locus-tag	class	description
EFA59_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
EFA59_00010	COG0592	DNA-directed DNA polymerase activity
EFA59_00015	COG2501	S4 domain
EFA59_00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
EFA59_00025	COG0187	DNA topoisomerase II activity
EFA59_00040	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
EFA59_00045	COG2011	ABC-type metal ion transport system permease component
EFA59_00050	COG1464	Belongs to the NlpA lipoprotein family
EFA59_00060	COG2409	Drug exporters of the RND superfamily
EFA59_00075	COG1368	sulfuric ester hydrolase activity
EFA59_00095	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
EFA59_00135	COG0025	NhaP-type Na H and K H
EFA59_00140	COG0084	hydrolase, TatD family'
EFA59_00145	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
EFA59_00150	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
EFA59_00155	COG1253	flavin adenine dinucleotide binding
EFA59_00160	COG1253	flavin adenine dinucleotide binding
EFA59_00165	COG4466	Protein conserved in bacteria
EFA59_00170	COG2131	deaminase
EFA59_00175	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
EFA59_00180	COG1316	TRANSCRIPTIONal
EFA59_00230	COG0737	Belongs to the 5'-nucleotidase family
EFA59_00285	COG1120	ATPase activity
EFA59_00305	COG0561	phosphatase activity
EFA59_00340	COG2244	polysaccharide biosynthetic process
EFA59_00360	COG1511	domain protein
EFA59_00375	COG0193	aminoacyl-tRNA hydrolase activity
EFA59_00380	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
EFA59_00385	COG2244	polysaccharide biosynthetic process
EFA59_00390	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
EFA59_00415	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
EFA59_00420	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
EFA59_00730	COG1846	Transcriptional regulator
EFA59_00735	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EFA59_00740	COG0604	alcohol dehydrogenase
EFA59_00745	COG3759	membrane
EFA59_00755	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
EFA59_00780	COG0583	DNA-binding transcription factor activity
EFA59_00800	COG2261	transglycosylase associated protein
EFA59_00810	COG1737	Transcriptional regulator
EFA59_00815	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
EFA59_00825	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
EFA59_00830	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EFA59_00840	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EFA59_00845	COG1956	GAF domain-containing protein
EFA59_00855	COG2814	Major facilitator Superfamily
EFA59_00860	COG2233	PERMEase
EFA59_00865	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
EFA59_00870	COG2084	Dehydrogenase
EFA59_00875	COG0438	transferase activity, transferring glycosyl groups
EFA59_00945	COG1175	transmembrane transport
EFA59_00960	COG3250	beta-galactosidase activity
EFA59_00965	COG3842	ATPase activity
EFA59_00970	COG1250	3-hydroxyacyl-CoA dehydrogenase
EFA59_00975	COG0626	cystathionine gamma-synthase activity
EFA59_00980	COG1088	dTDP-glucose 4,6-dehydratase activity
EFA59_00985	COG4989	oxidoreductase activity
EFA59_00995	COG3764	Sortase (surface protein transpeptidase)
EFA59_01000	COG0702	epimerase
EFA59_01005	COG1733	regulation of RNA biosynthetic process
EFA59_01010	COG0693	protein deglycase activity
EFA59_01015	COG1609	Transcriptional regulator
EFA59_01020	COG1874	Beta-galactosidase
EFA59_01035	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
EFA59_01040	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
EFA59_01045	COG2376	Dihydroxyacetone kinase
EFA59_01050	COG1461	Dihydroxyacetone kinase
EFA59_01055	COG1737	Transcriptional regulator
EFA59_01060	COG1263	PTS System
EFA59_01060	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EFA59_01065	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
EFA59_01070	COG0028	Belongs to the TPP enzyme family
EFA59_01095	COG2514	catechol 2,3-dioxygenase activity
EFA59_01100	COG0386	Belongs to the glutathione peroxidase family
EFA59_01105	COG1063	alcohol dehydrogenase
EFA59_01110	COG0431	NADPH-dependent FMN reductase
EFA59_01115	COG2807	transmembrane transport
EFA59_01120	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
EFA59_01150	COG0671	phosphoesterase, PA-phosphatase related
EFA59_01155	COG0495	leucyl-tRNA aminoacylation
EFA59_01165	COG2244	polysaccharide biosynthetic process
EFA59_01190	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
EFA59_01195	COG0531	amino acid
EFA59_01200	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EFA59_01205	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
EFA59_01210	COG1074	ATP-dependent DNA helicase activity
EFA59_01215	COG2814	Major facilitator Superfamily
EFA59_01220	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
EFA59_01230	COG1051	belongs to the nudix hydrolase family
EFA59_01235	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
EFA59_01245	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
EFA59_01250	COG1957	nucleoside hydrolase
EFA59_01255	COG0360	Binds together with S18 to 16S ribosomal RNA
EFA59_01260	COG0629	single-stranded DNA binding
EFA59_01265	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
EFA59_01290	COG0516	GMP reductase activity
EFA59_01290	COG0517	IMP dehydrogenase activity
EFA59_01300	COG0745	RESPONSE REGULATOR receiver
EFA59_01305	COG5002	protein histidine kinase activity
EFA59_01320	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
EFA59_01325	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EFA59_01335	COG1078	dGTPase activity
EFA59_01340	COG0561	phosphatase activity
EFA59_01345	COG3343	RNA polymerase activity
EFA59_01350	COG0504	CTP synthase activity
EFA59_01355	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
EFA59_01370	COG2337	Toxic component of a toxin-antitoxin (TA) module
EFA59_01375	COG3973	AAA domain
EFA59_01390	COG0673	inositol 2-dehydrogenase activity
EFA59_01395	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
EFA59_01405	COG0194	GDP metabolic process
EFA59_01425	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EFA59_01430	COG0765	amino acid transport
EFA59_01435	COG0765	amino acid transport
EFA59_01440	COG4166	transmembrane transport
EFA59_01445	COG0601	transmembrane transport
EFA59_01450	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EFA59_01455	COG0444	Belongs to the ABC transporter superfamily
EFA59_01460	COG4608	Belongs to the ABC transporter superfamily
EFA59_01470	COG0359	binds to the 23S rRNA
EFA59_01475	COG0305	Participates in initiation and elongation during chromosome replication
