locus-tag	class	description
FY536_00115	COG1181	Belongs to the D-alanine--D-alanine ligase family
FY536_00115	COG2918	glutathione biosynthetic process
FY536_00145	COG1073	alpha beta
FY536_00155	COG0653	protein targeting
FY536_00160	COG0028	Belongs to the TPP enzyme family
FY536_00165	COG1695	Transcriptional regulator
FY536_00170	COG3479	Phenolic acid decarboxylase
FY536_00175	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FY536_00215	COG0653	protein targeting
FY536_00230	COG0438	transferase activity, transferring glycosyl groups
FY536_00235	COG2233	PERMEase
FY536_00240	COG2217	Heavy metal translocating P-type atpase
FY536_00255	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FY536_00260	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FY536_00265	COG1288	antiporter activity
FY536_00270	COG0477	Major facilitator Superfamily
FY536_00275	COG0481	GTPase activity
FY536_00285	COG1309	transcriptional regulator
FY536_00310	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
FY536_00315	COG0267	Belongs to the bacterial ribosomal protein bL33 family
FY536_00325	COG2195	Cleaves the N-terminal amino acid of tripeptides
FY536_00330	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
FY536_00335	COG2384	SAM-dependent methyltransferase
FY536_00355	COG2807	transmembrane transport
FY536_00360	COG4720	Psort location CytoplasmicMembrane, score
FY536_00365	COG0351	phosphomethylpyrimidine kinase
FY536_00370	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FY536_00370	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FY536_00375	COG1668	transmembrane transport
FY536_00380	COG4152	abc transporter atp-binding protein
FY536_00390	COG0604	alcohol dehydrogenase
FY536_00395	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FY536_00400	COG0516	GMP reductase activity
FY536_00405	COG0706	membrane insertase activity
FY536_00415	COG0765	amino acid transport
FY536_00420	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FY536_00430	COG3480	Lon protease (S16) C-terminal proteolytic domain
FY536_00435	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
FY536_00440	COG0742	ribosomal rna small subunit methyltransferase
FY536_00445	COG4471	UPF0298 protein
FY536_00450	COG0772	Belongs to the SEDS family
FY536_00455	COG1217	gtp-binding protein TYPA
FY536_00460	COG0483	inositol monophosphate 1-phosphatase activity
FY536_00470	COG0242	peptide deformylase activity
FY536_00480	COG1876	peptidase activity
FY536_00495	COG1597	lipid kinase activity
FY536_00500	COG1227	inorganic diphosphatase activity
FY536_00510	COG0187	DNA topoisomerase II activity
FY536_00515	COG1739	Uncharacterized protein family UPF0029
FY536_00525	COG0322	excinuclease ABC activity
FY536_00530	COG0406	alpha-ribazole phosphatase activity
FY536_00535	COG0336	Belongs to the RNA methyltransferase TrmD family
FY536_00555	COG0477	Major facilitator Superfamily
FY536_00560	COG0228	four-way junction DNA binding
FY536_00565	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
FY536_00570	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
FY536_00575	COG0552	protein localization to endoplasmic reticulum
FY536_00580	COG0571	ribonuclease III activity
FY536_00585	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FY536_00590	COG0416	fatty acid biosynthetic process
FY536_00595	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
FY536_00600	COG2252	PERMEase
FY536_00605	COG0018	arginyl-trna synthetase
FY536_00625	COG0501	Belongs to the peptidase M48B family
FY536_00630	COG1704	LemA family
FY536_00635	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FY536_00640	COG1461	Dihydroxyacetone kinase
FY536_00650	COG0227	Belongs to the bacterial ribosomal protein bL28 family
FY536_00655	COG1564	THIamine pyrophosphokinase
FY536_00660	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
FY536_00665	COG1162	GTPase activity
FY536_00670	COG0515	serine threonine protein kinase
FY536_00670	COG2815	serine threonine protein kinase
FY536_00675	COG0631	protein serine/threonine phosphatase activity
FY536_00680	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FY536_00680	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
FY536_00685	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
FY536_00690	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
FY536_00695	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
FY536_00725	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
FY536_00740	COG1942	4-Oxalocrotonate Tautomerase
FY536_00745	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
FY536_00750	COG0513	Belongs to the DEAD box helicase family
FY536_00755	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
FY536_00760	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
FY536_00765	COG1862	Preprotein translocase
FY536_00770	COG0343	queuine tRNA-ribosyltransferase activity
FY536_00775	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
FY536_00780	COG2255	four-way junction helicase activity
FY536_00785	COG0632	four-way junction helicase activity
FY536_00790	COG1757	Na H antiporter
FY536_00795	COG0758	DNA mediated transformation
FY536_00800	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
