locus-tag	class	description
C4597_00095	ENOG4105D9M	gamma-glutamylcysteine synthetase
C4597_00120	ENOG4106YAG	Part of the accessory SecA2 SecY2 system specifically required for export of
C4597_00130	ENOG41089G2	accessory Sec system protein Asp2
C4597_00145	ENOG4108MGR	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane (By similarity)
C4597_00150	ENOG4105C7K	acetolactate synthase
C4597_00155	ENOG4105U3E	Transcriptional regulator
C4597_00160	ENOG4105PY6	Phenolic acid decarboxylase
C4597_00165	ENOG4105TV1	Transcriptional regulator
C4597_00175	ENOG4105GH9	galactofuranosyltransferase
C4597_00200	ENOG4105G62	Translocase subunit
C4597_00205	ENOG4108MGR	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane (By similarity)
C4597_00215	ENOG4105EDE	A stabilizing protein that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon. Stabilizes the glycosylation activity of Gtf1 (By similarity)
C4597_00240	ENOG4105NA0	Transcriptional regulator
C4597_00245	ENOG4105TV1	Transcriptional regulator
C4597_00250	ENOG4107QSE	Dipeptidase
C4597_00255	ENOG4105CSX	c4-dicarboxylate anaerobic carrier
C4597_00260	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
C4597_00265	ENOG4106KNP	GTP-binding protein LepA C-terminus
C4597_00275	ENOG4105MKU	Transcriptional regulator
C4597_00290	ENOG4105D2N	Aldolase
C4597_00295	ENOG4108ZIE	5 nucleotidase deoxy cytosolic type C
C4597_00300	ENOG41082QR	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
C4597_00320	ENOG4105EGD	dinuclear metal center protein, YbgI family
C4597_00345	ENOG4105DJ2	Major Facilitator Superfamily
C4597_00350	ENOG4105PUK	Membrane
C4597_00355	ENOG4105DWF	phosphomethylpyrimidine kinase
C4597_00360	ENOG4105C2M	dna polymerase I
C4597_00365	ENOG4105RHA	ABC transporter, permease
C4597_00370	ENOG4108IUX	(ABC) transporter
C4597_00380	ENOG4105CIS	alcohol dehydrogenase
C4597_00385	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
C4597_00390	ENOG4107SJ1	Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity)
C4597_00395	ENOG4107XQC	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins (By similarity)
C4597_00405	ENOG4105E5Q	amino acid AbC transporter
C4597_00410	ENOG4105EAB	amino acid AbC transporter
C4597_00420	ENOG41063PX	domain protein
C4597_00430	ENOG4106H78	methyltransferase
C4597_00435	ENOG4105WUC	UPF0298 protein
C4597_00440	ENOG4105CNI	cell division protein FtsW
C4597_00445	ENOG4105CI3	gtp-binding protein typa
C4597_00450	ENOG4105ECY	inositol monophosphatase
C4597_00470	ENOG4108VXD	carboxy-peptidase
C4597_00490	ENOG4105E2M	Manganese-dependent inorganic pyrophosphatase
C4597_00500	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
C4597_00505	ENOG4108ZK7	protein family UPF0029, Impact, N-terminal protein
C4597_00510	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
C4597_00515	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
C4597_00520	ENOG4105CVJ	phosphoglycerate mutase
C4597_00525	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
C4597_00530	ENOG4107Z8R	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity)
C4597_00545	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
C4597_00550	ENOG4105K5M	30s ribosomal protein S16
C4597_00555	ENOG4105CB9	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
C4597_00560	ENOG4105VBN	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity)
C4597_00565	ENOG4105CCP	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
C4597_00570	ENOG4108ZBM	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity)
C4597_00575	ENOG4105VNB	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
C4597_00580	ENOG4105C6B	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity)
C4597_00585	ENOG4105CB5	ATP-dependent DNA helicase recG
C4597_00590	ENOG4105C7N	Xanthine uracil vitamin C permease
C4597_00595	ENOG4105C75	arginyL-tRNA synthetase
C4597_00605	ENOG4107EEN	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity)
C4597_00620	ENOG4108V0P	LemA family
C4597_00630	ENOG4105DP4	dak2 domain fusion protein ylov
C4597_00640	ENOG4105VB9	50S ribosomal protein l28
C4597_00645	ENOG4105FJ0	thiamine
C4597_00650	ENOG4105DJV	ribulose-phosphate 3-epimerase
C4597_00660	ENOG4105D9P	serine threonine protein kinase
C4597_00665	ENOG4108ZF3	Phosphatase
C4597_00670	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
C4597_00675	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
C4597_00680	ENOG4105C25	Primosomal protein n'
C4597_00720	ENOG4105CDY	transcriptional regulatory protein
C4597_00725	ENOG4108HMR	Key enzyme in the regulation of glycerol uptake and metabolism (By similarity)
C4597_00730	ENOG41069HH	4-oxalocrotonate tautomerase
C4597_00735	ENOG4107AYK	membrAne
C4597_00740	ENOG4105C1J	atp-dependent rna helicase
C4597_00745	ENOG4105SFS	phosphoesterase RecJ domain protein
C4597_00750	ENOG4105CQ3	Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity)
C4597_00755	ENOG4105VIE	preprotein translocase, subunit YajC
C4597_00760	ENOG4105C6U	Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity)
C4597_00765	ENOG4105E2N	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity)
C4597_00770	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
C4597_00775	ENOG4105KA4	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity)
C4597_00780	ENOG4105DFD	Na H antiporter
C4597_00785	ENOG4105C79	DNA protecting protein DprA
C4597_00790	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
C4597_00795	ENOG4105C9W	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity)
C4597_00800	ENOG4105VSD	UPF0346 protein
C4597_00815	ENOG4108RCR	degv family
