locus-tag	class	description
CO680_00005	COG0085	RNA polymerase activity
CO680_00015	COG1979	alcohol dehydrogenase
CO680_00020	COG0500	methyltransferase
CO680_00040	COG1983	PspC domain protein
CO680_00050	COG2814	Major facilitator Superfamily
CO680_00060	COG0488	(ABC) transporter
CO680_00070	COG2813	Specifically methylates the guanine in position
CO680_00085	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CO680_00090	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CO680_00095	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CO680_00105	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CO680_00110	COG3870	Protein conserved in bacteria
CO680_00130	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CO680_00135	COG1214	PFAM Peptidase M22, glycoprotease
CO680_00150	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CO680_00155	COG0142	geranyltranstransferase activity
CO680_00160	COG0051	transcription antitermination factor activity, RNA binding
CO680_00165	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CO680_00175	COG0089	rRNA binding
CO680_00180	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CO680_00185	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CO680_00190	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CO680_00195	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CO680_00200	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CO680_00205	COG0255	Belongs to the universal ribosomal protein uL29 family
CO680_00215	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CO680_00220	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CO680_00225	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CO680_00230	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CO680_00235	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CO680_00240	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CO680_00245	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CO680_00255	COG0200	Binds to the 23S rRNA
CO680_00270	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CO680_00275	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CO680_00280	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CO680_00285	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CO680_00290	COG0202	RNA polymerase activity
CO680_00295	COG0203	ribosomal protein L17
CO680_00305	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CO680_00320	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CO680_00325	COG1464	Belongs to the NlpA lipoprotein family
CO680_00335	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CO680_00350	COG2801	Transposase and inactivated derivatives
CO680_00355	COG0667	Aldo Keto reductase
CO680_00360	COG0215	cysteine-tRNA ligase activity
CO680_00365	COG1854	S-ribosylhomocysteine lyase activity
CO680_00370	COG2877	3-deoxy-8-phosphooctulonate synthase activity
CO680_00375	COG0517	IMP dehydrogenase activity
CO680_00375	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
CO680_00380	COG0540	Belongs to the ATCase OTCase family
CO680_00390	COG0505	Belongs to the CarA family
CO680_00395	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CO680_00400	COG0167	dihydroorotate dehydrogenase activity
CO680_00405	COG0284	orotidine-5'-phosphate decarboxylase activity
CO680_00410	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CO680_00415	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
CO680_00420	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CO680_00430	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CO680_00440	COG0250	Participates in transcription elongation, termination and antitermination
CO680_00445	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CO680_00450	COG0081	regulation of translation
CO680_00455	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CO680_00460	COG0222	ribosome binding
CO680_00470	COG1121	(ABC) transporter
CO680_00475	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CO680_00480	COG0803	Belongs to the bacterial solute-binding protein 9 family
CO680_00485	COG1252	NADH dehydrogenase
CO680_00495	COG1122	ATPase activity
CO680_00500	COG1122	ATPase activity
CO680_00505	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
CO680_00510	COG0101	tRNA pseudouridine synthase activity
CO680_00515	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CO680_00520	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CO680_00555	COG2169	Transcriptional regulator
CO680_00555	COG1917	Cupin 2, conserved barrel domain protein
CO680_00575	COG0477	Major facilitator Superfamily
CO680_00585	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
CO680_00595	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CO680_00610	COG2390	Transcriptional regulator
CO680_00615	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CO680_00615	COG0574	Belongs to the PEP-utilizing enzyme family
CO680_00640	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CO680_00660	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CO680_00665	COG0667	Aldo Keto reductase
CO680_00675	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CO680_00685	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CO680_00685	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
CO680_00690	COG3715	PTS system
CO680_00710	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CO680_00710	COG3711	transcriptional antiterminator
CO680_00725	COG3775	system Galactitol-specific IIC component
CO680_00740	COG1573	uracil-dna glycosylase
CO680_00765	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CO680_00775	COG1660	Displays ATPase and GTPase activities
CO680_00780	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CO680_00785	COG1481	regulation of sporulation
CO680_00790	COG0740	serine-type endopeptidase activity
CO680_00825	COG0028	Belongs to the TPP enzyme family
CO680_00830	COG3527	Alpha-acetolactate decarboxylase
CO680_00835	COG0604	alcohol dehydrogenase
CO680_00840	COG0542	response to heat
CO680_00845	COG3942	CHAP domain
CO680_00860	COG0756	dUTP diphosphatase activity
CO680_00870	COG4956	integral membrane protein (PIN domain superfamily)
CO680_00885	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
CO680_00895	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CO680_00905	COG2814	Major facilitator Superfamily
CO680_00910	COG1733	regulation of RNA biosynthetic process
CO680_00915	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CO680_00920	COG0072	phenylalanine-tRNA ligase activity
CO680_00920	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CO680_00925	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CO680_00930	COG0514	ATP-dependent DNA helicase (RecQ)
CO680_00935	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CO680_00945	COG0768	penicillin binding
CO680_00950	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CO680_00965	COG1940	carbohydrate kinase activity
CO680_00970	COG3942	CHAP domain
CO680_00970	COG1388	LysM domain