EFA59_01480	COG2814	Major facilitator Superfamily
EFA59_01485	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EFA59_01490	COG2832	Protein of unknown function (DUF454)
EFA59_01500	COG1744	ABC transporter substrate-binding protein PnrA-like
EFA59_01505	COG2814	Major facilitator Superfamily
EFA59_01515	COG0492	ferredoxin-NADP+ reductase activity
EFA59_01520	COG0588	phosphoglycerate mutase activity
EFA59_01580	COG1309	transcriptional regulator
EFA59_01590	COG1064	alcohol dehydrogenase
EFA59_01595	COG1609	Transcriptional regulator
EFA59_01615	COG1028	Short-chain dehydrogenase reductase Sdr
EFA59_01620	COG2610	gluconate transmembrane transporter activity
EFA59_01625	COG0628	permease
EFA59_01630	COG1744	ABC transporter substrate-binding protein PnrA-like
EFA59_01650	COG0561	phosphatase activity
EFA59_01655	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
EFA59_01660	COG1077	Cell shape determining protein MreB Mrl
EFA59_01670	COG0772	Belongs to the SEDS family
EFA59_01675	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
EFA59_01690	COG0561	phosphatase activity
EFA59_01695	COG1136	(ABC) transporter
EFA59_01695	COG0577	efflux transmembrane transporter activity
EFA59_01710	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
EFA59_01715	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
EFA59_01725	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
EFA59_01740	COG0640	Transcriptional regulator
EFA59_01750	COG2246	polysaccharide biosynthetic process
EFA59_01755	COG0561	phosphatase activity
EFA59_01760	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
EFA59_01765	COG4589	Belongs to the CDS family
EFA59_01770	COG0750	zinc metalloprotease
EFA59_01775	COG0442	prolyl-tRNA aminoacylation
EFA59_01780	COG2176	DNA-directed DNA polymerase activity
EFA59_01800	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EFA59_01835	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
EFA59_01845	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
EFA59_01855	COG2183	response to ionizing radiation
EFA59_01885	COG2217	Heavy metal translocating P-type atpase
EFA59_01900	COG1136	(ABC) transporter
EFA59_01910	COG1940	carbohydrate kinase activity
EFA59_01955	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EFA59_01960	COG1045	serine acetyltransferase
EFA59_01965	COG0582	viral genome integration into host DNA
EFA59_01970	COG3759	membrane
EFA59_02015	COG2261	transglycosylase associated protein
EFA59_02025	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
EFA59_02050	COG0516	GMP reductase activity
EFA59_02055	COG0668	transmembrane transport
EFA59_02070	COG0402	S-adenosylhomocysteine deaminase activity
EFA59_02075	COG0745	RESPONSE REGULATOR receiver
EFA59_02080	COG3850	Histidine kinase
EFA59_02080	COG5002	protein histidine kinase activity
EFA59_02085	COG2017	converts alpha-aldose to the beta-anomer
EFA59_02095	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
EFA59_02100	COG1302	Protein conserved in bacteria
EFA59_02110	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
EFA59_02115	COG0291	Belongs to the bacterial ribosomal protein bL35 family
EFA59_02120	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
EFA59_02130	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
EFA59_02135	COG0049	tRNA binding
EFA59_02140	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
EFA59_02145	COG3842	ATPase activity
EFA59_02155	COG1177	transmembrane transport
EFA59_02160	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
EFA59_02175	COG0589	response to stress
EFA59_02190	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
EFA59_02195	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
EFA59_02200	COG1210	Utp--glucose-1-phosphate uridylyltransferase
EFA59_02205	COG0492	ferredoxin-NADP+ reductase activity
EFA59_02210	COG0406	alpha-ribazole phosphatase activity
EFA59_02215	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EFA59_02225	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
EFA59_02245	COG1175	transmembrane transport
EFA59_02250	COG3833	ABC-type maltose transport systems, permease component
EFA59_02255	COG3842	ATPase activity
EFA59_02265	COG0149	triose-phosphate isomerase activity
EFA59_02285	COG0557	exoribonuclease II activity
EFA59_02290	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
EFA59_02295	COG0765	amino acid transport
EFA59_02300	COG1126	abc transporter atp-binding protein
EFA59_02315	COG0280	phosphate acetyltransferase
EFA59_02325	COG0802	atpase or kinase
EFA59_02340	COG0812	UDP-N-acetylmuramate dehydrogenase activity
EFA59_02345	COG0025	NhaP-type Na H and K H
EFA59_02355	COG4856	YbbR-like protein
EFA59_02360	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EFA59_02370	COG0438	transferase activity, transferring glycosyl groups
EFA59_02375	COG0438	transferase activity, transferring glycosyl groups
EFA59_02390	COG1368	sulfuric ester hydrolase activity
EFA59_02455	COG3715	PTS system
EFA59_02460	COG3716	PTS system mannose fructose sorbose family IID component
EFA59_02470	COG0588	phosphoglycerate mutase activity
EFA59_02480	COG0582	viral genome integration into host DNA
EFA59_02550	COG1396	sequence-specific DNA binding
EFA59_02575	COG0629	single-stranded DNA binding
EFA59_02650	COG3728	DNA packaging
EFA59_02650	COG5484	DNA packaging
EFA59_02655	COG1783	phage Terminase large subunit
EFA59_02790	COG0126	phosphoglycerate kinase activity
EFA59_02805	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
EFA59_02815	COG1125	glycine betaine transport
EFA59_02815	COG0517	IMP dehydrogenase activity
EFA59_02820	COG1174	glycine betaine transport
EFA59_02825	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EFA59_02850	COG0328	RNA-DNA hybrid ribonuclease activity
EFA59_02860	COG0564	pseudouridine synthase activity
EFA59_02865	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
EFA59_02870	COG0505	Belongs to the CarA family
EFA59_02880	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EFA59_02885	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
EFA59_02935	COG2267	carboxylic ester hydrolase activity
EFA59_02945	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EFA59_02950	COG1846	Transcriptional regulator
EFA59_02955	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EFA59_02960	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EFA59_02965	COG2070	2-Nitropropane dioxygenase
EFA59_02975	COG1028	Short-chain dehydrogenase reductase Sdr