C4597_00820	ENOG4105EPR	degv family
C4597_00830	ENOG4107QMW	pyridine nucleotide-disulfide oxidoreductase
C4597_00835	ENOG4105GR3	Histidine kinase
C4597_00840	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
C4597_00870	ENOG4105ERD	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity)
C4597_00880	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
C4597_00885	ENOG4105CZ1	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity)
C4597_00890	ENOG4105K59	histidine triad (HIT) protein
C4597_00900	ENOG4105KA3	membrAne
C4597_00905	ENOG4105KAV	tspo and mbr like protein
C4597_00920	ENOG4108UW5	maltose o-acetyltransferase
C4597_00925	ENOG4105EMU	Dehydrogenase
C4597_00930	ENOG4108M0I	Transcriptional regulator
C4597_00935	ENOG4107BMA	Transglycosylase associated protein
C4597_00965	ENOG4106EMP	CsbD-like
C4597_00980	ENOG4107BMA	Transglycosylase associated protein
C4597_00990	ENOG4105DP4	dak2 domain fusion protein ylov
C4597_00995	ENOG41090U3	tautomerase
C4597_01005	ENOG4108UXE	Protein tyrosine phosphatase
C4597_01010	ENOG4105DMQ	Methyltransferase
C4597_01015	ENOG4105KWG	Pfam:DUF1696
C4597_01110	ENOG4105EYG	tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity)
C4597_01315	ENOG4108UUM	single-stranded DNA-binding protein
C4597_01325	ENOG4108PNI	recT protein
C4597_01340	ENOG4105WXW	Antirepressor
C4597_01420	ENOG4105ETE	Transcriptional regulator (LacI family
C4597_01425	ENOG4105DC7	peptidase M24
C4597_01430	ENOG4105E05	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
C4597_01435	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
C4597_01440	ENOG4105WAZ	(Glutaredoxin-like protein) NrdH
C4597_01450	ENOG41067TZ	transcriptional regulator, MarR family
C4597_01455	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
C4597_01475	ENOG4105VR5	Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity)
C4597_01490	ENOG41087KY	Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity)
C4597_01500	ENOG4105DMZ	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity)
C4597_01505	ENOG4105CPY	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity)
C4597_01510	ENOG4105CJN	penicillin-binding protein
C4597_01525	ENOG4108V6E	Cell division protein mraZ
C4597_01535	ENOG4107TVK	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity)
C4597_01540	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
C4597_01545	ENOG4108IQI	permease
C4597_01560	ENOG4105N3I	Involved in formation and maintenance of cell shape (By similarity)
C4597_01565	ENOG4105DFF	Rod shape-determining protein mreb
C4597_01570	ENOG4105W5Q	DNA repair protein (RadC
C4597_01605	ENOG410667J	hydrolase
C4597_01610	ENOG4105CKA	Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity)
C4597_01615	ENOG4108R6W	Transcriptional regulator, ARAC family
C4597_01625	ENOG4105CRD	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity)
C4597_01630	ENOG4107RBJ	symporter
C4597_01660	ENOG41082DI	50s ribosomal protein l31
C4597_01665	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
C4597_01670	ENOG4108YY1	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity)
C4597_01680	ENOG4105EQI	Metal Dependent Phosphohydrolase
C4597_01685	ENOG4106D4I	domain protein
C4597_01690	ENOG4107RFY	SbcCD D subunit
C4597_01695	ENOG4105WZB	UPF0342 protein
C4597_01700	ENOG4105BZ4	penicillin-binding protein
C4597_01705	ENOG4105XBY	Regulates arginine biosynthesis genes (By similarity)
C4597_01720	ENOG4105KQV	Binds directly to 16S ribosomal RNA (By similarity)
C4597_01725	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
C4597_01730	ENOG4105TQK	DNA polymerase iii, delta' subunit
C4597_01735	ENOG4105EGY	DNA internalization-related competence protein ComEC Rec2
C4597_01740	ENOG4105KQC	Competence protein
C4597_01760	ENOG4105VPH	UPF0473 protein
C4597_01765	ENOG4105VPH	UPF0473 protein
C4597_01770	ENOG4108Z08	Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity)
C4597_01775	ENOG4105VBH	UPF0297 protein
C4597_01780	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
C4597_01785	ENOG4105C2C	drug resistance transporter, Bcr CflA
C4597_01790	ENOG4105CJW	magnesium transporter
C4597_01795	ENOG4105EMS	pseudouridine synthase
C4597_01800	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
C4597_01810	ENOG4105D5D	udp-galactopyranose mutase
C4597_01825	ENOG4105ZAD	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity)
C4597_01830	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
C4597_01835	ENOG4105C4F	May be involved in recombinational repair of damaged DNA (By similarity)
C4597_01840	ENOG4105XBY	Regulates arginine biosynthesis genes (By similarity)
C4597_01845	ENOG4105DX0	Hemolysin A
C4597_01850	ENOG4105CTB	Polyprenyl synthetase
C4597_01855	ENOG41067QG	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
C4597_01870	ENOG4105FDU	atp-dependent rna helicase
C4597_01875	ENOG4105EE0	oxidoreductase
C4597_01880	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
C4597_01890	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
C4597_01910	ENOG4108IJ7	Glycine betaine
C4597_01915	ENOG4107YZX	Universal stress protein
C4597_01935	ENOG4105D1H	recombination factor protein RarA
C4597_01940	ENOG4105C8A	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity)
C4597_01950	ENOG4105KJF	protein tyrosine phosphatase
C4597_01955	ENOG4105CF3	3-Hydroxyisobutyrate dehydrogenase
C4597_01965	ENOG4107QNK	)-transporter
C4597_01970	ENOG4105CAC	Catalyzes the conversion of L-arabinose to L-ribulose (By similarity)
C4597_01985	ENOG4105U0F	oligosaccharide H symporter, major facilitator superfamily (MFS)
