locus-tag	class	description
WKK_00055	COG0346	lactoylglutathione lyase activity
WKK_00090	COG3409	Peptidoglycan-binding domain 1 protein
WKK_00150	COG1063	alcohol dehydrogenase
WKK_00165	COG0028	Belongs to the TPP enzyme family
WKK_00170	COG1695	Transcriptional regulator
WKK_00175	COG3479	Phenolic acid decarboxylase
WKK_00180	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
WKK_00220	COG0653	protein targeting
WKK_00235	COG0438	transferase activity, transferring glycosyl groups
WKK_00240	COG2233	PERMEase
WKK_00245	COG2217	Heavy metal translocating P-type atpase
WKK_00260	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
WKK_00265	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
WKK_00270	COG1288	antiporter activity
WKK_00275	COG0477	Major facilitator Superfamily
WKK_00280	COG0481	GTPase activity
WKK_00290	COG1309	transcriptional regulator
WKK_00315	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
WKK_00320	COG0267	Belongs to the bacterial ribosomal protein bL33 family
WKK_00330	COG2195	Cleaves the N-terminal amino acid of tripeptides
WKK_00335	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
WKK_00340	COG2384	SAM-dependent methyltransferase
WKK_00365	COG2807	transmembrane transport
WKK_00370	COG4720	Psort location CytoplasmicMembrane, score
WKK_00375	COG0351	phosphomethylpyrimidine kinase
WKK_00380	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
WKK_00380	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
WKK_00385	COG1668	transmembrane transport
WKK_00390	COG4152	abc transporter atp-binding protein
WKK_00400	COG0604	alcohol dehydrogenase
WKK_00405	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
WKK_00410	COG0516	GMP reductase activity
WKK_00415	COG0706	membrane insertase activity
WKK_00425	COG0765	amino acid transport
WKK_00430	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WKK_00440	COG3480	Lon protease (S16) C-terminal proteolytic domain
WKK_00450	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
WKK_00455	COG0742	ribosomal rna small subunit methyltransferase
WKK_00460	COG4471	UPF0298 protein
WKK_00465	COG0772	Belongs to the SEDS family
WKK_00475	COG0483	inositol monophosphate 1-phosphatase activity
WKK_00485	COG0242	peptide deformylase activity
WKK_00495	COG1876	peptidase activity
WKK_00510	COG1597	lipid kinase activity
WKK_00515	COG1227	inorganic diphosphatase activity
WKK_00525	COG0187	DNA topoisomerase II activity
WKK_00530	COG1739	Uncharacterized protein family UPF0029
WKK_00540	COG0322	excinuclease ABC activity
WKK_00545	COG0406	alpha-ribazole phosphatase activity
WKK_00555	COG0336	Belongs to the RNA methyltransferase TrmD family
WKK_00560	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
WKK_00575	COG0477	Major facilitator Superfamily
WKK_00580	COG0228	four-way junction DNA binding
WKK_00585	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
WKK_00590	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
WKK_00595	COG0552	protein localization to endoplasmic reticulum
WKK_00600	COG0571	ribonuclease III activity
WKK_00605	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
WKK_00610	COG0416	fatty acid biosynthetic process
WKK_00615	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
WKK_00620	COG2252	PERMEase
WKK_00625	COG0018	arginyl-trna synthetase
WKK_00645	COG0501	Belongs to the peptidase M48B family
WKK_00650	COG1704	LemA family
WKK_00655	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
WKK_00660	COG1461	Dihydroxyacetone kinase
WKK_00670	COG0227	Belongs to the bacterial ribosomal protein bL28 family
WKK_00675	COG1564	THIamine pyrophosphokinase
WKK_00680	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
WKK_00685	COG1162	GTPase activity
WKK_00690	COG2815	serine threonine protein kinase
WKK_00690	COG0515	serine threonine protein kinase
WKK_00695	COG0631	protein serine/threonine phosphatase activity
WKK_00700	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
WKK_00700	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
WKK_00705	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
WKK_00710	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
WKK_00715	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
WKK_00750	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
WKK_00765	COG1942	4-Oxalocrotonate Tautomerase
WKK_00770	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
WKK_00775	COG0513	Belongs to the DEAD box helicase family
WKK_00780	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
WKK_00785	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
WKK_00790	COG1862	Preprotein translocase
WKK_00795	COG0343	queuine tRNA-ribosyltransferase activity
WKK_00800	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
WKK_00805	COG2255	four-way junction helicase activity
WKK_00810	COG0632	four-way junction helicase activity
WKK_00820	COG0758	DNA mediated transformation
WKK_00825	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
WKK_00835	COG4479	Belongs to the UPF0346 family