EFA59_02980	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EFA59_02995	COG0439	Biotin carboxylase
EFA59_03000	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
EFA59_03015	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EFA59_03020	COG1704	LemA family
EFA59_03025	COG0501	Belongs to the peptidase M48B family
EFA59_03030	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
EFA59_03035	COG1335	isochorismatase
EFA59_03040	COG0673	inositol 2-dehydrogenase activity
EFA59_03045	COG0513	Belongs to the DEAD box helicase family
EFA59_03050	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
EFA59_03055	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EFA59_03055	COG1321	iron dependent repressor
EFA59_03080	COG0527	aspartate kinase activity
EFA59_03085	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
EFA59_03090	COG0019	diaminopimelate decarboxylase activity
EFA59_03095	COG2171	N-acyltransferase activity
EFA59_03100	COG1473	amidohydrolase
EFA59_03105	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EFA59_03115	COG0436	Aminotransferase
EFA59_03120	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
EFA59_03130	COG0436	Aminotransferase
EFA59_03135	COG4684	Psort location CytoplasmicMembrane, score
EFA59_03150	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
EFA59_03155	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
EFA59_03160	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
EFA59_03165	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
EFA59_03170	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
EFA59_03175	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
EFA59_03180	COG0710	3-dehydroquinate dehydratase activity
EFA59_03195	COG1122	ATPase activity
EFA59_03200	COG4721	ABC-type cobalt transport system, permease component
EFA59_03205	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
EFA59_03210	COG0667	Aldo Keto reductase
EFA59_03215	COG4807	Protein conserved in bacteria
EFA59_03220	COG1914	H( )-stimulated, divalent metal cation uptake system
EFA59_03240	COG2936	dipeptidyl-peptidase activity
EFA59_03245	COG0561	phosphatase activity
EFA59_03250	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
EFA59_03255	COG0154	amidase activity
EFA59_03260	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
EFA59_03265	COG1597	lipid kinase activity
EFA59_03275	COG1215	transferase activity, transferring glycosyl groups
EFA59_03285	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
EFA59_03310	COG0285	dihydrofolate synthase activity
EFA59_03315	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
EFA59_03330	COG0018	arginyl-trna synthetase
EFA59_03335	COG1438	arginine binding
EFA59_03340	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EFA59_03345	COG3679	Belongs to the UPF0342 family
EFA59_03350	COG0420	3'-5' exonuclease activity
EFA59_03355	COG4717	serine-type aminopeptidase activity
EFA59_03360	COG3481	metal-dependent phosphohydrolase, HD sub domain
EFA59_03365	COG1070	Carbohydrate kinase
EFA59_03370	COG3402	PFAM membrane-flanked domain
EFA59_03390	COG2610	gluconate transmembrane transporter activity
EFA59_03400	COG0612	Peptidase, M16
EFA59_03405	COG1426	Protein conserved in bacteria
EFA59_03410	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
EFA59_03415	COG1546	Belongs to the CinA family
EFA59_03415	COG1058	Belongs to the CinA family
EFA59_03420	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
EFA59_03425	COG3973	AAA domain
EFA59_03435	COG1388	LysM domain
EFA59_03440	COG2814	Major facilitator Superfamily
EFA59_03450	COG1278	Cold shock
EFA59_03455	COG0564	pseudouridine synthase activity
EFA59_03465	COG2309	aminopeptidase activity
EFA59_03480	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EFA59_03490	COG0393	Putative heavy-metal-binding
EFA59_03495	COG3475	LICD family
EFA59_03505	COG1134	teichoic acid transport
EFA59_03505	COG1388	LysM domain
EFA59_03510	COG1682	transport, permease protein
EFA59_03525	COG0463	Glycosyl transferase, family 2
EFA59_03525	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
EFA59_03530	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
EFA59_03560	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
EFA59_03580	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
EFA59_03610	COG1501	Belongs to the glycosyl hydrolase 31 family
EFA59_03635	COG0024	Methionine aminopeptidase
EFA59_03660	COG0562	UDP-galactopyranose mutase
EFA59_03675	COG0463	Glycosyl transferase, family 2
EFA59_03680	COG1216	Glycosyl transferase, family 2
EFA59_03705	COG1420	regulation of RNA biosynthetic process
EFA59_03715	COG0443	Heat shock 70 kDa protein
EFA59_03720	COG0484	heat shock protein binding
EFA59_03735	COG1234	tRNA 3'-trailer cleavage
EFA59_03740	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
EFA59_03740	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
EFA59_03745	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
EFA59_03765	COG1368	sulfuric ester hydrolase activity
EFA59_03790	COG0110	maltose O-acetyltransferase activity
EFA59_03795	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
EFA59_03800	COG4224	UPF0291 protein
EFA59_03805	COG3763	UPF0154 protein
EFA59_03810	COG0204	Acyl-transferase
EFA59_03815	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
EFA59_03820	COG2827	Endonuclease containing a URI domain
EFA59_03825	COG0052	Belongs to the universal ribosomal protein uS2 family
EFA59_03830	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
EFA59_03850	COG0004	ammonium transporteR
EFA59_03855	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
EFA59_03865	COG0617	tRNA 3'-terminal CCA addition
EFA59_03870	COG0488	(ABC) transporter
EFA59_03885	COG0587	DNA-directed DNA polymerase activity
EFA59_03890	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EFA59_03895	COG1490	D-aminoacyl-tRNA deacylase activity
EFA59_03905	COG0475	glutathione-regulated potassium exporter activity
EFA59_03915	COG2996	Protein conserved in bacteria
EFA59_03930	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
EFA59_03935	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
EFA59_03940	COG1187	pseudouridine synthase activity
EFA59_03945	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
EFA59_03955	COG0514	ATP-dependent DNA helicase (RecQ)
EFA59_03965	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
EFA59_03970	COG0539	negative regulation of cytoplasmic translation
EFA59_03975	COG1160	GTP binding
EFA59_03980	COG0776	regulation of translation
EFA59_03985	COG0351	phosphomethylpyrimidine kinase