FY536_00810	COG4479	Belongs to the UPF0346 family
FY536_00825	COG1307	EDD domain protein, DegV family
FY536_00830	COG1307	EDD domain protein, DegV family
FY536_00840	COG0446	pyridine nucleotide-disulphide oxidoreductase
FY536_00845	COG5002	protein histidine kinase activity
FY536_00850	COG0745	RESPONSE REGULATOR receiver
FY536_00865	COG1484	DNA-dependent DNA replication
FY536_00880	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
FY536_00890	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FY536_00895	COG0220	tRNA (guanine-N7-)-methyltransferase activity
FY536_00900	COG0537	adenosine 5'-monophosphoramidase activity
FY536_00910	COG3759	membrane
FY536_00915	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
FY536_00930	COG4221	oxidoreductase activity
FY536_00935	COG0583	DNA-binding transcription factor activity
FY536_00940	COG2261	transglycosylase associated protein
FY536_00970	COG3237	CsbD-like
FY536_00985	COG2261	transglycosylase associated protein
FY536_00995	COG1461	Dihydroxyacetone kinase
FY536_01000	COG1942	4-Oxalocrotonate Tautomerase
FY536_01010	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FY536_01015	COG2226	methyltransferase
FY536_01110	COG0582	viral genome integration into host DNA
FY536_01120	COG1609	Transcriptional regulator
FY536_01125	COG0006	proline dipeptidase activity
FY536_01130	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FY536_01135	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FY536_01150	COG1846	Transcriptional regulator
FY536_01155	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
FY536_01160	COG3599	regulation of cell shape
FY536_01175	COG1799	cell septum assembly
FY536_01190	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
FY536_01195	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
FY536_01200	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
FY536_01205	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FY536_01210	COG0768	penicillin binding
FY536_01220	COG0275	rRNA processing
FY536_01225	COG2001	Belongs to the MraZ family
FY536_01235	COG1385	rRNA (uridine-N3-)-methyltransferase activity
FY536_01240	COG2264	protein methyltransferase activity
FY536_01245	COG0833	amino acid
FY536_01265	COG1077	Cell shape determining protein MreB Mrl
FY536_01270	COG2003	Belongs to the UPF0758 family
FY536_01305	COG0561	phosphatase activity
FY536_01310	COG0363	glucosamine-6-phosphate deaminase activity
FY536_01315	COG2207	Transcriptional regulator
FY536_01325	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
FY536_01370	COG0335	large ribosomal subunit rRNA binding
FY536_01380	COG3481	metal-dependent phosphohydrolase, HD sub domain
FY536_01385	COG4717	serine-type aminopeptidase activity
FY536_01390	COG0420	3'-5' exonuclease activity
FY536_01395	COG3679	Belongs to the UPF0342 family
FY536_01400	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FY536_01405	COG1438	arginine binding
FY536_01415	COG1136	(ABC) transporter
FY536_01420	COG0268	Binds directly to 16S ribosomal RNA
FY536_01425	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
FY536_01430	COG1466	dna polymerase III delta subunit
FY536_01435	COG2333	competence protein COMEC
FY536_01435	COG0658	competence protein
FY536_01440	COG1596	polysaccharide export
FY536_01440	COG1555	photosystem II stabilization
FY536_01460	COG3906	Belongs to the UPF0473 family
FY536_01465	COG3906	Belongs to the UPF0473 family
FY536_01475	COG4472	Bacterial protein of unknown function (DUF965)
FY536_01480	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
FY536_01485	COG2814	Major facilitator Superfamily
FY536_01490	COG2239	Acts as a magnesium transporter
FY536_01495	COG0564	pseudouridine synthase activity
FY536_01500	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
FY536_01505	COG2357	RelA SpoT domain protein
FY536_01510	COG0562	UDP-galactopyranose mutase
FY536_01525	COG1758	RNA polymerase activity
FY536_01530	COG0194	GDP metabolic process
FY536_01535	COG0497	DNA recombination
FY536_01540	COG1438	arginine binding
FY536_01545	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
FY536_01550	COG0142	geranyltranstransferase activity
FY536_01555	COG1722	exodeoxyribonuclease VII activity
FY536_01565	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
FY536_01570	COG0513	Belongs to the DEAD box helicase family
FY536_01575	COG0673	inositol 2-dehydrogenase activity
FY536_01580	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
FY536_01590	COG0525	valine-tRNA ligase activity
FY536_01610	COG4175	Glycine betaine
FY536_01610	COG3448	diguanylate cyclase activity
FY536_01615	COG0589	response to stress
FY536_01635	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
FY536_01640	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
FY536_01650	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FY536_01655	COG2084	Dehydrogenase
FY536_01660	COG0656	L-ascorbic acid biosynthetic process
FY536_01670	COG2160	L-arabinose isomerase activity
FY536_01685	COG2211	Major facilitator Superfamily
FY536_01690	COG3940	Belongs to the glycosyl hydrolase 43 family
FY536_01695	COG1609	Transcriptional regulator
FY536_01700	COG3706	GGDEF domain