WKK_00850	COG1307	EDD domain protein, DegV family
WKK_00855	COG1307	EDD domain protein, DegV family
WKK_00865	COG0446	pyridine nucleotide-disulphide oxidoreductase
WKK_00870	COG5002	protein histidine kinase activity
WKK_00875	COG0745	RESPONSE REGULATOR receiver
WKK_00890	COG1484	DNA-dependent DNA replication
WKK_00905	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
WKK_00915	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
WKK_00920	COG0220	tRNA (guanine-N7-)-methyltransferase activity
WKK_00925	COG0537	adenosine 5'-monophosphoramidase activity
WKK_00935	COG3759	membrane
WKK_00940	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
WKK_00960	COG4221	oxidoreductase activity
WKK_00965	COG0583	DNA-binding transcription factor activity
WKK_00970	COG2261	transglycosylase associated protein
WKK_00995	COG3237	CsbD-like
WKK_01010	COG2261	transglycosylase associated protein
WKK_01020	COG1461	Dihydroxyacetone kinase
WKK_01025	COG1942	4-Oxalocrotonate Tautomerase
WKK_01035	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
WKK_01040	COG2226	methyltransferase
WKK_01150	COG0582	viral genome integration into host DNA
WKK_01155	COG1609	Transcriptional regulator
WKK_01160	COG0006	proline dipeptidase activity
WKK_01165	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
WKK_01170	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
WKK_01185	COG1846	Transcriptional regulator
WKK_01190	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
WKK_01195	COG3599	regulation of cell shape
WKK_01210	COG1799	cell septum assembly
WKK_01225	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
WKK_01230	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
WKK_01235	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
WKK_01240	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
WKK_01255	COG0275	rRNA processing
WKK_01260	COG2001	Belongs to the MraZ family
WKK_01270	COG1385	rRNA (uridine-N3-)-methyltransferase activity
WKK_01275	COG2264	protein methyltransferase activity
WKK_01280	COG0833	amino acid
WKK_01300	COG1077	Cell shape determining protein MreB Mrl
WKK_01305	COG2003	Belongs to the UPF0758 family
WKK_01335	COG0561	phosphatase activity
WKK_01340	COG0363	glucosamine-6-phosphate deaminase activity
WKK_01345	COG2207	Transcriptional regulator
WKK_01355	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
WKK_01390	COG0254	rRNA binding
WKK_01400	COG0335	large ribosomal subunit rRNA binding
WKK_01410	COG3481	metal-dependent phosphohydrolase, HD sub domain
WKK_01415	COG4717	serine-type aminopeptidase activity
WKK_01420	COG0420	3'-5' exonuclease activity
WKK_01425	COG3679	Belongs to the UPF0342 family
WKK_01430	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
WKK_01435	COG1438	arginine binding
WKK_01445	COG1136	(ABC) transporter
WKK_01450	COG0268	Binds directly to 16S ribosomal RNA
WKK_01455	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
WKK_01460	COG1466	dna polymerase III delta subunit
WKK_01465	COG2333	competence protein COMEC
WKK_01465	COG0658	competence protein
WKK_01470	COG1596	polysaccharide export
WKK_01470	COG1555	photosystem II stabilization
WKK_01490	COG3906	Belongs to the UPF0473 family
WKK_01495	COG3906	Belongs to the UPF0473 family
WKK_01505	COG4472	Bacterial protein of unknown function (DUF965)
WKK_01510	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
WKK_01515	COG2814	Major facilitator Superfamily
WKK_01520	COG2239	Acts as a magnesium transporter
WKK_01525	COG0564	pseudouridine synthase activity
WKK_01530	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
WKK_01535	COG2357	RelA SpoT domain protein
WKK_01540	COG0562	UDP-galactopyranose mutase
WKK_01545	COG1216	Glycosyl transferase, family 2
WKK_01555	COG1758	RNA polymerase activity
WKK_01560	COG0194	GDP metabolic process
WKK_01565	COG0497	DNA recombination
WKK_01570	COG1438	arginine binding
WKK_01575	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
WKK_01580	COG0142	geranyltranstransferase activity
WKK_01585	COG1722	exodeoxyribonuclease VII activity
WKK_01595	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
WKK_01600	COG0513	Belongs to the DEAD box helicase family
WKK_01605	COG0673	inositol 2-dehydrogenase activity
WKK_01610	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
WKK_01620	COG0525	valine-tRNA ligase activity
WKK_01640	COG4175	Glycine betaine
WKK_01640	COG3448	diguanylate cyclase activity
WKK_01645	COG0589	response to stress
WKK_01665	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
WKK_01670	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
WKK_01680	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
WKK_01685	COG2084	Dehydrogenase
WKK_01690	COG0656	L-ascorbic acid biosynthetic process
WKK_01695	COG2814	Major facilitator Superfamily
WKK_01700	COG2160	L-arabinose isomerase activity
WKK_01715	COG2211	Major facilitator Superfamily
WKK_01720	COG3940	Belongs to the glycosyl hydrolase 43 family
WKK_01725	COG1609	Transcriptional regulator
