidase flgj
EFA59_06610	ENOG4108JJ8	(ABC) transporter
EFA59_06615	ENOG4108JJ9	ABC, transporter
EFA59_06620	ENOG4105CFY	cytochrome d ubiquinol oxidase, subunit ii
EFA59_06740	ENOG4105BZM	domain protein
EFA59_06750	ENOG4105DQR	SNARE associated Golgi
EFA59_06755	ENOG4105ZAD	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity)
EFA59_06760	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
EFA59_06765	ENOG4105C4F	May be involved in recombinational repair of damaged DNA (By similarity)
EFA59_06770	ENOG4105XBY	Regulates arginine biosynthesis genes (By similarity)
EFA59_06775	ENOG4105DX0	Hemolysin A
EFA59_06785	ENOG41067QG	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
EFA59_06790	ENOG4105DVS	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
EFA59_06795	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
EFA59_06800	ENOG4108V7D	UPF0397 protein
EFA59_06810	ENOG4105CKA	Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity)
EFA59_06815	ENOG4105C22	threonyL-tRNA synthetase
EFA59_06820	ENOG4105MHQ	Low-potential electron donor to a number of redox enzymes (By similarity)
EFA59_06825	ENOG4105DC6	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity)
EFA59_06840	ENOG4105CDE	UPF0348 protein
EFA59_06855	ENOG4108WF2	Metal Dependent Phosphohydrolase
EFA59_06860	ENOG4108Z1W	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity)
EFA59_06870	ENOG4105CQW	ribosome biogenesis GTPase YqeH
EFA59_06890	ENOG4105C0X	amino acid
EFA59_06895	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
EFA59_06900	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
EFA59_06905	ENOG4105C5H	ABC transporter
EFA59_06910	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
EFA59_06915	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
EFA59_06925	ENOG4108UT2	hemolysin iii
EFA59_06940	ENOG4107YZX	Universal stress protein
EFA59_06950	ENOG4105D1H	recombination factor protein RarA
EFA59_06965	ENOG4105C8A	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity)
EFA59_06970	ENOG4105EVI	UPF0374 protein
EFA59_06975	ENOG410902V	Modulates RecA activity (By similarity)
EFA59_06980	ENOG4108UTW	Plays a role in the regulation of phosphate uptake
EFA59_06985	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
EFA59_06990	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
EFA59_06995	ENOG4105E2Z	phosphate ABC transporter (Permease
EFA59_07000	ENOG4105C8U	phosphate abc transporter
EFA59_07005	ENOG4105CVA	phosphate
EFA59_07015	ENOG4105D4U	had-superfamily hydrolase, subfamily iia
EFA59_07020	ENOG4105MMD	transcriptional regulator
EFA59_07025	ENOG4107R8B	5'-nucleotidase
EFA59_07040	ENOG4105DC7	peptidase M24
EFA59_07045	ENOG4105DTQ	mandelate racemase muconate lactonizing
EFA59_07050	ENOG4107J5P	Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity)
EFA59_07055	ENOG4105C4A	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity)
EFA59_07060	ENOG4105E4F	Isochorismate synthase
EFA59_07065	ENOG4105K46	50S ribosomal protein l27
EFA59_07100	ENOG4105C5F	glutamine synthetase
EFA59_07105	ENOG4105KV4	Transcriptional regulator
EFA59_07115	ENOG4108QXE	glycerophosphoryl diester phosphodiesterase
EFA59_07135	ENOG4105DKQ	ROK family
EFA59_07150	ENOG4105MK2	5-formyltetrahydrofolate cyclo-ligase
EFA59_07155	ENOG4107RF6	penicillin-binding protein
EFA59_07165	ENOG4108UKH	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
EFA59_07170	ENOG4105C9U	ATP-dependent DNA helicase RecQ
EFA59_07180	ENOG4105C6A	phenylalanyl-tRNA synthetase (beta subunit)
EFA59_07185	ENOG4105CSS	phenylalanyl-tRNA synthetase (alpha subunit)
EFA59_07200	ENOG4105CSC	Glucose uptake protein
EFA59_07210	ENOG4108RWN	rrna methyltransferase