C4597_01990	ENOG4105CUK	Alpha-N-arabinofuranosidase (EC 3.2.1.55)
C4597_01995	ENOG4105CMD	Transcriptional regulator, GntR family
C4597_02000	ENOG4105BZU	Histidine kinase
C4597_02020	ENOG4105CA9	Pyruvate kinase
C4597_02025	ENOG4107T0D	ABC, transporter
C4597_02030	ENOG4105C7J	ABC transporter, permease
C4597_02040	ENOG4105X71	Membrane
C4597_02060	ENOG4106A8V	Protein CrcB homolog
C4597_02070	ENOG4105PGM	cation diffusion facilitator family transporter
C4597_02080	ENOG4105CS9	pantothenic acid kinase
C4597_02085	ENOG4105EEM	helicase
C4597_02095	ENOG4105F3R	pts system mannose fructose sorbose family iid
C4597_02100	ENOG4105ETZ	PTS System
C4597_02125	ENOG4106N3A	copper homeostasis protein cutc
C4597_02160	ENOG41069UX	Beta-N-acetyl-hexosaminidase
C4597_02170	ENOG4107QJZ	Glycosyl transferase, family 2
C4597_02210	ENOG4105E0M	Sulfatase
C4597_02225	ENOG4105W2C	Glycosyl transferase
C4597_02230	ENOG4105BZF	Glycosyl transferase (Group 1
C4597_02240	ENOG4107QJF	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity)
C4597_02245	ENOG4107U5W	ybbr family
C4597_02255	ENOG4105EEQ	Na H antiporter
C4597_02265	ENOG4105DE5	Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity)
C4597_02275	ENOG4105K8N	protein family UPF0079, ATPase
C4597_02280	ENOG4108IJ2	phosphate acetyltransferase
C4597_02285	ENOG4105D5S	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity)
C4597_02295	ENOG41067S9	phage shock protein C, PspC
C4597_02310	ENOG4105G5W	regulator Fur family
C4597_02320	ENOG4105EA8	2-Nitropropane dioxygenase
C4597_02325	ENOG4105CHR	reductase
C4597_02330	ENOG4105BZW	Glycerate kinase
C4597_02365	ENOG4106F1P	AAA ATPase, central domain protein
C4597_02385	ENOG4105VUF	Transcriptional regulator
C4597_02410	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
C4597_02415	ENOG4105I2S	Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity)
C4597_02430	ENOG4105K46	50S ribosomal protein l27
C4597_02440	ENOG4105CDU	Replicative dna helicase
C4597_02445	ENOG4105K9Q	Binds to the 23S rRNA (By similarity)
C4597_02455	ENOG4105DRP	amino acid AbC transporter
C4597_02460	ENOG4105EAD	ABC transporter
C4597_02465	ENOG4105CT1	(ABC) transporter
C4597_02485	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
C4597_02490	ENOG4105BZ1	(ABC) transporter
C4597_02495	ENOG4105BZ1	(ABC) transporter
C4597_02500	ENOG4105C1N	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity)
C4597_02505	ENOG4105DKJ	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
C4597_02515	ENOG4105CGK	Exodeoxyribonuclease III
C4597_02535	ENOG4105II7	pyrroline-5-carboxylate reductase
C4597_02550	ENOG4105DFF	Rod shape-determining protein mreb
C4597_02555	ENOG4107EES	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity)
C4597_02560	ENOG4105CGH	5'-nucleotidase
C4597_02570	ENOG4108UV6	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity)
C4597_02575	ENOG4105DWF	phosphomethylpyrimidine kinase
C4597_02580	ENOG4105C4U	4-methyl-5-beta-hydroxyethylthiazole kinase
C4597_02585	ENOG4105ECB	domain protein
C4597_02595	ENOG4105IKJ	beta-galactosidase small subunit
C4597_02600	ENOG4105CNT	hydrolase family 2
C4597_02605	ENOG4105DKJ	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
C4597_02610	ENOG4105CAY	ferredoxin--nadp reductase
C4597_02625	ENOG4105D74	hydrolase
C4597_02640	ENOG4108RWN	rrna methyltransferase
C4597_02650	ENOG4105CG1	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity)
C4597_02655	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
C4597_02660	ENOG4105DR1	Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity)
C4597_02675	ENOG4108YZM	Toxic component of a toxin-antitoxin (TA) module (By similarity)
C4597_02680	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
C4597_02685	ENOG4105C1J	atp-dependent rna helicase
C4597_02690	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
C4597_02695	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
C4597_02700	ENOG4108Z1Y	Participates in both the initiation and recycling phases of transcription. In the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling (By similarity)
C4597_02705	ENOG4105DBZ	Dtdp-4-dehydrorhamnose reductase
C4597_02710	ENOG4105C1B	dTDP-glucose 4-6-dehydratase
C4597_02720	ENOG4108I19	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity)
C4597_02725	ENOG4108SHN	Glycosyl transferase, family 2
C4597_02750	ENOG4105C39	capsular polysaccharide phosphotransferase
C4597_02755	ENOG4108PQP	glycosyl transferase group 1
C4597_02760	ENOG4105DCI	Phosphohydrolase
C4597_02770	ENOG4105C0H	protease
C4597_02775	ENOG4105Q2H	domain protein
C4597_02790	ENOG4105BZU	Histidine kinase
C4597_02795	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
C4597_02800	ENOG4105VH8	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity)
C4597_02805	ENOG4108UUM	single-stranded DNA-binding protein
C4597_02810	ENOG4108ZDX	Binds together with S18 to 16S ribosomal RNA (By similarity)
C4597_02815	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
C4597_02820	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
C4597_02825	ENOG4105DFT	pur operon repressor
C4597_02830	ENOG4108HMR	Key enzyme in the regulation of glycerol uptake and metabolism (By similarity)
C4597_02840	ENOG4107R2I	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation
C4597_02845	ENOG4105C5N	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
C4597_02855	ENOG4107Y49	methyltransferase
C4597_02860	ENOG4105VTR	Integrase
C4597_02900	ENOG4108ZT0	50S ribosomal protein l17
C4597_02905	ENOG4105CTF	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
C4597_02910	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