WKK_01730	COG3706	GGDEF domain
WKK_01760	COG4120	Belongs to the binding-protein-dependent transport system permease family
WKK_01770	COG4720	Psort location CytoplasmicMembrane, score
WKK_01780	COG2814	Major facilitator Superfamily
WKK_01790	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
WKK_01800	COG1230	cation diffusion facilitator family transporter
WKK_01805	COG0741	lytic transglycosylase activity
WKK_01810	COG1072	(Pantothenic acid kinase))
WKK_01815	COG3973	AAA domain
WKK_01825	COG3716	PTS system mannose fructose sorbose family IID component
WKK_01830	COG3715	PTS system
WKK_01885	COG3583	domain protein
WKK_01885	COG3064	Membrane
WKK_01885	COG3525	Glycosyl hydrolase, family 20, catalytic domain
WKK_01915	COG1368	sulfuric ester hydrolase activity
WKK_01930	COG0438	transferase activity, transferring glycosyl groups
WKK_01935	COG0438	transferase activity, transferring glycosyl groups
WKK_01945	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
WKK_01950	COG4856	YbbR-like protein
WKK_01965	COG0812	UDP-N-acetylmuramate dehydrogenase activity
WKK_01980	COG0802	atpase or kinase
WKK_01985	COG0280	phosphate acetyltransferase
WKK_01990	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
WKK_02005	COG1983	PspC domain protein
WKK_02020	COG0735	belongs to the Fur family
WKK_02030	COG2070	2-Nitropropane dioxygenase
WKK_02040	COG1929	Belongs to the glycerate kinase type-1 family
WKK_02045	COG0024	Methionine aminopeptidase
WKK_02075	COG0789	Transcriptional regulator
WKK_02100	COG1136	(ABC) transporter
WKK_02105	COG0577	efflux transmembrane transporter activity
WKK_02120	COG0211	Belongs to the bacterial ribosomal protein bL27 family
WKK_02125	COG0261	This protein binds to 23S rRNA in the presence of protein L20
WKK_02130	COG0305	Participates in initiation and elongation during chromosome replication
WKK_02135	COG0359	binds to the 23S rRNA
WKK_02145	COG0765	amino acid transport
WKK_02150	COG0765	amino acid transport
WKK_02155	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WKK_02175	COG1136	(ABC) transporter
WKK_02175	COG0577	efflux transmembrane transporter activity
WKK_02180	COG1132	(ABC) transporter
WKK_02185	COG1132	(ABC) transporter
WKK_02195	COG0588	phosphoglycerate mutase activity
WKK_02200	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
WKK_02205	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
WKK_02220	COG1609	Transcriptional regulator
WKK_02225	COG0708	Exodeoxyribonuclease III
WKK_02240	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
WKK_02245	COG0772	Belongs to the SEDS family
WKK_02255	COG1077	Cell shape determining protein MreB Mrl
WKK_02260	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
WKK_02275	COG0352	thiamine-phosphate diphosphorylase activity
WKK_02280	COG0351	phosphomethylpyrimidine kinase
WKK_02285	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
WKK_02290	COG1511	domain protein
WKK_02300	COG3250	beta-galactosidase activity
WKK_02310	COG0588	phosphoglycerate mutase activity
WKK_02315	COG0492	ferredoxin-NADP+ reductase activity
WKK_02330	COG0596	Alpha beta hydrolase
WKK_02335	COG1733	regulation of RNA biosynthetic process
WKK_02345	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
WKK_02355	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
WKK_02360	COG0653	protein targeting
WKK_02365	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
WKK_02380	COG2337	Toxic component of a toxin-antitoxin (TA) module
WKK_02395	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
WKK_02400	COG0504	CTP synthase activity
WKK_02410	COG1091	dTDP-4-dehydrorhamnose reductase activity
WKK_02415	COG1088	dTDP-glucose 4,6-dehydratase activity
WKK_02425	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
WKK_02430	COG0438	transferase activity, transferring glycosyl groups
WKK_02440	COG1215	transferase activity, transferring glycosyl groups
WKK_02460	COG0438	transferase activity, transferring glycosyl groups
WKK_02465	COG0438	transferase activity, transferring glycosyl groups
WKK_02470	COG1078	dGTPase activity
WKK_02480	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
WKK_02485	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
WKK_02500	COG5002	protein histidine kinase activity
WKK_02505	COG0745	RESPONSE REGULATOR receiver
WKK_02510	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
WKK_02515	COG0629	single-stranded DNA binding
WKK_02520	COG0360	Binds together with S18 to 16S ribosomal RNA
WKK_02525	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
WKK_02530	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
WKK_02535	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
WKK_02540	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
WKK_02550	COG1074	ATP-dependent DNA helicase activity
WKK_02555	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
WKK_02565	COG2813	Specifically methylates the guanine in position
WKK_02580	COG1064	alcohol dehydrogenase
WKK_02585	COG0203	ribosomal protein L17
