locus-tag	class	description
C4597_00095	COG1181	Belongs to the D-alanine--D-alanine ligase family
C4597_00095	COG2918	glutathione biosynthetic process
C4597_00130	COG1073	alpha beta
C4597_00145	COG0653	protein targeting
C4597_00150	COG0028	Belongs to the TPP enzyme family
C4597_00155	COG1695	Transcriptional regulator
C4597_00160	COG3479	Phenolic acid decarboxylase
C4597_00165	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C4597_00205	COG0653	protein targeting
C4597_00220	COG0438	transferase activity, transferring glycosyl groups
C4597_00225	COG2233	PERMEase
C4597_00230	COG2217	Heavy metal translocating P-type atpase
C4597_00245	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C4597_00250	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C4597_00255	COG1288	antiporter activity
C4597_00260	COG0477	Major facilitator Superfamily
C4597_00265	COG0481	GTPase activity
C4597_00275	COG1309	transcriptional regulator
C4597_00300	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C4597_00305	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C4597_00315	COG2195	Cleaves the N-terminal amino acid of tripeptides
C4597_00320	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
C4597_00325	COG2384	SAM-dependent methyltransferase
C4597_00345	COG2807	transmembrane transport
C4597_00350	COG4720	Psort location CytoplasmicMembrane, score
C4597_00355	COG0351	phosphomethylpyrimidine kinase
C4597_00360	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C4597_00360	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C4597_00365	COG1668	transmembrane transport
C4597_00370	COG4152	abc transporter atp-binding protein
C4597_00380	COG0604	alcohol dehydrogenase
C4597_00385	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C4597_00390	COG0516	GMP reductase activity
C4597_00395	COG0706	membrane insertase activity
C4597_00405	COG0765	amino acid transport
C4597_00410	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4597_00420	COG3480	Lon protease (S16) C-terminal proteolytic domain
C4597_00425	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
C4597_00430	COG0742	ribosomal rna small subunit methyltransferase
C4597_00435	COG4471	UPF0298 protein
C4597_00440	COG0772	Belongs to the SEDS family
C4597_00450	COG0483	inositol monophosphate 1-phosphatase activity
C4597_00460	COG0242	peptide deformylase activity
C4597_00470	COG1876	peptidase activity
C4597_00485	COG1597	lipid kinase activity
C4597_00490	COG1227	inorganic diphosphatase activity
C4597_00500	COG0187	DNA topoisomerase II activity
C4597_00505	COG1739	Uncharacterized protein family UPF0029
C4597_00515	COG0322	excinuclease ABC activity
C4597_00520	COG0406	alpha-ribazole phosphatase activity
C4597_00525	COG0336	Belongs to the RNA methyltransferase TrmD family
C4597_00545	COG0477	Major facilitator Superfamily
C4597_00550	COG0228	four-way junction DNA binding
C4597_00555	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
C4597_00560	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
C4597_00565	COG0552	protein localization to endoplasmic reticulum
C4597_00570	COG0571	ribonuclease III activity
C4597_00575	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C4597_00580	COG0416	fatty acid biosynthetic process
C4597_00585	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C4597_00590	COG2252	PERMEase
C4597_00595	COG0018	arginyl-trna synthetase
C4597_00615	COG0501	Belongs to the peptidase M48B family
C4597_00620	COG1704	LemA family
C4597_00625	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C4597_00630	COG1461	Dihydroxyacetone kinase
C4597_00640	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C4597_00645	COG1564	THIamine pyrophosphokinase
C4597_00650	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C4597_00655	COG1162	GTPase activity
C4597_00660	COG2815	serine threonine protein kinase
C4597_00660	COG0515	serine threonine protein kinase
C4597_00665	COG0631	protein serine/threonine phosphatase activity
C4597_00670	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C4597_00670	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C4597_00675	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C4597_00680	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C4597_00685	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
C4597_00715	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C4597_00730	COG1942	4-Oxalocrotonate Tautomerase
C4597_00735	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C4597_00740	COG0513	Belongs to the DEAD box helicase family
C4597_00745	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
C4597_00750	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C4597_00755	COG1862	Preprotein translocase
C4597_00760	COG0343	queuine tRNA-ribosyltransferase activity
C4597_00765	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
C4597_00770	COG2255	four-way junction helicase activity
C4597_00775	COG0632	four-way junction helicase activity
C4597_00785	COG0758	DNA mediated transformation
C4597_00790	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C4597_00800	COG4479	Belongs to the UPF0346 family
C4597_00815	COG1307	EDD domain protein, DegV family
C4597_00820	COG1307	EDD domain protein, DegV family