C4597_02920	ENOG41067V7	50S ribosomal protein L36
C4597_02925	ENOG4105K9U	however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)
C4597_02930	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
C4597_02935	ENOG4105CGG	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity)
C4597_02940	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
C4597_02950	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
C4597_02955	ENOG4105K4C	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity)
C4597_02960	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
C4597_02965	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
C4597_02970	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
C4597_02975	ENOG4105KAR	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity)
C4597_02980	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
C4597_02985	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
C4597_02990	ENOG41082SA	50s ribosomal protein l29
C4597_02995	ENOG4108R70	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity)
C4597_03000	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
C4597_03005	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
C4597_03015	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
C4597_03020	ENOG41080UE	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
C4597_03025	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
C4597_03030	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
C4597_03035	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
C4597_03050	ENOG4107XB0	Lipopolysaccharide 1,2-N-acetylglucosaminetransferase
C4597_03060	ENOG4105JNK	Glycosyl transferase (Group 1
C4597_03075	ENOG4105ER6	polysaccharide biosynthesis protein
C4597_03095	ENOG4105D3Q	Sugar transferase
C4597_03110	ENOG4105EAG	UDP-N-acetylglucosamine 2-epimerase
C4597_03120	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
C4597_03125	ENOG4105KEG	ribosomal-protein-alanine acetyltransferase
C4597_03135	ENOG41072GX	Peptidase M22 Glycoprotease
C4597_03165	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
C4597_03170	ENOG4105ZMH	deoxynucleoside kinase
C4597_03175	ENOG4105KNM	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
C4597_03180	ENOG4105C4J	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
C4597_03185	ENOG4105J80	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity)
C4597_03190	ENOG4105CDG	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity)
C4597_03200	ENOG4107ZFM	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity)
C4597_03205	ENOG4105WS6	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
C4597_03210	ENOG4107RFS	it plays a direct role in the translocation of protons across the membrane (By similarity)
C4597_03215	ENOG4105CZ5	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity)
C4597_03220	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
C4597_03225	ENOG4105EK0	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
C4597_03230	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
C4597_03240	ENOG4107104	thymidine kinase
C4597_03245	ENOG4105F1K	Glutamine amidotransferase
C4597_03250	ENOG4105DMS	mur ligase
C4597_03260	ENOG4105CUB	amino acid
C4597_03275	ENOG4105DHI	Methyltransferase
C4597_03280	ENOG4107R7I	amino acid
C4597_03285	ENOG4105C7Q	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity)
C4597_03310	ENOG4105C8T	Leucyl-tRNA synthetase
C4597_03315	ENOG410841Q	phosphoesterase PA-phosphatase related protein
C4597_03325	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
C4597_03330	ENOG4105CWM	branched-chain amino acid transport system II carrier protein
C4597_03335	ENOG4107SC7	Inner membrane transporter yjeM
C4597_03340	ENOG4105DZW	Dipeptidase
C4597_03345	ENOG4107R7I	amino acid
C4597_03360	ENOG4105DU0	nucleoside hydrolase
C4597_03370	ENOG4107WD8	ABC transporter, permease
C4597_03375	ENOG4105CPH	Catalyzes the formation of S-adenosylmethionine from methionine and ATP
C4597_03385	ENOG4105BZU	Histidine kinase
C4597_03390	ENOG4105CSX	c4-dicarboxylate anaerobic carrier
C4597_03395	ENOG4105EV1	Ribose uptake protein RbsU
C4597_03400	ENOG4105MRB	Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity)
C4597_03410	ENOG4105F4P	)-transporter
C4597_03440	ENOG4108IJ8	ABC transporter
C4597_03460	ENOG4105KBC	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
C4597_03465	ENOG4108VZM	50s ribosomal protein L10
C4597_03470	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
C4597_03475	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
C4597_03480	ENOG4105E5V	Participates in transcription elongation, termination and antitermination (By similarity)
C4597_03490	ENOG4107FTN	50S ribosomal protein L33
C4597_03500	ENOG4105C2N	RNA methyltransferase TrmH family group 3
C4597_03505	ENOG4105KEB	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
C4597_03510	ENOG4105C8N	cysteinyl-tRNA synthetase
C4597_03515	ENOG4107RA1	nh(3)-dependent nad( ) synthetase
C4597_03520	ENOG4105DAP	Nicotinate phosphoribosyltransferase
C4597_03530	ENOG4105D01	(LipO)protein
C4597_03535	ENOG4108JEI	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity)
C4597_03540	ENOG4108UMI	ABC transporter, permease
C4597_03550	ENOG4105DG6	mannose-6-phosphate isomerase
C4597_03565	ENOG4108UT2	hemolysin iii
C4597_03570	ENOG4107QRI	Phosphoketolase
C4597_03575	ENOG4105DQW	permease for cytosine purines, uracil, thiamine, allantoin
C4597_03580	ENOG4108TZY	GntR Family Transcriptional Regulator
C4597_03610	ENOG4105C5H	ABC transporter
C4597_03615	ENOG4105FAV	ABC, transporter