EFA59_07220	ENOG4105CG1	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity)
EFA59_07225	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
EFA59_07230	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
EFA59_07235	ENOG4105CTP	PilT protein domain protein
EFA59_07245	ENOG4107Z0P	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity)
EFA59_07255	ENOG4105K4H	Nlp p60 protein
EFA59_07280	ENOG4105CIS	alcohol dehydrogenase
EFA59_07285	ENOG4107FQX	Alpha-acetolactate decarboxylase
EFA59_07320	ENOG4105C5I	Dehydrogenase
EFA59_07325	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
EFA59_07330	ENOG4105CIE	May be required for sporulation (By similarity)
EFA59_07335	ENOG4105CHW	UPF0052 protein
EFA59_07340	ENOG4105C21	Displays ATPase and GTPase activities (By similarity)
EFA59_07350	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
EFA59_07375	ENOG4108RG0	uracil-dna glycosylase
EFA59_07380	ENOG4105CG3	alpha amylase, catalytic region
EFA59_07390	ENOG4105CMG	Carbohydrate kinase
EFA59_07400	ENOG4105DT3	PTS system, galactitol-specific IIc component
EFA59_07425	ENOG4105CPC	Aldo Keto reductase
EFA59_07430	ENOG4105K85	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity)
EFA59_07455	ENOG4105CVA	phosphate
EFA59_07470	ENOG4105EZV	Transcriptional regulator
EFA59_07480	ENOG4105D8C	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity)
EFA59_07485	ENOG4105CP7	Triose-phosphate isomerase
EFA59_07495	ENOG4108HMR	Key enzyme in the regulation of glycerol uptake and metabolism (By similarity)
EFA59_07500	ENOG4105C6F	GntR Family Transcriptional Regulator
EFA59_07505	ENOG4105C6Z	Gluconate
EFA59_07510	ENOG4108UHU	Aldolase
EFA59_07520	ENOG4105CXK	mandelate racemase muconate lactonizing
EFA59_07550	ENOG4107PP3	Acetylornithine deacetylase
EFA59_07575	ENOG4108UJD	30S ribosomal protein S9
EFA59_07580	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
EFA59_07585	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
EFA59_07595	ENOG4108JJB	ABC transporter
EFA59_07600	ENOG4108JJB	ABC transporter
EFA59_07615	ENOG4105DSE	periplasmic solute binding protein
EFA59_07620	ENOG4105CC5	ABC transporter
EFA59_07625	ENOG4105DIK	(ABC) transporter
EFA59_07635	ENOG4105KBC	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
EFA59_07640	ENOG4108VZM	50s ribosomal protein L10
EFA59_07645	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
EFA59_07650	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
EFA59_07655	ENOG4105E5V	Participates in transcription elongation, termination and antitermination (By similarity)
EFA59_07665	ENOG4107FTN	50S ribosomal protein L33
EFA59_07675	ENOG4105C2N	RNA methyltransferase TrmH family group 3
EFA59_07680	ENOG4105KEB	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
EFA59_07685	ENOG41065E1	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
EFA59_07690	ENOG4106EG9	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity)
EFA59_07695	ENOG4107RY0	Catalyzes the conversion of dihydroorotate to orotate (By similarity)
EFA59_07700	ENOG4105CU6	carbamoyl-phosphate synthetase ammonia chain
EFA59_07705	ENOG4105C1M	carbamoyl-phosphate synthetase glutamine chain
EFA59_07710	ENOG4105CD3	dihydroorotase
EFA59_07715	ENOG4105CXT	aspartate transcarbamylase
EFA59_07720	ENOG4105C2X	Arabinose 5-phosphate isomerase
EFA59_07725	ENOG4105CXR	Phospho-2-dehydro-3-deoxyoctonate aldolase
EFA59_07730	ENOG4106762	Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity)
EFA59_07735	ENOG4105C8N	cysteinyl-tRNA synthetase
EFA59_07740	ENOG4105CPC	Aldo Keto reductase
EFA59_07745	ENOG4107RA1	nh(3)-dependent nad( ) synthetase
EFA59_07750	ENOG4105DAP	Nicotinate phosphoribosyltransferase
EFA59_07760	ENOG4105D01	(LipO)protein
EFA59_07765	ENOG4108JEI	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity)
EFA59_07770	ENOG4108UMI	ABC transporter, permease
EFA59_07795	ENOG4105CTF	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
EFA59_07800	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
EFA59_07815	ENOG4105K9U	however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)
EFA59_07820	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
EFA59_07825	ENOG4105CGG	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity)
EFA59_07830	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
EFA59_07835	ENOG4105VPB	50S ribosomal protein L30
EFA59_07840	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
EFA59_07850	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
EFA59_07855	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
EFA59_07860	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
EFA59_07865	ENOG4105KAR	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity)
EFA59_07870	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
EFA59_07875	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
EFA59_07880	ENOG41082SA	50s ribosomal protein l29
EFA59_07885	ENOG4108R70	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity)
EFA59_07890	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
EFA59_07895	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
EFA59_07905	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
EFA59_07910	ENOG41080UE	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
EFA59_07915	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
EFA59_07920	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
EFA59_07925	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
EFA59_07930	ENOG4105EAH	synthase
EFA59_07935	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
EFA59_07950	ENOG41072GX	Peptidase M22 Glycoprotease
EFA59_07955	ENOG4105CMR	udp-glucose 4-epimerase
EFA59_07965	ENOG4105CU0	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity)
EFA59_07975	ENOG4105X0R	protein from nitrogen regulatory protein P-II
EFA59_07980	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
EFA59_07990	ENOG4105F3K	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity)
EFA59_08000	ENOG4105C6E	dna polymerase iii
EFA59_08015	ENOG4107Y49	methyltransferase
EFA59_08025	ENOG4105C5H	ABC transporter
EFA59_08035	ENOG41082BM	Transcriptional regulator, arsr family
EFA59_08045	ENOG4107QNK	)-transporter
EFA59_08050	ENOG41067S9	phage shock protein C, PspC
EFA59_08055	ENOG4107PP3	Acetylornithine deacetylase
EFA59_08075	ENOG4105DHI	Methyltransferase
EFA59_08080	ENOG4107QW4	alcohol dehydrogenase
EFA59_08085	ENOG4107QW4	alcohol dehydrogenase
EFA59_08095	ENOG4108IIJ	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
EFA59_08100	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
EFA59_08105	ENOG4105KEX	transcriptional regulator, ctsr
EFA59_08130	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
EFA59_08135	ENOG4105ZMH	deoxynucleoside kinase
EFA59_08140	ENOG4105KNM	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
EFA59_08145	ENOG4105C4J	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
EFA59_08150	ENOG4105J80	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity)
EFA59_08155	ENOG4105CDG	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity)
EFA59_08160	ENOG4107YZM	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
EFA59_08165	ENOG4107ZFM	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity)
EFA59_08170	ENOG4105WS6	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
EFA59_08190	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
EFA59_08195	ENOG4105EK0	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
EFA59_08200	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
EFA59_08210	ENOG4107104	thymidine kinase
EFA59_08215	ENOG4105F1K	Glutamine amidotransferase
EFA59_08220	ENOG4105DMS	mur ligase
EFA59_08240	ENOG4105CPN	adenine deaminase
EFA59_08245	ENOG4105C7N	Xanthine uracil vitamin C permease
EFA59_08250	ENOG4105EKD	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity)
EFA59_08255	ENOG4107EXU	Short-chain dehydrogenase reductase Sdr
EFA59_08260	ENOG4105BZ1	(ABC) transporter
EFA59_08265	ENOG4105BZ1	(ABC) transporter
EFA59_08275	ENOG4105VZJ	PTS System
EFA59_08280	ENOG4105CK1	PTS System
EFA59_08285	ENOG4105CS2	ec 3.2.1.21
EFA59_08290	ENOG4105VCP	PTS System
EFA59_08295	ENOG4105VZJ	PTS System
EFA59_08300	ENOG4105CS2	ec 3.2.1.21
EFA59_08305	ENOG4108S3Y	transcriptional regulator
EFA59_08310	ENOG4105C1N	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity)
EFA59_08315	ENOG4105DKJ	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
EFA59_08330	ENOG4105CGK	Exodeoxyribonuclease III
EFA59_08335	ENOG4108EKI	Dehydrogenase
EFA59_08340	ENOG4105C59	p-type ATPase
EFA59_08355	ENOG4105NA0	Transcriptional regulator
EFA59_08360	ENOG4105C9K	Endothelin-converting enzyme 1
EFA59_08370	ENOG4107QRI	Phosphoketolase
EFA59_08375	ENOG4108TZY	GntR Family Transcriptional Regulator
EFA59_08395	ENOG4105E5Q	amino acid AbC transporter
EFA59_08420	ENOG4105CAC	Catalyzes the conversion of L-arabinose to L-ribulose (By similarity)
EFA59_08450	ENOG4107QNK	)-transporter
EFA59_08455	ENOG4105C5H	ABC transporter
EFA59_08465	ENOG4105FDK	ABC transporter
EFA59_08480	ENOG4105EXC	Acyl-transferase
EFA59_08500	ENOG4105DUX	Transporter
EFA59_08530	ENOG410841Q	phosphoesterase PA-phosphatase related protein
EFA59_08540	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
EFA59_08550	ENOG4105C3G	gtp-binding protein
EFA59_08560	ENOG4105FA0	parb-like partition protein
EFA59_08565	ENOG4107QJE	Chromosome Partitioning Protein
EFA59_08580	ENOG4105CEN	a g-specific adenine glycosylase
EFA59_08585	ENOG4105E66	phosphoriboisomerase A
EFA59_08590	ENOG4105US7	Histidine kinase
EFA59_08595	ENOG4108STX	response regulator
EFA59_08600	ENOG4107QTZ	amino acid
EFA59_08610	ENOG4105CEY	Amp-dependent synthetase and ligase
EFA59_08615	ENOG4108IPT	Naphthoate synthase
EFA59_08630	ENOG4105VEM	Conserved domain protein
EFA59_08635	ENOG4105HDK	L-asparaginase
EFA59_08655	ENOG4107R7I	amino acid
EFA59_08660	ENOG4105CPQ	Dehydrogenase
EFA59_08665	ENOG4108W5N	phosphatidylglycerophosphatase a
EFA59_08670	ENOG4105D8C	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity)
EFA59_08680	ENOG4107U9W	Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S- specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX (By similarity)
EFA59_08690	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
EFA59_08695	ENOG4108EQA	pts system
EFA59_08705	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
EFA59_08710	ENOG4105F3R	pts system mannose fructose sorbose family iid
EFA59_08725	ENOG4105FDP	GntR family transcriptional regulator
EFA59_08730	ENOG4105FDP	GntR family transcriptional regulator
EFA59_08735	ENOG4105CUB	amino acid
EFA59_08750	ENOG4105HMI	Membrane
EFA59_08755	ENOG4105CEH	Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity)
EFA59_08770	ENOG4105C26	Dehydrogenase
EFA59_08830	ENOG4105C85	amino acid
EFA59_08845	ENOG4105C02	permease
EFA59_08855	ENOG410855V	Acylphosphatase
EFA59_08860	ENOG4105EAB	amino acid AbC transporter
EFA59_08865	ENOG4105E5Q	amino acid AbC transporter
EFA59_08870	ENOG4105CDA	abc transporter atp-binding protein