EFA59_03990	COG4720	Psort location CytoplasmicMembrane, score
EFA59_03995	COG2807	transmembrane transport
EFA59_04000	COG0420	3'-5' exonuclease activity
EFA59_04005	COG0419	ATPase involved in DNA repair
EFA59_04020	COG0457	Tetratricopeptide repeat
EFA59_04025	COG2384	SAM-dependent methyltransferase
EFA59_04030	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
EFA59_04035	COG2195	Cleaves the N-terminal amino acid of tripeptides
EFA59_04040	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
EFA59_04050	COG0267	Belongs to the bacterial ribosomal protein bL33 family
EFA59_04055	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
EFA59_04060	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
EFA59_04090	COG2169	Transcriptional regulator
EFA59_04095	COG2211	Major facilitator Superfamily
EFA59_04095	COG2190	(PTS) system
EFA59_04105	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
EFA59_04110	COG1309	transcriptional regulator
EFA59_04115	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EFA59_04120	COG4708	membrane
EFA59_04125	COG0481	GTPase activity
EFA59_04155	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EFA59_04160	COG0277	FAD linked oxidase domain protein
EFA59_04195	COG0588	phosphoglycerate mutase activity
EFA59_04200	COG1464	Belongs to the NlpA lipoprotein family
EFA59_04210	COG0071	Belongs to the small heat shock protein (HSP20) family
EFA59_04215	COG0561	phosphatase activity
EFA59_04235	COG3022	response to hydroperoxide
EFA59_04240	COG0406	alpha-ribazole phosphatase activity
EFA59_04330	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
EFA59_04370	COG1309	transcriptional regulator
EFA59_04375	COG2409	Drug exporters of the RND superfamily
EFA59_04375	COG1033	growth of symbiont in host cell
EFA59_04400	COG1401	restriction endodeoxyribonuclease activity
EFA59_04415	COG1609	Transcriptional regulator
EFA59_04425	COG0366	Alpha amylase catalytic
EFA59_04435	COG2223	nitrite transmembrane transporter activity
EFA59_04445	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
EFA59_04450	COG0351	phosphomethylpyrimidine kinase
EFA59_04465	COG1397	ADP-ribosylglycohydrolase
EFA59_04470	COG1719	4-vinyl reductase, 4VR
EFA59_04475	COG0220	tRNA (guanine-N7-)-methyltransferase activity
EFA59_04485	COG1131	(ABC) transporter
EFA59_04490	COG0537	adenosine 5'-monophosphoramidase activity
EFA59_04500	COG0556	nucleotide-excision repair
EFA59_04515	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
EFA59_04525	COG0116	Belongs to the methyltransferase superfamily
EFA59_04535	COG3599	regulation of cell shape
EFA59_04540	COG4474	Belongs to the UPF0398 family
EFA59_04545	COG3331	DNA recombination
EFA59_04555	COG3935	DnaD domain protein
EFA59_04560	COG0017	Asparaginyl-tRNA synthetase
EFA59_04570	COG1199	ATP-dependent helicase activity
EFA59_04570	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
EFA59_04575	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
EFA59_04590	COG1304	FMN binding
EFA59_04600	COG0706	membrane insertase activity
EFA59_04610	COG5002	protein histidine kinase activity
EFA59_04615	COG0745	RESPONSE REGULATOR receiver
EFA59_04630	COG1484	DNA-dependent DNA replication
EFA59_04640	COG0237	dephospho-CoA kinase activity
EFA59_04645	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
EFA59_04695	COG3759	membrane
EFA59_04700	COG0604	alcohol dehydrogenase
EFA59_04765	COG0670	Belongs to the BI1 family
EFA59_04770	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EFA59_04780	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EFA59_04785	COG1363	Peptidase, m42
EFA59_04790	COG0572	uridine kinase
EFA59_04795	COG5002	protein histidine kinase activity
EFA59_04800	COG0745	RESPONSE REGULATOR receiver
EFA59_04810	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EFA59_04815	COG0358	DNA primase activity
EFA59_04840	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EFA59_04840	COG3321	synthase
EFA59_04840	COG4221	oxidoreductase activity
EFA59_04840	COG1028	Short-chain dehydrogenase reductase Sdr
EFA59_04855	COG0446	pyridine nucleotide-disulphide oxidoreductase
EFA59_04865	COG1125	glycine betaine transport
EFA59_04875	COG2217	Heavy metal translocating P-type atpase
EFA59_04935	COG1131	(ABC) transporter
EFA59_04940	COG3655	Transcriptional regulator
EFA59_04975	COG1619	proteins homologs of microcin C7 resistance protein MccF
EFA59_05015	COG1304	FMN binding
EFA59_05020	COG1611	Belongs to the LOG family
EFA59_05035	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EFA59_05040	COG1554	hydrolase, family 65, central catalytic
EFA59_05045	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EFA59_05045	COG1263	PTS System
EFA59_05045	COG2190	(PTS) system
EFA59_05055	COG2188	Transcriptional regulator
EFA59_05070	COG2190	(PTS) system
EFA59_05070	COG1263	PTS System
EFA59_05070	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EFA59_05080	COG0024	Methionine aminopeptidase
EFA59_05090	COG3706	GGDEF domain
EFA59_05115	COG4166	transmembrane transport
EFA59_05130	COG0508	dehydrogenase complex catalyzes the overall conversion of
EFA59_05145	COG0095	Lipoate-protein ligase
EFA59_05150	COG3480	Lon protease (S16) C-terminal proteolytic domain
EFA59_05155	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
EFA59_05160	COG0742	ribosomal rna small subunit methyltransferase
EFA59_05165	COG4471	UPF0298 protein
EFA59_05170	COG0772	Belongs to the SEDS family
EFA59_05180	COG0483	inositol monophosphate 1-phosphatase activity
EFA59_05210	COG1597	lipid kinase activity
EFA59_05220	COG1464	Belongs to the NlpA lipoprotein family
EFA59_05225	COG0446	pyridine nucleotide-disulphide oxidoreductase
EFA59_05240	COG3448	diguanylate cyclase activity
EFA59_05240	COG4175	Glycine betaine
EFA59_05250	COG1227	inorganic diphosphatase activity
EFA59_05260	COG0187	DNA topoisomerase II activity
EFA59_05265	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
EFA59_05275	COG4974	Belongs to the 'phage' integrase family
EFA59_05280	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EFA59_05285	COG0758	DNA mediated transformation
EFA59_05290	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
EFA59_05310	COG2755	lipolytic protein G-D-S-L family
EFA59_05315	COG1307	EDD domain protein, DegV family
EFA59_05320	COG1307	EDD domain protein, DegV family
EFA59_05330	COG3142	Participates in the control of copper homeostasis
EFA59_05340	COG0196	riboflavin kinase activity
EFA59_05345	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
EFA59_05350	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