C4597_03620	ENOG4105FDK	ABC transporter
C4597_03635	ENOG4105EXC	Acyl-transferase
C4597_03645	ENOG4105DUX	Transporter
C4597_03675	ENOG4105BZU	Histidine kinase
C4597_03690	ENOG4105C3G	gtp-binding protein
C4597_03695	ENOG4105VDK	protein, conserved in bacteria
C4597_03700	ENOG4105FA0	parb-like partition protein
C4597_03705	ENOG4107QJE	Chromosome Partitioning Protein
C4597_03735	ENOG4105C02	permease
C4597_03740	ENOG410855V	Acylphosphatase
C4597_03745	ENOG4105KIS	phospholipid-binding protein
C4597_03755	ENOG4105EMU	Dehydrogenase
C4597_03760	ENOG4105VUF	Transcriptional regulator
C4597_03765	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
C4597_03770	ENOG4108SAX	Membrane
C4597_03775	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
C4597_03790	ENOG4108Z40	Transcriptional regulator
C4597_03810	ENOG4107PP3	Acetylornithine deacetylase
C4597_03825	ENOG4105ECR	NmrA family
C4597_03830	ENOG4105CPC	Aldo Keto reductase
C4597_03835	ENOG4106W5V	Membrane
C4597_03845	ENOG4108UMW	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
C4597_03850	ENOG4108HCJ	Hydrolase
C4597_03860	ENOG4108UXA	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity)
C4597_03895	ENOG4107Y5K	Resolvase
C4597_03920	ENOG4105DUX	Transporter
C4597_03945	ENOG4105C3M	thioredoxin reductase
C4597_03955	ENOG4105K63	Thioredoxin
C4597_03970	ENOG4105TV1	Transcriptional regulator
C4597_04000	ENOG4105CV8	reductase
C4597_04010	ENOG4107653	Transcriptional regulator
C4597_04035	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
C4597_04045	ENOG4105VUF	Transcriptional regulator
C4597_04050	ENOG4105EMY	transcriptional regulator
C4597_04060	ENOG4105KT7	mgtC SapB transporter
C4597_04065	ENOG4105CIS	alcohol dehydrogenase
C4597_04075	ENOG4105D1H	recombination factor protein RarA
C4597_04160	ENOG4108UWZ	4-Carboxymuconolactone decarboxylase
C4597_04170	ENOG4106P55	Transcriptional regulator
C4597_04180	ENOG4107ZYR	domain protein
C4597_04185	ENOG4105C85	amino acid
C4597_04195	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
C4597_04200	ENOG4105M7T	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)
C4597_04205	ENOG4105VG0	50S ribosomal protein l34
C4597_04210	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
C4597_04215	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
C4597_04220	ENOG410848D	S4 domain protein YaaA
C4597_04225	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
C4597_04230	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
C4597_04235	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
C4597_04240	ENOG4105E0M	Sulfatase
C4597_04280	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
C4597_04285	ENOG4105F8V	Hydrolase, tatD family
C4597_04295	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
C4597_04300	ENOG4105C37	(CBS) domain
C4597_04305	ENOG4105W42	Veg protein
C4597_04310	ENOG4108UK2	deaminase
C4597_04315	ENOG4105C0V	Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity)
C4597_04320	ENOG4108KGH	TRANSCRIPTIONal
C4597_04335	ENOG4105DWR	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity)
C4597_04345	ENOG4105CEU	Arginine dihydrolase
C4597_04350	ENOG4105DBV	ornithine carbamoyltransferase
C4597_04355	ENOG4105D5Q	Arginine ornithine antiporter
C4597_04380	ENOG4105CKK	Glycosyl transferase, family 2
C4597_04405	ENOG4105C88	aminopeptidase
C4597_04415	ENOG4107U9W	Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S- specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX (By similarity)
C4597_04425	ENOG4105D8C	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity)
C4597_04435	ENOG4105HDK	L-asparaginase
C4597_04440	ENOG4105VEM	Conserved domain protein
C4597_04445	ENOG4108STX	response regulator
C4597_04450	ENOG4105US7	Histidine kinase
C4597_04460	ENOG4107SUZ	Sodium/hydrogen exchanger family
C4597_04465	ENOG4105K63	Thioredoxin
C4597_04480	ENOG4108ZPD	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity)
C4597_04485	ENOG4108JA2	transcriptioN-repair coupling factor
C4597_04495	ENOG41082I2	s4 domain protein
C4597_04505	ENOG4105D3U	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity)
C4597_04510	ENOG4108UGV	hypoxanthine phosphoribosyltransferase
C4597_04525	ENOG4105DU0	nucleoside hydrolase
C4597_04535	ENOG4105ETE	Transcriptional regulator (LacI family
C4597_04540	ENOG4105E66	phosphoriboisomerase A
C4597_04545	ENOG4105F4C	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity)
C4597_04550	ENOG4105CRK	lysyL-tRNA synthetase
C4597_04585	ENOG4105DZW	Dipeptidase
C4597_04595	ENOG4106KNT	transcriptional regulator
C4597_04630	ENOG4105KEX	transcriptional regulator, ctsr
C4597_04635	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
C4597_04640	ENOG4108IIJ	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
C4597_04645	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
C4597_04650	ENOG4108V1J	Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity)
C4597_04695	ENOG4108UPS	Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity)
C4597_04700	ENOG4105C9K	Endothelin-converting enzyme 1
C4597_04705	ENOG4108EKI	Dehydrogenase
C4597_04715	ENOG4105C2N	RNA methyltransferase TrmH family group 3
C4597_04720	ENOG4108JJB	ABC transporter
C4597_04725	ENOG4108JJB	ABC transporter
C4597_04735	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
C4597_04745	ENOG4105C6E	dna polymerase iii
C4597_04750	ENOG4105F3K	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity)
C4597_04760	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
C4597_04765	ENOG4105X0R	protein from nitrogen regulatory protein P-II
C4597_04770	ENOG4105FA2	dna polymerase iii