C4597_00830	COG0446	pyridine nucleotide-disulphide oxidoreductase
C4597_00835	COG5002	protein histidine kinase activity
C4597_00840	COG0745	RESPONSE REGULATOR receiver
C4597_00855	COG1484	DNA-dependent DNA replication
C4597_00870	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C4597_00880	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C4597_00885	COG0220	tRNA (guanine-N7-)-methyltransferase activity
C4597_00890	COG0537	adenosine 5'-monophosphoramidase activity
C4597_00900	COG3759	membrane
C4597_00905	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
C4597_00925	COG4221	oxidoreductase activity
C4597_00930	COG0583	DNA-binding transcription factor activity
C4597_00935	COG2261	transglycosylase associated protein
C4597_00965	COG3237	CsbD-like
C4597_00980	COG2261	transglycosylase associated protein
C4597_00990	COG1461	Dihydroxyacetone kinase
C4597_00995	COG1942	4-Oxalocrotonate Tautomerase
C4597_01005	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C4597_01010	COG2226	methyltransferase
C4597_01110	COG0582	viral genome integration into host DNA
C4597_01245	COG5484	DNA packaging
C4597_01315	COG0629	single-stranded DNA binding
C4597_01325	COG3723	Recombinational DNA repair protein, rece pathway
C4597_01340	COG3617	BRO family, N-terminal domain
C4597_01410	COG0582	viral genome integration into host DNA
C4597_01420	COG1609	Transcriptional regulator
C4597_01425	COG0006	proline dipeptidase activity
C4597_01430	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C4597_01435	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C4597_01450	COG1846	Transcriptional regulator
C4597_01455	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
C4597_01460	COG3599	regulation of cell shape
C4597_01475	COG1799	cell septum assembly
C4597_01490	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
C4597_01495	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C4597_01500	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C4597_01505	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C4597_01520	COG0275	rRNA processing
C4597_01525	COG2001	Belongs to the MraZ family
C4597_01535	COG1385	rRNA (uridine-N3-)-methyltransferase activity
C4597_01540	COG2264	protein methyltransferase activity
C4597_01545	COG0833	amino acid
C4597_01565	COG1077	Cell shape determining protein MreB Mrl
C4597_01570	COG2003	Belongs to the UPF0758 family
C4597_01605	COG0561	phosphatase activity
C4597_01610	COG0363	glucosamine-6-phosphate deaminase activity
C4597_01615	COG2207	Transcriptional regulator
C4597_01625	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
C4597_01660	COG0254	rRNA binding
C4597_01670	COG0335	large ribosomal subunit rRNA binding
C4597_01680	COG3481	metal-dependent phosphohydrolase, HD sub domain
C4597_01685	COG4717	serine-type aminopeptidase activity
C4597_01690	COG0420	3'-5' exonuclease activity
C4597_01695	COG3679	Belongs to the UPF0342 family
C4597_01700	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C4597_01705	COG1438	arginine binding
C4597_01715	COG1136	(ABC) transporter
C4597_01720	COG0268	Binds directly to 16S ribosomal RNA
C4597_01725	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
C4597_01730	COG1466	dna polymerase III delta subunit
C4597_01735	COG2333	competence protein COMEC
C4597_01735	COG0658	competence protein
C4597_01740	COG1596	polysaccharide export
C4597_01740	COG1555	photosystem II stabilization
C4597_01760	COG3906	Belongs to the UPF0473 family
C4597_01765	COG3906	Belongs to the UPF0473 family
C4597_01775	COG4472	Bacterial protein of unknown function (DUF965)
C4597_01780	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C4597_01785	COG2814	Major facilitator Superfamily
C4597_01790	COG2239	Acts as a magnesium transporter
C4597_01795	COG0564	pseudouridine synthase activity
C4597_01800	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C4597_01805	COG2357	RelA SpoT domain protein
C4597_01810	COG0562	UDP-galactopyranose mutase
C4597_01825	COG1758	RNA polymerase activity
C4597_01830	COG0194	GDP metabolic process
C4597_01835	COG0497	DNA recombination
C4597_01840	COG1438	arginine binding
C4597_01845	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
C4597_01850	COG0142	geranyltranstransferase activity
C4597_01855	COG1722	exodeoxyribonuclease VII activity
C4597_01865	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C4597_01870	COG0513	Belongs to the DEAD box helicase family
C4597_01875	COG0673	inositol 2-dehydrogenase activity
C4597_01880	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C4597_01890	COG0525	valine-tRNA ligase activity
C4597_01910	COG4175	Glycine betaine
C4597_01910	COG3448	diguanylate cyclase activity
C4597_01915	COG0589	response to stress
C4597_01935	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C4597_01940	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
C4597_01950	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C4597_01955	COG2084	Dehydrogenase
C4597_01960	COG0656	L-ascorbic acid biosynthetic process
C4597_01965	COG2814	Major facilitator Superfamily
C4597_01970	COG2160	L-arabinose isomerase activity
C4597_01985	COG2211	Major facilitator Superfamily
C4597_01990	COG3940	Belongs to the glycosyl hydrolase 43 family
C4597_01995	COG1609	Transcriptional regulator
C4597_02000	COG3706	GGDEF domain
C4597_02025	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
C4597_02030	COG4120	Belongs to the binding-protein-dependent transport system permease family
C4597_02040	COG4720	Psort location CytoplasmicMembrane, score
C4597_02050	COG2814	Major facilitator Superfamily
C4597_02060	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C4597_02070	COG1230	cation diffusion facilitator family transporter
C4597_02075	COG1388	LysM domain
C4597_02080	COG1072	(Pantothenic acid kinase))
C4597_02085	COG3973	AAA domain
C4597_02095	COG3716	PTS system mannose fructose sorbose family IID component
C4597_02100	COG3715	PTS system
C4597_02160	COG3583	domain protein
C4597_02160	COG3064	Membrane
C4597_02160	COG3525	Glycosyl hydrolase, family 20, catalytic domain
C4597_02210	COG1368	sulfuric ester hydrolase activity
C4597_02225	COG0438	transferase activity, transferring glycosyl groups
C4597_02230	COG0438	transferase activity, transferring glycosyl groups
C4597_02240	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C4597_02245	COG4856	YbbR-like protein
C4597_02260	COG0812	UDP-N-acetylmuramate dehydrogenase activity
C4597_02275	COG0802	atpase or kinase
C4597_02280	COG0280	phosphate acetyltransferase
C4597_02285	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
C4597_02295	COG1983	PspC domain protein
C4597_02310	COG0735	belongs to the Fur family
C4597_02320	COG2070	2-Nitropropane dioxygenase
C4597_02330	COG1929	Belongs to the glycerate kinase type-1 family
C4597_02335	COG0024	Methionine aminopeptidase
C4597_02365	COG0464	growth
C4597_02385	COG0789	Transcriptional regulator
C4597_02390	COG0656	L-ascorbic acid biosynthetic process
C4597_02410	COG1136	(ABC) transporter
C4597_02415	COG0577	efflux transmembrane transporter activity
C4597_02430	COG0211	Belongs to the bacterial ribosomal protein bL27 family
C4597_02435	COG0261	This protein binds to 23S rRNA in the presence of protein L20
C4597_02440	COG0305	Participates in initiation and elongation during chromosome replication
C4597_02445	COG0359	binds to the 23S rRNA
C4597_02455	COG0765	amino acid transport
C4597_02460	COG0765	amino acid transport
C4597_02465	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4597_02485	COG0577	efflux transmembrane transporter activity
C4597_02485	COG1136	(ABC) transporter
C4597_02490	COG1132	(ABC) transporter
C4597_02495	COG1132	(ABC) transporter
C4597_02505	COG0588	phosphoglycerate mutase activity
C4597_02515	COG0708	Exodeoxyribonuclease III
C4597_02535	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C4597_02540	COG0772	Belongs to the SEDS family
C4597_02550	COG1077	Cell shape determining protein MreB Mrl
C4597_02555	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C4597_02560	COG0737	Belongs to the 5'-nucleotidase family
C4597_02570	COG0352	thiamine-phosphate diphosphorylase activity
C4597_02575	COG0351	phosphomethylpyrimidine kinase
C4597_02580	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
C4597_02585	COG1511	domain protein
C4597_02595	COG3250	beta-galactosidase activity
C4597_02605	COG0588	phosphoglycerate mutase activity
C4597_02610	COG0492	ferredoxin-NADP+ reductase activity
C4597_02625	COG0596	Alpha beta hydrolase
C4597_02630	COG1733	regulation of RNA biosynthetic process
C4597_02640	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C4597_02650	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
C4597_02655	COG0653	protein targeting
C4597_02660	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
C4597_02675	COG2337	Toxic component of a toxin-antitoxin (TA) module
C4597_02690	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C4597_02695	COG0504	CTP synthase activity
C4597_02705	COG1091	dTDP-4-dehydrorhamnose reductase activity
C4597_02710	COG1088	dTDP-glucose 4,6-dehydratase activity
C4597_02720	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
C4597_02725	COG1215	transferase activity, transferring glycosyl groups
C4597_02750	COG0438	transferase activity, transferring glycosyl groups
C4597_02755	COG0438	transferase activity, transferring glycosyl groups
C4597_02760	COG1078	dGTPase activity
C4597_02770	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C4597_02775	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
C4597_02790	COG5002	protein histidine kinase activity
C4597_02795	COG0745	RESPONSE REGULATOR receiver
C4597_02800	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C4597_02805	COG0629	single-stranded DNA binding
C4597_02810	COG0360	Binds together with S18 to 16S ribosomal RNA
C4597_02815	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C4597_02820	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C4597_02825	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C4597_02830	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C4597_02840	COG1074	ATP-dependent DNA helicase activity
C4597_02845	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
C4597_02855	COG2813	Specifically methylates the guanine in position
C4597_02860	COG0582	viral genome integration into host DNA
C4597_02895	COG1064	alcohol dehydrogenase
C4597_02900	COG0203	ribosomal protein L17