EFA59_05355	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
EFA59_05365	COG2740	Nucleic-acid-binding protein implicated in transcription termination
EFA59_05370	COG0195	Participates in both transcription termination and antitermination
EFA59_05375	COG0779	Required for maturation of 30S ribosomal subunits
EFA59_05380	COG2239	Acts as a magnesium transporter
EFA59_05385	COG0564	pseudouridine synthase activity
EFA59_05390	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
EFA59_05395	COG2357	RelA SpoT domain protein
EFA59_05410	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
EFA59_05420	COG0546	phosphoglycolate phosphatase activity
EFA59_05470	COG3118	belongs to the thioredoxin family
EFA59_05475	COG1193	negative regulation of DNA recombination
EFA59_05480	COG1286	toxin biosynthetic process
EFA59_05490	COG0218	Necessary for normal cell division and for the maintenance of normal septation
EFA59_05495	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
EFA59_05500	COG0544	peptidyl-prolyl cis-trans isomerase activity
EFA59_05505	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
EFA59_05520	COG0268	Binds directly to 16S ribosomal RNA
EFA59_05525	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
EFA59_05530	COG1466	dna polymerase III delta subunit
EFA59_05535	COG2333	competence protein COMEC
EFA59_05535	COG0658	competence protein
EFA59_05545	COG1596	polysaccharide export
EFA59_05545	COG1555	photosystem II stabilization
EFA59_05565	COG4472	Bacterial protein of unknown function (DUF965)
EFA59_05570	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
EFA59_05575	COG0513	Belongs to the DEAD box helicase family
EFA59_05580	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
EFA59_05585	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
EFA59_05590	COG1862	Preprotein translocase
EFA59_05630	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
EFA59_05635	COG2255	four-way junction helicase activity
EFA59_05640	COG0632	four-way junction helicase activity
EFA59_05655	COG1739	Uncharacterized protein family UPF0029
EFA59_05660	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
EFA59_05665	COG0322	excinuclease ABC activity
EFA59_05670	COG1668	transmembrane transport
EFA59_05675	COG4152	abc transporter atp-binding protein
EFA59_05680	COG1674	ftsk spoiiie
EFA59_05690	COG0628	permease
EFA59_05695	COG2706	6-phosphogluconolactonase activity
EFA59_05700	COG0751	glycine-tRNA ligase activity
EFA59_05705	COG0752	glycyl-tRNA synthetase alpha subunit
EFA59_05710	COG1381	Involved in DNA repair and RecF pathway recombination
EFA59_05715	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
EFA59_05720	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
EFA59_05725	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
EFA59_05730	COG1702	phosphate starvation-inducible protein PhoH
EFA59_05735	COG1610	YqeY-like protein
EFA59_05740	COG0828	Belongs to the bacterial ribosomal protein bS21 family
EFA59_05745	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EFA59_05750	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
EFA59_05755	COG0124	histidyl-tRNA synthetase
EFA59_05760	COG0860	N-Acetylmuramoyl-L-alanine amidase
EFA59_05770	COG3425	synthase
EFA59_05775	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
EFA59_05830	COG2801	Transposase and inactivated derivatives
EFA59_05835	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
EFA59_05840	COG1061	Type III restriction enzyme res subunit
EFA59_05845	COG1002	Type II restriction enzyme, methylase subunits
EFA59_05870	COG2801	Transposase and inactivated derivatives
EFA59_05965	COG0582	viral genome integration into host DNA
EFA59_05980	COG0640	Transcriptional regulator
EFA59_05990	COG1028	Short-chain dehydrogenase reductase Sdr
EFA59_06000	COG1063	alcohol dehydrogenase
EFA59_06005	COG0789	Transcriptional regulator
EFA59_06010	COG0656	L-ascorbic acid biosynthetic process
EFA59_06040	COG1309	transcriptional regulator
EFA59_06050	COG0531	amino acid
EFA59_06055	COG1609	Transcriptional regulator
EFA59_06060	COG0006	proline dipeptidase activity
EFA59_06075	COG1164	Oligoendopeptidase f
EFA59_06085	COG4862	establishment of competence for transformation
EFA59_06090	COG1393	Belongs to the ArsC family
EFA59_06120	COG0561	phosphatase activity
EFA59_06125	COG1970	mechanosensitive ion channel activity
EFA59_06130	COG1428	Deoxynucleoside kinase
EFA59_06145	COG1942	4-Oxalocrotonate Tautomerase
EFA59_06150	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EFA59_06160	COG0335	large ribosomal subunit rRNA binding
EFA59_06165	COG0336	Belongs to the RNA methyltransferase TrmD family
EFA59_06170	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
EFA59_06175	COG0588	phosphoglycerate mutase activity
EFA59_06180	COG0228	four-way junction DNA binding
EFA59_06185	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
EFA59_06195	COG0552	protein localization to endoplasmic reticulum
EFA59_06200	COG1196	nuclear chromosome segregation
EFA59_06205	COG0571	ribonuclease III activity
EFA59_06210	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EFA59_06215	COG0416	fatty acid biosynthetic process
EFA59_06220	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
EFA59_06225	COG1461	Dihydroxyacetone kinase
EFA59_06235	COG0227	Belongs to the bacterial ribosomal protein bL28 family
EFA59_06245	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
EFA59_06250	COG1162	GTPase activity
EFA59_06255	COG2815	serine threonine protein kinase
EFA59_06255	COG0515	serine threonine protein kinase
EFA59_06260	COG0631	protein serine/threonine phosphatase activity
EFA59_06265	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EFA59_06265	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
EFA59_06270	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
EFA59_06275	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
EFA59_06280	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
EFA59_06305	COG2165	general secretion pathway protein
EFA59_06310	COG1459	type II secretion system
EFA59_06315	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EFA59_06320	COG2252	PERMEase
EFA59_06325	COG0217	transcriptional regulatory protein
EFA59_06330	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
EFA59_06340	COG0588	phosphoglycerate mutase activity
EFA59_06345	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
EFA59_06350	COG3599	regulation of cell shape
EFA59_06365	COG1799	cell septum assembly
EFA59_06370	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