C4597_04785	ENOG4105CMR	udp-glucose 4-epimerase
C4597_04800	ENOG4105CPC	Aldo Keto reductase
C4597_04805	ENOG4105DAA	L-lactate
C4597_04855	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
C4597_04860	ENOG4108UJD	30S ribosomal protein S9
C4597_04875	ENOG4105CPQ	Dehydrogenase
C4597_04880	ENOG4105EEQ	Na H antiporter
C4597_04885	ENOG4108UQV	Membrane
C4597_04890	ENOG4105CBN	LysR family transcriptional regulator
C4597_04910	ENOG4105D7K	pfkb domain protein
C4597_04915	ENOG4108JQ1	Dehydrogenase
C4597_04920	ENOG4105CMG	Carbohydrate kinase
C4597_04925	ENOG4107XBN	GntR Family Transcriptional Regulator
C4597_04930	ENOG4105DEI	Mannitol dehydrogenase
C4597_04935	ENOG4105CHZ	Catalyzes the dehydration of D-mannonate (By similarity)
C4597_04950	ENOG4105CT4	transporter
C4597_04960	ENOG4105D2H	Uronic isomerase
C4597_04975	ENOG41075H3	AraC family transcriptional regulator
C4597_04980	ENOG4107R73	Mate efflux family protein
C4597_04985	ENOG4107QNK	)-transporter
C4597_04995	ENOG4105C93	Xylose Isomerase
C4597_05000	ENOG4105CMG	Carbohydrate kinase
C4597_05020	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
C4597_05030	ENOG4105C0X	amino acid
C4597_05045	ENOG4105C56	H( )-stimulated, divalent metal cation uptake system (By similarity)
C4597_05060	ENOG4105CHW	UPF0052 protein
C4597_05065	ENOG4105CIE	May be required for sporulation (By similarity)
C4597_05070	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
C4597_05085	ENOG4108YZK	glyoxalase bleomycin resistance protein dioxygenase
C4597_05115	ENOG4108UW5	maltose o-acetyltransferase
C4597_05125	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
C4597_05135	ENOG4107Z0P	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity)
C4597_05140	ENOG4105DNJ	May play a role in the repair of endogenous alkylation damage (By similarity)
C4597_05145	ENOG4105CTP	PilT protein domain protein
C4597_05150	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
C4597_05155	ENOG4105CSS	phenylalanyl-tRNA synthetase (alpha subunit)
C4597_05160	ENOG4105C6A	phenylalanyl-tRNA synthetase (beta subunit)
C4597_05175	ENOG4108UKH	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
C4597_05180	ENOG4107RF6	penicillin-binding protein
C4597_05185	ENOG4105MK2	5-formyltetrahydrofolate cyclo-ligase
C4597_05195	ENOG4105DKQ	ROK family
C4597_05200	ENOG4105K4H	Nlp p60 protein
C4597_05220	ENOG4105DKX	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)
C4597_05225	ENOG4105KV4	Transcriptional regulator
C4597_05230	ENOG4105C5F	glutamine synthetase
C4597_05250	ENOG4108UZ3	Transporter
C4597_05255	ENOG410807C	QueT transporter
C4597_05260	ENOG4105I7Z	Short-chain dehydrogenase reductase Sdr
C4597_05280	ENOG4105CTR	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity)
C4597_05285	ENOG4105CE4	GlcNAc 6-P deacetylase
C4597_05290	ENOG4105FDP	GntR family transcriptional regulator
C4597_05295	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
C4597_05305	ENOG4105C7N	Xanthine uracil vitamin C permease
C4597_05310	ENOG4105C91	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
C4597_05315	ENOG4108UGV	hypoxanthine phosphoribosyltransferase
C4597_05325	ENOG4105WH5	Teichoic acid glycosylation protein
C4597_05330	ENOG4108HCJ	Hydrolase
C4597_05335	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
C4597_05340	ENOG4105KNE	Phosphatidate cytidylyltransferase
C4597_05345	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
C4597_05355	ENOG4105DE5	Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity)
C4597_05400	ENOG4105DC7	peptidase M24
C4597_05415	ENOG4105MMD	transcriptional regulator
C4597_05420	ENOG4105D4U	had-superfamily hydrolase, subfamily iia
C4597_05425	ENOG4105CVA	phosphate
C4597_05430	ENOG4105C8U	phosphate abc transporter
C4597_05435	ENOG4105E2Z	phosphate ABC transporter (Permease
C4597_05440	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
C4597_05445	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
C4597_05450	ENOG4108UTW	Plays a role in the regulation of phosphate uptake
C4597_05460	ENOG4105DGY	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization (By similarity)
C4597_05465	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
C4597_05475	ENOG4105C40	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity)
C4597_05480	ENOG4108UH4	Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity)
C4597_05485	ENOG4105DUX	Transporter
C4597_05490	ENOG4107YB6	acetyltransferase, (GNAT) family
C4597_05500	ENOG4105VEQ	Cold shock protein
C4597_05525	ENOG4105C52	Atpase, p-type (Transporting), had superfamily, subfamily ic
C4597_05540	ENOG4105C59	p-type ATPase
C4597_05545	ENOG4105E4Y	Endoribonuclease that initiates mRNA decay (By similarity)
C4597_05550	ENOG4107RVG	penicillin-binding protein
C4597_05565	ENOG4105EJF	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity)
C4597_05575	ENOG4105KPY	Small multidrug resistance protein
C4597_05580	ENOG4108U05	Transcriptional regulator
C4597_05585	ENOG41090PH	Protease synthase and sporulation negative regulatory protein pai 1
C4597_05605	ENOG4106F5Q	Membrane
C4597_05610	ENOG4105DZC	cytosine deaminase
C4597_05615	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
C4597_05620	ENOG4105ENN	converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity)
C4597_05625	ENOG4107QYV	phosphohexose isomerase
C4597_05635	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
C4597_05640	ENOG4108ZSR	alkaline shock protein
C4597_05645	ENOG4105M7K	Involved in the transcription termination process (By similarity)
C4597_05650	ENOG4108UUX	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity)
C4597_05655	ENOG4105VJV	50s ribosomal protein L35
C4597_05660	ENOG4108YZX	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity)
C4597_05670	ENOG4108UKE	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity)
C4597_05675	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
C4597_05680	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
C4597_05685	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
C4597_05695	ENOG4105D38	putrescine abc transporter
C4597_05700	ENOG4107RUE	extracellular solute-binding protein family 1
C4597_05705	ENOG4108R5K	PPIases accelerate the folding of proteins (By similarity)
C4597_05715	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
C4597_05725	ENOG4105D1C	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity)
C4597_05740	ENOG4105C3M	thioredoxin reductase
C4597_05750	ENOG4105KRI	phosphocarrier protein (HPr
C4597_05755	ENOG4105BZ3	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity)
C4597_05760	ENOG4105CP7	Triose-phosphate isomerase
C4597_05765	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
C4597_05770	ENOG4105ZT7	DNA-entry nuclease
C4597_05795	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
C4597_05800	ENOG4105BZA	Phosphoglycerate kinase
C4597_05815	ENOG4105CQW	ribosome biogenesis GTPase YqeH
C4597_05825	ENOG4108Z1W	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity)
C4597_05830	ENOG4108WF2	Metal Dependent Phosphohydrolase
C4597_05835	ENOG4105KEM	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity)
C4597_05840	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
C4597_05845	ENOG4105CDE	UPF0348 protein
C4597_05855	ENOG4105D86	that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity)
C4597_05860	ENOG4105FF6	Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity)
C4597_05865	ENOG4105C5H	ABC transporter
C4597_05940	ENOG4105VTR	Integrase
C4597_05945	ENOG4105EVI	UPF0374 protein
C4597_05955	ENOG4105CHM	Aminotransferase
C4597_05965	ENOG4105M2E	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity)
C4597_05970	ENOG4105CKU	formyltetrahydrofolate synthetase
C4597_05980	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
C4597_05985	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
C4597_05995	ENOG4108V7D	UPF0397 protein
C4597_06005	ENOG4108W15	Protein of unknown function (DUF1456)
C4597_06015	ENOG4105C22	threonyL-tRNA synthetase
C4597_06025	ENOG4108JJB	ABC transporter
C4597_06035	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
C4597_06040	ENOG4105CPC	Aldo Keto reductase
C4597_06045	ENOG4108KP7	hydrolase
C4597_06055	ENOG4105VB5	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
C4597_06060	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
C4597_06065	ENOG4105CHT	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
C4597_06070	ENOG4105CBD	Diacylglycerol kinase
C4597_06080	ENOG4105HHQ	6-phosphogluconolactonase (EC 3.1.1.31)
C4597_06090	ENOG4105DQR	SNARE associated Golgi
C4597_06095	ENOG4108R5K	PPIases accelerate the folding of proteins (By similarity)
C4597_06100	ENOG4105BZM	domain protein
C4597_06210	ENOG4108ZW7	flagellar rod assembly protein muramidase flgj
C4597_06225	ENOG4105VEQ	Cold shock protein
C4597_06240	ENOG4105DUF	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity)
C4597_06245	ENOG4105K7D	Required for maturation of 30S ribosomal subunits (By similarity)
C4597_06250	ENOG4105CHV	Transcription elongation factor NusA
C4597_06255	ENOG4105VZN	Nucleic-acid-binding protein implicated in transcription termination
C4597_06265	ENOG4107QHU	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
C4597_06275	ENOG4105CNU	cell division protein FtsK
C4597_06305	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
C4597_06310	ENOG4105DEA	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation
C4597_06320	ENOG4105WHM	Necessary for normal cell division and for the maintenance of normal septation (By similarity)
C4597_06335	ENOG4105C98	muts2 protein
C4597_06340	ENOG4105CV8	reductase
C4597_06350	ENOG4105CJS	Phosphopantothenoylcysteine decarboxylase
C4597_06355	ENOG4105F99	Hydroxymethylglutaryl-CoA synthase
C4597_06365	ENOG4105C5C	n-acetylmuramoyl-l-alanine amidase
C4597_06370	ENOG4105CUT	histidyl-tRNA synthetase
C4597_06375	ENOG4105C9M	aspartyl-trna synthetase
C4597_06380	ENOG4107AYK	membrAne
C4597_06385	ENOG4105VCC	30S ribosomal protein S21
C4597_06390	ENOG4105KTH	gatB Yqey
C4597_06395	ENOG4105KGE	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity)
C4597_06400	ENOG4107YR5	Diacylglycerol kinase
C4597_06405	ENOG4105CWT	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity)
C4597_06410	ENOG4108SAY	Involved in DNA repair and RecF pathway recombination (By similarity)
C4597_06415	ENOG4108UIQ	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity)
C4597_06420	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
C4597_06425	ENOG4105DTN	riboflavin biosynthesis protein ribF
C4597_06430	ENOG4105F23	Fibronectin-binding protein
C4597_06435	ENOG4105EY8	ABC transporter
C4597_06450	ENOG4105CMG	Carbohydrate kinase
C4597_06455	ENOG4105C6Z	Gluconate
C4597_06460	ENOG4105CQX	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity)
C4597_06470	ENOG4108J6I	peptidase, M16
C4597_06480	ENOG4105BZQ	cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase
C4597_06485	ENOG4105CEV	competence damage-inducible protein
C4597_06490	ENOG4105C68	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)
C4597_06505	ENOG4105CA1	Removes the N-terminal methionine from nascent proteins (By similarity)