C4597_02905	COG0202	RNA polymerase activity
C4597_02910	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
C4597_02915	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
C4597_02925	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
C4597_02930	COG0563	adenylate kinase activity
C4597_02940	COG0200	Binds to the 23S rRNA
C4597_02945	COG1841	ribosomal large subunit assembly
C4597_02950	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
C4597_02955	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
C4597_02960	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
C4597_02965	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
C4597_02970	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
C4597_02975	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
C4597_02980	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
C4597_02990	COG0255	Belongs to the universal ribosomal protein uL29 family
C4597_02995	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
C4597_03000	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
C4597_03005	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
C4597_03010	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
C4597_03015	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
C4597_03020	COG0089	rRNA binding
C4597_03030	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
C4597_03035	COG0051	transcription antitermination factor activity, RNA binding
C4597_03060	COG0438	transferase activity, transferring glycosyl groups
C4597_03070	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
C4597_03075	COG2244	polysaccharide biosynthetic process
C4597_03095	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C4597_03110	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
C4597_03120	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
C4597_03125	COG0456	acetyltransferase
C4597_03135	COG1214	PFAM Peptidase M22, glycoprotease
C4597_03165	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C4597_03170	COG1428	Deoxynucleoside kinase
C4597_03175	COG0355	proton-transporting ATP synthase activity, rotational mechanism
C4597_03180	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
C4597_03185	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
C4597_03190	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
C4597_03200	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
C4597_03205	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C4597_03210	COG0356	it plays a direct role in the translocation of protons across the membrane
C4597_03215	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
C4597_03220	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C4597_03225	COG0009	L-threonylcarbamoyladenylate synthase
C4597_03230	COG2890	protein-(glutamine-N5) methyltransferase activity
C4597_03240	COG1435	thymidine kinase activity
C4597_03245	COG3442	glutamine amidotransferase
C4597_03250	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C4597_03260	COG0531	amino acid
C4597_03275	COG0500	methyltransferase
C4597_03280	COG0531	amino acid
C4597_03285	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
C4597_03295	COG2244	polysaccharide biosynthetic process
C4597_03310	COG0495	leucyl-tRNA aminoacylation
C4597_03315	COG0671	phosphoesterase, PA-phosphatase related
C4597_03325	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C4597_03330	COG1114	Component of the transport system for branched-chain amino acids
C4597_03335	COG0531	amino acid
C4597_03345	COG0531	amino acid
C4597_03360	COG1957	nucleoside hydrolase
C4597_03365	COG1136	(ABC) transporter
C4597_03370	COG0577	efflux transmembrane transporter activity
C4597_03375	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
C4597_03380	COG0784	Response regulator, receiver
C4597_03385	COG4251	negative regulation of phosphorylation
C4597_03390	COG1288	antiporter activity
C4597_03400	COG1869	D-ribose catabolic process
C4597_03410	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
C4597_03450	COG1522	sequence-specific DNA binding
C4597_03460	COG0222	ribosome binding
C4597_03465	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
C4597_03470	COG0081	regulation of translation
C4597_03475	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
C4597_03480	COG0250	Participates in transcription elongation, termination and antitermination
C4597_03500	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C4597_03505	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
C4597_03510	COG0215	cysteine-tRNA ligase activity
C4597_03515	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
C4597_03520	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
C4597_03535	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C4597_03550	COG1482	cell wall glycoprotein biosynthetic process
C4597_03565	COG1272	protein, Hemolysin III
C4597_03570	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
C4597_03575	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
C4597_03580	COG2188	Transcriptional regulator
C4597_03585	COG2814	Major facilitator Superfamily
C4597_03610	COG0488	(ABC) transporter
C4597_03615	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C4597_03620	COG1121	(ABC) transporter