WKK_02590	COG0202	RNA polymerase activity
WKK_02595	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
WKK_02600	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
WKK_02610	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
WKK_02615	COG0563	adenylate kinase activity
WKK_02625	COG0200	Binds to the 23S rRNA
WKK_02630	COG1841	ribosomal large subunit assembly
WKK_02635	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
WKK_02640	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
WKK_02645	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
WKK_02650	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
WKK_02655	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
WKK_02660	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
WKK_02665	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
WKK_02675	COG0255	Belongs to the universal ribosomal protein uL29 family
WKK_02680	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
WKK_02685	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
WKK_02690	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
WKK_02695	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
WKK_02700	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
WKK_02705	COG0089	rRNA binding
WKK_02715	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
WKK_02720	COG0051	transcription antitermination factor activity, RNA binding
WKK_02750	COG0438	transferase activity, transferring glycosyl groups
WKK_02760	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
WKK_02765	COG2244	polysaccharide biosynthetic process
WKK_02785	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
WKK_02800	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
WKK_02810	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
WKK_02815	COG0456	acetyltransferase
WKK_02825	COG1214	PFAM Peptidase M22, glycoprotease
WKK_02855	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
WKK_02860	COG1428	Deoxynucleoside kinase
WKK_02865	COG0355	proton-transporting ATP synthase activity, rotational mechanism
WKK_02870	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
WKK_02875	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
WKK_02880	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
WKK_02890	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
WKK_02895	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
WKK_02900	COG0356	it plays a direct role in the translocation of protons across the membrane
WKK_02905	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
WKK_02910	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
WKK_02915	COG0009	L-threonylcarbamoyladenylate synthase
WKK_02920	COG2890	protein-(glutamine-N5) methyltransferase activity
WKK_02930	COG1435	thymidine kinase activity
WKK_02935	COG3442	glutamine amidotransferase
WKK_02940	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
WKK_02950	COG0531	amino acid
WKK_02965	COG0500	methyltransferase
WKK_02970	COG0531	amino acid
WKK_02975	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
WKK_02990	COG2244	polysaccharide biosynthetic process
WKK_03000	COG0495	leucyl-tRNA aminoacylation
WKK_03005	COG0671	phosphoesterase, PA-phosphatase related
WKK_03015	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
WKK_03020	COG1114	Component of the transport system for branched-chain amino acids
WKK_03025	COG0531	amino acid
WKK_03035	COG0531	amino acid
WKK_03050	COG1957	nucleoside hydrolase
WKK_03055	COG1136	(ABC) transporter
WKK_03060	COG0577	efflux transmembrane transporter activity
WKK_03065	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
WKK_03070	COG0784	Response regulator, receiver
WKK_03075	COG4251	negative regulation of phosphorylation
WKK_03080	COG1288	antiporter activity
WKK_03090	COG1869	D-ribose catabolic process
WKK_03100	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
WKK_03135	COG1174	glycine betaine transport
WKK_03140	COG1522	sequence-specific DNA binding
WKK_03150	COG0222	ribosome binding
WKK_03155	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
WKK_03160	COG0081	regulation of translation
WKK_03165	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
WKK_03170	COG0250	Participates in transcription elongation, termination and antitermination
WKK_03190	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
WKK_03195	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
WKK_03200	COG0215	cysteine-tRNA ligase activity
WKK_03205	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
WKK_03210	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
WKK_03225	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
WKK_03240	COG1482	cell wall glycoprotein biosynthetic process
WKK_03255	COG1272	protein, Hemolysin III
WKK_03260	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
WKK_03265	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
WKK_03270	COG2188	Transcriptional regulator
WKK_03275	COG2814	Major facilitator Superfamily
WKK_03300	COG0488	(ABC) transporter