FY536_01725	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
FY536_01730	COG4120	Belongs to the binding-protein-dependent transport system permease family
FY536_01740	COG4720	Psort location CytoplasmicMembrane, score
FY536_01750	COG2814	Major facilitator Superfamily
FY536_01760	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
FY536_01770	COG1230	cation diffusion facilitator family transporter
FY536_01775	COG0741	lytic transglycosylase activity
FY536_01780	COG1072	(Pantothenic acid kinase))
FY536_01785	COG3973	AAA domain
FY536_01795	COG3716	PTS system mannose fructose sorbose family IID component
FY536_01800	COG3715	PTS system
FY536_01860	COG3583	domain protein
FY536_01860	COG3525	Glycosyl hydrolase, family 20, catalytic domain
FY536_01860	COG3064	Membrane
FY536_01910	COG1368	sulfuric ester hydrolase activity
FY536_01925	COG0438	transferase activity, transferring glycosyl groups
FY536_01930	COG0438	transferase activity, transferring glycosyl groups
FY536_01940	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FY536_01945	COG4856	YbbR-like protein
FY536_01960	COG0812	UDP-N-acetylmuramate dehydrogenase activity
FY536_01975	COG0802	atpase or kinase
FY536_01980	COG0280	phosphate acetyltransferase
FY536_01985	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
FY536_01995	COG1983	PspC domain protein
FY536_02010	COG0735	belongs to the Fur family
FY536_02020	COG2070	2-Nitropropane dioxygenase
FY536_02030	COG1929	Belongs to the glycerate kinase type-1 family
FY536_02035	COG0024	Methionine aminopeptidase
FY536_02065	COG0464	growth
FY536_02085	COG0789	Transcriptional regulator
FY536_02090	COG0656	L-ascorbic acid biosynthetic process
FY536_02115	COG0577	efflux transmembrane transporter activity
FY536_02135	COG0211	Belongs to the bacterial ribosomal protein bL27 family
FY536_02140	COG0261	This protein binds to 23S rRNA in the presence of protein L20
FY536_02145	COG0305	Participates in initiation and elongation during chromosome replication
FY536_02150	COG0359	binds to the 23S rRNA
FY536_02160	COG0765	amino acid transport
FY536_02165	COG0765	amino acid transport
FY536_02170	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FY536_02180	COG0194	GDP metabolic process
FY536_02190	COG0577	efflux transmembrane transporter activity
FY536_02190	COG1136	(ABC) transporter
FY536_02195	COG1132	(ABC) transporter
FY536_02200	COG1132	(ABC) transporter
FY536_02205	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
FY536_02210	COG0588	phosphoglycerate mutase activity
FY536_02220	COG0708	Exodeoxyribonuclease III
FY536_02240	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
FY536_02245	COG0772	Belongs to the SEDS family
FY536_02255	COG1077	Cell shape determining protein MreB Mrl
FY536_02260	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
FY536_02265	COG0737	Belongs to the 5'-nucleotidase family
FY536_02275	COG0352	thiamine-phosphate diphosphorylase activity
FY536_02280	COG0351	phosphomethylpyrimidine kinase
FY536_02285	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
FY536_02290	COG1511	domain protein
FY536_02300	COG3250	beta-galactosidase activity
FY536_02310	COG0588	phosphoglycerate mutase activity
FY536_02315	COG0492	ferredoxin-NADP+ reductase activity
FY536_02330	COG0596	Alpha beta hydrolase
FY536_02335	COG1733	regulation of RNA biosynthetic process
FY536_02345	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FY536_02355	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
FY536_02360	COG0653	protein targeting
FY536_02365	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
FY536_02380	COG2337	Toxic component of a toxin-antitoxin (TA) module
FY536_02395	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
FY536_02400	COG0504	CTP synthase activity
FY536_02410	COG1091	dTDP-4-dehydrorhamnose reductase activity
FY536_02415	COG1088	dTDP-glucose 4,6-dehydratase activity
FY536_02425	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
FY536_02430	COG1215	transferase activity, transferring glycosyl groups
FY536_02455	COG0438	transferase activity, transferring glycosyl groups
FY536_02460	COG0438	transferase activity, transferring glycosyl groups
FY536_02465	COG1078	dGTPase activity
FY536_02475	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FY536_02480	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
FY536_02495	COG5002	protein histidine kinase activity
FY536_02500	COG0745	RESPONSE REGULATOR receiver
FY536_02505	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
FY536_02510	COG0629	single-stranded DNA binding
FY536_02515	COG0360	Binds together with S18 to 16S ribosomal RNA
FY536_02520	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
FY536_02525	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
FY536_02530	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
FY536_02535	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
FY536_02545	COG1074	ATP-dependent DNA helicase activity
FY536_02550	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
FY536_02560	COG2813	Specifically methylates the guanine in position
FY536_02565	COG0582	viral genome integration into host DNA
FY536_02600	COG1064	alcohol dehydrogenase