C4597_03635	COG2755	lipolytic protein G-D-S-L family
C4597_03635	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
C4597_03645	COG3104	oligopeptide transport
C4597_03655	COG0300	oxidoreductase activity
C4597_03675	COG5002	protein histidine kinase activity
C4597_03690	COG0012	GTP binding
C4597_03695	COG4481	Protein conserved in bacteria
C4597_03700	COG1475	DNA binding
C4597_03705	COG1192	Involved in chromosome partitioning
C4597_03710	COG0357	Ribosomal RNA small subunit methyltransferase G
C4597_03715	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C4597_03735	COG0628	permease
C4597_03740	COG1254	Belongs to the acylphosphatase family
C4597_03745	COG1881	PFAM PEBP family protein
C4597_03755	COG4221	oxidoreductase activity
C4597_03760	COG0789	Transcriptional regulator
C4597_03765	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C4597_03770	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
C4597_03790	COG1959	2 iron, 2 sulfur cluster binding
C4597_03810	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C4597_03825	COG0702	epimerase
C4597_03830	COG0667	Aldo Keto reductase
C4597_03835	COG0586	Pfam SNARE associated Golgi protein
C4597_03845	COG0328	RNA-DNA hybrid ribonuclease activity
C4597_03850	COG0561	phosphatase activity
C4597_03855	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C4597_03860	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
C4597_03895	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
C4597_03920	COG3104	oligopeptide transport
C4597_03945	COG0492	ferredoxin-NADP+ reductase activity
C4597_03950	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C4597_03955	COG3118	belongs to the thioredoxin family
C4597_03970	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C4597_04000	COG0656	L-ascorbic acid biosynthetic process
C4597_04010	COG0583	DNA-binding transcription factor activity
C4597_04030	COG0604	alcohol dehydrogenase
C4597_04035	COG1902	pentaerythritol trinitrate reductase activity
C4597_04045	COG0789	Transcriptional regulator
C4597_04050	COG0583	DNA-binding transcription factor activity
C4597_04060	COG1285	pathogenesis
C4597_04075	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C4597_04160	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C4597_04170	COG0583	DNA-binding transcription factor activity
C4597_04175	COG1442	glycosyl transferase family 8
C4597_04180	COG0569	domain protein
C4597_04185	COG1113	amino acid transport
C4597_04195	COG0706	membrane insertase activity
C4597_04200	COG0594	ribonuclease P activity
C4597_04205	COG0230	Belongs to the bacterial ribosomal protein bL34 family
C4597_04210	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C4597_04215	COG0592	DNA-directed DNA polymerase activity
C4597_04220	COG2501	S4 domain
C4597_04225	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C4597_04230	COG0187	DNA topoisomerase II activity
C4597_04240	COG1368	sulfuric ester hydrolase activity
C4597_04280	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C4597_04280	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C4597_04285	COG0084	hydrolase, TatD family'
C4597_04290	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
C4597_04300	COG1253	flavin adenine dinucleotide binding
C4597_04305	COG4466	Protein conserved in bacteria
C4597_04310	COG2131	deaminase
C4597_04315	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
C4597_04320	COG1316	TRANSCRIPTIONal
C4597_04335	COG1968	undecaprenyl-diphosphatase activity
C4597_04345	COG2235	arginine
C4597_04355	COG0531	amino acid
C4597_04380	COG0463	Glycosyl transferase, family 2
C4597_04390	COG0463	Glycosyl transferase, family 2
C4597_04405	COG2309	aminopeptidase activity
C4597_04415	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
C4597_04425	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C4597_04430	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
C4597_04435	COG0252	asparaginase activity
C4597_04440	COG4443	Transcriptional Coactivator p15 (PC4)
C4597_04445	COG0745	RESPONSE REGULATOR receiver
C4597_04450	COG5002	protein histidine kinase activity
C4597_04460	COG0025	NhaP-type Na H and K H
C4597_04465	COG3118	belongs to the thioredoxin family
C4597_04480	COG0193	aminoacyl-tRNA hydrolase activity
C4597_04485	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
C4597_04490	COG2244	polysaccharide biosynthetic process
C4597_04495	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
C4597_04530	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C4597_04535	COG1609	Transcriptional regulator
C4597_04545	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
C4597_04550	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
C4597_04590	COG1113	amino acid transport
C4597_04595	COG1737	Transcriptional regulator
C4597_04600	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
C4597_04630	COG4463	regulation of RNA biosynthetic process
C4597_04635	COG0542	response to heat
C4597_04640	COG0085	RNA polymerase activity
C4597_04645	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
C4597_04650	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
C4597_04665	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
C4597_04675	COG0813	purine-nucleoside phosphorylase activity
C4597_04695	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C4597_04700	COG3590	peptidase
C4597_04705	COG1454	alcohol dehydrogenase
C4597_04705	COG1012	belongs to the aldehyde dehydrogenase family
C4597_04710	COG1252	NADH dehydrogenase
C4597_04715	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C4597_04720	COG1122	ATPase activity
C4597_04725	COG1122	ATPase activity
C4597_04735	COG0101	tRNA pseudouridine synthase activity
C4597_04745	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
C4597_04760	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
C4597_04765	COG3870	Protein conserved in bacteria
C4597_04770	COG0470	DNA polymerase III
C4597_04785	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C4597_04800	COG0667	Aldo Keto reductase
C4597_04805	COG1620	l-lactate permease
C4597_04810	COG0438	transferase activity, transferring glycosyl groups
C4597_04875	COG1063	alcohol dehydrogenase
C4597_04885	COG1811	Na channel or pump
C4597_04890	COG0583	DNA-binding transcription factor activity
C4597_04910	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C4597_04915	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C4597_04920	COG1070	Carbohydrate kinase
C4597_04925	COG1802	Transcriptional regulator
C4597_04930	COG0246	Mannitol dehydrogenase
C4597_04935	COG1312	Catalyzes the dehydration of D-mannonate
C4597_04940	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
C4597_04950	COG2211	Major facilitator Superfamily
C4597_04960	COG1904	glucuronate isomerase
C4597_04975	COG2207	Transcriptional regulator
C4597_04980	COG0534	Mate efflux family protein
C4597_04995	COG2115	Belongs to the xylose isomerase family
C4597_05020	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C4597_05030	COG0531	amino acid
C4597_05040	COG1181	Belongs to the D-alanine--D-alanine ligase family
C4597_05045	COG1914	H( )-stimulated, divalent metal cation uptake system
C4597_05060	COG0391	Required for morphogenesis under gluconeogenic growth conditions
C4597_05065	COG1481	regulation of sporulation
C4597_05070	COG0740	serine-type endopeptidase activity
C4597_05085	COG0346	lactoylglutathione lyase activity
C4597_05115	COG0110	maltose O-acetyltransferase activity
C4597_05125	COG0542	response to heat
C4597_05135	COG0756	dUTP diphosphatase activity
C4597_05145	COG4956	integral membrane protein (PIN domain superfamily)
C4597_05155	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
C4597_05160	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C4597_05160	COG0072	phenylalanine-tRNA ligase activity
C4597_05165	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C4597_05175	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C4597_05180	COG0768	penicillin binding
C4597_05185	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C4597_05195	COG1940	carbohydrate kinase activity
C4597_05200	COG1388	LysM domain
C4597_05200	COG0791	NLP P60 protein
C4597_05220	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
C4597_05225	COG0789	Transcriptional regulator
C4597_05230	COG0174	glutamine synthetase
C4597_05250	COG0697	spore germination
C4597_05255	COG4708	membrane
C4597_05260	COG1028	Short-chain dehydrogenase reductase Sdr
C4597_05285	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
C4597_05295	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
C4597_05305	COG2252	PERMEase
C4597_05310	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
C4597_05325	COG2246	polysaccharide biosynthetic process
C4597_05330	COG0561	phosphatase activity
C4597_05335	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C4597_05340	COG4589	Belongs to the CDS family
C4597_05345	COG0442	prolyl-tRNA aminoacylation
C4597_05355	COG2176	DNA-directed DNA polymerase activity
C4597_05385	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
C4597_05400	COG0006	proline dipeptidase activity
C4597_05415	COG4470	Protein conserved in bacteria
C4597_05420	COG0647	UMP catabolic process
C4597_05425	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
C4597_05430	COG0573	inorganic phosphate transmembrane transporter activity
C4597_05435	COG0581	inorganic phosphate transmembrane transporter activity
C4597_05445	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C4597_05450	COG0704	Plays a role in the regulation of phosphate uptake
C4597_05460	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
C4597_05475	COG0557	exoribonuclease II activity
C4597_05480	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
C4597_05490	COG2153	protein acetylation
C4597_05500	COG1278	Cold shock
C4597_05515	COG2183	response to ionizing radiation
C4597_05540	COG2217	Heavy metal translocating P-type atpase
C4597_05550	COG0768	penicillin binding
C4597_05565	COG1051	belongs to the nudix hydrolase family
C4597_05575	COG2076	Multidrug Resistance protein
C4597_05580	COG1846	Transcriptional regulator
C4597_05585	COG0456	acetyltransferase
C4597_05595	COG2233	PERMEase
C4597_05605	COG0628	permease
C4597_05610	COG0402	S-adenosylhomocysteine deaminase activity
C4597_05615	COG0745	RESPONSE REGULATOR receiver
C4597_05620	COG2017	converts alpha-aldose to the beta-anomer
C4597_05625	COG0166	Belongs to the GPI family
