locus-tag	class	description
FOL01_0001	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
FOL01_0002	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
FOL01_0003	ENOG410848D	S4 domain protein YaaA
FOL01_0004	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
FOL01_0005	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
FOL01_0007	ENOG4105DZW	Dipeptidase
FOL01_0009	ENOG4105CHR	reductase
FOL01_0010	ENOG4108JEI	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity)
FOL01_0011	ENOG4108UMI	ABC transporter, permease
FOL01_0014	ENOG4105EYF	MMPL domain protein
FOL01_0018	ENOG4105E0M	Sulfatase
FOL01_0022	ENOG4105NDF	NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity)
FOL01_0023	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
FOL01_0024	ENOG4107SUZ	Sodium/hydrogen exchanger family
FOL01_0026	ENOG4105F8V	Hydrolase, tatD family
FOL01_0027	ENOG4105HVR	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity)
FOL01_0028	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
FOL01_0029	ENOG4105C37	(CBS) domain
FOL01_0030	ENOG4105C37	(CBS) domain
FOL01_0032	ENOG4108UK2	deaminase
FOL01_0033	ENOG4105C0V	Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity)
FOL01_0034	ENOG4108KGH	TRANSCRIPTIONal
FOL01_0036	ENOG4105D5T	phosphonate abc transporter
FOL01_0039	ENOG4107RNS	bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic
FOL01_0043	ENOG4105CHR	reductase
FOL01_0049	ENOG4105HUF	DNA protection during starvation protein
FOL01_0052	ENOG4108UQV	Membrane
FOL01_0053	ENOG41067S9	phage shock protein C, PspC
FOL01_0057	ENOG4108R3E	Dna-3-methyladenine glycosylase i
FOL01_0059	ENOG4105EY8	ABC transporter
FOL01_0060	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
FOL01_0063	ENOG4108ZQX	ybak prolyl-trna synthetase
FOL01_0065	ENOG4108JQ7	(ABC) transporter
FOL01_0066	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
FOL01_0067	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
FOL01_0070	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
FOL01_0071	ENOG410630P	Transcriptional regulator
FOL01_0074	ENOG4105EC0	Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity)
FOL01_0075	ENOG4105UBK	short-chain dehydrogenase reductase
FOL01_0078	ENOG4105CIG	ABC transporter
FOL01_0079	ENOG4105CIG	ABC transporter
FOL01_0081	ENOG4105CM2	brancheD-chain amino acid aminotransferase
FOL01_0082	ENOG4108JZF	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity)
FOL01_0083	ENOG4108URH	decarboxylase
FOL01_0084	ENOG4105EC0	Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity)
FOL01_0086	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
FOL01_0088	ENOG4107TCE	N-acetyltransferase
FOL01_0090	ENOG4105ETE	Transcriptional regulator (LacI family
FOL01_0091	ENOG4108UIN	ybak prolyl-trna synthetase associated region
FOL01_0095	ENOG4105F8V	Hydrolase, tatD family
FOL01_0097	ENOG4105ST3	Transcriptional regulator
FOL01_0098	ENOG4105ECB	domain protein
FOL01_0099	ENOG4105CH6	catalase
FOL01_0100	ENOG4105DU1	integral membrane protein, terc
FOL01_0103	ENOG4108ZPD	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity)
FOL01_0104	ENOG4108JA2	transcriptioN-repair coupling factor
FOL01_0106	ENOG41082I2	s4 domain protein
FOL01_0111	ENOG4105F4C	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity)
FOL01_0112	ENOG4105CRK	lysyL-tRNA synthetase
FOL01_0151	ENOG4105K5M	30s ribosomal protein S16
FOL01_0168	ENOG4108X9F	tail fiber protein
FOL01_0173	ENOG4105K56	Transcriptional regulator
FOL01_0174	ENOG4107QN2	dihydrolipoyl dehydrogenase
FOL01_0175	ENOG4105CIS	alcohol dehydrogenase
FOL01_0176	ENOG4105KA3	membrAne
FOL01_0178	ENOG4105CUU	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity)
FOL01_0182	ENOG4107BMA	Transglycosylase associated protein
FOL01_0184	ENOG4106KNT	transcriptional regulator
FOL01_0188	ENOG4105D82	Glutamate dehydrogenase
FOL01_0192	ENOG4105DC8	reductase
FOL01_0193	ENOG4105F27	Major Facilitator
FOL01_0195	ENOG4108UPS	Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity)
FOL01_0196	ENOG4105CF3	3-Hydroxyisobutyrate dehydrogenase
FOL01_0203	ENOG4105CV8	reductase
FOL01_0206	ENOG4105CR4	methylisocitrate lyase
FOL01_0208	ENOG4105C28	cystathionine
FOL01_0209	ENOG4105F35	Catalyzes the NAD( )-dependent oxidation of L-carnitine to 3-dehydrocarnitine (By similarity)
FOL01_0210	ENOG4105C1B	dTDP-glucose 4-6-dehydratase
FOL01_0211	ENOG4107RGM	aldo keto reductase
FOL01_0213	ENOG4108Z0Z	intracellular protease Pfpi family
FOL01_0214	ENOG4108HMR	Key enzyme in the regulation of glycerol uptake and metabolism (By similarity)
FOL01_0215	ENOG4105C6V	Glycerol-3-phosphate dehydrogenase
FOL01_0216	ENOG4105CP7	Triose-phosphate isomerase
FOL01_0217	ENOG4105D8C	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity)
FOL01_0220	ENOG4107RBJ	symporter
FOL01_0221	ENOG4105KVH	Transcriptional regulator
FOL01_0222	ENOG4108Z0Z	intracellular protease Pfpi family
FOL01_0223	ENOG4105C26	Dehydrogenase
FOL01_0228	ENOG4105EG2	ABC transporter, permease
FOL01_0234	ENOG4108IJ9	(ABC) transporter
FOL01_0239	ENOG4106G6Q	Transcriptional regulator
FOL01_0240	ENOG4105C5Y	PTS System
FOL01_0241	ENOG4105E15	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
FOL01_0242	ENOG4105C7K	acetolactate synthase
FOL01_0247	ENOG4108TKW	Glyoxalase Bleomycin resistance protein (Dioxygenase
FOL01_0248	ENOG4108V06	Glutathione peroxidase
FOL01_0250	ENOG4108YYH	Nadph-dependent fmn reductase
FOL01_0251	ENOG4105DJ2	Major Facilitator Superfamily
FOL01_0253	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
FOL01_0255	ENOG410841Q	phosphoesterase PA-phosphatase related protein
FOL01_0256	ENOG4105C8T	Leucyl-tRNA synthetase
FOL01_0259	ENOG41090I5	UPF0735 ACT domain-containing protein
FOL01_0261	ENOG4105D98	threonine synthase
FOL01_0262	ENOG4105D6E	homoserine dehydrogenase
FOL01_0266	ENOG4105C7Q	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity)
FOL01_0267	ENOG4107R7I	amino acid
FOL01_0268	ENOG4107QSE	Dipeptidase
FOL01_0269	ENOG4105C5N	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
FOL01_0270	ENOG4107R2I	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation
FOL01_0271	ENOG410605W	Major Facilitator
FOL01_0272	ENOG4108HMR	Key enzyme in the regulation of glycerol uptake and metabolism (By similarity)
FOL01_0274	ENOG4108Z4K	mutator MutT protein
FOL01_0275	ENOG4105DFT	pur operon repressor
FOL01_0277	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
FOL01_0278	ENOG4105DU0	nucleoside hydrolase
FOL01_0279	ENOG4108ZDX	Binds together with S18 to 16S ribosomal RNA (By similarity)
FOL01_0280	ENOG4108UUM	single-stranded DNA-binding protein
FOL01_0283	ENOG4108UM6	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity)
FOL01_0284	ENOG4105CY8	phosphoribosylaminoimidazole carboxylase atpase subunit
FOL01_0285	ENOG4105C8V	SAICAR synthetase
FOL01_0286	ENOG4105VR9	phosphoribosylformylglycinamidine synthase
FOL01_0287	ENOG4105D21	Phosphoribosylformylglycinamidine synthase I
FOL01_0288	ENOG4108JIU	phosphoribosylformylglycinamidine synthase ii
FOL01_0290	ENOG4105CXB	phosphoribosylaminoimidazole synthetase
FOL01_0291	ENOG4108V3E	phosphoribosylglycinamide formyltransferase
FOL01_0292	ENOG4105DC1	bifunctional purine biosynthesis protein purh
FOL01_0293	ENOG4105C12	Phosphoribosylglycinamide synthetase
FOL01_0294	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
FOL01_0295	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
FOL01_0296	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
FOL01_0297	ENOG4105BZU	Histidine kinase
FOL01_0300	ENOG4105Q2H	domain protein
FOL01_0301	ENOG4105C0H	protease
FOL01_0303	ENOG4105DCI	Phosphohydrolase
FOL01_0305	ENOG4108Z1Y	Participates in both the initiation and recycling phases of transcription. In the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling (By similarity)
FOL01_0306	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
FOL01_0307	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
FOL01_0308	ENOG4105C1J	atp-dependent rna helicase
FOL01_0309	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
FOL01_0310	ENOG4108YZM	Toxic component of a toxin-antitoxin (TA) module (By similarity)
FOL01_0311	ENOG4105EEM	helicase
FOL01_0312	ENOG4105C31	Tryptophanyl-tRNA synthetase
FOL01_0314	ENOG4105D9R	oxidoreductase
FOL01_0315	ENOG4105DR1	Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity)
FOL01_0317	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
FOL01_0320	ENOG4105CDA	abc transporter atp-binding protein
FOL01_0321	ENOG4105CT1	(ABC) transporter
FOL01_0322	ENOG4105EAD	ABC transporter
FOL01_0323	ENOG4105DRP	amino acid AbC transporter
FOL01_0324	ENOG4108J59	Extracellular solute-binding protein, family 5
FOL01_0325	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
FOL01_0326	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
FOL01_0328	ENOG4108JQ7	(ABC) transporter
FOL01_0330	ENOG4105K9Q	Binds to the 23S rRNA (By similarity)
FOL01_0331	ENOG4105CDU	Replicative dna helicase
FOL01_0333	ENOG4105CTR	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity)
FOL01_0334	ENOG4105DIH	basic membrane
FOL01_0337	ENOG4105CAY	ferredoxin--nadp reductase
FOL01_0338	ENOG4105DKJ	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
FOL01_0341	ENOG4105C6Z	Gluconate
FOL01_0343	ENOG4105CDH	Citrulline--aspartate ligase
FOL01_0344	ENOG4105CH7	arginosuccinase
FOL01_0354	ENOG4106F5Q	Membrane
FOL01_0355	ENOG4105DIH	basic membrane
FOL01_0356	ENOG4105DIH	basic membrane
FOL01_0357	ENOG4108JQ9	ABC transporter
FOL01_0358	ENOG4105UIB	(ABC) transporter
FOL01_0360	ENOG410667J	hydrolase
FOL01_0361	ENOG4107EES	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity)
FOL01_0362	ENOG4105DFF	Rod shape-determining protein mreb
FOL01_0369	ENOG4105DQF	Hydrolase
FOL01_0370	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
FOL01_0371	ENOG4105CE4	GlcNAc 6-P deacetylase
FOL01_0372	ENOG4105FDP	GntR family transcriptional regulator
FOL01_0373	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
FOL01_0374	ENOG4105DGY	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization (By similarity)
FOL01_0376	ENOG4105C91	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
FOL01_0377	ENOG4108UGV	hypoxanthine phosphoribosyltransferase
FOL01_0378	ENOG4105PGM	cation diffusion facilitator family transporter
FOL01_0381	ENOG4105WH5	Teichoic acid glycosylation protein
FOL01_0382	ENOG4108HCJ	Hydrolase
FOL01_0383	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
FOL01_0384	ENOG4105KNE	Phosphatidate cytidylyltransferase
FOL01_0385	ENOG4105DZP	Membrane-associated zinc metalloprotease
FOL01_0386	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
FOL01_0387	ENOG4105DE5	Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity)
FOL01_0388	ENOG4105EWI	Short-chain dehydrogenase reductase Sdr
FOL01_0389	ENOG4105C2N	RNA methyltransferase TrmH family group 3
FOL01_0393	ENOG4105MS2	ribosomal subunit Interface protein
FOL01_0396	ENOG4105J7I	hydrolase
FOL01_0399	ENOG4105E4Y	Endoribonuclease that initiates mRNA decay (By similarity)
FOL01_0401	ENOG4105C19	ABC transporter
FOL01_0403	ENOG4105EVU	fructokinase
FOL01_0405	ENOG4105DWR	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity)
FOL01_0406	ENOG4108MR7	Arylsulfotransferase
FOL01_0412	ENOG4108UW5	maltose o-acetyltransferase
FOL01_0418	ENOG4105VTR	Integrase
FOL01_0420	ENOG4105KWG	Pfam:DUF1696
FOL01_0422	ENOG4105M7P	phage repressor
FOL01_0433	ENOG4108UUM	single-stranded DNA-binding protein
FOL01_0448	ENOG4108ES9	ParB domain protein nuclease
FOL01_0476	ENOG4107SJ1	Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity)
FOL01_0477	ENOG4105D64	Mechanosensitive ion channel
FOL01_0480	ENOG4105DZC	cytosine deaminase
FOL01_0481	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
FOL01_0482	ENOG4105BZU	Histidine kinase
FOL01_0483	ENOG4105CSC	Glucose uptake protein
FOL01_0484	ENOG4105CSC	Glucose uptake protein
FOL01_0485	ENOG4105ENN	converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity)
FOL01_0486	ENOG4107QYV	phosphohexose isomerase
FOL01_0487	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
FOL01_0489	ENOG4105M7K	Involved in the transcription termination process (By similarity)
FOL01_0490	ENOG4108UUX	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity)
FOL01_0491	ENOG4105VJV	50s ribosomal protein L35
FOL01_0492	ENOG4108YZX	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity)
FOL01_0494	ENOG4108UKE	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity)
FOL01_0495	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
FOL01_0496	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
FOL01_0497	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
FOL01_0498	ENOG4105F38	ABC transporter, permease
FOL01_0499	ENOG4105D38	putrescine abc transporter
FOL01_0500	ENOG4107RUE	extracellular solute-binding protein family 1
FOL01_0501	ENOG4108R5K	PPIases accelerate the folding of proteins (By similarity)
FOL01_0503	ENOG4105DQ6	Transposase
FOL01_0507	ENOG41086DT	Membrane protein of unknown function
FOL01_0508	ENOG4105D1C	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity)
FOL01_0510	ENOG4105C3Y	UTP-glucose-1-phosphate uridylyltransferase
FOL01_0511	ENOG4105C3M	thioredoxin reductase
FOL01_0512	ENOG4105CVJ	phosphoglycerate mutase
FOL01_0513	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
FOL01_0515	ENOG4105KRI	phosphocarrier protein (HPr
FOL01_0516	ENOG4105BZ3	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity)
FOL01_0517	ENOG4105CG3	alpha amylase, catalytic region
FOL01_0518	ENOG4105CP7	Triose-phosphate isomerase
FOL01_0520	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
FOL01_0522	ENOG4105C40	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity)
FOL01_0523	ENOG4108UH4	Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity)
FOL01_0524	ENOG4105E5Q	amino acid AbC transporter
FOL01_0525	ENOG4105CDA	abc transporter atp-binding protein
FOL01_0528	ENOG4108IJ2	phosphate acetyltransferase
FOL01_0530	ENOG4105K8N	protein family UPF0079, ATPase
FOL01_0532	ENOG4105DE5	Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity)
FOL01_0533	ENOG4105D4A	Cell wall formation (By similarity)
FOL01_0534	ENOG4105EEQ	Na H antiporter
FOL01_0536	ENOG4107U5W	ybbr family
FOL01_0537	ENOG4107QJF	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity)
FOL01_0539	ENOG4105BZF	Glycosyl transferase (Group 1
FOL01_0540	ENOG4105W2C	Glycosyl transferase
FOL01_0543	ENOG4105E0M	Sulfatase
FOL01_0547	ENOG4105ETZ	PTS System
FOL01_0548	ENOG4105F3R	pts system mannose fructose sorbose family iid
FOL01_0551	ENOG4105ZT7	DNA-entry nuclease
FOL01_0556	ENOG4105MRB	Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity)