C4597_06520	ENOG4105K7Z	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity)
C4597_06525	ENOG4105IES	Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity)
C4597_06530	ENOG4105C2R	Single-stranded-DNA-specific exonuclease (RecJ)
C4597_06540	ENOG4105VPS	UPF0291 protein
C4597_06545	ENOG4105VXM	UPF0154 protein
C4597_06550	ENOG4105F6E	Acyl-transferase
C4597_06555	ENOG41060K3	Methyltransferase
C4597_06565	ENOG4105CE9	30S ribosomal protein S2
C4597_06570	ENOG4105CU7	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity)
C4597_06575	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
C4597_06585	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
C4597_06590	ENOG4105ZMH	deoxynucleoside kinase
C4597_06595	ENOG4107XGZ	Hydrolase
C4597_06605	ENOG4108V82	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
C4597_06620	ENOG4105C83	adenylosuccinate lyase
C4597_06635	ENOG4105C7H	Helicase, RecD TraA family
C4597_06645	ENOG4107AYK	membrAne
C4597_06660	ENOG4108SQ7	Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis
C4597_06670	ENOG4105DPN	Oligoendopeptidase f
C4597_06675	ENOG4108HMW	glycyl-tRNA synthetase, alpha subunit
C4597_06680	ENOG4105C38	Glycyl-tRNA synthetase beta subunit
C4597_06695	ENOG4105C6X	Major Facilitator
C4597_06705	ENOG4105E5Q	amino acid AbC transporter
C4597_06710	ENOG4105CDA	abc transporter atp-binding protein
C4597_06715	ENOG4105E89	ABC transporter
C4597_06720	ENOG410605W	Major Facilitator
C4597_06730	ENOG4108UI2	Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity)
C4597_06735	ENOG4108UKS	UPF0398 protein
C4597_06740	ENOG4105XWG	Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation (By similarity)
C4597_06750	ENOG4105C4H	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity)
C4597_06755	ENOG4105C4R	Atp-dependent dna helicase
C4597_06780	ENOG4105BZ1	(ABC) transporter
C4597_06785	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
C4597_06795	ENOG4105C34	Pseudouridine synthase
C4597_06800	ENOG4108UK1	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity)
C4597_06805	ENOG4105C1M	carbamoyl-phosphate synthetase glutamine chain
C4597_06810	ENOG4105CU6	carbamoyl-phosphate synthetase ammonia chain
C4597_06815	ENOG4107UUG	Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity)
C4597_06830	ENOG4105VBF	alkaline shock protein
C4597_06835	ENOG41064MX	Tetr family transcriptional regulator
C4597_06840	ENOG4106UJV	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity)
C4597_06860	ENOG4105DVT	helicase
C4597_06870	ENOG4105C5S	asparaginyl-tRNA synthetase
C4597_06875	ENOG4105C5H	ABC transporter
C4597_06890	ENOG4105C0B	DNA polymerase III (alpha subunit)
C4597_06895	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
C4597_06905	ENOG4105QNR	S1 RNA binding domain protein
C4597_06915	ENOG4105FE9	pseudouridine synthase
C4597_06925	ENOG4105C9U	ATP-dependent DNA helicase RecQ
C4597_06935	ENOG4105CAT	Cytidine monophosphate kinase
C4597_06940	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
C4597_06945	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
C4597_06955	ENOG4105CSC	Glucose uptake protein
C4597_06960	ENOG410667J	hydrolase
C4597_06965	ENOG4105DF9	Lipoate-protein, ligase
C4597_06970	ENOG4107RUY	(E1 component), alpha subunit
C4597_06985	ENOG4107QN2	dihydrolipoyl dehydrogenase
C4597_06995	ENOG4108KGH	TRANSCRIPTIONal
C4597_07005	ENOG4107YJ4	chain length determinant protein
C4597_07010	ENOG4105D3Q	Sugar transferase
C4597_07030	ENOG4105HMI	Membrane
C4597_07035	ENOG41064RH	membrane protein YliF
C4597_07040	ENOG4105Z8B	NlpC/P60 family
C4597_07055	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
C4597_07060	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
C4597_07065	ENOG4105CI8	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity)
C4597_07070	ENOG4105K90	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
C4597_07075	ENOG4105CFG	Acts as a chaperone (By similarity)
C4597_07080	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
C4597_07110	ENOG4105DPZ	Two component transcriptional regulator (Winged helix family
C4597_07115	ENOG4105BZU	Histidine kinase
C4597_07120	ENOG4105DBI	uridine monophosphokinase
C4597_07125	ENOG4105CN9	Peptidase m42 family protein
C4597_07130	ENOG4105C6A	phenylalanyl-tRNA synthetase (beta subunit)
C4597_07140	ENOG4105DFU	Cell wall formation (By similarity)
C4597_07145	ENOG4105HFZ	Membrane
C4597_07160	ENOG4105CHU	acetyl-coa acetyltransferase
C4597_07175	ENOG4105BZU	Histidine kinase
C4597_07180	ENOG4107ZGM	malolactic fermentation system
C4597_07200	ENOG4105D8C	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity)
C4597_07220	ENOG4105PY6	Phenolic acid decarboxylase
C4597_07225	ENOG4105U3E	Transcriptional regulator
C4597_07230	ENOG4105C7K	acetolactate synthase
C4597_07235	ENOG4108MGR	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane (By similarity)
C4597_07250	ENOG41089G2	accessory Sec system protein Asp2
C4597_07260	ENOG4106YAG	Part of the accessory SecA2 SecY2 system specifically required for export of
C4597_07290	ENOG4105D9M	gamma-glutamylcysteine synthetase
C4597_07315	ENOG4105IJJ	transcriptional regulator, crp fnr family
C4597_07320	ENOG4105C3B	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity)
C4597_07355	ENOG4105DS0	Transcriptional regulator, Crp Fnr family
C4597_07370	ENOG4105HUF	DNA protection during starvation protein
C4597_07380	ENOG4105EVU	fructokinase
C4597_07395	ENOG4105CPQ	Dehydrogenase
C4597_07505	ENOG4106H3A	restriction
C4597_07510	ENOG4105HUF	DNA protection during starvation protein
C4597_07555	ENOG41067QW	Transcriptional regulator