EFA59_06380	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
EFA59_06385	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
EFA59_06390	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
EFA59_06395	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EFA59_06410	COG0275	rRNA processing
EFA59_06415	COG2001	Belongs to the MraZ family
EFA59_06425	COG1385	rRNA (uridine-N3-)-methyltransferase activity
EFA59_06430	COG2264	protein methyltransferase activity
EFA59_06440	COG0833	amino acid
EFA59_06450	COG2759	Belongs to the formate--tetrahydrofolate ligase family
EFA59_06460	COG1126	abc transporter atp-binding protein
EFA59_06465	COG0765	amino acid transport
EFA59_06485	COG1077	Cell shape determining protein MreB Mrl
EFA59_06490	COG2003	Belongs to the UPF0758 family
EFA59_06505	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
EFA59_06510	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
EFA59_06520	COG4120	Belongs to the binding-protein-dependent transport system permease family
EFA59_06535	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EFA59_06540	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
EFA59_06560	COG1388	LysM domain
EFA59_06570	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EFA59_06580	COG0494	nUDIX hydrolase
EFA59_06585	COG1278	Cold shock
EFA59_06605	COG1705	Flagellar rod assembly protein muramidase FlgJ
EFA59_06605	COG3951	Flagellar rod assembly protein muramidase FlgJ
EFA59_06610	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
EFA59_06615	COG4988	ABC transporter
EFA59_06620	COG1294	oxidase, subunit
EFA59_06740	COG2183	response to ionizing radiation
EFA59_06750	COG0586	Pfam SNARE associated Golgi protein
EFA59_06760	COG0194	GDP metabolic process
EFA59_06765	COG0497	DNA recombination
EFA59_06770	COG1438	arginine binding
EFA59_06775	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
EFA59_06785	COG1722	exodeoxyribonuclease VII activity
EFA59_06790	COG1570	exodeoxyribonuclease VII activity
EFA59_06795	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
EFA59_06800	COG4720	Psort location CytoplasmicMembrane, score
EFA59_06810	COG0363	glucosamine-6-phosphate deaminase activity
EFA59_06815	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
EFA59_06820	COG0716	FMN binding
EFA59_06825	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
EFA59_06830	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
EFA59_06840	COG1323	Belongs to the UPF0348 family
EFA59_06850	COG0799	negative regulation of ribosome biogenesis
EFA59_06855	COG1713	HD superfamily hydrolase involved in NAD metabolism
EFA59_06860	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
EFA59_06870	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
EFA59_06880	COG1181	Belongs to the D-alanine--D-alanine ligase family
EFA59_06890	COG0531	amino acid
EFA59_06895	COG0459	protein refolding
EFA59_06900	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
EFA59_06905	COG0488	(ABC) transporter
EFA59_06910	COG0285	dihydrofolate synthase activity
EFA59_06915	COG0525	valine-tRNA ligase activity
EFA59_06925	COG1272	protein, Hemolysin III
EFA59_06940	COG0589	response to stress
EFA59_06950	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
EFA59_06965	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
EFA59_06970	COG3557	Belongs to the UPF0374 family
EFA59_06985	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
EFA59_06990	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
EFA59_06995	COG0581	inorganic phosphate transmembrane transporter activity
EFA59_07000	COG0573	inorganic phosphate transmembrane transporter activity
EFA59_07005	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
EFA59_07015	COG0647	UMP catabolic process
EFA59_07020	COG4470	Protein conserved in bacteria
EFA59_07025	COG0737	Belongs to the 5'-nucleotidase family
EFA59_07040	COG0006	proline dipeptidase activity
EFA59_07045	COG4948	Mandelate Racemase Muconate Lactonizing
EFA59_07055	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
EFA59_07060	COG1169	isochorismate synthase
EFA59_07065	COG0211	Belongs to the bacterial ribosomal protein bL27 family
EFA59_07070	COG0261	This protein binds to 23S rRNA in the presence of protein L20
EFA59_07100	COG0174	glutamine synthetase
EFA59_07105	COG0789	Transcriptional regulator
EFA59_07110	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
EFA59_07115	COG0584	glycerophosphoryl diester phosphodiesterase
EFA59_07135	COG1940	carbohydrate kinase activity
EFA59_07145	COG0705	Rhomboid family
EFA59_07150	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
EFA59_07155	COG0768	penicillin binding
EFA59_07165	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EFA59_07170	COG0514	ATP-dependent DNA helicase (RecQ)
EFA59_07175	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
EFA59_07180	COG0072	phenylalanine-tRNA ligase activity
EFA59_07180	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EFA59_07185	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
EFA59_07190	COG1733	regulation of RNA biosynthetic process
EFA59_07200	COG4975	Glucose uptake
EFA59_07210	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EFA59_07220	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
EFA59_07235	COG4956	integral membrane protein (PIN domain superfamily)
EFA59_07245	COG0756	dUTP diphosphatase activity
EFA59_07255	COG0791	NLP P60 protein
EFA59_07280	COG0604	alcohol dehydrogenase
EFA59_07285	COG3527	Alpha-acetolactate decarboxylase
EFA59_07290	COG0028	Belongs to the TPP enzyme family
EFA59_07320	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EFA59_07325	COG0740	serine-type endopeptidase activity
EFA59_07330	COG1481	regulation of sporulation
EFA59_07335	COG0391	Required for morphogenesis under gluconeogenic growth conditions
EFA59_07340	COG1660	Displays ATPase and GTPase activities
EFA59_07350	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
EFA59_07375	COG1573	uracil-dna glycosylase
EFA59_07400	COG3775	system Galactitol-specific IIC component
EFA59_07415	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EFA59_07415	COG3711	transcriptional antiterminator
EFA59_07425	COG0667	Aldo Keto reductase
EFA59_07430	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
EFA59_07455	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
EFA59_07470	COG2169	Transcriptional regulator
EFA59_07470	COG1917	Cupin 2, conserved barrel domain protein
EFA59_07480	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
EFA59_07485	COG0149	triose-phosphate isomerase activity