FOL01_0557	ENOG4105EV1	Ribose uptake protein RbsU
FOL01_0561	ENOG4105D01	(LipO)protein
FOL01_0563	ENOG4105CH2	amidohydrolase
FOL01_0564	ENOG4105C5I	Dehydrogenase
FOL01_0566	ENOG4105EAB	amino acid AbC transporter
FOL01_0567	ENOG4108HW4	amino acid AbC transporter
FOL01_0573	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
FOL01_0574	ENOG4105BZA	Phosphoglycerate kinase
FOL01_0577	ENOG4105C4U	4-methyl-5-beta-hydroxyethylthiazole kinase
FOL01_0578	ENOG4108UV6	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity)
FOL01_0579	ENOG4108IJ8	ABC transporter
FOL01_0580	ENOG4105E90	ABC transporter
FOL01_0581	ENOG4105CQX	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity)
FOL01_0583	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
FOL01_0586	ENOG4105DFD	Na H antiporter
FOL01_0587	ENOG4105VND	Ribonuclease
FOL01_0589	ENOG4105C34	Pseudouridine synthase
FOL01_0590	ENOG4108UK1	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity)
FOL01_0591	ENOG4105C1M	carbamoyl-phosphate synthetase glutamine chain
FOL01_0592	ENOG4105CU6	carbamoyl-phosphate synthetase ammonia chain
FOL01_0593	ENOG4107UUG	Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity)
FOL01_0594	ENOG4105C83	adenylosuccinate lyase
FOL01_0596	ENOG4108YXN	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity)
FOL01_0598	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
FOL01_0599	ENOG410854A	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
FOL01_0602	ENOG4105CHR	reductase
FOL01_0603	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
FOL01_0605	ENOG4108YXN	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity)
FOL01_0606	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
FOL01_0607	ENOG4107QTG	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity)
FOL01_0609	ENOG4105E66	phosphoriboisomerase A
FOL01_0611	ENOG4108V0P	LemA family
FOL01_0614	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
FOL01_0615	ENOG4105EE0	oxidoreductase
FOL01_0616	ENOG4105FDU	atp-dependent rna helicase
FOL01_0617	ENOG4105FF6	Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity)
FOL01_0618	ENOG4107RPQ	ABC transporter
FOL01_0620	ENOG4105X71	Membrane
FOL01_0621	ENOG4105ETE	Transcriptional regulator (LacI family
FOL01_0624	ENOG4105CFH	Aspartokinase
FOL01_0625	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
FOL01_0627	ENOG4105DMJ	Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity)
FOL01_0629	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
FOL01_0630	ENOG4105DUK	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity)
FOL01_0631	ENOG4105CHM	Aminotransferase
FOL01_0632	ENOG4105CM3	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity)
FOL01_0634	ENOG4105CHM	Aminotransferase
FOL01_0638	ENOG4105E2X	shikimate dehydrogenase
FOL01_0639	ENOG4108JPM	phospho-2-dehydro-3-deoxyheptonate aldolase
FOL01_0640	ENOG4105D49	3-dehydroquinate synthase
FOL01_0641	ENOG4105D10	5-enolpyruvylshikimate-3-phosphate phospholyase
FOL01_0642	ENOG4105CMY	5-enolpyruvylshikimate-3-phosphate synthase
FOL01_0643	ENOG4105KHV	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity)
FOL01_0644	ENOG4105FF2	Type I DHQase
FOL01_0646	ENOG4108J59	Extracellular solute-binding protein, family 5
FOL01_0647	ENOG4105CI2	imidazolone-5-propionate hydrolase
FOL01_0649	ENOG4108JJB	ABC transporter
FOL01_0650	ENOG4105NSK	ABC superfamily ATP binding cassette transporter membrane protein
FOL01_0651	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
FOL01_0652	ENOG4105CPC	Aldo Keto reductase
FOL01_0655	ENOG4105C56	H( )-stimulated, divalent metal cation uptake system (By similarity)
FOL01_0662	ENOG4105GYP	Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity)
FOL01_0663	ENOG4108KP7	hydrolase
FOL01_0664	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
FOL01_0665	ENOG4105VB5	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
FOL01_0666	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
FOL01_0667	ENOG4105CHT	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
FOL01_0668	ENOG4105CBD	Diacylglycerol kinase
FOL01_0669	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
FOL01_0671	ENOG4107EEN	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity)
FOL01_0673	ENOG4105C75	arginyL-tRNA synthetase
FOL01_0674	ENOG4105XBY	Regulates arginine biosynthesis genes (By similarity)
FOL01_0675	ENOG4105BZ4	penicillin-binding protein
FOL01_0676	ENOG4105WZB	UPF0342 protein
FOL01_0677	ENOG4107VRP	DNA repair exonuclease
FOL01_0678	ENOG4106D4I	domain protein
FOL01_0680	ENOG4105CMG	Carbohydrate kinase
FOL01_0684	ENOG4105BZU	Histidine kinase
FOL01_0685	ENOG410905X	membrane-flanked domain protein
FOL01_0686	ENOG4105CKV	Membrane
FOL01_0687	ENOG4108V0P	LemA family
FOL01_0690	ENOG4105DQ6	Transposase
FOL01_0695	ENOG4105BZQ	cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase
FOL01_0696	ENOG4105CEV	competence damage-inducible protein
FOL01_0697	ENOG4105C68	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)
FOL01_0698	ENOG4105EEM	helicase
FOL01_0699	ENOG4105CS9	pantothenic acid kinase
FOL01_0703	ENOG4105VEQ	Cold shock protein
FOL01_0704	ENOG4108YBP	pseudouridine synthase
FOL01_0706	ENOG4105C88	aminopeptidase
FOL01_0708	ENOG4108HW8	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity)
FOL01_0709	ENOG4105E0X	reductase
FOL01_0712	ENOG4108115	UPF0145 protein
FOL01_0713	ENOG4105KPE	licD family
FOL01_0715	ENOG4105EY8	ABC transporter
FOL01_0719	ENOG4107SJB	teichoic acid biosynthesis
FOL01_0720	ENOG4107ZIC	Glycerol-3-phosphate cytidylyltransferase
FOL01_0725	ENOG4107RZX	Teichoic acid biosynthesis protein
FOL01_0726	ENOG4107VDP	teichoic acid biosynthesis
FOL01_0732	ENOG4107UWA	esterase
FOL01_0733	ENOG4108M60	Transcriptional regulator
FOL01_0736	ENOG4105D7K	pfkb domain protein
FOL01_0737	ENOG4108VA3	3-hexulose-6-phosphate synthase
FOL01_0738	ENOG41080HJ	6-phospho 3-hexuloisomerase
FOL01_0748	ENOG4105CA1	Removes the N-terminal methionine from nascent proteins (By similarity)
FOL01_0749	ENOG4105D3Q	Sugar transferase
FOL01_0753	ENOG4105D5D	udp-galactopyranose mutase
FOL01_0756	ENOG4105CKK	Glycosyl transferase, family 2
FOL01_0757	ENOG4108RJ9	Glycosyl transferase, family 2
FOL01_0762	ENOG4105CI8	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity)
FOL01_0763	ENOG4105K90	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
FOL01_0764	ENOG4105CFG	Acts as a chaperone (By similarity)
FOL01_0765	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
FOL01_0769	ENOG4105C2R	Single-stranded-DNA-specific exonuclease (RecJ)
FOL01_0770	ENOG4109003	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity)
FOL01_0775	ENOG4105KT7	mgtC SapB transporter
FOL01_0776	ENOG4105DS7	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity)
FOL01_0777	ENOG4105VPS	UPF0291 protein
FOL01_0778	ENOG4105VXM	UPF0154 protein
FOL01_0779	ENOG4105F6E	Acyl-transferase
FOL01_0780	ENOG41060K3	Methyltransferase
FOL01_0781	ENOG4105VC4	domain protein
FOL01_0782	ENOG4105CE9	30S ribosomal protein S2
FOL01_0783	ENOG4105CU7	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity)
FOL01_0784	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
FOL01_0786	ENOG4108KGH	TRANSCRIPTIONal
FOL01_0787	ENOG4105BZU	Histidine kinase
FOL01_0788	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
FOL01_0790	ENOG4105D4J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
FOL01_0791	ENOG4105C5H	ABC transporter
FOL01_0794	ENOG4105C0B	DNA polymerase III (alpha subunit)
FOL01_0795	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
FOL01_0796	ENOG4108YYA	Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity)
FOL01_0798	ENOG4107RWR	Sodium hydrogen exchanger
FOL01_0800	ENOG4105QNR	S1 RNA binding domain protein
FOL01_0803	ENOG4108KVX	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity)
FOL01_0804	ENOG4105K8I	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity)
FOL01_0805	ENOG4105FE9	pseudouridine synthase
FOL01_0806	ENOG4108SAX	Membrane
FOL01_0808	ENOG4105C9U	ATP-dependent DNA helicase RecQ
FOL01_0810	ENOG4105CAT	Cytidine monophosphate kinase
FOL01_0811	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
FOL01_0812	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
FOL01_0813	ENOG4105K70	DNA-binding protein
FOL01_0814	ENOG4105DWF	phosphomethylpyrimidine kinase
FOL01_0815	ENOG4105PUK	Membrane
FOL01_0816	ENOG4107RH8	nuclease SbcCD subunit D
FOL01_0817	ENOG4105EYH	Exonuclease
FOL01_0820	ENOG41068YB	TPR repeat-containing protein
FOL01_0822	ENOG4105EGD	dinuclear metal center protein, YbgI family
FOL01_0823	ENOG4105D42	Cleaves the N-terminal amino acid of tripeptides (By similarity)
FOL01_0825	ENOG4108JIJ	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity)
FOL01_0827	ENOG41082QR	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
FOL01_0828	ENOG4108NUI	synthase
FOL01_0831	ENOG4108BRW	Activates expression of the rhaSR operon in response to L-rhamnose (By similarity)
FOL01_0832	ENOG4107RBJ	symporter
FOL01_0833	ENOG4105CRD	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity)
FOL01_0834	ENOG4105CKN	UDP-glucose-hexose-1-phosphate uridylyltransferase
FOL01_0836	ENOG4105DC8	reductase
FOL01_0838	ENOG410807C	QueT transporter
FOL01_0839	ENOG4106KNP	GTP-binding protein LepA C-terminus
FOL01_0842	ENOG4105DME	alpha-galactosidase
FOL01_0847	ENOG4105C5I	Dehydrogenase
FOL01_0848	ENOG4105CXG	d-lactate dehydrogenase
FOL01_0851	ENOG4105C7J	ABC transporter, permease
FOL01_0852	ENOG4108JEI	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity)
FOL01_0854	ENOG4105EXC	Acyl-transferase
FOL01_0856	ENOG4107Y70	Heat shock protein
FOL01_0865	ENOG4108K79	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
FOL01_0868	ENOG4105D01	(LipO)protein
FOL01_0869	ENOG4105D1Q	UPF0246 protein
FOL01_0870	ENOG4105CQ4	Transcriptional regulator
FOL01_0871	ENOG4107RBJ	symporter
FOL01_0872	ENOG4105DME	alpha-galactosidase
FOL01_0876	ENOG4105C26	Dehydrogenase
FOL01_0879	ENOG4108UMN	azlc family
FOL01_0880	ENOG4108JCI	Transcriptional regulator
FOL01_0883	ENOG4105VZ8	Transcriptional regulator
FOL01_0885	ENOG4105EEM	helicase
FOL01_0901	ENOG4108RB3	Capsular polysaccharide biosynthesis protein
FOL01_0903	ENOG4107YJ4	chain length determinant protein
FOL01_0904	ENOG4105D3Q	Sugar transferase
FOL01_0909	ENOG4105C6Y	Udp-glucose 6-dehydrogenase
FOL01_0910	ENOG4108I19	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity)
FOL01_0912	ENOG4105C1B	dTDP-glucose 4-6-dehydratase
FOL01_0913	ENOG4105DBZ	Dtdp-4-dehydrorhamnose reductase
FOL01_0916	ENOG4105DQ6	Transposase
FOL01_0927	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
FOL01_0932	ENOG41089N3	Inherit from COG: cobyrinic Acid a,c-diamide synthase
FOL01_0937	ENOG4105E4C	Lytic transglycosylase catalytic
FOL01_0945	ENOG4105ETE	Transcriptional regulator (LacI family
FOL01_0947	ENOG4105CG3	alpha amylase, catalytic region
FOL01_0949	ENOG4105FCD	Major Facilitator
FOL01_0952	ENOG4105DWF	phosphomethylpyrimidine kinase
FOL01_0953	ENOG4107QSE	Dipeptidase
FOL01_0955	ENOG41065RQ	ADP-ribosylation crystallin J1
FOL01_0957	ENOG4105CZ1	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity)
FOL01_0960	ENOG4105K59	histidine triad (HIT) protein
FOL01_0962	ENOG4105DUX	Transporter
FOL01_0963	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
FOL01_0966	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
FOL01_0967	ENOG4105C4R	Atp-dependent dna helicase
FOL01_0968	ENOG4105C4H	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity)
FOL01_0970	ENOG4108UKS	UPF0398 protein
FOL01_0971	ENOG4108UI2	Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity)
FOL01_0972	ENOG4105BZ4	penicillin-binding protein
FOL01_0974	ENOG4105C5S	asparaginyl-tRNA synthetase
FOL01_0976	ENOG4105DVT	helicase
FOL01_0977	ENOG4105CRD	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity)
FOL01_0980	ENOG4106UJV	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity)
FOL01_0981	ENOG41064MX	Tetr family transcriptional regulator
FOL01_0982	ENOG4107XQC	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins (By similarity)
FOL01_0984	ENOG4105GR3	Histidine kinase
FOL01_0985	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
FOL01_0990	ENOG4108ZQD	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity)
FOL01_0991	ENOG4105ERD	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity)
FOL01_0992	ENOG4105KA3	membrAne
FOL01_0993	ENOG4105CIS	alcohol dehydrogenase
FOL01_0994	ENOG4107QN2	dihydrolipoyl dehydrogenase
FOL01_0995	ENOG4105K56	Transcriptional regulator
FOL01_0997	ENOG4105I2S	Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity)
FOL01_1011	ENOG4105C2M	dna polymerase I
FOL01_1012	ENOG4105HFZ	Membrane
FOL01_1013	ENOG4105DFU	Cell wall formation (By similarity)
FOL01_1015	ENOG4108VDD	TRNA binding domain protein
FOL01_1016	ENOG4105CN9	Peptidase m42 family protein
FOL01_1017	ENOG4105DBI	uridine monophosphokinase
FOL01_1018	ENOG4105BZU	Histidine kinase
FOL01_1019	ENOG4105DPZ	Two component transcriptional regulator (Winged helix family
FOL01_1021	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
FOL01_1022	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
FOL01_1027	ENOG4105C9U	ATP-dependent DNA helicase RecQ
FOL01_1043	ENOG4105DQ6	Transposase
FOL01_1047	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
FOL01_1059	ENOG4107QMW	pyridine nucleotide-disulfide oxidoreductase
FOL01_1060	ENOG4105F9F	transposase
FOL01_1064	ENOG4105C93	Xylose Isomerase
FOL01_1067	ENOG4105ENN	converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity)
FOL01_1068	ENOG4105DSG	hydrolase family 43
FOL01_1069	ENOG4105CT4	transporter
FOL01_1070	ENOG4105C9U	ATP-dependent DNA helicase RecQ
FOL01_1076	ENOG4108IJ8	ABC transporter
FOL01_1084	ENOG4105M02	This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity)
FOL01_1093	ENOG4105DQ6	Transposase
FOL01_1105	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
FOL01_1109	ENOG4107BMA	Transglycosylase associated protein
FOL01_1112	ENOG4105C59	p-type ATPase
FOL01_1113	ENOG4105NA0	Transcriptional regulator
FOL01_1115	ENOG41090UD	(LipO)protein
FOL01_1116	ENOG41090UD	(LipO)protein
FOL01_1117	ENOG4105D5G	Transposase
FOL01_1120	ENOG4105DQ6	Transposase
FOL01_1123	ENOG4105DQ6	Transposase
FOL01_1136	ENOG41067QW	Transcriptional regulator
FOL01_1151	ENOG4105CUB	amino acid
FOL01_1152	ENOG4107URF	beta-phospho-glucomutase
FOL01_1153	ENOG4107URF	beta-phospho-glucomutase
FOL01_1154	ENOG4105C71	hydrolase family 65, central catalytic
FOL01_1155	ENOG4105C5Y	PTS System
FOL01_1157	ENOG4107414	GntR family transcriptional regulator
FOL01_1158	ENOG4105ETE	Transcriptional regulator (LacI family
FOL01_1159	ENOG4108HKT	sucrose-6-phosphate hydrolase
FOL01_1160	ENOG4105C5Y	PTS System
FOL01_1161	ENOG4105CA1	Removes the N-terminal methionine from nascent proteins (By similarity)
FOL01_1163	ENOG4108J59	Extracellular solute-binding protein, family 5
FOL01_1165	ENOG4107QN2	dihydrolipoyl dehydrogenase
FOL01_1166	ENOG4105C7S	Dehydrogenase
FOL01_1168	ENOG4107RUY	(E1 component), alpha subunit
FOL01_1169	ENOG4105DF9	Lipoate-protein, ligase
FOL01_1170	ENOG41063PX	domain protein
FOL01_1171	ENOG4108ZEF	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)
FOL01_1172	ENOG4106H78	methyltransferase
FOL01_1173	ENOG4105WUC	UPF0298 protein
FOL01_1174	ENOG4105CNI	cell division protein FtsW
FOL01_1175	ENOG4105CI3	gtp-binding protein typa
FOL01_1176	ENOG4105ECY	inositol monophosphatase
FOL01_1177	ENOG4105WBI	UPF0223 protein
FOL01_1183	ENOG4108HW8	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity)
FOL01_1184	ENOG4105D01	(LipO)protein
FOL01_1185	ENOG4107QMW	pyridine nucleotide-disulfide oxidoreductase
FOL01_1189	ENOG4108IJ7	Glycine betaine
FOL01_1191	ENOG4105E2M	Manganese-dependent inorganic pyrophosphatase
FOL01_1193	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
FOL01_1194	ENOG4105K7Z	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity)
FOL01_1196	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
FOL01_1197	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
FOL01_1198	ENOG4105C79	DNA protecting protein DprA
FOL01_1199	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
FOL01_1200	ENOG4105C9W	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity)
FOL01_1201	ENOG4105VSD	UPF0346 protein
FOL01_1203	ENOG41090WU	lipolytic protein G-D-S-L family
FOL01_1204	ENOG4108RCR	degv family
FOL01_1205	ENOG4105EPR	degv family
FOL01_1207	ENOG4106N3A	copper homeostasis protein cutc
FOL01_1208	ENOG4105F23	Fibronectin-binding protein
FOL01_1209	ENOG4105DTN	riboflavin biosynthesis protein ribF
FOL01_1210	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
FOL01_1211	ENOG4105KG7	Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity)
FOL01_1212	ENOG4107EEM	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
FOL01_1214	ENOG4105VZN	Nucleic-acid-binding protein implicated in transcription termination
FOL01_1215	ENOG4105CHV	Transcription elongation factor NusA
FOL01_1216	ENOG4105K7D	Required for maturation of 30S ribosomal subunits (By similarity)
FOL01_1217	ENOG4105CJW	magnesium transporter
FOL01_1218	ENOG4105EMS	pseudouridine synthase
FOL01_1219	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
FOL01_1223	ENOG4108V82	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
FOL01_1225	ENOG4107XGZ	Hydrolase
FOL01_1226	ENOG4105K63	Thioredoxin
FOL01_1227	ENOG4105C98	muts2 protein
FOL01_1228	ENOG4105C98	muts2 protein
FOL01_1229	ENOG4105C98	muts2 protein
FOL01_1230	ENOG4105C98	muts2 protein
FOL01_1234	ENOG4105WHM	Necessary for normal cell division and for the maintenance of normal septation (By similarity)
FOL01_1235	ENOG4105CHN	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
FOL01_1236	ENOG4105CHN	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
FOL01_1238	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
FOL01_1241	ENOG4105KQV	Binds directly to 16S ribosomal RNA (By similarity)
FOL01_1242	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
FOL01_1243	ENOG4105TQK	DNA polymerase iii, delta' subunit
FOL01_1244	ENOG4105EGY	DNA internalization-related competence protein ComEC Rec2
FOL01_1246	ENOG4105VPH	UPF0473 protein
FOL01_1247	ENOG4105VPH	UPF0473 protein
FOL01_1248	ENOG4108Z08	Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity)
FOL01_1249	ENOG4105VBH	UPF0297 protein
FOL01_1250	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
FOL01_1251	ENOG4105C1J	atp-dependent rna helicase
FOL01_1252	ENOG4105SFS	phosphoesterase RecJ domain protein
FOL01_1253	ENOG4105CQ3	Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity)
FOL01_1255	ENOG4105C6U	Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity)
FOL01_1256	ENOG4105E2N	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity)
FOL01_1258	ENOG4105KA4	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity)
FOL01_1261	ENOG4108ZK7	protein family UPF0029, Impact, N-terminal protein
FOL01_1262	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
FOL01_1263	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
FOL01_1264	ENOG4105RHA	ABC transporter, permease
FOL01_1265	ENOG4108IUX	(ABC) transporter
FOL01_1266	ENOG4105CNU	cell division protein FtsK
FOL01_1267	ENOG4108UIQ	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity)
FOL01_1269	ENOG4105HHQ	6-phosphogluconolactonase (EC 3.1.1.31)
FOL01_1270	ENOG4105DU1	integral membrane protein, terc
FOL01_1271	ENOG4105C38	Glycyl-tRNA synthetase beta subunit
FOL01_1272	ENOG4108HMW	glycyl-tRNA synthetase, alpha subunit
FOL01_1274	ENOG4105CWT	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity)
FOL01_1276	ENOG4105KGE	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity)
FOL01_1277	ENOG4105C9A	Phoh family
FOL01_1278	ENOG4105KTH	gatB Yqey
FOL01_1279	ENOG4105VCC	30S ribosomal protein S21
FOL01_1280	ENOG4107AYK	membrAne
FOL01_1281	ENOG4105C9M	aspartyl-trna synthetase
FOL01_1282	ENOG4105CUT	histidyl-tRNA synthetase
FOL01_1283	ENOG4105C5C	n-acetylmuramoyl-l-alanine amidase
FOL01_1285	ENOG4105F99	Hydroxymethylglutaryl-CoA synthase
FOL01_1286	ENOG4105CJS	Phosphopantothenoylcysteine decarboxylase
FOL01_1291	ENOG4105E2M	Manganese-dependent inorganic pyrophosphatase
FOL01_1292	ENOG4107FQX	Alpha-acetolactate decarboxylase
FOL01_1293	ENOG4108JPW	Aminotransferase
FOL01_1294	ENOG4107QHQ	amino acid
FOL01_1295	ENOG4105ETE	Transcriptional regulator (LacI family
FOL01_1296	ENOG4105DC7	peptidase M24
FOL01_1299	ENOG4105DPN	Oligoendopeptidase f
FOL01_1301	ENOG4108SQ7	Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis
FOL01_1302	ENOG41090SU	Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity)
FOL01_1303	ENOG4105CDW	Resistance protein
FOL01_1305	ENOG4108VY7	phosphate-starvation-inducible protein PsiE
FOL01_1328	ENOG4108TFU	terminase (Small subunit)
FOL01_1329	ENOG4107BMA	Transglycosylase associated protein
FOL01_1342	ENOG4108UUM	single-stranded DNA-binding protein
FOL01_1352	ENOG4108IMY	Transcriptional regulator
FOL01_1355	ENOG4105EYG	tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity)
FOL01_1359	ENOG410667J	hydrolase
FOL01_1360	ENOG4105M2E	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity)
FOL01_1361	ENOG4105ZMH	deoxynucleoside kinase
FOL01_1362	ENOG4107SN7	NLP P60 protein
FOL01_1363	ENOG4108HMR	Key enzyme in the regulation of glycerol uptake and metabolism (By similarity)
FOL01_1364	ENOG41069HH	4-oxalocrotonate tautomerase
FOL01_1365	ENOG4107AYK	membrAne
FOL01_1367	ENOG4108YY1	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity)
FOL01_1368	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
FOL01_1370	ENOG4105DKJ	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
FOL01_1371	ENOG4105K5M	30s ribosomal protein S16
FOL01_1372	ENOG4105CB9	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
FOL01_1374	ENOG4105CCP	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
FOL01_1375	ENOG4105CDB	Required for chromosome condensation and partitioning (By similarity)
FOL01_1376	ENOG4108ZBM	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity)
FOL01_1377	ENOG4105VNB	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
FOL01_1378	ENOG4105C6B	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity)
FOL01_1379	ENOG4105CB5	ATP-dependent DNA helicase recG
FOL01_1380	ENOG4105DP4	dak2 domain fusion protein ylov
FOL01_1382	ENOG4105VB9	50S ribosomal protein l28
FOL01_1384	ENOG4105DJV	ribulose-phosphate 3-epimerase
FOL01_1385	ENOG4105E06	May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity)
FOL01_1386	ENOG4105D9P	serine threonine protein kinase
FOL01_1387	ENOG4108ZF3	Phosphatase
FOL01_1388	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
FOL01_1389	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
FOL01_1390	ENOG4105C25	Primosomal protein n'
FOL01_1400	ENOG4105C7N	Xanthine uracil vitamin C permease
FOL01_1401	ENOG4105CDY	transcriptional regulatory protein
FOL01_1402	ENOG4105C7H	Helicase, RecD TraA family
FOL01_1404	ENOG4107RPC	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
FOL01_1408	ENOG41067XK	integral membrane protein
FOL01_1409	ENOG4105VR5	Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity)
FOL01_1410	ENOG4105CDK	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity)
FOL01_1411	ENOG4105CIT	This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity)
FOL01_1412	ENOG41087KY	Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity)
FOL01_1414	ENOG4105DMZ	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity)
FOL01_1415	ENOG4105CPY	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity)
FOL01_1416	ENOG4105CJN	penicillin-binding protein
FOL01_1418	ENOG4105CGJ	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity)
FOL01_1419	ENOG4108V6E	Cell division protein mraZ
FOL01_1421	ENOG4107TVK	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity)
FOL01_1422	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
FOL01_1423	ENOG4105CA9	Pyruvate kinase
FOL01_1424	ENOG4108IQI	permease
FOL01_1426	ENOG4105CKU	formyltetrahydrofolate synthetase
FOL01_1427	ENOG4108HW3	(ABC) transporter
FOL01_1428	ENOG4105CDA	abc transporter atp-binding protein
FOL01_1429	ENOG4105E5Q	amino acid AbC transporter
FOL01_1432	ENOG4105N3I	Involved in formation and maintenance of cell shape (By similarity)
FOL01_1433	ENOG4105DFF	Rod shape-determining protein mreb
FOL01_1434	ENOG4105W5Q	DNA repair protein (RadC
FOL01_1437	ENOG41082CG	Protein CrcB homolog
FOL01_1438	ENOG41082CG	Protein CrcB homolog
FOL01_1439	ENOG4108JEI	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity)
FOL01_1440	ENOG4105C7J	ABC transporter, permease
FOL01_1443	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
FOL01_1444	ENOG4105WAZ	(Glutaredoxin-like protein) NrdH
FOL01_1449	ENOG4105DUF	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity)
FOL01_1451	ENOG4108YZ4	nudix hydrolase
FOL01_1452	ENOG4105VEQ	Cold shock protein
FOL01_1455	ENOG4108ZW7	flagellar rod assembly protein muramidase flgj
FOL01_1456	ENOG4108JJ8	(ABC) transporter
FOL01_1457	ENOG4108JJ9	ABC, transporter
FOL01_1458	ENOG4105CFY	cytochrome d ubiquinol oxidase, subunit ii
FOL01_1459	ENOG4105C4M	(Ubiquinol oxidase) subunit I
FOL01_1460	ENOG4105C5I	Dehydrogenase
FOL01_1463	ENOG41060GV	RNA binding s1 domain protein
FOL01_1465	ENOG4105DQR	SNARE associated Golgi
FOL01_1466	ENOG4105ZAD	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity)
FOL01_1467	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
FOL01_1468	ENOG4105C4F	May be involved in recombinational repair of damaged DNA (By similarity)
FOL01_1469	ENOG4105XBY	Regulates arginine biosynthesis genes (By similarity)
FOL01_1470	ENOG4105DX0	Hemolysin A
FOL01_1471	ENOG4105CTB	Polyprenyl synthetase
FOL01_1472	ENOG41067QG	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
FOL01_1473	ENOG4105DVS	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
FOL01_1474	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
FOL01_1475	ENOG4108V7D	UPF0397 protein
FOL01_1478	ENOG4105CKA	Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity)
FOL01_1479	ENOG4105C22	threonyL-tRNA synthetase
FOL01_1481	ENOG4105DC6	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity)
FOL01_1482	ENOG4105D86	that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity)
FOL01_1484	ENOG4105CDE	UPF0348 protein
FOL01_1485	ENOG4105DXX	methyltransferase
FOL01_1487	ENOG4108WF2	Metal Dependent Phosphohydrolase
FOL01_1488	ENOG4108Z1W	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity)
FOL01_1490	ENOG4105CQW	ribosome biogenesis GTPase YqeH
FOL01_1491	ENOG4108WJV	had superfamily (subfamily IIIa) phosphatase
FOL01_1494	ENOG4105C0X	amino acid
FOL01_1495	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
FOL01_1496	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
FOL01_1497	ENOG4105C5H	ABC transporter
FOL01_1499	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
FOL01_1501	ENOG4108UT2	hemolysin iii
FOL01_1504	ENOG4107YZX	Universal stress protein
FOL01_1506	ENOG4105D1H	recombination factor protein RarA
FOL01_1508	ENOG4108JZF	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity)
FOL01_1510	ENOG4105C8A	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity)
FOL01_1511	ENOG4105EVI	UPF0374 protein
FOL01_1513	ENOG4108UTW	Plays a role in the regulation of phosphate uptake
FOL01_1514	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
FOL01_1515	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
FOL01_1516	ENOG4105E2Z	phosphate ABC transporter (Permease
FOL01_1517	ENOG4105C8U	phosphate abc transporter
FOL01_1518	ENOG4105CVA	phosphate
FOL01_1520	ENOG4105D4U	had-superfamily hydrolase, subfamily iia
FOL01_1521	ENOG4105MMD	transcriptional regulator
FOL01_1522	ENOG4107R8B	5'-nucleotidase
FOL01_1525	ENOG4105DC7	peptidase M24
FOL01_1526	ENOG4105DTQ	mandelate racemase muconate lactonizing
FOL01_1528	ENOG4105C4A	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity)
FOL01_1529	ENOG4105E4F	Isochorismate synthase
FOL01_1535	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
FOL01_1536	ENOG4107WD8	ABC transporter, permease
FOL01_1538	ENOG4107QN2	dihydrolipoyl dehydrogenase
FOL01_1546	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
FOL01_1552	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
FOL01_1555	ENOG4105DZR	Type I site-specific deoxyribonuclease
FOL01_1557	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
FOL01_1559	ENOG4105EKX	Restriction modification system DNA (Specificity
FOL01_1560	ENOG4105CVR	type I restriction-modification system
FOL01_1561	ENOG4105K46	50S ribosomal protein l27
FOL01_1566	ENOG4105C5F	glutamine synthetase
FOL01_1567	ENOG4105KV4	Transcriptional regulator
FOL01_1569	ENOG4108QXE	glycerophosphoryl diester phosphodiesterase
FOL01_1572	ENOG4105VRS	hydrolase family 18
FOL01_1573	ENOG4105DKQ	ROK family
FOL01_1576	ENOG4105MK2	5-formyltetrahydrofolate cyclo-ligase
FOL01_1577	ENOG4107RF6	penicillin-binding protein
FOL01_1579	ENOG4108UKH	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
FOL01_1580	ENOG4105C9U	ATP-dependent DNA helicase RecQ
FOL01_1582	ENOG4105C6A	phenylalanyl-tRNA synthetase (beta subunit)
FOL01_1583	ENOG4105CSS	phenylalanyl-tRNA synthetase (alpha subunit)
FOL01_1585	ENOG4105CZM	Major Facilitator
FOL01_1587	ENOG4108RWN	rrna methyltransferase
FOL01_1589	ENOG4105CG1	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity)
FOL01_1590	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
FOL01_1591	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
FOL01_1592	ENOG4105CTP	PilT protein domain protein
FOL01_1594	ENOG4107Z0P	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity)
FOL01_1596	ENOG4105K4H	Nlp p60 protein
FOL01_1597	ENOG41068JE	domain protein
FOL01_1598	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
FOL01_1599	ENOG4105CIS	alcohol dehydrogenase
FOL01_1600	ENOG4107FQX	Alpha-acetolactate decarboxylase
FOL01_1608	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
FOL01_1609	ENOG4105CIE	May be required for sporulation (By similarity)
FOL01_1610	ENOG4105CHW	UPF0052 protein
FOL01_1612	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
FOL01_1617	ENOG4108RG0	uracil-dna glycosylase
FOL01_1618	ENOG4105CG3	alpha amylase, catalytic region
FOL01_1621	ENOG4105DT3	PTS system, galactitol-specific IIc component
FOL01_1624	ENOG4105DK0	Indole-3-glycerol phosphate synthase
FOL01_1626	ENOG4105CG0	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
FOL01_1627	ENOG4105F6H	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity)
FOL01_1628	ENOG4105CMG	Carbohydrate kinase
FOL01_1629	ENOG4105C93	Xylose Isomerase
FOL01_1631	ENOG4107QNK	)-transporter
FOL01_1635	ENOG4105CZZ	Alpha-N-arabinofuranosidase (EC 3.2.1.55)
FOL01_1636	ENOG4108X79	transcriptional regulator
FOL01_1637	ENOG4105KPY	Small multidrug resistance protein
FOL01_1638	ENOG4105CPC	Aldo Keto reductase
FOL01_1639	ENOG4105K85	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity)
FOL01_1643	ENOG4105CVA	phosphate
FOL01_1646	ENOG4107RHR	regulatoR
FOL01_1647	ENOG4105MZU	cell filamentation protein
FOL01_1648	ENOG4105DU0	nucleoside hydrolase
FOL01_1650	ENOG4105CSH	Transporter
FOL01_1653	ENOG4105C2W	permease
FOL01_1654	ENOG4107QUY	Guanine deaminase
FOL01_1659	ENOG4105DZC	cytosine deaminase
FOL01_1660	ENOG4108UJD	30S ribosomal protein S9
FOL01_1661	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
FOL01_1662	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
FOL01_1664	ENOG4108JJB	ABC transporter
FOL01_1665	ENOG4108JJB	ABC transporter
FOL01_1668	ENOG4105DSE	periplasmic solute binding protein
FOL01_1669	ENOG4105CC5	ABC transporter
FOL01_1670	ENOG4105DIK	(ABC) transporter
FOL01_1672	ENOG4105KBC	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
FOL01_1673	ENOG4108VZM	50s ribosomal protein L10
FOL01_1674	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
FOL01_1675	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
FOL01_1676	ENOG4105E5V	Participates in transcription elongation, termination and antitermination (By similarity)
FOL01_1679	ENOG4105C2N	RNA methyltransferase TrmH family group 3
FOL01_1680	ENOG4105KEB	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
FOL01_1681	ENOG41065E1	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
FOL01_1682	ENOG4106EG9	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity)
FOL01_1683	ENOG4107RY0	Catalyzes the conversion of dihydroorotate to orotate (By similarity)
FOL01_1684	ENOG4105CU6	carbamoyl-phosphate synthetase ammonia chain
FOL01_1685	ENOG4105C1M	carbamoyl-phosphate synthetase glutamine chain
FOL01_1686	ENOG4105CD3	dihydroorotase
FOL01_1687	ENOG4105CXT	aspartate transcarbamylase
FOL01_1688	ENOG4105C2X	Arabinose 5-phosphate isomerase
FOL01_1689	ENOG4105CXR	Phospho-2-dehydro-3-deoxyoctonate aldolase
FOL01_1690	ENOG4106762	Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity)
FOL01_1691	ENOG4105C8N	cysteinyl-tRNA synthetase
FOL01_1692	ENOG4105CPC	Aldo Keto reductase
FOL01_1693	ENOG4107RA1	nh(3)-dependent nad( ) synthetase
FOL01_1694	ENOG4105DAP	Nicotinate phosphoribosyltransferase
FOL01_1696	ENOG4105D01	(LipO)protein
FOL01_1697	ENOG4108JEI	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity)
FOL01_1698	ENOG4108UMI	ABC transporter, permease
FOL01_1701	ENOG4105CTF	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
FOL01_1702	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
FOL01_1703	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
FOL01_1704	ENOG4105K9U	however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)
FOL01_1706	ENOG4105CGG	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity)
FOL01_1707	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
FOL01_1708	ENOG4105VPB	50S ribosomal protein L30
FOL01_1709	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
FOL01_1711	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
FOL01_1712	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
FOL01_1713	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
FOL01_1714	ENOG4105KAR	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity)
FOL01_1715	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
FOL01_1716	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
FOL01_1717	ENOG41082SA	50s ribosomal protein l29
FOL01_1718	ENOG4108R70	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity)
FOL01_1719	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
FOL01_1720	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
FOL01_1722	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
FOL01_1723	ENOG41080UE	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
FOL01_1724	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
FOL01_1725	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
FOL01_1726	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
FOL01_1727	ENOG4105F9F	transposase
FOL01_1728	ENOG4105EAH	synthase
FOL01_1729	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
FOL01_1732	ENOG41072GX	Peptidase M22 Glycoprotease
FOL01_1734	ENOG4105CMR	udp-glucose 4-epimerase
FOL01_1736	ENOG4105CU0	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity)
FOL01_1738	ENOG4105X0R	protein from nitrogen regulatory protein P-II
FOL01_1739	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
FOL01_1741	ENOG4105F3K	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity)
FOL01_1742	ENOG410816I	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity)
FOL01_1743	ENOG4105C6E	dna polymerase iii
FOL01_1745	ENOG4107Y49	methyltransferase
FOL01_1749	ENOG4107QNK	)-transporter
FOL01_1754	ENOG4105DHI	Methyltransferase
FOL01_1755	ENOG4107QW4	alcohol dehydrogenase
FOL01_1756	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
FOL01_1757	ENOG4108IIJ	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
FOL01_1758	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
FOL01_1759	ENOG4105KEX	transcriptional regulator, ctsr
FOL01_1760	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
FOL01_1761	ENOG4105ZMH	deoxynucleoside kinase
FOL01_1762	ENOG4105KNM	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
FOL01_1763	ENOG4105C4J	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
FOL01_1764	ENOG4105J80	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity)
FOL01_1765	ENOG4105CDG	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity)
FOL01_1766	ENOG4107YZM	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
FOL01_1767	ENOG4107ZFM	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity)
FOL01_1768	ENOG4105WS6	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
FOL01_1773	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
FOL01_1774	ENOG4105EK0	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
FOL01_1775	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
FOL01_1777	ENOG4107104	thymidine kinase
FOL01_1778	ENOG4105F1K	Glutamine amidotransferase
FOL01_1779	ENOG4105DMS	mur ligase
FOL01_1780	ENOG4105DG6	mannose-6-phosphate isomerase
FOL01_1782	ENOG4105BZ1	(ABC) transporter
FOL01_1783	ENOG4105BZ1	(ABC) transporter
FOL01_1784	ENOG4105C1N	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity)
FOL01_1785	ENOG4105DKJ	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
FOL01_1786	ENOG4105CGK	Exodeoxyribonuclease III
FOL01_1787	ENOG4108EKI	Dehydrogenase
FOL01_1788	ENOG4105C59	p-type ATPase
FOL01_1791	ENOG4105NA0	Transcriptional regulator
FOL01_1792	ENOG4105C9K	Endothelin-converting enzyme 1
FOL01_1794	ENOG4107QRI	Phosphoketolase
FOL01_1795	ENOG4108TZY	GntR Family Transcriptional Regulator
FOL01_1796	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
FOL01_1800	ENOG4105EAD	ABC transporter
FOL01_1801	ENOG4105CDA	abc transporter atp-binding protein
FOL01_1802	ENOG4105E5Q	amino acid AbC transporter
FOL01_1807	ENOG4105CAC	Catalyzes the conversion of L-arabinose to L-ribulose (By similarity)
FOL01_1811	ENOG4107R73	Mate efflux family protein
FOL01_1812	ENOG4107QNK	)-transporter
FOL01_1813	ENOG4105C5H	ABC transporter
FOL01_1815	ENOG4105FDK	ABC transporter
FOL01_1817	ENOG4107DA6	Transcriptional regulator
FOL01_1818	ENOG4105EXC	Acyl-transferase
FOL01_1821	ENOG4105DUX	Transporter
FOL01_1828	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
FOL01_1830	ENOG4105C3G	gtp-binding protein
FOL01_1832	ENOG4105FA0	parb-like partition protein
FOL01_1833	ENOG4107QJE	Chromosome Partitioning Protein
FOL01_1835	ENOG4105CEN	a g-specific adenine glycosylase
FOL01_1836	ENOG4105E66	phosphoriboisomerase A
FOL01_1837	ENOG4105US7	Histidine kinase
FOL01_1838	ENOG4108STX	response regulator
FOL01_1839	ENOG4107QTZ	amino acid
FOL01_1841	ENOG4105CEY	Amp-dependent synthetase and ligase
FOL01_1842	ENOG4108IPT	Naphthoate synthase
FOL01_1844	ENOG4105VEM	Conserved domain protein
FOL01_1845	ENOG4105HDK	L-asparaginase
FOL01_1846	ENOG4105CUB	amino acid
FOL01_1848	ENOG4105DIW	FeS assembly protein SUFB
FOL01_1849	ENOG4108UNV	SUF system FeS assembly protein, NifU family
FOL01_1851	ENOG4105JRK	feS assembly protein SufD
FOL01_1852	ENOG4105C3K	feS assembly ATPase SufC
FOL01_1853	ENOG4108RDD	Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity)
FOL01_1854	ENOG4105CJD	(Anaerobic) ribonucleoside-triphosphate reductase
FOL01_1860	ENOG4107R7I	amino acid
FOL01_1862	ENOG4105EE6	Alcohol dehydrogenase zinc-binding domain protein
FOL01_1863	ENOG4108W5N	phosphatidylglycerophosphatase a
FOL01_1864	ENOG4105D8C	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity)
FOL01_1866	ENOG4107U9W	Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S- specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX (By similarity)
FOL01_1868	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
FOL01_1869	ENOG4105CQ3	Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity)
FOL01_1871	ENOG4105CUB	amino acid
FOL01_1875	ENOG4105HMI	Membrane
FOL01_1877	ENOG4105C26	Dehydrogenase
FOL01_1879	ENOG4105CHR	reductase
FOL01_1884	ENOG4105C85	amino acid
FOL01_1889	ENOG410855V	Acylphosphatase
FOL01_1890	ENOG4105EAB	amino acid AbC transporter
FOL01_1891	ENOG4105E5Q	amino acid AbC transporter
FOL01_1892	ENOG4105CDA	abc transporter atp-binding protein
FOL01_1895	ENOG4105CHR	reductase
FOL01_1902	ENOG4105CHM	Aminotransferase
FOL01_1903	ENOG4105CQB	FAD linked oxidase domain protein
FOL01_1904	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
FOL01_1906	ENOG4105DIH	basic membrane
FOL01_1907	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
FOL01_1908	ENOG4105C2S	Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity)
FOL01_1909	ENOG4105CGT	Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity)
FOL01_1911	ENOG4105BZC	d-serine deaminase
FOL01_1913	ENOG4105U0F	oligosaccharide H symporter, major facilitator superfamily (MFS)
FOL01_1914	ENOG4105CUK	Alpha-N-arabinofuranosidase (EC 3.2.1.55)
FOL01_1915	ENOG41082BM	Transcriptional regulator, arsr family
FOL01_1917	ENOG4105CYX	Short-chain dehydrogenase reductase Sdr
FOL01_1918	ENOG41079KZ	Major Facilitator Superfamily
FOL01_1926	ENOG4107QUY	Guanine deaminase
FOL01_1927	ENOG41080Y5	BioY family
FOL01_1928	ENOG4105HJX	Biotin- acetyl-CoA-carboxylase ligase
FOL01_1932	ENOG4107YB6	acetyltransferase, (GNAT) family
FOL01_1934	ENOG4108JZF	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity)
FOL01_1935	ENOG4105CV8	reductase
FOL01_1937	ENOG4105CJ1	ABC, transporter
FOL01_1941	ENOG4105FKQ	transcriptional regulator
FOL01_1942	ENOG4105KIS	phospholipid-binding protein
FOL01_1943	ENOG4105C5I	Dehydrogenase
FOL01_1944	ENOG4105CHM	Aminotransferase
FOL01_1945	ENOG4108UW5	maltose o-acetyltransferase
FOL01_1946	ENOG4108UW5	maltose o-acetyltransferase
FOL01_1947	ENOG4105F4P	)-transporter
FOL01_1949	ENOG4107QTZ	amino acid
FOL01_1953	ENOG4105BZA	Phosphoglycerate kinase
FOL01_1954	ENOG4105C5I	Dehydrogenase
FOL01_1957	ENOG4105ENN	converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity)
FOL01_1958	ENOG4105CHM	Aminotransferase
FOL01_1959	ENOG4105C5I	Dehydrogenase
FOL01_1961	ENOG4105C7N	Xanthine uracil vitamin C permease
FOL01_1963	ENOG4105CVG	Homoserine O-transsuccinylase
FOL01_1968	ENOG4105CZE	histidine utilization repressor
FOL01_1969	ENOG4108UMW	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
FOL01_1970	ENOG4108HCJ	Hydrolase
FOL01_1975	ENOG4105JAB	phenazine biosynthesis protein, phzf family
FOL01_1976	ENOG4105CR8	Transcriptional regulator
FOL01_1978	ENOG4105D6E	homoserine dehydrogenase
FOL01_1979	ENOG4105C28	cystathionine
FOL01_1980	ENOG4105C28	cystathionine
FOL01_1981	ENOG4105DRP	amino acid AbC transporter
FOL01_1982	ENOG4105CDA	abc transporter atp-binding protein
FOL01_1983	ENOG4105EAB	amino acid AbC transporter
FOL01_1987	ENOG4108U05	Transcriptional regulator
FOL01_1995	ENOG4105CK2	sodium dicarboxylate symporter
FOL01_1996	ENOG4105CE7	Amidase, hydantoinase carbamoylase family
FOL01_1997	ENOG4105CA8	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity)
FOL01_2003	ENOG4105C85	amino acid
FOL01_2004	ENOG4107ZYR	domain protein
FOL01_2005	ENOG4106ST0	Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity)
FOL01_2009	ENOG4105E0A	ABC, transporter
FOL01_2011	ENOG4105E5Q	amino acid AbC transporter
FOL01_2012	ENOG4107XKZ	Amino acid ABC superfamily ATP binding cassette transporter binding protein
FOL01_2014	ENOG4105C3F	Signal peptidase i
FOL01_2015	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
FOL01_2016	ENOG4105M7T	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)
FOL01_p004	ENOG4105IJJ	transcriptional regulator, crp fnr family
FOL01_p005	ENOG4107QN2	dihydrolipoyl dehydrogenase
FOL01_p006	ENOG4107QN2	dihydrolipoyl dehydrogenase
FOL01_p011	ENOG4105ENN	converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity)
FOL01_p012	ENOG4107URF	beta-phospho-glucomutase
FOL01_p018	ENOG4108C33	Resolvase
FOL01_p030	ENOG4108UXE	Protein tyrosine phosphatase
FOL01_p032	ENOG4105HUF	DNA protection during starvation protein
FOL01_p050	ENOG41083J0	(ABC) transporter
FOL01_p051	ENOG4105C4B	ABC transporter, permease