FY536_02605	COG0203	ribosomal protein L17
FY536_02610	COG0202	RNA polymerase activity
FY536_02615	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
FY536_02620	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
FY536_02630	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
FY536_02635	COG0563	adenylate kinase activity
FY536_02645	COG0200	Binds to the 23S rRNA
FY536_02650	COG1841	ribosomal large subunit assembly
FY536_02655	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
FY536_02660	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
FY536_02665	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
FY536_02670	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
FY536_02675	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
FY536_02680	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
FY536_02685	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
FY536_02695	COG0255	Belongs to the universal ribosomal protein uL29 family
FY536_02700	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
FY536_02705	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
FY536_02710	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
FY536_02715	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
FY536_02720	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
FY536_02725	COG0089	rRNA binding
FY536_02735	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
FY536_02740	COG0051	transcription antitermination factor activity, RNA binding
FY536_02765	COG0438	transferase activity, transferring glycosyl groups
FY536_02775	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
FY536_02780	COG2244	polysaccharide biosynthetic process
FY536_02800	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
FY536_02815	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
FY536_02825	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
FY536_02830	COG0456	acetyltransferase
FY536_02840	COG1214	PFAM Peptidase M22, glycoprotease
FY536_02870	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
FY536_02875	COG1428	Deoxynucleoside kinase
FY536_02880	COG0355	proton-transporting ATP synthase activity, rotational mechanism
FY536_02885	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
FY536_02890	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
FY536_02895	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
FY536_02905	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
FY536_02910	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FY536_02915	COG0356	it plays a direct role in the translocation of protons across the membrane
FY536_02920	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
FY536_02925	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
FY536_02930	COG0009	L-threonylcarbamoyladenylate synthase
FY536_02935	COG2890	protein-(glutamine-N5) methyltransferase activity
FY536_02945	COG1435	thymidine kinase activity
FY536_02950	COG3442	glutamine amidotransferase
FY536_02955	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
FY536_02965	COG0531	amino acid
FY536_02980	COG0500	methyltransferase
FY536_02985	COG0531	amino acid
FY536_02990	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
FY536_03000	COG2244	polysaccharide biosynthetic process
FY536_03015	COG0495	leucyl-tRNA aminoacylation
FY536_03020	COG0671	phosphoesterase, PA-phosphatase related
FY536_03030	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
FY536_03035	COG1114	Component of the transport system for branched-chain amino acids
FY536_03050	COG0531	amino acid
FY536_03065	COG1957	nucleoside hydrolase
FY536_03070	COG1136	(ABC) transporter
FY536_03075	COG0577	efflux transmembrane transporter activity
FY536_03080	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
FY536_03085	COG0784	Response regulator, receiver
FY536_03090	COG4251	negative regulation of phosphorylation
FY536_03095	COG1288	antiporter activity
FY536_03105	COG1869	D-ribose catabolic process
FY536_03115	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
FY536_03155	COG1522	sequence-specific DNA binding
FY536_03165	COG0222	ribosome binding
FY536_03170	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
FY536_03175	COG0081	regulation of translation
FY536_03180	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
FY536_03205	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FY536_03210	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
FY536_03215	COG0215	cysteine-tRNA ligase activity
FY536_03220	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
FY536_03225	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
FY536_03240	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
FY536_03255	COG1482	cell wall glycoprotein biosynthetic process
FY536_03270	COG1272	protein, Hemolysin III
FY536_03275	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
FY536_03280	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
FY536_03285	COG2188	Transcriptional regulator
FY536_03290	COG2814	Major facilitator Superfamily
FY536_03315	COG0488	(ABC) transporter
FY536_03320	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FY536_03325	COG1121	(ABC) transporter
FY536_03340	COG2755	lipolytic protein G-D-S-L family