EFA59_07495	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
EFA59_07500	COG2186	Transcriptional regulator
EFA59_07505	COG2610	gluconate transmembrane transporter activity
EFA59_07510	COG0800	Aldolase
EFA59_07520	COG4948	Mandelate Racemase Muconate Lactonizing
EFA59_07535	COG4166	transmembrane transport
EFA59_07550	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EFA59_07575	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
EFA59_07580	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
EFA59_07585	COG0101	tRNA pseudouridine synthase activity
EFA59_07595	COG1122	ATPase activity
EFA59_07600	COG1122	ATPase activity
EFA59_07610	COG1252	NADH dehydrogenase
EFA59_07615	COG0803	Belongs to the bacterial solute-binding protein 9 family
EFA59_07620	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EFA59_07625	COG1121	(ABC) transporter
EFA59_07635	COG0222	ribosome binding
EFA59_07640	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
EFA59_07645	COG0081	regulation of translation
EFA59_07650	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
EFA59_07655	COG0250	Participates in transcription elongation, termination and antitermination
EFA59_07665	COG0267	Belongs to the bacterial ribosomal protein bL33 family
EFA59_07675	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EFA59_07680	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
EFA59_07685	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
EFA59_07690	COG0284	orotidine-5'-phosphate decarboxylase activity
EFA59_07695	COG0167	dihydroorotate dehydrogenase activity
EFA59_07700	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
EFA59_07705	COG0505	Belongs to the CarA family
EFA59_07715	COG0540	Belongs to the ATCase OTCase family
EFA59_07720	COG0517	IMP dehydrogenase activity
EFA59_07720	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
EFA59_07725	COG2877	3-deoxy-8-phosphooctulonate synthase activity
EFA59_07730	COG1854	S-ribosylhomocysteine lyase activity
EFA59_07735	COG0215	cysteine-tRNA ligase activity
EFA59_07740	COG0667	Aldo Keto reductase
EFA59_07745	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
EFA59_07750	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
EFA59_07760	COG1464	Belongs to the NlpA lipoprotein family
EFA59_07765	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
EFA59_07790	COG0203	ribosomal protein L17
EFA59_07795	COG0202	RNA polymerase activity
EFA59_07800	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
EFA59_07805	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
EFA59_07810	COG0257	Belongs to the bacterial ribosomal protein bL36 family
EFA59_07815	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
EFA59_07820	COG0563	adenylate kinase activity
EFA59_07830	COG0200	Binds to the 23S rRNA
EFA59_07840	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
EFA59_07845	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
EFA59_07850	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
EFA59_07855	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
EFA59_07860	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
EFA59_07865	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
EFA59_07870	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
EFA59_07880	COG0255	Belongs to the universal ribosomal protein uL29 family
EFA59_07885	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
EFA59_07890	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
EFA59_07895	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
EFA59_07900	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
EFA59_07905	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
EFA59_07910	COG0089	rRNA binding
EFA59_07920	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
EFA59_07925	COG0051	transcription antitermination factor activity, RNA binding
EFA59_07930	COG0142	geranyltranstransferase activity
EFA59_07935	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
EFA59_07950	COG1214	PFAM Peptidase M22, glycoprotease
EFA59_07955	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
EFA59_07975	COG3870	Protein conserved in bacteria
EFA59_07980	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
EFA59_07990	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
EFA59_08000	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
EFA59_08015	COG2813	Specifically methylates the guanine in position
EFA59_08025	COG0488	(ABC) transporter
EFA59_08035	COG0640	Transcriptional regulator
EFA59_08045	COG2814	Major facilitator Superfamily
EFA59_08050	COG1983	PspC domain protein
EFA59_08055	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EFA59_08075	COG0500	methyltransferase
EFA59_08080	COG1979	alcohol dehydrogenase
EFA59_08085	COG1979	alcohol dehydrogenase
EFA59_08090	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
EFA59_08095	COG0085	RNA polymerase activity
EFA59_08100	COG0542	response to heat
EFA59_08105	COG4463	regulation of RNA biosynthetic process
EFA59_08130	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
EFA59_08135	COG1428	Deoxynucleoside kinase
EFA59_08145	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
EFA59_08150	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
EFA59_08155	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
EFA59_08160	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
EFA59_08165	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
EFA59_08170	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
EFA59_08175	COG0356	it plays a direct role in the translocation of protons across the membrane
EFA59_08180	COG2233	PERMEase
EFA59_08190	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
EFA59_08195	COG0009	L-threonylcarbamoyladenylate synthase
EFA59_08200	COG2890	protein-(glutamine-N5) methyltransferase activity
EFA59_08210	COG1435	thymidine kinase activity
EFA59_08215	COG3442	glutamine amidotransferase
EFA59_08220	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
EFA59_08240	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
EFA59_08245	COG2252	PERMEase
EFA59_08250	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
EFA59_08260	COG1132	(ABC) transporter
EFA59_08265	COG1132	(ABC) transporter
EFA59_08275	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EFA59_08280	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EFA59_08285	COG2723	6-phospho-beta-galactosidase activity
EFA59_08290	COG1447	Phosphotransferase system cellobiose-specific component IIA