WKK_03305	COG1108	ABC-type Mn2 Zn2 transport systems permease components
WKK_03310	COG1121	(ABC) transporter
WKK_03325	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
WKK_03325	COG2755	lipolytic protein G-D-S-L family
WKK_03335	COG3104	oligopeptide transport
WKK_03345	COG0300	oxidoreductase activity
WKK_03355	COG5002	protein histidine kinase activity
WKK_03370	COG0012	GTP binding
WKK_03375	COG4481	Protein conserved in bacteria
WKK_03380	COG1475	DNA binding
WKK_03385	COG1192	Involved in chromosome partitioning
WKK_03390	COG0357	Ribosomal RNA small subunit methyltransferase G
WKK_03395	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
WKK_03415	COG0628	permease
WKK_03420	COG1254	Belongs to the acylphosphatase family
WKK_03425	COG1881	PFAM PEBP family protein
WKK_03435	COG4221	oxidoreductase activity
WKK_03440	COG0789	Transcriptional regulator
WKK_03445	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
WKK_03450	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
WKK_03470	COG1959	2 iron, 2 sulfur cluster binding
WKK_03490	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
WKK_03505	COG0702	epimerase
WKK_03510	COG0667	Aldo Keto reductase
WKK_03515	COG0586	Pfam SNARE associated Golgi protein
WKK_03525	COG0328	RNA-DNA hybrid ribonuclease activity
WKK_03530	COG0561	phosphatase activity
WKK_03535	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
WKK_03540	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
WKK_03560	COG1131	(ABC) transporter
WKK_03635	COG0492	ferredoxin-NADP+ reductase activity
WKK_03640	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
WKK_03645	COG3118	belongs to the thioredoxin family
WKK_03650	COG3118	belongs to the thioredoxin family
WKK_03660	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
WKK_03690	COG0656	L-ascorbic acid biosynthetic process
WKK_03700	COG0583	DNA-binding transcription factor activity
WKK_03725	COG1902	pentaerythritol trinitrate reductase activity
WKK_03735	COG0789	Transcriptional regulator
WKK_03740	COG0583	DNA-binding transcription factor activity
WKK_03750	COG1285	pathogenesis
WKK_03755	COG1063	alcohol dehydrogenase
WKK_03765	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
WKK_03805	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
WKK_03815	COG0583	DNA-binding transcription factor activity
WKK_03820	COG1442	glycosyl transferase family 8
WKK_03825	COG0569	domain protein
WKK_03830	COG1113	amino acid transport
WKK_03840	COG0706	membrane insertase activity
WKK_03845	COG0594	ribonuclease P activity
WKK_03850	COG0230	Belongs to the bacterial ribosomal protein bL34 family
WKK_03855	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
WKK_03860	COG0592	DNA-directed DNA polymerase activity
WKK_03865	COG2501	S4 domain
WKK_03870	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
WKK_03875	COG0187	DNA topoisomerase II activity
WKK_03885	COG1368	sulfuric ester hydrolase activity
WKK_03905	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
WKK_03905	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
WKK_03910	COG0084	hydrolase, TatD family'
WKK_03915	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
WKK_03925	COG1253	flavin adenine dinucleotide binding
WKK_03930	COG4466	Protein conserved in bacteria
WKK_03935	COG2131	deaminase
WKK_03940	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
WKK_03945	COG1316	TRANSCRIPTIONal
WKK_03960	COG1968	undecaprenyl-diphosphatase activity
WKK_03970	COG2235	arginine
WKK_03980	COG0531	amino acid
WKK_04005	COG0463	Glycosyl transferase, family 2
WKK_04015	COG0463	Glycosyl transferase, family 2
WKK_04020	COG1705	Flagellar rod assembly protein muramidase FlgJ
WKK_04025	COG2309	aminopeptidase activity
WKK_04035	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
WKK_04045	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
WKK_04050	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
WKK_04055	COG0252	asparaginase activity
WKK_04060	COG4443	Transcriptional Coactivator p15 (PC4)
WKK_04065	COG0745	RESPONSE REGULATOR receiver
WKK_04070	COG5002	protein histidine kinase activity
WKK_04080	COG0025	NhaP-type Na H and K H
WKK_04085	COG3118	belongs to the thioredoxin family
WKK_04100	COG0193	aminoacyl-tRNA hydrolase activity
WKK_04105	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
WKK_04110	COG2244	polysaccharide biosynthetic process
WKK_04115	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
WKK_04150	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
WKK_04155	COG1609	Transcriptional regulator
WKK_04165	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
WKK_04170	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
WKK_04180	COG1113	amino acid transport
WKK_04185	COG1737	Transcriptional regulator
WKK_04190	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
WKK_04205	COG4463	regulation of RNA biosynthetic process
WKK_04210	COG0542	response to heat
WKK_04215	COG0085	RNA polymerase activity
WKK_04220	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
WKK_04225	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
WKK_04240	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
WKK_04250	COG0813	purine-nucleoside phosphorylase activity
WKK_04270	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
WKK_04275	COG3590	peptidase
WKK_04280	COG1012	belongs to the aldehyde dehydrogenase family
WKK_04280	COG1454	alcohol dehydrogenase
WKK_04285	COG1252	NADH dehydrogenase
WKK_04290	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
WKK_04295	COG1122	ATPase activity
WKK_04300	COG1122	ATPase activity
WKK_04310	COG0101	tRNA pseudouridine synthase activity
WKK_04315	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
WKK_04330	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
WKK_04335	COG3870	Protein conserved in bacteria
WKK_04340	COG0470	DNA polymerase III
WKK_04355	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
WKK_04370	COG0667	Aldo Keto reductase
WKK_04375	COG1620	l-lactate permease
WKK_04380	COG0438	transferase activity, transferring glycosyl groups
WKK_04415	COG1063	alcohol dehydrogenase
WKK_04425	COG1811	Na channel or pump
WKK_04430	COG0583	DNA-binding transcription factor activity
WKK_04460	COG2207	Transcriptional regulator
WKK_04465	COG0534	Mate efflux family protein
WKK_04485	COG2115	Belongs to the xylose isomerase family
WKK_04510	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
WKK_04520	COG0531	amino acid
WKK_04530	COG1181	Belongs to the D-alanine--D-alanine ligase family
WKK_04535	COG1914	H( )-stimulated, divalent metal cation uptake system
WKK_04550	COG0391	Required for morphogenesis under gluconeogenic growth conditions
WKK_04555	COG1481	regulation of sporulation
WKK_04560	COG0740	serine-type endopeptidase activity
WKK_04575	COG0346	lactoylglutathione lyase activity
WKK_04605	COG0110	maltose O-acetyltransferase activity
WKK_04615	COG0542	response to heat
WKK_04625	COG0756	dUTP diphosphatase activity
WKK_04635	COG4956	integral membrane protein (PIN domain superfamily)
WKK_04645	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
WKK_04650	COG0072	phenylalanine-tRNA ligase activity
WKK_04650	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
WKK_04655	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
WKK_04665	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
WKK_04670	COG0768	penicillin binding
WKK_04675	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
WKK_04685	COG1940	carbohydrate kinase activity
WKK_04690	COG0791	NLP P60 protein
WKK_04710	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
WKK_04715	COG0789	Transcriptional regulator
WKK_04720	COG0174	glutamine synthetase
WKK_04740	COG0697	spore germination
WKK_04745	COG4708	membrane
WKK_04750	COG1028	Short-chain dehydrogenase reductase Sdr
WKK_04770	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
WKK_04780	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
WKK_04790	COG2252	PERMEase
WKK_04795	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
WKK_04810	COG2246	polysaccharide biosynthetic process
WKK_04815	COG0561	phosphatase activity
WKK_04820	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
WKK_04825	COG4589	Belongs to the CDS family
WKK_04830	COG0442	prolyl-tRNA aminoacylation
WKK_04840	COG2176	DNA-directed DNA polymerase activity
WKK_04845	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
WKK_04860	COG0006	proline dipeptidase activity
WKK_04875	COG4470	Protein conserved in bacteria
WKK_04880	COG0647	UMP catabolic process
WKK_04885	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
WKK_04890	COG0573	inorganic phosphate transmembrane transporter activity
WKK_04895	COG0581	inorganic phosphate transmembrane transporter activity
WKK_04905	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
WKK_04910	COG0704	Plays a role in the regulation of phosphate uptake
WKK_04920	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
WKK_04935	COG0557	exoribonuclease II activity
WKK_04940	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
WKK_04950	COG2153	protein acetylation
WKK_04965	COG1278	Cold shock
WKK_04980	COG2183	response to ionizing radiation
WKK_04995	COG2217	Heavy metal translocating P-type atpase
WKK_05005	COG0768	penicillin binding
WKK_05015	COG1051	belongs to the nudix hydrolase family
WKK_05025	COG2076	Multidrug Resistance protein
WKK_05030	COG1846	Transcriptional regulator
WKK_05035	COG0456	acetyltransferase
WKK_05045	COG2233	PERMEase
WKK_05055	COG0628	permease
WKK_05060	COG0402	S-adenosylhomocysteine deaminase activity
WKK_05065	COG0745	RESPONSE REGULATOR receiver
WKK_05070	COG2017	converts alpha-aldose to the beta-anomer
WKK_05075	COG0166	Belongs to the GPI family
WKK_05085	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
WKK_05090	COG1302	Protein conserved in bacteria
WKK_05100	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
WKK_05105	COG0291	Belongs to the bacterial ribosomal protein bL35 family
WKK_05110	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