C4597_05635	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
C4597_05640	COG1302	Protein conserved in bacteria
C4597_05650	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
C4597_05655	COG0291	Belongs to the bacterial ribosomal protein bL35 family
C4597_05660	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
C4597_05675	COG0049	tRNA binding
C4597_05680	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C4597_05685	COG3842	ATPase activity
C4597_05695	COG1177	transmembrane transport
C4597_05700	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
C4597_05705	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C4597_05725	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
C4597_05730	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
C4597_05740	COG0492	ferredoxin-NADP+ reductase activity
C4597_05760	COG0149	triose-phosphate isomerase activity
C4597_05800	COG0126	phosphoglycerate kinase activity
C4597_05815	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
C4597_05825	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
C4597_05830	COG1713	HD superfamily hydrolase involved in NAD metabolism
C4597_05835	COG0799	negative regulation of ribosome biogenesis
C4597_05840	COG2226	methyltransferase
C4597_05845	COG1323	Belongs to the UPF0348 family
C4597_05855	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
C4597_05860	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
C4597_05865	COG0488	(ABC) transporter
C4597_05870	COG2137	regulation of response to DNA damage stimulus
C4597_05940	COG0582	viral genome integration into host DNA
C4597_05945	COG3557	Belongs to the UPF0374 family
C4597_05955	COG0436	Aminotransferase
C4597_05960	COG4684	Psort location CytoplasmicMembrane, score
C4597_05965	COG1970	mechanosensitive ion channel activity
C4597_05970	COG2759	Belongs to the formate--tetrahydrofolate ligase family
C4597_05975	COG1418	mRNA catabolic process
C4597_05980	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
C4597_05985	COG0459	protein refolding
C4597_05995	COG4720	Psort location CytoplasmicMembrane, score
C4597_06000	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
C4597_06005	COG4807	Protein conserved in bacteria
C4597_06010	COG0716	FMN binding
C4597_06015	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C4597_06025	COG1122	ATPase activity
C4597_06035	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C4597_06040	COG0667	Aldo Keto reductase
C4597_06045	COG0561	phosphatase activity
C4597_06055	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C4597_06065	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C4597_06070	COG1597	lipid kinase activity
C4597_06080	COG2706	6-phosphogluconolactonase activity
C4597_06085	COG0628	permease
C4597_06090	COG0586	Pfam SNARE associated Golgi protein
C4597_06095	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C4597_06210	COG1705	Flagellar rod assembly protein muramidase FlgJ
C4597_06225	COG1278	Cold shock
C4597_06240	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C4597_06245	COG0779	Required for maturation of 30S ribosomal subunits
C4597_06250	COG0195	Participates in both transcription termination and antitermination
C4597_06255	COG2740	Nucleic-acid-binding protein implicated in transcription termination
C4597_06265	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
C4597_06270	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
C4597_06275	COG1674	ftsk spoiiie
C4597_06305	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C4597_06315	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
C4597_06320	COG0218	Necessary for normal cell division and for the maintenance of normal septation
C4597_06335	COG1193	negative regulation of DNA recombination
C4597_06340	COG0656	L-ascorbic acid biosynthetic process
C4597_06350	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C4597_06355	COG3425	synthase
C4597_06365	COG0860	N-Acetylmuramoyl-L-alanine amidase
C4597_06370	COG0124	histidyl-tRNA synthetase
C4597_06375	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
C4597_06380	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C4597_06385	COG0828	Belongs to the bacterial ribosomal protein bS21 family
C4597_06390	COG1610	YqeY-like protein
C4597_06395	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
C4597_06400	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
C4597_06405	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
C4597_06410	COG1381	Involved in DNA repair and RecF pathway recombination
C4597_06420	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
C4597_06425	COG0196	riboflavin kinase activity
C4597_06435	COG1388	LysM domain
C4597_06435	COG1134	teichoic acid transport
C4597_06440	COG1682	transport, permease protein
C4597_06455	COG2610	gluconate transmembrane transporter activity
C4597_06460	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C4597_06465	COG0612	Peptidase, M16
C4597_06470	COG0612	Peptidase, M16
C4597_06475	COG1426	Protein conserved in bacteria
C4597_06480	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C4597_06485	COG1546	Belongs to the CinA family
C4597_06485	COG1058	Belongs to the CinA family
C4597_06490	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
C4597_06505	COG0024	Methionine aminopeptidase
C4597_06510	COG1719	4-vinyl reductase, 4VR
C4597_06520	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
C4597_06525	COG1234	tRNA 3'-trailer cleavage
C4597_06530	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
C4597_06530	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
C4597_06540	COG4224	UPF0291 protein
C4597_06545	COG3763	UPF0154 protein
C4597_06550	COG0204	Acyl-transferase
C4597_06555	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
C4597_06560	COG2827	Endonuclease containing a URI domain
C4597_06565	COG0052	Belongs to the universal ribosomal protein uS2 family
C4597_06570	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
C4597_06575	COG0528	UMP kinase activity
C4597_06585	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C4597_06590	COG1428	Deoxynucleoside kinase
C4597_06595	COG0546	phosphoglycolate phosphatase activity
C4597_06605	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
C4597_06620	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
C4597_06635	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C4597_06640	COG0617	tRNA 3'-terminal CCA addition
C4597_06645	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C4597_06660	COG4862	establishment of competence for transformation
C4597_06670	COG1164	Oligoendopeptidase f
C4597_06675	COG0752	glycyl-tRNA synthetase alpha subunit
C4597_06680	COG0751	glycine-tRNA ligase activity
C4597_06695	COG2814	Major facilitator Superfamily
C4597_06705	COG0765	amino acid transport
C4597_06710	COG1126	abc transporter atp-binding protein
C4597_06715	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4597_06720	COG2814	Major facilitator Superfamily
C4597_06730	COG3331	DNA recombination
C4597_06735	COG4474	Belongs to the UPF0398 family
C4597_06750	COG0116	Belongs to the methyltransferase superfamily
C4597_06760	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C4597_06780	COG1132	(ABC) transporter
C4597_06785	COG0556	nucleotide-excision repair
C4597_06795	COG0564	pseudouridine synthase activity
C4597_06800	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
C4597_06805	COG0505	Belongs to the CarA family
C4597_06815	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C4597_06840	COG1304	FMN binding
C4597_06860	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C4597_06860	COG1199	ATP-dependent helicase activity
C4597_06870	COG0017	Asparaginyl-tRNA synthetase
C4597_06875	COG0488	(ABC) transporter
C4597_06890	COG0587	DNA-directed DNA polymerase activity
C4597_06895	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C4597_06905	COG2996	Protein conserved in bacteria
C4597_06915	COG1187	pseudouridine synthase activity
C4597_06925	COG0514	ATP-dependent DNA helicase (RecQ)
C4597_06935	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
C4597_06940	COG0539	negative regulation of cytoplasmic translation
C4597_06945	COG1160	GTP binding
C4597_06955	COG4975	Glucose uptake
C4597_06960	COG0561	phosphatase activity
C4597_06965	COG0095	Lipoate-protein ligase
C4597_06995	COG1316	TRANSCRIPTIONal
C4597_07005	COG0489	protein tyrosine kinase activity
C4597_07010	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C4597_07025	COG0583	DNA-binding transcription factor activity
C4597_07030	COG2855	membrane
C4597_07035	COG2199	diguanylate cyclase activity
C4597_07040	COG0791	NLP P60 protein
C4597_07040	COG3883	PFAM NLP P60 protein
C4597_07055	COG0358	DNA primase activity
C4597_07060	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C4597_07065	COG1420	regulation of RNA biosynthetic process
C4597_07070	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
C4597_07075	COG0443	Heat shock 70 kDa protein
C4597_07080	COG0484	heat shock protein binding
C4597_07100	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C4597_07105	COG2211	Major facilitator Superfamily
C4597_07110	COG0745	RESPONSE REGULATOR receiver
C4597_07115	COG5002	protein histidine kinase activity
C4597_07120	COG0572	uridine kinase
C4597_07125	COG1363	Peptidase, m42
C4597_07130	COG0072	phenylalanine-tRNA ligase activity
C4597_07130	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C4597_07145	COG0670	Belongs to the BI1 family
C4597_07175	COG3706	GGDEF domain
C4597_07180	COG0583	DNA-binding transcription factor activity
C4597_07200	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C4597_07220	COG3479	Phenolic acid decarboxylase
C4597_07225	COG1695	Transcriptional regulator
C4597_07230	COG0028	Belongs to the TPP enzyme family
C4597_07235	COG0653	protein targeting
C4597_07250	COG1073	alpha beta
C4597_07290	COG2918	glutathione biosynthetic process
C4597_07290	COG1181	Belongs to the D-alanine--D-alanine ligase family
C4597_07315	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C4597_07320	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
C4597_07325	COG2217	Heavy metal translocating P-type atpase
C4597_07355	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C4597_07370	COG0783	Belongs to the Dps family
C4597_07395	COG1063	alcohol dehydrogenase
C4597_07505	COG1715	Restriction endonuclease
C4597_07510	COG0783	Belongs to the Dps family
C4597_07555	COG3620	sequence-specific DNA binding