FY536_03340	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
FY536_03350	COG3104	oligopeptide transport
FY536_03360	COG0300	oxidoreductase activity
FY536_03380	COG5002	protein histidine kinase activity
FY536_03395	COG0012	GTP binding
FY536_03400	COG4481	Protein conserved in bacteria
FY536_03405	COG1475	DNA binding
FY536_03410	COG1192	Involved in chromosome partitioning
FY536_03415	COG0357	Ribosomal RNA small subunit methyltransferase G
FY536_03420	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FY536_03430	COG0657	acetylesterase activity
FY536_03440	COG0628	permease
FY536_03445	COG1254	Belongs to the acylphosphatase family
FY536_03450	COG1881	PFAM PEBP family protein
FY536_03460	COG4221	oxidoreductase activity
FY536_03465	COG0789	Transcriptional regulator
FY536_03470	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
FY536_03475	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
FY536_03495	COG1959	2 iron, 2 sulfur cluster binding
FY536_03505	COG0477	Major facilitator Superfamily
FY536_03515	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FY536_03530	COG0702	epimerase
FY536_03535	COG0667	Aldo Keto reductase
FY536_03540	COG0586	Pfam SNARE associated Golgi protein
FY536_03550	COG0328	RNA-DNA hybrid ribonuclease activity
FY536_03555	COG0561	phosphatase activity
FY536_03560	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FY536_03565	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
FY536_03600	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
FY536_03630	COG3104	oligopeptide transport
FY536_03660	COG0492	ferredoxin-NADP+ reductase activity
FY536_03665	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FY536_03670	COG3118	belongs to the thioredoxin family
FY536_03685	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FY536_03715	COG0656	L-ascorbic acid biosynthetic process
FY536_03725	COG0583	DNA-binding transcription factor activity
FY536_03745	COG0604	alcohol dehydrogenase
FY536_03750	COG1902	pentaerythritol trinitrate reductase activity
FY536_03760	COG0789	Transcriptional regulator
FY536_03765	COG0583	DNA-binding transcription factor activity
FY536_03775	COG1285	pathogenesis
FY536_03790	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
FY536_03870	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
FY536_03880	COG0583	DNA-binding transcription factor activity
FY536_03885	COG1442	glycosyl transferase family 8
FY536_03890	COG0569	domain protein
FY536_03895	COG1113	amino acid transport
FY536_03905	COG0706	membrane insertase activity
FY536_03910	COG0594	ribonuclease P activity
FY536_03915	COG0230	Belongs to the bacterial ribosomal protein bL34 family
FY536_03920	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
FY536_03925	COG0592	DNA-directed DNA polymerase activity
FY536_03930	COG2501	S4 domain
FY536_03935	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
FY536_03940	COG0187	DNA topoisomerase II activity
FY536_03950	COG1368	sulfuric ester hydrolase activity
FY536_03990	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FY536_03990	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FY536_03995	COG0084	hydrolase, TatD family'
FY536_04000	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
FY536_04010	COG1253	flavin adenine dinucleotide binding
FY536_04015	COG4466	Protein conserved in bacteria
FY536_04020	COG2131	deaminase
FY536_04025	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
FY536_04030	COG1316	TRANSCRIPTIONal
FY536_04045	COG1968	undecaprenyl-diphosphatase activity
FY536_04055	COG2235	arginine
FY536_04065	COG0531	amino acid
FY536_04090	COG0463	Glycosyl transferase, family 2
FY536_04100	COG0463	Glycosyl transferase, family 2
FY536_04110	COG1388	LysM domain
FY536_04110	COG1705	Flagellar rod assembly protein muramidase FlgJ
FY536_04120	COG2309	aminopeptidase activity
FY536_04130	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
FY536_04140	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
FY536_04145	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
FY536_04150	COG0252	asparaginase activity
FY536_04155	COG4443	Transcriptional Coactivator p15 (PC4)
FY536_04160	COG0745	RESPONSE REGULATOR receiver
FY536_04165	COG5002	protein histidine kinase activity
FY536_04175	COG0025	NhaP-type Na H and K H
FY536_04180	COG3118	belongs to the thioredoxin family
FY536_04195	COG0193	aminoacyl-tRNA hydrolase activity
FY536_04200	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
FY536_04205	COG2244	polysaccharide biosynthetic process
FY536_04210	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
FY536_04245	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
FY536_04250	COG1609	Transcriptional regulator
FY536_04260	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
FY536_04265	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
FY536_04305	COG1113	amino acid transport
FY536_04310	COG1737	Transcriptional regulator
FY536_04315	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
FY536_04345	COG4463	regulation of RNA biosynthetic process
FY536_04350	COG0542	response to heat
FY536_04355	COG0085	RNA polymerase activity
FY536_04360	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