CO680_00975	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CO680_00985	COG0584	glycerophosphoryl diester phosphodiesterase
CO680_00990	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CO680_00995	COG0789	Transcriptional regulator
CO680_01000	COG0174	glutamine synthetase
CO680_01025	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CO680_01030	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CO680_01040	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
CO680_01115	COG0577	efflux transmembrane transporter activity
CO680_01120	COG1136	(ABC) transporter
CO680_01120	COG0577	efflux transmembrane transporter activity
CO680_01135	COG1169	isochorismate synthase
CO680_01140	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
CO680_01150	COG4948	Mandelate Racemase Muconate Lactonizing
CO680_01155	COG0006	proline dipeptidase activity
CO680_01170	COG0737	Belongs to the 5'-nucleotidase family
CO680_01175	COG4470	Protein conserved in bacteria
CO680_01180	COG0647	UMP catabolic process
CO680_01190	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CO680_01195	COG0573	inorganic phosphate transmembrane transporter activity
CO680_01200	COG0581	inorganic phosphate transmembrane transporter activity
CO680_01210	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CO680_01220	COG2137	regulation of response to DNA damage stimulus
CO680_01230	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CO680_01240	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CO680_01250	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CO680_01260	COG0589	response to stress
CO680_01275	COG1272	protein, Hemolysin III
CO680_01285	COG0525	valine-tRNA ligase activity
CO680_01290	COG0285	dihydrofolate synthase activity
CO680_01295	COG0488	(ABC) transporter
CO680_01300	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CO680_01305	COG0459	protein refolding
CO680_01310	COG0531	amino acid
CO680_01320	COG1181	Belongs to the D-alanine--D-alanine ligase family
CO680_01325	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
CO680_01330	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
CO680_01340	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CO680_01345	COG1713	HD superfamily hydrolase involved in NAD metabolism
CO680_01350	COG0799	negative regulation of ribosome biogenesis
CO680_01360	COG1323	Belongs to the UPF0348 family
CO680_01370	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CO680_01375	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CO680_01385	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CO680_01390	COG0363	glucosamine-6-phosphate deaminase activity
CO680_01400	COG4720	Psort location CytoplasmicMembrane, score
CO680_01405	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CO680_01410	COG1570	exodeoxyribonuclease VII activity
CO680_01415	COG1722	exodeoxyribonuclease VII activity
CO680_01425	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
CO680_01430	COG1438	arginine binding
CO680_01435	COG0497	DNA recombination
CO680_01440	COG0194	GDP metabolic process
CO680_01450	COG0586	Pfam SNARE associated Golgi protein
CO680_01460	COG1185	polyribonucleotide nucleotidyltransferase activity
CO680_01570	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CO680_01575	COG1271	oxidase subunit
CO680_01580	COG1294	oxidase, subunit
CO680_01585	COG4988	ABC transporter
CO680_01590	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
CO680_01595	COG1705	Flagellar rod assembly protein muramidase FlgJ
CO680_01615	COG1278	Cold shock
CO680_01620	COG0494	nUDIX hydrolase
CO680_01630	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CO680_01640	COG1388	LysM domain
CO680_01660	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CO680_01665	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CO680_01680	COG4120	Belongs to the binding-protein-dependent transport system permease family
CO680_01685	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CO680_01690	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CO680_01695	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CO680_01710	COG2003	Belongs to the UPF0758 family
CO680_01715	COG1077	Cell shape determining protein MreB Mrl
CO680_01720	COG1792	Involved in formation and maintenance of cell shape
CO680_01735	COG0765	amino acid transport
CO680_01740	COG1126	abc transporter atp-binding protein
CO680_01750	COG2759	Belongs to the formate--tetrahydrofolate ligase family
CO680_01760	COG0833	amino acid
CO680_01770	COG2264	protein methyltransferase activity
CO680_01775	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CO680_01785	COG2001	Belongs to the MraZ family
CO680_01790	COG0275	rRNA processing
CO680_01805	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CO680_01810	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CO680_01815	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CO680_01820	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CO680_01825	COG0849	cell division
CO680_01835	COG1799	cell septum assembly
CO680_01840	COG0762	integral membrane protein
CO680_01850	COG3599	regulation of cell shape
CO680_01855	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CO680_01860	COG0588	phosphoglycerate mutase activity
CO680_01870	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CO680_01875	COG0217	transcriptional regulatory protein
CO680_01880	COG2252	PERMEase
CO680_01915	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CO680_01920	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CO680_01925	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CO680_01930	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CO680_01930	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CO680_01935	COG0631	protein serine/threonine phosphatase activity
CO680_01940	COG2815	serine threonine protein kinase
CO680_01940	COG0515	serine threonine protein kinase
CO680_01945	COG1162	GTPase activity
CO680_01950	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CO680_01955	COG1564	THIamine pyrophosphokinase
CO680_01960	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CO680_01970	COG1461	Dihydroxyacetone kinase
CO680_01975	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CO680_01980	COG0416	fatty acid biosynthetic process
CO680_01985	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CO680_01990	COG0571	ribonuclease III activity
CO680_01995	COG1196	nuclear chromosome segregation
CO680_02000	COG0552	protein localization to endoplasmic reticulum
CO680_02010	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CO680_02015	COG0228	four-way junction DNA binding
CO680_02025	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CO680_02030	COG0336	Belongs to the RNA methyltransferase TrmD family
CO680_02045	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CO680_02050	COG1942	4-Oxalocrotonate Tautomerase
CO680_02060	COG0791	NLP P60 protein
CO680_02065	COG1428	Deoxynucleoside kinase
CO680_02070	COG1970	mechanosensitive ion channel activity
CO680_02075	COG0561	phosphatase activity
CO680_02100	COG0582	viral genome integration into host DNA
CO680_02120	COG1396	sequence-specific DNA binding
CO680_02130	COG3646	Phage regulatory protein
CO680_02175	COG1396	sequence-specific DNA binding
CO680_02195	COG0629	single-stranded DNA binding
CO680_02235	COG1956	GAF domain-containing protein
CO680_02250	COG2261	transglycosylase associated protein
CO680_02270	COG5484	DNA packaging
CO680_02270	COG3728	DNA packaging
CO680_02275	COG1783	phage Terminase large subunit
CO680_02380	COG3223	Belongs to the PsiE family
CO680_02390	COG3853	Toxic anion resistance protein (TelA)
CO680_02395	COG1393	Belongs to the ArsC family
CO680_02400	COG4862	establishment of competence for transformation
CO680_02410	COG1164	Oligoendopeptidase f
CO680_02425	COG0006	proline dipeptidase activity
CO680_02430	COG1609	Transcriptional regulator
CO680_02435	COG0531	amino acid
CO680_02445	COG3527	Alpha-acetolactate decarboxylase
CO680_02465	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CO680_02470	COG3425	synthase
CO680_02480	COG0860	N-Acetylmuramoyl-L-alanine amidase
CO680_02485	COG0124	histidyl-tRNA synthetase
CO680_02490	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CO680_02495	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CO680_02500	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CO680_02505	COG1610	YqeY-like protein
CO680_02510	COG1702	phosphate starvation-inducible protein PhoH
CO680_02515	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CO680_02520	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
CO680_02525	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CO680_02530	COG1381	Involved in DNA repair and RecF pathway recombination
CO680_02535	COG0752	glycyl-tRNA synthetase alpha subunit
CO680_02540	COG0751	glycine-tRNA ligase activity
CO680_02550	COG2706	6-phosphogluconolactonase activity
CO680_02555	COG0628	permease
CO680_02565	COG1674	ftsk spoiiie
CO680_02570	COG4152	abc transporter atp-binding protein
CO680_02575	COG1668	transmembrane transport
CO680_02580	COG0322	excinuclease ABC activity
CO680_02585	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CO680_02590	COG1739	Uncharacterized protein family UPF0029
CO680_02605	COG0632	four-way junction helicase activity
CO680_02610	COG2255	four-way junction helicase activity
CO680_02615	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CO680_02650	COG0343	queuine tRNA-ribosyltransferase activity
CO680_02660	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CO680_02665	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
CO680_02670	COG0513	Belongs to the DEAD box helicase family
CO680_02675	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CO680_02680	COG4472	Bacterial protein of unknown function (DUF965)
CO680_02695	COG3906	Belongs to the UPF0473 family
CO680_02705	COG0658	competence protein
CO680_02705	COG2333	competence protein COMEC
CO680_02710	COG1466	dna polymerase III delta subunit
CO680_02715	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CO680_02720	COG0268	Binds directly to 16S ribosomal RNA
CO680_02740	COG0544	peptidyl-prolyl cis-trans isomerase activity
CO680_02745	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CO680_02750	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CO680_02760	COG1286	toxin biosynthetic process
CO680_02765	COG1193	negative regulation of DNA recombination
CO680_02770	COG3118	belongs to the thioredoxin family
CO680_02825	COG0546	phosphoglycolate phosphatase activity
CO680_02835	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CO680_02850	COG2357	RelA SpoT domain protein
CO680_02855	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CO680_02860	COG0564	pseudouridine synthase activity
CO680_02865	COG2239	Acts as a magnesium transporter
CO680_02870	COG0779	Required for maturation of 30S ribosomal subunits
CO680_02875	COG0195	Participates in both transcription termination and antitermination
CO680_02880	COG2740	Nucleic-acid-binding protein implicated in transcription termination
CO680_02890	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CO680_02895	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CO680_02900	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CO680_02905	COG0196	riboflavin kinase activity
CO680_02915	COG3142	Participates in the control of copper homeostasis
CO680_02925	COG1307	EDD domain protein, DegV family
CO680_02930	COG1307	EDD domain protein, DegV family
CO680_02935	COG2755	lipolytic protein G-D-S-L family
CO680_02945	COG4479	Belongs to the UPF0346 family
CO680_02960	COG0758	DNA mediated transformation
CO680_02965	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CO680_02970	COG4974	Belongs to the 'phage' integrase family
CO680_02985	COG0187	DNA topoisomerase II activity
CO680_02995	COG1227	inorganic diphosphatase activity
CO680_03005	COG4175	Glycine betaine
CO680_03005	COG3448	diguanylate cyclase activity
CO680_03020	COG0446	pyridine nucleotide-disulphide oxidoreductase
CO680_03025	COG1464	Belongs to the NlpA lipoprotein family
CO680_03030	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CO680_03035	COG1597	lipid kinase activity
CO680_03055	COG0242	peptide deformylase activity
CO680_03065	COG0483	inositol monophosphate 1-phosphatase activity
CO680_03075	COG0772	Belongs to the SEDS family
CO680_03080	COG4471	UPF0298 protein
CO680_03085	COG0742	ribosomal rna small subunit methyltransferase
CO680_03090	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CO680_03095	COG3480	Lon protease (S16) C-terminal proteolytic domain
CO680_03100	COG0095	Lipoate-protein ligase
CO680_03115	COG0508	dehydrogenase complex catalyzes the overall conversion of
CO680_03125	COG2267	carboxylic ester hydrolase activity
CO680_03130	COG4166	transmembrane transport
CO680_03135	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CO680_03140	COG0024	Methionine aminopeptidase
CO680_03145	COG2190	(PTS) system
CO680_03145	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CO680_03145	COG1263	PTS System
CO680_03160	COG2188	Transcriptional regulator
CO680_03170	COG2190	(PTS) system
CO680_03170	COG1263	PTS System
CO680_03170	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CO680_03175	COG1554	hydrolase, family 65, central catalytic
CO680_03180	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CO680_03185	COG0531	amino acid
CO680_03195	COG1053	succinate dehydrogenase
CO680_03225	COG1619	proteins homologs of microcin C7 resistance protein MccF
CO680_03235	COG2801	Transposase and inactivated derivatives
CO680_03260	COG0358	DNA primase activity
CO680_03265	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CO680_03280	COG0745	RESPONSE REGULATOR receiver
CO680_03285	COG5002	protein histidine kinase activity
CO680_03290	COG0572	uridine kinase
CO680_03295	COG1363	Peptidase, m42
CO680_03300	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CO680_03310	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CO680_03315	COG0670	Belongs to the BI1 family
CO680_03320	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CO680_03320	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CO680_03345	COG2261	transglycosylase associated protein
CO680_03375	COG0577	efflux transmembrane transporter activity
CO680_03385	COG1846	Transcriptional regulator
CO680_03390	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CO680_03395	COG0604	alcohol dehydrogenase
CO680_03400	COG3759	membrane
CO680_03405	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CO680_03410	COG0237	dephospho-CoA kinase activity
CO680_03420	COG1484	DNA-dependent DNA replication
CO680_03435	COG0745	RESPONSE REGULATOR receiver
CO680_03440	COG5002	protein histidine kinase activity
CO680_03450	COG0706	membrane insertase activity
CO680_03460	COG1304	FMN binding
CO680_03475	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
CO680_03480	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CO680_03480	COG1199	ATP-dependent helicase activity
CO680_03490	COG0017	Asparaginyl-tRNA synthetase
CO680_03520	COG3935	DnaD domain protein
CO680_03525	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CO680_03530	COG3331	DNA recombination
CO680_03535	COG4474	Belongs to the UPF0398 family
CO680_03550	COG0116	Belongs to the methyltransferase superfamily
CO680_03560	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CO680_03575	COG0556	nucleotide-excision repair
CO680_03590	COG0537	adenosine 5'-monophosphoramidase activity
CO680_03595	COG1131	(ABC) transporter
CO680_03605	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CO680_03630	COG0351	phosphomethylpyrimidine kinase
CO680_03645	COG2223	nitrite transmembrane transporter activity
CO680_03655	COG0366	Alpha amylase catalytic
CO680_03675	COG2801	Transposase and inactivated derivatives
CO680_03690	COG3409	Peptidoglycan-binding domain 1 protein
CO680_03700	COG3409	Peptidoglycan-binding domain 1 protein
CO680_03715	COG1396	sequence-specific DNA binding
CO680_03795	COG2801	Transposase and inactivated derivatives
CO680_03830	COG2814	Major facilitator Superfamily
CO680_03840	COG5039	Polysaccharide pyruvyl transferase
CO680_03845	COG2261	transglycosylase associated protein
CO680_03880	COG2217	Heavy metal translocating P-type atpase
CO680_03900	COG0656	L-ascorbic acid biosynthetic process
CO680_03905	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CO680_03910	COG2017	converts alpha-aldose to the beta-anomer
CO680_03960	COG0583	DNA-binding transcription factor activity
CO680_03965	COG0281	malic enzyme
CO680_04000	COG2816	NAD+ diphosphatase activity
CO680_04005	COG1012	belongs to the aldehyde dehydrogenase family
CO680_04035	COG2246	polysaccharide biosynthetic process
CO680_04040	COG1942	4-Oxalocrotonate Tautomerase
CO680_04045	COG3022	response to hydroperoxide
CO680_04055	COG1464	Belongs to the NlpA lipoprotein family
CO680_04070	COG0588	phosphoglycerate mutase activity
CO680_04075	COG2814	Major facilitator Superfamily
CO680_04095	COG0071	Belongs to the small heat shock protein (HSP20) family
CO680_04105	COG2755	lipolytic protein G-D-S-L family
CO680_04105	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
CO680_04115	COG0277	FAD linked oxidase domain protein
CO680_04120	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CO680_04155	COG0481	GTPase activity
CO680_04160	COG4708	membrane
CO680_04175	COG4166	transmembrane transport
CO680_04180	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CO680_04190	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
CO680_04200	COG2211	Major facilitator Superfamily
CO680_04200	COG2190	(PTS) system
CO680_04205	COG4977	sequence-specific DNA binding
CO680_04205	COG1917	Cupin 2, conserved barrel domain protein
CO680_04225	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CO680_04230	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CO680_04240	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
CO680_04255	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CO680_04260	COG2384	SAM-dependent methyltransferase
CO680_04265	COG0457	Tetratricopeptide repeat
CO680_04280	COG0419	ATPase involved in DNA repair
CO680_04285	COG0420	3'-5' exonuclease activity
CO680_04290	COG4720	Psort location CytoplasmicMembrane, score
CO680_04295	COG0351	phosphomethylpyrimidine kinase
CO680_04300	COG0776	regulation of translation
CO680_04305	COG1160	GTP binding
CO680_04310	COG0539	negative regulation of cytoplasmic translation
CO680_04315	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CO680_04320	COG2801	Transposase and inactivated derivatives
CO680_04335	COG0514	ATP-dependent DNA helicase (RecQ)
CO680_04345	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
CO680_04350	COG1187	pseudouridine synthase activity
CO680_04355	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CO680_04360	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
CO680_04375	COG2996	Protein conserved in bacteria
CO680_04385	COG0475	glutathione-regulated potassium exporter activity
CO680_04395	COG1490	D-aminoacyl-tRNA deacylase activity
CO680_04400	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CO680_04405	COG0587	DNA-directed DNA polymerase activity
CO680_04420	COG0488	(ABC) transporter
CO680_04425	COG0617	tRNA 3'-terminal CCA addition
CO680_04435	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CO680_04440	COG0004	ammonium transporteR
CO680_04445	COG1316	TRANSCRIPTIONal
CO680_04460	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CO680_04465	COG2801	Transposase and inactivated derivatives
CO680_04475	COG0052	Belongs to the universal ribosomal protein uS2 family
CO680_04480	COG2827	Endonuclease containing a URI domain
CO680_04485	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
CO680_04490	COG0204	Acyl-transferase
CO680_04495	COG3763	UPF0154 protein
CO680_04500	COG4224	UPF0291 protein
CO680_04505	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CO680_04510	COG1285	pathogenesis
CO680_04515	COG0110	maltose O-acetyltransferase activity
CO680_04540	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
CO680_04540	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CO680_04545	COG1234	tRNA 3'-trailer cleavage
CO680_04560	COG0484	heat shock protein binding
CO680_04565	COG0443	Heat shock 70 kDa protein
CO680_04570	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CO680_04575	COG1420	regulation of RNA biosynthetic process
CO680_04595	COG5617	Psort location CytoplasmicMembrane, score
CO680_04600	COG1216	Glycosyl transferase, family 2
CO680_04605	COG0463	Glycosyl transferase, family 2
CO680_04625	COG0562	UDP-galactopyranose mutase
CO680_04650	COG0024	Methionine aminopeptidase
CO680_04700	COG2723	6-phospho-beta-galactosidase activity
CO680_04705	COG2188	Transcriptional regulator
CO680_04710	COG0561	phosphatase activity
CO680_04745	COG0438	transferase activity, transferring glycosyl groups
CO680_04760	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CO680_04765	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
CO680_04765	COG0463	Glycosyl transferase, family 2
CO680_04780	COG1682	transport, permease protein
CO680_04785	COG1134	teichoic acid transport
CO680_04785	COG1388	LysM domain
CO680_04795	COG3475	LICD family
CO680_04800	COG0393	Putative heavy-metal-binding
CO680_04825	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CO680_04830	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CO680_04840	COG2309	aminopeptidase activity
CO680_04850	COG0564	pseudouridine synthase activity
CO680_04855	COG1278	Cold shock
CO680_04865	COG2814	Major facilitator Superfamily
CO680_04870	COG0741	lytic transglycosylase activity
CO680_04880	COG3973	AAA domain
CO680_04885	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CO680_04890	COG1058	Belongs to the CinA family
CO680_04890	COG1546	Belongs to the CinA family
CO680_04895	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CO680_04900	COG1426	Protein conserved in bacteria
CO680_04905	COG0612	Peptidase, M16
CO680_04925	COG1704	LemA family
CO680_04935	COG3402	PFAM membrane-flanked domain
CO680_04950	COG4717	serine-type aminopeptidase activity
CO680_04955	COG0420	3'-5' exonuclease activity
CO680_04960	COG3679	Belongs to the UPF0342 family
CO680_04965	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CO680_04970	COG1438	arginine binding
CO680_04975	COG0018	arginyl-trna synthetase
CO680_04995	COG0285	dihydrofolate synthase activity
CO680_05000	COG1597	lipid kinase activity
CO680_05005	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CO680_05010	COG0154	amidase activity
CO680_05015	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CO680_05020	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
CO680_05020	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CO680_05030	COG2936	dipeptidyl-peptidase activity
CO680_05050	COG1914	H( )-stimulated, divalent metal cation uptake system
CO680_05065	COG0667	Aldo Keto reductase
CO680_05070	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CO680_05075	COG4721	ABC-type cobalt transport system, permease component
CO680_05080	COG1122	ATPase activity
CO680_05090	COG0402	S-adenosylhomocysteine deaminase activity
CO680_05095	COG4166	transmembrane transport
CO680_05105	COG0710	3-dehydroquinate dehydratase activity
CO680_05110	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CO680_05115	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CO680_05120	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CO680_05125	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CO680_05130	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
CO680_05135	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CO680_05140	COG4684	Psort location CytoplasmicMembrane, score
CO680_05145	COG0436	Aminotransferase
CO680_05160	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CO680_05165	COG0436	Aminotransferase
CO680_05175	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CO680_05180	COG1473	amidohydrolase
CO680_05185	COG2171	N-acyltransferase activity
CO680_05190	COG0019	diaminopimelate decarboxylase activity
CO680_05195	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CO680_05200	COG0527	aspartate kinase activity
CO680_05210	COG1609	Transcriptional regulator
CO680_05225	COG1321	iron dependent repressor
CO680_05225	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CO680_05230	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
CO680_05235	COG0513	Belongs to the DEAD box helicase family
CO680_05240	COG0673	inositol 2-dehydrogenase activity
CO680_05245	COG1335	isochorismatase
CO680_05250	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CO680_05255	COG0501	Belongs to the peptidase M48B family
CO680_05260	COG1704	LemA family
CO680_05265	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CO680_05280	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CO680_05285	COG0439	Biotin carboxylase
CO680_05300	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CO680_05305	COG1028	Short-chain dehydrogenase reductase Sdr
CO680_05315	COG2070	2-Nitropropane dioxygenase
CO680_05320	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CO680_05325	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CO680_05335	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CO680_05345	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CO680_05350	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CO680_05360	COG0505	Belongs to the CarA family
CO680_05365	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
CO680_05370	COG0564	pseudouridine synthase activity
CO680_05380	COG0328	RNA-DNA hybrid ribonuclease activity
CO680_05405	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CO680_05410	COG1174	glycine betaine transport
CO680_05425	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
CO680_05435	COG0583	DNA-binding transcription factor activity
CO680_05440	COG0126	phosphoglycerate kinase activity
CO680_05525	COG0604	alcohol dehydrogenase
CO680_05560	COG1295	ribonuclease BN
CO680_05585	COG2801	Transposase and inactivated derivatives
CO680_05620	COG1028	Short-chain dehydrogenase reductase Sdr
CO680_05650	COG1250	3-hydroxyacyl-CoA dehydrogenase
CO680_05670	COG0456	acetyltransferase
CO680_05685	COG0582	viral genome integration into host DNA
CO680_05720	COG3716	PTS system mannose fructose sorbose family IID component
CO680_05725	COG3715	PTS system
CO680_05790	COG1368	sulfuric ester hydrolase activity
CO680_05805	COG0438	transferase activity, transferring glycosyl groups
CO680_05810	COG0438	transferase activity, transferring glycosyl groups
CO680_05820	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CO680_05825	COG4856	YbbR-like protein
CO680_05835	COG0025	NhaP-type Na H and K H
CO680_05840	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CO680_05845	COG2176	DNA-directed DNA polymerase activity
CO680_05855	COG0802	atpase or kinase
CO680_05865	COG0280	phosphate acetyltransferase
CO680_05870	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CO680_05880	COG1126	abc transporter atp-binding protein
CO680_05885	COG0765	amino acid transport
CO680_05890	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CO680_05895	COG0557	exoribonuclease II activity
CO680_05915	COG0149	triose-phosphate isomerase activity
CO680_05925	COG3842	ATPase activity
CO680_05930	COG3833	ABC-type maltose transport systems, permease component
CO680_05935	COG1175	transmembrane transport
CO680_05955	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CO680_05965	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CO680_05970	COG0406	alpha-ribazole phosphatase activity
CO680_05975	COG0492	ferredoxin-NADP+ reductase activity
CO680_05980	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CO680_05985	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CO680_05990	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
CO680_05995	COG1950	PFAM Membrane protein of
CO680_06005	COG0589	response to stress
CO680_06015	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CO680_06020	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CO680_06025	COG1177	transmembrane transport
CO680_06030	COG1176	ABC-type spermidine putrescine transport system, permease component I
CO680_06035	COG3842	ATPase activity
CO680_06040	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CO680_06045	COG0049	tRNA binding
CO680_06050	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CO680_06055	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CO680_06060	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CO680_06065	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CO680_06075	COG1302	Protein conserved in bacteria
CO680_06080	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CO680_06090	COG2017	converts alpha-aldose to the beta-anomer
CO680_06095	COG4975	Glucose uptake
CO680_06100	COG3850	Histidine kinase
CO680_06100	COG5002	protein histidine kinase activity
CO680_06105	COG0745	RESPONSE REGULATOR receiver
CO680_06110	COG0402	S-adenosylhomocysteine deaminase activity
CO680_06125	COG0668	transmembrane transport
CO680_06140	COG3158	transport of potassium into the cell
CO680_06165	COG1968	undecaprenyl-diphosphatase activity
CO680_06185	COG1136	(ABC) transporter
CO680_06200	COG2217	Heavy metal translocating P-type atpase
CO680_06230	COG2183	response to ionizing radiation
CO680_06250	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
CO680_06285	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CO680_06290	COG1028	Short-chain dehydrogenase reductase Sdr
CO680_06310	COG2176	DNA-directed DNA polymerase activity
CO680_06315	COG0442	prolyl-tRNA aminoacylation
CO680_06320	COG0750	zinc metalloprotease
CO680_06325	COG4589	Belongs to the CDS family
CO680_06330	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CO680_06335	COG0561	phosphatase activity
CO680_06340	COG2246	polysaccharide biosynthetic process
CO680_06370	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CO680_06375	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
CO680_06380	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CO680_06395	COG1136	(ABC) transporter
CO680_06395	COG0577	efflux transmembrane transporter activity
CO680_06400	COG0561	phosphatase activity
CO680_06405	COG0308	aminopeptidase N
CO680_06415	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CO680_06420	COG0772	Belongs to the SEDS family
CO680_06430	COG1077	Cell shape determining protein MreB Mrl
CO680_06435	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CO680_06440	COG0561	phosphatase activity
CO680_06465	COG1744	ABC transporter substrate-binding protein PnrA-like
CO680_06470	COG0628	permease
CO680_06495	COG1064	alcohol dehydrogenase
CO680_06500	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CO680_06510	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CO680_06515	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
CO680_06530	COG0318	PFAM AMP-dependent synthetase and ligase
CO680_06535	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CO680_06545	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CO680_06585	COG2610	gluconate transmembrane transporter activity
CO680_06590	COG0693	protein deglycase activity
CO680_06595	COG1733	regulation of RNA biosynthetic process
CO680_06600	COG0588	phosphoglycerate mutase activity
CO680_06605	COG0492	ferredoxin-NADP+ reductase activity
CO680_06630	COG1744	ABC transporter substrate-binding protein PnrA-like
CO680_06635	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CO680_06640	COG2832	Protein of unknown function (DUF454)
CO680_06645	COG2814	Major facilitator Superfamily
CO680_06650	COG0305	Participates in initiation and elongation during chromosome replication
CO680_06655	COG0359	binds to the 23S rRNA
CO680_06665	COG4608	Belongs to the ABC transporter superfamily
CO680_06670	COG0444	Belongs to the ABC transporter superfamily
CO680_06675	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CO680_06680	COG0601	transmembrane transport
CO680_06685	COG4166	transmembrane transport
CO680_06690	COG0765	amino acid transport
CO680_06695	COG0765	amino acid transport
CO680_06700	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CO680_06705	COG1126	abc transporter atp-binding protein
CO680_06720	COG0194	GDP metabolic process
CO680_06730	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CO680_06735	COG0673	inositol 2-dehydrogenase activity
CO680_06745	COG0180	Tryptophanyl-tRNA synthetase
CO680_06750	COG3973	AAA domain
CO680_06755	COG2337	Toxic component of a toxin-antitoxin (TA) module
CO680_06770	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CO680_06775	COG0504	CTP synthase activity
CO680_06780	COG3343	RNA polymerase activity
CO680_06790	COG1078	dGTPase activity
CO680_06800	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CO680_06805	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CO680_06820	COG5002	protein histidine kinase activity
CO680_06825	COG0745	RESPONSE REGULATOR receiver
CO680_06835	COG0516	GMP reductase activity
CO680_06835	COG0517	IMP dehydrogenase activity
CO680_06855	COG0151	Belongs to the GarS family
CO680_06860	COG0138	bifunctional purine biosynthesis protein purh
CO680_06865	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CO680_06870	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CO680_06880	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CO680_06885	COG0047	phosphoribosylformylglycinamidine synthase activity
CO680_06890	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CO680_06895	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CO680_06905	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CO680_06915	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CO680_06920	COG0629	single-stranded DNA binding
CO680_06925	COG0360	Binds together with S18 to 16S ribosomal RNA
CO680_06935	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CO680_06945	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CO680_06950	COG1051	belongs to the nudix hydrolase family
CO680_06960	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CO680_06965	COG2814	Major facilitator Superfamily
CO680_06970	COG1074	ATP-dependent DNA helicase activity
CO680_06975	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
CO680_06980	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CO680_06985	COG0531	amino acid
CO680_06990	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
CO680_07015	COG2244	polysaccharide biosynthetic process
CO680_07025	COG0438	transferase activity, transferring glycosyl groups
CO680_07030	COG0495	leucyl-tRNA aminoacylation
CO680_07035	COG0671	phosphoesterase, PA-phosphatase related
CO680_07060	COG1609	Transcriptional regulator
CO680_07065	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CO680_07075	COG2807	transmembrane transport
CO680_07080	COG0431	NADPH-dependent FMN reductase
CO680_07085	COG1063	alcohol dehydrogenase
CO680_07090	COG0386	Belongs to the glutathione peroxidase family
CO680_07095	COG1132	(ABC) transporter
CO680_07100	COG1132	(ABC) transporter
CO680_07105	COG2514	catechol 2,3-dioxygenase activity
CO680_07135	COG0028	Belongs to the TPP enzyme family
CO680_07160	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CO680_07175	COG3842	ATPase activity
CO680_07180	COG3250	beta-galactosidase activity
CO680_07195	COG1175	transmembrane transport
CO680_07225	COG1247	-acetyltransferase
CO680_07235	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CO680_07240	COG0149	triose-phosphate isomerase activity
CO680_07250	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CO680_07255	COG0693	protein deglycase activity
CO680_07260	COG3764	Sortase (surface protein transpeptidase)
CO680_07270	COG2801	Transposase and inactivated derivatives
CO680_07300	COG1215	transferase activity, transferring glycosyl groups
CO680_07320	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CO680_07325	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CO680_07330	COG0489	protein tyrosine kinase activity
CO680_07340	COG4464	protein tyrosine phosphatase activity
CO680_07345	COG4989	oxidoreductase activity
CO680_07350	COG1088	dTDP-glucose 4,6-dehydratase activity
CO680_07360	COG0626	cystathionine gamma-synthase activity
CO680_07365	COG1914	H( )-stimulated, divalent metal cation uptake system
CO680_07415	COG0438	transferase activity, transferring glycosyl groups
CO680_07420	COG2084	Dehydrogenase
CO680_07425	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CO680_07430	COG2233	PERMEase
CO680_07435	COG2814	Major facilitator Superfamily
CO680_07445	COG1956	GAF domain-containing protein
CO680_07450	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CO680_07465	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CO680_07470	COG4608	Belongs to the ABC transporter superfamily
CO680_07475	COG0444	Belongs to the ABC transporter superfamily
CO680_07485	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CO680_07490	COG0601	transmembrane transport
CO680_07500	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CO680_07510	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
CO680_07515	COG1737	Transcriptional regulator
CO680_07525	COG2801	Transposase and inactivated derivatives
CO680_07535	COG2261	transglycosylase associated protein
CO680_07565	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CO680_07610	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CO680_07615	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
CO680_07630	COG0037	tRNA processing
CO680_07640	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
CO680_07645	COG2244	polysaccharide biosynthetic process
CO680_07650	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CO680_07655	COG0193	aminoacyl-tRNA hydrolase activity
CO680_07670	COG1511	domain protein
CO680_07695	COG2217	Heavy metal translocating P-type atpase
CO680_07700	COG0390	transport system, permease component
CO680_07705	COG4619	ABC transporter
CO680_07715	COG2323	membrane
CO680_07730	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CO680_07735	COG1609	Transcriptional regulator
CO680_07740	COG0561	phosphatase activity
CO680_07745	COG1247	-acetyltransferase
CO680_07755	COG0702	epimerase
CO680_07765	COG0028	Belongs to the TPP enzyme family
CO680_07775	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CO680_07780	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CO680_07785	COG0656	L-ascorbic acid biosynthetic process
CO680_07830	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CO680_07835	COG0601	transmembrane transport
CO680_07840	COG4608	Belongs to the ABC transporter superfamily
CO680_07850	COG0697	spore germination
CO680_07860	COG3760	aminoacyl-tRNA metabolism involved in translational fidelity
CO680_07875	COG1134	teichoic acid transport
CO680_07875	COG1388	LysM domain
CO680_07885	COG2818	Glycosylase
CO680_07905	COG1983	PspC domain protein
CO680_07910	COG1811	Na channel or pump
CO680_07940	COG0737	Belongs to the 5'-nucleotidase family
CO680_07955	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
CO680_07965	COG1316	TRANSCRIPTIONal
CO680_07970	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
CO680_07975	COG2131	deaminase
CO680_07985	COG1253	flavin adenine dinucleotide binding
CO680_07990	COG1253	flavin adenine dinucleotide binding
CO680_07995	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CO680_08000	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
CO680_08005	COG0084	hydrolase, TatD family'
CO680_08015	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CO680_08015	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CO680_08050	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CO680_08070	COG1368	sulfuric ester hydrolase activity
CO680_08075	COG2153	protein acetylation
CO680_08090	COG2409	Drug exporters of the RND superfamily
CO680_08100	COG1464	Belongs to the NlpA lipoprotein family
CO680_08105	COG2011	ABC-type metal ion transport system permease component
CO680_08110	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CO680_08120	COG4690	dipeptidase activity
CO680_08130	COG0187	DNA topoisomerase II activity
CO680_08135	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CO680_08140	COG2501	S4 domain
CO680_08145	COG0592	DNA-directed DNA polymerase activity
CO680_08150	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CO680_08155	COG0230	Belongs to the bacterial ribosomal protein bL34 family
CO680_08160	COG0594	ribonuclease P activity
CO680_08165	COG0706	membrane insertase activity
CO680_08180	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CO680_08185	COG0765	amino acid transport
CO680_08190	COG1309	transcriptional regulator
CO680_08225	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CO680_08230	COG1120	ATPase activity
CO680_08250	COG5386	Cell surface protein
CO680_08255	COG0569	domain protein
CO680_08260	COG1113	amino acid transport
CO680_08270	COG2801	Transposase and inactivated derivatives
CO680_08295	COG2022	thiamine diphosphate biosynthetic process
CO680_08300	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CO680_08305	COG1301	dicarboxylic acid transport
CO680_08310	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CO680_08315	COG1126	abc transporter atp-binding protein
CO680_08320	COG0765	amino acid transport
CO680_08325	COG0626	cystathionine gamma-synthase activity
CO680_08330	COG0626	cystathionine gamma-synthase activity
CO680_08335	COG0460	homoserine dehydrogenase
CO680_08340	COG0583	DNA-binding transcription factor activity
CO680_08345	COG0384	phenazine biosynthesis protein PhzF
CO680_08365	COG0028	Belongs to the TPP enzyme family
CO680_08370	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
CO680_08400	COG2116	formate transmembrane transporter activity
CO680_08405	COG1304	FMN binding
CO680_08410	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CO680_08415	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CO680_08420	COG0561	phosphatase activity
CO680_08425	COG0328	RNA-DNA hybrid ribonuclease activity
CO680_08435	COG1131	(ABC) transporter
CO680_08450	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
CO680_08460	COG2252	PERMEase
CO680_08505	COG0149	triose-phosphate isomerase activity
CO680_08505	COG0126	phosphoglycerate kinase activity
CO680_08515	COG0531	amino acid
CO680_08520	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CO680_08525	COG0110	maltose O-acetyltransferase activity
CO680_08530	COG0110	maltose O-acetyltransferase activity
CO680_08535	COG0436	Aminotransferase
CO680_08545	COG1881	PFAM PEBP family protein
CO680_08555	COG2962	Rard protein
CO680_08560	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CO680_08570	COG1609	Transcriptional regulator
CO680_08590	COG0656	L-ascorbic acid biosynthetic process
CO680_08595	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CO680_08605	COG2153	protein acetylation
CO680_08630	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
CO680_08630	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
CO680_08635	COG1268	BioY protein
CO680_08640	COG0402	S-adenosylhomocysteine deaminase activity
CO680_08645	COG2233	PERMEase
CO680_08665	COG1136	(ABC) transporter
CO680_08670	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CO680_08685	COG1827	regulation of RNA biosynthetic process
CO680_08690	COG0477	Major facilitator Superfamily
CO680_08695	COG0789	Transcriptional regulator
CO680_08700	COG1028	Short-chain dehydrogenase reductase Sdr
CO680_08710	COG0745	RESPONSE REGULATOR receiver
CO680_08715	COG5002	protein histidine kinase activity
CO680_08720	COG0586	Pfam SNARE associated Golgi protein
CO680_08730	COG0463	Glycosyl transferase, family 2
CO680_08740	COG0640	Transcriptional regulator
CO680_08745	COG3940	Belongs to the glycosyl hydrolase 43 family
CO680_08755	COG3048	D-serine ammonia-lyase activity
CO680_08800	COG2357	RelA SpoT domain protein
CO680_08805	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CO680_08810	COG4720	Psort location CytoplasmicMembrane, score
CO680_08815	COG1122	ATPase activity
CO680_08825	COG0277	FAD linked oxidase domain protein
CO680_08830	COG0436	Aminotransferase
CO680_08855	COG1028	Short-chain dehydrogenase reductase Sdr
CO680_08865	COG0656	L-ascorbic acid biosynthetic process
CO680_08875	COG1126	abc transporter atp-binding protein
CO680_08880	COG0765	amino acid transport
CO680_08885	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CO680_08890	COG1254	Belongs to the acylphosphatase family
CO680_08900	COG0628	permease
CO680_08915	COG1113	amino acid transport
CO680_08945	COG1012	belongs to the aldehyde dehydrogenase family
CO680_08950	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CO680_08955	COG2855	membrane
CO680_08965	COG0583	DNA-binding transcription factor activity
CO680_08980	COG0531	amino acid
CO680_08990	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CO680_08995	COG0477	Major facilitator Superfamily
CO680_09005	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CO680_09015	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CO680_09025	COG1131	(ABC) transporter
CO680_09030	COG1309	transcriptional regulator
CO680_09035	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
CO680_09050	COG0531	amino acid
CO680_09070	COG1328	CTP reductase activity
CO680_09075	COG0602	queuosine metabolic process
CO680_09080	COG0396	ATPase activity
CO680_09085	COG0719	Fe-S assembly protein
CO680_09090	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CO680_09095	COG0822	iron-sulfur transferase activity
CO680_09100	COG0719	Fe-S assembly protein
CO680_09105	COG1113	amino acid transport
CO680_09110	COG0531	amino acid
CO680_09115	COG0252	asparaginase activity
CO680_09120	COG4443	Transcriptional Coactivator p15 (PC4)
CO680_09135	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
CO680_09140	COG0318	PFAM AMP-dependent synthetase and ligase
CO680_09145	COG2801	Transposase and inactivated derivatives
CO680_09160	COG1011	Hydrolase
CO680_09165	COG0531	amino acid
CO680_09170	COG0745	RESPONSE REGULATOR receiver
CO680_09175	COG5002	protein histidine kinase activity
CO680_09185	COG1194	a g-specific adenine glycosylase
CO680_09190	COG0357	Ribosomal RNA small subunit methyltransferase G
CO680_09195	COG1192	Involved in chromosome partitioning
CO680_09200	COG1475	DNA binding
CO680_09210	COG0012	GTP binding
CO680_09220	COG0745	RESPONSE REGULATOR receiver
CO680_09280	COG3091	SprT-like family
CO680_09285	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
CO680_09285	COG2755	lipolytic protein G-D-S-L family
CO680_09300	COG1121	(ABC) transporter
CO680_09310	COG0488	(ABC) transporter
CO680_09320	COG0534	Mate efflux family protein
CO680_09340	COG2160	L-arabinose isomerase activity
CO680_09345	COG0656	L-ascorbic acid biosynthetic process
CO680_09360	COG1126	abc transporter atp-binding protein
CO680_09365	COG0765	amino acid transport
CO680_09375	COG0765	amino acid transport
CO680_09390	COG1418	mRNA catabolic process
CO680_09395	COG2814	Major facilitator Superfamily
CO680_09400	COG2188	Transcriptional regulator
CO680_09405	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
CO680_09415	COG3590	peptidase
CO680_09435	COG2217	Heavy metal translocating P-type atpase
CO680_09440	COG1454	alcohol dehydrogenase
CO680_09440	COG1012	belongs to the aldehyde dehydrogenase family
CO680_09445	COG0708	Exodeoxyribonuclease III
CO680_09460	COG0588	phosphoglycerate mutase activity
CO680_09465	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CO680_09470	COG1132	(ABC) transporter
CO680_09475	COG1132	(ABC) transporter
CO680_09500	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CO680_09505	COG3442	glutamine amidotransferase
CO680_09510	COG1435	thymidine kinase activity
CO680_09520	COG2890	protein-(glutamine-N5) methyltransferase activity
CO680_09525	COG0009	L-threonylcarbamoyladenylate synthase
CO680_09530	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CO680_09545	COG2233	PERMEase
CO680_09550	COG0356	it plays a direct role in the translocation of protons across the membrane
CO680_09555	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CO680_09560	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CO680_09565	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CO680_09570	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CO680_09575	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CO680_09580	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CO680_09585	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CO680_09590	COG1428	Deoxynucleoside kinase
CO680_09595	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CO680_09620	COG4463	regulation of RNA biosynthetic process
CO680_09625	COG0542	response to heat