EFA59_08295	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EFA59_08300	COG2723	6-phospho-beta-galactosidase activity
EFA59_08305	COG2188	Transcriptional regulator
EFA59_08315	COG0588	phosphoglycerate mutase activity
EFA59_08330	COG0708	Exodeoxyribonuclease III
EFA59_08335	COG1454	alcohol dehydrogenase
EFA59_08335	COG1012	belongs to the aldehyde dehydrogenase family
EFA59_08340	COG2217	Heavy metal translocating P-type atpase
EFA59_08360	COG3590	peptidase
EFA59_08370	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
EFA59_08375	COG2188	Transcriptional regulator
EFA59_08380	COG1418	mRNA catabolic process
EFA59_08415	COG0656	L-ascorbic acid biosynthetic process
EFA59_08420	COG2160	L-arabinose isomerase activity
EFA59_08445	COG0534	Mate efflux family protein
EFA59_08455	COG0488	(ABC) transporter
EFA59_08465	COG1121	(ABC) transporter
EFA59_08480	COG2755	lipolytic protein G-D-S-L family
EFA59_08480	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
EFA59_08500	COG3104	oligopeptide transport
EFA59_08530	COG0671	phosphoesterase, PA-phosphatase related
EFA59_08540	COG0745	RESPONSE REGULATOR receiver
EFA59_08550	COG0012	GTP binding
EFA59_08560	COG1475	DNA binding
EFA59_08565	COG1192	Involved in chromosome partitioning
EFA59_08570	COG0357	Ribosomal RNA small subunit methyltransferase G
EFA59_08580	COG1194	a g-specific adenine glycosylase
EFA59_08590	COG5002	protein histidine kinase activity
EFA59_08595	COG0745	RESPONSE REGULATOR receiver
EFA59_08600	COG0531	amino acid
EFA59_08610	COG0318	PFAM AMP-dependent synthetase and ligase
EFA59_08615	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
EFA59_08630	COG4443	Transcriptional Coactivator p15 (PC4)
EFA59_08635	COG0252	asparaginase activity
EFA59_08645	COG1113	amino acid transport
EFA59_08655	COG0531	amino acid
EFA59_08665	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
EFA59_08670	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
EFA59_08680	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
EFA59_08690	COG0477	Major facilitator Superfamily
EFA59_08695	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EFA59_08695	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
EFA59_08710	COG3716	PTS system mannose fructose sorbose family IID component
EFA59_08725	COG2188	Transcriptional regulator
EFA59_08730	COG2188	Transcriptional regulator
EFA59_08735	COG0531	amino acid
EFA59_08750	COG2855	membrane
EFA59_08755	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EFA59_08770	COG1012	belongs to the aldehyde dehydrogenase family
EFA59_08830	COG1113	amino acid transport
EFA59_08845	COG0628	permease
EFA59_08855	COG1254	Belongs to the acylphosphatase family
EFA59_08860	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EFA59_08865	COG0765	amino acid transport
EFA59_08870	COG1126	abc transporter atp-binding protein
EFA59_08880	COG0656	L-ascorbic acid biosynthetic process
EFA59_08895	COG0277	FAD linked oxidase domain protein
EFA59_08900	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
EFA59_08905	COG1122	ATPase activity
EFA59_08910	COG4720	Psort location CytoplasmicMembrane, score
EFA59_08915	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
EFA59_08920	COG2357	RelA SpoT domain protein
EFA59_08925	COG1744	ABC transporter substrate-binding protein PnrA-like
EFA59_08950	COG3048	D-serine ammonia-lyase activity
EFA59_08965	COG1136	(ABC) transporter
EFA59_08985	COG0789	Transcriptional regulator
EFA59_08990	COG0477	Major facilitator Superfamily
EFA59_08995	COG1827	regulation of RNA biosynthetic process
EFA59_09005	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
EFA59_09025	COG0402	S-adenosylhomocysteine deaminase activity
EFA59_09030	COG1268	BioY protein
EFA59_09045	COG1070	Carbohydrate kinase
EFA59_09060	COG2211	Major facilitator Superfamily
EFA59_09060	COG2190	(PTS) system
EFA59_09070	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
EFA59_09095	COG1609	Transcriptional regulator
EFA59_09100	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
EFA59_09105	COG1881	PFAM PEBP family protein
EFA59_09110	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EFA59_09115	COG0436	Aminotransferase
EFA59_09120	COG0110	maltose O-acetyltransferase activity
EFA59_09125	COG0110	maltose O-acetyltransferase activity
EFA59_09130	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
EFA59_09140	COG0531	amino acid
EFA59_09165	COG2252	PERMEase
EFA59_09180	COG1131	(ABC) transporter
EFA59_09185	COG2186	Transcriptional regulator
EFA59_09190	COG0328	RNA-DNA hybrid ribonuclease activity
EFA59_09195	COG0561	phosphatase activity
EFA59_09200	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EFA59_09215	COG0028	Belongs to the TPP enzyme family
EFA59_09230	COG4221	oxidoreductase activity
EFA59_09235	COG0789	Transcriptional regulator
EFA59_09240	COG1301	dicarboxylic acid transport
EFA59_09245	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EFA59_09250	COG2022	thiamine diphosphate biosynthetic process
EFA59_09255	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EFA59_09275	COG1113	amino acid transport
EFA59_09280	COG0569	domain protein
EFA59_09285	COG5386	Cell surface protein
EFA59_09305	COG1120	ATPase activity
EFA59_09320	COG0706	membrane insertase activity
EFA59_09325	COG0594	ribonuclease P activity
EFA59_09330	COG0230	Belongs to the bacterial ribosomal protein bL34 family
EFA59_09345	COG0390	transport system, permease component
EFA59_09350	COG4619	ABC transporter
EFA59_09360	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EFA59_09365	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
EFA59_09410	COG0668	transmembrane transport
EFA59_09440	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
EFA59_09460	COG1733	regulation of RNA biosynthetic process
EFA59_09465	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
EFA59_09480	COG0693	protein deglycase activity
EFA59_09485	COG1733	regulation of RNA biosynthetic process
EFA59_09505	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EFA59_09520	COG0604	alcohol dehydrogenase
EFA59_09545	COG0783	Belongs to the Dps family
EFA59_09550	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EFA59_09570	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EFA59_09595	COG2801	Transposase and inactivated derivatives
EFA59_09630	COG2801	Transposase and inactivated derivatives
EFA59_09635	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
EFA59_09660	COG0640	Transcriptional regulator
EFA59_09670	COG3118	belongs to the thioredoxin family
EFA59_09675	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins