locus-tag	class	description
CO680_00005	ENOG4108IIJ	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
CO680_00010	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
CO680_00015	ENOG4107QW4	alcohol dehydrogenase
CO680_00020	ENOG4105DHI	Methyltransferase
CO680_00040	ENOG41067S9	phage shock protein C, PspC
CO680_00050	ENOG4107QNK	)-transporter
CO680_00060	ENOG4105C5H	ABC transporter
CO680_00070	ENOG4107Y49	methyltransferase
CO680_00085	ENOG4105C6E	dna polymerase iii
CO680_00090	ENOG410816I	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity)
CO680_00095	ENOG4105F3K	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity)
CO680_00105	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
CO680_00110	ENOG4105X0R	protein from nitrogen regulatory protein P-II
CO680_00120	ENOG4105CU0	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity)
CO680_00130	ENOG4105CMR	udp-glucose 4-epimerase
CO680_00135	ENOG41072GX	Peptidase M22 Glycoprotease
CO680_00150	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
CO680_00155	ENOG4105EAH	synthase
CO680_00160	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
CO680_00165	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
CO680_00170	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
CO680_00175	ENOG41080UE	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
CO680_00180	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CO680_00190	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
CO680_00195	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
CO680_00200	ENOG4108R70	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity)
CO680_00205	ENOG41082SA	50s ribosomal protein l29
CO680_00210	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
CO680_00215	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
CO680_00220	ENOG4105KAR	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity)
CO680_00225	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CO680_00230	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
CO680_00235	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
CO680_00245	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
CO680_00250	ENOG4105VPB	50S ribosomal protein L30
CO680_00255	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
CO680_00260	ENOG4105CGG	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity)
CO680_00270	ENOG4105K9U	however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)
CO680_00280	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CO680_00285	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
CO680_00290	ENOG4105CTF	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
CO680_00315	ENOG4108UMI	ABC transporter, permease
CO680_00320	ENOG4108JEI	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity)
CO680_00325	ENOG4105D01	(LipO)protein
CO680_00335	ENOG4105DAP	Nicotinate phosphoribosyltransferase
CO680_00340	ENOG4107RA1	nh(3)-dependent nad( ) synthetase
CO680_00350	ENOG4105DQ6	Transposase
CO680_00355	ENOG4105CPC	Aldo Keto reductase
CO680_00360	ENOG4105C8N	cysteinyl-tRNA synthetase
CO680_00365	ENOG4106762	Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity)
CO680_00370	ENOG4105CXR	Phospho-2-dehydro-3-deoxyoctonate aldolase
CO680_00375	ENOG4105C2X	Arabinose 5-phosphate isomerase
CO680_00380	ENOG4105CXT	aspartate transcarbamylase
CO680_00385	ENOG4105CD3	dihydroorotase
CO680_00390	ENOG4105C1M	carbamoyl-phosphate synthetase glutamine chain
CO680_00395	ENOG4105CU6	carbamoyl-phosphate synthetase ammonia chain
CO680_00400	ENOG4107RY0	Catalyzes the conversion of dihydroorotate to orotate (By similarity)
CO680_00405	ENOG4106EG9	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity)
CO680_00410	ENOG41065E1	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
CO680_00415	ENOG4105KEB	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
CO680_00420	ENOG4105C2N	RNA methyltransferase TrmH family group 3
CO680_00430	ENOG4107FTN	50S ribosomal protein L33
CO680_00440	ENOG4105E5V	Participates in transcription elongation, termination and antitermination (By similarity)
CO680_00445	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
CO680_00450	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
CO680_00455	ENOG4108VZM	50s ribosomal protein L10
CO680_00460	ENOG4105KBC	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
CO680_00470	ENOG4105DIK	(ABC) transporter
CO680_00475	ENOG4105CC5	ABC transporter
CO680_00480	ENOG4105DSE	periplasmic solute binding protein
CO680_00495	ENOG4108JJB	ABC transporter
CO680_00500	ENOG4108JJB	ABC transporter
CO680_00505	ENOG4105EK6	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity)
CO680_00510	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
CO680_00515	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
CO680_00520	ENOG4108UJD	30S ribosomal protein S9
CO680_00555	ENOG4105EZV	Transcriptional regulator
CO680_00575	ENOG4105CSH	Transporter
CO680_00585	ENOG4105E66	phosphoriboisomerase A
CO680_00600	ENOG4105DU0	nucleoside hydrolase
CO680_00610	ENOG4107RHR	regulatoR
CO680_00640	ENOG4105CVA	phosphate
CO680_00660	ENOG4105K85	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity)
CO680_00665	ENOG4105CPC	Aldo Keto reductase
CO680_00670	ENOG4108X79	transcriptional regulator
CO680_00675	ENOG4105FCI	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity)
CO680_00680	ENOG4108XCU	pts system
CO680_00685	ENOG4108EQA	pts system
CO680_00690	ENOG4105ETZ	PTS System
CO680_00705	ENOG4105CMG	Carbohydrate kinase
CO680_00725	ENOG4105DT3	PTS system, galactitol-specific IIc component
CO680_00740	ENOG4108RG0	uracil-dna glycosylase
CO680_00765	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
CO680_00775	ENOG4105C21	Displays ATPase and GTPase activities (By similarity)
CO680_00780	ENOG4105CHW	UPF0052 protein
CO680_00785	ENOG4105CIE	May be required for sporulation (By similarity)
CO680_00790	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
CO680_00830	ENOG4107FQX	Alpha-acetolactate decarboxylase
CO680_00835	ENOG4105CIS	alcohol dehydrogenase
CO680_00840	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
CO680_00845	ENOG41068JE	domain protein
CO680_00860	ENOG4107Z0P	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity)
CO680_00870	ENOG4105CTP	PilT protein domain protein
CO680_00875	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
CO680_00880	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
CO680_00885	ENOG4105CG1	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity)
CO680_00895	ENOG4108RWN	rrna methyltransferase
CO680_00905	ENOG4105CZM	Major Facilitator
CO680_00915	ENOG4105CSS	phenylalanyl-tRNA synthetase (alpha subunit)
CO680_00920	ENOG4105C6A	phenylalanyl-tRNA synthetase (beta subunit)
CO680_00930	ENOG4105C9U	ATP-dependent DNA helicase RecQ
CO680_00935	ENOG4108UKH	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
CO680_00945	ENOG4107RF6	penicillin-binding protein
CO680_00950	ENOG4105MK2	5-formyltetrahydrofolate cyclo-ligase
CO680_00965	ENOG4105DKQ	ROK family
CO680_00970	ENOG4105VRS	hydrolase family 18
CO680_00975	ENOG4107YZP	Rhodanese domain protein
CO680_00985	ENOG4108QXE	glycerophosphoryl diester phosphodiesterase
CO680_00995	ENOG4105KV4	Transcriptional regulator
CO680_01000	ENOG4105C5F	glutamine synthetase
CO680_01030	ENOG4105K46	50S ribosomal protein l27
CO680_01040	ENOG4105DZR	Type I site-specific deoxyribonuclease
CO680_01080	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
CO680_01115	ENOG4107WD8	ABC transporter, permease
CO680_01120	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
CO680_01125	ENOG4106AF1	UPF0344 protein
CO680_01135	ENOG4105E4F	Isochorismate synthase
CO680_01140	ENOG4105C4A	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity)
CO680_01150	ENOG4105DTQ	mandelate racemase muconate lactonizing
CO680_01155	ENOG4105DC7	peptidase M24
CO680_01170	ENOG4107R8B	5'-nucleotidase
CO680_01175	ENOG4105MMD	transcriptional regulator
CO680_01180	ENOG4105D4U	had-superfamily hydrolase, subfamily iia
CO680_01190	ENOG4105CVA	phosphate
CO680_01195	ENOG4105C8U	phosphate abc transporter
CO680_01200	ENOG4105E2Z	phosphate ABC transporter (Permease
CO680_01205	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
CO680_01210	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
CO680_01215	ENOG4108UTW	Plays a role in the regulation of phosphate uptake
CO680_01220	ENOG410902V	Modulates RecA activity (By similarity)
CO680_01230	ENOG4105C8A	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity)
CO680_01240	ENOG4108JZF	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity)
CO680_01250	ENOG4105D1H	recombination factor protein RarA
CO680_01260	ENOG4107YZX	Universal stress protein
CO680_01275	ENOG4108UT2	hemolysin iii
CO680_01285	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
CO680_01290	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
CO680_01295	ENOG4105C5H	ABC transporter
CO680_01300	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
CO680_01305	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
CO680_01310	ENOG4105C0X	amino acid
CO680_01325	ENOG4108WJV	had superfamily (subfamily IIIa) phosphatase
CO680_01330	ENOG4105CQW	ribosome biogenesis GTPase YqeH
CO680_01340	ENOG4108Z1W	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity)
CO680_01345	ENOG4108WF2	Metal Dependent Phosphohydrolase
CO680_01350	ENOG4105KEM	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity)
CO680_01360	ENOG4105CDE	UPF0348 protein
CO680_01370	ENOG4105D86	that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity)
CO680_01375	ENOG4105DC6	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity)
CO680_01385	ENOG4105C22	threonyL-tRNA synthetase
CO680_01390	ENOG4105CKA	Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity)
CO680_01400	ENOG4108V7D	UPF0397 protein
CO680_01405	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
CO680_01410	ENOG4105DVS	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
CO680_01415	ENOG41067QG	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
CO680_01425	ENOG4105DX0	Hemolysin A
CO680_01430	ENOG4105XBY	Regulates arginine biosynthesis genes (By similarity)
CO680_01435	ENOG4105C4F	May be involved in recombinational repair of damaged DNA (By similarity)
CO680_01440	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
CO680_01445	ENOG4105ZAD	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity)
CO680_01450	ENOG4105DQR	SNARE associated Golgi
CO680_01460	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
CO680_01570	ENOG4105C5I	Dehydrogenase
CO680_01575	ENOG4105C4M	(Ubiquinol oxidase) subunit I
CO680_01580	ENOG4105CFY	cytochrome d ubiquinol oxidase, subunit ii
CO680_01585	ENOG4108JJ9	ABC, transporter
CO680_01590	ENOG4108JJ8	(ABC) transporter
CO680_01595	ENOG4108ZW7	flagellar rod assembly protein muramidase flgj
CO680_01615	ENOG4105VEQ	Cold shock protein
CO680_01620	ENOG4108YZ4	nudix hydrolase
CO680_01630	ENOG4105DUF	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity)
CO680_01660	ENOG4105WAZ	(Glutaredoxin-like protein) NrdH
CO680_01665	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
CO680_01680	ENOG4105C7J	ABC transporter, permease
CO680_01685	ENOG4108JEI	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity)
CO680_01690	ENOG4105WMR	Protein CrcB homolog
CO680_01695	ENOG41082CG	Protein CrcB homolog
CO680_01710	ENOG4105W5Q	DNA repair protein (RadC
CO680_01715	ENOG4105DFF	Rod shape-determining protein mreb
CO680_01720	ENOG4105N3I	Involved in formation and maintenance of cell shape (By similarity)
CO680_01735	ENOG4105E5Q	amino acid AbC transporter
CO680_01740	ENOG4105CDA	abc transporter atp-binding protein
CO680_01745	ENOG4105EAB	amino acid AbC transporter
CO680_01750	ENOG4105CKU	formyltetrahydrofolate synthetase
CO680_01760	ENOG4108IQI	permease
CO680_01765	ENOG4105CA9	Pyruvate kinase
CO680_01770	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
CO680_01775	ENOG4107TVK	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity)
CO680_01785	ENOG4108V6E	Cell division protein mraZ
CO680_01790	ENOG4105CGJ	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity)
CO680_01800	ENOG4105CJN	penicillin-binding protein
CO680_01805	ENOG4105CPY	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity)
CO680_01810	ENOG4105DMZ	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity)
CO680_01820	ENOG41087KY	Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity)
CO680_01825	ENOG4105CIT	This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity)
CO680_01835	ENOG4105VR5	Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity)
CO680_01840	ENOG41067XK	integral membrane protein
CO680_01855	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
CO680_01860	ENOG4107RPC	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
CO680_01870	ENOG4105C7H	Helicase, RecD TraA family
CO680_01875	ENOG4105CDY	transcriptional regulatory protein
CO680_01880	ENOG4105C7N	Xanthine uracil vitamin C permease
CO680_01920	ENOG4105C25	Primosomal protein n'
CO680_01925	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
CO680_01930	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
CO680_01935	ENOG4108ZF3	Phosphatase
CO680_01940	ENOG4105D9P	serine threonine protein kinase
CO680_01945	ENOG4105E06	May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity)
CO680_01950	ENOG4105DJV	ribulose-phosphate 3-epimerase
CO680_01955	ENOG4105FJ0	thiamine
CO680_01960	ENOG4105VB9	50S ribosomal protein l28
CO680_01970	ENOG4105DP4	dak2 domain fusion protein ylov
CO680_01975	ENOG4105CB5	ATP-dependent DNA helicase recG
CO680_01980	ENOG4105C6B	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity)
CO680_01985	ENOG4105VNB	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
CO680_01990	ENOG4108ZBM	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity)
CO680_01995	ENOG4105CDB	Required for chromosome condensation and partitioning (By similarity)
CO680_02000	ENOG4105CCP	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
CO680_02010	ENOG4105CB9	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CO680_02015	ENOG4105K5M	30s ribosomal protein S16
CO680_02020	ENOG4105DKJ	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
CO680_02025	ENOG4107Z8R	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity)
CO680_02030	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
CO680_02035	ENOG4108YY1	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity)
CO680_02045	ENOG4107AYK	membrAne
CO680_02050	ENOG41069HH	4-oxalocrotonate tautomerase
CO680_02055	ENOG4108HMR	Key enzyme in the regulation of glycerol uptake and metabolism (By similarity)
CO680_02060	ENOG4107SN7	NLP P60 protein
CO680_02065	ENOG4105ZMH	deoxynucleoside kinase
CO680_02070	ENOG4105M2E	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity)
CO680_02075	ENOG410667J	hydrolase
CO680_02100	ENOG4105EYG	tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity)
CO680_02120	ENOG4108IMY	Transcriptional regulator
CO680_02130	ENOG4106050	phage regulatory protein, rha family
CO680_02195	ENOG4108UUM	single-stranded DNA-binding protein
CO680_02250	ENOG4107BMA	Transglycosylase associated protein
CO680_02270	ENOG4108TFU	terminase (Small subunit)
CO680_02275	ENOG4105IG6	Phage terminase, large subunit
CO680_02380	ENOG4108VY7	phosphate-starvation-inducible protein PsiE
CO680_02390	ENOG4105CDW	Resistance protein
CO680_02395	ENOG41090SU	Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity)
CO680_02400	ENOG4108SQ7	Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis
CO680_02410	ENOG4105DPN	Oligoendopeptidase f
CO680_02425	ENOG4105DC7	peptidase M24
CO680_02430	ENOG4105ETE	Transcriptional regulator (LacI family
CO680_02435	ENOG4105CUB	amino acid
CO680_02440	ENOG4108JPW	Aminotransferase
CO680_02445	ENOG4107FQX	Alpha-acetolactate decarboxylase
CO680_02465	ENOG4105CJS	Phosphopantothenoylcysteine decarboxylase
CO680_02470	ENOG4105F99	Hydroxymethylglutaryl-CoA synthase
CO680_02480	ENOG4105C5C	n-acetylmuramoyl-l-alanine amidase
CO680_02485	ENOG4105CUT	histidyl-tRNA synthetase
CO680_02490	ENOG4105C9M	aspartyl-trna synthetase
CO680_02495	ENOG4107AYK	membrAne
CO680_02500	ENOG4105VCC	30S ribosomal protein S21
CO680_02505	ENOG4105KTH	gatB Yqey
CO680_02510	ENOG4105C9A	Phoh family
CO680_02515	ENOG4105KGE	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity)
CO680_02525	ENOG4105CWT	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity)
CO680_02535	ENOG4108HMW	glycyl-tRNA synthetase, alpha subunit
CO680_02540	ENOG4105C38	Glycyl-tRNA synthetase beta subunit
CO680_02545	ENOG4105DU1	integral membrane protein, terc
CO680_02550	ENOG4105HHQ	6-phosphogluconolactonase (EC 3.1.1.31)
CO680_02560	ENOG4108UIQ	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity)
CO680_02565	ENOG4105CNU	cell division protein FtsK
CO680_02570	ENOG4108IUX	(ABC) transporter
CO680_02575	ENOG4105RHA	ABC transporter, permease
CO680_02580	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
CO680_02585	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CO680_02590	ENOG4108ZK7	protein family UPF0029, Impact, N-terminal protein
CO680_02605	ENOG4105KA4	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity)
CO680_02615	ENOG4105E2N	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity)
CO680_02650	ENOG4105C6U	Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity)
CO680_02660	ENOG4105CQ3	Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity)
CO680_02665	ENOG4105SFS	phosphoesterase RecJ domain protein
CO680_02670	ENOG4105C1J	atp-dependent rna helicase
CO680_02675	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
CO680_02680	ENOG4105VBH	UPF0297 protein
CO680_02685	ENOG4108Z08	Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity)
CO680_02690	ENOG4105VPH	UPF0473 protein
CO680_02695	ENOG4105VPH	UPF0473 protein
CO680_02705	ENOG4105EGY	DNA internalization-related competence protein ComEC Rec2
CO680_02710	ENOG4105TQK	DNA polymerase iii, delta' subunit
CO680_02715	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
CO680_02720	ENOG4105KQV	Binds directly to 16S ribosomal RNA (By similarity)
CO680_02735	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
CO680_02745	ENOG4105CHN	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
CO680_02750	ENOG4105WHM	Necessary for normal cell division and for the maintenance of normal septation (By similarity)
CO680_02765	ENOG4105C98	muts2 protein
CO680_02770	ENOG4105K63	Thioredoxin
CO680_02825	ENOG4107XGZ	Hydrolase
CO680_02835	ENOG4108V82	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
CO680_02855	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
CO680_02860	ENOG4105EMS	pseudouridine synthase
CO680_02865	ENOG4105CJW	magnesium transporter
CO680_02870	ENOG4105K7D	Required for maturation of 30S ribosomal subunits (By similarity)
CO680_02875	ENOG4105CHV	Transcription elongation factor NusA
CO680_02880	ENOG4105VZN	Nucleic-acid-binding protein implicated in transcription termination
CO680_02890	ENOG4107EEM	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
CO680_02895	ENOG4105KG7	Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity)
CO680_02900	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
CO680_02905	ENOG4105DTN	riboflavin biosynthesis protein ribF
CO680_02910	ENOG4105F23	Fibronectin-binding protein
CO680_02915	ENOG4106N3A	copper homeostasis protein cutc
CO680_02925	ENOG4105EPR	degv family
CO680_02930	ENOG4108RCR	degv family
CO680_02935	ENOG41090WU	lipolytic protein G-D-S-L family
CO680_02945	ENOG4105VSD	UPF0346 protein
CO680_02950	ENOG4105C9W	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity)
CO680_02955	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
CO680_02960	ENOG4105C79	DNA protecting protein DprA
CO680_02965	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
CO680_02970	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
CO680_02980	ENOG4105K7Z	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity)
CO680_02985	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
CO680_02995	ENOG4105E2M	Manganese-dependent inorganic pyrophosphatase
CO680_03005	ENOG4108IJ7	Glycine betaine
CO680_03020	ENOG4107QMW	pyridine nucleotide-disulfide oxidoreductase
CO680_03025	ENOG4105D01	(LipO)protein
CO680_03030	ENOG4108HW8	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity)
CO680_03055	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
CO680_03065	ENOG4105ECY	inositol monophosphatase
CO680_03070	ENOG4105CI3	gtp-binding protein typa
CO680_03075	ENOG4105CNI	cell division protein FtsW
CO680_03080	ENOG4105WUC	UPF0298 protein
CO680_03085	ENOG4106H78	methyltransferase
CO680_03090	ENOG4108ZEF	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)
CO680_03095	ENOG41063PX	domain protein
CO680_03100	ENOG4105DF9	Lipoate-protein, ligase
CO680_03105	ENOG4107RUY	(E1 component), alpha subunit
CO680_03115	ENOG4105C7S	Dehydrogenase
CO680_03120	ENOG4107QN2	dihydrolipoyl dehydrogenase
CO680_03125	ENOG41081E8	Alpha beta hydrolase
CO680_03130	ENOG4108J59	Extracellular solute-binding protein, family 5
CO680_03135	ENOG4105CEA	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity)
CO680_03140	ENOG4105CA1	Removes the N-terminal methionine from nascent proteins (By similarity)
CO680_03145	ENOG4105C5Y	PTS System
CO680_03150	ENOG4108HKT	sucrose-6-phosphate hydrolase
CO680_03155	ENOG4105ETE	Transcriptional regulator (LacI family
CO680_03160	ENOG4107414	GntR family transcriptional regulator
CO680_03170	ENOG4105C5Y	PTS System
CO680_03175	ENOG4105C71	hydrolase family 65, central catalytic
CO680_03180	ENOG4107URF	beta-phospho-glucomutase
CO680_03185	ENOG4105CUB	amino acid
CO680_03235	ENOG4105DQ6	Transposase
CO680_03260	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
CO680_03265	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
CO680_03280	ENOG4105DPZ	Two component transcriptional regulator (Winged helix family
CO680_03285	ENOG4105BZU	Histidine kinase
CO680_03290	ENOG4105DBI	uridine monophosphokinase
CO680_03295	ENOG4105CN9	Peptidase m42 family protein
CO680_03300	ENOG4108VDD	TRNA binding domain protein
CO680_03310	ENOG4105DFU	Cell wall formation (By similarity)
CO680_03315	ENOG4105HFZ	Membrane
CO680_03320	ENOG4105C2M	dna polymerase I
CO680_03345	ENOG4107BMA	Transglycosylase associated protein
CO680_03375	ENOG4105I2S	Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity)
CO680_03385	ENOG4105K56	Transcriptional regulator
CO680_03390	ENOG4107QN2	dihydrolipoyl dehydrogenase
CO680_03395	ENOG4105CIS	alcohol dehydrogenase
CO680_03400	ENOG4105KA3	membrAne
CO680_03405	ENOG4105ERD	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity)
CO680_03410	ENOG4108ZQD	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity)
CO680_03435	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
CO680_03440	ENOG4105GR3	Histidine kinase
CO680_03450	ENOG4107XQC	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins (By similarity)
CO680_03455	ENOG41064MX	Tetr family transcriptional regulator
CO680_03460	ENOG4106UJV	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity)
CO680_03475	ENOG4105CRD	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity)
CO680_03480	ENOG4105DVT	helicase
CO680_03490	ENOG4105C5S	asparaginyl-tRNA synthetase
CO680_03525	ENOG4105BZ4	penicillin-binding protein
CO680_03530	ENOG4108UI2	Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity)
CO680_03535	ENOG4108UKS	UPF0398 protein
CO680_03540	ENOG4105XWG	Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation (By similarity)
CO680_03550	ENOG4105C4H	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity)
CO680_03555	ENOG4105C4R	Atp-dependent dna helicase
CO680_03560	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
CO680_03575	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
CO680_03580	ENOG4105DUX	Transporter
CO680_03590	ENOG4105K59	histidine triad (HIT) protein
CO680_03605	ENOG4105CZ1	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity)
CO680_03630	ENOG4105DWF	phosphomethylpyrimidine kinase
CO680_03645	ENOG4105FCD	Major Facilitator
CO680_03655	ENOG4105CG3	alpha amylase, catalytic region
CO680_03675	ENOG4105DQ6	Transposase
CO680_03715	ENOG4108IMY	Transcriptional regulator
CO680_03795	ENOG4105DQ6	Transposase
CO680_03830	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
CO680_03845	ENOG4107BMA	Transglycosylase associated protein
CO680_03885	ENOG4105NA0	Transcriptional regulator
CO680_03905	ENOG4107URF	beta-phospho-glucomutase
CO680_03910	ENOG4105ENN	converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity)
CO680_03960	ENOG4107ZGM	malolactic fermentation system
CO680_03965	ENOG4105C6K	Malic enzyme
CO680_04000	ENOG4105E09	nadh pyrophosphatase
CO680_04005	ENOG4105C26	Dehydrogenase
CO680_04035	ENOG4105WH5	Teichoic acid glycosylation protein
CO680_04040	ENOG41090U3	tautomerase
CO680_04045	ENOG4105D1Q	UPF0246 protein
CO680_04055	ENOG4105D01	(LipO)protein
CO680_04070	ENOG4108K79	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
CO680_04095	ENOG4107Y70	Heat shock protein
CO680_04105	ENOG4105EXC	Acyl-transferase
CO680_04115	ENOG4105CXG	d-lactate dehydrogenase
CO680_04120	ENOG4105C5I	Dehydrogenase
CO680_04140	ENOG4105DME	alpha-galactosidase
CO680_04145	ENOG4107RBJ	symporter
CO680_04155	ENOG4106KNP	GTP-binding protein LepA C-terminus
CO680_04160	ENOG410807C	QueT transporter
CO680_04175	ENOG4108J59	Extracellular solute-binding protein, family 5
CO680_04180	ENOG4105DC8	reductase
CO680_04190	ENOG4105CKN	UDP-glucose-hexose-1-phosphate uridylyltransferase
CO680_04195	ENOG4105CRD	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity)
CO680_04200	ENOG4107RBJ	symporter
CO680_04205	ENOG4108BRW	Activates expression of the rhaSR operon in response to L-rhamnose (By similarity)
CO680_04225	ENOG41082QR	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
CO680_04240	ENOG4108JIJ	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity)
CO680_04250	ENOG4105D42	Cleaves the N-terminal amino acid of tripeptides (By similarity)
CO680_04255	ENOG4105EGD	dinuclear metal center protein, YbgI family
CO680_04265	ENOG41068YB	TPR repeat-containing protein
CO680_04280	ENOG4105EYH	Exonuclease
CO680_04285	ENOG4107RFY	SbcCD D subunit
CO680_04290	ENOG4105PUK	Membrane
CO680_04295	ENOG4105DWF	phosphomethylpyrimidine kinase
CO680_04300	ENOG4105K70	DNA-binding protein
CO680_04305	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
CO680_04310	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
CO680_04315	ENOG4105CAT	Cytidine monophosphate kinase
CO680_04320	ENOG4105DQ6	Transposase
CO680_04335	ENOG4105C9U	ATP-dependent DNA helicase RecQ
CO680_04345	ENOG4108SAX	Membrane
CO680_04350	ENOG4105FE9	pseudouridine synthase
CO680_04355	ENOG4105K8I	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity)
CO680_04360	ENOG4108KVX	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity)
CO680_04375	ENOG4105QNR	S1 RNA binding domain protein
CO680_04385	ENOG4107RWR	Sodium hydrogen exchanger
CO680_04395	ENOG4108YYA	Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity)
CO680_04400	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
CO680_04405	ENOG4105C0B	DNA polymerase III (alpha subunit)
CO680_04420	ENOG4105C5H	ABC transporter
CO680_04435	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
CO680_04440	ENOG4105BZU	Histidine kinase
CO680_04445	ENOG4108KGH	TRANSCRIPTIONal
CO680_04455	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
CO680_04460	ENOG4105CU7	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity)
CO680_04465	ENOG4105DQ6	Transposase
CO680_04475	ENOG4105CE9	30S ribosomal protein S2
CO680_04480	ENOG4105VC4	domain protein
CO680_04485	ENOG41060K3	Methyltransferase
CO680_04490	ENOG4105F6E	Acyl-transferase
CO680_04495	ENOG4105VXM	UPF0154 protein
CO680_04500	ENOG4105VPS	UPF0291 protein
CO680_04505	ENOG4105DS7	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity)
CO680_04510	ENOG4105KT7	mgtC SapB transporter
CO680_04515	ENOG4108UW5	maltose o-acetyltransferase
CO680_04535	ENOG4109003	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity)
CO680_04540	ENOG4105C2R	Single-stranded-DNA-specific exonuclease (RecJ)
CO680_04560	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
CO680_04565	ENOG4105CFG	Acts as a chaperone (By similarity)
CO680_04570	ENOG4105K90	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CO680_04575	ENOG4105CI8	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity)
CO680_04600	ENOG4108RJ9	Glycosyl transferase, family 2
CO680_04605	ENOG4105CKK	Glycosyl transferase, family 2
CO680_04625	ENOG4105D5D	udp-galactopyranose mutase
CO680_04645	ENOG4105D3Q	Sugar transferase
CO680_04650	ENOG4105CA1	Removes the N-terminal methionine from nascent proteins (By similarity)
CO680_04700	ENOG4105CS2	ec 3.2.1.21
CO680_04705	ENOG4108S3Y	transcriptional regulator
CO680_04710	ENOG410667J	hydrolase
CO680_04745	ENOG4107RXY	Glycosyl transferase
CO680_04760	ENOG4107ZIC	Glycerol-3-phosphate cytidylyltransferase
CO680_04765	ENOG4107SJB	teichoic acid biosynthesis
CO680_04785	ENOG4105EY8	ABC transporter
CO680_04795	ENOG4105KPE	licD family
CO680_04800	ENOG4108115	UPF0145 protein
CO680_04820	ENOG4105JPG	D-isomer specific 2-hydroxyacid dehydrogenase
CO680_04825	ENOG4105E0X	reductase
CO680_04830	ENOG4108HW8	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity)
CO680_04840	ENOG4105C88	aminopeptidase
CO680_04850	ENOG4108YBP	pseudouridine synthase
CO680_04855	ENOG4105VEQ	Cold shock protein
CO680_04875	ENOG4105CS9	pantothenic acid kinase
CO680_04880	ENOG4105EEM	helicase
CO680_04885	ENOG4105C68	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)
CO680_04890	ENOG4105CEV	competence damage-inducible protein
CO680_04895	ENOG4105BZQ	cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase
CO680_04925	ENOG4108V0P	LemA family
CO680_04935	ENOG410905X	membrane-flanked domain protein
CO680_04940	ENOG4105CMG	Carbohydrate kinase
CO680_04950	ENOG4106D4I	domain protein
CO680_04955	ENOG4107VRP	DNA repair exonuclease
CO680_04960	ENOG4105WZB	UPF0342 protein
CO680_04965	ENOG4105BZ4	penicillin-binding protein
CO680_04970	ENOG4105XBY	Regulates arginine biosynthesis genes (By similarity)
CO680_04975	ENOG4105C75	arginyL-tRNA synthetase
CO680_04985	ENOG4107EEN	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity)
CO680_04995	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
CO680_05000	ENOG4105CBD	Diacylglycerol kinase
CO680_05005	ENOG4105CHT	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
CO680_05010	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
CO680_05015	ENOG4105VB5	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
CO680_05020	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
CO680_05025	ENOG4108KP7	hydrolase
CO680_05030	ENOG4105GYP	Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity)
CO680_05050	ENOG4105C56	H( )-stimulated, divalent metal cation uptake system (By similarity)
CO680_05065	ENOG4105CPC	Aldo Keto reductase
CO680_05070	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
CO680_05075	ENOG4105NSK	ABC superfamily ATP binding cassette transporter membrane protein
CO680_05080	ENOG4108JJB	ABC transporter
CO680_05090	ENOG4105D6T	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity)
CO680_05095	ENOG4108J59	Extracellular solute-binding protein, family 5
CO680_05105	ENOG4105FF2	Type I DHQase
CO680_05110	ENOG4105KHV	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity)
CO680_05115	ENOG4105CMY	5-enolpyruvylshikimate-3-phosphate synthase
CO680_05120	ENOG4105D10	5-enolpyruvylshikimate-3-phosphate phospholyase
CO680_05125	ENOG4105D49	3-dehydroquinate synthase
CO680_05130	ENOG4108JPM	phospho-2-dehydro-3-deoxyheptonate aldolase
CO680_05135	ENOG4105E2X	shikimate dehydrogenase
CO680_05145	ENOG4105CHM	Aminotransferase
CO680_05160	ENOG4105CM3	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity)
CO680_05165	ENOG4105CHM	Aminotransferase
CO680_05170	ENOG4105DUK	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity)
CO680_05175	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
CO680_05180	ENOG4105CH2	amidohydrolase
CO680_05185	ENOG4105DMJ	Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity)
CO680_05190	ENOG4105CU5	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity)
CO680_05195	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
CO680_05200	ENOG4105CFH	Aspartokinase
CO680_05210	ENOG4105ETE	Transcriptional regulator (LacI family
CO680_05225	ENOG4107RPQ	ABC transporter
CO680_05230	ENOG4105FF6	Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity)
CO680_05235	ENOG4105FDU	atp-dependent rna helicase
CO680_05240	ENOG4105EE0	oxidoreductase
CO680_05250	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
CO680_05260	ENOG4108V0P	LemA family
CO680_05270	ENOG4105E66	phosphoriboisomerase A
CO680_05280	ENOG4107QTG	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity)
CO680_05285	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
CO680_05290	ENOG4108YXN	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity)
CO680_05300	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
CO680_05305	ENOG4105CHR	reductase
CO680_05315	ENOG4105EA8	2-Nitropropane dioxygenase
CO680_05320	ENOG410854A	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
CO680_05325	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
CO680_05335	ENOG4108YXN	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity)
CO680_05345	ENOG4105C83	adenylosuccinate lyase
CO680_05350	ENOG4107UUG	Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity)
CO680_05355	ENOG4105CU6	carbamoyl-phosphate synthetase ammonia chain
CO680_05360	ENOG4105C1M	carbamoyl-phosphate synthetase glutamine chain
CO680_05365	ENOG4108UK1	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity)
CO680_05370	ENOG4105C34	Pseudouridine synthase
CO680_05380	ENOG4105VND	Ribonuclease
CO680_05385	ENOG4105DFD	Na H antiporter
CO680_05395	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
CO680_05405	ENOG4105CQX	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity)
CO680_05410	ENOG4105E90	ABC transporter
CO680_05415	ENOG4108IJ8	ABC transporter
CO680_05420	ENOG4108UV6	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity)
CO680_05425	ENOG4105C4U	4-methyl-5-beta-hydroxyethylthiazole kinase
CO680_05435	ENOG4105EGI	Transcriptional regulator
CO680_05440	ENOG4105BZA	Phosphoglycerate kinase
CO680_05445	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
CO680_05560	ENOG4107U9T	Pfam:Ribonuclease_BN
CO680_05585	ENOG4105DQ6	Transposase
CO680_05590	ENOG4105VBF	alkaline shock protein
CO680_05620	ENOG4105CYX	Short-chain dehydrogenase reductase Sdr
CO680_05650	ENOG4105DYT	3-hydroxyacyl-CoA dehydrogenase
CO680_05670	ENOG4107WJM	-acetyltransferase
CO680_05685	ENOG4105VTR	Integrase
CO680_05705	ENOG4105ZT7	DNA-entry nuclease
CO680_05720	ENOG4105F3R	pts system mannose fructose sorbose family iid
CO680_05725	ENOG4105ETZ	PTS System
CO680_05790	ENOG4105E0M	Sulfatase
CO680_05805	ENOG4105W2C	Glycosyl transferase
CO680_05810	ENOG4105BZF	Glycosyl transferase (Group 1
CO680_05820	ENOG4107QJF	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity)
CO680_05825	ENOG4107U5W	ybbr family
CO680_05835	ENOG4107SUZ	Sodium/hydrogen exchanger family
CO680_05840	ENOG4105D4A	Cell wall formation (By similarity)
CO680_05845	ENOG4105DE5	Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity)
CO680_05855	ENOG4105K8N	protein family UPF0079, ATPase
CO680_05865	ENOG4108IJ2	phosphate acetyltransferase
CO680_05870	ENOG4105D5S	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity)
CO680_05880	ENOG4105CDA	abc transporter atp-binding protein
CO680_05885	ENOG4105E5Q	amino acid AbC transporter
CO680_05890	ENOG4108UH4	Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity)
CO680_05895	ENOG4105C40	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity)
CO680_05905	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
CO680_05915	ENOG4105CP7	Triose-phosphate isomerase
CO680_05920	ENOG4108IUK	alpha amylase, catalytic
CO680_05925	ENOG4108IJ9	(ABC) transporter
CO680_05930	ENOG4105EG2	ABC transporter, permease
CO680_05935	ENOG4105D56	permease protein
CO680_05945	ENOG4105CG3	alpha amylase, catalytic region
CO680_05950	ENOG4105BZ3	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity)
CO680_05955	ENOG4105KRI	phosphocarrier protein (HPr
CO680_05965	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
CO680_05970	ENOG4105CVJ	phosphoglycerate mutase
CO680_05975	ENOG4105C3M	thioredoxin reductase
CO680_05980	ENOG4105C3Y	UTP-glucose-1-phosphate uridylyltransferase
CO680_05990	ENOG4105D1C	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity)
CO680_05995	ENOG41086DT	Membrane protein of unknown function
CO680_06005	ENOG4107YZX	Universal stress protein
CO680_06015	ENOG4108R5K	PPIases accelerate the folding of proteins (By similarity)
CO680_06020	ENOG4107RUE	extracellular solute-binding protein family 1
CO680_06025	ENOG4105D38	putrescine abc transporter
CO680_06030	ENOG4105F38	ABC transporter, permease
CO680_06035	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
CO680_06040	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
CO680_06045	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
CO680_06050	ENOG4108UKE	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity)
CO680_06055	ENOG4108YZX	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity)
CO680_06060	ENOG4105VJV	50s ribosomal protein L35
CO680_06065	ENOG4108UUX	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity)
CO680_06070	ENOG4105M7K	Involved in the transcription termination process (By similarity)
CO680_06075	ENOG4108ZSR	alkaline shock protein
CO680_06080	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
CO680_06085	ENOG4107QYV	phosphohexose isomerase
CO680_06090	ENOG4105ENN	converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity)
CO680_06095	ENOG4105CSC	Glucose uptake protein
CO680_06100	ENOG4105BZU	Histidine kinase
CO680_06105	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
CO680_06110	ENOG4105DZC	cytosine deaminase
CO680_06125	ENOG4105D64	Mechanosensitive ion channel
CO680_06130	ENOG4107SJ1	Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity)
CO680_06140	ENOG4105DFH	Transport of potassium into the cell (By similarity)
CO680_06160	ENOG4108MR7	Arylsulfotransferase
CO680_06165	ENOG4105DWR	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity)
CO680_06175	ENOG4105EVU	fructokinase
CO680_06185	ENOG4105C19	ABC transporter
CO680_06195	ENOG4105E4Y	Endoribonuclease that initiates mRNA decay (By similarity)
CO680_06200	ENOG4105C59	p-type ATPase
CO680_06285	ENOG4105C2N	RNA methyltransferase TrmH family group 3
CO680_06290	ENOG4105EWI	Short-chain dehydrogenase reductase Sdr
CO680_06310	ENOG4105DE5	Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity)
CO680_06315	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
CO680_06320	ENOG4105DZP	Membrane-associated zinc metalloprotease
CO680_06325	ENOG4105KNE	Phosphatidate cytidylyltransferase
CO680_06330	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
CO680_06335	ENOG4108HCJ	Hydrolase
CO680_06340	ENOG4105WH5	Teichoic acid glycosylation protein
CO680_06355	ENOG4105PGM	cation diffusion facilitator family transporter
CO680_06360	ENOG4108UGV	hypoxanthine phosphoribosyltransferase
CO680_06375	ENOG4105DGY	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization (By similarity)
CO680_06380	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
CO680_06385	ENOG4105FDP	GntR family transcriptional regulator
CO680_06390	ENOG4105CE4	GlcNAc 6-P deacetylase
CO680_06395	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
CO680_06400	ENOG4105DQF	Hydrolase
CO680_06405	ENOG4105CD8	aminopeptidase N
CO680_06415	ENOG4105II7	pyrroline-5-carboxylate reductase
CO680_06430	ENOG4105DFF	Rod shape-determining protein mreb
CO680_06435	ENOG4107EES	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity)
CO680_06440	ENOG410667J	hydrolase
CO680_06450	ENOG4105UIB	(ABC) transporter
CO680_06455	ENOG4108JQ9	ABC transporter
CO680_06460	ENOG4105DIH	basic membrane
CO680_06465	ENOG4105DIH	basic membrane
CO680_06470	ENOG4106F5Q	Membrane
CO680_06510	ENOG4108JQ1	Dehydrogenase
CO680_06515	ENOG4105DG4	malate L-lactate dehydrogenase
CO680_06530	ENOG4105CEY	Amp-dependent synthetase and ligase
CO680_06535	ENOG4105GVF	(ABC) transporter
CO680_06540	ENOG4105E2Y	ABC, transporter
CO680_06545	ENOG4105EFS	Binding-protein-dependent transport systems, inner membrane component
CO680_06570	ENOG4105CH7	arginosuccinase
CO680_06575	ENOG4105CDH	Citrulline--aspartate ligase
CO680_06585	ENOG4105C6Z	Gluconate
CO680_06590	ENOG4108Z0Z	intracellular protease Pfpi family
CO680_06595	ENOG4105KVH	Transcriptional regulator
CO680_06600	ENOG4105DKJ	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
CO680_06605	ENOG4105CAY	ferredoxin--nadp reductase
CO680_06630	ENOG4105DIH	basic membrane
CO680_06635	ENOG4105CTR	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity)
CO680_06640	ENOG4105WD1	Membrane
CO680_06645	ENOG410605W	Major Facilitator
CO680_06650	ENOG4105CDU	Replicative dna helicase
CO680_06655	ENOG4105K9Q	Binds to the 23S rRNA (By similarity)
CO680_06665	ENOG4108JQ7	(ABC) transporter
CO680_06675	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
CO680_06680	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
CO680_06685	ENOG4108J59	Extracellular solute-binding protein, family 5
CO680_06690	ENOG4105DRP	amino acid AbC transporter
CO680_06695	ENOG4105EAD	ABC transporter
CO680_06700	ENOG4105CT1	(ABC) transporter
CO680_06705	ENOG4105CDA	abc transporter atp-binding protein
CO680_06720	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
CO680_06730	ENOG4105DR1	Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity)
CO680_06735	ENOG4105D9R	oxidoreductase
CO680_06745	ENOG4105C31	Tryptophanyl-tRNA synthetase
CO680_06750	ENOG4105EEM	helicase
CO680_06755	ENOG4108YZM	Toxic component of a toxin-antitoxin (TA) module (By similarity)
CO680_06760	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
CO680_06765	ENOG4105C1J	atp-dependent rna helicase
CO680_06770	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
CO680_06775	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
CO680_06780	ENOG4108Z1Y	Participates in both the initiation and recycling phases of transcription. In the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling (By similarity)
CO680_06790	ENOG4105DCI	Phosphohydrolase
CO680_06800	ENOG4105C0H	protease
CO680_06805	ENOG4105Q2H	domain protein
CO680_06820	ENOG4105BZU	Histidine kinase
CO680_06825	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
CO680_06835	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
CO680_06840	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
CO680_06855	ENOG4105C12	Phosphoribosylglycinamide synthetase
CO680_06860	ENOG4105DC1	bifunctional purine biosynthesis protein purh
CO680_06865	ENOG4108V3E	phosphoribosylglycinamide formyltransferase
CO680_06870	ENOG4105CXB	phosphoribosylaminoimidazole synthetase
CO680_06880	ENOG4108JIU	phosphoribosylformylglycinamidine synthase ii
CO680_06885	ENOG4105D21	Phosphoribosylformylglycinamidine synthase I
CO680_06890	ENOG4105VR9	phosphoribosylformylglycinamidine synthase
CO680_06895	ENOG4105C8V	SAICAR synthetase
CO680_06905	ENOG4108UM6	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity)
CO680_06920	ENOG4108UUM	single-stranded DNA-binding protein
CO680_06925	ENOG4108ZDX	Binds together with S18 to 16S ribosomal RNA (By similarity)
CO680_06935	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
CO680_06945	ENOG4105DFT	pur operon repressor
CO680_06950	ENOG4108Z4K	mutator MutT protein
CO680_06960	ENOG4108HMR	Key enzyme in the regulation of glycerol uptake and metabolism (By similarity)
CO680_06965	ENOG410605W	Major Facilitator
CO680_06970	ENOG4107R2I	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation
CO680_06975	ENOG4105C5N	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
CO680_06980	ENOG4107QSE	Dipeptidase
CO680_06985	ENOG4107R7I	amino acid
CO680_06990	ENOG4105C7Q	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity)
CO680_07025	ENOG4105CG5	Glycosyl transferase (Group 1
CO680_07030	ENOG4105C8T	Leucyl-tRNA synthetase
CO680_07035	ENOG410841Q	phosphoesterase PA-phosphatase related protein
CO680_07045	ENOG4105EVU	fructokinase
CO680_07050	ENOG4108HKT	sucrose-6-phosphate hydrolase
CO680_07055	ENOG4105U0F	oligosaccharide H symporter, major facilitator superfamily (MFS)
CO680_07060	ENOG4105ETE	Transcriptional regulator (LacI family
CO680_07065	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
CO680_07075	ENOG4105DJ2	Major Facilitator Superfamily
CO680_07080	ENOG4108YYH	Nadph-dependent fmn reductase
CO680_07090	ENOG4108V06	Glutathione peroxidase
CO680_07095	ENOG4105BZ1	(ABC) transporter
CO680_07100	ENOG4105BZ1	(ABC) transporter
CO680_07105	ENOG4108TKW	Glyoxalase Bleomycin resistance protein (Dioxygenase
CO680_07135	ENOG4105C7K	acetolactate synthase
CO680_07175	ENOG4108IJ9	(ABC) transporter
CO680_07180	ENOG4105CNT	hydrolase family 2
CO680_07190	ENOG4105EG2	ABC transporter, permease
CO680_07225	ENOG4105VRR	gCN5-related N-acetyltransferase
CO680_07235	ENOG4105D8C	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity)
CO680_07240	ENOG4105CP7	Triose-phosphate isomerase
CO680_07245	ENOG4105C6V	Glycerol-3-phosphate dehydrogenase
CO680_07250	ENOG4108HMR	Key enzyme in the regulation of glycerol uptake and metabolism (By similarity)
CO680_07255	ENOG4108Z0Z	intracellular protease Pfpi family
CO680_07260	ENOG4108Z6X	(sortase) family
CO680_07270	ENOG4105DQ6	Transposase
CO680_07310	ENOG4107T8Q	Glycosyl transferase (Group 1
CO680_07325	ENOG4108IAJ	Nad-dependent epimerase dehydratase
CO680_07330	ENOG4107YJ4	chain length determinant protein
CO680_07340	ENOG4108RB3	Capsular polysaccharide biosynthesis protein
CO680_07345	ENOG4107QM2	Aldo Keto reductase
CO680_07350	ENOG4105C1B	dTDP-glucose 4-6-dehydratase
CO680_07355	ENOG4105DYT	3-hydroxyacyl-CoA dehydrogenase
CO680_07360	ENOG4105C28	cystathionine
CO680_07365	ENOG4105C56	H( )-stimulated, divalent metal cation uptake system (By similarity)
CO680_07420	ENOG4105CF3	3-Hydroxyisobutyrate dehydrogenase
CO680_07425	ENOG4108UPS	Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity)
CO680_07435	ENOG4105F27	Major Facilitator
CO680_07440	ENOG4105DC8	reductase
CO680_07465	ENOG4105D82	Glutamate dehydrogenase
CO680_07470	ENOG4108JQ7	(ABC) transporter
CO680_07485	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
CO680_07490	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
CO680_07515	ENOG4106KNT	transcriptional regulator
CO680_07525	ENOG4105DQ6	Transposase
CO680_07535	ENOG4107BMA	Transglycosylase associated protein
CO680_07565	ENOG4105CUU	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity)
CO680_07610	ENOG4105CRK	lysyL-tRNA synthetase
CO680_07615	ENOG4105F4C	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity)
CO680_07630	ENOG4105D3U	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity)
CO680_07640	ENOG41082I2	s4 domain protein
CO680_07650	ENOG4108JA2	transcriptioN-repair coupling factor
CO680_07655	ENOG4108ZPD	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity)
CO680_07665	ENOG4105DU1	integral membrane protein, terc
CO680_07670	ENOG4105ECB	domain protein
CO680_07695	ENOG4105C59	p-type ATPase
CO680_07700	ENOG4105C4B	ABC transporter, permease
CO680_07705	ENOG41083J0	(ABC) transporter
CO680_07715	ENOG4107VMU	Membrane
CO680_07730	ENOG4108UIN	ybak prolyl-trna synthetase associated region
CO680_07735	ENOG4105ETE	Transcriptional regulator (LacI family
CO680_07740	ENOG410667J	hydrolase
CO680_07745	ENOG4107TCE	N-acetyltransferase
CO680_07755	ENOG4105ECR	NmrA family
CO680_07765	ENOG4105C7K	acetolactate synthase
CO680_07775	ENOG4108JZF	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity)
CO680_07780	ENOG4105CM2	brancheD-chain amino acid aminotransferase
CO680_07830	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
CO680_07835	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
CO680_07840	ENOG4108JQ7	(ABC) transporter
CO680_07850	ENOG4108UZ3	Transporter
CO680_07860	ENOG4108ZQX	ybak prolyl-trna synthetase
CO680_07870	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
CO680_07875	ENOG4105EY8	ABC transporter
CO680_07885	ENOG4108R3E	Dna-3-methyladenine glycosylase i
CO680_07905	ENOG41067S9	phage shock protein C, PspC
CO680_07910	ENOG4108UQV	Membrane
CO680_07940	ENOG4107RNS	bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic
CO680_07955	ENOG4105D5T	phosphonate abc transporter
CO680_07965	ENOG4108KGH	TRANSCRIPTIONal
CO680_07970	ENOG4105C0V	Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity)
CO680_07975	ENOG4108UK2	deaminase
CO680_07985	ENOG4105C37	(CBS) domain
CO680_07990	ENOG4105C37	(CBS) domain
CO680_08000	ENOG4105HVR	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity)
CO680_08005	ENOG4105F8V	Hydrolase, tatD family
CO680_08010	ENOG4105EEQ	Na H antiporter
CO680_08015	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
CO680_08050	ENOG4105NDF	NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity)
CO680_08070	ENOG4105E0M	Sulfatase
CO680_08075	ENOG41082BV	acetyltransferase
CO680_08090	ENOG4105EYF	MMPL domain protein
CO680_08105	ENOG4108UMI	ABC transporter, permease
CO680_08110	ENOG4108JEI	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity)
CO680_08115	ENOG4105CHR	reductase
CO680_08120	ENOG4105DZW	Dipeptidase
CO680_08130	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
CO680_08135	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
CO680_08140	ENOG410848D	S4 domain protein YaaA
CO680_08145	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
CO680_08150	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
CO680_08155	ENOG4105VG0	50S ribosomal protein l34
CO680_08160	ENOG4105M7T	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)
CO680_08165	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
CO680_08170	ENOG4105C3F	Signal peptidase i
CO680_08180	ENOG4107XKZ	Amino acid ABC superfamily ATP binding cassette transporter binding protein
CO680_08185	ENOG4105E5Q	amino acid AbC transporter
CO680_08190	ENOG41082JN	Transcriptional regulator
CO680_08225	ENOG4105DS0	Transcriptional regulator, Crp Fnr family
CO680_08230	ENOG4105E0A	ABC, transporter
CO680_08250	ENOG4106ST0	Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity)
CO680_08255	ENOG4107ZYR	domain protein
CO680_08260	ENOG4105C85	amino acid
CO680_08270	ENOG4105DQ6	Transposase
CO680_08295	ENOG4105CA8	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity)
CO680_08300	ENOG4105CE7	Amidase, hydantoinase carbamoylase family
CO680_08305	ENOG4105CK2	sodium dicarboxylate symporter
CO680_08310	ENOG4105EAB	amino acid AbC transporter
CO680_08315	ENOG4105CDA	abc transporter atp-binding protein
CO680_08320	ENOG4105DRP	amino acid AbC transporter
CO680_08325	ENOG4105C28	cystathionine
CO680_08330	ENOG4105C28	cystathionine
CO680_08335	ENOG4105D6E	homoserine dehydrogenase
CO680_08340	ENOG4105CR8	Transcriptional regulator
CO680_08345	ENOG4105JAB	phenazine biosynthesis protein, phzf family
CO680_08370	ENOG4105DZR	Type I site-specific deoxyribonuclease
CO680_08400	ENOG4105TMB	Formate nitrite transporter
CO680_08410	ENOG4108UXA	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity)
CO680_08420	ENOG4108HCJ	Hydrolase
CO680_08425	ENOG4108UMW	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
CO680_08430	ENOG4105CZE	histidine utilization repressor
CO680_08435	ENOG4105CZV	ABC transporter
CO680_08450	ENOG4105CVG	Homoserine O-transsuccinylase
CO680_08460	ENOG4105C7N	Xanthine uracil vitamin C permease
CO680_08470	ENOG4105C5I	Dehydrogenase
CO680_08475	ENOG4105CHM	Aminotransferase
CO680_08505	ENOG4105BZA	Phosphoglycerate kinase
CO680_08515	ENOG4107QTZ	amino acid
CO680_08520	ENOG4105F4P	)-transporter
CO680_08525	ENOG4108UW5	maltose o-acetyltransferase
CO680_08530	ENOG4108UW5	maltose o-acetyltransferase
CO680_08535	ENOG4105CHM	Aminotransferase
CO680_08545	ENOG4105KIS	phospholipid-binding protein
CO680_08555	ENOG4105FR1	rard protein
CO680_08560	ENOG4105C5I	Dehydrogenase
CO680_08570	ENOG4105FKQ	transcriptional regulator
CO680_08590	ENOG4105CV8	reductase
CO680_08595	ENOG4108JZF	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity)
CO680_08605	ENOG4107YB6	acetyltransferase, (GNAT) family
CO680_08630	ENOG4105HJX	Biotin- acetyl-CoA-carboxylase ligase
CO680_08635	ENOG41080Y5	BioY family
CO680_08640	ENOG4107QUY	Guanine deaminase
CO680_08665	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
CO680_08690	ENOG41079KZ	Major Facilitator Superfamily
CO680_08695	ENOG4107TXC	Transcriptional regulator
CO680_08700	ENOG4105CYX	Short-chain dehydrogenase reductase Sdr
CO680_08710	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
CO680_08715	ENOG4105GR3	Histidine kinase
CO680_08720	ENOG4105DQR	SNARE associated Golgi
CO680_08740	ENOG41082BM	Transcriptional regulator, arsr family
CO680_08745	ENOG4105CUK	Alpha-N-arabinofuranosidase (EC 3.2.1.55)
CO680_08755	ENOG4105BZC	d-serine deaminase
CO680_08760	ENOG4105CGT	Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity)
CO680_08765	ENOG4105C2S	Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity)
CO680_08790	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
CO680_08805	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
CO680_08810	ENOG4108V7D	UPF0397 protein
CO680_08815	ENOG4108JJB	ABC transporter
CO680_08825	ENOG4105CQB	FAD linked oxidase domain protein
CO680_08830	ENOG4105CHM	Aminotransferase
CO680_08855	ENOG4105CHR	reductase
CO680_08875	ENOG4105CDA	abc transporter atp-binding protein
CO680_08880	ENOG4105E5Q	amino acid AbC transporter
CO680_08885	ENOG4105EAB	amino acid AbC transporter
CO680_08890	ENOG410855V	Acylphosphatase
CO680_08915	ENOG4105C85	amino acid
CO680_08935	ENOG4105CHR	reductase
CO680_08945	ENOG4105C26	Dehydrogenase
CO680_08955	ENOG4105HMI	Membrane
CO680_08965	ENOG4105DUM	transcriptional regulator, lysR family
CO680_08980	ENOG4105CUB	amino acid
CO680_08990	ENOG4105CQ3	Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity)
CO680_08995	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
CO680_09005	ENOG4107U9W	Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S- specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX (By similarity)
CO680_09015	ENOG4105D8C	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity)
CO680_09025	ENOG4105CIG	ABC transporter
CO680_09030	ENOG4108RZE	Tetr family transcriptional regulator
CO680_09035	ENOG4108W5N	phosphatidylglycerophosphatase a
CO680_09040	ENOG4105EE6	Alcohol dehydrogenase zinc-binding domain protein
CO680_09050	ENOG4107R7I	amino acid
CO680_09070	ENOG4105CJD	(Anaerobic) ribonucleoside-triphosphate reductase
CO680_09075	ENOG4108RDD	Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity)
CO680_09080	ENOG4105C3K	feS assembly ATPase SufC
CO680_09085	ENOG4105JRK	feS assembly protein SufD
CO680_09090	ENOG4105C9B	Cysteine desulfurase
CO680_09095	ENOG4107YH3	SUF system FeS assembly protein, NifU family
CO680_09100	ENOG4105DIW	FeS assembly protein SUFB
CO680_09110	ENOG4105CUB	amino acid
CO680_09115	ENOG4105HDK	L-asparaginase
CO680_09120	ENOG4105VEM	Conserved domain protein
CO680_09130	ENOG4108TZA	Required for optimal enterobactin synthesis. Acts as a proofreading enzyme that prevents EntB misacylation by hydrolyzing the thioester bound existing between EntB and wrongly charged molecules (By similarity)
CO680_09135	ENOG4108IPT	Naphthoate synthase
CO680_09140	ENOG4105CEY	Amp-dependent synthetase and ligase
CO680_09145	ENOG4105DQ6	Transposase
CO680_09165	ENOG4107QTZ	amino acid
CO680_09170	ENOG4108STX	response regulator
CO680_09175	ENOG4105US7	Histidine kinase
CO680_09180	ENOG4105E66	phosphoriboisomerase A
CO680_09185	ENOG4105CEN	a g-specific adenine glycosylase
CO680_09195	ENOG4107QJE	Chromosome Partitioning Protein
CO680_09200	ENOG4105FA0	parb-like partition protein
CO680_09210	ENOG4105C3G	gtp-binding protein
CO680_09220	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
CO680_09255	ENOG4105DUX	Transporter
CO680_09280	ENOG410906U	SprT-like
CO680_09285	ENOG4105EXC	Acyl-transferase
CO680_09300	ENOG4105FDK	ABC transporter
CO680_09310	ENOG4105C5H	ABC transporter
CO680_09315	ENOG4107QNK	)-transporter
CO680_09340	ENOG4105CAC	Catalyzes the conversion of L-arabinose to L-ribulose (By similarity)
CO680_09360	ENOG4105CDA	abc transporter atp-binding protein
CO680_09365	ENOG4105EAD	ABC transporter
CO680_09375	ENOG4105EAD	ABC transporter
CO680_09395	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
CO680_09400	ENOG4108TZY	GntR Family Transcriptional Regulator
CO680_09405	ENOG4107QRI	Phosphoketolase
CO680_09415	ENOG4105C9K	Endothelin-converting enzyme 1
CO680_09420	ENOG4105NA0	Transcriptional regulator
CO680_09435	ENOG4105C59	p-type ATPase
CO680_09440	ENOG4108EKI	Dehydrogenase
CO680_09445	ENOG4105CGK	Exodeoxyribonuclease III
CO680_09460	ENOG4105DKJ	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
CO680_09465	ENOG4105C1N	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity)
CO680_09470	ENOG4105BZ1	(ABC) transporter
CO680_09475	ENOG4105BZ1	(ABC) transporter
CO680_09480	ENOG4107EXU	Short-chain dehydrogenase reductase Sdr
CO680_09500	ENOG4105DMS	mur ligase
CO680_09505	ENOG4105F1K	Glutamine amidotransferase
CO680_09510	ENOG4107104	thymidine kinase
CO680_09520	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
CO680_09525	ENOG4105EK0	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
CO680_09530	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
CO680_09555	ENOG4105WS6	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
CO680_09560	ENOG4107ZFM	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity)
CO680_09565	ENOG4107YZM	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
CO680_09570	ENOG4105CDG	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity)
CO680_09575	ENOG4105J80	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity)
CO680_09580	ENOG4105C4J	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
CO680_09585	ENOG4105KNM	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
CO680_09590	ENOG4105ZMH	deoxynucleoside kinase
CO680_09595	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
CO680_09620	ENOG4105KEX	transcriptional regulator, ctsr
CO680_09625	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit