locus-tag	class	description
GZH44_00010	COG0604	alcohol dehydrogenase
GZH44_00060	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GZH44_00060	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GZH44_00070	COG0670	Belongs to the BI1 family
GZH44_00075	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GZH44_00085	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GZH44_00090	COG1363	Peptidase, m42
GZH44_00095	COG0572	uridine kinase
GZH44_00100	COG5002	protein histidine kinase activity
GZH44_00105	COG0745	RESPONSE REGULATOR receiver
GZH44_00115	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GZH44_00120	COG0358	DNA primase activity
GZH44_00140	COG1216	Glycosyl transferase, family 2
GZH44_00150	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
GZH44_00175	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
GZH44_00180	COG0438	transferase activity, transferring glycosyl groups
GZH44_00185	COG2801	Transposase and inactivated derivatives
GZH44_00195	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GZH44_00285	COG0542	response to heat
GZH44_00350	COG0446	pyridine nucleotide-disulphide oxidoreductase
GZH44_00360	COG1125	glycine betaine transport
GZH44_00370	COG2217	Heavy metal translocating P-type atpase
GZH44_00400	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
GZH44_00405	COG0738	Major facilitator superfamily
GZH44_00410	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GZH44_00435	COG1228	amidohydrolase
GZH44_00440	COG4166	transmembrane transport
GZH44_00555	COG1131	(ABC) transporter
GZH44_00560	COG3655	Transcriptional regulator
GZH44_00600	COG1619	proteins homologs of microcin C7 resistance protein MccF
GZH44_00640	COG1304	FMN binding
GZH44_00645	COG1611	Belongs to the LOG family
GZH44_00660	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GZH44_00665	COG1554	hydrolase, family 65, central catalytic
GZH44_00670	COG2190	(PTS) system
GZH44_00670	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GZH44_00670	COG1263	PTS System
GZH44_00680	COG2188	Transcriptional regulator
GZH44_00705	COG0024	Methionine aminopeptidase
GZH44_00715	COG3706	GGDEF domain
GZH44_00735	COG0463	Glycosyl transferase, family 2
GZH44_00735	COG1216	Glycosyl transferase, family 2
GZH44_00740	COG4166	transmembrane transport
GZH44_00755	COG0508	dehydrogenase complex catalyzes the overall conversion of
GZH44_00770	COG0095	Lipoate-protein ligase
GZH44_00775	COG3480	Lon protease (S16) C-terminal proteolytic domain
GZH44_00780	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
GZH44_00785	COG0742	ribosomal rna small subunit methyltransferase
GZH44_00790	COG4471	UPF0298 protein
GZH44_00795	COG0772	Belongs to the SEDS family
GZH44_00800	COG1217	gtp-binding protein TYPA
GZH44_00805	COG0483	inositol monophosphate 1-phosphatase activity
GZH44_00825	COG5503	Protein of unknown function (DUF1447)
GZH44_00835	COG1597	lipid kinase activity
GZH44_00845	COG1464	Belongs to the NlpA lipoprotein family
GZH44_00850	COG0446	pyridine nucleotide-disulphide oxidoreductase
GZH44_00865	COG4175	Glycine betaine
GZH44_00865	COG3448	diguanylate cyclase activity
GZH44_00875	COG1227	inorganic diphosphatase activity
GZH44_00885	COG0187	DNA topoisomerase II activity
GZH44_00890	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
GZH44_00900	COG4974	Belongs to the 'phage' integrase family
GZH44_00905	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GZH44_00910	COG0758	DNA mediated transformation
GZH44_00915	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GZH44_00925	COG4479	Belongs to the UPF0346 family
GZH44_00935	COG2755	lipolytic protein G-D-S-L family
GZH44_00940	COG1307	EDD domain protein, DegV family
GZH44_00945	COG1307	EDD domain protein, DegV family
GZH44_00955	COG3142	Participates in the control of copper homeostasis
GZH44_00965	COG0196	riboflavin kinase activity
GZH44_00970	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GZH44_00975	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GZH44_00980	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GZH44_00990	COG2740	Nucleic-acid-binding protein implicated in transcription termination
GZH44_00995	COG0195	Participates in both transcription termination and antitermination
GZH44_01000	COG0779	Required for maturation of 30S ribosomal subunits
GZH44_01005	COG2239	Acts as a magnesium transporter
GZH44_01010	COG0564	pseudouridine synthase activity
GZH44_01015	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GZH44_01020	COG2357	RelA SpoT domain protein
GZH44_01035	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
GZH44_01045	COG0546	phosphoglycolate phosphatase activity
GZH44_01095	COG3118	belongs to the thioredoxin family
GZH44_01100	COG1193	negative regulation of DNA recombination
GZH44_01105	COG1286	toxin biosynthetic process
GZH44_01115	COG0218	Necessary for normal cell division and for the maintenance of normal septation
GZH44_01120	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
GZH44_01125	COG0544	peptidyl-prolyl cis-trans isomerase activity
GZH44_01130	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GZH44_01145	COG0268	Binds directly to 16S ribosomal RNA
GZH44_01150	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
GZH44_01155	COG1466	dna polymerase III delta subunit
GZH44_01160	COG0658	competence protein
GZH44_01160	COG2333	competence protein COMEC
GZH44_01165	COG1555	photosystem II stabilization
GZH44_01165	COG1596	polysaccharide export
GZH44_01185	COG4472	Bacterial protein of unknown function (DUF965)
GZH44_01190	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GZH44_01195	COG0513	Belongs to the DEAD box helicase family
GZH44_01200	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
GZH44_01205	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GZH44_01210	COG1862	Preprotein translocase
GZH44_01250	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
GZH44_01255	COG2255	four-way junction helicase activity
GZH44_01260	COG0632	four-way junction helicase activity
GZH44_01275	COG1739	Uncharacterized protein family UPF0029
GZH44_01280	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GZH44_01285	COG0322	excinuclease ABC activity
GZH44_01290	COG1668	transmembrane transport
GZH44_01295	COG4152	abc transporter atp-binding protein
GZH44_01300	COG1674	ftsk spoiiie
GZH44_01310	COG0628	permease
GZH44_01315	COG2706	6-phosphogluconolactonase activity
GZH44_01320	COG0751	glycine-tRNA ligase activity
GZH44_01325	COG0752	glycyl-tRNA synthetase alpha subunit
GZH44_01330	COG1381	Involved in DNA repair and RecF pathway recombination
GZH44_01335	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
GZH44_01340	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
GZH44_01345	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
GZH44_01350	COG1702	phosphate starvation-inducible protein PhoH
GZH44_01355	COG1610	YqeY-like protein
GZH44_01360	COG0828	Belongs to the bacterial ribosomal protein bS21 family
GZH44_01365	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GZH44_01370	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
GZH44_01375	COG0124	histidyl-tRNA synthetase
GZH44_01380	COG0860	N-Acetylmuramoyl-L-alanine amidase
GZH44_01390	COG3425	synthase
GZH44_01395	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GZH44_01430	COG0640	Transcriptional regulator
GZH44_01440	COG1028	Short-chain dehydrogenase reductase Sdr
GZH44_01450	COG1063	alcohol dehydrogenase
GZH44_01455	COG0789	Transcriptional regulator
GZH44_01460	COG0656	L-ascorbic acid biosynthetic process
GZH44_01490	COG1309	transcriptional regulator
GZH44_01500	COG0531	amino acid
GZH44_01505	COG1609	Transcriptional regulator
GZH44_01510	COG0006	proline dipeptidase activity
GZH44_01525	COG1164	Oligoendopeptidase f
GZH44_01535	COG4862	establishment of competence for transformation
GZH44_01540	COG1393	Belongs to the ArsC family
GZH44_01570	COG0561	phosphatase activity
GZH44_01575	COG1970	mechanosensitive ion channel activity
GZH44_01580	COG1428	Deoxynucleoside kinase
GZH44_01595	COG1942	4-Oxalocrotonate Tautomerase
GZH44_01600	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GZH44_01610	COG0335	large ribosomal subunit rRNA binding
GZH44_01615	COG0336	Belongs to the RNA methyltransferase TrmD family
GZH44_01620	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
GZH44_01625	COG0588	phosphoglycerate mutase activity
GZH44_01630	COG0228	four-way junction DNA binding
GZH44_01635	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GZH44_01640	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
GZH44_01645	COG0552	protein localization to endoplasmic reticulum
GZH44_01650	COG1196	nuclear chromosome segregation
GZH44_01655	COG0571	ribonuclease III activity
GZH44_01660	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GZH44_01665	COG0416	fatty acid biosynthetic process
GZH44_01670	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GZH44_01675	COG1461	Dihydroxyacetone kinase
GZH44_01685	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GZH44_01695	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GZH44_01700	COG1162	GTPase activity
GZH44_01705	COG0515	serine threonine protein kinase
GZH44_01705	COG2815	serine threonine protein kinase
GZH44_01710	COG0631	protein serine/threonine phosphatase activity
GZH44_01715	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GZH44_01715	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GZH44_01720	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GZH44_01725	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GZH44_01730	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GZH44_01760	COG2165	general secretion pathway protein
GZH44_01765	COG1459	type II secretion system
GZH44_01770	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GZH44_01775	COG2252	PERMEase
GZH44_01780	COG0217	transcriptional regulatory protein
GZH44_01785	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GZH44_01795	COG0588	phosphoglycerate mutase activity
GZH44_01805	COG3599	regulation of cell shape
GZH44_01820	COG1799	cell septum assembly
GZH44_01825	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GZH44_01835	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
GZH44_01840	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GZH44_01845	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GZH44_01850	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GZH44_01855	COG0768	penicillin binding
GZH44_01865	COG0275	rRNA processing
GZH44_01870	COG2001	Belongs to the MraZ family
GZH44_01880	COG1385	rRNA (uridine-N3-)-methyltransferase activity
GZH44_01885	COG2264	protein methyltransferase activity
GZH44_01895	COG0833	amino acid
GZH44_01905	COG2759	Belongs to the formate--tetrahydrofolate ligase family
GZH44_01910	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GZH44_01915	COG1126	abc transporter atp-binding protein
GZH44_01920	COG0765	amino acid transport
GZH44_01940	COG1077	Cell shape determining protein MreB Mrl
GZH44_01945	COG2003	Belongs to the UPF0758 family
GZH44_01960	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GZH44_01965	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GZH44_01975	COG4120	Belongs to the binding-protein-dependent transport system permease family
GZH44_01990	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GZH44_01995	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GZH44_02015	COG1388	LysM domain
GZH44_02025	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GZH44_02035	COG0494	nUDIX hydrolase
GZH44_02040	COG1278	Cold shock
GZH44_02060	COG3951	Flagellar rod assembly protein muramidase FlgJ
GZH44_02060	COG1705	Flagellar rod assembly protein muramidase FlgJ
GZH44_02065	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
GZH44_02070	COG4988	ABC transporter
GZH44_02075	COG1294	oxidase, subunit
GZH44_02080	COG1271	oxidase subunit
GZH44_02195	COG2183	response to ionizing radiation
GZH44_02200	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GZH44_02205	COG0586	Pfam SNARE associated Golgi protein
GZH44_02215	COG0194	GDP metabolic process
GZH44_02220	COG0497	DNA recombination
GZH44_02225	COG1438	arginine binding
GZH44_02230	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
GZH44_02240	COG1722	exodeoxyribonuclease VII activity
GZH44_02245	COG1570	exodeoxyribonuclease VII activity
GZH44_02250	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GZH44_02255	COG4720	Psort location CytoplasmicMembrane, score
GZH44_02265	COG0363	glucosamine-6-phosphate deaminase activity
GZH44_02270	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GZH44_02275	COG0716	FMN binding
GZH44_02280	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
GZH44_02285	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
GZH44_02295	COG1323	Belongs to the UPF0348 family
GZH44_02305	COG0799	negative regulation of ribosome biogenesis
GZH44_02310	COG1713	HD superfamily hydrolase involved in NAD metabolism
GZH44_02315	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GZH44_02325	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
GZH44_02335	COG1181	Belongs to the D-alanine--D-alanine ligase family
GZH44_02345	COG0531	amino acid
GZH44_02350	COG0459	protein refolding
GZH44_02355	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GZH44_02360	COG0488	(ABC) transporter
GZH44_02365	COG0285	dihydrofolate synthase activity
GZH44_02370	COG0525	valine-tRNA ligase activity
GZH44_02380	COG1272	protein, Hemolysin III
GZH44_02405	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GZH44_02420	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
GZH44_02425	COG3557	Belongs to the UPF0374 family
GZH44_02440	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GZH44_02445	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GZH44_02450	COG0581	inorganic phosphate transmembrane transporter activity
GZH44_02455	COG0573	inorganic phosphate transmembrane transporter activity
GZH44_02475	COG0647	UMP catabolic process
GZH44_02480	COG4470	Protein conserved in bacteria
GZH44_02485	COG0737	Belongs to the 5'-nucleotidase family
GZH44_02500	COG0006	proline dipeptidase activity
GZH44_02505	COG4948	Mandelate Racemase Muconate Lactonizing
GZH44_02515	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
GZH44_02520	COG1169	isochorismate synthase
GZH44_02525	COG0211	Belongs to the bacterial ribosomal protein bL27 family
GZH44_02530	COG0261	This protein binds to 23S rRNA in the presence of protein L20
GZH44_02560	COG0174	glutamine synthetase
GZH44_02565	COG0789	Transcriptional regulator
GZH44_02570	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GZH44_02575	COG0584	glycerophosphoryl diester phosphodiesterase
GZH44_02595	COG1940	carbohydrate kinase activity
GZH44_02605	COG0705	Rhomboid family
GZH44_02610	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GZH44_02615	COG0768	penicillin binding
GZH44_02625	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GZH44_02630	COG0514	ATP-dependent DNA helicase (RecQ)
GZH44_02635	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GZH44_02640	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GZH44_02640	COG0072	phenylalanine-tRNA ligase activity
GZH44_02645	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GZH44_02650	COG1733	regulation of RNA biosynthetic process
GZH44_02660	COG4975	Glucose uptake
GZH44_02670	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GZH44_02680	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
GZH44_02695	COG4956	integral membrane protein (PIN domain superfamily)
GZH44_02705	COG0756	dUTP diphosphatase activity
GZH44_02715	COG0791	NLP P60 protein
GZH44_02720	COG3942	CHAP domain
GZH44_02720	COG1388	LysM domain
GZH44_02725	COG0542	response to heat
GZH44_02730	COG0604	alcohol dehydrogenase
GZH44_02735	COG3527	Alpha-acetolactate decarboxylase
GZH44_02740	COG0028	Belongs to the TPP enzyme family
GZH44_02770	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GZH44_02775	COG0740	serine-type endopeptidase activity
GZH44_02780	COG1481	regulation of sporulation
GZH44_02785	COG0391	Required for morphogenesis under gluconeogenic growth conditions
GZH44_02790	COG1660	Displays ATPase and GTPase activities
GZH44_02800	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GZH44_02825	COG1573	uracil-dna glycosylase
GZH44_02830	COG0366	Alpha amylase catalytic
GZH44_02850	COG3775	system Galactitol-specific IIC component
GZH44_02865	COG3711	transcriptional antiterminator
GZH44_02865	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GZH44_02875	COG0667	Aldo Keto reductase
GZH44_02880	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GZH44_02915	COG2169	Transcriptional regulator
GZH44_02915	COG1917	Cupin 2, conserved barrel domain protein
GZH44_02925	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GZH44_02930	COG0149	triose-phosphate isomerase activity
GZH44_02940	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GZH44_02945	COG2186	Transcriptional regulator
GZH44_02950	COG2610	gluconate transmembrane transporter activity
GZH44_02955	COG0800	Aldolase
GZH44_02965	COG4948	Mandelate Racemase Muconate Lactonizing
GZH44_02980	COG4166	transmembrane transport
GZH44_02995	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GZH44_03015	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GZH44_03020	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GZH44_03025	COG0101	tRNA pseudouridine synthase activity
GZH44_03035	COG1122	ATPase activity
GZH44_03040	COG1122	ATPase activity
GZH44_03050	COG1252	NADH dehydrogenase
GZH44_03055	COG0803	Belongs to the bacterial solute-binding protein 9 family
GZH44_03060	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GZH44_03065	COG1121	(ABC) transporter
GZH44_03075	COG0222	ribosome binding
GZH44_03080	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GZH44_03085	COG0081	regulation of translation
GZH44_03090	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
GZH44_03095	COG0250	Participates in transcription elongation, termination and antitermination
GZH44_03105	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GZH44_03115	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GZH44_03120	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
GZH44_03125	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
GZH44_03130	COG0284	orotidine-5'-phosphate decarboxylase activity
GZH44_03135	COG0167	dihydroorotate dehydrogenase activity
GZH44_03140	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GZH44_03145	COG0505	Belongs to the CarA family
GZH44_03155	COG0540	Belongs to the ATCase OTCase family
GZH44_03160	COG0517	IMP dehydrogenase activity
GZH44_03160	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
GZH44_03165	COG2877	3-deoxy-8-phosphooctulonate synthase activity
GZH44_03170	COG1854	S-ribosylhomocysteine lyase activity
GZH44_03175	COG0215	cysteine-tRNA ligase activity
GZH44_03180	COG0667	Aldo Keto reductase
GZH44_03185	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
GZH44_03190	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
GZH44_03200	COG1464	Belongs to the NlpA lipoprotein family
GZH44_03205	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GZH44_03230	COG0203	ribosomal protein L17
GZH44_03235	COG0202	RNA polymerase activity
GZH44_03240	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GZH44_03245	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GZH44_03250	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GZH44_03255	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GZH44_03260	COG0563	adenylate kinase activity
GZH44_03270	COG0200	Binds to the 23S rRNA
GZH44_03275	COG1841	ribosomal large subunit assembly
GZH44_03280	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
GZH44_03285	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
GZH44_03290	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
GZH44_03295	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GZH44_03300	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GZH44_03305	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
GZH44_03310	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
GZH44_03320	COG0255	Belongs to the universal ribosomal protein uL29 family
GZH44_03325	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
GZH44_03330	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
GZH44_03335	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
GZH44_03340	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
GZH44_03345	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
GZH44_03350	COG0089	rRNA binding
GZH44_03360	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GZH44_03365	COG0051	transcription antitermination factor activity, RNA binding
GZH44_03370	COG0142	geranyltranstransferase activity
GZH44_03375	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GZH44_03390	COG1214	PFAM Peptidase M22, glycoprotease
GZH44_03395	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GZH44_03415	COG3870	Protein conserved in bacteria
GZH44_03420	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GZH44_03430	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GZH44_03435	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
GZH44_03455	COG2813	Specifically methylates the guanine in position
GZH44_03465	COG0488	(ABC) transporter
GZH44_03475	COG0640	Transcriptional regulator
GZH44_03485	COG2814	Major facilitator Superfamily
GZH44_03490	COG1983	PspC domain protein
GZH44_03495	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GZH44_03515	COG0500	methyltransferase
GZH44_03520	COG1979	alcohol dehydrogenase
GZH44_03525	COG1979	alcohol dehydrogenase
GZH44_03530	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GZH44_03535	COG0085	RNA polymerase activity
GZH44_03540	COG0542	response to heat
GZH44_03545	COG4463	regulation of RNA biosynthetic process
GZH44_03570	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GZH44_03575	COG1428	Deoxynucleoside kinase
GZH44_03585	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
GZH44_03590	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GZH44_03595	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
GZH44_03600	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GZH44_03605	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
GZH44_03610	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GZH44_03615	COG0356	it plays a direct role in the translocation of protons across the membrane
GZH44_03620	COG2233	PERMEase
GZH44_03625	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GZH44_03630	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GZH44_03635	COG0009	L-threonylcarbamoyladenylate synthase
GZH44_03640	COG2890	protein-(glutamine-N5) methyltransferase activity
GZH44_03650	COG1435	thymidine kinase activity
GZH44_03655	COG3442	glutamine amidotransferase
GZH44_03660	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GZH44_03665	COG1482	cell wall glycoprotein biosynthetic process
GZH44_03685	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
GZH44_03690	COG2252	PERMEase
GZH44_03695	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GZH44_03705	COG1132	(ABC) transporter
GZH44_03710	COG1132	(ABC) transporter
GZH44_03720	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GZH44_03725	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GZH44_03730	COG2723	6-phospho-beta-galactosidase activity
GZH44_03735	COG1447	Phosphotransferase system cellobiose-specific component IIA
GZH44_03740	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GZH44_03745	COG2723	6-phospho-beta-galactosidase activity
GZH44_03750	COG2188	Transcriptional regulator
GZH44_03755	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GZH44_03760	COG0588	phosphoglycerate mutase activity
GZH44_03775	COG0708	Exodeoxyribonuclease III
GZH44_03780	COG1454	alcohol dehydrogenase
GZH44_03780	COG1012	belongs to the aldehyde dehydrogenase family
GZH44_03785	COG2217	Heavy metal translocating P-type atpase
GZH44_03805	COG3590	peptidase
GZH44_03815	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
GZH44_03820	COG2188	Transcriptional regulator
GZH44_03825	COG1418	mRNA catabolic process
GZH44_03845	COG0765	amino acid transport
GZH44_03865	COG0656	L-ascorbic acid biosynthetic process
GZH44_03870	COG2160	L-arabinose isomerase activity
GZH44_03890	COG0534	Mate efflux family protein
GZH44_03900	COG0488	(ABC) transporter
GZH44_03910	COG1121	(ABC) transporter
GZH44_03925	COG2755	lipolytic protein G-D-S-L family
GZH44_03925	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
GZH44_03945	COG3104	oligopeptide transport
GZH44_03975	COG0671	phosphoesterase, PA-phosphatase related
GZH44_03985	COG0745	RESPONSE REGULATOR receiver
GZH44_03995	COG0012	GTP binding
GZH44_04005	COG1475	DNA binding
GZH44_04010	COG1192	Involved in chromosome partitioning
GZH44_04015	COG0357	Ribosomal RNA small subunit methyltransferase G
GZH44_04025	COG1194	a g-specific adenine glycosylase
GZH44_04035	COG5002	protein histidine kinase activity
GZH44_04040	COG0745	RESPONSE REGULATOR receiver
GZH44_04045	COG0531	amino acid
GZH44_04060	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
GZH44_04075	COG4443	Transcriptional Coactivator p15 (PC4)
GZH44_04080	COG0252	asparaginase activity
GZH44_04090	COG1113	amino acid transport
GZH44_04100	COG0531	amino acid
GZH44_04110	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
GZH44_04115	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GZH44_04125	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
GZH44_04135	COG0477	Major facilitator Superfamily
GZH44_04140	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GZH44_04140	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
GZH44_04155	COG3716	PTS system mannose fructose sorbose family IID component
GZH44_04170	COG2188	Transcriptional regulator
GZH44_04175	COG2188	Transcriptional regulator
GZH44_04180	COG0531	amino acid
GZH44_04195	COG2855	membrane
GZH44_04200	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GZH44_04215	COG1012	belongs to the aldehyde dehydrogenase family
GZH44_04275	COG1113	amino acid transport
GZH44_04290	COG0628	permease
GZH44_04305	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GZH44_04310	COG0765	amino acid transport
GZH44_04315	COG1126	abc transporter atp-binding protein
GZH44_04325	COG0656	L-ascorbic acid biosynthetic process
GZH44_04335	COG0436	Aminotransferase
GZH44_04340	COG0277	FAD linked oxidase domain protein
GZH44_04345	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
GZH44_04350	COG1122	ATPase activity
GZH44_04355	COG4720	Psort location CytoplasmicMembrane, score
GZH44_04360	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GZH44_04365	COG2357	RelA SpoT domain protein
GZH44_04370	COG1744	ABC transporter substrate-binding protein PnrA-like
GZH44_04395	COG3048	D-serine ammonia-lyase activity
GZH44_04410	COG1136	(ABC) transporter
GZH44_04430	COG0789	Transcriptional regulator
GZH44_04435	COG0477	Major facilitator Superfamily
GZH44_04440	COG1827	regulation of RNA biosynthetic process
GZH44_04450	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GZH44_04470	COG0402	S-adenosylhomocysteine deaminase activity
GZH44_04475	COG1268	BioY protein
GZH44_04490	COG1070	Carbohydrate kinase
GZH44_04505	COG2211	Major facilitator Superfamily
GZH44_04505	COG2190	(PTS) system
GZH44_04540	COG1609	Transcriptional regulator
GZH44_04545	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
GZH44_04550	COG1881	PFAM PEBP family protein
GZH44_04555	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GZH44_04560	COG0436	Aminotransferase
GZH44_04565	COG0110	maltose O-acetyltransferase activity
GZH44_04570	COG0110	maltose O-acetyltransferase activity
GZH44_04575	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
GZH44_04585	COG0531	amino acid
GZH44_04610	COG2252	PERMEase
GZH44_04625	COG1131	(ABC) transporter
GZH44_04630	COG2186	Transcriptional regulator
GZH44_04635	COG0328	RNA-DNA hybrid ribonuclease activity
GZH44_04640	COG0561	phosphatase activity
GZH44_04645	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GZH44_04665	COG0028	Belongs to the TPP enzyme family
GZH44_04680	COG4221	oxidoreductase activity
GZH44_04685	COG0789	Transcriptional regulator
GZH44_04690	COG1301	dicarboxylic acid transport
GZH44_04695	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GZH44_04700	COG2022	thiamine diphosphate biosynthetic process
GZH44_04705	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GZH44_04725	COG1113	amino acid transport
GZH44_04730	COG0569	domain protein
GZH44_04735	COG5386	Cell surface protein
GZH44_04755	COG1120	ATPase activity
GZH44_04770	COG0706	membrane insertase activity
GZH44_04775	COG0594	ribonuclease P activity
GZH44_04780	COG0230	Belongs to the bacterial ribosomal protein bL34 family
GZH44_04785	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GZH44_04790	COG0592	DNA-directed DNA polymerase activity
GZH44_04795	COG2501	S4 domain
GZH44_04800	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GZH44_04805	COG0187	DNA topoisomerase II activity
GZH44_04820	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GZH44_04825	COG2011	ABC-type metal ion transport system permease component
GZH44_04830	COG1464	Belongs to the NlpA lipoprotein family
GZH44_04840	COG2409	Drug exporters of the RND superfamily
GZH44_04855	COG1368	sulfuric ester hydrolase activity
GZH44_04875	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
GZH44_04910	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GZH44_04910	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GZH44_04915	COG0025	NhaP-type Na H and K H
GZH44_04920	COG0084	hydrolase, TatD family'
GZH44_04925	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
GZH44_04930	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GZH44_04935	COG1253	flavin adenine dinucleotide binding
GZH44_04940	COG1253	flavin adenine dinucleotide binding
GZH44_04945	COG4466	Protein conserved in bacteria
GZH44_04950	COG2131	deaminase
GZH44_04960	COG1316	TRANSCRIPTIONal
GZH44_04990	COG0737	Belongs to the 5'-nucleotidase family
GZH44_05035	COG2814	Major facilitator Superfamily
GZH44_05045	COG1120	ATPase activity
GZH44_05060	COG0561	phosphatase activity
GZH44_05115	COG1511	domain protein
GZH44_05130	COG0193	aminoacyl-tRNA hydrolase activity
GZH44_05135	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
GZH44_05140	COG2244	polysaccharide biosynthetic process
GZH44_05145	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
GZH44_05170	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
GZH44_05175	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
GZH44_05505	COG1846	Transcriptional regulator
GZH44_05510	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GZH44_05515	COG0604	alcohol dehydrogenase
GZH44_05520	COG3759	membrane
GZH44_05530	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
GZH44_05555	COG0583	DNA-binding transcription factor activity
GZH44_05575	COG2261	transglycosylase associated protein
GZH44_05585	COG1737	Transcriptional regulator
GZH44_05590	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
GZH44_05600	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GZH44_05605	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GZH44_05615	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GZH44_05620	COG1956	GAF domain-containing protein
GZH44_05630	COG2814	Major facilitator Superfamily
GZH44_05635	COG2233	PERMEase
GZH44_05640	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GZH44_05645	COG2084	Dehydrogenase
GZH44_05650	COG0438	transferase activity, transferring glycosyl groups
GZH44_05715	COG1175	transmembrane transport
GZH44_05730	COG3250	beta-galactosidase activity
GZH44_05735	COG3842	ATPase activity
GZH44_05740	COG1250	3-hydroxyacyl-CoA dehydrogenase
GZH44_05745	COG0626	cystathionine gamma-synthase activity
GZH44_05750	COG1088	dTDP-glucose 4,6-dehydratase activity
GZH44_05755	COG4989	oxidoreductase activity
GZH44_05765	COG3764	Sortase (surface protein transpeptidase)
GZH44_05770	COG0702	epimerase
GZH44_05775	COG1733	regulation of RNA biosynthetic process
GZH44_05780	COG0693	protein deglycase activity
GZH44_05785	COG1609	Transcriptional regulator
GZH44_05790	COG1874	Beta-galactosidase
GZH44_05805	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
GZH44_05810	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
GZH44_05815	COG2376	Dihydroxyacetone kinase
GZH44_05820	COG1461	Dihydroxyacetone kinase
GZH44_05825	COG1737	Transcriptional regulator
GZH44_05830	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GZH44_05830	COG1263	PTS System
GZH44_05835	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
GZH44_05840	COG0028	Belongs to the TPP enzyme family
GZH44_05865	COG2514	catechol 2,3-dioxygenase activity
GZH44_05870	COG0386	Belongs to the glutathione peroxidase family
GZH44_05875	COG1063	alcohol dehydrogenase
GZH44_05880	COG0431	NADPH-dependent FMN reductase
GZH44_05885	COG2807	transmembrane transport
GZH44_05890	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GZH44_05920	COG0671	phosphoesterase, PA-phosphatase related
GZH44_05925	COG0495	leucyl-tRNA aminoacylation
GZH44_05935	COG2244	polysaccharide biosynthetic process
GZH44_05965	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
GZH44_05970	COG0531	amino acid
GZH44_05975	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GZH44_05980	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
GZH44_05985	COG1074	ATP-dependent DNA helicase activity
GZH44_05990	COG2814	Major facilitator Superfamily
GZH44_05995	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GZH44_06005	COG1051	belongs to the nudix hydrolase family
GZH44_06010	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GZH44_06020	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GZH44_06030	COG0360	Binds together with S18 to 16S ribosomal RNA
GZH44_06035	COG0629	single-stranded DNA binding
GZH44_06040	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
GZH44_06060	COG0516	GMP reductase activity
GZH44_06060	COG0517	IMP dehydrogenase activity
GZH44_06065	COG0517	IMP dehydrogenase activity
GZH44_06065	COG0516	GMP reductase activity
GZH44_06075	COG0745	RESPONSE REGULATOR receiver
GZH44_06080	COG5002	protein histidine kinase activity
GZH44_06095	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
GZH44_06100	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GZH44_06110	COG1078	dGTPase activity
GZH44_06115	COG0561	phosphatase activity
GZH44_06120	COG3343	RNA polymerase activity
GZH44_06125	COG0504	CTP synthase activity
GZH44_06130	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GZH44_06145	COG2337	Toxic component of a toxin-antitoxin (TA) module
GZH44_06165	COG0673	inositol 2-dehydrogenase activity
GZH44_06170	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GZH44_06180	COG0194	GDP metabolic process
GZH44_06200	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GZH44_06205	COG0765	amino acid transport
GZH44_06210	COG0765	amino acid transport
GZH44_06215	COG4166	transmembrane transport
GZH44_06220	COG0601	transmembrane transport
GZH44_06225	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GZH44_06230	COG0444	Belongs to the ABC transporter superfamily
GZH44_06235	COG4608	Belongs to the ABC transporter superfamily
GZH44_06245	COG0359	binds to the 23S rRNA
GZH44_06250	COG0305	Participates in initiation and elongation during chromosome replication
GZH44_06255	COG2814	Major facilitator Superfamily
GZH44_06260	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GZH44_06265	COG2832	Protein of unknown function (DUF454)
GZH44_06275	COG1744	ABC transporter substrate-binding protein PnrA-like
GZH44_06280	COG2814	Major facilitator Superfamily
GZH44_06290	COG0492	ferredoxin-NADP+ reductase activity
GZH44_06295	COG0588	phosphoglycerate mutase activity
GZH44_06350	COG1309	transcriptional regulator
GZH44_06360	COG1064	alcohol dehydrogenase
GZH44_06365	COG1609	Transcriptional regulator
GZH44_06385	COG1028	Short-chain dehydrogenase reductase Sdr
GZH44_06390	COG2610	gluconate transmembrane transporter activity
GZH44_06395	COG0628	permease
GZH44_06400	COG1744	ABC transporter substrate-binding protein PnrA-like
GZH44_06405	COG3845	ABC transporter
GZH44_06410	COG4603	Belongs to the binding-protein-dependent transport system permease family
GZH44_06415	COG1079	Belongs to the binding-protein-dependent transport system permease family
GZH44_06420	COG0561	phosphatase activity
GZH44_06425	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GZH44_06430	COG1077	Cell shape determining protein MreB Mrl
GZH44_06440	COG0772	Belongs to the SEDS family
GZH44_06445	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GZH44_06460	COG0561	phosphatase activity
GZH44_06465	COG0577	efflux transmembrane transporter activity
GZH44_06465	COG1136	(ABC) transporter
GZH44_06475	COG2188	Transcriptional regulator
GZH44_06480	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
GZH44_06485	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
GZH44_06500	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
GZH44_06510	COG0640	Transcriptional regulator
GZH44_06520	COG2246	polysaccharide biosynthetic process
GZH44_06525	COG0561	phosphatase activity
GZH44_06530	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GZH44_06535	COG4589	Belongs to the CDS family
GZH44_06540	COG0750	zinc metalloprotease
GZH44_06545	COG0442	prolyl-tRNA aminoacylation
GZH44_06550	COG2176	DNA-directed DNA polymerase activity
GZH44_06570	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GZH44_06605	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
GZH44_06615	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GZH44_06625	COG2183	response to ionizing radiation
GZH44_06655	COG2217	Heavy metal translocating P-type atpase
GZH44_06670	COG1136	(ABC) transporter
GZH44_06680	COG1940	carbohydrate kinase activity
GZH44_06730	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GZH44_06735	COG1045	serine acetyltransferase
GZH44_06740	COG0582	viral genome integration into host DNA
GZH44_06745	COG3759	membrane
GZH44_06750	COG1396	sequence-specific DNA binding
GZH44_06805	COG2261	transglycosylase associated protein
GZH44_06815	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
GZH44_06840	COG0516	GMP reductase activity
GZH44_06845	COG0668	transmembrane transport
GZH44_06860	COG0402	S-adenosylhomocysteine deaminase activity
GZH44_06865	COG0745	RESPONSE REGULATOR receiver
GZH44_06870	COG5002	protein histidine kinase activity
GZH44_06870	COG3850	Histidine kinase
GZH44_06875	COG2017	converts alpha-aldose to the beta-anomer
GZH44_06880	COG0166	Belongs to the GPI family
GZH44_06885	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GZH44_06900	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
GZH44_06905	COG0291	Belongs to the bacterial ribosomal protein bL35 family
GZH44_06915	COG0228	four-way junction DNA binding
GZH44_06920	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
GZH44_06925	COG0049	tRNA binding
GZH44_06930	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GZH44_06940	COG3842	ATPase activity
GZH44_06950	COG1177	transmembrane transport
GZH44_06970	COG0589	response to stress
GZH44_06985	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
GZH44_06990	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GZH44_06995	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GZH44_07000	COG0492	ferredoxin-NADP+ reductase activity
GZH44_07005	COG0406	alpha-ribazole phosphatase activity
GZH44_07010	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GZH44_07020	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GZH44_07030	COG0366	Alpha amylase catalytic
GZH44_07040	COG1175	transmembrane transport
GZH44_07045	COG3833	ABC-type maltose transport systems, permease component
GZH44_07050	COG3842	ATPase activity
GZH44_07060	COG0149	triose-phosphate isomerase activity
GZH44_07080	COG0557	exoribonuclease II activity
GZH44_07085	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
GZH44_07090	COG0765	amino acid transport
GZH44_07095	COG1126	abc transporter atp-binding protein
GZH44_07110	COG0280	phosphate acetyltransferase
GZH44_07120	COG0802	atpase or kinase
GZH44_07135	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GZH44_07140	COG0025	NhaP-type Na H and K H
GZH44_07150	COG4856	YbbR-like protein
GZH44_07155	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GZH44_07165	COG0438	transferase activity, transferring glycosyl groups
GZH44_07170	COG0438	transferase activity, transferring glycosyl groups
GZH44_07185	COG1368	sulfuric ester hydrolase activity
GZH44_07250	COG3715	PTS system
GZH44_07255	COG3716	PTS system mannose fructose sorbose family IID component
GZH44_07265	COG0588	phosphoglycerate mutase activity
GZH44_07300	COG0126	phosphoglycerate kinase activity
GZH44_07315	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
GZH44_07325	COG0517	IMP dehydrogenase activity
GZH44_07325	COG1125	glycine betaine transport
GZH44_07330	COG1174	glycine betaine transport
GZH44_07335	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GZH44_07370	COG1396	sequence-specific DNA binding
GZH44_07430	COG1396	sequence-specific DNA binding
GZH44_07455	COG0629	single-stranded DNA binding
GZH44_07505	COG5484	DNA packaging
GZH44_07625	COG1757	Na H antiporter
GZH44_07630	COG0328	RNA-DNA hybrid ribonuclease activity
GZH44_07640	COG0564	pseudouridine synthase activity
GZH44_07645	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
GZH44_07650	COG0505	Belongs to the CarA family
GZH44_07660	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GZH44_07665	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GZH44_07710	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
GZH44_07715	COG2267	carboxylic ester hydrolase activity
GZH44_07725	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GZH44_07730	COG1846	Transcriptional regulator
GZH44_07735	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GZH44_07740	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GZH44_07745	COG2070	2-Nitropropane dioxygenase
GZH44_07755	COG1028	Short-chain dehydrogenase reductase Sdr
GZH44_07760	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GZH44_07775	COG0439	Biotin carboxylase
GZH44_07790	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GZH44_07795	COG1704	LemA family
GZH44_07800	COG0501	Belongs to the peptidase M48B family
GZH44_07805	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GZH44_07810	COG1335	isochorismatase
GZH44_07815	COG0673	inositol 2-dehydrogenase activity
GZH44_07820	COG0513	Belongs to the DEAD box helicase family
GZH44_07825	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
GZH44_07830	COG1321	iron dependent repressor
GZH44_07830	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GZH44_07855	COG0527	aspartate kinase activity
GZH44_07860	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GZH44_07865	COG0019	diaminopimelate decarboxylase activity
GZH44_07870	COG2171	N-acyltransferase activity
GZH44_07875	COG1473	amidohydrolase
GZH44_07880	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GZH44_07890	COG0436	Aminotransferase
GZH44_07895	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GZH44_07905	COG0436	Aminotransferase
GZH44_07910	COG4684	Psort location CytoplasmicMembrane, score
GZH44_07925	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GZH44_07930	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
GZH44_07935	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GZH44_07940	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
GZH44_07945	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
GZH44_07950	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GZH44_07955	COG0710	3-dehydroquinate dehydratase activity
GZH44_07970	COG1122	ATPase activity
GZH44_07975	COG4721	ABC-type cobalt transport system, permease component
GZH44_07980	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GZH44_07985	COG0667	Aldo Keto reductase
GZH44_07990	COG4807	Protein conserved in bacteria
GZH44_07995	COG1914	H( )-stimulated, divalent metal cation uptake system
GZH44_08015	COG2936	dipeptidyl-peptidase activity
GZH44_08020	COG0561	phosphatase activity
GZH44_08025	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GZH44_08030	COG0154	amidase activity
GZH44_08035	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GZH44_08040	COG1597	lipid kinase activity
GZH44_08065	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
GZH44_08090	COG0285	dihydrofolate synthase activity
GZH44_08095	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
GZH44_08110	COG0018	arginyl-trna synthetase
GZH44_08115	COG1438	arginine binding
GZH44_08120	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GZH44_08125	COG3679	Belongs to the UPF0342 family
GZH44_08135	COG4717	serine-type aminopeptidase activity
GZH44_08140	COG3481	metal-dependent phosphohydrolase, HD sub domain
GZH44_08145	COG1070	Carbohydrate kinase
GZH44_08150	COG3402	PFAM membrane-flanked domain
GZH44_08170	COG2610	gluconate transmembrane transporter activity
GZH44_08180	COG0612	Peptidase, M16
GZH44_08185	COG1426	Protein conserved in bacteria
GZH44_08190	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GZH44_08195	COG1546	Belongs to the CinA family
GZH44_08195	COG1058	Belongs to the CinA family
GZH44_08200	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
GZH44_08205	COG3973	AAA domain
GZH44_08215	COG1388	LysM domain
GZH44_08220	COG2814	Major facilitator Superfamily
GZH44_08230	COG1278	Cold shock
GZH44_08235	COG0564	pseudouridine synthase activity
GZH44_08245	COG2309	aminopeptidase activity
GZH44_08270	COG0393	Putative heavy-metal-binding
GZH44_08275	COG3475	LICD family
GZH44_08285	COG1134	teichoic acid transport
GZH44_08285	COG1388	LysM domain
GZH44_08290	COG1682	transport, permease protein
GZH44_08305	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
GZH44_08305	COG0463	Glycosyl transferase, family 2
GZH44_08310	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
GZH44_08340	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
GZH44_08345	COG1215	transferase activity, transferring glycosyl groups
GZH44_08345	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
GZH44_08375	COG1501	Belongs to the glycosyl hydrolase 31 family
GZH44_08395	COG0366	Alpha amylase catalytic
GZH44_08395	COG5263	repeat protein
GZH44_08400	COG0024	Methionine aminopeptidase
GZH44_08425	COG0562	UDP-galactopyranose mutase
GZH44_08440	COG0463	Glycosyl transferase, family 2
GZH44_08445	COG1216	Glycosyl transferase, family 2
GZH44_08465	COG1420	regulation of RNA biosynthetic process
GZH44_08475	COG0443	Heat shock 70 kDa protein
GZH44_08480	COG0484	heat shock protein binding
GZH44_08495	COG1234	tRNA 3'-trailer cleavage
GZH44_08500	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GZH44_08500	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
GZH44_08505	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GZH44_08525	COG1368	sulfuric ester hydrolase activity
GZH44_08550	COG0110	maltose O-acetyltransferase activity
GZH44_08555	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GZH44_08560	COG4224	UPF0291 protein
GZH44_08565	COG3763	UPF0154 protein
GZH44_08570	COG0204	Acyl-transferase
GZH44_08575	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
GZH44_08580	COG2827	Endonuclease containing a URI domain
GZH44_08585	COG0052	Belongs to the universal ribosomal protein uS2 family
GZH44_08590	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
GZH44_08610	COG0004	ammonium transporteR
GZH44_08615	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GZH44_08625	COG0617	tRNA 3'-terminal CCA addition
GZH44_08630	COG0488	(ABC) transporter
GZH44_08645	COG0587	DNA-directed DNA polymerase activity
GZH44_08650	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GZH44_08655	COG1490	D-aminoacyl-tRNA deacylase activity
GZH44_08665	COG0475	glutathione-regulated potassium exporter activity
GZH44_08675	COG2996	Protein conserved in bacteria
GZH44_08690	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
GZH44_08695	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
GZH44_08700	COG1187	pseudouridine synthase activity
GZH44_08705	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
GZH44_08715	COG0514	ATP-dependent DNA helicase (RecQ)
GZH44_08725	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GZH44_08730	COG0539	negative regulation of cytoplasmic translation
GZH44_08735	COG1160	GTP binding
GZH44_08745	COG0351	phosphomethylpyrimidine kinase
GZH44_08750	COG4720	Psort location CytoplasmicMembrane, score
GZH44_08755	COG2807	transmembrane transport
GZH44_08760	COG0420	3'-5' exonuclease activity
GZH44_08765	COG0419	ATPase involved in DNA repair
GZH44_08785	COG0457	Tetratricopeptide repeat
GZH44_08790	COG2384	SAM-dependent methyltransferase
GZH44_08795	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
GZH44_08800	COG2195	Cleaves the N-terminal amino acid of tripeptides
GZH44_08810	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
GZH44_08820	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GZH44_08825	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GZH44_08830	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GZH44_08870	COG2169	Transcriptional regulator
GZH44_08875	COG2190	(PTS) system
GZH44_08875	COG2211	Major facilitator Superfamily
GZH44_08885	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
GZH44_08895	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GZH44_08900	COG4708	membrane
GZH44_08905	COG0481	GTPase activity
GZH44_08935	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GZH44_08940	COG0277	FAD linked oxidase domain protein
GZH44_08975	COG0588	phosphoglycerate mutase activity
GZH44_08980	COG1464	Belongs to the NlpA lipoprotein family
GZH44_08990	COG0071	Belongs to the small heat shock protein (HSP20) family
GZH44_08995	COG0561	phosphatase activity
GZH44_09010	COG3022	response to hydroperoxide
GZH44_09015	COG0406	alpha-ribazole phosphatase activity
GZH44_09035	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GZH44_09045	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
GZH44_09055	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GZH44_09060	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GZH44_09065	COG0047	phosphoribosylformylglycinamidine synthase activity
GZH44_09070	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GZH44_09085	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
GZH44_09090	COG0138	bifunctional purine biosynthesis protein purh
GZH44_09095	COG0151	Belongs to the GarS family
GZH44_09125	COG1609	Transcriptional regulator
GZH44_09135	COG0366	Alpha amylase catalytic
GZH44_09145	COG2223	nitrite transmembrane transporter activity
GZH44_09155	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
GZH44_09160	COG0351	phosphomethylpyrimidine kinase
GZH44_09175	COG1397	ADP-ribosylglycohydrolase
GZH44_09180	COG1719	4-vinyl reductase, 4VR
GZH44_09185	COG0220	tRNA (guanine-N7-)-methyltransferase activity
GZH44_09195	COG1131	(ABC) transporter
GZH44_09200	COG0537	adenosine 5'-monophosphoramidase activity
GZH44_09210	COG0556	nucleotide-excision repair
GZH44_09225	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GZH44_09235	COG0116	Belongs to the methyltransferase superfamily
GZH44_09245	COG3599	regulation of cell shape
GZH44_09250	COG4474	Belongs to the UPF0398 family
GZH44_09255	COG3331	DNA recombination
GZH44_09265	COG3935	DnaD domain protein
GZH44_09270	COG0017	Asparaginyl-tRNA synthetase
GZH44_09280	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GZH44_09280	COG1199	ATP-dependent helicase activity
GZH44_09285	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
GZH44_09300	COG1304	FMN binding
GZH44_09310	COG0706	membrane insertase activity
GZH44_09320	COG5002	protein histidine kinase activity
GZH44_09325	COG0745	RESPONSE REGULATOR receiver
GZH44_09340	COG1484	DNA-dependent DNA replication
GZH44_09350	COG0237	dephospho-CoA kinase activity
GZH44_09355	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GZH44_09380	COG0693	protein deglycase activity
GZH44_09395	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
GZH44_09400	COG1733	regulation of RNA biosynthetic process
GZH44_09405	COG0702	epimerase
GZH44_09435	COG0783	Belongs to the Dps family
GZH44_09440	COG1250	3-hydroxyacyl-CoA dehydrogenase
GZH44_09455	COG2274	protein secretion by the type I secretion system
GZH44_09455	COG3271	cysteine-type peptidase activity
GZH44_09465	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
GZH44_09500	COG0668	transmembrane transport
GZH44_09540	COG2801	Transposase and inactivated derivatives
GZH44_09565	COG4619	ABC transporter
GZH44_09570	COG0390	transport system, permease component
GZH44_09590	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GZH44_09595	COG0783	Belongs to the Dps family
GZH44_09620	COG0604	alcohol dehydrogenase