EFA59_08895	ENOG4105CQB	FAD linked oxidase domain protein
EFA59_08900	ENOG4105EK6	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity)
EFA59_08905	ENOG4108JJB	ABC transporter
EFA59_08910	ENOG4108V7D	UPF0397 protein
EFA59_08915	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
EFA59_08925	ENOG4105DIH	basic membrane
EFA59_08930	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
EFA59_08940	ENOG4105C2S	Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity)
EFA59_08945	ENOG4105CGT	Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity)
EFA59_08950	ENOG4105BZC	d-serine deaminase
EFA59_08965	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
EFA59_08985	ENOG4107TXC	Transcriptional regulator
EFA59_08990	ENOG41079KZ	Major Facilitator Superfamily
EFA59_09015	ENOG4105CXY	transporter
EFA59_09025	ENOG4107QUY	Guanine deaminase
EFA59_09030	ENOG41080Y5	BioY family
EFA59_09045	ENOG4105CMG	Carbohydrate kinase
EFA59_09060	ENOG4107RBJ	symporter
EFA59_09070	ENOG4105C9S	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (By similarity)
EFA59_09075	ENOG4105DU0	nucleoside hydrolase
EFA59_09095	ENOG4105FKQ	transcriptional regulator
EFA59_09100	ENOG4108JZF	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity)
EFA59_09105	ENOG4105KIS	phospholipid-binding protein
EFA59_09110	ENOG4105C5I	Dehydrogenase
EFA59_09115	ENOG4105CHM	Aminotransferase
EFA59_09120	ENOG4108UW5	maltose o-acetyltransferase
EFA59_09125	ENOG4108UW5	maltose o-acetyltransferase
EFA59_09130	ENOG4105F4P	)-transporter
EFA59_09140	ENOG4107QTZ	amino acid
EFA59_09155	ENOG4105CHM	Aminotransferase
EFA59_09165	ENOG4105C7N	Xanthine uracil vitamin C permease
EFA59_09180	ENOG4105CZV	ABC transporter
EFA59_09185	ENOG4107YCY	Transcriptional regulator
EFA59_09190	ENOG4108UMW	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
EFA59_09195	ENOG4108HCJ	Hydrolase
EFA59_09205	ENOG4108UXA	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity)
EFA59_09225	ENOG4105ENX	hydrolase
EFA59_09230	ENOG4105EMU	Dehydrogenase
EFA59_09235	ENOG4105VUF	Transcriptional regulator
EFA59_09240	ENOG4105CK2	sodium dicarboxylate symporter
EFA59_09245	ENOG4105CE7	Amidase, hydantoinase carbamoylase family
EFA59_09250	ENOG4105CA8	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity)
EFA59_09255	ENOG4105D06	uba thif-type nad fad binding protein
EFA59_09275	ENOG4105C85	amino acid
EFA59_09280	ENOG4107ZYR	domain protein
EFA59_09285	ENOG4106ST0	Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity)
EFA59_09300	ENOG4105S6R	Iron-hydroxamate transporter permease subunit
EFA59_09305	ENOG4105E0A	ABC, transporter
EFA59_09315	ENOG4105C3F	Signal peptidase i
EFA59_09320	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
EFA59_09325	ENOG4105M7T	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)
EFA59_09330	ENOG4105VG0	50S ribosomal protein l34
EFA59_09345	ENOG4105C4B	ABC transporter, permease
EFA59_09350	ENOG41083J0	(ABC) transporter
EFA59_09360	ENOG4108UXE	Protein tyrosine phosphatase
EFA59_09365	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
EFA59_09440	ENOG4108C33	Resolvase
EFA59_09460	ENOG4105KVH	Transcriptional regulator
EFA59_09465	ENOG4108VA3	3-hexulose-6-phosphate synthase
EFA59_09475	ENOG4107QYV	phosphohexose isomerase
EFA59_09480	ENOG4107RKG	DJ-1/PfpI family
EFA59_09485	ENOG4105KVH	Transcriptional regulator
EFA59_09505	ENOG4108UXE	Protein tyrosine phosphatase
EFA59_09545	ENOG4105HUF	DNA protection during starvation protein
EFA59_09550	ENOG4105IJJ	transcriptional regulator, crp fnr family
EFA59_09570	ENOG4105DC8	reductase
EFA59_09630	ENOG4105DQ6	Transposase
EFA59_09635	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
EFA59_09670	ENOG4105K63	Thioredoxin