FY536_04365	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
FY536_04380	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
FY536_04390	COG0813	purine-nucleoside phosphorylase activity
FY536_04410	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
FY536_04415	COG3590	peptidase
FY536_04420	COG1454	alcohol dehydrogenase
FY536_04420	COG1012	belongs to the aldehyde dehydrogenase family
FY536_04425	COG1252	NADH dehydrogenase
FY536_04435	COG1122	ATPase activity
FY536_04440	COG1122	ATPase activity
FY536_04450	COG0101	tRNA pseudouridine synthase activity
FY536_04460	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
FY536_04475	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
FY536_04480	COG3870	Protein conserved in bacteria
FY536_04485	COG0470	DNA polymerase III
FY536_04500	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
FY536_04515	COG0667	Aldo Keto reductase
FY536_04520	COG1620	l-lactate permease
FY536_04525	COG0438	transferase activity, transferring glycosyl groups
FY536_04590	COG1063	alcohol dehydrogenase
FY536_04600	COG1811	Na channel or pump
FY536_04605	COG0583	DNA-binding transcription factor activity
FY536_04625	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FY536_04630	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FY536_04635	COG1070	Carbohydrate kinase
FY536_04640	COG1802	Transcriptional regulator
FY536_04645	COG0246	Mannitol dehydrogenase
FY536_04650	COG1312	Catalyzes the dehydration of D-mannonate
FY536_04655	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
FY536_04665	COG2211	Major facilitator Superfamily
FY536_04675	COG1904	glucuronate isomerase
FY536_04690	COG2207	Transcriptional regulator
FY536_04695	COG0534	Mate efflux family protein
FY536_04710	COG2115	Belongs to the xylose isomerase family
FY536_04735	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
FY536_04745	COG0531	amino acid
FY536_04755	COG1181	Belongs to the D-alanine--D-alanine ligase family
FY536_04760	COG1914	H( )-stimulated, divalent metal cation uptake system
FY536_04775	COG0391	Required for morphogenesis under gluconeogenic growth conditions
FY536_04780	COG1481	regulation of sporulation
FY536_04785	COG0740	serine-type endopeptidase activity
FY536_04800	COG0346	lactoylglutathione lyase activity
FY536_04830	COG0110	maltose O-acetyltransferase activity
FY536_04840	COG0542	response to heat
FY536_04850	COG0756	dUTP diphosphatase activity
FY536_04860	COG4956	integral membrane protein (PIN domain superfamily)
FY536_04870	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
FY536_04875	COG0072	phenylalanine-tRNA ligase activity
FY536_04875	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FY536_04880	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
FY536_04890	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FY536_04895	COG0768	penicillin binding
FY536_04900	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
FY536_04910	COG1940	carbohydrate kinase activity
FY536_04915	COG0791	NLP P60 protein
FY536_04935	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
FY536_04940	COG0789	Transcriptional regulator
FY536_04945	COG0174	glutamine synthetase
FY536_04965	COG0697	spore germination
FY536_04970	COG4708	membrane
FY536_05000	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
FY536_05005	COG2188	Transcriptional regulator
FY536_05010	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
FY536_05020	COG2252	PERMEase
FY536_05025	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
FY536_05030	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
FY536_05040	COG2246	polysaccharide biosynthetic process
FY536_05045	COG0561	phosphatase activity
FY536_05050	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
FY536_05055	COG4589	Belongs to the CDS family
FY536_05060	COG0442	prolyl-tRNA aminoacylation
FY536_05070	COG2176	DNA-directed DNA polymerase activity
FY536_05095	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
FY536_05110	COG0006	proline dipeptidase activity
FY536_05125	COG4470	Protein conserved in bacteria
FY536_05130	COG0647	UMP catabolic process
FY536_05140	COG0573	inorganic phosphate transmembrane transporter activity
FY536_05145	COG0581	inorganic phosphate transmembrane transporter activity
FY536_05155	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
FY536_05160	COG0704	Plays a role in the regulation of phosphate uptake
FY536_05170	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
FY536_05185	COG0557	exoribonuclease II activity
FY536_05190	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
FY536_05195	COG3104	oligopeptide transport
FY536_05200	COG2153	protein acetylation
FY536_05210	COG1278	Cold shock
FY536_05225	COG2183	response to ionizing radiation
FY536_05250	COG2217	Heavy metal translocating P-type atpase
FY536_05260	COG0768	penicillin binding
FY536_05275	COG1051	belongs to the nudix hydrolase family
FY536_05285	COG2076	Multidrug Resistance protein
FY536_05290	COG1846	Transcriptional regulator
FY536_05295	COG0456	acetyltransferase
FY536_05305	COG2233	PERMEase
FY536_05315	COG0628	permease
FY536_05320	COG0402	S-adenosylhomocysteine deaminase activity
FY536_05325	COG0745	RESPONSE REGULATOR receiver
FY536_05330	COG2017	converts alpha-aldose to the beta-anomer
FY536_05335	COG0166	Belongs to the GPI family
FY536_05345	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
FY536_05350	COG1302	Protein conserved in bacteria
FY536_05360	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
FY536_05365	COG0291	Belongs to the bacterial ribosomal protein bL35 family
FY536_05370	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
FY536_05385	COG0049	tRNA binding
FY536_05390	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
FY536_05395	COG3842	ATPase activity
FY536_05400	COG0573	inorganic phosphate transmembrane transporter activity
FY536_05405	COG1177	transmembrane transport
FY536_05410	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
FY536_05415	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
FY536_05425	COG2814	Major facilitator Superfamily
FY536_05435	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
FY536_05440	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
FY536_05445	COG1210	Utp--glucose-1-phosphate uridylyltransferase
FY536_05450	COG0492	ferredoxin-NADP+ reductase activity
FY536_05470	COG0149	triose-phosphate isomerase activity
FY536_05510	COG0126	phosphoglycerate kinase activity
FY536_05525	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
FY536_05535	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
FY536_05540	COG1713	HD superfamily hydrolase involved in NAD metabolism
FY536_05545	COG0799	negative regulation of ribosome biogenesis
FY536_05550	COG2226	methyltransferase
FY536_05555	COG1323	Belongs to the UPF0348 family
FY536_05565	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
FY536_05570	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
FY536_05575	COG0488	(ABC) transporter
FY536_05580	COG2137	regulation of response to DNA damage stimulus
FY536_05650	COG0582	viral genome integration into host DNA
FY536_05655	COG3557	Belongs to the UPF0374 family
FY536_05665	COG0436	Aminotransferase
FY536_05670	COG4684	Psort location CytoplasmicMembrane, score
FY536_05675	COG1970	mechanosensitive ion channel activity
FY536_05680	COG2759	Belongs to the formate--tetrahydrofolate ligase family
FY536_05685	COG1418	mRNA catabolic process
FY536_05690	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
FY536_05695	COG0459	protein refolding
FY536_05705	COG4720	Psort location CytoplasmicMembrane, score
FY536_05710	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
FY536_05715	COG4807	Protein conserved in bacteria
FY536_05720	COG0716	FMN binding
FY536_05725	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
FY536_05735	COG1122	ATPase activity
FY536_05745	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
FY536_05750	COG0667	Aldo Keto reductase
FY536_05755	COG0561	phosphatase activity
FY536_05765	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FY536_05775	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FY536_05780	COG1597	lipid kinase activity
FY536_05790	COG2706	6-phosphogluconolactonase activity
FY536_05795	COG0628	permease
FY536_05800	COG0586	Pfam SNARE associated Golgi protein
FY536_05805	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
FY536_05920	COG1705	Flagellar rod assembly protein muramidase FlgJ
FY536_05940	COG1278	Cold shock
FY536_05955	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
FY536_05960	COG0779	Required for maturation of 30S ribosomal subunits
FY536_05965	COG0195	Participates in both transcription termination and antitermination
FY536_05970	COG2740	Nucleic-acid-binding protein implicated in transcription termination
FY536_05980	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
FY536_05985	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
FY536_05990	COG1674	ftsk spoiiie
FY536_06020	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FY536_06030	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
FY536_06035	COG0218	Necessary for normal cell division and for the maintenance of normal septation
FY536_06050	COG1193	negative regulation of DNA recombination
FY536_06055	COG0656	L-ascorbic acid biosynthetic process
FY536_06065	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
FY536_06070	COG3425	synthase
FY536_06080	COG0860	N-Acetylmuramoyl-L-alanine amidase
FY536_06085	COG0124	histidyl-tRNA synthetase
FY536_06090	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
FY536_06095	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
FY536_06100	COG0828	Belongs to the bacterial ribosomal protein bS21 family
FY536_06105	COG1610	YqeY-like protein
FY536_06110	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
FY536_06115	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
FY536_06120	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
FY536_06125	COG1381	Involved in DNA repair and RecF pathway recombination
FY536_06135	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
FY536_06140	COG0196	riboflavin kinase activity
FY536_06150	COG1134	teichoic acid transport
FY536_06150	COG1388	LysM domain
FY536_06155	COG1682	transport, permease protein
FY536_06170	COG2610	gluconate transmembrane transporter activity
FY536_06175	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FY536_06180	COG0612	Peptidase, M16
FY536_06185	COG0612	Peptidase, M16
FY536_06190	COG1426	Protein conserved in bacteria
FY536_06195	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
FY536_06200	COG1058	Belongs to the CinA family
FY536_06200	COG1546	Belongs to the CinA family
FY536_06205	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
FY536_06220	COG0024	Methionine aminopeptidase
FY536_06225	COG1719	4-vinyl reductase, 4VR
FY536_06235	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
FY536_06240	COG1234	tRNA 3'-trailer cleavage
FY536_06245	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
FY536_06245	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
FY536_06255	COG4224	UPF0291 protein
FY536_06260	COG3763	UPF0154 protein
FY536_06265	COG0204	Acyl-transferase
FY536_06270	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
FY536_06275	COG2827	Endonuclease containing a URI domain
FY536_06280	COG0052	Belongs to the universal ribosomal protein uS2 family
FY536_06285	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
FY536_06290	COG0528	UMP kinase activity
FY536_06300	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FY536_06305	COG1428	Deoxynucleoside kinase
FY536_06310	COG0546	phosphoglycolate phosphatase activity
FY536_06320	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
FY536_06335	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
FY536_06350	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FY536_06355	COG0617	tRNA 3'-terminal CCA addition
FY536_06360	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
FY536_06375	COG4862	establishment of competence for transformation
FY536_06385	COG1164	Oligoendopeptidase f
FY536_06390	COG0752	glycyl-tRNA synthetase alpha subunit
FY536_06395	COG0751	glycine-tRNA ligase activity
FY536_06410	COG2814	Major facilitator Superfamily
FY536_06420	COG0765	amino acid transport
FY536_06425	COG1126	abc transporter atp-binding protein
FY536_06430	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FY536_06435	COG2814	Major facilitator Superfamily
FY536_06445	COG3331	DNA recombination
FY536_06450	COG4474	Belongs to the UPF0398 family
FY536_06465	COG0116	Belongs to the methyltransferase superfamily
FY536_06475	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
FY536_06495	COG1132	(ABC) transporter
FY536_06500	COG0556	nucleotide-excision repair
FY536_06510	COG0564	pseudouridine synthase activity
FY536_06515	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
FY536_06520	COG0505	Belongs to the CarA family
FY536_06530	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FY536_06555	COG1304	FMN binding
FY536_06575	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
FY536_06575	COG1199	ATP-dependent helicase activity
FY536_06585	COG0017	Asparaginyl-tRNA synthetase
FY536_06590	COG0488	(ABC) transporter
FY536_06605	COG0587	DNA-directed DNA polymerase activity
FY536_06610	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FY536_06620	COG2996	Protein conserved in bacteria
FY536_06630	COG1187	pseudouridine synthase activity
FY536_06640	COG0514	ATP-dependent DNA helicase (RecQ)
FY536_06650	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
FY536_06655	COG0539	negative regulation of cytoplasmic translation
FY536_06660	COG1160	GTP binding
FY536_06670	COG4975	Glucose uptake
FY536_06675	COG0561	phosphatase activity
FY536_06680	COG0095	Lipoate-protein ligase
FY536_06710	COG1316	TRANSCRIPTIONal
FY536_06720	COG0489	protein tyrosine kinase activity
FY536_06725	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
FY536_06740	COG0583	DNA-binding transcription factor activity
FY536_06745	COG2855	membrane
FY536_06750	COG2199	diguanylate cyclase activity
FY536_06755	COG0791	NLP P60 protein
FY536_06755	COG3883	PFAM NLP P60 protein
FY536_06770	COG0358	DNA primase activity
FY536_06775	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FY536_06780	COG1420	regulation of RNA biosynthetic process
FY536_06785	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
FY536_06790	COG0443	Heat shock 70 kDa protein
FY536_06795	COG0484	heat shock protein binding
FY536_06815	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
FY536_06820	COG2211	Major facilitator Superfamily
FY536_06825	COG0745	RESPONSE REGULATOR receiver
FY536_06830	COG5002	protein histidine kinase activity
FY536_06835	COG0572	uridine kinase
FY536_06840	COG1363	Peptidase, m42
FY536_06845	COG0072	phenylalanine-tRNA ligase activity
FY536_06845	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FY536_06860	COG0670	Belongs to the BI1 family
FY536_06890	COG3706	GGDEF domain
FY536_06895	COG0583	DNA-binding transcription factor activity
FY536_06915	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
FY536_06935	COG3479	Phenolic acid decarboxylase
FY536_06940	COG1695	Transcriptional regulator
FY536_06945	COG0028	Belongs to the TPP enzyme family
FY536_06950	COG0653	protein targeting
FY536_06960	COG1073	alpha beta
FY536_06990	COG1181	Belongs to the D-alanine--D-alanine ligase family
FY536_06990	COG2918	glutathione biosynthetic process
FY536_07040	COG2217	Heavy metal translocating P-type atpase