WKK_05125	COG0049	tRNA binding
WKK_05130	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
WKK_05135	COG3842	ATPase activity
WKK_05140	COG0573	inorganic phosphate transmembrane transporter activity
WKK_05145	COG1177	transmembrane transport
WKK_05150	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
WKK_05155	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
WKK_05170	COG1950	PFAM Membrane protein of
WKK_05175	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
WKK_05180	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
WKK_05190	COG0492	ferredoxin-NADP+ reductase activity
WKK_05210	COG0149	triose-phosphate isomerase activity
WKK_05245	COG0126	phosphoglycerate kinase activity
WKK_05260	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
WKK_05270	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
WKK_05275	COG1713	HD superfamily hydrolase involved in NAD metabolism
WKK_05280	COG0799	negative regulation of ribosome biogenesis
WKK_05285	COG2226	methyltransferase
WKK_05290	COG1323	Belongs to the UPF0348 family
WKK_05300	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
WKK_05305	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
WKK_05310	COG0488	(ABC) transporter
WKK_05315	COG2137	regulation of response to DNA damage stimulus
WKK_05400	COG0582	viral genome integration into host DNA
WKK_05405	COG3557	Belongs to the UPF0374 family
WKK_05415	COG0436	Aminotransferase
WKK_05420	COG4684	Psort location CytoplasmicMembrane, score
WKK_05425	COG1970	mechanosensitive ion channel activity
WKK_05430	COG2759	Belongs to the formate--tetrahydrofolate ligase family
WKK_05435	COG1418	mRNA catabolic process
WKK_05440	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
WKK_05445	COG0459	protein refolding
WKK_05455	COG4720	Psort location CytoplasmicMembrane, score
WKK_05460	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
WKK_05465	COG4807	Protein conserved in bacteria
WKK_05470	COG0716	FMN binding
WKK_05475	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
WKK_05485	COG1122	ATPase activity
WKK_05495	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
WKK_05500	COG0667	Aldo Keto reductase
WKK_05505	COG0561	phosphatase activity
WKK_05510	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
WKK_05510	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
WKK_05515	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
WKK_05525	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
WKK_05530	COG1597	lipid kinase activity
WKK_05535	COG2706	6-phosphogluconolactonase activity
WKK_05540	COG0628	permease
WKK_05545	COG0586	Pfam SNARE associated Golgi protein
WKK_05550	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
WKK_05575	COG1705	Flagellar rod assembly protein muramidase FlgJ
WKK_05590	COG1278	Cold shock
WKK_05605	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
WKK_05610	COG0779	Required for maturation of 30S ribosomal subunits
WKK_05615	COG0195	Participates in both transcription termination and antitermination
WKK_05620	COG2740	Nucleic-acid-binding protein implicated in transcription termination
WKK_05630	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
WKK_05635	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
WKK_05640	COG1674	ftsk spoiiie
WKK_05670	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
WKK_05680	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
WKK_05685	COG0218	Necessary for normal cell division and for the maintenance of normal septation
WKK_05700	COG1193	negative regulation of DNA recombination
WKK_05705	COG0656	L-ascorbic acid biosynthetic process
WKK_05710	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
WKK_05715	COG3425	synthase
WKK_05725	COG0860	N-Acetylmuramoyl-L-alanine amidase
WKK_05730	COG0124	histidyl-tRNA synthetase
WKK_05735	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
WKK_05740	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
WKK_05745	COG0828	Belongs to the bacterial ribosomal protein bS21 family
WKK_05750	COG1610	YqeY-like protein
WKK_05755	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
WKK_05760	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
WKK_05765	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
WKK_05770	COG1381	Involved in DNA repair and RecF pathway recombination
WKK_05780	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
WKK_05785	COG0196	riboflavin kinase activity
WKK_05795	COG1134	teichoic acid transport
WKK_05795	COG1388	LysM domain
WKK_05800	COG1682	transport, permease protein
WKK_05815	COG2610	gluconate transmembrane transporter activity
WKK_05820	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
WKK_05825	COG0612	Peptidase, M16
WKK_05830	COG0612	Peptidase, M16
WKK_05835	COG1426	Protein conserved in bacteria
WKK_05840	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
WKK_05845	COG1546	Belongs to the CinA family
WKK_05845	COG1058	Belongs to the CinA family
WKK_05850	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
WKK_05865	COG0024	Methionine aminopeptidase
WKK_05870	COG1719	4-vinyl reductase, 4VR
WKK_05880	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
WKK_05885	COG1234	tRNA 3'-trailer cleavage
WKK_05890	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
WKK_05890	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
WKK_05900	COG4224	UPF0291 protein
WKK_05905	COG3763	UPF0154 protein
WKK_05910	COG0204	Acyl-transferase
WKK_05915	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
WKK_05920	COG2827	Endonuclease containing a URI domain
WKK_05925	COG0052	Belongs to the universal ribosomal protein uS2 family
WKK_05930	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
WKK_05935	COG0528	UMP kinase activity
WKK_05945	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
WKK_05950	COG1428	Deoxynucleoside kinase
WKK_05955	COG0546	phosphoglycolate phosphatase activity
WKK_05965	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
WKK_05980	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
WKK_05995	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
WKK_06005	COG0617	tRNA 3'-terminal CCA addition
WKK_06010	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
WKK_06030	COG4862	establishment of competence for transformation
WKK_06040	COG1164	Oligoendopeptidase f
WKK_06045	COG0752	glycyl-tRNA synthetase alpha subunit
WKK_06050	COG0751	glycine-tRNA ligase activity
WKK_06065	COG2814	Major facilitator Superfamily
WKK_06075	COG0765	amino acid transport
WKK_06080	COG1126	abc transporter atp-binding protein
WKK_06085	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WKK_06090	COG2814	Major facilitator Superfamily
WKK_06100	COG3331	DNA recombination
WKK_06105	COG4474	Belongs to the UPF0398 family
WKK_06115	COG0116	Belongs to the methyltransferase superfamily
WKK_06125	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
WKK_06145	COG1132	(ABC) transporter
WKK_06150	COG0556	nucleotide-excision repair
WKK_06160	COG0564	pseudouridine synthase activity
WKK_06165	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
WKK_06170	COG0505	Belongs to the CarA family
WKK_06180	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
WKK_06205	COG1304	FMN binding
WKK_06225	COG1199	ATP-dependent helicase activity
WKK_06225	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
WKK_06235	COG0017	Asparaginyl-tRNA synthetase
WKK_06240	COG0488	(ABC) transporter
WKK_06255	COG0587	DNA-directed DNA polymerase activity
WKK_06260	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
WKK_06270	COG2996	Protein conserved in bacteria
WKK_06280	COG1187	pseudouridine synthase activity
WKK_06290	COG0514	ATP-dependent DNA helicase (RecQ)
WKK_06300	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
WKK_06305	COG0539	negative regulation of cytoplasmic translation
WKK_06310	COG1160	GTP binding
WKK_06320	COG4975	Glucose uptake
WKK_06325	COG0561	phosphatase activity
WKK_06330	COG0095	Lipoate-protein ligase
WKK_06360	COG1316	TRANSCRIPTIONal
WKK_06370	COG0489	protein tyrosine kinase activity
WKK_06375	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
WKK_06390	COG0583	DNA-binding transcription factor activity
WKK_06395	COG2855	membrane
WKK_06400	COG2199	diguanylate cyclase activity
WKK_06405	COG0791	NLP P60 protein
WKK_06405	COG3883	PFAM NLP P60 protein
WKK_06410	COG0393	Putative heavy-metal-binding
WKK_06420	COG0358	DNA primase activity
WKK_06425	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
WKK_06430	COG1420	regulation of RNA biosynthetic process
WKK_06440	COG0443	Heat shock 70 kDa protein
WKK_06445	COG0484	heat shock protein binding
WKK_06460	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
WKK_06465	COG2211	Major facilitator Superfamily
WKK_06470	COG0745	RESPONSE REGULATOR receiver
WKK_06475	COG5002	protein histidine kinase activity
WKK_06480	COG0572	uridine kinase
WKK_06485	COG1363	Peptidase, m42
WKK_06490	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
WKK_06490	COG0072	phenylalanine-tRNA ligase activity
WKK_06505	COG0670	Belongs to the BI1 family
WKK_06535	COG3706	GGDEF domain
WKK_06540	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
WKK_06545	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
WKK_06560	COG1215	transferase activity, transferring glycosyl groups
WKK_06575	COG0583	DNA-binding transcription factor activity
WKK_06595	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
WKK_06615	COG0653	protein targeting
WKK_06630	COG1073	alpha beta
WKK_06655	COG0346	lactoylglutathione lyase activity
WKK_06852	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
WKK_06887	COG2217	Heavy metal translocating P-type atpase
WKK_06897	COG0640	Transcriptional regulator
WKK_06907	COG3118	belongs to the thioredoxin family
WKK_06912	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
WKK_06917	COG0492	ferredoxin-NADP+ reductase activity
WKK_06932	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
WKK_06957	COG0604	alcohol dehydrogenase